Görüntü Eşleme ve Genetik Algoritmalar Kullanarak Görüntü içinde Görüntü Arama

Directory of Open Access Journals (Sweden)

Mehmet Karakoc

2015-10-01

Full Text Available Bu çalışmada esas alınan problem, görüntü içinde görüntü aramayı etkin bir şekilde gerçekleştirebilmektir. Bu amaçla görüntü işleme kapsamında yer alan görüntü eşleme teknikleri ile arama algoritmaları birlikte kullanılmıştır. Görüntü eşleme için Yapay Sinir Ağları ile görüntünün ortalama renk değeri, görüntüdeki renk değerlerinin standart sapması, korelasyon ve görüntü kenar parametreleri gibi özellikler; görüntü arama için Genetik Algoritmalar kullanılmıştır. Bu çalışmada, akıllı arama algoritmaları, hızlı görüntü eşleme yöntemleri ve paralel programlama tekniklerine dayanan bütünleşik bir yöntem önerilmiş ve kullanılmıştır. Önerilen yöntem çok sayıda düşük ve yüksek çözünürlüklü referans ve şablon görüntü üzerinde test edilmiştir. Elde edilen sonuçlar önerilen yöntemin eşleşen görüntüleri elde etmede başarılı olduğunu ve toplam arama süresini azalttığını göstermiştir.

Influence of Met-Ocean Condition Forecasting Uncertainties on Weather Window Predictions for Offshore Operations

DEFF Research Database (Denmark)

Gintautas, Tomas; Sørensen, John Dalsgaard

2017-01-01

The article briefly presents a novel methodology of weather window estimation for offshore operations and mainly focuses on effects of met-ocean condition forecasting uncertainties on weather window predictions when using the proposed methodology. It is demonstrated that the proposed methodology...... to include stochastic variables, representing met-ocean forecasting uncertainties and the results of such modification are given in terms of predicted weather windows for a selected test case....

SUPPORT OF NEW COMPUTER HARDWARE AT LUCH'S MC and A SYSTEM: PROBLEMS AND A SOLUTION

International Nuclear Information System (INIS)

Fedoseev, Victor; Shanin, Oleg

2009-01-01

Microsoft Windows NT 4.0 operating system is the only software product certified in Russia for using in MC and A systems. In the paper a solution for allowing the installation of this outdated operating system on new computers is discussed. The solution has been successfully tested and has been in use at Luch's network since March 2008. Furthermore, it is being recommended for other Russian enterprises for the same purpose. Introduction Typically, the software part of a nuclear material control and accounting (MC and A) system consists of an operating system (OS), database management systems (DBMS), accounting program itself and database of nuclear materials. Russian regulations require the operating system and database for MC and A be certified for information security, and the whole system must pass an accreditation. Historically, the only certified operating system for MC and A still continues to be Microsoft Windows NT 4.0 Server/Workstation. Attempts to certify newer versions of Windows failed. Luch, like most other Russian sites, uses Microsoft Windows NT 4.0 and SQL Server 6.5. Luch's specialists have developed an application (LuchMAS) for accounting purposes. Starting from about 2004, some problems appeared in Luch's accounting system. They were related to the complexity of installing Windows NT 4.0 on new computers. At first, it was possible to solve the problem choosing computer equipment that is compatible with Windows NT 4.0 or selecting certain operating system settings. Over time, the problem worsened and now it is almost impossible to install Windows NT 4.0 on new computers. The reason is the lack of hardware drivers in the outdated operating system. The problem was serious enough that it could have affected the long-term sustainability of Luch's MC and A system if adequate alternate measures were not developed.

Clostridium botulinum strains producing BoNT/F4 or BoNT/F5.

Science.gov (United States)

Raphael, Brian H; Bradshaw, Marite; Kalb, Suzanne R; Joseph, Lavin A; Lúquez, Carolina; Barr, John R; Johnson, Eric A; Maslanka, Susan E

2014-05-01

Botulinum neurotoxin type F (BoNT/F) may be produced by Clostridium botulinum alone or in combination with another toxin type such as BoNT/A or BoNT/B. Type F neurotoxin gene sequences have been further classified into seven toxin subtypes. Recently, the genome sequence of one strain of C. botulinum (Af84) was shown to contain three neurotoxin genes (bont/F4, bont/F5, and bont/A2). In this study, eight strains containing bont/F4 and seven strains containing bont/F5 were examined. Culture supernatants produced by these strains were incubated with BoNT/F-specific peptide substrates. Cleavage products of these peptides were subjected to mass spectral analysis, allowing detection of the BoNT/F subtypes present in the culture supernatants. PCR analysis demonstrated that a plasmid-specific marker (PL-6) was observed only among strains containing bont/F5. Among these strains, Southern hybridization revealed the presence of an approximately 242-kb plasmid harboring bont/F5. Genome sequencing of four of these strains revealed that the genomic backgrounds of strains harboring either bont/F4 or bont/F5 are diverse. None of the strains analyzed in this study were shown to produce BoNT/F4 and BoNT/F5 simultaneously, suggesting that strain Af84 is unusual. Finally, these data support a role for the mobility of a bont/F5-carrying plasmid among strains of diverse genomic backgrounds.

Windows user-friendly code package development for operation of research reactors

International Nuclear Information System (INIS)

Hoang Anh Tuan

1998-01-01

The content of the project was to developed: 1. MS Windows interface to spectral codes like THERMOS, PEACO-COLLIS, GRACE and burn-up code. 2. MS Windows C-language burn-up diffusion hexagonal lattice code. The overall scope of the project was to develop a PC-based MS Windows code package for operation of Dalat research reactor. Various problems relating to neutronic physics like thermalization, resonance treatment, fast spectral treatment, change of isotopic concentration during burn-up time as well as burn-up distribution in the reactor core are considered in parallel to application of informatics technique. The developing process is a subject of the concept of user-friendly interface between end-users and the code package. High level input features through system of icon, menu, dialog box with regard to Common User Access (CUA) convention and sophisticated graphical output in MS Windows environment was used. The user-computer interface is also enhanced by using both keyboard and mouse, which creates a very natural manner for end-user. (author)

Development of new S-band RF window for stable high-power operation in linear accelerator RF system

Science.gov (United States)

Joo, Youngdo; Lee, Byung-Joon; Kim, Seung-Hwan; Kong, Hyung-Sup; Hwang, Woonha; Roh, Sungjoo; Ryu, Jiwan

2017-09-01

For stable high-power operation, a new RF window is developed in the S-band linear accelerator (Linac) RF systems of the Pohang Light Source-II (PLS-II) and the Pohang Accelerator Laboratory X-ray Free-Electron Laser (PAL-XFEL). The new RF window is designed to mitigate the strength of the electric field at the ceramic disk and also at the waveguide-cavity coupling structure of the conventional RF window. By replacing the pill-box type cavity in the conventional RF window with an overmoded cavity, the electric field component perpendicular to the ceramic disk that caused most of the multipacting breakdowns in the ceramic disk was reduced by an order of magnitude. The reduced electric field at the ceramic disk eliminated the Ti-N coating process on the ceramic surface in the fabrication procedure of the new RF window, preventing the incomplete coating from spoiling the RF transmission and lowering the fabrication cost. The overmoded cavity was coupled with input and output waveguides through dual side-wall coupling irises to reduce the electric field strength at the waveguide-cavity coupling structure and the possibility of mode competitions in the overmoded cavity. A prototype of the new RF window was fabricated and fully tested with the Klystron peak input power, pulse duration and pulse repetition rate of 75 MW, 4.5 μs and 10 Hz, respectively, at the high-power test stand. The first mass-produced new RF window installed in the PLS-II Linac is running in normal operation mode. No fault is reported to date. Plans are being made to install the new RF window to all S-band accelerator RF modules of the PLS-II and PAL-XFEL Linacs. This new RF window may be applied to the output windows of S-band power sources like Klystron as wells as the waveguide windows of accelerator facilities which operate in S-band.

Mastering Windows 7 Deployment

CERN Document Server

Finn, Aidan; van Surksum, Kenneth

2011-01-01

Get professional-level instruction on Windows 7 deployment tools Enterprise-level operating system deployment is challenging and requires knowledge of specific tools. It is expected that Windows 7 will be extensively deployed in businesses worldwide. This comprehensive Sybex guide provides thorough coverage of the Microsoft deployment tools that were specifically created for Windows 7, preparing system administrators, MIS professionals, and corporate programmers to tackle the task effectively.Companies worldwide are expected to deploy Windows 7 as their enterprise operating system; system admi

Improved Methodology of Weather Window Prediction for Offshore Operations Based on Probabilities of Operation Failure

DEFF Research Database (Denmark)

Gintautas, Tomas; Sørensen, John Dalsgaard

2017-01-01

The offshore wind industry is building and planning new wind farms further offshore due to increasing demand on sustainable energy production and already occupied prime resource locations closer to shore. Costs of operation and maintenance, transport and installation of offshore wind turbines...... already contribute significantly to the cost of produced electricity and will continue to increase, due to moving further offshore, if the current techniques of predicting offshore wind farm accessibility are to stay the same. The majority of offshore operations are carried out by specialized ships...... that must be hired for the duration of the operation. Therefore, offshore wind farm accessibility and costs of offshore activities are primarily driven by the expected number of operational hours offshore and waiting times for weather windows, suitable for offshore operations. Having more reliable weather...

HYDRAULICS AND MIXING EVALUATIONS FOR NT-21/41 TANKS

Energy Technology Data Exchange (ETDEWEB)

Lee, S.; Barnes, O.

2014-11-17

The hydraulic results demonstrate that pump head pressure of 20 psi recirculates about 5.6 liters/min flowrate through the existing 0.131-inch orifice when a valve connected to NT-41 is closed. In case of the valve open to NT-41, the solution flowrates to HB-Line tanks, NT-21 and NT-41, are found to be about 0.5 lpm and 5.2 lpm, respectively. The modeling calculations for the mixing operations of miscible fluids contained in the HB-Line tank NT-21 were performed by taking a three-dimensional Computational Fluid Dynamics (CFD) approach. The CFD modeling results were benchmarked against the literature results and the previous SRNL test results to validate the model. Final performance calculations were performed for the nominal case by using the validated model to quantify the mixing time for the HB-Line tank. The results demonstrate that when a pump recirculates a solution volume of 5.7 liters every minute out of the 72-liter tank contents containing two acid solutions of 2.7 M and 0 M concentrations (i.e., water), a minimum mixing time of 1.5 hours is adequate for the tank contents to get the tank contents adequately mixed. In addition, the sensitivity results for the tank contents of 8 M existing solution and 1.5 M incoming species show that the mixing time takes about 2 hours to get the solutions mixed.

Tokamak physics experiment: Diagnostic windows study

International Nuclear Information System (INIS)

Merrigan, M.; Wurden, G.A.

1995-11-01

We detail the study of diagnostic windows and window thermal stress remediation in the long-pulse, high-power Tokamak Physics Experiment (TPX) operation. The operating environment of the TPX diagnostic windows is reviewed, thermal loads on the windows estimated, and cooling requirements for the windows considered. Applicable window-cooling technology from other fields is reviewed and its application to the TPX windows considered. Methods for TPX window thermal conditioning are recommended, with some discussion of potential implementation problems provided. Recommendations for further research and development work to ensure performance of windows in the TPX system are presented

76 FR 11415 - Federal Motor Vehicle Safety Standards; Power-Operated Window, Partition, and Roof Panel Systems

Science.gov (United States)

2011-03-02

... [Docket No. NHTSA-2011-0027] RIN 2127-AK52 Federal Motor Vehicle Safety Standards; Power-Operated Window, Partition, and Roof Panel Systems AGENCY: National Highway Traffic Safety Administration (NHTSA), Department... automatic reversal systems (ARS) for power windows and to make a final decision. The agency has decided not...

Windows 7 is supported at CERN

CERN Multimedia

IT Department

2010-01-01

The new version of the Windows operating system - Windows 7 - is now officially supported at CERN. Windows 7 32-bit is now the default operating system for the new computers at CERN. What’s new in Windows 7 Users of Windows XP will find many new features and options. Users of Windows Vista will feel very familiar with one major difference: higher performance and better responsiveness of the operating system. Other enhancements include: refined Aero desktop that makes it easier to navigate between your different application windows; new snapping windows that allows user to resize a window simply by dragging it to the edge of the screen and “pin” that allows grouping and arranging often accessed applications on the taskbar. Windows 7 introduces the new concept of libraries – containers for user files that have links to different local or network folders. By default, users can see four libraries: Documents, Music, Pictures and Videos. These libraries point to the cor...

Windows® Internals

CERN Document Server

Russinovich, Mark E; Ionescu, Alex

2009-01-01

See how the core components of the Windows operating system work behind the scenes-guided by a team of internationally renowned internals experts. Fully updated for Windows Server 2008 and Windows Vista, this classic guide delivers key architectural insights on system design, debugging, performance, and support-along with hands-on experiments to experience Windows internal behavior firsthand.Delve inside Windows architecture and internals:Understand how the core system and management mechanisms work-from the object manager to services to the registryExplore internal system data structures usin

MS Windows domēna darbstacijas migrācijas iespējas no MS Windows XP uz MS Windows 7.

OpenAIRE

Zariņš, Valdis

2009-01-01

Kvalifikācijas darbā tiek aprakstītas MS Windows domēna darbstacijas migrācijas iespējas no MS Windows XP uz MS Windows 7, kā servera operētājsistēmas izmantojot tādus Microsoft produktus, kā Microsoft Windows Server 2003 un Microsoft Windows Server 2008. Kvalifikācijas darba teorētiskaja daļā tiek apskatīti Microsoft Windows 7 priekšrocības un uzlabojumus gan no darbstacijas lietotāja , gan no darbstacijas administratora puses. Ir aprakstītas Microsoft Windows Server 2008 jauninājumu ie...

Visualizing feasible operating ranges within tissue engineering systems using a "windows of operation" approach: a perfusion-scaffold bioreactor case study.

Science.gov (United States)

McCoy, Ryan J; O'Brien, Fergal J

2012-12-01

Tissue engineering approaches to developing functional substitutes are often highly complex, multivariate systems where many aspects of the biomaterials, bio-regulatory factors or cell sources may be controlled in an effort to enhance tissue formation. Furthermore, success is based on multiple performance criteria reflecting both the quantity and quality of the tissue produced. Managing the trade-offs between different performance criteria is a challenge. A "windows of operation" tool that graphically represents feasible operating spaces to achieve user-defined levels of performance has previously been described by researchers in the bio-processing industry. This paper demonstrates the value of "windows of operation" to the tissue engineering field using a perfusion-scaffold bioreactor system as a case study. In our laboratory, perfusion bioreactor systems are utilized in the context of bone tissue engineering to enhance the osteogenic differentiation of cell-seeded scaffolds. A key challenge of such perfusion bioreactor systems is to maximize the induction of osteogenesis but minimize cell detachment from the scaffold. Two key operating variables that influence these performance criteria are the mean scaffold pore size and flow-rate. Using cyclooxygenase-2 and osteopontin gene expression levels as surrogate indicators of osteogenesis, we employed the "windows of operation" methodology to rapidly identify feasible operating ranges for the mean scaffold pore size and flow-rate that achieved user-defined levels of performance for cell detachment and differentiation. Incorporation of such tools into the tissue engineer's armory will hopefully yield a greater understanding of the highly complex systems used and help aid decision making in future translation of products from the bench top to the market place. Copyright © 2012 Wiley Periodicals, Inc.

Operational Windows for Dry-Wall and Wetted-Wall IFE Chambers

International Nuclear Information System (INIS)

Najmabadi, F.; Raffray, A.R.; Bromberg, L.

2004-01-01

The ARIES-IFE study was an integrated study of inertial fusion energy (IFE) chambers and chamber interfaces with the driver and target systems. Detailed analysis of various subsystems was performed parametrically to uncover key physics/technology uncertainties and to identify constraints imposed by each subsystem. In this paper, these constraints (e.g., target injection and tracking, thermal response of the first wall, and driver propagation and focusing) were combined to understand the trade-offs, to develop operational windows for chamber concepts, and to identify high-leverage research and development directions for IFE research. Some conclusions drawn in this paper are (a) the detailed characterization of the target yield and spectrum has a major impact on the chamber; (b) it is prudent to use a thin armor instead of a monolithic first wall for dry-wall concepts; (c) for dry-wall concepts with direct-drive targets, the most stringent constraint is imposed by target survival during the injection process; (d) for relatively low yield targets (<250 MJ), an operational window with no buffer gas may exist; (e) for dry-wall concepts with indirect-drive targets, a high buffer gas pressure would be necessary that may preclude propagation of the laser driver and require assisted pinch transport for the heavy-ion driver; and (f) generation and transport of aerosols in the chamber is the key feasibility issue for wetted-wall concepts

Windows 8.1 bible

CERN Document Server

Boyce, Jim; Tidrow, Rob

2014-01-01

Windows 8.1 coverage that goes above and beyond all competitors? Serving as an evolutionary update to Windows 8, Windows 8.1 provides critical changes to parts of Windows 8, such as greater customization of the interface and boot operations, return of a 'start button' that reveals apps, greater integration between the two interfaces, and updates to apps. Weighing in at nearly 1000 pages, Windows 8.1 Bible provides deeper Windows insight than any other book on the market. It's valuable for both professionals needing a guide to the nooks and crannies of Windows and regular users wanting a wide

Controlled time of arrival windows for already initiated energy-neutral continuous descent operations

OpenAIRE

Dalmau Codina, Ramon; Prats Menéndez, Xavier

2017-01-01

Continuous descent operations with controlled times of arrival at one or several metering fixes could enable environmentally friendly procedures without compromising terminal airspace capacity. This paper focuses on controlled time of arrival updates once the descent has been already initiated, assessing the feasible time window (and associated fuel consumption) of continuous descent operations requiring neither thrust nor speed-brake usage along the whole descent (i.e. only elevator control ...

NT2 derived neuronal and astrocytic network signalling.

Directory of Open Access Journals (Sweden)

Eric J Hill

Full Text Available A major focus of stem cell research is the generation of neurons that may then be implanted to treat neurodegenerative diseases. However, a picture is emerging where astrocytes are partners to neurons in sustaining and modulating brain function. We therefore investigated the functional properties of NT2 derived astrocytes and neurons using electrophysiological and calcium imaging approaches. NT2 neurons (NT2Ns expressed sodium dependent action potentials, as well as responses to depolarisation and the neurotransmitter glutamate. NT2Ns exhibited spontaneous and coordinated calcium elevations in clusters and in extended processes, indicating local and long distance signalling. Tetrodotoxin sensitive network activity could also be evoked by electrical stimulation. Similarly, NT2 astrocytes (NT2As exhibited morphology and functional properties consistent with this glial cell type. NT2As responded to neuronal activity and to exogenously applied neurotransmitters with calcium elevations, and in contrast to neurons, also exhibited spontaneous rhythmic calcium oscillations. NT2As also generated propagating calcium waves that were gap junction and purinergic signalling dependent. Our results show that NT2 derived astrocytes exhibit appropriate functionality and that NT2N networks interact with NT2A networks in co-culture. These findings underline the utility of such cultures to investigate human brain cell type signalling under controlled conditions. Furthermore, since stem cell derived neuron function and survival is of great importance therapeutically, our findings suggest that the presence of complementary astrocytes may be valuable in supporting stem cell derived neuronal networks. Indeed, this also supports the intriguing possibility of selective therapeutic replacement of astrocytes in diseases where these cells are either lost or lose functionality.

Grab Windows training opportunities; check CERN Windows roadmap!

CERN Multimedia

IT Department

2011-01-01

CERN Operating Systems and Information Services group (IT-OIS) actively monitors market trends to check how new software products correspond to CERN needs. In the Windows world, Windows 7 has been a big hit, with over 1500 Windows 7 PCs within less than a year since its support was introduced at CERN. No wonder: Windows XP is nearly 10 years old and is steadily approaching the end of its life-cycle. At CERN, support for Windows XP will stop at the end of December 2012. Compared to Vista, Windows 7 has the same basic hardware requirements, but offers higher performance, so the decision to upgrade is rather straightforward. CERN support for Vista will end in June 2011. In the world of Microsoft Office, version 2007 offers better integration with the central services than the older version 2003. Progressive upgrade from 2003 to 2007 is planned to finish in September 2011, but users are encouraged to pro-actively upgrade at their convenience. Please note that Office 2007 brings an important change in the area of ...

Development of actively cooled windows for plasma observation during quasi-continuous operation of the W7-X stellarator

International Nuclear Information System (INIS)

Konig, R.; Grosser, K.; Hildebrandt, D.; Pasch, E.; Werner, T.; Klinger, T.; Ogorodnikova, O.

2005-01-01

With the stellarator W7-X a step to quasi-continuous plasma operation will be made. The cooling system of the machine is designed such that two 30 min discharges can be run per day. Right from the start of operation 10 MW of ECRH heating power will be available for quasi-continuous operation. A working group 'Plasma Facing Optical Components' has been formed which presently concentrates on the development of water cooled windows for UV/VR/IR periscopes which can withstand the expected maximum heat loads of up to 50 kW/m 2 which due to the predominantly short wavelength nature of the radiation emitted by the plasma will be absorbed within the first millimeter of any window. We will report on the detailed Finite Element (ANSYS R ) calculations of the heat and stress distribution across the windows. Calculations have been undertaken for a large number of different window materials which are required for the various spectral regions covered by the miscellaneous diagnostics, so that the most suitable material for each application can easily be identified. Also the dependence of the cooling rate on the window diameter and thickness has been studied. The calculations show that at a power load of 50 kW/m 2 cooled sapphire windows can be used for window sizes up to ∼200 mm diameter but that for many of the other materials like ZnSe, ZnS, CaF 2 , MgF 2 and quartz window sizes need to be limited to considerably smaller sizes. Detailed simulations of the local radiation power load distribution demonstrate that by careful design the load on individual optical components can be considerably reduced. A vacuum test chamber, equipped with a vacuum compatible IR heater has been build. In this chamber a low cost, easily exchangeable window design using Helicoflex gaskets on either side of a 60 mm exposed diameter quartz window have been successfully tested over 70 heat cycles up to a maximum temperature of 450 o C at power loads of 15 kW/m 2 . The design proved to be water and

Botulinum toxin (BoNT) and back pain.

Science.gov (United States)

Porta, Mauro; Maggioni, G

2004-02-01

Myofascial pain syndrome is defined as subacute or chronic pain with sensory, motor and autonomic symptoms referred from active trigger points with associated painful dysfunctions. Authors present the usefulness of botulinum toxin A or B (BoNT/A or BoNT/B) injected into target muscles since the toxin is capable of controlling not only the muscular spasm but mostly the pain by alternative mechanisms of action, which are discussed. Posology of BoNT, technical aspects and results are presented. BoNT represents an interesting and useful tool for an adequate management of patients with myofascial pain.

Mastering Microsoft Windows Server 2008 R2

CERN Document Server

Minasi, Mark; Finn, Aidan

2010-01-01

The one book you absolutely need to get up and running with Windows Server 2008 R2. One of the world's leading Windows authorities and top-selling author Mark Minasi explores every nook and cranny of the latest version of Microsoft's flagship network operating system, Windows Server 2008 R2, giving you the most in-depth coverage in any book on the market.: Focuses on Windows Windows Server 2008 R2, the newest version of Microsoft's Windows' server line of operating system, and the ideal server for new Windows 7 clients; Author Mark Minasi is one of the world's leading Windows authorities and h

Windows 8 secrets

CERN Document Server

Thurrott, Paul

2012-01-01

Tips, tricks, treats, and secrets revealed on Windows 8 Microsoft is introducing a major new release of its Windows operating system, Windows 8, and what better way to learn all its ins and outs than from two internationally recognized Windows experts and Microsoft insiders, authors Paul Thurrott and Rafael Rivera? They cut through the hype to get at useful information you'll not find anywhere else, including what role this new OS plays in a mobile and tablet world. Regardless of your level of knowledge, you'll discover little-known facts about how things work, what's new and different, and h

Beginning Windows 8

CERN Document Server

Halsey, Mike

2012-01-01

Windows 8 has been described by Microsoft as its 'boldest' Windows release ever. Beginning Windows 8 takes you through the new features and helps you get more out of the familiar to reveal the possibilities for this amazing new operating system. You will learn, with non-technical language used throughout, how to get up and running in the new Windows interface, minimize downtime, maximize productivity, and harness the features you never knew existed to take control of your computer and enjoy the peace of mind and excitement that comes with it. From tips and tweaks to easy-to-follow guides and d

Windows 10 for dummies

CERN Document Server

Rathbone, Andy

2015-01-01

The fast and easy way to get up and running with Windows 10 Windows 10 For Dummies covers the latest version of Windows and gets you up and running with the changes and new features you'll find in this updated operating system. Packed with time-saving tips to help you get the most out of the software, this helpful Windows 10 guide shows you how to manage Windows tasks like navigating the interface with a mouse or touchscreen, connecting to the web, and troubleshooting problems and making quick fixes. Assuming no prior knowledge of the software, Windows 10 For Dummies addresses the updates to

Nuclear waste for NT

International Nuclear Information System (INIS)

Nelson, Brendan

2005-01-01

The Northern Territory may be powerless to block the dumping of low-level nuclear waste in the Territory under legislation introduced into Parliament by Minister for Education Science and Training, Dr Brendan Nelson, in October. Despite strong opposition to the dumping of nuclear waste in the NT, the Australian Government will be able to send waste to one of the three nominated Commonwealth-owned Defence sites within the NT under the Commonwealth Radioactive Waste Management Bill 2005 and the Commonwealth Radioactive Waste Management (Related Amendment) Bill 2005. The Bills veto recently drafted NT legislation designed to scuttle the plans. Low-level nuclear waste is stored at more than 100 sites around Australia, including hospitals, factories, universities and defence facilities. Medical isotopes produced at Lucas Heights and provided for medical procedures are the source of much of this waste, including some 16 cubic metres currently held at Darwin Hospital. Dr Nelson stressed that the Government would take all die necessary steps to comply with safety and regulatory precautions, including handling waste in line with relevant environmental, nuclear safety and proliferation safeguards

New design for photonic temporal integration with combined high processing speed and long operation time window.

Science.gov (United States)

Asghari, Mohammad H; Park, Yongwoo; Azaña, José

2011-01-17

We propose and experimentally prove a novel design for implementing photonic temporal integrators simultaneously offering a high processing bandwidth and a long operation time window, namely a large time-bandwidth product. The proposed scheme is based on concatenating in series a time-limited ultrafast photonic temporal integrator, e.g. implemented using a fiber Bragg grating (FBG), with a discrete-time (bandwidth limited) optical integrator, e.g. implemented using an optical resonant cavity. This design combines the advantages of these two previously demonstrated photonic integrator solutions, providing a processing speed as high as that of the time-limited ultrafast integrator and an operation time window fixed by the discrete-time integrator. Proof-of-concept experiments are reported using a uniform fiber Bragg grating (as the original time-limited integrator) connected in series with a bulk-optics coherent interferometers' system (as a passive 4-points discrete-time photonic temporal integrator). Using this setup, we demonstrate accurate temporal integration of complex-field optical signals with time-features as fast as ~6 ps, only limited by the processing bandwidth of the FBG integrator, over time durations as long as ~200 ps, which represents a 4-fold improvement over the operation time window (~50 ps) of the original FBG integrator.

Windows for Intel Macs

CERN Document Server

Ogasawara, Todd

2008-01-01

Even the most devoted Mac OS X user may need to use Windows XP, or may just be curious about XP and its applications. This Short Cut is a concise guide for OS X users who need to quickly get comfortable and become productive with Windows XP basics on their Macs. It covers: Security Networking ApplicationsMac users can easily install and use Windows thanks to Boot Camp and Parallels Desktop for Mac. Boot Camp lets an Intel-based Mac install and boot Windows XP on its own hard drive partition. Parallels Desktop for Mac uses virtualization technology to run Windows XP (or other operating systems

NT-pro-BNP is an independent predictor of mortality in patients with end-stage renal disease.

Science.gov (United States)

Svensson, M; Gorst-Rasmussen, A; Schmidt, E B; Jorgensen, K A; Christensen, J H

2009-04-01

Patients with end-stage renal disease (ESRD) have an increased mortality from cardiovascular disease (CVD). N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is an independent predictor of mortality in patients with ischemic heart disease and congestive heart failure. Previous data have shown markedly elevated levels of NT-pro-BNP in patients with ESRD, while the prognostic value of elevated levels of NT-pro-BNP in patients with ESRD is largely unknown. The aim of the present study was to examine if the level of NT-pro-BNP predicts mortality in patients with ERSD and CVD. We prospectively followed 206 patients with ESRD and documented CVD. Levels of NT-pro-BNP were measured at baseline, and patients were followed for 2 years or until they reached the predefined endpoint of all-cause mortality. During follow-up, the total mortality was 44% (90/206). Patients who died were followed for a median of 314 days (interquartile range 179 - 530). Using Cox regression analysis, age, female sex, systolic blood pressure, dialysis efficiency and plasma levels of NT-pro-BNP were independent prognostic risk factors of mortality. In receiver operating characteristic curve analysis a cut off value for NT-pro-BNP was determined. Patients with values of NT-pro-BNP above 12.200 pg/ml had a 3 times higher risk of death than patients below the cut-off value (HR 3.05 95% CI 1.96 - 4.77, p pro-BNP, NT-pro-BNP is still an independent predictor of mortality and might add prognostic information in patients with ESRD and documented CVD.

GA microwave window development

International Nuclear Information System (INIS)

Moeller, C.P.; Kasugai, A.; Sakamoto, K.; Takahashi, K.

1994-10-01

The GA prototype distributed window was tested in a 32 mm diam. waveguide system at a power density suitable for a MW gyrotron, using the JAERI/Toshiba 110 GHz long pulse internal converter gyrotron in the JAERI test stand. The presence of the untilted distributed window had no adverse effect on the gyrotron operation. A pulse length of 10 times the calculated thermal equilibrium time (1/e time) of 30 msec was reached, and the window passed at least 750 pulses greater than 30 msec and 343 pulses greater than 60 msec. Beyond 100 msec, the window calorimetry reached steady state, allowing the window dissipation to be measured in a single pulse. The measured loss of 4.0% agrees both with the estimated loss, on which the stress calculations are based, and with the attenuation measured at low power in the HE 11 mode. After the end of the tests, the window was examined; no evidence of arcing air coating was found in the part of the window directly illuminated by the microwaves, although there was discoloration in a recess containing an optical diagnostic which outgassed, causing a local discharge to occur in that recess. Finally, there was no failure of the metal-sapphire joints during a total operating time of 50 seconds consisting of pulses longer than 30 msec

Ribosomal protein NtRPL17 interacts with kinesin-12 family protein NtKRP and functions in the regulation of embryo/seed size and radicle growth.

Science.gov (United States)

Tian, Shujuan; Wu, Jingjing; Liu, Yuan; Huang, Xiaorong; Li, Fen; Wang, Zhaodan; Sun, Meng-Xiang

2017-11-28

We previously reported that a novel motor protein belonging to the kinesin-12 family, NtKRP, displays critical roles in regulating embryo and seed size establishment. However, it remains unknown exactly how NtKRP contributes to this developmental process. Here, we report that a 60S ribosomal protein NtRPL17 directly interacts with NtKRP. The phenotypes of NtRPL17 RNAi lines show notable embryo and seed size reduction. Structural observations of the NtRPL17-silenced embryos/seeds reveal that the embryo size reduction is due to a decrease in cell number. In these embryos, cell division cycle progression is delayed at the G2/M transition. These phenotypes are similar to that in NtKRP-silenced embryos/seeds, indicating that NtKRP and NtRPL17 function as partners in the same regulatory pathway during seed development and specifically regulate cell cycle progression to control embryo/seed size. This work reveals that NtRPL17, as a widely distributed ribosomal protein, plays a critical role in seed development and provides a new clue in the regulation of seed size. Confirmation of the interaction between NtKRP and NtRPL17 and their co-function in the control of the cell cycle also suggests that the mechanism might be conserved in both plants and animals. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology.

SPSS 9.0 for Windows 98/NT统计软件包简介

Institute of Scientific and Technical Information of China (English)

李志辉; 洪楠

2000-01-01

@@ SPSS(Statistical Package for the Social Science)是由美国SPSS公司自80年代初开发的大型统计学软件包.1998年推出的SPSS 9.0版本,除保持了以往SPSS的诸多优点以外,还汇集了SAS for Windows[1,2]与STATISTICA for Windows95/NT[3,4]的长处,是当今世界上最新、最流行、最受欢迎的统计软件包之一.与SPSS 7.5比较,SPSS 9.0具有以下新的特点[5].

Life prediction and mechanical reliability of NT551 silicon nitride

Science.gov (United States)

Andrews, Mark Jay

The inert strength and fatigue performance of a diesel engine exhaust valve made from silicon nitride (Si3N4) ceramic were assessed. The Si3N4 characterized in this study was manufactured by Saint Gobain/Norton Industrial Ceramics and was designated as NT551. The evaluation was made utilizing a probabilistic life prediction algorithm that combined censored test specimen strength data with a Weibull distribution function and the stress field of the ceramic valve obtained from finite element analysis. The major assumptions of the life prediction algorithm are that the bulk ceramic material is isotropic and homogeneous and that the strength-limiting flaws are uniformly distributed. The results from mechanical testing indicated that NT551 was not a homogeneous ceramic and that its strength were functions of temperature, loading rate, and machining orientation. Fractographic analysis identified four different failure modes; 2 were identified as inhomogeneities that were located throughout the bulk of NT551 and were due to processing operations. The fractographic analysis concluded that the strength degradation of NT551 observed from the temperature and loading rate test parameters was due to a change of state that occurred in its secondary phase. Pristine and engine-tested valves made from NT551 were loaded to failure and the inert strengths were obtained. Fractographic analysis of the valves identified the same four failure mechanisms as found with the test specimens. The fatigue performance and the inert strength of the Si3N 4 valves were assessed from censored and uncensored test specimen strength data, respectively. The inert strength failure probability predictions were compared to the inert strength of the Si3N4 valves. The inert strength failure probability predictions were more conservative than the strength of the valves. The lack of correlation between predicted and actual valve strength was due to the nonuniform distribution of inhomogeneities present in NT

Use of the decision support system RECASS NT (Radio Ecological Analysis Support System) for anti terrorism actions

International Nuclear Information System (INIS)

Bulgakov, V.G.; Gariyants, A.M.; Kosykh, V.S.; Shershakov, V.M.

2006-01-01

Decision support system RECASS NT (Radio Ecological Analysis Support System) was developed and is still enhancing in Federal Service Roshydromet for providing on-line estimates and prognoses of radiation and chemical situation in the event of an emergency, including acts of terrorism, as well as to estimate transboundary pollutants transport. RECASS NT has been installed at all ten NPPs of the Russian Federation, in Crisis Centers of Roshydromet, concern Rosenergoatom and Minatom, at plants for destroying chemical weapons. The paper describes the structure of RECASS NT system and discuss its possible application in case of an emergency on examples of using the system during radiation emergency response exercises at NPPs. RECASS NT can be used for developing recommendations regarding time when anti terrorism operations are better to be started with a view to minimize damage

Beginning Windows 8.1

CERN Document Server

Halsey, Mike

2013-01-01

Windows 8 has been described by Microsoft as its 'boldest' Windows release ever and the 8.1 update enhances the paradigm further. Beginning Windows 8.1 takes you through the new features and helps you get more out of the familiar to reveal the fullest possibilities for this amazing new operating system. You will learn, with non-technical language used throughout, how to get up and running in the new Windows interface, minimize downtime, maximize productivity, and harness the features you never knew existed to take control of your computer and enjoy the peace of mind and excitement that comes w

NT-proBNP

DEFF Research Database (Denmark)

Andersen, Charlotte; Mellemkjær, Søren; Hilberg, Ole

2016-01-01

BACKGROUND: Pulmonary hypertension (PH) is a serious complication to interstitial lung disease (ILD) and has a poor prognosis. PH is often diagnosed by screening with echocardiography followed by right heart catheterisation. A previous study has shown that a value of NT-pro-brain natriuretic...

NT-proBNP concentrations in mountain marathoners.

Science.gov (United States)

Banfi, Giuseppe; Lippi, Giuseppe; Susta, Daniele; Barassi, Alessandra; D'Eril, Gianvico Melzi; Dogliotti, Giada; Corsi, Massimiliano M

2010-05-01

The 76 amino acid N-terminal proB-type natriuretic peptide (NT-proBNP) is proposed for evaluating and monitoring heart pathologies characterized by myocardial wall stress. Strenuous exercise might generate transitory ischemia, myocardial stress, and diastolic left ventricular dysfunction, possibly inducing an increase of some biochemical parameter concentrations. An alert has been claimed owing to biochemical and instrumental signs of heart dysfunction in recreational athletes during marathon races. We studied the behaviour of NT-proBNP in 15 mountain marathoners before and after a race. The concentrations of the parameter were lower than that observed in controls at rest and were similar to that observed in professional soccer and rugby players. The concentrations significantly increased after the race. NT-proBNP is low at rest in professional athletes, and the increase after physical exercise is physiological. The marathoners, even when performing races in a high-altitude environment, show NT-proBNP concentrations similar to those of athletes from other sports disciplines, characterized by low levels of effort and by a mix of aerobic and anaerobic metabolism. The increase of NT-proBNP is linked to strenuous physical exercise and to heavy heart effort, testified also by an increase of troponin I. However, the role of the NT-proBNP could be important to screen recreational and professional marathoners to avoid possible heart problems and sudden cardiac death in subjects with occult heart disease. The results of the present study are relevant to the design and evaluation of training programs for improving strength and function of professional marathoners.

Windows Home Server users guide

CERN Document Server

Edney, Andrew

2008-01-01

Windows Home Server brings the idea of centralized storage, backup and computer management out of the enterprise and into the home. Windows Home Server is built for people with multiple computers at home and helps to synchronize them, keep them updated, stream media between them, and back them up centrally. Built on a similar foundation as the Microsoft server operating products, it's essentially Small Business Server for the home.This book details how to install, configure, and use Windows Home Server and explains how to connect to and manage different clients such as Windows XP, Windows Vist

Sincronización de Células de Tabaco (Nicotiana tabacum) NT-1 Synchronization of tobacco cells (Nicotiana tabacum) NT-1

OpenAIRE

León F Ruiz; Ana E Higareda; Marco A Pardo

2010-01-01

Se ha evaluado la capacidad sincronizante de afidicolina e hidroxiurea en cultivos de células de tabaco (Nicotiana tabacum) NT-1. Los cultivos sincronizados son poderosas herramientas en estudios moleculares y bioquímicos relacionados al ciclo celular y comúnmente se utilizan químicos para bloquear el ciclo celular. La línea celular de tabaco (Nicotiana tabacum) NT-1 proviene de la línea celular TBY-2, caracterizándose NT-1 por su menor velocidad de crecimiento y tamaño celular heterogéneo. L...

Windows XP ends its life at CERN – register for Windows 7 training!

CERN Multimedia

Michał Kwiatek (IT-OIS)

2012-01-01

Windows XP has been around for over 10 years and it is now time to move on. At CERN, general support for Windows XP will end in December 2012, and before this date users are requested to schedule a migration to the next version of Windows – Windows 7.   Windows 7 is already well established at CERN – it is used by a large majority of users. In fact, there was a considerable user demand even before its official release in October 2009 and its adoption has been smooth. Users praise Windows 7 for its improved stability and a clear advantage on laptops is a much more efficient implementation of offline files. The migration to Windows 7 involves a reinstallation of the operating system. Files stored in user home folders on DFS will be immediately available after the reinstallation. Applications will be upgraded to more recent versions and in certain cases, an application may even be replaced by another application providing the same functionality. Microsoft Office suite is a good ...

The technical standard IBAMA (NT01/11) and its applications in waste water treatment in offshore platforms; A NT/ 01/11 do IBAMA e suas aplicacoes no tratamento de efluentes nas plataformas offshore

Energy Technology Data Exchange (ETDEWEB)

Paravidino, Thadeu Crespo; Miocque, Andre; Oliveira, Cristiane Lopes de [Vicel Comercio e Industria e Servico Ltda., Rio de Janeiro, RJ (Brazil)

2012-07-01

This paper aims to present the technical standard IBAMA (NT01/11) as it applies to wastewater treatment projects in maritime exploration and production of oil and gas, and the solutions proposed by the company VICEL to meet with this standard and the other existing laws in force in Brazil. To meet these objectives, the paper covers the following topics: environmental legislation applicable to maritime enterprises of exploration and production of oil and gas operating in Brazil: concepts and definitions of MARPOL and CONAMA Resolution 357 (amended by CONAMA 430), Law 9966/2000 and NT01/11; PCP - Pollution Control Project required by IBAMA; the solutions proposed by VICEL - Gray Water Policy Management and Treatment System (GWTS). Throughout its development, this paper presents in detail the analysis of the gray water effluents generated on board of a drilling rig, and the results obtained with the installation of a prototype system for treating gray water (GWTS). Finally, this paper demonstrates that IBAMA NT01/11 regulation is intended to guide and create means for monitoring all maritime enterprises of exploration and production of oil and gas operating in Brazil, in order to promote the reduction of the pollution caused by their operation (ecological footprint), concludes as compulsory the treatment for the gray water generated on board, and presents VICEL solutions for the implementation of a waste management policy and the installation of a Gray Water Treatment System (GWTS). (author)

Aerodynamic window for a laser fusion device

International Nuclear Information System (INIS)

Masuda, Wataru

1983-01-01

Since the window of a laser system absorbs a part of the laser energy, the output power is determined by the characteristics of the window. The use of an aerodynamic window has been studied. The required characteristics are to keep the large pressure difference. An equation of motion of a vortex was presented and analyzed. The operation power of the system was studied. A multi-stage aerodynamic window was proposed to reduce the power. When the jet flow of 0.3 of the Mach number is used, the operation power will be several Megawatt, and the length of an optical path will be about 100 m. (Kato, T.)

Relationship between CCR and NT-proBNP in Chinese HF patients, and their correlations with severity of HF.

Science.gov (United States)

Lu, Zhigang; Wang, Bo; Wang, Yunliang; Qian, Xueqing; Zheng, Wei; Wei, Meng

2014-01-01

To evaluate the relationship between creatinine clearance rate (CCR) and the level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in heart failure (HF) patients and their correlations with HF severity. Two hundred and one Chinese patients were grouped according to the New York Heart Association (NYHA) classification as NYHA 1-2 and 3-4 groups and 135 cases out of heart failure patients as control group. The following variables were compared among these three groups: age, sex, body mass index (BMI), smoking status, hypertension, diabetes, NT-proBNP, creatinine (Cr), uric acid (UA), left ventricular end-diastolic diameter (LVEDD), and CCR. The biomarkers of NT-proBNP, Cr, UA, LVEDD, and CCR varied significantly in the three groups, and these variables were positively correlated with the NHYA classification. The levels of NT-proBNP and CCR were closely related to the occurrence of HF and were independent risk factors for HF. At the same time, there was a significant negative correlation between the levels of NT-proBNP and CCR. The area under the receiver operating characteristic curve suggested that the NT-proBNP and CCR have high accuracy for diagnosis of HF and have clinical diagnostic value. NT-proBNP and CCR may be important biomarkers in evaluating the severity of HF.

Adaptive Liquid Crystal Windows

Energy Technology Data Exchange (ETDEWEB)

Taheri, Bahman; Bodnar, Volodymyr

2011-12-31

Energy consumption by private and commercial sectors in the U.S. has steadily grown over the last decade. The uncertainty in future availability of imported oil, on which the energy consumption relies strongly, resulted in a dramatic increase in the cost of energy. About 20% of this consumption are used to heat and cool houses and commercial buildings. To reduce dependence on the foreign oil and cut down emission of greenhouse gases, it is necessary to eliminate losses and reduce total energy consumption by buildings. To achieve this goal it is necessary to redefine the role of the conventional windows. At a minimum, windows should stop being a source for energy loss. Ideally, windows should become a source of energy, providing net gain to reduce energy used to heat and cool homes. It is possible to have a net energy gain from a window if its light transmission can be dynamically altered, ideally electronically without the need of operator assistance, providing optimal control of the solar gain that varies with season and climate in the U.S. In addition, the window must not require power from the building for operation. Resolution of this problem is a societal challenge and of national interest and will have a broad global impact. For this purpose, the year-round, allclimate window solution to provide an electronically variable solar heat gain coefficient (SHGC) with a wide dynamic range is needed. AlphaMicron, Inc. (AMI) developed and manufactured 1ft × 1ft prototype panels for the world’s first auto-adjusting Adaptive Liquid Crystal Windows (ALCWs) that can operate from sunlight without the need for external power source and demonstrate an electronically adjustable SHGC. This novel windows are based on AlphaMicron’s patented e-Tint® technology, a guesthost liquid crystal system implemented on flexible, optically clear plastic films. This technology is suitable both for OEM and aftermarket (retro-fitting) lamination to new and existing windows. Low level of

Understanding Windows | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Differential ontogenetic patterns of levocabastine-sensitive neurotensin NT2 receptors and of NT1 receptors in the rat brain revealed by in situ hybridization.

Science.gov (United States)

Lépée-Lorgeoux, I; Betancur, C; Rostène, W; Pélaprat, D

1999-03-12

The postnatal ontogeny of the levocabastine-sensitive neurotensin receptor (NT2) mRNA was studied by in situ hybridization in the rat brain and compared with the distribution of the levocabastine-insensitive NT1 receptor. NT2 receptor mRNA was absent at birth from all brain structures except the ependymal cell layer lining the ventricles. The development of NT2 receptor mRNA followed three ontogenetic patterns. The first pattern, involving the majority of the cerebral gray matter, was characterized by a continuous increase from postnatal day 5 (P5) to P30. The second one, involving regions rich in myelinated fibers such as the corpus callosum and lacunosum moleculare layer of the hippocampus, exhibited a pronounced increase between P5 and P10, peaked at P15 and was followed by a plateau or a slight decrease. The third pattern was observed in the ependymal cell layer lining the olfactory and lateral ventricles, where the high labeling already present at birth continued to increase during development. These different developmental patterns could reflect the variety of cells expressing NT2 receptor mRNA, including neurons, protoplasmic astrocytes in gray matter, fibrous astrocytes present in myelinated fibers tracts, and ependymal cells. In contrast, NT1 receptor mRNA, which seems to be associated only with neurons, was highly and transiently expressed during the perinatal period in the cerebral cortex, hippocampus and striatal neuroepithelium. Other regions, notably the ventral tegmental area and substantia nigra compacta, exhibited a gradual increase in NT1 receptor signal, reaching adult levels by P21. Both the differential localization and ontogenetic profiles of NT1 and NT2 receptor mRNAs suggest different involvement of these two receptors in brain functions and development. Copyright 1999 Elsevier Science B.V.

The prognostic value of individual NT-proBNP values in chronic heart failure does not change with advancing age.

Science.gov (United States)

Frankenstein, L; Clark, A L; Goode, K; Ingle, L; Remppis, A; Schellberg, D; Grabs, F; Nelles, M; Cleland, J G F; Katus, H A; Zugck, C

2009-05-01

It is unclear whether age-related increases in N-terminal pro-brain natriuretic peptide (NT-proBNP) represent a normal physiological process-possibly affecting the prognostic power-of NT-proBNP-or reflect age-related subclinical pathological changes. To determine the effect of age on the short-term prognostic value of NT-proBNP in patients with chronic heart failure (CHF). Prospective observational study with inclusion and matching of consecutive patients aged >65 years (mean (SD) 73.1 (6.0) years) to patients <65 years (53.7 (8.6) years) with respect to NT-proBNP, New York Heart Association stage, sex and aetiology of CHF (final n = 443). University hospital outpatient departments in the UK and Germany. Chronic stable heart failure due to systolic left ventricular dysfunction. None. All-cause mortality. In both age groups, NT-proBNP was a significant univariate predictor of mortality, and independent of age, sex and other established risk markers. The prognostic information given by NT-proBNP was comparable between the two groups, as reflected by the 1-year mortality of 9% in both groups. The prognostic accuracy of NT-proBNP as judged by the area under the receiver operating characteristics curve for the prediction of 1-year mortality was comparable for elderly and younger patients (0.67 vs 0.71; p = 0.09). NT-proBNP reflects disease severity in elderly and younger patients alike. In patients with chronic stable heart failure, the NT-proBNP value carries the same 1-year prognostic information regardless of the age of the patient.

Linear flow dynamics near a T/NT interface

Science.gov (United States)

Teixeira, Miguel; Silva, Carlos

2011-11-01

The characteristics of a suddenly-inserted T/NT interface separating a homogeneous and isotropic shear-free turbulence region from a non-turbulent flow region are investigated using rapid distortion theory (RDT), taking full account of viscous effects. Profiles of the velocity variances, TKE, viscous dissipation rate, turbulence length scales, and pressure statistics are derived, showing very good agreement with DNS. The normalized inviscid flow statistics at the T/NT interface do not depend on the form of the assumed TKE spectrum. In the non-turbulent region, where the flow is irrotational (except within a thin viscous boundary layer), the dissipation rate decays as z-6, where z is distance from the T/NT interface. The mean pressure exhibits a decrease towards the turbulence due to the associated velocity fluctuations, consistent with the generation of a mean entrainment velocity. The vorticity variance and dissipation rate display large maxima at the T/NT interface due to the existing inviscid discontinuities of the tangential velocity, and these maxima are quantitatively related to the thickness of the viscous boundary layer (VBL). At equilibrium, RDT suggests that the thickness of the T/NT interface scales on the Kolmogorov microscale. We acknowledge the financial support of FCT under Project PTDC/EME-MFE/099636/2008.

