Sample records for wide field imager

  1. Wide Field Imager for Athena (United States)

    Meidinger, Norbert; Nandra, Kirpal; Rau, Arne; Plattner, Markus; WFI proto-Consortium


    The Wide Field Imager focal plane instrument on ATHENA will combine unprecedented survey power through its large field of view of 40 arcmin with a high count-rate capability (> 1 Crab). The energy resolution of the silicon sensor is state-of-the-art in the energy band of interest from 0.1 keV to 15 keV. At energy of 6 keV for example, the full width at half maximum of the line shall be not worse than 150 eV until the end of the mission. The performance is accomplished by a set of DEPFET active pixel sensor matrices with a pixel size well suited to the angular resolution of 5 arc sec (on-axis) of the mirror system.Each DEPFET pixel is a combined detector-amplifier structure with a MOSFET integrated onto a fully depleted 450 micron thick silicon bulk. Two different types of DEPFET sensors are planned for the WFI instrument: A set of large-area sensors to cover the physical size of 14 cm x 14 cm in the focal plane and a single gateable DEPFET sensor matrix optimized for the high count rate capability of the instrument. An overview will be given about the presently developed instrument concept and design, the status of the technology development, and the expected performance. An outline of the project organization, the model philosophy as well as the schedule will complete the presentation about the Wide Field Imager for Athena.

  2. Wide-Field Imaging Using Nitrogen Vacancies (United States)

    Englund, Dirk Robert (Inventor); Trusheim, Matthew Edwin (Inventor)


    Nitrogen vacancies in bulk diamonds and nanodiamonds can be used to sense temperature, pressure, electromagnetic fields, and pH. Unfortunately, conventional sensing techniques use gated detection and confocal imaging, limiting the measurement sensitivity and precluding wide-field imaging. Conversely, the present sensing techniques do not require gated detection or confocal imaging and can therefore be used to image temperature, pressure, electromagnetic fields, and pH over wide fields of view. In some cases, wide-field imaging supports spatial localization of the NVs to precisions at or below the diffraction limit. Moreover, the measurement range can extend over extremely wide dynamic range at very high sensitivity.

  3. IOT Overview: Wide-Field Imaging (United States)

    Selman, F. J.

    The Wide Field Imager (WFI) instrument at La Silla has been the workhorse of wide-field imaging instruments at ESO for several years. In this contribution I will summarize the issues relating to its productivity for the community both in terms of the quality and quantity of data that has come out of it. Although only surveys of limited scope have been completed using WFI, it is ESO's stepping-stone to the new generation of survey telescopes.

  4. Wide field imaging problems in radio astronomy (United States)

    Cornwell, T. J.; Golap, K.; Bhatnagar, S.


    The new generation of synthesis radio telescopes now being proposed, designed, and constructed face substantial problems in making images over wide fields of view. Such observations are required either to achieve the full sensitivity limit in crowded fields or for surveys. The Square Kilometre Array (SKA Consortium, Tech. Rep., 2004), now being developed by an international consortium of 15 countries, will require advances well beyond the current state of the art. We review the theory of synthesis radio telescopes for large fields of view. We describe a new algorithm, W projection, for correcting the non-coplanar baselines aberration. This algorithm has improved performance over those previously used (typically an order of magnitude in speed). Despite the advent of W projection, the computing hardware required for SKA wide field imaging is estimated to cost up to $500M (2015 dollars). This is about half the target cost of the SKA. Reconfigurable computing is one way in which the costs can be decreased dramatically.

  5. The Wide Field Imager for Athena (United States)

    Rau, A.; Nandra, K.; Meidinger, N.; Plattner, M.


    The Wide Field Imager (WFI) is one of the two scientific instruments of Athena, ESA's next large X-ray Observatory with launch in 2028. The instrument will provide two defining capabilities to the mission sensitive wide-field imaging spectroscopy and excellent high-count rate performance. It will do so with the use of two separate detectors systems, the Large Detector Array (LDA) optimized for its field of view (40'×40') with a 100 fold survey speed increase compared to existing X-ray missions, and the Fast Detector (FD) tweaked for high throughput and low pile-up for point sources as bright as the Crab. In my talk I will present the key performance parameters of the instrument and their links to the scientific goals of Athena and summarize the status of the ongoing development activities.

  6. The Wide Field Imager Instrument for Athena


    Meidinger, Norbert; Eder, Josef; Eraerds, Tanja; Nandra, Kirpal; Pietschner, Daniel; Plattner, Markus; Rau, Arne; Strecker, Rafael


    The WFI (Wide Field Imager) instrument is planned to be one of two complementary focal plane cameras on ESA's next X-ray observatory Athena. It combines unprecedented survey power through its large field of view of 40 amin x 40 amin together with excellent count rate capability (larger than 1 Crab). The energy resolution of the silicon sensor is state-of-the-art in the energy band of interest from 0.2 keV to 15 keV, e.g. the full width at half maximum of a line at 7 keV will be better than 17...

  7. Athena Wide Field Imager key science drivers (United States)

    Rau, Arne; Nandra, Kirpal; Aird, James; Comastri, Andrea; Dauser, Thomas; Merloni, Andrea; Pratt, Gabriel W.; Reiprich, Thomas H.; Fabian, Andy C.; Georgakakis, Antonis; Güdel, Manuel; RóŻańska, Agata; Sanders, Jeremy S.; Sasaki, Manami; Vaughan, Simon; Wilms, Jörn; Meidinger, Norbert


    The Wide Field Imager (WFI) is one of two instruments for the Advanced Telescope for High-ENergy Astrophysics (Athena). In this paper we summarise three of the many key science objectives for the WFI { the formation and growth of supermassive black holes, non-gravitational heating in clusters of galaxies, and spin measurements of stellar mass black holes { and describe their translation into the science requirements and ultimately instrument requirements. The WFI will be designed to provide excellent point source sensitivity and grasp for performing wide area surveys, surface brightness sensitivity, survey power, and absolute temperature and density calibration for in-depth studies of the outskirts of nearby clusters of galaxies and very good high-count rate capability, throughput, and low pile-up, paired with very good spectral resolution, for detailed explorations of bright Galactic compact objects.

  8. The Wide Field Imager instrument for Athena (United States)

    Meidinger, Norbert; Barbera, Marco; Emberger, Valentin; Fürmetz, Maria; Manhart, Markus; Müller-Seidlitz, Johannes; Nandra, Kirpal; Plattner, Markus; Rau, Arne; Treberspurg, Wolfgang


    ESA's next large X-ray mission ATHENA is designed to address the Cosmic Vision science theme 'The Hot and Energetic Universe'. It will provide answers to the two key astrophysical questions how does ordinary matter assemble into the large-scale structures we see today and how do black holes grow and shape the Universe. The ATHENA spacecraft will be equipped with two focal plane cameras, a Wide Field Imager (WFI) and an X-ray Integral Field Unit (X-IFU). The WFI instrument is optimized for state-of-the-art resolution spectroscopy over a large field of view of 40 amin x 40 amin and high count rates up to and beyond 1 Crab source intensity. The cryogenic X-IFU camera is designed for high-spectral resolution imaging. Both cameras share alternately a mirror system based on silicon pore optics with a focal length of 12 m and large effective area of about 2 m2 at an energy of 1 keV. Although the mission is still in phase A, i.e. studying the feasibility and developing the necessary technology, the definition and development of the instrumentation made already significant progress. The herein described WFI focal plane camera covers the energy band from 0.2 keV to 15 keV with 450 μm thick fully depleted back-illuminated silicon active pixel sensors of DEPFET type. The spatial resolution will be provided by one million pixels, each with a size of 130 μm x 130 μm. The time resolution requirement for the WFI large detector array is 5 ms and for the WFI fast detector 80 μs. The large effective area of the mirror system will be completed by a high quantum efficiency above 90% for medium and higher energies. The status of the various WFI subsystems to achieve this performance will be described and recent changes will be explained here.

  9. The wide field imager instrument for Athena (United States)

    Meidinger, Norbert; Nandra, Kirpal; Plattner, Markus; Porro, Matteo; Rau, Arne; Santangelo, Andrea E.; Tenzer, Chris; Wilms, Jörn


    The "Hot and Energetic Universe" has been selected as the science theme for ESA's L2 mission, scheduled for launch in 2028. The proposed Athena X-ray observatory provides the necessary capabilities to achieve the ambitious goals of the science theme. The X-ray mirrors are based on silicon pore optics technology and will have a 12 m focal length. Two complementary camera systems are foreseen which can be moved in and out of the focal plane by an interchange mechanism. These instruments are the actively shielded micro-calorimeter spectrometer X-IFU and the Wide Field Imager (WFI). The WFI will combine an unprecedented survey power through its large field of view of 40 arcmin with a high countrate capability (approx. 1 Crab). It permits a state-of-the-art energy resolution in the energy band of 0.1 keV to 15 keV during the entire mission lifetime (e.g. FWHM serial analog output. The architecture of sensor and readout ASIC allows readout in full frame mode and window mode as well by addressing selectively arbitrary sub-areas of the sensor allowing time resolution in the order of 10 μs. The further detector electronics has mainly the following tasks: digitization, pre-processing and telemetry of event data as well as supply and control of the detector system. Although the sensor will already be equipped with an on-chip light blocking filter, a filter wheel is necessary to provide an additional external filter, an on-board calibration source, an open position for outgassing, and a closed position for protection of the sensor. The sensor concept provides high quantum efficiency over the entire energy band and we intend to keep the instrumental background as low as possible by designing a graded Z-shield around the sensor. All these properties make the WFI a very powerful survey instrument, significantly surpassing currently existing observatories and in addition allow high-time resolution of the brightest X-ray sources with low pile-up and high efficiency. This

  10. The wide field imager instrument for Athena (United States)

    Meidinger, Norbert; Eder, Josef; Eraerds, Tanja; Nandra, Kirpal; Pietschner, Daniel; Plattner, Markus; Rau, Arne; Strecker, Rafael


    The WFI (Wide Field Imager) instrument is planned to be one of two complementary focal plane cameras on ESA's next X-ray observatory Athena. It combines unprecedented survey power through its large field of view of 40 amin x 40 amin together with excellent count rate capability (>= 1 Crab). The energy resolution of the silicon sensor is state-of-the-art in the energy band of interest from 0.2 keV to 15 keV, e.g. the full width at half maximum of a line at 7 keV will be MOSFET integrated onto a fully depleted 450 μm thick silicon bulk. Two detectors are planned for the WFI instrument: A large-area detector comprising four sensors with a total of 1024 x 1024 pixels and a fast detector optimized for high count rate observations. This high count rate capable detector permits for bright point sources with an intensity of 1 Crab a throughput of more than 80% and a pile-up of less than 1%. The fast readout of the DEPFET pixel matrices is facilitated by an ASIC development, called VERITAS-2. Together with the Switcher-A, a control ASIC that allows for operation of the DEPFET in rolling shutter mode, these elements form the key components of the WFI detectors. The detectors are surrounded by a graded-Z shield, which has in particular the purpose to avoid fluorescence lines that would contribute to the instrument background. Together with ultra-thin coating of the sensor and particle identification by the detector itself, the particle induced background shall be minimized in order to achieve the scientific requirement of a total instrumental background value smaller than 5 x 10-3 cts/cm2/s/keV. Each detector has its dedicated detector electronics (DE) for supply and data acquisition. Due to the high frame rate in combination with the large pixel array, signal correction and event filtering have to be done on-board and in real-time as the raw data rate would by far exceed the feasible telemetry rate. The data streams are merged and compressed in the Instrument Control and

  11. Wide-Field, Deep UV Raman Hyperspectral Imager Project (United States)

    National Aeronautics and Space Administration — ChemImage Sensor Systems (CISS), teaming with the University of South Carolina, proposes a revolutionary wide-field Raman hyperspectral imaging system capable of...

  12. Ultra-wide-field imaging in diabetic retinopathy. (United States)

    Ghasemi Falavarjani, Khalil; Tsui, Irena; Sadda, Srinivas R


    Since 1991, 7-field images captured with 30-50 degree cameras in the Early Treatment Diabetic Retinopathy Study were the gold standard for fundus imaging to study diabetic retinopathy. Ultra-wide-field images cover significantly more area (up to 82%) of the fundus and with ocular steering can in many cases image 100% of the fundus ("panretinal"). Recent advances in image analysis of ultra-wide-field imaging allow for precise measurements of the peripheral retinal lesions. There is a growing consensus in the literature that ultra-wide-field imaging improves detection of peripheral lesions in diabetic retinopathy and leads to more accurate classification of the disease. There is discordance among studies, however, on the correlation between peripheral diabetic lesions and diabetic macular edema and optimal management strategies to treat diabetic retinopathy. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. WFIRST: Astrometry with the Wide-Field Imager (United States)

    Bellini, Andrea; WFIRST Astrometry Working Group


    The wide field of view and stable, sharp images delivered by WFIRST's Wide-Field Imager make it an excellent instrument for astrometry, one of five major discovery areas identified in the 2010 Decadal Survey. Compared to the Hubble Space Telescope, WFIRST's wider field of view with similar image quality will provide hundreds more astrometric targets per image as well as background galaxies and stars with precise positions in the Gaia catalog. In addition, WFIRST will operate in the infrared, a wavelength regime where the most precise astrometry has so far been achieved with adaptive optics images from large ground-based telescopes. WFIRST will provide at least a factor of three improvement in astrometry over the current state of the art in this wavelength range, while spanning a field of view thousands of times larger. WFIRST is thus poised to make major contributions to multiple science topics in which astrometry plays an important role, without major alterations to the planned mission or instrument. We summarize a few of the most compelling science cases where WFIRST astrometry could prove transformational.

  14. Wide Field-of-View Fluorescence Imaging of Coral Reefs (United States)

    Treibitz, Tali; Neal, Benjamin P.; Kline, David I.; Beijbom, Oscar; Roberts, Paul L. D.; Mitchell, B. Greg; Kriegman, David


    Coral reefs globally are declining rapidly because of both local and global stressors. Improved monitoring tools are urgently needed to understand the changes that are occurring at appropriate temporal and spatial scales. Coral fluorescence imaging tools have the potential to improve both ecological and physiological assessments. Although fluorescence imaging is regularly used for laboratory studies of corals, it has not yet been used for large-scale in situ assessments. Current obstacles to effective underwater fluorescence surveying include limited field-of-view due to low camera sensitivity, the need for nighttime deployment because of ambient light contamination, and the need for custom multispectral narrow band imaging systems to separate the signal into meaningful fluorescence bands. Here we describe the Fluorescence Imaging System (FluorIS), based on a consumer camera modified for greatly increased sensitivity to chlorophyll-a fluorescence, and we show high spectral correlation between acquired images and in situ spectrometer measurements. This system greatly facilitates underwater wide field-of-view fluorophore surveying during both night and day, and potentially enables improvements in semi-automated segmentation of live corals in coral reef photographs and juvenile coral surveys. PMID:25582836

  15. Wide-field fundus imaging with trans-palpebral illumination (United States)

    Toslak, Devrim; Thapa, Damber; Chen, Yanjun; Erol, Muhammet Kazim; Chan, R. V. Paul; Yao, Xincheng


    In conventional fundus imaging devices, transpupillary illumination is used for illuminating the inside of the eye. In this method, the illumination light is directed into the posterior segment of the eye through the cornea and passes the pupillary area. As a result of sharing the pupillary area for the illumination beam and observation path, pupil dilation is typically necessary for wide-angle fundus examination, and the field of view is inherently limited. An alternative approach is to deliver light from the sclera. It is possible to image a wider retinal area with transcleral-illumination. However, the requirement of physical contact between the illumination probe and the sclera is a drawback of this method. We report here trans-palpebral illumination as a new method to deliver the light through the upper eyelid (palpebra). For this study, we used a 1.5 mm diameter fiber with a warm white LED light source. To illuminate the inside of the eye, the fiber illuminator was placed at the location corresponding to the pars plana region. A custom designed optical system was attached to a digital camera for retinal imaging. The optical system contained a 90 diopter ophthalmic lens and a 25 diopter relay lens. The ophthalmic lens collected light coming from the posterior of the eye and formed an aerial image between the ophthalmic and relay lenses. The aerial image was captured by the camera through the relay lens. An adequate illumination level was obtained to capture wide angle fundus images within ocular safety limits, defined by the ISO 15004-2: 2007 standard. This novel trans-palpebral illumination approach enables wide-angle fundus photography without eyeball contact and pupil dilation.

  16. Development of the wide field imager for Athena (United States)

    Meidinger, Norbert; Eder, Josef; Fürmetz, Maria; Nandra, Kirpal; Pietschner, Daniel; Plattner, Markus; Rau, Arne; Reiffers, Jonas; Strecker, Rafael; Barbera, Marco; Brand, Thorsten; Wilms, Jörn


    The WFI (Wide Field Imager) instrument is planned to be one of two complementary focal plane cameras on ESA's next X-ray observatory Athena. It combines unprecedented survey power through its large field of view of 40 arcmin x 40 arcmin together with excellent count-rate capability (>= 1 Crab). The energy resolution of the silicon sensor is state-of-the-art in the energy band of interest from 0.2 keV to 15 keV, e.g. the full width at half maximum of a line at 6 keV will be MOSFET integrated onto a fully depleted 450 μm thick silicon bulk. Two different types of DEPFET sensors are planned for the WFI instrument: A set of four large-area sensors to cover the physical size of 14 cm x 14 cm in the focal plane and a single smaller gateable DEPFET sensor matrix optimized for high count-rate observations. Here we present the conceptual design of the instrument with focus on the critical subsystems and describe the instrument performance expectations. An outline of the model philosophy and the project organization completes the presentation.

  17. Wide-field single photon counting imaging with an ultrafast camera and an image intensifier

    Energy Technology Data Exchange (ETDEWEB)

    Zanda, Gianmarco, E-mail: [King' s College London, Department of Physics, Strand, London WC2R 2LS (United Kingdom); Sergent, Nicolas; Green, Mark; Levitt, James A. [King' s College London, Department of Physics, Strand, London WC2R 2LS (United Kingdom); Petrasek, Zdenek [Biotechnologisches Zentrum, Technische Universitaet Dresden, Tatzberg 47/49, 01307 Dresden (Germany); Suhling, Klaus, E-mail: [King' s College London, Department of Physics, Strand, London WC2R 2LS (United Kingdom)


    We are reporting a method for wide-field photon counting imaging using a CMOS camera with a 40 kHz frame rate coupled with a three-stage image intensifier mounted on a standard fluorescence microscope. This system combines high frame rates with single photon sensitivity. The output of the phosphor screen, consisting of single-photon events, is collected by a CMOS camera allowing to create a wide-field image with parallel positional and timing information of each photon. Using a pulsed excitation source and a luminescent sample, the arrival time of hundreds of photons can be determined simultaneously in many pixels with microsecond resolution.

  18. Wide-field single photon counting imaging with an ultrafast camera and an image intensifier (United States)

    Zanda, Gianmarco; Sergent, Nicolas; Green, Mark; Levitt, James A.; Petrášek, Zdeněk; Suhling, Klaus


    We are reporting a method for wide-field photon counting imaging using a CMOS camera with a 40 kHz frame rate coupled with a three-stage image intensifier mounted on a standard fluorescence microscope. This system combines high frame rates with single photon sensitivity. The output of the phosphor screen, consisting of single-photon events, is collected by a CMOS camera allowing to create a wide-field image with parallel positional and timing information of each photon. Using a pulsed excitation source and a luminescent sample, the arrival time of hundreds of photons can be determined simultaneously in many pixels with microsecond resolution.


    Energy Technology Data Exchange (ETDEWEB)

    Bhatnagar, S.; Rau, U.; Golap, K., E-mail:, E-mail:, E-mail: [National Radio Astronomy Observatory, Socorro, NM 87801 (United States)


    Variations of the antenna primary beam (PB) pattern as a function of time, frequency, and polarization form one of the dominant direction-dependent effects at most radio frequency bands. These gains may also vary from antenna to antenna. The A-Projection algorithm, published earlier, accounts for the effects of the narrow-band antenna PB in full polarization. In this paper, we present the wide-band A-Projection algorithm (WB A-Projection) to include the effects of wide bandwidth in the A-term itself and show that the resulting algorithm simultaneously corrects for the time, frequency, and polarization dependence of the PB. We discuss the combination of the WB A-Projection and the multi-term multi-frequency synthesis (MT-MFS) algorithm for simultaneous mapping of the sky brightness distribution and the spectral index distribution across a wide field of view. We also discuss the use of the narrow-band A-Projection algorithm in hybrid imaging schemes that account for the frequency dependence of the PB in the image domain.

  20. Structured illumination for wide-field Raman imaging of cell membranes (United States)

    Chen, Houkai; Wang, Siqi; Zhang, Yuquan; Yang, Yong; Fang, Hui; Zhu, Siwei; Yuan, Xiaocong


    Although the diffraction limit still restricts their lateral resolution, conventional wide-field Raman imaging techniques offer fast imaging speeds compared with scanning schemes. To extend the lateral resolution of wide-field Raman microscopy using filters, standing-wave illumination technique is used, and an improvement of lateral resolution by a factor of more than two is achieved. Specifically, functionalized surface enhanced Raman scattering nanoparticles are employed to strengthen the desired scattering signals to label cell membranes. This wide-field Raman imaging technique affords various significant opportunities in the biological applications.

  1. Wide Field-of-View (FOV) Soft X-Ray Imager Project (United States)

    National Aeronautics and Space Administration — The Wide Field-of-View (FOV) Soft X-Ray Imager proposes to be a state-of-art instrument with applications for numerous heliospheric and planetary...

  2. Wide-field TCSPC-based fluorescence lifetime imaging (FLIM) microscopy (United States)

    Suhling, Klaus; Hirvonen, Liisa M.; Becker, Wolfgang; Smietana, Stefan; Netz, Holger; Milnes, James; Conneely, Thomas; Le Marois, Alix; Jagutzki, Ottmar


    Time-correlated single photon counting (TCSPC) is a widely used, sensitive, precise, robust and mature technique to measure photon arrival times in applications such as fluorescence spectroscopy and microscopy, light detection and ranging (lidar) and optical tomography. Wide-field TCSPC detection techniques, where the position and the arrival time of the photons are recorded simultaneously, have seen several advances in the last few years, from the microsecond to the picosecond time scale. Here, we summarise some of our recent work in this field with emphasis on microsecond resolution phosphorescence lifetime imaging (PLIM) and nanosecond fluorescence lifetime imaging (FLIM) microscopy.

  3. Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications. (United States)

    Xu, Jingjiang; Wei, Wei; Song, Shaozhen; Qi, Xiaoli; Wang, Ruikang K


    Recent advances in optical coherence tomography (OCT)-based angiography have demonstrated a variety of biomedical applications in the diagnosis and therapeutic monitoring of diseases with vascular involvement. While promising, its imaging field of view (FOV) is however still limited (typically less than 9 mm(2)), which somehow slows down its clinical acceptance. In this paper, we report a high-speed spectral-domain OCT operating at 1310 nm to enable wide FOV up to 750 mm(2). Using optical microangiography (OMAG) algorithm, we are able to map vascular networks within living biological tissues. Thanks to 2,048 pixel-array line scan InGaAs camera operating at 147 kHz scan rate, the system delivers a ranging depth of ~7.5 mm and provides wide-field OCT-based angiography at a single data acquisition. We implement two imaging modes (i.e., wide-field mode and high-resolution mode) in the OCT system, which gives highly scalable FOV with flexible lateral resolution. We demonstrate scalable wide-field vascular imaging for multiple finger nail beds in human and whole brain in mice with skull left intact at a single 3D scan, promising new opportunities for wide-field OCT-based angiography for many clinical applications.

  4. Wide-field mid-infrared hyperspectral imaging of adhesives using a bolometer camera


    Sugawara, Shigeru; Nakayama, Yoshihiko; Taniguchi, Hideya; Ishimaru, Ichiro


    By combining a bolometer detector with an imaging-type interferometer, an inexpensive, easy-to-handle wide-field mid-infrared hyperspectral imaging apparatus was produced. We measured the distributions of four types of thin adhesive layers on an aluminium plate and analysed the results using correlation coefficients to visualise the distribution of various adhesives that cannot be discerned by the naked eye or conventional methods such as visible/near-infrared spectroscopic/fluorescent photog...

  5. Astro-WISE Processing of Wide-field Images and Other Data

    NARCIS (Netherlands)

    Buddelmeijer, H.; Williams, O.R.; McFarland, J. P.; Belikov, A.; Ballester, P.; Egret, D.; Lorente, N.P.F.

    Astro-WISE (Vriend et al. 2012) is the Astronomical Wide-field Imaging System for Europe (Valentijn et al. 2007). It is a scientific information system which consists of hardware and software federated over about a dozen institutes throughout Europe. It has been developed to exploit the ever

  6. Wide-field Imaging of the Environments of LITTLE THINGS Dwarf Irregular Galaxies (United States)

    Hunter, Deidre A.; Melton, Casey; Leshin, Stephen; Wong, Alson; Clark, Maurice; Kamienski, Jerald; Moriya, Netzer; Packwood, Burley; Birket, Bob; Edwards, William; Millward, Mervyn; Wheelband, Ian


    We have obtained wide-field images of 36 of the 41 LITTLE THINGS (Local Irregulars That Trace Luminosity Extremes, The H I Nearby Galaxy Survey) nearby (limiting magnitudes of the images range from 19.7 to 28.3 mag arcsec‑2, with a median value of 25.9 mag arcsec‑2. We did not find any unknown companions. Two of the LITTLE THINGS galaxies, NGC 4163 and NGC 4214, and the fainter dwarf, UGCA 276, lie potentially within 100 kpc of each other, but our imaging does not reveal any stellar bridge between the galaxies. This project was part of the Lowell Amateur Research Initiative.

  7. Compressive imaging for difference image formation and wide-field-of-view target tracking (United States)



    Use of imaging systems for performing various situational awareness tasks in military and commercial settings has a long history. There is increasing recognition, however, that a much better job can be done by developing non-traditional optical systems that exploit the task-specific system aspects within the imager itself. In some cases, a direct consequence of this approach can be real-time data compression along with increased measurement fidelity of the task-specific features. In others, compression can potentially allow us to perform high-level tasks such as direct tracking using the compressed measurements without reconstructing the scene of interest. In this dissertation we present novel advancements in feature-specific (FS) imagers for large field-of-view surveillence, and estimation of temporal object-scene changes utilizing the compressive imaging paradigm. We develop these two ideas in parallel. In the first case we show a feature-specific (FS) imager that optically multiplexes multiple, encoded sub-fields of view onto a common focal plane. Sub-field encoding enables target tracking by creating a unique connection between target characteristics in superposition space and the target's true position in real space. This is accomplished without reconstructing a conventional image of the large field of view. System performance is evaluated in terms of two criteria: average decoding time and probability of decoding error. We study these performance criteria as a function of resolution in the encoding scheme and signal-to-noise ratio. We also include simulation and experimental results demonstrating our novel tracking method. In the second case we present a FS imager for estimating temporal changes in the object scene over time by quantifying these changes through a sequence of difference images. The difference images are estimated by taking compressive measurements of the scene. Our goals are twofold. First, to design the optimal sensing matrix for taking

  8. A Wide Field Auroral Imager (WFAI for low Earth orbit missions

    Directory of Open Access Journals (Sweden)

    N. P. Bannister


    Full Text Available A comprehensive understanding of the solar wind interaction with Earth's coupled magnetosphere-ionosphere system requires an ability to observe the charged particle environment and auroral activity from the same platform, generating particle and photon image data which are matched in time and location. While unambiguous identification of the particles giving rise to the aurora requires a Low Earth Orbit satellite, obtaining adequate spatial coverage of aurorae with the relatively limited field of view of current space bourne auroral imaging systems requires much higher orbits. A goal for future satellite missions, therefore, is the development of compact, wide field-of-view optics permitting high spatial and temporal resolution ultraviolet imaging of the aurora from small spacecraft in low polar orbit. Microchannel plate optics offer a method of achieving the required performance. We describe a new, compact instrument design which can observe a wide field-of-view with the required spatial resolution. We report the focusing of 121.6 nm radiation using a spherically-slumped, square-pore microchannel plate with a focal length of 32 mm and an F number of 0.7. Measurements are compared with detailed ray-trace simulations of imaging performance. The angular resolution is 2.7±0.2° for the prototype, corresponding to a footprint ~33 km in diameter for an aurora altitude of 110 km and a spacecraft altitude of 800 km. In preliminary analysis, a more recent optic has demonstrated a full width at half maximum of 5.0±0.3 arcminutes, corresponding to a footprint of ~1 km from the same spacecraft altitude. We further report the imaging properties of a convex microchannel plate detector with planar resistive anode readout; this detector, whose active surface has a radius of curvature of only 100 mm, is shown to meet the spatial resolution and sensitivity requirements of the new wide field auroral imager (WFAI.

  9. Optically sectioned wide-field fluorescence lifetime imaging endoscopy enabled by structured illumination (Conference Presentation) (United States)

    Hinsdale, Taylor; Malik, Bilal H.; Rico-Jimenez, Jose J.; Jo, Javier A.; Maitland, Kristen C.


    We present a wide-field fluorescence lifetime imaging (FLIM) system with optical sectioning by structured illumination microscopy (SIM). FLIM measurements were made using a time gated ICCD camera in conjunction with a pulsed nitrogen dye laser operating at 450 nm. Intensity images were acquired at multiple time delays from a trigger initiated by a laser pulse to create a wide-field FLIM image, which was then combined with three phase SIM to provide optical sectioning. Such a mechanism has the potential to increase the reliability and accuracy of the FLIM measurements by rejecting background intensity. SIM also provides the opportunity to create volumetric FLIM images with the incorporation of scanning mechanisms for the sample plane. We present multiple embodiments of such a system: one as a free space endoscope and the other as a fiber microendoscope enabled by the introduction of a fiber bundle. Finally, we demonstrate the efficacy of such an imaging system by imaging dyes embedded in a tissue phantom.

