Sample records for wilklow colette mutz
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Reading in Colette: Domination, Resistance, Autonomy
Directory of Open Access Journals (Sweden)
Laurel Cummins
1996-06-01
Full Text Available The act of reading on the part of Colette's characters reveals itself as a dynamic involving domination and resistance. A study of passages from two of her semi-autobiographical works, La Maison de Claudine and Sido , brings to light both a positively connoted model of reading, exemplified by the character 'Colette,' and a negatively connoted model, exemplified by the older sister Juliette. While Juliette approaches texts with no sense of self, and seeks instead to be defined by the texts she reads, 'Colette' remains in relation to texts and to the discourses they contain, and resists them. Gender complicates the process. Both father and mother intervene in 'Colette's' apprenticeship as reader. While the censorship that constitutes the father's intervention proves both debilitating and disempowering, the mother's modeling of reading as dialogue and resistance empowers 'Colette,' both as a reader and a female being.
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International Nuclear Information System (INIS)
Heenan, R.W.; King, S.M.; Osborn, R.; Stanley, H.B.
1989-12-01
This guide describes the computer program COLETTE. It has been purposely designed to reduce the small-angle data collected on the ISIS small-angle neutron camera LOQ in an interactive and user-friendly manner. This not only gives the LOQ user an opportunity to inspect data rapidly and comprehensively during the course of an experiment but also provides the instrument scientists with a flexible diagnostic tool with which they can monitor the performance of the instrument. After the experiment is completed, COLETTE may be used to provide the final I(Q) versus Q following subtraction of a sample background run and normalisation to a scattering standard. By limiting the range of azimuthal angles included in the analysis the program may take sections through an anisotropic scattering pattern from an ordered system. A completely two dimensional I(Q x ,Q y ) map may also be generated. (author)
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Directory of Open Access Journals (Sweden)
Claudia Fonseca
2014-06-01
Full Text Available O seminário "Les sentiers de l'ethnologie urbaine, avec Colette Pétonnet" ("Pistas da etnologia urbana, com Colette Petonnet", realizado entre 3 e 4 de outubro de 2013, no Muséum National d'Histoire Naturelle - Paris, reuniu diversos pesquisadores para uma homenagem póstuma a esta precursora da etnologia em meio urbano, fundadora, com Jacques Gutwirth, do Laboratoire d'Anthropologie Urbaine do Centre National de Recherche Scientifique (LAU/CNRS. Este artigo é uma tradução do paper enviado por Claudia Fonseca, ex-orientanda da homenageada, apresentado, na ocasião, em forma de um vídeo, produzido em conjunto com Claudia Turra Magni e Mauro Bruschi, sob o título Colette Pétonnet au Brésil: les effets pédagogiques d'un exercice ethnographique. Aqui, as autoras evocam as marcas e repercussões dos ensinamentos da mestra, a partir de sua estada no Brasil, na última década do século passado.
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Energy Technology Data Exchange (ETDEWEB)
Kosten, Ilona J.; Spiekstra, Sander W. [Department of Dermatology, VU University Medical Center, Amsterdam (Netherlands); Gruijl, Tanja D. de [Department of Dermatology Medical Oncology, VU University Medical Center, Amsterdam (Netherlands); Gibbs, Susan, E-mail: s.gibbs@acta.nl [Department of Dermatology, VU University Medical Center, Amsterdam (Netherlands); Department of Oral Cell Biology, Academic Center for Dentistry (ACTA), Amsterdam (Netherlands)
2015-08-15
After allergen or irritant exposure, Langerhans cells (LC) undergo phenotypic changes and exit the epidermis. In this study we describe the unique ability of MUTZ-3 derived Langerhans cells (MUTZ-LC) to display similar phenotypic plasticity as their primary counterparts when incorporated into a physiologically relevant full-thickness skin equivalent model (SE-LC). We describe differences and similarities in the mechanisms regulating LC migration and plasticity upon allergen or irritant exposure. The skin equivalent consisted of a reconstructed epidermis containing primary differentiated keratinocytes and CD1a{sup +} MUTZ-LC on a primary fibroblast-populated dermis. Skin equivalents were exposed to a panel of allergens and irritants. Topical exposure to sub-toxic concentrations of allergens (nickel sulfate, resorcinol, cinnamaldehyde) and irritants (Triton X-100, SDS, Tween 80) resulted in LC migration out of the epidermis and into the dermis. Neutralizing antibody to CXCL12 blocked allergen-induced migration, whereas anti-CCL5 blocked irritant-induced migration. In contrast to allergen exposure, irritant exposure resulted in cells within the dermis becoming CD1a{sup −}/CD14{sup +}/CD68{sup +} which is characteristic of a phenotypic switch of MUTZ-LC to a macrophage-like cell in the dermis. This phenotypic switch was blocked with anti-IL-10. Mechanisms previously identified as being involved in LC activation and migration in native human skin could thus be reproduced in the in vitro constructed skin equivalent model containing functional LC. This model therefore provides a unique and relevant research tool to study human LC biology in situ under controlled in vitro conditions, and will provide a powerful tool for hazard identification, testing novel therapeutics and identifying new drug targets. - Highlights: • MUTZ-3 derived Langerhans cells integrated into skin equivalents are fully functional. • Anti-CXCL12 blocks allergen-induced MUTZ-LC migration.
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International Nuclear Information System (INIS)
Azam, Philippe; Peiffer, Jean-Luc; Chamousset, Delphine; Tissier, Marie-Helene; Bonnet, Pierre-Antoine; Vian, Laurence; Fabre, Isabelle; Ourlin, Jean-Claude
2006-01-01
Langerhans cells (LC) are key mediators of contact allergenicity in the skin. However, no in vitro methods exist which are based on the activation process of LC to predict the sensitization potential of chemicals. In this study, we have evaluated the performances of MUTZ-3, a cytokine-dependent human monocytic cell line, in its response to sensitizers. First, we compared undifferentiated MUTZ-3 cells with several standard human cells such as THP-1, KG-1, HL-60, K-562, and U-937 in their response to the strong sensitizer DNCB and the irritant SDS by monitoring the expression levels of HLA-DR, CD54, and CD86 by flow cytometry. Only MUTZ-3 and THP-1 cells show a strong and specific response to sensitizer, while other cell lines showed very variable responses. Then, we tested MUTZ-3 cells against a wider panel of sensitizers and irritants on a broader spectrum of cell surface markers (HLA-DR, CD40, CD54, CD80, CD86, B7-H1, B7-H2, B7-DC). Of these markers, CD86 proved to be the most reliable since it detected all sensitizers, including benzocaine, a classical false negative in local lymph node assay (LLNA) but not irritants. We confirmed the MUTZ-3 response to DNCB by real-time PCR analysis. Taken together, our data suggest that undifferentiated MUTZ-3 cells may represent a valuable in vitro model for the screening of potential sensitizers
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Kosten, I.J.; Spiekstra, S.W.; de Gruijl, T.D.; Gibbs, S.
2015-01-01
After allergen or irritant exposure, Langerhans cells (LC) undergo phenotypic changes and exit the epidermis. In this study we describe the unique ability of MUTZ-3 derived Langerhans cells (MUTZ-LC) to display similar phenotypic plasticity as their primary counterparts when incorporated into a
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Pregnancias. Sobre cuatro lavis de Colette Deblé
Directory of Open Access Journals (Sweden)
Jacques Derrida
2013-07-01
Full Text Available ¿Cómo citar la representación del cuerpo femenino en la Historia del Arte occidental dejándose impregnar por los patrones y modelos pictóricos masculinos pero imprimiendo, a su vez, otras huellas, las de otro cuerpo? Esta pregunta atraviesa el texto del filósofo Jacques Derrida sobre las aguadas (lavis de la pintora francesa Colette Deblé, dando lugar a una reflexión sobre el engendramiento, el parto y la cita pictórica. En el trabajo de Colette Deblé, el legado de la Historia del Arte y su mitología engendrarán una serie infinita de aguadas donde el agua no pretende “lavar” la tradición (deshacerse de ella, acabar con ella sino inundarla, mojarla, empaparla con nuevas aguas para, escurriéndola, hacerla resonar nuevamente.
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Laura Mariani, Sarah Bernhardt, Colette e l'arte del travestimento ...
African Journals Online (AJOL)
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Laura Mariani, Sarah Bernhardt, Colette e l'arte del travestimento,. Bologna, Il Mulino, 1996. Anche questo secondo libro che Laura Mariani dedica alla storia delle attrici si svolge al confine tra storia del teatro e storia delle donne: un intreccio fertile di suggestioni e spunti teorici. Tema dell'indagine, condotta soprattutto ...
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Space and Salvation in Colette's Chéri and La Fin de Chéri
Directory of Open Access Journals (Sweden)
Ann Leone Philbrick
1984-01-01
Full Text Available Colette's critics often seem to dismiss all but her autobiographical creatures as whimsical and inarticulate. Her characters are frequently less eloquent than the spaces they create and inhabit; this observation offers an approach to Chéri and La Fin de Chéri that invites us to read them as two of Colette's most ambitious and authentic works. Here are stories of compromises with the containers of one's life and identity: streets, salons, boudoirs, and, ultimately, the body. Indeed, the self and its containers function symbiotically. Chéri makes no effort to direct this relationship, and kills himself when the world finally seems inscrutable and formless; his older mistress, Léa, responds joyfully—or with melancholic respect—to the surfaces and limits of her world. We are left with a harsher insight into Colette's vision than we are accustomed to. She suggests that survival lies not in the endless definition of one's place in the world, but in its recognition and a loving, even fearing, homage.
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Directory of Open Access Journals (Sweden)
Paola Palma
2012-07-01
Full Text Available Nel 1932 Colette realizza i sottotitoli francesi del film tedesco Mädchen in Uniform (T. fr. : Jeunes filles en uniforme, 1931, diretto da Leontine Sagan e tratto da un testo teatrale di Christa Winsloe. La scrittrice viene interpellata dal distributore francese della pellicola, ma accetta il lavoro solo dopo avere visto il film, che analizza attentamente e giudica estremamente riuscito. Si ha la conferma dell’interesse della scrittrice per il mondo delle immagini in movimento, oltre allo stimolante intrecciarsi di alcuni elementi del plot, dei personaggi e dell’ambientazione del film con quelli dei volumi colettiani delle Claudine, con i quali Mädchen in Uniform condividerà anche una significativa e duratura diffusione e popolarità.Il contatto tra la letteratura e il cinema non si esaurisce quindi nella traduzione di un testo per il cinema da parte di una scrittrice, ma prosegue in più direzioni. Vi è anche l’aspetto pubblicitario (e meramente economico, di cui beneficiano e sono consapevoli entrambe le parti: lo stesso “personaggio” Colette si sovrappone all’immagine che si intende dare di Jeunes filles en uniforme. Il film, inoltre, è uno dei titoli fondamentali negli studi sulla storia del cinema gay e lesbico. In questo ambito, questa collaborazione è significativa in termini di ricezione di una pellicola a sfondo lesbico perché l’accostamento del nome di Colette ha senz’altro contribuito all’accoglienza del film in Francia.En 1932, Colette rédige les sous-titres français du film allemand Mädchen in Uniform (Jeunes filles en uniforme, 1931, adapté par l’Autrichienne Léontine Sagan d’une pièce de Christa Winsloe. L'écrivain est sollicitée par le distributeur français, mais elle n'accepte le travail qu'après avoir vu le film, qu'elle analyse attentivement et juge très réussi. On peut y voir la confirmation de son intérêt pour l'univers des images animées. Mais en outre, on relève de nombreux et
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Entrevue guidée avec Colette Dion Hubert
Directory of Open Access Journals (Sweden)
Raymond Baril
2006-05-01
Full Text Available Collette Dion-Hubert est une pionnière dans le domaine de l’ergothérapie et de l’utilisation de l’ergonomie de l’activité de travail en réadaptation au Québec. Selon elle, alors que l’ergothérapie procède d’une approche individuelle des problématiques, l’ergonomie apporte une vision plus globale qui est essentielle à la transformation des situations de travail pathogènes. Elle a comme espoir que les pénuries de main-d’œuvre qui se dessinent dans certains métiers créeront de nouvelles possibilités d’insertion sécuritaire des « personnes différentes » au travail.Collette Dion-Hubert is a pioneer in the field of occupational therapy and the use of ergonomics of the work activity in rehabilitation in Québec. According to her, while occupational therapy stems from an individual approach to the problems, ergonomics provides a more comprehensive view that is vital in the transformation of pathogenic work situations. Her hope is that the labour shortages that are occurring in some professions will create new possibilities for the safe integration of « different people » into the work.Colette Dion-Hubert es una pionera en el campo de la ergoterapia y de la utilización de la ergonomía de la actividad en readaptación, en Quebec. Según ella, mientras la ergoterapia enfoca los problemas de una manera individual, la ergonomía aporta una visión más global, esencial cuando se trata de transformar situaciones de trabajo patógenas. Colette Dion-Hubert tiene la esperanza que la penuria de mano de obra que se prevee en varios oficios, creará nuevas posibilidades para la inserción de « personas diferentes » a trabajos que respeten su seguridad.