Best management practices and work plan for installation of and monitoring at temporary weirs and flumes at NT-3, NT-4, and NT-5 Oak Ridge Y-12 Plant, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

1998-02-01

This Best Management Practices (BMP) and Work Plan has been developed in order to maintain compliance with applicable regulatory requirements by documenting the practices that are required during the installation and maintenance of temporary weirs and flumes at the NT-3, NT-4, and NT-5 tributaries, subsequent collection of water discharge data, and removal of the weirs and flumes. The practices included in this BMP comply with the Clean Water Act and the intent of Sect. 70-8-104(b) of the Tennessee Code Annotated: Tennessee Wildlife Resources Commission Proclamation 94-16 to prevent the destruction of the habitat of state-listed wildlife species that are designated as open-quotes in need of management.close quotes

Frit Development Efforts for Sludge Batch 4 (SB4): Operating Window Assessments of Scenarios Leading Up to the Selected Preparation Plan for SB4

International Nuclear Information System (INIS)

Peeler, D

2006-01-01

The objective of this report is to document technical information that has been provided to Defense Waste Processing Facility (DWPF) and Closure Business Unit (CBU) personnel as part of the frit development support for Sludge Batch 4 (SB4). The information presented in this report includes projected operating windows (expressed in terms of waste loading) for various sludge blending and/or washing options coupled with candidate frits of interest. Although the Nominal Stage assessment serves as the primary tool for these evaluations, select systems were also evaluated using a Variation Stage assessment in which compositional variations were introduced. In addition, assessments of the impacts of nepheline formation potential and the SO 4 - solubility limit on the projected operating windows are also provided. Although this information was used as part of the technical basis leading to CBU's development of the preferred SB4 preparation plan, none of the options presented in this report was selected as the preferred plan. Therefore, the information is presented without significant interpretation of the resulting operating windows, but the projected windows are provided so additional insight can be explored if desired. Detailed assessments of the projected operating windows (using both Nominal and Variation Stage assessments) of the preferred sludge preparation plan with candidate frits are to be documented elsewhere. The information provided in this report is focused solely on model-based projections of the operating windows for various SB4 blending strategies of interest. Although nepheline formation potential is monitored via model predictions as a part of this assessment, experimental work investigating the impact of nepheline on glass quality is also being addressed in a parallel study. The results of this paper study and the experimental assessments of melt rate, SO 4 solubility, and/or nepheline formation potential are all critical components of the inputs into

Windows 8.1 for dummies

CERN Document Server

Rathbone, Andy

2013-01-01

The bestselling book on Windows, now updated for the new 8.1 features Microsoft has fine-tuned Windows 8 with some important new features, and veteran author Andy Rathbone explains every one in this all-new edition of a long-time bestseller. Whether you're using Windows for the first time, upgrading from an older version, or just moving from Windows 8 to 8.1, here's what you need to know. Learn about the dual interfaces, the new Start button, how to customize the interface and boot operations, and how to work with programs and files, use the web and social media, manage music and photos, and

Windows 7 the definitive guide

CERN Document Server

Stanek, William R

2010-01-01

This book provides everything you need to manage and maintain Windows 7. You'll learn all of the features and enhancements in complete detail, along with specifics for configuring the operating system to put you in full control. Bestselling author and Windows expert William Stanek doesn't just show you the steps you need to follow, he also tells you how features work, why they work, and how you can customize them to meet your needs. Learn how to squeeze every bit of power out of Windows 7 to take full advantage of its features and programs. Set up, customize, and tune Windows 7-Optimize its

A continuous wave RF vacuum window

International Nuclear Information System (INIS)

Walton, R.

1999-09-01

An essential part of an ICRF system to be used in fusion reactor is the RF window. This is fitted in a coaxial transmission line. It forms a vacuum and tritium boundary between the antenna, situated inside the machine, and the transmission line, which feeds it. A double window is required with a vacuum inter-space. The dielectric, which forms the vacuum boundary, must be brazed into its housing. The window must be of a robust construction, and capable of withstanding both axial and radial loads. The vacuum boundaries should be thick walled in order act as a suitable tritium barrier. A further requirement is that the window is capable of continuous operation. The design of such a window is presented below. A half scale prototype has been manufactured, which has successfully completed RF, vacuum, and mechanical testing at JET, but has no water cooling, which is a requirement for continuous operation. The design presented here is for a window to match the existing 30 Ω main transmission lines at JET. It employs two opposed ceramic dielectric cones with a much increased angle of incidence compared with existing JET windows. The housing is machined from titanium. Small corona rings are used, and the tracking distance along the ceramic surface is large. The geometry minimizes the peak electric field strength. The design uses substantial pre-stressing during manufacture, to produce a compressive stress field throughout the dielectric material. Significant tensile stresses in the ceramic, and therefore the possibility of fracture due to applied thermal and mechanical loading, are eliminated in this way. A full-scale actively cooled RF window using this basic design should be capable of continuous use at 50 kV in the 20 - 90 MHz range. A half scale, inertially cooled prototype window has been designed, built and tested successfully at JET to 48 kV for up to 20 seconds. The prototype uses alumina for the dielectric, whereas beryllia is more appropriate for continuous

Exam 70-411 administering Windows Server 2012

CERN Document Server

Course, Microsoft Official Academic

2014-01-01

Microsoft Windows Server is a multi-purpose server designed to increase reliability and flexibility of  a network infrastructure. Windows Server is the paramount tool used by enterprises in their datacenter and desktop strategy. The most recent versions of Windows Server also provide both server and client virtualization. Its ubiquity in the enterprise results in the need for networking professionals who know how to plan, design, implement, operate, and troubleshoot networks relying on Windows Server. Microsoft Learning is preparing the next round of its Windows Server Certification program

Comparison of Abbott AxSYM and Roche Elecsys 2010 for measurement of BNP and NT-proBNP.

Science.gov (United States)

Chien, Tzu-I; Chen, Hui-Hou; Kao, Jau-Tsuen

2006-07-15

B-type natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) are small cardiac hormones released from the heart. They can be used as an important aid to diagnose congestive heart failure (CHF). We compared the performances of the Abbott AxSYM and Roche Elecsys 2010 for the measurement of BNP and NT-proBNP. The first method uses a microparticle enzyme-linked immunoassay, whereas the other uses chemiluminescent immunometric assay. The CVs using pooled sera ranged from 3.7% to 12.7% for the AxSYM and 0.9% to 2.2% for the Elecsys 2010. The Passing and Bablok regression was Elecsys 2010 NT-proBNP=7.23xAxSYM BNP+2.53. The BNP in EDTA plasma was more stable than in serum. The immunoreactivity difference of NT-proBNP in serum or EDTA plasma was within 10% when stored at 4 degrees Celsius or 25 degrees Celsius for 72 h. Receiver operating characteristic (ROC) curves were different for both assays, and the areas under the curves were 0.704 and 0.841 for the AxSYM and Elecsys 2010 method, respectively. Both assays were not entirely specific for heart failure. The precision and stability for NT-proBNP was better than for BNP in serum. It is important to use method-appropriate reference ranges (or cutoff) for the BNP and NT-proBNP, respectively, in the assessment of CHF.

Window Glazing Types | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Window Frame Types | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Windows 7 A quick, hands-on introduction

CERN Document Server

Lee, Wei-Meng

2009-01-01

This compact book offers the quickest path for Windows users to get started with Microsoft's Windows 7 operating system. You get the essential information you need to upgrade or install the system and configure it to fit your activities, along with a tour of Windows 7's features and built-in applications. Microsoft has learned from the mistakes of Windows Vista, and Windows 7 shows it-this new OS is much faster and more stable. With Windows 7: Up and Running, you'll learn what's new and what's changed from XP and Vista, and get advice on ways to use this system for work, entertainment, inst

Windows 8.1 for seniors for dummies

CERN Document Server

Weverka, Peter

2013-01-01

Seniors, here's what you need to get up and running on Windows 8.1 Microsoft, now a little older and wiser, is back with Windows 8.1, the revamped version that brings fresh changes and welcome improvements to the Windows 8 operating system. And now you savvy seniors can get the very most out of this easier-to-use Windows 8.1 with our friendly new guide. Using large print that makes the book easier to read plus magnified screen shots to help make Windows less intimidating, this book walks you through common tasks and show you how to get things done in fine style. Helps you get to know Windows

Particulated articular cartilage: CAIS and DeNovo NT.

Science.gov (United States)

Farr, Jack; Cole, Brian J; Sherman, Seth; Karas, Vasili

2012-03-01

Cartilage Autograft Implantation System (CAIS; DePuy/Mitek, Raynham, MA) and DeNovo Natural Tissue (NT; ISTO, St. Louis, MO) are novel treatment options for focal articular cartilage defects in the knee. These methods involve the implantation of particulated articular cartilage from either autograft or juvenile allograft donor, respectively. In the laboratory and in animal models, both CAIS and DeNovo NT have demonstrated the ability of the transplanted cartilage cells to "escape" from the extracellular matrix, migrate, multiply, and form a new hyaline-like cartilage tissue matrix that integrates with the surrounding host tissue. In clinical practice, the technique for both CAIS and DeNovo NT is straightforward, requiring only a single surgery to affect cartilage repair. Clinical experience is limited, with short-term studies demonstrating both procedures to be safe, feasible, and effective, with improvements in subjective patient scores, and with magnetic resonance imaging evidence of good defect fill. While these treatment options appear promising, prospective randomized controlled studies are necessary to refine the indications and contraindications for both CAIS and DeNovo NT.

Windows Phone 7 Made Simple

CERN Document Server

Trautschold, Martin

2011-01-01

With Windows Phone 7, Microsoft has created a completely new smartphone operating system that focuses on allowing users to be productive with their smartphone in new ways, while offering seamless integration and use of Microsoft Office Mobile as well as other productivity apps available in the Microsoft App Store. Windows Phone 7 Made Simple offers a clear, visual, step-by-step approach to using your Windows Phone 7 smartphone, no matter what the manufacturer. Author Jon Westfall is an expert in mobile devices, recognized by Microsoft as a "Most Valuable Professional" with experience

A CoGeNT confirmation of the DAMA signal

International Nuclear Information System (INIS)

Foot, R.

2010-01-01

The CoGeNT Collaboration has recently reported a rising low energy spectrum in their ultra low noise Germanium detector. This is particularly interesting as the energy range probed by CoGeNT overlaps with the energy region in which DAMA has observed their annual modulation signal. We show that the mirror dark matter candidate can simultaneously explain both the DAMA annual modulation signal and the rising low energy spectrum observed by CoGeNT. This constitutes a model dependent confirmation of the DAMA signal and adds weight to the mirror dark matter paradigm.

Windows Calorimeter Control (WinCal) system configuration control board (SCCB) operating procedure

International Nuclear Information System (INIS)

Westsik, G.A.

1997-01-01

This document describes the operating procedure for the System Configuration Control Board (SCCB) performed in support of the Windows Calorimeter Control (WinCal) system. This board will consist of representatives from Babcock and Wilcox Hanford Company Babcock and Wilcox Protec, Inc.; and Lockheed Martin Services, Inc. In accordance with agreements for the joint use of the Babcock and Wilcox Hanford Company calorimeters located in the Hanford Site Plutonium Finishing Plant (PFP) Nondestructive Assay Laboratory, concurrence regarding changes to the WinCal system will be obtained from the International Atomic Energy Agency (IAEA). Further, changes to the WinCal software will be communicated to Los Alamos National Laboratory

Reduced field TE01 X-Band traveling wave window

International Nuclear Information System (INIS)

Fowkes, W.R.; Callin, R.S.; Tantawi, S.G.; Wright, E.L.

1995-01-01

The RF electric field is reduced by more than a factor of two using a pair of symmetrically located irises in a new type of klystron window operating in the TE 01 mode at X-Band. The advantages of this window over the usual TE 01 half-wave resonant window are discussed as well as theory and operating results. Ultra high purity alumina formed by the HIP process is used. This window has been successfully tested at 100 MW with a 1.5 microsecond RF pulse width and is being used on the XL series klystrons

Rise and fall of NT-proBNP in aortic valve intervention.

Science.gov (United States)

Hultkvist, Henrik; Holm, Jonas; Svedjeholm, Rolf; Vánky, Farkas

2018-01-01

To describe the dynamics of N-terminal pro-B-type natriuretic peptide (NT-proBNP) from preoperative evaluation to 6-month follow-up in patients undergoing aortic valve intervention, and to evaluate NT-proBNP with regard to 1-year mortality. At preoperative evaluation, we prospectively included 462 patients accepted for aortic valve intervention. The median time to surgical aortic valve replacement (SAVR; n=336) or transcatheter aortic valve implantation (TAVI; n=126) was 4 months. NT-proBNP was measured at enrolment for preoperative evaluation, on the day of surgery, postoperatively on day 1, day 3 and at the 6-month follow-up. Subgroups of patients undergoing SAVR with aortic regurgitation and aortic stenosis with and without coronary artery bypass were also analysed. NT-proBNP remained stable in all subgroups during the preoperative waiting period, but displayed a substantial transient early postoperative increase with a peak on day 3 except in the TAVI group, which peaked on day 1. At the 6-month follow-up, NT-proBNP had decreased to or below the preoperative level in all groups. In the SAVR group, NT-proBNP preoperatively and on postoperative days 1 and 3 revealed significant discriminatory power with regard to 1-year mortality (area under the curve (AUC)=0.79, P=0.0001; AUC=0.71, P=0.03; and AUC=0.79, P=0.002, respectively). This was not found in the TAVI group, which had higher levels of NT-proBNP both preoperatively and at the 6-month follow-up compared with the SAVR group. The dynamic profile of NT-proBNP differed between patients undergoing TAVI and SAVR. NT-proBNP in the perioperative course was associated with increased risk of 1-year mortality in SAVR but not in TAVI.

Big Book of Windows Hacks

CERN Document Server

Gralla, Preston

2008-01-01

Bigger, better, and broader in scope, the Big Book of Windows Hacks gives you everything you need to get the most out of your Windows Vista or XP system, including its related applications and the hardware it runs on or connects to. Whether you want to tweak Vista's Aero interface, build customized sidebar gadgets and run them from a USB key, or hack the "unhackable" screensavers, you'll find quick and ingenious ways to bend these recalcitrant operating systems to your will. The Big Book of Windows Hacks focuses on Vista, the new bad boy on Microsoft's block, with hacks and workarounds that

Windows 8 visual quick tips

CERN Document Server

McFedries, Paul

2012-01-01

Easy-in, easy-out format covers all the bells and whistles of Windows 8 If you want to learn how to work smarter and faster in Microsoft's Windows 8 operating system, this easy-to-use, compact guide delivers the goods. Designed for visual learners, it features short explanations and full-color screen shots on almost every page, and it's packed with timesaving tips and helpful productivity tricks. From enhancing performance and managing digital content to setting up security and much more, this handy guide will help you get more out of Windows 8. Uses full-color screen shots and short, step-by-

Windows 8 app projects XAML and C#

CERN Document Server

Vermeir, Nico

2013-01-01

Become a leading Windows 8 app developer by using Windows 8 App Projects - XAML and C# Edition to learn techniques, tools, and ideas to create successful, 5-star apps. Windows 8 App Projects - XAML and C# Edition shows you the nuts and bolts of the Windows 8 development ecosystem. Then, through a series of example driven chapters, you'll discover how to leverage the platform's unique features. With each project, you'll be one step closer to building full-featured, responsive, and well designed apps that feel like they're a part of the operating system. Windows 8 App Projects - XAML and C# Edit

Windows 7 Tweaks A Comprehensive Guide on Customizing, Increasing Performance, and Securing Microsoft Windows 7

CERN Document Server

Sinchak, Steve

2009-01-01

The definitive guide to unlocking the hidden potential of the Windows 7 OS. Written by bestselling author and the creator of tweaks.com Steve Sinchak, this unique guide provides you with the ultimate collection of hidden gems that will enable you to get the most out of Windows 7. Packed with more than 400 pages of insider tips, the book delves beneath the surface to reveal little-known ways to tweak, modify, and customize Windows 7 so you can get every ounce of performance from your operating system. Regardless of your experience with tweaking your system, you'll find fascinating and fun tips

Changes in Air CO2 Concentration Differentially Alter Transcript Levels of NtAQP1 and NtPIP2;1 Aquaporin Genes in Tobacco Leaves

Directory of Open Access Journals (Sweden)

Francesca Secchi

2016-04-01

Full Text Available The aquaporin specific control on water versus carbon pathways in leaves is pivotal in controlling gas exchange and leaf hydraulics. We investigated whether Nicotiana tabacum aquaporin 1 (NtAQP1 and Nicotiana tabacum plasma membrane intrinsic protein 2;1 (NtPIP2;1 gene expression varies in tobacco leaves subjected to treatments with different CO2 concentrations (ranging from 0 to 800 ppm, inducing changes in photosynthesis, stomatal regulation and water evaporation from the leaf. Changes in air CO2 concentration ([CO2] affected net photosynthesis (Pn and leaf substomatal [CO2] (Ci. Pn was slightly negative at 0 ppm air CO2; it was one-third that of ambient controls at 200 ppm, and not different from controls at 800 ppm. Leaves fed with 800 ppm [CO2] showed one-third reduced stomatal conductance (gs and transpiration (E, and their gs was in turn slightly lower than in 200 ppm– and in 0 ppm–treated leaves. The 800 ppm air [CO2] strongly impaired both NtAQP1 and NtPIP2;1 gene expression, whereas 0 ppm air [CO2], a concentration below any in vivo possible conditions and specifically chosen to maximize the gene expression alteration, increased only the NtAQP1 transcript level. We propose that NtAQP1 expression, an aquaporin devoted to CO2 transport, positively responds to CO2 scarcity in the air in the whole range 0–800 ppm. On the contrary, expression of NtPIP2;1, an aquaporin not devoted to CO2 transport, is related to water balance in the leaf, and changes in parallel with gs. These observations fit in a model where upregulation of leaf aquaporins is activated at low Ci, while downregulation occurs when high Ci saturates photosynthesis and causes stomatal closure.

Proper Installation of Replacement Windows | Efficient Windows

Science.gov (United States)

Collaborative Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring

Modelling window opening behaviour in Danish dwellings

DEFF Research Database (Denmark)

Andersen, Rune Vinther; Olesen, Bjarne W.; Toftum, Jørn

2011-01-01

In this paper we present and analyse data from two studies of window opening behaviour in residential buildings in Denmark. Based on measurements of indoor environment, weather and window opening behaviour in 15 dwellings, we propose a model that will predict window opening behaviour. The data...... showed that other factors than thermal effects impact the behaviour of the occupants. Some of these factors were included in the model. We present data from repeated questionnaire surveys that show that occupants tend to adjust heating setpoints, adjust clothing and operate windows when feeling thermally...

Performance Standards for Windows | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Benefits of Efficient Windows | Efficient Windows Collaborative

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Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Assessing Window Replacement Options | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Windows for New Construction | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Information decision making support system RECASS-NT

International Nuclear Information System (INIS)

Shershakov, V.; Kosykh, V.; Borodin, R.

2003-01-01

Full text: The primary purpose of the DSS RECASS-NT is analysis and prediction of the situation in case of emergency at nuclear facilities (in early phases of an accident) including dose estimation and working out recommendations with regard to countermeasures to protect the public affected by the accident. The system was created to satisfy the following requirements: the system should be ale to operate in two modes: automatic and interactive; the system is based an the 'client-server' principle. Clients can interact with the system both locally and remotely; all calculations in the system are carried out on the server. The client part is responsible for interaction with the system user (including data presentation). Results of model calculations can be displayed during modeling (dynamically) and on completion of calculations; the information base of the system is the operational database, the systemic database and the database with calculation results; the system should enable parallel calculations, among them calculations by different scenarios for the same accident. The automatic mode involves running a specified chain of modules using appropriate scenarios, with a final result generated. The primary purpose of the automatic mode is conducting express-calculations when detailed information about emergency is unavailable. In the interactive mode selection and start-up of a chain of calculation modules, setting parameters for used models, their correction and other actions key for the system operations are performed by a system user (expert). There are no differences between the automatic and interactive modes in terms of storage of calculation results in the system and method of data transmission between the modules within the chain. The telecommunication subsystem (TCS) is designed to provide linkage between programs occurring an different computers and connected both in the local network and the telecommunication system EGASKRO and, possibly, commercial

On the DAMA and CoGeNT Modulations

DEFF Research Database (Denmark)

Frandsen, Mads Toudal; Kahlhoefer, Felix; March-Russell, John

2011-01-01

DAMA observes an annual modulation in their event rate, as might be expected from dark matter scatterings, while CoGeNT has reported evidence for a similar modulation. The simplest interpretation of these findings in terms of dark matter-nucleus scatterings is excluded by other direct detection...... constraints, while inelasticity enhances the annual modulation fraction of the signal, bringing the CoGeNT and CDMS results into better agreement....

Temperature Profile of IR Blocking Windows Used in Cryogenic X-Ray Spectrometers

International Nuclear Information System (INIS)

Friedrich, S.; Funk, T.; Drury, O.; Labov, S.E.

2000-01-01

Cryogenic high-resolution X-ray spectrometers are typically operated with thin IR blocking windows to reduce radiative heating of the detector while allowing good x-ray transmission. We have estimated the temperature profile of these IR blocking windows under typical operating conditions. We show that the temperature in the center of the window is raised due to radiation from the higher temperature stages. This can increase the infrared photon flux onto the detector, thereby increasing the IR noise and decreasing the cryostat hold time. The increased window temperature constrains the maximum window size and the number of windows required. We discuss the consequences for IR blocking window design

Learning from Clostridium novyi-NT: How to defeat cancer

Directory of Open Access Journals (Sweden)

Li Wang

2018-01-01

Full Text Available Side effects associated with conventional anticancer therapies have prompted the new idea of solid tumor treatment strategy. One of them is using bacteria explored as potential antitumor agents over more than one century. Notably, the ideal therapy is a specifical target to tumors with limited toxicity. Here, we take “Clostridium novyi” for the search keyword in the PubMed from 2000 to 2015 and describe that C. novyi-NT spores act as “Trojan horse” for bacteriolytic therapy. This therapy is based on the fact that the live and attenuated obligate anaerobic bacteria are capable of binary fission selectively in anoxic areas of solid tumors and direct tumoricidal effects. Our succinct review mainly concentrates on the potential mechanisms of combination bacteriolytic therapy, an effective and safe tumor therapy with the help of C. novyi-NT. Importantly, C. novyi-NT spores were shown to induce solid tumor regression and exhibit the property to initiate an immune response. Therefore, C. novyi-NT spores should be an effective and safe tumor therapy.

Permeability of the blood-brain barrier to the neurotensin8-13 analog NT1.

Science.gov (United States)

Banks, W A; Wustrow, D J; Cody, W L; Davis, M D; Kastin, A J

1995-10-09

Neurotensin (NT) has been suggested to be a neuropeptide with therapeutic potential. We used multiple-time regression analysis to measure the unidirectional influx constant (Ki) of a tritiated analog of NT8-13, NT1, with improved metabolic stability. The Ki of [3H]NT1 across the blood-brain barrier (BBB) was 5.12(10(-4)) ml/g-min and was decreased 66% by unlabeled NT1 system. The amount of NT1 crossing the BBB, 0.087% of the injected dose per gram of brain, is consistent with its exerting central effects after peripheral administration. The stable [3H]NT1 crossed the BBB in intact form as assessed by HPLC and completely crossed the endothelial cells that comprise the BBB as assessed by the capillary depletion method. The presence of a transport system could be important for the development of NT analogs.

The H-mode operational window as determined from the ITER H-mode database

International Nuclear Information System (INIS)

Ryter, F.; Kardaun, O.J.W.F.; Stroth, U.

1994-01-01

The H-mode is a promising regime for fusion reactors and it is essential to be able to predict its operational window in future devices. The 'H-Mode Database Working Group' started in 1992 to gather, analyze and compare H-mode threshold data from several divertor tokamaks so that predictions could be made. The database and first results were presented and the threshold database has been improved and extended since. The work has two objectives: 1) to predict the minimum heating power necessary to reach the H-mode in future devices, 2) to contribute to physics studies of the L-H transition. (author) 11 refs., 2 figs

Replacement Windows for Existing Homes Homes | Efficient Windows

Science.gov (United States)

Collaborative Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring

Design Guidance for New Windows | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Selection Process for New Windows | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Selection Process for Replacement Windows | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Design Guidance for Replacement Windows | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Proper Installation of New Windows | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

The N-terminal neurotensin fragment, NT1-11, inhibits cortisol secretion by human adrenocortical cells.

Science.gov (United States)

Sicard, Flavie; Contesse, Vincent; Lefebvre, Hervé; Ait-Ali, Djida; Gras, Marjorie; Cartier, Dorthe; Decker, Annick; Chartrel, Nicolas; Anouar, Youssef; Vaudry, Hubert; Delarue, Catherine

2006-08-01

Neurotensin (NT) modulates corticosteroid secretion from the mammalian adrenal gland. The objective of this study was to investigate the possible involvement of NT in the control of cortisol secretion in the human adrenal gland. In vitro studies were conducted on cultured human adrenocortical cells. This study was conducted in a university research laboratory. Adrenal explants from patients undergoing expanded nephrectomy for kidney cancer were studied. Cortisol secretion from cultured adrenocortical cells was measured. NT1-11, the N-terminal fragment of NT, dose-dependently inhibited basal and ACTH-stimulated cortisol production by human adrenocortical cells in primary culture. In contrast, NT had no influence on cortisol output at concentrations up to 10(-6) m. HPLC and RT-PCR analyses failed to detect any significant amounts of NT and NT mRNA, respectively, in adrenal extracts. Molecular and pharmacological studies were performed to determine the type of NT receptor involved in the corticostatic effect of NT1-11. RT-PCR analysis revealed the expression of NT receptor type (NTR) 3 mRNA but not NTR1 and NTR2 mRNAs in the human adrenal tissue. However, the pharmacological profile of the adrenal NT1-11 receptor was different from that of NTR3, indicating that this receptor type is not involved in the action of NT1-11 on corticosteroidogenesis. Our results indicate that NT1-11 may act as an endocrine factor to inhibit cortisol secretion through activation of a receptor distinct from the classical NTR1, NTR2, and NTR3.

Design of large aperture, low mass vacuum windows

International Nuclear Information System (INIS)

Mapes, M.; Leonhardt, W.J.

1993-01-01

Large aperture, low mass, thin vacuum windows are required to minimize beam loss in the beam lines of particle accelerators as the products of nuclear collisions move from upstream targets to downstream detectors. This article describes the design, fabrication, testing, and operating experience of a large rectangular vacuum window, 122 cmx61 cm, and two circular windows of 91.4 and 96.5 cm diam. These window designs utilize a composite Kevlar 29 fabric and Mylar laminate as a window material with a typical combined thickness of 0.35 mm. Data for several material thicknesses are also presented. The windows are usually designed to withstand a pressure differential of two to three atmospheres to achieve the required factor of safety. These windows are typically used in the medium vacuum range of 10 -4 Torr. The equations used to predict the behavior of the window material will also be discussed

Windows 7 Annoyances Tips, Secrets, and Solutions

CERN Document Server

Karp, David

2010-01-01

Windows 7 may be faster and more stable than Vista, but it's a far cry from problem-free. David A. Karp comes to the rescue with the latest in his popular Windows Annoyances series. This thorough guide gives you the tools you need to fix the troublesome parts of this operating system, plus the solutions, hacks, and timesaving tips to make the most of your PC. Streamline Windows Explorer, improve the Search tool, eliminate the Green Ribbon of Death, and tame User Account Control promptsExplore powerful Registry tips and tools, and use them to customize every aspect of Windows and solve its sho

Strength and Fatigue of NT551 Silicon Nitride and NT551 Diesel Exhaust Valves

Energy Technology Data Exchange (ETDEWEB)

Andrews, M.J.; Wereszczak, A.A.; Kirkland, T.P.; Breder, K.

2000-02-01

The content of this report is excerpted from Mark Andrew's Ph.D. Thesis (Andrews, 1999), which was funded by a DOEYOTT High Temperature Materials Laboratory Graduate Fellowship. It involves the characterization of NT551 and valves fabricated with it. Greater detail of the described issues may be found in that reference or through communications with Andrew Wereszczak.

Low mass large aperture vacuum window development at CEBAF

International Nuclear Information System (INIS)

Keppel, C.

1995-01-01

Large aperture low mass vacuum windows are being developed for the HMS (High Momentum Spectrometer) and SOS (Short Orbit Spectrometer) spectrometers in Hall C at CEBAF. Because multiple scattering degrades the performance of a spectrometer it is important that the volume be evacuated and that the entrance and exit windows be as low mass as possible. The material used for such windows must be thin and light enough so as to have minimum effect of the beam, and at the same time, be thick and strong enough to operate reliably and safely. To achieve these goals, composite vacuum windows have been constructed of a thin sheet of Mylar with a reinforcing fabric. Reinforcing fabrics such as Kevlar and Spectra are available with tensile strengths significantly greater than that of Mylar. A thin layer of Myler remains necessary since the fabrics cannot achieve any sort of vacuum seal. The design, fabrication, testing, and operating experience with such composite windows for the Hall C spectrometers will be discussed

Optimising window parameters for energy efficiency

Energy Technology Data Exchange (ETDEWEB)

Boland, J. [South Australia Univ., Adelaide, SA (Australia); Luther, M. [Deakin Univ., Geelong, VIC (Australia)

1996-12-31

Large north facing windows act a solar collectors, with the heat being stored in the building mass and being released later in the day. This study examines one of the elements of this paradigm, that increasing the size of equatorially facing windows necessarily improves the energy efficiency of a dwelling. This question and that of whether there is a case for using double glazing in Australia were examined for a number of locations ranging from cool temperate to warm temperate and for several types of construction from lightweight to heavyweight. Simulations were performed using the modelling tool Cheetah. It was found that the optimal window size on equatorially facing walls was smaller than expected for singly glazed windows. Double glazing was found to be effective in most situations and increased the optimum size of the window substantially. Changing the operational pattern of the house (specifically when cooling equipment may be employed) considerably affects conclusions about single and double glazing. (author). 3 tabs., 3 figs., 13 refs.

Radiation-transparent windows, method for imaging fluid transfers

Science.gov (United States)

Shu, Deming [Darien, IL; Wang, Jin [Burr Ridge, IL

2011-07-26

A thin, x-ray-transparent window system for environmental chambers involving pneumatic pressures above 40 bar is presented. The window allows for x-ray access to such phenomena as fuel sprays injected into a pressurized chamber that mimics realistic internal combustion engine cylinder operating conditions.

Design of large aperture, low mass vacuum windows

International Nuclear Information System (INIS)

Leonhardt, W.J.; Mapes, M.

1993-01-01

Large vacuum vessels are employed downstream of fixed targets in High Energy Physics experiments to provide a long path for particles to traverse without interacting with air molecules. These vessels generally have a large aperture opening known as a vacuum window which employs a thin membrane to preserve the vacuum environment yet allows the particles to pass through with a minimal effect on them. Several large windows have been built using a composite of Kevlar/Mylar including circular windows to a diameter of 96.5 cm and rectangular windows up to 193 cm x 86 cm. This paper describes the design, fabrication, testing and operating experience with these windows and relates the actual performance to theoretical predictions

Windows

DEFF Research Database (Denmark)

Heiselberg, Per; Svidt, Kjeld; Nielsen, Peter V.

In natural ventilation systems fresh air is often provided through opening of windows. However, the knowledge of the performance of windows is rather limited. Computation of natural ventilation air flow through windows is most commonly made using discharge coefficients, that are regarded as being...... constant. The reported results show that the discharge coefficient for a window opening cannot be regarded as a constant and that it varies considerably with the size of the opening area, the window type and the temperature difference. Therefore, the use of a constant value can lead to serious errors...

Measure Guideline: Window Repair, Rehabilitation, and Replacement

Energy Technology Data Exchange (ETDEWEB)

Baker, P.

2012-12-01

This measure guideline provides information and guidance on rehabilitating, retrofitting, and replacing existing window assemblies in residential construction. The intent is to provide information regarding means and methods to improve the energy and comfort performance of existing wood window assemblies in a way that takes into consideration component durability, in-service operation, and long term performance of the strategies.

T25 ITER ECH window development 110 GHz ECH distributed window development. Final report, May 1, 1994 - December 31, 1995

International Nuclear Information System (INIS)

Olstad, R.A.; Moeller, C.P.; Grunloh, H.J.

1998-01-01

Electron Cyclotron Heating (ECH) is one of the major candidates for Heating and Current Drive on ITER. ECH is extremely attractive from a reactor engineering point of view, offering compact launch structures, high injected power density, and a simple interface with the shield/blanket. Economic deployment of ECH for ITER requires MW unit microwave sources (gyrotrons). The present technology limitation is the availability of suitable low loss output windows. These are needed for the torus as well as the tube. The torus window, in particular, is a demanding application as it also serves as a tritium barrier. Several distinct window concepts are under development by the various Parties. This report summarizes the efforts to make and test a open-quotes distributedclose quotes window suitable for 1 MW cw operation at 110 GHz. A companion report (Final Report on Task 245+) describes the efforts to make a distributed window suitable for 1 MW cw operation at 170 GHz, the main frequency of interest to ITER. General Atomics (GA) fabricated a 4 in. x 4 in. 110 GHz distributed window which was delivered in September 1995 to Communications and Power Industries (CPI). Hot tests at CPI confirmed the power handling capability of the window. Tests were conducted with a reduced beam size at 200 kW with 0.7 s pulses without any arcing or excessive window temperatures. The power density and pulse length were equivalent to that in a full size 1.2 MW CW beam with a peak-to-average power ratio of 2.7. This window was assembled using a gold braze material to bond the sapphire strips to the niobium frame. The braze was successful except for small leaks at two locations, and re-braze efforts were unsuccessful

Determination of finite-difference weights using scaled binomial windows

KAUST Repository

Chu, Chunlei; Stoffa, Paul L.

2012-01-01

The finite-difference method evaluates a derivative through a weighted summation of function values from neighboring grid nodes. Conventional finite-difference weights can be calculated either from Taylor series expansions or by Lagrange interpolation polynomials. The finite-difference method can be interpreted as a truncated convolutional counterpart of the pseudospectral method in the space domain. For this reason, we also can derive finite-difference operators by truncating the convolution series of the pseudospectral method. Various truncation windows can be employed for this purpose and they result in finite-difference operators with different dispersion properties. We found that there exists two families of scaled binomial windows that can be used to derive conventional finite-difference operators analytically. With a minor change, these scaled binomial windows can also be used to derive optimized finite-difference operators with enhanced dispersion properties. © 2012 Society of Exploration Geophysicists.

Determination of finite-difference weights using scaled binomial windows

KAUST Repository

Chu, Chunlei

2012-05-01

The finite-difference method evaluates a derivative through a weighted summation of function values from neighboring grid nodes. Conventional finite-difference weights can be calculated either from Taylor series expansions or by Lagrange interpolation polynomials. The finite-difference method can be interpreted as a truncated convolutional counterpart of the pseudospectral method in the space domain. For this reason, we also can derive finite-difference operators by truncating the convolution series of the pseudospectral method. Various truncation windows can be employed for this purpose and they result in finite-difference operators with different dispersion properties. We found that there exists two families of scaled binomial windows that can be used to derive conventional finite-difference operators analytically. With a minor change, these scaled binomial windows can also be used to derive optimized finite-difference operators with enhanced dispersion properties. © 2012 Society of Exploration Geophysicists.

Transcriptional coactivator NT-PGC-1α promotes gluconeogenic gene expression and enhances hepatic gluconeogenesis.

Science.gov (United States)

Chang, Ji Suk; Jun, Hee-Jin; Park, Minsung

2016-10-01

The transcriptional coactivator PGC-1α plays a central role in hepatic gluconeogenesis. We previously reported that alternative splicing of the PGC-1α gene produces an additional transcript encoding the truncated protein NT-PGC-1α NT-PGC-1α is co-expressed with PGC-1α and highly induced by fasting in the liver. NT-PGC-1α regulates tissue-specific metabolism, but its role in the liver has not been investigated. Thus, the objective of this study was to determine the role of hepatic NT-PGC-1α in the regulation of gluconeogenesis. Adenovirus-mediated expression of NT-PGC-1α in primary hepatocytes strongly stimulated the expression of key gluconeogenic enzyme genes (PEPCK and G6Pase), leading to increased glucose production. To further understand NT-PGC-1α function in hepatic gluconeogenesis in vivo, we took advantage of a previously reported FL-PGC-1α -/- mouse line that lacks full-length PGC-1α (FL-PGC-1α) but retains a slightly shorter and functionally equivalent form of NT-PGC-1α (NT-PGC-1α 254 ). In FL-PGC-1α -/- mice, NT-PGC-1α 254 was induced by fasting in the liver and recruited to the promoters of PEPCK and G6Pase genes. The enrichment of NT-PGC-1α 254 at the promoters was closely associated with fasting-induced increase in PEPCK and G6Pase gene expression and efficient production of glucose from pyruvate during a pyruvate tolerance test in FL-PGC-1α -/- mice. Moreover, FL-PGC-1α -/- primary hepatocytes showed a significant increase in gluconeogenic gene expression and glucose production after treatment with dexamethasone and forskolin, suggesting that NT-PGC-1α 254 is sufficient to stimulate the gluconeogenic program in the absence of FL-PGC-1α Collectively, our findings highlight the role of hepatic NT-PGC-1α in stimulating gluconeogenic gene expression and glucose production. © 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

Distinct functional characteristics of levocabastine sensitive rat neurotensin NT2 receptor expressed in Chinese hamster ovary cells.

Science.gov (United States)

Yamada, M; Yamada, M; Lombet, A; Forgez, P; Rostène, W

1998-01-01

Neurotensin has been shown to produce pharmacological effects both in brain and periphery. Several of these effects are mediated by a high-affinity neurotensin NT1 receptor. On the other hand, a low-affinity levocabastine-sensitive neurotensin NT2 receptor was molecularly cloned from rodent brain recently. In this study, in contrast to NT1 receptor, levocabastine (a histamine H1 receptor antagonist) and SR48692 (an antagonist for NT1 receptor) strongly stimulated intracellular Ca2+ mobilization in transfected Chinese hamster ovary cells expressing rat NT2 receptor, thus acting as potent NT2 receptor. Furthermore, despite of their affinities for NT2 receptor, the Ca2+ responses to potent NT1 agonists, neurotensin or JMV449 ([Lys8-(CH2NH)-Lys9]Pro-Tyr-Ile-Leu, a peptidase resistant analogue of neurotensin) were much smaller than that observed with SR48692. These findings suggest that NT1 and NT2 receptors present distinct functional characteristics and that SR48692 may act as a potent agonist for NT2 receptor.

Microsoft Windows 7: A survey of its awareness and the likely ...

African Journals Online (AJOL)

... hardware incompatibility, especially among medium and small organizations. This will result in the upsurge of new system procurements in the next five years. Keywords: Microsoft, windows 7, computers, windows XP, windows vista, operating systems. International Journal of Natural and Applied Sciences, 6(2): 136-143, ...

NT-proBNP, Cardiometabolic Risk Factors, and Nutritional Status in Hemodialysis Patients

Directory of Open Access Journals (Sweden)

Jacques Ducros

2017-01-01

Full Text Available Background. We aimed to evaluate the association between NT-proBNP and malnutrition in HD patients while taking into account the four established categories of parameters for diagnosis of protein energy wasting (PEW. Methods. A cross-sectional study was performed in Afro-Caribbean dialysis patients. One component in each of the 4 categories for the wasting syndrome was retained: serum albumin ≤ 38 g/L, BMI ≤ 23 Kg/m2, serum creatinine ≤ 818 µmol/L, and normalized protein catabolic rate (nPCR ≤ 0.8 g/kg/day. NT-proBNP was assessed using a chemiluminescence immunoassay. Two multivariate logistic regression models were performed to determine the parameters associated with high NT-proBNP concentrations. Results. In 207 HD patients, 16.9% had PEW (at least three components. LVEF lower than 60% was found in 13.8% of patients. NT-proBNP levels ranged from 125 to 33144 pg/mL. In model 1, high levels of NT-proBNP (≥6243 pg/mL were independently associated with PEW OR 14.2 (3.25–62.4, male gender 2.80 (1.22–6.57, hsCRP > 5 mg/L 3.90 (1.77–8.57, and dialysis vintage > 3 years 3.84 (1.35–10.8. In model 2, LVEF OR was 0.93 (0.88–0.98. NT-proBNP concentrations were significantly higher when the PEW component number was higher. Conclusion. In dialysis patients, high NT-proBNP levels must draw attention to cardiac function but also to nutritional status.

Web interfaces to relational databases

Science.gov (United States)

Carlisle, W. H.

1996-01-01

This reports on a project to extend the capabilities of a Virtual Research Center (VRC) for NASA's Advanced Concepts Office. The work was performed as part of NASA's 1995 Summer Faculty Fellowship program and involved the development of a prototype component of the VRC - a database system that provides data creation and access services within a room of the VRC. In support of VRC development, NASA has assembled a laboratory containing the variety of equipment expected to be used by scientists within the VRC. This laboratory consists of the major hardware platforms, SUN, Intel, and Motorola processors and their most common operating systems UNIX, Windows NT, Windows for Workgroups, and Macintosh. The SPARC 20 runs SUN Solaris 2.4, an Intel Pentium runs Windows NT and is installed on a different network from the other machines in the laboratory, a Pentium PC runs Windows for Workgroups, two Intel 386 machines run Windows 3.1, and finally, a PowerMacintosh and a Macintosh IIsi run MacOS.

A Virtual Astronomical Research Machine in No Time (VARMiNT)

Science.gov (United States)

Beaver, John

2012-05-01

We present early results of using virtual machine software to help make astronomical research computing accessible to a wider range of individuals. Our Virtual Astronomical Research Machine in No Time (VARMiNT) is an Ubuntu Linux virtual machine with free, open-source software already installed and configured (and in many cases documented). The purpose of VARMiNT is to provide a ready-to-go astronomical research computing environment that can be freely shared between researchers, or between amateur and professional, teacher and student, etc., and to circumvent the often-difficult task of configuring a suitable computing environment from scratch. Thus we hope that VARMiNT will make it easier for individuals to engage in research computing even if they have no ready access to the facilities of a research institution. We describe our current version of VARMiNT and some of the ways it is being used at the University of Wisconsin - Fox Valley, a two-year teaching campus of the University of Wisconsin System, as a means to enhance student independent study research projects and to facilitate collaborations with researchers at other locations. We also outline some future plans and prospects.

Scaling proprioceptor gene transcription by retrograde NT3 signaling.

Directory of Open Access Journals (Sweden)

Jun Lee

Full Text Available Cell-type specific intrinsic programs instruct neuronal subpopulations before target-derived factors influence later neuronal maturation. Retrograde neurotrophin signaling controls neuronal survival and maturation of dorsal root ganglion (DRG sensory neurons, but how these potent signaling pathways intersect with transcriptional programs established at earlier developmental stages remains poorly understood. Here we determine the consequences of genetic alternation of NT3 signaling on genome-wide transcription programs in proprioceptors, an important sensory neuron subpopulation involved in motor reflex behavior. We find that the expression of many proprioceptor-enriched genes is dramatically altered by genetic NT3 elimination, independent of survival-related activities. Combinatorial analysis of gene expression profiles with proprioceptors isolated from mice expressing surplus muscular NT3 identifies an anticorrelated gene set with transcriptional levels scaled in opposite directions. Voluntary running experiments in adult mice further demonstrate the maintenance of transcriptional adjustability of genes expressed by DRG neurons, pointing to life-long gene expression plasticity in sensory neurons.

Operation and control software for APNEA

Energy Technology Data Exchange (ETDEWEB)

McClelland, J.H.; Storm, B.H. Jr.; Ahearn, J. [Lockheed-Martin Specialty Components, Largo, FL (United States)] [and others

1997-11-01

The human interface software for the Lockheed Martin Specialty Components (LMSC) Active/Passive Neutron Examination & Analysis System (APENA) provides a user friendly operating environment for the movement and analysis of waste drums. It is written in Microsoft Visual C++ on a Windows NT platform. Object oriented and multitasking techniques are used extensively to maximize the capability of the system. A waste drum is placed on a loading platform with a fork lift and then automatically moved into the APNEA chamber in preparation for analysis. A series of measurements is performed, controlled by menu commands to hardware components attached as peripheral devices, in order to create data files for analysis. The analysis routines use the files to identify the pertinent radioactive characteristics of the drum, including the type, location, and quantity of fissionable material. At the completion of the measurement process, the drum is automatically unloaded and the data are archived in preparation for storage as part of the drum`s data signature. 3 figs.

Operation and control software for APNEA

International Nuclear Information System (INIS)

McClelland, J.H.; Storm, B.H. Jr.; Ahearn, J.

1997-01-01

The human interface software for the Lockheed Martin Specialty Components (LMSC) Active/Passive Neutron Examination ampersand Analysis System (APENA) provides a user friendly operating environment for the movement and analysis of waste drums. It is written in Microsoft Visual C++ on a Windows NT platform. Object oriented and multitasking techniques are used extensively to maximize the capability of the system. A waste drum is placed on a loading platform with a fork lift and then automatically moved into the APNEA chamber in preparation for analysis. A series of measurements is performed, controlled by menu commands to hardware components attached as peripheral devices, in order to create data files for analysis. The analysis routines use the files to identify the pertinent radioactive characteristics of the drum, including the type, location, and quantity of fissionable material. At the completion of the measurement process, the drum is automatically unloaded and the data are archived in preparation for storage as part of the drum's data signature. 3 figs

Probing dark matter streams with CoGeNT

International Nuclear Information System (INIS)

Natarajan, Aravind; Savage, Christopher; Freese, Katherine

2011-01-01

We examine the future sensitivity of CoGeNT to the presence of dark matter streams and find that consideration of streams in the data may lead to differences in the interpretation of the results. We show the allowed particle mass and cross section for different halo parameters, assuming spin-independent elastic scattering. As an example, we choose a stream with the same velocity profile as that of the Sagittarius stream (and in the Solar neighborhood) and find that, with an exposure of ∼10 kg yr, the CoGeNT results can be expected to exclude the standard-halo-model-only halo in favor of a standard halo model+stream halo at the 95% (99.7%) confidence level, provided the stream contributes 3% (5%) of the local dark matter density. The presence of a significant stream component may result in incorrect estimates of the particle mass and cross section unless the presence of the stream is taken into account. We conclude that the CoGeNT experiment is sensitive to streams and care should be taken to include the possibility of streams when analyzing experimental results.

ORF Alignment: NT_033778 [GENIUS II[Archive

Lifescience Database Archive (English)

Full Text Available de-binding protein [Periplaneta americana] ... pir||JQ0708 lipopolysaccharide-binding protein precurs... NT_033778 gi|24762680 >1qddA 8 141 113 253 1e-15 ... dbj|BAA00616.1| lipopolysacchari

Mixed-mode Operating System for Real-time Performance

Directory of Open Access Journals (Sweden)

M.M. Hasan

2017-11-01

Full Text Available The purpose of the mixed-mode system research is to handle devices with the accuracy of real-time systems and at the same time, having all the benefits and facilities of a matured Graphic User Interface (GUI operating system which is typically nonreal-time. This mixed-mode operating system comprising of a real-time portion and a non-real-time portion was studied and implemented to identify the feasibilities and performances in practical applications (in the context of scheduled the real-time events. In this research an i8751 microcontroller-based hardware was used to measure the performance of the system in real-time-only as well as non-real-time-only configurations. The real-time portion is an 486DX-40 IBM PC system running under DOS-based realtime kernel and the non-real-time portion is a Pentium III based system running under Windows NT. It was found that mixed-mode systems performed as good as a typical realtime system and in fact, gave many additional benefits such as simplified/modular programming and load tolerance.

Reliability of the Nidek NT-1000 non contact tonometer.

Science.gov (United States)

Van de Velde, T; Zeyen, T

1995-01-01

In this prospective study, we compared the intraocular pressure (IOP) readings of 100 patients measured with the Goldmann applanation tonometer and the Nidek NT-1000 pneumotonometer. The correlation coefficient between the Goldmann and Nidek readings was 0.86. On the average the pneumotonometer overestimated the intraocular pressure with 0.43 mm Hg. The Nidek NT-1000 non contact tonometer can be used for screening purposes provided an appropriately low IOP value is used to indicate the need for further assessment with the Goldman applanation tonometer.

Measure Guideline. Wood Window Repair, Rehabilitation, and Replacement

Energy Technology Data Exchange (ETDEWEB)

Baker, P. [Building Science Corporation, Somerville, MA (United States); Eng, P. [Building Science Corporation, Somerville, MA (United States)

2012-12-01

This measure guideline provides information and guidance on rehabilitating, retrofitting, and replacing existing window assemblies in residential construction. The intent is to provide information regarding means and methods to improve the energy and comfort performance of existing wood window assemblies in a way that takes into consideration component durability, in-service operation, and long term performance of the strategies.

ORF Alignment: NT_033779 [GENIUS II[Archive

Lifescience Database Archive (English)

Full Text Available n-like protein CL3 [Periplaneta americana] ... Length = 128 ... Query: 1 ... MVLDNQEDKLLTTTFLKSMGLSFTQSWHH... NT_033779 gi|21357645 >1qddA 26 143 127 254 1e-07 ... dbj|BAA82266.1| Cockroach lecti

SAGE FOR WINDOWS (WSAGE) VERSION 1.0 SOLVENT ALTERNATIVES GUIDE - USER'S GUIDE

Science.gov (United States)

The guide provides instructions for using the Solvent Alternatives Guide (SAGE) for Windows, version 1.0. The guide assumes that the user is familiar with the fundamentals of operating Windows 3.1 (or higher) on a personal computer under the DOS 5.0 (or higher) operating system. ...