  10. Speckle correlation resolution enhancement of wide-field fluorescence imaging (Conference Presentation) (United States)

    Yilmaz, Hasan


    Structured illumination enables high-resolution fluorescence imaging of nanostructures [1]. We demonstrate a new high-resolution fluorescence imaging method that uses a scattering layer with a high-index substrate as a solid immersion lens [2]. Random scattering of coherent light enables a speckle pattern with a very fine structure that illuminates the fluorescent nanospheres on the back surface of the high-index substrate. The speckle pattern is raster-scanned over the fluorescent nanospheres using a speckle correlation effect known as the optical memory effect. A series of standard-resolution fluorescence images per each speckle pattern displacement are recorded by an electron-multiplying CCD camera using a commercial microscope objective. We have developed a new phase-retrieval algorithm to reconstruct a high-resolution, wide-field image from several standard-resolution wide-field images. We have introduced phase information of Fourier components of standard-resolution images as a new constraint in our algorithm which discards ambiguities therefore ensures convergence to a unique solution. We demonstrate two-dimensional fluorescence images of a collection of nanospheres with a deconvolved Abbe resolution of 116 nm and a field of view of 10 µm × 10 µm. Our method is robust against optical aberrations and stage drifts, therefore excellent for imaging nanostructures under ambient conditions. [1] M. G. L. Gustafsson, J. Microsc. 198, 82-87 (2000). [2] H. Yilmaz, E. G. van Putten, J. Bertolotti, A. Lagendijk, W. L. Vos, and A. P. Mosk, Optica 2, 424-429 (2015).

  11. Cost-effective and compact wide-field fluorescent imaging on a cell-phone. (United States)

    Zhu, Hongying; Yaglidere, Oguzhan; Su, Ting-Wei; Tseng, Derek; Ozcan, Aydogan


    We demonstrate wide-field fluorescent and darkfield imaging on a cell-phone with compact, light-weight and cost-effective optical components that are mechanically attached to the existing camera unit of the cell-phone. For this purpose, we used battery powered light-emitting diodes (LEDs) to pump the sample of interest from the side using butt-coupling, where the pump light was guided within the sample cuvette to uniformly excite the specimen. The fluorescent emission from the sample was then imaged using an additional lens that was positioned right in front of the existing lens of the cell-phone camera. Because the excitation occurs through guided waves that propagate perpendicular to our detection path, an inexpensive plastic colour filter was sufficient to create the dark-field background required for fluorescent imaging, without the need for a thin-film interference filter. We validate the performance of this platform by imaging various fluorescent micro-objects in 2 colours (i.e., red and green) over a large field-of-view (FOV) of ∼81 mm(2) with a raw spatial resolution of ∼20 μm. With additional digital processing of the captured cell-phone images, through the use of compressive sampling theory, we demonstrate ∼2 fold improvement in our resolving power, achieving ∼10 μm resolution without a trade-off in our FOV. Further, we also demonstrate darkfield imaging of non-fluorescent specimen using the same interface, where this time the scattered light from the objects is detected without the use of any filters. The capability of imaging a wide FOV would be exceedingly important to probe large sample volumes (e.g., >0.1 mL) of e.g., blood, urine, sputum or water, and for this end we also demonstrate fluorescent imaging of labeled white-blood cells from whole blood samples, as well as water-borne pathogenic protozoan parasites such as Giardia Lamblia cysts. Weighing only ∼28 g (∼1 ounce), this compact and cost-effective fluorescent imaging platform

  12. Wide-field and high-resolution optical imaging for early detection of oral neoplasia (United States)

    Pierce, Mark C.; Schwarz, Richard A.; Rosbach, Kelsey; Roblyer, Darren; Muldoon, Tim; Williams, Michelle D.; El-Naggar, Adel K.; Gillenwater, Ann M.; Richards-Kortum, Rebecca


    Current procedures for oral cancer screening typically involve visual inspection of the entire tissue surface at risk under white light illumination. However, pre-cancerous lesions can be difficult to distinguish from many benign conditions when viewed under these conditions. We have developed wide-field (macroscopic) imaging system which additionally images in cross-polarized white light, narrowband reflectance, and fluorescence imaging modes to reduce specular glare, enhance vascular contrast, and detect disease-related alterations in tissue autofluorescence. We have also developed a portable system to enable high-resolution (microscopic) evaluation of cellular features within the oral mucosa in situ. This system is a wide-field epi-fluorescence microscope coupled to a 1 mm diameter, flexible fiber-optic imaging bundle. Proflavine solution was used to specifically label cell nuclei, enabling the characteristic differences in N/C ratio and nuclear distribution between normal, dysplastic, and cancerous oral mucosa to be quantified. This paper discusses the technical design and performance characteristics of these complementary imaging systems. We will also present data from ongoing clinical studies aimed at evaluating diagnostic performance of these systems for detection of oral neoplasia.

  13. NIR Imaging of the AKARI North Ecliptic Pole Wide Survey Field (United States)

    Im, Myungshin; Lee, Hyung Mok; Lee, Myung Gyoon; Matsuhara, Hideo; Wada, Takehiko; Oyabu, Shinki; Akari Nep Survey Team


    We propose to perform J- and H-band wide-field imaging of the north ecliptic pole (NEP) area which has been surveyed by the AKARI Infrared Space Telescope. The NEP-Wide survey, one of the AKARI's key scientific programs, images a 5.8 deg^2 circular area centered on the north ecliptic pole with contiguous 9 passbands between 2.5 and 24 (micron) to the flux limit ranging from 15 (mu)Jy to 500 (mu)Jy (plus FIR data), including 11, 15, and 18 (micron) bands where the Spitzer has limitations. Thus, NEP-Wide is the only wide-area IR survey that allows us to study the evolution of various mid-IR features from z=0 to z=2 such as PAHs, silicate absorptions, and power-slopes of AGNs, and their connection to IR-luminosity, star formation and AGN activities of IR sources not bright enough for the Spitzer spectroscopy. Optical imaging as well as radio/X-ray data exist over this field, however there is a gaping hole at NIR between the AKARI and the optical coverage. In order to fill the wavelength gap, we propose to obtain J-, and H-band images to 15 (mu)Jy at 5-σ using FLAMINGOS on the 2.1-m. Filling the hole in the spectral energy distribution will significantly increase the value of the NEP-Wide dataset by permitting us to add more accurate stellar mass and photo-z estimates, and also a large number of SEDs from optical to IR without a gap in wavelength coverage.

  14. Automatic detection of diabetic retinopathy features in ultra-wide field retinal images (United States)

    Levenkova, Anastasia; Sowmya, Arcot; Kalloniatis, Michael; Ly, Angelica; Ho, Arthur


    Diabetic retinopathy (DR) is a major cause of irreversible vision loss. DR screening relies on retinal clinical signs (features). Opportunities for computer-aided DR feature detection have emerged with the development of Ultra-WideField (UWF) digital scanning laser technology. UWF imaging covers 82% greater retinal area (200°), against 45° in conventional cameras3 , allowing more clinically relevant retinopathy to be detected4 . UWF images also provide a high resolution of 3078 x 2702 pixels. Currently DR screening uses 7 overlapping conventional fundus images, and the UWF images provide similar results1,4. However, in 40% of cases, more retinopathy was found outside the 7-field ETDRS) fields by UWF and in 10% of cases, retinopathy was reclassified as more severe4 . This is because UWF imaging allows examination of both the central retina and more peripheral regions, with the latter implicated in DR6 . We have developed an algorithm for automatic recognition of DR features, including bright (cotton wool spots and exudates) and dark lesions (microaneurysms and blot, dot and flame haemorrhages) in UWF images. The algorithm extracts features from grayscale (green "red-free" laser light) and colour-composite UWF images, including intensity, Histogram-of-Gradient and Local binary patterns. Pixel-based classification is performed with three different classifiers. The main contribution is the automatic detection of DR features in the peripheral retina. The method is evaluated by leave-one-out cross-validation on 25 UWF retinal images with 167 bright lesions, and 61 other images with 1089 dark lesions. The SVM classifier performs best with AUC of 94.4% / 95.31% for bright / dark lesions.

  15. Microlensing Surveys of M31 in the Wide Field Imaging ERA

    Energy Technology Data Exchange (ETDEWEB)

    Baltz, E.


    The Andromeda Galaxy (M31) is the closest large galaxy to the Milky Way, thus it is an important laboratory for studying massive dark objects in galactic halos (MACHOs) by gravitational microlensing. Such studies strongly complement the studies of the Milky Way halo using the Large and Small Magellanic Clouds. We consider the possibilities for microlensing surveys of M31 using the next generation of wide field imaging telescopes with fields of view in the square degree range. We consider proposals for such imagers both on the ground and in space. For concreteness, we specialize to the SNAP proposal for a space telescope and the LSST proposal for a ground based telescope. We find that a modest space-based survey of 50 visits of one hour each is considerably better than current ground based surveys covering 5 years. Crucially, systematic effects can be considerably better controlled with a space telescope because of both the infrared sensitivity and the angular resolution. To be competitive, 8 meter class wide-field ground based imagers must take exposures of several hundred seconds with several day cadence.

  16. Automatic Processing of Chinese GF-1 Wide Field of View Images (United States)

    Zhang, Y.; Wan, Y.; Wang, B.; Kang, Y.; Xiong, J.


    The wide field of view (WFV) imaging instrument carried on the Chinese GF-1 satellite includes four cameras. Each camera has 200km swath-width that can acquire earth image at the same time and the observation can be repeated within only 4 days. This enables the applications of remote sensing imagery to advance from non-scheduled land-observation to periodically land-monitoring in the areas that use the images in such resolutions. This paper introduces an automatic data analysing and processing technique for the wide-swath images acquired by GF-1 satellite. Firstly, the images are validated by a self-adaptive Gaussian mixture model based cloud detection method to confirm whether they are qualified and suitable to be involved into the automatic processing workflow. Then the ground control points (GCPs) are quickly and automatically matched from the public geo-information products such as the rectified panchromatic images of Landsat-8. Before the geometric correction, the cloud detection results are also used to eliminate the invalid GCPs distributed in the cloud covered areas, which obviously reduces the ratio of blunders of GCPs. The geometric correction module not only rectifies the rational function models (RFMs), but also provides the self-calibration model and parameters for the non-linear distortion, and it is iteratively processed to detect blunders. The maximum geometric distortion in WFV image decreases from about 10-15 pixels to 1-2 pixels when compensated by self-calibration model. The processing experiments involve hundreds of WFV images of GF-1 satellite acquired from June to September 2013, which covers the whole mainland of China. All the processing work can be finished by one operator within 2 days on a desktop computer made up by a second-generation Intel Core-i7 CPU and a 4-solid-State-Disk array. The digital ortho maps (DOM) are automatically generated with 3 arc second Shuttle Radar Topography Mission (SRTM). The geometric accuracies of the

  17. Wide-field mid-infrared hyperspectral imaging of adhesives using a bolometer camera. (United States)

    Sugawara, Shigeru; Nakayama, Yoshihiko; Taniguchi, Hideya; Ishimaru, Ichiro


    By combining a bolometer detector with an imaging-type interferometer, an inexpensive, easy-to-handle wide-field mid-infrared hyperspectral imaging apparatus was produced. We measured the distributions of four types of thin adhesive layers on an aluminium plate and analysed the results using correlation coefficients to visualise the distribution of various adhesives that cannot be discerned by the naked eye or conventional methods such as visible/near-infrared spectroscopic/fluorescent photography. The measurement wavelength range, obtained spectrum's wavenumber resolution, and measurement time was 8-14 μm, about 9 cm-1, and about 30 s, respectively. Using conventional methods, adhesives could not be distinguished from the others. By using this method, we found that adhesives could be precisely distinguished by setting an appropriate threshold value for the correlation coefficient. Thus, our approach can accurately measure the spatial distribution of different types of adhesive that cannot be discriminated by conventional methods.

  18. Wide-field fluorescent microscopy and fluorescent imaging flow cytometry on a cell-phone. (United States)

    Zhu, Hongying; Ozcan, Aydogan


    Fluorescent microscopy and flow cytometry are widely used tools in biomedical research and clinical diagnosis. However these devices are in general relatively bulky and costly, making them less effective in the resource limited settings. To potentially address these limitations, we have recently demonstrated the integration of wide-field fluorescent microscopy and imaging flow cytometry tools on cell-phones using compact, light-weight, and cost-effective opto-fluidic attachments. In our flow cytometry design, fluorescently labeled cells are flushed through a microfluidic channel that is positioned above the existing cell-phone camera unit. Battery powered light-emitting diodes (LEDs) are butt-coupled to the side of this microfluidic chip, which effectively acts as a multi-mode slab waveguide, where the excitation light is guided to uniformly excite the fluorescent targets. The cell-phone camera records a time lapse movie of the fluorescent cells flowing through the microfluidic channel, where the digital frames of this movie are processed to count the number of the labeled cells within the target solution of interest. Using a similar opto-fluidic design, we can also image these fluorescently labeled cells in static mode by e.g. sandwiching the fluorescent particles between two glass slides and capturing their fluorescent images using the cell-phone camera, which can achieve a spatial resolution of e.g. - 10 μm over a very large field-of-view of - 81 mm(2). This cell-phone based fluorescent imaging flow cytometry and microscopy platform might be useful especially in resource limited settings, for e.g. counting of CD4+ T cells toward monitoring of HIV+ patients or for detection of water-borne parasites in drinking water.

  19. Wide-field imaging through scattering media by scattered light fluorescence microscopy (United States)

    Zhou, Yulan; Li, Xun


    To obtain images through scattering media, scattered light fluorescence (SLF) microscopy that utilizes the optical memory effect has been developed. However, the small field of view (FOV) of SLF microscopy limits its application. In this paper, we have introduced a re-modulation method to achieve wide-field imaging through scattering media by SLF microscopy. In the re-modulation method, to raster scan the focus across the object plane, the incident wavefront is re-modulated via a spatial light modulator (SLM) in the updated phase compensation calculated using the optimized iterative algorithm. Compared with the conventional optical memory effect method, the re-modulation method can greatly increase the FOV of a SLF microscope. With the phase compensation theoretically calculated, the process of updating the phase compensation of a high speed SLM is fast. The re-modulation method does not increase the imaging time. The re-modulation method is, therefore, expected to make SLF microscopy have much wider applications in biology, medicine and physiology.

  20. Wide-field OCT imaging of oral lesions in vivo: quantification and classification (Conference Presentation) (United States)

    Raizada, Rashika; Lee, Anthony M. D.; Liu, Kelly Y.; MacAulay, Calum E.; Ng, Samson; Poh, Catherine F.; Lane, Pierre M.


    Worldwide, there are over 450,000 new cases of oral cancer reported each year. Late-stage diagnosis remains a significant factor responsible for its high mortality rate (>50%). In-vivo non-invasive rapid imaging techniques, that can visualise clinically significant changes in the oral mucosa, may improve the management of oral cancer. We present an analysis of features extracted from oral images obtained using our hand- held wide-field Optical Coherence Tomography (OCT) instrument. The images were analyzed for epithelial scattering, overall tissue scattering, and 3D basement membrane topology. The associations between these three features and disease state (benign, pre-cancer, or cancer), as measured by clinical assessment or pathology, were determined. While scattering coefficient has previously been shown to be sensitive to cancer and dysplasia, likely due to changes in nuclear and cellular density, the addition of basement membrane topology may increase diagnostic ability- as it is known that the presence of bulbous rete pegs in the basement membrane are characteristic of dysplasia. The resolution and field-of-view of our oral OCT system allowed analysis of these features over large areas of up to 2.5mm x 90mm, in a timely fashion, which allow for application in clinical settings.

  1. Wide-Field Imaging Telescope-0 (WIT0) with automatic observing system (United States)

    Ji, Tae-Geun; Byeon, Seoyeon; Lee, Hye-In; Park, Woojin; Lee, Sang-Yun; Hwang, Sungyong; Choi, Changsu; Gibson, Coyne Andrew; Kuehne, John W.; Prochaska, Travis; Marshall, Jennifer L.; Im, Myungshin; Pak, Soojong


    We introduce Wide-Field Imaging Telescope-0 (WIT0), with an automatic observing system. It is developed for monitoring the variabilities of many sources at a time, e.g. young stellar objects and active galactic nuclei. It can also find the locations of transient sources such as a supernova or gamma-ray bursts. In 2017 February, we installed the wide-field 10-inch telescope (Takahashi CCA-250) as a piggyback system on the 30-inch telescope at the McDonald Observatory in Texas, US. The 10-inch telescope has a 2.35 × 2.35 deg field-of-view with a 4k × 4k CCD Camera (FLI ML16803). To improve the observational efficiency of the system, we developed a new automatic observing software, KAOS30 (KHU Automatic Observing Software for McDonald 30-inch telescope), which was developed by Visual C++ on the basis of a windows operating system. The software consists of four control packages: the Telescope Control Package (TCP), the Data Acquisition Package (DAP), the Auto Focus Package (AFP), and the Script Mode Package (SMP). Since it also supports the instruments that are using the ASCOM driver, the additional hardware installations become quite simplified. We commissioned KAOS30 in 2017 August and are in the process of testing. Based on the WIT0 experiences, we will extend KAOS30 to control multiple telescopes in future projects.

  2. Automated segmentation of oral mucosa from wide-field OCT images (Conference Presentation) (United States)

    Goldan, Ryan N.; Lee, Anthony M. D.; Cahill, Lucas; Liu, Kelly; MacAulay, Calum; Poh, Catherine F.; Lane, Pierre


    Optical Coherence Tomography (OCT) can discriminate morphological tissue features important for oral cancer detection such as the presence or absence of basement membrane and epithelial thickness. We previously reported an OCT system employing a rotary-pullback catheter capable of in vivo, rapid, wide-field (up to 90 x 2.5mm2) imaging in the oral cavity. Due to the size and complexity of these OCT data sets, rapid automated image processing software that immediately displays important tissue features is required to facilitate prompt bed-side clinical decisions. We present an automated segmentation algorithm capable of detecting the epithelial surface and basement membrane in 3D OCT images of the oral cavity. The algorithm was trained using volumetric OCT data acquired in vivo from a variety of tissue types and histology-confirmed pathologies spanning normal through cancer (8 sites, 21 patients). The algorithm was validated using a second dataset of similar size and tissue diversity. We demonstrate application of the algorithm to an entire OCT volume to map epithelial thickness, and detection of the basement membrane, over the tissue surface. These maps may be clinically useful for delineating pre-surgical tumor margins, or for biopsy site guidance.

  3. Wide-field microscopic FRET imaging using simultaneous spectral unmixing of excitation and emission spectra. (United States)

    Du, Mengyan; Zhang, Lili; Xie, Shusen; Chen, Tongsheng


    Simultaneous spectral unmixing of excitation and emission spectra (ExEm unmixing) has the inherent ability to resolve donor emission, fluorescence resonance energy transfer (FRET)-sensitized acceptor emission and directly excited acceptor emission. We here develop an ExEm unmixing-based quantitative FRET measurement method (EES-FRET) independent of excitation intensity and detector parameter setting. The ratio factor (rK), predetermined using a donor-acceptor tandem construct, of total acceptor absorption to total donor absorption in excitation wavelengths used is introduced for determining the concentration ratio of acceptor to donor. We implemented EES-FRET method on a wide-field microscope to image living cells expressing tandem FRET constructs with different donor-acceptor stoichiometry.

  4. Wide field imaging spectrometer for ESA's future X-ray mission: XEUS

    CERN Document Server

    Strüder, L


    An active pixel sensor (APS) based on the DEpleted P-channel junction Field Effect Transistor (DEPFET) concept will be described as a potential wide field imager for ESA's high resolution, high throughput mission: 'X-ray Evolving Universe Spectroscopy' (XEUS). It comprises a parallel multichannel readout, low noise at high speed readout, backside illumination and a fill factor of 100% over the whole field of view. The depleted thickness will be 500 microns. These design parameters match the scientific requirements of the mission. The fabrication techniques of the DEPFET arrays are related to the high resistivity process of the X-ray pn-CCDs. Potential extensions of the already realized DEPFET structures are a non-destructive repetitive readout of the signal charges. This concept will be presented. As an alternative solution, frame store pn-CCDs are considered having the same format and pixel sizes as the proposed DEPFET arrays. Their development is a low risk, straightforward continuation of the XMM devices. ...

  5. Studies of prototype DEPFET sensors for the Wide Field Imager of Athena (United States)

    Treberspurg, Wolfgang; Andritschke, Robert; Bähr, Alexander; Behrens, Annika; Hauser, Günter; Lechner, Peter; Meidinger, Norbert; Müller-Seidlitz, Johannes; Treis, Johannes


    The Wide Field Imager (WFI) of ESA's next X-ray observatory Athena will combine a high count rate capability with a large field of view, both with state-of-the-art spectroscopic performance. To meet these demands, specific DEPFET active pixel detectors have been developed and operated. Due to the intrinsic amplification of detected signals they are best suited to achieve a high speed and low noise performance. Different fabrication technologies and transistor geometries have been implemented on a dedicated prototype production in the course of the development of the DEPFET sensors. The main modifications between the sensors concern the shape of the transistor gate - regarding the layout - and the thickness of the gate oxide - regarding the technology. To facilitate the fabrication and testing of the resulting variety of sensors the presented studies were carried out with 64×64 pixel detectors. The detector comprises a control ASIC (Switcher-A), a readout ASIC (VERITAS- 2) and the sensor. In this paper we give an overview on the evaluation of different prototype sensors. The most important results, which have been decisive for the identification of the optimal fabrication technology and transistor layout for subsequent sensor productions are summarized. It will be shown that the developments result in an excellent performance of spectroscopic X-ray DEPFETs with typical noise values below 2.5 ENC at 2.5 μs/row.

  6. Evaluation of illumination system uniformity for wide-field biomedical hyperspectral imaging (United States)

    Sawyer, Travis W.; Siri Luthman, A.; E Bohndiek, Sarah


    Hyperspectral imaging (HSI) systems collect both spatial (morphological) and spectral (chemical) information from a sample. HSI can provide sensitive analysis for biological and medical applications, for example, simultaneously measuring reflectance and fluorescence properties of a tissue, which together with structural information could improve early cancer detection and tumour characterisation. Illumination uniformity is a critical pre-condition for quantitative data extraction from an HSI system. Non-uniformity can cause glare, specular reflection and unwanted shading, which negatively impact statistical analysis procedures used to extract abundance of different chemical species. Here, we model and evaluate several illumination systems frequently used in wide-field biomedical imaging to test their potential for HSI. We use the software LightTools and FRED. The analysed systems include: a fibre ring light; a light emitting diode (LED) ring; and a diffuse scattering dome. Each system is characterised for spectral, spatial, and angular uniformity, as well as transfer efficiency. Furthermore, an approach to measure uniformity using the Kullback-Leibler divergence (KLD) is introduced. The KLD is generalisable to arbitrary illumination shapes, making it an attractive approach for characterising illumination distributions. Although the systems are quite comparable in their spatial and spectral uniformity, the most uniform angular distribution is achieved using a diffuse scattering dome, yielding a contrast of 0.503 and average deviation of 0.303 over a ±60° field of view with a 3.9% model error in the angular domain. Our results suggest that conventional illumination sources can be applied in HSI, but in the case of low light levels, bespoke illumination sources may offer improved performance.

  7. Wide field imager instrument for the Advanced Telescope for High Energy Astrophysics (United States)

    Meidinger, Norbert; Nandra, Kirpal; Plattner, Markus; Porro, Matteo; Rau, Arne; Santangelo, Andrea; Tenzer, Chris; Wilms, Jörn


    The Advanced Telescope for High Energy Astrophysics (Athena) has been selected for ESA's L2 mission, scheduled for launch in 2028. It will provide the necessary capabilities to achieve the ambitious goals of the science theme "The Hot and Energetic Universe." Athena's x-ray mirrors will be based on silicon pore optics technology with a 12-m focal length. Two complementary focal plane camera systems are foreseen, which can be moved interchangeably to the focus of the mirror system: the actively shielded micro-calorimeter spectrometer X-IFU and the wide field imager (WFI). The WFI camera will provide an unprecedented survey power through its large field of view of 40 arc min with a high count-rate capability (˜1 Crab). It permits a state-of-the-art energy resolution in the energy band of 0.1 to 15 keV during the entire mission lifetime (e.g., full width at half maximum ≤150 eV at 6 keV). This performance is accomplished by a set of depleted P-channel field effect transistor (DEPFET) active pixel sensor matrices with a pixel size well suited to the angular resolution of 5 arc sec (on-axis) of the mirror system. Each DEPFET pixel is a combined detector-amplifier structure with a MOSFET integrated onto a fully depleted 450-μm-thick silicon bulk. This manuscript will summarize the current instrument concept and design, the status of the technology development, and the envisaged baseline performance.

  8. VizieR Online Data Catalog: Wide field imagers ground-based astrometry. V. (Libralato+, 2014) (United States)

    Libralato, M.; Bellini, A.; Bedin, L. R.; Piotto, G.; Platais, I.; Kissler-Patig, M.; Milone, A. P.


    Astro-photometric catalogs of 7 different fields. For each field we provide equatorial and pixel coordinates, infrared wide-band photometry. For NGC 6656 and NGC 6121 we also provide proper motions and an estimate of the membership probability. (11 data files).

  9. Rapid wide-field Mueller matrix polarimetry imaging based on four photoelastic modulators with no moving parts. (United States)

    Alali, Sanaz; Gribble, Adam; Vitkin, I Alex


    A new polarimetry method is demonstrated to image the entire Mueller matrix of a turbid sample using four photoelastic modulators (PEMs) and a charge coupled device (CCD) camera, with no moving parts. Accurate wide-field imaging is enabled with a field-programmable gate array (FPGA) optical gating technique and an evolutionary algorithm (EA) that optimizes imaging times. This technique accurately and rapidly measured the Mueller matrices of air, polarization elements, and turbid phantoms. The system should prove advantageous for Mueller matrix analysis of turbid samples (e.g., biological tissues) over large fields of view, in less than a second.

  10. Wide field imaging - I. Applications of neural networks to object detection and star/galaxy classification (United States)

    Andreon, S.; Gargiulo, G.; Longo, G.; Tagliaferri, R.; Capuano, N.


    Astronomical wide-field imaging performed with new large-format CCD detectors poses data reduction problems of unprecedented scale, which are difficult to deal with using traditional interactive tools. We present here NExt (Neural Extractor), a new neural network (NN) based package capable of detecting objects and performing both deblending and star/galaxy classification in an automatic way. Traditionally, in astronomical images, objects are first distinguished from the noisy background by searching for sets of connected pixels having brightnesses above a given threshold; they are then classified as stars or as galaxies through diagnostic diagrams having variables chosen according to the astronomer's taste and experience. In the extraction step, assuming that images are well sampled, NExt requires only the simplest a priori definition of `what an object is' (i.e. it keeps all structures composed of more than one pixel) and performs the detection via an unsupervised NN, approaching detection as a clustering problem that has been thoroughly studied in the artificial intelligence literature. The first part of the NExt procedure consists of an optimal compression of the redundant information contained in the pixels via a mapping from pixel intensities to a subspace individualized through principal component analysis. At magnitudes fainter than the completeness limit, stars are usually almost indistinguishable from galaxies, and therefore the parameters characterizing the two classes do not lie in disconnected subspaces, thus preventing the use of unsupervised methods. We therefore adopted a supervised NN (i.e. a NN that first finds the rules to classify objects from examples and then applies them to the whole data set). In practice, each object is classified depending on its membership of the regions mapping the input feature space in the training set. In order to obtain an objective and reliable classification, instead of using an arbitrarily defined set of features

  11. Wide-field time-resolved luminescence imaging and spectroscopy to decipher obliterated documents in forensic science (United States)

    Suzuki, Mototsugu; Akiba, Norimitsu; Kurosawa, Kenji; Kuroki, Kenro; Akao, Yoshinori; Higashikawa, Yoshiyasu


    We applied a wide-field time-resolved luminescence (TRL) method with a pulsed laser and a gated intensified charge coupled device (ICCD) for deciphering obliterated documents for use in forensic science. The TRL method can nondestructively measure the dynamics of luminescence, including fluorescence and phosphorescence lifetimes, which prove to be useful parameters for image detection. First, we measured the TRL spectra of four brands of black porous-tip pen inks on paper to estimate their luminescence lifetimes. Next, we acquired the TRL images of 12 obliterated documents at various delay times and gate times of the ICCD. The obliterated contents were revealed in the TRL images because of the difference in the luminescence lifetimes of the inks. This method requires no pretreatment, is nondestructive, and has the advantage of wide-field imaging, which makes it is easy to control the gate timing. This demonstration proves that TRL imaging and spectroscopy are powerful tools for forensic document examination.

  12. Image Centroid Algorithms for Sun Sensors with Super Wide Field of View

    Directory of Open Access Journals (Sweden)

    ZHAN Yinhu


    Full Text Available Sun image centroid algorithm is one of the key technologies of celestial navigation using sun sensors, which directly determine the precision of the sensors. Due to the limitation of centroid algorithm for non-circular sun image of the sun sensor of large field of view, firstly, the ellipse fitting algorithm is proposed for solving elliptical or sub-elliptical sun images. Then the spherical circle fitting algorithm is put forward. Based on the projection model and distortion model of the camera, the spherical circle fitting algorithm is used to obtain the edge points of the sun in the object space, and then the centroid of the sun can be determined by fitting the edge points as a spherical circle. In order to estimate the precision of spherical circle fitting algorithm, the centroid of the sun should be projected back to the image space. Theoretically, the spherical circle fitting algorithm is no longer need to take into account the shape of the sun image, the algorithm is more precise. The results of practical sun images demonstrate that the ellipse fitting algorithm is more suitable for the sun image with 70°~80.3° half angle of view, and the mean precision is about 0.075 pixels; the spherical circle fitting algorithm is more suitable for the sun image with a half angle of view larger than 80.3°, and the mean precision is about 0.082 pixels.

