Lesion detection in ultra-wide field retinal images for diabetic retinopathy diagnosis

Science.gov (United States)

Levenkova, Anastasia; Sowmya, Arcot; Kalloniatis, Michael; Ly, Angelica; Ho, Arthur

2018-02-01

Diabetic retinopathy (DR) leads to irreversible vision loss. Diagnosis and staging of DR is usually based on the presence, number, location and type of retinal lesions. Ultra-wide field (UWF) digital scanning laser technology provides an opportunity for computer-aided DR lesion detection. High-resolution UWF images (3078×2702 pixels) may allow detection of more clinically relevant retinopathy in comparison with conventional retinal images as UWF imaging covers a 200° retinal area, versus 45° by conventional cameras. Current approaches to DR diagnosis that analyze 7-field Early Treatment Diabetic Retinopathy Study (ETDRS) retinal images provide similar results to UWF imaging. However, in 40% of cases, more retinopathy was found outside the 7- field ETDRS fields by UWF and in 10% of cases, retinopathy was reclassified as more severe. The reason is that UWF images examine both the central retina and more peripheral regions. We propose an algorithm for automatic detection and classification of DR lesions such as cotton wool spots, exudates, microaneurysms and haemorrhages in UWF images. The algorithm uses convolutional neural network (CNN) as a feature extractor and classifies the feature vectors extracted from colour-composite UWF images using a support vector machine (SVM). The main contribution includes detection of four types of DR lesions in the peripheral retina for diagnostic purposes. The evaluation dataset contains 146 UWF images. The proposed method for detection of DR lesion subtypes in UWF images using two scenarios for transfer learning achieved AUC ≈ 80%. Data was split at the patient level to validate the proposed algorithm.

PSF Estimation of Space-Variant Ultra-Wide Field of View Imaging Systems

Directory of Open Access Journals (Sweden)

Petr Janout

2017-02-01

Full Text Available Ultra-wide-field of view (UWFOV imaging systems are affected by various aberrations, most of which are highly angle-dependent. A description of UWFOV imaging systems, such as microscopy optics, security camera systems and other special space-variant imaging systems, is a difficult task that can be achieved by estimating the Point Spread Function (PSF of the system. This paper proposes a novel method for modeling the space-variant PSF of an imaging system using the Zernike polynomials wavefront description. The PSF estimation algorithm is based on obtaining field-dependent expansion coefficients of the Zernike polynomials by fitting real image data of the analyzed imaging system using an iterative approach in an initial estimate of the fitting parameters to ensure convergence robustness. The method is promising as an alternative to the standard approach based on Shack–Hartmann interferometry, since the estimate of the aberration coefficients is processed directly in the image plane. This approach is tested on simulated and laboratory-acquired image data that generally show good agreement. The resulting data are compared with the results of other modeling methods. The proposed PSF estimation method provides around 5% accuracy of the optical system model.

Wide-field time-resolved luminescence imaging and spectroscopy to decipher obliterated documents in forensic science

Science.gov (United States)

Suzuki, Mototsugu; Akiba, Norimitsu; Kurosawa, Kenji; Kuroki, Kenro; Akao, Yoshinori; Higashikawa, Yoshiyasu

2016-01-01

We applied a wide-field time-resolved luminescence (TRL) method with a pulsed laser and a gated intensified charge coupled device (ICCD) for deciphering obliterated documents for use in forensic science. The TRL method can nondestructively measure the dynamics of luminescence, including fluorescence and phosphorescence lifetimes, which prove to be useful parameters for image detection. First, we measured the TRL spectra of four brands of black porous-tip pen inks on paper to estimate their luminescence lifetimes. Next, we acquired the TRL images of 12 obliterated documents at various delay times and gate times of the ICCD. The obliterated contents were revealed in the TRL images because of the difference in the luminescence lifetimes of the inks. This method requires no pretreatment, is nondestructive, and has the advantage of wide-field imaging, which makes it is easy to control the gate timing. This demonstration proves that TRL imaging and spectroscopy are powerful tools for forensic document examination.

The Wide Field Imager instrument for Athena

Science.gov (United States)

Meidinger, Norbert; Barbera, Marco; Emberger, Valentin; Fürmetz, Maria; Manhart, Markus; Müller-Seidlitz, Johannes; Nandra, Kirpal; Plattner, Markus; Rau, Arne; Treberspurg, Wolfgang

2017-08-01

ESA's next large X-ray mission ATHENA is designed to address the Cosmic Vision science theme 'The Hot and Energetic Universe'. It will provide answers to the two key astrophysical questions how does ordinary matter assemble into the large-scale structures we see today and how do black holes grow and shape the Universe. The ATHENA spacecraft will be equipped with two focal plane cameras, a Wide Field Imager (WFI) and an X-ray Integral Field Unit (X-IFU). The WFI instrument is optimized for state-of-the-art resolution spectroscopy over a large field of view of 40 amin x 40 amin and high count rates up to and beyond 1 Crab source intensity. The cryogenic X-IFU camera is designed for high-spectral resolution imaging. Both cameras share alternately a mirror system based on silicon pore optics with a focal length of 12 m and large effective area of about 2 m2 at an energy of 1 keV. Although the mission is still in phase A, i.e. studying the feasibility and developing the necessary technology, the definition and development of the instrumentation made already significant progress. The herein described WFI focal plane camera covers the energy band from 0.2 keV to 15 keV with 450 μm thick fully depleted back-illuminated silicon active pixel sensors of DEPFET type. The spatial resolution will be provided by one million pixels, each with a size of 130 μm x 130 μm. The time resolution requirement for the WFI large detector array is 5 ms and for the WFI fast detector 80 μs. The large effective area of the mirror system will be completed by a high quantum efficiency above 90% for medium and higher energies. The status of the various WFI subsystems to achieve this performance will be described and recent changes will be explained here.

Intact skull chronic windows for mesoscopic wide-field imaging in awake mice

Science.gov (United States)

Silasi, Gergely; Xiao, Dongsheng; Vanni, Matthieu P.; Chen, Andrew C. N.; Murphy, Timothy H.

2016-01-01

Background Craniotomy-based window implants are commonly used for microscopic imaging, in head-fixed rodents, however their field of view is typically small and incompatible with mesoscopic functional mapping of cortex. New Method We describe a reproducible and simple procedure for chronic through-bone wide-field imaging in awake head-fixed mice providing stable optical access for chronic imaging over large areas of the cortex for months. Results The preparation is produced by applying clear-drying dental cement to the intact mouse skull, followed by a glass coverslip to create a partially transparent imaging surface. Surgery time takes about 30 minutes. A single set-screw provides a stable means of attachment for mesoscale assessment without obscuring the cortical field of view. Comparison with Existing Methods We demonstrate the utility of this method by showing seed-pixel functional connectivity maps generated from spontaneous cortical activity of GCAMP6 signals in both awake and anesthetized mice. Conclusions We propose that the intact skull preparation described here may be used for most longitudinal studies that do not require micron scale resolution and where cortical neural or vascular signals are recorded with intrinsic sensors. PMID:27102043

Wide-field high-performance geosynchronous imaging

International Nuclear Information System (INIS)

Wood, H. John; Jenstrom, Del; Wilson, Mark; Hinkal, Sanford; Kirchman, Frank

1998-01-01

The NASA Mission to Planet Earth (MTPE) Program and the National Oceanographic and Atmospheric Administration (NOAA) are sponsoring the Advanced Geosynchronous Studies (AGS) to develop technologies and system concepts for Earth observation from geosynchronous orbit. This series of studies is intended to benefit both MTPE science and the NOAA GOES Program. Within the AGS program, advanced imager trade studies have investigated two candidate concepts for near-term advanced geosynchronous imagers. One concept uses a scan mirror to direct the line of sight from a 3-axis stabilized platform. Another eliminates the need for a scan mirror by using an agile spacecraft bus to scan the entire instrument. The purpose of this paper is to discuss the optical design trades and system issues encountered in evaluating the two scanning approaches. The imager design started with a look at first principles: what is the most efficient way to image the Earth in those numerous spectral bands of interest to MTPE scientists and NOAA weather forecasters. Optical design trades included rotating filter wheels and dispersive grating instruments. The design converged on a bandpass filter instrument using four focal planes to cover the spectral range 0.45 to 13.0 micrometers. The first imager design uses a small agile spacecraft supporting an afocal optical telescope. Dichroic beamsplitters feed refractive objectives to four focal planes. The detectors are a series of long linear and rectangular arrays which are scanned in a raster fashion over the 17 degree Earth image. The use of the spacecraft attitude control system to raster the imager field-of-view (FOV) back and forth over the Earth eliminates the need for a scan mirror. However, the price paid is significant energy and time required to reverse the spacecraft slew motions at the end of each scan line. Hence, it is desired to minimize the number of scan lines needed to cover the full Earth disk. This desire, coupled with the ground

Automatic detection of diabetic retinopathy features in ultra-wide field retinal images

Science.gov (United States)

Levenkova, Anastasia; Sowmya, Arcot; Kalloniatis, Michael; Ly, Angelica; Ho, Arthur

2017-03-01

Diabetic retinopathy (DR) is a major cause of irreversible vision loss. DR screening relies on retinal clinical signs (features). Opportunities for computer-aided DR feature detection have emerged with the development of Ultra-WideField (UWF) digital scanning laser technology. UWF imaging covers 82% greater retinal area (200°), against 45° in conventional cameras3 , allowing more clinically relevant retinopathy to be detected4 . UWF images also provide a high resolution of 3078 x 2702 pixels. Currently DR screening uses 7 overlapping conventional fundus images, and the UWF images provide similar results1,4. However, in 40% of cases, more retinopathy was found outside the 7-field ETDRS) fields by UWF and in 10% of cases, retinopathy was reclassified as more severe4 . This is because UWF imaging allows examination of both the central retina and more peripheral regions, with the latter implicated in DR6 . We have developed an algorithm for automatic recognition of DR features, including bright (cotton wool spots and exudates) and dark lesions (microaneurysms and blot, dot and flame haemorrhages) in UWF images. The algorithm extracts features from grayscale (green "red-free" laser light) and colour-composite UWF images, including intensity, Histogram-of-Gradient and Local binary patterns. Pixel-based classification is performed with three different classifiers. The main contribution is the automatic detection of DR features in the peripheral retina. The method is evaluated by leave-one-out cross-validation on 25 UWF retinal images with 167 bright lesions, and 61 other images with 1089 dark lesions. The SVM classifier performs best with AUC of 94.4% / 95.31% for bright / dark lesions.

Wide-field spectrally resolved quantitative fluorescence imaging system: toward neurosurgical guidance in glioma resection

Science.gov (United States)

Xie, Yijing; Thom, Maria; Ebner, Michael; Wykes, Victoria; Desjardins, Adrien; Miserocchi, Anna; Ourselin, Sebastien; McEvoy, Andrew W.; Vercauteren, Tom

2017-11-01

In high-grade glioma surgery, tumor resection is often guided by intraoperative fluorescence imaging. 5-aminolevulinic acid-induced protoporphyrin IX (PpIX) provides fluorescent contrast between normal brain tissue and glioma tissue, thus achieving improved tumor delineation and prolonged patient survival compared with conventional white-light-guided resection. However, commercially available fluorescence imaging systems rely solely on visual assessment of fluorescence patterns by the surgeon, which makes the resection more subjective than necessary. We developed a wide-field spectrally resolved fluorescence imaging system utilizing a Generation II scientific CMOS camera and an improved computational model for the precise reconstruction of the PpIX concentration map. In our model, the tissue's optical properties and illumination geometry, which distort the fluorescent emission spectra, are considered. We demonstrate that the CMOS-based system can detect low PpIX concentration at short camera exposure times, while providing high-pixel resolution wide-field images. We show that total variation regularization improves the contrast-to-noise ratio of the reconstructed quantitative concentration map by approximately twofold. Quantitative comparison between the estimated PpIX concentration and tumor histopathology was also investigated to further evaluate the system.

Rapid wide-field Mueller matrix polarimetry imaging based on four photoelastic modulators with no moving parts.

Science.gov (United States)

Alali, Sanaz; Gribble, Adam; Vitkin, I Alex

2016-03-01

A new polarimetry method is demonstrated to image the entire Mueller matrix of a turbid sample using four photoelastic modulators (PEMs) and a charge coupled device (CCD) camera, with no moving parts. Accurate wide-field imaging is enabled with a field-programmable gate array (FPGA) optical gating technique and an evolutionary algorithm (EA) that optimizes imaging times. This technique accurately and rapidly measured the Mueller matrices of air, polarization elements, and turbid phantoms. The system should prove advantageous for Mueller matrix analysis of turbid samples (e.g., biological tissues) over large fields of view, in less than a second.

UVUDF: Ultraviolet Imaging of the Hubble Ultra Deep Field with Wide-Field Camera 3

Science.gov (United States)

Teplitz, Harry I.; Rafelski, Marc; Kurczynski, Peter; Bond, Nicholas A.; Grogin, Norman; Koekemoer, Anton M.; Atek, Hakim; Brown, Thomas M.; Coe, Dan; Colbert, James W.; Ferguson, Henry C.; Finkelstein, Steven L.; Gardner, Jonathan P.; Gawiser, Eric; Giavalisco, Mauro; Gronwall, Caryl; Hanish, Daniel J.; Lee, Kyoung-Soo; de Mello, Duilia F.; Ravindranath, Swara; Ryan, Russell E.; Siana, Brian D.; Scarlata, Claudia; Soto, Emmaris; Voyer, Elysse N.; Wolfe, Arthur M.

2013-12-01

We present an overview of a 90 orbit Hubble Space Telescope treasury program to obtain near-ultraviolet imaging of the Hubble Ultra Deep Field using the Wide Field Camera 3 UVIS detector with the F225W, F275W, and F336W filters. This survey is designed to: (1) investigate the episode of peak star formation activity in galaxies at 1 dropouts at redshifts 1.7, 2.1, and 2.7 is largely consistent with the number predicted by published luminosity functions. We also confirm that the image mosaics have sufficient sensitivity and resolution to support the analysis of the evolution of star-forming clumps, reaching 28-29th magnitude depth at 5σ in a 0.''2 radius aperture depending on filter and observing epoch. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. These observations are #12534.

Wide-Field Vibrational Phase Contrast Imaging Based on Coherent Anti-Stokes Raman Scattering Holography

International Nuclear Information System (INIS)

Lv Yong-Gang; Ji Zi-Heng; Dong Da-Shan; Gong Qi-Huang; Shi Ke-Bin

2015-01-01

We propose and implement a wide-field vibrational phase contrast detection to obtain imaging of imaginary components of third-order nonlinear susceptibility in a coherent anti-Stokes Raman scattering (CARS) microscope with full suppression of the non-resonant background. This technique is based on the unique ability of recovering the phase of the generated CARS signal based on holographic recording. By capturing the phase distributions of the generated CARS field from the sample and from the environment under resonant illumination, we demonstrate the retrieval of imaginary components in the CARS microscope and achieve background free coherent Raman imaging. (paper)

WISH: Wide-field Imaging Durvayor for High-redshift

Science.gov (United States)

Yamada, Toru

2015-08-01

We introduce the concept and current status of WISH project and discuss the science cases. WISH is a proposed space science mission for JAXA, which is dedicated for the deep and wide-field near-infrared imaging surveys. The mission contains the 1.5m cooled telescope as well as the imager with the FoV of ~850 square arcmin. The main goal of WISH is to detect and study galaxies at z=8-15 in the earliest history of structure formation in the universe. The key feature is to conduct WISH Ultra Deep Survey, which images in total of 100 square degrees in 6 broad-band filters at 0.9-4.5 micron down to 28AB magnitude. While more than 10^5 galaxies at z=8-9, 10^4 galaxies at z=11-12 will be detected, WISH-UDS is designed to constrain UV luminosity function at z=15. Depending on the models of the earliest evolution history, 1-1000 galaxies at z~15 (~100 galaxies for the moderate cases) will be detected. The UV spectral properties as well as the clustering properties of galaxies at z=8-15 can be studied as well; UV slope can be measured up to z=15, and the stellar and dark-matter-halo masses can be obtained up to z=9. WISH UDS can provide excellent opportunities for studying SNe at high redshift. Up to ~7000 type Ia SNe at z>1 can be detected and the distance modulus can be constrained with the precision of 0.9-1.5% at z>1.5. More than 100 Super Luminous SNe at z>6, and 10 SLSN at z>10 can also be detected, which allow us to study the earliest history of massive star formation in the universe. WISH imaging surveys as well as WISHSpec, which is an optional parallel-operation simple IFU spectrograph, also provide unique opportunities in various astronomical fields. WISH mission proposal was submitted to JAXA in February 2015 for the first down selection of JAXA Large Strategic Science Mission targeting the launch date in 2020-22. International collaborations including SAO (G.Fazio et al.), LAM (D. Burgarella et al.) and Canada (M.Sawicki et al.) are also actively coordinated.

Dual-conjugate adaptive optics for wide-field high-resolution retinal imaging.

Science.gov (United States)

Thaung, Jörgen; Knutsson, Per; Popovic, Zoran; Owner-Petersen, Mette

2009-03-16

We present analysis and preliminary laboratory testing of a real-time dual-conjugate adaptive optics (DCAO) instrument for ophthalmology that will enable wide-field high resolution imaging of the retina in vivo. The setup comprises five retinal guide stars (GS) and two deformable mirrors (DM), one conjugate to the pupil and one conjugate to a plane close to the retina. The DCAO instrument has a closed-loop wavefront sensing wavelength of 834 nm and an imaging wavelength of 575 nm. It incorporates an array of collimator lenses to spatially filter the light from all guide stars using one adjustable iris, and images the Hartmann patterns of multiple reference sources on a single detector. Zemax simulations were performed at 834 nm and 575 nm with the Navarro 99 and the Liou- Brennan eye models. Two correction alternatives were evaluated; conventional single conjugate AO (SCAO, using one GS and a pupil DM) and DCAO (using multiple GS and two DM). Zemax simulations at 575 nm based on the Navarro 99 eye model show that the diameter of the corrected field of view for diffraction-limited imaging (Strehl >or= 0.8) increases from 1.5 deg with SCAO to 6.5 deg using DCAO. The increase for the less stringent condition of a wavefront error of 1 rad or less (Strehl >or= 0.37) is from 3 deg with SCAO to approximately 7.4 deg using DCAO. Corresponding results for the Liou-Brennan eye model are 3.1 deg (SCAO) and 8.2 deg (DCAO) for Strehl >or= 0.8, and 4.8 deg (SCAO) and 9.6 deg (DCAO) for Strehl >or= 0.37. Potential gain in corrected field of view with DCAO is confirmed both by laboratory experiments on a model eye and by preliminary in vivo imaging of a human eye. (c) 2009 Optical Society of America

Imaging design of the wide field x-ray monitor onboard the HETE satellite

International Nuclear Information System (INIS)

Zand, J.J.M. In'T; Fenimore, E.E.; Kawai, N.; Yoshida, A.; Matsuoka, M.; Yamauchi, M.

1994-01-01

The High Energy Transient Experiment (HETE), to be launched in 1995, will study Gamma-Ray Bursts in an unprecendented wide wavelength range from Gamma- and X-ray to UV wavelengths. The X-ray range (2 to 25 keV) will be covered by 2 perpendicularly oriented 1-dimensional coded aperture cameras. These instruments cover a wide field of view of 2 sr and thus have a relatively large potential to locate GRBs to a fraction of a degree, which is an order of magnitude better than BATSE. The imaging design of these coded aperture cameras relates to the design of the coded apertures and the decoding algorithm. The aperture pattern is to a large extent determined by the high background in this wide field application and the low number of pattern elements (∼100) in each direction. The result is a random pattern with an open fraction of 33%. The onboard decoding algorithm is dedicated to the localization of a single point source

Wide Field-of-View Fluorescence Imaging with Optical-Quality Curved Microfluidic Chamber for Absolute Cell Counting

Directory of Open Access Journals (Sweden)

Mohiuddin Khan Shourav

2016-07-01

Full Text Available Field curvature and other aberrations are encountered inevitably when designing a compact fluorescence imaging system with a simple lens. Although multiple lens elements can be used to correct most such aberrations, doing so increases system cost and complexity. Herein, we propose a wide field-of-view (FOV fluorescence imaging method with an unconventional optical-quality curved sample chamber that corrects the field curvature caused by a simple lens. Our optics simulations and proof-of-concept experiments demonstrate that a curved substrate with lens-dependent curvature can reduce greatly the distortion in an image taken with a conventional planar detector. Following the validation study, we designed a curved sample chamber that can contain a known amount of sample volume and fabricated it at reasonable cost using plastic injection molding. At a magnification factor of approximately 0.6, the curved chamber provides a clear view of approximately 119 mm2, which is approximately two times larger than the aberration-free area of a planar chamber. Remarkably, a fluorescence image of microbeads in the curved chamber exhibits almost uniform intensity over the entire field even with a simple lens imaging system, whereas the distorted boundary region has much lower brightness than the central area in the planar chamber. The absolute count of white blood cells stained with a fluorescence dye was in good agreement with that obtained by a commercially available conventional microscopy system. Hence, a wide FOV imaging system with the proposed curved sample chamber would enable us to acquire an undistorted image of a large sample volume without requiring a time-consuming scanning process in point-of-care diagnostic applications.

Wide-field phase imaging for the endoscopic detection of dysplasia and early-stage esophageal cancer

Science.gov (United States)

Fitzpatrick, C. R. M.; Gordon, G. S. D.; Sawyer, T. W.; Wilkinson, T. D.; Bohndiek, S. E.

2018-02-01

Esophageal cancer has a 5-year survival rate below 20%, but can be curatively resected if it is detected early. At present, poor contrast for early lesions in white light imaging leads to a high miss rate in standard-of- care endoscopic surveillance. Early lesions in the esophagus, referred to as dysplasia, are characterized by an abundance of abnormal cells with enlarged nuclei. This tissue has a different refractive index profile to healthy tissue, which results in different light scattering properties and provides a source of endogenous contrast that can be exploited for advanced endoscopic imaging. For example, point measurements of such contrast can be made with scattering spectroscopy, while optical coherence tomography generates volumetric data. However, both require specialist interpretation for diagnostic decision making. We propose combining wide-field phase imaging with existing white light endoscopy in order to provide enhanced contrast for dysplasia and early-stage cancer in an image format that is familiar to endoscopists. Wide-field phase imaging in endoscopy can be achieved using coherent illumination combined with phase retrieval algorithms. Here, we present the design and simulation of a benchtop phase imaging system that is compatible with capsule endoscopy. We have undertaken preliminary optical modelling of the phase imaging setup, including aberration correction simulations and an investigation into distinguishing between different tissue phantom scattering coefficients. As our approach is based on phase retrieval rather than interferometry, it is feasible to realize a device with low-cost components for future clinical implementation.

Wide-Field Imaging Telescope-0 (WIT0) with automatic observing system

Science.gov (United States)

Ji, Tae-Geun; Byeon, Seoyeon; Lee, Hye-In; Park, Woojin; Lee, Sang-Yun; Hwang, Sungyong; Choi, Changsu; Gibson, Coyne Andrew; Kuehne, John W.; Prochaska, Travis; Marshall, Jennifer L.; Im, Myungshin; Pak, Soojong

2018-01-01

We introduce Wide-Field Imaging Telescope-0 (WIT0), with an automatic observing system. It is developed for monitoring the variabilities of many sources at a time, e.g. young stellar objects and active galactic nuclei. It can also find the locations of transient sources such as a supernova or gamma-ray bursts. In 2017 February, we installed the wide-field 10-inch telescope (Takahashi CCA-250) as a piggyback system on the 30-inch telescope at the McDonald Observatory in Texas, US. The 10-inch telescope has a 2.35 × 2.35 deg field-of-view with a 4k × 4k CCD Camera (FLI ML16803). To improve the observational efficiency of the system, we developed a new automatic observing software, KAOS30 (KHU Automatic Observing Software for McDonald 30-inch telescope), which was developed by Visual C++ on the basis of a windows operating system. The software consists of four control packages: the Telescope Control Package (TCP), the Data Acquisition Package (DAP), the Auto Focus Package (AFP), and the Script Mode Package (SMP). Since it also supports the instruments that are using the ASCOM driver, the additional hardware installations become quite simplified. We commissioned KAOS30 in 2017 August and are in the process of testing. Based on the WIT0 experiences, we will extend KAOS30 to control multiple telescopes in future projects.

TAURUS - a wide field imaging Fabry-Perot spectrometer

International Nuclear Information System (INIS)

Atherton, P.D.; Taylor, K.

1983-01-01

TAURUS, an imaging Fabry-Perot system developed by the Royal Greenwich Observatory and Imperial College London, is described. The imaging process is explained and the technique is compared with grating spectrographs. It is argued that TAURUS is superior for obtaining field information from extended emission line sources. (Auth.)

Wide-field fluorescent microscopy and fluorescent imaging flow cytometry on a cell-phone.

Science.gov (United States)

Zhu, Hongying; Ozcan, Aydogan

2013-04-11

Fluorescent microscopy and flow cytometry are widely used tools in biomedical research and clinical diagnosis. However these devices are in general relatively bulky and costly, making them less effective in the resource limited settings. To potentially address these limitations, we have recently demonstrated the integration of wide-field fluorescent microscopy and imaging flow cytometry tools on cell-phones using compact, light-weight, and cost-effective opto-fluidic attachments. In our flow cytometry design, fluorescently labeled cells are flushed through a microfluidic channel that is positioned above the existing cell-phone camera unit. Battery powered light-emitting diodes (LEDs) are butt-coupled to the side of this microfluidic chip, which effectively acts as a multi-mode slab waveguide, where the excitation light is guided to uniformly excite the fluorescent targets. The cell-phone camera records a time lapse movie of the fluorescent cells flowing through the microfluidic channel, where the digital frames of this movie are processed to count the number of the labeled cells within the target solution of interest. Using a similar opto-fluidic design, we can also image these fluorescently labeled cells in static mode by e.g. sandwiching the fluorescent particles between two glass slides and capturing their fluorescent images using the cell-phone camera, which can achieve a spatial resolution of e.g. - 10 μm over a very large field-of-view of - 81 mm(2). This cell-phone based fluorescent imaging flow cytometry and microscopy platform might be useful especially in resource limited settings, for e.g. counting of CD4+ T cells toward monitoring of HIV+ patients or for detection of water-borne parasites in drinking water.

Searching for transits in the Wide Field Camera Transit Survey with difference-imaging light curves

NARCIS (Netherlands)

Zendejas, Dominguez J.; Koppenhoefer, J.; Saglia, R.; Birkby, J.L.; Hodgkin, S.; Kovács, G.; Pinfield, D.; Sipocz, B.; Barrado, D.; Bender, R.; Burgo, del C.; Cappetta, M.; Martín, E.; Nefs, B.; Riffeser, A.; Steele, P.

2013-01-01

The Wide Field Camera Transit Survey is a pioneer program aiming at for searching extra-solar planets in the near-infrared. The images from the survey are processed by a data reduction pipeline, which uses aperture photometry to construct the light curves. We produce an alternative set of light

1-Million droplet array with wide-field fluorescence imaging for digital PCR.

Science.gov (United States)

Hatch, Andrew C; Fisher, Jeffrey S; Tovar, Armando R; Hsieh, Albert T; Lin, Robert; Pentoney, Stephen L; Yang, David L; Lee, Abraham P

2011-11-21

Digital droplet reactors are useful as chemical and biological containers to discretize reagents into picolitre or nanolitre volumes for analysis of single cells, organisms, or molecules. However, most DNA based assays require processing of samples on the order of tens of microlitres and contain as few as one to as many as millions of fragments to be detected. Presented in this work is a droplet microfluidic platform and fluorescence imaging setup designed to better meet the needs of the high-throughput and high-dynamic-range by integrating multiple high-throughput droplet processing schemes on the chip. The design is capable of generating over 1-million, monodisperse, 50 picolitre droplets in 2-7 minutes that then self-assemble into high density 3-dimensional sphere packing configurations in a large viewing chamber for visualization and analysis. This device then undergoes on-chip polymerase chain reaction (PCR) amplification and fluorescence detection to digitally quantify the sample's nucleic acid contents. Wide-field fluorescence images are captured using a low cost 21-megapixel digital camera and macro-lens with an 8-12 cm(2) field-of-view at 1× to 0.85× magnification, respectively. We demonstrate both end-point and real-time imaging ability to perform on-chip quantitative digital PCR analysis of the entire droplet array. Compared to previous work, this highly integrated design yields a 100-fold increase in the number of on-chip digitized reactors with simultaneous fluorescence imaging for digital PCR based assays.

THE SPITZER DEEP, WIDE-FIELD SURVEY

International Nuclear Information System (INIS)

Ashby, M. L. N.; Brodwin, M.; Stern, D.; Griffith, R.; Eisenhardt, P.; Gorjian, V.; Kozlowski, S.; Kochanek, C. S.; Bock, J. J.; Borys, C.; Brand, K.; Grogin, N. A.; Brown, M. J. I.; Cool, R.; Cooray, A.; Croft, S.; Dey, A.; Eisenstein, D.; Gonzalez, A. H.; Ivison, R. J.

2009-01-01

The Spitzer Deep, Wide-Field Survey (SDWFS) is a four-epoch infrared survey of 10 deg. 2 in the Booetes field of the NOAO Deep Wide-Field Survey using the IRAC instrument on the Spitzer Space Telescope. SDWFS, a Spitzer Cycle 4 Legacy project, occupies a unique position in the area-depth survey space defined by other Spitzer surveys. The four epochs that make up SDWFS permit-for the first time-the selection of infrared-variable and high proper motion objects over a wide field on timescales of years. Because of its large survey volume, SDWFS is sensitive to galaxies out to z ∼ 3 with relatively little impact from cosmic variance for all but the richest systems. The SDWFS data sets will thus be especially useful for characterizing galaxy evolution beyond z ∼ 1.5. This paper explains the SDWFS observing strategy and data processing, presents the SDWFS mosaics and source catalogs, and discusses some early scientific findings. The publicly released, full-depth catalogs contain 6.78, 5.23, 1.20, and 0.96 x 10 5 distinct sources detected to the average 5σ, 4''-diameter, aperture-corrected limits of 19.77, 18.83, 16.50, and 15.82 Vega mag at 3.6, 4.5, 5.8, and 8.0 μm, respectively. The SDWFS number counts and color-color distribution are consistent with other, earlier Spitzer surveys. At the 6 minute integration time of the SDWFS IRAC imaging, >50% of isolated Faint Images of the Radio Sky at Twenty cm radio sources and >80% of on-axis XBooetes sources are detected out to 8.0 μm. Finally, we present the four highest proper motion IRAC-selected sources identified from the multi-epoch imaging, two of which are likely field brown dwarfs of mid-T spectral class.

Ultra-wide-field angiography improves the detection and classification of diabetic retinopathy.

Science.gov (United States)

Wessel, Matthew M; Aaker, Grant D; Parlitsis, George; Cho, Minhee; D'Amico, Donald J; Kiss, Szilárd

2012-04-01

To evaluate patients with diabetic retinopathy using ultra-wide-field fluorescein angiography and to compare the visualized retinal pathology with that seen on an overly of conventional 7 standard field (7SF) imaging. Two hundred and eighteen eyes of 118 diabetic patients who underwent diagnostic fluorescein angiography using the Optos Optomap Panoramic 200A imaging system were included. The visualized area of the retina, retinal nonperfusion, retinal neovascularization, and panretinal photocoagulation were quantified by two independent masked graders. The respective areas identified on the ultra-wide-field fluorescein angiography image were compared with an overly of a modified 7SF image as outlined in the Early Treatment Diabetic Retinopathy Study. Ultra-wide-field fluorescein angiograms imaging, on average, demonstrated 3.2 times more total retinal surface area than 7SF. When compared with 7SF, ultra-wide-field fluorescein angiography showed 3.9 times more nonperfusion (P diabetic retinopathy. Improved retinal visualization may alter the classification of diabetic retinopathy and may therefore influence follow-up and treatment of these patients.

Michelson wide-field stellar interferometry : Principles and experimental verification

NARCIS (Netherlands)

Montilla, I.; Pereira, S.F.; Braat, J.J.M.

2005-01-01

A new interferometric technique for Michelson wide-field interferometry is presented that consists of a Michelson pupil-plane combination scheme in which a wide field of view can be achieved in one shot. This technique uses a stair-shaped mirror in the intermediate image plane of each telescope in

Advanced MOKE magnetometry in wide-field Kerr-microscopy

Science.gov (United States)

Soldatov, I. V.; Schäfer, R.

2017-10-01

The measurement of MOKE (Magneto-Optical Kerr Effect) magnetization loops in a wide-field Kerr microscope offers the advantage that the relevant domain images along the loop can be readily recorded. As the microscope's objective lens is exposed to the magnetic field, the loops are usually strongly distorted by non-linear Faraday rotations of the polarized light that occur in the objective lens and that are superimposed to the MOKE signal. In this paper, an experimental method, based on a motorized analyzer, is introduced which allows to compensate the Faraday contributions, thus leading to pure MOKE loops. A wide field Kerr microscope, equipped with this technology, works well as a laser-based MOKE magnetometer, additionally offering domain images and thus providing the basis for loop interpretation.

Wide-Field Imaging of Single-Nanoparticle Extinction with Sub-nm2 Sensitivity

Science.gov (United States)

Payne, Lukas M.; Langbein, Wolfgang; Borri, Paola

2018-03-01

We report on a highly sensitive wide-field imaging technique for quantitative measurement of the optical extinction cross section σext of single nanoparticles. The technique is simple and high speed, and it enables the simultaneous acquisition of hundreds of nanoparticles for statistical analysis. Using rapid referencing, fast acquisition, and a deconvolution analysis, a shot-noise-limited sensitivity down to 0.4 nm2 is achieved. Measurements on a set of individual gold nanoparticles of 5 nm diameter using this method yield σext=(10.0 ±3.1 ) nm2, which is consistent with theoretical expectations and well above the background fluctuations of 0.9 nm2 .

A wide field X-ray camera

International Nuclear Information System (INIS)

Sims, M.; Turner, M.J.L.; Willingale, R.

1980-01-01

A wide field of view X-ray camera based on the Dicke or Coded Mask principle is described. It is shown that this type of instrument is more sensitive than a pin-hole camera, or than a scanning survey of a given region of sky for all wide field conditions. The design of a practical camera is discussed and the sensitivity and performance of the chosen design are evaluated by means of computer simulations. The Wiener Filter and Maximum Entropy methods of deconvolution are described and these methods are compared with each other and cross-correlation using data from the computer simulations. It is shown that the analytic expressions for sensitivity used by other workers are confirmed by the simulations, and that ghost images caused by incomplete coding can be substantially eliminated by the use of the Wiener Filter and the Maximum Entropy Method, with some penalty in computer time for the latter. The cyclic mask configuration is compared with the simple mask camera. It is shown that when the diffuse X-ray background dominates, the simple system is more sensitive and has the better angular resolution. When sources dominate the simple system is less sensitive. It is concluded that the simple coded mask camera is the best instrument for wide field imaging of the X-ray sky. (orig.)

Wide-field surveys from the SNAP mission

International Nuclear Information System (INIS)

2002-01-01

The Supernova/Acceleration Probe (SNAP) is a proposed space-borne observatory that will survey the sky with a wide-field optical/NIR imager. The images produced by SNAP will have an unprecedented combination of depth, solid-angle, angular resolution, and temporal sampling. Two 7.5 square-degree fields will be observed every four days over 16 months to a magnitude depth of AB = 27.7 in each of nine filters. Co-adding images over all epochs will give an AB = 30.3 per filter. A 300 square-degree field will be surveyed with no repeat visits to AB = 28 per filter. The nine filters span 3500-17000 (angstrom). Although the survey strategy is tailored for supernova and weak gravitational lensing observations, the resulting data supports a broad range of auxiliary science programs

Wide-field imaging of birefringent synovial fluid crystals using lens-free polarized microscopy for gout diagnosis

Science.gov (United States)

Zhang, Yibo; Lee, Seung Yoon Celine; Zhang, Yun; Furst, Daniel; Fitzgerald, John; Ozcan, Aydogan

2016-06-01

Gout is a form of crystal arthropathy where monosodium urate (MSU) crystals deposit and elicit inflammation in a joint. Diagnosis of gout relies on identification of MSU crystals under a compensated polarized light microscope (CPLM) in synovial fluid aspirated from the patient’s joint. The detection of MSU crystals by optical microscopy is enhanced by their birefringent properties. However, CPLM partially suffers from the high-cost and bulkiness of conventional lens-based microscopy, and its relatively small field-of-view (FOV) limits the efficiency and accuracy of gout diagnosis. Here we present a lens-free polarized microscope which adopts a novel differential and angle-mismatched polarizing optical design achieving wide-field and high-resolution holographic imaging of birefringent objects with a color contrast similar to that of a standard CPLM. The performance of this computational polarization microscope is validated by imaging MSU crystals made from a gout patient’s tophus and steroid crystals used as negative control. This lens-free polarized microscope, with its wide FOV (>20 mm2), cost-effectiveness and field-portability, can significantly improve the efficiency and accuracy of gout diagnosis, reduce costs, and can be deployed even at the point-of-care and in resource-limited clinical settings.

Contributed review: camera-limits for wide-field magnetic resonance imaging with a nitrogen-vacancy spin sensor

DEFF Research Database (Denmark)

Wojciechowski, Adam M.; Karadas, Mürsel; Huck, Alexander

2018-01-01

Sensitive, real-time optical magnetometry with nitrogen-vacancy centers in diamond relies on accurate imaging of small (≪10−2), fractional fluorescence changes across the diamond sample. We discuss the limitations on magnetic field sensitivity resulting from the limited number of photoelectrons t......-level sensitivity in 1 s of a combined exposure. Finally, we demonstrate the results obtained with a lock-in camera that paves the way for real-time, wide-field magnetometry at the nanotesla level and with a micrometer resolution....

Effects of spatial and spectral frequencies on wide-field functional imaging (wifi) characterization of preclinical breast cancer models

Science.gov (United States)

Moy, Austin; Kim, Jae G.; Lee, Eva Y. H. P.; Choi, Bernard

2010-02-01

A common strategy to study breast cancer is the use of the preclinical model. These models provide a physiologically relevant and controlled environment in which to study both response to novel treatments and the biology of the cancer. Preclinical models, including the spontaneous tumor model and mammary window chamber model, are very amenable to optical imaging and to this end, we have developed a wide-field functional imaging (WiFI) instrument that is perfectly suited to studying tumor metabolism in preclinical models. WiFI combines two optical imaging modalities, spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI). Our current WiFI imaging protocol consists of multispectral imaging in the near infrared (650-980 nm) spectrum, over a wide (7 cm x 5 cm) field of view. Using SFDI, the spatially-resolved reflectance of sinusoidal patterns projected onto the tissue is assessed, and optical properties of the tissue are determined, which are then used to extract tissue chromophore concentrations in the form of oxy-, deoxy-, and total hemoglobin concentrations, and percentage of lipid and water. In the current study, we employ Monte Carlo simulations of SFDI light propagation in order to characterize the penetration depth of light in both the spontaneous tumor model and mammary window chamber model. Preliminary results suggest that different spatial frequency and wavelength combinations have different penetration depths, suggesting the potential depth sectioning capability of the SFDI component of WiFI.

Systems, computer-implemented methods, and tangible computer-readable storage media for wide-field interferometry

Science.gov (United States)

Lyon, Richard G. (Inventor); Leisawitz, David T. (Inventor); Rinehart, Stephen A. (Inventor); Memarsadeghi, Nargess (Inventor)

2012-01-01

Disclosed herein are systems, computer-implemented methods, and tangible computer-readable storage media for wide field imaging interferometry. The method includes for each point in a two dimensional detector array over a field of view of an image: gathering a first interferogram from a first detector and a second interferogram from a second detector, modulating a path-length for a signal from an image associated with the first interferogram in the first detector, overlaying first data from the modulated first detector and second data from the second detector, and tracking the modulating at every point in a two dimensional detector array comprising the first detector and the second detector over a field of view for the image. The method then generates a wide-field data cube based on the overlaid first data and second data for each point. The method can generate an image from the wide-field data cube.

Laser Light-field Fusion for Wide-field Lensfree On-chip Phase Contrast Microscopy of Nanoparticles

Science.gov (United States)

Kazemzadeh, Farnoud; Wong, Alexander

2016-12-01

Wide-field lensfree on-chip microscopy, which leverages holography principles to capture interferometric light-field encodings without lenses, is an emerging imaging modality with widespread interest given the large field-of-view compared to lens-based techniques. In this study, we introduce the idea of laser light-field fusion for lensfree on-chip phase contrast microscopy for detecting nanoparticles, where interferometric laser light-field encodings acquired using a lensfree, on-chip setup with laser pulsations at different wavelengths are fused to produce marker-free phase contrast images of particles at the nanometer scale. As a proof of concept, we demonstrate, for the first time, a wide-field lensfree on-chip instrument successfully detecting 300 nm particles across a large field-of-view of ~30 mm2 without any specialized or intricate sample preparation, or the use of synthetic aperture- or shift-based techniques.

Ultra-wide field imaging system and traditional retinal examinations for screening fundus changes after cataract surgery.

Science.gov (United States)

Peng, Jie; Zhang, Qi; Jin, Hai-Ying; Lu, Wu-Yi; Zhao, Pei-Quan

2016-01-01

To compare the results of non-mydriatic ultra-wide field imaging system, mydriatic slit-lamp lens (Volk +90 D) and mydriatic Goldmann three-mirror contact lens examinations in screening fundus lesions among patients after cataract surgery. Non-mydriatic images were obtained with an Optomap panoramic 200Tx (Optomap 200Tx) 3d after surgery and graded by a blinded ophthalmologist. A mydriatic slit-lamp lens examination was performed by another blinded retinal specialist on the same day. A third blinded retinal specialist examined patients two weeks after surgery using a Goldmann three-mirror contact lens. In total, 160 patients (184 eyes) were examined, and 66, 69, and 75 cases of retinal lesion(s) were identified using the Optomap 200Tx, slit-lamp lens, and Goldmann three-mirror contact lens, respectively. In 13 cases, fundus changes were sight-threatening. The results obtained by Optomap 200Tx examination and by mydriatic slit-lamp lens examination have good consistency (P=0.375, Kappa=0.942). The mydriatic Goldmann three-mirror lens examination revealed more fundus lesions but are consistent with Optomap 200Tx (P=0.004, Kappa=0.897) and mydriatic slit-lamp lens examination (P=0.031, Kappa=0.932). Early post-operative fundus screening in cataract patients is extremely important and necessary to prevent further vision loss. Wide-field imaging is a feasible and convenient tool for fundus examination that can be used as a primary screening method among patients after cataract surgery.

Simulations of the x-ray imaging capabilities of the silicon drift detectors (SDD) for the LOFT wide-field monitor

DEFF Research Database (Denmark)

Evangelista, Y.; Campana, R.; Del Monte, E.

2012-01-01

Detector (LAD), carrying an unprecedented effective area of 10 m^2, is complemented by a coded-mask Wide Field Monitor, in charge of monitoring a large fraction of the sky potentially accessible to the LAD, to provide the history and context for the sources observed by LAD and to trigger its observations...... on their most interesting and extreme states. In this paper we present detailed simulations of the imaging capabilities of the Silicon Drift Detectors developed for the LOFT Wide Field Monitor detection plane. The simulations explore a large parameter space for both the detector design and the environmental...

Towards an ultra-thin medical endoscope: multimode fibre as a wide-field image transferring medium

Science.gov (United States)

Duriš, Miroslav; Bradu, Adrian; Podoleanu, Adrian; Hughes, Michael

2018-03-01

Multimode optical fibres are attractive for biomedical and industrial applications such as endoscopes because of the small cross section and imaging resolution they can provide in comparison to widely-used fibre bundles. However, the image is randomly scrambled by propagation through a multimode fibre. Even though the scrambling is unpredictable, it is deterministic, and therefore the scrambling can be reversed. To unscramble the image, we treat the multimode fibre as a linear, disordered scattering medium. To calibrate, we scan a focused beam of coherent light over thousands of different beam positions at the distal end and record complex fields at the proximal end of the fibre. This way, the inputoutput response of the system is determined, which then allows computational reconstruction of reflection-mode images. However, there remains the problem of illuminating the tissue via the fibre while avoiding back reflections from the proximal face. To avoid this drawback, we provide here the first preliminary confirmation that an image can be transferred through a 2x2 fibre coupler, with the sample at its distal port interrogated in reflection. Light is injected into one port for illumination and then collected from a second port for imaging.

Wide-field schematic eye models with gradient-index lens.

Science.gov (United States)

Goncharov, Alexander V; Dainty, Chris

2007-08-01

We propose a wide-field schematic eye model, which provides a more realistic description of the optical system of the eye in relation to its anatomical structure. The wide-field model incorporates a gradient-index (GRIN) lens, which enables it to fulfill properties of two well-known schematic eye models, namely, Navarro's model for off-axis aberrations and Thibos's chromatic on-axis model (the Indiana eye). These two models are based on extensive experimental data, which makes the derived wide-field eye model also consistent with that data. A mathematical method to construct a GRIN lens with its iso-indicial contours following the optical surfaces of given asphericity is presented. The efficiency of the method is demonstrated with three variants related to different age groups. The role of the GRIN structure in relation to the lens paradox is analyzed. The wide-field model with a GRIN lens can be used as a starting design for the eye inverse problem, i.e., reconstructing the optical structure of the eye from off-axis wavefront measurements. Anatomically more accurate age-dependent optical models of the eye could ultimately help an optical designer to improve wide-field retinal imaging.

Comparative study between fundus autofluorescence and red reflectance imaging of choroidal nevi using ultra-wide-field scanning laser ophthalmoscopy.

Science.gov (United States)

Zapata, Miguel Angel; Leila, Mahmoud; Teixidor, Teresa; Garcia-Arumi, Jose

2015-06-01

To explore the utility of fundus autofluorescence (FAF) and red reflectance (RR) imaging using ultra-wide-field scanning laser ophthalmoscope in choroidal nevi. Retrospective observational case study reviewing clinical data, color, FAF, and RR images of patients with choroidal nevi and comparing the findings. The ultra-wide-field scanning laser ophthalmoscope uses green laser 532 nm and red laser 633 nm that enabled FAF and RR imaging, respectively in separate channels. Superimposition of both images yielded a composite color image. The study included 46 eyes of 45 patients. Nevi were unilateral in 44 patients (98%). Forty-one nevi (89.1%) were located temporally between the macula and the equator. All nevi (100%) were deeply pigmented. The most frequent surface changes were lipofuscin pigments, zones of retinal pigment epithelium atrophy, and retinal pigment epithelium pigment clumps in 31 (67.3%), 18 (39.1%), and 8 eyes (17.3%), respectively. Color photographs were superior to FAF in detecting nevus boundaries and surface changes. Red reflectance correlated strongly with color images, although the nevus boundaries and surface changes were better delineated in RR mode. Red reflectance was superior to FAF in delineating the boundaries and surface changes of the nevus; clear visibility (3+) for RR versus no or poor visibility (0/1+) for FAF. Nevertheless, the areas of retinal pigment epithelium atrophy were better delineated in FAF mode; clear visibility (3+) for FAF versus poor visibility (1+) for FAF. Red reflectance imaging is more sensitive than conventional photography for follow-up of choroidal nevi. Fundus autofluorescence should be considered only as a complementary tool to RR imaging.

UVUDF: Ultraviolet imaging of the Hubble ultra deep field with wide-field camera 3

Energy Technology Data Exchange (ETDEWEB)

Teplitz, Harry I.; Rafelski, Marc; Colbert, James W.; Hanish, Daniel J. [Infrared Processing and Analysis Center, MS 100-22, Caltech, Pasadena, CA 91125 (United States); Kurczynski, Peter; Gawiser, Eric [Department of Physics and Astronomy, Rutgers University, Piscataway, NJ 08854 (United States); Bond, Nicholas A.; Gardner, Jonathan P.; De Mello, Duilia F. [Laboratory for Observational Cosmology, Astrophysics Science Division, Code 665, Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Grogin, Norman; Koekemoer, Anton M.; Brown, Thomas M.; Coe, Dan; Ferguson, Henry C. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Atek, Hakim [Laboratoire d' Astrophysique, École Polytechnique Fédérale de Lausanne (EPFL), Observatoire, CH-1290 Sauverny (Switzerland); Finkelstein, Steven L. [Department of Astronomy, The University of Texas at Austin, Austin, TX 78712 (United States); Giavalisco, Mauro [Astronomy Department, University of Massachusetts, Amherst, MA 01003 (United States); Gronwall, Caryl [Department of Astronomy and Astrophysics, The Pennsylvania State University, University Park, PA 16802 (United States); Lee, Kyoung-Soo [Department of Physics, Purdue University, 525 Northwestern Avenue, West Lafayette, IN 47907 (United States); Ravindranath, Swara, E-mail: hit@ipac.caltech.edu [Inter-University Centre for Astronomy and Astrophysics, Pune (India); and others

2013-12-01

We present an overview of a 90 orbit Hubble Space Telescope treasury program to obtain near-ultraviolet imaging of the Hubble Ultra Deep Field using the Wide Field Camera 3 UVIS detector with the F225W, F275W, and F336W filters. This survey is designed to: (1) investigate the episode of peak star formation activity in galaxies at 1 < z < 2.5; (2) probe the evolution of massive galaxies by resolving sub-galactic units (clumps); (3) examine the escape fraction of ionizing radiation from galaxies at z ∼ 2-3; (4) greatly improve the reliability of photometric redshift estimates; and (5) measure the star formation rate efficiency of neutral atomic-dominated hydrogen gas at z ∼ 1-3. In this overview paper, we describe the survey details and data reduction challenges, including both the necessity of specialized calibrations and the effects of charge transfer inefficiency. We provide a stark demonstration of the effects of charge transfer inefficiency on resultant data products, which when uncorrected, result in uncertain photometry, elongation of morphology in the readout direction, and loss of faint sources far from the readout. We agree with the STScI recommendation that future UVIS observations that require very sensitive measurements use the instrument's capability to add background light through a 'post-flash'. Preliminary results on number counts of UV-selected galaxies and morphology of galaxies at z ∼ 1 are presented. We find that the number density of UV dropouts at redshifts 1.7, 2.1, and 2.7 is largely consistent with the number predicted by published luminosity functions. We also confirm that the image mosaics have sufficient sensitivity and resolution to support the analysis of the evolution of star-forming clumps, reaching 28-29th magnitude depth at 5σ in a 0.''2 radius aperture depending on filter and observing epoch.

Contributed Review: Camera-limits for wide-field magnetic resonance imaging with a nitrogen-vacancy spin sensor

Science.gov (United States)

Wojciechowski, Adam M.; Karadas, Mürsel; Huck, Alexander; Osterkamp, Christian; Jankuhn, Steffen; Meijer, Jan; Jelezko, Fedor; Andersen, Ulrik L.

2018-03-01

Sensitive, real-time optical magnetometry with nitrogen-vacancy centers in diamond relies on accurate imaging of small (≪10-2), fractional fluorescence changes across the diamond sample. We discuss the limitations on magnetic field sensitivity resulting from the limited number of photoelectrons that a camera can record in a given time. Several types of camera sensors are analyzed, and the smallest measurable magnetic field change is estimated for each type. We show that most common sensors are of a limited use in such applications, while certain highly specific cameras allow achieving nanotesla-level sensitivity in 1 s of a combined exposure. Finally, we demonstrate the results obtained with a lock-in camera that paves the way for real-time, wide-field magnetometry at the nanotesla level and with a micrometer resolution.

Wide-Field Imaging of Omega Centauri with the Advanced Camera for Surveys

Science.gov (United States)

Haggard, D.; Dorfman, J. L.; Cool, A. M.; Anderson, J.; Bailyn, C. D.; Edmonds, P. D.; Grindlay, J. E.

2003-12-01

We present initial results of a wide-field imaging study of the globular cluster Omega Cen (NGC 5139) using the Advanced Camera for Surveys (ACS). We have obtained a mosaic of 3x3 pointings of the cluster using the HST/ACS Wide Field Camera covering approximately 10' x 10', roughly out to the cluster's half-mass radius. Using F435W (B435), F625W (R625) and F658N (H-alpha) filters, we are searching for optical counterparts of Chandra X-ray sources and studying the cluster's stellar populations. Here we report the discovery of an optical counterpart to the X-ray source identified by Rutledge et al. (2002) as a possible quiescent neutron star on the basis of its X-ray spectrum. The star's magnitude and color (R625 = 24.4, B435-R625 = 1.5) place it more than 1.5 magnitudes to the blue side of the main sequence. Through the H-alpha filter it is about 1.3 magnitudes brighter than cluster stars of comparable R625 magnitude. The blue color and H-alpha excess suggest the presence of an accretion disk, implying that the neutron star is a member of a quiescent low-mass X-ray binary. The object's faint absolute magnitude (M625 ˜ 10.6, M435 ˜ 11.8) implies that the system contains an unusually weak disk and that the companion, if it is a main-sequence star, is of very low mass (ACS study. This work is supported by NASA grant GO-9442 from the Space Telescope Science Institute.

A Wide-Field, Broadband Imaging Survey of Butcher-Oemler Cluster Cl 0024+1654: The Catalog

Science.gov (United States)

Alexov, A.; Silva, D. R.; Pierce, M. J.

2003-12-01

Wide-field (20'×20') UBVI images of intermediate-redshift (z=0.39), Butcher-Oemler cluster Cl 0024+1654 have been obtained. These data probe the rest-frame mid-UV properties over a much larger area than previous studies of Cl 0024+1654. Using these data, a multicolor catalog of nonstellar objects, assumed to be galaxies, has been constructed and analyzed. Using statistical arguments, the observed galaxy sample is separated into field and cluster populations. The basic photometric properties of these populations are presented and discussed. The ``dropout'' objects (i.e., objects undetected in one or more photometric bands) in our catalog are also discussed. A description of the final UBVI images, as well as the object catalog, is provided in an appendix. In a second appendix the use of SExtractor in crowded fields, such as the core of Cl 0024+1654, is discussed. The specific issues of the mid-UV properties of red envelope cluster galaxies, as well as the possible detection of a faint blue cluster population, are discussed in a forthcoming companion paper by Silva, Alexov, & Pierce. The observations described were conducted at Kitt Peak National Observatory, National Optical Astronomy Observatory, which is operated by the Association of Universities for Research in Astronomy (AURA) Inc., under cooperative agreement with the National Science Foundation (NSF).