Microsoft Windows Server Administration Essentials

CERN Document Server

Carpenter, Tom

2011-01-01

The core concepts and technologies you need to administer a Windows Server OS Administering a Windows operating system (OS) can be a difficult topic to grasp, particularly if you are new to the field of IT. This full-color resource serves as an approachable introduction to understanding how to install a server, the various roles of a server, and how server performance and maintenance impacts a network. With a special focus placed on the new Microsoft Technology Associate (MTA) certificate, the straightforward, easy-to-understand tone is ideal for anyone new to computer administration looking t

Windows Vista Administrator's Pocket Guide

CERN Document Server

Stanek, William R

2007-01-01

Portable and precise, this pocket-sized guide delivers immediate answers for the day-to-day administration of Windows Vista. Zero in on core support and maintenance tasks using quick-reference tables, instructions, and lists. You'll get the precise information you need to solve problems and get the job done-whether you're at your desk or in the field! Get fast facts to: Install and configure Windows Vista-and optimize the user workspaceMaintain operating system components, hardware devices, and driversCreate user and group accounts-and control rights and permissionsAdminister group policy se

Large Acrylic Spherical Windows In Hyperbaric Underwater Photography

Science.gov (United States)

Lones, Joe J.; Stachiw, Jerry D.

1983-10-01

Both acrylic plastic and glass are common materials for hyperbaric optical windows. Although glass continues to be used occasionally for small windows, virtually all large viewports are made of acrylic. It is easy to uderstand the wide use of acrylic when comparing design properties of this plastic with those of glass, and glass windows are relatively more difficult to fabricate and use. in addition there are published guides for the design and fabrication of acrylic windows to be used in the hyperbaric environment of hydrospace. Although these procedures for fabricating the acrylic windows are somewhat involved, the results are extremely reliable. Acrylic viewports are now fabricated to very large sizes for manned observation or optical quality instrumen tation as illustrated by the numerous acrylic submersible vehicle hulls for hu, an occupancy currently in operation and a 3600 large optical window recently developed for the Walt Disney Circle Vision under-water camera housing.

The research of optical windows used in aircraft sensor systems

International Nuclear Information System (INIS)

Zhou Feng; Li Yan; Tang Tian-Jin

2012-01-01

The optical windows used in aircrafts protect their imaging sensors from environmental effects. Considering the imaging performance, flat surfaces are traditionally used in the design of optical windows. For aircrafts operating at high speeds, the optical windows should be relatively aerodynamic, but a flat optical window may introduce unacceptably high drag to the airframes. The linear scanning infrared sensors used in aircrafts with, respectively, a flat window, a spherical window and a toric window in front of the aircraft sensors are designed and compared. Simulation results show that the optical design using a toric surface has the integrated advantages of field of regard, aerodynamic drag, narcissus effect, and imaging performance, so the optical window with a toric surface is demonstrated to be suited for this application. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

Sincronización de Células de Tabaco (Nicotiana tabacum) NT-1

OpenAIRE

Ruiz, León F; Higareda, Ana E; Pardo, Marco A

2010-01-01

Se ha evaluado la capacidad sincronizante de afidicolina e hidroxiurea en cultivos de células de tabaco (Nicotiana tabacum) NT-1. Los cultivos sincronizados son poderosas herramientas en estudios moleculares y bioquímicos relacionados al ciclo celular y comúnmente se utilizan químicos para bloquear el ciclo celular. La línea celular de tabaco (Nicotiana tabacum) NT-1 proviene de la línea celular TBY-2, caracterizándose NT-1 por su menor velocidad de crecimiento y tamaño celular heterogéneo. L...

Higher level of NT-proCNP in cerebrospinal fluid of patients with meningitis.

Science.gov (United States)

Tomasiuk, Ryszard; Lipowski, Dariusz; Szlufik, Stanislaw; Peplinska, Krystyna; Mikaszewska-Sokolewicz, Malgorzata

2016-02-12

Aminoterminal pro-C type natriuretic peptide (NT-proCNP) as an active form of CNP, has been recently proven to be a potential marker of sepsis and to be linked to inflammatory diseases. So far, there are no studies describing the level of NT-proCNP in meningitis. The purpose of this study was to evaluate the diagnostic value of NT-proCNP in cerebrospinal fluid (CSF) in patients with meningitis and to compare it with the serum level of CRP and procalcitonin (PCT) in this group of patients. The results were compared to serum levels of CRP, PCT and CSF levels of cytosis, protein and lactate. NT-proCNP levels were statistically significant between the control group and the meningitis groups (p=0.02; R=0.3). We also noted a correlation between the level of NT-proCNP in the CSF of all of the study groups (controls and meningitis patients) and the CSF levels of cytosis (p0.05; R=0.11). These results suggest that NT-proCNP could be a potential marker of meningitis, but it cannot be used to distinguish between the types of meningitis. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Windows Azure

CERN Document Server

Johnson, Bruce; Chambers, James; Garber, Danny; Malik, Jamal; Fazio, Adam

2013-01-01

A collection of five must-have Azure titles, from some of the biggest names in the field Available individually, but at a discounted rate for the collection, this bundle of five e-books covers key developer and IT topics of Windows Azure, including ASP.NET, mobile services, web sites, data storage, and the hybrid cloud. A host of Microsoft employees and MPVs come together to cover the biggest challenges that professionals face when working with Windows Azure. The e-books included are as follows: Windows Azure and ASP.NET MVC MigrationWindows Azure Mobile ServicesWindows Azure Web SitesWindows

Learning Windows Azure Mobile Services for Windows 8 and Windows Phone 8

CERN Document Server

Webber-Cross, Geoff

2014-01-01

This book is based around a case study game which was written for the book. This means that the chapters progress in a logical way and build upon lessons learned as we go. Real-world examples are provided for each topic that are practical and not given out-of-context so they can be applied directly to other applications.If you are a developer who wishes to build Windows 8 and Phone 8 applications and integrate them with Windows Azure Mobile Services, this book is for you. Basic C# and JavaScript skills are advantageous, as well as some knowledge of building Windows 8 or Windows Phone 8 applica

Windows Vista Kernel-Mode: Functions, Security Enhancements and Flaws

Directory of Open Access Journals (Sweden)

Mohammed D. ABDULMALIK

2008-06-01

Full Text Available Microsoft has made substantial enhancements to the kernel of the Microsoft Windows Vista operating system. Kernel improvements are significant because the kernel provides low-level operating system functions, including thread scheduling, interrupt and exception dispatching, multiprocessor synchronization, and a set of routines and basic objects.This paper describes some of the kernel security enhancements for 64-bit edition of Windows Vista. We also point out some weakness areas (flaws that can be attacked by malicious leading to compromising the kernel.

Regulation of Brown and White Adipocyte Transcriptome by the Transcriptional Coactivator NT-PGC-1α.

Directory of Open Access Journals (Sweden)

Jihyun Kim

Full Text Available The β3-adrenergic receptor (AR signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation. The β3-AR signaling highly induces the expression of transcriptional coactivator PGC-1α and its splice variant N-terminal (NT-PGC-1α, which in turn activate the transcription program of adaptive thermogenesis by co-activating a number of transcription factors. We previously reported that NT-PGC-1α is able to increase mitochondrial number and activity in cultured brown adipocytes by promoting the expression of mitochondrial and thermogenic genes. In the present study, we performed genome-wide profiling of NT-PGC-1α-responsive genes in brown adipocytes to identify genes potentially regulated by NT-PGC-1α. Canonical pathway analysis revealed that a number of genes upregulated by NT-PGC-1α are highly enriched in mitochondrial pathways including fatty acid transport and β-oxidation, TCA cycle and electron transport system, thus reinforcing the crucial role of NT-PGC-1α in the enhancement of mitochondrial function. Moreover, canonical pathway analysis of NT-PGC-1α-responsive genes identified several metabolic pathways including glycolysis and fatty acid synthesis. In order to validate the identified genes in vivo, we utilized the FL-PGC-1α-/- mouse that is deficient in full-length PGC-1α (FL-PGC-1α but expresses a slightly shorter and functionally equivalent form of NT-PGC-1α (NT-PGC-1α254. The β3-AR-induced increase of NT-PGC-1α254 in FL-PGC-1α-/- brown and white adipose tissue was closely associated with elevated expression of genes involved in thermogenesis, mitochondrial oxidative metabolism, glycolysis and fatty acid synthesis. Increased adipose tissue thermogenesis by β3-AR activation resulted in attenuation of adipose tissue expansion in FL-PGC-1α-/- adipose tissue under the high-fat diet condition. Together, the data strengthen our previous findings that NT-PGC-1�

SHUFFLE. Windows 95/98/2000 version

International Nuclear Information System (INIS)

Slavic, S.; Zefran, B.

2000-01-01

Program package SHUFFLE was developed to help the user during fuel loading and unloading operations at a nuclear power plant. The first version, developed in 1992, has been written in the CLIPPER program language and run under the DOS operating system. Since the DOS environment exhibits several drawbacks regarding code portability and flexibility, the recent SHUFFLE version has been transformed to run under the MS Windows operating system. (author)

NT-proBNP on Cobas h 232 in point-of-care testing

DEFF Research Database (Denmark)

Gils, Charlotte; Ramanathan, R.; Breindahl, T.

2015-01-01

Background. NT-proBNP may be useful for ruling out heart failure in primary health care. In this study we examined the analytical quality of NT-proBNP in primary health care on the Cobas h 232 point-of-care instrument compared with measurements performed in a hospital laboratory. Materials...... and methods. Blood samples requested for NT-proBNP were collected in primary health care (n = 95) and in a hospital laboratory (n = 107). NT-proBNP was measured on-site on Cobas h 232 instruments both in primary health care centres and at the hospital laboratory and all samples were also analyzed...... with a comparison method at the hospital. Precision, trueness, accuracy, and lot-variation were determined at different concentration levels and evaluated according to acceptance criteria. Furthermore user-friendliness was assessed by questionnaires. Results. For Cobas h 232 repeatability CV was 8...

ORF Alignment: NT_033777 [GENIUS II[Archive

Lifescience Database Archive (English)

Full Text Available NT_033777 gi|24648160 >1mc2A 1 134 1 122 2e-29 ... gb|AAB20876.1| ammodytin L=myotoxi...c phospholipase A2 homologue [Vipera ... ammodytes=European viper, Peptide, 123 aa] ... Length

An Evaluation of Windows-Based Computer Forensics Application Software Running on a Macintosh

Directory of Open Access Journals (Sweden)

Gregory H. Carlton

2008-09-01

Full Text Available The two most common computer forensics applications perform exclusively on Microsoft Windows Operating Systems, yet contemporary computer forensics examinations frequently encounter one or more of the three most common operating system environments, namely Windows, OS-X, or some form of UNIX or Linux. Additionally, government and private computer forensics laboratories frequently encounter budget constraints that limit their access to computer hardware. Currently, Macintosh computer systems are marketed with the ability to accommodate these three common operating system environments, including Windows XP in native and virtual environments. We performed a series of experiments to measure the functionality and performance of the two most commonly used Windows-based computer forensics applications on a Macintosh running Windows XP in native mode and in two virtual environments relative to a similarly configured Dell personal computer. The research results are directly beneficial to practitioners, and the process illustrates affective pedagogy whereby students were engaged in applied research.

Design of large aperture, low mass vacuum windows

International Nuclear Information System (INIS)

Leonhardt, W.J.; Mapes, M.

1993-01-01

Large vacuum vessels are employed downstream of fixed targets in High Energy Physics experiments to provide a long path for particles to transverse without interacting with air molecules. These vessels generally have a large aperture opening known as a open-quotes vacuum windowclose quotes which employs a thin membrane to preserve the vacuum environment yet allows the particles to pass through with a minimal effect on them. Several large windows have been built using a composite of Kevlar/Mylar including circular windows to a diameter of 96.5 cm and rectangular windows up to 193 cm x 86 cm. This paper describes the design, fabrication, testing and operating experience with these windows and relates the actual performance to theoretical predictions

Introduction of an NT-proBNP assay to an acute admission unit--a 2-year audit.

LENUS (Irish Health Repository)

Murtagh, Gillian

2012-02-01

BACKGROUND: The differential diagnosis of dyspnoea is difficult due to the low predictive value of clinical and laboratory parameters. The elevated levels of NT-proBNP in congestive heart failure may improve diagnostic accuracy. We have evaluated the effect of the introduction of an NT-proBNP assay on hospital length of stay (LOS) and mortality. METHODS: There were 11,853 AMAU patient episodes in the 22 months study period (March 2005-Dec 2006). An NT-proBNP assay was requested in 657 (5.5%) of these. Comparison between categorical variables such as diagnosis, NT-proBNP testing, LOS, and in-hospital mortality was made using Chi-square tests. Literature review suggested that an NT-proBNP cut-off >or=5000 ng\\/L should predict acute in-patient mortality. Logistic regression analysis was used to examine the association between such an elevated NT-proBNP level and outcomes. RESULTS: Of the 396 patients with NT-proBNP <5000 ng\\/L, 8.1% died compared with 22.5% of the 178 patients dying with values >or=5000 ng\\/L (p<0.0001). An NT-proBNP >or=5000 ng\\/L was predictive of both LOS >or=9 days (odds ratios (OR) 1.54 (95% CI 1.06, 2.24: p=0.02) and LOS >or=14 days (OR=1.87 (95% CI 1.29, 2.71: p=0.0009). NT-proBNP requests increased over time, from 2.6% to 8.2% of all patients; the result fell in the diagnostic range for CHF in 60% of requests. CONCLUSION: The introduction of an NT-proBNP was reflected in an appropriate but rapidly increasing pattern of requests from clinicians. High NT-proBNP levels predicted in-hospital mortality and longer LOS in an acute medical population.

Differential effects of BDNF and neurotrophin 4 (NT4) on endocytic sorting of TrkB receptors.

Science.gov (United States)

Proenca, Catia C; Song, Minseok; Lee, Francis S

2016-08-01

Neurotrophins are a family of growth factors playing key roles in the survival, development, and function of neurons. The neurotrophins brain-derived neurotrophic factor (BDNF) and NT4 both bind to and activate TrkB receptors, however, they mediate distinct neuronal functions. The molecular mechanism of how TrkB activation by BDNF and NT4 leads to diverse outcomes is unknown. Here, we report that BDNF and NT4 lead to differential endocytic sorting of TrkB receptors resulting in diverse biological functions in cultured cortical neurons. Fluorescent microscopy and surface biotinylation experiments showed that both neurotrophins stimulate internalization of TrkB with similar kinetics. Exposure to BDNF for 2-3 h reduced the surface pool of TrkB receptors to half, whereas a longer treatment (4-5 h) with NT4 was necessary to achieve a similar level of down-regulation. Although BDNF and NT4 induced TrkB phosphorylation with similar intensities, BDNF induced more rapid ubiquitination and degradation of TrkB than NT4. Interestingly, TrkB receptor ubiquitination by these ligands have substantially different pH sensitivities, resulting in varying degrees of receptor ubiquitination at lower pH levels. Consequently, NT4 was capable of maintaining longer sustained downstream signaling activation that correlated with reduced TrkB ubiquitination at endosomal pH. Thus, by leading to altered endocytic trafficking itineraries for TrkB receptors, BDNF and NT4 elicit differential TrkB signaling in terms of duration, intensity, and specificity, which may contribute to their functional differences in vivo. The neurotrophins, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4), both bind to and activate TrkB receptors, however, they mediate distinct neuronal functions. Here, we propose that BDNF and NT4 lead to differential endocytic sorting of TrkB receptors resulting in diverse biological functions. BDNF induces more rapid ubiquitination and degradation of TrkB than NT4

Predictive value of NT-proBNP for 30-day mortality in patients with non-ST-elevation acute coronary syndromes: a comparison with the GRACE and TIMI risk scores.

Science.gov (United States)

Schellings, Dirk Aam; Adiyaman, Ahmet; Dambrink, Jan-Henk E; Gosselink, At Marcel; Kedhi, Elvin; Roolvink, Vincent; Ottervanger, Jan Paul; Van't Hof, Arnoud Wj

2016-01-01

The biomarker N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts outcome in patients with non-ST-elevation acute coronary syndromes (NSTE-ACS). Whether NT-proBNP has incremental prognostic value beyond established risk strategies is still questionable. To evaluate the predictive value of NT-proBNP for 30-day mortality over and beyond the Global Registry of Acute Coronary Events (GRACE) and Thrombolysis In Myocardial Infarction (TIMI) risk scores in patients with NSTE-ACS. Patients included in our ACS registry were candidates. NT-proBNP levels on admission were measured and the GRACE and TIMI risk scores were assessed. We compared the predictive value of NT-proBNP to both risk scores and evaluated whether NT-proBNP improves prognostication by using receiver operator curves and measures of discrimination improvement. A total of 1324 patients were included and 50 patients died during follow-up. On logistic regression analysis NT-proBNP and the GRACE risk score (but not the TIMI risk score) both independently predicted mortality at 30 days. The predictive value of NT-proBNP did not differ significantly compared to the GRACE risk score (area under the curve [AUC]) 0.85 vs 0.87 p =0.67) but was considerably higher in comparison to the TIMI risk score (AUC 0.60 p risk score by adding NT-proBNP did not improve prognostication: AUC 0.86 ( p =0.57), integrated discrimination improvement 0.04 ( p =0.003), net reclassification improvement 0.12 ( p =0.21). In patients with NSTE-ACS, NT-proBNP and the GRACE risk score (but not the TIMI risk score) both have good and comparable predictive value for 30-day mortality. However, incremental prognostic value of NT-proBNP beyond the GRACE risk score could not be demonstrated.

Windows server cookbook for Windows server 2003 and Windows 2000

CERN Document Server

Allen, Robbie

2005-01-01

This practical reference guide offers hundreds of useful tasks for managing Windows 2000 and Windows Server 2003, Microsoft's latest server. These concise, on-the-job solutions to common problems are certain to save you many hours of time searching through Microsoft documentation. Topics include files, event logs, security, DHCP, DNS, backup/restore, and more

Fpga As A Part Of Ms Windows Control Environment

Directory of Open Access Journals (Sweden)

Krzysztof Kołek

2007-01-01

Full Text Available The attention is focused on the Windows operating system (OS used as a control and measurementenvironment. Windows OS due to extensions becomes a real-time OS (RTOS.Benefits and drawbacks of typical software extensions are compared. As far as hardwaresolutions are concerned the field programmable gate arrays FPGA technology is proposed toensure fast time-critical operations. FPGA-based parallel execution and hardware implementationof the data processing algorithms significantly outperform the classical microprocessoroperating modes. Suitability of the RTOS for a particular application and FPGA hardwaremaintenance is studied.

Real-time operating system timing jitter and its impact on motor control

Science.gov (United States)

Proctor, Frederick M.; Shackleford, William P.

2001-12-01

General-purpose microprocessors are increasingly being used for control applications due to their widespread availability and software support for non-control functions like networking and operator interfaces. Two classes of real-time operating systems (RTOS) exist for these systems. The traditional RTOS serves as the sole operating system, and provides all OS services. Examples include ETS, LynxOS, QNX, Windows CE and VxWorks. RTOS extensions add real-time scheduling capabilities to non-real-time OSes, and provide minimal services needed for the time-critical portions of an application. Examples include RTAI and RTL for Linux, and HyperKernel, OnTime and RTX for Windows NT. Timing jitter is an issue in these systems, due to hardware effects such as bus locking, caches and pipelines, and software effects from mutual exclusion resource locks, non-preemtible critical sections, disabled interrupts, and multiple code paths in the scheduler. Jitter is typically on the order of a microsecond to a few tens of microseconds for hard real-time operating systems, and ranges from milliseconds to seconds in the worst case for soft real-time operating systems. The question of its significance on the performance of a controller arises. Naturally, the smaller the scheduling period required for a control task, the more significant is the impact of timing jitter. Aside from this intuitive relationship is the greater significance of timing on open-loop control, such as for stepper motors, than for closed-loop control, such as for servo motors. Techniques for measuring timing jitter are discussed, and comparisons between various platforms are presented. Techniques to reduce jitter or mitigate its effects are presented. The impact of jitter on stepper motor control is analyzed.

The application of DEA (Data Envelopment Analysis) window analysis in the assessment of influence on operational efficiencies after the establishment of branched hospitals.

Science.gov (United States)

Jia, Tongying; Yuan, Huiyun

2017-04-12

Many large-scaled public hospitals have established branched hospitals in China. This study is to provide evidence for strategy making on the management and development of multi-branched hospitals by evaluating and comparing the operational efficiencies of different hospitals before and after their establishment of branched hospitals. DEA (Data Envelopment Analysis) window analysis was performed on a 7-year data pool from five public hospitals provided by health authorities and institutional surveys. The operational efficiencies of sample hospitals measured in this study (including technical efficiency, pure technical efficiency and scale efficiency) had overall trends towards increase during this 7-year period of time, however, a temporary downturn occurred shortly after the establishment of branched hospitals; pure technical efficiency contributed more to the improvement of technical efficiency compared to scale efficiency. The establishment of branched-hospitals did not lead to a long-term negative effect on hospital operational efficiencies. Our data indicated the importance of improving scale efficiency via the optimization of organizational management, as well as the advantage of a different form of branch-establishment, merging and reorganization. This study brought an insight into the practical application of DEA window analysis on the assessment of hospital operational efficiencies.

Purine Restriction Induces Pronounced Translational Upregulation of the NT1 Adenosine/Pyrimidine Nucleoside Transporter in Leishmania major

OpenAIRE

Ortiz, Diana; Valdés, Raquel; Sanchez, Marco A.; Hayenga, Johanna; Elya, Carolyn; Detke, Siegfried; Landfear, Scott M.

2010-01-01

Leishmania and other parasitic protozoa are unable to synthesize purines de novo and are reliant upon purine nucleoside and nucleobase transporters to import preformed purines from their hosts. To study the roles of the four purine permeases NT1-NT4 in Leishmania major, null mutants in each transporter gene were prepared and the effect of each gene deletion on purine uptake was monitored. Deletion of the NT3 purine nucleobase transporter gene or both NT3 and the NT2 nucleoside transporter gen...

MS Windows domēna darbstaciju migrācija no MS Windows XP uz Windows Vista.

OpenAIRE

Tetere, Agate

2009-01-01

Kvalifikācijas darbā izpētīju darbstaciju migrācijas no Windows XP uz Windows Vista plusus un mīnusus. Darba gaitā tika veikti sekojoši uzdevumi: 1.Veikta Windows XP un Windows Vista darbstaciju instalācija, iestatījumu konfigurēšana un tika pārbaudīta sistēmas darbība 2.Veikta Windows Server 2003 un Windows Server 2008 instalācija, iestatījumu konfigurēšana un tika pārbaudīta sistēmas darbība 3.Izstrādāts migrācijas modelis 4.Veikta migrācijas optimizēšana 5.Veikta datu migrāc...

Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells.

Science.gov (United States)

Vita, N; Oury-Donat, F; Chalon, P; Guillemot, M; Kaghad, M; Bachy, A; Thurneyssen, O; Garcia, S; Poinot-Chazel, C; Casellas, P; Keane, P; Le Fur, G; Maffrand, J P; Soubrie, P; Caput, D; Ferrara, P

1998-11-06

The human levocabastine-sensitive neurotensin NT2 receptor was cloned from a cortex cDNA library and stably expressed in Chinese hamster ovary (CHO) cells in order to study its binding and signalling characteristics. The receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. It also binds levocabastine, a histamine H1 receptor antagonist that is not recognised by neurotensin NT1 receptor. Neurotensin binding to recombinant neurotensin NT2 receptor expressed in CHO cells does not elicit a biological response as determined by second messenger measurements. Levocabastine, and the peptides neuromedin N and xenin were also ineffective on neurotensin NT2 receptor activation. Experiments with the neurotensin NT1 receptor antagonists SR48692 and SR142948A, resulted in the unanticipated discovery that both molecules are potent agonists on neurotensin NT2 receptor. Both compounds, following binding to neurotensin NT2 receptor, enhance inositol phosphates (IP) formation with a subsequent [Ca2+]i mobilisation; induce arachidonic acid release; and stimulate mitogen-activated protein kinase (MAPK) activity. Interestingly, these activities are antagonised by neurotensin and levocabastine in a concentration-dependent manner. These activities suggest that the human neurotensin NT2 receptor may be of physiological importance and that a natural agonist for the receptor may exist.

Purine restriction induces pronounced translational upregulation of the NT1 adenosine/pyrimidine nucleoside transporter in Leishmania major.

Science.gov (United States)

Ortiz, Diana; Valdés, Raquel; Sanchez, Marco A; Hayenga, Johanna; Elya, Carolyn; Detke, Siegfried; Landfear, Scott M

2010-10-01

Leishmania and other parasitic protozoa are unable to synthesize purines de novo and are reliant upon purine nucleoside and nucleobase transporters to import preformed purines from their hosts. To study the roles of the four purine permeases NT1-NT4 in Leishmania major, null mutants in each transporter gene were prepared and the effect of each gene deletion on purine uptake was monitored. Deletion of the NT3 purine nucleobase transporter gene or both NT3 and the NT2 nucleoside transporter gene resulted in pronounced upregulation of adenosine and uridine uptake mediated by the NT1 permease and also induced up to a 200-fold enhancement in the level of the NT1 protein but not mRNA. A similar level of upregulation of NT1 was achieved in wild-type promastigotes that were transferred to medium deficient in purines. Pulse labelling and treatment of cells with the translation inhibitor cycloheximide revealed that control of NT1 expression occurs primarily at the level of translation and not protein turnover. These observations imply the existence of a translational control mechanism that enhances the ability of Leishmania parasites to import essential purines when they are present at limiting concentrations. © 2010 Blackwell Publishing Ltd.

The Fifteenth International Conference on the Science and Application of Nanotubes (NT14)

Energy Technology Data Exchange (ETDEWEB)

cronin, stephen

2015-01-06

The Fifteenth International Conference on the Science and Application of Nanotubes (NT14) was held at the University of Southern California in Los Angeles, California on June 2-6, 2014. NT14 upheld the NT tradition of presenting the latest results in the science and applications of nanotubes and related materials in plenary sessions. Emphasis was given to convivial poster sessions and student participation. Over 225 participants attended the conference, including students, post-docs, faculty, and members from industry. A total of 45 talks were presented, as well as 157 posters.

Design of the beryllium window for Brookhaven Linac Isotope Producer

International Nuclear Information System (INIS)

Nayak, S.; Mapes, M.; Raparia, D.

2015-01-01

In the Brookhaven Linac Isotope Producer (BLIP) beam line, there were two Beryllium (Be) windows with an air gap to separate the high vacuum upstream side from low vacuum downstream side. There had been frequent window failures in the past which affected the machine productivity and increased the radiation dose received by workers due to unplanned maintenance. To improve the window life, design of Be window is reexamined. Detailed structural and thermal simulations are carried out on Be window for different design parameters and loading conditions to come up with better design to improve the window life. The new design removed the air gap and connect the both beam lines with a Be window in-between. The new design has multiple advantages such as 1) reduces the beam energy loss (because of one window with no air gap), 2) reduces air activation due to nuclear radiation and 3) increased the machine reliability as there is no direct pressure load during operation. For quick replacement of this window, an aluminum bellow coupled with load binder was designed. There hasn't been a single window failure since the new design was implemented in 2012.

Níveis NT-Pro-BNP e resposta ao exercício em pacientes com fluxo lento coronariano NT-Pro-BNP levels and their response to exercise in patients with slow coronary flow

Directory of Open Access Journals (Sweden)

Mustafa Yurtdaş

2012-12-01

Full Text Available FUNDAMENTO: Os peptídeos natriuréticos são liberados pelo coração em resposta ao estresse da parede. OBJETIVO: As concentrações de NT-Pro-BNP em pacientes com Fluxo Lento Coronariano (FLC foram avaliadas antes e depois do teste de exercício e comparados com os valores dos controles saudáveis. MÉTODOS: A população do estudo foi de 34 pacientes com FLC [22 homens (64,7%, com idade 51,0 ± 6,2 anos], e 34 indivíduos normais com artérias coronarianas normais [21 homens (61,8%, com idade 53,2 ± 6,6 anos]. As taxas de fluxo coronariano dos pacientes e controles foram determinadas pelo escore TIMI Trombólise no Infarto do Miocárdio (Thrombolysis in Myocardial Infarction. As amostras de sangue foram coletadas em repouso e após o teste ergométrico. RESULTADOS: As concentrações basais de NT-Pro-BNP nos pacientes com FLC foram superiores às dos indivíduos-controle (NT-Pro-BNP: 49,7 ± 14,2 pg/mL vs. 25,3 ± 4,6 pg/mL p BACKGROUND: Natriuretic peptides are released by the heart in response to wall stress. OBJECTIVE: The NT-Pro-BNP concentrations in slow coronary flow (SCF patients were assessed before and after the exercise test and compared with the values of healthy controls. METHODS: The study population was 34 patients with SCF [22 males (64.7%, aged 51.0±6.2 years], and 34 normal subjects with normal coronary arteries [21 males (61.8%, aged 53.2±6.6 years]. Coronary flow rates of all patients and control subjects were documented as Thrombolysis in Myocardial Infarction (TIMI frame count. Blood samples were drawn at rest and after the exercise testing. RESULTS: The baseline NT-Pro-BNP concentrations of the SCF patients were higher than those of the control subjects (NT-Pro-BNP: 49.7±14.2 pg/mL vs. 25.3±4.6 pg/mL p<0.0001, respectively, and this difference increased after exercise test between the groups (NT-Pro-BNP: 69.5±18.6 pg/mL vs. 30.9±6.4 pg/mL p<0.0001. In SCF group after exercise, NT-Pro-BNP concentration in 15

Níveis NT-Pro-BNP e resposta ao exercício em pacientes com fluxo lento coronariano NT-Pro-BNP levels and their response to exercise in patients with slow coronary flow

Directory of Open Access Journals (Sweden)

Mustafa Yurtdaş

2012-01-01

Full Text Available FUNDAMENTO: Os peptídeos natriuréticos são liberados pelo coração em resposta ao estresse da parede. OBJETIVO: As concentrações de NT-Pro-BNP em pacientes com Fluxo Lento Coronariano (FLC foram avaliadas antes e depois do teste de exercício e comparados com os valores dos controles saudáveis. MÉTODOS: A população do estudo foi de 34 pacientes com FLC [22 homens (64,7%, com idade 51,0 ± 6,2 anos], e 34 indivíduos normais com artérias coronarianas normais [21 homens (61,8%, com idade 53,2 ± 6,6 anos]. As taxas de fluxo coronariano dos pacientes e controles foram determinadas pelo escore TIMI Trombólise no Infarto do Miocárdio (Thrombolysis in Myocardial Infarction. As amostras de sangue foram coletadas em repouso e após o teste ergométrico. RESULTADOS: As concentrações basais de NT-Pro-BNP nos pacientes com FLC foram superiores às dos indivíduos-controle (NT-Pro-BNP: 49,7 ± 14,2 pg/mL vs. 25,3 ± 4,6 pg/mL p BACKGROUND: Natriuretic peptides are released by the heart in response to wall stress. OBJECTIVE: The NT-Pro-BNP concentrations in slow coronary flow (SCF patients were assessed before and after the exercise test and compared with the values of healthy controls. METHODS: The study population was 34 patients with SCF [22 males (64.7%, aged 51.0±6.2 years], and 34 normal subjects with normal coronary arteries [21 males (61.8%, aged 53.2±6.6 years]. Coronary flow rates of all patients and control subjects were documented as Thrombolysis in Myocardial Infarction (TIMI frame count. Blood samples were drawn at rest and after the exercise testing. RESULTS: The baseline NT-Pro-BNP concentrations of the SCF patients were higher than those of the control subjects (NT-Pro-BNP: 49.7±14.2 pg/mL vs. 25.3±4.6 pg/mL p<0.0001, respectively, and this difference increased after exercise test between the groups (NT-Pro-BNP: 69.5±18.6 pg/mL vs. 30.9±6.4 pg/mL p<0.0001. In SCF group after exercise, NT-Pro-BNP concentration in 15

Windows 8: What Educators Need to Know

Science.gov (United States)

Vedder, Richard G.

2012-01-01

In October 2012, Microsoft will release the commercial version of its next operating system, presently called "Windows 8." This version represents a significant departure from the past. Microsoft wants this operating system to meet user needs regardless of physical platform (e.g., desktop, notebook, tablet, mobile phone). As part of this mission,…

Effect of PCI on inflammatory factors, cTnI, MMP-9 and NT-pro BNP in patients with unstable angina pectoris

Directory of Open Access Journals (Sweden)

Ke-Tong Liu

2016-05-01

Full Text Available Objective: To investigate the effect of PCI on inflammatory factors, cTnI, MMP-9and NTpro BNP in patients with unstable angina pectoris. Methods: A total of 80 unstable angina pectoris patients were divided into observation group (40 cases and control group (40 cases. The observation group was given the therapy of PCI, and the control group was given coronary angiography. To observe the of inflammatory factors, cTnI, MMP-9 and NT-pro BNP were tested and compared before and after operation. Results: At 24 h after operation, CRP and IL-18 levels were increased significantly after treatment inoperation groups, there was no difference on inflammatory factors in control group, and had significant difference on inflammatory factors in two groups; At 24 h after operation, cTnI, MMP-9 and NT-pro BNP levels were increased significantly after treatment inoperation groups, there was no difference on inflammatory factors in control group, and had significant difference on inflammatory factors in two groups. Conclusion: PCI therapy can induce inflammation and myocardial injury in patients with unstable angina pectoris.

Ultra-Sensitive NT-proBNP Quantification for Early Detection of Risk Factors Leading to Heart Failure

Directory of Open Access Journals (Sweden)

Keum-Soo Song

2017-09-01

Full Text Available Cardiovascular diseases such as acute myocardial infarction and heart failure accounted for the death of 17.5 million people (31% of all global deaths in 2015. Monitoring the level of circulating N-terminal proBNP (NT-proBNP is crucial for the detection of people at risk of heart failure. In this article, we describe a novel ultra-sensitive NT-proBNP test (us-NT-proBNP that allows the quantification of circulating NT-proBNP in 30 min at 25 °C in the linear detection range of 7.0–600 pg/mL. It is a first report on the application of a fluorescence bead labeled detection antibody, DNA-guided detection method, and glass fiber membrane platform for the quantification of NT-proBNP in clinical samples. Limit of blank, limit of detection, and limit of quantification were 2.0 pg/mL, 3.7 pg/mL, and 7 pg/mL, respectively. The coefficient of variation was found to be less than 10% in the entire detection range of 7–600 pg/mL. The test demonstrated specificity for NT-proBNP without interferences from bilirubin, intra-lipid, biotin, and hemoglobin. The serial dilution test for plasma samples containing various NT-proBNP levels showed the linear decrement in concentration with the regression coefficient of 0.980–0.998. These results indicate that us-NT-proBNP test does not suffer from the interference of the plasma components for the measurement of NT-proBNP in clinical samples.

Migration towards Windows 2000/XP

International Nuclear Information System (INIS)

Gal, J.

2004-01-01

The article deals with interesting technical solutions used in the project 'Migration towards Windows 2000/XP', which was introduced by the company AITEN, Plc for companies SE Plc, SEPS Plc and TEKO, Plc in the period 2002 and 2003. The contents of the project was migration of about 100 servers and more than 4 000 PC to the Windows 2000 and XP environs. The result of the project is a unified and documented system in the field of file, print and small application servers and PC. It has enabled to increase the system reliability and availability, to decrease the total costs for administration and operation and to establish the steady environs for users of the applications. (author)

X-Window for process control in a mixed hardware environment

International Nuclear Information System (INIS)

Clausen, M.; Rehlich, K.

1992-01-01

X-Window is a common standard for display purposes on the current workstations. The possibility to create more than one window on a single screen enables the operators to gain more information about the process. Multiple windows from different control systems using mixed hardware is one of the problems this paper will describe. The experience shows that X-Window is a standard per definition, but not in any case. But it is an excellent tool to separate data-acquisition and display from each other over long distances using different types of hardware and software for communications and display. Our experience with X-Window displays for the cryogenic control system and the vacuum control system at HERA on DEC and SUN hardware will be described. (author)

Involvement of the putative Ca²⁺-permeable mechanosensitive channels, NtMCA1 and NtMCA2, in Ca²⁺ uptake, Ca²⁺-dependent cell proliferation and mechanical stress-induced gene expression in tobacco (Nicotiana tabacum) BY-2 cells.

Science.gov (United States)

Kurusu, Takamitsu; Yamanaka, Takuya; Nakano, Masataka; Takiguchi, Akiko; Ogasawara, Yoko; Hayashi, Teruyuki; Iida, Kazuko; Hanamata, Shigeru; Shinozaki, Kazuo; Iida, Hidetoshi; Kuchitsu, Kazuyuki

2012-07-01

To gain insight into the cellular functions of the mid1-complementing activity (MCA) family proteins, encoding putative Ca²⁺-permeable mechanosensitive channels, we isolated two MCA homologs of tobacco (Nicotiana tabacum) BY-2 cells, named NtMCA1 and NtMCA2. NtMCA1 and NtMCA2 partially complemented the lethality and Ca²⁺ uptake defects of yeast mutants lacking mechanosensitive Ca²⁺ channel components. Furthermore, in yeast cells overexpressing NtMCA1 and NtMCA2, the hypo-osmotic shock-induced Ca²⁺ influx was enhanced. Overexpression of NtMCA1 or NtMCA2 in BY-2 cells enhanced Ca²⁺ uptake, and significantly alleviated growth inhibition under Ca²⁺ limitation. NtMCA1-overexpressing BY-2 cells showed higher sensitivity to hypo-osmotic shock than control cells, and induced the expression of the touch-inducible gene, NtERF4. We found that both NtMCA1-GFP and NtMCA2-GFP were localized at the plasma membrane and its interface with the cell wall, Hechtian strands, and at the cell plate and perinuclear vesicles of dividing cells. NtMCA2 transcript levels fluctuated during the cell cycle and were highest at the G1 phase. These results suggest that NtMCA1 and NtMCA2 play roles in Ca²⁺-dependent cell proliferation and mechanical stress-induced gene expression in BY-2 cells, by regulating the Ca²⁺ influx through the plasma membrane.

Waveguide transition with vacuum window for multiband dynamic nuclear polarization systems

Energy Technology Data Exchange (ETDEWEB)

Rybalko, Oleksandr; Bowen, Sean; Zhurbenko, Vitaliy [Technical University of Denmark, Ørsteds Plads 349, 2800 Kgs. Lyngby (Denmark); Ardenkjær-Larsen, Jan Henrik, E-mail: jhar@elektro.dtu.dk [Technical University of Denmark, Ørsteds Plads 349, 2800 Kgs. Lyngby (Denmark); GE Healthcare, Park Alle 295, Brøndby (Denmark)

2016-05-15

A low loss waveguide transition section and oversized microwave vacuum window covering several frequency bands (94 GHz, 140 GHz, 188 GHz) is presented. The transition is compact and was optimized for multiband Dynamic Nuclear Polarization (DNP) systems in a full-wave simulator. The window is more broadband than commercially available windows, which are usually optimized for single band operation. It is demonstrated that high-density polyethylene with urethane adhesive can be used as a low loss microwave vacuum window in multiband DNP systems. The overall assembly performance and dimensions are found using full-wave simulations. The practical aspects of the window implementation in the waveguide are discussed. To verify the design and simulation results, the window is tested experimentally at the three frequencies of interest.

Prognostic threshold levels of NT-proBNP testing in primary care

DEFF Research Database (Denmark)

Rosenberg, J.; Schou, M.; Gustafsson, F.

2008-01-01

AIMS: Chronic heart failure (HF) is a common condition with a poor prognosis. As delayed diagnosis and treatment of HF patients in primary care can be detrimental, risk-stratified waiting lists for echocardiography might optimize resource utilization. We investigated whether a prognostic threshold...... level of the cardiac peptide, NT-proBNP, could be identified. METHODS AND RESULTS: From 2003-2005, 5875 primary care patients with suspected HF (median age 73 years) had NT-proBNP analysed in the Copenhagen area. Eighteen percent died and 20% had a cardiovascular (CV) hospitalization (median follow....../mL) was associated with an 80% (95% CI: 20-190, P = 0.01) increased mortality risk after adjustment for age, sex, previous hospitalization, CV diseases, and chronic diseases. CONCLUSION: We identified prognostic threshold levels for mortality and CV hospitalization for NT-proBNP in primary care patients suspected...

The quantum state vector in phase space and Gabor's windowed Fourier transform

International Nuclear Information System (INIS)

Bracken, A J; Watson, P

2010-01-01

Representations of quantum state vectors by complex phase space amplitudes, complementing the description of the density operator by the Wigner function, have been defined by applying the Weyl-Wigner transform to dyadic operators, linear in the state vector and anti-linear in a fixed 'window state vector'. Here aspects of this construction are explored, and a connection is established with Gabor's 'windowed Fourier transform'. The amplitudes that arise for simple quantum states from various choices of windows are presented as illustrations. Generalized Bargmann representations of the state vector appear as special cases, associated with Gaussian windows. For every choice of window, amplitudes lie in a corresponding linear subspace of square-integrable functions on phase space. A generalized Born interpretation of amplitudes is described, with both the Wigner function and a generalized Husimi function appearing as quantities linear in an amplitude and anti-linear in its complex conjugate. Schroedinger's time-dependent and time-independent equations are represented on phase space amplitudes, and their solutions described in simple cases.

The impact of the MCU life extension solvent on sludge batch 8 projected operating windows

International Nuclear Information System (INIS)

Peeler, D.K.; Edwards, T.B.

2013-01-01

As a part of the Actinide Removal Process (ARP)/Modular Caustic Side Solvent Extraction Unit (MCU) Life Extension Project, a next generation solvent (NGS) and a new strip acid will be deployed. The strip acid will be changed from dilute nitric acid to dilute boric acid (0.01 M). Because of these changes, experimental testing or evaluations with the next generation solvent are required to determine the impact of these changes (if any) to Chemical Process Cell (CPC) activities, glass formulation strategies, and melter operations at the Defense Waste Processing Facility (DWPF). The introduction of the dilute (0.01 M) boric acid stream into the DWPF flowsheet has a potential impact on glass formulation and frit development efforts since B203 is a major oxide in frits developed for DWPF. Prior knowledge of this stream can be accounted for during frit development efforts but that was not the case for Sludge Batch 8 (SB8). Frit 803 has already been recommended and procured for SB8 processing; altering the frit to account for the incoming boron from the strip effluent (SE) is not an option for SB8. Therefore, the operational robustness of Frit 803 to the introduction of SE including its compositional tolerances (i.e., up to 0.0125M boric acid) is of interest and was the focus of this study. The primary question to be addressed in the current study was: What is the impact (if any) on the projected operating windows for the Frit 803 - SB8 flowsheet to additions of B203 from the SE in the Sludge Receipt and Adjustment Tank (SRAT)? More specifically, will Frit 803 be robust to the potential compositional changes occurring in the SRAT due to sludge variation, varying additions of ARP and/or the introduction of SE by providing access to waste loadings (WLs) of interest to DWPF? The Measurement Acceptability Region (MAR) results indicate there is very little, if any, impact on the projected operating windows for the Frit 803 - SB8 system regardless of the presence or absence of

Review of window and filter requirements for commissioning of the Advanced Photon Source insertion device beamlines

International Nuclear Information System (INIS)

Kuzay, T.M.; Wang, Zhibi.

1994-01-01

The Advanced Photon Source (APS) is building 16 insertion device (ID) front ends for the first phase of the project. Eleven of these are to be equipped with the APS Undulator A and the other five with a Wiggler-A-type source. The Undulator A front ends are designed to operate in a ''windowless'' mode using an APS-designed differential pump. However, during beamline commissioning and early operations of the storage ring, it is prudent to install windows to ensure storage ring vacuum safety before easing into windowless operation. However, the window designed for this interim period may not meet all the needs of a user's scientific program. In the early phases of the project through commissioning and start of operations, such a window will permit the user to prepare for his program, while allowing both the user and the facility operators to gain experience for safe phasing into eventual windowless operations. In this report, we will present analysis and design options for a variety of windows particularly suited to either the APS Undulator A front ends or as user windows located in the first optics enclosure (FOE)

Window Stories

DEFF Research Database (Denmark)

Hauge, Bettina

This research project has investigated 17 households in Germany (cities and rural areas). The main aim was to learn about the significance of the window to these people: What they think of their windows, how, when and why they use them in their everyday life, if they have a favorite window and wh...

Windows 10 simplified

CERN Document Server

McFedries, Paul

2015-01-01

Learn Windows 10 quickly and painlessly with this beginner's guide Windows 10 Simplified is your absolute beginner's guide to the ins and outs of Windows. Fully updated to cover Windows 10, this highly visual guide covers all the new features in addition to the basics, giving you a one-stop resource for complete Windows 10 mastery. Every page features step-by-step screen shots and plain-English instructions that walk you through everything you need to know, no matter how new you are to Windows. You'll master the basics as you learn how to navigate the user interface, work with files, create

Windows and doors

Energy Technology Data Exchange (ETDEWEB)

1988-01-01

A complete manual is presented on windows and doors for the housing contractor. In order to understand the role of windows and doors in a house's energy performance, an introduction explains the house as a system of components that can have effects on each other. Further chapters explain in detail the parts of a window, window types and RSI values; window servicing and repair; window replacement; parts of a door, door types and RSI values; door service and repair, including weatherstripping; door replacement; and how to ensure quality, service, and customer satisfaction. A glossary of terms is included. 61 figs., 3 tabs.

Pharmacogenetic characterization of naturally occurring germline NT5C1A variants to chemotherapeutic nucleoside analogs

Science.gov (United States)

Saliba, Jason; Zabriskie, Ryan; Ghosh, Rajarshi; Powell, Bradford C; Hicks, Stephanie; Kimmel, Marek; Meng, Qingchang; Ritter, Deborah I; Wheeler, David A; Gibbs, Richard A; Tsai, Francis T F; Plon, Sharon E

2016-01-01

Background Mutations or alteration in expression of the 5’ nucleotidase gene family can confer altered responses to treatment with nucleoside analogs. While investigating leukemia susceptibility genes, we discovered a very rare p.L254P NT5C1A missense variant in the substrate recognition motif. Given the paucity of cellular drug response data from NT5C1A germline variation, we characterized p.L254P and eight rare variants of NT5C1A from genomic databases. Methods Through lentiviral infection, we created HEK293 cell lines that stably overexpress wildtype NT5C1A, p.L254P, or eight NT5C1A variants reported in the NHLBI Exome Variant server (one truncating and seven missense). IC50 values were determined by cytotoxicity assays after exposure to chemotherapeutic nucleoside analogs (Cladribine, Gemcitabine, 5-Fluorouracil). In addition, we used structure-based homology modeling to generate a 3D model for the C-terminal region of NT5C1A. Results The p.R180X (truncating), p.A214T, and p.L254P missense changes were the only variants that significantly impaired protein function across all nucleotide analogs tested (>5-fold difference versus WT; p<.05). Several of the remaining variants individually displayed differential effects (both more and less resistant) across the analogs tested. The homology model provided a structural framework to understand the impact of NT5C1A mutants on catalysis and drug processing. The model predicted active site residues within NT5C1A motif III and we experimentally confirmed that p.K314 (not p.K320) is required for NT5C1A activity. Conclusion We characterized germline variation and predicted protein structures of NT5C1A. Individual missense changes showed substantial variation in response to the different nucleoside analogs tested, which may impact patients’ responses to treatment. PMID:26906009

San Onofre 2/3 simulator: The move from Unix to Windows

International Nuclear Information System (INIS)

Paquette, C.; Desouky, C.; Gagnon, V.

2006-01-01

CAE has been developing nuclear power plant (NPP) simulators for over 30 years for customers around the world. While numerous operating systems are used today for simulators, many of the existing simulators were developed to run on workstation-type computers using a variant of the Unix operating system. Today, thanks to the advances in the power and capabilities of Personal Computers (PC's), and because most simulators will eventually need to be upgraded, more and more of these RISC processor-based simulators will be converted to PC-based platforms running either the Windows or Linux operating systems. CAE's multi-platform simulation environment runs on the UNIX Linux and Windows operating systems, enabling simulators to be 'open' and highly interoperable systems using industry-standard software components and methods. The result is simulators that are easier to maintain and modify as reference plants evolve. In early January 2003, CAE set out to upgrade Southern California Edison's San Onofre Unit 2/3 UNIX-based simulator with its latest integrated simulation environment. This environment includes CAE's instructor station Isis, the latest ROSE modeling and runtime tool, as well as the deployment of a new reactor kinetics model (COMET) and new nuclear steam supply system (ANTHEM2000). The chosen simulation platform is PC-based and runs the Windows XP operating system. The main features and achievements of the San Onofre 2/3 Simulator's modernization from RISC/Unix to Intel/Windows XP, running CAE's current simulation environment, is the subject of this paper. (author)

Mastering Microsoft Windows Small Business Server 2008

CERN Document Server

Johnson, Steven

2010-01-01

A complete, winning approach to the number one small business solution. Do you have 75 or fewer users or devices on your small-business network? Find out how to integrate everything you need for your mini-enterprise with Microsoft's new Windows Server 2008 Small Business Server, a custom collection of server and management technologies designed to help small operations run smoothly without a giant IT department. This comprehensive guide shows you how to master all SBS components as well as handle integration with other Microsoft technologies.: Focuses on Windows Server 2008 Small Business Serv

Tobacco arabinogalactan protein NtEPc can promote banana (Musa AAA) somatic embryogenesis.