  13. Lensfree Fluorescent On-Chip Imaging of Transgenic Caenorhabditis elegans Over an Ultra-Wide Field-of-View (United States)

    Ozcan, Aydogan


    We demonstrate lensfree on-chip fluorescent imaging of transgenic Caenorhabditis elegans (C. elegans) over an ultra-wide field-of-view (FOV) of e.g., >2–8 cm2 with a spatial resolution of ∼10µm. This is the first time that a lensfree on-chip platform has successfully imaged fluorescent C. elegans samples. In our wide-field lensfree imaging platform, the transgenic samples are excited using a prism interface from the side, where the pump light is rejected through total internal reflection occurring at the bottom facet of the substrate. The emitted fluorescent signal from C. elegans samples is then recorded on a large area opto-electronic sensor-array over an FOV of e.g., >2–8 cm2, without the use of any lenses, thin-film interference filters or mechanical scanners. Because fluorescent emission rapidly diverges, such lensfree fluorescent images recorded on a chip look blurred due to broad point-spread-function of our platform. To combat this resolution challenge, we use a compressive sampling algorithm to uniquely decode the recorded lensfree fluorescent patterns into higher resolution images, demonstrating ∼10 µm resolution. We tested the efficacy of this compressive decoding approach with different types of opto-electronic sensors to achieve a similar resolution level, independent of the imaging chip. We further demonstrate that this wide FOV lensfree fluorescent imaging platform can also perform sequential bright-field imaging of the same samples using partially-coherent lensfree digital in-line holography that is coupled from the top facet of the same prism used in fluorescent excitation. This unique combination permits ultra-wide field dual-mode imaging of C. elegans on a chip which could especially provide a useful tool for high-throughput screening applications in biomedical research. PMID:21253611

  14. AWARE Wide Field View (United States)


    RGB colors to the standard sRGB to allow spectrally consistent colors on monitors for viewing . Finally, the images from each sensor are corrected based ...on the exposure time used and the calibrated sensitivity of each image sensor, again based on the flat field calibration, to allow viewing of imagery...prediction is scaled based on available bandwidth and the computational resources of the cluster. In addition to the interface described in the

  15. Compressive hyperspectral time-resolved wide-field fluorescence lifetime imaging (United States)

    Pian, Qi; Yao, Ruoyang; Sinsuebphon, Nattawut; Intes, Xavier


    Spectrally resolved fluorescence lifetime imaging and spatial multiplexing have offered information content and collection-efficiency boosts in microscopy, but efficient implementations for macroscopic applications are still lacking. An imaging platform based on time-resolved structured light and hyperspectral single-pixel detection has been developed to perform quantitative macroscopic fluorescence lifetime imaging (MFLI) over a large field of view (FOV) and multiple spectral bands simultaneously. The system makes use of three digital micromirror device (DMD)-based spatial light modulators (SLMs) to generate spatial optical bases and reconstruct N by N images over 16 spectral channels with a time-resolved capability (∼40 ps temporal resolution) using fewer than N2 optical measurements. We demonstrate the potential of this new imaging platform by quantitatively imaging near-infrared (NIR) Förster resonance energy transfer (FRET) both in vitro and in vivo. The technique is well suited for quantitative hyperspectral lifetime imaging with a high sensitivity and paves the way for many important biomedical applications.

  16. Wide-field, full-field optical coherence microscopy for high-axial-resolution phase and amplitude imaging. (United States)

    Federici, Antoine; da Costa, Henrique S Gutierrez; Ogien, Jonas; Ellerbee, Audrey K; Dubois, Arnaud


    An original single-objective, full-field optical coherence microscopy system is reported that is capable of imaging both the phase and the amplitude of semi-transparent samples over a field of view of 17.5  mm×17.5  mm with an axial sectioning resolution of 1.5 μm. A special stack acquisition arrangement ensures optimal reachable imaging depth. Several phase-shifting interferometry algorithms for phase measurement with broadband light are compared theoretically and experimentally. Using the phase information, noninvasive depth-resolved topographic images of multilayer samples are produced to characterize each layer by measuring their defects and curvature with a nanometric scale precision. Using the amplitude information, tomographic images with a constant detection sensitivity of ∼80  dB through the entire field of view are obtained and applied to biological specimens.

  17. Multimodal wide-field two-photon excitation imaging: characterization of the technique for in vivo applications. (United States)

    Hwang, Jae Youn; Wachsmann-Hogiu, Sebastian; Ramanujan, V Krishnan; Nowatzyk, Andreas G; Koronyo, Yosef; Medina-Kauwe, Lali K; Gross, Zeev; Gray, Harry B; Farkas, Daniel L


    We report fast, non-scanning, wide-field two-photon fluorescence excitation with spectral and lifetime detection for in vivo biomedical applications. We determined the optical characteristics of the technique, developed a Gaussian flat-field correction method to reduce artifacts resulting from non-uniform excitation such that contrast is enhanced, and showed that it can be used for ex vivo and in vivo cellular-level imaging. Two applications were demonstrated: (i) ex vivo measurements of beta-amyloid plaques in retinas of transgenic mice, and (ii) in vivo imaging of sulfonated gallium(III) corroles injected into tumors. We demonstrate that wide-field two photon fluorescence excitation with flat-field correction provides more penetration depth as well as better contrast and axial resolution than the corresponding one-photon wide field excitation for the same dye. Importantly, when this technique is used together with spectral and fluorescence lifetime detection modules, it offers improved discrimination between fluorescence from molecules of interest and autofluorescence, with higher sensitivity and specificity for in vivo applications.

  18. Wide Field-of-View Fluorescence Imaging with Optical-Quality Curved Microfluidic Chamber for Absolute Cell Counting

    Directory of Open Access Journals (Sweden)

    Mohiuddin Khan Shourav


    Full Text Available Field curvature and other aberrations are encountered inevitably when designing a compact fluorescence imaging system with a simple lens. Although multiple lens elements can be used to correct most such aberrations, doing so increases system cost and complexity. Herein, we propose a wide field-of-view (FOV fluorescence imaging method with an unconventional optical-quality curved sample chamber that corrects the field curvature caused by a simple lens. Our optics simulations and proof-of-concept experiments demonstrate that a curved substrate with lens-dependent curvature can reduce greatly the distortion in an image taken with a conventional planar detector. Following the validation study, we designed a curved sample chamber that can contain a known amount of sample volume and fabricated it at reasonable cost using plastic injection molding. At a magnification factor of approximately 0.6, the curved chamber provides a clear view of approximately 119 mm2, which is approximately two times larger than the aberration-free area of a planar chamber. Remarkably, a fluorescence image of microbeads in the curved chamber exhibits almost uniform intensity over the entire field even with a simple lens imaging system, whereas the distorted boundary region has much lower brightness than the central area in the planar chamber. The absolute count of white blood cells stained with a fluorescence dye was in good agreement with that obtained by a commercially available conventional microscopy system. Hence, a wide FOV imaging system with the proposed curved sample chamber would enable us to acquire an undistorted image of a large sample volume without requiring a time-consuming scanning process in point-of-care diagnostic applications.

  19. SkICAT: A cataloging and analysis tool for wide field imaging surveys (United States)

    Weir, N.; Fayyad, U. M.; Djorgovski, S. G.; Roden, J.


    We describe an integrated system, SkICAT (Sky Image Cataloging and Analysis Tool), for the automated reduction and analysis of the Palomar Observatory-ST ScI Digitized Sky Survey. The Survey will consist of the complete digitization of the photographic Second Palomar Observatory Sky Survey (POSS-II) in three bands, comprising nearly three Terabytes of pixel data. SkICAT applies a combination of existing packages, including FOCAS for basic image detection and measurement and SAS for database management, as well as custom software, to the task of managing this wealth of data. One of the most novel aspects of the system is its method of object classification. Using state-of-theart machine learning classification techniques (GID3* and O-BTree), we have developed a powerful method for automatically distinguishing point sources from non-point sources and artifacts, achieving comparably accurate discrimination a full magnitude fainter than in previous Schmidt plate surveys. The learning algorithms produce decision trees for classification by examining instances of objects classified by eye on both plate and higher quality CCD data. The same techniques will be applied to perform higher-level object classification (e.g., of galaxy morphology) in the near future. Another key feature of the system is the facility to integrate the catalogs from multiple plates (and portions thereof) to construct a single catalog of uniform calibration and quality down to the faintest limits of the survey. SkICAT also provides a variety of data analysis and exploration tools for the scientific utilization of the resulting catalogs. We include initial results of applying this system to measure the counts and distribution of galaxies in two bands down to Bj is approximately 21 mag over an approximate 70 square degree multi-plate field from POSS-II. SkICAT is constructed in a modular and general fashion and should be readily adaptable to other large-scale imaging surveys.

  20. GravityCam: ground-based wide-field high-resolution imaging and high-speed photometry (United States)

    Dominik, Martin; Mackay, Craig; Steele, Iain; Snodgrass, Colin; Hirsch, Michael; Gråe Jørgensen, Uffe; Hundertmark, Markus; Rebolo, Rafael; Horne, Keith; Bridle, Sarah; Sicardy, Bruno; Bramich, Daniel; Alsubai, Khalid


    The image blurring by the Earth's atmosphere generally poses a substantial limitation to ground-based observations. While opportunities in space are scarce, lucky imaging can correct over a much larger patch of sky and with much fainter reference stars. We propose the first of a new kind of versatile instruments, "GravityCam", composed of ~100 EMCCDs, that will open up two entirely new windows to ground-based astronomy: (1) wide-field high-resolution imaging, and (2) wide-field high-speed photometry. Potential applications include (a) a gravitational microlensing survey going 4 magnitudes deeper than current efforts, and thereby gaining a factor 100 in mass at the same sensitivity, which means probing down to Lunar mass or even below, (b) extra-solar planet hunting via transits in galactic bulge fields, with high time resolution well-suited for transit timing variation studies, (c) variable stars in crowded fields, with sensitivity to very short periods, (d) asteroseismology with many bright stars in one pointing, (e) serendipitous occultations of stars by small solar system bodies, giving access to the small end of the Kuiper Belt size distribution and potentially leading to the first detection of true Oort cloud objects, while predicted occultations at high time resolution can reveal atmospheres, satellites, or rings, (f) general data mining of the high-speed variable sky (down to 40 ms cadence).

  1. Wide-field flexible endoscope for simultaneous color and NIR fluorescence image acquisition during surveillance colonoscopy (United States)

    García-Allende, P. Beatriz; Nagengast, Wouter B.; Glatz, Jürgen; Ntziachristos, Vasilis


    Colorectal cancer (CRC) is the third most common form of cancer and, despite recent declines in both incidence and mortality, it still remains the second leading cause of cancer-related deaths in the western world. Colonoscopy is the standard for detection and removal of premalignant lesions to prevent CRC. The major challenges that physicians face during surveillance colonoscopy are the high adenoma miss-rates and the lack of functional information to facilitate decision-making concerning which lesions to remove. Targeted imaging with NIR fluorescence would address these limitations. Tissue penetration is increased in the NIR range while the combination with targeted NIR fluorescent agents provides molecularly specific detection of cancer cells, i.e. a red-flag detection strategy that allows tumor imaging with optimal sensitivity and specificity. The development of a flexible endoscopic fluorescence imaging method that can be integrated with standard medical endoscopes and facilitates the clinical use of this potential is described in this work. A semi-disposable coherent fiber optic imaging bundle that is traditionally employed in the exploration of biliary and pancreatic ducts is proposed, since it is long and thin enough to be guided through the working channel of a traditional video colonoscope allowing visualization of proximal lesions in the colon. A custom developed zoom system magnifies the image of the proximal end of the imaging bundle to fill the dimensions of two cameras operating in parallel providing the simultaneous color and fluorescence video acquisition.

  2. Retinal changes detected by wide-field autofluorescence imaging of patients with primary rhegmatogenous retinal detachment

    DEFF Research Database (Denmark)

    Poulsen, Christina Døfler; Grauslund, Jakob; Peto, Tunde


    and 2 months follow-up and 59 had gradable images with characteristics studied in this part of the study. Exclusions were: poor images (n=8), major surgery or changes on fellow-eye (n=11), no baseline or 2-month image (n=7), re-detachment at 2-month follow-up (n=1) and eyes traumas (n=2). Retinal.......2 million inhabitants. Methods: A clinical prospective study of 99 eyes in 99 patients undergoing surgery for primary RRD between 1st of January 2013 and 12th of July 2013. All patients underwent surgery with pars plana vitrectomy (PPV) and had either gas or silicone oil tamponade. Patients were examined...... eye history (including cataract surgery), present symptoms, IOP, time from RRD to surgery, preoperative proliferative vitreoretinopathy (PVR) graded according to standardized protocol as follows: A (vitreous haze, pigment, vitreous cells and clumps) , B (wrinkling of inner retinal suface, vessel...

  3. Real-time in vitro Fourier ptychographic microscopy for high resolution wide field of view phase imaging

    CERN Document Server

    Tian, Lei; Yeh, Li-Hao; Chen, Michael; Waller, Laura


    For centuries, microscopes have had to trade field of view (FOV) for resolution. Recently, a new computational imaging technique, termed Fourier ptychographic microscopy (FPM), circumvents this limit in order to capture gigapixel-scale images having both wide FOV and high resolution. FPM has enormous potential for revolutionizing biomedical microscopy; however, it has until now been limited to fixed samples, since acquisition time is on the order of minutes. Live biological samples are continuously evolving on multiple spatial and temporal scales, which can cause motion blur. Here, we present a Fast FPM method to achieve sub-second capture times for FPM results with 0.8 NA resolution across a 4x objective's FOV. We demonstrate the first FPM quantitative phase results for both growing and confluent in vitro cell cultures. Experiments capture real-time videos of HeLa and human mammary epithelial (MCF10A) cell division and migration and subcellular dynamical phenomena in adult rat neural stem cells.

  4. Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions. (United States)

    Polans, James; Keller, Brenton; Carrasco-Zevallos, Oscar M; LaRocca, Francesco; Cole, Elijah; Whitson, Heather E; Lad, Eleonora M; Farsiu, Sina; Izatt, Joseph A


    The peripheral retina of the human eye offers a unique opportunity for assessment and monitoring of ocular diseases. We have developed a novel wide-field (>70°) optical coherence tomography system (WF-OCT) equipped with wavefront sensorless adaptive optics (WSAO) for enhancing the visualization of smaller (23°) retina. We demonstrated the ability of our WF-OCT system to acquire non wavefront-corrected wide-field images rapidly, which could then be used to locate regions of interest, zoom into targeted features, and visualize the same region at different time points. A pilot clinical study was conducted on seven healthy volunteers and two subjects with prodromal Alzheimer's disease which illustrated the capability to image Drusen-like pathologies as far as 32.5° from the fovea in un-averaged volume scans. This work suggests that the proposed combination of WF-OCT and WSAO may find applications in the diagnosis and treatment of ocular, and potentially neurodegenerative, diseases of the peripheral retina, including diabetes and Alzheimer's disease.

  5. Optically sectioned wide-field fluorescence lifetime imaging microscopy enabled by structured illumination (United States)

    Hinsdale, Taylor; Olsovsky, Cory; Rico-Jimenez, Jose J.; Maitland, Kristen C.; Jo, Javier A.; Malik, Bilal H.


    In this paper, we demonstrate the ability of structured illumination microscopy to enhance the ability of fluorescence lifetime imaging to resolve fluorescence lifetimes in relatively thick samples that possess distinct but spectrally overlapping fluorescent layers. Structured illumination fluorescent lifetime imaging microscopy (SI-FLIM) is shown to be able to accurately reconstruct lifetime values in homogenous fluorophore samples (POPOP, NADH, and FAD) as well as accurately measure fluorescent lifetime in two layer models that are layered with NADH/FAD over POPOP, where NADH/FAD and POPOP have spectral overlap. Finally, the ability of SI-FLIM was demonstrated in a hamster cheek pouch ex vivo to show that more accurate lifetimes could be measured for each layer of interest in the oral mucosa (epithelium and submucosa). PMID:28663841

  6. Light-pollution measurement with the Wide-field all-sky image analyzing monitoring system (United States)

    Vítek, S.


    The purpose of this experiment was to measure light pollution in the capital of Czech Republic, Prague. As a measuring instrument is used calibrated consumer level digital single reflex camera with IR cut filter, therefore, the paper reports results of measuring and monitoring of the light pollution in the wavelength range of 390 - 700 nm, which most affects visual range astronomy. Combining frames of different exposure times made with a digital camera coupled with fish-eye lens allow to create high dynamic range images, contain meaningful values, so such a system can provide absolute values of the sky brightness.

  7. Development of digital system for the wide-field x-ray imaging detector aboard Kanazawa-SAT3 (United States)

    Kagawa, Yasuaki; Yonetoku, Daisuke; Sawano, Tatsuya; Mihara, Tatehiro; Kyutoku, Koutarou; Ikeda, Hirokazu; Yoshida, Kazuki; Ina, Masao; Ota, Kaichi; Suzuki, Daichi; Miyao, Kouga; Watanabe, Syouta; Hatori, Satoshi; Kume, Kyo; Mizushima, Satoshi; Hasegawa, Takashi


    We are planning to launch a micro satellite, Kanazawa-SAT3 , at the end of FY2018 to localize X-ray transients associated with gravitational wave sources. Now we are testing a prototype model of wide-field Xray imaging detector named T-LEX (Transient Localization EXperiment). T-LEX is an orthogonally distributed two sets of 1-dimensional silicon strip detectors with coded aperture masks, and covers more than 1 steradian field of view in the energy range of 1 - 20 keV. Each dimension has 512 readout electrodes (totally 1,024 channels), and they are read out with application specific integrated circuits (ASICs) controlled by two onboard FPGAs. Moreover, each FPGA calculates the cross correlation between the X-ray intensity and mask patterns every 64 msec, makes a histogram of lightcurves and energy spectra, and also plays a role of telemetry/command interface to mission CPU. In this paper, we report an overview of digital electronics system. Especially, we focus on the high-speed imaging processor on FPGA and demonstrate its performance as an X-ray imaging system.

  8. Wide-field spectral imaging of human ovary autofluorescence and oncologic diagnosis via previously collected probe data (United States)

    Renkoski, Timothy E.; Hatch, Kenneth D.; Utzinger, Urs


    With no sufficient screening test for ovarian cancer, a method to evaluate the ovarian disease state quickly and nondestructively is needed. The authors have applied a wide-field spectral imager to freshly resected ovaries of 30 human patients in a study believed to be the first of its magnitude. Endogenous fluorescence was excited with 365-nm light and imaged in eight emission bands collectively covering the 400- to 640-nm range. Linear discriminant analysis was used to classify all image pixels and generate diagnostic maps of the ovaries. Training the classifier with previously collected single-point autofluorescence measurements of a spectroscopic probe enabled this novel classification. The process by which probe-collected spectra were transformed for comparison with imager spectra is described. Sensitivity of 100% and specificity of 51% were obtained in classifying normal and cancerous ovaries using autofluorescence data alone. Specificity increased to 69% when autofluorescence data were divided by green reflectance data to correct for spatial variation in tissue absorption properties. Benign neoplasm ovaries were also found to classify as nonmalignant using the same algorithm. Although applied ex vivo, the method described here appears useful for quick assessment of cancer presence in the human ovary.

  9. Gradient Permittivity Meta-Structure model for Wide-field Super-resolution imaging with a sub-45 nm resolution. (United States)

    Cao, Shun; Wang, Taisheng; Xu, Wenbin; Liu, Hua; Zhang, Hongxin; Hu, Bingliang; Yu, Weixing


    A gradient permittivity meta-structure (GPMS) model and its application in super-resolution imaging were proposed and discussed in this work. The proposed GPMS consists of alternate metallic and dielectric films with a gradient permittivity which can support surface plasmons (SPs) standing wave interference patterns with a super resolution. By employing the rigorous numerical FDTD simulation method, the GPMS was carefully simulated to find that the period of the SPs interference pattern is only 84 nm for a 532 nm incident light. Furthermore, the potential application of the GPMS for wide-field super-resolution imaging was also discussed and the simulation results show that an imaging resolution of sub-45 nm can be achieved based on the plasmonic structure illumination microscopic method, which means a 5.3-fold improvement on resolution has been achieved in comparison with conventional epifluorescence microscopy. Moreover, besides the super-resolution imaging application, the proposed GPMS model can also be applied for nanolithography and other areas where super resolution patterns are needed.

  10. Portable lensless wide-field microscopy imaging platform based on digital inline holography and multi-frame pixel super-resolution

    National Research Council Canada - National Science Library

    Antonio C Sobieranski; Fatih Inci; H Cumhur Tekin; Mehmet Yuksekkaya; Eros Comunello; Daniel Cobra; Aldo Von Wangenheim; Utkan Demirci


      In this paper, an irregular displacement-based lensless wide-field microscopy imaging platform is presented by combining digital in-line holography and computational pixel super-resolution using multi-frame processing...

  11. Comparison of multispectral wide-field optical imaging modalities to maximize image contrast for objective discrimination of oral neoplasia (United States)

    Roblyer, Darren; Kurachi, Cristina; Stepanek, Vanda; Schwarz, Richard A.; Williams, Michelle D.; El-Naggar, Adel K.; Lee, J. Jack; Gillenwater, Ann M.; Richards-Kortum, Rebecca


    Multispectral widefield optical imaging has the potential to improve early detection of oral cancer. The appropriate selection of illumination and collection conditions is required to maximize diagnostic ability. The goals of this study were to (i) evaluate image contrast between oral cancer/precancer and non-neoplastic mucosa for a variety of imaging modalities and illumination/collection conditions, and (ii) use classification algorithms to evaluate and compare the diagnostic utility of these modalities to discriminate cancers and precancers from normal tissue. Narrowband reflectance, autofluorescence, and polarized reflectance images were obtained from 61 patients and 11 normal volunteers. Image contrast was compared to identify modalities and conditions yielding greatest contrast. Image features were extracted and used to train and evaluate classification algorithms to discriminate tissue as non-neoplastic, dysplastic, or cancer; results were compared to histologic diagnosis. Autofluorescence imaging at 405-nm excitation provided the greatest image contrast, and the ratio of red-to-green fluorescence intensity computed from these images provided the best classification of dysplasia/cancer versus non-neoplastic tissue. A sensitivity of 100% and a specificity of 85% were achieved in the validation set. Multispectral widefield images can accurately distinguish neoplastic and non-neoplastic tissue; however, the ability to separate precancerous lesions from cancers with this technique was limited.

  12. Mapping the Tidal Destruction of the Hercules Dwarf: A Wide-field DECam Imaging Search for RR Lyrae Stars (United States)

    Garling, Christopher; Willman, Beth; Sand, David J.; Hargis, Jonathan; Crnojević, Denija; Bechtol, Keith; Carlin, Jeffrey L.; Strader, Jay; Zou, Hu; Zhou, Xu; Nie, Jundan; Zhang, Tianmeng; Zhou, Zhimin; Peng, Xiyan


    We investigate the hypothesized tidal disruption of the Hercules ultra-faint dwarf galaxy (UFD). Previous tidal disruption studies of the Hercules UFD have been hindered by the high degree of foreground contamination in the direction of the dwarf. We bypass this issue by using RR Lyrae stars, which are standard candles with a very low field-volume density at the distance of Hercules. We use wide-field imaging from the Dark Energy Camera on CTIO to identify candidate RR Lyrae stars, supplemented with observations taken in coordination with the Beijing–Arizona Sky Survey on the Bok Telescope. Combining color, magnitude, and light-curve information, we identify three new RR Lyrae stars associated with Hercules. All three of these new RR Lyrae stars lie outside its published tidal radius. When considered with the nine RR Lyrae stars already known within the tidal radius, these results suggest that a substantial fraction of Hercules’ stellar content has been stripped. With this degree of tidal disruption, Hercules is an interesting case between a visibly disrupted dwarf (such as the Sagittarius dwarf spheroidal galaxy) and one in dynamic equilibrium. The degree of disruption also shows that we must be more careful with the ways we determine object membership when estimating dwarf masses in the future. One of the three discovered RR Lyrae stars sits along the minor axis of Hercules, but over two tidal radii away. This type of debris is consistent with recent models that suggest Hercules’ orbit is aligned with its minor axis.

  13. Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins (United States)

    Nichols, Brandon S.; Llopis, Antonio; Palmer, Gregory M.; McCachren, Samuel S., III; Senlik, Ozlem; Miller, David; Brooke, Martin A.; Jokerst, Nan M.; Geradts, Joseph; Greenup, Rachel; Ramanujam, Nimmi


    We have developed a portable, breast margin assessment probe leveraging diffuse optical spectroscopy to quantify the morphological landscape of breast tumor margins during breast conserving surgery. The approach presented here leverages a custom-made 16-channel annular photodiode imaging array (arranged in a 4×4 grid), a raster-scanning imaging platform with precision pressure control, and compressive sensing with an optimized set of eight wavelengths in the visible spectral range. A scalable Monte-Carlo-based inverse model is used to generate optical property [μs‧(λ) and μa(λ)] measures for each of the 16 simultaneously captured diffuse reflectance spectra. Subpixel sampling (0.75 mm) is achieved through incremental x, y raster scanning of the imaging probe, providing detailed optical parameter maps of breast margins over a 2×2 cm2 area in ˜9 min. The morphological landscape of a tumor margin is characterized using optical surrogates for the fat to fibroglandular content ratio, which has demonstrated diagnostic utility in delineating tissue subtypes in the breast.

  14. ProtoEXIST2: Advanced Wide-field Imaging CZT Detector Development For The HET On The Proposed EXIST Mission (United States)

    Hong, JaeSub; Allen, B.; Grindlay, J.; Barthelmy, S.; Baker, R.; Gehrels, N.; Cook, W.; Kaye, S.; Harrison, F.


    We describe our development of ProtoEXIST2, the advanced CZT imaging detector and wide field telescope prototype for the High Energy Telescope (HET) on the proposed Energetic X-ray Imaging Survey Telescope (EXIST) mission. EXIST is a multi-wavelength Medium class mission which would explore the early Universe using high redshift Gamma-ray Bursts and survey black holes on all scales. ProtoEXIST2 will demonstrate the feasibility of a large scale imaging module (256 cm2) with a close-tiled array of fine pixel (0.6 mm) CZT with a balloon flight test in 2010 or 2011. This second generation close-tiled CZT imager follows ProtoEXIST1, which had a recent successful balloon flight (see Allen et al in this meeting) using the same area CZT detector module (256 cm2) but with larger pixel size (2.5mm). For signal readout and event processing, we use the Direct-Bond (DB) ASIC, developed for the NuSTAR mission to be used in a close-tiled 2 x 2 array of 2x2 cm2 CZT detectors, each with 32x32 pixels. The DB-ASIC is attractive for a large scale implementation of tiled imaging CZT detectors given its low noise and power consumption (70uW/pixel). We are developing readout for the DB-ASIC that incorporates our back-end FPGA readout architecture developed for ProtoEXIST1 in order to accomplish the 256 cm2 detector module area with totally vertical integration (i.e. no auxialliary boards to the sides of the module. This is required to tile large numbers of modules into the very large total area (4.5m^2) proposed for the HET on EXIST. We review the design of the EXIST/HET and its optimum shielding in light of our ProtoEXIST1 balloon flight and our plan for future development of ProtoEXIST3, a final EXIST/HET detector module that would incorporate a still lower power version of the DB ASIC.

  15. Outcome of universal newborn eye screening with wide-field digital retinal image acquisition system: a pilot study. (United States)

    Goyal, P; Padhi, T R; Das, T; Pradhan, L; Sutar, S; Butola, S; Behera, U C; Jain, L; Jalali, S


    PurposeTo evaluate the outcome of universal newborn eye screening with wide-field digital retinal imaging (WFDRI) system.MethodsIn this pilot study, we examined 1152 apparently healthy newborn infants in the obstetrics and gynecology ward of a civil hospital in Eastern India over 1.5 years. The examination included external eye examination, red reflex test and fundus imaging by WFDRI (RetCam II, Clarity medical system, Pleasanton, CA, USA) by a trained optometrist. The pathologies detected, net monetary gain and skilled manpower saved were documented. The results were compared with three similar studies thus far published in the literature.ResultsOcular abnormality of any kind was seen in 172 (14.93%) babies. Retinal hemorrhage in 153 babies (88.9% of all abnormal findings) was the most common abnormality; it was bilateral in 118 (77.12%) babies and 4 babies had foveal hemorrhage. Other abnormalities included vitreous hemorrhage (n=1), congenital glaucoma (n=2), uveal coloboma (n=2), retinopathy mimicking retinopathy of prematurity (n=2), and cystic fovea (n=3). The retinal hemorrhages resolved spontaneously in all eyes. One baby with congenital glaucoma received surgery and the other was treated medically. The benefits included savings in skilled manpower, a net monetary gain of INR 4.195 million (US$ 62,612) and skilled manpower saving by 319.4 h.ConclusionsThe universal neonatal eye screening using WFDRI detected pathologies that needed immediate care or regular follow up; saved skilled manpower with a net monetary gain. But compared to a red reflex test the benefits were marginal in terms of detecting treatment warranting ocular pathologies.Eye advance online publication, 24 July 2017; doi:10.1038/eye.2017.129.

  16. Argus+: The Future of Wide-Field, Spectral-Line Imaging at 3-mm with the Green Bank Telescope (United States)

    Maddalena, Ronald; Frayer, David; Lockman, Felix; O'Neil, Karen; White, Steven; Argus+ Collaboration


    The Robert C Byrd Green Bank Telescope has met its design goal of providing high-quality observations at 115 GHz. Observers also have access to the new, 16-pixel, 3-mm Argus receiver, which is providing high-dynamic range images over wide fields for the multitude of spectral lines between 85 and 115 GHz, including CO, 13CO, C18O, SiO, HCN, HCO+, HNC, N2H+, and CS. The small number of pixels in Argus limits its ability to map many of the most interesting objects whose extent exceeds many arc-minutes. The successful performance of Argus, and its modular design, demonstrates that receivers with many more pixels could be built for the GBT. A 12 x 12 array of the Argus design would have mapping speeds about nine times faster than Argus without suffering any degradation in performance for the outer pixels in the array. We present our plans to build the next-generation Argus instrument (Argus+) with 144-pixels, a footprint 5’x5’, and 7" resolution at 110 GHz. The project will be a collaboration between the Green Bank Observatory and university groups, who will supply key components. The key science drivers for Argus+ are studies of molecular filaments in the Milky Way, studies of molecular clouds in nearby galaxies, and the observations of rapidly evolving solar system objects.

  17. Gemini Frontier Fields: Wide-field Adaptive Optics Ks-band Imaging of the Galaxy Clusters MACS J0416.1-2403 and Abell 2744 (United States)

    Schirmer, M.; Carrasco, E. R.; Pessev, P.; Garrel, V.; Winge, C.; Neichel, B.; Vidal, F.


    We have observed two of the six Frontier Fields galaxy clusters, MACS J0416.1-2403 and Abell 2744, using the Gemini Multi-Conjugate Adaptive Optics System (GeMS) and the Gemini South Adaptive Optics Imager (GSAOI). With 0.″ 08-0.″ 10 FWHM our data are nearly diffraction-limited over a 100\\prime\\prime × 100\\prime\\prime wide area. GeMS/GSAOI complements the Hubble Space Telescope (HST) redwards of 1.6 μm with twice the angular resolution. We reach a 5σ depth of {{K}s}˜ 25.6 mag (AB) for compact sources. In this paper, we describe the observations, data processing, and initial public data release. We provide fully calibrated, co-added images matching the native GSAOI pixel scale as well as the larger plate scales of the HST release, adding to the legacy value of the Frontier Fields. Our work demonstrates that even for fields at high galactic latitude where natural guide stars are rare, current multi-conjugated adaptive optics technology at 8 m telescopes has opened a new window on the distant universe. Observations of a third Frontier Field, Abell 370, are planned. Based on observations obtained at the Gemini Observatory, which is operated by the Association of Universities for Research in Astronomy, Inc., under a cooperative agreement with the NSF on behalf of the Gemini partnership: the National Science Foundation (United States), the Science and Technology Facilities Council (United Kingdom), the National Research Council (Canada), CONICYT (Chile), the Australian Research Council (Australia), Ministério da Ciência, Tecnologia e Inovação (Brazil) and Ministerio de Ciencia, Tecnología e Innovación Productiva (Argentina). Based on observations made with ESO Telescopes at the La Silla and Paranal Observatories, Chile.