Non-mydriatic, wide field, fundus video camera

Science.gov (United States)

Hoeher, Bernhard; Voigtmann, Peter; Michelson, Georg; Schmauss, Bernhard

2014-02-01

We describe a method we call "stripe field imaging" that is capable of capturing wide field color fundus videos and images of the human eye at pupil sizes of 2mm. This means that it can be used with a non-dilated pupil even with bright ambient light. We realized a mobile demonstrator to prove the method and we could acquire color fundus videos of subjects successfully. We designed the demonstrator as a low-cost device consisting of mass market components to show that there is no major additional technical outlay to realize the improvements we propose. The technical core idea of our method is breaking the rotational symmetry in the optical design that is given in many conventional fundus cameras. By this measure we could extend the possible field of view (FOV) at a pupil size of 2mm from a circular field with 20° in diameter to a square field with 68° by 18° in size. We acquired a fundus video while the subject was slightly touching and releasing the lid. The resulting video showed changes at vessels in the region of the papilla and a change of the paleness of the papilla.

Wide field-of-view dual-band multispectral muzzle flash detection

Science.gov (United States)

Montoya, J.; Melchor, J.; Spiliotis, P.; Taplin, L.

2013-06-01

Sensor technologies are undergoing revolutionary advances, as seen in the rapid growth of multispectral methodologies. Increases in spatial, spectral, and temporal resolution, and in breadth of spectral coverage, render feasible sensors that function with unprecedented performance. A system was developed that addresses many of the key hardware requirements for a practical dual-band multispectral acquisition system, including wide field of view and spectral/temporal shift between dual bands. The system was designed using a novel dichroic beam splitter and dual band-pass filter configuration that creates two side-by-side images of a scene on a single sensor. A high-speed CMOS sensor was used to simultaneously capture data from the entire scene in both spectral bands using a short focal-length lens that provided a wide field-of-view. The beam-splitter components were arranged such that the two images were maintained in optical alignment and real-time intra-band processing could be carried out using only simple arithmetic on the image halves. An experiment related to limitations of the system to address multispectral detection requirements was performed. This characterized the system's low spectral variation across its wide field of view. This paper provides lessons learned on the general limitation of key hardware components required for multispectral muzzle flash detection, using the system as a hardware example combined with simulated multispectral muzzle flash and background signatures.

Development of a wide-field fluorescence imaging system for evaluation of wound re-epithelialization

Science.gov (United States)

Franco, Walfre; Gutierrez-Herrera, Enoch; Purschke, Martin; Wang, Ying; Tam, Josh; Anderson, R. Rox; Doukas, Apostolos

2013-03-01

Normal skin barrier function depends on having a viable epidermis, an epithelial layer formed by keratinocytes. The transparent epidermis, which is less than a 100 mum thick, is nearly impossible to see. Thus, the clinical evaluation of re-epithelialization is difficult, which hinders selecting appropriate therapy for promoting wound healing. An imaging system was developed to evaluate epithelialization by detecting endogenous fluorescence emissions of cellular proliferation over a wide field of view. A custom-made 295 nm ultraviolet (UV) light source was used for excitation. Detection was done by integrating a near-UV camera with sensitivity down to 300 nm, a 12 mm quartz lens with iris and focus lock for the UV regime, and a fluorescence bandpass filter with 340 nm center wavelength. To demonstrate that changes in fluorescence are related to cellular processes, the epithelialization of a skin substitute was monitored in vitro. The skin substitute or construct was made by embedding microscopic live human skin tissue columns, 1 mm in diameter and spaced 1 mm apart, in acellular porcine dermis. Fluorescence emissions clearly delineate the extent of lateral surface migration of keratinocytes and the total surface covered by the new epithelium. The fluorescence image of new epidermis spatially correlates with the corresponding color image. A simple, user-friendly way of imaging the presence of skin epithelium would improve wound care in civilian burns, ulcers and surgeries.

Light field imaging and application analysis in THz

Science.gov (United States)

Zhang, Hongfei; Su, Bo; He, Jingsuo; Zhang, Cong; Wu, Yaxiong; Zhang, Shengbo; Zhang, Cunlin

2018-01-01

The light field includes the direction information and location information. Light field imaging can capture the whole light field by single exposure. The four-dimensional light field function model represented by two-plane parameter, which is proposed by Levoy, is adopted in the light field. Acquisition of light field is based on the microlens array, camera array and the mask. We calculate the dates of light-field to synthetize light field image. The processing techniques of light field data include technology of refocusing rendering, technology of synthetic aperture and technology of microscopic imaging. Introducing the technology of light field imaging into THz, the efficiency of 3D imaging is higher than that of conventional THz 3D imaging technology. The advantages compared with visible light field imaging include large depth of field, wide dynamic range and true three-dimensional. It has broad application prospects.

Wide-field absolute transverse blood flow velocity mapping in vessel centerline

Science.gov (United States)

Wu, Nanshou; Wang, Lei; Zhu, Bifeng; Guan, Caizhong; Wang, Mingyi; Han, Dingan; Tan, Haishu; Zeng, Yaguang

2018-02-01

We propose a wide-field absolute transverse blood flow velocity measurement method in vessel centerline based on absorption intensity fluctuation modulation effect. The difference between the light absorption capacities of red blood cells and background tissue under low-coherence illumination is utilized to realize the instantaneous and average wide-field optical angiography images. The absolute fuzzy connection algorithm is used for vessel centerline extraction from the average wide-field optical angiography. The absolute transverse velocity in the vessel centerline is then measured by a cross-correlation analysis according to instantaneous modulation depth signal. The proposed method promises to contribute to the treatment of diseases, such as those related to anemia or thrombosis.

Wide-field spectral imaging of human ovary autofluorescence and oncologic diagnosis via previously collected probe data

Science.gov (United States)

Renkoski, Timothy E.; Hatch, Kenneth D.; Utzinger, Urs

2012-03-01

With no sufficient screening test for ovarian cancer, a method to evaluate the ovarian disease state quickly and nondestructively is needed. The authors have applied a wide-field spectral imager to freshly resected ovaries of 30 human patients in a study believed to be the first of its magnitude. Endogenous fluorescence was excited with 365-nm light and imaged in eight emission bands collectively covering the 400- to 640-nm range. Linear discriminant analysis was used to classify all image pixels and generate diagnostic maps of the ovaries. Training the classifier with previously collected single-point autofluorescence measurements of a spectroscopic probe enabled this novel classification. The process by which probe-collected spectra were transformed for comparison with imager spectra is described. Sensitivity of 100% and specificity of 51% were obtained in classifying normal and cancerous ovaries using autofluorescence data alone. Specificity increased to 69% when autofluorescence data were divided by green reflectance data to correct for spatial variation in tissue absorption properties. Benign neoplasm ovaries were also found to classify as nonmalignant using the same algorithm. Although applied ex vivo, the method described here appears useful for quick assessment of cancer presence in the human ovary.

THE COSMIC INFRARED BACKGROUND EXPERIMENT (CIBER): THE WIDE-FIELD IMAGERS

Energy Technology Data Exchange (ETDEWEB)

Bock, J.; Battle, J. [Jet Propulsion Laboratory (JPL), National Aeronautics and Space Administration (NASA), Pasadena, CA 91109 (United States); Sullivan, I. [Department of Physics, University of Washington, Seattle, WA 98195 (United States); Arai, T.; Matsumoto, T.; Matsuura, S.; Tsumura, K. [Department of Space Astronomy and Astrophysics, Institute of Space and Astronautical Science (ISAS), Japan Aerospace Exploration Agency (JAXA), Sagamihara, Kanagawa 252-5210 (Japan); Cooray, A.; Mitchell-Wynne, K.; Smidt, J. [Center for Cosmology, University of California, Irvine, CA 92697 (United States); Hristov, V.; Lam, A. C.; Levenson, L. R.; Mason, P. [Department of Physics, Mathematics and Astronomy, California Institute of Technology, Pasadena, CA 91125 (United States); Keating, B.; Renbarger, T. [Department of Physics, University of California, San Diego, San Diego, CA 92093 (United States); Kim, M. G. [Department of Physics and Astronomy, Seoul National University, Seoul 151-742 (Korea, Republic of); Lee, D. H. [Institute of Astronomy and Astrophysics, Academia Sinica, National Taiwan University, Taipei 10617, Taiwan (China); Nam, U. W. [Korea Astronomy and Space Science Institute (KASI), Daejeon 305-348 (Korea, Republic of); Suzuki, K. [Instrument Development Group of Technical Center, Nagoya University, Nagoya, Aichi 464-8602 (Japan); and others

2013-08-15

We have developed and characterized an imaging instrument to measure the spatial properties of the diffuse near-infrared extragalactic background light (EBL) in a search for fluctuations from z > 6 galaxies during the epoch of reionization. The instrument is part of the Cosmic Infrared Background Experiment (CIBER), designed to observe the EBL above Earth's atmosphere during a suborbital sounding rocket flight. The imaging instrument incorporates a 2 Degree-Sign Multiplication-Sign 2 Degree-Sign field of view to measure fluctuations over the predicted peak of the spatial power spectrum at 10 arcmin, and 7'' Multiplication-Sign 7'' pixels, to remove lower redshift galaxies to a depth sufficient to reduce the low-redshift galaxy clustering foreground below instrumental sensitivity. The imaging instrument employs two cameras with {Delta}{lambda}/{lambda} {approx} 0.5 bandpasses centered at 1.1 {mu}m and 1.6 {mu}m to spectrally discriminate reionization extragalactic background fluctuations from local foreground fluctuations. CIBER operates at wavelengths where the electromagnetic spectrum of the reionization extragalactic background is thought to peak, and complements fluctuation measurements by AKARI and Spitzer at longer wavelengths. We have characterized the instrument in the laboratory, including measurements of the sensitivity, flat-field response, stray light performance, and noise properties. Several modifications were made to the instrument following a first flight in 2009 February. The instrument performed to specifications in three subsequent flights, and the scientific data are now being analyzed.

Imaging Cajal's neuronal avalanche: how wide-field optical imaging of the point-spread advanced the understanding of neocortical structure-function relationship.

Science.gov (United States)

Frostig, Ron D; Chen-Bee, Cynthia H; Johnson, Brett A; Jacobs, Nathan S

2017-07-01

This review brings together a collection of studies that specifically use wide-field high-resolution mesoscopic level imaging techniques (intrinsic signal optical imaging; voltage-sensitive dye optical imaging) to image the cortical point spread (PS): the total spread of cortical activation comprising a large neuronal ensemble evoked by spatially restricted (point) stimulation of the sensory periphery (e.g., whisker, pure tone, point visual stimulation). The collective imaging findings, combined with supporting anatomical and electrophysiological findings, revealed some key aspects about the PS including its very large (radius of several mm) and relatively symmetrical spatial extent capable of crossing cytoarchitectural borders and trespassing into other cortical areas; its relationship with underlying evoked subthreshold activity and underlying anatomical system of long-range horizontal projections within gray matter, both also crossing borders; its contextual modulation and plasticity; the ability of its relative spatiotemporal profile to remain invariant to major changes in stimulation parameters; its potential role as a building block for integrative cortical activity; and its ubiquitous presence across various cortical areas and across mammalian species. Together, these findings advance our understanding about the neocortex at the mesoscopic level by underscoring that the cortical PS constitutes a fundamental motif of neocortical structure-function relationship.

Wide-field Spatio-Spectral Interferometry: Bringing High Resolution to the Far- Infrared

Science.gov (United States)

Leisawitx, David

Wide-field spatio-spectral interferometry combines spatial and spectral interferometric data to provide integral field spectroscopic information over a wide field of view. This technology breaks through a mission cost barrier that stands in the way of resolving spatially and measuring spectroscopically at far-infrared wavelengths objects that will lead to a deep understanding of planetary system and galaxy formation processes. A space-based far-IR interferometer will combine Spitzer s superb sensitivity with a two order of magnitude gain in angular resolution, and with spectral resolution in the thousands. With the possible exception of detector technology, which is advancing with support from other research programs, the greatest challenge for far-IR interferometry is to demonstrate that the interferometer will actually produce the images and spectra needed to satisfy mission science requirements. With past APRA support, our team has already developed the highly specialized hardware testbed, image projector, computational model, and image construction software required for the proposed effort, and we have access to an ideal test facility.

Wide-field optical mapping of neural activity and brain haemodynamics: considerations and novel approaches

Science.gov (United States)

Ma, Ying; Shaik, Mohammed A.; Kozberg, Mariel G.; Thibodeaux, David N.; Zhao, Hanzhi T.; Yu, Hang

2016-01-01

Although modern techniques such as two-photon microscopy can now provide cellular-level three-dimensional imaging of the intact living brain, the speed and fields of view of these techniques remain limited. Conversely, two-dimensional wide-field optical mapping (WFOM), a simpler technique that uses a camera to observe large areas of the exposed cortex under visible light, can detect changes in both neural activity and haemodynamics at very high speeds. Although WFOM may not provide single-neuron or capillary-level resolution, it is an attractive and accessible approach to imaging large areas of the brain in awake, behaving mammals at speeds fast enough to observe widespread neural firing events, as well as their dynamic coupling to haemodynamics. Although such wide-field optical imaging techniques have a long history, the advent of genetically encoded fluorophores that can report neural activity with high sensitivity, as well as modern technologies such as light emitting diodes and sensitive and high-speed digital cameras have driven renewed interest in WFOM. To facilitate the wider adoption and standardization of WFOM approaches for neuroscience and neurovascular coupling research, we provide here an overview of the basic principles of WFOM, considerations for implementation of wide-field fluorescence imaging of neural activity, spectroscopic analysis and interpretation of results. This article is part of the themed issue ‘Interpreting BOLD: a dialogue between cognitive and cellular neuroscience’. PMID:27574312

Wide-field optical mapping of neural activity and brain haemodynamics: considerations and novel approaches.

Science.gov (United States)

Ma, Ying; Shaik, Mohammed A; Kim, Sharon H; Kozberg, Mariel G; Thibodeaux, David N; Zhao, Hanzhi T; Yu, Hang; Hillman, Elizabeth M C

2016-10-05

Although modern techniques such as two-photon microscopy can now provide cellular-level three-dimensional imaging of the intact living brain, the speed and fields of view of these techniques remain limited. Conversely, two-dimensional wide-field optical mapping (WFOM), a simpler technique that uses a camera to observe large areas of the exposed cortex under visible light, can detect changes in both neural activity and haemodynamics at very high speeds. Although WFOM may not provide single-neuron or capillary-level resolution, it is an attractive and accessible approach to imaging large areas of the brain in awake, behaving mammals at speeds fast enough to observe widespread neural firing events, as well as their dynamic coupling to haemodynamics. Although such wide-field optical imaging techniques have a long history, the advent of genetically encoded fluorophores that can report neural activity with high sensitivity, as well as modern technologies such as light emitting diodes and sensitive and high-speed digital cameras have driven renewed interest in WFOM. To facilitate the wider adoption and standardization of WFOM approaches for neuroscience and neurovascular coupling research, we provide here an overview of the basic principles of WFOM, considerations for implementation of wide-field fluorescence imaging of neural activity, spectroscopic analysis and interpretation of results.This article is part of the themed issue 'Interpreting BOLD: a dialogue between cognitive and cellular neuroscience'. © 2016 The Authors.

Honeywell's Compact, Wide-angle Uv-visible Imaging Sensor

Science.gov (United States)

Pledger, D.; Billing-Ross, J.

1993-01-01

Honeywell is currently developing the Earth Reference Attitude Determination System (ERADS). ERADS determines attitude by imaging the entire Earth's limb and a ring of the adjacent star field in the 2800-3000 A band of the ultraviolet. This is achieved through the use of a highly nonconventional optical system, an intensifier tube, and a mega-element CCD array. The optics image a 30 degree region in the center of the field, and an outer region typically from 128 to 148 degrees, which can be adjusted up to 180 degrees. Because of the design employed, the illumination at the outer edge of the field is only some 15 percent below that at the center, in contrast to the drastic rolloffs encountered in conventional wide-angle sensors. The outer diameter of the sensor is only 3 in; the volume and weight of the entire system, including processor, are 1000 cc and 6 kg, respectively.

Wide-field two-dimensional multifocal optical-resolution photoacoustic computed microscopy

Science.gov (United States)

Xia, Jun; Li, Guo; Wang, Lidai; Nasiriavanaki, Mohammadreza; Maslov, Konstantin; Engelbach, John A.; Garbow, Joel R.; Wang, Lihong V.

2014-01-01

Optical-resolution photoacoustic microscopy (OR-PAM) is an emerging technique that directly images optical absorption in tissue at high spatial resolution. To date, the majority of OR-PAM systems are based on single focused optical excitation and ultrasonic detection, limiting the wide-field imaging speed. While one-dimensional multifocal OR-PAM (1D-MFOR-PAM) has been developed, the potential of microlens and transducer arrays has not been fully realized. Here, we present the development of two-dimensional multifocal optical-resolution photoacoustic computed microscopy (2D-MFOR-PACM), using a 2D microlens array and a full-ring ultrasonic transducer array. The 10 × 10 mm2 microlens array generates 1800 optical foci within the focal plane of the 512-element transducer array, and raster scanning the microlens array yields optical-resolution photoacoustic images. The system has improved the in-plane resolution of a full-ring transducer array from ≥100 µm to 29 µm and achieved an imaging time of 36 seconds over a 10 × 10 mm2 field of view. In comparison, the 1D-MFOR-PAM would take more than 4 minutes to image over the same field of view. The imaging capability of the system was demonstrated on phantoms and animals both ex vivo and in vivo. PMID:24322226

Radiometric calibration of wide-field camera system with an application in astronomy

Science.gov (United States)

Vítek, Stanislav; Nasyrova, Maria; Stehlíková, Veronika

2017-09-01

Camera response function (CRF) is widely used for the description of the relationship between scene radiance and image brightness. Most common application of CRF is High Dynamic Range (HDR) reconstruction of the radiance maps of imaged scenes from a set of frames with different exposures. The main goal of this work is to provide an overview of CRF estimation algorithms and compare their outputs with results obtained under laboratory conditions. These algorithms, typically designed for multimedia content, are unfortunately quite useless with astronomical image data, mostly due to their nature (blur, noise, and long exposures). Therefore, we propose an optimization of selected methods to use in an astronomical imaging application. Results are experimentally verified on the wide-field camera system using Digital Single Lens Reflex (DSLR) camera.

Michelson wide-field stellar interferometry

NARCIS (Netherlands)

Montilla, I.

2004-01-01

The main goal of this thesis is to develop a system to permit wide field operation of Michelson Interferometers. A wide field of view is very important in applications such as the observation of extended or multiple objects, the fringe acquisition and/ or tracking on a nearby unresolved object, and

Design, manufacturing and testing of a four-mirror telescope with a wide field of view

Science.gov (United States)

Gloesener, P.; Wolfs, F.; Lemagne, F.; Cola, M.; Flebus, C.; Blanchard, G.; Kirschner, V.

2017-11-01

Regarding Earth observation missions, it has become unnecessary to point out the importance of making available wide field of view optical instruments for the purpose of spectral imaging. Taking advantage of the pushbroom instrument concept with its linear field across the on-ground track, it is in particular relevant to consider front-end optical configurations that involve an all-reflective system presenting inherent and dedicated advantages such as achromaticity, unobscuration and compactness, while ensuring the required image quality over the whole field. The attractiveness of the concept must be balanced with respect to the state-of-the-art mirror manufacturing technologies as the need for fast, broadband and wide field systems increases the constraints put on the feasibility of each individual component. As part of an ESTEC contract, AMOS designed, manufactured and tested a breadboard of a four-mirror wide field telescope for typical Earth observation superspectral missions. The initial purpose of the development was to assess the feasibility of a telecentric spaceborne three-mirror system covering an unobscured rectangular field of view of 26 degrees across track (ACT) by 6 degrees along track (ALT) with a f-number of 3.5 and a focal length of 500 mm and presenting an overall image quality better than 100 nm RMS wavefront error within the whole field.

Picosecond wide-field time-correlated single photon counting fluorescence microscopy with a delay line anode detector

Energy Technology Data Exchange (ETDEWEB)

Hirvonen, Liisa M.; Le Marois, Alix; Suhling, Klaus, E-mail: klaus.suhling@kcl.ac.uk [Department of Physics, King' s College London, Strand, London WC2R 2LS (United Kingdom); Becker, Wolfgang; Smietana, Stefan [Becker & Hickl GmbH, Nahmitzer Damm 30, 12277 Berlin (Germany); Milnes, James; Conneely, Thomas [Photek Ltd., 26 Castleham Rd, Saint Leonards-on-Sea TN38 9NS (United Kingdom); Jagutzki, Ottmar [Institut für Kernphysik, Max-von-Laue-Str. 1, 60438 Frankfurt (Germany)

2016-08-15

We perform wide-field time-correlated single photon counting-based fluorescence lifetime imaging (FLIM) with a crossed delay line anode image intensifier, where the pulse propagation time yields the photon position. This microchannel plate-based detector was read out with conventional fast timing electronics and mounted on a fluorescence microscope with total internal reflection (TIR) illumination. The picosecond time resolution of this detection system combines low illumination intensity of microwatts with wide-field data collection. This is ideal for fluorescence lifetime imaging of cell membranes using TIR. We show that fluorescence lifetime images of living HeLa cells stained with membrane dye di-4-ANEPPDHQ exhibit a reduced lifetime near the coverslip in TIR compared to epifluorescence FLIM.

3D wide field-of-view Gabor-domain optical coherence microscopy advancing real-time in-vivo imaging and metrology

Science.gov (United States)

Canavesi, Cristina; Cogliati, Andrea; Hayes, Adam; Tankam, Patrice; Santhanam, Anand; Rolland, Jannick P.

2017-02-01

Real-time volumetric high-definition wide-field-of-view in-vivo cellular imaging requires micron-scale resolution in 3D. Compactness of the handheld device and distortion-free images with cellular resolution are also critically required for onsite use in clinical applications. By integrating a custom liquid lens-based microscope and a dual-axis MEMS scanner in a compact handheld probe, Gabor-domain optical coherence microscopy (GD-OCM) breaks the lateral resolution limit of optical coherence tomography through depth, overcoming the tradeoff between numerical aperture and depth of focus, enabling advances in biotechnology. Furthermore, distortion-free imaging with no post-processing is achieved with a compact, lightweight handheld MEMS scanner that obtained a 12-fold reduction in volume and 17-fold reduction in weight over a previous dual-mirror galvanometer-based scanner. Approaching the holy grail of medical imaging - noninvasive real-time imaging with histologic resolution - GD-OCM demonstrates invariant resolution of 2 μm throughout a volume of 1 x 1 x 0.6 mm3, acquired and visualized in less than 2 minutes with parallel processing on graphics processing units. Results on the metrology of manufactured materials and imaging of human tissue with GD-OCM are presented.

An automated wide-field time-gated optically sectioning fluorescence lifetime imaging multiwell plate reader for high-content analysis of protein-protein interactions

Science.gov (United States)

Alibhai, Dominic; Kumar, Sunil; Kelly, Douglas; Warren, Sean; Alexandrov, Yuriy; Munro, Ian; McGinty, James; Talbot, Clifford; Murray, Edward J.; Stuhmeier, Frank; Neil, Mark A. A.; Dunsby, Chris; French, Paul M. W.

2011-03-01

We describe an optically-sectioned FLIM multiwell plate reader that combines Nipkow microscopy with wide-field time-gated FLIM, and its application to high content analysis of FRET. The system acquires sectioned FLIM images in fluorescent protein. It has been applied to study the formation of immature HIV virus like particles (VLPs) in live cells by monitoring Gag-Gag protein interactions using FLIM FRET of HIV-1 Gag transfected with CFP or YFP. VLP formation results in FRET between closely packed Gag proteins, as confirmed by our FLIM analysis that includes automatic image segmentation.

Brca1/p53 deficient mouse breast tumor hemodynamics during hyperoxic respiratory challenge monitored by a novel wide-field functional imaging (WiFI) system

Science.gov (United States)

Moy, Austin; Kim, Jae G.; Lee, Eva Y. H. P.; Tromberg, Bruce; Cerussi, Albert; Choi, Bernard

2009-02-01

Current imaging modalities allow precise visualization of tumors but do not enable quantitative characterization of the tumor metabolic state. Such quantitative information would enhance our understanding of tumor progression and response to treatment, and to our overall understanding of tumor biology. To address this problem, we have developed a wide-field functional imaging (WiFI) instrument which combines two optical imaging modalities, spatially modulated imaging (MI) and laser speckle imaging (LSI). Our current WiFI imaging protocol consists of multispectral imaging in the near infrared (650-980 nm) spectrum, over a wide (7 cm × 5 cm) field of view. Using MI, the spatially-resolved reflectance of sinusoidal patterns projected onto the tissue is assessed, and optical properties of the tissue are estimated using a Monte Carlo model. From the spatial maps of local absorption and reduced scattering coefficients, tissue composition information is extracted in the form of oxy-, deoxy-, and total hemoglobin concentrations, and percentage of lipid and water. Using LSI, the reflectance of a 785 nm laser speckle pattern on the tissue is acquired and analyzed to compute maps of blood perfusion in the tissue. Tissue metabolism state is estimated from the values of blood perfusion, volume and oxygenation state. We currently are employing the WiFI instrument to study tumor development in a BRCA1/p53 deficient mice breast tumor model. The animals are monitored with WiFI during hyperoxic respiratory challenge. At present, four tumors have been measured with WiFI, and preliminary data suggest that tumor metabolic changes during hyperoxic respiratory challenge can be determined.

Simple concept for a wide-field lensless digital holographic microscope using a laser diode

Directory of Open Access Journals (Sweden)

Adinda-Ougba A.

2015-09-01

Full Text Available Wide-field, lensless digital holographic microscopy is a new microscopic imaging technique for telemedicine and for resource limited setting [1]. In this contribution we propose a very simple wide-field lensless digital holographic microscope using a laser diode. It is based on in-line digital holography which is capable to provide amplitude and phase images of a sample resulting from numerical reconstruction. The numerical reconstruction consists of the angular spectrum propagation method together with a phase retrieval algorithm. Amplitude and phase images of the sample with a resolution of ∽2 µm and with ∽24 mm2 field of view are obtained. We evaluate our setup by imaging first the 1951 USAF resolution test chart to verify the resolution. Second, we record holograms of blood smear and diatoms. The individual specimen can be easily identified after the numerical reconstruction. Our system is a very simple, compact and low-cost possibility of realizing a microscope capable of imaging biological samples. The availability of the phase provide topographic information of the sample extending the application of this system to be not only for biological sample but also for transparent microstructure. It is suitable for fault detection, shape and roughness measurements of these structures.

A generalized measurement equation and van Cittert-Zernike theorem for wide-field radio astronomical interferometry

Science.gov (United States)

Carozzi, T. D.; Woan, G.

2009-05-01

We derive a generalized van Cittert-Zernike (vC-Z) theorem for radio astronomy that is valid for partially polarized sources over an arbitrarily wide field of view (FoV). The classical vC-Z theorem is the theoretical foundation of radio astronomical interferometry, and its application is the basis of interferometric imaging. Existing generalized vC-Z theorems in radio astronomy assume, however, either paraxiality (narrow FoV) or scalar (unpolarized) sources. Our theorem uses neither of these assumptions, which are seldom fulfiled in practice in radio astronomy, and treats the full electromagnetic field. To handle wide, partially polarized fields, we extend the two-dimensional (2D) electric field (Jones vector) formalism of the standard `Measurement Equation' (ME) of radio astronomical interferometry to the full three-dimensional (3D) formalism developed in optical coherence theory. The resulting vC-Z theorem enables full-sky imaging in a single telescope pointing, and imaging based not only on standard dual-polarized interferometers (that measure 2D electric fields) but also electric tripoles and electromagnetic vector-sensor interferometers. We show that the standard 2D ME is easily obtained from our formalism in the case of dual-polarized antenna element interferometers. We also exploit an extended 2D ME to determine that dual-polarized interferometers can have polarimetric aberrations at the edges of a wide FoV. Our vC-Z theorem is particularly relevant to proposed, and recently developed, wide FoV interferometers such as Low Frequency Array (LOFAR) and Square Kilometer Array (SKA), for which direction-dependent effects will be important.

An Image Retrieval and Processing Expert System for the World Wide Web

Science.gov (United States)

Rodriguez, Ricardo; Rondon, Angelica; Bruno, Maria I.; Vasquez, Ramon

1998-01-01

This paper presents a system that is being developed in the Laboratory of Applied Remote Sensing and Image Processing at the University of P.R. at Mayaguez. It describes the components that constitute its architecture. The main elements are: a Data Warehouse, an Image Processing Engine, and an Expert System. Together, they provide a complete solution to researchers from different fields that make use of images in their investigations. Also, since it is available to the World Wide Web, it provides remote access and processing of images.

Contact-free trans-pars-planar illumination enables snapshot fundus camera for nonmydriatic wide field photography.

Science.gov (United States)

Wang, Benquan; Toslak, Devrim; Alam, Minhaj Nur; Chan, R V Paul; Yao, Xincheng

2018-06-08

In conventional fundus photography, trans-pupillary illumination delivers illuminating light to the interior of the eye through the peripheral area of the pupil, and only the central part of the pupil can be used for collecting imaging light. Therefore, the field of view of conventional fundus cameras is limited, and pupil dilation is required for evaluating the retinal periphery which is frequently affected by diabetic retinopathy (DR), retinopathy of prematurity (ROP), and other chorioretinal conditions. We report here a nonmydriatic wide field fundus camera employing trans-pars-planar illumination which delivers illuminating light through the pars plana, an area outside of the pupil. Trans-pars-planar illumination frees the entire pupil for imaging purpose only, and thus wide field fundus photography can be readily achieved with less pupil dilation. For proof-of-concept testing, using all off-the-shelf components a prototype instrument that can achieve 90° fundus view coverage in single-shot fundus images, without the need of pharmacologic pupil dilation was demonstrated.

Electrolocation-based underwater obstacle avoidance using wide-field integration methods

International Nuclear Information System (INIS)

Dimble, Kedar D; Faddy, James M; Humbert, J Sean

2014-01-01

Weakly electric fish are capable of efficiently performing obstacle avoidance in dark and navigationally challenging aquatic environments using electrosensory information. This sensory modality enables extraction of relevant proximity information about surrounding obstacles by interpretation of perturbations induced to the fish’s self-generated electric field. In this paper, reflexive obstacle avoidance is demonstrated by extracting relative proximity information using spatial decompositions of the perturbation signal, also called an electric image. Electrostatics equations were formulated for mathematically expressing electric images due to a straight tunnel to the electric field generated with a planar electro-sensor model. These equations were further used to design a wide-field integration based static output feedback controller. The controller was implemented in quasi-static simulations for environments with complicated geometries modelled using finite element methods to demonstrate sense and avoid behaviours. The simulation results were confirmed by performing experiments using a computer operated gantry system in environments lined with either conductive or non-conductive objects acting as global stimuli to the field of the electro-sensor. The proposed approach is computationally inexpensive and readily implementable, making underwater autonomous navigation in real-time feasible. (paper)

Reconsidering the advantages of the three-dimensional representation of the interferometric transform for imaging with non-coplanar baselines and wide fields of view

Science.gov (United States)

Smith, D. M. P.; Young, A.; Davidson, D. B.

2017-07-01

Radio telescopes with baselines that span thousands of kilometres and with fields of view that span tens of degrees have been recently deployed, such as the Low Frequency Array, and are currently being developed, such as the Square Kilometre Array. Additionally, there are proposals for space-based instruments with all-sky imaging capabilities, such as the Orbiting Low Frequency Array. Such telescopes produce observations with three-dimensional visibility distributions and curved image domains. In most work to date, the visibility distribution has been converted to a planar form to compute the brightness map using a two-dimensional Fourier transform. The celestial sphere is faceted in order to counter pixel distortion at wide angles, with each such facet requiring a unique planar form of the visibility distribution. Under the above conditions, the computational and storage complexities of this approach can become excessive. On the other hand, when using the direct Fourier transform approach, which maintains the three-dimensional shapes of the visibility distribution and celestial sphere, the non-coplanar visibility component requires no special attention. Furthermore, as the celestial samples are placed directly on the curved surface of the celestial sphere, pixel distortion at wide angles is avoided. In this paper, a number of examples illustrate that under these conditions (very long baselines and very wide fields of view) the costs of the direct Fourier transform may be comparable to (or even lower than) methods that utilise the two-dimensional fast Fourier transform.

Compact plane illumination plugin device to enable light sheet fluorescence imaging of multi-cellular organisms on an inverted wide-field microscope.

Science.gov (United States)

Guan, Zeyi; Lee, Juhyun; Jiang, Hao; Dong, Siyan; Jen, Nelson; Hsiai, Tzung; Ho, Chih-Ming; Fei, Peng

2016-01-01

We developed a compact plane illumination plugin (PIP) device which enabled plane illumination and light sheet fluorescence imaging on a conventional inverted microscope. The PIP device allowed the integration of microscope with tunable laser sheet profile, fast image acquisition, and 3-D scanning. The device is both compact, measuring approximately 15 by 5 by 5 cm, and cost-effective, since we employed consumer electronics and an inexpensive device molding method. We demonstrated that PIP provided significant contrast and resolution enhancement to conventional microscopy through imaging different multi-cellular fluorescent structures, including 3-D branched cells in vitro and live zebrafish embryos. Imaging with the integration of PIP greatly reduced out-of-focus contamination and generated sharper contrast in acquired 2-D plane images when compared with the stand-alone inverted microscope. As a result, the dynamic fluid domain of the beating zebrafish heart was clearly segmented and the functional monitoring of the heart was achieved. Furthermore, the enhanced axial resolution established by thin plane illumination of PIP enabled the 3-D reconstruction of the branched cellular structures, which leads to the improvement on the functionality of the wide field microscopy.

Optical design of a Michelson wide-field multiple-aperture telescope

Science.gov (United States)

Cassaing, Frederic; Sorrente, Beatrice; Fleury, Bruno; Laubier, David

2004-02-01

Multiple-Aperture Optical Telescopes (MAOTs) are a promising solution for very high resolution imaging. In the Michelson configuration, the instrument is made of sub-telescopes distributed in the pupil and combined by a common telescope via folding periscopes. The phasing conditions of the sub-pupils lead to specific optical constraints in these subsystems. The amplitude of main contributors to the wavefront error (WFE) is given as a function of high level requirements (such as field or resolution) and free parameters, mainly the sub-telescope type, magnification and diameter. It is shown that for the periscopes, the field-to-resolution ratio is the main design driver and can lead to severe specifications. The effect of sub-telescopes aberrations on the global WFE can be minimized by reducing their diameter. An analytical tool for the MAOT design has been derived from this analysis, illustrated and validated in three different cases: LEO or GEO Earth observation and astronomy with extremely large telescopes. The last two cases show that a field larger than 10 000 resolution elements can be covered with a very simple MAOT based on Mersenne paraboloid-paraboloid sub-telescopes. Michelson MAOTs are thus a solution to be considered for high resolution wide-field imaging, from space or ground.

Challenges and advantages in wide-field optical coherence tomography angiography imaging of the human retinal and choroidal vasculature at 1.7-MHz A-scan rate

Science.gov (United States)

Poddar, Raju; Migacz, Justin V.; Schwartz, Daniel M.; Werner, John S.; Gorczynska, Iwona

2017-10-01

We present noninvasive, three-dimensional, depth-resolved imaging of human retinal and choroidal blood circulation with a swept-source optical coherence tomography (OCT) system at 1065-nm center wavelength. Motion contrast OCT imaging was performed with the phase-variance OCT angiography method. A Fourier-domain mode-locked light source was used to enable an imaging rate of 1.7 MHz. We experimentally demonstrate the challenges and advantages of wide-field OCT angiography (OCTA). In the discussion, we consider acquisition time, scanning area, scanning density, and their influence on visualization of selected features of the retinal and choroidal vascular networks. The OCTA imaging was performed with a field of view of 16 deg (5 mm×5 mm) and 30 deg (9 mm×9 mm). Data were presented in en face projections generated from single volumes and in en face projection mosaics generated from up to 4 datasets. OCTA imaging at 1.7 MHz A-scan rate was compared with results obtained from a commercial OCTA instrument and with conventional ophthalmic diagnostic methods: fundus photography, fluorescein, and indocyanine green angiography. Comparison of images obtained from all methods is demonstrated using the same eye of a healthy volunteer. For example, imaging of retinal pathology is presented in three cases of advanced age-related macular degeneration.

Flight performance of an advanced CZT imaging detector in a balloon-borne wide-field hard X-ray telescope-ProtoEXIST1

Energy Technology Data Exchange (ETDEWEB)

Hong, J., E-mail: jaesub@head.cfa.harvard.edu [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Allen, B.; Grindlay, J. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Barthelemy, S.; Baker, R. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Garson, A.; Krawczynski, H. [Washington University in St. Louis and the McDonnell Center for the Space Sciences, St. Louis, MO 63130 (United States); Apple, J.; Cleveland, W.H. [NASA Marshall Space Flight Center and Universities Space Research Association, Huntsville, AL 35812 (United States)

2011-10-21

We successfully carried out the first high-altitude balloon flight of a wide-field hard X-ray coded-aperture telescope ProtoEXIST1, which was launched from the Columbia Scientific Balloon Facility at Ft. Sumner, New Mexico on October 9, 2009. ProtoEXIST1 is the first implementation of an advanced CdZnTe (CZT) imaging detector in our ongoing program to establish the technology required for next generation wide-field hard X-ray telescopes such as the High Energy Telescope (HET) in the Energetic X-ray Imaging Survey Telescope (EXIST). The CZT detector plane in ProtoEXIST1 consists of an 8x8 array of closely tiled 2 cmx2 cmx0.5 cm thick pixellated CZT crystals, each with 8x8 pixels, mounted on a set of readout electronics boards and covering a 256 cm{sup 2} active area with 2.5 mm pixels. A tungsten mask, mounted at 90 cm above the detector provides shadowgrams of X-ray sources in the 30-600 keV band for imaging, allowing a fully coded field of view of 9{sup o}x9{sup o} (and 19{sup o}x19{sup o} for 50% coding fraction) with an angular resolution of 20'. In order to reduce the background radiation, the detector is surrounded by semi-graded (Pb/Sn/Cu) passive shields on the four sides all the way to the mask. On the back side, a 26 cmx26 cmx2 cm CsI(Na) active shield provides signals to tag charged particle induced events as well as {>=}100keV background photons from below. The flight duration was only about 7.5 h due to strong winds (60 knots) at float altitude (38-39 km). Throughout the flight, the CZT detector performed excellently. The telescope observed Cyg X-1, a bright black hole binary system, for {approx}1h at the end of the flight. Despite a few problems with the pointing and aspect systems that caused the telescope to track about 6.4{sup o} off the target, the analysis of the Cyg X-1 data revealed an X-ray source at 7.2{sigma} in the 30-100 keV energy band at the expected location from the optical images taken by the onboard daytime star camera. The

Optical system design with wide field of view and high resolution based on monocentric multi-scale construction

Science.gov (United States)

Wang, Fang; Wang, Hu; Xiao, Nan; Shen, Yang; Xue, Yaoke

2018-03-01

With the development of related technology gradually mature in the field of optoelectronic information, it is a great demand to design an optical system with high resolution and wide field of view(FOV). However, as it is illustrated in conventional Applied Optics, there is a contradiction between these two characteristics. Namely, the FOV and imaging resolution are limited by each other. Here, based on the study of typical wide-FOV optical system design, we propose the monocentric multi-scale system design method to solve this problem. Consisting of a concentric spherical lens and a series of micro-lens array, this system has effective improvement on its imaging quality. As an example, we designed a typical imaging system, which has a focal length of 35mm and a instantaneous field angle of 14.7", as well as the FOV set to be 120°. By analyzing the imaging quality, we demonstrate that in different FOV, all the values of MTF at 200lp/mm are higher than 0.4 when the sampling frequency of the Nyquist is 200lp/mm, which shows a good accordance with our design.

Wide Field Infra-Red Survey Telescope (WFIRST) 2.4-Meter Mission Study

Science.gov (United States)

Content, D.; Aaron, K.; Alplanalp, L.; Anderson, K.; Capps, R.; Chang, Z.; Dooley, J.; Egerman, R.; Goullioud, R.; Klein, D.;

Near-field three-dimensional radar imaging techniques and applications.

Science.gov (United States)

Sheen, David; McMakin, Douglas; Hall, Thomas

2010-07-01

Three-dimensional radio frequency imaging techniques have been developed for a variety of near-field applications, including radar cross-section imaging, concealed weapon detection, ground penetrating radar imaging, through-barrier imaging, and nondestructive evaluation. These methods employ active radar transceivers that operate at various frequency ranges covering a wide range, from less than 100 MHz to in excess of 350 GHz, with the frequency range customized for each application. Computational wavefront reconstruction imaging techniques have been developed that optimize the resolution and illumination quality of the images. In this paper, rectilinear and cylindrical three-dimensional imaging techniques are described along with several application results.

Wide field of view common-path lateral-shearing digital holographic interference microscope.

Science.gov (United States)

Vora, Priyanka; Trivedi, Vismay; Mahajan, Swapnil; Patel, Nimit; Joglekar, Mugdha; Chhaniwal, Vani; Moradi, Ali-Reza; Javidi, Bahram; Anand, Arun

2017-12-01

Quantitative three-dimensional (3-D) imaging of living cells provides important information about the cell morphology and its time variation. Off-axis, digital holographic interference microscopy is an ideal tool for 3-D imaging, parameter extraction, and classification of living cells. Two-beam digital holographic microscopes, which are usually employed, provide high-quality 3-D images of micro-objects, albeit with lower temporal stability. Common-path digital holographic geometries, in which the reference beam is derived from the object beam, provide higher temporal stability along with high-quality 3-D images. Self-referencing geometry is the simplest of the common-path techniques, in which a portion of the object beam itself acts as the reference, leading to compact setups using fewer optical elements. However, it has reduced field of view, and the reference may contain object information. Here, we describe the development of a common-path digital holographic microscope, employing a shearing plate and converting one of the beams into a separate reference by employing a pin-hole. The setup is as compact as self-referencing geometry, while providing field of view as wide as that of a two-beam microscope. The microscope is tested by imaging and quantifying the morphology and dynamics of human erythrocytes. (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).

Low drive field amplitude for improved image resolution in magnetic particle imaging.

Science.gov (United States)

Croft, Laura R; Goodwill, Patrick W; Konkle, Justin J; Arami, Hamed; Price, Daniel A; Li, Ada X; Saritas, Emine U; Conolly, Steven M

2016-01-01

Magnetic particle imaging (MPI) is a new imaging technology that directly detects superparamagnetic iron oxide nanoparticles. The technique has potential medical applications in angiography, cell tracking, and cancer detection. In this paper, the authors explore how nanoparticle relaxation affects image resolution. Historically, researchers have analyzed nanoparticle behavior by studying the time constant of the nanoparticle physical rotation. In contrast, in this paper, the authors focus instead on how the time constant of nanoparticle rotation affects the final image resolution, and this reveals nonobvious conclusions for tailoring MPI imaging parameters for optimal spatial resolution. The authors first extend x-space systems theory to include nanoparticle relaxation. The authors then measure the spatial resolution and relative signal levels in an MPI relaxometer and a 3D MPI imager at multiple drive field amplitudes and frequencies. Finally, these image measurements are used to estimate relaxation times and nanoparticle phase lags. The authors demonstrate that spatial resolution, as measured by full-width at half-maximum, improves at lower drive field amplitudes. The authors further determine that relaxation in MPI can be approximated as a frequency-independent phase lag. These results enable the authors to accurately predict MPI resolution and sensitivity across a wide range of drive field amplitudes and frequencies. To balance resolution, signal-to-noise ratio, specific absorption rate, and magnetostimulation requirements, the drive field can be a low amplitude and high frequency. Continued research into how the MPI drive field affects relaxation and its adverse effects will be crucial for developing new nanoparticles tailored to the unique physics of MPI. Moreover, this theory informs researchers how to design scanning sequences to minimize relaxation-induced blurring for better spatial resolution or to exploit relaxation-induced blurring for MPI with

Two wide-angle imaging neutral-atom spectrometers

Energy Technology Data Exchange (ETDEWEB)

McComas, D.J.

1997-12-31

The Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) mission provides a new capability for stereoscopically imaging the magnetosphere. By imaging the charge exchange neutral atoms over a broad energy range (1 < E , {approximately} 100 keV) using two identical instruments on two widely-spaced high-altitude, high-inclination spacecraft, TWINS will enable the 3-dimensional visualization and the resolution of large scale structures and dynamics within the magnetosphere for the first time. These observations will provide a leap ahead in the understanding of the global aspects of the terrestrial magnetosphere and directly address a number of critical issues in the ``Sun-Earth Connections`` science theme of the NASA Office of Space Science.

Two wide-angle imaging neutral-atom spectrometers

International Nuclear Information System (INIS)

McComas, D.J.

1997-01-01

The Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) mission provides a new capability for stereoscopically imaging the magnetosphere. By imaging the charge exchange neutral atoms over a broad energy range (1 < E , ∼ 100 keV) using two identical instruments on two widely-spaced high-altitude, high-inclination spacecraft, TWINS will enable the 3-dimensional visualization and the resolution of large scale structures and dynamics within the magnetosphere for the first time. These observations will provide a leap ahead in the understanding of the global aspects of the terrestrial magnetosphere and directly address a number of critical issues in the ''Sun-Earth Connections'' science theme of the NASA Office of Space Science

Three-dimensional imaging in degraded visual field

International Nuclear Information System (INIS)

Oran, A.; Ozdur, I.; Ozharar, S.

2016-01-01

Imaging at degraded visual environments is one of the biggest challenges in today’s imaging technologies. Especially military and commercial rotary wing aviation is suffering from impaired visual field in sandy, dusty, marine and snowy environments. For example during landing the rotor churns up the particles and creates dense clouds of highly scattering medium, which limits the vision of the pilot and may result in an uncontrolled landing. The vision in such environments is limited because of the high ratio of scattered photons over the ballistic photons which have the image information. We propose to use optical spatial filtering (OSF) method in order to eliminate the scattered photons and only collect the ballistic photons at the receiver. OSF is widely used in microscopy, to the best of our knowledge this will be the first application of OSF for macroscopic imaging. Our experimental results show that most of the scattered photons are eliminated using the spatial filtering in a highly scattering impaired visual field. The results are compared with a standard broad area photo detector which shows the effectiveness of spatial filtering. (paper)

Near-field acoustic imaging based on Laplacian sparsity

DEFF Research Database (Denmark)

Fernandez Grande, Efren; Daudet, Laurent

2016-01-01

We present a sound source identification method for near-field acoustic imaging of extended sources. The methodology is based on a wave superposition method (or equivalent source method) that promotes solutions with sparse higher order spatial derivatives. Instead of promoting direct sparsity......, and the validity of the wave extrapolation used for the reconstruction is examined. It is shown that this methodology can overcome conventional limits of spatial sampling, and is therefore valid for wide-band acoustic imaging of extended sources....

Wide-field synovial fluid imaging using polarized lens-free on-chip microscopy for point-of-care diagnostics of gout (Conference Presentation)

Science.gov (United States)

Zhang, Yibo; Lee, Seung Yoon; Zhang, Yun; Furst, Daniel; Fitzgerald, John; Ozcan, Aydogan

2016-03-01

Gout and pseudogout are forms of crystal arthropathy caused by monosodium urate (MSU) and calcium pyrophosphate dehydrate (CPPD) crystals in the joint, respectively, that can result in painful joints. Detecting the unique-shaped, birefringent MSU/CPPD crystals in a synovial fluid sample using a compensated polarizing microscope has been the gold-standard for diagnosis since the 1960's. However, this can be time-consuming and inaccurate, especially if there are only few crystals in the fluid. The high-cost and bulkiness of conventional microscopes can also be limiting for point-of-care diagnosis. Lens-free on-chip microscopy based on digital holography routinely achieves high-throughput and high-resolution imaging in a cost-effective and field-portable design. Here we demonstrate, for the first time, polarized lens-free on-chip imaging of MSU and CPPD crystals over a wide field-of-view (FOV ~ 20.5 mm2, i.e., gout and pseudogout. Circularly polarizer partially-coherent light is used to illuminate the synovial fluid sample on a glass slide, after which a quarter-wave-plate and an angle-mismatched linear polarizer are used to analyze the transmitted light. Two lens-free holograms of the MSU/CPPD sample are taken, with the sample rotated by 90°, to rule out any non-birefringent objects within the specimen. A phase-recovery algorithm is also used to improve the reconstruction quality, and digital pseudo-coloring is utilized to match the color and contrast of the lens-free image to that of a gold-standard microscope image to ease the examination by a rheumatologist or a laboratory technician, and to facilitate computerized analysis.

Invited Article: First flight in space of a wide-field-of-view soft x-ray imager using lobster-eye optics: Instrument description and initial flight results.

Science.gov (United States)

Collier, Michael R; Porter, F Scott; Sibeck, David G; Carter, Jenny A; Chiao, Meng P; Chornay, Dennis J; Cravens, Thomas E; Galeazzi, Massimiliano; Keller, John W; Koutroumpa, Dimitra; Kujawski, Joseph; Kuntz, Kip; Read, Andy M; Robertson, Ina P; Sembay, Steve; Snowden, Steven L; Thomas, Nicholas; Uprety, Youaraj; Walsh, Brian M

2015-07-01

We describe the development, launch into space, and initial results from a prototype wide field-of-view soft X-ray imager that employs lobster-eye optics and targets heliophysics, planetary, and astrophysics science. The sheath transport observer for the redistribution of mass is the first instrument using this type of optics launched into space and provides proof-of-concept for future flight instruments capable of imaging structures such as the terrestrial cusp, the entire dayside magnetosheath from outside the magnetosphere, comets, the Moon, and the solar wind interaction with planetary bodies like Venus and Mars [Kuntz et al., Astrophys. J. (in press)].

Integration of digital gross pathology images for enterprise-wide access

Directory of Open Access Journals (Sweden)

Milon Amin

2012-01-01

Full Text Available Background: Sharing digital pathology images for enterprise- wide use into a picture archiving and communication system (PACS is not yet widely adopted. We share our solution and 3-year experience of transmitting such images to an enterprise image server (EIS. Methods: Gross pathology images acquired by prosectors were integrated with clinical cases into the laboratory information system′s image management module, and stored in JPEG2000 format on a networked image server. Automated daily searches for cases with gross images were used to compile an ASCII text file that was forwarded to a separate institutional Enterprise Digital Imaging and Communications in Medicine (DICOM Wrapper (EDW server. Concurrently, an HL7-based image order for these cases was generated, containing the locations of images and patient data, and forwarded to the EDW, which combined data in these locations to generate images with patient data, as required by DICOM standards. The image and data were then "wrapped" according to DICOM standards, transferred to the PACS servers, and made accessible on an institution-wide basis. Results: In total, 26,966 gross images from 9,733 cases were transmitted over the 3-year period from the laboratory information system to the EIS. The average process time for cases with successful automatic uploads (n=9,688 to the EIS was 98 seconds. Only 45 cases (0.5% failed requiring manual intervention. Uploaded images were immediately available to institution- wide PACS users. Since inception, user feedback has been positive. Conclusions: Enterprise- wide PACS- based sharing of pathology images is feasible, provides useful services to clinical staff, and utilizes existing information system and telecommunications infrastructure. PACS-shared pathology images, however, require a "DICOM wrapper" for multisystem compatibility.

Efficient Terahertz Wide-Angle NUFFT-Based Inverse Synthetic Aperture Imaging Considering Spherical Wavefront

Directory of Open Access Journals (Sweden)

Jingkun Gao

2016-12-01

Full Text Available An efficient wide-angle inverse synthetic aperture imaging method considering the spherical wavefront effects and suitable for the terahertz band is presented. Firstly, the echo signal model under spherical wave assumption is established, and the detailed wavefront curvature compensation method accelerated by 1D fast Fourier transform (FFT is discussed. Then, to speed up the reconstruction procedure, the fast Gaussian gridding (FGG-based nonuniform FFT (NUFFT is employed to focus the image. Finally, proof-of-principle experiments are carried out and the results are compared with the ones obtained by the convolution back-projection (CBP algorithm. The results demonstrate the effectiveness and the efficiency of the presented method. This imaging method can be directly used in the field of nondestructive detection and can also be used to provide a solution for the calculation of the far-field RCSs (Radar Cross Section of targets in the terahertz regime.

Wide-field two-photon microscopy with temporal focusing and HiLo background rejection

Science.gov (United States)

Yew, Elijah Y. S.; Choi, Heejin; Kim, Daekeun; So, Peter T. C.

2011-03-01

Scanningless depth-resolved microscopy is achieved through spatial-temporal focusing and has been demonstrated previously. The advantage of this method is that a large area may be imaged without scanning resulting in higher throughput of the imaging system. Because it is a widefield technique, the optical sectioning effect is considerably poorer than with conventional spatial focusing two-photon microscopy. Here we propose wide-field two-photon microscopy based on spatio-temporal focusing and employing background rejection based on the HiLo microscope principle. We demonstrate the effects of applying HiLo microscopy to widefield temporally focused two-photon microscopy.

New Subarray Readout Patterns for the ACS Wide Field Channel

Science.gov (United States)

Golimowski, D.; Anderson, J.; Arslanian, S.; Chiaberge, M.; Grogin, N.; Lim, Pey Lian; Lupie, O.; McMaster, M.; Reinhart, M.; Schiffer, F.; Serrano, B.; Van Marshall, M.; Welty, A.

2017-04-01

At the start of Cycle 24, the original CCD-readout timing patterns used to generate ACS Wide Field Channel (WFC) subarray images were replaced with new patterns adapted from the four-quadrant readout pattern used to generate full-frame WFC images. The primary motivation for this replacement was a substantial reduction of observatory and staff resources needed to support WFC subarray bias calibration, which became a new and challenging obligation after the installation of the ACS CCD Electronics Box Replacement during Servicing Mission 4. The new readout patterns also improve the overall efficiency of observing with WFC subarrays and enable the processing of subarray images through stages of the ACS data calibration pipeline (calacs) that were previously restricted to full-frame WFC images. The new readout patterns replace the original 512×512, 1024×1024, and 2048×2046-pixel subarrays with subarrays having 2048 columns and 512, 1024, and 2048 rows, respectively. Whereas the original square subarrays were limited to certain WFC quadrants, the new rectangular subarrays are available in all four quadrants. The underlying bias structure of the new subarrays now conforms with those of the corresponding regions of the full-frame image, which allows raw frames in all image formats to be calibrated using one contemporaneous full-frame "superbias" reference image. The original subarrays remain available for scientific use, but calibration of these image formats is no longer supported by STScI.