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International Nuclear Information System (INIS)
Sebastian, Katrin; Ott, Hagen; Zwadlo-Klarwasser, Gabriele; Skazik-Voogt, Claudia; Marquardt, Yvonne; Czaja, Katharina; Merk, Hans F.; Baron, Jens Malte
2012-01-01
Since the 7th amendment to the EU cosmetics directive foresees a complete ban on animal testing, alternative in vitro methods have been established to evaluate the sensitizing potential of small molecular weight compounds. To find out whether these novel in vitro assays are also capable to predict the sensitizing potential of small molecular weight drugs, model compounds such as beta-lactams and sulfonamides – which are the most frequent cause of adverse drug reactions – were co-incubated with THP-1, MUTZ-LC, or primary monocyte‐derived dendritic cells for 48 h and subsequent expression of selected marker genes (IL-8, IL-1β, CES1, NQO1, GCLM, PIR and TRIM16) was studied by real time PCR. Benzylpenicillin and phenoxymethylpenicillin were recognized as sensitizing compounds because they are capable to induce the mRNA expression of these genes in moDCs and, except for IL-8, in THP-1 cells but not in MUTZ-LC. Ampicillin stimulated the expression of some marker genes in moDCs and THP-1 cells. SMX did not affect the expression of these genes in THP-1, however, in moDCs, at least PIR was enhanced and there was an increase of the release of IL-8. These data reveal that novel in vitro DC based assays might play a role in the evaluation of the allergenic potential of novel drug compounds, but these systems seem to lack the ability to detect the sensitizing potential of prohaptens that require metabolic activation prior to sensitization and moDCs seem to be superior with regard to the sensitivity compared with THP-1 and MUTZ-3 cell lines. -- Highlights: ► We tested the sensitizing potential of small molecular weight drugs in vitro. ► In vitro assays were performed with moDCs and THP-1 cells. ► Beta-lactam antibiotics can be recognized as sensitizing compounds. ► They affect the expression of metabolic enzymes, cytokines and transcription factors. ► Sulfamethoxazole has no measurable effect on THP-1 cells and moDCs.
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Energy Technology Data Exchange (ETDEWEB)
Sebastian, Katrin, E-mail: ksebastian@ukaachen.de [Department of Dermatology and Allergology, RWTH Aachen University Hospital, D-52074 Aachen (Germany); Ott, Hagen [Department of Dermatology and Allergology, RWTH Aachen University Hospital, D-52074 Aachen (Germany); Zwadlo-Klarwasser, Gabriele [IZKF (BIOMAT), RWTH Aachen University Hospital, D-52074 Aachen (Germany); Skazik-Voogt, Claudia; Marquardt, Yvonne; Czaja, Katharina; Merk, Hans F.; Baron, Jens Malte [Department of Dermatology and Allergology, RWTH Aachen University Hospital, D-52074 Aachen (Germany)
2012-08-01
Since the 7th amendment to the EU cosmetics directive foresees a complete ban on animal testing, alternative in vitro methods have been established to evaluate the sensitizing potential of small molecular weight compounds. To find out whether these novel in vitro assays are also capable to predict the sensitizing potential of small molecular weight drugs, model compounds such as beta-lactams and sulfonamides – which are the most frequent cause of adverse drug reactions – were co-incubated with THP-1, MUTZ-LC, or primary monocyte‐derived dendritic cells for 48 h and subsequent expression of selected marker genes (IL-8, IL-1β, CES1, NQO1, GCLM, PIR and TRIM16) was studied by real time PCR. Benzylpenicillin and phenoxymethylpenicillin were recognized as sensitizing compounds because they are capable to induce the mRNA expression of these genes in moDCs and, except for IL-8, in THP-1 cells but not in MUTZ-LC. Ampicillin stimulated the expression of some marker genes in moDCs and THP-1 cells. SMX did not affect the expression of these genes in THP-1, however, in moDCs, at least PIR was enhanced and there was an increase of the release of IL-8. These data reveal that novel in vitro DC based assays might play a role in the evaluation of the allergenic potential of novel drug compounds, but these systems seem to lack the ability to detect the sensitizing potential of prohaptens that require metabolic activation prior to sensitization and moDCs seem to be superior with regard to the sensitivity compared with THP-1 and MUTZ-3 cell lines. -- Highlights: ► We tested the sensitizing potential of small molecular weight drugs in vitro. ► In vitro assays were performed with moDCs and THP-1 cells. ► Beta-lactam antibiotics can be recognized as sensitizing compounds. ► They affect the expression of metabolic enzymes, cytokines and transcription factors. ► Sulfamethoxazole has no measurable effect on THP-1 cells and moDCs.
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International Nuclear Information System (INIS)
Python, Francois; Goebel, Carsten; Aeby, Pierre
2009-01-01
The number of studies involved in the development of in vitro skin sensitization tests has increased since the adoption of the EU 7th amendment to the cosmetics directive proposing to ban animal testing for cosmetic ingredients by 2013. Several studies have recently demonstrated that sensitizers induce a relevant up-regulation of activation markers such as CD86, CD54, IL-8 or IL-1β in human myeloid cell lines (e.g., U937, MUTZ-3, THP-1) or in human peripheral blood monocyte-derived dendritic cells (PBMDCs). The present study aimed at the identification of new dendritic cell activation markers in order to further improve the in vitro evaluation of the sensitizing potential of chemicals. We have compared the gene expression profiles of PBMDCs and the human cell line MUTZ-3 after a 24-h exposure to the moderate sensitizer cinnamaldehyde. A list of 80 genes modulated in both cell types was obtained and a set of candidate marker genes was selected for further analysis. Cells were exposed to selected sensitizers and non-sensitizers for 24 h and gene expression was analyzed by quantitative real-time reverse transcriptase-polymerase chain reaction. Results indicated that PIR, TRIM16 and two Nrf2-regulated genes, CES1 and NQO1, are modulated by most sensitizers. Up-regulation of these genes could also be observed in our recently published DC-activation test with U937 cells. Due to their role in DC activation, these new genes may help to further refine the in vitro approaches for the screening of the sensitizing properties of a chemical.
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Hitzler, Manuel; Bergert, Antje; Luch, Andreas; Peiser, Matthias
2013-09-01
Dendritic cells (DCs) exhibit the unique capacity to induce T cell differentiation and proliferation, two processes that are crucially involved in allergic reactions. By combining the exclusive potential of DCs as the only professional antigen-presenting cells of the human body with the well known handling advantages of cell lines, cell-based alternative methods aimed at detecting chemical sensitization in vitro commonly apply DC-like cells derived from myeloid cell lines. Here, we present the new biomarkers programmed death-ligand 1 (PD-L1), DC immunoreceptor (DCIR), IL-16, and neutrophil-activating protein-2 (NAP-2), all of which have been detectable in primary human DCs upon exposure to chemical contact allergens. To evaluate the applicability of DC-like cells in the prediction of a chemical's sensitization potential, the expression of cell surface PD-L1 and DCIR was analyzed. In contrast to primary DCs, only minor subpopulations of MUTZ-3 and THP-1 cells presented PD-L1 or DCIR at their surface. After exposure to increasing concentrations of nickel and cinnamic aldehyde, the expression level of PD-L1 and DCIR revealed much stronger affected on monocyte-derived DCs (MoDCs) or Langerhans cells (MoLCs) when compared to THP-1 and MUTZ-3 cells. Applying protein profiler arrays we further identified the soluble factors NAP-2, IL-16, IL-8 and MIP-1α as sensitive biomarkers showing the capacity to discriminate sensitizing from non-sensitizing chemicals or irritants. An allergen-specific release of IL-8 and MIP-1α could be detected in the supernatants of MoDCs and MoLCs and also in MUTZ-3 and THP-1 cells, though at much lower levels. On the protein and transcriptional level, NAP-2 and IL-16 indicated sensitizers most sensitively and specifically in MoDCs. Altogether, we have proven the reciprocal regulated surface molecules PD-L1 and DCIR and the soluble factors MIP-1α, NAP-2 and IL-16 as reliable biomarkers for chemical sensitization. We further show that primary
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Directory of Open Access Journals (Sweden)
Marie-Aline Barrachina
2009-08-01
Full Text Available Colette Rabaté propose avec ce livre une incursion dans le petit monde des femmes des classes moyennes espagnoles entre le début de la régence de Marie Christine et la fin du règne d’Isabelle II. Le titre et le sous titre de l’ouvrage laissent entendre d’emblée qu’il se situe dans la perspective d’une étude des représentations, représentations qui, dans le cas de l’Espagne du milieu du XIXe siècle, sont imprégnées d’une culture catholique largement hégémonique. L’allusion à Eve et à Marie es...
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Gibbs, Susan; Spiekstra, Sander; Corsini, Emanuela; McLeod, Julie; Reinders, Judith
2013-04-01
This manuscript describes methodology and a prediction model for the MUTZ-LC migration assay. The assay represents the physiological change in Langerhans cell (LC) behavior after exposure to a sensitizing chemical, resulting in LC migration from the epidermis to the dermis. MUTZ-LC are derived from the commercially available MUTZ-3 cell line. Upon exposure to a sensitizer MUTZ-LC migrate preferentially towards CXCL12 whereas upon exposure to a non-sensitizer MUTZ-LC migrate towards CCL5. A CXCL12/CCL5 ratio >1.10 in 2/3 independent experiments is indicative of a sensitizer, whereas a CXCL12/CCL5 ratio ≤1.10 is indicative of a non-sensitizer. At non cytotoxic chemical concentrations 9 sensitizers (2,4-dinitrochlorobenzene, paraphenylendiamine, cinnamaldehyde, isoeugenol, nickel-sulfate, tetramethylthiuram disulfide, eugenol, cinnamic-alcohol, ammonium-hexachloroplatinate) were distinguished from 4 non sensitizers (sodium lauryl sulfate, salicylic acid, phenol, octanoic acid). Critical points in assay performance are (i) MUTZ-3 passage number after thawing (p6-p40); (ii) cell viability (>80%); (iii) standard curve to optimize correlation of fluorescence with cell number; and (iv) optimization of the concentration of rhCXCL12 and rhCCL5 in transwell. The protocol has been tested in three European laboratories and results suggest that it may provide working conditions for performing the DC migration assay which is aimed at distinguishing sensitizers from non sensitizers. Copyright © 2012 Elsevier Ltd. All rights reserved.
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Directory of Open Access Journals (Sweden)
Jian Ning
2011-01-01
Full Text Available Most anti-cancer immunotherapeutic strategies involving dendritic cells (DC as vaccines rely upon the adoptive transfer of DC loaded with exogenous tumour-peptides. This study utilized human acute myeloid leukemia (AML cells as progenitors from which functional dendritic-like antigen presenting cells (DLC were generated, that constitutively express tumour antigens for recognition by CD8+ T cells. DLC were generated from AML cell lines KG-1 and MUTZ-3 using rapid culture techniques and appropriate cytokines. DLC were evaluated for their cell-surface phenotype, antigen uptake and ability to stimulate allogeneic responder cell proliferation, and production of IFN-γ; compared with DC derived from normal human PBMC donors. KG-1 and MUTZ-3 DLC increased expression of CD80, CD83, CD86, and HLA-DR, and MUTZ-3 DLC downregulated CD14 and expressed CD1a. Importantly, both KG-1 and MUTZ-3-derived DLC promoted proliferation of allogeneic responder cells more efficiently than unmodified cells; neither cells incorporated FITC-labeled dextran, but both stimulated IFN-γ production from responding allogeneic CD8+ T cells. Control DC produced from PBMC using the FastDC culture also expressed high levels of critical cell surface ligands and demonstrated good APC function. This paper indicates that functional DLC can be cultured from the AML cell lines KG-1 and MUTZ-3, and FastDC culture generates functional KG-1 DLC.
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Kang, Hui-Yuan; Wang, Xin-Rong; Gao, Li; Wang, Wei; Li, Mian-Yang; Wang, Li-Li; Wang, Cheng-Bin; Yu, Li
2015-04-01
To evaluate significance of ID4 gene mehtylation in demethylating myelodysplastic syndrome(MDS) cell Line MUTZ1 and 2 patients with MDS. The methylation-specific PCR (MS-PCR) and reverse transcription-PCR (RT-PCR) were applied to identify the methylation status and gene expression of ID4 gene in MDS cell line MUTZ1, a patient with aplastic anemia(AA) and a donor with normal bone marrow (NBM). RT-PCR was applied to detect the ID4 gene expression status in MUTZ1 cell line treated with decitabine at 3 different concentrations. Then bisulfite sequencing PCR (BSP) was applied to detect ID4 gene methylation status in 2 MDS parients treated with decitabine. The MDS cell line MUTZ-1 displayed a complete methylation of ID4 gene promoter with little mRNA expression. Inversely, bone marrow of an AA patient and NBM showed complete unmethylation of this gene with intensity mRNA expression. With the increase of decitabine concentration, ID4 gene mRNA expression was more and more increased. After decitabine treatment, ID4 gene methylation-positive frequencies of both the 2 MDS patients were much more decreased than that of the first treatment. So, ID4 gene mRNA expression inhibited by promoter hypemethylation could be recovered by using demethylation medicine. ID4 as a new potential anti-oncogene suggests that its methylation may become a marker for selection and assessment of therapeutic schedules in patients with MDS.