  18. Wide-Field Plate Database (United States)

    Tsvetkov, M. K.; Stavrev, K. Y.; Tsvetkova, K. P.; Semkov, E. H.; Mutatov, A. S.

    The Wide-Field Plate Database (WFPDB) and the possibilities for its application as a research tool in observational astronomy are presented. Currently the WFPDB comprises the descriptive data for 400 000 archival wide field photographic plates obtained with 77 instruments, from a total of 1 850 000 photographs stored in 269 astronomical archives all over the world since the end of last century. The WFPDB is already accessible for the astronomical community, now only in batch mode through user requests sent by e-mail. We are working on on-line interactive access to the data via INTERNET from Sofia and parallel from the Centre de Donnees Astronomiques de Strasbourg. (Initial information can be found on World Wide Web homepage URL The WFPDB may be useful in studies of a variety of astronomical objects and phenomena, andespecially for long-term investigations of variable objects and for multi-wavelength research. We have analysed the data in the WFPDB in order to derive the overall characteristics of the totality of wide-field observations, such as the sky coverage, the distributions by observation time and date, by spectral band, and by object type. We have also examined the totality of wide-field observations from point of view of their quality, availability and digitisation. The usefulness of the WFPDB is demonstrated by the results of identification and investigation of the photometrical behaviour of optical analogues of gamma-ray bursts.

  19. Wide-field color imaging of scatter-based tissue contrast using both high spatial frequency illumination and cross-polarization gating. (United States)

    Carlson, Mackenzie L; McClatchy, David M; Gunn, Jason R; Elliott, Jonathan T; Paulsen, Keith D; Kanick, Stephen C; Pogue, Brian W


    This study characterizes the scatter-specific tissue contrast that can be obtained by high spatial frequency (HSF) domain imaging and cross-polarization (CP) imaging, using a standard color imaging system, and how combining them may be beneficial. Both HSF and CP approaches are known to modulate the sensitivity of epi-illumination reflectance images between diffuse multiply scattered and superficially backscattered photons, providing enhanced contrast from microstructure and composition than what is achieved by standard wide-field imaging. Measurements in tissue-simulating optical phantoms show that CP imaging returns localized assessments of both scattering and absorption effects, while HSF has uniquely specific sensitivity to scatter-only contrast, with a strong suppression of visible contrast from blood. The combination of CP and HSF imaging provided an expanded sensitivity to scatter compared with CP imaging, while rejecting specular reflections detected by HSF imaging. ex vivo imaging of an atlas of dissected rodent organs/tissues demonstrated the scatter-based contrast achieved with HSF, CP and HSF-CP imaging, with the white light spectral signal returned by each approach translated to a color image for intuitive encoding of scatter-based contrast within images of tissue. The results suggest that visible CP-HSF imaging could have the potential to aid diagnostic imaging of lesions in skin or mucosal tissues and organs, where just CP is currently the standard practice imaging modality. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. The Ooty Wide Field Array

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Astrophysics and Astronomy; Volume 38; Issue 1. The Ooty Wide Field Array. C. R. Subrahmanya P. K. Manoharan Jayaram N. Chengalur. Review Article Volume 38 Issue 1 March 2017 Article ID ... Keywords. Cosmology: large scale structure of Universe; intergalactic medium; diffuse radiation.

  1. Low-frequency wide-field fluorescence lifetime imaging using a high-power near-infrared light-emitting diode light source


    Gioux, Sylvain; Lomnes, Stephen J.; Choi, Hak Soo; Frangioni, John V.


    Fluorescence lifetime imaging (FLi) could potentially improve exogenous near-infrared (NIR) fluorescence imaging, because it offers the capability of discriminating a signal of interest from background, provides real-time monitoring of a chemical environment, and permits the use of several different fluorescent dyes having the same emission wavelength. We present a high-power, LED-based, NIR light source for the clinical translation of wide-field (larger than 5 cm in diameter) FLi at frequenc...

  2. The LOFT wide field monitor

    DEFF Research Database (Denmark)

    Brandt, Søren; Hernanz, M.; Alvarez, L.


    be able to address fundamental questions about strong gravity in the vicinity of black holes and the equation of state of nuclear matter in neutron stars. The prime goal of the WFM will be to detect transient sources to be observed by the LAD. However, with its wide field of view and good energy...... to the community of ~100 gamma ray burst positions per year with a ~1 arcmin location accuracy within 30 s of the burst. This paper provides an overview of the design, configuration, and capabilities of the LOFT WFM instrument....

  3. The FLARE mission: deep and wide-field 1-5um imaging and spectroscopy for the early universe: a proposal for M5 cosmic vision call (United States)

    Burgarella, D.; Levacher, P.; Vives, S.; Dohlen, K.; Pascal, S.


    FLARE (First Light And Reionization Explorer) is a space mission that will be submitted to ESA (M5 call). Its primary goal (~80% of lifetime) is to identify and study the universe before the end of the reionization at z > 6. A secondary objective (~20% of lifetime) is to survey star formation in the Milky Way. FLARE's strategy optimizes the science return: imaging and spectroscopic integral-field observations will be carried out simultaneously on two parallel focal planes and over very wide instantaneous fields of view. FLARE will help addressing two of ESA's Cosmic Vision themes: a) universe originate and what is it made of? » and b) « What are the conditions for planet formation and the emergence of life? >> and more specifically, >. FLARE will provide to the ESA community a leading position to statistically study the early universe after JWST's deep but pin-hole surveys. Moreover, the instrumental development of wide-field imaging and wide-field integral-field spectroscopy in space will be a major breakthrough after making them available on ground-based telescopes.

  4. Deep wide-field imaging down to the oldest main sequence turn-offs in the Sculptor dwarf spheroidal galaxy (United States)

    de Boer, T. J. L.; Tolstoy, E.; Saha, A.; Olsen, K.; Irwin, M. J.; Battaglia, G.; Hill, V.; Shetrone, M. D.; Fiorentino, G.; Cole, A.


    We present wide-field photometry of resolved stars in the nearby Sculptor dwarf spheroidal galaxy using CTIO/MOSAIC, going down to the oldest main sequence turn-off. The accurately flux calibrated wide field colour-magnitude diagrams can be used to constrain the ages of different stellar populations, and also their spatial distribution. The Sculptor dSph contains a predominantly ancient stellar population (>10 Gyr old) which can be easily resolved into individual stars. A galaxy dominated by an old population provides a clear view of ancient processes of galaxy formation unimpeded by overlying younger populations. By using spectroscopic metallicities of RGB stars in combination with our deep main sequence turn-off photometry we can constrain the ages of different stellar populations with particular accuracy. We find that the known metallicity gradient in Sculptor is well matched to an age gradient. This is the first time that this link with age has been directly quantified. This gradient has been previously observed as a variation in horizontal branch properties and is now confirmed to exist for main sequence turn-offs as well. It is likely the Sculptor dSph first formed an extended metal-poor population at the oldest times, and subsequent more metal-rich, younger stars were formed more towards the centre until the gas was depleted or lost roughly 7 Gyr ago. The fact that these clear radial gradients have been preserved up to the present day is consistent with the apparent lack of signs of recent tidal interactions. Appendices are only available in electronic form at

  5. Wide-field-of-view phase-contrast imaging of nanostructures with a comparatively large polychromatic soft x-ray plasma source. (United States)

    Gasilov, S V; Faenov, A Ya; Pikuz, T A; Fukuda, Y; Kando, M; Kawachi, T; Skobelev, I Yu; Daido, H; Kato, Y; Bulanov, S V


    Polychromatic soft x-ray plasma sources were not previously considered to be among the sources suitable for the propagation based phase contrast imaging because of their comparatively large emission-zone size. In the current work a scheme based on the combination of soft x-ray emission of multicharged ions, generated by the interaction of femtosecond laser pulses with an ultrasonic jet of gas clusters, and an LiF crystal detector was used to obtain phase-enhanced high-resolution images of micro- and nanoscale objects in a wide field of view.

  6. An automated wide-field time-gated optically sectioning fluorescence lifetime imaging multiwell plate reader for high-content analysis of protein-protein interactions (United States)

    Alibhai, Dominic; Kumar, Sunil; Kelly, Douglas; Warren, Sean; Alexandrov, Yuriy; Munro, Ian; McGinty, James; Talbot, Clifford; Murray, Edward J.; Stuhmeier, Frank; Neil, Mark A. A.; Dunsby, Chris; French, Paul M. W.


    We describe an optically-sectioned FLIM multiwell plate reader that combines Nipkow microscopy with wide-field time-gated FLIM, and its application to high content analysis of FRET. The system acquires sectioned FLIM images in protein. It has been applied to study the formation of immature HIV virus like particles (VLPs) in live cells by monitoring Gag-Gag protein interactions using FLIM FRET of HIV-1 Gag transfected with CFP or YFP. VLP formation results in FRET between closely packed Gag proteins, as confirmed by our FLIM analysis that includes automatic image segmentation.

  7. Challenges and advantages in wide-field optical coherence tomography angiography imaging of the human retinal and choroidal vasculature at 1.7-MHz A-scan rate (United States)

    Poddar, Raju; Migacz, Justin V.; Schwartz, Daniel M.; Werner, John S.; Gorczynska, Iwona


    We present noninvasive, three-dimensional, depth-resolved imaging of human retinal and choroidal blood circulation with a swept-source optical coherence tomography (OCT) system at 1065-nm center wavelength. Motion contrast OCT imaging was performed with the phase-variance OCT angiography method. A Fourier-domain mode-locked light source was used to enable an imaging rate of 1.7 MHz. We experimentally demonstrate the challenges and advantages of wide-field OCT angiography (OCTA). In the discussion, we consider acquisition time, scanning area, scanning density, and their influence on visualization of selected features of the retinal and choroidal vascular networks. The OCTA imaging was performed with a field of view of 16 deg (5 mm×5 mm) and 30 deg (9 mm×9 mm). Data were presented in en face projections generated from single volumes and in en face projection mosaics generated from up to 4 datasets. OCTA imaging at 1.7 MHz A-scan rate was compared with results obtained from a commercial OCTA instrument and with conventional ophthalmic diagnostic methods: fundus photography, fluorescein, and indocyanine green angiography. Comparison of images obtained from all methods is demonstrated using the same eye of a healthy volunteer. For example, imaging of retinal pathology is presented in three cases of advanced age-related macular degeneration.

  8. Reconsidering the advantages of the three-dimensional representation of the interferometric transform for imaging with non-coplanar baselines and wide fields of view (United States)

    Smith, D. M. P.; Young, A.; Davidson, D. B.


    Radio telescopes with baselines that span thousands of kilometres and with fields of view that span tens of degrees have been recently deployed, such as the Low Frequency Array, and are currently being developed, such as the Square Kilometre Array. Additionally, there are proposals for space-based instruments with all-sky imaging capabilities, such as the Orbiting Low Frequency Array. Such telescopes produce observations with three-dimensional visibility distributions and curved image domains. In most work to date, the visibility distribution has been converted to a planar form to compute the brightness map using a two-dimensional Fourier transform. The celestial sphere is faceted in order to counter pixel distortion at wide angles, with each such facet requiring a unique planar form of the visibility distribution. Under the above conditions, the computational and storage complexities of this approach can become excessive. On the other hand, when using the direct Fourier transform approach, which maintains the three-dimensional shapes of the visibility distribution and celestial sphere, the non-coplanar visibility component requires no special attention. Furthermore, as the celestial samples are placed directly on the curved surface of the celestial sphere, pixel distortion at wide angles is avoided. In this paper, a number of examples illustrate that under these conditions (very long baselines and very wide fields of view) the costs of the direct Fourier transform may be comparable to (or even lower than) methods that utilise the two-dimensional fast Fourier transform.

  9. 3D wide field-of-view Gabor-domain optical coherence microscopy advancing real-time in-vivo imaging and metrology (United States)

    Canavesi, Cristina; Cogliati, Andrea; Hayes, Adam; Tankam, Patrice; Santhanam, Anand; Rolland, Jannick P.


    Real-time volumetric high-definition wide-field-of-view in-vivo cellular imaging requires micron-scale resolution in 3D. Compactness of the handheld device and distortion-free images with cellular resolution are also critically required for onsite use in clinical applications. By integrating a custom liquid lens-based microscope and a dual-axis MEMS scanner in a compact handheld probe, Gabor-domain optical coherence microscopy (GD-OCM) breaks the lateral resolution limit of optical coherence tomography through depth, overcoming the tradeoff between numerical aperture and depth of focus, enabling advances in biotechnology. Furthermore, distortion-free imaging with no post-processing is achieved with a compact, lightweight handheld MEMS scanner that obtained a 12-fold reduction in volume and 17-fold reduction in weight over a previous dual-mirror galvanometer-based scanner. Approaching the holy grail of medical imaging - noninvasive real-time imaging with histologic resolution - GD-OCM demonstrates invariant resolution of 2 μm throughout a volume of 1 x 1 x 0.6 mm3, acquired and visualized in less than 2 minutes with parallel processing on graphics processing units. Results on the metrology of manufactured materials and imaging of human tissue with GD-OCM are presented.

  10. Development of Tiled Imaging CZT Detectors for Sensitive Wide-Field Hard X-Ray Surveys to EXIST (United States)

    Grindlay, J.; Hong, J.; Allen, B.; Barthelmy, S.; Baker, R.


    Motivated by the proposed EXIST mission, a "medium-class" space observatory to survey black holes and the Early Universe proposed to the 2010 NAS/NRC Astronomy and Astrophysics Decadal Survey, we have developed the first "large" area 256 sq cm close-tiled (0.6 mm gaps) hard X-ray (20-600 keV) imaging detector employing pixelated (2.5 mm) CdZnTe (CZT) detectors, each 2 x 2 x 0.5 cubic cm. We summarize the design, development and operation of this detector array (8 x 8 CZTs) and its performance as the imager for a coded aperture telescope on a high altitude (40 km) balloon flight in October. 2009, as the ProtoEX1STl payload. We then outline our current development of a second-generation imager, ProtcEXIST2. with 0.6 mm pixels on a 32 x 32 array on each CZT, and how it will lead to the ultimate imaging system needed for EXIST. Other applications of this technology will also be mentioned.

  11. Development of tiled imaging CZT detectors for sensitive wide-field hard X-ray surveys to EXIST (United States)

    Grindlay, J.; Hong, J.; Allen, B.; Barthelmy, S.; Baker, R.


    Motivated by the proposed EXIST mission, a "medium-class" space observatory to survey black holes and the Early Universe proposed to the 2010 NAS/NRC Astronomy and Astrophysics Decadal Survey, we have developed the first "large" area 256 cm 2 close-tiled (0.6 mm gaps) hard X-ray (20-600 keV) imaging detector employing pixelated (2.5 mm) CdZnTe (CZT) detectors, each 2×2×0.5 cm 3. We summarize the design, development and operation of this detector array (8×8 CZTs) and its performance as the imager for a coded aperture telescope on a high altitude (40 km) balloon flight in October, 2009, as the ProtoEXIST1 payload. We then outline our current development of a second-generation imager, ProtoEXIST2, with 0.6 mm pixels on a 32×32 array on each CZT, and how it will lead to the ultimate imaging system needed for EXIST. Other applications of this technology will also be mentioned.

  12. Evaluation of Visunex Medical's PanoCam(TM) LT and PanoCam(TM) Pro wide-field imaging systems for the screening of ROP in newborn infants. (United States)

    Wood, Edward H; Moshfeghi, Andrew A; Nudleman, Eric D; Moshfeghi, Darius M


    Retinopathy of Prematurity (ROP) is a leading cause of childhood blindness. The incidence of ROP is rising, placing greater demands on the healthcare providers that serve these patients and their families. Telemedicine remote digital fundus imaging (TM-RDFI) plays a pivotal role in ROP management, and has allowed for the expansion of ROP care into previously underserved areas. A broad literature review through the pubmed index was undertaken with the goal of summarizing the current state of ROP and guidelines for its screening . Furthermore, all currently used telemedicine remote digital fundus imaging devices were analyzed both via the literature and the companies' websites/brochures. Finally, the PanoCam LT™ and PanoCam™ Pro created by Visunex Medical were analyzed via the company website/brochures. Expert commentary: The PanoCam LT™ and PanoCam™ Pro have recently been approved for use within the USA and CE marked for international commercialization in European Union and other countries requiring CE mark. These wide-field imaging systems have the intended use of ophthalmic imaging of all newborn babies and meet the requirements for ROP screening, thereby serving as competition within the ROP screening market previously dominated by one camera imaging system.

  13. Photon counting imaging with an electron-bombarded CCD: Towards wide-field time-correlated single photon counting (TCSPC)

    Energy Technology Data Exchange (ETDEWEB)

    Hirvonen, Liisa M.; Jiggins, Stephen; Sergent, Nicolas; Zanda, Gianmarco; Suhling, Klaus, E-mail:


    Single photon detecting capabilities of an electron-bombarded CCD (EBCCD), where a photon is converted into a photoelectron that is accelerated through a high voltage before hitting the CCD chip, were characterised. The photon event pulse height distribution was found to be linearly dependent on the gain voltage. Based on these results, we propose that a gain voltage sweep during exposure in an EBCCD or EBCMOS camera would allow photon arrival time determination from the photon event pulse height with sub-frame exposure time resolution. This effectively uses an electron-bombarded sensor as a parallel-processing photoelectronic time-to-amplitude converter (TAC), or a 2-dimensional streak camera. Several applications that require timing of photon arrival, including fluorescence lifetime imaging microscopy (FLIM), may benefit from this approach. Moreover, the EBCCD was used on a fluorescence microscope to image fluorescently labelled cells in single photon counting mode.

  14. Preclinical evaluation of spatial frequency domain-enabled wide-field quantitative imaging for enhanced glioma resection (United States)

    Sibai, Mira; Fisher, Carl; Veilleux, Israel; Elliott, Jonathan T.; Leblond, Frederic; Roberts, David W.; Wilson, Brian C.


    5-Aminolevelunic acid-induced protoporphyrin IX (PpIX) fluorescence-guided resection (FGR) enables maximum safe resection of glioma by providing real-time tumor contrast. However, the subjective visual assessment and the variable intrinsic optical attenuation of tissue limit this technique to reliably delineating only high-grade tumors that display strong fluorescence. We have previously shown, using a fiber-optic probe, that quantitative assessment using noninvasive point spectroscopic measurements of the absolute PpIX concentration in tissue further improves the accuracy of FGR, extending it to surgically curable low-grade glioma. More recently, we have shown that implementing spatial frequency domain imaging with a fluorescent-light transport model enables recovery of two-dimensional images of [PpIX], alleviating the need for time-consuming point sampling of the brain surface. We present first results of this technique modified for in vivo imaging on an RG2 rat brain tumor model. Despite the moderate errors in retrieving the absorption and reduced scattering coefficients in the subdiffusive regime of 14% and 19%, respectively, the recovered [PpIX] maps agree within 10% of the point [PpIX] values measured by the fiber-optic probe, validating its potential as an extension or an alternative to point sampling during glioma resection.

  15. Low-frequency wide-field fluorescence lifetime imaging using a high-power near-infrared light-emitting diode light source. (United States)

    Gioux, Sylvain; Lomnes, Stephen J; Choi, Hak Soo; Frangioni, John V


    Fluorescence lifetime imaging (FLi) could potentially improve exogenous near-infrared (NIR) fluorescence imaging, because it offers the capability of discriminating a signal of interest from background, provides real-time monitoring of a chemical environment, and permits the use of several different fluorescent dyes having the same emission wavelength. We present a high-power, LED-based, NIR light source for the clinical translation of wide-field (larger than 5 cm in diameter) FLi at frequencies up to 35 MHz. Lifetime imaging of indocyanine green (ICG), IRDye 800-CW, and 3,3(')-diethylthiatricarbocyanine iodide (DTTCI) was performed over a large field of view (10 cm by 7.5 cm) using the LED light source. For comparison, a laser diode light source was employed as a gold standard. Experiments were performed both on the bench by diluting the fluorescent dyes in various chemical environments in Eppendorf tubes, and in vivo by injecting the fluorescent dyes mixed in Matrigel subcutaneously into CD-1 mice. Last, measured fluorescence lifetimes obtained using the LED and the laser diode sources were compared with those obtained using a state-of-the-art time-domain imaging system and with those previously described in the literature. On average, lifetime values obtained using the LED and the laser diode light sources were consistent, exhibiting a mean difference of 3% from the expected values and a coefficient of variation of 12%. Taken together, our study offers an alternative to laser diodes for clinical translation of FLi and explores the use of relatively low frequency modulation for in vivo imaging.

  16. Reflection, phase and en- face sectional imaging of scattering objects using quasi-single-shot wide-field optical coherence tomography (United States)

    Anna, Tulsi; Kimura, Satoshi; Mehta, Dalip Singh; Sato, Manabu


    We report a quasi-single-shot wide-field optical coherence tomography system that enables to measure the reflection, phase and en- face OCT images from the same setup using the glass jig. The jig consisting of a wedge glass substrate and a glue dot is contacted to the tissue surfaces, and the data within glue dot is used to reduce the phase noise of the interference signal. The reconstructed image size of the object was 4.0 mm × 4.3 mm. The standard deviation (STD) of the phase variation was minimized by 54 % and obtained to be 0.027 rad for the poke tissue. The corresponding STD in optical path length change was measured to be 1.4 nm. The refractive index of the water and poke tissue at the surface is also evaluated as 1.36 and 1.39, respectively, using reflection intensity images. Further, the en- face sectional images of the tissue sample are also measured.

  17. Noncontact and Wide-Field Characterization of the Absorption and Scattering Properties of Apple Fruit Using Spatial-Frequency Domain Imaging (United States)

    Hu, Dong; Fu, Xiaping; He, Xueming; Ying, Yibin


    Spatial-frequency domain imaging (SFDI), as a noncontact, low-cost and wide-field optical imaging technique, offers great potential for agro-product safety and quality assessment through optical absorption (μa) and scattering (μ) property measurements. In this study, a laboratory-based SFDI system was constructed and developed for optical property measurement of fruits and vegetables. The system utilized a digital light projector to generate structured, periodic light patterns and illuminate test samples. The diffuse reflected light was captured by a charge coupled device (CCD) camera with the resolution of 1280 × 960 pixels. Three wavelengths (460, 527, and 630 nm) were selected for image acquisition using bandpass filters in the system. The μa and μ were calculated in a region of interest (ROI, 200 × 300 pixels) via nonlinear least-square fitting. Performance of the system was demonstrated through optical property measurement of ‘Redstar’ apples. Results showed that the system was able to acquire spatial-frequency domain images for demodulation and calculation of the μa and μ. The calculated μa of apple tissue experiencing internal browning (IB) were much higher than healthy apple tissue, indicating that the SFDI technique had potential for IB tissue characterization.

  18. Michelson wide-field stellar interferometry : Principles and experimental verification

    NARCIS (Netherlands)

    Montilla, I.; Pereira, S.F.; Braat, J.J.M.


    A new interferometric technique for Michelson wide-field interferometry is presented that consists of a Michelson pupil-plane combination scheme in which a wide field of view can be achieved in one shot. This technique uses a stair-shaped mirror in the intermediate image plane of each telescope in

  19. The ESO-Spitzer Imaging extragalactic Survey (ESIS). II. VIMOS I, z wide field imaging of ELAIS-S1 and selection of distant massive galaxies (United States)

    Berta, S.; Rubele, S.; Franceschini, A.; Held, E. V.; Rizzi, L.; Rodighiero, G.; Cimatti, A.; Dias, J. E.; Feruglio, C.; La Franca, F.; Lonsdale, C. J.; Maiolino, R.; Matute, I.; Rowan-Robinson, M.; Sacchi, N.; Zamorani, G.


    Context: The ESO-Spitzer Imaging extragalactic Survey (ESIS) is the optical follow up of the Spitzer Wide-area Infra-Red Extragalactic survey (SWIRE) in the ELAIS-S1 region of the sky. Aims: In the era of observational cosmology, the main efforts are focused on the study of galaxy evolution and its environmental dependence. Wide area, multiwavelength, extragalactic surveys are needed in order to probe sufficiently large volumes, minimize cosmic variance and find significant numbers of rare objects. Methods: We present VIMOS I and z band imaging belonging to the ESIS survey. A total of ~4 deg2 was targeted in I and ~1 deg2 in z. Accurate data processing includes removal of fringing, and mosaicking of the complex observing pattern. Completeness levels and photometric uncertainties are estimated through simulations. The multi-wavelength data available in the area are exploited to identify high-redshift galaxies, using the IR-peak technique. Results: More than 300 000 galaxies have been detected in the I band and ~50 000 in the z band. Object coordinates are defined within an uncertainty of ~0.2 arcsec rms, with respect to GSC 2.2. We reach a 90% average completeness at 23.1 and 22.5 mag (Vega) in the I and z bands, respectively. On the basis of IRAC colors, we identify galaxies having the 1.6 μm stellar peak shifted to z = 1-3. The new I, z band data provide reliable constraints to help avoid low-redshift interlopers and reinforce this selection. Roughly 1000 galaxies between z = 2-3 are identified over the ESIS ~4 deg^2, at the SWIRE 5.8 μm depth (25.8 μJy at 3σ). These are the best galaxy candidates to dominate the massive tail (M > 1011 M_⊙) of the z > 2 mass function. Based on observations collected at the European Southern Observatory, Chile, ESO No. 168.A-0322(A). ESIS web page: Appendix A, Tables 4 and 5 are only available at The full I and z band catalogs (see Table [see full textsee full textsee full

  20. WFIRST: Simulating the Wide-Field Sky (United States)

    Peeples, Molly; WFIRST Wide Field Imager Simulations Working Group


    As astronomy’s first high-resolution wide-field multi-mode instrument, simulated data will play a vital role in the planning for and analysis of data from WFIRST’s WFI (Wide Field Imager) instrument. Part of the key to WFIRST’s scientific success lies in our ability to push the systematics limit, but in order to do so, the WFI pipeline will need to be able to measure and take out said systematics. The efficacy of this pipeline can only be verified with large suites of synthetic data; these data must include both the range of astrophysical sky scenes (from crowded starfields to high-latitude grism data observations) and the systematics from the detector and telescope optics the WFI pipeline aims to mitigate. We summarize here(1) the status of current and planned astrophysical simulations in support of the WFI,(2) the status of current WFI instrument simulators and requirements on future generations thereof, and(3) plans, methods, and requirements on interfacing astrophysical simulations and WFI instrument simulators.

  1. Michelson wide-field stellar interferometry

    NARCIS (Netherlands)

    Montilla, I.


    The main goal of this thesis is to develop a system to permit wide field operation of Michelson Interferometers. A wide field of view is very important in applications such as the observation of extended or multiple objects, the fringe acquisition and/ or tracking on a nearby unresolved object, and

  2. Flight performance of an advanced CZT imaging detector in a balloon-borne wide-field hard X-ray telescope—ProtoEXIST1 (United States)

    Hong, J.; Allen, B.; Grindlay, J.; Barthelemy, S.; Baker, R.; Garson, A.; Krawczynski, H.; Apple, J.; Cleveland, W. H.


    We successfully carried out the first high-altitude balloon flight of a wide-field hard X-ray coded-aperture telescope ProtoEXIST1, which was launched from the Columbia Scientific Balloon Facility at Ft. Sumner, New Mexico on October 9, 2009. ProtoEXIST1 is the first implementation of an advanced CdZnTe (CZT) imaging detector in our ongoing program to establish the technology required for next generation wide-field hard X-ray telescopes such as the High Energy Telescope (HET) in the Energetic X-ray Imaging Survey Telescope (EXIST). The CZT detector plane in ProtoEXIST1 consists of an 8×8 array of closely tiled 2 cm×2 cm×0.5 cm thick pixellated CZT crystals, each with 8×8 pixels, mounted on a set of readout electronics boards and covering a 256 cm2 active area with 2.5 mm pixels. A tungsten mask, mounted at 90 cm above the detector provides shadowgrams of X-ray sources in the 30-600 keV band for imaging, allowing a fully coded field of view of 9°×9° (and 19°×19° for 50% coding fraction) with an angular resolution of 20‧. In order to reduce the background radiation, the detector is surrounded by semi-graded (Pb/Sn/Cu) passive shields on the four sides all the way to the mask. On the back side, a 26 cm×26 cm×2 cm CsI(Na) active shield provides signals to tag charged particle induced events as well as ≳100keV background photons from below. The flight duration was only about 7.5 h due to strong winds (60 knots) at float altitude (38-39 km). Throughout the flight, the CZT detector performed excellently. The telescope observed Cyg X-1, a bright black hole binary system, for ˜1h at the end of the flight. Despite a few problems with the pointing and aspect systems that caused the telescope to track about 6.4° off the target, the analysis of the Cyg X-1 data revealed an X-ray source at 7.2σ in the 30-100 keV energy band at the expected location from the optical images taken by the onboard daytime star camera. The success of this first flight is very

  3. Microneedles rollers as a potential device to increase ALA diffusion and PpIX production: evaluations by wide-field fluorescence imaging and fluorescence spectroscopy (United States)

    Gracielli Sousa, R. Phamilla; de Menezes, Priscila F. C.; Fujita, Alessandra K. L.; Requena, Michelle B.; Govone, Angelo Biassi; Escobar, André; de Nardi, Andrigo B.; Kurachi, Cristina; Bagnato, Vanderlei Salvador


    One of the limitations of topical photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) is the poor ability to penetrate biological barriers of skin and the recurrence rates in treatments. This study aimed to identify possible signs of increased diffusion of ALA-induced PpIX by fluorescence images and fluorescence spectroscopy. The research was done using in vivo porcine skin model. Before the cream application, microholes was performed with microneedles rollers in only one direction, afterward the ALA cream was applied at a 2.5cm2 area in triplicate and an occlusive dressing was placed. PpIX production was monitored using fluorescence spectroscopy collected at skin surface after 70, 100, 140, and 180 minutes of ALA incubation. About 100 fluorescence spectra of each treatment were collected, distributed by about five points for each site. Wide-field fluorescence imaging was made after 70, 90, and 170 minutes after treatment. The results obtained by imaging analysis indicated increase of the PpIX diffusion in the skin surface using the microneedles rollers (MNs) before ALA application. Circular regions of red fluorescence around the microholes were observed. In addition, the fluorescence spectra showed a greater intensity (2 times as many) in groups microneedles rollers associated. In conclusion, our data shown greater homogeneity and PpIX production in the groups pre-treated with microneedles indicating that the technique can be used to greater uniformity of PpIX production throughout the area to be treated reducing the chances of recurrent tumor as well as has potential for decreasing the time of therapy. (FUNDING SUPPORT:CAPES, CNPq and FAPESP)

  4. A wide field of view plasma spectrometer (United States)

    Skoug, R. M.; Funsten, H. O.; Möbius, E.; Harper, R. W.; Kihara, K. H.; Bower, J. S.