A Wide Spectral Range Reflectance and Luminescence Imaging System

Directory of Open Access Journals (Sweden)

Tapani Hirvonen

2013-10-01

Full Text Available In this study, we introduce a wide spectral range (200–2500 nm imaging system with a 250 μm minimum spatial resolution, which can be freely modified for a wide range of resolutions and measurement geometries. The system has been tested for reflectance and luminescence measurements, but can also be customized for transmittance measurements. This study includes the performance results of the developed system, as well as examples of spectral images. Discussion of the system relates it to existing systems and methods. The wide range spectral imaging system that has been developed is however highly customizable and has great potential in many practical applications.

The Brazilian wide field imaging camera (WFI) for the China/Brazil earth resources satellite: CBERS 3 and 4

Science.gov (United States)

Scaduto, L. C. N.; Carvalho, E. G.; Modugno, R. G.; Cartolano, R.; Evangelista, S. H.; Segoria, D.; Santos, A. G.; Stefani, M. A.; Castro Neto, J. C.

2017-11-01

The purpose of this paper is to present the optical system developed for the Wide Field imaging Camera - WFI that will be integrated to the CBERS 3 and 4 satellites (China Brazil Earth resources Satellite). This camera will be used for remote sensing of the Earth and it is aimed to work at an altitude of 778 km. The optical system is designed for four spectral bands covering the range of wavelengths from blue to near infrared and its field of view is +/-28.63°, which covers 866 km, with a ground resolution of 64 m at nadir. WFI has been developed through a consortium formed by Opto Electrônica S. A. and Equatorial Sistemas. In particular, we will present the optical analysis based on the Modulation Transfer Function (MTF) obtained during the Engineering Model phase (EM) and the optical tests performed to evaluate the requirements. Measurements of the optical system MTF have been performed using an interferometer at the wavelength of 632.8nm and global MTF tests (including the CCD and signal processing electronic) have been performed by using a collimator with a slit target. The obtained results showed that the performance of the optical system meets the requirements of project.

Advanced Wide-Field Interferometric Microscopy for Nanoparticle Sensing and Characterization

Science.gov (United States)

Avci, Oguzhan

Nanoparticles have a key role in today's biotechnological research owing to the rapid advancement of nanotechnology. While metallic, polymer, and semiconductor based artificial nanoparticles are widely used as labels or targeted drug delivery agents, labeled and label-free detection of natural nanoparticles promise new ways for viral diagnostics and therapeutic applications. The increasing impact of nanoparticles in bio- and nano-technology necessitates the development of advanced tools for their accurate detection and characterization. Optical microscopy techniques have been an essential part of research for visualizing micron-scale particles. However, when it comes to the visualization of individual nano-scale particles, they have shown inadequate success due to the resolution and visibility limitations. Interferometric microscopy techniques have gained significant attention for providing means to overcome the nanoparticle visibility issue that is often the limiting factor in the imaging techniques based solely on the scattered light. In this dissertation, we develop a rigorous physical model to simulate the single nanoparticle optical response in a common-path wide-field interferometric microscopy (WIM) system. While the fundamental elements of the model can be used to analyze nanoparticle response in any generic wide-field imaging systems, we focus on imaging with a layered substrate (common-path interferometer) where specular reflection of illumination provides the reference light for interferometry. A robust physical model is quintessential in realizing the full potential of an optical system, and throughout this dissertation, we make use of it to benchmark our experimental findings, investigate the utility of various optical configurations, reconstruct weakly scattering nanoparticle images, as well as to characterize and discriminate interferometric nanoparticle responses. This study investigates the integration of advanced optical schemes in WIM with two

SUPERNOVA REMNANTS AND THE INTERSTELLAR MEDIUM OF M83: IMAGING AND PHOTOMETRY WITH THE WIDE FIELD CAMERA 3 ON THE HUBBLE SPACE TELESCOPE

International Nuclear Information System (INIS)

Dopita, Michael A.; Blair, William P.; Kuntz, Kip D.; Long, Knox S.; Mutchler, Max; Whitmore, Bradley C.; Bond, Howard E.; MacKenty, John; Balick, Bruce; Calzetti, Daniela; Carollo, Marcella; Disney, Michael; Frogel, Jay A.; O'Connell, Robert; Hall, Donald; Holtzman, Jon A.; Kimble, Randy A.; McCarthy, Patrick; Paresce, Francesco; Saha, Abhijit

2010-01-01

We present Wide Field Camera 3 images taken with the Hubble Space Telescope within a single field in the southern grand design star-forming galaxy M83. Based on their size, morphology, and photometry in continuum-subtracted Hα, [S II], Hβ, [O III], and [O II] filters, we have identified 60 supernova remnant (SNR) candidates, as well as a handful of young ejecta-dominated candidates. A catalog of these remnants, their sizes and, where possible, their Hα fluxes are given. Radiative ages and pre-shock densities are derived from those SNRs that have good photometry. The ages lie in the range 2.62 rad /yr) 0 /cm -3 min = 16 +7 -5 M sun . Finally, we give evidence for the likely detection of the remnant of the historical supernova, SN1968L.

Wide Area Wind Field Monitoring Status & Results

Energy Technology Data Exchange (ETDEWEB)

Alan Marchant; Jed Simmons

2011-09-30

Volume-scanning elastic has been investigated as a means to derive 3D dynamic wind fields for characterization and monitoring of wind energy sites. An eye-safe volume-scanning lidar system was adapted for volume imaging of aerosol concentrations out to a range of 300m. Reformatting of the lidar data as dynamic volume images was successfully demonstrated. A practical method for deriving 3D wind fields from dynamic volume imagery was identified and demonstrated. However, the natural phenomenology was found to provide insufficient aerosol features for reliable wind sensing. The results of this study may be applicable to wind field measurement using injected aerosol tracers.

ISS-Lobster: A Proposed Wide-Field X-Ray Telescope on the International Space Station

Science.gov (United States)

Camp, Jordan

2012-01-01

The Lobster wide-field imaging telescope combines simultaneous high FOV, high sensitivity and good position resolution. These characteristics can open the field of X-Ray time domain astronomy, which will study many interesting transient sources, including tidal disruptions of stars, supernova shock breakouts, and high redshift gamma-ray bursts. Also important will be its use for the X-ray follow-up of gravitational wave detections. I will describe our present effort to propose the Lobster concept for deployment on the International Space Station through a NASA Mission of Opportunity this fall.

Developing Wide-Field Spatio-Spectral Interferometry for Far-Infrared Space Applications

Science.gov (United States)

Leisawitz, David; Bolcar, Matthew R.; Lyon, Richard G.; Maher, Stephen F.; Memarsadeghi, Nargess; Rinehart, Stephen A.; Sinukoff, Evan J.

2012-01-01

Interferometry is an affordable way to bring the benefits of high resolution to space far-IR astrophysics. We summarize an ongoing effort to develop and learn the practical limitations of an interferometric technique that will enable the acquisition of high-resolution far-IR integral field spectroscopic data with a single instrument in a future space-based interferometer. This technique was central to the Space Infrared Interferometric Telescope (SPIRIT) and Submillimeter Probe of the Evolution of Cosmic Structure (SPECS) space mission design concepts, and it will first be used on the Balloon Experimental Twin Telescope for Infrared Interferometry (BETTII). Our experimental approach combines data from a laboratory optical interferometer (the Wide-field Imaging Interferometry Testbed, WIIT), computational optical system modeling, and spatio-spectral synthesis algorithm development. We summarize recent experimental results and future plans.

Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo

Science.gov (United States)

Liang, Kaicheng; Wang, Zhao; Ahsen, Osman O.; Lee, Hsiang-Chieh; Potsaid, Benjamin M.; Jayaraman, Vijaysekhar; Cable, Alex; Mashimo, Hiroshi; Li, Xingde; Fujimoto, James G.

2018-01-01

Devices that perform wide field-of-view (FOV) precision optical scanning are important for endoscopic assessment and diagnosis of luminal organ disease such as in gastroenterology. Optical scanning for in vivo endoscopic imaging has traditionally relied on one or more proximal mechanical actuators, limiting scan accuracy and imaging speed. There is a need for rapid and precise two-dimensional (2D) microscanning technologies to enable the translation of benchtop scanning microscopies to in vivo endoscopic imaging. We demonstrate a new cycloid scanner in a tethered capsule for ultrahigh speed, side-viewing optical coherence tomography (OCT) endomicroscopy in vivo. The cycloid capsule incorporates two scanners: a piezoelectrically actuated resonant fiber scanner to perform a precision, small FOV, fast scan and a micromotor scanner to perform a wide FOV, slow scan. Together these scanners distally scan the beam circumferentially in a 2D cycloid pattern, generating an unwrapped 1 mm × 38 mm strip FOV. Sequential strip volumes can be acquired with proximal pullback to image centimeter-long regions. Using ultrahigh speed 1.3 μm wavelength swept-source OCT at a 1.17 MHz axial scan rate, we imaged the human rectum at 3 volumes/s. Each OCT strip volume had 166 × 2322 axial scans with 8.5 μm axial and 30 μm transverse resolution. We further demonstrate OCT angiography at 0.5 volumes/s, producing volumetric images of vasculature. In addition to OCT applications, cycloid scanning promises to enable precision 2D optical scanning for other imaging modalities, including fluorescence confocal and nonlinear microscopy. PMID:29682598

Stellar photometry with the Wide Field/Planetary Camera of the Hubble Space Telescope

International Nuclear Information System (INIS)

Holtzman, J.A.

1990-01-01

Simulations of Wide Field/Planetary Camera (WF/PC) images are analyzed in order to discover the most effective techniques for stellar photometry and to evaluate the accuracy and limitations of these techniques. The capabilities and operation of the WF/PC and the simulations employed in the study are described. The basic techniques of stellar photometry and methods to improve these techniques for the WF/PC are discussed. The correct parameters for star detection, aperture photometry, and point-spread function (PSF) fitting with the DAOPHOT software of Stetson (1987) are determined. Consideration is given to undersampling of the stellar images by the detector; variations in the PSF; and the crowding of the stellar images. It is noted that, with some changes DAOPHOT, is able to generate photometry almost to the level of photon statistics. 10 refs

KMTNET: A Network of 1.6 m Wide-Field Optical Telescopes Installed at Three Southern Observatories

Science.gov (United States)

Kim, Seung-Lee; Lee, Chung-Uk; Park, Byeong-Gon; Kim, Dong-Jin; Cha, Sang-Mok; Lee, Yongseok; Han, Cheongho; Chun, Moo-Young; Yuk, Insoo

2016-02-01

The Korea Microlensing Telescope Network (KMTNet) is a wide-field photometric system installed by the Korea Astronomy and Space Science Institute (KASI). Here, we present the overall technical specifications of the KMTNet observation system, test observation results, data transfer and image processing procedure, and finally, the KMTNet science programs. The system consists of three 1.6 m wide-field optical telescopes equipped with mosaic CCD cameras of 18k by 18k pixels. Each telescope provides a 2.0 by 2.0 square degree field of view. We have finished installing all three telescopes and cameras sequentially at the Cerro-Tololo Inter-American Observatory (CTIO) in Chile, the South African Astronomical Observatory (SAAO) in South Africa, and the Siding Spring Observatory (SSO) in Australia. This network of telescopes, which is spread over three different continents at a similar latitude of about -30 degrees, enables 24-hour continuous monitoring of targets observable in the Southern Hemisphere. The test observations showed good image quality that meets the seeing requirement of less than 1.0 arcsec in I-band. All of the observation data are transferred to the KMTNet data center at KASI via the international network communication and are processed with the KMTNet data pipeline. The primary scientific goal of the KMTNet is to discover numerous extrasolar planets toward the Galactic bulge by using the gravitational microlensing technique, especially earth-mass planets in the habitable zone. During the non-bulge season, the system is used for wide-field photometric survey science on supernovae, asteroids, and external galaxies.

Cryogenic solid Schmidt camera as a base for future wide-field IR systems

Science.gov (United States)

Yudin, Alexey N.

2011-11-01

Work is focused on study of capability of solid Schmidt camera to serve as a wide-field infrared lens for aircraft system with whole sphere coverage, working in 8-14 um spectral range, coupled with spherical focal array of megapixel class. Designs of 16 mm f/0.2 lens with 60 and 90 degrees sensor diagonal are presented, their image quality is compared with conventional solid design. Achromatic design with significantly improved performance, containing enclosed soft correcting lens behind protective front lens is proposed. One of the main goals of the work is to estimate benefits from curved detector arrays in 8-14 um spectral range wide-field systems. Coupling of photodetector with solid Schmidt camera by means of frustrated total internal reflection is considered, with corresponding tolerance analysis. The whole lens, except front element, is considered to be cryogenic, with solid Schmidt unit to be flown by hydrogen for improvement of bulk transmission.

Andromeda (M31) optical and infrared disk survey. I. Insights in wide-field near-IR surface photometry

International Nuclear Information System (INIS)

Sick, Jonathan; Courteau, Stéphane; Cuillandre, Jean-Charles; McDonald, Michael; De Jong, Roelof; Tully, R. Brent

2014-01-01

We present wide-field near-infrared J and K s images of the Andromeda Galaxy (M31) taken with WIRCam at the Canada-France-Hawaii Telescope as part of the Andromeda Optical and Infrared Disk Survey. This data set allows simultaneous observations of resolved stars and near-infrared (NIR) surface brightness across M31's entire bulge and disk (within R = 22 kpc), permitting a direct test of the stellar composition of near-infrared light in a nearby galaxy. Here we develop NIR observation and reduction methods to recover a uniform surface brightness map across the 3° × 1° disk of M31 with 27 WIRCam fields. Two sky-target nodding strategies are tested, and we find that strictly minimizing sky sampling latency cannot improve background subtraction accuracy to better than 2% of the background level due to spatio-temporal variations in the NIR skyglow. We fully describe our WIRCam reduction pipeline and advocate using flats built from night-sky images over a single night, rather than dome flats that do not capture the WIRCam illumination field. Contamination from scattered light and thermal background in sky flats has a negligible effect on the surface brightness shape compared to the stochastic differences in background shape between sky and galaxy disk fields, which are ∼0.3% of the background level. The most dramatic calibration step is the introduction of scalar sky offsets to each image that optimizes surface brightness continuity. Sky offsets reduce the mean surface brightness difference between observation blocks from 1% to <0.1% of the background level, though the absolute background level remains statistically uncertain to 0.15% of the background level. We present our WIRCam reduction pipeline and performance analysis to give specific recommendations for the improvement of NIR wide-field imaging methods.

Digital approximation to extended depth of field in no telecentric imaging systems

International Nuclear Information System (INIS)

Meneses, J E; Contreras, C R

2011-01-01

A method used to digitally extend the depth of field of an imaging system consists to move the object of study along the optical axis of the system and different images will contain different areas that are sharp; those images are stored and processed digitally to obtain a fused image, in that image will be sharp all regions of the object. The implementation of this method, although widely used, imposes certain experimental conditions that should be evaluated for to study the degree of validity of the image final obtained. An experimental condition is related with the conservation of the geometric magnification factor when there is a relative movement between the object and the observation system; this implies that the system must be telecentric, which leads to a reduction of the observation field and the use of expensive systems if the application includes microscopic observation. This paper presents a technique that makes possible to extend depth of filed of an imaging system non telecentric; this system is used to realize applications in Optical Metrology with systems that have great observation field.

Radial Peripapillary Capillary Network Visualized Using Wide-Field Montage Optical Coherence Tomography Angiography.

Science.gov (United States)

Mase, Tomoko; Ishibazawa, Akihiro; Nagaoka, Taiji; Yokota, Harumasa; Yoshida, Akitoshi

2016-07-01

We quantitatively analyzed the features of a radial peripapillary capillary (RPC) network visualized using wide-field montage optical coherence tomography (OCT) angiography in healthy human eyes. Twenty eyes of 20 healthy subjects were recruited. En face 3 × 3-mm OCT angiograms of multiple locations in the posterior pole were acquired using the RTVue XR Avanti, and wide-field montage images of the RPC were created. To evaluate the RPC density, the montage images were binarized and skeletonized. The correlation between the RPC density and the retinal nerve fiber layer (RNFL) thickness measured by an OCT circle scan was investigated. The RPC at the temporal retina was detected as far as 7.6 ± 0.7 mm from the edge of the optic disc but not around the perifoveal area within 0.9 ± 0.1 mm of the fovea. Capillary-free zones beside the first branches of the arterioles were significantly (P optic disc edge were 13.6 ± 0.8, 11.9 ± 0.9, and 10.4 ± 0.9 mm-1. The RPC density also was correlated significantly (r = 0.64, P network. The RPC is present in the superficial peripapillary retina in proportion to the RNFL thickness, supporting the idea that the RPC may be the vascular network primarily responsible for RNFL nourishment.

Review The Ooty Wide Field Array

Indian Academy of Sciences (India)

c Indian Academy of Sciences. DOI 10.1007/s12036-017-9430-4. Review. The Ooty Wide Field ... salient features of the upgrade, as well as its main science drivers. There are three ..... tecture for low frequency arrays, Ph.D. thesis, Jawaharalal.

Extracting flat-field images from scene-based image sequences using phase correlation

Energy Technology Data Exchange (ETDEWEB)

Caron, James N., E-mail: Caron@RSImd.com [Research Support Instruments, 4325-B Forbes Boulevard, Lanham, Maryland 20706 (United States); Montes, Marcos J. [Naval Research Laboratory, Code 7231, 4555 Overlook Avenue, SW, Washington, DC 20375 (United States); Obermark, Jerome L. [Naval Research Laboratory, Code 8231, 4555 Overlook Avenue, SW, Washington, DC 20375 (United States)

2016-06-15

Flat-field image processing is an essential step in producing high-quality and radiometrically calibrated images. Flat-fielding corrects for variations in the gain of focal plane array electronics and unequal illumination from the system optics. Typically, a flat-field image is captured by imaging a radiometrically uniform surface. The flat-field image is normalized and removed from the images. There are circumstances, such as with remote sensing, where a flat-field image cannot be acquired in this manner. For these cases, we developed a phase-correlation method that allows the extraction of an effective flat-field image from a sequence of scene-based displaced images. The method uses sub-pixel phase correlation image registration to align the sequence to estimate the static scene. The scene is removed from sequence producing a sequence of misaligned flat-field images. An average flat-field image is derived from the realigned flat-field sequence.

Stray-field-induced Faraday contributions in wide-field Kerr microscopy and -magnetometry

International Nuclear Information System (INIS)

Markó, D.; Soldatov, I.; Tekielak, M.; Schäfer, R.

2015-01-01

The magnetic domain contrast in wide-field Kerr microscopy on bulk specimens can be substantially distorted by non-linear, field-dependent Faraday rotations in the objective lens that are caused by stray-field components emerging from the specimen. These Faraday contributions, which were detected by Kerr-magnetometry on grain-oriented iron–silicon steel samples, are thoroughly elaborated and characterized. They express themselves as a field-dependent gray-scale offset to the domain contrast and in highly distorted surface magnetization curves if optically measured in a wide field Kerr microscope. An experimental method to avoid such distortions is suggested. In the course of these studies, a low-permeability part in the surface magnetization loop of slightly misoriented (110)-surfaces in iron–silicon sheets was discovered that is attributed to demagnetization effects in direction perpendicular to the sheet surface. - Highlights: • Magnetizing a finite sample in a Kerr microscope leads to sample-generated stray-fields. • They cause non-linear, field- and position-dependent Faraday rotations in the objective. • This leads to a modulation of the Kerr contrast and to distorted MOKE loops. • A method to compensate these Faraday rotations is presented

Wide field x-ray telescopes: Detecting x-ray transients/afterglows related to GRBs

International Nuclear Information System (INIS)

Hudec, Rene; Pina, Ladislav; Inneman, Adolf; Gorenstein, Paul

1998-01-01

The recent discovery of X-ray afterglows of GRBs opens the possibility of analyses of GRBs by their X-ray detections. However, imaging X-ray telescopes in current use mostly have limited fields of view. Alternative X-ray optics geometries achieving very large fields of view have been theoretically suggested in the 70's but not constructed and used so far. We review the geometries and basic properties of the wide-field X-ray optical systems based on one- and two-dimensional lobster-eye geometry and suggest technologies for their development and construction. First results of the development of double replicated X-ray reflecting flats for use in one-dimensional X-ray optics of lobster-eye type are presented and discussed. The optimum strategy for locating GRBs upon their X-ray counterparts is also presented and discussed

Neutron Dark-Field Imaging

Science.gov (United States)

Mullins, David

2017-09-01

Neutron imaging is typically used to image and reconstruct objects that are difficult to image using X-Ray imaging techniques. X-Ray absorption is primarily determined by the electron density of the material. This makes it difficult to image objects within materials that have high densities such as metal. However, the neutron scattering cross section primarily depends on the strong nuclear force, which varies somewhat randomly across the periodic table. In this project, an imaging technique known as dark field imaging using a far-field interferometer has been used to study a sample of granite. With this technique, interferometric phase images are generated. The dispersion of the microstructure of the sample dephases the beam, reducing the visibility. Collecting tomographic projections at different autocorrelation lengths (from 100 nanometers to 1.74 micrometers) essentially creates a 3D small angle scattering pattern, enabling mapping of how the microstructure is distributed throughout the sample.

The influence of distrubing effects on the performance of a wide field coded mask X-ray camera

International Nuclear Information System (INIS)

Sims, M.R.; Turner, M.J.L.; Willingale, R.

1985-01-01

The coded aperture telescope, or Dicke camera, is seen as an instrument suitable for many applications in X-ray and gamma ray imaging. In this paper the effects of a partially obscuring window mask support or collimator, a detector with limited spatial resolution, and motion of the camera during image integration are considered using a computer simulation of the performance of such a camera. Cross correlation and the Wiener filter are used to deconvolve the data. It is shown that while these effects cause a degradation in performance this is in no case catastrophic. Deterioration of the image is shown to be greatest where strong sources are present in the field of view and is quite small (proportional 10%) when diffuse background is the major element. A comparison between the cyclic mask camera and the single mask camera is made under various conditions and it is shown the single mask camera has a moderate advantage particularly when imaging a wide field of view. (orig.)

Accuracy of deep learning, a machine-learning technology, using ultra-wide-field fundus ophthalmoscopy for detecting rhegmatogenous retinal detachment.

Science.gov (United States)

Ohsugi, Hideharu; Tabuchi, Hitoshi; Enno, Hiroki; Ishitobi, Naofumi

2017-08-25

Rhegmatogenous retinal detachment (RRD) is a serious condition that can lead to blindness; however, it is highly treatable with timely and appropriate treatment. Thus, early diagnosis and treatment of RRD is crucial. In this study, we applied deep learning, a machine-learning technology, to detect RRD using ultra-wide-field fundus images and investigated its performance. In total, 411 images (329 for training and 82 for grading) from 407 RRD patients and 420 images (336 for training and 84 for grading) from 238 non-RRD patients were used in this study. The deep learning model demonstrated a high sensitivity of 97.6% [95% confidence interval (CI), 94.2-100%] and a high specificity of 96.5% (95% CI, 90.2-100%), and the area under the curve was 0.988 (95% CI, 0.981-0.995). This model can improve medical care in remote areas where eye clinics are not available by using ultra-wide-field fundus ophthalmoscopy for the accurate diagnosis of RRD. Early diagnosis of RRD can prevent blindness.

Improved iris localization by using wide and narrow field of view cameras for iris recognition

Science.gov (United States)

Kim, Yeong Gon; Shin, Kwang Yong; Park, Kang Ryoung

2013-10-01

Biometrics is a method of identifying individuals by their physiological or behavioral characteristics. Among other biometric identifiers, iris recognition has been widely used for various applications that require a high level of security. When a conventional iris recognition camera is used, the size and position of the iris region in a captured image vary according to the X, Y positions of a user's eye and the Z distance between a user and the camera. Therefore, the searching area of the iris detection algorithm is increased, which can inevitably decrease both the detection speed and accuracy. To solve these problems, we propose a new method of iris localization that uses wide field of view (WFOV) and narrow field of view (NFOV) cameras. Our study is new as compared to previous studies in the following four ways. First, the device used in our research acquires three images, one each of the face and both irises, using one WFOV and two NFOV cameras simultaneously. The relation between the WFOV and NFOV cameras is determined by simple geometric transformation without complex calibration. Second, the Z distance (between a user's eye and the iris camera) is estimated based on the iris size in the WFOV image and anthropometric data of the size of the human iris. Third, the accuracy of the geometric transformation between the WFOV and NFOV cameras is enhanced by using multiple matrices of the transformation according to the Z distance. Fourth, the searching region for iris localization in the NFOV image is significantly reduced based on the detected iris region in the WFOV image and the matrix of geometric transformation corresponding to the estimated Z distance. Experimental results showed that the performance of the proposed iris localization method is better than that of conventional methods in terms of accuracy and processing time.

A Method for Eddy Current Field Measurement in Permanent Magnet Magnetic Resonance Imaging Systems

Directory of Open Access Journals (Sweden)

SONG Rui

2018-03-01

Full Text Available Magnetic resonance imaging (MRI is a widely used medical imaging technique. In MRI system, gradient magnetic fields are used to code spatial information. However, the fast-switching electric currents in the gradients coils used to generate gradient fields also induce vortex electric field, often referred as eddy current, in the surrounding metal conductors. In this paper, a method for eddy current field measurement was proposed. Based on the Faraday law of electromagnetic induction, an eddy current field measuring device was designed. Combining hardware acquisition and software processing, the eddy current field was obtained by subtracting the ideal gradient field from the magnetic field measured experimentally, whose waveform could be displayed in real time. The proposed method was verified by experimental results.

Mapping absolute tissue endogenous fluorophore concentrations with chemometric wide-field fluorescence microscopy

Science.gov (United States)

Xu, Zhang; Reilley, Michael; Li, Run; Xu, Min

2017-06-01

We report chemometric wide-field fluorescence microscopy for imaging the spatial distribution and concentration of endogenous fluorophores in thin tissue sections. Nonnegative factorization aided by spatial diversity is used to learn both the spectral signature and the spatial distribution of endogenous fluorophores from microscopic fluorescence color images obtained under broadband excitation and detection. The absolute concentration map of individual fluorophores is derived by comparing the fluorescence from "pure" fluorophores under the identical imaging condition following the identification of the fluorescence species by its spectral signature. This method is then demonstrated by characterizing the concentration map of endogenous fluorophores (including tryptophan, elastin, nicotinamide adenine dinucleotide, and flavin adenine dinucleotide) for lung tissue specimens. The absolute concentrations of these fluorophores are all found to decrease significantly from normal, perilesional, to cancerous (squamous cell carcinoma) tissue. Discriminating tissue types using the absolute fluorophore concentration is found to be significantly more accurate than that achievable with the relative fluorescence strength. Quantification of fluorophores in terms of the absolute concentration map is also advantageous in eliminating the uncertainties due to system responses or measurement details, yielding more biologically relevant data, and simplifying the assessment of competing imaging approaches.

SQUID-Detected Magnetic Resonance Imaging in MicroteslaFields

Energy Technology Data Exchange (ETDEWEB)

Moessle, Michael; Hatridge, Michael; Clarke, John

2006-08-14

Magnetic resonance imaging (MRI) has developed into a powerful clinical tool for imaging the human body (1). This technique is based on nuclear magnetic resonance (NMR) of protons (2, 3) in a static magnetic field B{sub 0}. An applied radiofrequency pulse causes the protons to precess about B{sub 0} at their Larmor frequency {nu}{sub 0} = ({gamma}/2{pi})B{sub 0}, where {gamma} is the gyromagnetic ratio; {gamma}/2{pi} = 42.58 MHz/tesla. The precessing protons generate an oscillating magnetic field and hence a voltage in a nearby coil that is amplified and recorded. The application of three-dimensional magnetic field gradients specifies a unique magnetic field and thus an NMR frequency in each voxel of the subject, so that with appropriate encoding of the signals one can acquire a complete image (4). Most clinical MRI systems involve magnetic fields generated by superconducting magnets, and the current trend is to higher magnetic fields than the widely used 1.5-T systems (5). Nonetheless, there is ongoing interest in the development of less expensive imagers operating at lower fields. Commercially available 0.2-T systems based on permanent magnets offer both lower cost and a more open access than their higher-field counterparts, at the expense of signal-to-noise-ratio (SNR) and spatial resolution. At the still lower field of 0.03 mT maintained by a conventional, room-temperature solenoid, Connolly and co-workers (6, 7) obtain good spatial resolution and signal-to-noise ratio (SNR) by prepolarizing the protons in a field B{sub p} of 0.3 T. Prepolarization (8) enhances the magnetic moment of an ensemble of protons over that produced by the lower precession field; after the polarizing field is removed, the higher magnetic moment produces a correspondingly larger signal during its precession in B{sub 0}. Using the same method, Stepisnik et al. (9) obtained MR images in the Earth's magnetic field ({approx} 50 {micro}T). Alternatively, one can enhance the signal

Multiplexing and de-multiplexing with scattering media for large field of view and multispectral imaging

Science.gov (United States)

Sahoo, Sujit Kumar; Tang, Dongliang; Dang, Cuong

2018-02-01

Large field of view multispectral imaging through scattering medium is a fundamental quest in optics community. It has gained special attention from researchers in recent years for its wide range of potential applications. However, the main bottlenecks of the current imaging systems are the requirements on specific illumination, poor image quality and limited field of view. In this work, we demonstrated a single-shot high-resolution colour-imaging through scattering media using a monochromatic camera. This novel imaging technique is enabled by the spatial, spectral decorrelation property and the optical memory effect of the scattering media. Moreover the use of deconvolution image processing further annihilate above-mentioned drawbacks arise due iterative refocusing, scanning or phase retrieval procedures.

Mapping the Tidal Destruction of the Hercules Dwarf: A Wide-field DECam Imaging Search for RR Lyrae Stars

Science.gov (United States)

Garling, Christopher; Willman, Beth; Sand, David J.; Hargis, Jonathan; Crnojević, Denija; Bechtol, Keith; Carlin, Jeffrey L.; Strader, Jay; Zou, Hu; Zhou, Xu; Nie, Jundan; Zhang, Tianmeng; Zhou, Zhimin; Peng, Xiyan

2018-01-01

We investigate the hypothesized tidal disruption of the Hercules ultra-faint dwarf galaxy (UFD). Previous tidal disruption studies of the Hercules UFD have been hindered by the high degree of foreground contamination in the direction of the dwarf. We bypass this issue by using RR Lyrae stars, which are standard candles with a very low field-volume density at the distance of Hercules. We use wide-field imaging from the Dark Energy Camera on CTIO to identify candidate RR Lyrae stars, supplemented with observations taken in coordination with the Beijing–Arizona Sky Survey on the Bok Telescope. Combining color, magnitude, and light-curve information, we identify three new RR Lyrae stars associated with Hercules. All three of these new RR Lyrae stars lie outside its published tidal radius. When considered with the nine RR Lyrae stars already known within the tidal radius, these results suggest that a substantial fraction of Hercules’ stellar content has been stripped. With this degree of tidal disruption, Hercules is an interesting case between a visibly disrupted dwarf (such as the Sagittarius dwarf spheroidal galaxy) and one in dynamic equilibrium. The degree of disruption also shows that we must be more careful with the ways we determine object membership when estimating dwarf masses in the future. One of the three discovered RR Lyrae stars sits along the minor axis of Hercules, but over two tidal radii away. This type of debris is consistent with recent models that suggest Hercules’ orbit is aligned with its minor axis.

DATA QUALITY EVALUATION AND APPLICATION POTENTIAL ANALYSIS OF TIANGONG-2 WIDE-BAND IMAGING SPECTROMETER

Directory of Open Access Journals (Sweden)

B. Qin

2018-04-01

Full Text Available Tiangong-2 is the first space laboratory in China, which launched in September 15, 2016. Wide-band Imaging Spectrometer is a medium resolution multispectral imager on Tiangong-2. In this paper, the authors introduced the indexes and parameters of Wideband Imaging Spectrometer, and made an objective evaluation about the data quality of Wide-band Imaging Spectrometer in radiation quality, image sharpness and information content, and compared the data quality evaluation results with that of Landsat-8. Although the data quality of Wide-band Imager Spectrometer has a certain disparity with Landsat-8 OLI data in terms of signal to noise ratio, clarity and entropy. Compared with OLI, Wide-band Imager Spectrometer has more bands, narrower bandwidth and wider swath, which make it a useful remote sensing data source in classification and identification of large and medium scale ground objects. In the future, Wide-band Imaging Spectrometer data will be widely applied in land cover classification, ecological environment assessment, marine and coastal zone monitoring, crop identification and classification, and other related areas.

Data Quality Evaluation and Application Potential Analysis of TIANGONG-2 Wide-Band Imaging Spectrometer

Science.gov (United States)

Qin, B.; Li, L.; Li, S.

2018-04-01

Tiangong-2 is the first space laboratory in China, which launched in September 15, 2016. Wide-band Imaging Spectrometer is a medium resolution multispectral imager on Tiangong-2. In this paper, the authors introduced the indexes and parameters of Wideband Imaging Spectrometer, and made an objective evaluation about the data quality of Wide-band Imaging Spectrometer in radiation quality, image sharpness and information content, and compared the data quality evaluation results with that of Landsat-8. Although the data quality of Wide-band Imager Spectrometer has a certain disparity with Landsat-8 OLI data in terms of signal to noise ratio, clarity and entropy. Compared with OLI, Wide-band Imager Spectrometer has more bands, narrower bandwidth and wider swath, which make it a useful remote sensing data source in classification and identification of large and medium scale ground objects. In the future, Wide-band Imaging Spectrometer data will be widely applied in land cover classification, ecological environment assessment, marine and coastal zone monitoring, crop identification and classification, and other related areas.

The LOFT wide field monitor simulator

DEFF Research Database (Denmark)

Donnarumma, I.; Evangelista, Y.; Campana, R.

2012-01-01

We present the simulator we developed for the Wide Field Monitor (WFM) aboard the Large Observatory For Xray Timing (LOFT) mission, one of the four ESA M3 candidate missions considered for launch in the 2022–2024 timeframe. The WFM is designed to cover a large FoV in the same bandpass as the Large...

Wide field of view CT and acromioclavicular joint instability: A technical innovation.

Science.gov (United States)

Dyer, David R; Troupis, John M; Kamali Moaveni, Afshin

2015-06-01

A 21-year-old female with a traumatic shoulder injury is investigated and managed for symptoms relating to this injury. Pathology at the acromioclavicular joint is detected clinically; however, clinical examination and multiple imaging modalities do not reach a unified diagnosis on the grading of this acromioclavicular joint injury. When management appropriate to that suggested injury grading fail to help the patient's symptoms, further investigation methods were utilised. Wide field of view, dynamic CT (4D CT) is conducted on the patient's affected shoulder using a 320 × 0.5 mm detector multislice CT. Scans were conducted with a static table as the patient completed three movements of the affected shoulder. Capturing multiple data sets per second over a z-axis of 16 cm, measurements of the acromioclavicular joint were made, to show dynamic changes at the joint. Acromioclavicular (AC) joint translations were witnessed in three planes (a previously unrecognised pathology in the grading of acromioclavicular joint injuries). Translation in multiple planes was also not evident on careful clinical examination of this patient. AC joint width, anterior-posterior translation, superior-inferior translation and coracoclavicular width were measured with planar reconstructions while volume-rendered images and dynamic sequences aiding visual understanding of the pathology. Wide field of view dynamic CT (4D CT) is an accurate and quick modality to diagnose complex acromioclavicular joint injury. It provides dynamic information that no other modality can; 4D CT shows future benefits for clinical approach to diagnosis and management of acromioclavicular joint injury, and other musculoskeletal pathologies. © 2015 The Royal Australian and New Zealand College of Radiologists.

A World Wide Web Region-Based Image Search Engine

DEFF Research Database (Denmark)

Kompatsiaris, Ioannis; Triantafyllou, Evangelia; Strintzis, Michael G.

2001-01-01

In this paper the development of an intelligent image content-based search engine for the World Wide Web is presented. This system will offer a new form of media representation and access of content available in WWW. Information Web Crawlers continuously traverse the Internet and collect images...

Optical system design of CCD star sensor with large aperture and wide field of view

Science.gov (United States)

Wang, Chao; Jiang, Lun; Li, Ying-chao; Liu, Zhuang

2017-10-01

The star sensor is one of the sensors which are used to determine the spatial attitude of the space vehicle. An optical system of star sensor with large aperture and wide field of view was designed in this paper. The effective focal length of the optics was 16mm, and the F-number is 1.2, the field of view of the optical system is 20°.The working spectrum is 500 to 800 nanometer. The lens system selects a similar complicated Petzval structure and special glass-couple, and get a high imaging quality in the whole spectrum range. For each field-of-view point, the values of the modulation transfer function at 50 cycles/mm is higher than 0.3. On the detecting plane, the encircled energy in a circle of 14μm diameter could be up to 80% of the total energy. In the whole range of the field of view, the dispersion spot diameter in the imaging plane is no larger than 13μm. The full field distortion was less than 0.1%, which was helpful to obtain the accurate location of the reference star through the picture gotten by the star sensor. The lateral chromatic aberration is less than 2μm in the whole spectrum range.

Clustering of quasars in a wide luminosity range at redshift 4 with Subaru Hyper Suprime-Cam Wide-field imaging

Science.gov (United States)

He, Wanqiu; Akiyama, Masayuki; Bosch, James; Enoki, Motohiro; Harikane, Yuichi; Ikeda, Hiroyuki; Kashikawa, Nobunari; Kawaguchi, Toshihiro; Komiyama, Yutaka; Lee, Chien-Hsiu; Matsuoka, Yoshiki; Miyazaki, Satoshi; Nagao, Tohru; Nagashima, Masahiro; Niida, Mana; Nishizawa, Atsushi J.; Oguri, Masamune; Onoue, Masafusa; Oogi, Taira; Ouchi, Masami; Schulze, Andreas; Shirasaki, Yuji; Silverman, John D.; Tanaka, Manobu M.; Tanaka, Masayuki; Toba, Yoshiki; Uchiyama, Hisakazu; Yamashita, Takuji

2018-01-01

We examine the clustering of quasars over a wide luminosity range, by utilizing 901 quasars at \\overline{z}_phot˜ 3.8 with -24.73 Strategic Program (HSC-SSP) S16A Wide2 date release and 342 more luminous quasars at 3.4 Digital Sky Survey that fall in the HSC survey fields. We measure the bias factors of two quasar samples by evaluating the cross-correlation functions (CCFs) between the quasar samples and 25790 bright z ˜ 4 Lyman break galaxies in M1450 < -21.25 photometrically selected from the HSC dataset. Over an angular scale of 10.0" to 1000.0", the bias factors are 5.93+1.34-1.43 and 2.73+2.44-2.55 for the low- and high-luminosity quasars, respectively, indicating no significant luminosity dependence of quasar clustering at z ˜ 4. It is noted that the bias factor of the luminous quasars estimated by the CCF is smaller than that estimated by the auto-correlation function over a similar redshift range, especially on scales below 40.0". Moreover, the bias factor of the less-luminous quasars implies the minimal mass of their host dark matter halos is 0.3-2 × 1012 h-1 M⊙, corresponding to a quasar duty cycle of 0.001-0.06.

Quality of radiation field imaging

International Nuclear Information System (INIS)

Petr, I.

1988-01-01

The questions were studied of the quality of imaging the gamma radiation field and of the limits of the quality in directional detector scanning. A resolution angle was introduced to quantify the imaging quality, and its relation was sought with the detection effective half-angle of the directional detector. The resolution angle was defined for the simplest configuration of the radiation field consisting of two monoenergetic gamma beams in one plane. It was shown that the resolution angle decreases, i.e., resolution in imaging the radiation field is better, with the effective half-angle of the directional detector. It was also found that resolution of both gamma beams deteriorated when the beams were surrounded with an isotropic background field. If the beams are surrounded with a background field showing general distribution, the angle size will be affected not only by the properties of the detector but also by the distribution of the ambient radiation field and the method of its scanning. The method described can be applied in designing a directional detector necessary for imaging the presumed radiation field in the required quality. (Z.M.). 4 figs., 3 refs

Argus+: The Future of Wide-Field, Spectral-Line Imaging at 3-mm with the Green Bank Telescope

Science.gov (United States)

Maddalena, Ronald; Frayer, David; Lockman, Felix; O'Neil, Karen; White, Steven; Argus+ Collaboration

2018-01-01

The Robert C Byrd Green Bank Telescope has met its design goal of providing high-quality observations at 115 GHz. Observers also have access to the new, 16-pixel, 3-mm Argus receiver, which is providing high-dynamic range images over wide fields for the multitude of spectral lines between 85 and 115 GHz, including CO, 13CO, C18O, SiO, HCN, HCO+, HNC, N2H+, and CS. The small number of pixels in Argus limits its ability to map many of the most interesting objects whose extent exceeds many arc-minutes. The successful performance of Argus, and its modular design, demonstrates that receivers with many more pixels could be built for the GBT. A 12 x 12 array of the Argus design would have mapping speeds about nine times faster than Argus without suffering any degradation in performance for the outer pixels in the array. We present our plans to build the next-generation Argus instrument (Argus+) with 144-pixels, a footprint 5’x5’, and 7" resolution at 110 GHz. The project will be a collaboration between the Green Bank Observatory and university groups, who will supply key components. The key science drivers for Argus+ are studies of molecular filaments in the Milky Way, studies of molecular clouds in nearby galaxies, and the observations of rapidly evolving solar system objects.

Innovative compact focal plane array for wide field vis and ir orbiting telescopes

Science.gov (United States)

Hugot, Emmanuel; Vives, Sébastien; Ferrari, Marc; Gaeremynck, Yann; Jahn, Wilfried

2017-11-01

The future generation of high angular resolution space telescopes will require breakthrough technologies to combine large diameters and large focal plane arrays with compactness and lightweight mirrors and structures. Considering the allocated volume medium-size launchers, short focal lengths are mandatory, implying complex optical relays to obtain diffraction limited images on large focal planes. In this paper we present preliminary studies to obtain compact focal plane arrays (FPA) for earth observations on low earth orbits at high angular resolution. Based on the principle of image slicers, we present an optical concept to arrange a 1D FPA into a 2D FPA, allowing the use of 2D detector matrices. This solution is particularly attractive for IR imaging requiring a cryostat, which volume could be considerably reduced as well as the relay optics complexity. Enabling the use of 2D matrices for such an application offers new possibilities. Recent developments on curved FPA allows optimization without concerns on the field curvature. This innovative approach also reduces the complexity of the telescope optical combination, specifically for fast telescopes. This paper will describe the concept and optical design of an F/5 - 1.5m telescope equipped with such a FPA, the performances and the impact on the system with a comparison with an equivalent 1.5m wide field Korsch telescope.

Retinal pigment epithelium findings in patients with albinism using wide-field polarization-sensitive optical coherence tomography.

Science.gov (United States)

Schütze, Christopher; Ritter, Markus; Blum, Robert; Zotter, Stefan; Baumann, Bernhard; Pircher, Michael; Hitzenberger, Christoph K; Schmidt-Erfurth, Ursula

2014-11-01

To investigate pigmentation characteristics of the retinal pigment epithelium (RPE) in patients with albinism using wide-field polarization-sensitive optical coherence tomography compared with intensity-based spectral domain optical coherence tomography and fundus autofluorescence imaging. Five patients (10 eyes) with previously genetically diagnosed albinism and 5 healthy control subjects (10 eyes) were imaged by a wide-field polarization-sensitive optical coherence tomography system (scan angle: 40 × 40° on the retina), sensitive to melanin contained in the RPE, based on the polarization state of backscattered light. Conventional intensity-based spectral domain optical coherence tomography and fundus autofluorescence examinations were performed. Retinal pigment epithelium-pigmentation was analyzed qualitatively and quantitatively based on depolarization assessed by polarization-sensitive optical coherence tomography. This study revealed strong evidence of polarization-sensitive optical coherence tomography to specifically image melanin in the RPE. Depolarization of light backscattered by the RPE in patients with albinism was reduced compared with normal subjects. Heterogeneous RPE-specific depolarization characteristics were observed in patients with albinism. Reduction of depolarization observed in the light backscattered by the RPE in patients with albinism corresponds to expected decrease of RPE pigmentation. The degree of depigmentation of the RPE is possibly associated with visual acuity. Findings suggest that different albinism genotypes result in heterogeneous levels of RPE pigmentation. Polarization-sensitive optical coherence tomography showed a heterogeneous appearance of RPE pigmentation in patients with albinism depending on different genotypes.

A Multispectral Micro-Imager for Lunar Field Geology

Science.gov (United States)

Nunez, Jorge; Farmer, Jack; Sellar, Glenn; Allen, Carlton

2009-01-01

Field geologists routinely assign rocks to one of three basic petrogenetic categories (igneous, sedimentary or metamorphic) based on microtextural and mineralogical information acquired with a simple magnifying lens. Indeed, such observations often comprise the core of interpretations of geological processes and history. The Multispectral Microscopic Imager (MMI) uses multi-wavelength, light-emitting diodes (LEDs) and a substrate-removed InGaAs focal-plane array to create multispectral, microscale reflectance images of geological samples (FOV 32 X 40 mm). Each pixel (62.5 microns) of an image is comprised of 21 spectral bands that extend from 470 to 1750 nm, enabling the discrimination of a wide variety of rock-forming minerals, especially Fe-bearing phases. MMI images provide crucial context information for in situ robotic analyses using other onboard analytical instruments (e.g. XRD), or for the selection of return samples for analysis in terrestrial labs. To further assess the value of the MMI as a tool for lunar exploration, we used a field-portable, tripod-mounted version of the MMI to image a variety of Apollo samples housed at the Lunar Experiment Laboratory, NASA s Johnson Space Center. MMI images faithfully resolved the microtextural features of samples, while the application of ENVI-based spectral end member mapping methods revealed the distribution of Fe-bearing mineral phases (olivine, pyroxene and magnetite), along with plagioclase feldspars within samples. Samples included a broad range of lithologies and grain sizes. Our MMI-based petrogenetic interpretations compared favorably with thin section-based descriptions published in the Lunar Sample Compendium, revealing the value of MMI images for astronaut and rover-mediated lunar exploration.

An optical super-microscope for far-field, real-time imaging beyond the diffraction limit.

Science.gov (United States)

Wong, Alex M H; Eleftheriades, George V

2013-01-01

Optical microscopy suffers from a fundamental resolution limitation arising from the diffractive nature of light. While current solutions to sub-diffraction optical microscopy involve combinations of near-field, non-linear and fine scanning operations, we hereby propose and demonstrate the optical super-microscope (OSM) - a superoscillation-based linear imaging system with far-field working and observation distances - which can image an object in real-time and with sub-diffraction resolution. With our proof-of-principle prototype we report a point spread function with a spot size clearly reduced from the diffraction limit, and demonstrate corresponding improvements in two-point resolution experiments. Harnessing a new understanding of superoscillations, based on antenna array theory, our OSM achieves far-field, sub-diffraction optical imaging of an object without the need for fine scanning, data post-processing or object pre-treatment. Hence the OSM can be used in a wide variety of imaging applications beyond the diffraction limit, including real-time imaging of moving objects.

A DEEP, WIDE-FIELD Hα SURVEY OF NEARBY CLUSTERS OF GALAXIES: DATA

International Nuclear Information System (INIS)

Sakai, Shoko; Kennicutt, Robert C. Jr.; Moss, Chris

2012-01-01

We present the results of a wide-field Hα imaging survey of eight nearby (z = 0.02-0.03) Abell clusters. We have measured Hα fluxes and equivalent widths for 465 galaxies, of which 360 are new detections. The survey was designed to obtain complete emission-line-selected inventories of star-forming galaxies in the inner regions of these clusters, extending to star formation rates below 0.1 M ☉ yr –1 . This paper describes the observations, data processing, and source identification procedures, and presents an Hα and R-band catalog of detected cluster members and other candidates. Future papers in the series will use these data to study the completeness of spectroscopically based star formation surveys, and to quantify the effects of cluster environment on the present-day populations of star-forming galaxies. The data will also provide a valuable foundation for imaging surveys of redshifted Hα emission in more distant clusters.

A Case Study of On-the-fly Wide-field Radio Imaging Applied to the Gravitational Wave Event GW151226

Science.gov (United States)

Mooley, K. P.; Frail, D. A.; Myers, S. T.; Kulkarni, S. R.; Hotokezaka, K.; Singer, L. P.; Horesh, A.; Kasliwal, M. M.; Cenko, S. B.; Hallinan, G.

2018-04-01

We apply a newly developed on-the-fly mosaicing technique on the Jansky Very Large Array (VLA) at 3 GHz in order to carry out a sensitive search for an afterglow from the Advanced LIGO binary black hole merger event GW151226. In three epochs between 1.5 and 6 months post-merger, we observed a 100 deg2 region, with more than 80% of the survey region having an rms sensitivity of better than 150 μJy/beam, in the northern hemisphere with a merger containment probability of 10%. The data were processed in near real time and analyzed to search for transients and variables. No transients were found but we have demonstrated the ability to conduct blind searches in a time-frequency phase space where the predicted afterglow signals are strongest. If the gravitational wave event is contained within our survey region, the upper limit on any late-time radio afterglow from the merger event at an assumed mean distance of 440 Mpc is about 1029 erg s‑1 Hz‑1. Approximately 1.5% of the radio sources in the field showed variability at a level of 30%, and can be attributed to normal activity from active galactic nuclei. The low rate of false positives in the radio sky suggests that wide-field imaging searches at a few Gigahertz can be an efficient and competitive search strategy. We discuss our search method in the context of the recent afterglow detection from GW170817 and radio follow-up in future gravitational wave observing runs.

A review of images of nurses and smoking on the World Wide Web.

Science.gov (United States)

Sarna, Linda; Bialous, Stella Aguinaga

2012-01-01

With the advent of the World Wide Web, historic images previously having limited distributions are now widely available. As tobacco use has evolved, so have images of nurses related to smoking. Using a systematic search, the purpose of this article is to describe types of images of nurses and smoking available on the World Wide Web. Approximately 10,000 images of nurses and smoking published over the past century were identified through search engines and digital archives. Seven major themes were identified: nurses smoking, cigarette advertisements, helping patients smoke, "naughty" nurse, teaching women to smoke, smoking in and outside of health care facilities, and antitobacco images. The use of nursing images to market cigarettes was known but the extent of the use of these images has not been reported previously. Digital archives can be used to explore the past, provide a perspective for understanding the present, and suggest directions for the future in confronting negative images of nursing. Copyright © 2012 Elsevier Inc. All rights reserved.

The Herschel-SPIRE Legacy Survey (HSLS): the scientific goals of a shallow and wide submillimeter imaging survey with SPIRE

NARCIS (Netherlands)

Cooray, Asantha; Eales, Steve; Chapman, Scott; Clements, David L.; Dore, Olivier; Farrah, Duncan; Jarvis, Matt J.; Kaplinghat, Manoj; Negrello, Mattia; Melchiorri, Alessandro; Peiris, Hiranya; Pope, Alexandra; Santos, Mario G.; Serjeant, Stephen; Thompson, Mark; White, Glenn; Amblard, Alexandre; Banerji, Manda; Corasaniti, Pier-Stefano; Das, Sudeep; de Bernardis, Francesco; de Zotti, Gianfranco; Giannantonio, Tommaso; Gonzalez-Nuevo Gonzalez, Joaquin; Khostovan, Ali Ahmad; Mitchell-Wynne, Ketron; Serra, Paolo; Song, Yong-Seon; Vieira, Joaquin; Wang, Lingyu; Zemcov, Michael; Abdalla, Filipe; Afonso, Jose; Aghanim, Nabila; Andreani, Paola; Aretxaga, Itziar; Auld, Robbie; Baes, Maarten; Baker, Andrew; Barkats, Denis; Belen Barreiro, R.; Bartolo, Nicola; Barton, Elizabeth; Barway, Sudhanshu; Stefano Battistelli, Elia; Baugh, Carlton; Holwerda, Benne W.; Koopmans, Leon; Pohlen, Michael; Vegetti, Simona

2010-01-01

A large sub-mm survey with Herschel will enable many exciting science opportunities, especially in an era of wide-field optical and radio surveys and high resolution cosmic microwave background experiments. The Herschel-SPIRE Legacy Survey (HSLS), will lead to imaging data over 4000 sq. degrees at

76 FR 46854 - Hewlett Packard Company, Imaging and Printing Group, World Wide Product Data Management...

Science.gov (United States)

2011-08-03

..., Imaging and Printing Group, World Wide Product Data Management Operations, Including On-Site Leased... Company, Imaging and Printing Group, World Wide Products Data Management Operations, Boise, Idaho and Fort... of Hewlett Packard Company, Imaging and Printing Group, World Wide Product Data Management Operations...