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2012-05-10
... September 30, 2010 (``BDA Letter I''); Colette J. Irwin-Knott, CIPFA, President, National Association of... December 1, 2011 (``BDA Letter II''); Susan Gaffney, Director, Federal Liaison Center, Government Finance... America, dated January 30, 2012 (``BDA Letter III''); Colette J. Irwin-Knott, CIPFA, President, National...
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75 FR 1621 - Change in Bank Control Notices; Acquisition of Shares of Bank or Bank Holding Companies
2010-01-12
..., 2010. A. Federal Reserve Bank of Chicago (Colette A. Fried, Assistant Vice President) 230 South LaSalle Street, Chicago, Illinois 60690-1414: 1. John E. Helgerson, Ottumwa, Iowa; to acquire additional shares...
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1998-01-01
Yohji Yamamoto moeshowl astusid lavale Vivienne Westwood, Ines de la Fressage jt. Modell Eva Herzigovast. Austraalia moenädalal esinenud edukaid austraalia moekunstnikke : Colette Dinnigan (nimekaim), Zimmerman, Charlie Brown, Zambesi, Nicola Finetti, Nicholas Blanchet.
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2011-11-21
...''); Colette J. Irwin-Knott, CIPFA, President, National Association of Independent Public Finance Advisors...''); and Susan Gaffney, Director, Federal Liaison Center, Government Finance Officers Association, dated... principles of trade, to foster cooperation and coordination with persons engaged in regulating, clearing...
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Universal Partial Words over Non-Binary Alphabets
Goeckner, Bennet; Groothuis, Corbin; Hettle, Cyrus; Kell, Brian; Kirkpatrick, Pamela; Kirsch, Rachel; Solava, Ryan
2016-01-01
Chen, Kitaev, M\\"{u}tze, and Sun recently introduced the notion of universal partial words, a generalization of universal words and de Bruijn sequences. Universal partial words allow for a wild-card character $\\diamond$, which is a placeholder for any letter in the alphabet. We settle and strengthen conjectures posed in the same paper where this notion was introduced. For non-binary alphabets, we show that universal partial words have periodic $\\diamond$ structure and are cyclic, and we give ...
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2011-08-29
... Proposed Information Collection to OMB Section 8 Random Digit Dialing Fair Marketing Rent Surveys AGENCY: Office of the Chief Information Officer, HUD. ACTION: Notice. SUMMARY: The proposed information.... FOR FURTHER INFORMATION CONTACT: Colette Pollard., Reports Management Officer, QDAM, Department of...
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2013-04-22
... Information Collection: Comment Request: HUD- Administered Small Cities Program Performance Assessment Report... program provides HUD with financial and physical development status of each activity funded. These reports[email protected] fax: 202-395-5806. FOR FURTHER INFORMATION CONTACT: Colette Pollard, Reports...
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2010-11-03
... November 16, 2010. A. Federal Reserve Bank of Chicago (Colette A. Fried, Assistant Vice President) 230 South LaSalle Street, Chicago, Illinois 60690-1414: 1. Robert John Dentel, Victor, Iowa, and Mary P...; 8:45 am] BILLING CODE 6210-01-P ...
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2012-04-03
... April 27, 2012. A. Federal Reserve Bank of Chicago (Colette A. Fried, Assistant Vice President) 230..., Grafton, Wisconsin, John Lukas, and Mark Lukas, both of Manitowoc, Wisconsin, and the Foy minor children...-7958 Filed 4-2-12; 8:45 am] BILLING CODE 6210-01-P ...
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2012-04-17
... May 2, 2012. A. Federal Reserve Bank of Chicago (Colette A. Fried, Assistant Vice President) 230 South...; Anne R. Sparks, John W. Sparks, and Zachary Whitten, all of Albuquerque, New Mexico; Benjamin I... Filed 4-16-12; 8:45 am] BILLING CODE 6210-01-P ...
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2013-01-24
... February 11, 2013. A. Federal Reserve Bank of Chicago (Colette A. Fried, Assistant Vice President) 230..., as independent trustee of Trust, Kurt Bosshard, Kapaa, Hawaii, John Bosshard III, McCarthy, Alaska..., California, Elizabeth Bosshard-Blakely, South Pasadena, California, Alexandra Bosshard, Sandy, Utah, and John...
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2013-10-23
... Federal Relay Service at (800) 877-8339. FOR FURTHER INFORMATION CONTACT: Colette Pollard, Reports... the toll-free Federal Relay Service at (800) 877-8339. Copies of available documents submitted to OMB... information technology, e.g., permitting electronic submission of responses. This Notice also lists the...
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2013-10-23
... Relay Service at (800) 877-8339. FOR FURTHER INFORMATION CONTACT: Colette Pollard, Reports Management...-free Federal Relay Service at (800) 877-8339. Copies of available documents submitted to OMB may be... techniques or other forms of information technology, e.g., permitting electronic submission of responses...
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2011-09-30
... Financial Markets Association, dated August 29, 2011; and letter from Joy A. Howard, Principal, WM Financial..., Commission, from Colette J. Irwin-Knott, CIPFA, President, National Association of Independent Public Finance... Commission, by the Division of Trading and Markets, pursuant to delegated authority.\\6\\ Elizabeth M. Murphy...
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2013-08-26
... INFORMATION CONTACT: Colette Pollard, Reports Management Officer, QDAM, Department of Housing and Urban... telephone 202-402-3400. Persons with hearing or speech impairments may access this number through TTY by... the mortgagor, at the time of loan application, a written explanation of the features of an adjustable...
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2013-06-03
... June 18, 2013. A. Federal Reserve Bank of Chicago (Colette A. Fried, Assistant Vice President) 230.... Paul M. Freeman, as custodian for Ann E. Freeman, both of Texhoma, Oklahoma, the John L. Freeman 2012...-13005 Filed 5-31-13; 8:45 am] BILLING CODE 6210-01-P ...
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Cognitive Algorithms for Signal Processing
2011-03-18
Analysis of Millennial Spiritual Issues,” Zygon, Journal of Science and Religion , 43(4), 797-821, 2008. [46] R. Linnehan, C. Mutz, L.I. Perlovsky, B...dimensions of X and Y : (a) true ‘smile’ and ‘frown’ patterns are shown without clutter; (b) actual image available for recognition (signal is below...clutter in 2 dimensions of X(n) = (X, Y ), is given by l(X(n)|m = clutter) = 1/ (X • Y ), X = (Xmax-Xmin), Y = (Ymax-Ymin); (6) 13 Minimal
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2013-07-16
... July 30, 2013. A. Federal Reserve Bank of Chicago (Colette A. Fried, Assistant Vice President) 230...Bois Schmitze and John DuBois, both of Sauk Centre, Minnesota, as members of the Margaret DuBois Family.... 2013-16923 Filed 7-15-13; 8:45 am] BILLING CODE 6210-01-P ...
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2010-11-12
... November 26, 2010. A. Federal Reserve Bank of Chicago (Colette A. Fried, Assistant Vice President) 230 South LaSalle Street, Chicago, Illinois 60690-1414: 1. Robert John Dentel, Victor, Iowa, and Mary P. Howell, Ames, Iowa, individually; and the Robert John Dentel Family (Robert J. Dentel, Patricia A. Dentel...
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2012-11-19
..., South Carolina. B. Federal Reserve Bank of Chicago (Colette A. Fried, Assistant Vice President) 230.... Woods, Bluffton, South Carolina, individually and as part of a group acting in concert with Edgar Woods.... Woods, Milton Woods Jr. and Susan H Woods, both of Ridgeland, South Carolina, and J. Eric Woods...
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2013-08-28
... Bank of Delmarva, Seaford, Delaware. B. Federal Reserve Bank of Chicago (Colette A. Fried, Assistant... of Harbor Springs, Michigan; Tracy Irish Texter; Tracy Irish Texter; John F. Texter, as trustees of the John F. Texter and Tracy I. Texter Trust; the John F. Texter and Tracy I. Texter Trust, all of...
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2010-06-09
... June 23, 2010. A. Federal Reserve Bank of Chicago (Colette A. Fried, Assistant Vice President) 230 South LaSalle Street, Chicago, Illinois 60690-1414: 1. John V. Tippmann, Sr., as an individual, and John V. Tippman, Sr.; John and Helen McCarthy; Richard and Sally Ley; John Tippman, Jr.; Patrick Tippman...
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2010-07-01
..., 2010. A. Federal Reserve Bank of Chicago (Colette A. Fried, Assistant Vice President) 230 South LaSalle Street, Chicago, Illinois 60690-1414: 1. John V. Tippmann, Sr., as an individual; John V. Tippmann, Sr.; John and Helen McCarthy; Richard and Sally Ley; John Tippmann, Jr.; Patrick Tippmann; and Brian and...
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2013-04-11
... April 26, 2013. A. Federal Reserve Bank of Chicago (Colette A. Fried, Assistant Vice President) 230 South LaSalle Street, Chicago, Illinois 60690-1414: 1. MBG Investors I, LP, Mexico City, Mexico, and its... Pablo del Valle Perochena, Ignacio del Valle Ruiz and Adolfo del Valle Ruiz, all of Mexico City, Mexico...
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African Journals Online (AJOL)
Geo
l'estuaire du fleuve Comoé (Grand-Bassam, Côte d'Ivoire). Kouassi Laurent ADOPO1*, Apie Colette AKOBE1, Etche Mireille AMANI2,. Sylvain MONDE3 et Kouamé AKA3. (1)Laboratoire de Géologie Marine, Sédimentologie et Environnement, Centre de Recherche en Ecologie,. Université Felix Houphouet Boigny Abidjan, ...
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2012-12-03
... December 18, 2012. A. Federal Reserve Bank of Chicago (Colette A. Fried, Assistant Vice President) 230... David H. Irish Trust, all of Harbor Springs, Michigan; Tracy Irish Texter, John F. Texter, as trustees of the John F. Texter and Tracy I. Texter Trust; the John F. Texter and Tracy I. Texter Trust, all of...
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DEFF Research Database (Denmark)
Jensen, Niels Rosendal
2014-01-01
Anmeldelsen gennemgår Colette Bec's analyse af fransk sociallovgivning fra 1890'erne til 1980'erne. Den fremhæver især, at Bec's forklaring på krisen i socialpolitikken ikke kun trækker på eksterne faktorer, men derimod lægger vægt på, at selve socialpolitikken efter 1945 var udtryk for indbygged...
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Obésité abdominale et autres biomarqueurs de risque ...
African Journals Online (AJOL)
Obésité abdominale et autres biomarqueurs de risque cardiométabolique: influence du niveau socioéconomique et du mode de vie dans deux populations noires apparentées, Cotonou (Bénin) et Port-au-Prince (Haïti). Asma EL Mabchour, Hélène Delisle, Colette Vilgrain, Phillipe Larco, Roger Sodjinou ...
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Kabrita, Colette S; Hajjar-Mu?a, Theresa A
2016-01-01
Colette S Kabrita,1 Theresa A Hajjar-Muça,2 1Department of Sciences, 2Department of Mathematics and Statistics, Faculty of Natural and Applied Sciences, Notre Dame University – Louaize, Zouk Mosbeh, Lebanon Abstract: Good sleep quality and quantity are fundamental to the maintenance of normal physiological processes. Changes in sleep patterns are commonly observed among young adults and are shown to impact neurocognitive, academic, and psychological well-being. Given the ...
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Kabrita, Colette S; Hajjar-Muça, Theresa A; Duffy, Jeanne F
2014-01-01
Colette S Kabrita,1 Theresa A Hajjar-Muça,2 Jeanne F Duffy31Department of Sciences, 2Department of Mathematics and Statistics, Faculty of Natural and Applied Sciences, Notre Dame University – Louaize, Zouk Mosbeh, Lebanon; 3Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USAAbstract: Adequate, good night sleep is fundamental to well-being and is known to be influenced by myriad biological and en...
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Emilia Pardo Bazán journaliste : entre littérature et presse (1876-1921
Directory of Open Access Journals (Sweden)
Emilia Pérez Romero
2012-03-01
Full Text Available Thèse réalisée sous la direction de Mme Colette Rabaté (Université François Rabelais, Tours et soutenue devant un jury composé, en outre, de Mesdames et Messieurs Bénédicte Vauthier (Université de Tours, Dolores Thion Soriano-Mollá (Université de Pau, Jean-René Aymes (Université Paris-iii et José Manuel González Herrán (Université de Santiago de Compostela.