    We present a fundamentally new type of space plasma spectrometer, the wide field of view plasma spectrometer, whose field of view is > 1.25π ster using fewer resources than traditional methods. The enabling component is analogous to a pinhole camera with an electrostatic energy-angle filter at the image plane. Particle energy-per-charge is selected with a tunable bias voltage applied to the filter plate relative to the pinhole aperture plate. For a given bias voltage, charged particles from different directions are focused by different angles to different locations. Particles with appropriate locations and angles can transit the filter plate and are measured using a microchannel plate detector with a position-sensitive anode. Full energy and angle coverage are obtained using a single high-voltage power supply, resulting in considerable resource savings and allowing measurements at fast timescales. We present laboratory prototype measurements and simulations demonstrating the instrument concept and discuss optimizations of the instrument design for application to space measurements.

  5. A Wide-Field Fluorescence Microscope Extension for Ultrafast Screening of One-Bead One-Compound Libraries Using a Spectral Image Subtraction Approach. (United States)

    Heusermann, Wolf; Ludin, Beat; Pham, Nhan T; Auer, Manfred; Weidemann, Thomas; Hintersteiner, Martin


    The increasing involvement of academic institutions and biotech companies in drug discovery calls for cost-effective methods to identify new bioactive molecules. Affinity-based on-bead screening of combinatorial one-bead one-compound libraries combines a split-mix synthesis design with a simple protein binding assay operating directly at the bead matrix. However, one bottleneck for academic scale on-bead screening is the unavailability of a cheap, automated, and robust screening platform that still provides a quantitative signal related to the amount of target protein binding to individual beads for hit bead ranking. Wide-field fluorescence microscopy has long been considered unsuitable due to significant broad spectrum autofluorescence of the library beads in conjunction with low detection sensitivity. Herein, we demonstrate how such a standard microscope equipped with LED-based excitation and a modern CMOS camera can be successfully used for selecting hit beads. We show that the autofluorescence issue can be overcome by an optical image subtraction approach that yields excellent signal-to-noise ratios for the detection of bead-associated target proteins. A polymer capillary attached to a semiautomated bead-picking device allows the operator to efficiently isolate individual hit beads in less than 20 s. The system can be used for ultrafast screening of >200,000 bead-bound compounds in 1.5 h, thereby making high-throughput screening accessible to a wider group within the scientific community.

  6. Optimizing ultrafast wide field-of-view illumination for high-throughput multi-photon imaging and screening of mutant fluorescent proteins (United States)

    Stoltzfus, Caleb; Mikhailov, Alexandr; Rebane, Aleksander


    Fluorescence induced by 1wo-photon absorption (2PA) and three-photon absorption (3PA) is becoming an increasingly important tool for deep-tissue microscopy, especially in conjunction with genetically-encoded functional probes such as fluorescent proteins (FPs). Unfortunately, the efficacy of the multi-photon excitation of FPs is notoriously low, and because relations between a biological fluorophore's nonlinear-optical properties and its molecular structure are inherently complex, there are no practical avenues available that would allow boosting the performance of current FPs. Here we describe a novel method, where we apply directed evolution to optimize the 2PA properties of EGFP. Key to the success of this approach consists in high-throughput screening of mutants that would allow selection of variants with promising 2PA and 3PA properties in a broad near-IR excitation range of wavelength. For this purpose, we construct and test a wide field-of-view (FOV), femtosecond imaging system that we then use to quantify the multi-photon excited fluorescence in the 550- 1600 nm range of tens of thousands of E. coli colonies expressing randomly mutated FPs in a standard 10 cm diameter Petri dish configuration. We present a quantitative analysis of different factors that are currently limiting the maximum throughput of the femtosecond multi-photon screening techniques and also report on quantitative measurement of absolute 2PA and 3PA cross sections spectra.

  7. Calibration and testing of wide-field UV instruments (United States)

    Frey, H. U.; Mende, S. B.; Loicq, J.; Habraken, S.


    As with all optical systems the calibration of wide-field ultraviolet (UV) systems includes three main areas: sensitivity, imaging quality, and imaging capability. The one thing that makes UV calibrations difficult is the need for working in vacuum substantially extending the required time and effort compared to visible systems. In theory a ray tracing and characterization of each individual component of the optical system (mirrors, windows, and grating) should provide the transmission efficiency of the combined system. However, potentially unknown effects (contamination, misalignment, and measurement errors) can make the final error too large and unacceptable for most applications. Therefore, it is desirable to test and measure the optical properties of the whole system in vacuum and compare the overall response to the response of a calibrated photon detector. A proper comparison then allows the quantification of individual sources of uncertainty and ensures that the whole instrument performance is within acceptable tolerances or pinpoints which parts fail to meet requirements. Based on the experience with the IMAGE Spectrographic Imager, the Wide-band Imaging Camera, and the ICON Far Ultraviolet instruments, we discuss the steps and procedures for the proper radiometric sensitivity and passband calibration, spot size, imaging distortions, flatfield, and field of view determination.Plain Language SummaryAs with all optical systems the calibration of wide-field ultraviolet (UV) systems includes three main areas: sensitivity, imaging quality, and imaging capability. The one thing that makes UV calibrations difficult is the need for working in vacuum substantially extending the required time and effort compared to visible systems. Based on the experience with the IMAGE Spectrographic Imager, the Wide-band Imaging Camera (WIC), and the ICON Far Ultraviolet instruments, we discuss the steps and procedures for the proper radiometric sensitivity and pass-band calibration

  8. Wide Area Wind Field Monitoring Status & Results

    Energy Technology Data Exchange (ETDEWEB)

    Alan Marchant; Jed Simmons


    Volume-scanning elastic has been investigated as a means to derive 3D dynamic wind fields for characterization and monitoring of wind energy sites. An eye-safe volume-scanning lidar system was adapted for volume imaging of aerosol concentrations out to a range of 300m. Reformatting of the lidar data as dynamic volume images was successfully demonstrated. A practical method for deriving 3D wind fields from dynamic volume imagery was identified and demonstrated. However, the natural phenomenology was found to provide insufficient aerosol features for reliable wind sensing. The results of this study may be applicable to wind field measurement using injected aerosol tracers.


    Energy Technology Data Exchange (ETDEWEB)

    Mechtley, M.; Windhorst, R. A.; Cohen, S. H.; Jansen, R. A.; Scannapieco, E. [School of Earth and Space Exploration, Arizona State University, P.O. Box 871404, Tempe, AZ 85287 (United States); Ryan, R. E.; Koekemoer, A. M. [Space Telescope Science Institute, Baltimore, MD 21218 (United States); Schneider, G.; Fan, X. [Steward Observatory, University of Arizona, Tucson, AZ 85721 (United States); Hathi, N. P. [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Keel, W. C. [Department of Physics and Astronomy, University of Alabama, Box 870324, Tuscaloosa, AL 35487 (United States); Roettgering, H. [Leiden Observatory, Leiden University, P.O. Box 9513, 2300 RA, Leiden (Netherlands); Schneider, D. P. [Department of Astronomy and Astrophysics, Pennsylvania State University, 525 Davey Laboratory, University Park, PA 16802 (United States); Strauss, M. A. [Princeton University Observatory, Princeton, NJ 08544 (United States); Yan, H. J. [Department of Physics and Astronomy, The University of Missouri, 701 South College Ave, Columbia, MO 65211 (United States)


    We report on deep near-infrared F125W (J) and F160W (H) Hubble Space Telescope Wide Field Camera 3 images of the z = 6.42 quasar J1148+5251 to attempt to detect rest-frame near-ultraviolet emission from the host galaxy. These observations included contemporaneous observations of a nearby star of similar near-infrared colors to measure temporal variations in the telescope and instrument point-spread function (PSF). We subtract the quasar point source using both this direct PSF and a model PSF. Using direct subtraction, we measure an upper limit for the quasar host galaxy of m{sub J} > 22.8 and m{sub H} > 23.0 AB mag (2 {sigma}). After subtracting our best model PSF, we measure a limiting surface brightness from 0.''3 to 0.''5 radius of {mu}{sub J} > 23.5 and {mu}{sub H} > 23.7 AB mag arcsec{sup -2} (2 {sigma}). We test the ability of the model subtraction method to recover the host galaxy flux by simulating host galaxies with varying integrated magnitude, effective radius, and Sersic index, and conducting the same analysis. These models indicate that the surface brightness limit ({mu}{sub J} > 23.5 AB mag arcsec{sup -2}) corresponds to an integrated upper limit of m{sub J} > 22-23 AB mag, consistent with the direct subtraction method. Combined with existing far-infrared observations, this gives an infrared excess log (IRX) > 1.0 and corresponding ultraviolet spectral slope {beta} > -1.2 {+-} 0.2. These values match those of most local luminous infrared galaxies, but are redder than those of almost all local star-forming galaxies and z {approx_equal} 6 Lyman break galaxies.

  10. Long-range and depth-selective imaging of macroscopic targets using low-coherence and wide-field interferometry (Conference Presentation) (United States)

    Woo, Sungsoo; Kang, Sungsam; Yoon, Changhyeong; Choi, Wonshik


    With the advancement of 3D display technology, 3D imaging of macroscopic objects has drawn much attention as they provide the contents to display. The most widely used imaging methods include a depth camera, which measures time of flight for the depth discrimination, and various structured illumination techniques. However, these existing methods have poor depth resolution, which makes imaging complicated structures a difficult task. In order to resolve this issue, we propose an imaging system based upon low-coherence interferometry and off-axis digital holographic imaging. By using light source with coherence length of 200 micro, we achieved the depth resolution of 100 micro. In order to map the macroscopic objects with this high axial resolution, we installed a pair of prisms in the reference beam path for the long-range scanning of the optical path length. Specifically, one prism was fixed in position, and the other prism was mounted on a translation stage and translated in parallel to the first prism. Due to the multiple internal reflections between the two prisms, the overall path length was elongated by a factor of 50. In this way, we could cover a depth range more than 1 meter. In addition, we employed multiple speckle illuminations and incoherent averaging of the acquired holographic images for reducing the specular reflections from the target surface. Using this newly developed system, we performed imaging targets with multiple different layers and demonstrated imaging targets hidden behind the scattering layers. The method was also applied to imaging targets located around the corner.

  11. The LOFT wide field monitor simulator

    DEFF Research Database (Denmark)

    Donnarumma, I.; Evangelista, Y.; Campana, R.


    We present the simulator we developed for the Wide Field Monitor (WFM) aboard the Large Observatory For Xray Timing (LOFT) mission, one of the four ESA M3 candidate missions considered for launch in the 2022–2024 timeframe. The WFM is designed to cover a large FoV in the same bandpass as the Larg...

  12. Electric Field Imaging Project (United States)

    Wilcutt, Terrence; Hughitt, Brian; Burke, Eric; Generazio, Edward


    NDE historically has focused technology development in propagating wave phenomena with little attention to the field of electrostatics and emanating electric fields. This work is intended to bring electrostatic imaging to the forefront of new inspection technologies, and new technologies in general. The specific goals are to specify the electric potential and electric field including the electric field spatial components emanating from, to, and throughout volumes containing objects or in free space.

  13. Observations and Modeling of Solar Coronal Structures Using High-Resolution Eclipse Images and Space-based Telescopes with Wide Field of View (United States)

    Lu, Muzhou; Pasachoff, J. M.; Su, Y.; Van Ballegooijen, A. A.; Seaton, D. B.; West, M.


    We present a comparison of the solar corona observed during the total solar eclipses on 2010 July 11 and on 2012 November 13. The white light images were taken at Easter Island in 2010 and at Northeast Queensland, Australia, in 2012; while the concurrent EUV images were take with SDO/AIA and PROBA2/SWAP. The 2010 eclipse was observed at the beginning of Sunspot Cycle 24 [1], which peaked near our 2012 observation. We compare a plethora of corona features in the white light images and reveal some interesting differences in the enhanced EUV images taken by SDO/AIA and PROBA2/SWAP. We construct potential field models using our newly refined Coronal Modeling System (CMS2) software with line-of-sight photospheric magnetograms from SDO/HMI. The source surface heights derived from detailed comparison between our models and observations are compared to the standard source-surface model. We also compare the dynamics of the two eclipse observations. Similar to the 2010 eclipse, a CME was observed using temporally spaced eclipse images. We address unresolved problems in the models and observations with the hope of correcting them for future eclipse observations, such as the 2017 total solar eclipse across the continental U.S. References [1] Pasachoff, J. M., Rusin, V., Druckmüllerová, H., Saniga, M., Lu, M., Malamut, C., Seaton, D. B., Golub, L., Engell, A. J., Hill, S. W., Lucas, R., 2011, ApJ, 734, 114

  14. Laser light-field fusion for wide-field lensfree on-chip phase contrast nanoscopy


    Kazemzadeh, Farnoud; Wong, Alexander


    Wide-field lensfree on-chip microscopy, which leverages holography principles to capture interferometric light-field encodings without lenses, is an emerging imaging modality with widespread interest given the large field-of-view compared to lens-based techniques. In this study, we introduce the idea of laser light-field fusion for lensfree on-chip phase contrast nanoscopy, where interferometric laser light-field encodings acquired using an on-chip setup with laser pulsations at different wav...

  15. Simulations of the x-ray imaging capabilities of the silicon drift detectors (SDD) for the LOFT wide-field monitor

    DEFF Research Database (Denmark)

    Evangelista, Y.; Campana, R.; Del Monte, E.


    The Large Observatory For X-ray Timing (LOFT), selected by ESA as one of the four Cosmic Vision M3 candidate missions to undergo an assessment phase, will revolutionize the study of compact objects in our galaxy and of the brightest supermassive black holes in active galactic nuclei. The Large Area...... Detector (LAD), carrying an unprecedented effective area of 10 m^2, is complemented by a coded-mask Wide Field Monitor, in charge of monitoring a large fraction of the sky potentially accessible to the LAD, to provide the history and context for the sources observed by LAD and to trigger its observations...

  16. Advanced MOKE magnetometry in wide-field Kerr-microscopy (United States)

    Soldatov, I. V.; Schäfer, R.


    The measurement of MOKE (Magneto-Optical Kerr Effect) magnetization loops in a wide-field Kerr microscope offers the advantage that the relevant domain images along the loop can be readily recorded. As the microscope's objective lens is exposed to the magnetic field, the loops are usually strongly distorted by non-linear Faraday rotations of the polarized light that occur in the objective lens and that are superimposed to the MOKE signal. In this paper, an experimental method, based on a motorized analyzer, is introduced which allows to compensate the Faraday contributions, thus leading to pure MOKE loops. A wide field Kerr microscope, equipped with this technology, works well as a laser-based MOKE magnetometer, additionally offering domain images and thus providing the basis for loop interpretation.

  17. Invited Article: First flight in space of a wide-field-of-view soft x-ray imager using lobster-eye optics: Instrument description and initial flight results. (United States)

    Collier, Michael R; Porter, F Scott; Sibeck, David G; Carter, Jenny A; Chiao, Meng P; Chornay, Dennis J; Cravens, Thomas E; Galeazzi, Massimiliano; Keller, John W; Koutroumpa, Dimitra; Kujawski, Joseph; Kuntz, Kip; Read, Andy M; Robertson, Ina P; Sembay, Steve; Snowden, Steven L; Thomas, Nicholas; Uprety, Youaraj; Walsh, Brian M


    We describe the development, launch into space, and initial results from a prototype wide field-of-view soft X-ray imager that employs lobster-eye optics and targets heliophysics, planetary, and astrophysics science. The sheath transport observer for the redistribution of mass is the first instrument using this type of optics launched into space and provides proof-of-concept for future flight instruments capable of imaging structures such as the terrestrial cusp, the entire dayside magnetosheath from outside the magnetosphere, comets, the Moon, and the solar wind interaction with planetary bodies like Venus and Mars [Kuntz et al., Astrophys. J. (in press)].

  18. Wide-angle fundus imaging through the Boston keratoprosthesis. (United States)

    Sayegh, Rony R; Dohlman, Claes H


    To explore the feasibility and compare the outcomes of three wide-angle fundus cameras for imaging the peripheral retina through the Type 1 Boston keratoprosthesis. The noncontact Optos and the contact RetCam and Panoret wide-angle imaging systems were used to image the retina of eyes implanted with a keratoprosthesis. The failure-to-image rate, ease of acquisition, and quality of the images were noted, and the field of view was compared. Limitations and complications were recorded. Optos was then performed on patients referred for ultrasound B-scan evaluation, and the imaging findings were correlated. Retinal images with all three cameras were obtained on four eyes. Optos could be performed on all four eyes, RetCam on three, and Panoret on two. The field of view was comparable between the three different cameras. The best quality images were obtained with Optos. The external illumination of the Panoret made it impossible to image the only darkly pigmented individual in the series. Both contact devices failed to image another patient who was too agitated. Two patients had some ocular irritation from the coupling agent that resolved with replacement of the contact lens. Optos images were obtained on an additional six eyes, and findings correlated well with those on B-scan. Optos was superior to B-scan in an eye with silicone oil filling. Wide-angle fundus imaging through the keratoprosthesis is possible, and all three cameras performed similarly. The good quality of pictures obtained with the noncontact Optos, as well as its ease of use, comfort, and safety make it a preferred choice. Optos complements B-scan in the examination of the peripheral retina through the keratoprosthesis, and it may even be superior in certain settings.

  19. The development of WIFIS: a wide integral field infrared spectrograph (United States)

    Sivanandam, Suresh; Chou, Richard C. Y.; Moon, Dae-Sik; Ma, Ke; Millar-Blanchaer, Maxwell; Eikenberry, Stephen S.; Chun, Moo-Young; Kim, Sang Chul; Raines, Steven N.; Eisner, Joshua


    We present the current results from the development of a wide integral field infrared spectrograph (WIFIS). WIFIS offers an unprecedented combination of etendue and spectral resolving power for seeing-limited, integral field observations in the 0.9 - 1.8 μm range and is most sensitive in the 0.9 - 1.35 μ,m range. Its optical design consists of front-end re-imaging optics, an all-reflective image slicer-type, integral field unit (IFU) called FISICA, and a long-slit grating spectrograph back-end that is coupled with a HAWAII 2RG focal plane array. The full wavelength range is achieved by selecting between two different gratings. By virtue of its re-imaging optics, the spectrograph is quite versatile and can be used at multiple telescopes. The size of its field-of-view is unrivalled by other similar spectrographs, offering a 4.511x 1211 integral field at a 10-meter class telescope (or 2011 x 5011 at a 2.3-meter telescope). The use of WIFIS will be crucial in astronomical problems which require wide-field, two-dimensional spectroscopy such as the study of merging galaxies at moderate redshift and nearby star/planet-forming regions and supernova remnants. We discuss the final optical design of WIFIS, and its predicted on-sky performance on two reference telescope platforms: the 2.3-m Steward Bok telescope and the 10.4-m Gran Telescopio Canarias. We also present the results from our laboratory characterization of FISICA. IFU properties such as magnification, field-mapping, and slit width along the entire slit length were measured by our tests. The construction and testing of WIFIS is expected to be completed by early 2013. We plan to commission the instrument at the 2.3-m Steward Bok telescope at Kitt Peak, USA in Spring 2013.

  20. New Subarray Readout Patterns for the ACS Wide Field Channel (United States)

    Golimowski, D.; Anderson, J.; Arslanian, S.; Chiaberge, M.; Grogin, N.; Lim, Pey Lian; Lupie, O.; McMaster, M.; Reinhart, M.; Schiffer, F.; Serrano, B.; Van Marshall, M.; Welty, A.


    At the start of Cycle 24, the original CCD-readout timing patterns used to generate ACS Wide Field Channel (WFC) subarray images were replaced with new patterns adapted from the four-quadrant readout pattern used to generate full-frame WFC images. The primary motivation for this replacement was a substantial reduction of observatory and staff resources needed to support WFC subarray bias calibration, which became a new and challenging obligation after the installation of the ACS CCD Electronics Box Replacement during Servicing Mission 4. The new readout patterns also improve the overall efficiency of observing with WFC subarrays and enable the processing of subarray images through stages of the ACS data calibration pipeline (calacs) that were previously restricted to full-frame WFC images. The new readout patterns replace the original 512×512, 1024×1024, and 2048×2046-pixel subarrays with subarrays having 2048 columns and 512, 1024, and 2048 rows, respectively. Whereas the original square subarrays were limited to certain WFC quadrants, the new rectangular subarrays are available in all four quadrants. The underlying bias structure of the new subarrays now conforms with those of the corresponding regions of the full-frame image, which allows raw frames in all image formats to be calibrated using one contemporaneous full-frame "superbias" reference image. The original subarrays remain available for scientific use, but calibration of these image formats is no longer supported by STScI.

  1. Construction of imaging system for wide-field-range ESR spectra using localized microwave field and its case study of crystal orientation in suspension of copper sulfate pentahydrate (CuSO4 . 5H2O). (United States)

    Tani, Atsushi; Ueno, Takehiro; Yamanaka, Chihiro; Katsura, Makoto; Ikeya, Motoji


    A scanning electron spin resonance (ESR) microscope using a localized microwave field was redesigned to measure ESR spectra from 0 to 400 mT using electromagnets. Divalent copper ion (Cu2+) in copper sulfate pentahydrate (CuSO4 . 5H2O) was imaged, after the powdered samples were cemented in silicone rubber under a magnetic field. The ratio of the two signal intensities at g=2.27 and 2.08 clearly indicates the orientation of the particles. This method can be used for mapping the local magnetic field and its direction.

  2. Construction of imaging system for wide-field-range ESR spectra using localized microwave field and its case study of crystal orientation in suspension of copper sulfate pentahydrate (CuSO{sub 4}.5H{sub 2}O)

    Energy Technology Data Exchange (ETDEWEB)

    Tani, Atsushi [Department of Earth and Space Science, Graduate School of Science, Osaka University, 1-1 Machikaneyama Toyonaka, Osaka 560-0043 (Japan)]. E-mail:; Ueno, Takehiro [Department of Earth and Space Science, Graduate School of Science, Osaka University, 1-1 Machikaneyama Toyonaka, Osaka 560-0043 (Japan); Yamanaka, Chihiro [Department of Earth and Space Science, Graduate School of Science, Osaka University, 1-1 Machikaneyama Toyonaka, Osaka 560-0043 (Japan); Katsura, Makoto [Department of Earth and Space Science, Graduate School of Science, Osaka University, 1-1 Machikaneyama Toyonaka, Osaka 560-0043 (Japan); Ikeya, Motoji [Department of Earth and Space Science, Graduate School of Science, Osaka University, 1-1 Machikaneyama Toyonaka, Osaka 560-0043 (Japan)


    A scanning electron spin resonance (ESR) microscope using a localized microwave field was redesigned to measure ESR spectra from 0 to 400mT using electromagnets. Divalent copper ion (Cu{sup 2+}) in copper sulfate pentahydrate (CuSO{sub 4}.5H{sub 2}O) was imaged, after the powdered samples were cemented in silicone rubber under a magnetic field. The ratio of the two signal intensities at g=2.27 and 2.08 clearly indicates the orientation of the particles. This method can be used for mapping the local magnetic field and its direction.

  3. Wide-Field Ultraviolet Spectrometer for Planetary Exospheres and Thermospheres (United States)

    Fillingim, M. O.; Wishnow, E. H.; Miller, T.; Edelstein, J.; Lillis, R. J.; Korpela, E.; England, S.; Shourt, W. V.; Siegmund, O.; McPhate, J.; Courtade, S.; Curtis, D. W.; Deighan, J.; Chaffin, M.; Harmoul, A.; Almatroushi, H. R.


    Understanding the composition, structure, and variability of a planet's upper atmosphere - the exosphere and thermosphere - is essential for understanding how the upper atmosphere is coupled to the lower atmosphere, magnetosphere and near-space environment, and the Sun. Ultraviolet spectroscopy can directly observe emissions from constituents in the exosphere and thermosphere. From such observations, the structure, composition, and variability can be determined.We will present the preliminary design for a wide field ultraviolet imaging spectrometer for remote sensing of planetary atmospheres. The imaging spectrometer achieves an extremely large instantaneous 110 degree field of view with no moving scanning mirror. The imaging resolution is very appropriate for extended atmospheric emission studies, with a resolution of better than 0.3 degrees at the center to 0.4 degrees at the edges of the field. The spectral range covers 120 - 170 nm, encompassing emissions from H, O, C, N, CO, and N2, with an average spectral resolution of 1.5 nm. The instrument is composed of a 2-element wide-field telescope, a 3-element Offner spectrometer, and a sealed MCP detector system contained within a compact volume of about 40 x 25 x 20 cm. We will present the optical and mechanical design as well as the predicted optical performance.The wide instantaneous FOV simplifies instrument and spacecraft operations by removing the need for multiple scans (either from a scan mirror or spacecraft slews) to cover the regions of interest. This instrumentation can allow for two-dimensional spectral information to be built up with simple spacecraft operation or just using spacecraft motion. Applications to the terrestrial geocorona and thermosphere will be addressed as well as applications to the upper atmospheres of other planetary objects.

  4. Structure from motion with wide circular field of view cameras. (United States)

    Micusík, Branislav; Pajdla, Tomás


    This paper presents a method for fully automatic and robust estimation of two-view geometry, autocalibration, and 3D metric reconstruction from point correspondences in images taken by cameras with wide circular field of view. We focus on cameras which have more than 180 degrees field of view and for which the standard perspective camera model is not sufficient, e.g., the cameras equipped with circular fish-eye lenses Nikon FC-E8 (183 degrees), Sigma 8mm-f4-EX (180 degrees), or with curved conical mirrors. We assume a circular field of view and axially symmetric image projection to autocalibrate the cameras. Many wide field of view cameras can still be modeled by the central projection followed by a nonlinear image mapping. Examples are the above-mentioned fish-eye lenses and properly assembled catadioptric cameras with conical mirrors. We show that epipolar geometry of these cameras can be estimated from a small number of correspondences by solving a polynomial eigenvalue problem. This allows the use of efficient RANSAC robust estimation to find the image projection model, the epipolar geometry, and the selection of true point correspondences from tentative correspondences contaminated by mismatches. Real catadioptric cameras are often slightly noncentral. We show that the proposed autocalibration with approximate central models is usually good enough to get correct point correspondences which can be used with accurate noncentral models in a bundle adjustment to obtain accurate 3D scene reconstruction. Noncentral camera models are dealt with and results are shown for catadioptric cameras with parabolic and spherical mirrors.

  5. Comparison of glomerular activity patterns by fMRI and wide-field calcium imaging: implications for principles underlying odor mapping (United States)

    Sanganahalli, Basavaraju G.; Rebello, Michelle R.; Herman, Peter; Papademetris, Xenophon; Shepherd, Gordon M.; Verhagen, Justus V.; Hyder, Fahmeed


    Functional imaging signals arise from distinct metabolic and hemodynamic events at the neuropil, but how these processes are influenced by pre- and post-synaptic activities need to be understood for quantitative interpretation of stimulus-evoked mapping data. The olfactory bulb (OB) glomeruli, spherical neuropil regions with well-defined neuronal circuitry, can provide insights into this issue. Optical calcium-sensitive fluorescent dye imaging (OICa2+) reflects dynamics of pre-synaptic input to glomeruli, whereas high-resolution functional magnetic resonance imaging (fMRI) using deoxyhemoglobin contrast reveals neuropil function within the glomerular layer where both pre- and post-synaptic activities contribute. We imaged odor-specific activity patterns of the dorsal OB in the same anesthetized rats with fMRI and OICa2+ and then co-registered the respective maps to compare patterns in the same space. Maps by each modality were very reproducible as trial-to-trial patterns for a given odor, overlapping by ~80%. Maps evoked by ethyl butyrate and methyl valerate for a given modality overlapped by ~80%, suggesting activation of similar dorsal glomerular networks by these odors. Comparison of maps generated by both methods for a given odor showed ~70% overlap, indicating similar odor-specific maps by each method. These results suggest that odor-specific glomerular patterns by high-resolution fMRI primarily tracks pre-synaptic input to the OB. Thus combining OICa2+ and fMRI lays the framework for studies of OB processing over a range of spatiotemporal scales, where OICa2+ can feature the fast dynamics of dorsal glomerular clusters and fMRI can map the entire glomerular sheet in the OB. PMID:26631819

  6. Wide-field subdiffraction RESOLFT microscopy using fluorescent protein photoswitching. (United States)

    Schwentker, Miriam A; Bock, Hannes; Hofmann, Michael; Jakobs, Stefan; Bewersdorf, Jörg; Eggeling, Christian; Hell, Stefan W


    Subdiffraction fluorescence imaging is presented in a parallelized wide-field arrangement exploiting the principle of reversible saturable/switchable optical transitions (RESOLFT). The diffraction barrier is overcome by photoswitching ensembles of the label protein asFP595 between a nonfluorescent off- and a fluorescent on-state. Relying on ultralow continuous-wave intensities, reversible protein switching facilitates parallelized fast image acquisition. The RESOLFT principle is implemented by illuminating with intensity distributions featuring zero intensity lines that are further apart than the conventional Abbe resolution limit. The subdiffraction resolution is verified by recording live Escherichia coli bacteria labeled with asFP595. The obtained resolution of 50 nm ( approximately lambda/12) is limited only by the spectroscopic properties of the proteins and the imperfections of the optical implementation, but not on principle grounds. (c) 2007 Wiley-Liss, Inc.

  7. DMD-based programmable wide field spectrograph for Earth observation (United States)

    Zamkotsian, Frédéric; Lanzoni, Patrick; Liotard, Arnaud; Viard, Thierry; Costes, Vincent; Hébert, Philippe-Jean


    In Earth Observation, Universe Observation and Planet Exploration, scientific return could be optimized in future missions using MOEMS devices. In Earth Observation, we propose an innovative reconfigurable instrument, a programmable wide-field spectrograph where both the FOV and the spectrum could be tailored thanks to a 2D micromirror array (MMA). For a linear 1D field of view (FOV), the principle is to use a MMA to select the wavelengths by acting on intensity. This component is placed in the focal plane of a first grating. On the MMA surface, the spatial dimension is along one side of the device and for each spatial point, its spectrum is displayed along the perpendicular direction: each spatial and spectral feature of the 1D FOV is then fully adjustable dynamically and/or programmable. A second stage with an identical grating recomposes the beam after wavelengths selection, leading to an output tailored 1D image. A mock-up has been designed, fabricated and tested. The micromirror array is the largest DMD in 2048 x 1080 mirrors format, with a pitch of 13.68μm. A synthetic linear FOV is generated and typical images have been recorded o at the output focal plane of the instrument. By tailoring the DMD, we could modify successfully each pixel of the input image: for example, it is possible to remove bright objects or, for each spatial pixel, modify the spectral signature. The very promising results obtained on the mock-up of the programmable wide-field spectrograph reveal the efficiency of this new instrument concept for Earth Observation.