Active feedback wide-field optical low-coherence interferometry for ultrahigh-speed three-dimensional morphometry

International Nuclear Information System (INIS)

Choi, Woo June; Choi, Hae Young; Lee, Byeong Ha; Na, Jihoon; Eom, Jonghyun

2010-01-01

A novel optical interferometric scheme for ultrahigh-speed three-dimensional morphometry is proposed. The system is based on wide-field optical coherence tomography (WF-OCT) but with optically chopped illumination. The chopping frequency is feedback-controlled to be always matched with the Doppler frequency of the OCT interferometer, which provides an efficient page-wide demodulation suitable for ultrahigh-speed volumetric imaging. To compensate the unwanted variation in the OCT Doppler frequency of the system, the illumination frequency is phase-locked with an auxiliary laser interferometer which shares the reference arm with the OCT interferometer. The two-dimensional (2D) interference signals projected on the 2D array pixels of a 200 Hz CCD are accumulated during one imaging frame of the CCD. Then, each pixel of the CCD demodulates the OCT signal automatically. Owing to the proposed active frequency-locked illumination scheme, the demodulation does not depend on the variation in the axial scanning speed. Volumetric topograms or/and tomograms of several samples were achieved and rendered with a sensitivity of 58 dB at an axial scan speed of 0.805 mm s −1

Wide-field kinematic structure of early-type galaxy halos

Science.gov (United States)

Arnold, Jacob Antony

2013-12-01

The stellar halos of nearby galaxies bare the signatures of the mass-assembly processes that have driven galaxy evolution over the last ˜10 Gyr. Finding and interpreting these relict clues in galaxies within and beyond the local group offers one of the most promising avenues for understanding how galaxies accumulate their stars over time. To tackle this problem we have performed a systematic study of the wide-field kinematic structure of nearby (Dspectroscopy out to several effective radii (˜3 R e). The 22 galaxies presented here span a range of environments (field, group, and cluster), intrinsic luminosities (-22.4 infrared Calcium II triplet. For each spectrum, we parameterize the line-of-sight velocity distribution (LOSVD) as a truncated Gauss-Hermite series convolved with an optimally weighted combination of stellar templates. These kinematic measurements (V, sigma, h3, and h4) are combined with literature values to construct spatially resolved maps of large-scale kinematic structure. A variety of kinematic behaviors are observed beyond ~1 Re, potentially reflecting the stochastic and chaotic assembly of stellar bulges and halos in early-type galaxies. Next, we describe a global analysis (out to 5 Re) of kinematics and metallicity in the nearest S0 galaxy, NGC 3115, along with implications for its assembly history. The data include high-quality wide-field imaging and multi-slit spectra of the field stars and globular clusters (GCs). Within two effective radii, the bulge (as traced by the stars and metal-rich GCs) is flattened and rotates rapidly. At larger radii, the rotation declines dramatically, while the characteristic GC metallicities also decrease with radius. We argue that this pattern is not naturally explained by a binary major merger, but instead by a two-phase assembly process where the inner regions have formed in an early violent, dissipative phase, followed by the protracted growth of the outer parts via minor mergers. To test this hypothesis

Development of field-wide risk based remediation objectives for an aging oil field : Devon Canada Swan Hills Field

Energy Technology Data Exchange (ETDEWEB)

Brewster, M.; North, C.; Leighton-Boyce, G. [WorleyParsons Komex, Calgary, AB (Canada); Moore, D. [Devon Canada Corp., Calgary, AB (Canada)

2006-07-01

The development of field-wide risk based remediation objectives for the aging Devon Canada Swan Hills oil field was examined along with the key components of the closure strategy. These included source removal to the extent practical, long term monitoring, and achievable risk-based remedial objectives that were appropriate to the remote boreal forest setting of the Swan Hills field. A two stage approach was presented. The first stage involved a field wide background framework which included defining areas of common physical and ecological setting and developing appropriate exposure scenarios. The second stage involved site-specific risk assessments which included adjusting for site-specific conditions and an early demonstration project to prove the concept. A GIS approach was used to identify areas of common physical and ecological setting including: physiography; surface water; land use; vegetation ecozones; surficial and bedrock geology; and water well use. Species lists were compiled for vegetation, terrestrial wildlife (mammals, birds, amphibians), and aquatic species (fish and invertebrates). Major contaminant sources, problem formulation, vegetation bioassays, invertebrate bioassays, black spruce emergence, and guideline development were other topics covered during the presentation. Last, a summary of progress was presented. A field-wide review and development of risk zones and site-specific risk assessment has been completed. A regulatory review is underway. tabs., figs.

Stratigraphic imaging of sub-basalt sediments using waveform tomography of wide-angle seismic data

Science.gov (United States)

Sain, K.; Gao, F.; Pratt, G.; Zelt, C. A.

2003-12-01

The oil industry is interested in imaging the fine structures of sedimentary formations masked below basalt flows for commercial exploration of hydrocarbons. Seismic exploration of sediments hidden below high-velocity basalt cover is a difficult problem because near-vertical reflection data are contaminated with multiples, converted waves and scattering noise generated by interbeds, breccia and vesicles within the basalt. The noise becomes less prominent as the source-receiver offset increases, and the signals carrying sub-surface information stand out at the wide-angle range. The tomography of first arrival traveltime data can provide little information about the underlying low-velocity sediments. Traveltime inversion of wide-angle seismic data including both first arrivals and identifiable wide-angle reflected phases has been an important tool in the delineation of the large-scale velocity structure of sub-basalt sediments, although it lacks the small-scale velocity details. Here we apply 2-D full-waveform inversion ("waveform tomography") to wide-angle seismic data with a view to extracting the small-scale stratigraphic features of sedimentary formations. Results from both synthetic data, generated for a realistic earth model, and field dataset from the basalt covered Saurashtra peninsula, India, will be presented. This approach has potential to delineate thin sedimentary layers hidden below thick basalt cover also, and may serve as a powerful tool to image sedimentary basins, where they are covered by high-velocity materials like basalts, salts, carbonates, etc. in various parts of the world.

Camera Trajectory fromWide Baseline Images

Science.gov (United States)

Havlena, M.; Torii, A.; Pajdla, T.

2008-09-01

Camera trajectory estimation, which is closely related to the structure from motion computation, is one of the fundamental tasks in computer vision. Reliable camera trajectory estimation plays an important role in 3D reconstruction, self localization, and object recognition. There are essential issues for a reliable camera trajectory estimation, for instance, choice of the camera and its geometric projection model, camera calibration, image feature detection and description, and robust 3D structure computation. Most of approaches rely on classical perspective cameras because of the simplicity of their projection models and ease of their calibration. However, classical perspective cameras offer only a limited field of view, and thus occlusions and sharp camera turns may cause that consecutive frames look completely different when the baseline becomes longer. This makes the image feature matching very difficult (or impossible) and the camera trajectory estimation fails under such conditions. These problems can be avoided if omnidirectional cameras, e.g. a fish-eye lens convertor, are used. The hardware which we are using in practice is a combination of Nikon FC-E9 mounted via a mechanical adaptor onto a Kyocera Finecam M410R digital camera. Nikon FC-E9 is a megapixel omnidirectional addon convertor with 180° view angle which provides images of photographic quality. Kyocera Finecam M410R delivers 2272×1704 images at 3 frames per second. The resulting combination yields a circular view of diameter 1600 pixels in the image. Since consecutive frames of the omnidirectional camera often share a common region in 3D space, the image feature matching is often feasible. On the other hand, the calibration of these cameras is non-trivial and is crucial for the accuracy of the resulting 3D reconstruction. We calibrate omnidirectional cameras off-line using the state-of-the-art technique and Mičušík's two-parameter model, that links the radius of the image point r to the

Two wide-angle imaging neutral-atom spectrometers (TWINS)

International Nuclear Information System (INIS)

McComas, D.J.; Blake, B.; Burch, J.

1998-01-01

Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) is a revolutionary new mission designed to stereoscopically image the magnetosphere in charge exchange neutral atoms for the first time. The authors propose to fly two identical TWINS instruments as a mission of opportunity on two widely-spaced high-altitude, high-inclination US Government spacecraft. Because the spacecraft are funded independently, TWINS can provide a vast quantity of high priority science observations (as identified in an ongoing new missions concept study and the Sun-Earth Connections Roadmap) at a small fraction of the cost of a dedicated mission. Because stereo observations of the near-Earth space environs will provide a particularly graphic means for visualizing the magnetosphere in action, and because of the dedication and commitment of the investigator team to the principles of carrying space science to the broader audience, TWINS will also be an outstanding tool for public education and outreach

Automatic Generation of Wide Dynamic Range Image without Pseudo-Edge Using Integration of Multi-Steps Exposure Images

Science.gov (United States)

Migiyama, Go; Sugimura, Atsuhiko; Osa, Atsushi; Miike, Hidetoshi

Recently, digital cameras are offering technical advantages rapidly. However, the shot image is different from the sight image generated when that scenery is seen with the naked eye. There are blown-out highlights and crushed blacks in the image that photographed the scenery of wide dynamic range. The problems are hardly generated in the sight image. These are contributory cause of difference between the shot image and the sight image. Blown-out highlights and crushed blacks are caused by the difference of dynamic range between the image sensor installed in a digital camera such as CCD and CMOS and the human visual system. Dynamic range of the shot image is narrower than dynamic range of the sight image. In order to solve the problem, we propose an automatic method to decide an effective exposure range in superposition of edges. We integrate multi-step exposure images using the method. In addition, we try to erase pseudo-edges using the process to blend exposure values. Afterwards, we get a pseudo wide dynamic range image automatically.

Wide-azimuth angle-domain imaging for anisotropic reverse-time migration

KAUST Repository

Sava, Paul C.; Alkhalifah, Tariq Ali

2011-01-01

Extended common-image-point gathers (CIP) constructed by wide-azimuth TI wave-equation migration contain all the necessary information for angle decomposition as a function of the reflection and azimuth angles at selected locations in the subsurface. The reflection and azimuth angles are derived from the extended images using analytic relations between the space-lag and time-lag extensions. This post-imaging decomposition requires only information which is already available at the time of migration, i.e. the model parameters and the tilt angles of the TI medium. The transformation amounts to a linear Radon transform applied to the CIPs obtained after the application of the extended imaging condition. If information about the reflector dip is available at the CIP locations, then only two components of the space-lag vectors are required, thus reducing computational cost and increasing the affordability of the method. This efficient angle decomposition method is suitable for wide-azimuth imaging in anisotropic media with arbitrary orientation of the symmetry plane. © 2011 Society of Exploration Geophysicists.

Speckle suppression via sparse representation for wide-field imaging through turbid media.

Science.gov (United States)

Jang, Hwanchol; Yoon, Changhyeong; Chung, Euiheon; Choi, Wonshik; Lee, Heung-No

2014-06-30

Speckle suppression is one of the most important tasks in the image transmission through turbid media. Insufficient speckle suppression requires an additional procedure such as temporal ensemble averaging over multiple exposures. In this paper, we consider the image recovery process based on the so-called transmission matrix (TM) of turbid media for the image transmission through the media. We show that the speckle left unremoved in the TM-based image recovery can be suppressed effectively via sparse representation (SR). SR is a relatively new signal reconstruction framework which works well even for ill-conditioned problems. This is the first study to show the benefit of using the SR as compared to the phase conjugation (PC) a de facto standard method to date for TM-based imaging through turbid media including a live cell through tissue slice.

Wide field X-ray telescopes: Detecting X-ray transients/afterglows related to gamma ray bursts

International Nuclear Information System (INIS)

Hudec, Rene; Pina, Ladislav; Inneman, Adolf; Gorenstein, Paul; Rezek, Tomas

1999-01-01

The recent discovery of X-ray afterglows of GRBs opens the possibility of analyses of GRBs by their X-ray detections. However, imaging X-ray telescopes in current use mostly have limited field of view. Alternative X-ray optics geometries achieving very large fields of view have been theoretically suggested in the 70ies but not constructed and used so far. We review the geometries and basic properties of the wide-field X-ray optical systems based on one- and two-dimensional lobster-eye geometry and suggest technologies for their development and construction. First results of the development of double replicated X-ray reflecting flats for use in one-dimensional X-ray optics of lobster eye type are presented and discussed. Optimum strategy for locating GRBs upon their X-ray counterparts is also presented and discussed

Image-optimized Coronal Magnetic Field Models

Energy Technology Data Exchange (ETDEWEB)

Jones, Shaela I.; Uritsky, Vadim; Davila, Joseph M., E-mail: shaela.i.jones-mecholsky@nasa.gov, E-mail: shaela.i.jonesmecholsky@nasa.gov [NASA Goddard Space Flight Center, Code 670, Greenbelt, MD 20771 (United States)

2017-08-01

We have reported previously on a new method we are developing for using image-based information to improve global coronal magnetic field models. In that work, we presented early tests of the method, which proved its capability to improve global models based on flawed synoptic magnetograms, given excellent constraints on the field in the model volume. In this follow-up paper, we present the results of similar tests given field constraints of a nature that could realistically be obtained from quality white-light coronagraph images of the lower corona. We pay particular attention to difficulties associated with the line-of-sight projection of features outside of the assumed coronagraph image plane and the effect on the outcome of the optimization of errors in the localization of constraints. We find that substantial improvement in the model field can be achieved with these types of constraints, even when magnetic features in the images are located outside of the image plane.

Image-Optimized Coronal Magnetic Field Models

Science.gov (United States)

Jones, Shaela I.; Uritsky, Vadim; Davila, Joseph M.

2017-01-01

We have reported previously on a new method we are developing for using image-based information to improve global coronal magnetic field models. In that work we presented early tests of the method which proved its capability to improve global models based on flawed synoptic magnetograms, given excellent constraints on the field in the model volume. In this follow-up paper we present the results of similar tests given field constraints of a nature that could realistically be obtained from quality white-light coronagraph images of the lower corona. We pay particular attention to difficulties associated with the line-of-sight projection of features outside of the assumed coronagraph image plane, and the effect on the outcome of the optimization of errors in localization of constraints. We find that substantial improvement in the model field can be achieved with this type of constraints, even when magnetic features in the images are located outside of the image plane.

Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm.

Science.gov (United States)

Mohler, Kathrin J; Draxinger, Wolfgang; Klein, Thomas; Kolb, Jan Philip; Wieser, Wolfgang; Haritoglou, Christos; Kampik, Anselm; Fujimoto, James G; Neubauer, Aljoscha S; Huber, Robert; Wolf, Armin

2015-10-01

To demonstrate ultrahigh-speed swept-source optical coherence tomography (SS-OCT) at 1.68 million A-scans/s for choroidal imaging in normal and diseased eyes over a ∼60° field of view. To investigate and correlate wide-field three-dimensional (3D) choroidal thickness (ChT) and vascular patterns using ChT maps and coregistered high-definition en face images extracted from a single densely sampled Megahertz-OCT (MHz-OCT) dataset. High-definition, ∼60° wide-field 3D datasets consisting of 2088 × 1024 A-scans were acquired using a 1.68 MHz prototype SS-OCT system at 1050 nm based on a Fourier-domain mode-locked laser. Nine subjects (nine eyes) with various chorioretinal diseases or without ocular pathology are presented. Coregistered ChT maps, choroidal summation maps, and depth-resolved en face images referenced to either the retinal pigment epithelium or the choroidal-scleral interface were generated using manual segmentation. Wide-field ChT maps showed a large inter- and intraindividual variance in peripheral and central ChT. In only four of the nine eyes, the location with the largest ChT was coincident with the fovea. The anatomy of the large lumen vessels of the outer choroid seems to play a major role in determining the global ChT pattern. Focal ChT changes with large thickness gradients were observed in some eyes. Different ChT and vascular patterns could be visualized over ∼60° in patients for the first time using OCT. Due to focal ChT changes, a high density of thickness measurements may be favorable. High-definition depth-resolved en face images are complementary to cross sections and thickness maps and enhance the interpretation of different ChT patterns.

Wide Angle Michelson Doppler Imaging Interferometer (WAMDII)

Science.gov (United States)

Roberts, B.

1986-01-01

The wide angle Michelson Doppler imaging interferometer (WAMDII) is a specialized type of optical Michelson interferometer working at sufficiently long path difference to measure Doppler shifts and to infer Doppler line widths of naturally occurring upper atmospheric Gaussian line emissions. The instrument is intended to measure vertical profiles of atmospheric winds and temperatures within the altitude range of 85 km to 300 km. The WAMDII consists of a Michelson interferometer followed by a camera lens and an 85 x 106 charge coupled device photodiode array. Narrow band filters in a filter wheel are used to isolate individual line emissions and the lens forms an image of the emitting region on the charge coupled device array.

Wide Field Infrared Survey Telescope [WFIRST]: telescope design and simulated performance

Science.gov (United States)

Goullioud, R.; Content, D. A.; Kuan, G. M.; Moore, J. D.; Chang, Z.; Sunada, E. T.; Villalvazo, J.; Hawk, J. P.; Armani, N. V.; Johnson, E. L.; Powell, C. A.

2012-09-01

The Wide Field Infrared Survey Telescope (WFIRST) mission concept was ranked first in new space astrophysics missions by the Astro2010 Decadal Survey, incorporating the Joint Dark Energy Mission payload concept and multiple science white papers. This mission is based on a space telescope at L2 studying exoplanets [via gravitational microlensing], probing dark energy, and surveying the near infrared sky. Since the release of the Astro2010 Decadal Survey, the team has been working with the WFIRST Science Definition Team to refine mission and payload concepts. We present the current interim reference mission point design of the payload, based on the use of a 1.3m unobscured aperture three mirror anastigmat form, with focal imaging and slit-less spectroscopy science channels. We also present the first results of Structural/Thermal/Optical performance modeling of the telescope point design.

Wide-field lifetime-based FRET imaging for the assessment of early functional distribution of transferrin-based delivery in breast tumor-bearing small animals

Science.gov (United States)

Sinsuebphon, Nattawut; Rudkouskaya, Alena; Barroso, Margarida; Intes, Xavier

2016-02-01

Targeted drug delivery is a critical aspect of successful cancer therapy. Assessment of dynamic distribution of the drug provides relative concentration and bioavailability at the target tissue. The most common approach of the assessment is intensity-based imaging, which only provides information about anatomical distribution. Observation of biomolecular interactions can be performed using Förster resonance energy transfer (FRET). Thus, FRET-based imaging can assess functional distribution and provide potential therapeutic outcomes. In this study, we used wide-field lifetime-based FRET imaging for the study of early functional distribution of transferrin delivery in breast cancer tumor models in small animals. Transferrin is a carrier for cancer drug delivery. Its interaction with its receptor is within a few nanometers, which is suitable for FRET. Alexa Fluor® 700 and Alexa Fluor® 750 were conjugated to holo-transferrin which were then administered via tail vein injection to the mice implanted with T47D breast cancer xenografts. Images were continuously acquired for 60 minutes post-injection. The results showed that transferrin was primarily distributed to the liver, the urinary bladder, and the tumor. The cellular uptake of transferrin, which was indicated by the level of FRET, was high in the liver but very low in the urinary bladder. The results also suggested that the fluorescence intensity and FRET signals were independent. The liver showed increasing intensity and increasing FRET during the observation period, while the urinary bladder showed increasing intensity but minimal FRET. Tumors gave varied results corresponding to their FRET progression. These results were relevant to the biomolecular events that occurred in the animals.

Visualizing spatial and temporal heterogeneity of single molecule rotational diffusion in a glassy polymer by defocused wide-field imaging

NARCIS (Netherlands)

Uji-i, Hiroshi; Melnikov, Sergey M.; Deres, Ania; Bergamini, Giacomo; Schryver, Frans De; Herrmann, Andreas; Müllen, Klaus; Enderlein, Jörg; Hofkens, Johan

2006-01-01

Defocused wide-field fluorescence microscopy was used to follow the 3D molecular rotational diffusion of a fluorescent probe molecule in a polymer thin film. The technique allows for visualizing the molecular reorientation both in-plane and out-of-plane. The local environmental change driven by

Update on wide- and ultra-widefield retinal imaging

Directory of Open Access Journals (Sweden)

Samir S Shoughy

2015-01-01

Full Text Available The peripheral retina is the site of pathology in many ocular diseases and ultra-widefield (UWF imaging is one of the new technologies available to ophthalmologists to manage some of these diseases. Currently, there are several imaging systems used in practice for the purpose of diagnostic, monitoring disease progression or response to therapy, and telemedicine. These include modalities for both adults and pediatric patients. The current systems are capable of producing wide- and UWF color fundus photographs, fluorescein and indocyanine green angiograms, and autofluorescence images. Using this technology, important clinical observations have been made in diseases such as diabetic retinopathy, uveitides, retinal vascular occlusions and tumors, intraocular tumors, retinopathy of prematurity, and age-related macular degeneration. Widefield imaging offers excellent postoperative documentation of retinal detachment surgery. New applications will soon be available to integrate this technology into large volume routine clinical practice.

Real-time, wide-area hyperspectral imaging sensors for standoff detection of explosives and chemical warfare agents

Science.gov (United States)

Gomer, Nathaniel R.; Tazik, Shawna; Gardner, Charles W.; Nelson, Matthew P.

2017-05-01

Hyperspectral imaging (HSI) is a valuable tool for the detection and analysis of targets located within complex backgrounds. HSI can detect threat materials on environmental surfaces, where the concentration of the target of interest is often very low and is typically found within complex scenery. Unfortunately, current generation HSI systems have size, weight, and power limitations that prohibit their use for field-portable and/or real-time applications. Current generation systems commonly provide an inefficient area search rate, require close proximity to the target for screening, and/or are not capable of making real-time measurements. ChemImage Sensor Systems (CISS) is developing a variety of real-time, wide-field hyperspectral imaging systems that utilize shortwave infrared (SWIR) absorption and Raman spectroscopy. SWIR HSI sensors provide wide-area imagery with at or near real time detection speeds. Raman HSI sensors are being developed to overcome two obstacles present in standard Raman detection systems: slow area search rate (due to small laser spot sizes) and lack of eye-safety. SWIR HSI sensors have been integrated into mobile, robot based platforms and handheld variants for the detection of explosives and chemical warfare agents (CWAs). In addition, the fusion of these two technologies into a single system has shown the feasibility of using both techniques concurrently to provide higher probability of detection and lower false alarm rates. This paper will provide background on Raman and SWIR HSI, discuss the applications for these techniques, and provide an overview of novel CISS HSI sensors focusing on sensor design and detection results.

Wide-angle imaging LIDAR (WAIL): a ground-based instrument for monitoring the thickness and density of optically thick clouds

International Nuclear Information System (INIS)

Love, Steven P.; Davis, A.B.; Rohde, C.A.; Ho, Cheng

2001-01-01

Traditional lidar provides little information on dense clouds beyond the range to their base (ceilometry), due to their extreme opacity. At most optical wavelengths, however, laser photons are not absorbed but merely scattered out of the beam, and thus eventually escape the cloud via multiple scattering, producing distinctive extended space- and time-dependent patterns which are, in essence, the cloud's radiative Green functions. These Green functions, essentially 'movies' of the time evolution of the spatial distribution of escaping light, are the primary data products of a new type of lidar: Wide Angle Imaging Lidar (WAIL). WAIL data can be used to infer both optical depth and physical thickness of clouds, and hence the cloud liquid water content. The instrumental challenge is to accommodate a radiance field varying over many orders of magnitude and changing over widely varying time-scales. Our implementation uses a high-speed microchannel plate/crossed delay line imaging detector system with a 60-degree full-angle field of view, and a 532 nm doubled Nd:YAG laser. Nighttime field experiments testing various solutions to this problem show excellent agreement with diffusion theory, and retrievals yield plausible values for the optical and geometrical parameters of the observed cloud decks.

Impact of large field angles on the requirements for deformable mirror in imaging satellites

Science.gov (United States)

Kim, Jae Jun; Mueller, Mark; Martinez, Ty; Agrawal, Brij

2018-04-01

For certain imaging satellite missions, a large aperture with wide field-of-view is needed. In order to achieve diffraction limited performance, the mirror surface Root Mean Square (RMS) error has to be less than 0.05 waves. In the case of visible light, it has to be less than 30 nm. This requirement is difficult to meet as the large aperture will need to be segmented in order to fit inside a launch vehicle shroud. To reduce this requirement and to compensate for the residual wavefront error, Micro-Electro-Mechanical System (MEMS) deformable mirrors can be considered in the aft optics of the optical system. MEMS deformable mirrors are affordable and consume low power, but are small in size. Due to the major reduction in pupil size for the deformable mirror, the effective field angle is magnified by the diameter ratio of the primary and deformable mirror. For wide field of view imaging, the required deformable mirror correction is field angle dependant, impacting the required parameters of a deformable mirror such as size, number of actuators, and actuator stroke. In this paper, a representative telescope and deformable mirror system model is developed and the deformable mirror correction is simulated to study the impact of the large field angles in correcting a wavefront error using a deformable mirror in the aft optics.

Rotation Estimation for Wide-Angle Inverse Synthetic Aperture Radar Imaging

Directory of Open Access Journals (Sweden)

Wei Zhou

2016-01-01

Full Text Available To present focused ISAR imaging results in the homogenous range and cross-range domain, an integrated scheme is proposed to estimate both the targets equivalent rotational velocity (RV and rotational center (RC. The RV estimation is improved by radial projection combined with keystone processing, and then the RC is estimated through image entropy minimization. Finally, delicate imaging results may be obtained for wide-angle scenarios. Experiment results are provided to demonstrate the effectiveness of the proposed method.

Enterprise-wide PACS: beyond radiology, an architecture to manage all medical images.

Science.gov (United States)

Bandon, David; Lovis, Christian; Geissbühler, Antoine; Vallée, Jean-Paul

2005-08-01

Picture archiving and communication systems (PACS) have the vocation to manage all medical images acquired within the hospital. To address the various situations encountered in the imaging specialties, the traditional architecture used for the radiology department has to evolve. We present our preliminarily results toward an enterprise-wide PACS intended to support all kind of image production in medicine, from biomolecular images to whole-body pictures. Our solution is based on an existing radiologic PACS system from which images are distributed through an electronic patient record to all care facilities. This platform is enriched with a flexible integration framework supporting digital image communication in medicine (DICOM) and DICOM-XML formats. In addition, a generic workflow engine highly customizable is used to drive work processes. Echocardiology; hematology; ear, nose, and throat; and dermatology, including wounds, follow-up is the first implemented extensions outside of radiology. We also propose a global strategy for further developments based on three possible architectures for an enterprise-wide PACS.

Novel X-ray telescopes for wide-field X-ray monitoring

International Nuclear Information System (INIS)

Hudec, R.; Inneman, A.; Pina, L.; Sveda, L.

2005-01-01

We report on fully innovative very wide-field of view X-ray telescopes with high sensitivity as well as large field of view. The prototypes are very promising, allowing the proposals for space projects with very wide-field Lobster-eye X-ray optics to be considered. The novel telescopes will monitor the sky with unprecedented sensitivity and angular resolution of order of 1 arcmin. They are expected to contribute essentially to study and to understand various astrophysical objects such as AGN, SNe, Gamma-ray bursts (GRBs), X-ray flashes (XRFs), galactic binary sources, stars, CVs, X-ray novae, various transient sources, etc. The Lobster optics based X-ray All Sky Monitor is capable to detect around 20 GRBs and 8 XRFs yearly and this will surely significantly contribute to the related science

Low field magnetic resonance imaging

Science.gov (United States)

Pines, Alexander; Sakellariou, Dimitrios; Meriles, Carlos A.; Trabesinger, Andreas H.

2010-07-13

A method and system of magnetic resonance imaging does not need a large homogenous field to truncate a gradient field. Spatial information is encoded into the spin magnetization by allowing the magnetization to evolve in a non-truncated gradient field and inducing a set of 180 degree rotations prior to signal acquisition.

Techniques for depth-resolved imaging through turbid media including coherence-gated imaging

International Nuclear Information System (INIS)

Dunsby, C; French, P M W

2003-01-01

This article aims to review the panoply of techniques for realising optical imaging through turbid media such as biological tissue. It begins by briefly discussing optical scattering and outlines the various approaches that have been developed to image through scattering media including spatial filtering, time-gated imaging and coherence-based techniques. The discussion includes scanning and wide-field techniques and concentrates on techniques to discriminate in favour of unscattered ballistic light although imaging with scattered light is briefly reviewed. Wide-field coherence-gated imaging techniques are discussed in some detail with particular emphasis placed on techniques to achieve real-time high-resolution three-dimensional imaging including through turbid media, providing rapid whole-field acquisition and high depth and transverse spatial resolution images. (topical review)

X-ray astronomy 2000: Wide field X-ray monitoring with lobster-eye telescopes

International Nuclear Information System (INIS)

Inneman, A.; Hudec, R.; Pina, L.; Gorenstein, P.

2001-01-01

The recently available first prototypes of innovative very wide field X-ray telescopes of Lobster-Eye type confirm the feasibility to develop such flight instruments in a near future. These devices are expected to allow very wide field (more than 1000 square degrees) monitoring of the sky in X-rays (up to 10 keV and perhaps even more) with faint limits. We will discuss the recent status of the development of very wide field X-ray telescopes as well as related scientific questions including expected major contributions such as monitoring and study of X-ray afterglows of Gamma Ray Bursts

Single-shot imaging with higher-dimensional encoding using magnetic field monitoring and concomitant field correction.

Science.gov (United States)

Testud, Frederik; Gallichan, Daniel; Layton, Kelvin J; Barmet, Christoph; Welz, Anna M; Dewdney, Andrew; Cocosco, Chris A; Pruessmann, Klaas P; Hennig, Jürgen; Zaitsev, Maxim

2015-03-01

PatLoc (Parallel Imaging Technique using Localized Gradients) accelerates imaging and introduces a resolution variation across the field-of-view. Higher-dimensional encoding employs more spatial encoding magnetic fields (SEMs) than the corresponding image dimensionality requires, e.g. by applying two quadratic and two linear spatial encoding magnetic fields to reconstruct a 2D image. Images acquired with higher-dimensional single-shot trajectories can exhibit strong artifacts and geometric distortions. In this work, the source of these artifacts is analyzed and a reliable correction strategy is derived. A dynamic field camera was built for encoding field calibration. Concomitant fields of linear and nonlinear spatial encoding magnetic fields were analyzed. A combined basis consisting of spherical harmonics and concomitant terms was proposed and used for encoding field calibration and image reconstruction. A good agreement between the analytical solution for the concomitant fields and the magnetic field simulations of the custom-built PatLoc SEM coil was observed. Substantial image quality improvements were obtained using a dynamic field camera for encoding field calibration combined with the proposed combined basis. The importance of trajectory calibration for single-shot higher-dimensional encoding is demonstrated using the combined basis including spherical harmonics and concomitant terms, which treats the concomitant fields as an integral part of the encoding. © 2014 Wiley Periodicals, Inc.

Parfocal wide field near infrared grism design and fabrication for WFIRST

Data.gov (United States)

National Aeronautics and Space Administration — WFIRST will have Hubble image quality with 100x the field area of HST/WFC3. It requires both imaging and, working in the same optical train, a grism allowing...

Wide-field time-correlated single photon counting (TCSPC) microscopy with time resolution below the frame exposure time

Energy Technology Data Exchange (ETDEWEB)

Hirvonen, Liisa M. [Department of Physics, King' s College London, Strand, London WC2R 2LS (United Kingdom); Petrášek, Zdeněk [Max Planck Institute of Biochemistry, Department of Cellular and Molecular Biophysics, Am Klopferspitz 18, D-82152 Martinsried (Germany); Suhling, Klaus, E-mail: klaus.suhling@kcl.ac.uk [Department of Physics, King' s College London, Strand, London WC2R 2LS (United Kingdom)

2015-07-01

Fast frame rate CMOS cameras in combination with photon counting intensifiers can be used for fluorescence imaging with single photon sensitivity at kHz frame rates. We show here how the phosphor decay of the image intensifier can be exploited for accurate timing of photon arrival well below the camera exposure time. This is achieved by taking ratios of the intensity of the photon events in two subsequent frames, and effectively allows wide-field TCSPC. This technique was used for measuring decays of ruthenium compound Ru(dpp) with lifetimes as low as 1 μs with 18.5 μs frame exposure time, including in living HeLa cells, using around 0.1 μW excitation power. We speculate that by using an image intensifier with a faster phosphor decay to match a higher camera frame rate, photon arrival time measurements on the nanosecond time scale could well be possible.

Wide-band IR imaging in the NIR-MIR-FIR regions for in situ analysis of frescoes

Science.gov (United States)

Daffara, C.; Pezzati, L.; Ambrosini, D.; Paoletti, D.; Di Biase, R.; Mariotti, P. I.; Frosinini, C.

2011-06-01

Imaging methods offer several advantages in the field of conservation allowing to perform non-invasive inspection of works of art. In particular, non-invasive techniques based on imaging in different infrared (IR) regions are widely used for the investigation of paintings. Using radiation beyond the visible range, different characteristics of the inspected artwork may be revealed according to the bandwidth acquired. In this paper we present the recent results of a joint project among the two research institutes DIMEG and CNR-INO, and the restoration facility Opificio delle Pietre Dure, concerning the wide-band integration of IR imaging techniques, in the spectral ranges NIR 0.8-2.5 μm, MIR 3-5 μm, and FIR 8-12 μm, for in situ analysis of artworks. A joint, multi-mode use of reflection and thermal bands is proposed for the diagnostics of mural paintings, and it is demonstrated to be an effective tool in inspecting the layered structure. High resolution IR reflectography and, to a greater extent, IR imaging in the 3-5 μm band, are effectively used to characterize the superficial layer of the fresco and to analyze the stratigraphy of different pictorial layers. IR thermography in the 8-12 μm band is used to characterize the support deep structure. The integration of all the data provides a multi- layered and multi-spectral representation of the fresco that yields a comprehensive analysis.

Study of Wide Swath Synthetic Aperture Ladar Imaging Techology

Directory of Open Access Journals (Sweden)

Zhang Keshu

2017-02-01

Full Text Available Combining synthetic-aperture imaging and coherent-light detection technology, the weak signal identification capacity of Synthetic Aperture Ladar (SAL reaches the photo level, and the image resolution exceeds the diffraction limit of the telescope to obtain high-resolution images irrespective to ranges. This paper introduces SAL, including the development path, technology characteristics, and the restriction of imaging swath. On the basis of this, we propose to integrate the SAL technology for extending its swath. By analyzing the scanning-operation mode and the signal model, the paper explicitly proposes that the former mode will be the developmental trend of the SAL technology. This paper also introduces the flight demonstrations of the SAL and the imaging results of remote targets, showing the potential of the SAL in long-range, high-resolution, and scanning-imaging applications. The technology and the theory of the scanning mode of SAL compensates for the defects related to the swath and operation efficiency of the current SAL. It provides scientific foundation for the SAL system applied in wide swath, high resolution earth observation, and the ISAL system applied in space-targets imaging.

World-Wide Web Tools for Locating Planetary Images

Science.gov (United States)

Kanefsky, Bob; Deiss, Ron (Technical Monitor)

1995-01-01

The explosive growth of the World-Wide Web (WWW) in the past year has made it feasible to provide interactive graphical tools to assist scientists in locating planetary images. The highest available resolution images of any site of interest can be quickly found on a map or plot, and, if online, displayed immediately on nearly any computer equipped with a color screen, an Internet connection, and any of the free WWW browsers. The same tools may also be of interest to educators, students, and the general public. Image finding tools have been implemented covering most of the solar system: Earth, Mars, and the moons and planets imaged by Voyager. The Mars image-finder, which plots the footprints of all the high-resolution Viking Orbiter images and can be used to display any that are available online, also contains a complete scrollable atlas and hypertext gazetteer to help locating areas. The Earth image-finder is linked to thousands of Shuttle images stored at NASA/JSC, and displays them as red dots on a globe. The Voyager image-finder plots images as dots, by longitude and apparent target size, linked to online images. The locator (URL) for the top-level page is http: //ic-www.arc.nasa.gov/ic/projects/bayes-group/Atlas/. Through the efforts of the Planetary Data System and other organizations, hundreds of thousands of planetary images are now available on CD-ROM, and many of these have been made available on the WWW. However, locating images of a desired site is still problematic, in practice. For example, many scientists studying Mars use digital image maps, which are one third the resolution of Viking Orbiter survey images. When they douse Viking Orbiter images, they often work with photographically printed hardcopies, which lack the flexibility of digital images: magnification, contrast stretching, and other basic image-processing techniques offered by off-the-shelf software. From the perspective of someone working on an experimental image processing technique for

Field Imaging Spectroscopy. Applications in Earthquake Geology

Science.gov (United States)

Ragona, D.; Minster, B.; Rockwell, T. K.; Fialko, Y.; Jussila, J.; Blom, R.

2005-12-01

Field Imaging Spectroscopy in the visible and infrared sections of the spectrum can be used as a technique to assist paleoseismological studies. Submeter range hyperspectral images of paleoseismic excavations can assist the analyisis and interpretation of the earthquake history of a site. They also provide an excellent platform for storage of the stratigraphic and structural information collected from such a site. At the present, most field data are collected descriptively. This greatly enhances the range of information that can be recorded in the field. The descriptions are documented on hand drawn field logs and/or photomosaics constructed from individual photographs. Recently developed portable hyperspectral sensors acquire high-quality spectroscopic information at high spatial resolution (pixel size ~ 0.5 mm at 50 cm) over frequencies ranging from the visible band to short wave infrared. The new data collection and interpretation methodology that we are developing (Field Imaging Spectroscopy) makes available, for the first time, a tool to quantitatively analyze paleoseismic and stratigraphic information. The reflectance spectra of each sub-millimeter portion of the material are stored in a 3-D matrix (hyperspectral cube) that can be analyzed by visual inspection, or by using a large variety of algorithms. The reflectance spectrum is related to the chemical composition and physical properties of the surface therefore hyperspectral images are capable of revealing subtle changes in texture, composition and weathering. For paleoseismic studies, we are primarily interested in distinguishing changes between layers at a given site (spectral stratigraphy) rather than the precise composition of the layers, although this is an added benefit. We have experimented with push-broom (panoramic) portable scanners, and acquired data form portions of fault exposures and cores. These images were processed using well-known imaging processing algorithms, and the results have being

Design drivers for a wide-field multi-object spectrograph for the William Herschel Telescope

NARCIS (Netherlands)

Balcells, Marc; Benn, Chris R.; Carter, David; Dalton, Gavin B.; Trager, Scott C.; Feltzing, Sofia; Verheijen, M.A.W.; Jarvis, Matt; Percival, Will; Abrams, Don C.; Agocs, Tibor; Brown, Anthony G. A.; Cano, Diego; Evans, Chris; Helmi, Amina; Lewis, Ian J.; McLure, Ross; Peletier, Reynier F.; Pérez-Fournon, Ismael; Sharples, Ray M.; Tosh, Ian A. J.; Trujillo, Ignacio; Walton, Nic; Westhall, Kyle B.

Wide-field multi-object spectroscopy is a high priority for European astronomy over the next decade. Most 8-10m telescopes have a small field of view, making 4-m class telescopes a particularly attractive option for wide-field instruments. We present a science case and design drivers for a

Energy weighted x-ray dark-field imaging.

Science.gov (United States)

Pelzer, Georg; Zang, Andrea; Anton, Gisela; Bayer, Florian; Horn, Florian; Kraus, Manuel; Rieger, Jens; Ritter, Andre; Wandner, Johannes; Weber, Thomas; Fauler, Alex; Fiederle, Michael; Wong, Winnie S; Campbell, Michael; Meiser, Jan; Meyer, Pascal; Mohr, Jürgen; Michel, Thilo

2014-10-06

The dark-field image obtained in grating-based x-ray phase-contrast imaging can provide information about the objects' microstructures on a scale smaller than the pixel size even with low geometric magnification. In this publication we demonstrate that the dark-field image quality can be enhanced with an energy-resolving pixel detector. Energy-resolved x-ray dark-field images were acquired with a 16-energy-channel photon-counting pixel detector with a 1 mm thick CdTe sensor in a Talbot-Lau x-ray interferometer. A method for contrast-noise-ratio (CNR) enhancement is proposed and validated experimentally. In measurements, a CNR improvement by a factor of 1.14 was obtained. This is equivalent to a possible radiation dose reduction of 23%.

System description and analysis. Part 1: Feasibility study for helicopter/VTOL wide-angle simulation image generation display system

Science.gov (United States)

1977-01-01

A preliminary design for a helicopter/VSTOL wide angle simulator image generation display system is studied. The visual system is to become part of a simulator capability to support Army aviation systems research and development within the near term. As required for the Army to simulate a wide range of aircraft characteristics, versatility and ease of changing cockpit configurations were primary considerations of the study. Due to the Army's interest in low altitude flight and descents into and landing in constrained areas, particular emphasis is given to wide field of view, resolution, brightness, contrast, and color. The visual display study includes a preliminary design, demonstrated feasibility of advanced concepts, and a plan for subsequent detail design and development. Analysis and tradeoff considerations for various visual system elements are outlined and discussed.

A robust sub-pixel edge detection method of infrared image based on tremor-based retinal receptive field model

Science.gov (United States)

Gao, Kun; Yang, Hu; Chen, Xiaomei; Ni, Guoqiang

2008-03-01

Because of complex thermal objects in an infrared image, the prevalent image edge detection operators are often suitable for a certain scene and extract too wide edges sometimes. From a biological point of view, the image edge detection operators work reliably when assuming a convolution-based receptive field architecture. A DoG (Difference-of- Gaussians) model filter based on ON-center retinal ganglion cell receptive field architecture with artificial eye tremors introduced is proposed for the image contour detection. Aiming at the blurred edges of an infrared image, the subsequent orthogonal polynomial interpolation and sub-pixel level edge detection in rough edge pixel neighborhood is adopted to locate the foregoing rough edges in sub-pixel level. Numerical simulations show that this method can locate the target edge accurately and robustly.

Imaging FTS: A Different Approach to Integral Field Spectroscopy

Directory of Open Access Journals (Sweden)

Laurent Drissen

2014-01-01

Full Text Available Imaging Fourier transform spectroscopy (iFTS is a promising, although technically very challenging, option for wide-field hyperspectral imagery. We present in this paper an introduction to the iFTS concept and its advantages and drawbacks, as well as examples of data obtained with a prototype iFTS, SpIOMM, attached to the 1.6 m telescope of the Observatoire du Mont-Mégantic: emission line ratios in the spiral galaxy NGC 628 and absorption line indices in the giant elliptical M87. We conclude by introducing SpIOMM's successor, SITELLE, which will be installed at the Canada-France-Hawaii Telescope in 2014.

HDR Pathological Image Enhancement Based on Improved Bias Field Correction and Guided Image Filter

Directory of Open Access Journals (Sweden)

Qingjiao Sun

2016-01-01

Full Text Available Pathological image enhancement is a significant topic in the field of pathological image processing. This paper proposes a high dynamic range (HDR pathological image enhancement method based on improved bias field correction and guided image filter (GIF. Firstly, a preprocessing including stain normalization and wavelet denoising is performed for Haematoxylin and Eosin (H and E stained pathological image. Then, an improved bias field correction model is developed to enhance the influence of light for high-frequency part in image and correct the intensity inhomogeneity and detail discontinuity of image. Next, HDR pathological image is generated based on least square method using low dynamic range (LDR image, H and E channel images. Finally, the fine enhanced image is acquired after the detail enhancement process. Experiments with 140 pathological images demonstrate the performance advantages of our proposed method as compared with related work.

Design of wide flat-topped low transverse field solenoid magnet

International Nuclear Information System (INIS)

Jing Xiaobing; Chen Nan; Li Qin

2010-01-01

A wide flat-topped low transverse error field solenoid magnet design for linear induction accelerator is presented. The design features non-uniform winding to reduce field fluctuation due to the magnets' gap, and homogenizer rings within the solenoid to greatly reduce the effects of winding errors. Numerical modeling of several designs for 12 MeV linear induction accelerator (LIA) in China Academy of Engineering Physics has demonstrated that by using these two techniques the magnetic field fluctuations in the accelerator gap can be reduced by 70% and the transverse error field can be reduced by 96.5%. (authors)

Application of stereo-imaging technology to medical field.

Science.gov (United States)

Nam, Kyoung Won; Park, Jeongyun; Kim, In Young; Kim, Kwang Gi

2012-09-01

There has been continuous development in the area of stereoscopic medical imaging devices, and many stereoscopic imaging devices have been realized and applied in the medical field. In this article, we review past and current trends pertaining to the application stereo-imaging technologies in the medical field. We describe the basic principles of stereo vision and visual issues related to it, including visual discomfort, binocular disparities, vergence-accommodation mismatch, and visual fatigue. We also present a brief history of medical applications of stereo-imaging techniques, examples of recently developed stereoscopic medical devices, and patent application trends as they pertain to stereo-imaging medical devices. Three-dimensional (3D) stereo-imaging technology can provide more realistic depth perception to the viewer than conventional two-dimensional imaging technology. Therefore, it allows for a more accurate understanding and analysis of the morphology of an object. Based on these advantages, the significance of stereoscopic imaging in the medical field increases in accordance with the increase in the number of laparoscopic surgeries, and stereo-imaging technology plays a key role in the diagnoses of the detailed morphologies of small biological specimens. The application of 3D stereo-imaging technology to the medical field will help improve surgical accuracy, reduce operation times, and enhance patient safety. Therefore, it is important to develop more enhanced stereoscopic medical devices.

X-ray dark field imaging of human articular cartilage: Possible clinical application to orthopedic surgery

International Nuclear Information System (INIS)

Kunisada, Toshiyuki; Shimao, Daisuke; Sugiyama, Hiroshi; Takeda, Ken; Ozaki, Toshifumi; Ando, Masami

2008-01-01

Despite its convenience and non-invasiveness on daily clinical use, standard X-ray radiography cannot show articular cartilage. We developed a novel type of X-ray dark field imaging (DFI), which forms images only by a refracted beam with very low background illumination. We examined a disarticulated distal femur and a shoulder joint with surrounding soft tissue and skin, both excised from a human cadaver at the BL20B2 synchrotron beamline at SPring-8. The field was 90 mm wide and 90 mm high. Articular cartilage of the disarticulated distal femur was obvious on DFI, but not on standard X-ray images. Furthermore, DFI allowed visualization in situ of articular cartilage of the shoulder while covered with soft tissue and skin. The gross appearance of the articular cartilage on the dissected section of the proximal humerus was identical to the cartilage shown on the DFI image. These results suggested that DFI could provide a clinically accurate method of assessing articular cartilage. Hence, DFI would be a useful imaging tool for diagnosing joint disease such as osteoarthritis

X-ray dark field imaging of human articular cartilage: Possible clinical application to orthopedic surgery

Energy Technology Data Exchange (ETDEWEB)

Kunisada, Toshiyuki [Department of Medical Materials for Musculoskeletal Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558 (Japan); Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558 (Japan)], E-mail: toshi-kunisada@umin.ac.jp; Shimao, Daisuke [Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki 300-2394 (Japan); Sugiyama, Hiroshi [Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), Ibaraki 305-0801 (Japan); Takeda, Ken; Ozaki, Toshifumi [Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558 (Japan); Ando, Masami [Research Institute for Science and Technology, Tokyo University of Science, Chiba 278-8510 (Japan)

2008-12-15

Despite its convenience and non-invasiveness on daily clinical use, standard X-ray radiography cannot show articular cartilage. We developed a novel type of X-ray dark field imaging (DFI), which forms images only by a refracted beam with very low background illumination. We examined a disarticulated distal femur and a shoulder joint with surrounding soft tissue and skin, both excised from a human cadaver at the BL20B2 synchrotron beamline at SPring-8. The field was 90 mm wide and 90 mm high. Articular cartilage of the disarticulated distal femur was obvious on DFI, but not on standard X-ray images. Furthermore, DFI allowed visualization in situ of articular cartilage of the shoulder while covered with soft tissue and skin. The gross appearance of the articular cartilage on the dissected section of the proximal humerus was identical to the cartilage shown on the DFI image. These results suggested that DFI could provide a clinically accurate method of assessing articular cartilage. Hence, DFI would be a useful imaging tool for diagnosing joint disease such as osteoarthritis.

Image restoration from non-uniform magnetic field influence for direct Fourier NMR imaging

International Nuclear Information System (INIS)

Sekihara, K.; Kuroda, M.; Kohno, H.

1984-01-01

A new technique is proposed for NMR image restoration from the influence of main magnetic field non-uniformities. This technique is applicable to direct Fourier NMR imaging. The mathematical basis and details of this technique are fully described. Modification to include image restoration from non-linear field gradient influence is also presented. Computer simulation demonstrates the effectiveness of this technique for both Fourier zeugmatography and spin-warp imaging. (author)

Ultra-fast bright field and fluorescence imaging of the dynamics of micrometer-sized objects

Science.gov (United States)

Chen, Xucai; Wang, Jianjun; Versluis, Michel; de Jong, Nico; Villanueva, Flordeliza S.

2013-06-01

High speed imaging has application in a wide area of industry and scientific research. In medical research, high speed imaging has the potential to reveal insight into mechanisms of action of various therapeutic interventions. Examples include ultrasound assisted thrombolysis, drug delivery, and gene therapy. Visual observation of the ultrasound, microbubble, and biological cell interaction may help the understanding of the dynamic behavior of microbubbles and may eventually lead to better design of such delivery systems. We present the development of a high speed bright field and fluorescence imaging system that incorporates external mechanical waves such as ultrasound. Through collaborative design and contract manufacturing, a high speed imaging system has been successfully developed at the University of Pittsburgh Medical Center. We named the system "UPMC Cam," to refer to the integrated imaging system that includes the multi-frame camera and its unique software control, the customized modular microscope, the customized laser delivery system, its auxiliary ultrasound generator, and the combined ultrasound and optical imaging chamber for in vitro and in vivo observations. This system is capable of imaging microscopic bright field and fluorescence movies at 25 × 106 frames per second for 128 frames, with a frame size of 920 × 616 pixels. Example images of microbubble under ultrasound are shown to demonstrate the potential application of the system.

Reducing Field Distortion in Magnetic Resonance Imaging

Science.gov (United States)

Eom, Byeong Ho; Penanen, Konstantin; Hahn, Inseob

2010-01-01

A concept for a magnetic resonance imaging (MRI) system that would utilize a relatively weak magnetic field provides for several design features that differ significantly from the corresponding features of conventional MRI systems. Notable among these features are a magnetic-field configuration that reduces (relative to the conventional configuration) distortion and blurring of the image, the use of a superconducting quantum interference device (SQUID) magnetometer as the detector, and an imaging procedure suited for the unconventional field configuration and sensor. In a typical application of MRI, a radio-frequency pulse is used to excite precession of the magnetic moments of protons in an applied magnetic field, and the decaying precession is detected for a short time following the pulse. The precession occurs at a resonance frequency proportional to the strengths of the magnetic field and the proton magnetic moment. The magnetic field is configured to vary with position in a known way; hence, by virtue of the aforesaid proportionality, the resonance frequency varies with position in a known way. In other words, position is encoded as resonance frequency. MRI using magnetic fields weaker than those of conventional MRI offers several advantages, including cheaper and smaller equipment, greater compatibility with metallic objects, and higher image quality because of low susceptibility distortion and enhanced spin-lattice-relaxation- time contrast. SQUID MRI is being developed into a practical MRI method for applied magnetic flux densities of the order of only 100 T

Very low field magnetic resonance imaging

International Nuclear Information System (INIS)

Herreros, Quentin

2013-01-01

The aim of this thesis is to perform Magnetic Resonance Imaging at very low field (from 1 mT to 10 mT). A new kind of sensor called 'mixed sensor' has been used to achieve a good detectivity at low frequencies. Combining a superconducting loop and a giant magnetoresistance, those detectors have a competitive equivalent field noise compared to existing devices (Tuned coils, SQUIDs and Atomic Magnetometers). They have been combined with flux transformers to increase the coupling between the sample and the sensor. A complete study has been performed to adapt it to mixed sensors and then maximize the gain. This set has been incorporated in an existing small MRI device to test its robustness in real conditions. In parallel, several MRI sequences (GE, SE, FLASH, EPI,...) have been integrated and adapted to very low field requirements. They have been used to perform in-vivo three dimensional imaging and relaxometry studies on well known products to test their reliability. Finally, a larger setup adapted for full-head imaging has been designed and built to perform images on a larger working volume. (author) [fr

Pelvic endometriosis: a comparison between low-field (0.2 T) and high-field (1.5 T) magnetic resonance imaging

Energy Technology Data Exchange (ETDEWEB)

Minaif, Karine; Ajzen, Sergio [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Dept. of Imaging Diagnosis]. E-mail: kminaif@uol.com.br; Shigueoka, David Carlos; Minami, Cintia Cristina Satie; Sales, Danilo Moulin; Szejnfeld, Jacob [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Dept. of Imaging Diagnosis. Unit of Abdomen; Ruano, Jose Maria Cordeiro [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Dept. of General Gynecology. Sector of Videlaparoscopy; Noguti, Alberto Sinhiti [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Dept. of General Gynecology

2008-11-15

Objective: to compare low-field (0.2 T) with high-field (1.5 T) magnetic resonance imaging in the assessment of pelvic endometriosis and adenomyosis. Materials and methods: twenty-seven female patients with clinically suspected endometriosis were prospectively evaluated by means of high-field and low-field magnetic resonance imaging. The reading of the images was performed by a single radiologist, initiating by the low-field, followed by the high-field images. High-field magnetic resonance imaging was utilized as the golden-standard. Results: among the 27 patients included in the present study, 18 (66.7%) had some type of lesion suggesting the presence of endometriosis demonstrated at high-field images. In 14 of these patients the diagnosis was correctly established by low-field magnetic resonance imaging. Endometriomas, tubal lesions, and endometriotic foci > 7 mm identified at the high-field images were also identified at low-field images with 100% accuracy, sensitivity and specificity. Among the nine patients diagnosed with adenomyosis by high-field images, eight were correctly diagnosed by low-field images with 88.9% accuracy, specificity and sensitivity. Conclusion: low-field magnetic resonance imaging demonstrated a low sensitivity in the detection of small endometriotic foci, high sensitivity in the detection of endometriomas and large endometriotic foci, and high accuracy in the detection of adenomyosis when compared with high-field magnetic resonance imaging. (author)

Pelvic endometriosis: a comparison between low-field (0.2 T) and high-field (1.5 T) magnetic resonance imaging

International Nuclear Information System (INIS)

Minaif, Karine; Ajzen, Sergio; Shigueoka, David Carlos; Minami, Cintia Cristina Satie; Sales, Danilo Moulin; Szejnfeld, Jacob; Ruano, Jose Maria Cordeiro; Noguti, Alberto Sinhiti

2008-01-01

Objective: to compare low-field (0.2 T) with high-field (1.5 T) magnetic resonance imaging in the assessment of pelvic endometriosis and adenomyosis. Materials and methods: twenty-seven female patients with clinically suspected endometriosis were prospectively evaluated by means of high-field and low-field magnetic resonance imaging. The reading of the images was performed by a single radiologist, initiating by the low-field, followed by the high-field images. High-field magnetic resonance imaging was utilized as the golden-standard. Results: among the 27 patients included in the present study, 18 (66.7%) had some type of lesion suggesting the presence of endometriosis demonstrated at high-field images. In 14 of these patients the diagnosis was correctly established by low-field magnetic resonance imaging. Endometriomas, tubal lesions, and endometriotic foci > 7 mm identified at the high-field images were also identified at low-field images with 100% accuracy, sensitivity and specificity. Among the nine patients diagnosed with adenomyosis by high-field images, eight were correctly diagnosed by low-field images with 88.9% accuracy, specificity and sensitivity. Conclusion: low-field magnetic resonance imaging demonstrated a low sensitivity in the detection of small endometriotic foci, high sensitivity in the detection of endometriomas and large endometriotic foci, and high accuracy in the detection of adenomyosis when compared with high-field magnetic resonance imaging. (author)

THz Imaging by a Wide-band Compact FEL

CERN Document Server

Uk Jeong Young; Cheol Lee Byung; Hee-Park, S

2004-01-01

We have developed a laboratory-scale users facility with a compact THz FEL. The FEL operates in the wide wavelength range of 100–1200 μm, which corresponds to 0.3-3 THz. THz radiation from the FEL shows well collimated Gaussian spatial distribution and narrow spectral width of 0.3 μm, which is Fourier transform limited by the estimated pulse duration of 20 ps. The main application of the FEL is THz imaging for bio-medical researches. We are developing THz imaging techniques by 2-D scanning, single pulse capturing with the electro-optic method, and 3-D holography. High power, coherent, and pulsed feature of the FEL radiation is expected to show much better performance in advanced THz imaging of 3-D tomography by comparing with incoherent and weak THz sources. By controlling the optical delay between reference beam and scattered light from an object, we can get its 3-D tomography by the holograms. The coherent and pulse length of the FEL beam is measured to be 3-6 mm. In this paper we will show a...