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Triple co-culture cell model as an in vitro model for oral particulate vaccine systems
DEFF Research Database (Denmark)
Nielsen, Line Hagner; De Rossi, C.; Lehr, C.-M.
the immunostimulatory ability of particulate vaccine formulations designed for oral delivery. Levels of cytokine production in response to vaccine administration were measured following particulate vaccine administration, as an indication of dendritic cell and macrophage activation. Precursors of cubosomes containing......; this was not observed with ovalbumin and blank solution. An example of the results is shown in Figure 2 for IL-17A. An established co-culture of Caco-2, THP-1 and MUTZ-3 cells showed promise as an in vitro model for testing of oral vaccine formulations. Mobility of co-culture immune cells as well as cytokine production...... with particle formulations. This was not the case when incubating with ovalbumin solution or blank. The ELISA screening assay showed production of a wide range of cytokines following culture incubation with cubosomes (with and without ovalbumin) and LPS solutions, indicative of a stimulatory effect...
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Evidence for volcanism in NW Ishtar Terra, Venus
International Nuclear Information System (INIS)
Gaddis, L.; Greeley, R.
1989-01-01
Venera 15/16 radar data for an area in NW Ishtar Terra, Venus, show an area with moderate radar return and a smooth textured surface which embays low lying areas of the surrounding mountainous terrain. Although this unit may be an extension of the lava plains of Lakshmi Planum to the southeast, detailed study suggests a separate volcanic center in NW Ishtar Terra. Lakshmi Planum, on the Ishtar Terra highland, exhibits major volcanic and tectonic features. On the Venera radar image radar brightness is influenced by slope and roughness; radar-facing slopes (east-facing) and rough surfaces (approx. 8 cm average relief) are bright, while west-facing slopes and smooth surfaces are dark. A series of semi-circular features, apparently topographic depressions, do not conform in orientation to major structural trends in this region of NW Ishtar Terra. The large depression in NW Ishtar Terra is similar to the calderas of Colette and Sacajawea Paterae, as all three structures are large irregular depressions. NW Ishtar Terra appears to be the site of a volcanic center with a complex caldera structure, possibly more than one eruptive vent, and associated lobed flows at lower elevations. The morphologic similarity between this volcanic center and those of Colette and Sacajawea suggests that centralized eruptions have been the dominant form of volcanism in Ishtar. The location of this volcanic center at the intersection of two major compressional mountain belts and the large size of the calders (with an inferred larg/deep magma source) support a crustal thickening/melting rather than a hot-spot origin for these magmas
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Lesly Bessière, Les romancières françaises, 1870-1900 : approche à travers l'exemple de Jeanne Marni
Directory of Open Access Journals (Sweden)
Lesly Bessière
2008-06-01
Full Text Available Les romancières françaises publiant entre 1870 et 1900, entre George Sand et Colette, sont les grandes oubliées des histoires littéraires ainsi que de l’historiographie. Leurs vies et leurs œuvres méritent pourtant d’être redécouvertes.Depuis les virulents textes misogynes de la fin du XIXe siècle signés Barbey d’Aurevilly, Albert Cim ou encore Dumas fils, « les bas-bleus » n’ont plus guère intéressé l’historiographie. Peu d’historiens y consacrent des ouvrages avant les études pluridisciplin...
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Triple co-culture cell model as an in vitro model for oral particulate vaccine systems
DEFF Research Database (Denmark)
Nielsen, Line Hagner; De Rossi, C.; Lehr, C-M.
; this was not observed with ovalbumin and blank solution. An example of the results is shown in Figure 2 for IL-17A. An established co-culture of Caco-2, THP-1 and MUTZ-3 cells showed promise as an in vitro model for testing of oral vaccine formulations. Mobility of co-culture immune cells as well as cytokine production......A triple co-culture cell model of Caco-2 cells, dendritic cells and macrophages (Figure 1) has previously been developed for studying intestinal permeability in a state of inflammation [1],[2]. The aim of this study was to investigate the applicability of this cell model for testing...... the model antigen ovalbumin was spray dried to obtain a particulate vaccine model system for testing in the cell model. The precursors were shown to form cubosomes when dispersed in aqueous medium, and was therefore used as the vaccine formulation for testing on the co-cultures. After 11 days, the TEER...
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Anne-Laure Dotte, Valelia Muni Toke, Jean Sibille, dirs,
Saint-Gerand, Jacques-Philippe
2014-01-01
La Délégation générale à la langue française et aux langues de France (dglflf) a organisé à Lyon, les 22 et 23 janvier 2010, deux journées d’étude sur le thème servant d’intitulé à l’ouvrage et le volume présente les résultats de ces journées. Les deux premières contributions ont pour thème les langues en danger. Dans « Langues en danger, idéologies, revitalisation » (pp. 15-32) Colette Grinevald et Michel Bert étudient le cas du rama, au Nicaragua, et montrent la force de l’impact idéologiqu...
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Reviews of recent publications
Directory of Open Access Journals (Sweden)
2009-06-01
Full Text Available Sara Lennox. Cemetery of the Murdered Daughters: Feminism, History, and Ingeborg Bachmann by Kristin T. Vander Lugt Birgit Tautz. Reading and Seeing Ethnic Differences in the Enlightenment: From China to Africa by Susanne Kelley Patrick Greaney. Untimely Beggar. Poverty and Power from Baudelaire to Benjamin by Christine Rinne Philip Payne, Graham Bartram, and Galin Tihanov, eds. A Companion to the Works of Robert Musil by Geoffrey C. Howes Jennifer Willging. Telling Anxiety: Anxious Narration in the Work of Marguerite Duras, Annie Ernaux, Nathalie Sarraute and Anne Hébert by Natalie Edwards Michael Lucey. Never Say I: Sexuality and the First Person in Colette, Gide, and Proust by Elissa Gelfand Anthony Waine. Changing Cultural Tastes. Writers and the Popular in Modern Germany by Katrin Völkner Susan Ireland and Patrice Proulx, eds. Textualizing the Immigrant Experience in Contemporary Quebec by Amy Hubbell Cristina Peri Rossi. State of Exile . Trans. Marilyn Buck. by Reina Ruiz
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Une affaire de femmes : la chanson comique en France
Directory of Open Access Journals (Sweden)
Isbelle Marc
2013-04-01
Full Text Available French female artists over the last century, including Yvette Guibert, Brigitte Fontaine, Colette Renard and Clarika, among many others, have successfully used different forms of humour in their songs. This article aims to study how feminine humour is created in the French chanson and how it evolves throughout time. Considering humour both as a means and as a consequence of feminine agency, it will explore symbolic and aesthetic issues related to humoristic chanson as regard to the creation of feminine identity in the French context. For that purpose, it will first address the specificities of the relation between women and music and between women and humour. Then, it will analyse several representative songs in this respect, such as Fais-moi mal, Johnny by Magali Noël, Déshabillez-moi by Juliette Gréco and Les crêpes aux champignons by Olivia Ruiz, among others. Drawing from these examples, humour will be regarded both as a means and as a consequence of feminine agency.
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El objeto a en los sueños de fin de análisis
Directory of Open Access Journals (Sweden)
Celeste Labaronnie
Full Text Available Resumen Este artículo se ubica en el marco del psicoanálisis lacaniano y su objetivo es la discusión de aportes teóricos sobre la plasmación del objeto a en los sueños de fin de análisis y su relación con el despertar. Se utilizan herramientas conceptuales de la disciplina para analizar cuatro contribuciones teóricas: la propuesta de Colette Soler de considerar la aparición del objeto a en algunos sueños como el punto de inserción de la pulsión, que conduce al despertar; los desarrollos de Ricardo Nepomiachi acerca de la plasmación onírica del vaciamiento del objeto a; la relación entre el objeto y el despertar sin angustia destacado por Frida Nemirovsky y Fabián Naparstek; y la noción de sueños-índice, postulada por Marcelo Mazzuca, en los cuales el objeto se inserta en una trama onírica, según una relación establecida entre deseo y satisfacción en determinado momento del análisis.
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Reviews of recent publications
Directory of Open Access Journals (Sweden)
1996-06-01
Full Text Available Anderson, Stephanie. Le Discours Féminin de Marguerite Duras by Julia Lauer-Chéenne Booker, M. Keith. Literature and Domination: Sex, Knowledge, and Power in Modern Fiction by Frédérique Chevillot Chevillot, Frédérique. La Réouverture du texte by Susan Ireland Cixous, Hélène. Three Steps on the Ladder of Writing by Jeff Schneider Descombes, Vincent. The Barometer of Modern Reason: On the Philosophies of Current Events by André Pierre Colombat Holmgren, Beth. Women's Works in Stalin's Time: On Lidiia Chukovskaia and Nadezhda Mandelstam by Serafima Roll Lyotard, Jean François. Political Writings . Trans. Bill Readings and Kevin Paul Geiman by Ronald Bogue McPherson, Karen S. Incriminations: Guilty Women/Telling Stories by Colette Hall Melnick, Daniel C. Fullness of Dissonance. Modern Fiction and the Aesthetics of Music by Walter A. Strauss Scatton, Linda Hart. Mikhail Zoshchenko: Evolution of a Writer by Eric Lozowy Sollers, Philippe. Watteau in Venice by T. Douglas Doyle Steele, Cynthia. Politics, Gender, and the Mexican Novel, 1968-1988: Beyond the Pyramid by Jill S. Kuhnheim Webb, Barbara J. Myth and History in Caribbean Fiction. Alejo Carpentier, Wilson Harris and Eduard Glissant by Nicasio Urbina
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An update on the management of peripheral T-cell lymphoma and emerging treatment options
Directory of Open Access Journals (Sweden)
Phillips AA
2011-09-01
Full Text Available Adrienne A Phillips1, Colette Owens2, Sangmin Lee1, Govind Bhagat31Division of Medical Oncology, Department of Medicine, 2Division of General Medicine, Department of Medicine, 3Department of Pathology and Cell Biology, Columbia University Medical Center and New York Presbyterian Hospital, Columbia University, New York, NY, USAAbstract: Peripheral T-cell lymphomas (PTCLs comprise a rare and heterogeneous subset of non-Hodgkin’s lymphomas (NHLs that arise from post-thymic T-cells or natural killer (NK-cells at nodal or extranodal sites. Worldwide, PTCLs represent approximately 12% of all NHLs and the 2008 World Health Organization (WHO classification includes over 20 biologically and clinically distinct T/NK-cell neoplasms that differ significantly in presentation, pathology, and response to therapy. Because of the rarity and heterogeneity of these diseases, large clinical trials have not been conducted and optimal therapy is not well defined. Most subtypes are treated with similar combination chemotherapy regimens as used for aggressive B-cell NHL, but with poorer outcomes. New treatment combinations and novel agents are currently being explored for PTCLs and this review highlights a number of options that appear promising.Keywords: treatment, non-Hodgkin’s lymphoma, novel therapy, natural-killer cells
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International Nuclear Information System (INIS)
Galvao dos Santos, G.; Reinders, J.; Ouwehand, K.; Rustemeyer, T.; Scheper, R.J.; Gibbs, S.
2009-01-01
Allergic contact dermatitis is the result of an adaptive immune response of the skin to direct exposure to an allergen. Since many chemicals are also allergens, European regulations require strict screening of all ingredients in consumer products. Until recently, identifying a potential allergen has completely relied on animal testing (e.g.: Local Lymph Node Assay). In addition to the ethical problems, both the 7th Amendment to the Cosmetics Directive and REACH have stimulated the development of alternative tests for the assessment of potential sensitizers. This review is aimed at summarising the progress on cell based assays, in particular dendritic cell based assays, being developed as animal alternatives. Primary cells (CD34 + derived dendritic cells, monocyte derived dendritic cells) as well as dendritic cell-like cell lines (THP-1, U-937, MUTZ-3, KG-1, HL-60, and K562) are extensively described along with biomarkers such as cell surface markers, cytokines, chemokines and kinases. From this review, it can be concluded that no single cell based assay nor single marker is yet able to distinguish all sensitizers from non-sensitizers in a test panel of chemicals, nor is it possible to rank the sensitizing potential of the test chemicals. This suggests that sensitivity and specificity may be increased by a tiered assay approach. Only a limited number of genomic and proteomic studies have been completed until now. Such studies have the potential to identify novel biomarkers for inclusion in future assay development. Although progress is promising, this review suggests that it may be difficult to meet the up and coming European regulatory deadlines.