  8. Visibility retrieval in Michelson wide-field stellar interferometry (United States)

    Montilla, I.; Sellos, J.; Pereira, S. F.; Braat, J. J. M.


    Wide-field interferometry has become a subject of increasing interest in recent years. New methods have been suggested in order to avoid the drawbacks of the standard wide-field method (homothetic mapping), which is not applicable when the aperture is highly diluted; for this reason, imaging with non-homothetic arrays is being extensively studied (E. Pedretti, et al., Astron. Astrophys. Suppl. Ser. 147 285 (2000); S. Gillet, et al., Astron. Astrophys. 400 393 (2003)). The field of view of a pupil-plane interferometer or a densified array consists of only a few resolution elements; in order to improve these systems, we have developed a new method consisting of a Michelson pupil-plane combination scheme where a wide field of view can be achieved in one shot. This technique, called the ‘staircase mirror’ approach, has been described in a previous paper (I. Montilla, S.F. Pereira and J.J.M. Braat, Appl. Optics 44 328 (2005)) and uses a stair-shaped mirror in the intermediate image plane of each telescope in the array, allowing for simultaneous correction of the differential delay for both the on- and off-axis image positions. Experimental results have been obtained showing the simultaneous recovery of the fringes of off-axis stars with an appreciable angular separation, and with a contrast similar to that of the on-axis reference star. With this example we demonstrate an increase of the field of view by a factor of 5, with no need for extra observation time. In this article, we present a further analysis of the method. We investigate how to retrieve the visibility when a star is focused on the edge of a step of the stair-shaped mirror. Even though the optical pathlength difference correction is discontinuous, we show both numerically and analytically that the visibility can be completely recovered, so that no information is lost. Our experimental results demonstrate that the visibility can be retrieved to within a 1% error.

  9. Pixel History for Advanced Camera for Surveys Wide Field Channel (United States)

    Borncamp, D.; Grogin, N.; Bourque, M.; Ogaz, S.


    Excess thermal energy present in a Charged Coupled Device (CCD) can result in additional electrical current. This excess charge is trapped within the silicon lattice structure of the CCD electronics. It can persist through multiple exposures and have an adverse effect on science performance of the detectors unless properly flagged and corrected for. The traditional way to correct for this extra charge is to take occasional long-exposure images with the camera shutter closed. These images, generally referred to as "dark" images, allow for the measurement of the thermal-electron contamination present in each pixel of the CCD lattice. This so-called "dark current" can then be subtracted from the science images by re-scaling the dark to the corresponding exposure times. Pixels that have signal above a certain threshold are traditionally marked as "hot" and flagged in the data quality array. Many users will discard these because of the extra current. However, these pixels may not be unusable because of an unreliable dark subtraction; if we find these pixels to be stable over an anneal period, we can properly subtract the charge and the extra Poisson noise from this dark current will be propagated into the error arrays. Here we present the results of a pixel history study that analyzes every individual pixel of the Hubble Space Telescope's (HST) Advanced Camera for Surveys (ACS) Wide Field Channel (WFC) CCDs over time and allows pixels that were previously flagged as unusable to be brought back into the science image as a reliable pixel.

  10. Thermal design of the Wide Field/Planetary Camera (United States)

    Garcia, R. D.; Jones, J. A.; Stultz, J. W.


    The Wide Field/Planetary Camera is an imaging system developed by the Jet Propulsion Laboratory for the NASA Hubble Space Telescope currently scheduled to be launched in December 1989 aboard the space shuttle. The temperature control design of the instrument utilizes multilayered insulation, electric resistance heaters, aluminum/ammonia heat pipes, thermoelectric coolers, temperature control coatings, and space radiators. A feedback control system maintains stable sensor temperatures. Thermal capacitance maintains stable optics and electronics temperatures during transient conditions. Schedule slips and launch delays have allowed extensive thermal testing of the instrument. Six instrument thermal vacuum tests and a spacecraft thermal vacuum test were performed. Several modifications have been made to the instrument to correct icing and contamination problems that have been discovered during thermal vacuum testing. This paper describes the thermal design, last instrument thermal vacuum test, results, and thermal model correlation.

  11. Low field magnetic resonance imaging (United States)

    Pines, Alexander; Sakellariou, Dimitrios; Meriles, Carlos A.; Trabesinger, Andreas H.


    A method and system of magnetic resonance imaging does not need a large homogenous field to truncate a gradient field. Spatial information is encoded into the spin magnetization by allowing the magnetization to evolve in a non-truncated gradient field and inducing a set of 180 degree rotations prior to signal acquisition.

  12. Selected aspects of wide-field stellar interferometry (United States)

    D'Arcio, Luigi Arsenio


    In Michelson stellar interferometry, the high-resolution information about the source structure is detected by performing observations with widely separated telescopes, interconnected to form an interferometer. At optical wavelengths, this method provides a technically viable approach for achieving angular resolutions in the milliarcsecond range, comparable to those of a 100 m diameter telescope, whose realization is beyond the immediate engineering capabilities. Considerable efforts are currently devoted to the definition of dedicated interferometric instruments, which will allow to address ambitious astronomical tasks such as high-resolution imaging, astrometry at microarcsecond level, and the direct detection of exoplanets. Astrometry and related techniques employ the so-called wide field-of-view interferometric mode, where phase measurements are performed simultaneously at two (or more) sources; often, the actual observable is the instantaneous phase difference of the two object signals. The future success of wide-field interferometry critically depends on the development of techniques for the accurate control of field-dependent (anisoplanatic) phase errors. In this thesis, we address two aspects of this problem in detail. The first one is theoretical in nature. For ground-based measurements, atmospheric turbulence is the largest source of random phase fluctuations between the on- and the off-axis fringes. We developed a model of the temporal power spectrum of this disturbance, whose validity is not limited to low frequencies only, as it is the case with earlier models. This extension opens the possibility of the analysis of dynamic issues, such as the determination of the allowable coherent integration time T for the off-axis fringes. The spectrum turns out to be well approximated by a sequences of four power-law branches. In first instance, its overall form is determined by the values of the baseline length, telescope diameter, and average beam separation in

  13. Wide-Field Slitless Spectroscopy with JWST/NIRISS (United States)

    Dixon, William V.


    The Near Infrared Imager and Slitless Spectrograph (NIRISS) is one of four scientific instruments that will fly aboard the James Webb Space Telescope (JWST) later in this decade. Among its capabilities, NIRISS offers wide-field slitless spectroscopy (WFSS) with a resolving power R = 150 over the wavelength range 1.0 to 2.25 microns using a pair of grisms that disperse light in orthogonal directions. Employing the software packages aXe and Source Extractor, we have developed the configuration files needed to model WFSS observations with NIRISS and to extract and calibrate the resulting spectra. These files, together with a cookbook detailing their use, are available on the JWST/NIRISS web site at STScI. Using these tools, we construct synthetic images of the near-IR sky, identify and extract the spectra of individual sources, and demonstrate that NIRISS can observe galaxies with redshifts up to z = 17. NIRISS is provided to the JWST project by the Canadian Space Agency under the leadership of René Doyon of the Université de Montréal. The prime contractor is COM DEV Canada.

  14. Transducer Field Imaging Using Acoustography

    Directory of Open Access Journals (Sweden)

    Jaswinder S. Sandhu


    Full Text Available A common current practice for transducer field mapping is to scan, point-by-point, a hydrophone element in a 2D raster at various distances from the transducer radiating surface. This approach is tedious, requiring hours of scanning time to generate full cross-sectional and/or axial field distributions. Moreover, the lateral resolution of the field distribution image is dependent on the indexing steps between data points. Acoustography is an imaging process in which an acousto-optical (AO area sensor is employed to record the intensity of an ultrasound wavefield on a two-dimensional plane. This paper reports on the application of acoustography as a simple but practical method for assessing transducer field characteristics. A case study performed on a commercial transducer is reported, where the radiated fields are imaged using acoustography and compared to the corresponding quantities that are predicted numerically.

  15. Wide-Field Infrared Survey Telescope (WFIRST) Integrated Modeling (United States)

    Liu, Kuo-Chia; Blaurock, Carl


    Contents: introduction to WFIRST (Wide-Field Infrared Survey Telescope) and integrated modeling; WFIRST stability requirement summary; instability mitigation strategies; dynamic jitter results; STOP (structural-thermal-optical performance) (thermal distortion) results; STOP and jitter capability limitations; model validation philosophy.

  16. Laser Light-field Fusion for Wide-field Lensfree On-chip Phase Contrast Microscopy of Nanoparticles. (United States)

    Kazemzadeh, Farnoud; Wong, Alexander


    Wide-field lensfree on-chip microscopy, which leverages holography principles to capture interferometric light-field encodings without lenses, is an emerging imaging modality with widespread interest given the large field-of-view compared to lens-based techniques. In this study, we introduce the idea of laser light-field fusion for lensfree on-chip phase contrast microscopy for detecting nanoparticles, where interferometric laser light-field encodings acquired using a lensfree, on-chip setup with laser pulsations at different wavelengths are fused to produce marker-free phase contrast images of particles at the nanometer scale. As a proof of concept, we demonstrate, for the first time, a wide-field lensfree on-chip instrument successfully detecting 300 nm particles across a large field-of-view of ~30 mm(2) without any specialized or intricate sample preparation, or the use of synthetic aperture- or shift-based techniques.

  17. Laser Light-field Fusion for Wide-field Lensfree On-chip Phase Contrast Microscopy of Nanoparticles (United States)

    Kazemzadeh, Farnoud; Wong, Alexander


    Wide-field lensfree on-chip microscopy, which leverages holography principles to capture interferometric light-field encodings without lenses, is an emerging imaging modality with widespread interest given the large field-of-view compared to lens-based techniques. In this study, we introduce the idea of laser light-field fusion for lensfree on-chip phase contrast microscopy for detecting nanoparticles, where interferometric laser light-field encodings acquired using a lensfree, on-chip setup with laser pulsations at different wavelengths are fused to produce marker-free phase contrast images of particles at the nanometer scale. As a proof of concept, we demonstrate, for the first time, a wide-field lensfree on-chip instrument successfully detecting 300 nm particles across a large field-of-view of ~30 mm2 without any specialized or intricate sample preparation, or the use of synthetic aperture- or shift-based techniques.

  18. Vestibular rehabilitation using a wide field of view virtual environment. (United States)

    Sparto, P J; Furman, J M; Whitney, S L; Hodges, L F; Redfern, M S


    This paper presents a theoretical justification for using a wide field of view (FOV) virtual reality display system for use in vestibular rehabilitation. A wide FOV environment offers some unique features that may be beneficial to vestibular rehabilitation. Primarily, optic flow information extracted from the periphery may be critical for recalibrating the sensory processes used by people with vestibular disorders. If this hypothesis is correct, then wide FOV systems will have an advantage over narrow field of view input devices such as head mounted or desktop displays. Devices that we have incorporated into our system that are critical for monitoring improvement in this clinical population will also be described.

  19. Hyperspectral light field image denoising (United States)

    Liu, Yun; Qi, Na; Cheng, Zhen; Liu, Dong; Xiong, Zhiwei


    Hyperspectral light field (HSLF) images with enriched spectral and angular information provide better representation of real scenes than conventional 2D images. In this paper, we propose a novel denoising method for HSLF images. The proposed method consists of two main steps. First, we generalize the intrinsic tensor sparsity (ITS) measure previously used for 3D hyperspectral image denoising to the 5D HSLF, by using the global correlation along the spectral dimension and the nonlocal similarity across the spatial and angular dimensions. Second, we further exploit the spatial-angular correlation by integrating light field super-resolution (SR) into the denoising process. In this way, the 5D HSLF can be better recovered. Experimental results validate the superior performance of the proposed method in terms of both objective and subjective quality on a self-collected HSLF dataset, in comparison with directly applying the state-of-the-art denoising methods.

  20. PERSPECTIVE: Toward a wide-field retinal prosthesis (United States)

    Ameri, Hossein; Ratanapakorn, Tanapat; Ufer, Stefan; Eckhardt, Helmut; Humayun, Mark S.; Weiland, James D.


    The purpose of this paper is to present a wide field electrode array that may increase the field of vision in patients implanted with a retinal prosthesis. Mobility is often impaired in patients with low vision, particularly in those with peripheral visual loss. Studies on low vision patients as well as simulation studies on normally sighted individuals have indicated a strong correlation between the visual field and mobility. In addition, it has been shown that an increased visual field is associated with a significant improvement in visual acuity and object discrimination. Current electrode arrays implanted in animals or human vary in size; however, the retinal area covered by the electrodes has a maximum projected visual field of about 10°. We have designed wide field electrode arrays that could potentially provide a visual field of 34°, which may significantly improve the mobility. Tests performed on a mechanical eye model showed that it was possible to fix 10 mm wide flexible polyimide dummy electrode arrays onto the retina using a single retinal tack. They also showed that the arrays could conform to the inner curvature of the eye. Surgeries on an enucleated porcine eye model demonstrated feasibility of implantation of 10 mm wide arrays through a 5 mm eye wall incision.

  1. Invited Article: First Flight in Space of a Wide-field-of-view Soft X-Ray Imager Using Lobster-Eye Optics: Instrument Description and Initial Flight Results (United States)

    Collier, Michael; Porter, F. Scott; Sibeck, David G.; Carter, Jenny A.; Chiao, Meng P.; Chomay, Dennis J.; Cravens, Thomas E.; Galeazzi, Massiniliano; Keller, John; Koutroumpa, Dimitra


    We describe the development, launch into space, and initial results from a prototype wide eld-of-view (FOV) soft X-ray imager that employs Lobster-eye optics and targets heliophysics, planetary, and astrophysics science. The Sheath Transport Observer for the Redistribution of Mass (STORM) is the rst instrument using this type of optics launched into space and provides proof-of-concept for future ight instruments capable of imaging structures such as the terrestrial cusp, the entire dayside magnetosheath from outside the magnetosphere, comets, the moon, and the solar wind interaction with planetary bodies like Venus and Mars.

  2. Combining image analysis, genome wide association studies and different field trials to reveal stable genetic regions related to panicle architecture and the number of spikelets per panicle in rice

    Directory of Open Access Journals (Sweden)

    Maria Camila Rebolledo


    Full Text Available Number of spikelets per panicle (NSP is a key trait to increase yield potential in rice (O. sativa. The architecture of the rice inflorescence which is mainly determined by the length and number of primary (PBL and PBN and secondary (SBL and SBN branches can influence NSP. Although several genes controlling panicle architecture and NSP in rice have been identified, there is little evidence of (i the genetic control of panicle architecture and NSP in different environments and (ii the presence of stable genetic associations with panicle architecture across environments. This study combines image phenotyping of 225 accessions belonging to a genetic diversity array of indica rice grown under irrigated field condition in two different environments and Genome Wide Association Studies (GWAS based on the genotyping of the diversity panel, providing 83,374 SNPs.Accessions sown under direct seeding in one environement had reduced Panicle Length (PL, NSP, PBN, PBL, SBN and SBL compared to those established under transplanting in the second environment. Across environments, NSP was significantly and positively correlated with PBN, SBN and PBL. However, the length of branches (PBL and SBL was not significantly correlated with variables related to number of branches (PBN and SBN , suggesting independent genetic control.Twenty- three GWAS sites were detected with P-values ≤ 1.0E-04 and 27 GWAS sites with p ≤ 5.9E-04. We found 17 GWAS sites related to NSP, 10 for PBN and 11 for SBN, 7 for PBL and 11 for SBL. This study revealed new regions related to NSP, but only three associations were related to both branching number (PBN and SBN and NSP. Two GWAS sites associated with SBL and SBN were stable across contrasting environments and were not related to genes previously reported.The new regions reported in this study can help improving NSP in rice for both direct seeded and transplanted conditions. The integrated approach of high-throughput phenotyping, multi

  3. Wide-field interferometric phase microscopy with molecular specificity using plasmonic nanoparticles. (United States)

    Turko, Nir A; Peled, Anna; Shaked, Natan T


    We present a method for adding molecular specificity to wide-field interferometric phase microscopy (IPM) by recording the phase signatures of gold nanoparticles (AuNPs) labeling targets of interest in biological cells. The AuNPs are excited by time-modulated light at a wavelength corresponding to their absorption spectral peak, evoking a photothermal (PT) effect due to their plasmonic resonance. This effect induces a local temperature rise, resulting in local refractive index and phase changes that can be detected optically. Using a wide-field interferometric phase microscope, we acquired an image sequence of the AuNP sample phase profile without requiring lateral scanning, and analyzed the time-dependent profile of the entire field of view using a Fourier analysis, creating a map of the locations of AuNPs in the sample. The system can image a wide-field PT phase signal from a cluster containing down to 16 isolated AuNPs. AuNPs are then conjugated to epidermal growth factor receptor (EGFR) antibodies and inserted to an EGFR-overexpressing cancer cell culture, which is imaged using IPM and verified by confocal microscopy. To the best of our knowledge, this is the first time wide-field interferometric PT imaging is performed at the subcellular level without the need for total internal reflection effects or scanning.

  4. Star Formation Rate Indicators in Wide-Field Infrared Survey ...

    Indian Academy of Sciences (India)


    field Infrared Survey Explorer (WISE) traces the SFR, we analyse 3.4, 4.6, 12 and 22 m data in a sample of ∼ 140,000 star-forming galaxies or star-forming regions covering a wide range in metallicity 7.66 < 12 + \\log (O/H) ...

  5. Wide-field Fourier ptychographic microscopy using laser illumination source (United States)

    Chung, Jaebum; Lu, Hangwen; Ou, Xiaoze; Zhou, Haojiang; Yang, Changhuei


    Fourier ptychographic (FP) microscopy is a coherent imaging method that can synthesize an image with a higher bandwidth using multiple low-bandwidth images captured at different spatial frequency regions. The method’s demand for multiple images drives the need for a brighter illumination scheme and a high-frame-rate camera for a faster acquisition. We report the use of a guided laser beam as an illumination source for an FP microscope. It uses a mirror array and a 2-dimensional scanning Galvo mirror system to provide a sample with plane-wave illuminations at diverse incidence angles. The use of a laser presents speckles in the image capturing process due to reflections between glass surfaces in the system. They appear as slowly varying background fluctuations in the final reconstructed image. We are able to mitigate these artifacts by including a phase image obtained by differential phase contrast (DPC) deconvolution in the FP algorithm. We use a 1-Watt laser configured to provide a collimated beam with 150 mW of power and beam diameter of 1 cm to allow for the total capturing time of 0.96 seconds for 96 raw FPM input images in our system, with the camera sensor’s frame rate being the bottleneck for speed. We demonstrate a factor of 4 resolution improvement using a 0.1 NA objective lens over the full camera field-of-view of 2.7 mm by 1.5 mm. PMID:27896016

  6. Wide-Field Optic for Autonomous Acquisition of Laser Link (United States)

    Page, Norman A.; Charles, Jeffrey R.; Biswas, Abhijit


    An innovation reported in Two-Camera Acquisition and Tracking of a Flying Target, NASA Tech Briefs, Vol. 32, No. 8 (August 2008), p. 20, used a commercial fish-eye lens and an electronic imaging camera for initially locating objects with subsequent handover to an actuated narrow-field camera. But this operated against a dark-sky background. An improved solution involves an optical design based on custom optical components for the wide-field optical system that directly addresses the key limitations in acquiring a laser signal from a moving source such as an aircraft or a spacecraft. The first challenge was to increase the light collection entrance aperture diameter, which was approximately 1 mm in the first prototype. The new design presented here increases this entrance aperture diameter to 4.2 mm, which is equivalent to a more than 16 times larger collection area. One of the trades made in realizing this improvement was to restrict the field-of-view to +80 deg. elevation and 360 azimuth. This trade stems from practical considerations where laser beam propagation over the excessively high air mass, which is in the line of sight (LOS) at low elevation angles, results in vulnerability to severe atmospheric turbulence and attenuation. An additional benefit of the new design is that the large entrance aperture is maintained even at large off-axis angles when the optic is pointed at zenith. The second critical limitation for implementing spectral filtering in the design was tackled by collimating the light prior to focusing it onto the focal plane. This allows the placement of the narrow spectral filter in the collimated portion of the beam. For the narrow band spectral filter to function properly, it is necessary to adequately control the range of incident angles at which received light intercepts the filter. When this angle is restricted via collimation, narrower spectral filtering can be implemented. The collimated beam (and the filter) must be relatively large to

  7. Wide field-of-view target detection and simultaneous narrow field of view target analysis (United States)

    Nichols, Richard W.; Miller, Geoffrey M.


    Protecting national borders, military and industrial complexes, national Infrastructure and high-value targets is critical to national security. Traditional solutions use a combination of ground surveillance radar, motion detection systems and video surveillance systems. Our development objective was to provide wide area 360-degree surveillance and ground-moving target detection using a passive optical system. In order to meet this objective, the development of an optical system capable of wide-area surveillance with intelligent cueing, high-resolution tracking and target identification is required. The predominant approach to optical surveillance has traditionally been gimbaled narrow field-of-view systems. These systems miss the majority of events occurring around them because of their inability to focus on anything other than a single event or object at any one time. Details of the system requirements definition, design trade studies and selected design configurations are discussed. The experimental results obtained during the current development phase have provided consistently high quality images and enhanced situational awareness. A summary of field validation methods and results is provided.

  8. Wide-field surface-enhanced CARS microscopy of cells (Conference Presentation) (United States)

    Fast, Alexander; Kenison, John T.; Potma, Eric O.


    We have previously demonstrated a total internal reflection, wide-field CARS microscope, where the signal is enhanced with the aid of a thin gold layer that supports surface plasmon polariton resonances. This surface-enhanced CARS microscope is capable of generating images of lipid structures in close proximity (visualizing lipids in aqueous media, including imaging of cells, with a unique surface-sensitive contrast that cannot be obtained with conventional CARS microscopy.

  9. Systems, computer-implemented methods, and tangible computer-readable storage media for wide-field interferometry (United States)

    Lyon, Richard G. (Inventor); Leisawitz, David T. (Inventor); Rinehart, Stephen A. (Inventor); Memarsadeghi, Nargess (Inventor)


    Disclosed herein are systems, computer-implemented methods, and tangible computer-readable storage media for wide field imaging interferometry. The method includes for each point in a two dimensional detector array over a field of view of an image: gathering a first interferogram from a first detector and a second interferogram from a second detector, modulating a path-length for a signal from an image associated with the first interferogram in the first detector, overlaying first data from the modulated first detector and second data from the second detector, and tracking the modulating at every point in a two dimensional detector array comprising the first detector and the second detector over a field of view for the image. The method then generates a wide-field data cube based on the overlaid first data and second data for each point. The method can generate an image from the wide-field data cube.

  10. DCC Case Study: Wide Field Astronomy Unit (WFAU)


    Donnelly, Martin


    Case study on the Wide Field Astronomy Unit (WFAU), Edinburgh. Outlines data curation issues with which WFAU is involved, with an emphasis on interoperability. Particular regard is given to the transfer and reuse of data collected from disparate sources. The case study also covers other factors influencing data curation, including methodological development, standards and legal issues, evaluation, and human factors. A technical appendix outlines the technologies used i...

  11. High-Speed and Wide-Field Photometry with TORTORA

    Directory of Open Access Journals (Sweden)

    G. Greco


    Full Text Available We present the photometric analysis of the extended sky fields observed by the TORTORA optical monitoring system. The technology involved in the TORTORA camera is based on the use of a fast TV-CCD matrix with an image intensifier. This approach can both significantly reduce the readout noise and shorten the focal length following to monitor relatively large sky regions with high temporal resolution and adequate detection limit. The performance of the system has been tested using the relative magnitudes of standard stars by means of long image sequences collected at different airmasses and at various intensities of the moon illumination. As expected from the previous laboratory measurements, artifact sources are negligible and do not affect the photometric results. The following analysis is based on a large sample of images acquired by the TORTORA instrument since July 2006.

  12. Extreme multiplex spectroscopy at wide-field 4-m telescopes (United States)

    Content, Robert; Shanks, Tom


    We describe the design and science case for a spectrograph for the prime focus of classical 4-m wide-field telescopes that can deliver at least 4000 MOS slits over a 1° field. This extreme multiplex capability means that 25000 galaxy redshifts can be measured in a single night, opening up the possibilities for large galaxy redshift surveys out to z~0.7 and beyond for the purpose of measuring the Baryon Acoustic Oscillation (BAO) scale and for many other science goals. The design features four cloned spectrographs and exploits the exclusive possibility of tiling the focal plane of wide-field 4-m telescopes with CCDs for multi-object spectroscopic purposes. In ~200 night projects, such spectrographs have the potential to make galaxy redshift surveys of ~6×106 galaxies over a wide redshift range and thus may provide a low-cost alternative to other survey routes such as WFMOS and SKA. Two of these extreme multiplex spectrographs are currently being designed for the AAT (NG1dF) and Calar Alto (XMS) 4-m class telescopes. NG2dF, a larger version for the AAT 2° field, would have 12 clones and at least 12000 slits. The clones use a transparent design including a grism in which all optics are smaller than the clone square subfield so that the clones can be tightly packed with little gaps between the contiguous fields. Only low cost glasses are used; the variations in chromatic aberrations between bands are compensated by changing one or two of the lenses adjacent to the grism. The total weight and length is smaller with a few clones than a unique spectrograph which makes it feasible to place the spectrograph at the prime focus.

  13. Image and video search engine for the World Wide Web (United States)

    Smith, John R.; Chang, Shih-Fu


    We describe a visual information system prototype for searching for images and videos on the World-Wide Web. New visual information in the form of images, graphics, animations and videos is being published on the Web at an incredible rate. However, cataloging this visual data is beyond the capabilities of current text-based Web search engines. In this paper, we describe a complete system by which visual information on the Web is (1) collected by automated agents, (2) processed in both text and visual feature domains, (3) catalogued and (4) indexed for fast search and retrieval. We introduce an image and video search engine which utilizes both text-based navigation and content-based technology for searching visually through the catalogued images and videos. Finally, we provide an initial evaluation based upon the cataloging of over one half million images and videos collected from the Web.

  14. Two wide-angle imaging neutral-atom spectrometers

    Energy Technology Data Exchange (ETDEWEB)

    McComas, D.J.


    The Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) mission provides a new capability for stereoscopically imaging the magnetosphere. By imaging the charge exchange neutral atoms over a broad energy range (1 < E , {approximately} 100 keV) using two identical instruments on two widely-spaced high-altitude, high-inclination spacecraft, TWINS will enable the 3-dimensional visualization and the resolution of large scale structures and dynamics within the magnetosphere for the first time. These observations will provide a leap ahead in the understanding of the global aspects of the terrestrial magnetosphere and directly address a number of critical issues in the ``Sun-Earth Connections`` science theme of the NASA Office of Space Science.

  15. World Wide Web Based Image Search Engine Using Text and Image Content Features (United States)

    Luo, Bo; Wang, Xiaogang; Tang, Xiaoou


    Using both text and image content features, a hybrid image retrieval system for Word Wide Web is developed in this paper. We first use a text-based image meta-search engine to retrieve images from the Web based on the text information on the image host pages to provide an initial image set. Because of the high-speed and low cost nature of the text-based approach, we can easily retrieve a broad coverage of images with a high recall rate and a relatively low precision. An image content based ordering is then performed on the initial image set. All the images are clustered into different folders based on the image content features. In addition, the images can be re-ranked by the content features according to the user feedback. Such a design makes it truly practical to use both text and image content for image retrieval over the Internet. Experimental results confirm the efficiency of the system.

  16. Radiometric calibration of wide-field camera system with an application in astronomy (United States)

    Vítek, Stanislav; Nasyrova, Maria; Stehlíková, Veronika


    Camera response function (CRF) is widely used for the description of the relationship between scene radiance and image brightness. Most common application of CRF is High Dynamic Range (HDR) reconstruction of the radiance maps of imaged scenes from a set of frames with different exposures. The main goal of this work is to provide an overview of CRF estimation algorithms and compare their outputs with results obtained under laboratory conditions. These algorithms, typically designed for multimedia content, are unfortunately quite useless with astronomical image data, mostly due to their nature (blur, noise, and long exposures). Therefore, we propose an optimization of selected methods to use in an astronomical imaging application. Results are experimentally verified on the wide-field camera system using Digital Single Lens Reflex (DSLR) camera.

  17. Wide field focal plane arrays for UKIRT and VISTA (United States)

    Ives, D.; Laidlaw, K.; Bezawada, N. N.

    This paper briefly describes the focal plane arrays of the UKIRT Wide Field Camera and the IR camera for the Visible and Infrared Survey Telescope for Astronomy (VISTA). Laboratory test results on the HAWAII-2 engineering grade detector are summarised. The interference problems resulting from the on-axis wavefront/autoguider sensors and their controllers (autoguider, wavefront sensor, etc.) are anticipated and possible options to eliminate or attenuate these effects are presented. Laboratory tests on the Electromagnetic Interference (EMI) issues are also reported.

  18. Blind deconvolution with principal components analysis for wide-field and small-aperture telescopes (United States)

    Jia, Peng; Sun, Rongyu; Wang, Weinan; Cai, Dongmei; Liu, Huigen


    Telescopes with a wide field of view (greater than 1°) and small apertures (less than 2 m) are workhorses for observations such as sky surveys and fast-moving object detection, and play an important role in time-domain astronomy. However, images captured by these telescopes are contaminated by optical system aberrations, atmospheric turbulence, tracking errors and wind shear. To increase the quality of images and maximize their scientific output, we propose a new blind deconvolution algorithm based on statistical properties of the point spread functions (PSFs) of these telescopes. In this new algorithm, we first construct the PSF feature space through principal component analysis, and then classify PSFs from a different position and time using a self-organizing map. According to the classification results, we divide images of the same PSF types and select these PSFs to construct a prior PSF. The prior PSF is then used to restore these images. To investigate the improvement that this algorithm provides for data reduction, we process images of space debris captured by our small-aperture wide-field telescopes. Comparing the reduced results of the original images and the images processed with the standard Richardson-Lucy method, our method shows a promising improvement in astrometry accuracy.