Target-oriented retrieval of subsurface wave fields - Pushing the resolution limits in seismic imaging

Science.gov (United States)

Vasconcelos, Ivan; Ozmen, Neslihan; van der Neut, Joost; Cui, Tianci

2017-04-01

Travelling wide-bandwidth seismic waves have long been used as a primary tool in exploration seismology because they can probe the subsurface over large distances, while retaining relatively high spatial resolution. The well-known Born resolution limit often seems to be the lower bound on spatial imaging resolution in real life examples. In practice, data acquisition cost, time constraints and other factors can worsen the resolution achieved by wavefield imaging. Could we obtain images whose resolution beats the Born limits? Would it be practical to achieve it, and what are we missing today to achieve this? In this talk, we will cover aspects of linear and nonlinear seismic imaging to understand elements that play a role in obtaining "super-resolved" seismic images. New redatuming techniques, such as the Marchenko method, enable the retrieval of subsurface fields that include multiple scattering interactions, while requiring relatively little knowledge of model parameters. Together with new concepts in imaging, such as Target-Enclosing Extended Images, these new redatuming methods enable new targeted imaging frameworks. We will make a case as to why target-oriented approaches to reconstructing subsurface-domain wavefields from surface data may help in increasing the resolving power of seismic imaging, and in pushing the limits on parameter estimation. We will illustrate this using a field data example. Finally, we will draw connections between seismic and other imaging modalities, and discuss how this framework could be put to use in other applications

High-resolution small field-of-view magnetic resonance image acquisition system using a small planar coil and a pneumatic manipulator in an open MRI scanner.

Science.gov (United States)

Miki, Kohei; Masamune, Ken

2015-10-01

Low-field open magnetic resonance imaging (MRI) is frequently used for performing image-guided neurosurgical procedures. Intraoperative magnetic resonance (MR) images are useful for tracking brain shifts and verifying residual tumors. However, it is difficult to precisely determine the boundary of the brain tumors and normal brain tissues because the MR image resolution is low, especially when using a low-field open MRI scanner. To overcome this problem, a high-resolution MR image acquisition system was developed and tested. An MR-compatible manipulator with pneumatic actuators containing an MR signal receiver with a small radiofrequency (RF) coil was developed. The manipulator had five degrees of freedom for position and orientation control of the RF coil. An 8-mm planar RF coil with resistance and inductance of 2.04 [Formula: see text] and 1.00 [Formula: see text] was attached to the MR signal receiver at the distal end of the probe. MR images of phantom test devices were acquired using the MR signal receiver and normal head coil for signal-to-noise ratio (SNR) testing. The SNR of MR images acquired using the MR signal receiver was 8.0 times greater than that of MR images acquired using the normal head coil. The RF coil was moved by the manipulator, and local MR images of a phantom with a 2-mm grid were acquired using the MR signal receiver. A wide field-of-view MR image was generated from a montage of local MR images. A small field-of-view RF system with a pneumatic manipulator was integrated in a low-field MRI scanner to allow acquisition of both wide field-of-view and high-resolution MR images. This system is promising for image-guided neurosurgery as it may allow brain tumors to be observed more clearly and removed precisely.

Anti-Stokes effect CCD camera and SLD based optical coherence tomography for full-field imaging in the 1550nm region

Science.gov (United States)

Kredzinski, Lukasz; Connelly, Michael J.

2012-06-01

Full-field Optical coherence tomography is an en-face interferometric imaging technology capable of carrying out high resolution cross-sectional imaging of the internal microstructure of an examined specimen in a non-invasive manner. The presented system is based on competitively priced optical components available at the main optical communications band located in the 1550 nm region. It consists of a superluminescent diode and an anti-stokes imaging device. The single mode fibre coupled SLD was connected to a multi-mode fibre inserted into a mode scrambler to obtain spatially incoherent illumination, suitable for OCT wide-field modality in terms of crosstalk suppression and image enhancement. This relatively inexpensive system with moderate resolution of approximately 24um x 12um (axial x lateral) was constructed to perform a 3D cross sectional imaging of a human tooth. To our knowledge this is the first 1550 nm full-field OCT system reported.

Directional x-ray dark-field imaging of strongly ordered systems

Science.gov (United States)

Jensen, Torben Haugaard; Bech, Martin; Zanette, Irene; Weitkamp, Timm; David, Christian; Deyhle, Hans; Rutishauser, Simon; Reznikova, Elena; Mohr, Jürgen; Feidenhans'L, Robert; Pfeiffer, Franz

2010-12-01

Recently a novel grating based x-ray imaging approach called directional x-ray dark-field imaging was introduced. Directional x-ray dark-field imaging yields information about the local texture of structures smaller than the pixel size of the imaging system. In this work we extend the theoretical description and data processing schemes for directional dark-field imaging to strongly scattering systems, which could not be described previously. We develop a simple scattering model to account for these recent observations and subsequently demonstrate the model using experimental data. The experimental data includes directional dark-field images of polypropylene fibers and a human tooth slice.

Electric Potential and Electric Field Imaging with Applications

Science.gov (United States)

Generazio, Ed

2016-01-01

The technology and techniques for remote quantitative imaging of electrostatic potentials and electrostatic fields in and around objects and in free space is presented. Electric field imaging (EFI) technology may be applied to characterize intrinsic or existing electric potentials and electric fields, or an externally generated electrostatic field may be used for (illuminating) volumes to be inspected with EFI. The baseline sensor technology, electric field sensor (e-sensor), and its construction, optional electric field generation (quasistatic generator), and current e-sensor enhancements (ephemeral e-sensor) are discussed. Demonstrations for structural, electronic, human, and memory applications are shown. This new EFI capability is demonstrated to reveal characterization of electric charge distribution, creating a new field of study that embraces areas of interest including electrostatic discharge mitigation, crime scene forensics, design and materials selection for advanced sensors, dielectric morphology of structures, inspection of containers, inspection for hidden objects, tether integrity, organic molecular memory, and medical diagnostic and treatment efficacy applications such as cardiac polarization wave propagation and electromyography imaging.

Wide-Field Optic for Autonomous Acquisition of Laser Link

Science.gov (United States)

Page, Norman A.; Charles, Jeffrey R.; Biswas, Abhijit

2011-01-01

An innovation reported in Two-Camera Acquisition and Tracking of a Flying Target, NASA Tech Briefs, Vol. 32, No. 8 (August 2008), p. 20, used a commercial fish-eye lens and an electronic imaging camera for initially locating objects with subsequent handover to an actuated narrow-field camera. But this operated against a dark-sky background. An improved solution involves an optical design based on custom optical components for the wide-field optical system that directly addresses the key limitations in acquiring a laser signal from a moving source such as an aircraft or a spacecraft. The first challenge was to increase the light collection entrance aperture diameter, which was approximately 1 mm in the first prototype. The new design presented here increases this entrance aperture diameter to 4.2 mm, which is equivalent to a more than 16 times larger collection area. One of the trades made in realizing this improvement was to restrict the field-of-view to +80 deg. elevation and 360 azimuth. This trade stems from practical considerations where laser beam propagation over the excessively high air mass, which is in the line of sight (LOS) at low elevation angles, results in vulnerability to severe atmospheric turbulence and attenuation. An additional benefit of the new design is that the large entrance aperture is maintained even at large off-axis angles when the optic is pointed at zenith. The second critical limitation for implementing spectral filtering in the design was tackled by collimating the light prior to focusing it onto the focal plane. This allows the placement of the narrow spectral filter in the collimated portion of the beam. For the narrow band spectral filter to function properly, it is necessary to adequately control the range of incident angles at which received light intercepts the filter. When this angle is restricted via collimation, narrower spectral filtering can be implemented. The collimated beam (and the filter) must be relatively large to

3D reconstruction based on light field images

Science.gov (United States)

Zhu, Dong; Wu, Chunhong; Liu, Yunluo; Fu, Dongmei

2018-04-01

This paper proposed a method of reconstructing three-dimensional (3D) scene from two light field images capture by Lytro illium. The work was carried out by first extracting the sub-aperture images from light field images and using the scale-invariant feature transform (SIFT) for feature registration on the selected sub-aperture images. Structure from motion (SFM) algorithm is further used on the registration completed sub-aperture images to reconstruct the three-dimensional scene. 3D sparse point cloud was obtained in the end. The method shows that the 3D reconstruction can be implemented by only two light field camera captures, rather than at least a dozen times captures by traditional cameras. This can effectively solve the time-consuming, laborious issues for 3D reconstruction based on traditional digital cameras, to achieve a more rapid, convenient and accurate reconstruction.

Field Sampling from a Segmented Image

CSIR Research Space (South Africa)

Debba, Pravesh

2008-06-01

Full Text Available This paper presents a statistical method for deriving the optimal prospective field sampling scheme on a remote sensing image to represent different categories in the field. The iterated conditional modes algorithm (ICM) is used for segmentation...

Chromophoric Dissolved Organic Matter and Dissolved Organic Carbon from Sea-Viewing Wide Field-of-View Sensor (SeaWiFS), Moderate Resolution Imaging Spectroradiometer (MODIS) and MERIS Sensors: Case Study for the Northern Gulf of Mexico

OpenAIRE

Blake A. Schaeffer; Thomas S. Bianchi; Eurico J. D'Sa; Christopher L. Osburn; Nazanin Chaichi Tehrani

2013-01-01

Empirical band ratio algorithms for the estimation of colored dissolved organic matter (CDOM) and dissolved organic carbon (DOC) for Sea-viewing Wide Field-of-view Sensor (SeaWiFS), Moderate Resolution Imaging Spectroradiometer (MODIS) and MERIS ocean color sensors were assessed and developed for the northern Gulf of Mexico. Match-ups between in situ measurements of CDOM absorption coefficients at 412 nm (aCDOM(412)) with that derived from SeaWiFS were examined using two previously reported r...

A Wide-Field Fluorescence Microscope Extension for Ultrafast Screening of One-Bead One-Compound Libraries Using a Spectral Image Subtraction Approach.

Science.gov (United States)

Heusermann, Wolf; Ludin, Beat; Pham, Nhan T; Auer, Manfred; Weidemann, Thomas; Hintersteiner, Martin

2016-05-09

The increasing involvement of academic institutions and biotech companies in drug discovery calls for cost-effective methods to identify new bioactive molecules. Affinity-based on-bead screening of combinatorial one-bead one-compound libraries combines a split-mix synthesis design with a simple protein binding assay operating directly at the bead matrix. However, one bottleneck for academic scale on-bead screening is the unavailability of a cheap, automated, and robust screening platform that still provides a quantitative signal related to the amount of target protein binding to individual beads for hit bead ranking. Wide-field fluorescence microscopy has long been considered unsuitable due to significant broad spectrum autofluorescence of the library beads in conjunction with low detection sensitivity. Herein, we demonstrate how such a standard microscope equipped with LED-based excitation and a modern CMOS camera can be successfully used for selecting hit beads. We show that the autofluorescence issue can be overcome by an optical image subtraction approach that yields excellent signal-to-noise ratios for the detection of bead-associated target proteins. A polymer capillary attached to a semiautomated bead-picking device allows the operator to efficiently isolate individual hit beads in less than 20 s. The system can be used for ultrafast screening of >200,000 bead-bound compounds in 1.5 h, thereby making high-throughput screening accessible to a wider group within the scientific community.

The Receiver System for the Ooty Wide Field Array

Indian Academy of Sciences (India)

The legacy Ooty Radio Telescope (ORT) is being reconfigured as a 264-element synthesis telescope, called the Ooty Wide Field Array (OWFA). Its antenna elements are the contiguous 1.92 m sections of the parabolic cylinder. It will operate in a 38-MHz frequency band centred at 326.5 MHz and will be equipped with a ...

LOW-FREQUENCY IMAGING OF FIELDS AT HIGH GALACTIC LATITUDE WITH THE MURCHISON WIDEFIELD ARRAY 32 ELEMENT PROTOTYPE

Energy Technology Data Exchange (ETDEWEB)

Williams, Christopher L.; Hewitt, Jacqueline N.; Levine, Alan M. [MIT Kavli Institute for Astrophysics and Space Research, Cambridge, MA (United States); De Oliveira-Costa, Angelica; Hernquist, Lars L.; Bernardi, Gianni [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA (United States); Bowman, Judd D. [School of Earth and Space Exploration, Arizona State University, Tempe, AZ (United States); Briggs, Frank H. [Research School of Astronomy and Astrophysics, The Australian National University, Canberra (Australia); Gaensler, B. M.; Mitchell, Daniel A.; Subrahmanyan, Ravi; Sadler, Elaine M. [ARC Centre of Excellence for All-sky Astrophysics (CAASTRO) (Australia); Morales, Miguel F. [Department of Physics, University of Washington, Seattle, WA (United States); Sethi, Shiv K. [Raman Research Institute, Bangalore (India); Arcus, Wayne; Crosse, Brian W. [International Centre for Radio Astronomy Research, Curtin University, Perth (Australia); Barnes, David G. [Center for Astrophysics and Supercomputing, Swinburne University of Technology, Melbourne (Australia); Bunton, John D. [CSIRO Astronomy and Space Science, Epping (Australia); Cappallo, Roger C.; Corey, Brian E., E-mail: clmw@mit.edu [MIT Haystack Observatory, Westford, MA (United States); and others

2012-08-10

The Murchison Widefield Array (MWA) is a new low-frequency, wide-field-of-view radio interferometer under development at the Murchison Radio-astronomy Observatory in Western Australia. We have used a 32 element MWA prototype interferometer (MWA-32T) to observe two 50 Degree-Sign diameter fields in the southern sky, covering a total of {approx}2700 deg{sup 2}, in order to evaluate the performance of the MWA-32T, to develop techniques for epoch of reionization experiments, and to make measurements of astronomical foregrounds. We developed a calibration and imaging pipeline for the MWA-32T, and used it to produce {approx}15' angular resolution maps of the two fields in the 110-200 MHz band. We perform a blind source extraction using these confusion-limited images, and detect 655 sources at high significance with an additional 871 lower significance source candidates. We compare these sources with existing low-frequency radio surveys in order to assess the MWA-32T system performance, wide-field analysis algorithms, and catalog quality. Our source catalog is found to agree well with existing low-frequency surveys in these regions of the sky and with statistical distributions of point sources derived from Northern Hemisphere surveys; it represents one of the deepest surveys to date of this sky field in the 110-200 MHz band.

Ultra high field magnetic resonance imaging

International Nuclear Information System (INIS)

Lethimonnier, F.; Vedrine, P.

2007-01-01

Understanding human brain function, brain development and brain dysfunction is one of the great challenges of the twenty first century. Biomedical imaging has now run up against a number of technical constraints that are exposing limits to its potential. In order to overcome the current limits to high-field magnetic resonance cerebral imaging (MRI) and unleash its fullest potential, the Cea has built NeuroSpin, an ultra-high-field neuroimaging facility at its Saclay centre (in the Essonne). NeuroSpin already boasts three fully operational MRI systems. The first is a 3-tesla high-field system and the second is a very-high-field 7-tesla system, both of which are dedicated to clinical studies and investigations in humans, while the third is an ultra-high-field 17.65-tesla system designed for studies on small animals. In 2011, NeuroSpin will be commissioning an 11.7-tesla ultra-high-field system of unprecedented power that is designed for research on human subjects. The level of the magnetic field and the scale required will make this joint French-German project to build the magnet a breakthrough in the international arena. (authors)

Classification of high resolution remote sensing image based on geo-ontology and conditional random fields

Science.gov (United States)

Hong, Liang

2013-10-01

The availability of high spatial resolution remote sensing data provides new opportunities for urban land-cover classification. More geometric details can be observed in the high resolution remote sensing image, Also Ground objects in the high resolution remote sensing image have displayed rich texture, structure, shape and hierarchical semantic characters. More landscape elements are represented by a small group of pixels. Recently years, the an object-based remote sensing analysis methodology is widely accepted and applied in high resolution remote sensing image processing. The classification method based on Geo-ontology and conditional random fields is presented in this paper. The proposed method is made up of four blocks: (1) the hierarchical ground objects semantic framework is constructed based on geoontology; (2) segmentation by mean-shift algorithm, which image objects are generated. And the mean-shift method is to get boundary preserved and spectrally homogeneous over-segmentation regions ;(3) the relations between the hierarchical ground objects semantic and over-segmentation regions are defined based on conditional random fields framework ;(4) the hierarchical classification results are obtained based on geo-ontology and conditional random fields. Finally, high-resolution remote sensed image data -GeoEye, is used to testify the performance of the presented method. And the experimental results have shown the superiority of this method to the eCognition method both on the effectively and accuracy, which implies it is suitable for the classification of high resolution remote sensing image.

Magnetic resonance imaging: effects of magnetic field strength

International Nuclear Information System (INIS)

Crooks, L.E.; Arakawa, M.; Hoenninger, J.; McCarten, B.; Watts, J.; Kaufman, L.

1984-01-01

Magnetic resonance images of the head, abdomen, and pelvis of normal adult men were obtained using varying magnetic field strength, and measurements of T1 and T2 relaxations and of signal-to-noise (SN) ratios were determined. For any one spin echo sequence, gray/white matter contrast decreases and muscle/fat contrast increases with field. SN levels rise rapidly up to 3.0 kgauss and then change more slowly, actually dropping for muscle. The optimum field for magnetic resonance imaging depends on tissue type, body part, and imaging sequence, so that it does not have a unique value. Magnetic resonance systems that operate in the 3.0-5.0 kgauss range achieve most or all of the gains that can be achieved by higher magnetic fields

Far-field super-resolution imaging of resonant multiples

KAUST Repository

Guo, Bowen

2016-05-20

We demonstrate for the first time that seismic resonant multiples, usually considered as noise, can be used for super-resolution imaging in the far-field region of sources and receivers. Tests with both synthetic data and field data show that resonant multiples can image reflector boundaries with resolutions more than twice the classical resolution limit. Resolution increases with the order of the resonant multiples. This procedure has important applications in earthquake and exploration seismology, radar, sonar, LIDAR (light detection and ranging), and ultrasound imaging, where the multiples can be used to make high-resolution images.

Electric field imaging of single atoms

Science.gov (United States)

Shibata, Naoya; Seki, Takehito; Sánchez-Santolino, Gabriel; Findlay, Scott D.; Kohno, Yuji; Matsumoto, Takao; Ishikawa, Ryo; Ikuhara, Yuichi

2017-01-01

In scanning transmission electron microscopy (STEM), single atoms can be imaged by detecting electrons scattered through high angles using post-specimen, annular-type detectors. Recently, it has been shown that the atomic-scale electric field of both the positive atomic nuclei and the surrounding negative electrons within crystalline materials can be probed by atomic-resolution differential phase contrast STEM. Here we demonstrate the real-space imaging of the (projected) atomic electric field distribution inside single Au atoms, using sub-Å spatial resolution STEM combined with a high-speed segmented detector. We directly visualize that the electric field distribution (blurred by the sub-Å size electron probe) drastically changes within the single Au atom in a shape that relates to the spatial variation of total charge density within the atom. Atomic-resolution electric field mapping with single-atom sensitivity enables us to examine their detailed internal and boundary structures. PMID:28555629

Polarization resolved imaging with a reflection near-field optical microscope

DEFF Research Database (Denmark)

Bozhevolnyi, Sergey I.; Xiao, Mufei; Hvam, Jørn Märcher

1999-01-01

Using a rigorous microscopic point-dipole description of probe-sample interactions, we study imaging with a reflection scanning near-field optical microscope. Optical content, topographical artifacts, sensitivity window-i.e., the scale on which near-field optical images represent mainly optical...... configuration is preferable to the cross-linear one, since it ensures more isotropic (in the surface plane) near-field imaging of surface features. The numerical results are supported with experimental near-field images obtained by using a reflection microscope with an uncoated fiber tip....

Active optics and modified-Rumsey wide-field telescopes: MINITRUST demonstrators with vase- and tulip-form mirrors

Science.gov (United States)

Lemaître, Gérard R.; Montiel, Pierre; Joulié, Patrice; Dohlen, Kjetil; Lanzoni, Patrick

2005-12-01

Wide-field astronomy requires the development of larger aperture telescopes. The optical properties of a three-mirror modified-Rumsey design provide significant advantages when compared to other telescope designs: (i) at any wavelength, the design has a flat field and is anastigmatic; (ii) the system is extremely compact, i.e., it is almost four times shorter than a Schmidt. Compared to the equally compact flat-field Ritchey-Chrétien with a doublet-lens corrector, as developed for the Sloan digital sky survey - and which requires the polishing of six optical surfaces - the proposed modified-Rumsey design requires only a two-surface polishing and provides a better imaging quality. All the mirrors are spheroids of the hyperboloid type. Starting from the classical Rumsey design, it is shown that the use of all eight available free parameters allows the simultaneous aspherization of the primary and tertiary mirrors by active optics methods from a single deformable substrate. The continuity conditions between the primary and the tertiary hyperbolizations are achieved by an intermediate narrow ring of constant thickness that is not optically used. After the polishing of a double vase form in a spherical shape, the primary-tertiary hyperbolizations are achieved by in situ stressing. The tulip-form secondary is hyperbolized by stress polishing. Other active optics alternatives are possible for a space telescope. The modified-Rumsey design is of interest for developing large space- and ground-based survey telescopes in UV, visible, or IR ranges, such as currently demonstrated with the construction of identical telescopes MINITRUST-1 and -2, f/5 - 2° field of view. Double-pass optical tests show diffraction-limited images.

Active optics and the axisymmetric case: MINITRUST wide-field three-reflection telescopes with mirrors aspherized from tulip and vase forms

Science.gov (United States)

Lemaitre, Gerard R.; Montiel, Pierre; Joulie, Patrice; Dohlen, Kjetil; Lanzoni, Patrick

2004-09-01

Wide-field astronomy requires larger size telescopes. Compared to the catadioptric Schmidt, the optical properties of a three mirror telescope provides significant advantages. (1) The flat field design is anastigmatic at any wavelength, (2) the system is extremely compact -- four times shorter than a Schmidt -- and, (3) compared to a Schmidt with refractive corrector -- requiring the polishing of three optical surfaces --, the presently proposed Modified-Rumsey design uses all of eight available free parameters of a flat fielded anastigmatic three mirror telescope for mirrors generated by active optics methods. Compared to a Rumsey design, these parameters include the additional slope continuity condition at the primary-tertiary link for in-situ stressing and aspherization from a common sphere. Then, active optics allows the polishing of only two spherical surfaces: the combined primary-tertiary mirror and the secondary mirror. All mirrors are spheroids of the hyperboloid type. This compact system is of interest for space and ground-based astronomy and allows to built larger wide-field telescopes such as demonstrated by the design and construction of identical telescopes MINITRUST-1 and -2, f/5 - 2° FOV, consisting of an in-situ stressed double vase form primary-tertiary and of a stress polished tulip form secondary. Optical tests of these telescopes, showing diffraction limited images, are presented.

OP09O-OP404-9 Wide Field Camera 3 CCD Quantum Efficiency Hysteresis

Science.gov (United States)

Collins, Nick

2009-01-01

The HST/Wide Field Camera (WFC) 3 UV/visible channel CCD detectors have exhibited an unanticipated quantum efficiency hysteresis (QEH) behavior. At the nominal operating temperature of -83C, the QEH feature contrast was typically 0.1-0.2% or less. The behavior was replicated using flight spare detectors. A visible light flat-field (540nm) with a several times full-well signal level can pin the detectors at both optical (600nm) and near-UV (230nm) wavelengths, suppressing the QEH behavior. We are characterizing the timescale for the detectors to become unpinned and developing a protocol for flashing the WFC3 CCDs with the instrument's internal calibration system in flight. The HST/Wide Field Camera 3 UV/visible channel CCD detectors have exhibited an unanticipated quantum efficiency hysteresis (QEH) behavior. The first observed manifestation of QEH was the presence in a small percentage of flat-field images of a bowtie-shaped contrast that spanned the width of each chip. At the nominal operating temperature of -83C, the contrast observed for this feature was typically 0.1-0.2% or less, though at warmer temperatures contrasts up to 5% (at -50C) have been observed. The bowtie morphology was replicated using flight spare detectors in tests at the GSFC Detector Characterization Laboratory by power cycling the detector while cold. Continued investigation revealed that a clearly-related global QE suppression at the approximately 5% level can be produced by cooling the detector in the dark; subsequent flat-field exposures at a constant illumination show asymptotically increasing response. This QE "pinning" can be achieved with a single high signal flat-field or a series of lower signal flats; a visible light (500-580nm) flat-field with a signal level of several hundred thousand electrons per pixel is sufficient for QE pinning at both optical (600nm) and near-UV (230nm) wavelengths. We are characterizing the timescale for the detectors to become unpinned and developing a

Decompositions of bubbly flow PIV velocity fields using discrete wavelets multi-resolution and multi-section image method

International Nuclear Information System (INIS)

Choi, Je-Eun; Takei, Masahiro; Doh, Deog-Hee; Jo, Hyo-Jae; Hassan, Yassin A.; Ortiz-Villafuerte, Javier

2008-01-01

Currently, wavelet transforms are widely used for the analyses of particle image velocimetry (PIV) velocity vector fields. This is because the wavelet provides not only spatial information of the velocity vectors, but also of the time and frequency domains. In this study, a discrete wavelet transform is applied to real PIV images of bubbly flows. The vector fields obtained by a self-made cross-correlation PIV algorithm were used for the discrete wavelet transform. The performances of the discrete wavelet transforms were investigated by changing the level of power of discretization. The images decomposed by wavelet multi-resolution showed conspicuous characteristics of the bubbly flows for the different levels. A high spatial bubble concentrated area could be evaluated by the constructed discrete wavelet transform algorithm, in which high-leveled wavelets play dominant roles in revealing the flow characteristics

Short-channel field-effect transistors with 9-atom and 13-atom wide graphene nanoribbons.

Science.gov (United States)

Llinas, Juan Pablo; Fairbrother, Andrew; Borin Barin, Gabriela; Shi, Wu; Lee, Kyunghoon; Wu, Shuang; Yong Choi, Byung; Braganza, Rohit; Lear, Jordan; Kau, Nicholas; Choi, Wonwoo; Chen, Chen; Pedramrazi, Zahra; Dumslaff, Tim; Narita, Akimitsu; Feng, Xinliang; Müllen, Klaus; Fischer, Felix; Zettl, Alex; Ruffieux, Pascal; Yablonovitch, Eli; Crommie, Michael; Fasel, Roman; Bokor, Jeffrey

2017-09-21

Bottom-up synthesized graphene nanoribbons and graphene nanoribbon heterostructures have promising electronic properties for high-performance field-effect transistors and ultra-low power devices such as tunneling field-effect transistors. However, the short length and wide band gap of these graphene nanoribbons have prevented the fabrication of devices with the desired performance and switching behavior. Here, by fabricating short channel (L ch  ~ 20 nm) devices with a thin, high-κ gate dielectric and a 9-atom wide (0.95 nm) armchair graphene nanoribbon as the channel material, we demonstrate field-effect transistors with high on-current (I on  > 1 μA at V d  = -1 V) and high I on /I off  ~ 10 5 at room temperature. We find that the performance of these devices is limited by tunneling through the Schottky barrier at the contacts and we observe an increase in the transparency of the barrier by increasing the gate field near the contacts. Our results thus demonstrate successful fabrication of high-performance short-channel field-effect transistors with bottom-up synthesized armchair graphene nanoribbons.Graphene nanoribbons show promise for high-performance field-effect transistors, however they often suffer from short lengths and wide band gaps. Here, the authors use a bottom-up synthesis approach to fabricate 9- and 13-atom wide ribbons, enabling short-channel transistors with 10 5 on-off current ratio.

ASTC-MIMO-TOPS Mode with Digital Beam-Forming in Elevation for High-Resolution Wide-Swath Imaging

Directory of Open Access Journals (Sweden)

Pingping Huang

2015-03-01

Full Text Available Future spaceborne synthetic aperture radar (SAR missions require complete and frequent coverage of the earth with a high resolution. Terrain Observation by Progressive Scans (TOPS is a novel wide swath mode but has impaired azimuth resolution. In this paper, an innovative extended TOPS mode named Alamouti Space-time Coding multiple-input multiple-output TOPS (ASTC-MIMO-TOPS mode combined with digital beam-forming (DBF in elevation and multi-aperture SAR signal reconstruction in azimuth is proposed. This innovative mode achieves wide-swath coverage with a high geometric resolution and also overcomes major drawbacks in conventional MIMO SAR systems. The data processing scheme of this imaging scheme is presented in detail. The designed system example of the proposed ASTC-MIMO-TOPS mode, which has the imaging capacity of a 400 km wide swath with an azimuth resolution of 3 m, is given. Its system performance analysis results and simulated imaging results on point targets demonstrate the potential of the proposed novel spaceborne SAR mode for high-resolution wide-swath (HRWS imaging.

A Comprehensive Study of ULIRGs in the Herschel Very Wide Field Surveys

Science.gov (United States)

Yan, Haojing

Extreme starbursting galaxies exist at all redshifts, and most of them are so heavily obscured by dust that they are Ultra-Luminous InfraRed Galaxies (ULIRGs) while being faint in optical to near-IR. The latest example is at record-high z=6.337, approaching the end of the reionization. There have been numerous suggestions that understanding ULIRG is critical in constructing a comprehensive picture of galaxy formation history. These range from the hypothesis three decades ago that the ULIRG phase is the prelude to QSO and large ellipticals, to the recent tentative evidence that ULIRG could make a large (if not dominant) contribution to the global star formation rate density (GSFRD) at z>1. However, the exact nature of ULIRG and their role in galaxy assembly still remain illusive, largely due to the limited sample size and the severe source confusion problem in the far-IR (FIR). The very wide field surveys by Herschel have provided the best opportunity to date to systematically study ULIRG beyond the local universe, most importantly because of their wide coverage and high sensitivity to probe large volumes to high redshifts and the multiple FIR bands that allow for direct measurement of the IR luminosities. We propose to construct the largest possible ULIRG sample in these fields at all redshifts, and to study the evolution of ULIRGs. We will concentrate on the HerMES, the H-ATLAS and the HerS programs whose data are already public. While the confusion problem still persists in these Herschel data, we have demonstrated that it is possible to directly use the position priors from optical images to decompose the candidate contributors to a given Herschel source if its S/N suffices (Yan et al. 2014). This is a significant improvement over previous studies where higher-resolution mid-IR (mostly Spitzer MIPS 24-micron) data had to be used as the proxies to the FIR source locations, because (1) such proxy images also suffer from the blending problem in the first place and

Imaging at ultrahigh magnetic fields: History, challenges, and solutions.

Science.gov (United States)

Uğurbil, Kamil

2018-03-01

Following early efforts in applying nuclear magnetic resonance (NMR) spectroscopy to study biological processes in intact systems, and particularly since the introduction of 4 T human scanners circa 1990, rapid progress was made in imaging and spectroscopy studies of humans at 4 T and animal models at 9.4 T, leading to the introduction of 7 T and higher magnetic fields for human investigation at about the turn of the century. Work conducted on these platforms has provided numerous technological solutions to challenges posed at these ultrahigh fields, and demonstrated the existence of significant advantages in signal-to-noise ratio and biological information content. Primary difference from lower fields is the deviation from the near field regime at the radiofrequencies (RF) corresponding to hydrogen resonance conditions. At such ultrahigh fields, the RF is characterized by attenuated traveling waves in the human body, which leads to image non-uniformities for a given sample-coil configuration because of destructive and constructive interferences. These non-uniformities were initially considered detrimental to progress of imaging at high field strengths. However, they are advantageous for parallel imaging in signal reception and transmission, two critical technologies that account, to a large extend, for the success of ultrahigh fields. With these technologies and improvements in instrumentation and imaging methods, today ultrahigh fields have provided unprecedented gains in imaging of brain function and anatomy, and started to make inroads into investigation of the human torso and extremities. As extensive as they are, these gains still constitute a prelude to what is to come given the increasingly larger effort committed to ultrahigh field research and development of ever better instrumentation and techniques. Copyright © 2017 Elsevier Inc. All rights reserved.

Field application of feature-enhanced imaging

International Nuclear Information System (INIS)

Mucciardi, A.N.

1988-01-01

One of the more challenging ultrasonic inspection problems is bimetallic weld inspection or, in general, dissimilar metal welds. These types of welds involve complicated geometries and various mixtures of materials. Attempts to address this problem with imaging alone have fallen short of desired goals. The probable reason for this is the lack of information supplied by imaging systems, which are limited to amplitude and time displays. Having RF information available for analysis greatly enhances the information obtainable from dissimilar metal welds and, coupled with the spatial map generated by an imaging system, can significantly improve the reliability of dissimilar metal weld inspections. Ultra Image and TestPro are, respectively, an imaging system and a feature-based signal analysis system. The purpose of this project is to integrate these two systems to produce a feature-enhanced imaging system. This means that a software link is established between Ultra Image and the PC-based TestPro system so that the user of the combined system can perform all the usual imaging functions and also have available a wide variety of RF signal analysis functions. The analysis functions include waveform feature-based pattern recognition as well as artificial intelligence/expert system techniques

A spectral k-means approach to bright-field cell image segmentation.

Science.gov (United States)

Bradbury, Laura; Wan, Justin W L

2010-01-01

Automatic segmentation of bright-field cell images is important to cell biologists, but difficult to complete due to the complex nature of the cells in bright-field images (poor contrast, broken halo, missing boundaries). Standard approaches such as level set segmentation and active contours work well for fluorescent images where cells appear as round shape, but become less effective when optical artifacts such as halo exist in bright-field images. In this paper, we present a robust segmentation method which combines the spectral and k-means clustering techniques to locate cells in bright-field images. This approach models an image as a matrix graph and segment different regions of the image by computing the appropriate eigenvectors of the matrix graph and using the k-means algorithm. We illustrate the effectiveness of the method by segmentation results of C2C12 (muscle) cells in bright-field images.

Quantitative Image Restoration in Bright Field Optical Microscopy.

Science.gov (United States)

Gutiérrez-Medina, Braulio; Sánchez Miranda, Manuel de Jesús

2017-11-07

Bright field (BF) optical microscopy is regarded as a poor method to observe unstained biological samples due to intrinsic low image contrast. We introduce quantitative image restoration in bright field (QRBF), a digital image processing method that restores out-of-focus BF images of unstained cells. Our procedure is based on deconvolution, using a point spread function modeled from theory. By comparing with reference images of bacteria observed in fluorescence, we show that QRBF faithfully recovers shape and enables quantify size of individual cells, even from a single input image. We applied QRBF in a high-throughput image cytometer to assess shape changes in Escherichia coli during hyperosmotic shock, finding size heterogeneity. We demonstrate that QRBF is also applicable to eukaryotic cells (yeast). Altogether, digital restoration emerges as a straightforward alternative to methods designed to generate contrast in BF imaging for quantitative analysis. Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved.

SHOK—The First Russian Wide-Field Optical Camera in Space

Science.gov (United States)

Lipunov, V. M.; Gorbovskoy, E. S.; Kornilov, V. G.; Panasyuk, M. I.; Amelushkin, A. M.; Petrov, V. L.; Yashin, I. V.; Svertilov, S. I.; Vedenkin, N. N.

2018-02-01

Onboard the spacecraft Lomonosov is established two fast, fixed, very wide-field cameras SHOK. The main goal of this experiment is the observation of GRB optical emission before, synchronously, and after the gamma-ray emission. The field of view of each of the cameras is placed in the gamma-ray burst detection area of other devices located onboard the "Lomonosov" spacecraft. SHOK provides measurements of optical emissions with a magnitude limit of ˜ 9-10m on a single frame with an exposure of 0.2 seconds. The device is designed for continuous sky monitoring at optical wavelengths in the very wide field of view (1000 square degrees each camera), detection and localization of fast time-varying (transient) optical sources on the celestial sphere, including provisional and synchronous time recording of optical emissions from the gamma-ray burst error boxes, detected by the BDRG device and implemented by a control signal (alert trigger) from the BDRG. The Lomonosov spacecraft has two identical devices, SHOK1 and SHOK2. The core of each SHOK device is a fast-speed 11-Megapixel CCD. Each of the SHOK devices represents a monoblock, consisting of a node observations of optical emission, the electronics node, elements of the mechanical construction, and the body.

Improvement of Sidestream Dark Field Imaging with an Image Acquisition Stabilizer

NARCIS (Netherlands)

Balestra, Gianmarco M.; Bezemer, Rick; Boerma, E. Christiaan; Yong, Ze-Yie; Sjauw, Krishan D.; Engstrom, Annemarie E.; Koopmans, Matty; Ince, Can

2010-01-01

ABSTRACT: BACKGROUND: In the present study we developed, evaluated in volunteers, and clinically validated an image acquisition stabilizer (IAS) for Sidestream Dark Field (SDF) imaging. METHODS: The IAS is a stainless steel sterilizable ring which fits around the SDF probe tip. The IAS creates

Improvement of Sidestream Dark Field Imaging with an Image Acquisition Stabilizer

NARCIS (Netherlands)

G. Balestra (Gianmarco); R. Bezemer (Rick); E.C. Boerma (Christiaan); Z-Y. Yong (Ze-Yie); K.D. Sjauw (Krishan); A.E. Engstrom (Annemarie); M. Koopmans (Matty); C. Ince (Can)

2010-01-01

textabstractBackground: In the present study we developed, evaluated in volunteers, and clinically validated an image acquisition stabilizer (IAS) for Sidestream Dark Field (SDF) imaging.Methods: The IAS is a stainless steel sterilizable ring which fits around the SDF probe tip. The IAS creates

High-throughput dual-color precision imaging for brain-wide mapping of the connectome with cytoarchitectonic landmarks at the cellular level (Conference Presentation)

Science.gov (United States)

Luo, Qingming; Gong, Hui; Yuan, Jing; Li, Xiangning; Li, Anan; Xu, Tonghui

2017-02-01

Deciphering the fine morphology and precise location of neurons and neural circuits are crucial to enhance our understanding of brain function and diseases. Traditionally, we have to map brain images to coarse axial-sampling planar reference atlases to orient neural structures. However, this means might fail to orient neural projections at single-cell resolution due to position errors resulting from individual differences at the cellular level. Here, we present a high-throughput imaging method that can automatically obtain the fine morphologies and precise locations of both neurons and circuits, employing wide-field large-volume tomography to acquire three-dimensional images of thick tissue and implementing real-time soma counterstaining to obtain cytoarchitectonic landmarks during the imaging process. The reconstruction and orientation of brain-wide neural circuits at single-neuron resolution can be accomplished for the same mouse brain without additional counterstains or image registration. Using our method, mouse brain imaging datasets of multiple type-specific neurons and circuits were successfully acquired, demonstrating the versatility. The results show that the simultaneous acquisition of labeled neural structures and cytoarchitecture reference at single-neuron resolution in the same brain greatly facilitates precise tracing of long-range projections and accurate locating of nuclei. Our method provides a novel and effective tool for application in studies on genetic dissection, brain function and the pathology of the nervous system.

Stereoscopic Integrated Imaging Goggles for Multimodal Intraoperative Image Guidance.

Directory of Open Access Journals (Sweden)

Christopher A Mela

Full Text Available We have developed novel stereoscopic wearable multimodal intraoperative imaging and display systems entitled Integrated Imaging Goggles for guiding surgeries. The prototype systems offer real time stereoscopic fluorescence imaging and color reflectance imaging capacity, along with in vivo handheld microscopy and ultrasound imaging. With the Integrated Imaging Goggle, both wide-field fluorescence imaging and in vivo microscopy are provided. The real time ultrasound images can also be presented in the goggle display. Furthermore, real time goggle-to-goggle stereoscopic video sharing is demonstrated, which can greatly facilitate telemedicine. In this paper, the prototype systems are described, characterized and tested in surgeries in biological tissues ex vivo. We have found that the system can detect fluorescent targets with as low as 60 nM indocyanine green and can resolve structures down to 0.25 mm with large FOV stereoscopic imaging. The system has successfully guided simulated cancer surgeries in chicken. The Integrated Imaging Goggle is novel in 4 aspects: it is (a the first wearable stereoscopic wide-field intraoperative fluorescence imaging and display system, (b the first wearable system offering both large FOV and microscopic imaging simultaneously,

Radar Images of the Earth and the World Wide Web

Science.gov (United States)

Chapman, B.; Freeman, A.

1995-01-01

A perspective of NASA's Jet Propulsion Laboratory as a center of planetary exploration, and its involvement in studying the earth from space is given. Remote sensing, radar maps, land topography, snow cover properties, vegetation type, biomass content, moisture levels, and ocean data are items discussed related to earth orbiting satellite imaging radar. World Wide Web viewing of this content is discussed.

Wide-band acousto-optic deflectors for large field of view two-photon microscope.

Science.gov (United States)

Jiang, Runhua; Zhou, Zhenqiao; Lv, Xiaohua; Zeng, Shaoqun

2012-04-01

Acousto-optic deflector (AOD) is an attractive scanner for two-photon microscopy because it can provide fast and versatile laser scanning and does not involve any mechanical movements. However, due to the small scan range of available AOD, the field of view (FOV) of the AOD-based microscope is typically smaller than that of the conventional galvanometer-based microscope. Here, we developed a novel wide-band AOD to enlarge the scan angle. Considering the maximum acceptable acoustic attenuation in the acousto-optic crystal, relatively lower operating frequencies and moderate aperture were adopted. The custom AOD was able to provide 60 MHz 3-dB bandwidth and 80% peak diffraction efficiency at 840 nm wavelength. Based on a pair of such AOD, a large FOV two-photon microscope was built with a FOV up to 418.5 μm (40× objective). The spatiotemporal dispersion was compensated simultaneously with a single custom-made prism. By means of dynamic power modulation, the variation of laser intensity within the FOV was reduced below 5%. The lateral and axial resolution of the system were 0.58-2.12 μm and 2.17-3.07 μm, respectively. Pollen grain images acquired by this system were presented to demonstrate the imaging capability at different positions across the entire FOV. © 2012 American Institute of Physics

Handheld and mobile hyperspectral imaging sensors for wide-area standoff detection of explosives and chemical warfare agents

Science.gov (United States)

Gomer, Nathaniel R.; Gardner, Charles W.; Nelson, Matthew P.

2016-05-01

Hyperspectral imaging (HSI) is a valuable tool for the investigation and analysis of targets in complex background with a high degree of autonomy. HSI is beneficial for the detection of threat materials on environmental surfaces, where the concentration of the target of interest is often very low and is typically found within complex scenery. Two HSI techniques that have proven to be valuable are Raman and shortwave infrared (SWIR) HSI. Unfortunately, current generation HSI systems have numerous size, weight, and power (SWaP) limitations that make their potential integration onto a handheld or field portable platform difficult. The systems that are field-portable do so by sacrificing system performance, typically by providing an inefficient area search rate, requiring close proximity to the target for screening, and/or eliminating the potential to conduct real-time measurements. To address these shortcomings, ChemImage Sensor Systems (CISS) is developing a variety of wide-field hyperspectral imaging systems. Raman HSI sensors are being developed to overcome two obstacles present in standard Raman detection systems: slow area search rate (due to small laser spot sizes) and lack of eye-safety. SWIR HSI sensors have been integrated into mobile, robot based platforms and handheld variants for the detection of explosives and chemical warfare agents (CWAs). In addition, the fusion of these two technologies into a single system has shown the feasibility of using both techniques concurrently to provide higher probability of detection and lower false alarm rates. This paper will provide background on Raman and SWIR HSI, discuss the applications for these techniques, and provide an overview of novel CISS HSI sensors focused on sensor design and detection results.

On the pinned field image binarization for signature generation in image ownership verification method

Directory of Open Access Journals (Sweden)

Chang Hsuan

2011-01-01

Full Text Available Abstract The issue of pinned field image binarization for signature generation in the ownership verification of the protected image is investigated. The pinned field explores the texture information of the protected image and can be employed to enhance the watermark robustness. In the proposed method, four optimization schemes are utilized to determine the threshold values for transforming the pinned field into a binary feature image, which is then utilized to generate an effective signature image. Experimental results show that the utilization of optimization schemes can significantly improve the signature robustness from the previous method (Lee and Chang, Opt. Eng. 49 (9, 097005, 2010. While considering both the watermark retrieval rate and the computation speed, the genetic algorithm is strongly recommended. In addition, compared with Chang and Lin's scheme (J. Syst. Softw. 81 (7, 1118-1129, 2008, the proposed scheme also has better performance.

Wide area 2D/3D imaging development, analysis and applications

CERN Document Server

Langmann, Benjamin

2014-01-01

Imaging technology is an important research area and it is widely utilized in a growing number of disciplines ranging from gaming, robotics and automation to medicine. In the last decade 3D imaging became popular mainly driven by the introduction of novel 3D cameras and measuring devices. These cameras are usually limited to indoor scenes with relatively low distances. Benjamin Langmann introduces medium and long-range 2D/3D cameras to overcome these limitations. He reports measurement results for these devices and studies their characteristic behavior. In order to facilitate the application o

Electric field effects in scanning tunneling microscope imaging

DEFF Research Database (Denmark)

Stokbro, Kurt; Quaade, Ulrich; Grey, Francois

1998-01-01

We present a high-voltage extension of the Tersoff-Hamann theory of scanning tunneling microscope (STM) images, which includes the effect of the electric field between the tip and the sample. The theoretical model is based on first-principles electronic structure calculations and has no adjustable...... parameters. We use the method to calculate theoretical STM images of the monohydrate Si(100)-H(2x1) surface with missing hydrogen defects at -2V and find an enhanced corrugation due to the electric field, in good agreement with experimental images....

Plenoptic Imaging for Three-Dimensional Particle Field Diagnostics.

Energy Technology Data Exchange (ETDEWEB)

Guildenbecher, Daniel Robert [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hall, Elise Munz [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-06-01

Plenoptic imaging is a promising emerging technology for single-camera, 3D diagnostics of particle fields. In this work, recent developments towards quantitative measurements of particle size, positions, and velocities are discussed. First, the technique is proven viable with measurements of the particle field generated by the impact of a water drop on a thin film of water. Next, well cont rolled experiments are used to verify diagnostic uncertainty. Finally, an example is presented of 3D plenoptic imaging of a laboratory scale, explosively generated fragment field.

Alaskan Auroral All-Sky Images on the World Wide Web

Science.gov (United States)

Stenbaek-Nielsen, H. C.

1997-01-01

In response to a 1995 NASA SPDS announcement of support for preservation and distribution of important data sets online, the Geophysical Institute, University of Alaska Fairbanks, Alaska, proposed to provide World Wide Web access to the Poker Flat Auroral All-sky Camera images in real time. The Poker auroral all-sky camera is located in the Davis Science Operation Center at Poker Flat Rocket Range about 30 miles north-east of Fairbanks, Alaska, and is connected, through a microwave link, with the Geophysical Institute where we maintain the data base linked to the Web. To protect the low light-level all-sky TV camera from damage due to excessive light, we only operate during the winter season when the moon is down. The camera and data acquisition is now fully computer controlled. Digital images are transmitted each minute to the Web linked data base where the data are available in a number of different presentations: (1) Individual JPEG compressed images (1 minute resolution); (2) Time lapse MPEG movie of the stored images; and (3) A meridional plot of the entire night activity.

Full-field x-ray nano-imaging at SSRF

Science.gov (United States)

Deng, Biao; Ren, Yuqi; Wang, Yudan; Du, Guohao; Xie, Honglan; Xiao, Tiqiao

2013-09-01

Full field X-ray nano-imaging focusing on material science is under developing at SSRF. A dedicated full field X-ray nano-imaging beamline based on bending magnet will be built in the SSRF phase-II project. The beamline aims at the 3D imaging of the nano-scale inner structures. The photon energy range is of 5-14keV. The design goals with the field of view (FOV) of 20μm and a spatial resolution of 20nm are proposed at 8 keV, taking a Fresnel zone plate (FZP) with outermost zone width of 25 nm. Futhermore, an X-ray nano-imaging microscope is under developing at the SSRF BL13W beamline, in which a larger FOV will be emphasized. This microscope is based on a beam shaper and a zone plate using both absorption contrast and Zernike phase contrast, with the optimized energy set to 10keV. The detailed design and the progress of the project will be introduced.

Near-field millimeter - wave imaging of nonmetallic materials

International Nuclear Information System (INIS)

Gopalsami, N.; Bakhtiari, S.; Raptis, A.C.

1996-01-01

A near-field millimeter-wave (mm-wave) imaging system has been designed and built in the 94-GHz range for on-line inspection of nonmetallic (dielectric) materials. The imaging system consists of a transceiver block coupled to an antenna that scans the material to be imaged; a reflector plate is placed behind the material. A quadrature IF mixer in the transceiver block enables measurement of in-phase and quadrature-phase components of reflected signals with respect to the transmitted signal. All transceiver components, with the exception of the Gunn-diode oscillator and antenna, were fabricated in uniform blocks and integrated and packaged into a compact unit (12.7 x 10.2 x 2.5 cm). The objective of this work is to test the applicability of a near-field compact mm-wave sensor for on-line inspection of sheetlike materials such as paper, fabrics, and plastics. This paper presents initial near-field mm-wave images of paper and fabric samples containing known artifacts

Image-guided regularization level set evolution for MR image segmentation and bias field correction.

Science.gov (United States)

Wang, Lingfeng; Pan, Chunhong

2014-01-01

Magnetic resonance (MR) image segmentation is a crucial step in surgical and treatment planning. In this paper, we propose a level-set-based segmentation method for MR images with intensity inhomogeneous problem. To tackle the initialization sensitivity problem, we propose a new image-guided regularization to restrict the level set function. The maximum a posteriori inference is adopted to unify segmentation and bias field correction within a single framework. Under this framework, both the contour prior and the bias field prior are fully used. As a result, the image intensity inhomogeneity can be well solved. Extensive experiments are provided to evaluate the proposed method, showing significant improvements in both segmentation and bias field correction accuracies as compared with other state-of-the-art approaches. Copyright © 2014 Elsevier Inc. All rights reserved.

Improvement of Sidestream Dark Field Imaging with an Image Acquisition Stabilizer

OpenAIRE

Balestra, Gianmarco M; Bezemer, Rick; Boerma, E Christiaan; Yong, Ze-Yie; Sjauw, Krishan D; Engstrom, Annemarie E; Koopmans, Matty; Ince, Can

2010-01-01

Abstract Background In the present study we developed, evaluated in volunteers, and clinically validated an image acquisition stabilizer (IAS) for Sidestream Dark Field (SDF) imaging. Methods The IAS is a stainless steel sterilizable ring which fits around the SDF probe tip. The IAS creates adhesion to the imaged tissue by application of negative pressure. The effects of the IAS on the sublingual microcirculatory flow velocities, the force required to induce pressure artifacts (PA), the time ...

Deployment of the Hobby-Eberly Telescope wide-field upgrade

Science.gov (United States)

Hill, Gary J.; Drory, Niv; Good, John M.; Lee, Hanshin; Vattiat, Brian L.; Kriel, Herman; Ramsey, Jason; Bryant, Randy; Elliot, Linda; Fowler, Jim; Häuser, Marco; Landiau, Martin; Leck, Ron; Odewahn, Stephen; Perry, Dave; Savage, Richard; Schroeder Mrozinski, Emily; Shetrone, Matthew; DePoy, D. L.; Prochaska, Travis; Marshall, J. L.; Damm, George; Gebhardt, Karl; MacQueen, Phillip J.; Martin, Jerry; Armandroff, Taft; Ramsey, Lawrence W.

2016-07-01

The Hobby-Eberly Telescope (HET) is an innovative large telescope, located in West Texas at the McDonald Observatory. The HET operates with a fixed segmented primary and has a tracker, which moves the four-mirror corrector and prime focus instrument package to track the sidereal and non-sidereal motions of objects. We have completed a major multi-year upgrade of the HET that has substantially increased the pupil size to 10 meters and the field of view to 22 arcminutes by replacing the corrector, tracker, and prime focus instrument package. The new wide field HET will feed the revolutionary integral field spectrograph called VIRUS, in support of the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX§), a new low resolution spectrograph (LRS2), an upgraded high resolution spectrograph (HRS2), and later the Habitable Zone Planet Finder (HPF). The upgrade is being commissioned and this paper discusses the completion of the installation, the commissioning process and the performance of the new HET.

THz near-field imaging of biological tissues employing synchrotronradiation

Energy Technology Data Exchange (ETDEWEB)

Schade, Ulrich; Holldack, Karsten; Martin, Michael C.; Fried,Daniel

2004-12-23

Terahertz scanning near-field infrared microscopy (SNIM) below 1 THz is demonstrated. The near-field technique benefits from the broadband and highly brilliant coherent synchrotron radiation (CSR) from an electron storage ring and from a detection method based on locking onto the intrinsic time structure of the synchrotron radiation. The scanning microscope utilizes conical wave guides as near-field probes with apertures smaller than the wavelength. Different cone approaches have been investigated to obtain maximum transmittance. Together with a Martin-Puplett spectrometer the set-up enables spectroscopic mapping of the transmittance of samples well below the diffraction limit. Spatial resolution down to about lambda/40 at 2 wavenumbers (0.06 THz) is derived from the transmittance spectra of the near-field probes. The potential of the technique is exemplified by imaging biological samples. Strongly absorbing living leaves have been imaged in transmittance with a spatial resolution of 130 mu-m at about 12 wave numbers (0.36 THz). The THz near-field images reveal distinct structural differences of leaves from different plants investigated. The technique presented also allows spectral imaging of bulky organic tissues. Human teeth samples of various thicknesses have been imaged between 2 and 20 wavenumbers (between 0.06and 0.6 THz). Regions of enamel and dentin within tooth samples are spatially and spectrally resolved, and buried caries lesions are imaged through both the outer enamel and into the underlying dentin.