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Directory of Open Access Journals (Sweden)
Albrekt Ann-Sofie
2011-08-01
Full Text Available Abstract Background Allergic contact dermatitis is an inflammatory skin disease that affects a significant proportion of the population. This disease is caused by an adverse immune response towards chemical haptens, and leads to a substantial economic burden for society. Current test of sensitizing chemicals rely on animal experimentation. New legislations on the registration and use of chemicals within pharmaceutical and cosmetic industries have stimulated significant research efforts to develop alternative, human cell-based assays for the prediction of sensitization. The aim is to replace animal experiments with in vitro tests displaying a higher predictive power. Results We have developed a novel cell-based assay for the prediction of sensitizing chemicals. By analyzing the transcriptome of the human cell line MUTZ-3 after 24 h stimulation, using 20 different sensitizing chemicals, 20 non-sensitizing chemicals and vehicle controls, we have identified a biomarker signature of 200 genes with potent discriminatory ability. Using a Support Vector Machine for supervised classification, the prediction performance of the assay revealed an area under the ROC curve of 0.98. In addition, categorizing the chemicals according to the LLNA assay, this gene signature could also predict sensitizing potency. The identified markers are involved in biological pathways with immunological relevant functions, which can shed light on the process of human sensitization. Conclusions A gene signature predicting sensitization, using a human cell line in vitro, has been identified. This simple and robust cell-based assay has the potential to completely replace or drastically reduce the utilization of test systems based on experimental animals. Being based on human biology, the assay is proposed to be more accurate for predicting sensitization in humans, than the traditional animal-based tests.
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2011-01-01
Background Allergic contact dermatitis is an inflammatory skin disease that affects a significant proportion of the population. This disease is caused by an adverse immune response towards chemical haptens, and leads to a substantial economic burden for society. Current test of sensitizing chemicals rely on animal experimentation. New legislations on the registration and use of chemicals within pharmaceutical and cosmetic industries have stimulated significant research efforts to develop alternative, human cell-based assays for the prediction of sensitization. The aim is to replace animal experiments with in vitro tests displaying a higher predictive power. Results We have developed a novel cell-based assay for the prediction of sensitizing chemicals. By analyzing the transcriptome of the human cell line MUTZ-3 after 24 h stimulation, using 20 different sensitizing chemicals, 20 non-sensitizing chemicals and vehicle controls, we have identified a biomarker signature of 200 genes with potent discriminatory ability. Using a Support Vector Machine for supervised classification, the prediction performance of the assay revealed an area under the ROC curve of 0.98. In addition, categorizing the chemicals according to the LLNA assay, this gene signature could also predict sensitizing potency. The identified markers are involved in biological pathways with immunological relevant functions, which can shed light on the process of human sensitization. Conclusions A gene signature predicting sensitization, using a human cell line in vitro, has been identified. This simple and robust cell-based assay has the potential to completely replace or drastically reduce the utilization of test systems based on experimental animals. Being based on human biology, the assay is proposed to be more accurate for predicting sensitization in humans, than the traditional animal-based tests. PMID:21824406
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Hydrogen production processes; Procedes de production d'hydrogene
Energy Technology Data Exchange (ETDEWEB)
NONE
2003-07-01
The goals of this first Gedepeon workshop on hydrogen production processes are: to stimulate the information exchange about research programs and research advances in the domain of hydrogen production processes, to indicate the domains of interest of these processes and the potentialities linked with the coupling of a nuclear reactor, to establish the actions of common interest for the CEA, the CNRS, and eventually EDF, that can be funded in the framework of the Gedepeon research group. This document gathers the slides of the 17 presentations given at this workshop and dealing with: the H{sub 2} question and the international research programs (Lucchese P.); the CEA's research program (Lucchese P., Anzieu P.); processes based on the iodine/sulfur cycle: efficiency of a facility - flow-sheets, efficiencies, hard points (Borgard J.M.), R and D about the I/S cycle: Bunsen reaction (Colette S.), R and D about the I/S cycle: the HI/I{sub 2}/H{sub 2}O system (Doizi D.), demonstration loop/chemical engineering (Duhamet J.), materials and corrosion (Terlain A.); other processes under study: the Westinghouse cycle (Eysseric C.), other processes under study at the CEA (UT3, plasma,...) (Lemort F.), database about thermochemical cycles (Abanades S.), Zn/ZnO cycle (Broust F.), H{sub 2} production by cracking, high temperature reforming with carbon trapping (Flamant G.), membrane technology (De Lamare J.); high-temperature electrolysis: SOFC used as electrolyzers (Grastien R.); generic aspects linked with hydrogen production: technical-economical evaluation of processes (Werkoff F.), thermodynamic tools (Neveu P.), the reactor-process coupling (Aujollet P.). (J.S.)
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Choses vues, choses lues : le reportage à l'épreuve de l'intertexte
Directory of Open Access Journals (Sweden)
Myriam Boucharenc
2006-09-01
Full Text Available Le reportage qui s’impose dès la Belle Epoque comme le genre phare de la grande presse d’information, est en passe de devenir durant l’entre-deux-guerres un nouveau genre littéraire : la tentation de l’enquête touche alors un nombre considérable d’écrivains et non des moindres – Colette, Cendrars, Dorgelès, Carco, Soupault, Vailland... – pour n’en citer que quelques-uns. L’ambiguïté du genre tient notamment à sa double postulation, l’une vers la littéralité (la soumission à la « chose vue », l’autre vers la littérarité : la chose « écrite » mais aussi « lue ». Partant, le reportage entretient un rapport hésitant et duplice avec le jeu intertextuel qui, variablement assumé, semble remplir différentes fonctions parmi lesquelles une fonction polémique (de démarcation par rapport aux genres mitoyens du roman d’aventures et du récit de voyage, une fonction poétique s’exerçant dans le paradigme restreint d’un genre à la recherche de ses rituels d’écriture propres, une fonction génétique enfin, dans la mesure où l’œuvre de l’écrivain bien souvent s’amorce, se poursuit ou se réfléchit dans l’écriture du reportage.
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All Christians? Experiences of science educators in Northern Ireland
Murphy, Colette; Hickey, Ivor; Beggs, Jim
2010-03-01
In this paper we respond to Staver's article (this issue) on an attempt to resolve the discord between science and religion. Most specifically, we comment on Staver's downplaying of difference between Catholics and Protestants in order to focus on the religion-science question. It is our experience that to be born into one or other of these traditions in some parts of the world (especially Northern Ireland) resulted in starkly contrasting opportunities, identities and practices in becoming and being science educators. The paper starts with a short contextual background to the impact of religion on schooling and higher education in Northern Ireland. We then explore the lives and careers of three science/religious educators in Northern Ireland: Catholic (Jim) and Protestant (Ivor) males who are contemporaries and whose experience spans pre-Troubles to post-conflict and a Catholic female (Colette) who moved to Northern Ireland during the Troubles as a teenager. Finally, we discuss the situation regarding the teaching of creationism and evolution in Northern Ireland—an issue has recently generated high public interest. The Chair of the Education Committee of the Northern Ireland Assembly recently stated that "creationism is not for the RE class because I believe that it can stand scientific scrutiny and that is a debate which I am quite happy to encourage and be part of…" (News Letter 2008). It could be the case that the evolution debate is being fuelled as a deliberate attempt to undermine some of the post-conflict collaboration projects between schools and communities in Northern Ireland.
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International Nuclear Information System (INIS)
2003-01-01
The goals of this first Gedepeon workshop on hydrogen production processes are: to stimulate the information exchange about research programs and research advances in the domain of hydrogen production processes, to indicate the domains of interest of these processes and the potentialities linked with the coupling of a nuclear reactor, to establish the actions of common interest for the CEA, the CNRS, and eventually EDF, that can be funded in the framework of the Gedepeon research group. This document gathers the slides of the 17 presentations given at this workshop and dealing with: the H 2 question and the international research programs (Lucchese P.); the CEA's research program (Lucchese P., Anzieu P.); processes based on the iodine/sulfur cycle: efficiency of a facility - flow-sheets, efficiencies, hard points (Borgard J.M.), R and D about the I/S cycle: Bunsen reaction (Colette S.), R and D about the I/S cycle: the HI/I 2 /H 2 O system (Doizi D.), demonstration loop/chemical engineering (Duhamet J.), materials and corrosion (Terlain A.); other processes under study: the Westinghouse cycle (Eysseric C.), other processes under study at the CEA (UT3, plasma,...) (Lemort F.), database about thermochemical cycles (Abanades S.), Zn/ZnO cycle (Broust F.), H 2 production by cracking, high temperature reforming with carbon trapping (Flamant G.), membrane technology (De Lamare J.); high-temperature electrolysis: SOFC used as electrolyzers (Grastien R.); generic aspects linked with hydrogen production: technical-economical evaluation of processes (Werkoff F.), thermodynamic tools (Neveu P.), the reactor-process coupling (Aujollet P.). (J.S.)
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Schaaf, Wolfgang
2015-04-01
Lignite mining in Lusatia has a history of over 100 years. Open-cast mining directly affected an area of 1000 km2. Since 20 years we established an ecosystem oriented approach to evaluate the development and site characteristics of post-mining areas mainly restored for agricultural and silvicultural land use. Water and element budgets of afforested sites were studied under different geochemical settings in a chronosequence approach (Schaaf 2001), as well as the effect of soil amendments like sewage sludge or compost in restoration (Schaaf & Hüttl 2006). Since 10 years we also study the development of natural site regeneration in the constructed catchment Chicken Creek at the watershed scale (Schaaf et al. 2011, 2013). One of the striking characteristics of post-mining sites is a very large small-scale soil heterogeneity that has to be taken into account with respect to soil forming processes and element cycling. Results from these studies in combination with smaller-scale process studies enable to evaluate the long-term effect of restoration measures and adapted land use options. In addition, it is crucial to compare these results with data from undisturbed, i.e. non-mined sites. Schaaf, W., 2001: What can element budgets of false-time series tell us about ecosystem development on post-lignite mining sites? Ecological Engineering 17, 241-252. Schaaf, W. and Hüttl, R. F., 2006: Direct and indirect effects of soil pollution by lignite mining. Water, Air and Soil Pollution - Focus 6, 253-264. Schaaf, W., Bens, O., Fischer, A., Gerke, H.H., Gerwin, W., Grünewald, U., Holländer, H.M., Kögel-Knabner, I., Mutz, M., Schloter, M., Schulin, R., Veste, M., Winter, S. & Hüttl, R.F., 2011: Patterns and processes of initial terrestrial-ecosystem development. Journal of Plant Nutrition and Soil Science, 174, 229-239. Schaaf, W., Elmer, M., Fischer, A., Gerwin, W., Nenov, R., Pretsch, H. and Zaplate, M.K., 2013: Feedbacks between vegetation, surface structures and hydrology
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Poetics of Disintegration in Laure’s “Poems before the summer of 1936”
Directory of Open Access Journals (Sweden)
Barbara Ann Brown
2011-01-01
Full Text Available This article examines issues of grammatical gender and symbol in the poetry of Colette Laure Lucienne Peignot. I have focused on the poetics of disintegration in the section entitled "Poems before the summer of 1936," in which we encounter a number of poems written in free verse that reflect different aspects of Laure's notion of the poetic sacred. The poetic sacred, for Laure, relates to the moment when the eternal part of a human being becomes actualized via the engagement of fulfilling a goal while simultaneously being aware of the "weight of death." For Laure, if a person cannot or can no longer experience this emotion, then the person's life is deprived of meaning, deprived of the sacred. Many of the poems in "Poems before the summer of 1936" recount journeys that the speaker, or statement subject "I," embarks upon. Great attention is paid to the grammatical gender of the statement subjects in these poems, although, at times, grammatical gender can be difficult to determine. Sometimes grammatical gender can be discerned in the past tense forms of verbs in the French language, and other times it can be determined by Laure's use of masculine or feminine rhymes in her work. But often, Laure conceals the gender of her statement subjects, choosing instead to focus on represent a rejection of traditional gender roles in her poetry. Ultimately, this article seeks to posit Laure among France's best known writers and thinkers in the early part of the twentieth century, to help close the huge gap in the canon left by the absence of women writers and thinkers between the years 1880-1930.
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From Narcissus to Genius through the Work of Pleshette DeArmitt
Directory of Open Access Journals (Sweden)
Marygrace Hemme
2015-12-01
Full Text Available Through my reading of the section of Pleshette Dearmitt’s book The Right to Narcissism, entitled “Kristeva: the Rebirth of Narcissus,” I illustrate the way in which DeArmitt’s reading of Narcissus is reflected in Julia Kristeva’s conception of genius. DeArmitt describes narcissism as a structure through which subjectivity, language, self-love, and love for the other come about. Narcissism develops through a metaphorical relation of identification with a “loving third” in which the subject-in-formation is transferred to the site of the other, to the place from which he or she is seen and heard through the words of the mother directed at an other. The emerging subject catches the words of others and repeats them. The speech of the other, then, is a model or pattern with which the subject-in-formation identifies repeatedly, and it is through identifying with the third that the forming subject becomes like the other, a speaking subject herself. All love comes from narcissism because it is a repetition of this identification and transference. I connect this account to Kristeva’s Female Genius Trilogy by claiming that these works are love stories since they are based on a repetition of the narcissistic structure on a cultural level in their content and in their form, though for each genius it manifests through a different register. For Hannah Arendt the relation is between the actor and the spectator; for Melanie Klein it is between the analyst and the analysand; and for Colette it is between the writer and the reader.