  19. Spatially Resolved Two-Dimensional Infrared Spectroscopy via Wide-Field Microscopy. (United States)

    Ostrander, Joshua S; Serrano, Arnaldo L; Ghosh, Ayanjeet; Zanni, Martin T


    We report the first wide-field microscope for measuring two-dimensional infrared (2D IR) spectroscopic images. We concurrently collect more than 16 000 2D IR spectra, made possible by a new focal plane array detector and mid-IR pulse shaping, to generate hyperspectral images with multiple frequency dimensions and diffraction-limited spatial resolution. Both frequency axes of the spectra are collected in the time domain by scanning two pairs of femtosecond pulses using a dual acousto-optic modulator pulse shaper. The technique is demonstrated by imaging a mixture of metal carbonyl absorbed polystyrene beads. The differences in image formation between FTIR and 2D IR microscopy are also explored by imaging a patterned USAF test target. We find that our 2D IR microscope has diffraction-limited spatial resolution and enhanced contrast compared to FTIR microscopy because of the nonlinear scaling of the 2D IR signal to the absorptivity coefficient for the vibrational modes. Images generated using off-diagonal peaks, created from vibrational anharmonicities, improve the molecular discrimination and eliminate noise. Two-dimensional wide-field IR microscopy provides information on vibrational lifetimes, molecular couplings, transition dipole orientations, and many other quantities that can be used for creating image contrast to help disentangle and interpret complex and heterogeneous samples. Such experiments made possible could include the study of amyloid proteins in tissues, protein folding in heterogeneous environments, and structural dynamics in devices employing mid-IR materials.

  20. A wide bandwidth electrostatic field sensor for lightning research (United States)

    Zaepfel, K. P.


    Data obtained from UHF Radar observation of direct-lightning strikes to the NASA F-106B airplane have indicated that most of the 690 strikes acquired during direct-strike lightning tests were triggered by the aircraft. As an aid in understanding the triggered lightning process, a wide bandwidth electric field measuring system was designed for the F-106B by implementing a clamped-detection signal processing concept originated at the Air Force Cambridge Research Lab in 1953. The detection scheme combines the signals from complementary stator pairs clamped to zero volts at the exact moment when each stator pair is maximally shielded by the rotor, a process that restores the dc level lost by the charge amplifier. The new system was implemented with four shutter-type field mills located at strategic points on the airplane. The bandwidth of the new system was determined in the laboratory to be from dc to over 100 Hz, whereas past designs had upper limits of 10 Hz to 100 Hz. To obtain the undisturbed electric field vector and total aircraft charge, the airborne field mill system is calibrated by using techniques involving results from ground and flight calibrations of the F-106B, laboratory tests of a metallized model, and a finite-difference time-domain electromagnetic computer code.

  1. Study of Wide Swath Synthetic Aperture Ladar Imaging Techology

    Directory of Open Access Journals (Sweden)

    Zhang Keshu


    Full Text Available Combining synthetic-aperture imaging and coherent-light detection technology, the weak signal identification capacity of Synthetic Aperture Ladar (SAL reaches the photo level, and the image resolution exceeds the diffraction limit of the telescope to obtain high-resolution images irrespective to ranges. This paper introduces SAL, including the development path, technology characteristics, and the restriction of imaging swath. On the basis of this, we propose to integrate the SAL technology for extending its swath. By analyzing the scanning-operation mode and the signal model, the paper explicitly proposes that the former mode will be the developmental trend of the SAL technology. This paper also introduces the flight demonstrations of the SAL and the imaging results of remote targets, showing the potential of the SAL in long-range, high-resolution, and scanning-imaging applications. The technology and the theory of the scanning mode of SAL compensates for the defects related to the swath and operation efficiency of the current SAL. It provides scientific foundation for the SAL system applied in wide swath, high resolution earth observation, and the ISAL system applied in space-targets imaging.

  2. A World Wide Web Region-Based Image Search Engine

    DEFF Research Database (Denmark)

    Kompatsiaris, Ioannis; Triantafyllou, Evangelia; Strintzis, Michael G.


    information. These features along with additional information such as the URL location and the date of index procedure are stored in a database. The user can access and search this indexed content through the Web with an advanced and user friendly interface. The output of the system is a set of links......In this paper the development of an intelligent image content-based search engine for the World Wide Web is presented. This system will offer a new form of media representation and access of content available in WWW. Information Web Crawlers continuously traverse the Internet and collect images...

  3. Firearm Projectile in the Maxillary Tuberosity Located by Adjunctive Examination of Wide-Field Optical Fluorescence. (United States)

    Andrade, Sérgio Araújo; Varotti, Fernando de Pilla; Bagnato, Vanderlei Salvador; Pratavieira, Sebastião


    Demonstrate the use of wide-field optical fluorescence as an adjunctive examination in a clinical routine to oral diagnosis. Use of wide-field optical fluorescence in the oral cavity has been restricted to topics related to the detection and diagnosis of oral cancer. In a regular medical appointment, a 58-year-old female patient, without any complaint or oral symptom, underwent the complementary examination by wide-field optical fluorescence. A device with high-power light-emitting diode emitting light centered at a wavelength of (400 ± 10) nm and maximum irradiance of (0.040 ± 0.008) W/cm(2) was used for fluorescence visualization. We report the location of a firearm projectile, intraosseous, in the maxillary tuberosity using wide-field optical fluorescence. It is evidenced that wide-field optical fluorescence, within a clinical routine, can provide relevant images and data, with an immediate result, without the use of ionizing radiation, enabling an efficient oral diagnosis.

  4. Simple concept for a wide-field lensless digital holographic microscope using a laser diode

    Directory of Open Access Journals (Sweden)

    Adinda-Ougba A.


    Full Text Available Wide-field, lensless digital holographic microscopy is a new microscopic imaging technique for telemedicine and for resource limited setting [1]. In this contribution we propose a very simple wide-field lensless digital holographic microscope using a laser diode. It is based on in-line digital holography which is capable to provide amplitude and phase images of a sample resulting from numerical reconstruction. The numerical reconstruction consists of the angular spectrum propagation method together with a phase retrieval algorithm. Amplitude and phase images of the sample with a resolution of ∽2 µm and with ∽24 mm2 field of view are obtained. We evaluate our setup by imaging first the 1951 USAF resolution test chart to verify the resolution. Second, we record holograms of blood smear and diatoms. The individual specimen can be easily identified after the numerical reconstruction. Our system is a very simple, compact and low-cost possibility of realizing a microscope capable of imaging biological samples. The availability of the phase provide topographic information of the sample extending the application of this system to be not only for biological sample but also for transparent microstructure. It is suitable for fault detection, shape and roughness measurements of these structures.

  5. Wide Binary Stars in the Galactic Field - A Statistical Approach (United States)

    Longhitano, Marco


    This thesis focuses on the statistical properties of wide binary (WB) star systems in the Galactic field. For the present study we select a homogeneous sample covering about 675 square degrees in the direction of the NGP. It contains nearly 670,000 MS stars with apparent magnitudes between 15 and 20.5 mag and spectral classes later than G5. The data were taken from the SDSS. We construct the two-point correlation function (2PCF) for angular separations between 2 and 30 arcsecs. The resulting clustering signal is modeled by means of the Wasserman-Weinberg technique. We show that the distribution of semi-major axis is consistent with the canonical Oepik law and infer that about 10% of all stars in the solar neighbourhood belong to a WB system. To reduce the noise from optical pairs and to increase the sensitivity of the analysis at larger separations, we include distance information from photometric parallaxes. Introducing a novel weighting procedure based on the binding probability of a double star, we infer the distribution of colours and mass ratios, which were carefully corrected for observational selection effects. About 4,000 WBs were taken into account statistically, whose components have masses between 0.2 and 0.85 solar masses. We find that the WB colour distribution is in accord with the colour distribution of single field stars. However, pairs with a mass difference exceeding 0.5 solar masses seem to be systematically underrepresented as compared to a random pairing of field stars. Our results are broadly in agreement with prior studies but a direct comparison is difficult and often impossible. The novel procedure presented in this thesis can be regarded as complementary to common proper motion studies, and constitutes a viable approach to study the statistical properties of WBs in the Galactic field.

  6. The design of the wide field monitor for LOFT

    DEFF Research Database (Denmark)

    Brandt, Søren; Hernanz, M.; Alvarez, L.


    is designed to carry on-board two instruments with sensitivity in the 2-50 keV range: a 10 m 2 class Large Area Detector (LAD) with a ... will be to detect transient sources to be observed by the LAD. However, thanks to its unique combination of a wide field of view (FoV) and energy resolution (better than 500 eV), the WFM will be also an excellent monitoring instrument to study the long term variability of many classes of X-ray sources. The WFM...... consists of 10 independent and identical coded mask cameras arranged in 5 pairs to provide the desired sky coverage. We provide here an overview of the instrument design, configuration, and capabilities of the LOFT WFM. The compact and modular design of the WFM could easily make the instrument concept...

  7. The UKIRT wide-field camera (WFCAM): commissioning and performance on the telescope (United States)

    Hirst, Paul; Casali, Mark; Adamson, Andy; Ives, Derek; Kerr, Tom


    The UKIRT Wide-Field Camera (WFCAM) was commissioned in two phases between October and December 2004, and March and April 2005. It has been carrying out full-scale sky survey operations since May 2005. This paper describes the commissioning process and compares actual performance on the telescope with specifications in four key areas: optical image quality including delivered FWHM and ghosting etc., noise and sensitivity in the infrared and on the visible autoguider, array artifacts such as crosstalk and persistent images, and observing efficiency. A comprehensive program of science verification was carried out before commencing the UKIRT Infrared Deep Sky Survey (UKIDSS).

  8. Prime focus wide-field corrector designs with lossless atmospheric dispersion correction

    Energy Technology Data Exchange (ETDEWEB)

    Saunders, Will [Australian Astron. Observ.; Gillingham, Peter [Australian Astron. Observ.; Smith, Greg [Australian Astron. Observ.; Kent, Steve [Fermilab; Doel, Peter [University Coll. London


    Wide-Field Corrector designs are presented for the Blanco and Mayall telescopes, the CFHT and the AAT. The designs are Terezibh-style, with 5 or 6 lenses, and modest negative optical power. They have 2.2-3 degree fields of view, with curved and telecentric focal surfaces suitable for fiber spectroscopy. Some variants also allow wide-field imaging, by changing the last WFC element. Apart from the adaptation of the Terebizh design for spectroscopy, the key feature is a new concept for a 'Compensating Lateral Atmospheric Dispersion Corrector', with two of the lenses being movable laterally by small amounts. This provides excellent atmospheric dispersion correction, without any additional surfaces or absorption. A novel and simple mechanism for providing the required lens motions is proposed, which requires just 3 linear actuators for each of the two moving lenses.

  9. A wide-FoV athermalized infrared imaging system with a two-element lens (United States)

    Feng, Bin; Shi, Zelin; Zhao, Yaohong; Liu, Haizheng; Liu, Li


    For infrared imaging systems to achieve wide field of view (FoV), wide operating temperature and low weight, this work designs a wide-FoV athermalized infrared imaging system (AIIS) with a two-element lens. Its principle, design, manufacture, measurement and performance validation are successively discussed. The two-element lens contains four surfaces, where three aspheric surfaces are introduced to reduce optical off-axis aberrations and a cubic surface is introduced to achieve athermalization. The key coding mask containing an aspheric surface and a cubic surface is manufactured by nano-metric machining of ion implanted material (NiIM). Experimental results validate that our wide-FoV wavefront coding AIIS has a full FoV of 26.10° and an operating temperature over -20 °C to +70 °C.

  10. Field free line magnetic particle imaging

    CERN Document Server

    Erbe, Marlitt


    Marlitt Erbe provides a detailed introduction into the young research field of Magnetic Particle Imaging (MPI) and field free line (FFL) imaging in particular. She derives a mathematical description of magnetic field generation for FFL imaging in MPI. To substantiate the simulation studies on magnetic FFL generation with a proof-of-concept, the author introduces the FFL field demonstrator, which provides the world's first experimentally generated rotated and translated magnetic FFL field complying with the requirements for FFL reconstruction. Furthermore, she proposes a scanner design of consi

  11. An iterative method for the computation of nonlinear, wide-angle, pulsed acoustic fields of medical diagnostic transducers

    NARCIS (Netherlands)

    Huijssen, J.; Verweij, M.D.


    The development and optimization of medical ultrasound transducers and imaging modalities require a computational method that accurately predicts the nonlinear acoustic pressure field. A prospective method should provide the wide-angle, pulsed field emitted by an arbitrary planar source distribution

  12. Wide-Field Astronomical Surveys in the Next Decade

    Energy Technology Data Exchange (ETDEWEB)

    Strauss, Michael A.; /Princeton U.; Tyson, J.Anthony; /UC, Davis; Anderson, Scott F.; /Washington U., Seattle, Astron. Dept.; Axelrod, T.S.; /LSST Corp.; Becker, Andrew C.; /Washington U., Seattle, Astron. Dept.; Bickerton, Steven J.; /Princeton U.; Blanton, Michael R.; /New York U.; Burke, David L.; /SLAC; Condon, J.J.; /NRAO, Socorro; Connolly, A.J.; /Washington U., Seattle, Astron. Dept.; Cooray, Asantha R.; /UC, Irvine; Covey, Kevin R.; /Harvard U.; Csabai, Istvan; /Eotvos U.; Ferguson, Henry C.; /Baltimore, Space Telescope Sci.; Ivezic, Zeljko; /Washington U., Seattle, Astron. Dept.; Kantor, Jeffrey; /LSST Corp.; Kent, Stephen M.; /Fermilab; Knapp, G.R.; /Princeton U.; Myers, Steven T.; /NRAO, Socorro; Neilsen, Eric H., Jr.; /Fermilab; Nichol, Robert C.; /Portsmouth U., ICG /Harish-Chandra Res. Inst. /Caltech, IPAC /Potsdam, Max Planck Inst. /Harvard U. /Hawaii U. /UC, Berkeley, Astron. Dept. /Baltimore, Space Telescope Sci. /NOAO, Tucson /Carnegie Mellon U. /Chicago U., Astron. Astrophys. Ctr.


    Wide-angle surveys have been an engine for new discoveries throughout the modern history of astronomy, and have been among the most highly cited and scientifically productive observing facilities in recent years. This trend is likely to continue over the next decade, as many of the most important questions in astrophysics are best tackled with massive surveys, often in synergy with each other and in tandem with the more traditional observatories. We argue that these surveys are most productive and have the greatest impact when the data from the surveys are made public in a timely manner. The rise of the 'survey astronomer' is a substantial change in the demographics of our field; one of the most important challenges of the next decade is to find ways to recognize the intellectual contributions of those who work on the infrastructure of surveys (hardware, software, survey planning and operations, and databases/data distribution), and to make career paths to allow them to thrive.

  13. Wide-Field Astronomical Surveys in the Next Decade

    Energy Technology Data Exchange (ETDEWEB)

    Strauss, Michael A.; /Princeton U.; Tyson, J.Anthony; /UC, Davis; Anderson, Scott F.; /Washington U., Seattle, Astron. Dept.; Axelrod, T.S.; /LSST Corp.; Becker, Andrew C.; /Washington U., Seattle, Astron. Dept.; Bickerton, Steven J.; /Princeton U.; Blanton, Michael R.; /New York U.; Burke, David L.; /SLAC; Condon, J.J.; /NRAO, Socorro; Connolly, A.J.


    Wide-angle surveys have been an engine for new discoveries throughout the modern history of astronomy, and have been among the most highly cited and scientifically productive observing facilities in recent years. This trend is likely to continue over the next decade, as many of the most important questions in astrophysics are best tackled with massive surveys, often in synergy with each other and in tandem with the more traditional observatories. We argue that these surveys are most productive and have the greatest impact when the data from the surveys are made public in a timely manner. The rise of the 'survey astronomer' is a substantial change in the demographics of our field; one of the most important challenges of the next decade is to find ways to recognize the intellectual contributions of those who work on the infrastructure of surveys (hardware, software, survey planning and operations, and databases/data distribution), and to make career paths to allow them to thrive.

  14. Rotation Periods of Wide Binaries in the Kepler Field (United States)

    Janes, K. A.


    In a search of proper motion catalogs for common proper motion stars in the field of the Kepler spacecraft I identified 93 likely binary systems. A comparison of their rotation periods is a test of the gyrochronology concept. To find their periods I calculated the autocorrelation function (ACF) of the Kepler mission photometry for each star. In most systems for which good periods can be found, the cooler star has a longer period than the hotter component, in general agreement with models. However, there is a wide range in the gradients of lines connecting binary pairs in a period-color diagram. Furthermore, near the solar color, only a few stars have longer periods than the Sun, suggesting that they, and their cooler companions, are not much older than the Sun. In addition, there is an apparent gap at intermediate periods in the period distribution of the late K and early M stars. Either star formation in this direction has been variable, or stars evolve in period at a non-uniform rate, or some stars evolve more rapidly than others at the same mass. Finally, using the ACF as a measure of the activity level, I found that while the F, G, and early K stars become less active as their periods increase, there is no correlation between period and activity for the mid K to early M stars.

  15. Water-Immersible MEMS scanning mirror designed for wide-field fast-scanning photoacoustic microscopy (United States)

    Yao, Junjie; Huang, Chih-Hsien; Martel, Catherine; Maslov, Konstantin I.; Wang, Lidai; Yang, Joon-Mo; Gao, Liang; Randolph, Gwendalyn; Zou, Jun; Wang, Lihong V.


    By offering images with high spatial resolution and unique optical absorption contrast, optical-resolution photoacoustic microscopy (OR-PAM) has gained increasing attention in biomedical research. Recent developments in OR-PAM have improved its imaging speed, but have sacrificed either the detection sensitivity or field of view or both. We have developed a wide-field fast-scanning OR-PAM by using a water-immersible MEMS scanning mirror (MEMS-ORPAM). Made of silicon with a gold coating, the MEMS mirror plate can reflect both optical and acoustic beams. Because it uses an electromagnetic driving force, the whole MEMS scanning system can be submerged in water. In MEMS-ORPAM, the optical and acoustic beams are confocally configured and simultaneously steered, which ensures uniform detection sensitivity. A B-scan imaging speed as high as 400 Hz can be achieved over a 3 mm scanning range. A diffraction-limited lateral resolution of 2.4 μm in water and a maximum imaging depth of 1.1 mm in soft tissue have been experimentally determined. Using the system, we imaged the flow dynamics of both red blood cells and carbon particles in a mouse ear in vivo. By using Evans blue dye as the contrast agent, we also imaged the flow dynamics of lymphatic vessels in a mouse tail in vivo. The results show that MEMS-OR-PAM could be a powerful tool for studying highly dynamic and time-sensitive biological phenomena.

  16. Stray-field-induced Faraday contributions in wide-field Kerr microscopy and -magnetometry

    Energy Technology Data Exchange (ETDEWEB)

    Markó, D.; Soldatov, I. [Leibniz Institute for Solid State and Materials Research (IFW) Dresden, Institute for Metallic Materials, PO 270116, D-01171 Dresden (Germany); Dresden University of Technology, Institute for Materials Science, D-01062 Dresden (Germany); Tekielak, M. [Institute of Experimental Physics, University of Bialystok, Lipowa 41, Bialystok 15-424 Poland (Poland); Schäfer, R., E-mail: [Leibniz Institute for Solid State and Materials Research (IFW) Dresden, Institute for Metallic Materials, PO 270116, D-01171 Dresden (Germany); Dresden University of Technology, Institute for Materials Science, D-01062 Dresden (Germany)


    The magnetic domain contrast in wide-field Kerr microscopy on bulk specimens can be substantially distorted by non-linear, field-dependent Faraday rotations in the objective lens that are caused by stray-field components emerging from the specimen. These Faraday contributions, which were detected by Kerr-magnetometry on grain-oriented iron–silicon steel samples, are thoroughly elaborated and characterized. They express themselves as a field-dependent gray-scale offset to the domain contrast and in highly distorted surface magnetization curves if optically measured in a wide field Kerr microscope. An experimental method to avoid such distortions is suggested. In the course of these studies, a low-permeability part in the surface magnetization loop of slightly misoriented (110)-surfaces in iron–silicon sheets was discovered that is attributed to demagnetization effects in direction perpendicular to the sheet surface. - Highlights: • Magnetizing a finite sample in a Kerr microscope leads to sample-generated stray-fields. • They cause non-linear, field- and position-dependent Faraday rotations in the objective. • This leads to a modulation of the Kerr contrast and to distorted MOKE loops. • A method to compensate these Faraday rotations is presented.

  17. Field of Particle Filters Image Inpainting

    DEFF Research Database (Denmark)

    Cuzol, Anne; Pedersen, Kim Steenstrup; Nielsen, Mads


    We present a novel algorithm for solving the image inpainting problem based on a field of locally interacting particle filters. Image inpainting, also known as image completion, is concerned with the problem of filling image regions with new visually plausible data. In order to avoid the difficulty...... of solving the problem globally for the region to be inpainted, we introduce a field of local particle filters. The states of the particle filters are image patches. Global consistency is enforced by a Markov random field image model which connects neighbouring particle filters. The benefit of using locally...... interacting particle filters is that several competing hypotheses on inpainting solutions are kept active, allowing the method to provide globally consistent solutions on problems where other local methods may fail. We provide examples of applications of the developed method. Keywords: Inpainting · Image...

  18. THz Imaging by a Wide-band Compact FEL

    CERN Document Server

    Uk Jeong Young; Cheol Lee Byung; Hee-Park, S


    We have developed a laboratory-scale users facility with a compact THz FEL. The FEL operates in the wide wavelength range of 100–1200 μm, which corresponds to 0.3-3 THz. THz radiation from the FEL shows well collimated Gaussian spatial distribution and narrow spectral width of 0.3 μm, which is Fourier transform limited by the estimated pulse duration of 20 ps. The main application of the FEL is THz imaging for bio-medical researches. We are developing THz imaging techniques by 2-D scanning, single pulse capturing with the electro-optic method, and 3-D holography. High power, coherent, and pulsed feature of the FEL radiation is expected to show much better performance in advanced THz imaging of 3-D tomography by comparing with incoherent and weak THz sources. By controlling the optical delay between reference beam and scattered light from an object, we can get its 3-D tomography by the holograms. The coherent and pulse length of the FEL beam is measured to be 3-6 mm. In this paper we will show a...

  19. Magnetic Resonance Imaging at Ultrahigh Fields (United States)

    Uğurbil, Kamil


    Since the introduction of 4 T human systems in three academic laboratories circa 1990, rapid progress in imaging and spectroscopy studies in humans at 4 T and animal model systems at 9.4 T have led to the introduction of 7 T and higher magnetic fields for human investigation at about the turn of the century. Work conducted on these platforms has demonstrated the existence of significant advantages in SNR and biological information content at these ultrahigh fields, as well as the presence of numerous challenges. Primary difference from lower fields is the deviation from the near field regime; at the frequencies corresponding to hydrogen resonance conditions at ultrahigh fields, the RF is characterized by attenuated traveling waves in the human body, which leads to image nonuniformities for a given sample-coil configuration because of interferences. These nonuniformities were considered detrimental to the progress of imaging at high field strengths. However, they are advantageous for parallel imaging for signal reception and parallel transmission, two critical technologies that account, to a large extend, for the success of ultrahigh fields. With these technologies, and improvements in instrumentation and imaging methods, ultra-high fields have provided unprecedented gains in imaging of brain function and anatomy, and started to make inroads into investigation of the human torso and extremities. As extensive as they are, these gains still constitute a prelude to what is to come given the increasingly larger effort committed to ultrahigh field research and development of ever better instrumentation and techniques. PMID:24686229

  20. Clinical assessment of human breast cancer margins with wide-field optical coherence micro-elastography (Conference Presentation) (United States)

    Allen, Wes M.; Chin, Lixin; Wijesinghe, Philip; Kirk, Rodney W.; Latham, Bruce; Sampson, David D.; Saunders, Christobel M.; Kennedy, Brendan F.


    Breast cancer has the second highest mortality rate of all cancers in females. Surgical excision of malignant tissue forms a central component of breast-conserving surgery (BCS) procedures. Incomplete excision of malignant tissue is a major issue in BCS with typically 20 - 30% cases requiring a second surgical procedure due to postoperative detection of tumor in the margin. A major challenge for surgeons during BCS is the lack of effective tools to assess the surgical margin intraoperatively. Such tools would enable the surgeon to more effectively remove all tumor during the initial surgery, hence reducing re-excision rates. We report advances in the development of a new tool, optical coherence micro-elastography, which forms images, known as elastograms, based on mechanical contrast within the tissue. We demonstrate the potential of this technique to increase contrast between malignant tumor and healthy stroma in elastograms over OCT images. We demonstrate a key advance toward clinical translation by conducting wide-field imaging in intraoperative time frames with a wide-field scanning system, acquiring mosaicked elastograms with overall dimensions of 50 × 50 mm, large enough to image an entire face of most lumpectomy specimens. We describe this wide-field imaging system, and demonstrate its operation by presenting wide-field optical coherence tomography images and elastograms of a tissue mimicking silicone phantom and a number of representative freshly excised human breast specimens. Our results demonstrate the feasibility of scanning large areas of lumpectomies, which is an important step towards practical intraoperative margin assessment.

  1. Wide-Field Fundus Autofluorescence for Retinitis Pigmentosa and Cone/Cone-Rod Dystrophy. (United States)

    Oishi, Akio; Oishi, Maho; Ogino, Ken; Morooka, Satoshi; Yoshimura, Nagahisa


    Retinitis pigmentosa and cone/cone-rod dystrophy are inherited retinal diseases characterized by the progressive loss of rod and/or cone photoreceptors. To evaluate the status of rod/cone photoreceptors and visual function, visual acuity and visual field tests, electroretinogram, and optical coherence tomography are typically used. In addition to these examinations, fundus autofluorescence (FAF) has recently garnered attention. FAF visualizes the intrinsic fluorescent material in the retina, which is mainly lipofuscin contained within the retinal pigment epithelium. While conventional devices offer limited viewing angles in FAF, the recently developed Optos machine enables recording of wide-field FAF. With wide-field analysis, an association between abnormal FAF areas and visual function was demonstrated in retinitis pigmentosa and cone-rod dystrophy. In addition, the presence of "patchy" hypoautofluorescent areas was found to be correlated with symptom duration. Although physicians should be cautious when interpreting wide-field FAF results because the peripheral parts of the image are magnified significantly, this examination method provides previously unavailable information.

  2. Near-field acoustic imaging based on Laplacian sparsity

    DEFF Research Database (Denmark)

    Fernandez Grande, Efren; Daudet, Laurent


    We present a sound source identification method for near-field acoustic imaging of extended sources. The methodology is based on a wave superposition method (or equivalent source method) that promotes solutions with sparse higher order spatial derivatives. Instead of promoting direct sparsity......, and the validity of the wave extrapolation used for the reconstruction is examined. It is shown that this methodology can overcome conventional limits of spatial sampling, and is therefore valid for wide-band acoustic imaging of extended sources....

  3. A small animal time-resolved optical tomography platform using wide-field excitation (United States)

    Venugopal, Vivek

    Small animal imaging plays a critical role in present day biomedical research by filling an important gap in the translation of research from the bench to the bedside. Optical techniques constitute an emerging imaging modality which have tremendous potential in preclinical applications. Optical imaging methods are capable of non-invasive assessment of the functional and molecular characteristics of biological tissue. The three-dimensional optical imaging technique, referred to as diffuse optical tomography, provides an approach for the whole-body imaging of small animal models and can provide volumetric maps of tissue functional parameters (e.g. blood volume, oxygen saturation etc.) and/or provide 3D localization and quantification of fluorescence-based molecular markers in vivo. However, the complex mathematical reconstruction problem associated with optical tomography and the cumbersome instrumental designs limits its adoption as a high-throughput quantitative whole-body imaging modality in current biomedical research. The development of new optical imaging paradigms is thus necessary for a wide-acceptance of this new technology. In this thesis, the design, development, characterization and optimization of a small animal optical tomography system is discussed. Specifically, the platform combines a highly sensitive time-resolved imaging paradigm with multi-spectral excitation capability and CCD-based detection to provide a system capable of generating spatially, spectrally and temporally dense measurement datasets. The acquisition of such data sets however can take long and translate to often unrealistic acquisition times when using the classical point source based excitation scheme. The novel approach in the design of this platform is the adoption of a wide-field excitation scheme which employs extended excitation sources and in the process allows an estimated ten-fold reduction in the acquisition time. The work described herein details the design of the imaging

  4. Efficient Terahertz Wide-Angle NUFFT-Based Inverse Synthetic Aperture Imaging Considering Spherical Wavefront

    Directory of Open Access Journals (Sweden)

    Jingkun Gao


    Full Text Available An efficient wide-angle inverse synthetic aperture imaging method considering the spherical wavefront effects and suitable for the terahertz band is presented. Firstly, the echo signal model under spherical wave assumption is established, and the detailed wavefront curvature compensation method accelerated by 1D fast Fourier transform (FFT is discussed. Then, to speed up the reconstruction procedure, the fast Gaussian gridding (FGG-based nonuniform FFT (NUFFT is employed to focus the image. Finally, proof-of-principle experiments are carried out and the results are compared with the ones obtained by the convolution back-projection (CBP algorithm. The results demonstrate the effectiveness and the efficiency of the presented method. This imaging method can be directly used in the field of nondestructive detection and can also be used to provide a solution for the calculation of the far-field RCSs (Radar Cross Section of targets in the terahertz regime.

  5. Electric potential and electric field imaging (United States)

    Generazio, E. R.


    The technology and methods for remote quantitative imaging of electrostatic potentials and electrostatic fields in and around objects and in free space is presented. Electric field imaging (EFI) technology may be applied to characterize intrinsic or existing electric potentials and electric fields, or an externally generated electrostatic field made be used for "illuminating" volumes to be inspected with EFI. The baseline sensor technology (e-Sensor) and its construction, optional electric field generation (quasi-static generator), and current e-Sensor enhancements (ephemeral e-Sensor) are discussed. Demonstrations for structural, electronic, human, and memory applications are shown. This new EFI capability is demonstrated to reveal characterization of electric charge distribution creating a new field of study embracing areas of interest including electrostatic discharge (ESD) mitigation, crime scene forensics, design and materials selection for advanced sensors, dielectric morphology of structures, tether integrity, organic molecular memory, and medical diagnostic and treatment efficacy applications such as cardiac polarization wave propagation and electromyography imaging.

  6. Proton imaging of stochastic magnetic fields (United States)

    Bott, A. F. A.; Graziani, C.; Tzeferacos, P.; White, T. G.; Lamb, D. Q.; Gregori, G.; Schekochihin, A. A.