Relations of image quality in on-line portal images and individual patient parameters for pelvic field radiotherapy

International Nuclear Information System (INIS)

Heuvel, F. van den; Neve, W. de; Coghe, M.; Verellen, D.; Storme, G.

1992-01-01

The aims of the present study involving 566 pelvic fields on 13 patients were: 1. To study the machine- and patient-related factors influencing image quality. 2. To study the factors related to machine, patient and patient set-up, influencing the errors of field set-up. 3. To develop a method for predicting the camera settings. The OPI device consisted of a fluorescent screen scanned by a video camera. An image quality score on a scale 0-5 was given for 546/566 fields. In a univariate analysis, open field subtraction adversely affected the score. The image score of anterior fields was significantly better than that of posterior fields. Multivariate stepwise logistic regression showed that, in addition to anterior or posterior field and subtraction, gender was also a significant predictor of image score. Errors requiring field adjustments were detected on 289/530 (54.5%) evaluable fields or 229/278 (82.4%) evaluable patient set-ups. Multivariate logistic regression showed that the probability of performing an adjustment was significantly related to gender, image quality and AP-PA diameter. The magnitude of adjustments made in the lateral direction correlated significantly with patient bulk. The camera kV level with gain held constant showed an exponential dependency on dose rate at the image detector plate and can thus be predicted by treatment planning. (orig.)

Improvement of Sidestream Dark Field Imaging with an Image Acquisition Stabilizer

Directory of Open Access Journals (Sweden)

Sjauw Krishan D

2010-07-01

Full Text Available Abstract Background In the present study we developed, evaluated in volunteers, and clinically validated an image acquisition stabilizer (IAS for Sidestream Dark Field (SDF imaging. Methods The IAS is a stainless steel sterilizable ring which fits around the SDF probe tip. The IAS creates adhesion to the imaged tissue by application of negative pressure. The effects of the IAS on the sublingual microcirculatory flow velocities, the force required to induce pressure artifacts (PA, the time to acquire a stable image, and the duration of stable imaging were assessed in healthy volunteers. To demonstrate the clinical applicability of the SDF setup in combination with the IAS, simultaneous bilateral sublingual imaging of the microcirculation were performed during a lung recruitment maneuver (LRM in mechanically ventilated critically ill patients. One SDF device was operated handheld; the second was fitted with the IAS and held in position by a mechanic arm. Lateral drift, number of losses of image stability and duration of stable imaging of the two methods were compared. Results Five healthy volunteers were studied. The IAS did not affect microcirculatory flow velocities. A significantly greater force had to applied onto the tissue to induced PA with compared to without IAS (0.25 ± 0.15 N without vs. 0.62 ± 0.05 N with the IAS, p Conclusions The present study has validated the use of an IAS for improvement of SDF imaging by demonstrating that the IAS did not affect microcirculatory perfusion in the microscopic field of view. The IAS improved both axial and lateral SDF image stability and thereby increased the critical force required to induce pressure artifacts. The IAS ensured a significantly increased duration of maintaining a stable image sequence.

Development of stable monolithic wide-field Michelson interferometers.

Science.gov (United States)

Wan, Xiaoke; Ge, Jian; Chen, Zhiping

2011-07-20

Bulk wide-field Michelson interferometers are very useful for high precision applications in remote sensing and astronomy. A stable monolithic Michelson interferometer is a key element in high precision radial velocity (RV) measurements for extrasolar planets searching and studies. Thermal stress analysis shows that matching coefficients of thermal expansion (CTEs) is a critical requirement for ensuring interferometer stability. This requirement leads to a novel design using BK7 and LAK7 materials, such that the monolithic interferometer is free from thermal distortion. The processes of design, fabrication, and testing of interferometers are described in detail. In performance evaluations, the field angle is typically 23.8° and thermal sensitivity is typically -2.6×10(-6)/°C near 550 nm, which corresponds to ∼800 m/s/°C in the RV scale. Low-cost interferometer products have been commissioned in multiple RV instruments, and they are producing high stability performance over long term operations. © 2011 Optical Society of America

Accuracy of ultra-wide-field fundus ophthalmoscopy-assisted deep learning, a machine-learning technology, for detecting age-related macular degeneration.

Science.gov (United States)

Matsuba, Shinji; Tabuchi, Hitoshi; Ohsugi, Hideharu; Enno, Hiroki; Ishitobi, Naofumi; Masumoto, Hiroki; Kiuchi, Yoshiaki

2018-05-09

To predict exudative age-related macular degeneration (AMD), we combined a deep convolutional neural network (DCNN), a machine-learning algorithm, with Optos, an ultra-wide-field fundus imaging system. First, to evaluate the diagnostic accuracy of DCNN, 364 photographic images (AMD: 137) were amplified and the area under the curve (AUC), sensitivity and specificity were examined. Furthermore, in order to compare the diagnostic abilities between DCNN and six ophthalmologists, we prepared yield 84 sheets comprising 50% of normal and wet-AMD data each, and calculated the correct answer rate, specificity, sensitivity, and response times. DCNN exhibited 100% sensitivity and 97.31% specificity for wet-AMD images, with an average AUC of 99.76%. Moreover, comparing the diagnostic abilities of DCNN versus six ophthalmologists, the average accuracy of the DCNN was 100%. On the other hand, the accuracy of ophthalmologists, determined only by Optos images without a fundus examination, was 81.9%. A combination of DCNN with Optos images is not better than a medical examination; however, it can identify exudative AMD with a high level of accuracy. Our system is considered useful for screening and telemedicine.

Agreement between image grading of conventional (45°) and ultra wide-angle (200°) digital images in the macula in the Reykjavik eye study.

Science.gov (United States)

Csutak, A; Lengyel, I; Jonasson, F; Leung, I; Geirsdottir, A; Xing, W; Peto, T

2010-10-01

To establish the agreement between image grading of conventional (45°) and ultra wide-angle (200°) digital images in the macula. In 2008, the 12-year follow-up was conducted on 573 participants of the Reykjavik Eye Study. This study included the use of the Optos P200C AF ultra wide-angle laser scanning ophthalmoscope alongside Zeiss FF 450 conventional digital fundus camera on 121 eyes with or without age-related macular degeneration using the International Classification System. Of these eyes, detailed grading was carried out on five cases each with hard drusen, geographic atrophy and chorioretinal neovascularisation, and six cases of soft drusen. Exact agreement and κ-statistics were calculated. Comparison of the conventional and ultra wide-angle images in the macula showed an overall 96.43% agreement (κ=0.93) with no disagreement at end-stage disease; although in one eye chorioretinal neovascularisation was graded as drusenoid pigment epithelial detachment. Of patients with drusen only, the exact agreement was 96.1%. The detailed grading showed no clinically significant disagreement between the conventional 45° and 200° images. On the basis of our results, there is a good agreement between grading conventional and ultra wide-angle images in the macula.

Improvement of sidestream dark field imaging with an image acquisition stabilizer.

Science.gov (United States)

Balestra, Gianmarco M; Bezemer, Rick; Boerma, E Christiaan; Yong, Ze-Yie; Sjauw, Krishan D; Engstrom, Annemarie E; Koopmans, Matty; Ince, Can

2010-07-13

In the present study we developed, evaluated in volunteers, and clinically validated an image acquisition stabilizer (IAS) for Sidestream Dark Field (SDF) imaging. The IAS is a stainless steel sterilizable ring which fits around the SDF probe tip. The IAS creates adhesion to the imaged tissue by application of negative pressure. The effects of the IAS on the sublingual microcirculatory flow velocities, the force required to induce pressure artifacts (PA), the time to acquire a stable image, and the duration of stable imaging were assessed in healthy volunteers. To demonstrate the clinical applicability of the SDF setup in combination with the IAS, simultaneous bilateral sublingual imaging of the microcirculation were performed during a lung recruitment maneuver (LRM) in mechanically ventilated critically ill patients. One SDF device was operated handheld; the second was fitted with the IAS and held in position by a mechanic arm. Lateral drift, number of losses of image stability and duration of stable imaging of the two methods were compared. Five healthy volunteers were studied. The IAS did not affect microcirculatory flow velocities. A significantly greater force had to applied onto the tissue to induced PA with compared to without IAS (0.25 +/- 0.15 N without vs. 0.62 +/- 0.05 N with the IAS, p IAS ensured an increased duration of a stable image sequence (8 +/- 2 s without vs. 42 +/- 8 s with the IAS, p IAS. In eight mechanically ventilated patients undergoing a LRM the use of the IAS resulted in a significantly reduced image drifting and enabled the acquisition of significantly longer stable image sequences (24 +/- 5 s without vs. 67 +/- 14 s with the IAS, p = 0.006). The present study has validated the use of an IAS for improvement of SDF imaging by demonstrating that the IAS did not affect microcirculatory perfusion in the microscopic field of view. The IAS improved both axial and lateral SDF image stability and thereby increased the critical force required

Numerical modeling of Harmonic Imaging and Pulse Inversion fields

Science.gov (United States)

Humphrey, Victor F.; Duncan, Tracy M.; Duck, Francis

2003-10-01

Tissue Harmonic Imaging (THI) and Pulse Inversion (PI) Harmonic Imaging exploit the harmonics generated as a result of nonlinear propagation through tissue to improve the performance of imaging systems. A 3D finite difference model, that solves the KZK equation in the frequency domain, is used to investigate the finite amplitude fields produced by rectangular transducers driven with short pulses and their inverses, in water and homogeneous tissue. This enables the characteristic of the fields and the effective PI field to be calculated. The suppression of the fundamental field in PI is monitored, and the suppression of side lobes and a reduction in the effective beamwidth for each field are calculated. In addition, the differences between the pulse and inverse pulse spectra resulting from the use of very short pulses are noted, and the differences in the location of the fundamental and second harmonic spectral peaks observed.

Wide Field Radio Transient Surveys

Science.gov (United States)

Bower, Geoffrey

2011-04-01

The time domain of the radio wavelength sky has been only sparsely explored. Nevertheless, serendipitous discovery and results from limited surveys indicate that there is much to be found on timescales from nanoseconds to years and at wavelengths from meters to millimeters. These observations have revealed unexpected phenomena such as rotating radio transients and coherent pulses from brown dwarfs. Additionally, archival studies have revealed an unknown class of radio transients without radio, optical, or high-energy hosts. The new generation of centimeter-wave radio telescopes such as the Allen Telescope Array (ATA) will exploit wide fields of view and flexible digital signal processing to systematically explore radio transient parameter space, as well as lay the scientific and technical foundation for the Square Kilometer Array. Known unknowns that will be the target of future transient surveys include orphan gamma-ray burst afterglows, radio supernovae, tidally-disrupted stars, flare stars, and magnetars. While probing the variable sky, these surveys will also provide unprecedented information on the static radio sky. I will present results from three large ATA surveys (the Fly's Eye survey, the ATA Twenty CM Survey (ATATS), and the Pi GHz Survey (PiGSS)) and several small ATA transient searches. Finally, I will discuss the landscape and opportunities for future instruments at centimeter wavelengths.

Photometric Calibration and Image Stitching for a Large Field of View Multi-Camera System

Directory of Open Access Journals (Sweden)

Yu Lu

2016-04-01

Full Text Available A new compact large field of view (FOV multi-camera system is introduced. The camera is based on seven tiny complementary metal-oxide-semiconductor sensor modules covering over 160° × 160° FOV. Although image stitching has been studied extensively, sensor and lens differences have not been considered in previous multi-camera devices. In this study, we have calibrated the photometric characteristics of the multi-camera device. Lenses were not mounted on the sensor in the process of radiometric response calibration to eliminate the influence of the focusing effect of uniform light from an integrating sphere. Linearity range of the radiometric response, non-linearity response characteristics, sensitivity, and dark current of the camera response function are presented. The R, G, and B channels have different responses for the same illuminance. Vignetting artifact patterns have been tested. The actual luminance of the object is retrieved by sensor calibration results, and is used to blend images to make panoramas reflect the objective luminance more objectively. This compensates for the limitation of stitching images that are more realistic only through the smoothing method. The dynamic range limitation of can be resolved by using multiple cameras that cover a large field of view instead of a single image sensor with a wide-angle lens. The dynamic range is expanded by 48-fold in this system. We can obtain seven images in one shot with this multi-camera system, at 13 frames per second.

Concept of dual-resolution light field imaging using an organic photoelectric conversion film for high-resolution light field photography.

Science.gov (United States)

Sugimura, Daisuke; Kobayashi, Suguru; Hamamoto, Takayuki

2017-11-01

Light field imaging is an emerging technique that is employed to realize various applications such as multi-viewpoint imaging, focal-point changing, and depth estimation. In this paper, we propose a concept of a dual-resolution light field imaging system to synthesize super-resolved multi-viewpoint images. The key novelty of this study is the use of an organic photoelectric conversion film (OPCF), which is a device that converts spectra information of incoming light within a certain wavelength range into an electrical signal (pixel value), for light field imaging. In our imaging system, we place the OPCF having the green spectral sensitivity onto the micro-lens array of the conventional light field camera. The OPCF allows us to acquire the green spectra information only at the center viewpoint with the full resolution of the image sensor. In contrast, the optical system of the light field camera in our imaging system captures the other spectra information (red and blue) at multiple viewpoints (sub-aperture images) but with low resolution. Thus, our dual-resolution light field imaging system enables us to simultaneously capture information about the target scene at a high spatial resolution as well as the direction information of the incoming light. By exploiting these advantages of our imaging system, our proposed method enables the synthesis of full-resolution multi-viewpoint images. We perform experiments using synthetic images, and the results demonstrate that our method outperforms other previous methods.

Low field-low cost: Can low-field magnetic resonance systems replace high-field magnetic resonance systems in the diagnostic assessment of multiple sclerosis patients?

International Nuclear Information System (INIS)

Ertl-Wagner, B.B.; Reith, W.; Sartor, K.

2001-01-01

As low-field MR imaging is becoming a widely used imaging technique, we aimed at a prospective assessment of differences in imaging quality between low- and high-field MR imaging in multiple sclerosis patients possibly interfering with diagnostic or therapeutic decision making. Twenty patients with clinically proven multiple sclerosis were examined with optimized imaging protocols in a 1.5- and a 0.23-T MR scanner within 48 h. Images were assessed independently by two neuroradiologists. No statistically significant interrater discrepancies were observed. A significantly lower number of white matter lesions could be identified in low-field MR imaging both on T1- and on T2-weighted images (T2: high field 700, low field 481; T1: high field 253, low field 177). A total of 114 enhancing lesions were discerned in the high-field MR imaging as opposed to 45 enhancing lesions in low-field MR imaging. Blood-brain barrier disruption was identified in 11 of 20 patients in the high-field MR imaging, but only in 4 of 20 patients in low-field MR imaging. Since a significantly lower lesion load is identified in low-field MR imaging than in high-field MR imaging, and blood-brain barrier disruption is frequently missed, caution must be exercised in interpreting a normal low-field MR imaging scan in a patient with clinical signs of multiple sclerosis and in interpreting a scan without enhancing lesions in a patient with known multiple sclerosis and clinical signs of exacerbation. (orig.)

VizieR Online Data Catalog: Isaac Newton Telescope Wide Field Survey (CASU 2002)

Science.gov (United States)

Cambridge Astronomical Survey Unit

2002-04-01

The INT Wide Field Survey (WFS) is using the Wide Field Camera (~0.3 square degrees) on the 2.5m Isaac Newton Telescope (INT). The project was initiated in August 1998 and is expected to have a duration of up to five years. Multicolour data will be obtained over 200+ square degrees to a typical depth of ~25 mag (u' through z'). The data is publically accessible via the Cambridge Astronomical Survey Unit to UK and NL communities from day one, with access to the rest of the world after one year. This observation log lists all observations older than the one year proprietary period. (1 data file).

Posterior Vitreous Detachment as Observed by Wide-Angle OCT Imaging.

Science.gov (United States)

Tsukahara, Mayuka; Mori, Keiko; Gehlbach, Peter L; Mori, Keisuke

2018-04-06

Posterior vitreous detachment (PVD) plays an important role in vitreoretinal interface disorders. Historically, observations of PVD using OCT have been limited to the macular region. The purpose of this study is to image the wide-angle vitreoretinal interface after PVD in normal subjects using montaged OCT images. An observational cross-sectional study. A total of 144 healthy eyes of 98 normal subjects aged 21 to 95 years (51.4±22.0 [mean ± standard deviation]). Montaged images of horizontal and vertical OCT scans through the fovea were obtained in each subject. Montaged OCT images. By using wide-angle OCT, we imaged the vitreoretinal interface from the macula to the periphery. PVD was classified into 5 stages: stage 0, no PVD (2 eyes, both aged 21 years); stage 1, peripheral PVD limited to paramacular to peripheral zones (88 eyes, mean age 38.9±16.2 years, mean ± standard deviation); stage 2, perifoveal PVD extending to the periphery (12 eyes, mean age 67.9±8.4 years); stage 3, peripapillary PVD with persistent vitreopapillary adhesion alone (7 eyes, mean age 70.9±11.9 years); stage 4, complete PVD (35 eyes, mean age 75.1±10.1 years). All stage 1 PVDs (100%) were observed in the paramacular to peripheral region where the vitreous gel adheres directly to the cortical vitreous and retinal surface. After progression to stage 2 PVD, the area of PVD extends posteriorly to the perifovea and anteriorly to the periphery. Vitreoschisis was observed in 41.2% at PVD initiation (stage 1a). Whereas prior work suggests that PVD originates in the perifoveal region and after the sixth decade, our observations demonstrate that (1) PVD first appears even in the third decade of life and gradually appears more extensively throughout life; (2) more than 40% of eyes without fundus diseases at their PVD initiation are associated with vitreoschisis; and (3) PVD is first noted primarily in the paramacular-peripheral region where vitreous gel adheres to the retinal surface and is

Improvement of Sidestream Dark Field Imaging with an Image Acquisition Stabilizer

International Nuclear Information System (INIS)

Balestra, Gianmarco M; Bezemer, Rick; Boerma, E Christiaan; Yong, Ze-Yie; Sjauw, Krishan D; Engstrom, Annemarie E; Koopmans, Matty; Ince, Can

2010-01-01

In the present study we developed, evaluated in volunteers, and clinically validated an image acquisition stabilizer (IAS) for Sidestream Dark Field (SDF) imaging. The IAS is a stainless steel sterilizable ring which fits around the SDF probe tip. The IAS creates adhesion to the imaged tissue by application of negative pressure. The effects of the IAS on the sublingual microcirculatory flow velocities, the force required to induce pressure artifacts (PA), the time to acquire a stable image, and the duration of stable imaging were assessed in healthy volunteers. To demonstrate the clinical applicability of the SDF setup in combination with the IAS, simultaneous bilateral sublingual imaging of the microcirculation were performed during a lung recruitment maneuver (LRM) in mechanically ventilated critically ill patients. One SDF device was operated handheld; the second was fitted with the IAS and held in position by a mechanic arm. Lateral drift, number of losses of image stability and duration of stable imaging of the two methods were compared. Five healthy volunteers were studied. The IAS did not affect microcirculatory flow velocities. A significantly greater force had to applied onto the tissue to induced PA with compared to without IAS (0.25 ± 0.15 N without vs. 0.62 ± 0.05 N with the IAS, p < 0.001). The IAS ensured an increased duration of a stable image sequence (8 ± 2 s without vs. 42 ± 8 s with the IAS, p < 0.001). The time required to obtain a stable image sequence was similar with and without the IAS. In eight mechanically ventilated patients undergoing a LRM the use of the IAS resulted in a significantly reduced image drifting and enabled the acquisition of significantly longer stable image sequences (24 ± 5 s without vs. 67 ± 14 s with the IAS, p = 0.006). The present study has validated the use of an IAS for improvement of SDF imaging by demonstrating that the IAS did not affect microcirculatory perfusion in the microscopic field of view. The IAS

An electronically tunable ultrafast laser source applied to fluorescence imaging and fluorescence lifetime imaging microscopy

International Nuclear Information System (INIS)

Dunsby, C; Lanigan, P M P; McGinty, J; Elson, D S; Requejo-Isidro, J; Munro, I; Galletly, N; McCann, F; Treanor, B; Oenfelt, B; Davis, D M; Neil, M A A; French, P M W

2004-01-01

Fluorescence imaging is used widely in microscopy and macroscopic imaging applications for fields ranging from biomedicine to materials science. A critical component for any fluorescence imaging system is the excitation source. Traditionally, wide-field systems use filtered thermal or arc-generated white light sources, while point scanning confocal microscope systems require spatially coherent (point-like) laser sources. Unfortunately, the limited range of visible wavelengths available from conventional laser sources constrains the design and usefulness of fluorescent probes in confocal microscopy. A 'hands-off' laser-like source, electronically tunable across the visible spectrum, would be invaluable for fluorescence imaging and provide new opportunities, e.g. automated excitation fingerprinting and in situ measurement of excitation cross-sections. Yet more information can be obtained using fluorescence lifetime imaging (FLIM), which requires that the light source be pulsed or rapidly modulated. We show how a white light continuum, generated by injecting femtosecond optical radiation into a micro-structured optical fibre, coupled with a simple prism-based tunable filter arrangement, can fulfil all these roles as a continuously electronically tunable (435-1150 nm) visible ultrafast light source in confocal, wide-field and FLIM systems

Nerve Fiber Flux Analysis Using Wide-Field Swept-Source Optical Coherence Tomography.

Science.gov (United States)

Tan, Ou; Liu, Liang; Liu, Li; Huang, David

2018-02-01

To devise a method to quantify nerve fibers over their arcuate courses over an extended peripapillary area using optical coherence tomography (OCT). Participants were imaged with 8 × 8-mm volumetric OCT scans centered at the optic disc. A new quantity, nerve fiber flux (NFF), represents the cross-sectional area transected perpendicular to the nerve fibers. The peripapillary area was divided into 64 tracks with equal flux. An iterative algorithm traced the trajectory of the tracks assuming that the relative distribution of the NFF was conserved with compensation for fiber connections to ganglion cells on the macular side. Average trajectory was averaged from normal eyes and use to calculate the NFF maps for glaucomatous eyes. The NFF maps were divided into eight sectors that correspond to visual field regions. There were 24 healthy and 10 glaucomatous eyes enrolled. The algorithm converged on similar patterns of NFL tracks for all healthy eyes. In glaucomatous eyes, NFF correlated with visual field sensitivity in the arcuate sectors (Spearman ρ = 0.53-0.62). Focal nerve fiber loss in glaucomatous eyes appeared as uniform tracks of NFF defects that followed the expected arcuate fiber trajectory. Using an algorithm based on the conservation of flux, we derived nerve fiber trajectories in the peripapillary area. The NFF map is useful for the visualization of focal defects and quantification of sector nerve fiber loss from wide-area volumetric OCT scans. NFF provides a cumulative measure of volumetric loss along nerve fiber tracks and could improve the detection of focal glaucoma damage.

Apertureless near-field/far-field CW two-photon microscope for biological and material imaging and spectroscopic applications.

Science.gov (United States)

Nowak, Derek B; Lawrence, A J; Sánchez, Erik J

2010-12-10

We present the development of a versatile spectroscopic imaging tool to allow for imaging with single-molecule sensitivity and high spatial resolution. The microscope allows for near-field and subdiffraction-limited far-field imaging by integrating a shear-force microscope on top of a custom inverted microscope design. The instrument has the ability to image in ambient conditions with optical resolutions on the order of tens of nanometers in the near field. A single low-cost computer controls the microscope with a field programmable gate array data acquisition card. High spatial resolution imaging is achieved with an inexpensive CW multiphoton excitation source, using an apertureless probe and simplified optical pathways. The high-resolution, combined with high collection efficiency and single-molecule sensitive optical capabilities of the microscope, are demonstrated with a low-cost CW laser source as well as a mode-locked laser source.

Field-portable pixel super-resolution colour microscope.

Directory of Open Access Journals (Sweden)

Alon Greenbaum

Full Text Available Based on partially-coherent digital in-line holography, we report a field-portable microscope that can render lensfree colour images over a wide field-of-view of e.g., >20 mm(2. This computational holographic microscope weighs less than 145 grams with dimensions smaller than 17×6×5 cm, making it especially suitable for field settings and point-of-care use. In this lensfree imaging design, we merged a colorization algorithm with a source shifting based multi-height pixel super-resolution technique to mitigate 'rainbow' like colour artefacts that are typical in holographic imaging. This image processing scheme is based on transforming the colour components of an RGB image into YUV colour space, which separates colour information from brightness component of an image. The resolution of our super-resolution colour microscope was characterized using a USAF test chart to confirm sub-micron spatial resolution, even for reconstructions that employ multi-height phase recovery to handle dense and connected objects. To further demonstrate the performance of this colour microscope Papanicolaou (Pap smears were also successfully imaged. This field-portable and wide-field computational colour microscope could be useful for tele-medicine applications in resource poor settings.

Imaging strategies using focusing functions with applications to a North Sea field

Science.gov (United States)

da Costa Filho, C. A.; Meles, G. A.; Curtis, A.; Ravasi, M.; Kritski, A.

2018-04-01

Seismic methods are used in a wide variety of contexts to investigate subsurface Earth structures, and to explore and monitor resources and waste-storage reservoirs in the upper ˜100 km of the Earth's subsurface. Reverse-time migration (RTM) is one widely used seismic method which constructs high-frequency images of subsurface structures. Unfortunately, RTM has certain disadvantages shared with other conventional single-scattering-based methods, such as not being able to correctly migrate multiply scattered arrivals. In principle, the recently developed Marchenko methods can be used to migrate all orders of multiples correctly. In practice however, using Marchenko methods are costlier to compute than RTM—for a single imaging location, the cost of performing the Marchenko method is several times that of standard RTM, and performing RTM itself requires dedicated use of some of the largest computers in the world for individual data sets. A different imaging strategy is therefore required. We propose a new set of imaging methods which use so-called focusing functions to obtain images with few artifacts from multiply scattered waves, while greatly reducing the number of points across the image at which the Marchenko method need be applied. Focusing functions are outputs of the Marchenko scheme: they are solutions of wave equations that focus in time and space at particular surface or subsurface locations. However, they are mathematical rather than physical entities, being defined only in reference media that equal to the true Earth above their focusing depths but are homogeneous below. Here, we use these focusing functions as virtual source/receiver surface seismic surveys, the upgoing focusing function being the virtual received wavefield that is created when the downgoing focusing function acts as a spatially distributed source. These source/receiver wavefields are used in three imaging schemes: one allows specific individual reflectors to be selected and imaged

UNUSUALLY WIDE BINARIES: ARE THEY WIDE OR UNUSUAL?

International Nuclear Information System (INIS)

Kraus, Adam L.; Hillenbrand, Lynne A.

2009-01-01

We describe an astrometric and spectroscopic campaign to confirm the youth and association of a complete sample of candidate wide companions in Taurus and Upper Sco. Our survey found 15 new binary systems (three in Taurus and 12 in Upper Sco) with separations of 3''-30'' (500-5000 AU) among all of the known members with masses of 2.5-0.012 M sun . The total sample of 49 wide systems in these two regions conforms to only some expectations from field multiplicity surveys. Higher mass stars have a higher frequency of wide binary companions, and there is a marked paucity of wide binary systems near the substellar regime. However, the separation distribution appears to be log-flat, rather than declining as in the field, and the mass ratio distribution is more biased toward similar-mass companions than the initial mass function or the field G-dwarf distribution. The maximum separation also shows no evidence of a limit at ∼ sun . We attribute this result to the post-natal dynamical sculpting that occurs for most field systems; our binary systems will escape to the field intact, but most field stars are formed in denser clusters and undergo significant dynamical evolution. In summary, only wide binary systems with total masses ∼ sun appear to be 'unusually wide'.

CONFIRMATION OF THE COMPACTNESS OF A z = 1.91 QUIESCENT GALAXY WITH HUBBLE SPACE TELESCOPE'S WIDE FIELD CAMERA 3

International Nuclear Information System (INIS)

Szomoru, Daniel; Franx, Marijn; Bouwens, Rychard J.; Van Dokkum, Pieter G.; Trenti, Michele; Illingworth, Garth D.; Labbe, Ivo; Oesch, Pascal A.; Carollo, C. Marcella

2010-01-01

We present very deep Wide Field Camera 3 (WFC3) photometry of a massive, compact galaxy located in the Hubble Ultra Deep Field. This quiescent galaxy has a spectroscopic redshift z = 1.91 and has been identified as an extremely compact galaxy by Daddi et al. We use new H F160W imaging data obtained with Hubble Space Telescope/WFC3 to measure the deconvolved surface brightness profile to H ∼ 28 mag arcsec -2 . We find that the surface brightness profile is well approximated by an n = 3.7 Sersic profile. Our deconvolved profile is constructed by a new technique which corrects the best-fit Sersic profile with the residual of the fit to the observed image. This allows for galaxy profiles which deviate from a Sersic profile. We determine the effective radius of this galaxy: r e = 0.42 ± 0.14 kpc in the observed H F160W band. We show that this result is robust to deviations from the Sersic model used in the fit. We test the sensitivity of our analysis to faint 'wings' in the profile using simulated galaxy images consisting of a bright compact component and a faint extended component. We find that due to the combination of the WFC3 imaging depth and our method's sensitivity to extended faint emission we can accurately trace the intrinsic surface brightness profile, and that we can therefore confidently rule out the existence of a faint extended envelope around the observed galaxy down to our surface brightness limit. These results confirm that the galaxy lies a factor ∼10 off from the local mass-size relation.

3D fingerprint imaging system based on full-field fringe projection profilometry

Science.gov (United States)

Huang, Shujun; Zhang, Zonghua; Zhao, Yan; Dai, Jie; Chen, Chao; Xu, Yongjia; Zhang, E.; Xie, Lili

2014-01-01

As an unique, unchangeable and easily acquired biometrics, fingerprint has been widely studied in academics and applied in many fields over the years. The traditional fingerprint recognition methods are based on the obtained 2D feature of fingerprint. However, fingerprint is a 3D biological characteristic. The mapping from 3D to 2D loses 1D information and causes nonlinear distortion of the captured fingerprint. Therefore, it is becoming more and more important to obtain 3D fingerprint information for recognition. In this paper, a novel 3D fingerprint imaging system is presented based on fringe projection technique to obtain 3D features and the corresponding color texture information. A series of color sinusoidal fringe patterns with optimum three-fringe numbers are projected onto a finger surface. From another viewpoint, the fringe patterns are deformed by the finger surface and captured by a CCD camera. 3D shape data of the finger can be obtained from the captured fringe pattern images. This paper studies the prototype of the 3D fingerprint imaging system, including principle of 3D fingerprint acquisition, hardware design of the 3D imaging system, 3D calibration of the system, and software development. Some experiments are carried out by acquiring several 3D fingerprint data. The experimental results demonstrate the feasibility of the proposed 3D fingerprint imaging system.

Defect Characterization, Imaging, and Control in Wide-Bandgap Semiconductors and Devices

Science.gov (United States)

Brillson, L. J.; Foster, G. M.; Cox, J.; Ruane, W. T.; Jarjour, A. B.; Gao, H.; von Wenckstern, H.; Grundmann, M.; Wang, B.; Look, D. C.; Hyland, A.; Allen, M. W.

2018-03-01

Wide-bandgap semiconductors are now leading the way to new physical phenomena and device applications at nanoscale dimensions. The impact of defects on the electronic properties of these materials increases as their size decreases, motivating new techniques to characterize and begin to control these electronic states. Leading these advances have been the semiconductors ZnO, GaN, and related materials. This paper highlights the importance of native point defects in these semiconductors and describes how a complement of spatially localized surface science and spectroscopy techniques in three dimensions can characterize, image, and begin to control these electronic states at the nanoscale. A combination of characterization techniques including depth-resolved cathodoluminescence spectroscopy, surface photovoltage spectroscopy, and hyperspectral imaging can describe the nature and distribution of defects at interfaces at both bulk and nanoscale surfaces, their metal interfaces, and inside nanostructures themselves. These features as well as temperature and mechanical strain inside wide-bandgap device structures at the nanoscale can be measured even while these devices are operating. These advanced capabilities enable several new directions for describing defects at the nanoscale, showing how they contribute to device degradation, and guiding growth processes to control them.

The mean field theory in EM procedures for blind Markov random field image restoration.

Science.gov (United States)

Zhang, J

1993-01-01

A Markov random field (MRF) model-based EM (expectation-maximization) procedure for simultaneously estimating the degradation model and restoring the image is described. The MRF is a coupled one which provides continuity (inside regions of smooth gray tones) and discontinuity (at region boundaries) constraints for the restoration problem which is, in general, ill posed. The computational difficulty associated with the EM procedure for MRFs is resolved by using the mean field theory from statistical mechanics. An orthonormal blur decomposition is used to reduce the chances of undesirable locally optimal estimates. Experimental results on synthetic and real-world images show that this approach provides good blur estimates and restored images. The restored images are comparable to those obtained by a Wiener filter in mean-square error, but are most visually pleasing.

Objective and expert-independent validation of retinal image registration algorithms by a projective imaging distortion model

NARCIS (Netherlands)

Lee, Sangyeol; Reinhardt, Joseph M.; Cattin, Philippe C.; Abramoff, M.D.

2010-01-01

Fundus camera imaging of the retina is widely used to diagnose and manage ophthalmologic disorders including diabetic retinopathy, glaucoma, and age-related macular degeneration. Retinal images typically have a limited field of view, and multiple images can be joined together using an image

Hubble Space Telescope Wide Field Planetary Camera 2 Observations of Neptune

Science.gov (United States)

1995-01-01

Two groups have recently used the Hubble Space Telescope (HST) Wide Field Planetary Camera 2 (WFPC 2) to acquire new high-resolution images of the planet Neptune. Members of the WFPC-2 Science Team, lead by John Trauger, acquired the first series of images on 27 through 29 June 1994. These were the highest resolution images of Neptune taken since the Voyager-2 flyby in August of 1989. A more comprehensive program is currently being conducted by Heidi Hammel and Wes Lockwood. These two sets of observations are providing a wealth of new information about the structure, composition, and meteorology of this distant planet's atmosphere.Neptune is currently the most distant planet from the sun, with an orbital radius of 4.5 billion kilometers (2.8 billion miles, or 30 Astronomical Units). Even though its diameter is about four times that of the Earth (49,420 vs. 12,742 km), ground-based telescopes reveal a tiny blue disk that subtends less than 1/1200 of a degree (2.3 arc-seconds). Neptune has therefore been a particularly challenging object to study from the ground because its disk is badly blurred by the Earth's atmosphere. In spite of this, ground-based astronomers had learned a great deal about this planet since its position was first predicted by John C. Adams and Urbain Leverrier in 1845. For example, they had determined that Neptune was composed primarily of hydrogen and helium gas, and that its blue color caused by the presence of trace amounts of the gas methane, which absorbs red light. They had also detected bright cloud features whose brightness changed with time, and tracked these clouds to infer a rotation period between 17 and 22 hours.When the Voyager-2 spacecraft flew past the Neptune in 1989, its instruments revealed a surprising array of meteorological phenomena, including strong winds, bright, high-altitude clouds, and two large dark spots attributed to long-lived giant storm systems. These bright clouds and dark spots were tracked as they moved

Ultra wide band radar holographic imaging of buried waste at DOE sites

International Nuclear Information System (INIS)

Collins, H.D.; Gribble, R.P.; Hall, T.E.; Lechelt, W.M.

1995-04-01

Ultra wideband linear array holography is a unique real-time imaging technique for in-situ inspection of buried waste at various DOE sites. The array can be mounted on various platforms such as crane booms, pickup trucks, ATVs, and scanned generating ''3-D'' subsurface images in real time. Inspection speeds are 0.5 to 2 meters/sec, if the image is viewed in real time, greater for off-line processing. The Ground Penetrating Holographic (GPH) system developed for inspection of DOE sites employs two 32element arrays of tapered-slot antenna operating at 5-GHz and 2.5-GHz center frequencies. The GPH system, which is mounted on a small trailer with a computer image processor, display, and power supply, is capable of imaging a wide swath (1 to 2 meters) with its linear arrays. The lower frequency array will be used at INEL (for greater depth penetration) because of high soil attenuation. Recent holographic ''3-D'' images of buried waste container lids and dielectrics obtained in Hanford sand and INEL soils at various depths graphically illustrate the unique image resolution capabilities of the system. Experimental results using the 5-GHz array will be presented showing the excellent holographic image quality of various subsurface targets in sand and INEL soil

Functionality of veterinary identification microchips following low- (0.5 tesla) and high-field (3 tesla) magnetic resonance imaging.

Science.gov (United States)

Piesnack, Susann; Frame, Mairi E; Oechtering, Gerhard; Ludewig, Eberhard

2013-01-01

The ability to read patient identification microchips relies on the use of radiofrequency pulses. Since radiofrequency pulses also form an integral part of the magnetic resonance imaging (MRI) process, the possibility of loss of microchip function during MRI scanning is of concern. Previous clinical trials have shown microchip function to be unaffected by MR imaging using a field strength of 1 Tesla and 1.5. As veterinary MRI scanners range widely in field strength, this study was devised to determine whether exposure to lower or higher field strengths than 1 Tesla would affect the function of different types of microchip. In a phantom study, a total of 300 International Standards Organisation (ISO)-approved microchips (100 each of three different types: ISO FDX-B 1.4 × 9 mm, ISO FDX-B 2.12 × 12 mm, ISO HDX 3.8 × 23 mm) were tested in a low field (0.5) and a high field scanner (3.0 Tesla). A total of 50 microchips of each type were tested in each scanner. The phantom was composed of a fluid-filled freezer pack onto which a plastic pillow and a cardboard strip with affixed microchips were positioned. Following an MRI scan protocol simulating a head study, all of the microchips were accurately readable. Neither 0.5 nor 3 Tesla imaging affected microchip function in this study. © 2013 Veterinary Radiology & Ultrasound.

THz near-field imaging of biological tissues employing synchrotron radiation

International Nuclear Information System (INIS)

Schade, Ulrich; Holldack, Karsten; Martin, Michael C.; Fried, Daniel

2004-01-01

Terahertz scanning near-field infrared microscopy (SNIM) below 1 THz is demonstrated. The near-field technique benefits from the broadband and highly brilliant coherent synchrotron radiation (CSR) from an electron storage ring and from a detection method based on locking onto the intrinsic time structure of the synchrotron radiation. The scanning microscope utilizes conical wave guides as near-field probes with apertures smaller than the wavelength. Different cone approaches have been investigated to obtain maximum transmittance. Together with a Martin-Puplett spectrometer the set-up enables spectroscopic mapping of the transmittance of samples well below the diffraction limit. Spatial resolution down to about lambda/40 at 2 wavenumbers (0.06 THz) is derived from the transmittance spectra of the near-field probes. The potential of the technique is exemplified by imaging biological samples. Strongly absorbing living leaves have been imaged in transmittance with a spatial resolution of 130 mu-m at about 12 wave numbers (0.36 THz). The THz near-field images reveal distinct structural differences of leaves from different plants investigated. The technique presented also allows spectral imaging of bulky organic tissues. Human teeth samples of various thicknesses have been imaged between 2 and 20 wavenumbers (between 0.06and 0.6 THz). Regions of enamel and dentin within tooth samples are spatially and spectrally resolved, and buried caries lesions are imaged through both the outer enamel and into the underlying dentin

The impact of digital imaging in the field of cytopathology.

Science.gov (United States)

Pantanowitz, Liron; Hornish, Maryanne; Goulart, Robert A

2009-03-06

With the introduction of digital imaging, pathology is undergoing a digital transformation. In the field of cytology, digital images are being used for telecytology, automated screening of Pap test slides, training and education (e.g. online digital atlases), and proficiency testing. To date, there has been no systematic review on the impact of digital imaging on the practice of cytopathology. This article critically addresses the emerging role of computer-assisted screening and the application of digital imaging to the field of cytology, including telecytology, virtual microscopy, and the impact of online cytology resources. The role of novel diagnostic techniques like image cytometry is also reviewed.

Slice-based supine-to-standing posture deformation for chinese anatomical models and the dosimetric results with wide band frequency electromagnetic field exposure: Simulation

International Nuclear Information System (INIS)

Wu, T.; Tan, L.; Shao, Q.; Li, Y.; Yang, L.; Zhao, C.; Xie, Y.; Zhang, S.

2013-01-01

Standing Chinese adult anatomical models are obtained from supine-postured cadaver slices. This paper presents the dosimetric differences between the supine and the standing postures over wide band frequencies and various incident configurations. Both the body level and the tissue/organ level differences are reported for plane wave and the 3T magnetic resonance imaging radiofrequency electromagnetic field exposure. The influence of posture on the whole body specific absorption rate and tissue specified specific absorption rate values is discussed. . (authors)

Invited Article: First Flight in Space of a Wide-field-of-view Soft X-Ray Imager Using Lobster-Eye Optics: Instrument Description and Initial Flight Results

Science.gov (United States)

Collier, Michael; Porter, F. Scott; Sibeck, David G.; Carter, Jenny A.; Chiao, Meng P.; Chomay, Dennis J.; Cravens, Thomas E.; Galeazzi, Massiniliano; Keller, John; Koutroumpa, Dimitra

2015-01-01

We describe the development, launch into space, and initial results from a prototype wide eld-of-view (FOV) soft X-ray imager that employs Lobster-eye optics and targets heliophysics, planetary, and astrophysics science. The Sheath Transport Observer for the Redistribution of Mass (STORM) is the rst instrument using this type of optics launched into space and provides proof-of-concept for future ight instruments capable of imaging structures such as the terrestrial cusp, the entire dayside magnetosheath from outside the magnetosphere, comets, the moon, and the solar wind interaction with planetary bodies like Venus and Mars.

Extended depth of field integral imaging using multi-focus fusion

Science.gov (United States)

Piao, Yongri; Zhang, Miao; Wang, Xiaohui; Li, Peihua

2018-03-01

In this paper, we propose a new method for depth of field extension in integral imaging by realizing the image fusion method on the multi-focus elemental images. In the proposed method, a camera is translated on a 2D grid to take multi-focus elemental images by sweeping the focus plane across the scene. Simply applying an image fusion method on the elemental images holding rich parallax information does not work effectively because registration accuracy of images is the prerequisite for image fusion. To solve this problem an elemental image generalization method is proposed. The aim of this generalization process is to geometrically align the objects in all elemental images so that the correct regions of multi-focus elemental images can be exacted. The all-in focus elemental images are then generated by fusing the generalized elemental images using the block based fusion method. The experimental results demonstrate that the depth of field of synthetic aperture integral imaging system has been extended by realizing the generation method combined with the image fusion on multi-focus elemental images in synthetic aperture integral imaging system.

Superresolution Near-field Imaging with Surface Waves

KAUST Repository

Fu, Lei

2017-10-21

We present the theory for near-field superresolution imaging with surface waves and time reverse mirrors (TRMs). Theoretical formulas and numerical results show that applying the TRM operation to surface waves in an elastic half-space can achieve superresolution imaging of subwavelength scatterers if they are located less than about 1/2 of the shear wavelength from the source line. We also show that the TRM operation for a single frequency is equivalent to natural migration, which uses the recorded data to approximate the Green’s functions for migration, and only costs O(N4) algebraic operations for poststack migration compared to O(N6) operations for natural prestack migration. Here, we assume the sources and receivers are on an N × N grid and there are N2 trial image points on the free surface. Our theoretical predictions of superresolution are validated with tests on synthetic data. The field-data tests suggest that hidden faults at the near surface can be detected with subwavelength imaging of surface waves by using the TRM operation if they are no deeper than about 1/2 the dominant shear wavelength.

Simultaneous near field imaging of electric and magnetic field in photonic crystal nanocavities

NARCIS (Netherlands)

Vignolini, S.; Intonti, F.; Riboli, F.; Wiersma, D.S.; Balet, L.P.; Li, L.H.; Francardi, M.; Gerardino, A.; Fiore, A.; Gurioli, M.

2012-01-01

The insertion of a metal-coated tip on the surface of a photonic crystal microcavity is used for simultaneous near field imaging of electric and magnetic fields in photonic crystal nanocavities, via the radiative emission of embedded semiconductor quantum dots (QD). The photoluminescence intensity

A tool for NDVI time series extraction from wide-swath remotely sensed images

Science.gov (United States)

Li, Zhishan; Shi, Runhe; Zhou, Cong

2015-09-01

Normalized Difference Vegetation Index (NDVI) is one of the most widely used indicators for monitoring the vegetation coverage in land surface. The time series features of NDVI are capable of reflecting dynamic changes of various ecosystems. Calculating NDVI via Moderate Resolution Imaging Spectrometer (MODIS) and other wide-swath remotely sensed images provides an important way to monitor the spatial and temporal characteristics of large-scale NDVI. However, difficulties are still existed for ecologists to extract such information correctly and efficiently because of the problems in several professional processes on the original remote sensing images including radiometric calibration, geometric correction, multiple data composition and curve smoothing. In this study, we developed an efficient and convenient online toolbox for non-remote sensing professionals who want to extract NDVI time series with a friendly graphic user interface. It is based on Java Web and Web GIS technically. Moreover, Struts, Spring and Hibernate frameworks (SSH) are integrated in the system for the purpose of easy maintenance and expansion. Latitude, longitude and time period are the key inputs that users need to provide, and the NDVI time series are calculated automatically.

The Fresnel Zone Light Field Spectral Imager

Science.gov (United States)

2017-03-23

detection efficiency for weak signals . Additionally, further study should be done on spectral calibration methods for a FZLFSI. When dealing with weak ... detection assembly. The different image formation planes for each wavelength are constructed synthetically through processing the collected light ...a single micro-lens image. This character- istic also holds for wavelengths other than the design wavelength. 36 modified light field PSF is detected

Computer-aided discovery of debris disk candidates: A case study using the Wide-Field Infrared Survey Explorer (WISE) catalog

Science.gov (United States)

Nguyen, T.; Pankratius, V.; Eckman, L.; Seager, S.

2018-04-01

Debris disks around stars other than the Sun have received significant attention in studies of exoplanets, specifically exoplanetary system formation. Since debris disks are major sources of infrared emissions, infrared survey data such as the Wide-Field Infrared Survey (WISE) catalog potentially harbors numerous debris disk candidates. However, it is currently challenging to perform disk candidate searches for over 747 million sources in the WISE catalog due to the high probability of false positives caused by interstellar matter, galaxies, and other background artifacts. Crowdsourcing techniques have thus started to harness citizen scientists for debris disk identification since humans can be easily trained to distinguish between desired artifacts and irrelevant noises. With a limited number of citizen scientists, however, increasing data volumes from large surveys will inevitably lead to analysis bottlenecks. To overcome this scalability problem and push the current limits of automated debris disk candidate identification, we present a novel approach that uses citizen science results as a seed to train machine learning based classification. In this paper, we detail a case study with a computer-aided discovery pipeline demonstrating such feasibility based on WISE catalog data and NASA's Disk Detective project. Our approach of debris disk candidates classification was shown to be robust under a wide range of image quality and features. Our hybrid approach of citizen science with algorithmic scalability can facilitate big data processing for future detections as envisioned in future missions such as the Transiting Exoplanet Survey Satellite (TESS) and the Wide-Field Infrared Survey Telescope (WFIRST).

Nanohybrids Near-Field Optical Microscopy: From Image Shift to Biosensor Application

Directory of Open Access Journals (Sweden)

Nayla El-Kork

2016-01-01

Full Text Available Near-Field Optical Microscopy is a valuable tool for the optical and topographic study of objects at a nanometric scale. Nanoparticles constitute important candidates for such type of investigations, as they bear an important weight for medical, biomedical, and biosensing applications. One, however, has to be careful as artifacts can be easily reproduced. In this study, we examined hybrid nanoparticles (or nanohybrids in the near-field, while in solution and attached to gold nanoplots. We found out that they can be used for wavelength modulable near-field biosensors within conditions of artifact free imaging. In detail, we refer to the use of topographic/optical image shift and the imaging of Local Surface Plasmon hot spots to validate the genuineness of the obtained images. In summary, this study demonstrates a new way of using simple easily achievable comparative methods to prove the authenticity of near-field images and presents nanohybrid biosensors as an application.

Multichannel High Resolution Wide Swath SAR Imaging for Hypersonic Air Vehicle with Curved Trajectory

Directory of Open Access Journals (Sweden)

Rui Zhou

2018-01-01

Full Text Available Synthetic aperture radar (SAR equipped on the hypersonic air vehicle in near space has many advantages over the conventional airborne SAR. However, its high-speed maneuvering characteristics with curved trajectory result in serious range migration, and exacerbate the contradiction between the high resolution and wide swath. To solve this problem, this paper establishes the imaging geometrical model matched with the flight trajectory of the hypersonic platform and the multichannel azimuth sampling model based on the displaced phase center antenna (DPCA technology. Furthermore, based on the multichannel signal reconstruction theory, a more efficient spectrum reconstruction model using discrete Fourier transform is proposed to obtain the azimuth uniform sampling data. Due to the high complexity of the slant range model, it is difficult to deduce the processing algorithm for SAR imaging. Thus, an approximate range model is derived based on the minimax criterion, and the optimal second-order approximate coefficients of cosine function are obtained using the two-population coevolutionary algorithm. On this basis, aiming at the problem that the traditional Omega-K algorithm cannot compensate the residual phase with the difficulty of Stolt mapping along the range frequency axis, this paper proposes an Exact Transfer Function (ETF algorithm for SAR imaging, and presents a method of range division to achieve wide swath imaging. Simulation results verify the effectiveness of the ETF imaging algorithm.

Multichannel High Resolution Wide Swath SAR Imaging for Hypersonic Air Vehicle with Curved Trajectory.

Science.gov (United States)

Zhou, Rui; Sun, Jinping; Hu, Yuxin; Qi, Yaolong

2018-01-31

Synthetic aperture radar (SAR) equipped on the hypersonic air vehicle in near space has many advantages over the conventional airborne SAR. However, its high-speed maneuvering characteristics with curved trajectory result in serious range migration, and exacerbate the contradiction between the high resolution and wide swath. To solve this problem, this paper establishes the imaging geometrical model matched with the flight trajectory of the hypersonic platform and the multichannel azimuth sampling model based on the displaced phase center antenna (DPCA) technology. Furthermore, based on the multichannel signal reconstruction theory, a more efficient spectrum reconstruction model using discrete Fourier transform is proposed to obtain the azimuth uniform sampling data. Due to the high complexity of the slant range model, it is difficult to deduce the processing algorithm for SAR imaging. Thus, an approximate range model is derived based on the minimax criterion, and the optimal second-order approximate coefficients of cosine function are obtained using the two-population coevolutionary algorithm. On this basis, aiming at the problem that the traditional Omega-K algorithm cannot compensate the residual phase with the difficulty of Stolt mapping along the range frequency axis, this paper proposes an Exact Transfer Function (ETF) algorithm for SAR imaging, and presents a method of range division to achieve wide swath imaging. Simulation results verify the effectiveness of the ETF imaging algorithm.

The HST/WFC3 Quicklook Project: A User Interface to Hubble Space Telescope Wide Field Camera 3 Data

Science.gov (United States)

Bourque, Matthew; Bajaj, Varun; Bowers, Ariel; Dulude, Michael; Durbin, Meredith; Gosmeyer, Catherine; Gunning, Heather; Khandrika, Harish; Martlin, Catherine; Sunnquist, Ben; Viana, Alex

2017-06-01

The Hubble Space Telescope's Wide Field Camera 3 (WFC3) instrument, comprised of two detectors, UVIS (Ultraviolet-Visible) and IR (Infrared), has been acquiring ~ 50-100 images daily since its installation in 2009. The WFC3 Quicklook project provides a means for instrument analysts to store, calibrate, monitor, and interact with these data through the various Quicklook systems: (1) a ~ 175 TB filesystem, which stores the entire WFC3 archive on disk, (2) a MySQL database, which stores image header data, (3) a Python-based automation platform, which currently executes 22 unique calibration/monitoring scripts, (4) a Python-based code library, which provides system functionality such as logging, downloading tools, database connection objects, and filesystem management, and (5) a Python/Flask-based web interface to the Quicklook system. The Quicklook project has enabled large-scale WFC3 analyses and calibrations, such as the monitoring of the health and stability of the WFC3 instrument, the measurement of ~ 20 million WFC3/UVIS Point Spread Functions (PSFs), the creation of WFC3/IR persistence calibration products, and many others.

Spin imaging in solids using synchronously rotating field gradients and samples

International Nuclear Information System (INIS)

Wind, R.A.; Yannoni, C.S.

1983-01-01

A method for spin-imaging in solids using nuclear magnetic resonance (NMR) spectroscopy is described. With this method, the spin density distribution of a two- or three-dimensional object such as a solid can be constructed resulting in an image of the sample. This method lends itself to computer control to map out an image of the object. This spin-imaging method involves the steps of placing a solid sample in the rf coil field and the external magnetic field of an NMR spectrometer. A magnetic field gradient is superimposed across the sample to provide a field gradient which results in a varying DC field that has different values over different parts of the sample. As a result, nuclei in different parts of the sample have different resonant NMR frequencies. The sample is rotated about an axis which makes a particular angle of 54.7 degrees with the static external magnetic field. The magnetic field gradient which has a spatial distribution related to the sample spinning axis is then rotated synchronously with the sample. Data is then collected while performing a solid state NMR line narrowing procedure. The next step is to change the phase relation between the sample rotation and the field gradient rotation. The data is again collected as before while the sample and field gradient are synchronously rotated. The phase relation is changed a number of times and data collected each time. The spin image of the solid sample is then reconstructed from the collected data

Polarization leakage in epoch of reionization windows - III. Wide-field effects of narrow-field arrays

Science.gov (United States)

Asad, K. M. B.; Koopmans, L. V. E.; Jelić, V.; de Bruyn, A. G.; Pandey, V. N.; Gehlot, B. K.