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Geologic map of the Lakshmi Planum quadrangle (V-7), Venus
Ivanov, Mikhail A.; Head, James W.
2010-01-01
contractional structures such as ridges. Corona and corona-like structures are not typical features of this zone but occur within separate branches of extensional structures oriented radial to the edge of Lakshmi. The southeastern edge of Lakshmi appears to be the source of large volcanic flows that extend to the south toward the lowland areas of Sedna Planitia. Colette and Sacajawea Paterae in the interior of Lakshmi are low volcanic centers with very deep central depressions. Lava flows sourced by Colette and Sacajawea form distinctive radial patterns around these volcanoes. Magellan gravity data show that the northern and northeastern portions of the quadrangle, which correspond to Lakshmi Planum, represent a significant geoid anomaly with the peak value of about 90 m over Maxwell Montes at the eastern edge of the map area. Maxwell is characterized also by very high vertical gravity acceleration values (as much as 268 mGal). The lowland of Sedna Planitia to the south of Lakshmi has mostly negative geoid values (down to -40 m). The key geological structure of the quadrangle is Lakshmi Planum, the mode of formation of which is still a major unresolved problem. The topographic configuration, gravity signature, and pattern of deformation inside Lakshmi and along its boundaries make this feature unique on Venus. Thus, geological mapping of this region allows addressing several important questions that should help to put some constraints on the existing models of Lakshmi formation. What is the sequence of events in the formation and evolution of such a unique morphologic and topographic feature? What are the characteristics of the marginal areas of Lakshmi: the compact mountain belts and broad zones of deformation in the transition zone between Lakshmi and surrounding lowlands? How do the units in Lakshmi Planum quadrangle compare with the units mapped in neighboring and distant regions of Venus and what information do they provide concerning models for Venus
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Nature's Mechanisms for Tough, Self-healing Polymers and Polymer Adhesives
Hansma, Paul
2007-03-01
Spider silk^2 and the natural polymer adhesives in abalone shells^3 and bone^4,5 can give us insights into nature's mechanisms for tough, self-healing polymers and polymer adhesives. The natural polymer adhesives in biomaterials have been optimized by evolution. An optimized polymer adhesive has five characteristics. 1) It holds together the strong elements of the composite. 2) It yields just before the strong elements would otherwise break. 3) It dissipates large amounts of energy as it yields. 4) It self heals after it yields. 5) It takes just a few percent by weight. Both natural polymer adhesives and silk rely on sacrificial bonds and hidden length for toughness and self-healing.^6 A relatively large energy, of order 100eV, is required to stretch a polymer molecule after a weak bond, a sacrificial bond, breaks and liberates hidden length, which was previously hidden, typically in a loop or folded domain, from whatever was stretching the polymer. The bond is called sacrificial if it breaks at forces well below the forces that could otherwise break the polymer backbone, typically greater than 1nN. In many biological cases, the breaking of sacrificial bonds has been found to be reversible, thereby also providing a ``self-healing'' property to the material.^2-4 Individual polymer adhesive molecules based on sacrificial bonds and hidden length can supply forces of order 300pN over distances of 100s of nanometers. Model calculations show that a few percent by weight of adhesives based on these principles could be optimized adhesives for high performance composite materials including nanotube and graphene sheet composites. ^2N. Becker, E. Oroudjev, S. Mutz et al., Nature Materials 2 (4), 278 (2003). ^3B. L. Smith, T. E. Schaffer, M. Viani et al., Nature 399 (6738), 761 (1999). ^4J. B. Thompson, J. H. Kindt, B. Drake et al., Nature 414 (6865), 773 (2001). ^5G. E. Fantner, T. Hassenkam, J. H. Kindt et al., Nature Materials 4, 612 (2005). ^6G. E. Fantner, E. Oroudjev, G
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Directory of Open Access Journals (Sweden)
Nicholson WC
2017-06-01
Full Text Available William C Nicholson, Mirjam-Colette Kempf, Linda Moneyham, David E Vance School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA Abstract: Depression is the most common comorbidity and neuropsychiatric complication in HIV. Estimates suggest that the prevalence rate for depression among HIV-infected individuals is three times that of the general population. The association between HIV and clinical depression is complex; however, chronic activation of inflammatory mechanisms, which disrupt central nervous system (CNS function, may contribute to this association. Disruptions in CNS function can result in cognitive disorders, social withdrawal, fatigue, apathy, psychomotor impairment, and sleep disturbances, which are common manifestations in depression and HIV alike. Interestingly, the parasympathetic system-associated vagus nerve (VN has primary homeostatic properties that restore CNS function following a stress or inflammatory response. Unfortunately, about 30% of adults with HIV are resistant to standard psychotherapeutic and psychopharmacological treatments for depression, thus suggesting the need for alternative treatment approaches. VN stimulation (VNS and its benefits as a treatment for depression have been well documented, but remain unexplored in the HIV population. Historically, VNS has been delivered using a surgically implanted device; however, transcutanous VNS (tVNS with nonsurgical auricular technology is now available. Although it currently lacks Food and Drug Administration approval in the US, evidence suggests several advantages of tVNS, including a reduced side-effect profile when compared to standard treatments and comparable results to implantable VNS in treating depression. Therefore, tVNS could offer an alternative for managing depression in HIV via regulating CNS function; moreover, tVNS may be useful for treatment of other symptoms common in HIV. From this, implications for nursing research and practice
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International Nuclear Information System (INIS)
Seki, Masayuki; Ishibashi, Fujio; Kono, Syusaku; Hirako, Kazuhito; Tsukada, Tatsuya
2003-04-01
Irradiation test in BOR-60 at RIAR to judge practical use prospect of ODS cladding tube at early stage is planned as Japan-Russia a joint research. RIAR does fuel design of fuel pin used for this joint research. JNC manufactures ODS cladding tube and bar materials (two steel kind of martensite and ferrite), upper endplug production. They are welded by pressurized resistance welding, and are inspected in JNC Tokai, transported to RIAR. And RIAR manufactures vibration packing fuel pin. On the upper endplug welding by pressurized resistance welding method, we worded on the problems such as decision of welding condition by changing the size and crystallization of cladding tube and the design of endplug, and the chucking device remodeling to correspond to the long scale cladding tube welding system (included handling) and of quality assurance method. Especially, use of long scale cladding tube caused problem that bending transformation occurred in cladding tube by welding pressure. However, we solved this problem by shortening the distance of cladding tube colette chuck and pressure receiving, and by putting the sleeve in an internal space of welding machine, losing the bending of cladding tube. Moreover, welding defects were occurred by the difference of an inside state, an inside defect and recrystallization of cladding tube. We solved the problem by inside grinding for the edge of tube, angle beam method by ultrasonic wave, and ultrasonic wave form confirmation. Manufacturing process with long scale cladding tube including heat-treatment to remove combustion return and remaining stress was established besides, Afterwards, welding of ODS cladding tube and upper endplug. As the quality assurance system, we constructed [Documented procedure (referred to JOYO)] based on [Document of the QA plan] by OEC. Welding and inspection were executed by the document procedure. It is thought that the quality assurance method become references for the irradiation test in JOYO in the
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Status of funded actions; Bilan des actions soutenues
Energy Technology Data Exchange (ETDEWEB)
NONE
2003-07-01
The GEDEPEON status workshop is organised to review the GEDEPEON research actions, which have been funded in 2003. Presentations are made by research teams actively involved in GEDEPEON research areas. Speakers were invited to show how the presented research data are related to the general goals of transmutation, for which 2006 is an important milestone, and innovative systems. This document gathers 18 presentations (slides) among the 32 given at this workshop and dealing with: 1 - nuclear data: measurement of cross-sections of neutron induced reactions at the nTof time of flight facilities of CERN and of Gelina at Geel (F. Gunsing), study of (n,xn) reactions thanks to prompt gamma spectroscopy (M. Kerveno), iodine 129 cross-sections (G. Noguere); 2 - reactor physics/cycles: CEA-CNRS scenarios (F. Varaine, D. Heuer), analysis of uncertainties and sensitivity factors of nuclear data on innovative systems (molten-salt reactors) (A. Bidaud); 3 - materials: contribution to the study of T91 steel fatigue by lead-bismuth (D. Gorse), kinetics and mechanisms of fatigue by liquid metals (V. Laporte), studies of molten salts corrosion in future reactors (S. Sanchez), stress-induced fatigue by liquid metal (A. Verleene), thermodynamic study of the Bi-Fe-Hg-O-Pb quinary system (A. Maitre), synchrotron imaging study of fatigue by liquid metals (D. Bellet); 4 - future systems: molten salts reprocessing strategy - impact on the molten salt reactors neutronics (L. Mathieu), microscopy technique for the characterization of the thermal properties of inert materials for gas-cooled reactors (L. David), modeling and application of sub-atomic phenomena (J. Maillard), forecasting of the chemical compatibility between fissile compounds and inert materials in future high temperature reactors using a thermodynamical approach (A. Maitre), hydrogen production by thermochemical cycles (S. Colette), development of Ni-W refractory alloys for high temperature and molten salts reactors (J
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International Nuclear Information System (INIS)
2003-01-01
The GEDEPEON status workshop is organised to review the GEDEPEON research actions, which have been funded in 2003. Presentations are made by research teams actively involved in GEDEPEON research areas. Speakers were invited to show how the presented research data are related to the general goals of transmutation, for which 2006 is an important milestone, and innovative systems. This document gathers 18 presentations (slides) among the 32 given at this workshop and dealing with: 1 - nuclear data: measurement of cross-sections of neutron induced reactions at the nTof time of flight facilities of CERN and of Gelina at Geel (F. Gunsing), study of (n,xn) reactions thanks to prompt gamma spectroscopy (M. Kerveno), iodine 129 cross-sections (G. Noguere); 2 - reactor physics/cycles: CEA-CNRS scenarios (F. Varaine, D. Heuer), analysis of uncertainties and sensitivity factors of nuclear data on innovative systems (molten-salt reactors) (A. Bidaud); 3 - materials: contribution to the study of T91 steel fatigue by lead-bismuth (D. Gorse), kinetics and mechanisms of fatigue by liquid metals (V. Laporte), studies of molten salts corrosion in future reactors (S. Sanchez), stress-induced fatigue by liquid metal (A. Verleene), thermodynamic study of the Bi-Fe-Hg-O-Pb quinary system (A. Maitre), synchrotron imaging study of fatigue by liquid metals (D. Bellet); 4 - future systems: molten salts reprocessing strategy - impact on the molten salt reactors neutronics (L. Mathieu), microscopy technique for the characterization of the thermal properties of inert materials for gas-cooled reactors (L. David), modeling and application of sub-atomic phenomena (J. Maillard), forecasting of the chemical compatibility between fissile compounds and inert materials in future high temperature reactors using a thermodynamical approach (A. Maitre), hydrogen production by thermochemical cycles (S. Colette), development of Ni-W refractory alloys for high temperature and molten salts reactors (J
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Results of activities at the upgraded inspection and repair facility in Temelin NPP
International Nuclear Information System (INIS)
Samojlov, O.B.; Romanov, A.I.; Sholin, E.V.; Molchanov, V.L.