Science.gov (United States)

Shu, H; Xu, L; Li, Z; Li, J; Jin, Z; Chang, S

2014-12-01

Banana is an important tropical fruit worldwide. Parthenocarpy and female sterility made it impossible to improve banana varieties through common hybridization. Genetic transformation for banana improvement is imperative. But the low rate that banana embryogenic callus was induced made the transformation cannot be performed in many laboratories. Finding ways to promote banana somatic embryogenesis is critical for banana genetic transformation. After tobacco arabinogalactan protein gene NtEPc was transformed into Escherichia coli (DE3), the recombinant protein was purified and filter-sterilized. A series of the sterilized protein was added into tissue culture medium. It was found that the number of banana immature male flowers developing embryogenic calli increased significantly in the presence of NtEPc protein compared with the effect of the control medium. Among the treatments, explants cultured on medium containing 10 mg/l of NtEPc protein had the highest chance to develop embryogenic calli. The percentage of lines that developed embryogenic calli on this medium was about 12.5 %. These demonstrated that NtEPc protein can be used to promote banana embryogenesis. This is the first paper that reported that foreign arabinogalactan protein (AGP) could be used to improve banana somatic embryogenesis.

Upgrade of of monitoring devices for radiation information

Energy Technology Data Exchange (ETDEWEB)

Kim, Jung Taek; Park, Won Man; Kim, Jung Soo; Lee, Bong Jae; Jae Yoo Kyung

1999-01-01

The Radiation Monitoring System (RMS) in Hanaro of KAERI and NPPs of Korea, supplied by victoreen, sometimes has been stopped to use slow 486 PC (Personal computer) and not to be enough memory in main processing computer, IOCA and IOCB, for signal processing and storing. It is very difficult for operator to operate and maintain RMS, because of using an unfamiliar operating system, SCO Unix, of main computer. And also, ScanRad (TM) program for processing and storing radiation signal has Y2K problems and is able to lose and not to display measuring signals. Therefore it needs to upgrade the computer system in RMS. This study is upgrading the main computer, IOCA, in RMS of Hanaro to Pentium PC, and changing operating System to Window NT-based system. Therefore it needs to upgrade the computer system in RMS. This study is upgrading the main computer, IOCA, in RMS of Hanaro to Pentium PC, and changing Operating System to Window NT-based system. Therefore a performance of the computer system in RMS has been upgraded for operator to be useful. This study is going two steps. First, the main computer, IOCA a part of the whole computer system has been upgraded to Pentium PC, and changed to Window NT-based system. Second, all of the computer system in Hanaro RMS is going to be upgraded. This study has got the following results: a RS-232C serial communication program: between the upgraded IOCA and LCU (Local Control Unit) -- a serial communication test configurating two LCU serial --a parallel communication test configurating two LCU parallel: GUI program to present a radioactive information -- overview schematic display page -- detail display pages -- alarm and event pages -- trend pages and group trend pages.

Upgrade of of monitoring devices for radiation information

International Nuclear Information System (INIS)

Kim, Jung Taek; Park, Won Man; Kim, Jung Soo; Lee, Bong Jae; Jae Yoo Kyung

1999-01-01

The Radiation Monitoring System (RMS) in Hanaro of KAERI and NPPs of Korea, supplied by victoreen, sometimes has been stopped to use slow 486 PC (Personal computer) and not to be enough memory in main processing computer, IOCA and IOCB, for signal processing and storing. It is very difficult for operator to operate and maintain RMS, because of using an unfamiliar operating system, SCO Unix, of main computer. And also, ScanRad (TM) program for processing and storing radiation signal has Y2K problems and is able to lose and not to display measuring signals. Therefore it needs to upgrade the computer system in RMS. This study is upgrading the main computer, IOCA, in RMS of Hanaro to Pentium PC, and changing operating System to Window NT-based system. Therefore it needs to upgrade the computer system in RMS. This study is upgrading the main computer, IOCA, in RMS of Hanaro to Pentium PC, and changing Operating System to Window NT-based system. Therefore a performance of the computer system in RMS has been upgraded for operator to be useful. This study is going two steps. First, the main computer, IOCA a part of the whole computer system has been upgraded to Pentium PC, and changed to Window NT-based system. Second, all of the computer system in Hanaro RMS is going to be upgraded. This study has got the following results: a RS-232C serial communication program: between the upgraded IOCA and LCU (Local Control Unit) -- a serial communication test configurating two LCU serial --a parallel communication test configurating two LCU parallel: GUI program to present a radioactive information -- overview schematic display page -- detail display pages -- alarm and event pages -- trend pages and group trend pages

Serum NT-proCNP levels increased after initiation of GH treatment in patients with achondroplasia/hypochondroplasia.

Science.gov (United States)

Kubota, Takuo; Wang, Wei; Miura, Kohji; Nakayama, Hirofumi; Yamamoto, Keiko; Fujiwara, Makoto; Ohata, Yasuhisa; Tachibana, Makiko; Kitaoka, Taichi; Takakuwa, Satoshi; Miyoshi, Yoko; Namba, Noriyuki; Ozono, Keiichi

2016-06-01

Serum amino-terminal propeptide of C-type natriuretic peptide (NT-proCNP) levels have been proposed as a biomarker of linear growth in healthy children. The usefulness of NT-proCNP in patients with achondroplasia (ACH)/hypochondroplasia (HCH) remains to be elucidated. The objective was to study whether serum NT-proCNP level is a good biomarker for growth in ACH/HCH and other patients of short stature. This was a longitudinal cohort study. Sixteen children with ACH (aged 0·4-4·3 years), six children with HCH (2·7-6·3 years), 23 children with idiopathic short stature (ISS) (2·2-9·0 years), eight short children with GH deficiency (GHD) (2·9-6·8 years) and five short children born small for gestational age (SGA) (2·0-6·6 years). Patients with ACH/HCH received GH treatment for 1 year. Serum NT-proCNP levels and height were measured. NT-proCNP levels positively correlated with height velocity in these short children (P < 0·05, r = 0·27). NT-proCNP levels inversely correlated with age in children with ISS alone (P < 0·01, r = -0·55). Serum NT-proCNP levels in patients with ACH/HCH were increased 3 months following the initiation of GH treatment (P < 0·05). Height SDS gain during GH treatment for 1 year was positively correlated with the changes in NT-proCNP levels after the initiation of GH (P < 0·01, r = 0·72). Serum NT-proCNP levels may be a good biomarker to indicate the effect of GH treatment on growth in patients with ACH/HCH at least in the first year and height velocity in short stature patients. © 2016 John Wiley & Sons Ltd.

Thermal Analysis of the Al Window for a New CESR-c Luminosity Monitor

CERN Document Server

He, Yun; Palmer, Mark A; Rice, David

2005-01-01

A luminosity monitor using photons from radiative bhabha events at the CLEO interaction point (IP) has been installed in the Cornell Electron Storage Ring (CESR). A key vacuum and detector component is the photon window/converter whose uniformity and thickness are critical for determining the resolution of the total energy deposited in the segmented luminosity monitor. The window design must accommodate the operational requirements of the new monitor at CLEO-c beam energies of 1.5-2.5 GeV and also provide sufficient safety margin for operation at 5.3 GeV beam energies for Cornell High Energy Synchrotron Source (CHESS) running. During 5.3 GeV operation, intense stripes of synchrotron radiation from the interaction region superconducting quadrupole magnets as well as nearby bending magnets strike the window. During the course of window development, several materials and designs were evaluated. Thermal stresses were calculated using the finite element code ANSYS for various beam conditions to guide the cooling d...

NT-proBNP and diastolic left ventricular function in patients with Marfan syndrome

Directory of Open Access Journals (Sweden)

Petra Gehle

2016-09-01

Conclusions: MFS patients presenting with normal ejection fraction show disturbed diastolic function and higher NT-proBNP levels, which is partly explained by aortic Z-score. Assessment of diastolic function and NT-proBNP levels may therefore detect early abnormalities and guide surveillance and prevention management of patients with MFS.

A generalized window energy rating system for typical office buildings

Energy Technology Data Exchange (ETDEWEB)

Tian, Cheng; Chen, Tingyao; Yang, Hongxing; Chung, Tse-ming [Research Center for Building Environmental Engineering, Department of Building Services Engineering, The Hong Kong Polytechnic University, Hong Kong (China)

2010-07-15

Detailed computer simulation programs require lengthy inputs, and cannot directly provide an insight to relationship between the window energy performance and the key window design parameters. Hence, several window energy rating systems (WERS) for residential houses and small buildings have been developed in different countries. Many studies showed that utilization of daylight through elaborate design and operation of windows leads to significant energy savings in both cooling and lighting in office buildings. However, the current WERSs do not consider daylighting effect, while most of daylighting analyses do not take into account the influence of convective and infiltration heat gains. Therefore, a generalized WERS for typical office buildings has been presented, which takes all primary influence factors into account. The model includes embodied and operation energy uses and savings by a window to fully reflect interactions among the influence parameters. Reference locations selected for artificial lighting and glare control in the current common simulation practice may cause uncompromised conflicts, which could result in over- or under-estimated energy performance. Widely used computer programs, DOE2 and ADELINE, for hourly daylighting and cooling simulations have their own weaknesses, which may result in unrealistic or inaccurate results. An approach is also presented for taking the advantages of the both programs and avoiding their weaknesses. The model and approach have been applied to a typical office building of Hong Kong as an example to demonstrate how a WERS in a particular location can be established and how well the model can work. The energy effect of window properties, window-to-wall ratio (WWR), building orientation and lighting control strategies have been analyzed, and can be indicated by the localized WERS. An application example also demonstrates that the algebraic WERS derived from simulation results can be easily used for the optimal design of

76 FR 9012 - Access to Confidential Business Information by Electronic Consulting Services, Inc.

Science.gov (United States)

2011-02-16

... development for special projects; and maintain hardware and software inventory of workstations. In accordance.../maintenance of servers and operating system software (UNIX, Linux, Windows XP/2003/2000/NT); installing..., Information Management Division (7407M), Office of Pollution Prevention and Toxics, Environmental Protection...

Informatics management at IPN

International Nuclear Information System (INIS)

Givaudan, V.

1999-01-01

This group manages and coordinates hardware and software equipment for the Institute. Migration towards UNIX system is now almost complete, as equipment and data have been secured.. Windows NT Operating system is used to cooperate the different environment of the Institute. (authors)

NT-proBNP (N-Terminal pro-B-Type Natriuretic Peptide)-Guided Therapy in Acute Decompensated Heart Failure: PRIMA II Randomized Controlled Trial (Can NT-ProBNP-Guided Therapy During Hospital Admission for Acute Decompensated Heart Failure Reduce Mortality and Readmissions?).

Science.gov (United States)

Stienen, Susan; Salah, Khibar; Moons, Arno H; Bakx, Adrianus L; van Pol, Petra; Kortz, R A Mikael; Ferreira, João Pedro; Marques, Irene; Schroeder-Tanka, Jutta M; Keijer, Jan T; Bayés-Genis, Antoni; Tijssen, Jan G P; Pinto, Yigal M; Kok, Wouter E

2018-04-17

The concept of natriuretic peptide guidance has been extensively studied in patients with chronic heart failure (HF), with only limited success. The effect of NT-proBNP (N-terminal probrain natriuretic peptide)-guided therapy in patients with acute decompensated HF using a relative NT-proBNP target has not been investigated. This study aimed to assess whether NT-proBNP-guided therapy of patients with acute decompensated HF using a relative NT-proBNP target would lead to improved outcomes compared with conventional therapy. We conducted a prospective randomized controlled trial to study the impact of in-hospital guidance for acute decompensated HF treatment by a predefined NT-proBNP target (>30% reduction from admission to discharge) versus conventional treatment. Patients with acute decompensated HF with NT-proBNP levels >1700 ng/L were eligible. After achieving clinical stability, 405 patients were randomized to either NT-proBNP-guided or conventional treatment (1:1). The primary end point was dual: a composite of all-cause mortality and HF readmissions in 180 days and the number of days alive out of the hospital in 180 days. Secondary end points were all-cause mortality within 180 days, HF readmissions within 180 days, and a composite of all-cause mortality and HF readmissions within 90 days. Significantly more patients in the NT-proBNP-guided therapy group were discharged with an NT-proBNP reduction of >30% (80% versus 64%, P =0.001). Nonetheless, NT-proBNP-guided therapy did not significantly improve the combined event rate for all-cause mortality and HF readmissions (hazard ratio, 0.96; 95% confidence interval, 0.72-1.37; P =0.99) or the median number of days alive outside of the hospital (178 versus 179 days for NT-proBNP versus conventional patients, P =0.39). Guided therapy also did not significantly improve any of the secondary end points. The PRIMA II trial (Can NT-ProBNP-Guided Therapy During Hospital Admission for Acute Decompensated Heart Failure

PMCAP: A Threat Model of Process Memory Data on the Windows Operating System

Directory of Open Access Journals (Sweden)

Jiaye Pan

2017-01-01

Full Text Available Research on endpoint security involves both traditional PC platform and prevalent mobile platform, among which the analysis of software vulnerability and malware is one of the important contents. For researchers, it is necessary to carry out nonstop exploration of the insecure factors in order to better protect the endpoints. Driven by this motivation, we propose a new threat model named Process Memory Captor (PMCAP on the Windows operating system which threatens the live process volatile memory data. Compared with other threats, PMCAP aims at dynamic data in the process memory and uses a noninvasive approach for data extraction. In this paper we describe and analyze the model and then give a detailed implementation taking four popular web browsers IE, Edge, Chrome, and Firefox as examples. Finally, the model is verified through real experiments and case studies. Compared with existing technologies, PMCAP can extract valuable data at a lower cost; some techniques in the model are also suitable for memory forensics and malware analysis.

Strength and fatigue of NT551 silicon nitride and NT551 diesel exhaust valves

Energy Technology Data Exchange (ETDEWEB)

Andrews, M.J.; Werezczak, A.A.; Kirkland, T.P.; Breder, K.

2000-02-01

The content of this report is excerpted from Mark Andrew's Ph.D. Thesis (Andrews, 1999), which was funded by a DOE/OTT High Temperature Materials Laboratory Graduate Fellowship. It involves the characterization of NT551 and valves fabricated with it. The motivations behind using silicon nitride (Si{sub 3}N{sub 4}) as an exhaust valve for a diesel engine are presented in this section. There are several economic factors that have encouraged the design and implementation of ceramic components for internal combustion (IC) engines. The reasons for selecting the diesel engine valve for this are also presented.

NT-proBNP in cardiac surgery: a new tool for the management of our patients?

Science.gov (United States)

Reyes, Guillermo; Forés, Gloria; Rodríguez-Abella, R Hugo; Cuerpo, Gregorio; Vallejo, José Luis; Romero, Carlos; Pinto, Angel

2005-06-01

Our aim was to determine NT-proBNP levels in patients undergoing cardiac surgery and if those levels are related to any of the baseline clinical characteristics of patients before surgery or any of the outcomes or events after surgery. Prospective, analytic study including 83 consecutive patients undergoing cardiac surgery. Preoperatory and postoperatory data were collected. NT-proBNP levels were measured before surgery, the day of surgery, twice the following day and every 24 h until a total of nine determinations. Venous blood was obtained by direct venipuncture and collected into serum separator tubes. Samples were centrifuged within 20 min from sampling and stored for a maximum of 12 h at 2-8 degrees C before the separation of serum. Serum was stored frozen at -40 degrees C and thawed only once at the time of analysis. Mean age was 65+/-11.8 years. An Euroscore 6 was found in 30% of patients. NYHA classification was as follows: I:27.7%; II:47%; III:25.3%. Preoperative atrial fibrilation occurred in 20.5% of patients. After surgery 18.1% of patients required inotropes. Only one death was recorded. A great variability was found in preoperative NT-proBNP levels; 759.9 (S.D.:1371.1); CI 95%: 464.9 to 1054.9 pg/ml, with a wide range (6.39-8854). Median was 366.5 pg/ml. Preoperative NT-proBNP levels were unrelated to the type of surgery (CABG vs. others), sex, age and any of the cardiovascular risk factors. NT-proBNP levels were higher in high risk patients (Euroscore 6); (P=0.021), worse NYHA class (P=0.020) and patients with preoperative atrial fibrilation (m 1767 (2205) vs m 621 (1017); P=0.001). After surgery NT-proBNP levels started increasing the following day until the fourth day (P=0.03), decreasing afterwards (P=0.019). These levels were significantly higher in patients requiring inotropes after surgery (P<0.001). We did not find any relationship between NT-proBNP levels and complications rate (P=0.59). Preoperative NT-proBNP levels depend on preoperative

ORF Alignment: NT_033777 [GENIUS II[Archive

Lifescience Database Archive (English)

Full Text Available NT_033777 gi|28571958 >1bor0 1 53 282 342 4e-04 ... ref|NP_083045.3| synoviolin 1 [Mu...s musculus] gb|AAH42199.1| Synoviolin 1 [Mus ... musculus] gb|AAH80722.1| Synoviolin 1 [Mus musculus]... ... gb|AAH57917.1| Synoviolin 1 [Mus musculus] ... Length = 61 ... Query: 280 EELRQSDNICIICREDMV

Resources | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Links | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Efficient Windows Collaborative | Home

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

FAQ | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Glossary | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

OPTIMIZING TIME WINDOWS FOR MANAGING ARRIVALS OF EXPORT CONTAINERS AT CHINESE CONTAINER TERMINALS

DEFF Research Database (Denmark)

Chen, Gang; Yang, Zhongzhen

2009-01-01

of driver and truck waiting time, the cost of container cargo storage time, the truck idle cost and terminal yard fee. Secondly, to minimize the costs, a heuristic is developed based on a genetic algorithm to optimize the time window arrangement. The optimal solution involves the position and the length...... window management programme that is widely used in Chinese terminals to facilitate the terminal operations and the truck delivery operations. Firstly, the arrangement of time windows is assumed to follow the principle of minimizing the transport costs. A cost function is defined that includes the cost...

PHREEQCI; a graphical user interface for the geochemical computer program PHREEQC

Science.gov (United States)

Charlton, Scott R.; Macklin, Clifford L.; Parkhurst, David L.

1997-01-01

PhreeqcI is a Windows-based graphical user interface for the geochemical computer program PHREEQC. PhreeqcI provides the capability to generate and edit input data files, run simulations, and view text files containing simulation results, all within the framework of a single interface. PHREEQC is a multipurpose geochemical program that can perform speciation, inverse, reaction-path, and 1D advective reaction-transport modeling. Interactive access to all of the capabilities of PHREEQC is available with PhreeqcI. The interface is written in Visual Basic and will run on personal computers under the Windows(3.1), Windows95, and WindowsNT operating systems.

Agonist properties of a stable hexapeptide analog of neurotensin, N alpha MeArg-Lys-Pro-Trp-tLeu-Leu (NT1).

Science.gov (United States)

Akunne, H C; Demattos, S B; Whetzel, S Z; Wustrow, D J; Davis, D M; Wise, L D; Cody, W L; Pugsley, T A; Heffner, T G

1995-04-18

The major signal transduction pathway for neurotensin (NT) receptors is the G-protein-dependent stimulation of phospholipase C, leading to the mobilization of intracellular free Ca2+ ([Ca2+]i) and the stimulation of cyclic GMP. We investigated the functional actions of an analog of NT(8-13), N alpha MeArg-Lys-Pro-Trp-tLeu-Leu (NT1), and other NT related analogs by quantitative measurement of the cytosolic free Ca2+ concentration in HT-29 (human colonic adenocarcinoma) cells using the Ca(2+)-sensitive dye fura-2/AM and by effects on cyclic GMP levels in rat cerebellar slices. The NT receptor binding affinities for these analogs to HT-29 cell membranes and newborn (10-day-old) mouse brain membranes were also investigated. Data obtained from HT-29 cell and mouse brain membrane preparations showed saturable single high-affinity sites and binding densities (Bmax) of 130.2 and 87.5 fmol/mg protein, respectively. The respective KD values were 0.47 and 0.39 nM, and the Hill coefficients were 0.99 and 0.92. The low-affinity levocabastine-sensitive site was not present (K1 > 10,000) in either membrane preparation. Although the correlation of binding between HT-29 cell membranes and mouse brain membranes was quite significant (r = 0.92), some of the reference agents had lower binding affinities in the HT-29 cell membranes. The metabolically stable compound NT1 plus other NT analogs and related peptides [NT, NT(8-13), xenopsin, neuromedin N, NT(9-13), kinetensin and (D-Trp11)-NT] increased intracellular Ca2+ levels in HT-29 cells, indicating NT receptor agonist properties. The effect of NT1 in mobilizing [Ca2+]i blocked by SR 48692, a non-peptide NT antagonist. Receptor binding affinities of NT analogs to HT-29 cell membranes were positively correlated with potencies for mobilizing intracellular calcium in the same cells. In addition, NT1 increased cyclic GMP levels in rat cerebellar slices, confirming the latter findings of its NT agonist action. These results substantiate

Overexpression of NtPR-Q Up-Regulates Multiple Defense-Related Genes in Nicotiana tabacum and Enhances Plant Resistance to Ralstonia solanacearum

Directory of Open Access Journals (Sweden)

Yuanman Tang

2017-11-01

Full Text Available Various classes of plant pathogenesis-related proteins have been identified in the past several decades. PR-Q, a member of the PR3 family encoding chitinases, has played an important role in regulating plant resistance and preventing pathogen infection. In this paper, we functionally characterized NtPR-Q in tobacco plants and found that the overexpression of NtPR-Q in tobacco Yunyan87 resulted in higher resistance to Ralstonia solanacearum inoculation. Surprisingly, overexpression of NtPR-Q led to the activation of many defense-related genes, such as salicylic acid (SA-responsive genes NtPR1a/c, NtPR2 and NtCHN50, JA-responsive gene NtPR1b and ET production-associated genes NtACC Oxidase and NtEFE26. Consistent with the role of NtPR-Q in multiple stress responses, NtPR-Q transcripts were induced by the exogenous hormones SA, ethylene and methyl jasmonate, which could enhance the resistance of tobacco to R. solanacearum. Collectively, our results suggested that NtPR-Q overexpression led to the up-regulation of defense-related genes and enhanced plant resistance to R. solanacearum infection.

New window design options for CEBAF energy upgrade

International Nuclear Information System (INIS)

Phillips, L.; Mammosser, J.; Nguyen, V.

1997-01-01

As the Jefferson Laboratory upgrades the existing CEBAF electron accelerator to operate at higher energies, the fundamental power coupler windows will be required to operate with lower RF dissipation and increased immunity to radiation from cavity field emission. New designs and modifications to existing designs which can achieve these goals are described

Multi-scale window specification over streaming trajectories

Directory of Open Access Journals (Sweden)

Kostas Patroumpas

2013-12-01

Full Text Available Enormous amounts of positional information are collected by monitoring applications in domains such as fleet management, cargo transport, wildlife protection, etc. With the advent of modern location-based services, processing such data mostly focuses on providing real-time response to a variety of user requests in continuous and scalable fashion. An important class of such queries concerns evolving trajectories that continuously trace the streaming locations of moving objects, like GPS-equipped vehicles, commodities with RFID's, people with smartphones etc. In this work, we propose an advanced windowing operator that enables online, incremental examination of recent motion paths at multiple resolutions for numerous point entities. When applied against incoming positions, this window can abstract trajectories at coarser representations towards the past, while retaining progressively finer features closer to the present. We explain the semantics of such multi-scale sliding windows through parameterized functions that reflect the sequential nature of trajectories and can effectively capture their spatiotemporal properties. Such window specification goes beyond its usual role for non-blocking processing of multiple concurrent queries. Actually, it can offer concrete subsequences from each trajectory, thus preserving continuity in time and contiguity in space along the respective segments. Further, we suggest language extensions in order to express characteristic spatiotemporal queries using windows. Finally, we discuss algorithms for nested maintenance of multi-scale windows and evaluate their efficiency against streaming positional data, offering empirical evidence of their benefits to online trajectory processing.

Tobacco Transcription Factor NtWRKY12 Interacts With TGA2.2 in vitro and in vivo

Directory of Open Access Journals (Sweden)

Marcel evan Verk

2011-07-01

Full Text Available The promoter of the salicylic acid-inducible PR-1a gene of Nicotiana tabacum contains binding sites for transcription factor NtWRKY12 (WK-box at position -564 and TGA factors (as-1-like element at position -592. Transactivation experiments in Arabidopsis protoplasts derived from wild type, npr1-1, tga256 and tga2356 mutant plants revealed that NtWRKY12 alone was able to induce a PR-1a::β-glucuronidase (GUS reporter gene to high levels, independent of co-expressed tobacco NtNPR1, TGA2.1, TGA2.2 or endogenous Arabidopsis NPR1, TGA2/3/5/6. By in vitro pull-down assays with GST and Strep fusion proteins and by Fluorescence Resonance Energy Transfer assays with protein-CFP and protein-YFP fusions in transfected protoplasts, it was shown that NtWRKY12 and TGA2.2 could interact in vitro and in vivo. Interaction of NtWRKY12 with TGA1a or TGA2.1 was not detectable by these techniques. A possible mechanism for the role of NtWRKY12 and TGA2.2 in PR-1a gene expression is discussed.

Dynamic modeling of the manipulator RD5NT

Directory of Open Access Journals (Sweden)

Eduardo Monteiro Aguiar

2015-05-01

Full Text Available This article presents the development of a dynamicmathematical model for the DIDACTA ITALIARD5NT manipulator. The model is intendedto be used in the development of strategies ofposition-trajectory control. The choice modelingtype aims at identifying the physical parametersof the manipulator.

An Evaluation of Windows-Based Computer Forensics Application Software Running on a Macintosh

OpenAIRE

Gregory H. Carlton

2008-01-01

The two most common computer forensics applications perform exclusively on Microsoft Windows Operating Systems, yet contemporary computer forensics examinations frequently encounter one or more of the three most common operating system environments, namely Windows, OS-X, or some form of UNIX or Linux. Additionally, government and private computer forensics laboratories frequently encounter budget constraints that limit their access to computer hardware. Currently, Macintosh computer systems a...

Visit to the PMS-stations in Estonia, Latvia, Lithuania and Poland

DEFF Research Database (Denmark)

Bargholz, Kim; Andersen, Frank

1998-01-01

Danish build automatic gamma-ray monitoring stations have been installed in the Baltic countries, Poland and Russia (Sct. Petersbourg region). The stations are designed for continously measure the gamma-radiation from the surroundings. The stations use the Windows NT 3.51 as operating system. Eac...

The influence of BANXIAXIEXIN decoction and its analogous preparations on neurotensin (NT) in rat models with reflux esophagitis

International Nuclear Information System (INIS)

Liu Xiaoni; Gao Yanqing; Si Yinchu; Niu Xin

2003-01-01

Objective: To investigate the mechanism of BANXIAXIEXIN TANG Decoction and its analogous preparations in treatment of reflux esophagitis. Methods: 60 rat models with duodenogastroesophageal reflux were divided into 4 equal numbered groups; control group, BANXIAXIEXIN TANG group, SHENGJIANGXIEXIN TANG group, GANCAOXIEXIN TANG group. The contents of NT in hypothalamus, ileum and plasma were measured by radioimmunoassay in all these models and the relationship between NT concentration and degree of esophageal mucosa injury in the control group was analysed. Results: BANXIAXIEXIN Decoction and its analogous preparations could reduce the degree of the esophageal mucosa injury significantly (p<0.01). Compared with the control group: the hypothalamus content of NT in SHENGJIANGXIEXIN TANG group was significantly lowered (p<0.05), the ileum content of NT in BANXIAXIEXIN TANG group was significantly lowered (p<0.01), the plasma contents of NT in both groups were significantly lowered (p<0.05) as well. There was positive correlation (r=0.442, p<0.01) between content of NT in ileum and degree of the esophageal mucosa injury in control group. Conclusion: NT may play an important role in the development reflux esophagitis. Regulating the synthesis and secretion of NT may be one of the mechanisms of BANXIAXIEXIN Decoction and its analogus preparations in treatment of reflux esophagitis

Evaluation of NT-proBNP concentrations during exercise in asymptomatic patients with severe high-gradient aortic stenosis.

Science.gov (United States)

Dobrowolski, Piotr; Lech, Agnieszka; Klisiewicz, Anna; Hoffman, Piotr

2016-08-11

INTRODUCTION The effect of asymptomatic severe aortic stenosis (ASAS) on N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels ar rest and during exercise, as well as their relevance for clinical practice remain controversial.  OBJECTIVES The aim of this study was to test the hypothesis of whether the evaluation of NT-proBNP concentrations during exercise provides additional information about the severity of aortic stenosis and left ventricular remodeling in patients with ASAS. PATIENTS AND METHODS A total of 50 patients with ASAS (mean age, 38.4 ±18.1 years) and 21 healthy subjects (mean age, 43.4 ±10.6 years) were enrolled. Rest and exercise echocardiography was performed to evaluate maximum velocity (Vmax), mean aortic gradient (AG), and aortic valve area (AVA). The left ventricular mass index (LVMI) was calculated. NT-proBNP concentrations at rest and during exercise were assessed, and the difference between the 2 values was calculated (ΔNT-proBNP). RESULTS NT-proBNP and ΔNT-proBNP levels at rest and during exercise were significantly higher in the ASAS group compared with the control group. In the ASAS group, NT-proBNP levels at rest significantly correlated with LVMI (r = 0.432; P <0.0001), AVA (r = -0.408; P <0.0001), Vmax (r = 0.375; P = 0.002), and mean AG (r = 0.257; P = 0.03). NT-proBNP levels during exercise significantly correlated with LVMI (r = 0.432; P <0.0001), mean AG (r = 0.401; P = 0.001), and AVA (r = -0.375; P = 0.001). In the multivariate logistic regression model, the factors independently associated with NT-proBNP both at rest and during exercise were age, AVA, and LVMI. CONCLUSIONS NT-proBNP levels at rest provide valuable information for identifying patients with more advanced left ventricular hypertrophy secondary to severe aortic stenosis. NT-proBNP levels during exercise do not provide new information on the severity of AS.

Relationship of plasma level of NT- ProBNP with development of AF in CABG patients

Directory of Open Access Journals (Sweden)

Tanaray B

2010-10-01

Full Text Available "nBackground: Studies of the association between post operative AF and Plasma level of NT- Pro BNP have reported conflicting findings. The aim of the present study was evaluation of the association between post coronary bypass graft- Atrial Fibrillation (AF and Plasma level of NT- ProBNP as an independent risk factor of AF development in patients undergoing coronary artery bypass graft."n "nMethods: In a cohort study, 79 patients with sinus rhythm who admitted in Imam Khomeini Hospital in Tehran, Iran, during February 2009 and February 2010 for CABG are included the study and followed for developing post operative AF rhythm."n "nResults: Post operative AF was found in 17.7% of patients. The peak time from the operation to the first AF episode was in second post op day in ten patients (71.4%. The serum level of ProBNP in patients with AF was significantly higher (1624± 647 versus 221± 238 pg/ml, p< 0/0001. Increased age, Increased LA size and high plasma level of ProBNP were associated with increased risk for post op AF. After adjustment of risk factors, plasma level of ProBNP was the most important risk factor with odds ratio of 15.34 with CI 95% 1.77-132.95 and then LA diameter with odds ratio of 6.11 with CI 95% 0.99-37.42 was independently correlated with post op AF. Correlation between plasma level of ProBNP with age and LA size was seen too (LA size r = 0.0281, p= 0.012. Between age and ProBNP (r= 0.337, p= 0.002. The best cut off point for plasma ProBNP as a predictor of post op AF was 854 pg/ml."n "nConclusion: Increased level of preoperative ProBNP levels could be an independent predictor of post operative Atrial Fibrillation.

Preconditioners based on windowed Fourier frames applied to elliptic partial differential equations

NARCIS (Netherlands)

Bhowmik, S.K.; Stolk, C.C.

2011-01-01

We investigate the application of windowed Fourier frames to the numerical solution of partial differential equations, focussing on elliptic equations. The action of a partial differential operator (PDO) on a windowed plane wave is close to a multiplication, where the multiplication factor is given

Development of C-band High-Power Mix-Mode RF Window

CERN Document Server

Michizono, S; Matsumoto, T; Nakao, K; Takenaka, T

2004-01-01

High power c-band (5712 MHz) rf system (40 MW, 2 μs, 50 Hz) is under consideration for the electron-linac upgrade aimed for the super KEKB project. An rf window, which isolates the vacuum and pass the rf power, is one of the most important components for the rf system. The window consists of a ceramic disk and a pill-box housing. The mix-mode rf window is designed so as to decrease the electric field on the periphery of the ceramic disk. A resonant ring is assembled in order to examine the high-power transmission test. The window was tested up to the transmission power of 160 MW. The rf losses are also measured during the rf operation.

Expression of neurotensin and NT1 receptor in human breast cancer: a potential role in tumor progression.

Science.gov (United States)

Souazé, Frédérique; Dupouy, Sandra; Viardot-Foucault, Véronique; Bruyneel, Erik; Attoub, Samir; Gespach, Christian; Gompel, Anne; Forgez, Patricia

2006-06-15

Emerging evidence supports neurotensin as a trophic and antiapoptotic factor, mediating its control via the high-affinity neurotensin receptor (NT1 receptor) in several human solid tumors. In a series of 51 patients with invasive ductal breast cancers, 34% of all tumors were positive for neurotensin and 91% positive for NT1 receptor. We found a coexpression of neurotensin and NT1 receptor in a large proportion (30%) of ductal breast tumors, suggesting a contribution of the neurotensinergic signaling cascade within breast cancer progression. Functionally expressed NT1 receptor, in the highly malignant MDA-MB-231 human breast cancer cell line, coordinated a series of transforming functions, including cellular migration, invasion, induction of the matrix metalloproteinase (MMP)-9 transcripts, and MMP-9 gelatinase activity. Disruption of NT1 receptor signaling by silencing RNA or use of a specific NT1 receptor antagonist, SR48692, caused the reversion of these transforming functions and tumor growth of MDA-MB-231 cells xenografted in nude mice. Our findings support the contribution of neurotensin in human breast cancer progression and point out the utility to develop therapeutic molecules targeting neurotensin or NT1 receptor signaling cascade. These strategies would increase the range of therapeutic approaches and be beneficial for specific patients.

Spore Coat Architecture of Clostridium novyi-NT spores

Energy Technology Data Exchange (ETDEWEB)

Plomp, M; McCafferey, J; Cheong, I; Huang, X; Bettegowda, C; Kinzler, K; Zhou, S; Vogelstein, B; Malkin, A

2007-05-07

Spores of the anaerobic bacterium Clostridium novyi-NT are able to germinate in and destroy hypoxic regions of tumors in experimental animals. Future progress in this area will benefit from a better understanding of the germination and outgrowth processes that are essential for the tumorilytic properties of these spores. Towards this end, we have used both transmission electron microscopy and atomic force microscopy to determine the structure of dormant as well as germinating spores. We found that the spores are surrounded by an amorphous layer intertwined with honeycomb parasporal layers. Moreover, the spore coat layers had apparently self-assembled and this assembly was likely to be governed by crystal growth principles. During germination and outgrowth, the honeycomb layers as well as the underlying spore coat and undercoat layers sequentially dissolved until the vegetative cell was released. In addition to their implications for understanding the biology of C. novyi-NT, these studies document the presence of proteinaceous growth spirals in a biological organism.

Windows 2012 Server network security securing your Windows network systems and infrastructure

CERN Document Server

Rountree, Derrick

2013-01-01

Windows 2012 Server Network Security provides the most in-depth guide to deploying and maintaining a secure Windows network. The book drills down into all the new features of Windows 2012 and provides practical, hands-on methods for securing your Windows systems networks, including: Secure remote access Network vulnerabilities and mitigations DHCP installations configuration MAC filtering DNS server security WINS installation configuration Securing wired and wireless connections Windows personal firewall

MRI-Monitored Intra-Tumoral Injection of Iron-Oxide Labeled Clostridium novyi-NT Anaerobes in Pancreatic Carcinoma Mouse Model

Science.gov (United States)

Zheng, Linfeng; Zhang, Zhuoli; Khazaie, Khashayarsha; Saha, Saurabh; Lewandowski, Robert J.; Zhang, Guixiang; Larson, Andrew C.

2014-01-01

Objectives To validate the feasibility of labeling Clostridium novyi-NT (C.novyi-NT) anaerobes with iron-oxide nanoparticles for magnetic resonance imaging (MRI) and demonstrate the potential to use MRI to visualize intra-tumoral delivery of these iron-oxide labeled C.novyi-NT during percutaneous injection procedures. Materials and Methods All studies were approved by IACUC. C.novyi-NT were labeled with hybrid iron-oxide Texas red nanoparticles. Growth of labeled and control samples were evaluated with optical density. Labeling was confirmed with confocal fluorescence and transmission electron microscopy (TEM). MRI were performed using a 7 Tesla scanner with T2*-weighted (T2*W) sequence. Contrast-to-noise ratio (CNR) measurements were performed for phantoms and signal-to-noise ratio (SNR) measurements performed in C57BL/6 mice (n = 12) with Panc02 xenografts before and after percutaneous injection of iron-oxide labeled C.novyi-NT. MRI was repeated 3 and 7 days post-injection. Hematoxylin-eosin (HE), Prussian blue and Gram staining of tumor specimens were performed for confirmation of intra-tumoral delivery. Results Iron-oxide labeling had no influence upon C.novyi-NT growth. The signal intensity (SI) within T2*W images was significantly decreased for iron-oxide labeled C.novyi-NT phantoms compared to unlabeled controls. Under confocal fluorescence microscopy, the iron-oxide labeled C.novyi-NT exhibited a uniform red fluorescence consistent with observed regions of DAPI staining and overall labeling efficiency was 100% (all DAPI stained C.novyi-NT exhibited red fluorescence). Within TEM images, a large number iron granules were observed within the iron-oxide labeled C.novyi-NT; these were not observed within unlabeled controls. Intra-procedural MRI measurements permitted in vivo visualization of the intra-tumoral distribution of iron-oxide labeled C.novyi-NT following percutaneous injection (depicted as punctate regions of SI reductions within T2*-weighted

The economics of window selection: An incremental approach

International Nuclear Information System (INIS)

Dixon, W.T.

1993-01-01

The options available to Energy Service Companies when improving the energy performance of an existing building are often driven by short-term payback cycles. The value of a measure is based on how quickly it pays for itself. The more quickly the energy savings created by the measure exceed the cost of purchasing and installing the measure, the more comfortable the engineer feels recommending that improvement. In the best cases, the short-term approach will quickly retire the debts associated with a particular retrofit and provide a dependable, albeit limited net savings stream for the property owner. The engineer has obtained energy savings for his client. The problem with this short-term approach is that it automatically eliminates other conservation measures which, over longer time horizons, could add far more value for the customer. The installation of new, extremely energy efficient replacement windows is a case in point. During preliminary discussions with our clients, (typically Public Housing Authorities or owners of subsidized, multi-family housing), the conversation eventually turns to the issue of replacement windows. The perception is that new windows are a luxury. The decision to install new windows is driven by maintenance costs and, in some cases, resident complaints over operability or draftiness associated with the existing windows. Typically the windows are not handled as part of the mainstream energy conservation program. If the client has already installed new windows, he probably based his selection on the low bidder of a unit that has marginal thermal performance. Every property has a budget and compromises must often be made to meet budgets. The purchaser may have not gotten the Cadillac of windows, but at least he got a good deal on the window that he did buy. His maintenance problems have been solved for the near term and resident complaints have gone down, for now

High power tests of X-band RF windows at KEK

Energy Technology Data Exchange (ETDEWEB)

Otake, Yuji [Earthquake Research Inst., Tokyo Univ., Tokyo (Japan); Tokumoto, Shuichi; Kazakov, Sergei Yu.; Odagiri, Junichi; Mizuno, Hajime

1997-04-01

Various RF windows comprising a short pill-box, a long pill-box, a TW (traveling wave)-mode and three TE11-mode horn types have been developed for an X-band high-power pulse klystron with two output windows for JLC (Japan Linear Collider). The output RF power of the klystron is designed to be 130 MW with the 800 ns pulse duration. Since this X-band klystron has two output windows, the maximum RF power of the window must be over 85 MW. The design principle for the windows is to reduce the RF-power density and/or the electric-field strength at the ceramic part compared with that of an ordinary pill-box-type window. Their reduction is effective to increase the handling RF power of the window. To confirm that the difference among the electric-field strengths depends on their RF structures, High-power tests of the above-mentioned windows were successfully carried out using a traveling-wave resonator (TWR) for the horns and the TW-mode type and, installing them directly to klystron output waveguides for the short and long pill-box type. Based upon the operation experience of S-band windows, two kinds of ceramic materials were used for these tests. The TE11-mode 1/2{lambda}g-1 window was tested up to the RF peak-power of 84 MW with the 700 ns pulse duration in the TWR. (J.P.N)

Similar pro-NT and pro-RLX2 levels after preeclampsia and after uncomplicated pregnancy

NARCIS (Netherlands)

Zoet, G. A.(Gerbrand); van Rijn, B. B.(Bas); Rehfeldt, M. (Miriam); Franx, A. (Arie); Maas, Angela H E M

2017-01-01

OBJECTIVE: Women are at increased risk of developing cardiovascular disease (CVD) after preeclampsia. Proneurotensin 1-117 (pro-NT) and prorelaxin 2 connecting peptide (pro-RLX2) have recently emerged as potential biomarkers for CVD risk in women. We assessed pro-NT and pro-RLX2 levels in women with

Similar pro-NT and pro-RLX2 levels after preeclampsia and after uncomplicated pregnancy

NARCIS (Netherlands)

Zoet, G. A.(Gerbrand); van Rijn, B. B.(Bas); Rehfeldt, M. (Miriam); Franx, A. (Arie); Maas, Angela H E M

2017-01-01

Objective Women are at increased risk of developing cardiovascular disease (CVD) after preeclampsia. Proneurotensin 1-117 (pro-NT) and prorelaxin 2 connecting peptide (pro-RLX2) have recently emerged as potential biomarkers for CVD risk in women. We assessed pro-NT and pro-RLX2 levels in women with

Hypersensitive detection and quantitation of BoNT/A by IgY antibody against substrate linear-peptide.

Directory of Open Access Journals (Sweden)

Tao Li

Full Text Available Botulinum neurotoxin A (BoNT/A, the most acutely poisonous substance to humans known, cleave its SNAP-25 substrate with high specificity. Based on the endopeptidase activity, different methods have been developed to detect BoNT/A, but most lack ideal reproducibility or sensitivity, or suffer from long-term or unwanted interferences. In this study, we developed a simple method to detect and quantitate trace amounts of botulinum neurotoxin A using the IgY antibody against a linear-peptide substrate. The effects of reaction buffer, time, and temperature were analyzed and optimized. When the optimized assay was used to detect BoNT/A, the limit of detection of the assay was 0.01 mouse LD50 (0.04 pg, and the limit of quantitation was 0.12 mouse LD50/ml (0.48 pg. The findings also showed favorable specificity of detecting BoNT/A. When used to detect BoNT/A in milk or human serum, the proposed assay exhibited good quantitative accuracy (88% < recovery < 111%; inter- and intra-assay CVs < 18%. This method of detection took less than 3 h to complete, indicating that it can be a valuable method of detecting BoNT/A in food or clinical diagnosis.

Controlling Access to Input/Output Peripheral Devices

Directory of Open Access Journals (Sweden)

E. Y. Rodionov

2010-03-01

Full Text Available In this paper the author proposes a system that manages information security policy on enterprise. Problems related to managing information security policy on enterprise and access to peripheral devices in computer systems functioning under control of Microsoft Windows NT operating systems are considered.

In-Vivo Neutralization of Botulinum Neurotoxin Serotype E Using Rabbit Polyclonal Antibody Developed against BoNT/E Light Chain.

Science.gov (United States)

Rani, Sarita; Ponmariappan, S; Sharma, Arti; Kamboj, D V; Jain, A K

2017-01-01

Clostridium botulinum is an obligate anaerobic, Gram positive bacterium that secretes extremely toxic substances known as botulinum neurotoxins (BoNTs) that cause serious paralytic illness called botulism. Based upon the serological properties, these neurotoxin have been classified into seven serotypes designated from A to G. Due to extreme toxicity of BoNTs, these neurotoxins have been designated as category A biowarfare agents. There is no commercial neutralizing antibody available for the treatment of botulism. Hence there is an urgent need to develop therapeutic intervention for prevention and cure of botulism within short period. BoNT antiserum injection is still the effective treatment. In the present study, the recombinant light chain of BoNT/E was successfully purified in soluble form. The purified rBoNT/E LC was used for the generation of polyclonal antibody in rabbit. In order to find out the neutralizing capacity of generated antisera, rabbit antiserum was incubated with 20 LD50 of botulinum neurotoxin type E for 1 hour at 37°C and then injected intraperitoneally (IP) into mice. Further in another set of experiments antiserum was administered in different ways that included administration of - antiserum and BoNT/E toxin simultaneously without preincubation, one after another at the same and different time points for its therapeutic ability. To find out cross neutralization capacity, rBoNT/E LC antiserum was pre-incubated with 5 LD50 of BoNT/A, BoNT/B, BoNT/F and then injected (IP) into mice. In all the cases mice were observed continuously for 96 hours. The results clearly indicate that developed polyclonal rabbit antiserum showed serotype specific neutralization of BoNT/E toxin only but not of BoNT/A, BoNT/B and BoNT/F. The developed antibodies will be used for preventive and therapeutic intervention of type 'E' botulism. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Programming Windows® Embedded CE 60 Developer Reference

CERN Document Server

Boling, Douglas

2010-01-01

Get the popular, practical reference to developing small footprint applications-now updated for the Windows Embedded CE 6.0 kernel. Written by an authority on embedded application development, this book focuses in on core operating concepts and the Win32 API. It delivers extensive code samples and sample projects-helping you build proficiency creating innovative Windows applications for a new generation of devices. Discover how to: Create complex applications designed for the unique requirements of embedded devicesManage virtual memory, heaps, and the stack to minimize your memory footprintC

Prognostic significance of tumor size of small lung adenocarcinomas evaluated with mediastinal window settings on computed tomography.

Directory of Open Access Journals (Sweden)

Yukinori Sakao

Full Text Available BACKGROUND: We aimed to clarify that the size of the lung adenocarcinoma evaluated using mediastinal window on computed tomography is an important and useful modality for predicting invasiveness, lymph node metastasis and prognosis in small adenocarcinoma. METHODS: We evaluated 176 patients with small lung adenocarcinomas (diameter, 1-3 cm who underwent standard surgical resection. Tumours were examined using computed tomography with thin section conditions (1.25 mm thick on high-resolution computed tomography with tumour dimensions evaluated under two settings: lung window and mediastinal window. We also determined the patient age, gender, preoperative nodal status, tumour size, tumour disappearance ratio, preoperative serum carcinoembryonic antigen levels and pathological status (lymphatic vessel, vascular vessel or pleural invasion. Recurrence-free survival was used for prognosis. RESULTS: Lung window, mediastinal window, tumour disappearance ratio and preoperative nodal status were significant predictive factors for recurrence-free survival in univariate analyses. Areas under the receiver operator curves for recurrence were 0.76, 0.73 and 0.65 for mediastinal window, tumour disappearance ratio and lung window, respectively. Lung window, mediastinal window, tumour disappearance ratio, preoperative serum carcinoembryonic antigen levels and preoperative nodal status were significant predictive factors for lymph node metastasis in univariate analyses; areas under the receiver operator curves were 0.61, 0.76, 0.72 and 0.66, for lung window, mediastinal window, tumour disappearance ratio and preoperative serum carcinoembryonic antigen levels, respectively. Lung window, mediastinal window, tumour disappearance ratio, preoperative serum carcinoembryonic antigen levels and preoperative nodal status were significant factors for lymphatic vessel, vascular vessel or pleural invasion in univariate analyses; areas under the receiver operator curves were 0

Prognostic Significance of Tumor Size of Small Lung Adenocarcinomas Evaluated with Mediastinal Window Settings on Computed Tomography

Science.gov (United States)

Sakao, Yukinori; Kuroda, Hiroaki; Mun, Mingyon; Uehara, Hirofumi; Motoi, Noriko; Ishikawa, Yuichi; Nakagawa, Ken; Okumura, Sakae

2014-01-01

Background We aimed to clarify that the size of the lung adenocarcinoma evaluated using mediastinal window on computed tomography is an important and useful modality for predicting invasiveness, lymph node metastasis and prognosis in small adenocarcinoma. Methods We evaluated 176 patients with small lung adenocarcinomas (diameter, 1–3 cm) who underwent standard surgical resection. Tumours were examined using computed tomography with thin section conditions (1.25 mm thick on high-resolution computed tomography) with tumour dimensions evaluated under two settings: lung window and mediastinal window. We also determined the patient age, gender, preoperative nodal status, tumour size, tumour disappearance ratio, preoperative serum carcinoembryonic antigen levels and pathological status (lymphatic vessel, vascular vessel or pleural invasion). Recurrence-free survival was used for prognosis. Results Lung window, mediastinal window, tumour disappearance ratio and preoperative nodal status were significant predictive factors for recurrence-free survival in univariate analyses. Areas under the receiver operator curves for recurrence were 0.76, 0.73 and 0.65 for mediastinal window, tumour disappearance ratio and lung window, respectively. Lung window, mediastinal window, tumour disappearance ratio, preoperative serum carcinoembryonic antigen levels and preoperative nodal status were significant predictive factors for lymph node metastasis in univariate analyses; areas under the receiver operator curves were 0.61, 0.76, 0.72 and 0.66, for lung window, mediastinal window, tumour disappearance ratio and preoperative serum carcinoembryonic antigen levels, respectively. Lung window, mediastinal window, tumour disappearance ratio, preoperative serum carcinoembryonic antigen levels and preoperative nodal status were significant factors for lymphatic vessel, vascular vessel or pleural invasion in univariate analyses; areas under the receiver operator curves were 0.60, 0.81, 0

Overexpression of NtWRKY50 Increases Resistance to Ralstonia solanacearum and Alters Salicylic Acid and Jasmonic Acid Production in Tobacco.