2018-05-01

Leakage of polarized Galactic diffuse emission into total intensity can potentially mimic the 21-cm signal coming from the epoch of reionization (EoR), as both of them might have fluctuating spectral structure. Although we are sensitive to the EoR signal only in small fields of view, chromatic side-lobes from further away can contaminate the inner region. Here, we explore the effects of leakage into the `EoR window' of the cylindrically averaged power spectra (PS) within wide fields of view using both observation and simulation of the 3C196 and North Celestial Pole (NCP) fields, two observing fields of the LOFAR-EoR project. We present the polarization PS of two one-night observations of the two fields and find that the NCP field has higher fluctuations along frequency, and consequently exhibits more power at high-k∥ that could potentially leak to Stokes I. Subsequently, we simulate LOFAR observations of Galactic diffuse polarized emission based on a model to assess what fraction of polarized power leaks into Stokes I because of the primary beam. We find that the rms fractional leakage over the instrumental k-space is 0.35 {per cent} in the 3C196 field and 0.27 {per cent} in the NCP field, and it does not change significantly within the diameters of 15°, 9°, and 4°. Based on the observed PS and simulated fractional leakage, we show that a similar level of leakage into Stokes I is expected in the 3C196 and NCP fields, and the leakage can be considered to be a bias in the PS.

Fourier-transform ghost imaging with pure far-field correlated thermal light

International Nuclear Information System (INIS)

Liu Honglin; Shen Xia; Han Shensheng; Zhu Daming

2007-01-01

Pure far-field correlated thermal light beams are created with phase grating, and Fourier-transform ghost imaging depending only on the far-field correlation is demonstrated experimentally. Theoretical analysis and the results of experimental investigation of this pure far-field correlated thermal light are presented. Applications which may be exploited with this imaging scheme are discussed

Wide field monitoring of the X-ray sky using Rotation Modulation Collimators

DEFF Research Database (Denmark)

Lund, Niels; Brandt, Søren

1995-01-01

Wide field monitoring is of particular interest in X-ray astronomy due to the strong time-variability of most X-ray sources. Not only does the time-profiles of the persistent sources contain characteristic signatures of the underlying physical systems, but, additionally, some of the most intrigui...

Hyperspectral image analysis for the determination of alteration minerals in geothermal fields: Çürüksu (Denizli) Graben, Turkey

Science.gov (United States)

Uygur, Merve; Karaman, Muhittin; Kumral, Mustafa

2016-04-01

Çürüksu (Denizli) Graben hosts various geothermal fields such as Kızıldere, Yenice, Gerali, Karahayıt, and Tekkehamam. Neotectonic activities, which are caused by extensional tectonism, and deep circulation in sub-volcanic intrusions are heat sources of hydrothermal solutions. The temperature of hydrothermal solutions is between 53 and 260 degree Celsius. Phyllic, argillic, silicic, and carbonatization alterations and various hydrothermal minerals have been identified in various research studies of these areas. Surfaced hydrothermal alteration minerals are one set of potential indicators of geothermal resources. Developing the exploration tools to define the surface indicators of geothermal fields can assist in the recognition of geothermal resources. Thermal and hyperspectral imaging and analysis can be used for defining the surface indicators of geothermal fields. This study tests the hypothesis that hyperspectral image analysis based on EO-1 Hyperion images can be used for the delineation and definition of surfaced hydrothermal alteration in geothermal fields. Hyperspectral image analyses were applied to images covering the geothermal fields whose alteration characteristic are known. To reduce data dimensionality and identify spectral endmembers, Kruse's multi-step process was applied to atmospherically and geometrically-corrected hyperspectral images. Minimum Noise Fraction was used to reduce the spectral dimensions and isolate noise in the images. Extreme pixels were identified from high order MNF bands using the Pixel Purity Index. n-Dimensional Visualization was utilized for unique pixel identification. Spectral similarities between pixel spectral signatures and known endmember spectrum (USGS Spectral Library) were compared with Spectral Angle Mapper Classification. EO-1 Hyperion hyperspectral images and hyperspectral analysis are sensitive to hydrothermal alteration minerals, as their diagnostic spectral signatures span the visible and shortwave

WISE: The Wide-field Infrared Survey Explorer

Science.gov (United States)

Eisenhardt, Peter R.; Wright, E. L.; Benford, D.; Blain, A.; Cohen, M.; Cutri, R.; Gautier, T. N.; Jarrett, T.; Kirkpatrick, J. D.; Leisawitz, D.; Lonsdale, C.; Mainzer, A.; Mather, J.; McLean, I.; McMillan, R.; Mendez, B.; Padgett, D.; Ressler, M.; Skrutskie, M.; Stanford, S. A.; Walker, R.

2009-01-01

WISE will map the entire sky at 3.3, 4.7, 12 and 23 microns with sensitivities of 0.12, 0.16. 0.65, and 2.6 mJy. WISE will find the most luminous galaxies in the universe, the closest stars to the Sun, and detect most main belt asteroids larger than 3 km. WISE will be placed into a Sun-synchronous polar orbit on a Delta 7320-10 rocket, rotating at a constant rate while a scan mirror freezes the line of sight during each exposure, covering the sky in 6 months following a one month checkout. Orbit to orbit overlap provides 8 or more exposures at each location. The instrument, provided by the Space Dynamics Laboratory, includes an all-reflective aluminum telescope with a 40 cm primary built by SSG-Tinsley, a solid hydrogen cryostat built by Lockheed-Martin's Advanced Technology Center, and 1024x1024 pixel Si:As and HgCdTe arrays built by DRS and Teledyne. Dichroic beamsplitters allow simultaneous images in the four bands over a 47'x47' field of view with 5" resolution to be obtained every 11 seconds. Ball Aerospace is providing the spacecraft, including a 500W fixed solar array, Li-ion battery, two star trackers, reaction wheels, and torque rods. The 50 GB per day of images are losslessly compressed, stored in flash memory, and downlinked at 100 Mbps four times per day using a fixed antenna and TDRSS satellites. The Infrared Processing and Analysis Center will process the data and deliver the image atlas and source catalog, with a preliminary release 6 months after the survey, and a final release 2 years after the survey. JPL manages the project for UCLA PI Ned Wright, and conducts mission operations. Education and Public Outreach is provided by UC Berkeley's Space Science Laboratory. WISE hardware is presently being integrated and tested, with launch scheduled in November 2009.

Design Evolution of the Wide Field Infrared Survey Telescope Using Astrophysics Focused Telescope Assets (WFIRST-AFTA) and Lessons Learned

Science.gov (United States)

Peabody, Hume L.; Peters, Carlton V.; Rodriguez-Ruiz, Juan E.; McDonald, Carson S.; Content, David A.; Jackson, Clifton E.

2015-01-01

The design of the Wide Field Infrared Survey Telescope using Astrophysics Focused Telescope Assets (WFIRST-AFTA) continues to evolve as each design cycle is analyzed. In 2012, two Hubble sized (2.4 m diameter) telescopes were donated to NASA from elsewhere in the Federal Government. NASA began investigating potential uses for these telescopes and identified WFIRST as a mission to benefit from these assets. With an updated, deeper, and sharper field of view than previous design iterations with a smaller telescope, the optical designs of the WFIRST instruments were updated and the mechanical and thermal designs evolved around the new optical layout. Beginning with Design Cycle 3, significant analysis efforts yielded a design and model that could be evaluated for Structural-Thermal-Optical-Performance (STOP) purposes for the Wide Field Imager (WFI) and provided the basis for evaluating the high level observatory requirements. Development of the Cycle 3 thermal model provided some valuable analysis lessons learned and established best practices for future design cycles. However, the Cycle 3 design did include some major liens and evolving requirements which were addressed in the Cycle 4 Design. Some of the design changes are driven by requirements changes, while others are optimizations or solutions to liens from previous cycles. Again in Cycle 4, STOP analysis was performed and further insights into the overall design were gained leading to the Cycle 5 design effort currently underway. This paper seeks to capture the thermal design evolution, with focus on major design drivers, key decisions and their rationale, and lessons learned as the design evolved.

The Two-Dimensional Gabor Function Adapted to Natural Image Statistics: A Model of Simple-Cell Receptive Fields and Sparse Structure in Images.

Science.gov (United States)

Loxley, P N

2017-10-01

The two-dimensional Gabor function is adapted to natural image statistics, leading to a tractable probabilistic generative model that can be used to model simple cell receptive field profiles, or generate basis functions for sparse coding applications. Learning is found to be most pronounced in three Gabor function parameters representing the size and spatial frequency of the two-dimensional Gabor function and characterized by a nonuniform probability distribution with heavy tails. All three parameters are found to be strongly correlated, resulting in a basis of multiscale Gabor functions with similar aspect ratios and size-dependent spatial frequencies. A key finding is that the distribution of receptive-field sizes is scale invariant over a wide range of values, so there is no characteristic receptive field size selected by natural image statistics. The Gabor function aspect ratio is found to be approximately conserved by the learning rules and is therefore not well determined by natural image statistics. This allows for three distinct solutions: a basis of Gabor functions with sharp orientation resolution at the expense of spatial-frequency resolution, a basis of Gabor functions with sharp spatial-frequency resolution at the expense of orientation resolution, or a basis with unit aspect ratio. Arbitrary mixtures of all three cases are also possible. Two parameters controlling the shape of the marginal distributions in a probabilistic generative model fully account for all three solutions. The best-performing probabilistic generative model for sparse coding applications is found to be a gaussian copula with Pareto marginal probability density functions.

Usefulness of a Small-Field Digital Mammographic Imaging System Using Parabolic Polycapillary Optics as a Diagnostic Imaging Tool: a Preliminary Study

International Nuclear Information System (INIS)

Chon, Kwon Su; Park, Jeong Gon; Son, Hyun Hwa; Kang, Sung Hoon; Park, Seong Hoon; Kim, Hye Won; Kim, Hun Soo; Yoon, Kwon Ha

2009-01-01

To evaluate the efficacy for spatial resolution and radiation dose of a small-field digital mammographic imaging system using parabolic polycapillary optics. We developed a small-field digital mammographic imaging system composed of a CCD (charge coupled device) detector and an Xray source coupled with parabolic polycapillary optics. The spatial resolution and radiation dose according to various filters were evaluated for a small-field digital mammographic imaging system. The images of a test standard phantom and breast cancer tissue sample were obtained. The small-field digital mammographic imaging system had spatial resolutions of 12 lp/mm with molybdenum and rhodium filters with a 25-μm thickness. With a thicker molybdenum filter (100 μm thick), the system had a higher spatial resolution of 11 lp/mm and contrast of 0.48. The radiation dose for a rhodium filter with a 25-μm thickness was 0.13 mGy within a 10-mm-diameter local field. A larger field image greater than 10 mm in diameter could be obtained by scanning an object. On the small-field mammographic imaging system, microcalcifications of breast cancer tissue were clearly observed. A small-field digital mammographic imaging system with parabolic polycapillary optics may be a useful diagnostic tool for providing high-resolution imaging with a low radiation dose for examination of local volumes of breast tissue

Usefulness of a Small-Field Digital Mammographic Imaging System Using Parabolic Polycapillary Optics as a Diagnostic Imaging Tool: a Preliminary Study

Energy Technology Data Exchange (ETDEWEB)

Chon, Kwon Su [Catholic University of Daegu, Daegu (Korea, Republic of); Park, Jeong Gon; Son, Hyun Hwa; Kang, Sung Hoon; Park, Seong Hoon; Kim, Hye Won; Kim, Hun Soo; Yoon, Kwon Ha [Wonkwang University, Iksan (Korea, Republic of)

2009-12-15

To evaluate the efficacy for spatial resolution and radiation dose of a small-field digital mammographic imaging system using parabolic polycapillary optics. We developed a small-field digital mammographic imaging system composed of a CCD (charge coupled device) detector and an Xray source coupled with parabolic polycapillary optics. The spatial resolution and radiation dose according to various filters were evaluated for a small-field digital mammographic imaging system. The images of a test standard phantom and breast cancer tissue sample were obtained. The small-field digital mammographic imaging system had spatial resolutions of 12 lp/mm with molybdenum and rhodium filters with a 25-{mu}m thickness. With a thicker molybdenum filter (100 {mu}m thick), the system had a higher spatial resolution of 11 lp/mm and contrast of 0.48. The radiation dose for a rhodium filter with a 25-{mu}m thickness was 0.13 mGy within a 10-mm-diameter local field. A larger field image greater than 10 mm in diameter could be obtained by scanning an object. On the small-field mammographic imaging system, microcalcifications of breast cancer tissue were clearly observed. A small-field digital mammographic imaging system with parabolic polycapillary optics may be a useful diagnostic tool for providing high-resolution imaging with a low radiation dose for examination of local volumes of breast tissue.

Multistage morphological segmentation of bright-field and fluorescent microscopy images

Science.gov (United States)

Korzyńska, A.; Iwanowski, M.

2012-06-01

This paper describes the multistage morphological segmentation method (MSMA) for microscopic cell images. The proposed method enables us to study the cell behaviour by using a sequence of two types of microscopic images: bright field images and/or fluorescent images. The proposed method is based on two types of information: the cell texture coming from the bright field images and intensity of light emission, done by fluorescent markers. The method is dedicated to the image sequences segmentation and it is based on mathematical morphology methods supported by other image processing techniques. The method allows for detecting cells in image independently from a degree of their flattening and from presenting structures which produce the texture. It makes use of some synergic information from the fluorescent light emission image as the support information. The MSMA method has been applied to images acquired during the experiments on neural stem cells as well as to artificial images. In order to validate the method, two types of errors have been considered: the error of cell area detection and the error of cell position using artificial images as the "gold standard".

SQUID-detected magnetic resonance imaging in microtesla magnetic fields

International Nuclear Information System (INIS)

McDermott, Robert; Kelso, Nathan; Lee, SeungKyun; Moessle, Michael; Mueck, Michael; Myers, Whittier; Haken, Bernard ten; Seton, H.C.; Trabesinger, Andreas H.; Pines, Alex; Clarke, John

2003-01-01

We describe studies of nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI) of liquid samples at room temperature in microtesla magnetic fields. The nuclear spins are prepolarized in a strong transient field. The magnetic signals generated by the precessing spins, which range in frequency from tens of Hz to several kHz, are detected by a low-transition temperature dc SQUID (Superconducting QUantum Interference Device) coupled to an untuned, superconducting flux transformer configured as an axial gradiometer. The combination of prepolarization and frequency-independent detector sensitivity results in a high signal-to-noise ratio and high spectral resolution (∼1 Hz) even in grossly inhomogeneous magnetic fields. In the NMR experiments, the high spectral resolution enables us to detect the 10-Hz splitting of the spectrum of protons due to their scalar coupling to a 31P nucleus. Furthermore, the broadband detection scheme combined with a non-resonant field-reversal spin echo allows the simultaneous observation of signals from protons and 31P nuclei, even though their NMR resonance frequencies differ by a factor of 2.5. We extend our methodology to MRI in microtesla fields, where the high spectral resolution translates into high spatial resolution. We demonstrate two-dimensional images of a mineral oil phantom and slices of peppers, with a spatial resolution of about 1 mm. We also image an intact pepper using slice selection, again with 1-mm resolution. In further experiments we demonstrate T1-contrast imaging of a water phantom, some parts of which were doped with a paramagnetic salt to reduce the longitudinal relaxation time T1. Possible applications of this MRI technique include screening for tumors and integration with existing multichannel SQUID systems for brain imaging

Non-invasive terahertz field imaging inside parallel plate waveguides

DEFF Research Database (Denmark)

Iwaszczuk, Krzysztof; Andryieuski, Andrei; Lavrinenko, Andrei

2011-01-01

We present a non-invasive broadband air photonic method of imaging of the electric field of THz pulses propagating inside a tapered parallel plate waveguide. The method is based on field-enhanced second harmonic generation of the fundamental laser beam in an external electric field. We apply...

Imaging using long range dipolar field effects

International Nuclear Information System (INIS)

Gutteridge, Sarah

2002-01-01

The work in this thesis has been undertaken by the author, except where indicated in reference, within the Magnetic Resonance Centre, at the University of Nottingham during the period from October 1998 to March 2001. This thesis details the different characteristics of the long range dipolar field and its application to magnetic resonance imaging. The long range dipolar field is usually neglected in nuclear magnetic resonance experiments, as molecular tumbling decouples its effect at short distances. However, in highly polarised samples residual long range components have a significant effect on the evolution of the magnetisation, giving rise to multiple spin echoes and unexpected quantum coherences. Three applications utilising these dipolar field effects are documented in this thesis. The first demonstrates the spatial sensitivity of the signal generated via dipolar field effects in structured liquid state samples. The second utilises the signal produced by the dipolar field to create proton spin density maps. These maps directly yield an absolute value for the water content of the sample that is unaffected by relaxation and any RF inhomogeneity or calibration errors in the radio frequency pulses applied. It has also been suggested that the signal generated by dipolar field effects may provide novel contrast in functional magnetic resonance imaging. In the third application, the effects of microscopic susceptibility variation on the signal are studied and the relaxation rate of the signal is compared to that of a conventional spin echo. (author)

Ideal flood field images for SPECT uniformity correction

International Nuclear Information System (INIS)

Oppenheim, B.E.; Appledorn, C.R.

1984-01-01

Since as little as 2.5% camera non-uniformity can cause disturbing artifacts in SPECT imaging, the ideal flood field images for uniformity correction would be made with the collimator in place using a perfectly uniform sheet source. While such a source is not realizable the equivalent images can be generated by mapping the activity distribution of a Co-57 sheet source and correcting subsequent images of the source with this mapping. Mapping is accomplished by analyzing equal-time images of the source made in multiple precisely determined positions. The ratio of counts detected in the same region of two images is a measure of the ratio of the activities of the two portions of the source imaged in that region. The activity distribution in the sheet source is determined from a set of such ratios. The more source positions imaged in a given time, the more accurate the source mapping, according to results of a computer simulation. A 1.9 mCi Co-57 sheet source was shifted by 12 mm increments along the horizontal and vertical axis of the camera face to 9 positions on each axis. The source was imaged for 20 min in each position and 214 million total counts were accumulated. The activity distribution of the source, relative to the center pixel, was determined for a 31 x 31 array. The integral uniformity was found to be 2.8%. The RMS error for such a mapping was determined by computer simulation to be 0.46%. The activity distribution was used to correct a high count flood field image for non-uniformities attributable to the Co-57 source. Such a corrected image represents camera plus collimator response to an almost perfectly uniform sheet source

Image reconstruction in k-space from MR data encoded with ambiguous gradient fields.

Science.gov (United States)

Schultz, Gerrit; Gallichan, Daniel; Weber, Hans; Witschey, Walter R T; Honal, Matthias; Hennig, Jürgen; Zaitsev, Maxim

2015-02-01

In this work, the limits of image reconstruction in k-space are explored when non-bijective gradient fields are used for spatial encoding. The image space analogy between parallel imaging and imaging with non-bijective encoding fields is partially broken in k-space. As a consequence, it is hypothesized and proven that ambiguities can only be resolved partially in k-space, and not completely as is the case in image space. Image-space and k-space based reconstruction algorithms for multi-channel radiofrequency data acquisitions are programmed and tested using numerical simulations as well as in vivo measurement data. The hypothesis is verified based on an analysis of reconstructed images. It is found that non-bijective gradient fields have the effect that densely sampled autocalibration data, used for k-space reconstruction, provide less information than a separate scan of the receiver coil sensitivity maps, used for image space reconstruction. Consequently, in k-space only the undersampling artifact can be unfolded, whereas in image space, it is also possible to resolve aliasing that is caused by the non-bijectivity of the gradient fields. For standard imaging, reconstruction in image space and in k-space is nearly equivalent, whereas there is a fundamental difference with practical consequences for the selection of image reconstruction algorithms when non-bijective encoding fields are involved. © 2014 Wiley Periodicals, Inc.

Construction of imaging system for wide-field-range ESR spectra using localized microwave field and its case study of crystal orientation in suspension of copper sulfate pentahydrate (CuSO4.5H2O)

International Nuclear Information System (INIS)

Tani, Atsushi; Ueno, Takehiro; Yamanaka, Chihiro; Katsura, Makoto; Ikeya, Motoji

2005-01-01

A scanning electron spin resonance (ESR) microscope using a localized microwave field was redesigned to measure ESR spectra from 0 to 400mT using electromagnets. Divalent copper ion (Cu 2+ ) in copper sulfate pentahydrate (CuSO 4 .5H 2 O) was imaged, after the powdered samples were cemented in silicone rubber under a magnetic field. The ratio of the two signal intensities at g=2.27 and 2.08 clearly indicates the orientation of the particles. This method can be used for mapping the local magnetic field and its direction

Construction of imaging system for wide-field-range ESR spectra using localized microwave field and its case study of crystal orientation in suspension of copper sulfate pentahydrate (CuSO4 . 5H2O).

Science.gov (United States)

Tani, Atsushi; Ueno, Takehiro; Yamanaka, Chihiro; Katsura, Makoto; Ikeya, Motoji

2005-02-01

A scanning electron spin resonance (ESR) microscope using a localized microwave field was redesigned to measure ESR spectra from 0 to 400 mT using electromagnets. Divalent copper ion (Cu2+) in copper sulfate pentahydrate (CuSO4 . 5H2O) was imaged, after the powdered samples were cemented in silicone rubber under a magnetic field. The ratio of the two signal intensities at g=2.27 and 2.08 clearly indicates the orientation of the particles. This method can be used for mapping the local magnetic field and its direction.

Self-diffusion imaging by spin echo in Earth's magnetic field.

Science.gov (United States)

Mohoric, A; Stepisnik, J; Kos, M; Planinsi

1999-01-01

The NMR of the Earth's magnetic field is used for diffusion-weighted imaging of phantoms. Due to a weak Larmor field, care needs to be taken regarding the use of the usual high field assumption in calculating the effect of the applied inhomogeneous magnetic field. The usual definition of the magnetic field gradient must be replaced by a generalized formula valid when the strength of a nonuniform magnetic field and a Larmor field are comparable (J. Stepisnik, Z. Phys. Chem. 190, 51-62 (1995)). It turns out that the expression for spin echo attenuation is identical to the well-known Torrey formula only when the applied nonuniform field has a proper symmetry. This kind of problem may occur in a strong Larmor field as well as when the slow diffusion rate of particles needs an extremely strong gradient to be applied. The measurements of the geomagnetic field NMR demonstrate the usefulness of the method for diffusion and flow-weighted imaging. Copyright 1999 Academic Press.

Imaging process in field ion microscopy from the FEM to the atom-probe

International Nuclear Information System (INIS)

Mueller, E.W.

1976-01-01

The development of the technique and the interpretations of the imaging mechanism, which involve a number of complex phenomena, are traced from the invention of the field emission microscope and the discovery of field desorption to the first field ion microscope. Subsequent introduction of cryogenic operation and utilization of field evaporation led, prior to 1960, to the attainment of high-quality images with full resolution of the atomic lattice and to fundamental applications in the study of lattice defects and other phenomena of physical metallurgy. Extension to the lower-melting metals by imaging with neon was aided by the availability of image intensification technology. The invention of the atom-probe FIM in 1967, permitting surface analysis with ultimate single-atom sensitivity, also brought the discovery of unexpected effects, such as field adsorption of the noble images gases and the abundant formation of metal-noble gas molecular ions. These phenomena, together with recent results of field desorption microcopy, must be included in a refined interpretation of the imaging process. 16 figs., 115 references

Extended depth of field imaging through multicore optical fibers.

Science.gov (United States)

Orth, Antony; Ploschner, Martin; Maksymov, Ivan S; Gibson, Brant C

2018-03-05

Compact microendoscopes use multicore optical fibers (MOFs) to visualize hard-to-reach regions of the body. These devices typically have a large numerical aperture (NA) and are fixed-focus, leading to blurry images from a shallow depth of field with little focus control. In this work, we demonstrate a method to digitally adjust the collection aperture and therefore extend the depth of field of lensless MOF imaging probes. We show that the depth of field can be more than doubled for certain spatial frequencies, and observe a resolution enhancement of up to 78% at a distance of 50μm from the MOF facet. Our technique enables imaging of complex 3D objects at a comparable working distance to lensed MOFs, but without the requirement of lenses, scan units or transmission matrix calibration. Our approach is implemented in post processing and may be used to improve contrast in any microendoscopic probe utilizing a MOF and incoherent light.

The research of Digital Holographic Object Wave Field Reconstruction in Image and Object Space

Institute of Scientific and Technical Information of China (English)

LI Jun-Chang; PENG Zu-Jie; FU Yun-Chang

2011-01-01

@@ For conveniently detecting objects of different sizes using digital holography, usual measurements employ the object wave transformed by an optical system with different magnifications to fit charge coupled devices (CCDs), then the object field reconstruction involves the diffraction calculation of the optic wave passing through the optical system.We propose two methods to reconstruct the object field.The one is that, when the object is imaging in an image space in which we reconstruct the image of the object field, the object field can be expressed according to the object-image relationship.The other is that, when the object field reaching CCD is imaged in an object space in which we reconstruct the object field, the optical system is described by introducing matrix optics in this paper.The reconstruction formulae which easily use classic diffraction integral are derived.Finally, experimental verifications are also accomplished.%For conveniently detecting objects of different sizes using digital holography, usual measurements employ the object wave transformed by an optical system with different magnifications to fit charge coupled devices (CCDs), then the object Reid reconstruction involves the diffraction calculation of the optic wave passing through the optical system. We propose two methods to reconstruct the object field. The one is that, when the object is imaging in an image space in which we reconstruct the image of the object field, the object field can be expressed according to the object-image relationship. The other is that, when the object field reaching CCD is imaged in an object space in which we reconstruct the object field, the optical system is described by introducing matrix optics in this paper. The reconstruction formulae which easily use classic diffraction integral are derived. Finally, experimental verifications are also accomplished.

High resolution NMR imaging using a high field yokeless permanent magnet.

Science.gov (United States)

Kose, Katsumi; Haishi, Tomoyuki

2011-01-01

We measured the homogeneity and stability of the magnetic field of a high field (about 1.04 tesla) yokeless permanent magnet with 40-mm gap for high resolution nuclear magnetic resonance (NMR) imaging. Homogeneity was evaluated using a 3-dimensional (3D) lattice phantom and 3D spin-echo imaging sequences. In the central sphere (20-mm diameter), peak-to-peak magnetic field inhomogeneity was about 60 ppm, and the root-mean-square was 8 ppm. We measured room temperature, magnet temperature, and NMR frequency of the magnet simultaneously every minute for about 68 hours with and without the thermal insulator of the magnet. A simple mathematical model described the magnet's thermal property. Based on magnet performance, we performed high resolution (up to [20 µm](2)) imaging with internal NMR lock sequences of several biological samples. Our results demonstrated the usefulness of the high field small yokeless permanent magnet for high resolution NMR imaging.

High resolution NMR imaging using a high field yokeless permanent magnet

International Nuclear Information System (INIS)

Kose, Katsumi; Haishi, Tomoyuki

2011-01-01

We measured the homogeneity and stability of the magnetic field of a high field (about 1.04 tesla) yokeless permanent magnet with 40-mm gap for high resolution nuclear magnetic resonance (NMR) imaging. Homogeneity was evaluated using a 3-dimensional (3D) lattice phantom and 3D spin-echo imaging sequences. In the central sphere (20-mm diameter), peak-to-peak magnetic field inhomogeneity was about 60 ppm, and the root-mean-square was 8 ppm. We measured room temperature, magnet temperature, and NMR frequency of the magnet simultaneously every minute for about 68 hours with and without the thermal insulator of the magnet. A simple mathematical model described the magnet's thermal property. Based on magnet performance, we performed high resolution (up to [20 μm] 2 ) imaging with internal NMR lock sequences of several biological samples. Our results demonstrated the usefulness of the high field small yokeless permanent magnet for high resolution NMR imaging. (author)

Simulations of multi-contrast x-ray imaging using near-field speckles

Energy Technology Data Exchange (ETDEWEB)

Zdora, Marie-Christine [Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, 85748 Garching (Germany); Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom and Department of Physics & Astronomy, University College London, London, WC1E 6BT (United Kingdom); Thibault, Pierre [Department of Physics & Astronomy, University College London, London, WC1E 6BT (United Kingdom); Herzen, Julia; Pfeiffer, Franz [Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, 85748 Garching (Germany); Zanette, Irene [Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE (United Kingdom); Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, 85748 Garching (Germany)

2016-01-28

X-ray dark-field and phase-contrast imaging using near-field speckles is a novel technique that overcomes limitations inherent in conventional absorption x-ray imaging, i.e. poor contrast for features with similar density. Speckle-based imaging yields a wealth of information with a simple setup tolerant to polychromatic and divergent beams, and simple data acquisition and analysis procedures. Here, we present a simulation software used to model the image formation with the speckle-based technique, and we compare simulated results on a phantom sample with experimental synchrotron data. Thorough simulation of a speckle-based imaging experiment will help for better understanding and optimising the technique itself.

A sea-land segmentation algorithm based on multi-feature fusion for a large-field remote sensing image

Science.gov (United States)

Li, Jing; Xie, Weixin; Pei, Jihong

2018-03-01

Sea-land segmentation is one of the key technologies of sea target detection in remote sensing images. At present, the existing algorithms have the problems of low accuracy, low universality and poor automatic performance. This paper puts forward a sea-land segmentation algorithm based on multi-feature fusion for a large-field remote sensing image removing island. Firstly, the coastline data is extracted and all of land area is labeled by using the geographic information in large-field remote sensing image. Secondly, three features (local entropy, local texture and local gradient mean) is extracted in the sea-land border area, and the three features combine a 3D feature vector. And then the MultiGaussian model is adopted to describe 3D feature vectors of sea background in the edge of the coastline. Based on this multi-gaussian sea background model, the sea pixels and land pixels near coastline are classified more precise. Finally, the coarse segmentation result and the fine segmentation result are fused to obtain the accurate sea-land segmentation. Comparing and analyzing the experimental results by subjective vision, it shows that the proposed method has high segmentation accuracy, wide applicability and strong anti-disturbance ability.

Dynamic Raman imaging system with high spatial and temporal resolution

Science.gov (United States)

Wang, Lei; Dai, Yinzhen; He, Hao; Lv, Ruiqi; Zong, Cheng; Ren, Bin

2017-09-01

There is an increasing need to study dynamic changing systems with significantly high spatial and temporal resolutions. In this work, we integrated point-scanning, line-scanning, and wide-field Raman imaging techniques into a single system. By using an Electron Multiplying CCD (EMCCD) with a high gain and high frame rate, we significantly reduced the time required for wide-field imaging, making it possible to monitor the electrochemical reactions in situ. The highest frame rate of EMCDD was ˜50 fps, and the Raman images for a specific Raman peak can be obtained by passing the signal from the sample through the Liquid Crystal Tunable Filter. The spatial resolutions of scanning imaging and wide-field imaging with a 100× objective (NA = 0.9) are 0.5 × 0.5 μm2 and 0.36 × 0.36 μm2, respectively. The system was used to study the surface plasmon resonance of Au nanorods, the surface-enhanced Raman scattering signal distribution for Au Nanoparticle aggregates, and dynamic Raman imaging of an electrochemical reacting system.

Excessive current in wide superconducting films

International Nuclear Information System (INIS)

Volotskaya, V.G.; Sivakov, A.G.; Turutanov, O.G.

1986-01-01

The resistive state of a wide long film due to superconductivity destruction by current is studied. The voltage-independent excess current I 0 is observed on I-V curves at high transport currents. The two-dimensional image of the current-carrying sample obtained by laser scanning technique in this current range indicates that the whole film is in the resistive state. The current I 0 is measured as a function of magnetic field and SHF power

Electric Potential and Electric Field Imaging with Dynamic Applications & Extensions

Science.gov (United States)

Generazio, Ed

2017-01-01

The technology and methods for remote quantitative imaging of electrostatic potentials and electrostatic fields in and around objects and in free space is presented. Electric field imaging (EFI) technology may be applied to characterize intrinsic or existing electric potentials and electric fields, or an externally generated electrostatic field made be used for volumes to be inspected with EFI. The baseline sensor technology (e-Sensor) and its construction, optional electric field generation (quasi-static generator), and current e- Sensor enhancements (ephemeral e-Sensor) are discussed. Critical design elements of current linear and real-time two-dimensional (2D) measurement systems are highlighted, and the development of a three dimensional (3D) EFI system is presented. Demonstrations for structural, electronic, human, and memory applications are shown. Recent work demonstrates that phonons may be used to create and annihilate electric dipoles within structures. Phonon induced dipoles are ephemeral and their polarization, strength, and location may be quantitatively characterized by EFI providing a new subsurface Phonon-EFI imaging technology. Results from real-time imaging of combustion and ion flow, and their measurement complications, will be discussed. Extensions to environment, Space and subterranean applications will be presented, and initial results for quantitative characterizing material properties are shown. A wearable EFI system has been developed by using fundamental EFI concepts. These new EFI capabilities are demonstrated to characterize electric charge distribution creating a new field of study embracing areas of interest including electrostatic discharge (ESD) mitigation, manufacturing quality control, crime scene forensics, design and materials selection for advanced sensors, combustion science, on-orbit space potential, container inspection, remote characterization of electronic circuits and level of activation, dielectric morphology of

Superresolution Near-field Imaging with Surface Waves

KAUST Repository

Fu, Lei; Liu, Zhaolun; Schuster, Gerard T.

2017-01-01

We present the theory for near-field superresolution imaging with surface waves and time reverse mirrors (TRMs). Theoretical formulas and numerical results show that applying the TRM operation to surface waves in an elastic half-space can achieve

Dosimetric impact of image artifact from a wide-bore CT scanner in radiotherapy treatment planning

Energy Technology Data Exchange (ETDEWEB)

Wu, Vincent; Podgorsak, Matthew B.; Tran, Tuan-Anh; Malhotra, Harish K.; Wang, Iris Z. [Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263 (United States); Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263 and Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214 (United States); Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263 (United States); Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263 and Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214 (United States)

2011-07-15

Purpose: Traditional computed tomography (CT) units provide a maximum scan field-of-view (sFOV) diameter of 50 cm and a limited bore size, which cannot accommodate a large patient habitus or an extended simulation setup in radiation therapy (RT). Wide-bore CT scanners with increased bore size were developed to address these needs. Some scanners have the capacity to reconstruct the CT images at an extended FOV (eFOV), through data interpolation or extrapolation, using projection data acquired with a conventional sFOV. Objects that extend past the sFOV for eFOV reconstruction may generate image artifacts resulting from truncated projection data; this may distort CT numbers and structure contours in the region beyond the sFOV. The purpose of this study was to evaluate the dosimetric impact of image artifacts from eFOV reconstruction with a wide-bore CT scanner in radiotherapy (RT) treatment planning. Methods: Testing phantoms (i.e., a mini CT phantom with equivalent tissue inserts, a set of CT normal phantoms and anthropomorphic phantoms of the thorax and the pelvis) were used to evaluate eFOV artifacts. Reference baseline images of these phantoms were acquired with the phantom centrally positioned within the sFOV. For comparison, the phantoms were then shifted laterally and scanned partially outside the sFOV, but still within the eFOV. Treatment plans were generated for the thoracic and pelvic anthropomorphic phantoms utilizing the Eclipse treatment planning system (TPS) to study the potential effects of eFOV artifacts on dose calculations. All dose calculations of baseline and test treatment plans were carried out using the same MU. Results: Results show that both body contour and CT numbers are altered by image artifacts in eFOV reconstruction. CT number distortions of up to -356 HU for bone tissue and up to 323 HU for lung tissue were observed in the mini CT phantom. Results from the large body normal phantom, which is close to a clinical patient size, show

Surface impedance of superconductors in wide frequency ranges for wake field calculations

International Nuclear Information System (INIS)

Davidovskii, V.G.

2006-01-01

The problem of the surface impedance of superconductors in wide frequency ranges for calculations of wake fields, generated by bunches of charged particles moving axially inside a metallic vacuum chambers, is solved. The case of specular electron reflection at the superconductor surface is considered. The expression for the surface impedance of superconductors suitable for numerical computation is derived [ru

Wide-Field Infrared Survey Explorer Observations of the Evolution of Massive Star-Forming Regions

Science.gov (United States)

Koenig, X. P.; Leisawitz, D. T.; Benford, D. J.; Rebull, L. M.; Padgett, D. L.; Asslef, R. J.

2012-01-01

We present the results of a mid-infrared survey of II outer Galaxy massive star-forming regions and 3 open clusters with data from the Wide-field Infrared Survey Explorer (WISE). Using a newly developed photometric scheme to identify young stellar objects and exclude extragalactic contamination, we have studied the distribution of young stars within each region. These data tend to support the hypothesis that latter generations may be triggered by the interaction of winds and radiation from the first burst of massive star formation with the molecular cloud material leftover from that earlier generation of stars. We dub this process the "fireworks hypothesis" since star formation by this mechanism would proceed rapidly and resemble a burst of fireworks. We have also analyzed small cutout WISE images of the structures around the edges of these massive star-forming regions. We observe large (1-3 pc size) pillar and trunk-like structures of diffuse emission nebulosity tracing excited polycyclic aromatic hydrocarbon molecules and small dust grains at the perimeter of the massive star-forming regions. These structures contain small clusters of emerging Class I and Class II sources, but some are forming only a single to a few new stars.

WIDE-FIELD INFRARED SURVEY EXPLORER OBSERVATIONS OF THE EVOLUTION OF MASSIVE STAR-FORMING REGIONS

International Nuclear Information System (INIS)

Koenig, X. P.; Leisawitz, D. T.; Benford, D. J.; Padgett, D. L.; Rebull, L. M.; Assef, R. J.

2012-01-01

We present the results of a mid-infrared survey of 11 outer Galaxy massive star-forming regions and 3 open clusters with data from the Wide-field Infrared Survey Explorer (WISE). Using a newly developed photometric scheme to identify young stellar objects and exclude extragalactic contamination, we have studied the distribution of young stars within each region. These data tend to support the hypothesis that latter generations may be triggered by the interaction of winds and radiation from the first burst of massive star formation with the molecular cloud material leftover from that earlier generation of stars. We dub this process the 'fireworks hypothesis' since star formation by this mechanism would proceed rapidly and resemble a burst of fireworks. We have also analyzed small cutout WISE images of the structures around the edges of these massive star-forming regions. We observe large (1-3 pc size) pillar and trunk-like structures of diffuse emission nebulosity tracing excited polycyclic aromatic hydrocarbon molecules and small dust grains at the perimeter of the massive star-forming regions. These structures contain small clusters of emerging Class I and Class II sources, but some are forming only a single to a few new stars.

A laboratory 8 keV transmission full-field x-ray microscope with a polycapillary as condenser for bright and dark field imaging

Energy Technology Data Exchange (ETDEWEB)

Baumbach, S., E-mail: baumbach@rheinahrcampus.de; Wilhein, T. [Institute for X-Optics, University of Applied Sciences Koblenz, RheinAhrCampus Remagen, Joseph-Rovan-Allee 2, D-53424 Remagen (Germany); Kanngießer, B.; Malzer, W. [Institute for Optics and Atomic Physics, Technical University of Berlin, Hardenbergstrasse 36, D-10623 Berlin (Germany); Stiel, H. [Max-Born-Institute, Max-Born-Strasse 2A, D-12489 Berlin (Germany)

2015-08-15

This article introduces a laboratory setup of a transmission full-field x-ray microscope at 8 keV photon energy. The microscope operates in bright and dark field imaging mode with a maximum field of view of 50 μm. Since the illumination geometry determines whether the sample is illuminated homogeneously and moreover, if different imaging methods can be applied, the condenser optic is one of the most significant parts. With a new type of x-ray condenser, a polycapillary optic, we realized bright field imaging and for the first time dark field imaging at 8 keV photon energy in a laboratory setup. A detector limited spatial resolution of 210 nm is measured on x-ray images of Siemens star test patterns.

Direct imaging of neural currents using ultra-low field magnetic resonance techniques

Science.gov (United States)

Volegov, Petr L [Los Alamos, NM; Matlashov, Andrei N [Los Alamos, NM; Mosher, John C [Los Alamos, NM; Espy, Michelle A [Los Alamos, NM; Kraus, Jr., Robert H.

2009-08-11

Using resonant interactions to directly and tomographically image neural activity in the human brain using magnetic resonance imaging (MRI) techniques at ultra-low field (ULF), the present inventors have established an approach that is sensitive to magnetic field distributions local to the spin population in cortex at the Larmor frequency of the measurement field. Because the Larmor frequency can be readily manipulated (through varying B.sub.m), one can also envision using ULF-DNI to image the frequency distribution of the local fields in cortex. Such information, taken together with simultaneous acquisition of MEG and ULF-NMR signals, enables non-invasive exploration of the correlation between local fields induced by neural activity in cortex and more `distant` measures of brain activity such as MEG and EEG.

The design of the wide field monitor for LOFT

DEFF Research Database (Denmark)

Brandt, Søren; Hernanz, M.; Alvarez, L.

2014-01-01

is designed to carry on-board two instruments with sensitivity in the 2-50 keV range: a 10 m 2 class Large Area Detector (LAD) with a monitor (WFM) making use of coded masks and providing an instantaneous coverage of more than 1/3 of the sky. The prime goal of the WFM...... will be to detect transient sources to be observed by the LAD. However, thanks to its unique combination of a wide field of view (FoV) and energy resolution (better than 500 eV), the WFM will be also an excellent monitoring instrument to study the long term variability of many classes of X-ray sources. The WFM...

Microscopy refocusing and dark-field imaging by using a simple LED array

OpenAIRE

Zheng, Guoan; Kolner, Christopher; Yang, Changhuei

2011-01-01

The condenser is one of the main components in most transmitted light compound microscopes. In this Letter, we show that such a condenser can be replaced by a programmable LED array to achieve greater imaging flexibility and functionality. Without mechanically scanning the sample or changing the microscope setup, the proposed approach can be used for dark-field imaging, bright-field imaging, microscopy sectioning, and digital refocusing. Images of a starfish embryo were acquired by using such...

Coupled-spin filtered MR imaging in a low field

International Nuclear Information System (INIS)

Baudouin, C.J.; Bryant, D.J.; Coutts, G.A.; Bydder, G.M.; Young, I.R.

1990-01-01

This paper investigates the use of an editing method of imaging using spin-echo sequences with differing radio-frequency (RF) pulses for lipid imaging in poor fields and to compare it with solvent-suppression methods. A technique of echo difference imaging (EDI) has been described in which two data sets are acquired: a normal spin-echo sequence (90-180) and a 90-90 spin-echo sequence. The intrinsic signal of uncoupled spins in the EDI method is one-half that of the conventional sequence, so that subtracting twice the EDI signal from the conventional signal should result in signal cancellation. With coupled spins, the application of the second 90 degrees pulse results in coherence transfer, and echo magnitude will not be one-half that of the 90-180 echo. This method of lipid imaging may be less vulnerable to field inhomogeneity than are solvent-suppression methods. Phantom and in vivo studies were performed at 0.15 T (TE = 44 msec and various TRs)

Real-time Image Generation for Compressive Light Field Displays

International Nuclear Information System (INIS)

Wetzstein, G; Lanman, D; Hirsch, M; Raskar, R

2013-01-01

With the invention of integral imaging and parallax barriers in the beginning of the 20th century, glasses-free 3D displays have become feasible. Only today—more than a century later—glasses-free 3D displays are finally emerging in the consumer market. The technologies being employed in current-generation devices, however, are fundamentally the same as what was invented 100 years ago. With rapid advances in optical fabrication, digital processing power, and computational perception, a new generation of display technology is emerging: compressive displays exploring the co-design of optical elements and computational processing while taking particular characteristics of the human visual system into account. In this paper, we discuss real-time implementation strategies for emerging compressive light field displays. We consider displays composed of multiple stacked layers of light-attenuating or polarization-rotating layers, such as LCDs. The involved image generation requires iterative tomographic image synthesis. We demonstrate that, for the case of light field display, computed tomographic light field synthesis maps well to operations included in the standard graphics pipeline, facilitating efficient GPU-based implementations with real-time framerates.

Review of near-field optics and superlenses for sub-diffraction-limited nano-imaging

Directory of Open Access Journals (Sweden)

Wyatt Adams

2016-10-01

Full Text Available Near-field optics and superlenses for imaging beyond Abbe’s diffraction limit are reviewed. A comprehensive and contemporary background is given on scanning near-field microscopy and superlensing. Attention is brought to recent research leveraging scanning near-field optical microscopy with superlenses for new nano-imaging capabilities. Future research directions are explored for realizing the goal of low-cost and high-performance sub-diffraction-limited imaging systems.

Laser speckle contrast imaging using light field microscope approach

Science.gov (United States)

Ma, Xiaohui; Wang, Anting; Ma, Fenghua; Wang, Zi; Ming, Hai

2018-01-01

In this paper, a laser speckle contrast imaging (LSCI) system using light field (LF) microscope approach is proposed. As far as we known, it is first time to combine LSCI with LF. To verify this idea, a prototype consists of a modified LF microscope imaging system and an experimental device was built. A commercially used Lytro camera was modified for microscope imaging. Hollow glass tubes with different depth fixed in glass dish were used to simulate the vessels in brain and test the performance of the system. Compared with conventional LSCI, three new functions can be realized by using our system, which include refocusing, extending the depth of field (DOF) and gathering 3D information. Experiments show that the principle is feasible and the proposed system works well.

Preclinical evaluation of spatial frequency domain-enabled wide-field quantitative imaging for enhanced glioma resection

Science.gov (United States)

Sibai, Mira; Fisher, Carl; Veilleux, Israel; Elliott, Jonathan T.; Leblond, Frederic; Roberts, David W.; Wilson, Brian C.

2017-07-01

5-Aminolevelunic acid-induced protoporphyrin IX (PpIX) fluorescence-guided resection (FGR) enables maximum safe resection of glioma by providing real-time tumor contrast. However, the subjective visual assessment and the variable intrinsic optical attenuation of tissue limit this technique to reliably delineating only high-grade tumors that display strong fluorescence. We have previously shown, using a fiber-optic probe, that quantitative assessment using noninvasive point spectroscopic measurements of the absolute PpIX concentration in tissue further improves the accuracy of FGR, extending it to surgically curable low-grade glioma. More recently, we have shown that implementing spatial frequency domain imaging with a fluorescent-light transport model enables recovery of two-dimensional images of [PpIX], alleviating the need for time-consuming point sampling of the brain surface. We present first results of this technique modified for in vivo imaging on an RG2 rat brain tumor model. Despite the moderate errors in retrieving the absorption and reduced scattering coefficients in the subdiffusive regime of 14% and 19%, respectively, the recovered [PpIX] maps agree within 10% of the point [PpIX] values measured by the fiber-optic probe, validating its potential as an extension or an alternative to point sampling during glioma resection.

Homography Propagation and Optimization for Wide-Baseline Street Image Interpolation.

Science.gov (United States)

Nie, Yongwei; Zhang, Zhensong; Sun, Hanqiu; Su, Tan; Li, Guiqing

2017-10-01

Wide-baseline street image interpolation is useful but very challenging. Existing approaches either rely on heavyweight 3D reconstruction or computationally intensive deep networks. We present a lightweight and efficient method which uses simple homography computing and refining operators to estimate piecewise smooth homographies between input views. To achieve the goal, we show how to combine homography fitting and homography propagation together based on reliable and unreliable superpixel discrimination. Such a combination, other than using homography fitting only, dramatically increases the accuracy and robustness of the estimated homographies. Then, we integrate the concepts of homography and mesh warping, and propose a novel homography-constrained warping formulation which enforces smoothness between neighboring homographies by utilizing the first-order continuity of the warped mesh. This further eliminates small artifacts of overlapping, stretching, etc. The proposed method is lightweight and flexible, allows wide-baseline interpolation. It improves the state of the art and demonstrates that homography computation suffices for interpolation. Experiments on city and rural datasets validate the efficiency and effectiveness of our method.

Astronomical Orientation Method Based on Lunar Observations Utilizing Super Wide Field of View

Directory of Open Access Journals (Sweden)

PU Junyu

2018-04-01

Full Text Available In this paper,astronomical orientation is achieved by observing the moon utilizing camera with super wide field of view,and formulae are deduced in detail.An experiment based on real observations verified the stability of the method.In this experiment,after 15 minutes' tracking shoots,the internal precision could be superior to ±7.5" and the external precision could approximately reach ±20".This camera-based method for astronomical orientation can change the traditional mode (aiming by human eye based on theodolite,thus lowering the requirements for operator's skill to some extent.Furthermore,camera with super wide field of view can realize the function of continuous tracking shoots on the moon without complicated servo control devices.Considering the similar existence of gravity on the moon and the earth's phase change when observed from the moon,once the technology of self-leveling is developed,this method can be extended to orientation for lunar rover by shooting the earth.

Multimode simulations of a wide field of view double-Fourier far-infrared spatio-spectral interferometer

Science.gov (United States)

Bracken, Colm P.; Lightfoot, John; O'Sullivan, Creidhe; Murphy, J. Anthony; Donohoe, Anthony; Savini, Giorgio; Juanola-Parramon, Roser; The Fisica Consortium, On Behalf Of

2018-01-01

In the absence of 50-m class space-based observatories, subarcsecond astronomy spanning the full far-infrared wavelength range will require space-based long-baseline interferometry. The long baselines of up to tens of meters are necessary to achieve subarcsecond resolution demanded by science goals. Also, practical observing times command a field of view toward an arcminute (1‧) or so, not achievable with a single on-axis coherent detector. This paper is concerned with an application of an end-to-end instrument simulator PyFIInS, developed as part of the FISICA project under funding from the European Commission's seventh Framework Programme for Research and Technological Development (FP7). Predicted results of wide field of view spatio-spectral interferometry through simulations of a long-baseline, double-Fourier, far-infrared interferometer concept are presented and analyzed. It is shown how such an interferometer, illuminated by a multimode detector can recover a large field of view at subarcsecond angular resolution, resulting in similar image quality as that achieved by illuminating the system with an array of coherent detectors. Through careful analysis, the importance of accounting for the correct number of higher-order optical modes is demonstrated, as well as accounting for both orthogonal polarizations. Given that it is very difficult to manufacture waveguide and feed structures at sub-mm wavelengths, the larger multimode design is recommended over the array of smaller single mode detectors. A brief note is provided in the conclusion of this paper addressing a more elegant solution to modeling far-infrared interferometers, which holds promise for improving the computational efficiency of the simulations presented here.

Light-pollution measurement with the Wide-field all-sky image analyzing monitoring system

Science.gov (United States)

Vítek, S.

2017-07-01

The purpose of this experiment was to measure light pollution in the capital of Czech Republic, Prague. As a measuring instrument is used calibrated consumer level digital single reflex camera with IR cut filter, therefore, the paper reports results of measuring and monitoring of the light pollution in the wavelength range of 390 - 700 nm, which most affects visual range astronomy. Combining frames of different exposure times made with a digital camera coupled with fish-eye lens allow to create high dynamic range images, contain meaningful values, so such a system can provide absolute values of the sky brightness.

Far- and near-field second-harmonic imaging of ferroelectric domain walls

DEFF Research Database (Denmark)

Bozhevolnyi, Sergey I.; Pedersen, K.; Skettrup, Torben

1998-01-01

Domain walls in periodically poled ferroelectric LiNbO3 crystals are observed with both far- and near-field imaging techniques that make use of second harmonic generation in the transition regions between neighbouring domains. Second harmonic images of domain walls represent bright lines of about.......5 micrometers in width (as measured with the near-field microscope) for the polarization of the second harmonic radiation perpendicular to the domain walls. Origin and selection rules for the constrast in second harmonic images of domain walls are discussed....

A wide angle view imaging diagnostic with all reflective, in-vessel optics at JET

Energy Technology Data Exchange (ETDEWEB)

Clever, M. [Institute of Energy and Climate Research – Plasma Physics, Forschungszentrum Jülich GmbH, Association EURATOM-FZJ, 52425 Jülich (Germany); Arnoux, G.; Balshaw, N. [Euratom/CCFE Fusion Association, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Garcia-Sanchez, P. [Laboratorio Nacional de Fusion, Asociacion EURATOM-CIEMAT, Madrid (Spain); Patel, K. [Euratom/CCFE Fusion Association, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Sergienko, G. [Institute of Energy and Climate Research – Plasma Physics, Forschungszentrum Jülich GmbH, Association EURATOM-FZJ, 52425 Jülich (Germany); Soler, D. [Winlight System, 135 rue Benjamin Franklin, ZA Saint Martin, F-84120 Pertuis (France); Stamp, M.F.; Williams, J.; Zastrow, K.-D. [Euratom/CCFE Fusion Association, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom)

2013-10-15

Highlights: ► A new wide angle view camera system has been installed at JET. ► The system helps to protect the ITER-like wall plasma facing components from damage. ► The coverage of the vessel by camera observation systems was increased. ► The system comprises an in-vessel part with parabolic and flat mirrors. ► The required image quality for plasma monitoring and wall protection was delivered. -- Abstract: A new wide angle view camera system has been installed at JET in preparation for the ITER-like wall campaigns. It considerably increases the coverage of the vessel by camera observation systems and thereby helps to protect the – compared to carbon – more fragile plasma facing components from damage. The system comprises an in-vessel part with parabolic and flat mirrors and an ex-vessel part with beam splitters, lenses and cameras. The system delivered the image quality required for plasma monitoring and wall protection.

Fast processing of microscopic images using object-based extended depth of field.

Science.gov (United States)

Intarapanich, Apichart; Kaewkamnerd, Saowaluck; Pannarut, Montri; Shaw, Philip J; Tongsima, Sissades

2016-12-22

Microscopic analysis requires that foreground objects of interest, e.g. cells, are in focus. In a typical microscopic specimen, the foreground objects may lie on different depths of field necessitating capture of multiple images taken at different focal planes. The extended depth of field (EDoF) technique is a computational method for merging images from different depths of field into a composite image with all foreground objects in focus. Composite images generated by EDoF can be applied in automated image processing and pattern recognition systems. However, current algorithms for EDoF are computationally intensive and impractical, especially for applications such as medical diagnosis where rapid sample turnaround is important. Since foreground objects typically constitute a minor part of an image, the EDoF technique could be made to work much faster if only foreground regions are processed to make the composite image. We propose a novel algorithm called object-based extended depths of field (OEDoF) to address this issue. The OEDoF algorithm consists of four major modules: 1) color conversion, 2) object region identification, 3) good contrast pixel identification and 4) detail merging. First, the algorithm employs color conversion to enhance contrast followed by identification of foreground pixels. A composite image is constructed using only these foreground pixels, which dramatically reduces the computational time. We used 250 images obtained from 45 specimens of confirmed malaria infections to test our proposed algorithm. The resulting composite images with all in-focus objects were produced using the proposed OEDoF algorithm. We measured the performance of OEDoF in terms of image clarity (quality) and processing time. The features of interest selected by the OEDoF algorithm are comparable in quality with equivalent regions in images processed by the state-of-the-art complex wavelet EDoF algorithm; however, OEDoF required four times less processing time. This

System and method for magnetic current density imaging at ultra low magnetic fields

Science.gov (United States)

Espy, Michelle A.; George, John Stevens; Kraus, Robert Henry; Magnelind, Per; Matlashov, Andrei Nikolaevich; Tucker, Don; Turovets, Sergei; Volegov, Petr Lvovich

2016-02-09

Preferred systems can include an electrical impedance tomography apparatus electrically connectable to an object; an ultra low field magnetic resonance imaging apparatus including a plurality of field directions and disposable about the object; a controller connected to the ultra low field magnetic resonance imaging apparatus and configured to implement a sequencing of one or more ultra low magnetic fields substantially along one or more of the plurality of field directions; and a display connected to the controller, and wherein the controller is further configured to reconstruct a displayable image of an electrical current density in the object. Preferred methods, apparatuses, and computer program products are also disclosed.