2010-01-01
Based on a contract signed between JSC TVEL and CEZ a.s., JSC TVEL provided additional equipment for the VVantage6 FA inspection and repair facility at the Temelin NPP to switch to TVSA-T inspection and repair. JSC TVEL analyzed the equipment (modules) of the Temelin NPP inspection and repair facility with focus on the compatibility of the current facility design and modules with the TVSA-T design. Based on the analysis, a set of modules and systems was identified, which were developed and manufactured or upgraded to ensure TVSA-T inspection and repair in the Temelin NPP facility. The set of modules and systems for TVSA-T inspection and repair included: (i) A guide to point the FA headpiece manipulator at the guide thimbles and to point the Cladding Integrity Monitoring (CIM) manipulator (which is part of the CIM System) at the upper end plugs; (ii) A guide grip to install the guide on the facility workstation table; (iii) An FA headpiece manipulator to detach, remove, install and attach the TVSA-T headpiece; (iv) A jig to point the upgraded fuel rod extraction tool at the upper end plug of the extracted fuel rod; (v) A colette and a locking tube to extract a fuel rod and install a displacer using the fuel rod extraction tool, which is part of the Temelin facility; (vi) A CIM system to detect leaky fuel rods. Pictures of the modules and of the fuel rod extraction tools are displayed, and the CIM system is described. The principle to detect leaky fuel rods is explained. In 2010, TVSA-T mockup repair tests were conducted in the Temelin NPP facility using earlier manufactured modules and systems. The following operations were performed during the tests: detaching and removal of the TVSA-T headpiece; detection of leaky fuel rod mockups; extraction of the fuel rod mockup and installation of the displacer in its place; installation and attaching of the TVSA-T headpiece. The installation of the following 2 TV systems is planned for 2011: a color non
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Directory of Open Access Journals (Sweden)
Kabrita CS
2016-06-01
Full Text Available Colette S Kabrita,1 Theresa A Hajjar-Muça,2 1Department of Sciences, 2Department of Mathematics and Statistics, Faculty of Natural and Applied Sciences, Notre Dame University – Louaize, Zouk Mosbeh, Lebanon Abstract: Good sleep quality and quantity are fundamental to the maintenance of normal physiological processes. Changes in sleep patterns are commonly observed among young adults and are shown to impact neurocognitive, academic, and psychological well-being. Given the scarcity of sleep information about Lebanon and acknowledging the sex differences in various sleep dimensions, we conducted a study that aimed at assessing sex differences in sleep habits among university students in Lebanon in relation to psychoacademic status. A total of 540 students (50.6% females completed a questionnaire that inquired about sociodemographics and evaluated sleep quality and depression using the Pittsburg Sleep Quality Index (PSQI and Center for Epidemiological Studies Depression Scale (CES-D, respectively. The mean PSQI global score (6.57±3.49 indicated poor sleep, with no significant differences between men and women. The sleep/wake rhythm was delayed on weekends for both sexes. Females exhibited earlier bedtimes and rise times and longer sleep durations on both weekdays and weekends. However, unlike males females showed a greater phase delay in wake times than bedtimes on weekends (149 minutes vs 74 minutes, respectively. In all, 70.9% of females suffered from depressive symptoms, which was a significantly higher proportion compared with 58.5% of males (P<0.01. Based on the mean cumulative self-reported grade point average (GPA, the academic performance of females was significantly better than that of males (2.8±0.61 vs 2.65±0.61, P<0.05, respectively. Depression, as scored by CES-D, in females was significantly negatively correlated with the cumulative GPA (r=-0.278, P<0.01, earlier wake time (r=-0.168, P<0.05, and average sleep duration (r=-0
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Directory of Open Access Journals (Sweden)
EL Mabchour A
2015-10-01
Full Text Available Asma EL Mabchour,1 Hélène Delisle,1 Colette Vilgrain,2 Philippe Larco,2 Roger Sodjinou,3 Malek Batal1 1Transition Nutritionnelle (TRANSNUT, WHO Collaborating Centre on Nutrition Changes and Development, Department of Nutrition, Faculty of Medicine, University of Montreal, Montreal, QC, Canada; 2Haitian Foundation for Diabetes and Cardiovascular Diseases (FHADIMAC, Port-au-Prince, Haiti; 3West Africa Health Organization (WAHO, Bobo-Dioulasso, Burkina Faso Purpose: Waist circumference (WC and waist-to-height ratio (WHtR are widely used as indicators of abdominal adiposity and the cut-off values have been validated primarily in Caucasians. In this study we identified the WC and WHtR cut-off points that best predicted cardiometabolic risk (CMR in groups of African (Benin and African ancestry (Haiti Black subjects. Methods: This cross-sectional study included 452 apparently healthy subjects from Cotonou (Benin and Port-au-Prince (Haiti, 217 women and 235 men from 25 to 60 years. CMR biomarkers were the metabolic syndrome components. Additional CMR biomarkers were a high atherogenicity index (total serum cholesterol/high density lipoprotein cholesterol ≥4 in women and ≥5 in men; insulin resistance set at the 75th percentile of the calculated Homeostasis Model Assessment index (HOMA-IR; and inflammation defined as high-sensitivity C-reactive protein (hsCRP concentrations between 3 and 10 mg/L. WC and WHtR were tested as predictors of two out of the three most prevalent CMR biomarkers. Receiver operating characteristic (ROC curves, Youden's index, and likelihood ratios were used to assess the performance of specific WC and WHtR cut-offs. Results: High atherogenicity index (59.5%, high blood pressure (23.2%, and insulin resistance (25% by definition were the most prevalent CMR biomarkers in the study groups. WC and WHtR were equally valid as predictors of CMR. Optimal WC cut-offs were 80 cm and 94 cm in men and women, respectively, which is exactly
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Directory of Open Access Journals (Sweden)
Kabrita CS
2014-01-01
Full Text Available Colette S Kabrita,1 Theresa A Hajjar-Muça,2 Jeanne F Duffy31Department of Sciences, 2Department of Mathematics and Statistics, Faculty of Natural and Applied Sciences, Notre Dame University – Louaize, Zouk Mosbeh, Lebanon; 3Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USAAbstract: Adequate, good night sleep is fundamental to well-being and is known to be influenced by myriad biological and environmental factors. Given the unavailability of sleep data about Lebanon, the cultural shifts and socioeconomic pressures that have affected many aspects of society, particularly for students and working adults, as well as our understanding of sleep in university students in other countries, we conducted a national study to assess sleep quality and factors contributing to sleep and general health in a culture-specific context. A self-filled questionnaire, inquiring about sociodemographics, health-risk behaviors, personal health, and evaluating sleep quality and chronotype using standard scales was completed by 540 students at private and public universities in Lebanon. Overall, they reported sleeping 7.95±1.34 hours per night, although 12.3% reported sleeping <6.5 hours and more than half scored in the poor-sleeper category on the Pittsburgh Sleep Quality Index (PSQI. Sleep timing differed markedly between weekdays and weekends, with bedtimes and wake-up times delayed by 1.51 and 2.43 hours, respectively, on weekends. While most scored in the "neither type" category on the Morningness–Eveningness Questionnaire (MEQ, 24.5% were evening types and 7.3% were morning types. MEQ score was significantly correlated with smoking behavior and daily study onset, as well as with PSQI score, with eveningness associated with greater number of cigarettes, later study times, and poor sleep. We conclude that the prevalence of poor sleep quality among Lebanese university students is associated
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Directory of Open Access Journals (Sweden)
Caren B. Scheepers
2011-08-01
Full Text Available Orientation: Human resource practices influence the psychological contract between employee and employer and, ultimately, organisational performance. Research purpose: The objective of this study was to examine the effect of human resource practices on the types of psychological contracts in an iron ore mining company in South Africa empirically. Motivation for the study: Although there have been a number of conceptual studies on the effect of human resource practices on psychological contracts, there has been no effort to synthesise the links between these contracts and various human resource practices systematically. This study endeavoured to provide quantitative evidence to verify or refute conceptual studies on this relationship. Its findings could inform human resource strategies and, ultimately, the prioritisation of human resource practices to improve the cost-effective allocation of resources. Research design, approach and method: The researchers administered two questionnaires. These were Rousseau’s Psychological Contract Inventory (2000 and the Human Resource Practices Scale of Geringer, Colette and Milliman (2002. The researchers conducted the study with 936 knowledge workers at an iron ore mining company in South Africa. They achieved a 32% response rate. Main findings: The findings showed that most participants have relational contracts with the organisation. Another 22% have balanced contracts, 8% have transitional contracts whilst only 1% have transactional contracts. The study suggests that there are relationships between these psychological contracts and specific human resource practices. The study found that training and development was the most important human resource practice for developing relational and balanced contracts. Employees thought that they contributed more than their employer did to the relationship. The researchers developed a model to illustrate the influence of the various human resource practices on
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van der Linden, Michelle; Meeuwis, Kim; van Hees, Colette; van Dorst, Eleonora; Bulten, Johan; Bosse, Tjalling; IntHout, Joanna; Boll, Dorry; Slangen, Brigitte; van Seters, Manon; van Beurden, Marc; van Poelgeest, Mariëtte; de Hullu, Joanne
2017-09-06
assessed by evaluation of adverse events and tolerability of treatment. To evaluate the immunological response, various immunological markers will be tested on biopsy specimens taken before, during, and after treatment. Quality of life will be assessed with three questionnaires taken before, during, and after treatment. First results are expected in the summer of 2018. ClinicalTrials.gov NCT02385188; https://clinicaltrials.gov/ct2/show/NCT02385188 (Archived by WebCite at http://www.webcitation.org/6sXygHuhP). ©Michelle van der Linden, Kim Meeuwis, Colette van Hees, Eleonora van Dorst, Johan Bulten, Tjalling Bosse, Joanna IntHout, Dorry Boll, Brigitte Slangen, Manon van Seters, Marc van Beurden, Mariëtte van Poelgeest, Joanne de Hullu. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 06.09.2017.
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Francois, Baptiste; Hingray, Benoit; Creutin, Jean-Dominique; Raynaud, Damien; Borga, Marco; Vautard, Robert
2015-04-01
over a long time period while past studies, to our knowledge, have used less than 10 year time period. References: Vautard, R., Thais, F., Tobin, I., Bréon, F.-M., de Lavergne, J.-G.D., Colette, A., Yiou, P., and Ruti, P.M. (2014). Regional climate model simulations indicate limited climatic impacts by operational and planned European wind farms. Nat. Commun. 5, 3196. Haylock, M.R., Hofstra, N., Tank, A.M.G.K., Klok, E.J., Jones, P.D., New, M., 2008. A European daily high-resolution gridded data set of surface temperature and precipitation for 1950-2006. J. Geophys. Res.-Atmos. 113. doi:10.1029/2008JD010201 GRDC (Global Runoff Data Center), 1999. Long-term mean monthly discharges of selected GRDC stations, Global Runoff Data Centre, Koblenz, Germany.
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Dancy-Scott, Nicole; Dutcher, Gale A; Keselman, Alla; Hochstein, Colette; Copty, Christina; Ben-Senia, Diane; Rajan, Sampada; Asencio, Maria Guadalupe; Choi, Jason Jongwon
2018-05-04
"men who have sex with men" and "MSM" were rarely used until 1994; subsequently, use of these terms increased through 2014. The term "sex worker" steadily increased in frequency throughout conference years, whereas the term "prostitute" decreased over time. The results of this study highlight changes in HIV terminology use over 25 years, including the addition, disappearance, and changing use of terms that reflect advances in HIV research and medical practice and destigmatization of the disease. Coupled with findings from related quantitative research, HIV-related terminology recommendations based on results of this study are included. Adoption of these recommendations will further efforts to use less stigmatizing language and facilitate effective communication between health professionals and people affected by HIV. ©Nicole Dancy-Scott, Gale A Dutcher, Alla Keselman, Colette Hochstein, Christina Copty, Diane Ben-Senia, Sampada Rajan, Maria Guadalupe Asencio, Jason Jongwon Choi. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 04.05.2018.
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Lakshmi Planum, Venus: Assessment of models using observations from geological mapping
Ivanov, M. A.; Head, J. W.