Science.gov (United States)

Liu, Qiuping; Liu, Ying; Tang, Yuanman; Chen, Juanni; Ding, Wei

2017-01-01

WRKY transcription factors (TFs) modulate plant responses to biotic and abiotic stresses. Here, we characterized a WRKY IIc TF, NtWRKY50, isolated from tobacco ( Nicotiana tabacum ) plants. The results showed that NtWRKY50 is a nuclear-localized protein and that its gene transcript is induced in tobacco when inoculated with the pathogenic bacterium Ralstonia solanacearum . Overexpression of NtWRKY50 enhanced bacterial resistance, which correlated with enhanced SA and JA/ET signaling genes. However, silencing of the NtWRKY50 gene had no obvious effects on plant disease resistance, implying functional redundancy of NtWRKY50 with other TFs. In addition, it was found that NtWRKY50 can be induced by various biotic or abiotic stresses, such as Potato virus Y, Rhizoctonia solani, Phytophthora parasitica , hydrogen peroxide, heat, cold, and wounding as well as the hormones salicylic acid (SA), jasmonic acid (JA), and ethylene (ET). Importantly, additional analysis suggests that NtWRKY50 overexpression markedly promotes SA levels but prevents pathogen-induced JA production. These data indicate that NtWRKY50 overexpression leads to altered SA and JA content, increased expression of defense-related genes and enhanced plant resistance to R. solanacearum. These probably due to increased activity of endogenous NtWRKY50 gene or could be gain-of-function phenotypes by altering the profile of genes affected by NtWRKY50 .

NT-proBNP levels, atherosclerosis and vascular function in asymptomatic type 2 diabetic patients with microalbuminuria: peripheral reactive hyperaemia index but not NT-proBNP is an independent predictor of coronary atherosclerosis

DEFF Research Database (Denmark)

Reinhard, Henrik; Wiinberg, Niels; Hansen, Peter R

2011-01-01

Intensive multifactorial treatment aimed at cardiovascular (CV) risk factor reduction in type 2 diabetic patients with microalbuminuria can diminish fatal and non-fatal CV. Plasma N-terminal (NT)-proBNP predicts CV mortality in diabetic patients but the utility of P-NT-proBNP in screening for ath......-media thickness (CIMT)>0.90 mm, ankle-brachial index...

Windows Vista Annoyances Tips, Secrets, and Hacks for the Cranky Consumer

CERN Document Server

Karp, David

2008-01-01

Windows Vista may be the next big thing, but it still contains enough quirks and unaccountable behaviors to vex anyone. This unique guide not only discusses the most irritating features of the latest Microsoft operating system and how to get around them, but also explains how to improve Windows and do more with the software than Microsoft intended. You'll find information on setup, installation, upgrade from other Windows versions, the revamped interface, new security features, user accounts, troubleshooting, and the markedly improved Internet Explorer 7. Other chapters cover a wide range of

Random mutagenesis of BoNT/E Hc nanobody to construct a secondary phage-display library.

Science.gov (United States)

Shahi, B; Mousavi Gargari, S L; Rasooli, I; Rajabi Bazl, M; Hoseinpoor, R

2014-08-01

To construct secondary mutant phage-display library of recombinant single variable domain (VHH) against botulinum neurotoxin E by error-prone PCR. The gene coding for specific VHH derived from the camel immunized with binding domain of botulinum neurotoxin E (BoNT/E) was amplified by error-prone PCR. Several biopanning rounds were used to screen the phage-displaying BoNT/E Hc nanobodies. The final nanobody, SHMR4, with increased affinity recognized BoNT/E toxin with no cross-reactivity with other antigens especially with related BoNT toxins. The constructed nanobody could be a suitable candidate for VHH-based biosensor production to detect the Clostridium botulinum type E. Diagnosis and treatment of botulinum neurotoxins are important. Generation of high-affinity antibodies based on the construction of secondary libraries using affinity maturation step leads to the development of reagents for precise diagnosis and therapy. © 2014 The Society for Applied Microbiology.

Operation of a free-electron laser from the extreme ultraviolet to the water window

Science.gov (United States)

Ackermann, W.; Asova, G.; Ayvazyan, V.; Azima, A.; Baboi, N.; Bähr, J.; Balandin, V.; Beutner, B.; Brandt, A.; Bolzmann, A.; Brinkmann, R.; Brovko, O. I.; Castellano, M.; Castro, P.; Catani, L.; Chiadroni, E.; Choroba, S.; Cianchi, A.; Costello, J. T.; Cubaynes, D.; Dardis, J.; Decking, W.; Delsim-Hashemi, H.; Delserieys, A.; di Pirro, G.; Dohlus, M.; Düsterer, S.; Eckhardt, A.; Edwards, H. T.; Faatz, B.; Feldhaus, J.; Flöttmann, K.; Frisch, J.; Fröhlich, L.; Garvey, T.; Gensch, U.; Gerth, Ch.; Görler, M.; Golubeva, N.; Grabosch, H.-J.; Grecki, M.; Grimm, O.; Hacker, K.; Hahn, U.; Han, J. H.; Honkavaara, K.; Hott, T.; Hüning, M.; Ivanisenko, Y.; Jaeschke, E.; Jalmuzna, W.; Jezynski, T.; Kammering, R.; Katalev, V.; Kavanagh, K.; Kennedy, E. T.; Khodyachykh, S.; Klose, K.; Kocharyan, V.; Körfer, M.; Kollewe, M.; Koprek, W.; Korepanov, S.; Kostin, D.; Krassilnikov, M.; Kube, G.; Kuhlmann, M.; Lewis, C. L. S.; Lilje, L.; Limberg, T.; Lipka, D.; Löhl, F.; Luna, H.; Luong, M.; Martins, M.; Meyer, M.; Michelato, P.; Miltchev, V.; Möller, W. D.; Monaco, L.; Müller, W. F. O.; Napieralski, O.; Napoly, O.; Nicolosi, P.; Nölle, D.; Nuñez, T.; Oppelt, A.; Pagani, C.; Paparella, R.; Pchalek, N.; Pedregosa-Gutierrez, J.; Petersen, B.; Petrosyan, B.; Petrosyan, G.; Petrosyan, L.; Pflüger, J.; Plönjes, E.; Poletto, L.; Pozniak, K.; Prat, E.; Proch, D.; Pucyk, P.; Radcliffe, P.; Redlin, H.; Rehlich, K.; Richter, M.; Roehrs, M.; Roensch, J.; Romaniuk, R.; Ross, M.; Rossbach, J.; Rybnikov, V.; Sachwitz, M.; Saldin, E. L.; Sandner, W.; Schlarb, H.; Schmidt, B.; Schmitz, M.; Schmüser, P.; Schneider, J. R.; Schneidmiller, E. A.; Schnepp, S.; Schreiber, S.; Seidel, M.; Sertore, D.; Shabunov, A. V.; Simon, C.; Simrock, S.; Sombrowski, E.; Sorokin, A. A.; Spanknebel, P.; Spesyvtsev, R.; Staykov, L.; Steffen, B.; Stephan, F.; Stulle, F.; Thom, H.; Tiedtke, K.; Tischer, M.; Toleikis, S.; Treusch, R.; Trines, D.; Tsakov, I.; Vogel, E.; Weiland, T.; Weise, H.; Wellhöfer, M.; Wendt, M.; Will, I.; Winter, A.; Wittenburg, K.; Wurth, W.; Yeates, P.; Yurkov, M. V.; Zagorodnov, I.; Zapfe, K.

2007-06-01

We report results on the performance of a free-electron laser operating at a wavelength of 13.7 nm where unprecedented peak and average powers for a coherent extreme-ultraviolet radiation source have been measured. In the saturation regime, the peak energy approached 170 µJ for individual pulses, and the average energy per pulse reached 70 µJ. The pulse duration was in the region of 10 fs, and peak powers of 10 GW were achieved. At a pulse repetition frequency of 700 pulses per second, the average extreme-ultraviolet power reached 20 mW. The output beam also contained a significant contribution from odd harmonics of approximately 0.6% and 0.03% for the 3rd (4.6 nm) and the 5th (2.75 nm) harmonics, respectively. At 2.75 nm the 5th harmonic of the radiation reaches deep into the water window, a wavelength range that is crucially important for the investigation of biological samples.

The nT1 translocation separates vulval regulatory elements from the egl-18 and elt-6 GATA factor genes.

Science.gov (United States)

Koh, Kyunghee; Bernstein, Yelena; Sundaram, Meera V

2004-03-01

egl-18 and elt-6 are partially redundant, adjacent genes encoding GATA factors essential for viability, seam cell development, and vulval development in Caenorhabditis elegans. The nT1 reciprocal translocation causes a strong Vulvaless phenotype, and an nT1 breakpoint was previously mapped to the left arm of LGIV, where egl-18/elt-6 are located. Here we present evidence that the nT1 vulval phenotype is due to a disruption of egl-18/elt-6 function specifically in the vulva. egl-18 mutations do not complement nT1 for vulval defects, and the nT1 breakpoint on LGIV is located within approximately 800 bp upstream of a potential transcriptional start site of egl-18. In addition, we have identified a approximately 350-bp cis-regulatory region sufficient for vulval expression just upstream of the nT1 breakpoint. By examining the fusion state and division patterns of the cells in the developing vulva of nT1 mutants, we demonstrate that egl-18/elt-6 prevent fusion and promote cell proliferation at multiple steps of vulval development.

Infecting Windows, Linux & Mac in one go

CERN Multimedia

Computer Security Team

2012-01-01

Still love bashing on Windows as you believe it is an insecure operating system? Hold on a second! Just recently, a vulnerability has been published for Java 7.   It affects Windows/Linux PCs and Macs, Internet Explorer, Safari and Firefox. In fact, it affects all computers that have enabled the Java 7 plug-in in their browser (Java 6 and earlier is not affected). Once you visit a malicious website (and there are plenty already out in the wild), your computer is infected… That's "Game Over" for you.      And this is not the first time. For a while now, attackers have not been targeting the operating system itself, but rather aiming at vulnerabilities inherent in e.g. your Acrobat Reader, Adobe Flash or Java programmes. All these are standard plug-ins added into your favourite web browser which make your web-surfing comfortable (or impossible when you un-install them). A single compromised web-site, however, is sufficient to prob...

Mixed - mode Operating System for Real - time Performance

Directory of Open Access Journals (Sweden)

Hasan M. M.

2017-11-01

Full Text Available The purpose of the mixed-mode system research is to handle devices with the accuracy of real-time systems and at the same time, having all the benefits and facilities of a matured Graphic User Interface(GUIoperating system which is typicallynon-real-time. This mixed-mode operating system comprising of a real-time portion and a non-real-time portion was studied and implemented to identify the feasibilities and performances in practical applications (in the context of scheduled the real-time events. In this research an i8751 microcontroller-based hardware was used to measure the performance of the system in real-time-only as well as non-real-time-only configurations. The real-time portion is an 486DX-40 IBM PC system running under DOS-based real-time kernel and the non-real-time portion is a Pentium IIIbased system running under Windows NT. It was found that mixed-mode systems performed as good as a typical real-time system and in fact, gave many additional benefits such as simplified/modular programming and load tolerance.

Fast reactor fuel reprocessing plant D1206: disassembly cave window 4 replacement

International Nuclear Information System (INIS)

Sutherland, H.G.; Beckitt, S.; Potts, A.B.

1996-01-01

At UKAEA's fast reactor reprocessing plant at Dounreay, the containment glass on the zinc bromide cave viewing window tank failed after 13 years active use. External shielding was fitted and the window tank subsequently drained to make it safe. Fuel cropping operations carried out behind the window were resited to enable cave work to continue whilst a project team made arrangements and plans to replace the damaged window. Because of the complexity of the task and high (alpha, beta, gamma and neutron) radiation levels in excess of 500 Sv/hr a rehearsal facility was built to develop the remote handling techniques to be employed in the task. (UK)

Efficient Windows Collaborative

Energy Technology Data Exchange (ETDEWEB)

Nils Petermann

2010-02-28

The project goals covered both the residential and commercial windows markets and involved a range of audiences such as window manufacturers, builders, homeowners, design professionals, utilities, and public agencies. Essential goals included: (1) Creation of 'Master Toolkits' of information that integrate diverse tools, rating systems, and incentive programs, customized for key audiences such as window manufacturers, design professionals, and utility programs. (2) Delivery of education and outreach programs to multiple audiences through conference presentations, publication of articles for builders and other industry professionals, and targeted dissemination of efficient window curricula to professionals and students. (3) Design and implementation of mechanisms to encourage and track sales of more efficient products through the existing Window Products Database as an incentive for manufacturers to improve products and participate in programs such as NFRC and ENERGY STAR. (4) Development of utility incentive programs to promote more efficient residential and commercial windows. Partnership with regional and local entities on the development of programs and customized information to move the market toward the highest performing products. An overarching project goal was to ensure that different audiences adopt and use the developed information, design and promotion tools and thus increase the market penetration of energy efficient fenestration products. In particular, a crucial success criterion was to move gas and electric utilities to increase the promotion of energy efficient windows through demand side management programs as an important step toward increasing the market share of energy efficient windows.

Materials And Devices In Electrochromic Window Development

Science.gov (United States)

Cogan, Stuart F.; Anderson, Elizabeth J.; Plante, Timothy D.; Rauh, R. David

1985-12-01

Windows with switchable electrochromic glazings are potentially useful for regulating solar input to building interiors. In this article, we describe the structure and operation of a proposed solid-state electrochromic glazing based on crystalline LixWO3 (c-LiXWO3) and a low coloration efficiency counter electrode material such as amorphous Nb2O5 (a-Nb2O5). The importance of reversibility in electrochromic glazing operation is emphasized, and optical switching experiments that demonstrate reversible lithium insertion/extraction in c-LixW03, a-LixWO3, and a-LixNb2O5 are described. Additional optical switching experiments in tandem electrochromic cells comprised of c-LixWO3/a-Nb2O5 and a-LixWO3/a-Nb2O5 demonstrated the proposed design, indicating reversible optical switching over 500 and 200 complete cycles, respectively, without degradation. Optical data on the evolution of reflective and absorp-tive modulation in c-LixWO3 are presented and solar attenuation results are used to demon-strate the advantage of using crystalline electrochromics to conserve daylighting during electrochromic window operation.

Perbandingan proxy pada linux dan windows untuk mempercepat browsing website

Directory of Open Access Journals (Sweden)

Dafwen Toresa

2017-05-01

Full Text Available AbstrakPada saat ini sangat banyak organisasi, baik pendidikan, pemerintahan,  maupun perusahaan swasta berusaha membatasi akses para pengguna ke internet dengan alasan bandwidth yang dimiliki mulai terasa lambat ketika para penggunanya mulai banyak yang melakukan browsing ke internet. Mempercepat akses browsing menjadi perhatian utama dengan memanfaatkan teknologi Proxy server. Penggunaan proxy server perlu mempertimbangkan sistem operasi pada server dan tool yang digunakan belum diketahui performansi terbaiknya pada sistem operasi apa.  Untuk itu dirasa perlu untuk menganalisis performan Proxy server pada sistem operasi berbeda yaitu Sistem Operasi Linux dengan tools Squid  dan Sistem Operasi Windows dengan tool Winroute. Kajian ini dilakukan untuk mengetahui perbandingan kecepatan browsing dari komputer pengguna (client. Browser yang digunakan di komputer pengguna adalah Mozilla Firefox. Penelitian ini menggunakan 2 komputer klien dengan pengujian masing-masingnya 5 kali pengujian pengaksesan/browsing web yang dituju melalui proxy server. Dari hasil pengujian yang dilakukan, diperoleh kesimpulan bahwa penerapan proxy server di sistem operasi linux dengan tools squid lebih cepat browsing dari klien menggunakan web browser yang sama dan komputer klien yang berbeda dari pada proxy server sistem operasi windows dengan tools winroute.  Kata kunci: Proxy, Bandwidth, Browsing, Squid, Winroute AbstractAt this time very many organizations, both education, government, and private companies try to limit the access of users to the internet on the grounds that the bandwidth owned began to feel slow when the users began to do a lot of browsing to the internet. Speed up browsing access is a major concern by utilizing Proxy server technology. The use of proxy servers need to consider the operating system on the server and the tool used is not yet known the best performance on what operating system. For that it is necessary to analyze Performance Proxy

Physics capabilities of the second stage Baikal detector NT-200

International Nuclear Information System (INIS)

Spiering, C.; Heller, R.; Heukenkamp, H.; Krabi, J.; Mikolajski, T.; Thon, T.; Wischnewski, R.; Alatin, S.D.; Fialkovsky, S.V.; Kulepov, V.F.; Milenin, M.B.; Belolaptikov, I.A.; Bezrukov, L.B.; Borisovets, B.A.; Bugaev, E.V.; Djilkibaev, Zh.A.M.; Domogatsky, G.V.; Donskich, L.A.; Doroshenko, A.A.; Galperin, M.D.; Gushtan, M.N.; Klabukov, A.M.; Klimushin, S.I.; Lanin, O.J.; Lubsandorzhiev, B.K.; Ogievietzky, N.V.; Panfilov, A.I.; Sokalsky, I.A.; Trofimenko, I.I.; Budnev, N.M.; Chensky, A.G.; Dobrynin, V.I.; Gress, O.A.; Koshechkin, A.P.; Lanin, J.B.; Litunenko, G.A.; Lopin, A.L.; Naumov, V.A.; Nemchenko, M.I.; Parfenov, Yu.V.; Pavlov, A.A.; Pokalev, O.P.; Primin, V.A.; Sumanov, A.A.; Tarashansky, V.A.; Zurbanov, V.L.; Dudkin, G.N.; Egorov, V.Yu.; Lukanin, A.A.; Ovcharov, A.M.; Padalko, V.M.; Padusenko, A.H.; Golikov, A.V.; Kabikov, V.B.; Kuzmichov, L.A.; Osipova, E.A.; Zaslavskaya, E.S.; Jenek, L.; Kiss, D.; Tanko, L.; Kusner, Yu.S.; Poleschuk, V.A.; Sherstyankin, P.P.; Levin, A.A.; Nikiforov, A.I.; Rosanov, M.I.

1991-12-01

We describe the lake Baikal deep underwater detector 'NT-200' and discuss its physics capabilities to investigate problems in the field of neutrino astrophysics, cosmic ray physics and particle physics. (orig.)

Hot Cell Window Shielding Analysis Using MCNP

International Nuclear Information System (INIS)

Pope, Chad L.; Scates, Wade W.; Taylor, J. Todd

2009-01-01

The Idaho National Laboratory Materials and Fuels Complex nuclear facilities are undergoing a documented safety analysis upgrade. In conjunction with the upgrade effort, shielding analysis of the Fuel Conditioning Facility (FCF) hot cell windows has been conducted. This paper describes the shielding analysis methodology. Each 4-ft thick window uses nine glass slabs, an oil film between the slabs, numerous steel plates, and packed lead wool. Operations in the hot cell center on used nuclear fuel (UNF) processing. Prior to the shielding analysis, shield testing with a gamma ray source was conducted, and the windows were found to be very effective gamma shields. Despite these results, because the glass contained significant amounts of lead and little neutron absorbing material, some doubt lingered regarding the effectiveness of the windows in neutron shielding situations, such as during an accidental criticality. MCNP was selected as an analysis tool because it could model complicated geometry, and it could track gamma and neutron radiation. A bounding criticality source was developed based on the composition of the UNF. Additionally, a bounding gamma source was developed based on the fission product content of the UNF. Modeling the windows required field inspections and detailed examination of drawings and material specifications. Consistent with the shield testing results, MCNP results demonstrated that the shielding was very effective with respect to gamma radiation, and in addition, the analysis demonstrated that the shielding was also very effective during an accidental criticality.

Biological profile of 99mTc-HYNIC-βAla-NT(8-13) in MDAMB-231 breast cancer cell line

International Nuclear Information System (INIS)

Teodoro, Rodrigo; Faintuch, Bluma L.; Wiecek, Danielle P.; Silva, Natanael G.; Vallejo, Natalia M.

2009-01-01

Introduction: Neurotensin (NT) is a tridecapeptide involved in several growth-steps of human cancers. Recent studies postulated the role of NT and NT-receptor subtype 1 in breast cancer progression. However, the main drawback of natural NT is its rapid degradation in plasma. In an effort to develop a NT peptide-based radiopharmaceutical for the detection of breast cancer, the aim of this study was the radiolabeling of the double stabilized NT(8-13) peptide using HYNIC as chelating agent. Methods: Conjugated HYNIC-βAla-NT(8-13) was labeled with 99m Tc using tricine and EDDA as coligands. Radiochemical purity was checked by TLC and confirmed by RP-HPLC. 99m Tc-HYNIC-βAla-NT(8-13) (0.1 mL/74 MBq) was administered in Nude mice bearing MDA-MB-231 breast cancer cells and biodistribution studies were carried out at 30 and 90 min postinjection (pi). Blocking evaluation was also conducted by co-injection of 115 nmol of cold NT (8-13) analog. Planar gamma-camera imaging was acquired at the earlier time point studied. Results: Radiochemical purity of the radioconjugate was higher than 99%. Biodistribution studies revealed a very fast accumulation in tumor (1.97±0.18% ID/g, 30 min pi) with a sharply decrease at the later time point studied (0.44±0.02% ID/g). The specificity of the radioconjugate was evaluated with blockade studies. A reduction of 45.94%, 27.73% and 36.39% was found for tumor, large and small intestines, respectively, at 30 min pi. Otherwise, a less impressive blockade was observed for tumor and small intestine (28.68% and 24.90%, respectively) at the later time point studied. Conclusion: The results provide encouraging evidence in the development of radiolabeled NT(8-13) analogues for breast cancer diagnosis. (author)

Provide Views | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Reduced Fading | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

EWC Members | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Visible Transmittance | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Gas Fills | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

EWC Membership | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Reducing Condensation | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Improved Comfort | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Financing & Incentives | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Tools & Resources | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Books & Publications | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Design Considerations | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Three enzymatically active neurotoxins of Clostridium botulinum strain Af84: BoNT/A2, /F4, and /F5.

Science.gov (United States)

Kalb, Suzanne R; Baudys, Jakub; Smith, Theresa J; Smith, Leonard A; Barr, John R

2014-04-01

Botulinum neurotoxins (BoNTs) are produced by various species of clostridia and are potent neurotoxins which cause the disease botulism, by cleaving proteins needed for successful nerve transmission. There are currently seven confirmed serotypes of BoNTs, labeled A-G, and toxin-producing clostridia typically only produce one serotype of BoNT. There are a few strains (bivalent strains) which are known to produce more than one serotype of BoNT, producing either both BoNT/A and /B, BoNT/A and /F, or BoNT/B and /F, designated as Ab, Ba, Af, or Bf. Recently, it was reported that Clostridium botulinum strain Af84 has three neurotoxin gene clusters: bont/A2, bont/F4, and bont/F5. This was the first report of a clostridial organism containing more than two neurotoxin gene clusters. Using a mass spectrometry based proteomics approach, we report here that all three neurotoxins, BoNT/A2, /F4, and /F5, are produced by C. botulinum Af84. Label free MS(E) quantification of the three toxins indicated that toxin composition is 88% BoNT/A2, 1% BoNT/F4, and 11% BoNT/F5. The enzymatic activity of all three neurotoxins was assessed by examining the enzymatic activity of the neurotoxins upon peptide substrates, which mimic the toxins' natural targets, and monitoring cleavage of the substrates by mass spectrometry. We determined that all three neurotoxins are enzymatically active. This is the first report of three enzymatically active neurotoxins produced in a single strain of Clostridium botulinum.

Windows forensic analysis toolkit advanced analysis techniques for Windows 7

CERN Document Server

Carvey, Harlan

2012-01-01

Now in its third edition, Harlan Carvey has updated "Windows Forensic Analysis Toolkit" to cover Windows 7 systems. The primary focus of this edition is on analyzing Windows 7 systems and on processes using free and open-source tools. The book covers live response, file analysis, malware detection, timeline, and much more. The author presents real-life experiences from the trenches, making the material realistic and showing the why behind the how. New to this edition, the companion and toolkit materials are now hosted online. This material consists of electronic printable checklists, cheat sheets, free custom tools, and walk-through demos. This edition complements "Windows Forensic Analysis Toolkit, 2nd Edition", (ISBN: 9781597494229), which focuses primarily on XP. It includes complete coverage and examples on Windows 7 systems. It contains Lessons from the Field, Case Studies, and War Stories. It features companion online material, including electronic printable checklists, cheat sheets, free custom tools, ...

Findings relating to the use of ACPI in Windows servers; Erfahrungen in der Anwendung von ACPI bei Windows-Servern

Energy Technology Data Exchange (ETDEWEB)

Huser, A.; Grieder, T.

2004-07-01

In a practical test, the possibilities and limits of the use of energy-saving sleep modes were compiled for servers of the lower price segment. Many of these servers are used by small to medium-sized enterprises and are left running around the clock, although they are not used at night or during the week-end. The implementation of the sleep modes is based on the so-called ACPI specification (Advanced Configuration and Power Interface), which was created by an industrial consortium. The most advanced of these is the implementation for the Windows Server 2003 operating system. With Linux, the sleep modes are not yet fully available. The test was therefore carried out with the Windows Server 2003 operating system. In many applications, and in particular when the servers are used as file or web servers, no operational disadvantages result from the use of the rest states. By making use of the lowest possible sleep mode during the night and at week-ends, the energy consumption of the server can be halved. For users, the results have been summarised in a two-page fact sheet, which is enclosed with this report as an appendix. (author)

Advanced energy efficient windows

DEFF Research Database (Denmark)

Thomsen, Kirsten Engelund

2007-01-01

Windows should be paid special attention as they contribute a significant part of the total heat-loss coefficient of the building. Contrary to other parts of the thermal envelope the windows are not only heat loosers, but may gain heat in the day-time. Therefore there are possibilities for large...... energy savings. In terms of energy, windows occupy a special position compared with other thermal envelope structures due to their many functions: 1) windows let daylight into the building and provide occupants with visual contact with their surroundings 2) windows protect against the outdoor climate 3......) windows transmit solar energy that may contribute to a reduction of energy consumption, but which may also lead to unpleasant overheating. In the following paragraphs the current use of windows is reviewed with an emphasis on energy, while special products like solar protection glazing and security...

Genome sequence of a microbial lipid producing fungus Cryptococcus albidus NT2002.

Science.gov (United States)

Yong, Xiaoyu; Yan, Zhiying; Xu, Lin; Zhou, Jun; Wu, Xiayuan; Wu, Yuandong; Li, Yang; Chen, Zugeng; Zhou, Hua; Wei, Ping; Jia, Honghua

2016-04-10

Cryptococcus albidus NT2002, isolated from the soil in Xinjiang, China, appeared to have the ability to accumulate microbial lipid by utilizing various carbon sources. The predominant properties make it as a potential bio-platform for biodiesel production. Here, we report the complete genome sequence of C. albidus NT2002, which might provide a basis for further elucidation of the genetic background of this promising strain for developing metabolic engineering strategies to produce biodiesel in a green and sustainable manner. Copyright © 2016 Elsevier B.V. All rights reserved.

Design and implementation of a Windows NT network to support CNC activities

Science.gov (United States)

Shearrow, C. A.

1996-01-01

The Manufacturing, Materials, & Processes Technology Division is undergoing dramatic changes to bring it's manufacturing practices current with today's technological revolution. The Division is developing Computer Automated Design and Computer Automated Manufacturing (CAD/CAM) abilities. The development of resource tracking is underway in the form of an accounting software package called Infisy. These two efforts will bring the division into the 1980's in relationship to manufacturing processes. Computer Integrated Manufacturing (CIM) is the final phase of change to be implemented. This document is a qualitative study and application of a CIM application capable of finishing the changes necessary to bring the manufacturing practices into the 1990's. The documentation provided in this qualitative research effort includes discovery of the current status of manufacturing in the Manufacturing, Materials, & Processes Technology Division including the software, hardware, network and mode of operation. The proposed direction of research included a network design, computers to be used, software to be used, machine to computer connections, estimate a timeline for implementation, and a cost estimate. Recommendation for the division's improvement include action to be taken, software to utilize, and computer configurations.

Programming Windows Azure

CERN Document Server

Krishnan, Sriram

2010-01-01

Learn the nuts and bolts of cloud computing with Windows Azure, Microsoft's new Internet services platform. Written by a key member of the product development team, this book shows you how to build, deploy, host, and manage applications using Windows Azure's programming model and essential storage services. Chapters in Programming Windows Azure are organized to reflect the platform's buffet of services. The book's first half focuses on how to write and host application code on Windows Azure, while the second half explains all of the options you have for storing and accessing data on the plat

Windows 8 tweaks

CERN Document Server

Sinchak, Steve

2013-01-01

Acres of Windows 8 tweaks from a Microsoft MVP and creator of Tweaks.com! From a Microsoft MVP, who is also the savvy creator of Tweaks.com, comes this ultimate collection of Windows 8 workarounds. Steve Sinchak takes you way beyond default system settings, deep under the hood of Windows 8, down to the hidden gems that let you customize your Windows 8 system like you wouldn't believe. From helping you customize the appearance to setting up home networking, sharing media, and squeezing every ounce of performance out of the OS, this book delivers. Get ready to rock and roll with Wind

Involvement of neurotrophin-3 (NT-3) in the functional elimination of synaptic contacts during neuromuscular development.

Science.gov (United States)

Garcia, Neus; Santafé, Manel M; Tomàs, Marta; Lanuza, Maria A; Besalduch, Nuria; Tomàs, Josep

2010-04-05

Confocal immunohistochemistry shows that neurotrophin-3 (NT-3) and its receptor tropomyosin-related tyrosin kinase C (trkC) are present in both neonatal (P6) and adult (P45) mouse motor nerve terminals in neuromuscular junctions (NMJ) colocalized with several synaptic proteins. NT-3 incubation (1-3h, in the range 10-200ng/ml) does not change the size of the evoked and spontaneous endplate potentials at P45. However, NT-3 (1h, 100ng/ml) strongly potentiates evoked ACh release from the weak (70%) and the strong (50%) axonal inputs on dually innervated postnatal endplates (P6) but not in the most developed postnatal singly innervated synapses at P6. The present results indicate that NT-3 has a role in the developmental mechanism that eliminates redundant synapses though it cannot modulate synaptic transmission locally as the NMJ matures.

NT-proBNP is associated with coronary heart disease risk in healthy older women but fails to enhance prediction beyond established risk factors: results from the British Women's Heart and Health Study.

Science.gov (United States)

Sattar, Naveed; Welsh, Paul; Sarwar, Nadeem; Danesh, John; Di Angelantonio, Emanuele; Gudnason, Vilmundur; Davey Smith, George; Ebrahim, Shah; Lawlor, Debbie A

2010-03-01

Limited evidence suggests NT-proBNP improves prediction of coronary heart disease (CHD) events but further data are needed, especially in people without pre-existing CHD and in women. We measured NT-proBNP in serum from 162 women with incident CHD events and 1226 controls (60-79 years) in a case-control study nested within the prospective British Women's Heart and Health Study. All cases and controls were free from CHD at baseline. We related NT-proBNP to CHD event risk, and determined to what extent NT-proBNP enhanced CHD risk prediction beyond established risk factors. The odds ratio for CHD per 1 standard deviation increase in log(e)NT-proBNP was 1.37 (95% CI: 1.13-1.68) in analyses adjusted for established CHD risk factors, social class, CRP and insulin. However, addition of log(e)NT-proBNP did not improve the discrimination of a prediction model including age, social class, smoking, physical activity, lipids, fasting glucose, waist:hip ratio, hypertension, statin and aspirin use, nor a standard Framingham risk score model; area under the receiver operator curve for the former model increased from 0.676 to 0.687 on inclusion of NT-proBNP (p=0.3). Furthermore, adding NT-proBNP did not improve calibration of a prediction model containing established risk factors, nor did inclusion more appropriately re-classify participants in relation to their final outcome. Findings were similar (independent associations, but no prediction improvement) for fasting insulin and CRP. These results caution against use of NT-proBNP for CHD risk prediction in healthy women and suggest a need for larger studies in both genders to resolve outstanding uncertainties.

The plant-window system

International Nuclear Information System (INIS)

Wood, R.T.; Mullens, J.A.; Naser, J.A.

1995-01-01

Power plant data, and the information that can be derived from it, provide the link to the plant through which the operations, maintenance and engineering staff understand and manage plant performance. The increasing use of computer technology in the U.S. nuclear power industry has greatly expanded the capability to obtain, analyze, and present data about the plant to station personnel. However, it is necessary to transform the vast quantity of available data into clear, concise, and coherent information that can be readily accessed and used throughout the plant. This need can be met by an integrated computer workstation environment that provides the necessary information and software applications, in a manner that can be easily understood and used, to the proper users throughout the plant. As part of a Cooperative Research and Development Agreement with the Electric Power Research Institute, the Oak Ridge National Laboratory has developed functional requirements for a Plant-Wide Integrated Environment Distributed On Workstations (Plant-Window) System. The Plant-Window System (PWS) can serve the needs of operations, engineering, and maintenance personnel at nuclear power stations by providing integrated data and software applications (e.g., monitoring, analysis, diagnosis, and control applications) within a common environment. The PWS requirements identify functional capabilities and provide guidelines for standardized hardware, software, and display interfaces to define a flexible computer environment that permits a tailored implementation of workstation capabilities and facilitates future upgrades

Optimizing Time Windows For Managing Export Container Arrivals At Chinese Container Terminals

DEFF Research Database (Denmark)

Chen, Gang; Yang, Zhongzhen

2010-01-01

window management programme that is widely used in Chinese terminals to facilitate terminal and truck delivery operations. Firstly, the arrangement of time windows is assumed to follow the principle of minimizing transport costs. A cost function is defined that includes the costs of truck and driver...... waiting time, fuel consumption associated with truck idling, storage time of the containerized cargos and yard fee. Secondly, to minimize the total cost, a heuristic is developed based on a genetic algorithm to find a near optimal time window arrangement. The optimized solution involves the position...

Window selection for dual photopeak window scatter correction in Tc-99m imaging

International Nuclear Information System (INIS)

Vries, D.J. de; King, M.A.

1994-01-01

The width and placement of the windows for the dual photopeak window (DPW) scatter subtraction method for Tc-99m imaging is investigated in order to obtain a method that is stable on a multihead detector system for single photon emission computed tomography (SPECT) and is capable of providing a good scatter estimate for extended objects. For various window pairs, stability and noise were examined with experiments using a SPECT system, while Monte Carlo simulations were used to predict the accuracy of scatter estimates for a variety of objects and to guide the development of regression relations for various window pairs. The DPW method that resulted from this study was implemented with a symmetric 20% photopeak window composed of a 15% asymmetric photopeak window and a 5% lower window abutted at 7 keV below the peak. A power function regression was used to relate the scatter-to-total ratio to the lower window-to-total ratio at each pixel, from which an estimated scatter image was calculated. DPW demonstrated good stability, achieved by abutting the two windows away from the peak. Performance was assessed and compared with Compton window subtraction (CWS). For simulated extended objects, DPW generally produced a less biased scatter estimate than the commonly used CWS method with k = 0.5. In acquisitions of a clinical SPECT phantom, contrast recovery was comparable for both DPW and CWS; however, DPW showed greater visual contrast in clinical SPECT bone studies

Windows Terminal Servers Orchestration

Science.gov (United States)

Bukowiec, Sebastian; Gaspar, Ricardo; Smith, Tim

2017-10-01

Windows Terminal Servers provide application gateways for various parts of the CERN accelerator complex, used by hundreds of CERN users every day. The combination of new tools such as Puppet, HAProxy and Microsoft System Center suite enable automation of provisioning workflows to provide a terminal server infrastructure that can scale up and down in an automated manner. The orchestration does not only reduce the time and effort necessary to deploy new instances, but also facilitates operations such as patching, analysis and recreation of compromised nodes as well as catering for workload peaks.

Increased NT-pro-B-type natriuretic peptide independently predicts outcome following catheter ablation of atrial fibrillation

DEFF Research Database (Denmark)

Nilsson, Brian; Goetze, Jens Peter; Chen, Xu

2009-01-01

AIMS: To investigate whether NT-proBNP before ablation treatment and after exercise testing has predictive information regarding the clinical outcome following pulmonary vein isolation in patients with atrial fibrillation (AF). METHODS: NT-proBNP analysis were obtained before the ablation (before...

Gamma-Ray Spectrum Analysis Software GDA

International Nuclear Information System (INIS)

Wanabongse, P.

1998-01-01

The developmental work on computer software for gamma-ray spectrum analysis has been completed as a software package version 1.02 named GDA, which is an acronym for Gamma-spectrum Deconvolution and Analysis. The software package consists of three 3.5-inch diskettes for setup and a user's manual. GDA software can be installed for using on a personal computer with Windows 95 or Windows NT 4.0 operating system. A computer maybe the type of 80486 CPU with 8 megabytes of memory

Prenatal Clinical Assessment of NT-proBNP as a Diagnostic Tool for Preeclampsia, Gestational Hypertension and Gestational Diabetes Mellitus.

Directory of Open Access Journals (Sweden)

Pawel Sadlecki

Full Text Available Common complications of pregnancy include preeclampsia (PE, gestational hypertension (GH and gestational diabetes mellitus (GDM. Hypertensive disorders (PE/GH and GDM may result in greater maternal, fetal and neonatal morbidity and mortality. Women with PE/GH, one of the most common causes of heart burden in an obstetrical setting, present with elevated serum levels of BNP and NT-proBNP. The aim of this study was to shed more light on the role of NT-proBNP in pathophysiology of PE, GH and GDM. The study included 156 pregnant women with singleton pregnancies. A total of 26 women developed arterial hypertension during pregnancy, 14 were diagnosed with PE, and GDM was detected in 81 patients. The control group included 35 women with uncomplicated pregnancies, normal arterial blood pressure and normal glucose concentrations. Patients with GH presented with significantly higher serum concentrations of NT-proBNPthan normotensive women (65.5 vs. 37.4 pg/ml; p = 0.0136. Serum levels of NT-proBNP in patients with PE were the highest of all the analyzed subsets, being significantly higher than in women without this condition (89.00 vs. 37.4pg/ml,p = 0,0136. However, women with and without GDM did not differ significantly in terms of their serum NT-proBNPconcentrations. Serum NT-proBNP (pg/ml (p = 0.0001 and BMI (p<0.0001 turned out to be independent predictors of GH on multivariate logistic regression analysis.Moreover, serum NT-proBNP (pg/ml was identified as an independent indicator of PE (p = 0.0016. A significant inverse correlation was found between birth weight and maternal serum NT-proBNP concentrations. In our opinion, NT-proBNP can be a useful clinical marker of GH and PE. Determination of NT-proBNP levels may be helpful in identification of patients with PE and GH and in their qualification for intensive treatment; this in turn, may be reflected by better neonatal outcomes.

Thin, X-ray-Transparent Windows for Imaging Applications with a Pneumatically Pressurized Enclosure

International Nuclear Information System (INIS)

Shu Deming; Wang Jin; Preissner, Curt

2007-01-01

We have developed a novel thin, x-ray-transparent window system for environmental chambers involving pneumatic pressures above 10 bar. The windows allow for x-ray access to fuel sprays injected into a pressurized chamber that mimics realistic internal combustion engine cylinder operating conditions. The design of the window system and its experimental test results are presented in this paper, as well as its further development for in situ x-ray imaging applications in a high-pressure and high-temperature environment

The predictive value of plasma biomarkers in discharged heart failure patients: role of plasma NT-proBNP.

Science.gov (United States)

Leto, Laura; Testa, Marzia; Feola, Mauro

2016-04-01

Natriuretic peptides (NPs) have demonstrated their value to support clinical diagnosis of heart failure (HF); furthermore they are also studied for their prognostic role using them to guide appropriate management strategies. The present review gathers available evidence on prognostic role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients hospitalized for acute decompensated heart failure (ADHF). We searched Medline for English-language studies with the sequent key-words: "acute heart failure/acute decompensated heart failure", "NT-proBNP/N-terminal pro-B type natriuretic peptide" and "prognosis/mortality/readmission". Almost 30 studies were included. NT-proBNP plasma levels at admission are strongly associated with all-cause short-term mortality (2-3 months), mid-term (6-11 months) or long- term mortality (more than one year) of follow-up. Regarding the prognostic power on cardiac death fewer data are available with uncertain results. NT-proBNP at discharge demonstrated its prognostic role for all-cause mortality at mid and long-term follow-up. The relation between NT-proBNP at discharge and cardiovascular mortality or composite end-point is under investigation. A decrease in NT-proBNP values during hospitalization provided prognostic prospects mainly for cardiovascular mortality and HF readmission. A 30% variation in NT-proBNP levels during in-hospital stay seemed to be an optimal cut-off for prognostic role. SNT-proBNP plasma levels proved to have a strong correlation with all-cause mortality, cardiovascular mortality, morbidity and composite outcomes in patients discharged after an ADHF. A better definition of the correct time of serial measurements and the cut-off values might be the challenge for the future investigations.

Extremely intense (SML ≤–2500 nT substorms: isolated events that are externally triggered?

Directory of Open Access Journals (Sweden)

B. T. Tsurutani

2015-05-01

Full Text Available We examine particularly intense substorms (SML ≤–2500 nT, hereafter called "supersubstorms" or SSS events, to identify their nature and their magnetic storm dependences. It is found that these intense substorms are typically isolated events and are only loosely related to magnetic storms. SSS events can occur during super (Dst ≤–250 nT and intense (−100 nT ≥ Dst >–250 magnetic storms. SSS events can also occur during nonstorm (Dst ≥–50 nT intervals. SSSs are important because the strongest ionospheric currents will flow during these events, potentially causing power outages on Earth. Several SSS examples are shown. SSS events appear to be externally triggered by small regions of very high density (~30 to 50 cm−3 solar wind plasma parcels (PPs impinging upon the magnetosphere. Precursor southward interplanetary magnetic fields are detected prior to the PPs hitting the magnetosphere. Our hypothesis is that these southward fields input energy into the magnetosphere/magnetotail and the PPs trigger the release of the stored energy.

Biological profile of {sup 99m}Tc-HYNIC-betaAla-NT(8-13) in MDAMB-231 breast cancer cell line

Energy Technology Data Exchange (ETDEWEB)

Teodoro, Rodrigo; Faintuch, Bluma L.; Wiecek, Danielle P.; Silva, Natanael G.; Vallejo, Natalia M., E-mail: teodoro_rodrigo@yahoo.com.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil). Diretoria de Radiofarmacia

2009-07-01

Introduction: Neurotensin (NT) is a tridecapeptide involved in several growth-steps of human cancers. Recent studies postulated the role of NT and NT-receptor subtype 1 in breast cancer progression. However, the main drawback of natural NT is its rapid degradation in plasma. In an effort to develop a NT peptide-based radiopharmaceutical for the detection of breast cancer, the aim of this study was the radiolabeling of the double stabilized NT(8-13) peptide using HYNIC as chelating agent. Methods: Conjugated HYNIC-betaAla-NT(8-13) was labeled with {sup 99m}Tc using tricine and EDDA as coligands. Radiochemical purity was checked by TLC and confirmed by RP-HPLC. {sup 99m}Tc-HYNIC-betaAla-NT(8-13) (0.1 mL/74 MBq) was administered in Nude mice bearing MDA-MB-231 breast cancer cells and biodistribution studies were carried out at 30 and 90 min postinjection (pi). Blocking evaluation was also conducted by co-injection of 115 nmol of cold NT (8-13) analog. Planar gamma-camera imaging was acquired at the earlier time point studied. Results: Radiochemical purity of the radioconjugate was higher than 99%. Biodistribution studies revealed a very fast accumulation in tumor (1.97+-0.18% ID/g, 30 min pi) with a sharply decrease at the later time point studied (0.44+-0.02% ID/g). The specificity of the radioconjugate was evaluated with blockade studies. A reduction of 45.94%, 27.73% and 36.39% was found for tumor, large and small intestines, respectively, at 30 min pi. Otherwise, a less impressive blockade was observed for tumor and small intestine (28.68% and 24.90%, respectively) at the later time point studied. Conclusion: The results provide encouraging evidence in the development of radiolabeled NT(8-13) analogues for breast cancer diagnosis. (author)

49 CFR 238.113 - Emergency window exits.

Science.gov (United States)

2010-10-01

..., electrical locker, or kitchen); and (B) There are no more than eight seats in the seating area. (4) Cars with...), a bathroom, kitchen, or locomotive cab is not considered a “compartment.” (b) Ease of operability. On or after November 8, 1999, each emergency window exit shall be designed to permit rapid and easy...

CLC-Nt1, a putative chloride channel protein of tobacco, co-localizes with mitochondrial membrane markers.

Science.gov (United States)

Lurin, C; Güclü, J; Cheniclet, C; Carde, J P; Barbier-Brygoo, H; Maurel, C

2000-06-01

The voltage-dependent chloride channel (CLC) family of membrane proteins has cognates in animals, yeast, bacteria and plants, and chloride-channel activity has been assigned to most of the animal homologues. Lack of evidence of CLC functions in plants prompted us to characterize the cellular localization of the tobacco CLC-Nt1 protein. Specific polyclonal antibodies were raised against an N-terminal polypeptide of CLC-Nt1. These antibodies were used to probe membrane proteins prepared by various cell-fractionation methods. These included aqueous two-phase partitioning (for plasma membranes), free-flow electrophoresis (for vacuolar and plasma membranes), intact vacuole isolation, Percoll-gradient centrifugation (for plastids and mitochondria) and stepped, linear, sucrose-density-gradient centrifugation (for mitochondria). Each purified membrane fraction was characterized with specific marker enzyme activities or antibodies. Our studies ruled out the possibility that the major cell localization of CLC-Nt1 was the vacuolar or plasma membranes, the endoplasmic reticulum, the Golgi apparatus or the plastids. In contrast, we showed that the tobacco CLC-Nt1 specifically co-localized with the markers of the mitochondrial inner membrane, cytochrome c oxidase and NAD9 protein. CLC-Nt1 may correspond to the inner membrane anion channel ('IMAC') described previously in animal and plant mitochondria.

GLI1 is involved in cell cycle regulation and proliferation of NT2 embryonal carcinoma stem cells

DEFF Research Database (Denmark)

Vestergaard, Janni; Lind-Thomsen, Allan; Pedersen, Mikkel W.

2008-01-01

of altered HH signaling are interpreted by specific cell types. We have investigated the role of the HH transcription factor glioma-associated oncogene homolog 1 (GLI1) in the human Ntera2=D1 (NT2) embryonal carcinoma stem cell line. The study revealed that expression of GLI1 and its direct transcriptional......1 phase cyclins. In conclusion, our results suggest that GLI1 is involved in cell cycle and proliferation control in the embryonal carcinoma stem cell line NT2....... target Patched (PTCH) is downregulated in the early stages of retinoic acid-induced neuronal differentiation of NT2 cells. To identify transcriptional targets of the HH transcription factor GLI1 in NT2 cells, we performed global expression profiling following GLI1 RNA interference (RNAi). Of the similar...

NT-proBNP in unstable coronary artery disease--experiences from the FAST, GUSTO IV and FRISC II trials.

Science.gov (United States)

Jernberg, Tomas; James, Stefan; Lindahl, Bertil; Stridsberg, Mats; Venge, Per; Wallentin, Lars

2004-03-15

Risk stratification is important in patients with unstable coronary artery disease (CAD), i.e. unstable angina or non-ST-elevation myocardial infarction. This article focuses on the emerging role of N-terminal pro brain natriuretic peptide (NT-proBNP) and the results from the FAST, GUSTO IV and FRISC II trials. In the FAST study, NT-proBNP was measured on admission in 755 patients admitted because of symptoms suggestive of unstable CAD. Follow up was performed after 40 months. The GUSTO IV and the FRISC II-trials included patients with unstable CAD and NT-proBNP was analyzed in 6806 and 2019 patients, with follow up after 1 and 2 years, respectively. In the FAST study, patients in the 2nd, 3rd, and 4th NT-proBNP quartile had a relative risk of subsequent death of 4.2 (1.6-11.1), 10.7 (4.2-26.8) and 26.6 (10.8-65.5), respectively. In the GUSTO IV trial, increasing quartiles of NT-proBNP were related to short and long term mortality which at 1 year was; 1.8%, 3.9%, 7.7% and 19.2% (P<0.001), respectively. In multivariable analyses including well-known predictors of outcome, NT-proBNP level was independently associated to mortality in all three studies. In the FRISC II trial, the NT-proBNP level, especially if combined with a marker of inflammation, identified those with the greatest benefit from an early invasive strategy. NT-proBNP is strongly associated with mortality in patients with suspected or confirmed unstable CAD and, combined with a marker of inflammation, seems helpful in identifying those with greatest benefit from an early invasive strategy.