Three-reflections telescope proposal as flat-field anastigmat for wide field observations at Dome C

Science.gov (United States)

Ferrari, M.; Lemaître, G.; Viotti, R.; La Padula, C.; Comte, G.; Blanc, M.; Boer, M.

It is now evident that the exceptional seeing at Dome C will allow, in the next years, to pursue astronomical programs with conditions better than at any other observatory in the world, and very close to space experiments. Considering a new type of wide-field telescope, particular astronomical programs could be well optimized for observations at Dome C such as surveys for the discovery and follow up of near-Earth asteroids, search for extra-solar planets using transit or micro-lensing events, and stellar luminosity variations. We propose to build a 1.5 2m class three-reflections telescope, with 1 1.5degree FOV, four times shorter than an equivalent Schmidt telescope, and providing a flat field without requiring a triplet- or quadruplet-lens corrector since its design is anastigmatic. We present the preliminary optical tests of such designs: MINITRUST1 and 2 are two 45cm identical prototypes based in France and Italy, and manufactured using active optics techniques.

Wide field and diffraction limited array camera for SIRTF

International Nuclear Information System (INIS)

Fazio, G.G.; Koch, D.G.; Melnick, G.J.

1986-01-01

The Infrared Array Camera for the Space Infrared Telescope Facility (SIRTF/IRAC) is capable of two-dimensional photometry in either a wide field or diffraction-limited mode over the wavelength interval from 2 to 30 microns. Three different two-dimensional direct readout (DRO) array detectors are being considered: Band 1-InSb or Si:In (2-5 microns) 128 x 128 pixels, Band 2-Si:Ga (5-18 microns) 64 x 64 pixels, and Band 3-Si:Sb (18-30 microns) 64 x 64 pixels. The hybrid DRO readout architecture has the advantages of low read noise, random pixel access with individual readout rates, and nondestructive readout. The scientific goals of IRAC are discussed, which are the basis for several important requirements and capabilities of the array camera: (1) diffraction-limited resolution from 2-30 microns, (2) use of the maximum unvignetted field of view of SIRTF, (3) simultaneous observations within the three infrared spectral bands, and (4) the capability for broad and narrow bandwidth spectral resolution. A strategy has been developed to minimize the total electronic and environmental noise sources to satisfy the scientific requirements. 7 references

Robustness of an artificially tailored fisheye imaging system with a curvilinear image surface

Science.gov (United States)

Lee, Gil Ju; Nam, Won Il; Song, Young Min

2017-11-01

Curved image sensors inspired by animal and insect eyes have provided a new development direction in next-generation digital cameras. It is known that natural fish eyes afford an extremely wide field of view (FOV) imaging due to the geometrical properties of the spherical lens and hemispherical retina. However, its inherent drawbacks, such as the low off-axis illumination and the fabrication difficulty of a 'dome-like' hemispherical imager, limit the development of bio-inspired wide FOV cameras. Here, a new type of fisheye imaging system is introduced that has simple lens configurations with a curvilinear image surface, while maintaining high off-axis illumination and a wide FOV. Moreover, through comparisons with commercial conventional fisheye designs, it is determined that the volume and required number of optical elements of the proposed design is practical while capturing the fundamental optical performances. Detailed design guidelines for tailoring the proposed optic system are also discussed.

WAMDII: The Wide Angle Michelson Doppler Imaging Interferometer

Science.gov (United States)

1992-01-01

As part of an effort to learn more about the upper atmosphere and how it is linked to the weather experienced each day, NASA and NRCC are jointly sponsoring the Wide Angle Michelson Doppler Imaging Interferometer (WAMDII) Mission. WAMDII will measure atmospheric temperature and wind speed in the upper atmosphere. In addition to providing data on the upper atmosphere, the wind speed and temperature readings WAMDII takes will also be highly useful in developing and updating computer simulated models of the upper atmosphere. These models are used in the design and testing of equipment and software for Shuttles, satellites, and reentry vehicles. In making its wind speed and temperature measurements, WAMDII examines the Earth's airglow, a faint photochemical luminescence caused by the influx of solar ultraviolet energy into the upper atmosphere. During periods of high solar flare activity, the amount of this UV energy entering the upper atmosphere increases, and this increase may effect airglow emissions.

Multistatic Array Sampling Scheme for Fast Near-Field Image Reconstruction

Science.gov (United States)

2016-01-01

human-sized scene in 0.048sec− 0.101sec. Index Terms—Microwave imaging, multistatic radar, Fast Fourier Transform (FFT). I. INTRODUCTION Near-field...configuration, but its computational demands are extreme. Fast Fourier Transform (FFT) imaging has long been used to efficiently construct images sampled...with the block diagram depicted in Fig. 4. It is noted that the multistatic to monostatic correction is valid over a finite imaging domain. However, as

The LCO/Gemini-South campaign for Deep Impact target Comet 9P/Tempel 1: Temporally resolved wide-field narrowband imaging results

Science.gov (United States)

Lederer, S. M.; Osip, D. J.; Thomas-Osip, J. E.; DeBuizer, J. M.; Mondragon, L. A.; Schweiger, D. L.; Viehweg, J.; SB Collaboration

2005-08-01

An extensive observing campaign to monitor Comet 9P/Tempel 1 will be conducted from 20 June to 19 July, 2005 at Las Campanas Observatory, Chile. These observations will precede and follow the impact of the Deep Impact projectile, which is likely to create a crater on the nucleus that will act as a fresh active area on the surface of the comet. Discreet nucleus active areas, believed to be the source of coma gas and dust jets, will likely result in changing morphology in the coma. We present the initial results of the wide-field narrowband visible imaging of the comet. Data will be taken with the 2.5m DuPont telescope from 27 June - 9 July, following the comet from 4 rotations prior to impact, to 4 rotations after impact using the narrowband Hale-Bopp filters, including CN, C2, and two continuum filters. These data will allow an accurate determination of the rotation state of the embedded nucleus immediately preceding the impact event as well as a measure of any changes to the rotation state due to the impact. In addition, modeling of these data will provide the total dust and gas production rates from the unaltered nucleus compared to the enhanced dust and gas emission from the newly created active region and freely sublimating pieces of mantle material ejected into the coma by the impactor. We will monitor temporal changes (on hours and days time-scales) in the morphology of both the gas and refractory components. We will use coma morphology studies to estimate the dust and gas outflow velocities and infer the presence of discreet nucleus source regions (pre- and post-impact). Of particular interest is the study of the gas-to-dust ratio and the ratio of the minor carbon species emitted from the newly created active region relative to the pre-impact coma environment.

Construction of imaging system for wide-field-range ESR spectra using localized microwave field and its case study of crystal orientation in suspension of copper sulfate pentahydrate (CuSO{sub 4}.5H{sub 2}O)

Energy Technology Data Exchange (ETDEWEB)

Tani, Atsushi [Department of Earth and Space Science, Graduate School of Science, Osaka University, 1-1 Machikaneyama Toyonaka, Osaka 560-0043 (Japan)]. E-mail: atani@ess.sci.osaka-u.ac.jp; Ueno, Takehiro [Department of Earth and Space Science, Graduate School of Science, Osaka University, 1-1 Machikaneyama Toyonaka, Osaka 560-0043 (Japan); Yamanaka, Chihiro [Department of Earth and Space Science, Graduate School of Science, Osaka University, 1-1 Machikaneyama Toyonaka, Osaka 560-0043 (Japan); Katsura, Makoto [Department of Earth and Space Science, Graduate School of Science, Osaka University, 1-1 Machikaneyama Toyonaka, Osaka 560-0043 (Japan); Ikeya, Motoji [Department of Earth and Space Science, Graduate School of Science, Osaka University, 1-1 Machikaneyama Toyonaka, Osaka 560-0043 (Japan)

2005-02-01

A scanning electron spin resonance (ESR) microscope using a localized microwave field was redesigned to measure ESR spectra from 0 to 400mT using electromagnets. Divalent copper ion (Cu{sup 2+}) in copper sulfate pentahydrate (CuSO{sub 4}.5H{sub 2}O) was imaged, after the powdered samples were cemented in silicone rubber under a magnetic field. The ratio of the two signal intensities at g=2.27 and 2.08 clearly indicates the orientation of the particles. This method can be used for mapping the local magnetic field and its direction.

THE SIZE EVOLUTION OF PASSIVE GALAXIES: OBSERVATIONS FROM THE WIDE-FIELD CAMERA 3 EARLY RELEASE SCIENCE PROGRAM

International Nuclear Information System (INIS)

Ryan, R. E. Jr.; McCarthy, P. J.; Cohen, S. H.; Rutkowski, M. J.; Mechtley, M. R.; Windhorst, R. A.; Yan, H.; Hathi, N. P.; Koekemoer, A. M.; Bond, H. E.; Bushouse, H.; O'Connell, R. W.; Balick, B.; Calzetti, D.; Crockett, R. M.; Disney, M.; Dopita, M. A.; Frogel, J. A.; Hall, D. N. B.; Holtzman, J. A.

2012-01-01

We present the size evolution of passively evolving galaxies at z ∼ 2 identified in Wide-Field Camera 3 imaging from the Early Release Science program. Our sample was constructed using an analog to the passive BzK galaxy selection criterion, which isolates galaxies with little or no ongoing star formation at z ∼> 1.5. We identify 30 galaxies in ∼40 arcmin 2 to H obs ∼ * ∼ 10 11 M ☉ ) undergo the strongest evolution from z ∼ 2 to the present. Parameterizing the size evolution as (1 + z) –α , we find a tentative scaling of α ≈ (– 0.6 ± 0.7) + (0.9 ± 0.4)log (M * /10 9 M ☉ ), where the relatively large uncertainties reflect the poor sampling in stellar mass due to the low numbers of high-redshift systems. We discuss the implications of this result for the redshift evolution of the M * -R e relation for red galaxies.

The application of mean field theory to image motion estimation.

Science.gov (United States)

Zhang, J; Hanauer, G G

1995-01-01

Previously, Markov random field (MRF) model-based techniques have been proposed for image motion estimation. Since motion estimation is usually an ill-posed problem, various constraints are needed to obtain a unique and stable solution. The main advantage of the MRF approach is its capacity to incorporate such constraints, for instance, motion continuity within an object and motion discontinuity at the boundaries between objects. In the MRF approach, motion estimation is often formulated as an optimization problem, and two frequently used optimization methods are simulated annealing (SA) and iterative-conditional mode (ICM). Although the SA is theoretically optimal in the sense of finding the global optimum, it usually takes many iterations to converge. The ICM, on the other hand, converges quickly, but its results are often unsatisfactory due to its "hard decision" nature. Previously, the authors have applied the mean field theory to image segmentation and image restoration problems. It provides results nearly as good as SA but with much faster convergence. The present paper shows how the mean field theory can be applied to MRF model-based motion estimation. This approach is demonstrated on both synthetic and real-world images, where it produced good motion estimates.

ORIENTATION AND DENSE RECONSTRUCTION OF UNORDERED TERRESTRIAL AND AERIAL WIDE BASELINE IMAGE SETS

Directory of Open Access Journals (Sweden)

J. Bartelsen

2012-07-01

Full Text Available In this paper we present an approach for detailed and precise automatic dense 3D reconstruction using images from consumer cameras. The major difference between our approach and many others is that we focus on wide-baseline image sets. We have combined and improved several methods, particularly, least squares matching, RANSAC, scale-space maxima and bundle adjustment, for robust matching and parameter estimation. Point correspondences and the five-point algorithm lead to relative orientation. Due to our robust matching method it is possible to orient images under much more unfavorable conditions, for instance concerning illumination changes or scale differences, than for often used operators such as SIFT. For dense reconstruction, we use our orientation as input for Semiglobal Matching (SGM resulting into dense depth images. The latter can be fused into a 2.5D model for eliminating the redundancy of the highly overlapping depth images. However, some applications require full 3D models. A solution to this problem is part of our current work, for which preliminary results are presented in this paper. With very small unmanned aerial systems (Micro UAS it is possible to acquire images which have a perspective similar to terrestrial images and can thus be combined with them. Such a combination is useful for an almost complete 3D reconstruction of urban scenes. We have applied our approach to several hundred aerial and terrestrial images and have generated detailed 2.5D and 3D models of urban areas.

THz near-field imaging of biological tissues employing synchrotron radiation (Invited Paper)

Science.gov (United States)

Schade, Ulrich; Holldack, Karsten; Martin, Michael C.; Fried, Daniel

2005-04-01

Terahertz scanning near-field infrared microscopy (SNIM) below 1 THz is demonstrated. The near-field technique benefits from the broadband and highly brilliant coherent synchrotron radiation (CSR) from an electron storage ring and from a detection method based on locking on to the intrinsic time structure of the synchrotron radiation. The scanning microscope utilizes conical waveguides as near-field probes with apertures smaller than the wavelength. Different cone approaches have been investigated to obtain maximum transmittance. Together with a Martin-Puplett spectrometer the set-up enables spectroscopic mapping of the transmittance of samples well below the diffraction limit. Spatial resolution down to about λ/40 at 2 wavenumbers (0.06 THz) is derived from the transmittance spectra of the near-field probes. The potential of the technique is exemplified by imaging biological samples. Strongly absorbing living leaves have been imaged in transmittance with a spatial resolution of 130 μm at about 12 wavenumbers (0.36 THz). The THz near-field images reveal distinct structural differences of leaves from different plants investigated. The technique presented also allows spectral imaging of bulky organic tissues. Human teeth samples of various thicknesses have been imaged between 2 and 20 wavenumbers (between 0.06 and 0.6 THz). Regions of enamel and dentin within tooth samples are spatially and spectrally resolved, and buried caries lesions are imaged through both the outer enamel and into the underlying dentin.

Digital color imaging

CERN Document Server

Fernandez-Maloigne, Christine; Macaire, Ludovic

2013-01-01

This collective work identifies the latest developments in the field of the automatic processing and analysis of digital color images.For researchers and students, it represents a critical state of the art on the scientific issues raised by the various steps constituting the chain of color image processing.It covers a wide range of topics related to computational color imaging, including color filtering and segmentation, color texture characterization, color invariant for object recognition, color and motion analysis, as well as color image and video indexing and retrieval. <

Shape from focus for large image fields

Czech Academy of Sciences Publication Activity Database

Pavlíček, Pavel; Hamarová, Ivana

2015-01-01

Roč. 54, č. 33 (2015), s. 9747-9751 ISSN 1559-128X R&D Projects: GA ČR GA13-12301S Institutional support: RVO:68378271 Keywords : shape from focus * large image fields * optically rough surface Subject RIV: BH - Optics , Masers, Lasers Impact factor: 1.598, year: 2015

Wide-Field Astronomical Surveys in the Next Decade

Energy Technology Data Exchange (ETDEWEB)

Strauss, Michael A.; /Princeton U.; Tyson, J.Anthony; /UC, Davis; Anderson, Scott F.; /Washington U., Seattle, Astron. Dept.; Axelrod, T.S.; /LSST Corp.; Becker, Andrew C.; /Washington U., Seattle, Astron. Dept.; Bickerton, Steven J.; /Princeton U.; Blanton, Michael R.; /New York U.; Burke, David L.; /SLAC; Condon, J.J.; /NRAO, Socorro; Connolly, A.J.; /Washington U., Seattle, Astron. Dept.; Cooray, Asantha R.; /UC, Irvine; Covey, Kevin R.; /Harvard U.; Csabai, Istvan; /Eotvos U.; Ferguson, Henry C.; /Baltimore, Space Telescope Sci.; Ivezic, Zeljko; /Washington U., Seattle, Astron. Dept.; Kantor, Jeffrey; /LSST Corp.; Kent, Stephen M.; /Fermilab; Knapp, G.R.; /Princeton U.; Myers, Steven T.; /NRAO, Socorro; Neilsen, Eric H., Jr.; /Fermilab; Nichol, Robert C.; /Portsmouth U., ICG /Harish-Chandra Res. Inst. /Caltech, IPAC /Potsdam, Max Planck Inst. /Harvard U. /Hawaii U. /UC, Berkeley, Astron. Dept. /Baltimore, Space Telescope Sci. /NOAO, Tucson /Carnegie Mellon U. /Chicago U., Astron. Astrophys. Ctr.

2011-11-14

Wide-angle surveys have been an engine for new discoveries throughout the modern history of astronomy, and have been among the most highly cited and scientifically productive observing facilities in recent years. This trend is likely to continue over the next decade, as many of the most important questions in astrophysics are best tackled with massive surveys, often in synergy with each other and in tandem with the more traditional observatories. We argue that these surveys are most productive and have the greatest impact when the data from the surveys are made public in a timely manner. The rise of the 'survey astronomer' is a substantial change in the demographics of our field; one of the most important challenges of the next decade is to find ways to recognize the intellectual contributions of those who work on the infrastructure of surveys (hardware, software, survey planning and operations, and databases/data distribution), and to make career paths to allow them to thrive.

All-weather calibration of wide-field optical and NIR surveys

Energy Technology Data Exchange (ETDEWEB)

Burke, David L. [SLAC National Accelerator Laboratory, Menlo Park, CA 94025 (United States); Saha, Abhijit; Claver, Jenna; Claver, Chuck [National Optical Astronomy Observatory, Tucson, AZ 85718 (United States); Axelrod, T. [Steward Observatory, University of Arizona, Tucson, AZ 85718 (United States); DePoy, Darren [Texas A and M University, College Station, TX 77843 (United States); Ivezić, Željko; Jones, Lynne [Department of Astronomy, University of Washington, Seattle, WA 98195 (United States); Smith, R. Chris [Cerro Tololo Inter-American Observatory, Casilla 603, La Serena (Chile); Stubbs, Christopher W., E-mail: daveb@slac.stanford.edu [Harvard Smithsonian Center for Astrophysics, Harvard University, Cambridge, MA 02138 (United States)

2014-01-01

The science goals for ground-based large-area surveys, such as the Dark Energy Survey, Pan-STARRS, and the Large Synoptic Survey Telescope, require calibration of broadband photometry that is stable in time and uniform over the sky to precisions of a percent or better. This performance will need to be achieved with data taken over the course of many years, and often in less than ideal conditions. This paper describes a strategy to achieve precise internal calibration of imaging survey data taken in less than 'photometric' conditions, and reports results of an observational study of the techniques needed to implement this strategy. We find that images of celestial fields used in this case study with stellar densities ∼1 arcmin{sup –2} and taken through cloudless skies can be calibrated with relative precision ∼0.5% (reproducibility). We report measurements of spatial structure functions of cloud absorption observed over a range of atmospheric conditions, and find it possible to achieve photometric measurements that are reproducible to 1% in images that were taken through cloud layers that transmit as little as 25% of the incident optical flux (1.5 magnitudes of extinction). We find, however, that photometric precision below 1% is impeded by the thinnest detectable cloud layers. We comment on implications of these results for the observing strategies of future surveys.

High Fidelity Raman Chemical Imaging of Materials

Science.gov (United States)

Bobba, Venkata Nagamalli Koteswara Rao

The development of high fidelity Raman imaging systems is important for a number of application areas including material science, bio-imaging, bioscience and healthcare, pharmaceutical analysis, and semiconductor characterization. The use of Raman imaging as a characterization tool for detecting the amorphous and crystalline regions in the biopolymer poly-L-lactic acid (PLLA) is the precis of my thesis. In the first chapter, a brief insight about the basics of Raman spectroscopy, Raman chemical imaging, Raman mapping, and Raman imaging techniques has been provided. The second chapter contains details about the successful development of tailored sample of PLLA. Biodegradable polymers are used in areas of tissue engineering, agriculture, packaging, and in medical field for drug delivery, implant devices, and surgical sutures. Detailed information about the sample preparation and characterization of these cold-drawn PLLA polymer substrates has been provided. Wide-field Raman hyperspectral imaging using an acousto-optic tunable filter (AOTF) was demonstrated in the early 1990s. The AOTF contributed challenges such as image walk, distortion, and image blur. A wide-field AOTF Raman imaging system has been developed as part of my research and methods to overcome some of the challenges in performing AOTF wide-field Raman imaging are discussed in the third chapter. This imaging system has been used for studying the crystalline and amorphous regions on the cold-drawn sample of PLLA. Of all the different modalities that are available for performing Raman imaging, Raman point-mapping is the most extensively used method. The ease of obtaining the Raman hyperspectral cube dataset with a high spectral and spatial resolution is the main motive of performing this technique. As a part of my research, I have constructed a Raman point-mapping system and used it for obtaining Raman hyperspectral image data of various minerals, pharmaceuticals, and polymers. Chapter four offers

High throughput second harmonic imaging for label-free biological applications

KAUST Repository

Macias Romero, Carlos; Didier, Marie E P; Jourdain, Pascal; Marquet, Pierre; Magistretti, Pierre J.; Tarun, Orly B.; Zubkovs, Vitalijs; Radenovic, Aleksandra; Roke, Sylvie

2014-01-01

Second harmonic generation (SHG) is inherently sensitive to the absence of spatial centrosymmetry, which can render it intrinsically sensitive to interfacial processes, chemical changes and electrochemical responses. Here, we seek to improve the imaging throughput of SHG microscopy by using a wide-field imaging scheme in combination with a medium-range repetition rate amplified near infrared femtosecond laser source and gated detection. The imaging throughput of this configuration is tested by measuring the optical image contrast for different image acquisition times of BaTiO3 nanoparticles in two different wide-field setups and one commercial point-scanning configuration. We find that the second harmonic imaging throughput is improved by 2-3 orders of magnitude compared to point-scan imaging. Capitalizing on this result, we perform low fluence imaging of (parts of) living mammalian neurons in culture.

Gas Distributions in Comet ISON’s Coma: Concurrent Integral-Field Spectroscopy and Narrow-band Imaging.

Science.gov (United States)

Schmidt, Carl; Johnson, Robert E.; Baumgardner, Jeffrey; Mendillo, Michael

2014-11-01

At a solar distance of 0.44 AU, Oort cloud comet C/2012 S1 (ISON) exhibited an outburst phase that was observed by small telescopes at the McDonald Observatory. In conjunction with narrow-band (14Å) imaging over a wide-field, an image-slicer spectrograph ( 20,000) simultaneously measured the spatial distribution of ISON’s coma over a 1.6 x 2.7 arcminute field made up of 246 individual spectra. More than fifty emission lines from C2, NH2, CO, H2O+ and Na were observed within a single Echelle order spanning 5868Å to 5930Å. Spatial reconstructions of these species reveal that ISON’s coma was quite elongated several thousand km along the axis perpendicular to its motion. The ion tail appeared distinctly broader than the neutral Na tail, providing strong evidence that Na in the coma did not originate by dissociative recombination of a sodium bearing molecular ion. Production rates increased from 1.6 ± 0.3 x 1023 to 5.8 ± 1 x 1023 Na atoms/s within 24 hours, outgassing much less than comparable comets relative to ISON’s water production. The anti-sunward Na tail was imaged >106 km from the nucleus. Its distribution indicates origins both near the nucleus and in the dust tail, with the ratio of these Na sources varying on hourly timescales due to outburst activity.

Ultrasound versus high field magnetic resonance imaging in rheumatoid arthritis

DEFF Research Database (Denmark)

Tan, York Kiat; Østergaard, Mikkel; Bird, Paul

2014-01-01

Over the past decade there have been significant advances in the field of musculoskeletal imaging, especially in the application of ultrasound (US) and magnetic resonance imaging (MRI) to the management of rheumatoid arthritis (RA). Both modalities offer significant advantages over the previous...

AN INTEGRATED RANSAC AND GRAPH BASED MISMATCH ELIMINATION APPROACH FOR WIDE-BASELINE IMAGE MATCHING

Directory of Open Access Journals (Sweden)

M. Hasheminasab

2015-12-01

Full Text Available In this paper we propose an integrated approach in order to increase the precision of feature point matching. Many different algorithms have been developed as to optimizing the short-baseline image matching while because of illumination differences and viewpoints changes, wide-baseline image matching is so difficult to handle. Fortunately, the recent developments in the automatic extraction of local invariant features make wide-baseline image matching possible. The matching algorithms which are based on local feature similarity principle, using feature descriptor as to establish correspondence between feature point sets. To date, the most remarkable descriptor is the scale-invariant feature transform (SIFT descriptor , which is invariant to image rotation and scale, and it remains robust across a substantial range of affine distortion, presence of noise, and changes in illumination. The epipolar constraint based on RANSAC (random sample consensus method is a conventional model for mismatch elimination, particularly in computer vision. Because only the distance from the epipolar line is considered, there are a few false matches in the selected matching results based on epipolar geometry and RANSAC. Aguilariu et al. proposed Graph Transformation Matching (GTM algorithm to remove outliers which has some difficulties when the mismatched points surrounded by the same local neighbor structure. In this study to overcome these limitations, which mentioned above, a new three step matching scheme is presented where the SIFT algorithm is used to obtain initial corresponding point sets. In the second step, in order to reduce the outliers, RANSAC algorithm is applied. Finally, to remove the remained mismatches, based on the adjacent K-NN graph, the GTM is implemented. Four different close range image datasets with changes in viewpoint are utilized to evaluate the performance of the proposed method and the experimental results indicate its robustness and

Depth-resolved ballistic imaging in a low-depth-of-field optical Kerr gated imaging system

Energy Technology Data Exchange (ETDEWEB)

Zheng, Yipeng; Tan, Wenjiang, E-mail: tanwenjiang@mail.xjtu.edu.cn; Si, Jinhai; Ren, YuHu; Xu, Shichao; Hou, Xun [Key Laboratory for Physical Electronics and Devices of the Ministry of Education and Shaanxi Key Lab of Information Photonic Technique, School of Electronics and Information Engineering, Xi' an Jiaotong University, Xianning-xilu 28, Xi' an 710049 (China); Tong, Junyi [Departments of Applied Physics, Xi' an University of Technology, Xi' an 710048 (China)

2016-09-07

We demonstrate depth-resolved imaging in a ballistic imaging system, in which a heterodyned femtosecond optical Kerr gate is introduced to extract useful imaging photons for detecting an object hidden in turbid media and a compound lens is proposed to ensure both the depth-resolved imaging capability and the long working distance. Two objects of about 15-μm widths hidden in a polystyrene-sphere suspension have been successfully imaged with approximately 600-μm depth resolution. Modulation-transfer-function curves with the object in and away from the object plane have also been measured to confirm the depth-resolved imaging capability of the low-depth-of-field (low-DOF) ballistic imaging system. This imaging approach shows potential for application in research of the internal structure of highly scattering fuel spray.

Using Opaque Image Blur for Real-Time Depth-of-Field Rendering and Image-Based Motion Blur

DEFF Research Database (Denmark)

Kraus, Martin

2013-01-01

While depth of field is an important cinematographic means, its use in real-time computer graphics is still limited by the computational costs that are necessary to achieve a sufficient image quality. Specifically, color bleeding artifacts between objects at different depths are most effectively...... that the opaque image blur can also be used to add motion blur effects to images in real time....

Dynamics of annular bright field imaging in scanning transmission electron microscopy

International Nuclear Information System (INIS)

Findlay, S.D.; Shibata, N.; Sawada, H.; Okunishi, E.; Kondo, Y.; Ikuhara, Y.

2010-01-01

We explore the dynamics of image formation in the so-called annular bright field mode in scanning transmission electron microscopy, whereby an annular detector is used with detector collection range lying within the cone of illumination, i.e. the bright field region. We show that this imaging mode allows us to reliably image both light and heavy columns over a range of thickness and defocus values, and we explain the contrast mechanisms involved. The role of probe and detector aperture sizes is considered, as is the sensitivity of the method to intercolumn spacing and local disorder.

MEASUREMENTS OF STRAIN FIELDS DUE TO NANOSCALE PRECIPITATES USING THE PHASE IMAGE METHOD

Directory of Open Access Journals (Sweden)

Patricia Donnadieu

2011-05-01

Full Text Available Owing the phase image method (Hytch, 1998, strain fields can be derived from HREM images. The method is here applied to the nanoscale precipitates responsible for hardening in Aluminum alloys. Since the method is a very sensitive one, we have examined the impact of several aspects of the image quality (noise, fluctuations, distortion. The strain field information derived from the HREM image analysis is further introduced in a simulation of the dislocation motion in the matrix.

In vivo wide-field multispectral dosimeter for use in ALA-PpIX based photodynamic therapy of skin

Science.gov (United States)

LaRochelle, Ethan P. M.; Davis, Scott C.; de Souza, Ana Luiza Ribeiro; Pogue, Brian W.

2017-02-01

Photodynamic therapy (PDT) for Actinic Kertoses (AK) using aminoluvelinic acid (ALA) is an FDA-approved treatment, which is generally effective, yet response rates vary. The origin of the variability is not well characterized, but may be related to inter-patient variability in the production of protoporphyrin IX (PpIX). While fiber-based point probe systems provide a method for measuring PpIX production, these measurements have demonstrated large spatial and inter-operator variability. Thus, in an effort to improve patient-specific dosimetry and treatment it is important to develop a robust system that accounts for spatial variability and reduces the chance of operator errors. To address this need, a wide-field multispectral imaging system was developed that is capable of quantifying maps of PpIX in both liquid phantoms and in vivo experiments, focusing on high sensitivity light signals. The system uses both red and blue excitation to elicit a fluorescent response at varying skin depths. A ten-position filter wheel with bandpass filters ranging from 635nm to 710nm are used to capture images along the emission band. A linear least-square spectral fitting algorithm provides the ability to decouple background autofluorescence from PpIX fluorescence, which has improved the system sensitivity by an order of magnitude, detecting nanomolar PpIX concentrations in liquid phantoms in the presence of 2% whole blood and 2% intralipid.

Scheimpflug with computational imaging to extend the depth of field of iris recognition systems

Science.gov (United States)

Sinharoy, Indranil

Despite the enormous success of iris recognition in close-range and well-regulated spaces for biometric authentication, it has hitherto failed to gain wide-scale adoption in less controlled, public environments. The problem arises from a limitation in imaging called the depth of field (DOF): the limited range of distances beyond which subjects appear blurry in the image. The loss of spatial details in the iris image outside the small DOF limits the iris image capture to a small volume-the capture volume. Existing techniques to extend the capture volume are usually expensive, computationally intensive, or afflicted by noise. Is there a way to combine the classical Scheimpflug principle with the modern computational imaging techniques to extend the capture volume? The solution we found is, surprisingly, simple; yet, it provides several key advantages over existing approaches. Our method, called Angular Focus Stacking (AFS), consists of capturing a set of images while rotating the lens, followed by registration, and blending of the in-focus regions from the images in the stack. The theoretical underpinnings of AFS arose from a pair of new and general imaging models we developed for Scheimpflug imaging that directly incorporates the pupil parameters. The model revealed that we could register the images in the stack analytically if we pivot the lens at the center of its entrance pupil, rendering the registration process exact. Additionally, we found that a specific lens design further reduces the complexity of image registration making AFS suitable for real-time performance. We have demonstrated up to an order of magnitude improvement in the axial capture volume over conventional image capture without sacrificing optical resolution and signal-to-noise ratio. The total time required for capturing the set of images for AFS is less than the time needed for a single-exposure, conventional image for the same DOF and brightness level. The net reduction in capture time can

Colour-magnitude diagrams of star clusters in the Magellanic Clouds from wide-field electronography

International Nuclear Information System (INIS)

Andersen, J.; Walker, M.F.

1984-01-01

Utilizing the good image quality and large field available with the 9-cm McMullan electronographic camera when attached to the Danish 1.54-m Ritchey-Chretien reflector at La Silla, Chile, a number of star clusters in the Magellanic Clouds have been observed in order to determine their colour-magnitude diagrams with proper correction for the field star contribution. In Hodge 11, the first cluster to be reported from this programme, good measurements have been obtained of 180 stars in the annular field 34 <= R <= 71 arcsec of the cluster itself, and of 154 stars in a nearby control field of similar area, to a limit of V of the order of 22. (author)

Volumetric fluorescence retinal imaging in vivo over a 30-degree field of view by oblique scanning laser ophthalmoscopy (oSLO).

Science.gov (United States)

Zhang, Lei; Song, Weiye; Shao, Di; Zhang, Sui; Desai, Manishi; Ness, Steven; Roy, Sayon; Yi, Ji

2018-01-01

While fluorescent contrast is widely used in ophthalmology, three-dimensional (3D) fluorescence retinal imaging over a large field of view (FOV) has been challenging. In this paper, we describe a novel oblique scanning laser ophthalmoscopy (oSLO) technique that provides 3D volumetric fluorescence retinal imaging with only one raster scan. The technique utilizes scanned oblique illumination and angled detection to obtain fluorescent cross-sectional images, analogous to optical coherence tomography (OCT) line scans (or B-scans). By breaking the coaxial optical alignment used in conventional retinal imaging modalities, depth resolution is drastically improved. To demonstrate the capability of oSLO, we have performed in vivo volumetric fluorescein angiography (FA) of the rat retina with ~25μm depth resolution and over a 30° FOV. Using depth segmentation, oSLO can obtain high contrast images of the microvasculature down to single capillaries in 3D. The multi-modal nature of oSLO also allows for seamless combination with simultaneous OCT angiography.

Historic Methods for Capturing Magnetic Field Images

Science.gov (United States)

Kwan, Alistair

2016-01-01

I investigated two late 19th-century methods for capturing magnetic field images from iron filings for historical insight into the pedagogy of hands-on physics education methods, and to flesh out teaching and learning practicalities tacit in the historical record. Both methods offer opportunities for close sensory engagement in data-collection…

High-field magnetic resonance imaging of the human temporal lobe

Directory of Open Access Journals (Sweden)

Luis M. Colon-Perez

2015-01-01

Conclusions: Fresh ex vivo MR imaging, along with tractography, revealed complex intra-temporal structural variation corresponding to neuronal cell body layers, dendritic fields, and axonal projection systems evident histologically. This is the first study to describe in detail the human temporal lobe structural organization using high-field MR imaging and tractography. By preserving the 3-dimensional structures of the hippocampus and surrounding structures, specific changes in anatomy may inform us about the changes that occur in TLE in relation to the disease process and structural underpinnings in epilepsy-related memory dysfunction.

Dark-field hyperlens: Super-resolution imaging of weakly scattering objects

DEFF Research Database (Denmark)

Repän, Taavi; Lavrinenko, Andrei; Zhukovsky, Sergei

2015-01-01

: We propose a device for subwavelength optical imaging based on a metal-dielectric multilayer hyperlens designed in such a way that only large-wavevector (evanescent) waves are transmitted while all propagating (small-wavevector) waves from the object area are blocked by the hyperlens. We...... numerically demonstrate that as the result of such filtering, the image plane only contains scattered light from subwavelength features of the objects and is completely free from background illumination. Similar in spirit to conventional dark-field microscopy, the proposed dark-field hyperlens is shown...

PT-symmetric planar devices for field transformation and imaging

International Nuclear Information System (INIS)

Valagiannopoulos, C A; Monticone, F; Alù, A

2016-01-01

The powerful tools of transformation optics (TO) allow an effective distortion of a region of space by carefully engineering the material inhomogeneity and anisotropy, and have been successfully applied in recent years to control electromagnetic fields in many different scenarios, e.g., to realize invisibility cloaks and planar lenses. For various field transformations, it is not necessary to use volumetric inhomogeneous materials, and suitably designed ultrathin metasurfaces with tailored spatial or spectral responses may be able to realize similar functionalities within smaller footprints and more robust mechanisms. Here, inspired by the concept of metamaterial TO lenses, we discuss field transformations enabled by parity-time (PT) symmetric metasurfaces, which can emulate negative refraction. We first analyze a simple realization based on homogeneous and local metasurfaces to achieve negative refraction and imaging, and we then extend our results to arbitrary PT-symmetric two-port networks to realize aberration-free planar imaging. (paper)

A prototype tap test imaging system: Initial field test results

Science.gov (United States)

Peters, J. J.; Barnard, D. J.; Hudelson, N. A.; Simpson, T. S.; Hsu, D. K.

2000-05-01

This paper describes a simple, field-worthy tap test imaging system that gives quantitative information about the size, shape, and severity of defects and damages. The system consists of an accelerometer, electronic circuits for conditioning the signal and measuring the impact duration, a laptop PC and data acquisition and processing software. The images are generated manually by tapping on a grid printed on a plastic sheet laid over the part's surface. A mechanized scanner is currently under development. The prototype has produced images for a variety of aircraft composite and metal honeycomb structures containing flaws, damages, and repairs. Images of the local contact stiffness, deduced from the impact duration using a spring model, revealed quantitatively the stiffness reduction due to flaws and damages, as well as the stiffness enhancement due to substructures. The system has been field tested on commercial and military aircraft as well as rotor blades and engine decks on helicopters. Field test results will be shown and the operation of the system will be demonstrated.—This material is based upon work supported by the Federal Aviation Administration under Contract #DTFA03-98-D-00008, Delivery Order No. IA016 and performed at Iowa State University's Center for NDE as part of the Center for Aviation Systems Reliability program.

Details of 1π sr wide acceptance angle electrostatic lens for electron energy and two-dimensional angular distribution analysis combined with real space imaging

International Nuclear Information System (INIS)

Tóth, László; Matsuda, Hiroyuki; Matsui, Fumihiko; Goto, Kentaro; Daimon, Hiroshi

2012-01-01

We propose a new 1π sr Wide Acceptance Angle Electrostatic Lens (WAAEL), which works as a photoemission electron microscope (PEEM), a highly sensitive display-type electron energy and two-dimensional angular distribution analyzer. It can display two-dimensional angular distributions of charged particles within the acceptance angle of ±60° that is much larger than the largest acceptance angle range so far and comparable to the display-type spherical mirror analyzer developed by Daimon et al. . It has good focusing capabilities with 5-times magnification and 27(4) μm lateral-resolution. The relative energy resolution is typically from 2 to 5×10 -3 depending on the diameter of energy aperture and the emission area on the sample. Although, the lateral resolution of the presented lens is far from those are available nowadays, but this is the first working model that can form images using charged particles collected from 1π sr wide acceptance angle. The realization of such lens system is one of the first possible steps towards reaching the field of imaging type atomic resolution electron microscopy Feynman et al. Here some preliminary results are shown.

Far-field superresolution by imaging of resonance scattering

KAUST Repository

Schuster, Gerard T.; Huang, Y.

2014-01-01

We show that superresolution imaging in the far-field region of the sources and receivers is theoretically and practically possible if migration of resonant multiples is employed. A resonant multiple is one that bounces back and forth between two

Fundus imaging with a nasal endoscope

Directory of Open Access Journals (Sweden)

P Mahesh Shanmugam

2015-01-01

Full Text Available Wide field fundus imaging is needed to diagnose, treat, and follow-up patients with retinal pathology. This is more applicable for pediatric patients as repeated evaluation is a challenge. The presently available imaging machines though provide high definition images, but carry the obvious disadvantages of either being costly or bulky or sometimes both, which limits its usage only to large centers. We hereby report a technique of fundus imaging using a nasal endoscope coupled with viscoelastic. A regular nasal endoscope with viscoelastic coupling was placed on the cornea to image the fundus of infants under general anesthesia. Wide angle fundus images of various fundus pathologies in infants could be obtained easily with readily available instruments and without the much financial investment for the institutes.

Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis.

Science.gov (United States)

Ferlauto, Laura; Airaghi Leccardi, Marta Jole Ildelfonsa; Chenais, Naïg Aurelia Ludmilla; Gilliéron, Samuel Charles Antoine; Vagni, Paola; Bevilacqua, Michele; Wolfensberger, Thomas J; Sivula, Kevin; Ghezzi, Diego

2018-03-08

Retinal prostheses have been developed to fight blindness in people affected by outer retinal layer dystrophies. To date, few hundred patients have received a retinal implant. Inspired by intraocular lenses, we have designed a foldable and photovoltaic wide-field epiretinal prosthesis (named POLYRETINA) capable of stimulating wireless retinal ganglion cells. Here we show that within a visual angle of 46.3 degrees, POLYRETINA embeds 2215 stimulating pixels, of which 967 are in the central area of 5 mm, it is foldable to allow implantation through a small scleral incision, and it has a hemispherical shape to match the curvature of the eye. We demonstrate that it is not cytotoxic and respects optical and thermal safety standards; accelerated ageing shows a lifetime of at least 2 years. POLYRETINA represents significant progress towards the improvement of both visual acuity and visual field with the same device, a current challenging issue in the field.

ON THE BINARY FREQUENCY OF THE LOWEST MASS MEMBERS OF THE PLEIADES WITH HUBBLE SPACE TELESCOPE WIDE FIELD CAMERA 3

International Nuclear Information System (INIS)

Garcia, E. V.; Dupuy, Trent J.; Allers, Katelyn N.; Liu, Michael C.; Deacon, Niall R.

2015-01-01

We present the results of a Hubble Space Telescope Wide Field Camera 3 (WFC3) imaging survey of 11 of the lowest mass brown dwarfs in the Pleiades known (25–40 M Jup ). These objects represent the predecessors to T dwarfs in the field. Using a semi-empirical binary point-spread function (PSF)-fitting technique, we are able to probe to 0.″ 03 (0.75 pixel), better than 2x the WFC3/UVIS diffraction limit. We did not find any companions to our targets. From extensive testing of our PSF-fitting method on simulated binaries, we compute detection limits which rule out companions to our targets with mass ratios of ≳0.7 and separations ≳4 AU. Thus, our survey is the first to attain the high angular resolution needed to resolve brown dwarf binaries in the Pleiades at separations that are most common in the field population. We constrain the binary frequency over this range of separation and mass ratio of 25–40 M Jup Pleiades brown dwarfs to be <11% for 1σ (<26% at 2σ). This binary frequency is consistent with both younger and older brown dwarfs in this mass range

Technology Development for 3-D Wide Swath Imaging Supporting ACE

Science.gov (United States)

Racette, Paul; Heymsfield, Gerry; Li, Lihua; Mclinden, Matthew; Park, Richard; Cooley, Michael; Stenger, Pete; Hand, Thomas

2014-01-01

The National Academy of Sciences Decadal Survey (DS) Aerosol-Cloud-Ecosystems Mission (ACE) aims to advance our ability to observe and predict changes to the Earth's hydrological cycle and energy balance in response to climate forcing, especially those changes associated with the effects of aerosol on clouds and precipitation. ACE is focused on obtaining measurements to reduce the uncertainties in current climate models arising from the lack in understanding of aerosol-cloud interactions. As part of the mission instrument suite, a dual-frequency radar comprised of a fixed-beam 94 gigahertz (W-band) radar and a wide-swath 35 gigahertz (Ka-band) imaging radar has been recommended by the ACE Science Working Group.In our 2010 Instrument Incubator Program project, we've developed a radar architecture that addresses the challenge associated with achieving the measurement objectives through an innovative, shared aperture antenna that allows dual-frequency radar operation while achieving wide-swath (100 kilometers) imaging at Ka-band. The antenna system incorporates 2 key technologies; a) a novel dual-band reflectorreflectarray and b) a Ka-band Active Electronically Scanned Array (AESA) feed module. The dual-band antenna is comprised of a primary cylindrical reflectorreflectarray surface illuminated by a point-focus W-band feed (compatible with a quasi-optical beam waveguide feed, such as that employed on CloudSat); the Ka-band AESA line feed provides wide-swath across-track scanning. The benefits of this shared-aperture approach include significant reductions in ACE satellite payload size, weight, and cost, as compared to a two aperture approach. Four objectives were addressed in our project. The first entailed developing the tools for the analysis and design of reflectarray antennas, assessment of candidate reflectarray elements, and validation using test coupons. The second objective was to develop a full-scale aperture design utilizing the reflectarray surface and to

Three-dimensional magnetic nanoparticle imaging using small field gradient and multiple pickup coils

Energy Technology Data Exchange (ETDEWEB)

Sasayama, Teruyoshi, E-mail: sasayama@sc.kyushu-u.ac.jp; Tsujita, Yuya; Morishita, Manabu; Muta, Masahiro; Yoshida, Takashi; Enpuku, Keiji

2017-04-01

We propose a magnetic particle imaging (MPI) method based on third harmonic signal detection using a small field gradient and multiple pickup coils. First, we developed a system using two pickup coils and performed three-dimensional detection of two magnetic nanoparticle (MNP) samples, which were spaced 15 mm apart. In the experiments, an excitation field strength of 1.6 mT was used at an operating frequency of 3 kHz. A DC gradient field with a typical value of 0.2 T/m was also used to produce the so-called field-free line. A third harmonic signal generated by the MNP samples was detected using the two pickup coils, and the samples were then mechanically scanned to obtain field maps. The field maps were subsequently analyzed using the nonnegative least squares method to obtain three-dimensional position information for the MNP samples. The results show that the positions of the two MNP samples were estimated with good accuracy, despite the small field gradient used. Further improvement in MPI performance will be achieved by increasing the number of pickup coils used. - Highlights: • 3D magnetic particle imaging system combining field-free line and two pickup coils. • Imaging method based on third harmonic signal detection and small field gradient. • Nonnegative least squares method for 3D magnetic nanoparticle image reconstruction. • High spatial resolution despite use of small field gradient.

How images make world politics

DEFF Research Database (Denmark)

Hansen, Lene

2015-01-01

This article introduces international icons to the field of International Relations. International icons are freestanding images that are widely circulated, recognised, and emotionally responded to. International icons come in the form of foreign policy icons familiar to a specific domestic...... of the hooded prisoner widely claimed to be emblematic of the Abu Ghraib prison scandal....

Breast cancer diagnosis by thermal imaging in the fields of medical and artificial intelligence sciences: review article

Directory of Open Access Journals (Sweden)

Hossein Ghayoumi Zadeh

2016-09-01

Full Text Available Breast cancer is the most common cancer in women and one of the leading of death among them. The high and increasing incidence of the disease and its difficult treatment specifically in advanced stages, imposes hard situations for different countries’ health systems. Body temperature is a natural criteria for the diagnosis of diseases. In recent decades extensive research has been conducted to increase the use of thermal cameras and obtain a close relationship between heat and temperature of the skin's physiology. Thermal imaging (thermography applies infrared method which is fast, non-invasive, non-contact and flexibile to monitor the temperature of the human body. This paper investigates highly diversified studies implemented before and after the year 2000. And it emphasizes mostly on the newely published articles including: performance and evaluation of thermal imaging, the various aspects of imaging as well as The available technology in this field and its disadvantages in the diagnosis of breast cancer. Thermal imaging has been adopted by researchers in the fields of medicine and biomedical engineering for the diagnosis of breast cancer. With the advent of modern infrared cameras, data acquisition and processing techniques, it is now possible to have real time high resolution thermographic images, which is likely to surge further research in this field.  Thermography does not provide information on the structures of the breast morphology, but it provides performance information of temperature and breast tissue vessels. It is assumed that the functional changes occured before the start of the structural changes which is the result of disease or cancer. These days, thermal imaging method has not been established as an applicative method for screening or diagnosing purposes in academic centers. But there are different centers that adopt this method for the diognosis and examining purposes. Thermal imaging is an effective method which is

Method for imaging with low frequency electromagnetic fields

Science.gov (United States)

Lee, Ki H.; Xie, Gan Q.

1994-01-01

A method for imaging with low frequency electromagnetic fields, and for interpreting the electromagnetic data using ray tomography, in order to determine the earth conductivity with high accuracy and resolution. The imaging method includes the steps of placing one or more transmitters, at various positions in a plurality of transmitter holes, and placing a plurality of receivers in a plurality of receiver holes. The transmitters generate electromagnetic signals which diffuse through a medium, such as earth, toward the receivers. The measured diffusion field data H is then transformed into wavefield data U. The traveltimes corresponding to the wavefield data U, are then obtained, by charting the wavefield data U, using a different regularization parameter .alpha. for each transform. The desired property of the medium, such as conductivity, is then derived from the velocity, which in turn is constructed from the wavefield data U using ray tomography.

Inverse transformation algorithm of transient electromagnetic field and its high-resolution continuous imaging interpretation method

International Nuclear Information System (INIS)

Qi, Zhipeng; Li, Xiu; Lu, Xushan; Zhang, Yingying; Yao, Weihua

2015-01-01

We introduce a new and potentially useful method for wave field inverse transformation and its application in transient electromagnetic method (TEM) 3D interpretation. The diffusive EM field is known to have a unique integral representation in terms of a fictitious wave field that satisfies a wave equation. The continuous imaging of TEM can be accomplished using the imaging methods in seismic interpretation after the diffusion equation is transformed into a fictitious wave equation. The interpretation method based on the imaging of a fictitious wave field could be used as a fast 3D inversion method. Moreover, the fictitious wave field possesses some wave field features making it possible for the application of a wave field interpretation method in TEM to improve the prospecting resolution.Wave field transformation is a key issue in the migration imaging of a fictitious wave field. The equation in the wave field transformation belongs to the first class Fredholm integration equation, which is a typical ill-posed equation. Additionally, TEM has a large dynamic time range, which also facilitates the weakness of this ill-posed problem. The wave field transformation is implemented by using pre-conditioned regularized conjugate gradient method. The continuous imaging of a fictitious wave field is implemented by using Kirchhoff integration. A synthetic aperture and deconvolution algorithm is also introduced to improve the interpretation resolution. We interpreted field data by the method proposed in this paper, and obtained a satisfying interpretation result. (paper)

Particle image velocimetry measurements of 2-dimensional velocity field around twisted tape

Energy Technology Data Exchange (ETDEWEB)

Song, Min Seop; Park, So Hyun; Kim, Eung Soo, E-mail: kes7741@snu.ac.kr

2016-11-01

Highlights: • Measurements of the flow field in a pipe with twisted tape were conducted by particle image velocimetry (PIV). • A novel matching index of refraction technique utilizing 3D printing and oil mixture was adopted to make the test section transparent. • Undistorted particle images were clearly captured in the presence of twisted tape. • 2D flow field in the pipe with twisted tape revealed the characteristic two-peak velocity profile. - Abstract: Twisted tape is a passive component used to enhance heat exchange in various devices. It induces swirl flow that increases the mixing of fluid. Thus, ITER selected the twisted tape as one of the candidates for turbulence promoting in the divertor cooling. Previous study was mainly focused on the thermohydraulic performance of the twisted tape. As detailed data on the velocity field around the twisted tape was insufficient, flow visualization study was performed to provide fundamental data on velocity field. To visualize the flow in a complex structure, novel matching index of refraction technique was used with 3-D printing and mixture of anise and mineral oil. This technique enables the camera to capture undistorted particle image for velocity field measurement. Velocity fields at Reynolds number 1370–9591 for 3 different measurement plane were obtained through particle image velocimetry. The 2-dimensional averaged velocity field data were obtained from 177 pair of instantaneous velocity fields. It reveals the characteristic two-peak flow motion in axial direction. In addition, the normalized velocity profiles were converged with increase of Reynolds numbers. Finally, the uncertainty of the result data was analyzed.

Current status on image processing in medical fields in Japan

International Nuclear Information System (INIS)

Atsumi, Kazuhiko

1979-01-01

Information on medical images are classified in the two patterns. 1) off-line images on films-x-ray films, cell image, chromosome image etc. 2) on-line images detected through sensors, RI image, ultrasonic image, thermogram etc. These images are divided into three characteristic, two dimensional three dimensional and dynamic images. The research on medical image processing have been reported in several meeting in Japan and many fields on images have been studied on RI, thermogram, x-ray film, x-ray-TV image, cancer cell, blood cell, bacteria, chromosome, ultrasonics, and vascular image. Processing on TI image useful and easy because of their digital displays. Software on smoothing, restoration (iterative approximation), fourier transformation, differentiation and subtration. Image on stomach and chest x-ray films have been processed automatically utilizing computer system. Computed Tomography apparatuses have been already developed in Japan and automated screening instruments on cancer cells and recently on blood cells classification have been also developed. Acoustical holography imaging and moire topography have been also studied in Japan. (author)

3D palmprint and hand imaging system based on full-field composite color sinusoidal fringe projection technique.

Science.gov (United States)

Zhang, Zonghua; Huang, Shujun; Xu, Yongjia; Chen, Chao; Zhao, Yan; Gao, Nan; Xiao, Yanjun

2013-09-01

Palmprint and hand shape, as two kinds of important biometric characteristics, have been widely studied and applied to human identity recognition. The existing research is based mainly on 2D images, which lose the third-dimensional information. The biological features extracted from 2D images are distorted by pressure and rolling, so the subsequent feature matching and recognition are inaccurate. This paper presents a method to acquire accurate 3D shapes of palmprint and hand by projecting full-field composite color sinusoidal fringe patterns and the corresponding color texture information. A 3D imaging system is designed to capture and process the full-field composite color fringe patterns on hand surface. Composite color fringe patterns having the optimum three fringe numbers are generated by software and projected onto the surface of human hand by a digital light processing projector. From another viewpoint, a color CCD camera captures the deformed fringe patterns and saves them for postprocessing. After compensating for the cross talk and chromatic aberration between color channels, three fringe patterns are extracted from three color channels of a captured composite color image. Wrapped phase information can be calculated from the sinusoidal fringe patterns with high precision. At the same time, the absolute phase of each pixel is determined by the optimum three-fringe selection method. After building up the relationship between absolute phase map and 3D shape data, the 3D palmprint and hand are obtained. Color texture information can be directly captured or demodulated from the captured composite fringe pattern images. Experimental results show that the proposed method and system can yield accurate 3D shape and color texture information of the palmprint and hand shape.

A Variational Level Set Approach Based on Local Entropy for Image Segmentation and Bias Field Correction.

Science.gov (United States)