2008-09-01
(small volcanoes), embay the previous units and occur outside Lakshmi. (5) Pitted and grooved material (pgm) displays small pits and is cut by broad and shallow groove; it occurs inside Lakshmi in association with mountain ranges. (6) Lower unit of regional plains (rp1) has a smooth surface, is cut by wrinkle ridges; this most widespread unit occurs inside and outside of Lakshmi Planum. (7) Upper unit of regional plains (rp2) is also deformed by wrinkle ridges but has lobate boundaries and higher radar albedo than rp1; occurs both inside and outside Lakshmi. (8) Lobate plains (pl) is characterized by lobate flows that embay the most tectonic structures including wrinkle ridges; form fluctuses outside Lakshmi and surround Colette and Sacajawea Paterae inside the plateau. (9) Smooth plains (ps) have uniform and low radar albedo, embay wrinkle ridges; largest occurrence in southern portion of Lakshmi. (10) Impact craters (c) and (11) crater outflow deposits (cf); peppered throughout without preferential concentrations. Structures: Extensional structures. In places, fractures and graben form belts (groove belts, gb) that extend for hundreds of kilometers mostly within the southern regional slope of Lakshmi where they cut pdl and pr and are embayed by psh and rp1. Contractional structures. Wrinkle ridges mildly deform psh and regional plains; broader and more linear ridges dominate ridged plains (pr). The most important occurrences of contractional structures are mountain belts (unit mt) that surround the interior of Lakshmi and consist of densely spaced ridges 5-15 km wide, tens of km long. Regional plains usually embay the ridges. Sequence of major events during evolution of Lakshmi Planum: Various plains units heavily embay fragments of tessera in all localities inside and outside Lakshmi. The consistent relationships of embayment and the complex and unique surface deformational pattern suggest that tessera represents the oldest material. Tessera distribution patterns
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Institute of Scientific and Technical Information of China (English)
周少英
2015-01-01
Objective To evaluate the application of 18F-FDG PET/CT in assessing hilary cholangiocarcinoma before the surgery.Methods Retrospective analysis of preoperative assessment information of 45 cases of hepatic bile duct carcinoma in patients with portal vein 18F-FDG PET/CT were conducted,application of 18F-FDG PET/CT in judging Bismuth-Colette type, tumor location,lymph node metastasis,distant metastasis and respectable value evaluation were summed .Results (1)PET/CT examination showed that Bismuth -Corlette classification results of 37 cases were consistent with surgical pathology results ,the ac-curacy was 82.22%;(2)PET/CT examination in the diagnosis of lymph node metastasis on the sensitivity ,accuracy,specificity were 77.78%,83.33% and 80.00%,PET/CT examination in the diagnosis of distant metastases in sensitivity ,accuracy,speci-ficity were 55.56%,92.59% and 77.78%;(3)preoperative PET /CT examination evaluation for resectable cases was 34 cases, that of intraoperative evaluation was 29 cases;PET/CT preoperative examination evaluation for unresectable cases was 11 cases, that of intraoperative evaluation was 2 cases,there had no statistical difference(chi-square =0.50,P >0.50).Conclusion 18F-FDG PET/CT has a high value in the preoperative evaluation of hilary cholangiocarcinoma ,lymph node metastasis and distant me-tastasis,it can serve as an important means of evaluation for tumor resectablity .%目的：评价以18F 标记的脱氧葡萄糖（FDG）为示踪剂的正电子发射断层成像在肝门部胆管癌术前评估中的应用价值。方法回顾性分析45例肝门部胆管癌患者的18F－FDG PET／CT 术前评估资料，总结18F－FDG PET／CT在判断 Bismuth－Corlette 分型、肿瘤部位、淋巴结转移、远处转移以及可切除评价中的应用价值。结果①PET／CT 检查中共有37例患者的 Bismuth－Corlette 分型结果与手术病理结果一致，准确率为82．22％；②PET／CT
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Directory of Open Access Journals (Sweden)
Jennie Kelson
2008-03-01
Full Text Available Objective ‐ To compare journal usage between an acute National Health Service (NHS Trust and a specialist NHS Trust located in North West England to provide some evidence as to how well the National Core Content Collection (provided by ProQuest meets the needs of staff in these settings.Design ‐ Comparative studySetting ‐ An acute NHS Trust, comprising four hospital sites, and a cancer specialist NHS Trust based on a single site. Both Trusts are located in North West England. The cancer specialist NHS Trust is a teaching hospital with undergraduate nurses, medical students, and student radiographers. This Trust is also closely associated with an adjoining cancer research institute. The acute NHS Trust has a large number of healthcare staff in training and was not described as a teaching hospital.Subjects ‐ Staff of the respective NHS Trusts. The staff numbers for each organisation were not provided.Methods ‐ COUNTER usage statistics of online journals, obtained from publisher administration tools, were collected for one year covering the period 1 December 2005 to 30 November 2006. Where available, the number of photocopies made from print journals during the same period by library users for their own use was also included. All full‐text downloads of journal articles were counted as part of this study, hence the possibility of double counting if a single article was requested in both HTML and PDF versions. Details of free or open access articles accessed without the need for a username and password were not included in the study. To encourage use of the electronic journals, library services at both Trusts implemented a number of initiatives to maximize publicity. These included direct e‐mails to staff, posters, and presentations to staff. Athens registration, required for access to the electronic journal collections, was promoted as part of the induction process for new library users. Staff members were encouraged to apply for the electronic table of contents alert for journals in their area of specialty. An A‐Z list of journals was accessible via the Trusts’ intranet and internet sites, and direct links to electronic journals were added to the NHS Dialog/Datastar databases and on PubMed.Main results ‐ The libraries at both Trusts in the study provide the majority of their journals in electronic‐only format. In addition to the National Core Content titles, the cancer specialist Trust provides access to an additional five journal collections: Science Direct Health Sciences, Blackwell Synergy Medical and Nursing collection, five journals selected from Nature Publishing Group, selected society journals via HighWire Press and Oxford University Press titles. Staff members of the acute Trust have access to an additional three journal collections: Science Direct Health Sciences, the BMJ Publishing Group (BMJPG collection and 16 LWW titles via Ovid. During the study period, a total of 93,376 articles were downloaded or copied. Of these, 47,079 articles were downloaded or copied by staff of the cancer specialist NHS Trust and 46,297 articles were downloaded or copied by staff of the acute NHS Trust. The usage of each of the journal collections during the study period for each Trust is shown in the table below with the most used resource shown in bold. (See article for table General information regarding some of the commonly used journal titles by staff of each Trust was included in the commentary, but levels of use were not enumerated. Staff of the cancer specialist NHS Trust favoured cancer‐related titles, whilst staff of the acute NHS Trust accessed journal titles over a greater range of subject areas. Details of the top titles accessed from the National Core Content collection were not provided for either Trust. A possible reason given for the lower usage level of the National Core Content collection by the cancer specialist NHS Trust compared to the acute NHS Trust was the presence of embargoes on many cancer‐related titles within the National Core Content collection. Information about training offered to staff, their level of access to computer facilities,or familiarity with accessing electronic journal collections was not provided.Conclusion ‐ Staff of both Trusts in the study recorded a high level of journal use, with a total of 93,376 articles downloaded or photocopied during the study period. There was a marked difference in the usage patterns of the National Core Content journals between the two Trusts studied with the acute NHS Trust showing a higher proportion of usage (29.9%compared with the cancer specialist Trust(4.5%. Staff members of the acute NHS Trust accessed a greater range of subject areas, while staff those at the cancer specialist NHS Trust favoured cancer related titles.The results indicated that the National Core Content collection did not meet the information needs of the specialist cancer Trust as well as it met the needs of the more generalist acute Trust. The National Core Content collection appears insufficient to meet the diverse information needs of all NHS staff. Local purchasing of journals, in addition to national level provision, is therefore required to ensure that the needs of local specialties are adequately supported.
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Strada, Susanna; de Noblet-Ducoudré, Nathalie; Perrin, Mathieu; Stefanon, Marc
2016-04-01
-atmosphere models to LULCCs. RCP scenarios showing the largest impact on surface fluxes and carbon-water soil storage will be selected to force a coupled land-atmosphere model. Coupled land-atmosphere simulations will allow to account for atmospheric feedbacks in the assessment of the sensitivity of land-atmosphere models to LULCCs. In addition, this study aims to push further scenario development to build compelling LULCC scenarios. If the assessment of LULCC scenarios through numerical modelling may provide land planners with an established scientific basis to draw future land use policy, LULCC scenarios should depict realistic as well as extreme modifications at scales at which changes in landscapes are actually shaped. References de Noblet-Ducoudré, N., Boisier, J.-P., Pitman, A., Bonan, G. B., Brovkin, V., Cruz, F., Delire, C., Gayler, V., Van den Hurk, B. J. J. M., Lawrence, P. J., Van Der Molen, M. K., Müller, C., Reick, C. H. , Strengers, B. J., and Voldoire, A.: Determining robust impacts of land-use-induced land cover changes on surface climate over North America and Eurasia: results from the first set of LUCID experiments, J. Clim., 25, 3261‒3281, 2012. Jacob, D.,Petersen, J., Eggert, B., Alias, A., Christensen, O. B., Bouwer, L., Braun, A., Colette, A., Déqué, M., Georgievski, G., Georgopoulou, E., Gobiet, A., Menut, L., Nikulin, G., Haensler, A., Hempelmann, N., Jones, C., Keuler, K., Kovats, S., Kröner, N., Kotlarski, S., Kriegsmann, A., Martin, E., Meijgaard, E., Moseley, C., Pfeifer, S., Preuschmann, S., Radermacher, C., Radtke, K., Rechid, D., Rounsevell, M.; Samuelsson, P., Somot, S., Soussana, J.-F., Teichmann, C., Valentini, R., Vautard, R., Weber, B. and Yiou, P.: EURO-CORDEX: new high-resolution climate change projections for European impact research, Reg. Environ. Change, Springer Berlin Heidelberg, 2013, 1-16. Mahmood, R., Pielke, R. A., Hubbard, K. G., Niyogi, D., Dirmeyer, P. A., McAlpine, C., Carleton, A. M., Hale, R., Gameda, S., Beltr
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6th International Symposium on Molecular Allergology (ISMA
Directory of Open Access Journals (Sweden)
Christiane Hilger
2016-10-01
, Marianne Van Hage P18 Specificity of non-specific lipid transfer proteins and influence of the ligands on their three-dimensional structure Pawel Dubiela, Piotr Humeniuk, Sabine Pfeifer, Merima Bublin, Tomasz Borowski, Karin Hoffmann-Sommergruber P19 Real-time PCR analysis of Pru av 1 and Pru av 3 allergens Martie C.M. Verschuren, Shanna Bastiaan-Net, Defien Depoortere, Kay Foetisch, Stephan Scheurer, Harry J Wichers, Theo Noij P20 Specificity of anti-Pru av 1 antibodies for the detection of Pru av 1 isoallergens Martie C.M. Verschuren, Shanna Bastiaan-Net, Nikki M.E. Van Uden, Karel Vandenberghe, Kay Foetisch, Stephan Scheurer, Harry J. Wichers H.J., Theo H.M. Noij P21 Enhancing recombinant production yield of Bet v 1 through codon usage harmonization Anargyros Roulias, Maria Alejandra Parigiani, Heidi Hofer, Claudia Asam, Christof Ebner, Fátima Ferreira P22 Structural and dynamic insights into the world of PR-10 allergens Linda Ahammer, Sarina Grutsch, Martin Tollinger Poster Session 3: Allergen molecules: identification, characterization, structure and function P23 Purification of polcalcin from different pollen allergenic sources by antibody-affinity chromatography Raquel Moya, Mª Angeles López-Matas, Raquel Reyes, Jerónimo Carnés P24 Variations of wheat allergens in cultivars measured through a targeted quantitative mass spectrometry approach Colette Larré, Hélène Rogniaux, Roberta Lupi, Sandra Denery-Papini P25 Art v 1, Amb a 4 and Par h 1 defensin-like proteins share similar structural features but distinct immunological and allergenic properties Isabel Maria Pablos, Stephanie Eichhorn, Yoan Machado, Peter Briza, Christof Ebner, Jung-Won Park, Alain Didierlaurent, Naveen Arora, Stefan Vieths, Gabriele Gadermaier, Fatima Ferreira P26 Homogeneity or diversity of IgE-binding proteins in wheat dependant exercise induced anaphylaxis? Sandra Denery-Papini, Charlene Tanaka, Florence Pineau, Roberta Lupi, Martine Drouet, Etienne Beaudouin, Martine Morisset, Susan
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XXXI LIAC Meeting on Vascular Research - Proceedings
Directory of Open Access Journals (Sweden)
L. Monteiro Rodrigues et al.
2015-12-01
Full Text Available LIAC MEETING ON VASCULAR RESEARCH 9 a 12 September | 9 a 12 Setembro Lisbon U. Lusofona's | Lisboa - Universidade Lusófona Scientific Commitee /Comissão Científica Luís Monteiro Rodrigues Philippe Charpiot, Brigida Bochicchio Alain-Pierre Gadeau Jacques Bonnet Julia Bujan Colette Lacabanne Fulvia Ortolani Organizing Commitee /Comissão Organizadora Luis Monteiro Rodrigues, CBIOS - ULHT Ana Sofia Fernandes, CBIOS - ULHT Catarina Pinto Reis, CBIOS - ULHT Henrique Silva, CBIOS - ULHT Hugo Ferreira, IBEB - FCUL Escola de Ciências e Tecnologias da Saúde (ECTS da U. Lusófona de Humanidades e Tecnologias ALIES – Associação Lusófona para o Desenvolvimento do Ensino e Investigação das Ciências da Saúde CBIOS – Centro de Investigação em Biociências e Tecnologias da Saúde Program /Programa 9 September | 9 de Setembro Open Session | Sessão de abertura António Tamburro Conference Lisboa's Wine & Cheese battle 10 September | 10 de Setembro 1st Session |Sessão 1 Molecular and Supramolecular Structure | Estrutura Molecular e Supramolecular Charmain | Moderador - Alain Pierre Gadeau Keynote lecture 1 | 1ª Conferência Keynote Speaker | Prelector Sylvie Ricard-Blum Free Comunications | Comunicações livres Speakers | Prelectores Brigida Bochicchio Vicenta Llorente-Cortés Zeinab El Dirani J Leal Monedero Keynote lecture 2 | 2ª Conferência Keynote Speaker | Prelector Valerie Samouillan Program /Programa (cont. 2st Session |Sessão 2 Cell Biology and Signaling | Biologia Celular e Sinalização Charmain | Moderador - Michel Spina Keynote lecture 3 | 3ª Conferência Keynote Speaker | Prelector Vicente Andrés Free Comunications | Comunicações livres Speakers | Prelectores Alain Gadeau Cristina Sena Filipe Paula Pascal Maurice 11 September | 11 de Setembro 3st Session |Sessão 3 Biomaterials and Tissue Engineering | Biomateriais e Engenharia de Tecidos Charmain | Moderador - Brigida Bochicchio Keynote lecture 4 | 4ª Confer