NT-proBNP, echocardiographic abnormalities and subclinical coronary artery disease in high risk type 2 diabetic patients

DEFF Research Database (Denmark)

Reinhard, Henrik; Hansen, Peter R; Wiinberg, Niels

2012-01-01

-NT-proBNP and the putative residual abnormalities in such patients are not well described. This study examined echocardiographic measurements of LV hypertrophy, atrial dilatation and LV dysfunction and their relation to P-NT-proBNP levels or subclinical coronary artery disease (CAD) in type 2 diabetic patients......Intensive multifactorial treatment aimed at prevention of cardiovascular (CV) disease may reduce left ventricular (LV) echocardiographic abnormalities in diabetic subjects. Plasma N-terminal (NT)-proBNP predicts CV mortality in diabetic patients but the association between P...

Upgrade of RMS computers for Y2K problems in RX and related building of HANARO

International Nuclear Information System (INIS)

Kim, Jung Taek; Kim, J. T.; Ham, C. S.; Kim, C. H.; Lee, Bong Jae; Jae, Yoo Kyung

2000-08-01

The Objectives of this Project are as follows : - To resolve the problems of Y2k and operation and maintenance of RMS Computers in RX and related Building of HANARO - To upgrade 486 PC to Pentium II PC - To make Windows NT-Based platform for aspects of user - To make an information structure for radiation using ireless and network devices The Contents of the Project are as follows : - To make Windows NT-Based platform for Radiation Monitoring System - To make Software Platform and Environment for the developing the application program - To design and implement Database Structure - To implement RS232c communication program between local indicators and scanning computers - To implement IEEE 802.3 ethernet communication program between scanning computers and RMTs - To implement user interface for radiation monitoring - To test and inspect Y2k problems

Upgrade of RMS computers for Y2K problems in RX and related building of HANARO

Energy Technology Data Exchange (ETDEWEB)

Kim, Jung Taek; Kim, J. T.; Ham, C. S.; Kim, C. H.; Lee, Bong Jae; Jae, Yoo Kyung

2000-08-01

The Objectives of this Project are as follows : - To resolve the problems of Y2k and operation and maintenance of RMS Computers in RX and related Building of HANARO - To upgrade 486 PC to Pentium II PC - To make Windows NT-Based platform for aspects of user - To make an information structure for radiation using ireless and network devices The Contents of the Project are as follows : - To make Windows NT-Based platform for Radiation Monitoring System - To make Software Platform and Environment for the developing the application program - To design and implement Database Structure - To implement RS232c communication program between local indicators and scanning computers - To implement IEEE 802.3 ethernet communication program between scanning computers and RMTs - To implement user interface for radiation monitoring - To test and inspect Y2k problems.

Schools Facing the Expiration of Windows XP

Science.gov (United States)

Cavanagh, Sean

2013-01-01

Microsoft's plans to end support for Windows XP, believed to be the dominant computer operating system in K-12 education, could pose big technological and financial challenges for districts nationwide--issues that many school systems have yet to confront. The giant software company has made it clear for years that it plans to stop supporting XP…

Thermal bridges of modern windows

DEFF Research Database (Denmark)

Hansen, Ernst Jan de Place; Møller, Eva B.; Nielsen, Anker

2013-01-01

if the window has an U-factor of 1 W/(m2·K) or lower. This paper describes the development of modern, energy efficient Danish windows with reduced thermal bridges. It focuses on materials, geometry, and sealing of window panes based on a literature review. Examples of modern windows are presented. Experience...... been an important driver for the development of new window solutions in Denmark, increasing the inner-surface temperature at the sealing of window panes. However, it will not stop complaints fromconsumers, as this temperature is calculated under standardized conditions. Increasing requirements...

NT Logistika kitsaskohast sai ettevõttele trump / Elo Odres

Index Scriptorium Estoniae

Odres, Elo, 1969-

2007-01-01

NT Logistika pälvis kõige pere- ja töötajasõbralikuma ettevõtte tiitli. Vt. samas: Edetabel: Töötajasõbralike TOP; Peresõbralike TOP; Massaaž tuleb firmasse kätte; Suurfirmadel raske konkureerida; Töötajate lastest võrsub järelkasv; Tasuta lõunad on olemas

Electrochromic Windows: Advanced Processing Technology

Energy Technology Data Exchange (ETDEWEB)

SAGE Electrochromics, Inc

2006-12-13

This project addresses the development of advanced fabrication capabilities for energy saving electrochromic (EC) windows. SAGE EC windows consist of an inorganic stack of thin films deposited onto a glass substrate. The window tint can be reversibly changed by the application of a low power dc voltage. This property can be used to modulate the amount of light and heat entering buildings (or vehicles) through the glazings. By judicious management of this so-called solar heat gain, it is possible to derive significant energy savings due to reductions in heating lighting, and air conditioning (HVAC). Several areas of SAGE’s production were targeted during this project to allow significant improvements to processing throughput, yield and overall quality of the processing, in an effort to reduce the cost and thereby improve the market penetration. First, the overall thin film process was optimized to allow a more robust set of operating points to be used, thereby maximizing the yield due to the thin film deposition themselves. Other significant efforts aimed at improving yield were relating to implementing new procedures and processes for the manufacturing process, to improve the quality of the substrate preparation, and the quality of the IGU fabrication. Furthermore, methods for reworking defective devices were developed, to enable devices which would otherwise be scrapped to be made into useful product. This involved the in-house development of some customized equipment. Finally, the improvements made during this project were validated to ensure that they did not impact the exceptional durability of the SageGlass® products. Given conservative estimates for cost and market penetration, energy savings due to EC windows in residences in the US are calculated to be of the order 0.026 quad (0.026×1015BTU/yr) by the year 2017.

NASA Glenn Steady-State Heat Pipe Code GLENHP: Compilation for 64- and 32-Bit Windows Platforms

Science.gov (United States)

Tower, Leonard K.; Geng, Steven M.

2016-01-01

A new version of the NASA Glenn Steady State Heat Pipe Code, designated "GLENHP," is introduced here. This represents an update to the disk operating system (DOS) version LERCHP reported in NASA/TM-2000-209807. The new code operates on 32- and 64-bit Windows-based platforms from within the 32-bit command prompt window. An additional evaporator boundary condition and other features are provided.

Handbook on Windows and Energy

DEFF Research Database (Denmark)

Thomsen, Kirsten Engelund; Schultz, Jørgen Munthe; Svendsen, Sv Aa Højgaard

The handbook on windows and energy is a general description of windows with the main focus put on the energy performance. Common window products are described by commonly used nomenclature, description of frame and sash conctructions and description of commonly used glazing types.The energy...... transmission through windows is described in detail including radiation, convection and conduction as well as solar transmittance of window glazing. The most used terms related to characterization of window energy performance are defined and calculation methods according to international standards...... flow and detailed calculation of light and solar transmittance is given.Different measurement techniques for characterization of window heat loss coefficient and total solar energy transmittance is described and references to interantional standards are given.Finally, the handbook includes...

NT10: recent advances in carbon nanotube science and applications.

Science.gov (United States)

Dresselhaus, Mildred S

2010-08-24

A review of recent advances in carbon nanotube science and applications is presented in terms of what was learned at the NT10 11th International Conference on the Science and Application of Nanotubes held in Montreal, Canada, June 29-July 2, 2010.

High power tests of beryllium oxide windows to the lower hybrid current drive launcher in JET

International Nuclear Information System (INIS)

Ekedahl, A.; Brandon, M.; Finburg, P.

1999-01-01

The vacuum windows to the 3.70 GHz Lower Hybrid Current Drive (LHCD) system in JET were originally designed to withstand 350 kW for 20 s with VSWR ≤ 1.8. High power RF tests of the windows have been carried out in the LHCD test facility at JET. All windows that were tested could operate at 500 kW for 10 s in a matched load. Two windows passed an endurance test at 250 kW for 20 s with the windows terminated in a short circuit. One window also passed this endurance test without active cooling. The results show that this type of window can be used in a new advanced launcher, as proposed for ITER, in which the output power from each klystron (P ≤ 500 kW) will be transmitted through one waveguide and one vacuum window. (author)

Impact of underlying heart disease per se on the utility of preoperative NT-proBNP in adult cardiac surgery.

Directory of Open Access Journals (Sweden)

Huiqi Jiang

Full Text Available The primary aim was to investigate the role of underlying heart disease on preoperative NT-proBNP levels in patients admitted for adult cardiac surgery, after adjusting for the known confounders age, gender, obesity and renal function. The second aim was to investigate the predictive value of preoperative NT-proBNP with regard to severe postoperative heart failure (SPHF and postoperative mortality.A retrospective cohort study based on preoperative NT-proBNP measurements in an unselected cohort including all patients undergoing first time surgery for coronary artery disease (CAD; n = 2226, aortic stenosis (AS; n = 406 or mitral regurgitation (MR; n = 346 from April 2010 to August 2016 in the southeast region of Sweden (n = 2978. Concomitant procedures were not included, with the exception of Maze or tricuspid valve procedures.Preoperative NT-proBNP was 1.67 times (p<0.0001 and 1.41 times (p<0.0001 higher in patients with AS or MR respectively, than in patients with CAD after adjusting for confounders. NT-proBNP demonstrated significant discrimination with regard to SPHF in CAD (AUC = 0.79, 95%CI 0.73-0.85, p<0.0001, MR (AUC = 0.80, 95%CI 0.72-0.87, p<0.0001 and AS (AUC = 0.66, 95%CI 0.51-0.81, p = 0.047. In CAD patients NT-proBNP demonstrated significant discrimination with regard to postoperative 30-day or in-hospital mortality (AUC = 0.78; 95%CI 0.71-0.85, p<0.0001. The number of deaths was too few in the AS and MR group to permit analysis. Elevated NT-proBNP emerged as an independent risk factor for SPHF, and postoperative mortality in CAD.Patients with AS or MR have higher preoperative NT-proBNP than CAD patients even after adjusting for confounders. The predictive value of NT-proBNP with regard to SPHF was confirmed in CAD and MR patients but was less convincing in AS patients.

Lower HVAC Costs | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Increased Light & View | Efficient Windows Collaborative

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Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Condensation Resistance (CR) | Efficient Windows Collaborative

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Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Fact Sheets & Publications | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

State Fact Sheets | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

State Code Guides | Efficient Windows Collaborative

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Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Low Conductance Spacers | Efficient Windows Collaborative

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Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Energy & Cost Savings | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Provide Natural Light | Efficient Windows Collaborative

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Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Provide Fresh Air | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Air Leakage (AL) | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Windows 95 Beslutningsguide

DEFF Research Database (Denmark)

Sørensen, Jens Otto

1996-01-01

Mange virksomheder der bruger pc'er står netop nu over for valget: Skal vi fortsætte med DOS/Windows 3.x som operativsystem, eller skal vi skifte til efterfølgeren Windows 95? Skal vi/kan vi skifte successivt, eller skal det være en "alt eller intet beslutning". Hvornår er det rigtige tidspunkt...... at skifte? Denne artikel vil forsøge at give en baggrundsviden om Windows 95, der kan hjælpe virksomhederne igennem denne beslutningsfase....

Gabor windows supported on [-1,1] and compactly supported dual windows

DEFF Research Database (Denmark)

Christensen, Ole; Kim, H. O.; Rae Young, Kim

2010-01-01

window. More precisely, we show that if b window supported on [-N, N]. Under the additional assumption that g is continuous and only has a finite number of zeros on inverted left perpendicular-1, 1inverted right perpendicular, we...... characterize the frame property of {E(mb)T(n)g}(m,n is an element of Z). As a consequence we obtain easily verifiable criteria for a function g to generate a Gabor frame with a dual window having compact support of prescribed size....

A relational database for physical data from TJ-II discharges

International Nuclear Information System (INIS)

Sanchez, E.; Portas, A.B.; Vega, J.

2002-01-01

A relational database (RDB) has been developed for classifying TJ-II experimental data according to physical criteria. Two objectives have been achieved: the design and the implementation of the database and the software tools for data access depending on a single software driver. TJ-II data were arranged in several tables with a flexible design, speedy performance, efficient search capacity and adaptability to meet present and future, requirements. The software has been developed to allow the access to the TJ-II RDB from a variety of computer platforms (ALPHA AXP/True64 UNIX, CRAY/UNICOS, Intel Linux, Sparc/Solaris and Intel/Windows 95/98/NT) and programming languages (FORTRAN and C/C++). The database resides in a Windows NT Server computer and is managed by Microsoft SQL Server. The access software is based on open network computing remote procedure call and follows client/server model. A server program running in the Windows NT computer controls data access. Operations on the database (through a local ODBC connection) are performed according to predefined permission protocols. A client library providing a set of basic functions for data integration and retrieval has been built in both static and dynamic link versions. The dynamic version is essential in accessing RDB data from 4GL environments (IDL and PV-WAVE among others)

Designing for Windows 8 fundamentals of great design in Windows Store apps

CERN Document Server

Schooley, Brent

2013-01-01

Designing for Windows 8 is a fast-paced, 150-page primer on the key design concepts you need to create successful Windows 8 apps. This book will help you design a user interface that is both delightful and effective, feels 'right' to your users, and encapsulates a great Windows 8 experience. In this book, you will: Meet the building blocks of solid Windows 8 UI design in a well-designed sample app. Learn how to incorporate key design elements into your apps, such as the app bar, charms and subtle animations from the animation library. Find out how to deliver the core experience that your users

NT-proBNP levels, atherosclerosis and vascular function in asymptomatic type 2 diabetic patients with microalbuminuria: peripheral reactive hyperaemia index but not NT-proBNP is an independent predictor of coronary atherosclerosis

DEFF Research Database (Denmark)

Reinhard, Henrik; Wiinberg, Niels; Hansen, Peter R

2011-01-01

for atherosclerosis is unclear. We examined the interrelationship between P-NT-proBNP, presence of atherosclerosis and/or vascular dysfunction in the coronary, carotid and peripheral arteries in asymptomatic type 2 diabetic patients with microalbuminuria that received intensive multifactorial treatment. METHODS...... AND RESULTS: P-NT-proBNP was measured in 200 asymptomatic type 2 patients without known cardiac disease that received intensive multifactorial treatment for CV risk reduction. Patients were examined for coronary, carotid and peripheral atherosclerosis, as defined by coronary calcium score=400, carotid intima...

Systematics of (n,t) reactions in medium and heavy mass nuclei at 14.6 MeV

International Nuclear Information System (INIS)

Woo, T.T.

1979-01-01

The production cross sections for (n,t) reactions of 14.6-MeV neutrons with isotopes of the natural elements Ca, Ti, Cr, Fe, Ni, Y, Mo, Pd, Cd, Sn, Pb, La, and with the enriched isotopes 86 Sr, 114 Cd, 130 Te, 205 Tl were measured by the activation technique using high-energy resolution gamma-ray spectrometry. The systematics for the (n,t) reactions were investigated as a function of the relative neutron excess. The experimentally determined values of the cross sections are in good agreement with values calculated by an empirical equation. The cross section ratios (n,t) and (n,p) reactions were calculated on the basis of the statistical model

Plasma NT-proBNP mirrors the deleterious cardiovascular and renal continuum in hypertension.

Science.gov (United States)

Courand, Pierre-Yves; Harbaoui, Brahim; Bècle, Clément; Mouly-Bertin, Carine; Lantelme, Pierre

2017-03-01

Background The aims of this study were (a) to test the ability of N-terminal pro-brain natriuretic peptide (NT-proBNP) to detect subclinical target organ damage (TOD) denoted by left ventricular hypertrophy (LVH), aortic stiffness or renal damage and (b) to test its reproducibility in two different conditions in an ancillary study. Methods The study included 837 patients (50.9% men) with hypertension aged 50 ± 24 years with a median 24-h ambulatory blood pressure (BP) of 148/90 mmHg. LVH was assessed by transthoracic echocardiography and echocardiography, aortic stiffness was assessed by carotid-femoral pulse wave (PWV) measurements and renal dysfunction by measurements of the estimated glomerular filtration rate (eGFR) and microalbuminuria. Results After the exclusion of patients with a history of heart failure, NT-proBNP was independently correlated with sex, systolic BP, primary hypertension, PWV, LVH and eGFR, but not with microalbuminuria. The median (interquartile range) NT-proBNP increased gradually according to the number of target organs damaged: 42 (24-70), 77 (39-151), 141 (81-250) and 334 (177-556) pg/mL, for damage to 0, 1, 2 and 3 target organs, respectively ( p secondary hypertension. A threshold at 90 pg/mL for men and 142 pg/mL in women had a specificity of 95% to detect at least one TOD (areas under ROC curve 0.790 and 0.783, respectively). The reproducibility of NT-proBNP was fairly good in this setting ( r = 0.952, p hypertension.

Simulated annealing (SA to vehicle routing problems with soft time windows

Directory of Open Access Journals (Sweden)

Suphan Sodsoon

2014-12-01

Full Text Available The researcher has applied and develops the meta-heuristics method to solve Vehicle Routing Problems with Soft Time Windows (VRPSTW. For this case there was only one depot, multi customers which each generally sparse either or demand was different though perceived number of demand and specific period of time to receive them. The Operation Research was representative combinatorial optimization problems and is known to be NP-hard. In this research algorithm, use Simulated Annealing (SA to determine the optimum solutions which rapidly time solving. After developed the algorithms, apply them to examine the factors and the optimum extended time windows and test these factors with vehicle problem routing under specific time windows by Solomon in OR-Library in case of maximum 25 customers. Meanwhile, 6 problems are including of C101, C102, R101, R102, RC101 and RC102 respectively. The result shows the optimum extended time windows at level of 50%. At last, after comparison these answers with the case of vehicle problem routing under specific time windows and flexible time windows, found that percentage errors on number of vehicles approximately by -28.57% and percentage errors on distances approximately by -28.57% which this algorithm spent average processing time on 45.5 sec/problems.

NT-proBNP is associated with fibulin-1 in Africans

DEFF Research Database (Denmark)

Kruger, R; Schutte, R; Huisman, H W

2012-01-01

, expressed in elastin-containing fibres of blood vessels, and also in the heart. Due to an alarming prevalence of hypertensive heart disease in black South Africans, we investigated the associations of NT-proBNP with fibulin-1 and markers of arterial stiffness in Africans and Caucasians....

Windows with improved energy performances

DEFF Research Database (Denmark)

Laustsen, Jacob Birck; Svendsen, Svend

2003-01-01

Heat loss through windows represents a considerable part of the total heat loss from houses. However, apart from providing daylight access and view, windows offer a unique potential for solar gain to be exploited during the heating season. Until now valuation of the energy performance of windows...... has primary focused on the heat loss coefficient, U-value. However, as the U-value, especially for the glazing part, has improved considerably during the last years, the total solar energy transmittance, g-value, has become equally important to the total energy performance of windows. Improved energy...... resulted in a window with a positive net energy gain (in short the Net Gain Window), which means that it contributes to the space heating of the building. All improvements are based on existing technology and manufacturing methods. The results from this work show that the energy performances of windows can...

Visual merchandising window display

Directory of Open Access Journals (Sweden)

Opris (Cas. Stanila M.

2013-12-01

Full Text Available Window display plays a major part in the selling strategies; it does not only include the simple display of goods, nowadays it is a form of art, also having the purpose of sustaining the brand image. This article wants to reveal the tools that are essential in creating a fabulous window display. Being a window designer is not an easy job, you have to always think ahead trends, to have a sense of colour, to know how to use light to attract customers in the store after only one glance at the window. The big store window displays are theatre scenes: with expensive backgrounds, special effects and high fashion mannequins. The final role of the displays is to convince customers to enter the store and trigger the purchasing act which is the final goal of the retail activity.

Music@Microsoft.Windows: Composing Ambience

Science.gov (United States)

Rickert, Thomas

2010-01-01

It is well known, of course, that all Windows versions except for 3.1 have a brief (four to six second) piece of music indicating that Windows is booted and ready for use. While the music may indicate Windows has booted, it bears no immediately discernable relation to the various uses we might actually put Windows to--working, gaming,…

Windows Instant Messaging App Forensics: Facebook and Skype as Case Studies

Science.gov (United States)

Yang, Teing Yee; Dehghantanha, Ali; Choo, Kim-Kwang Raymond; Muda, Zaiton

2016-01-01

Instant messaging (IM) has changed the way people communicate with each other. However, the interactive and instant nature of these applications (apps) made them an attractive choice for malicious cyber activities such as phishing. The forensic examination of IM apps for modern Windows 8.1 (or later) has been largely unexplored, as the platform is relatively new. In this paper, we seek to determine the data remnants from the use of two popular Windows Store application software for instant messaging, namely Facebook and Skype on a Windows 8.1 client machine. This research contributes to an in-depth understanding of the types of terrestrial artefacts that are likely to remain after the use of instant messaging services and application software on a contemporary Windows operating system. Potential artefacts detected during the research include data relating to the installation or uninstallation of the instant messaging application software, log-in and log-off information, contact lists, conversations, and transferred files. PMID:26982207

Windows Instant Messaging App Forensics: Facebook and Skype as Case Studies.

Science.gov (United States)

Yang, Teing Yee; Dehghantanha, Ali; Choo, Kim-Kwang Raymond; Muda, Zaiton

2016-01-01

Instant messaging (IM) has changed the way people communicate with each other. However, the interactive and instant nature of these applications (apps) made them an attractive choice for malicious cyber activities such as phishing. The forensic examination of IM apps for modern Windows 8.1 (or later) has been largely unexplored, as the platform is relatively new. In this paper, we seek to determine the data remnants from the use of two popular Windows Store application software for instant messaging, namely Facebook and Skype on a Windows 8.1 client machine. This research contributes to an in-depth understanding of the types of terrestrial artefacts that are likely to remain after the use of instant messaging services and application software on a contemporary Windows operating system. Potential artefacts detected during the research include data relating to the installation or uninstallation of the instant messaging application software, log-in and log-off information, contact lists, conversations, and transferred files.

Windows Instant Messaging App Forensics: Facebook and Skype as Case Studies.

Directory of Open Access Journals (Sweden)

Teing Yee Yang

Full Text Available Instant messaging (IM has changed the way people communicate with each other. However, the interactive and instant nature of these applications (apps made them an attractive choice for malicious cyber activities such as phishing. The forensic examination of IM apps for modern Windows 8.1 (or later has been largely unexplored, as the platform is relatively new. In this paper, we seek to determine the data remnants from the use of two popular Windows Store application software for instant messaging, namely Facebook and Skype on a Windows 8.1 client machine. This research contributes to an in-depth understanding of the types of terrestrial artefacts that are likely to remain after the use of instant messaging services and application software on a contemporary Windows operating system. Potential artefacts detected during the research include data relating to the installation or uninstallation of the instant messaging application software, log-in and log-off information, contact lists, conversations, and transferred files.

The association between disease activity and NT-proBNP in 238 patients with rheumatoid arthritis: a 10-year longitudinal study

Science.gov (United States)

Provan, Sella A; Angel, Kristin; Ødegård, Sigrid; Mowinckel, Petter; Atar, Dan; Kvien, Tore K

2008-01-01

Introduction Disease activity in patients with rheumatoid arthritis (RA) is associated with increased cardiovascular morbidity and mortality, of which N-terminal pro-brain natriuretic peptide (NT-proBNP) is a predictor. Our objective was to examine the cross-sectional and longitudinal associations between markers of inflammation, measures of RA disease activity, medication used in the treatment of RA, and NT-proBNP levels (dependent variable). Methods Two hundred thirty-eight patients with RA of less than 4 years in duration were followed longitudinally with three comprehensive assessments of clinical and radiographic data over a 10-year period. Serum samples were frozen and later batch-analyzed for NT-proBNP levels and other biomarkers. Bivariate, multivariate, and repeated analyses were performed. Results C-reactive protein (CRP) levels at baseline were cross-sectionally associated with NT-proBNP levels after adjustment for age and gender (r2 adjusted = 0.23; P < 0.05). At the 10-year follow-up, risk factors for cardiovascular disease were recorded. Duration of RA and CRP levels were independently associated with NT-proBNP in the final model that was adjusted for gender, age, and creatinine levels (r2 adjusted = 0.38; P < 0.001). In the longitudinal analyses, which adjusted for age, gender, and time of follow-up, we found that repeated measures of CRP predicted NT-proBNP levels (P < 0.001). Conclusion CRP levels are linearly associated with levels of NT-proBNP in cross-sectional and longitudinal analyses of patients with RA. The independent associations of NT-proBNP levels and markers of disease activity with clinical cardiovascular endpoints need to be further investigated. PMID:18573197

Prospective randomized controlled study on small-window craniotomy versus ordinary large-window craniotomy in the evacuation of epidural hematoma

Directory of Open Access Journals (Sweden)

Lian-shui HU

2014-05-01

Full Text Available There is still controversy on the clinical efficacy of small-window craniotomy (SWCT for acute epidural hematoma with concurrent early-phase cerebral herniation. This study compared multiple surgical and prognostic parameters of SWCT versus ordinary large-window craniotomy (LWCT, which aimed at providing evidences for surgical decision. Compared with LWCT (N = 51, SWCT (N = 44 displayed shortened average operation time (P = 0.000, reduced intraoperative blood loss (P = 0.000 and lessened intraoperative blood transfusion (P = 0.031. Moreover, there was no differences of postoperative residual hematoma (P = 0.141, postoperative palinesthesia time (P = 0.201, the ratio of postoperative secondary ischemia (P = 0.865 or cerebral edema (P = 0.879, and 6-month Glasgow Outcome Scale (GOS score (P = 0.603 between the two surgical approaches.  Results suggested that, for patients with acute epidural hematoma and concurrent early-phase cerebral herniation, SWCT could effectively evacuate hematoma and relief brain herniation without significant differences of effect and prognosis from LWCT. In addition, SWCT has several advantages such as significantly reduced operation time, intraoperative blood loss and blood transfusion. doi: 10.3969/j.issn.1672-6731.2014.05.013

Biochemical properties of the matrix metalloproteinase NtMMP1 from Nicotiana tabacum cv. BY-2 suspension cells.

Science.gov (United States)

Mandal, Manoj K; Fischer, Rainer; Schillberg, Stefan; Schiermeyer, Andreas

2010-09-01

A zinc-dependent matrix metalloproteinase (NtMMP1) found in the plasma membrane of Nicotiana tabacum cv. Bright Yellow 2 (BY-2) suspension cells is thought to be responsible for the degradation of recombinant proteins secreted into the culture supernatant. We have characterized the proteolytic activity of NtMMP1 by expressing a recombinant derivative lacking the C-terminal transmembrane domain in yeast. After purifying the protein by affinity chromatography, its autocatalytic activity was analyzed using monoclonal antibodies raised against its N-terminal and C-terminal portions. Both the unprocessed and processed forms of NtMMP1 displayed caseinolytic activity and N-terminal sequencing identified an autocatalytic cleavage site within the sequence motif HFSFFP, which is similar to the corresponding sequences of the human matrix metalloproteinases stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10). Unlike all other matrix metalloproteinases investigated so far, NtMMP1 contains a disulfide bond within its propeptide thus rendering the proenzyme catalytically active. Kinetic analysis of NtMMP1 with a synthetic substrate revealed a K(m) of 10.55 +/- 0.9 microM, a k(cat) of 0.6 +/- 0.01 s(-1) and maximum activity at pH 7.5. We found that NtMMP1 degrades Desmodus rotundus salivary plasminogen activator alpha 1 (DSPAalpha1), a biopharmaceutical protein, that has proven difficult to produce in tobacco BY-2 cells. This provides a likely explanation for the frequent instability of secreted recombinant biopharmaceuticals produced in plant suspension cell cultures. Our data suggest new avenues that can be explored to improve the production of pharmaceutical proteins in plants and plant cells.

Development and performance test of a new high power RF window in S-band PLS-II LINAC

Science.gov (United States)

Hwang, Woon-Ha; Joo, Young-Do; Kim, Seung-Hwan; Choi, Jae-Young; Noh, Sung-Ju; Ryu, Ji-Wan; Cho, Young-Ki

2017-12-01

A prototype of RF window was developed in collaboration with the Pohang Accelerator Laboratory (PAL) and domestic companies. High power performance tests of the single RF window were conducted at PAL to verify the operational characteristics for its application in the Pohang Light Source-II (PLS-II) linear accelerator (Linac). The tests were performed in the in-situ facility consisting of a modulator, klystron, waveguide network, vacuum system, cooling system, and RF analyzing equipment. The test results with Stanford linear accelerator energy doubler (SLED) have shown no breakdown up to 75 MW peak power with 4.5 μs RF pulse width at a repetition rate of 10 Hz. The test results with the current operation level of PLS-II Linac confirm that the RF window well satisfies the criteria for PLS-II Linac operation.

Windows 8 simplified

CERN Document Server

McFedries, Paul

2012-01-01

The easiest way for visual learners to get started with Windows 8 The popular Simplified series makes visual learning easier than ever, and with more than 360,000 copies sold, previous Windows editions are among the bestselling Visual books. This guide goes straight to the point with easy-to-follow, two-page tutorials for each task. With full-color screen shots and step-by-step directions, it gets beginners up and running on the newest version of Windows right away. Learn to work with the new interface and improved Internet Explorer, manage files, share your computer, and much more. Perfect fo

Rails on Windows

CERN Document Server

Hibbs, Curt

2007-01-01

It's no secret that the entire Ruby onRails core team uses OS X as their preferreddevelopment environment. Becauseof this, it is very easy to findauthoritative information on the webabout using Rails on OS X. But the truthis that Windows developers using Railsprobably outnumber those using otherplatforms. A Windows development environmentcan be just as productive asany other platform. This is a guide to developing with Rubyon Rails under Windows. It won't teachyou how to write Ruby on Rails web applications,but it will show you what toolsto use and how to set them up to createa complete Rail

Need to Knowledge (NtK) Model: an evidence-based framework for generating technological innovations with socio-economic impacts.

Science.gov (United States)

Flagg, Jennifer L; Lane, Joseph P; Lockett, Michelle M

2013-02-15

Traditional government policies suggest that upstream investment in scientific research is necessary and sufficient to generate technological innovations. The expected downstream beneficial socio-economic impacts are presumed to occur through non-government market mechanisms. However, there is little quantitative evidence for such a direct and formulaic relationship between public investment at the input end and marketplace benefits at the impact end. Instead, the literature demonstrates that the technological innovation process involves a complex interaction between multiple sectors, methods, and stakeholders. The authors theorize that accomplishing the full process of technological innovation in a deliberate and systematic manner requires an operational-level model encompassing three underlying methods, each designed to generate knowledge outputs in different states: scientific research generates conceptual discoveries; engineering development generates prototype inventions; and industrial production generates commercial innovations. Given the critical roles of engineering and business, the entire innovation process should continuously consider the practical requirements and constraints of the commercial marketplace.The Need to Knowledge (NtK) Model encompasses the activities required to successfully generate innovations, along with associated strategies for effectively communicating knowledge outputs in all three states to the various stakeholders involved. It is intentionally grounded in evidence drawn from academic analysis to facilitate objective and quantitative scrutiny, and industry best practices to enable practical application. The Need to Knowledge (NtK) Model offers a practical, market-oriented approach that avoids the gaps, constraints and inefficiencies inherent in undirected activities and disconnected sectors. The NtK Model is a means to realizing increased returns on public investments in those science and technology programs expressly intended to

Ectopic Overexpression of a Novel R2R3-MYB, NtMYB2 from Chinese Narcissus Represses Anthocyanin Biosynthesis in Tobacco

Directory of Open Access Journals (Sweden)

Muhammad Anwar

2018-03-01

Full Text Available R2R3 MYB transcription factors play key functions in the regulation of secondary metabolites. In the present study, a R2R3 MYB transcriptional factor NtMYB2 was identified from Chinese narcissus (Narcissus tazetta L. var. Chinensis Roem and functionally characterized. NtMYB2 belongs to subgroup 4 of the R2R3 MYB transcription factor family that are related to repressor MYBs involved in the regulation of anthocyanin and flavonoids. Transient expression confirmed that NtMYB2 strongly reduced the red pigmentation induced by MYB- anthocyanin activators in agro-infiltrated tobacco leaves. Ectopic expression of NtMYB2 in tobacco significantly reduced the pigmentation and altered the floral phenotypes in transgenic tobacco flowers. Gene expression analysis suggested that NtMYB2 repressed the transcript levels of structural genes involved in anthocyanin biosynthesis pathway, especially the UFGT gene. NtMYB2 gene is expressed in all examined narcissus tissues; the levels of transcription in petals and corona is higher than other tissues and the transcription level at the bud stage was highest. These results show that NtMYB2 is involved in the regulation of anthocyanin biosynthesis pathway and may act as a repressor by down regulating the transcripts of key enzyme genes in Chinese narcissus.

Ectopic Overexpression of a Novel R2R3-MYB, NtMYB2 from Chinese Narcissus Represses Anthocyanin Biosynthesis in Tobacco.

Science.gov (United States)

Anwar, Muhammad; Wang, Guiqing; Wu, Jiacheng; Waheed, Saquib; Allan, Andrew C; Zeng, Lihui

2018-03-28

R2R3 MYB transcription factors play key functions in the regulation of secondary metabolites. In the present study, a R2R3 MYB transcriptional factor NtMYB2 was identified from Chinese narcissus ( Narcissus tazetta L. var. Chinensis Roem) and functionally characterized. NtMYB2 belongs to subgroup 4 of the R2R3 MYB transcription factor family that are related to repressor MYBs involved in the regulation of anthocyanin and flavonoids. Transient expression confirmed that NtMYB2 strongly reduced the red pigmentation induced by MYB- anthocyanin activators in agro-infiltrated tobacco leaves. Ectopic expression of NtMYB2 in tobacco significantly reduced the pigmentation and altered the floral phenotypes in transgenic tobacco flowers. Gene expression analysis suggested that NtMYB2 repressed the transcript levels of structural genes involved in anthocyanin biosynthesis pathway, especially the UFGT gene. NtMYB2 gene is expressed in all examined narcissus tissues; the levels of transcription in petals and corona is higher than other tissues and the transcription level at the bud stage was highest. These results show that NtMYB2 is involved in the regulation of anthocyanin biosynthesis pathway and may act as a repressor by down regulating the transcripts of key enzyme genes in Chinese narcissus.

Professional Windows Embedded Compact 7

CERN Document Server

Phung, Samuel; Joubert, Thierry; Hall, Mike

2011-01-01

Learn to program an array of customized devices and solutions As a compact, highly efficient, scalable operating system, Windows Embedded Compact 7 (WEC7) is one of the best options for developing a new generation of network-enabled, media-rich, and service-oriented devices. This in-depth resource takes you through the benefits and capabilities of WEC7 so that you can start using this performance development platform today. Divided into several major sections, the book begins with an introduction and then moves on to coverage of OS design, application development, advanced application developm

DEA Window Analysis for Measuring Port Efficiencies in Serbia

Directory of Open Access Journals (Sweden)

Danijela Pjevčević

2012-01-01

Full Text Available The aim of the paper is to apply Data Envelopment Analysis (DEA method in measuring and analyzing the efficiencies of ports on the river Danube. DEA window analysis is used to determine the efficiency of ports and to observe the possibility of changes in the port efficiency over time. A study is conducted to evaluate the efficiencies of ports on the territory of Serbia in order to identify the sources of inefficiencies and formulate proposals for improving the services of those ports and their operations through a four-year window analysis with port efficiency trends and average efficiencies. The progress is made in the measurement of port efficiency in relation to port productive activities - total area of warehouses, quay length, number of cranes and port throughput, for the Serbian river ports. Keywords: river ports, total area of warehouses, quay length, number of cranes, port throughput, port efficiency, DEA window analysis

Teach yourself visually Windows 10

CERN Document Server

McFedries, Paul

2015-01-01

Learn Windows 10 visually with step-by-step instructions Teach Yourself VISUALLY Windows 10 is the visual learner's guide to the latest Windows upgrade. Completely updated to cover all the latest features, this book walks you step-by-step through over 150 essential Windows tasks. Using full color screen shots and clear instruction, you'll learn your way around the interface, set up user accounts, play media files, download photos from your camera, go online, set up email, and much more. You'll even learn how to customize Windows 10 to suit the way you work best, troubleshoot and repair common

Development and trial operation of a site-wide computerized material accounting system at Kurchatov Institute

International Nuclear Information System (INIS)

Roumiantsev, A.N.; Ostroumov, Y.A.; Yevstropov, A.V.

1997-01-01

Since August 1994 Kurchatov Institute in cooperation with several US Department of Energy Laboratories has been developing a site-wide computerized material accounting system for nuclear materials. In 1994 a prototype system was put into trial operation at two Kurchatov facilities. Evaluation of this prototype led to the development of a new computerized material accounting system named KI-MACS, which has been operational since 1996. This system is a site-wide local secure computer network with centralized database capable of dealing with strictly confidential data and performing near-real time accountancy. It utilizes a Microsoft Windows NT operating system with SQL Server and Visual Basic, and has a 'star'-like network architecture. KI-MACS is capable of dealing with materials in itemized and bulk form, and can perform statistical evaluations of measurements and material balance. KI-MACS is fully integrated with bar code equipment, electronic scales, gamma-ray spectrometers and an Active Well Coincidence Counter, thus providing almost on-line evaluation and utilization of results of measurements, item identification and accounting. At present KI-MACS is being used in Physical Inventory Taking at the Kurchatov Central Storage Facility, and by the end of 1997 will be installed at twelve Kurchatov nuclear facilities

Development and trial operation of a site-wide computerized material accounting system at Kurchatov Institute

Energy Technology Data Exchange (ETDEWEB)

Roumiantsev, A.N.; Ostroumov, Y.A.; Yevstropov, A.V. [Kurchatov Institute RRC, Moscow (Russian Federation)] [and others

1997-11-01

Since August 1994 Kurchatov Institute in cooperation with several US Department of Energy Laboratories has been developing a site-wide computerized material accounting system for nuclear materials. In 1994 a prototype system was put into trial operation at two Kurchatov facilities. Evaluation of this prototype led to the development of a new computerized material accounting system named KI-MACS, which has been operational since 1996. This system is a site-wide local secure computer network with centralized database capable of dealing with strictly confidential data and performing near-real time accountancy. It utilizes a Microsoft Windows NT operating system with SQL Server and Visual Basic, and has a `star`-like network architecture. KI-MACS is capable of dealing with materials in itemized and bulk form, and can perform statistical evaluations of measurements and material balance. KI-MACS is fully integrated with bar code equipment, electronic scales, gamma-ray spectrometers and an Active Well Coincidence Counter, thus providing almost on-line evaluation and utilization of results of measurements, item identification and accounting. At present KI-MACS is being used in Physical Inventory Taking at the Kurchatov Central Storage Facility, and by the end of 1997 will be installed at twelve Kurchatov nuclear facilities.

ARGOS-NT: A computer based emergency management system

International Nuclear Information System (INIS)

Hoe, S.; Thykier-Nielsen, S.; Steffensen, L.B.

2000-01-01

In case of a nuclear accident or a threat of a release the Danish Emergency Management Agency is responsible for actions to minimize the consequences in Danish territory. To provide an overview of the situation, a computer based system called ARGOS-NT has been developed in 1993/94. This paper gives an overview of the system with emphasis on the prognostic part of the system. An example calculation shows the importance of correct landscape modeling. (author)

Resection of parathyroid tumor in the aorticopulmonary window without prior neck exploration

International Nuclear Information System (INIS)

McHenry, C.; Walsh, M.; Jarosz, H.; Henkin, R.; Tope, J.; Lawrence, A.M.; Paloyan, E.

1988-01-01

Of 522 patients with hyperparathyroidism operated on from 1973 to 1987 at our institution, there were seven (1.3%), each with an ectopic, hyperfunctioning mediastinal parathyroid adenoma, who required median sternotomy. In three of these seven patients, the tumor was located in the aorticopulmonary window. A 61-year-old woman with primary hyperparathyroidism had a preoperative thallium-technetium subtraction scan that showed thallium uptake at the base of the heart without any uptake in the neck. After further workup and without prior neck exploration, a parathyroid adenoma was found in the aorticopulmonary window through a median sternotomy. Six months later, serum calcium, phosphorus, and parathyroid hormone values remain normal. Two other cases of parathyroid adenoma in the aorticopulmonary window are presented. Of these two patients, the thallium scan was a key element in the immediate mediastinal exploration of one, who was transferred from another hospital comatose and intubated, in acute hypercalcemic crisis. Since mediastinal parathyroid tumors that necessitate median sternotomy occur in less than 2% of patients with primary hyperparathyroidism, we do not advocate routine preoperative localization studies before an initial cervical operation; localization, however, may be justified in selected cases, such as in critically ill patients or in instances of acute hyperparathyroidism, when the first operation needs to be curative

Windows registry forensics advanced digital forensic analysis of the Windows registry

CERN Document Server

Carvey, Harlan

2011-01-01

Harlan Carvey brings readers an advanced book on Windows Registry - the most difficult part of Windows to analyze in forensics! Windows Registry Forensics provides the background of the Registry to help develop an understanding of the binary structure of Registry hive files. Approaches to live response and analysis are included, and tools and techniques for postmortem analysis are discussed at length. Tools and techniques will be presented that take the analyst beyond the current use of viewers and into real analysis of data contained in the Registry. This book also has a DVD containing tools, instructions and videos.

Fabrication of Microcapsules for Dye-Doped Polymer-Dispersed Liquid Crystal-Based Smart Windows.

Science.gov (United States)

Kim, Mingyun; Park, Kyun Joo; Seok, Seunghwan; Ok, Jong Min; Jung, Hee-Tae; Choe, Jaehoon; Kim, Do Hyun

2015-08-19

A dye-doped polymer-dispersed liquid crystal (PDLC) is an attractive material for application in smart windows. Smart windows using a PDLC can be operated simply and have a high contrast ratio compared to those of other devices that employed photochromic or thermochromic material. However, in conventional dye-doped PDLC methods, dye contamination can cause problems and has a limited degree of commercialization of electric smart windows. Here, we report on an approach to resolve dye-related problems by encapsulating the dye in monodispersed capsules. By encapsulation, a fabricated dye-doped PDLC had a contrast ratio of >120 at 600 nm. This fabrication method of encapsulating the dye in a core-shell structured microcapsule in a dye-doped PDLC device provides a practical platform for dye-doped PDLC-based smart windows.

Handheld White Light Interferometer for Measuring Defect Depth in Windows

Science.gov (United States)

Youngquist, Robert; Simmons, Stephen; Cox, Robert

2010-01-01

Accurate quantification of defects (scratches and impacts) is vital to the certification of flight hardware and other critical components. The amount of damage to a particular component contributes to the performance, reliability, and safety of a system, which ultimately affects the success or failure of a mission or test. The launch-commit criteria on a Space Shuttle Orbiter window are governed by the depth of the defects that are identified by a visual inspection. This measurement of a defect is not easy to obtain given the environment, size of the defect, and location of the window(s). The determination of depth has typically been performed by taking a mold impression and measuring the impression with an optical profiling instrument. Another method of obtaining an estimate of the depth is by using a refocus microscope. To use a refocus microscope, the surface of the glass and bottom of the defect are, in turn, brought into focus by the operator. The amount of movement between the two points corresponds to the depth of the defect. The refocus microscope requires a skilled operator and has been proven to be unreliable when used on Orbiter windows. White light interferometry was chosen as a candidate to replace the refocus microscope. The White Light Interferometer (WLI) was developed to replace the refocus microscope as the instrument used for measuring the depth of defects in Orbiter windows. The WLI consists of a broadband illumination source, interferometer, detector, motion control, displacement sensor, mechanical housing, and support electronics. The illumination source for the WLI is typically a visible light emitting diode (LED) or a near-infrared superluminescent diode (SLD) with power levels of less than a milliwatt. The interferometer is a Michelson configuration consisting of a 1-in. (2.5-cm) cube beam splitter, a 0.5-in. (1.3-cm) optical window as a movable leg (used to closely match the return intensity of the fixed leg from the window), and a

Window observers for linear systems

Directory of Open Access Journals (Sweden)

Utkin Vadim

2000-01-01

Full Text Available Given a linear system x ˙ = A x + B u with output y = C x and a window function ω ( t , i.e., ∀ t , ω ( t ∈ {0,1 }, and assuming that the window function is Lebesgue measurable, we refer to the following observer, x ˆ = A x + B u + ω ( t L C ( x − x ˆ as a window observer. The stability issue is treated in this paper. It is proven that for linear time-invariant systems, the window observer can be stabilized by an appropriate design under a very mild condition on the window functions, albeit for linear time-varying system, some regularity of the window functions is required to achieve observer designs with the asymptotic stability. The corresponding design methods are developed. An example is included to illustrate the possible applications

Window Selection Tool | Efficient Windows Collaborative

Science.gov (United States)

Louisville LA Lake Charles LA New Orleans LA Shreveport MA Boston MD Baltimore ME Portland MI Detroit MI Window Selection Tool will take you through a series of design conditions pertaining to your design and

Windows Server 2003 Active Directory Design and Implementation Creating, Migrating, and Merging Networks

CERN Document Server

Savill, John

2005-01-01

This book is for Windows network administrators, analysts, or architects,  with a grasp of the basic operations of Active Directory, and are looking for a book that goes beyond rudimentary operations. However, all of the concepts are explained from the g

Transfection using hydroxyapatite nanoparticles in the inner ear via an intact round window membrane in chinchilla

Energy Technology Data Exchange (ETDEWEB)

Wu Xuewen; Ding Dalian [Central South University, Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital (China); Jiang Haiyan [State University of New York at Buffalo, Center for Hearing and Deafness (United States); XingXiaowei [Central South University, Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital (China); Huang, Suping [Central South University, State Key Laboratory of Powder Metallurgy (China); Liu Hong [Central South University, Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital (China); Chen Zhedong [Central South University, State Key Laboratory of Powder Metallurgy (China); Sun Hong, E-mail: shjhaj@vip.163.com [Central South University, Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital (China)

2012-01-15

Hydroxyapatite nanoparticles (nHAT) are known to have excellent biocompatibility, and have attracted increasing attention as new candidates of non-viral vectors for gene therapy. In our previous studies, nHAT carrying a therapeutic gene and a reporter gene were successfully transfected into the spiral ganglion neurons in the inner ear of guinea pigs in vivo as well as in the cultured cell lines, although the transfection efficiencies were never higher than 30%. In this study, the surface modification of nHAT with polyethylenimine (PEI) was made (PEI-nHAT, diameter = 73.09 {+-} 27.32 nm) and a recombinant plasmid carrying enhanced green fluorescent protein (EGFP) gene and neurotrophin-3 (NT-3) gene was constructed as pEGFPC2-NT3. The PEI modified nHAT and the recombinant plasmid was then connected to form the nHAT-based vector-gene complex (PEI-nHAT-pEGFPC2-NT3). This complex was then placed onto the intact round window membranes of the chinchillas for inner ear transfection. Auditory brainstem response (ABR) was tested to evaluate auditory function. Green fluorescence of EGFP was observed using confocal microscopy 48 h after administering vector-gene complexes. There was no significant threshold shift in tone burst-evoked ABR at any tested frequency. Abundant, condensed green fluorescence was found in dark cells on both sides of the crista and around the macula of the utricle. Scattered EGFP signals were also detected in vestibular hair cells, some Schwann cells in the cochlear spiral ganglion region, some outer pillar cells in the organ of Corti, and a few cells in the stria vascularis. The density of green fluorescence-marked cells was obviously higher in the vestibular dark cell area than in other areas of the inner ear, suggesting that vestibular dark cells may have the ability to actively engulf the nHAT-based vector-gene complexes. Considering the high transfection efficiency in the vestibular system, PEI-nHAT may be a potential vector for gene therapy of

Color Wheel Windows

Science.gov (United States)

Leonard, Stephanie

2012-01-01

In this article, the author describes a painting and drawing lesson which was inspired by the beautiful circular windows found in cathedrals and churches (also known as "rose windows"). This two-week lesson would reinforce both the concept of symmetry and students' understanding of the color wheel. (Contains 1 online resource.)

Phosphatidylinositol (4,5)bisphosphate inhibits K+-efflux channel activity in NT1 tobacco cultured cells.

Science.gov (United States)

Ma, Xiaohong; Shor, Oded; Diminshtein, Sofia; Yu, Ling; Im, Yang Ju; Perera, Imara; Lomax, Aaron; Boss, Wendy F; Moran, Nava

2009-02-01

In the animal world, the regulation of ion channels by phosphoinositides (PIs) has been investigated extensively, demonstrating a wide range of channels controlled by phosphatidylinositol (4,5)bisphosphate (PtdInsP2). To understand PI regulation of plant ion channels, we examined the in planta effect of PtdInsP2 on the K+-efflux channel of tobacco (Nicotiana tabacum), NtORK (outward-rectifying K channel). We applied a patch clamp in the whole-cell configuration (with fixed "cytosolic" Ca2+ concentration and pH) to protoplasts isolated from cultured tobacco cells with genetically manipulated plasma membrane levels of PtdInsP2 and cellular inositol (1,4,5)trisphosphate: "Low PIs" had depressed levels of these PIs, and "High PIs" had elevated levels relative to controls. In all of these cells, K channel activity, reflected in the net, steady-state outward K+ currents (IK), was inversely related to the plasma membrane PtdInsP2 level. Consistent with this, short-term manipulations decreasing PtdInsP2 levels in the High PIs, such as pretreatment with the phytohormone abscisic acid (25 microM) or neutralizing the bath solution from pH 5.6 to pH 7, increased IK (i.e. NtORK activity). Moreover, increasing PtdInsP2 levels in controls or in abscisic acid-treated high-PI cells, using the specific PI-phospholipase C inhibitor U73122 (2.5-4 microM), decreased NtORK activity. In all cases, IK decreases stemmed largely from decreased maximum attainable NtORK channel conductance and partly from shifted voltage dependence of channel gating to more positive potentials, making it more difficult to activate the channels. These results are consistent with NtORK inhibition by the negatively charged PtdInsP2 in the internal plasma membrane leaflet. Such effects are likely to underlie PI signaling in intact plant cells.

Dicer-like 3 produces transposable element-associated 24-nt siRNAs that control agricultural traits in rice

Science.gov (United States)

Wei, Liya; Gu, Lianfeng; Song, Xianwei; Cui, Xiekui; Lu, Zhike; Zhou, Ming; Wang, Lulu; Hu, Fengyi; Zhai, Jixian; Meyers, Blake C.; Cao, Xiaofeng

2014-01-01

Transposable elements (TEs) and repetitive sequences make up over 35% of the rice (Oryza sativa) genome. The host regulates the activity of different TEs by different epigenetic mechanisms, including DNA methylation, histone H3K9 methylation, and histone H3K4 demethylation. TEs can also affect the expression of host genes. For example, miniature inverted repeat TEs (MITEs), dispersed high copy-number DNA TEs, can influence the expression of nearby genes. In plants, 24-nt small interfering RNAs (siRNAs) are mainly derived from repeats and TEs. However, the extent to which TEs, particularly MITEs associated with 24-nt siRNAs, affect gene expression remains elusive. Here, we show that the rice Dicer-like 3 homolog OsDCL3a is primarily responsible for 24-nt siRNA processing. Impairing OsDCL3a expression by RNA interference caused phenotypes affecting important agricultural traits; these phenotypes include dwarfism, larger flag leaf angle, and fewer secondary branches. We used small RNA deep sequencing to identify 535,054 24-nt siRNA clusters. Of these clusters, ∼82% were OsDCL3a-dependent and showed significant enrichment of MITEs. Reduction of OsDCL3a function reduced the 24-nt siRNAs predominantly from MITEs and elevated expression of nearby genes. OsDCL3a directly targets genes involved in gibberellin and brassinosteroid homeostasis; OsDCL3a deficiency may affect these genes, thus causing the phenotypes of dwarfism and enlarged flag leaf angle. Our work identifies OsDCL3a-dependent 24-nt siRNAs derived from MITEs as broadly functioning regulators for fine-tuning gene expression, which may reflect a conserved epigenetic mechanism in higher plants with genomes rich in dispersed repeats or TEs. PMID:24554078

Clinical Significance of Determination of the Serum Levels of NT-proBNP and hs-CRP in Patients with Acute Coronary Syndrome

International Nuclear Information System (INIS)

Zheng Zhaojun; Zheng Jing; Sun Weili; Yuan Yuan; Tao Jian; Li Weipeng

2010-01-01

To explore the clinical significance the serum levels of N-Terminal proB-Type natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) in patients with acute coronary syndrome,the serum levels of NT-proBNP and hs-CRP in patients and normal controls were determined by ECi Immunity Analyzer and radioimmunoassay respectively. The results showed that the serum levels of NT-proBNP and hs-CRP in patients with acute coronary syndrome were significantly higher than that of controls (P<0.05). The diagnostic specificity for acute coronary syndrome was 100% by combined detection of NT-proBNP and hs-CRP. The results suggest that the combined detection of serum NT-proBNP and hs-CRP levels are very important to evaluate heart function in patients with acute coronary syndrome. (authors)

The NT-ProBNP Test in Subjects with End-Stage Renal Disease on Hemodialysis Presenting with Acute Dyspnea: Is Knowing Worth the Cost?

Directory of Open Access Journals (Sweden)

Shaffer R. S. Mok

2013-01-01

Full Text Available Background. The NT-ProBNP/BNP test has been validated as a marker for determining the etiology of acute dyspnea. In the setting of end-stage renal disease on hemodialysis (ESRD on HD, the utility of the NT-ProBNP/BNP test has not been validated. This study examines the clinical utility of the NT-ProBNP test in the setting of ESRD on HD patients presenting with acute dyspnea. Methods. A retrospective case series of 250 subjects were admitted to Cooper University Hospital, 07/2010-03/2011, with ESRD and HD presenting with dyspnea. The incidences of echocardiography, cardiology consultation, and NT-ProBNP elevated and normal were examined. Correlation coefficients were calculated for NT-ProBNP with age (years, estimated dry weight (kg, amount of fluid removed (L, and ejection fraction (EF in % among other echocardiography parameters. Results. Of the total sample 235 patients had NT-ProBNP levels performed. Cardiology consults were placed in 68.8% and 58% who underwent echocardiography. Of those for whom an echocardiography was performed estimated mean EFs of 54.6%, 50.8%, and 61.7% were observed among the NT-ProBNP elevated group, normal group, and no NT-ProBNP group, respectively. No differences were detected in all other echocardiography measurements. No correlation was observed between NT-ProBNP and age (, baseline EDW (, amount of fluid removed (, or EF (. Conclusion. In the setting of ESRD on HD, the NT-ProBNP test has no clinical utility in determining the etiology of acute dyspnea. This can be demonstrated through echocardiographic and therapeutic parameters measured in this study.

Mortality and preoperative cardiac function in vascular amputees: an N-terminal pro-brain natriuretic peptide (NT-proBNP) pilot study

OpenAIRE

Riemersma, Marcel; Dijkstra, Pieter U.; van Veldhuisen, Dirk Jan; Muskiet, Frits A. J.; van den Dungen, Jan A. M. M.; Geertzen, Jan H. B.

2008-01-01

Objective: To determine preoperative ventricular function in vascular amputees by measuring N-terminal pro-brain natriuretic peptide (NT-proBNP) and to analyse the relationship between NT-proBNP levels and 30-day postoperative mortality. Design: Prospective pilot study. Subjects and methods: In 19 patients planned for a lower limb amputation for nonreconstructable peripheral arterial disease NT-proBNP was measured the day before amputation. Results: Four amputees died within 30 days after the...

The space station window observational research facility; a high altitude imaging laboratory

International Nuclear Information System (INIS)

Runco, Susan K.; Eppler, Dean B.; Scott, Karen P.

1999-01-01

Earth Science will be one of the major research areas to be conducted on the International Space Station. The facilities from which this research will be accomplished are currently being constructed and will be described in this paper. By April 1999, the International Space Station nadir viewing research window fabrication will be completed and ready for installation. The window will provide a 20 inch (51 cm) diameter clear aperture. The three fused silica panes, which make up the window are fabricated such that the total peak-to-valley wavefront error in transmission through the three panes over any six inch diameter aperture does not exceed λ/7 where the reference wavelength is 632.8 nm. The window will have over 90% transmission between about 400 and 750, above 50% transmission between about 310 nm and 1375 nm and 40% transmission between 1386 nm and 2000 nm. The Window Operational Research Facility (WORF) is designed to accommodate payloads using this research window. The WORF will provide access to the International Space Station utilities such as data links, temperature cooling loops and power. Emphasis has been placed on the factors which will make this facility an optimum platform for conducting Earth science research

The Impact Of The MCU Life Extension Solvent On Sludge Batch 8 Projected Operating Windows

International Nuclear Information System (INIS)

Peeler, D. K.; Edwards, T. B.; Stone, M. E.

2013-01-01

As a part of the Actinide Removal Process (ARP)/Modular Caustic Side Solvent Extraction Unit (MCU) Life Extension Project, a next generation solvent (NGS) and a new strip acid will be deployed. The strip acid will be changed from dilute nitric acid to dilute boric acid (0.01 M). Because of these changes, experimental testing or evaluations with the next generation solvent are required to determine the impact of these changes (if any) to Chemical Process Cell (CPC) activities, glass formulation strategies, and melter operations at the Defense Waste Processing Facility (DWPF). The introduction of the dilute (0.01M) boric acid stream into the DWPF flowsheet has a potential impact on glass formulation and frit development efforts since B2O3 is a major oxide in frits developed for DWPF. Prior knowledge of this stream can be accounted for during frit development efforts but that was not the case for Sludge Batch 8 (SB8). Frit 803 has already been recommended and procured for SB8 processing; altering the frit to account for the incoming boron from the strip effluent (SE) is not an option for SB8. Therefore, the operational robustness of Frit 803 to the introduction of SE including its compositional tolerances (i.e., up to 0.0125M boric acid) is of interest and was the focus of this study. The primary question to be addressed in the current study was: What is the impact (if any) on the projected operating windows for the Frit 803 - SB8 flowsheet to additions of B2O3 from the SE in the Sludge Receipt and Adjustment Tank (SRAT)? More specifically, will Frit 803 be robust to the potential compositional changes occurring in the SRAT due to sludge variation, varying additions of ARP and/or the introduction of SE by providing access to waste loadings (WLs) of interest to DWPF? The Measurement Acceptability Region (MAR) results indicate there is very little, if any, impact on the projected operating windows for the Frit 803 - SB8 system regardless of the presence or absence of

National Fenestration Rating Council (NFRC) | Efficient Windows

Science.gov (United States)

Collaborative Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring

Troponin T and NT ProBNP Levels in Gestational, Type 1 and Type 2 Diabetic Mothers and Macrosomic Infants.

Science.gov (United States)

Mert, Mustafa Kurthan; Satar, Mehmet; Özbarlas, Nazan; Yaman, Akgün; Özgünen, Fatma Tuncay; Asker, Hüseyin Selim; Çekinmez, Eren Kale; Tetiker, Tamer

2016-01-01

This study compares NT proBNP and troponin T levels in umbilical cord arterial blood and postnatal echocardiographic findings for infants of gestational and pregestational diabetic mothers and macrosomic infants. Twenty-seven infants of pregestational diabetic mothers, 61 infants of gestational diabetic mothers and 37 macrosomic infants of nondiabetic mothers were prospectively enrolled in this study along with a control group of 58 healthy infants of mothers without any pregestational or gestational disorders as the control group. All enrollees were born after 34 weeks of gestation. For this study, umbilical cord blood was drawn during delivery to determine NT proBNP and troponin T levels. Echocardiography was performed 24-72 h after the delivery. Umbilical cord troponin T and NT proBNP levels were found to be higher in the diabetic and macrosomic groups than in the control group (all of them p gestational infants of diabetic mothers groups (r = 0.564 and r = 0.560, respectively, p gestational diabetic mothers were divided into two groups according to HbA1c levels in the third trimester as good (6.1 %) metabolic control. In the good and suboptimal metabolic control diabetic groups, NT proBNP levels were also positively correlated with interventricular septum thickness (r = 0.536 and r = 0.576, respectively, p mothers and the control group, the myocardial performance index of macrosomic infants was lower than that of the control group (p = 0.017). Cardiac biomarkers (NT proBNP and troponin T) were elevated in infants of diabetic mothers and macrosomic infants. While there was a positive correlation between NT proBNP levels and cardiac structure in infants of pregestational and gestational diabetic mothers, there was no relationship between NT proBNP levels and cardiac function.

Highly Insulating Windows with a U-value less than 0.6 W/m2K

Energy Technology Data Exchange (ETDEWEB)

Wendell Rhine; Ying Tang; Wenting Dong; Roxana Trifu; Reduane Begag

2008-11-30

satisfying constraints such as durability, cost, user acceptance, size limits, and environmental safety concerns. The energy efficient daylighting window will consist of a translucent and resilient aerogel panel sandwiched between glass panes in double glazed windows. Compared to the best windows available today, the double glazed translucent windows with 1/2-inch aerogel inserts will have a U-value of 1.2 W/m{sup 2} K (0.211 BTU/ft{sup 2} h F) without any coating or low conductivity fill gases. These windows will be more effective than the windows with an Energy Star rating of U-2 W/m{sup 2} K and could be made even more efficient by using low-e coated glass glazings and inert gas fills. This report summarizes the work accomplished on Cooperative Agreement DE-FC26-03NT41950. During this project, Aspen Aerogels made transparent and translucent aerogels from TMOS and TEOS. We characterized the transparency of the aerogels, reinforced the transparent aerogels with fibers and prepared large translucent aerogel panels and blankets. We also conducted an initial market study for energy efficient translucent windows. A lab-scale process was developed that could be scaled-up to manufacture blankets of these translucent aerogels. The large blankets prepared were used to fabricate prototype translucent windows and skylights. The primary goal of this project was to develop transparent, resilient, hydrophobic silica aerogels that have low thermal conductivities (R-10/inch) to be used to produce aerogel insulated double-glazing windows with a U value of 0.6 W/m{sup 2}K. To meet this objective we developed a process and equipment to produce blankets of translucent, hydrophobic aerogel. We focused on silica, organically-modified silica aerogels (Ormosils), and fiber reinforced silica aerogels due to the appreciable expertise in silica sol-gel processing available with the personnel at Aspen Aerogels, and also due to the quantity of knowledge available in the scientific literature. The

U-Factor (U-value) | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Genetic transformation of tobacco NT1 cells with Agrobacterium tumefaciens.

Science.gov (United States)

Mayo, Kristin J; Gonzales, Barbara J; Mason, Hugh S

2006-01-01

This protocol is used to produce stably transformed tobacco (Nicotiana tabacum) NT1 cell lines, using Agrobacterium tumefaciens-mediated DNA delivery of a binary vector containing a gene encoding hepatitis B surface antigen and a gene encoding the kanamycin selection marker. The NT1 cultures, at the appropriate stage of growth, are inoculated with A. tumefaciens containing the binary vector. A 3-day cocultivation period follows, after which the cultures are rinsed and placed on solid selective medium. Transformed colonies ('calli') appear in approximately 4 weeks; they are subcultured until adequate material is obtained for analysis of antigen production. 'Elite' lines are selected based on antigen expression and growth characteristics. The time required for the procedure from preparation of the plant cell materials to callus development is approximately 5 weeks. Growth of selected calli to sufficient quantities for antigen screening may require 4-6 weeks beyond the initial selection. Creation of the plasmid constructs, transformation of the A. tumefaciens line, and ELISA and Bradford assays to assess protein production require additional time.

Highly Flexible, Multipixelated Thermosensitive Smart Windows Made of Tough Hydrogels.

Science.gov (United States)

La, Thanh-Giang; Li, Xinda; Kumar, Amit; Fu, Yiyang; Yang, Shu; Chung, Hyun-Joong

2017-09-27

In a cold night, a clear window that will become opaque while retaining the indoor heat is highly desirable for both privacy and energy efficiency. A thermally responsive material that controls both the transmittance of solar radiance (predominantly in the visible and near-infrared wavelengths) and blackbody radiation (mainly in the mid-infrared) can realize such windows with minimal energy consumption. Here, we report a smart coating made from polyampholyte hydrogel (PAH) that transforms from a transparency state to opacity to visible radiation and strengthens opacity to mid-infrared when lowering the temperature as a result of phase separation between the water-rich and polymer-rich phases. To match a typical temperature fluctuation during the day, we fine-tune the phase transition temperature between 25 and 55 °C by introducing a small amount of relatively hydrophobic monomers (0.1 to 0.5 wt % to PAH). To further demonstrate an actively controlled, highly flexible, and high-contrast smart window, we build in an array of electric heaters made of printed elastomeric composite. The multipixelated window offers rapid switching, ∼70 s per cycle, whereas the device can withstand high strain (up to 80%) during operations.

Right-to-left-shunt detected by c-TCD using the orbital window in comparison with temporal bone windows.

Science.gov (United States)

Kobayashi, Kazuto; Kimura, Kazumi; Iguchi, Yasuyuki; Sakai, Kenichirou; Aoki, Junya; Iwanaga, Takeshi; Shibazaki, Kensaku

2012-01-01

There have been some reports on right-to-left shunt as a cause of cryptogenic stroke. Although contrast transcranial Doppler (c-TCD) can detect RLS, an insufficient temporal window has occasionally restricted its applicability. Thus, we compared the rates of detecting RLS among temporal windows for the middle cerebral arteries (MCAs) and the orbital window for the internal carotid artery (ICA) on c-TCD. We used c-TCD to detect RLS in patients with suspected ischemic stroke. We enrolled patients who had both sufficient bilateral temporal windows for MCAs and a right orbital window for ICA and performed c-TCD using all three windows simultaneously. We enrolled 106 consecutive patients and identified microembolic signals (MES) in 30 (28%) of them. Among these 30 patients, 15 had MES from all 3 windows. When these 30 patients were defined as being positive for RLS, the rates of detection were 67%, 73%, and 80% from the right temporal, left temporal, and right orbital windows, respectively (P= .795). The right orbital window as well as the temporal window for c-TCD could detect RLS. Insonation from the orbital window should be useful for patients who lack temporal windows. Copyright © 2010 by the American Society of Neuroimaging.

Intrusion Prevention System Based on the Aççess Control Mechanism in the Operating System Miçrosoft Windows

Directory of Open Access Journals (Sweden)

V. S. Matveeva

2012-03-01

Full Text Available It is suggested to implement an intrusion prevention system based on the access control mechanism of Microsoft Windows operating system to restrict the execution of malicious code. Most of the existing computer security facilities use behavioral and heuristic analyses based on an undocumented method of system calls interception that is not an uniform approach in designing of proactive security mechanism. The IPS is portable among different versions of the OS because it is implemented with documented functions only, it does not need to be updated and uses less system resources in comparison with another protection systems. The system protects from zero-day malware and therefore prevents companies from online-banking fraud that is a very actual problem of information security nowadays.

Image annotation under X Windows

Science.gov (United States)

Pothier, Steven

1991-08-01

A mechanism for attaching graphic and overlay annotation to multiple bits/pixel imagery while providing levels of performance approaching that of native mode graphics systems is presented. This mechanism isolates programming complexity from the application programmer through software encapsulation under the X Window System. It ensures display accuracy throughout operations on the imagery and annotation including zooms, pans, and modifications of the annotation. Trade-offs that affect speed of display, consumption of memory, and system functionality are explored. The use of resource files to tune the display system is discussed. The mechanism makes use of an abstraction consisting of four parts; a graphics overlay, a dithered overlay, an image overly, and a physical display window. Data structures are maintained that retain the distinction between the four parts so that they can be modified independently, providing system flexibility. A unique technique for associating user color preferences with annotation is introduced. An interface that allows interactive modification of the mapping between image value and color is discussed. A procedure that provides for the colorization of imagery on 8-bit display systems using pixel dithering is explained. Finally, the application of annotation mechanisms to various applications is discussed.

Hybrid window layer for photovoltaic cells

Science.gov (United States)

Deng, Xunming

2010-02-23

A novel photovoltaic solar cell and method of making the same are disclosed. The solar cell includes: at least one absorber layer which could either be a lightly doped layer or an undoped layer, and at least a doped window-layers which comprise at least two sub-window-layers. The first sub-window-layer, which is next to the absorber-layer, is deposited to form desirable junction with the absorber-layer. The second sub-window-layer, which is next to the first sub-window-layer, but not in direct contact with the absorber-layer, is deposited in order to have transmission higher than the first-sub-window-layer.

Lockout/Tagout - Turvalukituskäytäntö

OpenAIRE

Juhala, Ville

2017-01-01

Tämän opinnäytetyön tarkoituksena oli laatia kattava ohjeistus kuparitehtaan turvalukituksista. Työ tehtiin Aurubis Finland Oy:n kuparivalssaamoon. Ohjeistuksista tuli käydä ilmi turvalukitusten vaikutus lukittaviin laitteisiin sekä mahdolliset työturvallisuusriskit joita koneiden kanssa toimiessa tulee huomioida. Työn tavoitteena oli lisätä kunnossapidon työturvallisuutta ja selkeyttää koneiden kanssa työskentelyyn liittyviä käytäntöjä. Ohjeistukset laadittiin vahinkokäynnistymisen estoa...

Windows PowerShell 20 Bible

CERN Document Server

Lee, Thomas; Schill, Mark E; Tanasovski, Tome

2011-01-01

Here's the complete guide to Windows PowerShell 2.0 for administrators and developers Windows PowerShell is Microsoft's next-generation scripting and automation language. This comprehensive volume provides the background that IT administrators and developers need in order to start using PowerShell automation in exciting new ways. It explains what PowerShell is, how to use the language, and specific ways to apply PowerShell in various technologies. Windows PowerShell is Microsoft's standard automation tool and something that every Windows administrator will eventually have to understand; this b

Quantifying the evidence for dark matter in CoGeNT data

International Nuclear Information System (INIS)

Davis, Jonathan H.; McCabe, Christopher; Boehm, Céline

2014-01-01

We perform an independent analysis of data from the CoGeNT direct detection experiment to quantify the evidence for dark matter recoils. We critically re-examine the assumptions that enter the analysis, focusing specifically on the separation of bulk and surface events, the latter of which constitute a large background. This separation is performed using the event rise-time, with the surface events being slower on average. We fit the rise-time distributions for the bulk and surface events with a log-normal and Pareto distribution (which gives a better fit to the tail in the bulk population at high rise-times) and account for the energy-dependence of the bulk fraction using a cubic spline. Using Bayesian and frequentist techniques and additionally investigating the effect of varying the rise-time cut, the bulk background spectrum and bin-sizes, we conclude that the CoGeNT data show a preference for light dark matter recoils at less than 1σ

Schematic Window Methodology Project

Data.gov (United States)

National Aeronautics and Space Administration — The aim of this IRAD is to produce a generic launch window analyzer (SWM) that allows for large-scale rapid analysis of a launch window and orbit design trade space....

Windows 7 resource kit

CERN Document Server

Northrup, Tony; Honeycutt, Jerry; Wilson, Ed

2009-01-01

In-depth and comprehensive, this RESOURCE KIT delivers the information you need to administer your Windows 7 system. You get authoritative technical guidance from those who know the technology best-Microsoft Most Valuable Professionals (MVPs) and the Windows 7 product team-along with essential scripts and resources. In addition, "Direct from the Source" sidebars offer deep insights and troubleshooting tips from the Windows 7 team. Get expert guidance on how to: Use Microsoft Deployment Toolkit best practices and tools. Plan user-state migration and test application compatibility.

The Efficient Windows Collaborative

Energy Technology Data Exchange (ETDEWEB)

Petermann, Nils

2006-03-31

The Efficient Windows Collaborative (EWC) is a coalition of manufacturers, component suppliers, government agencies, research institutions, and others who partner to expand the market for energy efficient window products. Funded through a cooperative agreement with the U.S. Department of Energy, the EWC provides education, communication and outreach in order to transform the residential window market to 70% energy efficient products by 2005. Implementation of the EWC is managed by the Alliance to Save Energy, with support from the University of Minnesota and Lawrence Berkeley National Laboratory.

The NtAMI1 gene functions in cell division of tobacco BY-2 cells in the presence of indole-3-acetamide.

Science.gov (United States)

Nemoto, Keiichirou; Hara, Masamitsu; Suzuki, Masashi; Seki, Hikaru; Muranaka, Toshiya; Mano, Yoshihiro

2009-01-22

Tobacco (Nicotiana tabacum) Bright Yellow-2 (BY-2) cells can be grown in medium containing indole-3-acetamide (IAM). Based on this finding, the NtAMI1 gene, whose product is functionally equivalent to the AtAMI1 gene of Arabidopsis thaliana and the aux2 gene of Agrobacterium rhizogenes, was isolated from BY-2 cells. Overexpression of the NtAMI1 gene allowed BY-2 cells to proliferate at lower concentrations of IAM, whereas suppression of the NtAMI1 gene by RNA interference (RNAi) caused severe growth inhibition in the medium containing IAM. These results suggest that IAM is incorporated into plant cells and converted to the auxin, indole-3-acetic acid, by NtAMI1.

Composition of 12-18th century window glass in Belgium: Non-figurative windows in secular buildings and stained-glass windows in religious buildings

International Nuclear Information System (INIS)

Schalm, Olivier; Janssens, Koen; Wouters, Hilde; Caluwe, Danielle

2007-01-01

A set of ca. 500 window glass fragments originating from different historical sites in Belgium and covering the period 12 th -18 th century was analyzed by means of electron probe microanalysis. Most samples are archaeological finds deriving from non-figurative windows in secular buildings. However, the analyzed set also contains glass sampled from still existing non-figurative windows in secular buildings and stained-glass windows in religious buildings. A sudden compositional change at the end of the 14 th century can be noticed among the series of glass compositions that were obtained. These changes could be related to the use of different glassmaker recipes and to the introduction of new raw materials for glass making

Composition of 12-18 th century window glass in Belgium: Non-figurative windows in secular buildings and stained-glass windows in religious buildings

Science.gov (United States)

Schalm, Olivier; Janssens, Koen; Wouters, Hilde; Caluwé, Danielle

2007-07-01

A set of ca. 500 window glass fragments originating from different historical sites in Belgium and covering the period 12 th-18 th century was analyzed by means of electron probe microanalysis. Most samples are archaeological finds deriving from non-figurative windows in secular buildings. However, the analyzed set also contains glass sampled from still existing non-figurative windows in secular buildings and stained-glass windows in religious buildings. A sudden compositional change at the end of the 14 th century can be noticed among the series of glass compositions that were obtained. These changes could be related to the use of different glassmaker recipes and to the introduction of new raw materials for glass making.

High performance sapphire windows

Science.gov (United States)

Bates, Stephen C.; Liou, Larry

1993-02-01

High-quality, wide-aperture optical access is usually required for the advanced laser diagnostics that can now make a wide variety of non-intrusive measurements of combustion processes. Specially processed and mounted sapphire windows are proposed to provide this optical access to extreme environment. Through surface treatments and proper thermal stress design, single crystal sapphire can be a mechanically equivalent replacement for high strength steel. A prototype sapphire window and mounting system have been developed in a successful NASA SBIR Phase 1 project. A large and reliable increase in sapphire design strength (as much as 10x) has been achieved, and the initial specifications necessary for these gains have been defined. Failure testing of small windows has conclusively demonstrated the increased sapphire strength, indicating that a nearly flawless surface polish is the primary cause of strengthening, while an unusual mounting arrangement also significantly contributes to a larger effective strength. Phase 2 work will complete specification and demonstration of these windows, and will fabricate a set for use at NASA. The enhanced capabilities of these high performance sapphire windows will lead to many diagnostic capabilities not previously possible, as well as new applications for sapphire.

An Introduction to Parallel Cluster Computing Using PVM for Computer Modeling and Simulation of Engineering Problems

International Nuclear Information System (INIS)

Spencer, VN

2001-01-01

An investigation has been conducted regarding the ability of clustered personal computers to improve the performance of executing software simulations for solving engineering problems. The power and utility of personal computers continues to grow exponentially through advances in computing capabilities such as newer microprocessors, advances in microchip technologies, electronic packaging, and cost effective gigabyte-size hard drive capacity. Many engineering problems require significant computing power. Therefore, the computation has to be done by high-performance computer systems that cost millions of dollars and need gigabytes of memory to complete the task. Alternately, it is feasible to provide adequate computing in the form of clustered personal computers. This method cuts the cost and size by linking (clustering) personal computers together across a network. Clusters also have the advantage that they can be used as stand-alone computers when they are not operating as a parallel computer. Parallel computing software to exploit clusters is available for computer operating systems like Unix, Windows NT, or Linux. This project concentrates on the use of Windows NT, and the Parallel Virtual Machine (PVM) system to solve an engineering dynamics problem in Fortran

Development and production of radiation shielding window (RSW) glass: Indian scenario

International Nuclear Information System (INIS)

Phani, K.K.

2006-01-01

Nuclear energy/power and its peaceful applications play an ever increasing role in India. Irradiated nuclear fuels, irradiated structural materials from reactors, nuclear wastes and radio-isotopes emit high energy gamma radiations which are extremely health hazardous. These materials are handled remotely by manipulators inside the hot cells, which are constructed by shielding materials such as lead and concrete walls. The direct visual control of processes in the hot cells during operation demands the windows in the radiation shielding walls. These windows must provide the clear viewing but yet ensure the good protection to the working personnel from the high energy radiation

Ruling out cardiac failure: Cost-benefit analysis of a sequential testing strategy with NT-proBNP before echocardiography

Science.gov (United States)

Ferrandis, Maria-José; Ryden, Ingvar; Lindahl, Tomas L.

2013-01-01

Objectives To estimate the possible economic benefit of a sequential testing strategy with NT-proBNP to reduce the number of echocardiographies. Methods Retrospective study in a third-party payer perspective. The costs were calculated from three Swedish counties: Blekinge, Östergötland, and Uppland. Two cut-off levels of NT-proBNP were used: 400 and 300 pg/mL. The cost-effectiveness of the testing strategy was estimated through the short-term cost avoidance and reduction in demand for echocardiographies. Results The estimated costs for NT-proBNP tests and echocardiographies per county were reduced by 33%–36% with the 400 pg/mL cut-off and by 28%–29% with the 300 pg/mL cut-off. This corresponded to a yearly cost reduction of approximately €2–5 million per million inhabitants in these counties. Conclusion The use of NT-proBNP as a screening test could substantially reduce the number of echocardiographies in the diagnostic work-up of patients with suspected cardiac failure, as well as the associated costs. PMID:23230860

Windows 7 The Missing Manual

CERN Document Server

Pogue, David

2010-01-01

In early reviews, geeks raved about Windows 7. But if you're an ordinary mortal, learning what this new system is all about will be challenging. Fear not: David Pogue's Windows 7: The Missing Manual comes to the rescue. Like its predecessors, this book illuminates its subject with reader-friendly insight, plenty of wit, and hardnosed objectivity for beginners as well as veteran PC users. Windows 7 fixes many of Vista's most painful shortcomings. It's speedier, has fewer intrusive and nagging screens, and is more compatible with peripherals. Plus, Windows 7 introduces a slew of new features,

Improved Windows for Cold Climates

DEFF Research Database (Denmark)

Laustsen, Jacob Birck; Svendsen, Svend

2005-01-01

considerably by reducing the frame width, which results in a larger transparent area causing a larger solar gain but still main-taining a low thermal transmittance. Using three layers of glass with large gaps, using very slim frame profiles, and omitting the edge constructions that normally causes thermal...... windows with improved energy performance. Traditionally evaluation of the energy performance of windows has focused on the thermal transmittance, but as windows differ from the rest of the building envelope by allowing solar energy to enter the building, the total solar energy transmittance is equally...... important. In the heating season in cold climates the solar gain through windows can be utilized for space heating which results in a corresponding reduction in the energy production that is often based on fossil fuels. A suitable quantity for evaluating the energy performance of windows in a simple...

The value of T/NT in FDG imaging with a coincidence camera for diagnosis of pulmonary nodules and mass lesions

International Nuclear Information System (INIS)

Sun Da; Zhan Hongwei; Xu Wei; Ye Xiaojuan; Liu Qichang

2004-01-01

Objectives: To assess the value of T/NT in FDG imaging with a coincidence camera for diagnosis of pulmonary nodules and mass lesions. Methods: 18F-FDG imaging were performed in 57 patients with a mean age of 62.18 (range from 33 83 years old) for diagnosis of pulmonary nodules and mass lesions using a gamma camera with 1 inch crystal in coincidence mode (Siemens E.comduet). 175 296 MBq (5 8 mci) of 18F-FDG was given by iv on an empty stomach at least for 6 hours, and a whole body imaging without brain and legs was performed after 40 60 minutes. The count rate of target ROI and no-target ROI (T/NT) were calculated as a semiquantative analysis to differentiate malignant from inflammatory lesions. The result was compared with CT, MRI, and/or pathology. Results: The mean value of T/NT in malignant lesions (N=45) in lungs is 4.32 (range 1.61 10.62). But it is 1.52 (range 1.37 1.95) in inflammatory lesions (N=17) in lungs, and 4.09 (range 2.2 7.01) in lung tuberculosis lesions (N=5). In 45 malignant, the value of T/NT is less than 2.0 in only 3 lesions. So the overlapping of T/NT value is very little between malignant and inflammatory lesions. But there is full overlapping of T/NT value between malignant and tuberculosis lesions. Conclusions: Focal pulmonary nodules and mass lesions are commonly encountered in clinical practice, and PET with 18F-FDG has proved to be an accurate noninvasive test for identifying pulmonary malignant lesions. The technique of semiquantity with T/NT is useful to differentiate malignant from inflammatory lesions. But it is invalidate for distinguishing malignant from tuberculosis lesions. (authors)

NT-proBNP and Circulating Inflammation Markers in Prediction of a Normal Myocardial Scintigraphy in Patients with Symptoms of Coronary Artery Disease

DEFF Research Database (Denmark)

Rathcke, C.N.; Kjøller, Erik; Fogh-Andersen, N.

2010-01-01

with an intermediate risk of CAD or with known CAD with renewed suspicion of ischemia were referred to MPI. Blood samples were analyzed for N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP), YKL-40, IL-6, matrix metalloproteinase 9 (MMP-9) and high sensitive C-reactive protein (hs......CRP). Patients with myocardial perfusion defects had elevated levels of NT-proBNP (p95% regardless of existing CAD. Conclusions: 20-25% of patients suspected of CAD could have been spared a MPI by using a NT-proBNP cut-off concentration at 25 ng/l with a negative predictive value >95%. NT-proBNP has...

650-nm-band high-power and highly reliable laser diodes with a window-mirror structure

Science.gov (United States)

Shima, Akihiro; Hironaka, Misao; Ono, Ken-ichi; Takemi, Masayoshi; Sakamoto, Yoshifumi; Kunitsugu, Yasuhiro; Yamashita, Koji

1998-05-01

An active layer structure with 658 nm-emission at 25 degrees Celsius has been optimized in order to reduce the operating current of the laser diodes (LD) under high temperature condition. For improvement of the maximum output power and the reliability limited by mirror degradation, we have applied a zinc-diffused-type window-mirror structure which prevents the optical absorption at the mirror facet. As a result, the CW output power of 50 mW is obtained even at 80 degrees Celsius for a 650 micrometer-long window-mirror LD. In addition, the maximum light output power over 150 mW at 25 degrees Celsius has been realized without any optical mirror damage. In the aging tests, the LDs have been operating for over 2,500 - 5,000 hours under the CW condition of 30 - 50 mW at 60 degrees Celsius. The window-mirror structure also enables reliable 60 degree Celsius, 30 mW, CW operation of the LDs with 651 nm- emission at 25 degrees Celsius. Moreover, the maximum output power of around 100 mW even at 80 degrees Celsius and reliable 2,000-hour operation at 60 degrees Celsius, 70 mW have been realized for the first time by 659 nm LDs with a long cavity length of 900 micrometers.

Zeppelin NT - Measurement Platform for the Exploration of Atmospheric Chemistry and Dynamics in the Planetary Boundary Layer

Science.gov (United States)

Hofzumahaus, Andreas; Holland, Frank; Oebel, Andreas; Rohrer, Franz; Mentel, Thomas; Kiendler-Scharr, Astrid; Wahner, Andreas; Brauchle, Artur; Steinlein, Klaus; Gritzbach, Robert

2014-05-01

The planetary boundary layer (PBL) is the chemically most active and complex part of the atmosphere where freshly emitted reactive trace gases, tropospheric radicals, atmospheric oxidation products and aerosols exhibit a large variability and spatial gradients. In order to investigate the chemical degradation of trace gases and the formation of secondary pollutants in the PBL, a commercial Zeppelin NT was modified to be used as an airborne measurement platform for chemical and physical observations with high spatial resolution. The Zeppelin NT was developed by Zeppelin Luftschifftechnik (ZLT) and is operated by Deutsche Zeppelin Reederei (DZR) in Friedrichshafen, Germany. The modification was performed in cooperation between Forschungszentrum Jülich and ZLT. The airship has a length of 75 m, can lift about 1 ton of scientific payload and can be manoeuvered with high precision by propeller engines. The modified Zeppelin can carry measurement instruments mounted on a platform on top of the Zeppelin, or inside the gondola beneath the airship. Three different instrument packages were developed to investigate a. gas-phase oxidation processes involving free radicals (OH, HO2) b. formation of secondary organic aerosols (SOA) c. new particle formation (nucleation) The presentation will describe the modified airship and provide an overview of its technical performance. Examples of its application during the recent PEGASOS flight campaigns in Europe will be given.

Elevated NT-proBNP is associated with unfavorably altered plasma fibrin clot properties in atrial fibrillation.

Science.gov (United States)

Matusik, Paweł T; Matusik, Patrycja S; Kornacewicz-Jach, Zdzisława; Małecka, Barbara; Ząbek, Andrzej; Undas, Anetta

2017-09-15

Dense fibrin clot formation and hypofibrinolysis have been reported in atrial fibrillation (AF). It is unclear which factors affect fibrin clot properties in AF. We investigated plasma fibrin clot permeability (K s ), clot lysis time (CLT), endogenous thrombin potential (ETP) as well as other coagulation and fibrinolysis parameters along with N-terminal pro-B-type natriuretic peptide (NT-proBNP) in 160 AF patients (median age, 70.5years). Previous stroke (n=15; 9.4%) was associated with decreased K s (P=0.04) and longer CLT (P=0.005), together with higher antiplasmin (P=0.03) and lower tissue-type plasminogen activator (P=0.01). Lower K s (P=0.04) and tendency towards longer CLT (P=0.10) were observed in patients with a left atrium diameter>40mm. Patients with a CHA 2 DS 2 -VASc score of 3 or more (82.5%) were characterized by higher thrombin-activatable fibrinolysis inhibitor antigen (P=0.009). K s was inversely correlated with log NT-proBNP (r=-0.34, PCLT was positively correlated with log NT-proBNP (R=0.61, PCLT (the top quartile,≥109min). In AF patients prothrombotic fibrin clot properties assessed ex vivo are determined by PAI-1 and NT-proBNP and this phenotype is associated with prior ischemic stroke. Copyright © 2017 Elsevier B.V. All rights reserved.

Development of an X Window based operator's interface for a core monitoring system

International Nuclear Information System (INIS)

Vegh, J.; Huszar, J.; Laz, J.

1992-09-01

The components, functioning and programming concepts of the man-machine interface applied in an upgraded version of the core monitoring system and reactor information system VERONA for WWER-440 type nuclear power reactors, installed at the Paks Nuclear Power Plant, are described. The application of the X Window standard Graphical User Interface facilitated modular interface design and made program development easier and faster. (author) 3 refs.; 13 figs

Rigid thin windows for vacuum applications

Science.gov (United States)

Meyer, Glenn Allyn; Ciarlo, Dino R.; Myers, Booth Richard; Chen, Hao-Lin; Wakalopulos, George

1999-01-01

A thin window that stands off atmospheric pressure is fabricated using photolithographic and wet chemical etching techniques and comprises at least two layers: an etch stop layer and a protective barrier layer. The window structure also comprises a series of support ribs running the width of the window. The windows are typically made of boron-doped silicon and silicon nitride and are useful in instruments such as electron beam guns and x-ray detectors. In an electron beam gun, the window does not impede the electrons and has demonstrated outstanding gun performance and survivability during the gun tube manufacturing process.

Live histograms in moving windows

International Nuclear Information System (INIS)

Zhil'tsov, V.E.

1989-01-01

Application of computer graphics for specific hardware testing is discussed. The hardware is position sensitive detector (multiwire proportional chamber) which is used in high energy physics experiments, and real-out electronics for it. Testing program is described (XPERT), which utilises multi-window user interface. Data are represented as histograms in windows. The windows on the screen may be moved, reordered, their sizes may be changed. Histograms may be put to any window, and hardcopy may be made. Some program internals are discussed. The computer environment is quite simple: MS-DOS IBM PC/XT, 256 KB RAM, CGA, 5.25'' FD, Epson MX. 4 refs.; 7 figs

Working with Windows 7 at CERN (EN)

CERN Multimedia

CERN. Geneva

2010-01-01

Overview of new concepts and user interface changes in Windows 7 as compared with older versions of Windows: XP or Vista. Availability of Windows 7 at CERN and its integration with CERN Windows infrastructure will be discussed.

Roadmap for improving roof and façade windows in nearly zero-energy houses in Europe

DEFF Research Database (Denmark)

Skarning, Gunnlaug Cecilie Jensen; Hviid, Christian Anker; Svendsen, Svend

2016-01-01

Windows are central for the development of liveable nearly zero-energy homes and require careful consideration. Various studies have indicated that the effect of windows on energy consumption may change significantly with improved building insulation levels. Current guidelines on windows may...... comfort in nearly zero-energy houses located in the European cities Rome and Copenhagen. The aim was to identify options that can support the easy and robust design of future homes with typical use of roof and façade windows. Hourly daylight levels were calculated in DAYSIM, while space heating demand...... and operative temperatures were calculated in EnergyPlus. The results support previous findings on the limited ability of nearly zero-energy buildings to utilise solar gains. It was found that U-values are becoming increasingly important for the energy performance of windows. The paper sketches the increased...

Identification of fibroblast growth factor receptor 3 (FGFR3 as a protein receptor for botulinum neurotoxin serotype A (BoNT/A.

Directory of Open Access Journals (Sweden)

Birgitte P S Jacky

Full Text Available Botulinum neurotoxin serotype A (BoNT/A causes transient muscle paralysis by entering motor nerve terminals (MNTs where it cleaves the SNARE protein Synaptosomal-associated protein 25 (SNAP25206 to yield SNAP25197. Cleavage of SNAP25 results in blockage of synaptic vesicle fusion and inhibition of the release of acetylcholine. The specific uptake of BoNT/A into pre-synaptic nerve terminals is a tightly controlled multistep process, involving a combination of high and low affinity receptors. Interestingly, the C-terminal binding domain region of BoNT/A, HC/A, is homologous to fibroblast growth factors (FGFs, making it a possible ligand for Fibroblast Growth Factor Receptors (FGFRs. Here we present data supporting the identification of Fibroblast Growth Factor Receptor 3 (FGFR3 as a high affinity receptor for BoNT/A in neuronal cells. HC/A binds with high affinity to the two extra-cellular loops of FGFR3 and acts similar to an agonist ligand for FGFR3, resulting in phosphorylation of the receptor. Native ligands for FGFR3; FGF1, FGF2, and FGF9 compete for binding to FGFR3 and block BoNT/A cellular uptake. These findings show that FGFR3 plays a pivotal role in the specific uptake of BoNT/A across the cell membrane being part of a larger receptor complex involving ganglioside- and protein-protein interactions.

Competition analysis on the operating system market using principal component analysis

Directory of Open Access Journals (Sweden)

Brătucu, G.

2011-01-01

Full Text Available Operating system market has evolved greatly. The largest software producer in the world, Microsoft, dominates the operating systems segment. With three operating systems: Windows XP, Windows Vista and Windows 7 the company held a market share of 87.54% in January 2011. Over time, open source operating systems have begun to penetrate the market very strongly affecting other manufacturers. Companies such as Apple Inc. and Google Inc. penetrated the operating system market. This paper aims to compare the best-selling operating systems on the market in terms of defining characteristics. To this purpose the principal components analysis method was used.

Is there an additional benefit of serial NT-proBNP measurements in patients with stable chronic heart failure receiving individually optimized therapy?

Science.gov (United States)

Franke, Jennifer; Frankenstein, Lutz; Schellberg, Dieter; Bajrovic, Amer; Wolter, Jan Sebastian; Ehlermann, Philipp; Doesch, Andreas O; Nelles, Manfred; Katus, Hugo A; Zugck, Christian

2011-12-01

The role of serial NT-proBNP measurements in patients suffering from chronic systolic heart failure (CHF) who already receive individually optimized pharmacotherapy is still unresolved. NT-proBNP was assessed at baseline and at 6 months follow-up in 504 stable CHF patients treated with individually optimized pharmacotherapy. After assessment of clinical stability at 6 months, patients were followed up for at least 1 year. The combined primary endpoint was defined as death, hospitalization due to cardiac reasons or heart transplantation in 1-year follow-up. We stratified our patients according to two principles: first, a percent change of value (CV) between the first and second measurement of NT-proBNP and secondly, the transformed logarithm of NT-proBNP measured at 6 months. During the follow-up period of 1 year, 50 patients (9.9%) reached the combined primary endpoint. Stratification according to percentage CV was less accurate in predicting endpoint-free survival compared to a classification in categories of lnNT-proBNP measured at 6 months (ROC AUC = 0.615; 95% CI 0.525-0.70 vs. ROC AUC = 0.790; 95% CI 0.721-0.856, respectively). When entered into proportional hazard regression analysis, lnNT-proBNP measured at 6 months remained an independent predictor of the combined primary endpoint with an associated HR of 2.53 (95% CI 1.385-4.280). To date, this is the largest analysis of serial NT-proBNP measurements in patients with CHF receiving individually optimized medical therapy. These data suggest that a single NT-proBNP measurement after 6 months in stable clinical conditions may have higher predictive value than stratification of change in serial measurements.

Design of a 5 GHz window in a lower hybrid r.f. system

International Nuclear Information System (INIS)

Maebara, S.; Ikeda, Y.; Seki, M.; Imai, T.

1995-01-01

A new pill-box window at a frequency of 5GHz, which has an oversized length in both the axial and the radial direction, has been designed to reduce the r.f. power density and the electric field strength at the ceramics. The dimension of the new pill-box is optimized from the numerical calculation and a voltage standing-wave ratio of less than 1.02 is obtained. The r.f. power density and the maximum electric field strength are reduced to about 40% and 66% of the standard pill-box window respectively. It is evaluated that the power capability of the new oversized pill-box window by cooling edge of ceramics is more than 500kW with continuous-wave operation. ((orig.))

Mastering Windows Server 2012 R2

CERN Document Server

Minasi, Mark; Booth, Christian; Butler, Robert; McCabe, John; Panek, Robert; Rice, Michael; Roth, Stefan

2013-01-01

Check out the new Hyper-V, find new and easier ways to remotely connect back into the office, or learn all about Storage Spaces-these are just a few of the features in Windows Server 2012 R2 that are explained in this updated edition from Windows authority Mark Minasi and a team of Windows Server experts led by Kevin Greene. This book gets you up to speed on all of the new features and functions of Windows Server, and includes real-world scenarios to put them in perspective. If you're a system administrator upgrading to, migrating to, or managing Windows Server 2012 R2, find what you need to

NT-pro-BNP levels in patients with acute pulmonary embolism are correlated to right but not left ventricular volume and function.

Science.gov (United States)

Pasha, Sharif M; Klok, Frederikus A; van der Bijl, Noortje; de Roos, Albert; Kroft, Lucia J M; Huisman, Menno V

2012-08-01

N-terminal pro-Brain Natriuretic Peptide (NT-pro-BNP) is primarily secreted by left ventricular (LV) stretch and wall tension. Notably, NT-pro-BNP is a prognostic marker in acute pulmonary embolism (PE), which primarily stresses the right ventricle (RV). We sought to evaluate the relative contribution of the RV to NT-pro-BNP levels during PE. A post-hoc analysis of an observational prospective outcome study in 113 consecutive patients with computed tomography (CT)-proven PE and 226 patients in whom PE was clinically suspected but ruled out by CT. In all patients RV and LV function was established by assessing ECG-triggered-CT measured ventricular end-diastolic-volumes and ejection fraction (EF). NT-pro-BNP was assessed in all patients. The correlation between RV and LV end-diastolic-volumes and systolic function was evaluated by multiple linear regression corrected for known confounders. In the PE cohort increased RVEF (β-coefficient (95% confidence interval [CI]) -0.044 (± -0.011); p<0.001) and higher RV end-diastolic-volume (β-coefficient 0.005 (± 0.001); p<0.001) were significantly correlated to NT-pro-BNP, while no correlation was found with LVEF (β-coefficient 0.005 (± 0.010); p=0.587) and LV end-diastolic-volume (β-coefficient -0.003 (± 0.002); p=0.074). In control patients without PE we found a strong correlation between NT-pro-BNP levels and LVEF (β-coefficient -0.027 (± -0.006); p<0.001) although not LV end-diastolic-volume (β-coefficient 0.001 (± 0.001); p=0.418). RVEF (β-coefficient -0.002 (± -0.006); p=0.802) and RV end-diastolic-volume (β-coefficient <0.001 (± 0.001); p=0.730) were not correlated in patients without PE. In PE patients, lower RVEF and higher RV end-diastolic-volume were significantly correlated to NT-pro-BNP levels as compared to control patients without PE. These observations provide pathophysiological ground for the well-known prognostic value of NT-pro-BNP in acute PE.

Microsoft Windows Intune 20 Quickstart Administration

CERN Document Server

Overton, David

2012-01-01

This book is a concise and practical tutorial that shows you how to plan, set up and maintain Windows Intune and manage a group of PCs. If you are an administrator or partner who wants to plan, set up and maintain Windows Intune and manage a group of PCs then this book is for you . You should have a basic understanding of Windows administration, however, knowledge of Windows Intune would not be required.

Transforming the market for residential windows: design considerations for DOE's Efficient Window Collaborative

Energy Technology Data Exchange (ETDEWEB)

Eto, J.; Arasteh, D.; Selkowitz, S.

1998-08-01

Market adoption of recent, commercially available technological advances that improve the energy performance of windows will lead to immediate economic and energy savings benefits to the nation. This paper is a scoping study intended to inform the design of a major DOE initiative to accelerate market adoption of these windows in the residential sector. We describe the structure of the US residential window market and the interests of the various market players. We then briefly review five recent market transformation initiatives. Finally, we summarize our findings in a list of considerations we believe will be important for the DOE's initiative to transform the US residential window market.

Travailler avec Windows 7 au CERN

CERN Multimedia

CERN. Geneva

2011-01-01

Vue d'ensemble des nouveaux concepts et des changements dans l'interface utilisateur survenus dans Windows 7 depuis les versions antérieures de Windows (XP ou Vista). Le plan de migration à Windows 7 sera aussi débattu.

Travailler avec Windows 7 au CERN

CERN Multimedia

CERN. Geneva

2012-01-01

Vue d'ensemble des nouveaux concepts et des changements dans l'interface utilisateur survenus dans Windows 7 depuis les versions antérieures de Windows (XP ou Vista). Le plan de migration à Windows 7 sera aussi débattu.

Windows VPN Set Up | High-Performance Computing | NREL

Science.gov (United States)

Windows VPN Set Up Windows VPN Set Up To set up Windows for HPC VPN, here are the steps: Download your version of Windows. Note: We only support the the Endian Connect software when connecting to the a VPN connection to the HPC systems. Windows Version Connect App Windows 10

Frame approximation of pseudo-inverse operators

DEFF Research Database (Denmark)

Christensen, Ole

2001-01-01

Let T denote an operator on a Hilbert space (H, [.,.]), and let {f(i)}(i=1)(infinity) be a frame for the orthogonal complement of the kernel NT. We construct a sequence of operators {Phi (n)} of the form Phi (n) (.) = Sigma (n)(i=1) [., g(t)(n)]f(i) which converges to the psuedo-inverse T+ of T i...... in the strong operator topology as n --> infinity. The operators {Phi (n)} can be found using finite-dimensional methods. We also prove an adaptive iterative version of the result. (C) 2001 Academic Press....

TiO2-NT electrodes modified with Ag and diamond like carbon (DLC) for hydrogen production by alkaline water electrolysis

Science.gov (United States)

Baran, Evrim; Baz, Zeynep; Esen, Ramazan; Yazici Devrim, Birgül

2017-10-01

In present work, the two-step anodization technique was applied for synthesis of TiO2 nanotube (NT). Silver and diamond like carbon (DLC) were coated on the surface of as prepared TiO2-NT using chemical reduction method and MW ECR plasma system. The morphology, composition and structure of the electrodes were examined by field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD). The results showed that Ag nanoparticles, having size in the range of 48-115 nm, are evenly distributed on the top, inside and outside surface of TiO2-NT and when DLC was coated on the surface of TiO2-NT and TiO2-NT-Ag, the top of nanotubes were partially open and the pore diameter of hexagonal structure decreased from 165 nm to of 38-80 nm. On the other hand, the microhardness test and contact angle measurements revealed that additions of Ag and diamond like carbon have a positive effect on the mechanical properties of TiO2-NT film. The electrocatalytic properties of the electrodes towards the hydrogen evolution reaction (HER) were investigated by the electrochemical measurements recorded in 1 M KOH solution. In addition, long-term durability of electrodes towards HER and the energy consumption of alkaline electrolysis were investigated. The energy requirement showed that while the deposition of silver provides approximately 14.95% savings of the energy consumption, the DLC coating causes increase in energy consumption.

Extraction and inhibition of enzymatic activity of botulinum neurotoxins/A1, /A2, and /A3 by a panel of monoclonal anti-BoNT/A antibodies.

Directory of Open Access Journals (Sweden)

Suzanne R Kalb

Full Text Available Botulinum neurotoxins (BoNTs are extremely potent toxins that are capable of causing death or respiratory failure leading to long-term intensive care. Treatment includes serotype-specific antitoxins, which must be administered early in the course of the intoxication. Rapidly determining human exposure to BoNT is an important public health goal. In previous work, our laboratory focused on developing Endopep-MS, a mass spectrometry-based endopeptidase method for detecting and differentiating BoNT/A-G serotypes in buffer and BoNT/A, /B, /E, and /F in clinical samples. We have previously reported the effectiveness of antibody-capture to purify and concentrate BoNTs from complex matrices, such as clinical samples. Because some antibodies inhibit or neutralize the activity of BoNT, the choice of antibody with which to extract the toxin is critical. In this work, we evaluated a panel of 16 anti-BoNT/A monoclonal antibodies (mAbs for their ability to inhibit the in vitro activity of BoNT/A1, /A2, and /A3 complex as well as the recombinant LC of A1. We also evaluated the same antibody panel for the ability to extract BoNT/A1, /A2, and /A3. Among the mAbs, there were significant differences in extraction efficiency, ability to extract BoNT/A subtypes, and inhibitory effect on BoNT catalytic activity. The mAbs binding the C-terminal portion of the BoNT/A heavy chain had optimal properties for use in the Endopep-MS assay.

The Nicest way to migrate your Windows computer ( The Windows 2000 Migration Task Force)

CERN Document Server

2001-01-01

With Windows 2000, CERN users will discover a more stable and reliable working environment and will have access to all the latest applications. The Windows 2000 Migration Task Force - a representative from each division.

Peliohjelmointi Windows Phone 8:lle

OpenAIRE

Bäckström, Toni

2014-01-01

Tässä insinöörityössä tutustutaan Windows Phone 8 -mobiilikäyttöjärjestelmään peliohjelmoijan näkökulmasta. Työn tavoitteena oli erityisesti esitellä Microsoftin itse kehittämiä XNA- ja DirectX-peliohjelmointikirjastoja teoriassa ja käytännössä. Työn aluksi käydään läpi hieman Windows Phonen historiaa ja yleisesti kehittämistä Windows Phone 8:lle. Tämän jälkeen luodaan katsaus Windows Phone 8:aan pelialustana. Työn suurin osuus on XNA:n ja DirectX:n esittely teoriassa; kummastakin men...

Conversion from 8800 to 8800PC - Evaluation and experience

International Nuclear Information System (INIS)

Miner, A.E.; Lawson, B.J.

1998-01-01

Though a final version of the software is pending the 8800PC operating system host computer is a welcomed change from the old Digital (DEC) host computer. The 8800PC host computer uses the Windows NT operating system and has proven to be very user friendly. Descriptive window messages replace the cryptic coding of the DEC host. Though numerous electrical components were replaced, system calibration remained constant. Calibrated Thermoluminescent (TL) output from a randomly selected 8815 field card was measured before and after the upgrade. The % difference, when comparing calibrated output from an upgraded reader to the non upgraded reader, ranged from 0.2 to 3%. The most disappointing aspect of the upgrade experience was the lag time between hardware installation and software completion

Is N.D. and N.T. v. Spain the new Hirsi?

NARCIS (Netherlands)

Pijnenburg, Annick

2017-01-01

On 3 October the Third Chamber of the European Court of Human Rights published its judgment N.D. and N.T. v. Spain, which concerns Spain’s pushback policy in Melilla. It found a violation of Article 4 of Protocol 4 (prohibition of collective expulsions of aliens) and of Article 13 (right to an

Solar Heat Gain Coefficient (SHGC) | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Thin Film & Deposition Systems (Windows)

Data.gov (United States)

Federal Laboratory Consortium — Coating Lab: Contains chambers for growing thin film window coatings. Plasma Applications Coating Lab: Contains chambers for growing thin film window coatings. Solar...

Mortality and preoperative cardiac function in vascular amputees : an N-terminal pro-brain natriuretic peptide (NT-proBNP) pilot study

NARCIS (Netherlands)

Riemersma, Marcel; Dijkstra, Pieter U.; van Veldhuisen, Dirk Jan; Muskiet, Frits A. J.; van den Dungen, Jan A. M. M.; Geertzen, Jan H. B.

Objective: To determine preoperative ventricular function in vascular amputees by measuring N-terminal pro-brain natriuretic peptide (NT-proBNP) and to analyse the relationship between NT-proBNP levels and 30-day postoperative mortality. Design: Prospective pilot study. Subjects and methods: In 19

Grønt regnskab for boligområder

DEFF Research Database (Denmark)

Jensen, O.M.

Grønne regnskaber har vundet indpas i virksomheder, kommuner og boligområder. Med denne rapport foreligger der en model og en metode for opstilling af et grønt regnskab, der kan anvendes på alle typer af boliger, boligbebyggelser og boligområder. Et tilhørende regneark kan hjemtages på SBI´s hjem......´s hjemmeside 'www.sbi.dk', eller det kan opstilles ved hjælp af anvisningerne i rapporten. Rapporten henvender sig til alle, der arbejder med energiledelse, boligforvaltning, økologisk boligbyggeri, byfornyelse, miljødebat og Agenda 21-arbejde....

Imaging windows for long-term intravital imaging

Science.gov (United States)

Alieva, Maria; Ritsma, Laila; Giedt, Randy J; Weissleder, Ralph; van Rheenen, Jacco

2014-01-01

Intravital microscopy is increasingly used to visualize and quantitate dynamic biological processes at the (sub)cellular level in live animals. By visualizing tissues through imaging windows, individual cells (e.g., cancer, host, or stem cells) can be tracked and studied over a time-span of days to months. Several imaging windows have been developed to access tissues including the brain, superficial fascia, mammary glands, liver, kidney, pancreas, and small intestine among others. Here, we review the development of imaging windows and compare the most commonly used long-term imaging windows for cancer biology: the cranial imaging window, the dorsal skin fold chamber, the mammary imaging window, and the abdominal imaging window. Moreover, we provide technical details, considerations, and trouble-shooting tips on the surgical procedures and microscopy setups for each imaging window and explain different strategies to assure imaging of the same area over multiple imaging sessions. This review aims to be a useful resource for establishing the long-term intravital imaging procedure. PMID:28243510

A novel configurable VLSI architecture design of window-based image processing method

Science.gov (United States)

Zhao, Hui; Sang, Hongshi; Shen, Xubang

2018-03-01

Most window-based image processing architecture can only achieve a certain kind of specific algorithms, such as 2D convolution, and therefore lack the flexibility and breadth of application. In addition, improper handling of the image boundary can cause loss of accuracy, or consume more logic resources. For the above problems, this paper proposes a new VLSI architecture of window-based image processing operations, which is configurable and based on consideration of the image boundary. An efficient technique is explored to manage the image borders by overlapping and flushing phases at the end of row and the end of frame, which does not produce new delay and reduce the overhead in real-time applications. Maximize the reuse of the on-chip memory data, in order to reduce the hardware complexity and external bandwidth requirements. To perform different scalar function and reduction function operations in pipeline, this can support a variety of applications of window-based image processing. Compared with the performance of other reported structures, the performance of the new structure has some similarities to some of the structures, but also superior to some other structures. Especially when compared with a systolic array processor CWP, this structure at the same frequency of approximately 12.9% of the speed increases. The proposed parallel VLSI architecture was implemented with SIMC 0.18-μm CMOS technology, and the maximum clock frequency, power consumption, and area are 125Mhz, 57mW, 104.8K Gates, respectively, furthermore the processing time is independent of the different window-based algorithms mapped to the structure

Mechanical reliability of current alumina and beryllia ceramics used in microwave windows for gyrotrons

International Nuclear Information System (INIS)

Becher, P.F.; Ferber, M.K.

1983-02-01

The mechanical reliability was evaluated for the alumina and beryllia ceramics now used as microwave windows in the high-power (greater than or equal to 200 kW) high-frequency (greater than or equal to 60 GHz) gyrotron tubes being developed for plasma heating in fusion systems. Analysis of the stresses generated in the various window configurations and tube operating conditions indicated that significant tensile stresses are generated in the ceramic window by dielectric heating. As a result, we characterized the static and dynamic fatigue behavior and the inert strength distributions for these two ceramics (i.e., fatigue studies included the behavior in the fluorocarbon fluid used for window cooling at 22 and 48 0 C and in both air (65% relative humidity) and distilled water at 22 0 C. These data were then analyzed in order to construct reliability diagrams for these materials

Diagnostic and prognostic value of N-terminal pro B-type natriuretic peptide (NT-proBNP) in patients with chronic aortic regurgitation.

Science.gov (United States)

Weber, Michael; Hausen, Michael; Arnold, Roman; Moellmann, Helge; Nef, Holger; Elsaesser, Albrecht; Mitrovic, Vesselin; Hamm, Christian

2008-07-21

BNP and its N-terminal fragment NT-proBNP have proven to be of diagnostic and prognostic value in patients with valvular aortic stenosis. Data regarding those biomarkers in patients with chronic aortic regurgitation (AR) are sparse. Thus it was the aim of the present study to evaluate the diagnostic and the long term prognostic value of NT-proBNP in patients presenting with AR. This study included 60 patients with isolated AR of varying severity (AR I mild, AR II moderate and AR III severe) and preserved left ventricular function. Patients were followed over a median period of 824 (770-921) days. NT-proBNP at baseline was related to disease severity and to functional status (161 (70-456) pg/ml in AR I, 226 (100-666) pg/ml in AR II and 1268 (522-5446) pg/ml in AR III (p=0.003)). Patients (n=6) experiencing an adverse event had higher NT-proBNP values at baseline as event free survivors (1271 (613-2992) pg/ml vs. 215 (92-534) pg/ml; p=0.034). The AUC of the ROC curve for NT-proBNP as a predictor for an adverse event was 0.76 (pvalue of 602 pg/ml. Consequently, in Kaplan-Meier analysis NT-proBNP values dichotomised at this cut-off were able to discriminate patients with an adverse outcome in the entire study group (Log rank 9.98, p=0.0016) and even better in the conservative group (Log rank 26.92, p<0.001). NT-proBNP is linked to disease severity in patients with chronic aortic regurgitation reflecting hemodynamic stress due to volume overload. It provides prognostic information for the clinical outcome and thus might be a useful biomarker for risk stratification.

Vacuum window glazings for energy-efficient buildings

Energy Technology Data Exchange (ETDEWEB)

Benson, D.K.; Smith, L.K.; Tracy, C.E.; Potter, T.; Christensen, C. (Solar Energy Research Inst., Golden, CO (USA)); Soule, D.E. (Western Illinois Univ., Macomb, IL (USA))

1990-05-01

The technical feasibility of a patented, laser-welded, evacuated insulating window was studied. The window has two edge-sealed sheets of glass separated by 0.5-mm glass spheres spaced 30 mm apart in a regular array. A highly insulating frame is required and several designs were analyzed. The vacuum window's combination of high solar transmittance and low thermal conductance makes it superior to many other windows in cold climates. In the US Pacific Northwest, the vacuum window could save about 6 MJ of heating energy annually per square meter of window in comparison to conventional, double-glazed windows. A large, vacuum laser-welding facility was designed and installed to conduct glass welding experiments and to fabricate full-sized vacuum windows. Experiments confirmed the feasibility of laser-sealing glass in vacuum but identified two difficulties. Under some circumstances, bubbles of dissolved gases form during welding and weaken the seal. Glass also vaporizes and contaminates the laser beam steering mirror. A novel moving metal foil mirror was developed to circumvent the contamination problem, but it has not yet been used to complete welding experiments and fabricate full-sized vacuum windows. 63 refs., 53 figs., 19 tabs.

New Liquid Crystal Smart Window and its Production Process (SmartWin II)

DEFF Research Database (Denmark)

Jensen, Karsten Ingerslev; Kristiansen, Finn Harken; Schultz, Jørgen Munthe

2005-01-01

window: 1) with sufficient area glazing to meet the market, 2) using a technology which supplies the glazing with three operating modes: 2a) a reflective mode limiting the glazing overheating, 2b) a transparent mode with an excellent transparency, 2c) a scattering mode having a grey scale, 3) for which...... large market potential for this technology. Conception and realisation of a pre-industrial machine for manufacturing smart windows were obtained. By means of this pre-industrial machine, the sample surface area was progressive increased from lab-scale (approx. 10 cm sq.) up to 60 cm x 80 cm at Mid...

Analysis of oil-pipeline distribution of multiple products subject to delivery time-windows

Science.gov (United States)

Jittamai, Phongchai

This dissertation defines the operational problems of, and develops solution methodologies for, a distribution of multiple products into oil pipeline subject to delivery time-windows constraints. A multiple-product oil pipeline is a pipeline system composing of pipes, pumps, valves and storage facilities used to transport different types of liquids. Typically, products delivered by pipelines are petroleum of different grades moving either from production facilities to refineries or from refineries to distributors. Time-windows, which are generally used in logistics and scheduling areas, are incorporated in this study. The distribution of multiple products into oil pipeline subject to delivery time-windows is modeled as multicommodity network flow structure and mathematically formulated. The main focus of this dissertation is the investigation of operating issues and problem complexity of single-source pipeline problems and also providing solution methodology to compute input schedule that yields minimum total time violation from due delivery time-windows. The problem is proved to be NP-complete. The heuristic approach, a reversed-flow algorithm, is developed based on pipeline flow reversibility to compute input schedule for the pipeline problem. This algorithm is implemented in no longer than O(T·E) time. This dissertation also extends the study to examine some operating attributes and problem complexity of multiple-source pipelines. The multiple-source pipeline problem is also NP-complete. A heuristic algorithm modified from the one used in single-source pipeline problems is introduced. This algorithm can also be implemented in no longer than O(T·E) time. Computational results are presented for both methodologies on randomly generated problem sets. The computational experience indicates that reversed-flow algorithms provide good solutions in comparison with the optimal solutions. Only 25% of the problems tested were more than 30% greater than optimal values and

Windows Server 2012 R2 administrator cookbook

CERN Document Server

Krause, Jordan

2015-01-01

This book is intended for system administrators and IT professionals with experience in Windows Server 2008 or Windows Server 2012 environments who are looking to acquire the skills and knowledge necessary to manage and maintain the core infrastructure required for a Windows Server 2012 and Windows Server 2012 R2 environment.

Transfection using hydroxyapatite nanoparticles in the inner ear via an intact round window membrane in chinchilla

International Nuclear Information System (INIS)

Wu Xuewen; Ding Dalian; Jiang Haiyan; XingXiaowei; Huang, Suping; Liu Hong; Chen Zhedong; Sun Hong

2012-01-01

Hydroxyapatite nanoparticles (nHAT) are known to have excellent biocompatibility, and have attracted increasing attention as new candidates of non-viral vectors for gene therapy. In our previous studies, nHAT carrying a therapeutic gene and a reporter gene were successfully transfected into the spiral ganglion neurons in the inner ear of guinea pigs in vivo as well as in the cultured cell lines, although the transfection efficiencies were never higher than 30%. In this study, the surface modification of nHAT with polyethylenimine (PEI) was made (PEI–nHAT, diameter = 73.09 ± 27.32 nm) and a recombinant plasmid carrying enhanced green fluorescent protein (EGFP) gene and neurotrophin-3 (NT-3) gene was constructed as pEGFPC2–NT3. The PEI modified nHAT and the recombinant plasmid was then connected to form the nHAT-based vector–gene complex (PEI–nHAT–pEGFPC2–NT3). This complex was then placed onto the intact round window membranes of the chinchillas for inner ear transfection. Auditory brainstem response (ABR) was tested to evaluate auditory function. Green fluorescence of EGFP was observed using confocal microscopy 48 h after administering vector–gene complexes. There was no significant threshold shift in tone burst-evoked ABR at any tested frequency. Abundant, condensed green fluorescence was found in dark cells on both sides of the crista and around the macula of the utricle. Scattered EGFP signals were also detected in vestibular hair cells, some Schwann cells in the cochlear spiral ganglion region, some outer pillar cells in the organ of Corti, and a few cells in the stria vascularis. The density of green fluorescence-marked cells was obviously higher in the vestibular dark cell area than in other areas of the inner ear, suggesting that vestibular dark cells may have the ability to actively engulf the nHAT-based vector–gene complexes. Considering the high transfection efficiency in the vestibular system, PEI–nHAT may be a potential vector for

The sonic window: second generation results

Science.gov (United States)

Walker, William F.; Fuller, Michael I.; Brush, Edward V.; Eames, Matthew D. C.; Owen, Kevin; Ranganathan, Karthik; Blalock, Travis N.; Hossack, John A.

2006-03-01

Medical Ultrasound Imaging is widely used clinically because of its relatively low cost, portability, lack of ionizing radiation, and real-time nature. However, even with these advantages ultrasound has failed to permeate the broad array of clinical applications where its use could be of value. A prime example of this untapped potential is the routine use of ultrasound to guide intravenous access. In this particular application existing systems lack the required portability, low cost, and ease-of-use required for widespread acceptance. Our team has been working for a number of years to develop an extremely low-cost, pocket-sized, and intuitive ultrasound imaging system that we refer to as the "Sonic Window." We have previously described the first generation Sonic Window prototype that was a bench-top device using a 1024 element, fully populated array operating at a center frequency of 3.3 MHz. Through a high degree of custom front-end integration combined with multiplexing down to a 2 channel PC based digitizer this system acquired a full set of RF data over a course of 512 transmit events. While initial results were encouraging, this system exhibited limitations resulting from low SNR, relatively coarse array sampling, and relatively slow data acquisition. We have recently begun assembling a second-generation Sonic Window system. This system uses a 3600 element fully sampled array operating at 5.0 MHz with a 300 micron element pitch. This system extends the integration of the first generation system to include front-end protection, pre-amplification, a programmable bandpass filter, four sample and holds, and four A/D converters for all 3600 channels in a set of custom integrated circuits with a combined area smaller than the 1.8 x 1.8 cm footprint of the transducer array. We present initial results from this front-end and present benchmark results from a software beamformer implemented on the Analog Devices BF-561 DSP. We discuss our immediate plans for further

The development of Windows based control system for the tele-robotics

International Nuclear Information System (INIS)

Kim, Byung Soo; Kim, Seung Ho; Seo, Yong Chil; Kim, Ki Ho; Hwang, Suk Yeoung; Kim, Chang Hoi; Jung, Seung Ho; Lee, Young Kwang

1998-03-01

The WSCS (Windows-based Supervisory Control System) has been developed for the efficient control of the mobile robot in the hazardous area, such as reactor surroundings of HPWR (Heavy Pressurized Water Reactor). The WSCS is basically computer program which consists windows menu-program, socket-based communication program, force reflection joystick program, and OpenGL-based 3D graphic program. Also, the WSCS includes the force control algorithm of a master control device ( in this case, joystick) for the enhanced operability. To evaluate the effectiveness of the designed WSCS and the force reflection control algorithm, a series of experiments has been made in such a way that human operators command the desired motion of robot by manipulating the joystick in the virtual environment. As a result, it was proven that the designed WSCS is very easy-to-use and effective. Also, the developed force reflection algorithm is more efficient than that of general tele-operation, even though there are some difference in human dexterity. In near future, the WSCS will be applied in the next version of KAEROT. (author). 11 refs., 14 tabs., 1 fig

Nuclear power plant operating personnel training for normal and accident situations

International Nuclear Information System (INIS)

Dufrene, C.

1995-01-01

Training system of reactor operating staff in France for maximum safety is discussed. The structure of the training program consists of three levels, initial training in each aspect of operations job functions, with systematic refresher training sessions; the principles at global team skills; the range of skills required for unit operation. (N.T.). 1 fig

Exploiting the X-Window environment to expand the number, reach, and usefulness of Fermilab accelerator control consoles

International Nuclear Information System (INIS)

Cahill, K.; Smedinghoff, J.

1992-01-01

The Fermilab accelerator operator workstation of choice is now the Digital VAX station running VMS and X-Window software. This new platform provides an easy to learn programming environment while support routines are expanding in number and power. The X-Window environment is exploited to provide remote consoles to users across long haul networks and to support multiple consoles on a single workstation. The integration of imaging systems, local datalogging, commercial and Physics community's software, and development facilities on the operator workstation adds functionality to the system. The locally engineered knob/pointer/keyboard interface solves the multiple keyboard and mouse problems of a multi-screen console. This paper will address these issues of Fermilab's accelerator operator workstations. (author)

Switchable Materials for Smart Windows.

Science.gov (United States)

Wang, Yang; Runnerstrom, Evan L; Milliron, Delia J

2016-06-07

This article reviews the basic principles of and recent developments in electrochromic, photochromic, and thermochromic materials for applications in smart windows. Compared with current static windows, smart windows can dynamically modulate the transmittance of solar irradiation based on weather conditions and personal preferences, thus simultaneously improving building energy efficiency and indoor human comfort. Although some smart windows are commercially available, their widespread implementation has not yet been realized. Recent advances in nanostructured materials provide new opportunities for next-generation smart window technology owing to their unique structure-property relations. Nanomaterials can provide enhanced coloration efficiency, faster switching kinetics, and longer lifetime. In addition, their compatibility with solution processing enables low-cost and high-throughput fabrication. This review also discusses the importance of dual-band modulation of visible and near-infrared (NIR) light, as nearly 50% of solar energy lies in the NIR region. Some latest results show that solution-processable nanostructured systems can selectively modulate the NIR light without affecting the visible transmittance, thus reducing energy consumption by air conditioning, heating, and artificial lighting.

Small-molecule quinolinol inhibitor identified provides protection against BoNT/A in mice.

Directory of Open Access Journals (Sweden)

Padma Singh

Full Text Available Botulinum neurotoxins (BoNTs, etiological agents of the life threatening neuroparalytic disease botulism, are the most toxic substances currently known. The potential for the use as bioweapon makes the development of small-molecule inhibitor against these deadly toxins is a top priority. Currently, there are no approved pharmacological treatments for BoNT intoxication. Although an effective vaccine/immunotherapy is available for immuno-prophylaxis but this cannot reverse the effects of toxin inside neurons. A small-molecule pharmacological intervention, especially one that would be effective against the light chain protease, would be highly desirable. Similarity search was carried out from ChemBridge and NSC libraries to the hit (7-(phenyl(8-quinolinylaminomethyl-8-quinolinol; NSC 84096 to mine its analogs. Several hits obtained were screened for in silico inhibition using AutoDock 4.1 and 19 new molecules selected based on binding energy and Ki. Among these, eleven quinolinol derivatives potently inhibited in vitro endopeptidase activity of botulinum neurotoxin type A light chain (rBoNT/A-LC on synaptosomes isolated from rat brain which simulate the in vivo system. Five of these inhibitor molecules exhibited IC(50 values ranging from 3.0 nM to 10.0 µM. NSC 84087 is the most potent inhibitor reported so far, found to be a promising lead for therapeutic development, as it exhibits no toxicity, and is able to protect animals from pre and post challenge of botulinum neurotoxin type A (BoNT/A.

A window on urban sustainability

International Nuclear Information System (INIS)

Stigt, Rien van; Driessen, Peter P.J.; Spit, Tejo J.M.

2013-01-01

Sustainable urban development requires the integration of environmental interests in urban planning. Although various methods of environmental assessment have been developed, plan outcomes are often disappointing due to the complex nature of decision-making in urban planning, which takes place in multiple arenas within multiple policy networks involving diverse stakeholders. We argue that the concept of ‘decision windows’ can structure this seemingly chaotic chain of interrelated decisions. First, explicitly considering the dynamics of the decision-making process, we further conceptualized decision windows as moments in an intricate web of substantively connected deliberative processes where issues are reframed within a decision-making arena, and interests may be linked within and across arenas. Adopting this perspective in two case studies, we then explored how decision windows arise, which factors determine their effectiveness and how their occurrence can be influenced so as to arrive at more sustainable solutions. We conclude that the integration of environmental interests in urban planning is highly dependent on the ability of the professionals involved to recognize and manipulate decision windows. Finally, we explore how decision windows may be opened. -- Highlights: • Decision-making about sustainable urban development occurs in networks. • The concept of ‘decision windows’ was further elaborated. • Decision windows help understand how environmental interests enter decision-making. • Decision windows can, to some extent, be influenced

A window on urban sustainability

Energy Technology Data Exchange (ETDEWEB)

Stigt, Rien van, E-mail: rien.vanstigt@hu.nl [Research Center for Technology and Innovation, Utrecht University of Applied Sciences, P.O. Box 182, 3500 AD Utrecht (Netherlands); Driessen, Peter P.J., E-mail: p.driessen@uu.nl [Copernicus Institute of Sustainable Development, Faculty of Geosciences, Utrecht University, P.O. Box 80.115, 3508 TC Utrecht (Netherlands); Spit, Tejo J.M., E-mail: T.J.M.Spit@uu.nl [Department of Human Geography and Spatial Planning, Faculty of Geosciences, Utrecht University, P.O. Box 80.115, 3508 TC Utrecht (Netherlands)

2013-09-15

Sustainable urban development requires the integration of environmental interests in urban planning. Although various methods of environmental assessment have been developed, plan outcomes are often disappointing due to the complex nature of decision-making in urban planning, which takes place in multiple arenas within multiple policy networks involving diverse stakeholders. We argue that the concept of ‘decision windows’ can structure this seemingly chaotic chain of interrelated decisions. First, explicitly considering the dynamics of the decision-making process, we further conceptualized decision windows as moments in an intricate web of substantively connected deliberative processes where issues are reframed within a decision-making arena, and interests may be linked within and across arenas. Adopting this perspective in two case studies, we then explored how decision windows arise, which factors determine their effectiveness and how their occurrence can be influenced so as to arrive at more sustainable solutions. We conclude that the integration of environmental interests in urban planning is highly dependent on the ability of the professionals involved to recognize and manipulate decision windows. Finally, we explore how decision windows may be opened. -- Highlights: • Decision-making about sustainable urban development occurs in networks. • The concept of ‘decision windows’ was further elaborated. • Decision windows help understand how environmental interests enter decision-making. • Decision windows can, to some extent, be influenced.

Travailler avec Windows 7 au CERN (FR)

CERN Multimedia

CERN. Geneva

2010-01-01

Vue d'ensemble des nouveaux concepts et des changements dans l'interface utilisateur survenus dans Windows 7 depuis les versions antérieures de Windows (XP ou Vista). La mise à disposition de Windows 7 au CERN et son intégration dans l’infrastructure de Windows au CERN seront présentées.

30 CFR 18.30 - Windows and lenses.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Windows and lenses. 18.30 Section 18.30 Mineral... § 18.30 Windows and lenses. (a) MSHA may waive testing of materials for windows or lenses except headlight lenses. When tested, material for windows or lenses shall meet the test requirements prescribed in...

49 CFR 238.114 - Rescue access windows.

Science.gov (United States)

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Rescue access windows. 238.114 Section 238.114... § 238.114 Rescue access windows. (a) Number and location. Except as provided in paragraph (a)(1)(ii) of... rescue access windows. At least one rescue access window shall be located in each side of the car...

Mastering Windows Server 2008 Networking Foundations

CERN Document Server

Minasi, Mark; Mueller, John Paul

2011-01-01

Find in-depth coverage of general networking concepts and basic instruction on Windows Server 2008 installation and management including active directory, DNS, Windows storage, and TCP/IP and IPv4 networking basics in Mastering Windows Server 2008 Networking Foundations. One of three new books by best-selling author Mark Minasi, this guide explains what servers do, how basic networking works (IP basics and DNS/WINS basics), and the fundamentals of the under-the-hood technologies that support staff must understand. Learn how to install Windows Server 2008 and build a simple network, security co

Microsoft Windows 7 Administration Instant Reference

CERN Document Server

Panek, William

2010-01-01

An on-the-spot reference for Windows 7 administrators. Hundreds of thousands of IT administrators, network administrators, and IT support technicians work daily with Windows 7. This well-organized, portable reference covers every facet of Windows 7, providing no-nonsense instruction that is readily accessible when you need it. Designed for busy administrators, it features thumb tabs and chapter outlines to make answers easy to find.: Windows 7 administrative and support personnel need quick answers to situations they confront each day; this Instant Reference is designed to provide information,

Production management of window handles

Directory of Open Access Journals (Sweden)

Manuela Ingaldi

2014-12-01

Full Text Available In the chapter a company involved in the production of aluminum window and door handles was presented. The main customers of the company are primarily companies which produce PCV joinery and wholesalers supplying these companies. One chosen product from the research company - a single-arm pin-lift window handle - was described and its production process depicted technologically. The chapter also includes SWOT analysis conducted in the research company and the value stream of the single-arm pin-lift window handle.

Bronchoplastic operations for lung cancer

International Nuclear Information System (INIS)

Cicenas, S.; Naujokaitis, P.; Jackevicius, A. and others

2002-01-01

Objective of our work was to evaluate efficacy of bronchoplastic operations for lung cancer and time to progression in combined treatment. From 1997 till 2001, 57pts were operated for early I-IIB stages of lung cancer. Operations were: tracheal resections in 3pts (5.2%), window right pneumonectomies in 5pts (8.7%), window left pneumonectomies in 2pts (3.5%), window right upper lobe in 22pts (38.5%), bifurcation resections 2pts (3.5%), sleeve right upper lobe resections 7pts (12.2%), sleeve left upper lobe resections in 11pts (19.2%). We had complications: in 7pts (12.2%) suture failure, 26pts (45.6%) obstructive pneumonia, 3pts (5.2%) kinking of anastomosis, 2pts (3.7%) bronchial bleeding, 6pts (10.5%) covered bronchial fistulas, 5pts (8.7%) died after operations. 32pts (56%) underwent radiation after surgery, 13pts (22.8%) radiation and chemotherapy. Three-year survival was in 82.4% (47pts), in 10pts (17.4%) disease progressed. Bronchoplastic operations are sufficient for early lung cancer treatment. Three-year was in survival 82.7% of pts. Seventeen percent of patients failed after combined treatment. (author)

Evaluation of Energy Efficiency Performance of Heated Windows

Science.gov (United States)

Jammulamadaka, Hari Swarup

The study about the evaluation of the performance of the heated windows was funded by the WVU Research Office as a technical assistance award at the 2014 TransTech Energy Business Development Conference to the Green Heated Glass company/project owned by Frank Dlubak. The award supports a WVU researcher to conduct a project important for commercialization. This project was awarded to the WVU Industrial Assessment Center in 2015. The current study attempted to evaluate the performance of the heated windows by developing an experimental setup to test the window at various temperatures by varying the current input to the window. The heated double pane window was installed in an insulated box. A temperature gradient was developed across the window by cooling one side of the window using gel based ice packs. The other face of the window was heated by passing current at different wattages through the window. The temperature of the inside and outside panes, current and voltage input, room and box temperature were recorded, and used to calculate the apparent R-value of the window when not being heated vs when being heated. It has been concluded from the study that the heated double pane window is more effective in reducing heat losses by as much as 50% than a non-heated double pane window, if the window temperature is maintained close to the room temperature. If the temperature of the window is much higher than the room temperature, the losses through the window appear to increase beyond that of a non-heated counterpart. The issues encountered during the current round of experiments are noted, and recommendations provided for future studies.

NT-pro-BNP is associated with inducible myocardial ischemia in mildly symptomatic type 2 diabetic patients.

Science.gov (United States)

Wiersma, Jacobijne J; van der Zee, P Marc; van Straalen, Jan P; Fischer, Johan C; van Eck-Smit, Berthe L F; Tijssen, Jan G P; Trip, Mieke D; Piek, Jan J; Verberne, Hein J

2010-11-19

Baseline levels of N-terminal fragment of the brain natriuretic peptide prohormone (NT-pro-BNP) are associated with myocardial ischemia in non-diabetic patients with stable angina pectoris. A total of 281 patients with diabetes mellitus type 2 and stable angina pectoris underwent myocardial perfusion scintigraphy (MPS). Myocardial ischemia on MPS was present in 140 (50%) patients. These ischemic patients had significantly higher NT-pro-BNP levels compared with patients without ischemia: 183 pg/ml (64-324 pg/ml) vs. 88 pg/ml (34-207 pg/ml), respectively (ppro-BNP ≥180 pg/ml was an independent predictor of the presence of myocardial ischemia (OR 2.36, 95%CI 1.40-3.97, p=0.001). Possible confounding factors such as age and creatinine clearance were of no influence on the predictive value in this specific patient population. These findings strengthen the idea that NT-pro-BNP may be of value in the early detection of diabetic patients with hemodynamic significant coronary artery disease. Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.

EGSNRC distributed systems on commercial network

International Nuclear Information System (INIS)

McCormack, J.M.

2001-01-01

Full text: EGSnrc is a Monte Carlo based simulation program for determining radiation dose distribution within a body. Computational times are large as each individual photon path must be calculated and every energy absorption event stored. This means that EGSnrc lends itself to distributed processing, as each photon is independent of the next, and code is included within the package to enable this. EGSnrc is currently only supported on Unix based computer systems, whilst the department has ∼45 Pentium II and III class workstations all operating under Windows NT within a Novell network. This investigation demonstrates the capability of a windows based system to perform distributed computation of EGSnrc. All Unix scripts were modified to work as one single Windows NT batch file. The source code was then compiled using the gcc C compiler (a Windows NT version of the Unix compiler) without modification of the underlying source code. A small Visual Basic program was used as a trigger to start the simulation as a Windows NT service, with Novell Z.E.N. Works to distribute the trigger code to each system. When a trigger was received, the computer began a simulation as a low priority task in such a way that the user did not see anything on the screen, and so the simulation did not slow down the general running of the computer. The results were then transferred to the network, and collated on a central computer. As an unattended system, a calculation can start within 15 minutes of any desired time, calculate the desired results, and return the results for collation. This demonstrated effectively a distributed Windows NT TM EGSnrc system. Simulations must be chosen carefully to ensure that each photon can be considered independent, as photon histories do not get distributed. Each system that was used for EGSnrc was required to be capable of running the full EGSnrc simulation on its own EGSnrc stored the entire result array locally, so a large, high-resolution body required

Serum levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in depressed patients with schizophrenia.

Science.gov (United States)

Wysokiński, Adam

2016-01-01

Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are neurotrophins-proteins that induce the survival, development, and function of neurons. Their role in the development of schizophrenia and mood disorders is widely studied. This study was aimed to determine whether depression affects levels of BDNF and NT-3 in patients with schizophrenia. Data for 53 Caucasian adult hospitalized patients with chronic paranoid schizophrenia was compared with 27 healthy subjects. Clinical symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS) and positive, negative and general sub-scores, the Calgary Depression Scale for Schizophrenia (CDSS), the Hamilton Depression Rating Scale (HDRS), and the Clinical Global Impressions scale (CGI). Patients were defined as depressed (SHZ-DEP) with scores CDSS > 6 and HDRS > 7, otherwise they were included into the non-depressed group (SHZ-nonDEP). In total, 17 patients (32.1%) with schizophrenia met criteria for depression. SHZ-DEP patients had higher scores in HDRS, CDSS, PANSS total, PANSS negative, PANSS general and CGI (p BDNF or NT-3 levels between patients with schizophrenia and controls. BDNF levels were lower in SHZ-DEP compared to SHZ-nonDEP: 18.82 ± 5.95 versus 22.10 ± 5.31 ng/mL, p = 0.045. NT-3 levels were higher in SHZ-DEP compared to SHZ-nonDEP: 133.31 ± 222.19 versus 56.04 ± 201.28 pg/mL, p = 0.033. There were no differences in neurotrophin levels between patients with schizophrenia and controls. We found lower BDNF and higher NT-3 serum levels in depressed patients with schizophrenia.

Description of the manufacture of a Geiger-Muller counter with window

International Nuclear Information System (INIS)

Granados, C. E.

1959-01-01

Total details about the manufacture elements in counter fabrication and the way of obtention are described as well as total indications useful in the installation process and filling of the counter. The appropriate materials and precautions that might be adopted in order to obtain counters with uniform operation and good characteristics, are described. Counters are of brass, with thin mica or aluminium windows and operate at 1100 V approximately with a slope lower than 5 % 1100 V. (Author)

Impact Analysis of Window-Wall Ratio on Heating and Cooling Energy Consumption of Residential Buildings in Hot Summer and Cold Winter Zone in China

Directory of Open Access Journals (Sweden)

Qiaoxia Yang

2015-01-01

Full Text Available In order to assess the optimal window-wall ratio and the proper glazing type in different air conditioning system operation modes of residential buildings for each orientation in three typical cities in hot summer and cold winter zone: Chongqing, Shanghai, and Wuhan simulation models were built and analyzed using Designer’s Simulation Toolkit (DeST. The study analyzed the variation of annual heating energy demand, annual cooling energy demand, and the annual total energy consumption in different conditions, including different orientations, patterns of utilization of air conditioning system, window-wall ratio, and types of windows. The results show that the total energy consumption increased when the window-wall ratio is also increased. It appears more obvious when the window orientation is east or west. Furthermore, in terms of energy efficiency, low-emissivity (Low-E glass performs better than hollow glass. From this study, it can be concluded that the influence and sensitivity of window-wall ratio on the total energy consumption are related to the operation mode of air conditioning system, the orientation of outside window, and the glazing types of window. The influence of the factors can be regarded as reference mode for the window-wall ratio when designing residential buildings.

Application of a Community eS@nté Platform in Maternal and Child ...

International Development Research Centre (IDRC) Digital Library (Canada)

Application of a Community eS@nté Platform in Maternal and Child Health in ... electronic patient files and telehealth can improve medical and healthcare data ... New website will help record vital life events to improve access to services for all.

Impact of three window configurations on daylight conditions

DEFF Research Database (Denmark)

Dubois, Marie-Claude; Sørensen, Karl Grau; Traberg-Borup, Steen

The report describes the results of a pilot study on daylight conditions in simple rooms of residential buildings. As a tool for the analyses the Radiance Lighting Simulating System was used to simulate one room with three different window configurations, a vertical window, a dormer window......, and a roof window. The simulations were performed for overcast sky conditions and under one sunny sky, for two different times of the day. The study shows that the window configuration affects the daylight conditions (distribution and intensity) significantly. The roof window results in a higher (average......) daylight factor on a horizontal plane, i.e. more than twice as high compared with the vertical window, and more than triple as high compared with the dormer window....

Communities’ Strategic Opportunities Through Broken Window Repair and Global Commons Improvements

Science.gov (United States)

2014-06-01

capabilities (e.g., sensors, information,  biotechnology , miniaturization on the molecular level, cyber‐operations, space, directed‐ energy, and other...www.theatlantic.com/ magazine /print/1982/03/broken-windows/304465/ (Kendall and Voorhies, 2014) – Kendall, Jake and Rodger Voorhies, The Mobile-Finance...breakthrough capabilities (e.g., sensors, information, biotechnology , miniaturization on the molecular level, cyber-operations, space, directed- energy

Emulating conventional operator interfaces on window-based workstations

International Nuclear Information System (INIS)

Carr, G.P.

1990-01-01

This paper explores an approach to support the LAMPF and PSR control systems on VAX/VMS workstations using DECwindows and VI Corporation Data Views as the operator interface. The PSR control system was recently turned over to MP division and the two control-system staffs were merged into one group. One of the goals of this new group is to develop a common workstation-based operator console and interface which can be used in a single control room controlling both the linac and proton storage ring. The new console operator interface will need a high-level graphics toolkit for its implementation. During the conversion to the new consoles it will also probably be necessary to write a package to emulate the current operator interfaces at the software level. This paper describes a project to evaluate the appropriateness of VI Corporation's Data Views graphics package for use in the LAMPF control-system environment by using it to write an emulation of the LAMPF touch-panel interface to a large LAMPF control-system application program. A secondary objective of this project was to explore any productivity increases that might be realized by using an object-oriented graphics package and graphics editor. (orig.)

NT-proBNP and troponin T levels differ after haemodialysis with a low versus high flux membrane

OpenAIRE

Laveborn, Emilie; Lindmark, Krister; Skagerlind, Malin; Stegmayr, Bernd

2015-01-01

BACKGROUND: Brain natriuretic peptide (BNP), N-terminal-proBNP (NT-proBNP), and high sensitive cardiac troponin T (TnT) are markers that are elevated in chronic kidney disease and correlate with increased risk of mortality. Data are conflicting on the effect of biomarker levels by hemodialysis (HD).Our aim was to clarify to what extent HD with low-flux (LF) versus high-flux (HF) membranes affects the plasma levels of BNP, NT-proBNP, and TnT. METHODS AND MATERIALS: 31 HD patients were included...

Window and door opening behavior, carbon dioxide concentration, temperature, and energy use during the heating season in classrooms with different ventilation retrofits—ASHRAE RP1624

DEFF Research Database (Denmark)

Heebøll, Anna; Wargocki, Pawel; Toftum, Jørn

2018-01-01

of Copenhagen, Denmark, were retrofitted either with a decentralized, balanced supply and exhaust mechanical ventilation unit with heat recovery; automatically operable windows with an exhaust fan; automatically operable windows with alternating counter-flow heat recovery through slots in the outside wall......; or a visual feedback display unit showing the current classroom carbon dioxide concentration, thus advising when the windows should be opened. For comparison, one classroom retained the original approach for achieving ventilation by manual opening of windows. One year after retrofitting the classrooms carbon...... dioxide concentrations, temperatures, energy use, and window and door opening behavior were recorded during a four week period in the heating season in January. The measured carbon dioxide concentrations were significantly lower in the classrooms with the mechanical ventilation system and the system...

Transparent solar cell window module

Energy Technology Data Exchange (ETDEWEB)

Chau, Joseph Lik Hang; Chen, Ruei-Tang; Hwang, Gan-Lin; Tsai, Ping-Yuan [Nanopowder and Thin Film Technology Center, ITRI South, Industrial Technology Research Institute, Tainan County 709 (China); Lin, Chien-Chu [I-Lai Acrylic Corporation, Tainan City (China)

2010-03-15

A transparent solar cell window module based on the integration of traditional silicon solar cells and organic-inorganic nanocomposite material was designed and fabricated. The transparent solar cell window module was composed of a nanocomposite light-guide plate and traditional silicon solar cells. The preparation of the nanocomposite light-guide plate is easy without modification of the traditional casting process, the nanoparticles sol can be added directly to the polymethyl methacrylate (PMMA) monomer syrup during the process. The solar energy collected by this window can be used to power up small household electrical appliances. (author)

Holography through optically active windows

Science.gov (United States)

Decker, A. J.

1979-01-01

By using two orthogonally polarized reference beams, holograms can be recorded through stressed windows and the reconstructed virtual image will show no stress pattern. As shown analytically, the stress-pattern-free hologram is recordable for any polarization state of the object illumination. Hence, the more efficient nondepolarizing diffuser can be used in performing holography through stressed windows if two reference beams are used. Results are presented for a pair of machined polysulfone windows intended for use in a holographic flow-visualization setup in a single-stage-compressor test rig.

Purged window apparatus utilizing heated purge gas

Science.gov (United States)

Ballard, Evan O.

1984-01-01

A purged window apparatus utilizing tangentially injected heated purge gases in the vicinity of electromagnetic radiation transmitting windows, and a tapered external mounting tube to accelerate these gases to provide a vortex flow on the window surface and a turbulent flow throughout the mounting tube. Use of this apparatus prevents backstreaming of gases under investigation which are flowing past the mouth of the mounting tube which would otherwise deposit on the windows. Lengthy spectroscopic investigations and analyses can thereby be performed without the necessity of interrupting the procedures in order to clean or replace contaminated windows.

Effect of different cover crops on C and N cycling in sorghum NT systems.

Science.gov (United States)

Frasier, Ileana; Quiroga, Alberto; Noellemeyer, Elke

2016-08-15

In many no-till (NT) systems, residue input is low and fallow periods excessive, for which reasons soil degradation occurs. Cover crops could improve organic matter, biological activity, and soil structure. In order to study changes in soil carbon, nitrogen and microbial biomass a field experiment (2010-2012) was set up with sorghum (Sorghum bicolor Moench.) monoculture and with cover crops. Treatments were control (NT with bare fallow), rye (Secale cereale L.) (R), rye with nitrogen fertilization (R+N), vetch (Vicia villosa Roth.) (V), and rye-vetch mixture (VR) cover crops. A completely randomized block design with 4 replicates was used. Soil was sampled once a year at 0.06 and 0.12m depth for total C, microbial biomass carbon (MBC) and-nitrogen (MBN) determinations. Shoot and root biomass of sorghum and cover crops, litter biomass, and their respective carbon and nitrogen contents were determined. Soil temperatures at 0.06 and 0.12m depth, volumetric water contents and nitrate concentrations were determined at sowing, and harvest of each crop, and during sorghum's vegetative phase. NT led to a small increase in MBC and MBN, despite low litter and root biomass residue. Cover crops increased litter, root biomass, total C, MBC, and MBN. Relationships between MBC, MBN, and root-C and -N adjusted to logistic models (R(2)=0.61 and 0.43 for C and N respectively). Litter cover improved soil moisture to 45-50% water filled pore space and soil temperatures not exceeding 25°C during the warmest month. Microbial biomass stabilized at 20.1gCm(-2) and 1.9gNm(-2) in the upper 0.06m. Soil litter disappearance was a good indicator of mineral N availability. These findings support the view that cover crops, specifically legumes in NT systems can increase soil ecosystem services related to water and carbon storage, habitat for biodiversity, and nutrient availability. Copyright © 2016 Elsevier B.V. All rights reserved.

Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults

Directory of Open Access Journals (Sweden)

Junichi Yatabe

2012-01-01

Full Text Available G protein-coupled receptor kinase 4 (GRK4 with activating polymorphisms desensitize the natriuric renal tubular D1 dopamine receptor, and these GRK4 polymorphisms are strongly associated with salt sensitivity and hypertension. Meanwhile, N-terminal pro-B-type natriuretic peptide (NT-proBNP may be useful in detecting slight volume expansion. However, relations between hypertension-related gene polymorphisms including GRK4 and cardiovascular indices such as NT-proBNP are not clear, especially in healthy subjects. Therefore, various hypertension-related polymorphisms and cardiovascular indices were analyzed in 97 normotensive, healthy Japanese adults. NT-proBNP levels were significantly higher in subjects with two or more GRK4 polymorphic alleles. Other hypertension-related gene polymorphisms, such as those of renin-angiotensin-aldosterone system genes, did not correlate with NT-proBNP. There was no significant association between any of the hypertension-related gene polymorphisms and central systolic blood pressure, cardioankle vascular index, augmentation index, plasma aldosterone concentration, or an oxidative stress marker, urinary 8-OHdG. Normotensive individuals with GRK4 polymorphisms show increased serum NT-proBNP concentration and may be at a greater risk of developing hypertension and cardiovascular disease.

NT-proBNP as Marker of Ventricular Dilatation and Pulmonary Regurgitation After Surgical Correction of Tetralogy of Fallot: A MRI Validation Study.

Science.gov (United States)

Paolino, Annalisa; Hussain, Tarique; Pavon, Antonio; Velasco, Maria Nieves; Uribe, Sergio; Ordoñez, Antonio; Valverde, Israel