    Recent laser-plasma experiments (Fox et al., Phys. Rev. Lett., vol. 111, 2013, 225002; Huntington et al., Nat. Phys., vol. 11(2), 2015, 173-176 Tzeferacos et al., Phys. Plasmas, vol. 24(4), 2017a, 041404; Tzeferacos et al., 2017b, arXiv:1702.03016 [physics.plasm-ph]) report the existence of dynamically significant magnetic fields, whose statistical characterisation is essential for a complete understanding of the physical processes these experiments are attempting to investigate. In this paper, we show how a proton-imaging diagnostic can be used to determine a range of relevant magnetic-field statistics, including the magnetic-energy spectrum. To achieve this goal, we explore the properties of an analytic relation between a stochastic magnetic field and the image-flux distribution created upon imaging that field. This `Kugland image-flux relation' was previously derived (Kugland et al., Rev. Sci. Instrum. vol. 83(10), 2012, 101301) under simplifying assumptions typically valid in actual proton-imaging set-ups. We conclude that, as with regular electromagnetic fields, features of the beam's final image-flux distribution often display a universal character determined by a single, field-scale dependent parameter - the contrast parameter s/{\\mathcal{M}}lB$ - which quantifies the relative size of the correlation length B$ of the stochastic field, proton displacements s$ due to magnetic deflections and the image magnification . For stochastic magnetic fields, we establish the existence of four contrast regimes, under which proton-flux images relate to their parent fields in a qualitatively distinct manner. These are linear, nonlinear injective, caustic and diffusive. The diffusive regime is newly identified and characterised. The nonlinear injective regime is distinguished from the caustic regime in manifesting nonlinear behaviour, but as in the linear regime, the path-integrated magnetic field experienced by the beam can be extracted uniquely. Thus, in the linear and

  7. Improved iris localization by using wide and narrow field of view cameras for iris recognition (United States)

    Kim, Yeong Gon; Shin, Kwang Yong; Park, Kang Ryoung


    Biometrics is a method of identifying individuals by their physiological or behavioral characteristics. Among other biometric identifiers, iris recognition has been widely used for various applications that require a high level of security. When a conventional iris recognition camera is used, the size and position of the iris region in a captured image vary according to the X, Y positions of a user's eye and the Z distance between a user and the camera. Therefore, the searching area of the iris detection algorithm is increased, which can inevitably decrease both the detection speed and accuracy. To solve these problems, we propose a new method of iris localization that uses wide field of view (WFOV) and narrow field of view (NFOV) cameras. Our study is new as compared to previous studies in the following four ways. First, the device used in our research acquires three images, one each of the face and both irises, using one WFOV and two NFOV cameras simultaneously. The relation between the WFOV and NFOV cameras is determined by simple geometric transformation without complex calibration. Second, the Z distance (between a user's eye and the iris camera) is estimated based on the iris size in the WFOV image and anthropometric data of the size of the human iris. Third, the accuracy of the geometric transformation between the WFOV and NFOV cameras is enhanced by using multiple matrices of the transformation according to the Z distance. Fourth, the searching region for iris localization in the NFOV image is significantly reduced based on the detected iris region in the WFOV image and the matrix of geometric transformation corresponding to the estimated Z distance. Experimental results showed that the performance of the proposed iris localization method is better than that of conventional methods in terms of accuracy and processing time.

  8. Programmable LED-based integrating sphere light source for wide-field fluorescence microscopy. (United States)

    Rehman, Aziz Ul; Anwer, Ayad G; Goldys, Ewa M


    Wide-field fluorescence microscopy commonly uses a mercury lamp, which has limited spectral capabilities. We designed and built a programmable integrating sphere light (PISL) source which consists of nine LEDs, light-collecting optics, a commercially available integrating sphere and a baffle. The PISL source is tuneable in the range 365-490nm with a uniform spatial profile and a sufficient power at the objective to carry out spectral imaging. We retrofitted a standard fluorescence inverted microscope DM IRB (Leica) with a PISL source by mounting it together with a highly sensitive low- noise CMOS camera. The capabilities of the setup have been demonstrated by carrying out multispectral autofluorescence imaging of live BV2 cells. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Picosecond wide-field time-correlated single photon counting fluorescence microscopy with a delay line anode detector

    Energy Technology Data Exchange (ETDEWEB)

    Hirvonen, Liisa M.; Le Marois, Alix; Suhling, Klaus, E-mail: [Department of Physics, King' s College London, Strand, London WC2R 2LS (United Kingdom); Becker, Wolfgang; Smietana, Stefan [Becker & Hickl GmbH, Nahmitzer Damm 30, 12277 Berlin (Germany); Milnes, James; Conneely, Thomas [Photek Ltd., 26 Castleham Rd, Saint Leonards-on-Sea TN38 9NS (United Kingdom); Jagutzki, Ottmar [Institut für Kernphysik, Max-von-Laue-Str. 1, 60438 Frankfurt (Germany)


    We perform wide-field time-correlated single photon counting-based fluorescence lifetime imaging (FLIM) with a crossed delay line anode image intensifier, where the pulse propagation time yields the photon position. This microchannel plate-based detector was read out with conventional fast timing electronics and mounted on a fluorescence microscope with total internal reflection (TIR) illumination. The picosecond time resolution of this detection system combines low illumination intensity of microwatts with wide-field data collection. This is ideal for fluorescence lifetime imaging of cell membranes using TIR. We show that fluorescence lifetime images of living HeLa cells stained with membrane dye di-4-ANEPPDHQ exhibit a reduced lifetime near the coverslip in TIR compared to epifluorescence FLIM.

  10. Imaging electric field dynamics with graphene optoelectronics. (United States)

    Horng, Jason; Balch, Halleh B; McGuire, Allister F; Tsai, Hsin-Zon; Forrester, Patrick R; Crommie, Michael F; Cui, Bianxiao; Wang, Feng


    The use of electric fields for signalling and control in liquids is widespread, spanning bioelectric activity in cells to electrical manipulation of microstructures in lab-on-a-chip devices. However, an appropriate tool to resolve the spatio-temporal distribution of electric fields over a large dynamic range has yet to be developed. Here we present a label-free method to image local electric fields in real time and under ambient conditions. Our technique combines the unique gate-variable optical transitions of graphene with a critically coupled planar waveguide platform that enables highly sensitive detection of local electric fields with a voltage sensitivity of a few microvolts, a spatial resolution of tens of micrometres and a frequency response over tens of kilohertz. Our imaging platform enables parallel detection of electric fields over a large field of view and can be tailored to broad applications spanning lab-on-a-chip device engineering to analysis of bioelectric phenomena.

  11. Wide Field Coverage for Juno (WFCJ): Jupiter's 2D Wind Field and Cloud Structure (United States)

    Wong, Michael


    Juno will take novel measurements in the jovian system during HST Cycles 23, 24, and 25. This proposal supports Juno's neutral atmospheric investigation, which includes measurements with an IR imager/spectrometer (JIRAM) and the Microwave Radiometer (MWR). Both will achieve high spatial resolution as the orbiter swoops past Jupiter, in between the radiation belts and the cloud tops. But instrument fields of view are small compared to the planet, so HST observations would provide valuable context and complementary information.We propose to measure Jupiter's 2D wind field, as well as UV/optical cloud colors (and their evolution). We will measure winds using sets of global maps that cover two of Juno's perijove passes, characterizing the time-varying dynamics of waves, jets, vortices, and storms. The remaining perijove passes will be covered by snapshot (1-orbit) visits, sufficient to characterize feature morphology along each Juno track at high resolution. These observations will give crucial context for MWR observations and enable more precise retrievals from MWR data. Earth-based support is particularly important for Juno, due to its highly eccentric orbit and specialized instrumentation. WFC3/UVIS imaging can play an important role in the effort, since no other facility can obtain precise 2D wind fields and UV/optical photometry at high spatial resolution. Without the HST component of this campaign, key dynamical constraints will be missing.

  12. The KIDROP model of combining strategies for providing retinopathy of prematurity screening in underserved areas in India using wide-field imaging, tele-medicine, non-physician graders and smart phone reporting

    Directory of Open Access Journals (Sweden)

    Anand Vinekar


    Full Text Available Aim: To report the Karnataka Internet Assisted Diagnosis of Retinopathy of Prematurity (KIDROP program for retinopathy of prematurity (ROP screening in underserved rural areas using an indigenously developed tele-ROP model. Materials and Methods: KIDROP currently provides ROP screening and treatment services in three zones and 81 neonatal units in Karnataka, India. Technicians were trained to use a portable Retcam Shuttle (Clarity, USA and validated against ROP experts performing indirect ophthalmoscopy. An indigenously developed 20-point score (STAT score graded their ability (Level I to III to image and decide follow-up based on a three-way algorithm. Images were also uploaded on a secure tele-ROP platform and accessed and reported by remote experts on their smart phones (iPhone, Apple. Results: 6339 imaging sessions of 1601 infants were analyzed. A level III technician agreed with 94.3% of all expert decisions. The sensitivity, specificity, positive predictive value and negative predictive value for treatment grade disease were 95.7, 93.2, 81.5 and 98.6 respectively. The kappa for technicians to decide discharge of babies was 0.94 (P < 0.001. Only 0.4% of infants needing treatment were missed.The kappa agreement of experts reporting on the iPhone vs Retcam for treatment requiring and mild ROP were 0.96 and 0.94 (P < 0.001 respectively. Conclusions: This is the first and largest real-world program to employ accredited non-physicians to grade and report ROP. The KIDROP tele-ROP model demonstrates that ROP services can be delivered to the outreach despite lack of specialists and may be useful in other middle-income countries with similar demographics.

  13. Light field analysis for modeling image formation. (United States)

    Liang, Chia-Kai; Shih, Yi-Chang; Chen, Homer H


    Image formation is traditionally described by a number of individual models, one for each specific effect in the image formation process. However, it is difficult to aggregate the effects by concatenating such individual models. In this paper, we apply light transport analysis to derive a unified image formation model that represents the radiance along a light ray as a 4-D light field signal and physical phenomena such as lens refraction and blocking as linear transformations or modulations of the light field. This unified mathematical framework allows the entire image formation process to be elegantly described by a single equation. It also allows most geometric and photometric effects of imaging, including perspective transformation, defocus blur, and vignetting, to be represented in both 4-D primal and dual domains. The result matches that of traditional models. Generalizations and applications of this theoretic framework are discussed.

  14. Wide-Field Multi-Parameter FLIM: Long-Term Minimal Invasive Observation of Proteins in Living Cells.

    NARCIS (Netherlands)

    Vitali, M.; Picazo, F.; Prokazov, Y.; Duci, A.; Turbin, E.; Götze, C.; Llopis, J.; Hartig, R.; Visser, A.J.W.G.; Zuschratter, W.


    Time-domain Fluorescence Lifetime Imaging Microscopy (FLIM) is a remarkable tool to monitor the dynamics of fluorophore-tagged protein domains inside living cells. We propose a Wide-Field Multi-Parameter FLIM method (WFMP-FLIM) aimed to monitor continuously living cells under minimum light intensity

  15. Reducing Field Distortion in Magnetic Resonance Imaging (United States)

    Eom, Byeong Ho; Penanen, Konstantin; Hahn, Inseob


    A concept for a magnetic resonance imaging (MRI) system that would utilize a relatively weak magnetic field provides for several design features that differ significantly from the corresponding features of conventional MRI systems. Notable among these features are a magnetic-field configuration that reduces (relative to the conventional configuration) distortion and blurring of the image, the use of a superconducting quantum interference device (SQUID) magnetometer as the detector, and an imaging procedure suited for the unconventional field configuration and sensor. In a typical application of MRI, a radio-frequency pulse is used to excite precession of the magnetic moments of protons in an applied magnetic field, and the decaying precession is detected for a short time following the pulse. The precession occurs at a resonance frequency proportional to the strengths of the magnetic field and the proton magnetic moment. The magnetic field is configured to vary with position in a known way; hence, by virtue of the aforesaid proportionality, the resonance frequency varies with position in a known way. In other words, position is encoded as resonance frequency. MRI using magnetic fields weaker than those of conventional MRI offers several advantages, including cheaper and smaller equipment, greater compatibility with metallic objects, and higher image quality because of low susceptibility distortion and enhanced spin-lattice-relaxation- time contrast. SQUID MRI is being developed into a practical MRI method for applied magnetic flux densities of the order of only 100 T

  16. The Receiver System for the Ooty Wide Field Array

    Indian Academy of Sciences (India)

    OWFA is designed to retain the benefits of equatorial mount, continuous 9-hour tracking ability and large collecting area of the legacy telescope and use of modern digital techniques to enhance the instantaneous field-of-view by more than an order of magnitude. OWFA has unique advantages for contemporary ...

  17. Observing GRBs with the LOFT Wide Field Monitor

    DEFF Research Database (Denmark)

    Brandt, Søren; Hernanz, M.; Feroci, M.


    field of view and good energy resolution of GRBs and X-ray flashes. The WFM will be able to detect ~150 gamma ray bursts per year, and a burst alert system will enable the distribution of ~100 GRB positions per year with a ~1...

  18. Wide Band Low Noise Love Wave Magnetic Field Sensor System. (United States)

    Kittmann, Anne; Durdaut, Phillip; Zabel, Sebastian; Reermann, Jens; Schmalz, Julius; Spetzler, Benjamin; Meyners, Dirk; Sun, Nian X; McCord, Jeffrey; Gerken, Martina; Schmidt, Gerhard; Höft, Michael; Knöchel, Reinhard; Faupel, Franz; Quandt, Eckhard


    We present a comprehensive study of a magnetic sensor system that benefits from a new technique to substantially increase the magnetoelastic coupling of surface acoustic waves (SAW). The device uses shear horizontal acoustic surface waves that are guided by a fused silica layer with an amorphous magnetostrictive FeCoSiB thin film on top. The velocity of these so-called Love waves follows the magnetoelastically-induced changes of the shear modulus according to the magnetic field present. The SAW sensor is operated in a delay line configuration at approximately 150 MHz and translates the magnetic field to a time delay and a related phase shift. The fundamentals of this sensor concept are motivated by magnetic and mechanical simulations. They are experimentally verified using customized low-noise readout electronics. With an extremely low magnetic noise level of ≈100 pT/[Formula: see text], a bandwidth of 50 kHz and a dynamic range of 120 dB, this magnetic field sensor system shows outstanding characteristics. A range of additional measures to further increase the sensitivity are investigated with simulations.


    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Jungmi; Tamura, Motohide; Kusakabe, Nobuhiko [Department of Astronomy, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Hough, James H. [Centre for Astrophysics Research, University of Hertfordshire, College Lane, Hatfield AL10 9AB (United Kingdom); Nakajima, Yasushi [Center of Information and Communication Technology, Hitotsubashi University, 2-1 Naka, Kunitachi, Tokyo 186-8601 (Japan); Nishiyama, Shogo [Miyagi University of Education, Sendai 980-0845 (Japan); Nagata, Tetsuya [Department of Astronomy, Kyoto University, Kyoto 606-8502 (Japan); Kandori, Ryo, E-mail: [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan)


    We conducted wide and deep simultaneous JHK{sub s}-band imaging polarimetry of the ρ Ophiuchi cloud complex. Aperture polarimetry in the JHK{sub s} band was conducted for 2136 sources in all three bands, of which 322 sources have significant polarizations in all the JHK{sub s} bands and have been used for a discussion of the core magnetic fields. There is a positive correlation between degrees of polarization and H − K{sub s} color up to H − K{sub s} ≈ 3.5. The magnetic field structures in the core region are revealed up to at least A{sub V} ≈ 47 mag and are unambiguously defined in each sub-region (core) of Oph-A, Oph-B, Oph-C, Oph-E, Oph-F, and Oph-AC. Their directions, degrees of polarization, and polarization efficiencies differ but their changes are gradual; thus, the magnetic fields appear to be connected from core to core, rather than as a simple overlap of the different cloud core components. Comparing our results with the large-scale field structures obtained from previous optical polarimetric studies, we suggest that the magnetic field structures in the core were distorted by the cluster formation in this region, which may have been induced by shock compression due to wind/radiation from the Scorpius–Centaurus association.

  20. Mapping absolute tissue endogenous fluorophore concentrations with chemometric wide-field fluorescence microscopy (United States)

    Xu, Zhang; Reilley, Michael; Li, Run; Xu, Min


    We report chemometric wide-field fluorescence microscopy for imaging the spatial distribution and concentration of endogenous fluorophores in thin tissue sections. Nonnegative factorization aided by spatial diversity is used to learn both the spectral signature and the spatial distribution of endogenous fluorophores from microscopic fluorescence color images obtained under broadband excitation and detection. The absolute concentration map of individual fluorophores is derived by comparing the fluorescence from "pure" fluorophores under the identical imaging condition following the identification of the fluorescence species by its spectral signature. This method is then demonstrated by characterizing the concentration map of endogenous fluorophores (including tryptophan, elastin, nicotinamide adenine dinucleotide, and flavin adenine dinucleotide) for lung tissue specimens. The absolute concentrations of these fluorophores are all found to decrease significantly from normal, perilesional, to cancerous (squamous cell carcinoma) tissue. Discriminating tissue types using the absolute fluorophore concentration is found to be significantly more accurate than that achievable with the relative fluorescence strength. Quantification of fluorophores in terms of the absolute concentration map is also advantageous in eliminating the uncertainties due to system responses or measurement details, yielding more biologically relevant data, and simplifying the assessment of competing imaging approaches.

  1. Imaging interferometry to measure surface rotation field

    DEFF Research Database (Denmark)

    Travaillot, Thomas; Dohn, Søren; Boisen, Anja


    This paper describes a polarized-light imaging interferometer to measure the rotation field of reflecting surfaces. This setup is based on a homemade prism featuring a birefringence gradient. The arrangement is presented before focusing on the homemade prism and its manufacturing process. The dep....... The dependence of the measured optical phase on the rotation of the surface is derived, thus highlighting the key parameters driving the sensitivity. The system’s capabilities are illustrated by imaging the rotation field at the surface of a tip-loaded polymer specimen.......This paper describes a polarized-light imaging interferometer to measure the rotation field of reflecting surfaces. This setup is based on a homemade prism featuring a birefringence gradient. The arrangement is presented before focusing on the homemade prism and its manufacturing process...

  2. Field Sampling from a Segmented Image

    CSIR Research Space (South Africa)

    Debba, Pravesh


    Full Text Available Image Debba, Stein, van der Meer, Carranza, Lucieer Objective Study Site Methods The ICM Algorithm Sampling Per Category Sample Size Per Category Fitness Function Per Category Simulated Annealing Per Category Results Experiment Case... Study Conclusions Field Sampling from a Segmented Image P. Debba1 A. Stein2 F.D. van der Meer2 E.J.M. Carranza2 A. Lucieer3 1The Council for Scientific and Industrial Research (CSIR), Logistics and Quantitative Methods, CSIR Built Environment, P...

  3. Wide field of view tabletop light field display based on piece-wise tracking and off-axis pickup (United States)

    Zhu, Yanhong; Sang, Xinzhu; Yu, Xunbo; Wang, Peng; Xing, Shujun; Chen, Duo; Yan, Binbin; Wang, Kuiru; Yu, Chongxiu


    A wide field of view (FOV) tabletop light field display (LFD) based on piece-wise tracking and off-axis pickup is presented to display the floating three-dimensional (3D) scene, which is 360°surrounding viewable. The demonstrated LFD is specially designed with an integral imaging display (IID) with 83 × 83 viewpoints and a full-parallax holographic functional screen (HFS). To improve the FOV, a piece-wise tracking based FOV enhancement method is proposed. The relationship between the viewing zone and the elemental images (EIs) is formulated. A ray-tracing based method using off-axis pickup instead of parallel pickup directly is adopted to render the 3D scene to EIs. Then the piece-wise tracking method of varying the viewing zone by placing the EIs according to the position of viewer is analyzed. The floating 3D scene with a FOV of 70° × 70°is experimentally demonstrated with a good 3D perception.

  4. Electric field imaging of single atoms (United States)

    Shibata, Naoya; Seki, Takehito; Sánchez-Santolino, Gabriel; Findlay, Scott D.; Kohno, Yuji; Matsumoto, Takao; Ishikawa, Ryo; Ikuhara, Yuichi


    In scanning transmission electron microscopy (STEM), single atoms can be imaged by detecting electrons scattered through high angles using post-specimen, annular-type detectors. Recently, it has been shown that the atomic-scale electric field of both the positive atomic nuclei and the surrounding negative electrons within crystalline materials can be probed by atomic-resolution differential phase contrast STEM. Here we demonstrate the real-space imaging of the (projected) atomic electric field distribution inside single Au atoms, using sub-Å spatial resolution STEM combined with a high-speed segmented detector. We directly visualize that the electric field distribution (blurred by the sub-Å size electron probe) drastically changes within the single Au atom in a shape that relates to the spatial variation of total charge density within the atom. Atomic-resolution electric field mapping with single-atom sensitivity enables us to examine their detailed internal and boundary structures.

  5. Electric field imaging of single atoms (United States)

    Shibata, Naoya; Seki, Takehito; Sánchez-Santolino, Gabriel; Findlay, Scott D.; Kohno, Yuji; Matsumoto, Takao; Ishikawa, Ryo; Ikuhara, Yuichi


    In scanning transmission electron microscopy (STEM), single atoms can be imaged by detecting electrons scattered through high angles using post-specimen, annular-type detectors. Recently, it has been shown that the atomic-scale electric field of both the positive atomic nuclei and the surrounding negative electrons within crystalline materials can be probed by atomic-resolution differential phase contrast STEM. Here we demonstrate the real-space imaging of the (projected) atomic electric field distribution inside single Au atoms, using sub-Å spatial resolution STEM combined with a high-speed segmented detector. We directly visualize that the electric field distribution (blurred by the sub-Å size electron probe) drastically changes within the single Au atom in a shape that relates to the spatial variation of total charge density within the atom. Atomic-resolution electric field mapping with single-atom sensitivity enables us to examine their detailed internal and boundary structures. PMID:28555629

  6. Digital enhancement of flow field images (United States)

    Kudlinski, Robert A.; Park, Stephen K.


    Most photographs of experimentally generated fluid flow fields have inherently poor photographic quality, specifically low contrast. Thus, there is a need to establish a process for quickly and accurately enhancing these photographs to provide improved versions for physical interpretation, analysis, and publication. A sequence of digital image processing techniques which have been demonstrated to effectively enhance such photographs is described.

  7. Historic Methods for Capturing Magnetic Field Images (United States)

    Kwan, Alistair


    I investigated two late 19th-century methods for capturing magnetic field images from iron filings for historical insight into the pedagogy of hands-on physics education methods, and to flesh out teaching and learning practicalities tacit in the historical record. Both methods offer opportunities for close sensory engagement in data-collection…

  8. Calibration of BVRI Photometry for the Wide Field Channel of the HST Advanced Camera for Surveys (United States)

    Saha, Abhijit; Shaw, Richard A.; Claver, Jennifer A.; Dolphin, Andrew E.


    We present new observations of two Galactic globular clusters, PAL4 and PAL14, using the Wide Field Channel of the Advanced Camera for Surveys (ACS) on board the Hubble Space Telescope (HST) and reanalyze archival data from a third, NGC2419. We matched our photometry of hundreds of stars in these fields from the ACS images to existing ground-based photometry of faint sequences that were calibrated on the standard BVRI system of Landolt. These stars are significantly fainter than those generally used for HST calibration purposes and therefore are much better matched to supporting precision photometry of ACS science targets. We were able to derive more accurate photometric transformation coefficients for the commonly used ACS broadband filters, compared with those published by Sirianni et al., due to the use of a factor of several more calibration stars that span a greater range of color. We find that the inferred transformations from each cluster individually do not vary significantly from the average, except for a small offset of the photometric zero point in the F850LP filter. Our results suggest that the published prescriptions for the time-dependent correction of CCD charge transfer efficiency appear to work very well over the ˜3.5 yr interval that spans our observations of PAL4 and PAL14 and the archived images of NGC2419.

  9. The ARGO-YBJ legacy to next generation wide field-of-view experiments

    Directory of Open Access Journals (Sweden)

    Di Sciascio Giuseppe


    Full Text Available The ARGO-YBJ experiment has been in stable data taking for more than 5 years at the YangBaJing Cosmic Ray Observatory (Tibet, P.R. China, 4300 m a.s.l., 606 g/cm2. With a duty-cycle greater than 86% the detector collected about 5×1011 events in a wide energy range, from few hundreds GeV up to about 10 PeV. High altitude location and detector features make ARGO-YBJ capable of investigating a wide range of important issues in Cosmic Ray and Astroparticle Physics by imaging the front of atmospheric showers with unprecedented resolution and detail. In this contribution some of the latest physics results obtained by ARGO-YBJ in gamma-ray astronomy and in cosmic ray physics are summarized. The prospects of TeV gamma-ray observations with new ground-based wide field-of-view detectors are presented.

  10. Airborne Wide Area Imager for Wildfire Mapping and Detection Project (United States)

    National Aeronautics and Space Administration — An advanced airborne imaging system for fire detection/mapping is proposed. The goal of the project is to improve control and management of wildfires in order to...

  11. Airborne Wide Area Imager for Wildfire Mapping and Detection Project (United States)

    National Aeronautics and Space Administration — An autonomous airborne imaging system for earth science research, disaster response, and fire detection is proposed. The primary goal is to improve information to...

  12. High throughput holographic imaging-in-flow for the analysis of a wide plankton size range. (United States)

    Yourassowsky, Catherine; Dubois, Frank


    We developed a Digital Holographic Microscope (DHM) working with a partial coherent source specifically adapted to perform high throughput recording of holograms of plankton organisms in-flow, in a size range of 3 µm-300 µm, which is of importance for this kind of applications. This wide size range is achieved with the same flow cell and with the same microscope magnification. The DHM configuration combines a high magnification with a large field of view and provides high-resolution intensity and quantitative phase images refocusing on high sample flow rate. Specific algorithms were developed to detect and extract automatically the particles and organisms present in the samples in order to build holograms of each one that are used for holographic refocusing and quantitative phase contrast imaging. Experimental results are shown and discussed.

  13. High Resolution Wide Field of View Stereographic Imaging System Project (United States)

    National Aeronautics and Space Administration — The overarching challenge of tele-presence is to provide an environment to the human operator that is sufficiently familiar that the interface itself does not become...

  14. "Molecular" MR imaging at high fields. (United States)

    Gore, John C; Zu, Zhongliang; Wang, Ping; Li, Hua; Xu, Junzhong; Dortch, Richard; Gochberg, Daniel F


    Magnetic resonance imaging (MRI) and spectroscopy (MRS) have contributed considerably to clinical radiology, and a variety of MR techniques have been developed to evaluate pathological processes as well as normal tissue biology at the cellular and molecular level. However, in comparison to nuclear imaging, MRI has relatively poor sensitivity for detecting true molecular changes or for detecting the presence of targeted contrast agents, though these remain under active development. In recent years very high field (7T and above) MRI systems have been developed for human studies and these provide new opportunities and technical challenges for molecular imaging. We identify 5 types of intrinsic contrast mechanisms that do not require the use of exogenous agents but which can provide molecular and cellular information. We can derive information on tissue composition by (i) imaging different nuclei, especially sodium (ii) exploiting chemical shift differences as in MRS (iii) exploiting specific relaxation mechanisms (iv) exploiting tissue differences in the exchange rates of molecular species such as amides or hydroxyls and (v) differences in susceptibility. The increased signal strength at higher fields enables higher resolution images to be acquired, along with increased sensitivity to detecting subtle effects caused by molecular changes in tissues. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Infrared light field imaging using single carbon nanotube detector (United States)

    Xi, Ning; Chen, Liangliang; Zhou, Zhanxin; Yang, Ruiguo; Song, Bo; Sun, Zhiyong


    The conventional photographs only record the sum total of light rays of each point on image plane so that they tell little about the amount of light traveling along individual rays. The focus and lens aberration problems have challenged photographers since the very beginning therefore light field photography was proposed to solve these problems. Lens array and multiple camera systems are used to capture 4D light rays, by reordering the different views of scene from multiple directions. The coded aperture is another method to encode the angular information in frequency domain. However, infrared light field sensing is still widely opening to research. In the paper, we will propose micro plane mirror optics together with compressive sensing algorithm to record light field in infrared spectrum. The micro mirror reflects objects irradiation and forms a virtual image behind the plane in which the mirror lies. The Digital Micromirror (DMD) consists of millions microscale mirrors which work as CCD array in the camera and it is controlled separately so as to project linear combination of object image onto lens. Coded aperture could be utilized to control angular resolution of infrared light rays. The carbon nanotube based infrared detector, which has ultra high signal to noise ratio and ultra fast responsibility, will sum up all image information on it without image distortion. Based on a number of measurements, compressive sensing algorithm was used to recover images from distinct angles, which could compute different views of scene to reconstruct infrared light field scence. Two innovative applications of full image recovery using nano scale photodetector and DMD based synthetic aperture photography will also be discussed in this paper.

  16. Optical Design of the WFIRST Phase-A Wide Field Instrument (United States)

    Pasquale, Bert A.; Marx, Catherine T.; Gao, Guangjun; Armani, Nerses; Casey, Thomas


    The WFIRST Wide-Field Infrared Survey Telescope TMA optical design provides 0.28-sq degrees FOV at 0.11” pixel scale to the Wide Field Instrument, operating between 0.48-2.0 micrometers, including a spectrograph mode (1.0-2.0 micrometers). An Integral Field Channel provides 2-D discrete spectroscopy at 0.15” & 0.3” sampling.

  17. Elliptical field-of-view PROPELLER imaging. (United States)

    Devaraj, Ajit; Pipe, James G


    Traditionally two-dimensional scans are designed to support an isotropic field-of-view (iFOV). When imaging elongated objects, significant savings in scan time can potentially be achieved by supporting an elliptical field-of-view (eFOV). This work presents an empirical closed-form solution to adapt the PROPELLER trajectory for an eFOV. The proposed solution is built on the geometry of the PROPELLER trajectory permitting the scan prescription and data reconstruction to remain largely similar to standard PROPELLER. The achieved FOV is experimentally validated by the point spread function (PSF) of a phantom scan. The details of potential savings in scan time and the signal-to-noise ratio (SNR) performance in comparison to iFOV scans for both phantom and in-vivo images are also described.

  18. A World Wide Web Region-Based Image Search Engine


    Kompatsiaris, Ioannis; Triantafyllou, Evangelia; Strintzis, Michael G.


    In this paper the development of an intelligent imagecontent-based search engine for the World Wide Web is presented.This system will offer a new form of media representationand access of content available in WWW. InformationWeb Crawlers continuously traverse the Internet and collectimages that are subsequently indexed based on integratedfeature vectors. As a basis for the indexing, the K-Meansalgorithm is used, modified so as to take into account thecoherence of the regions. Based on the ext...

  19. 76 FR 46854 - Hewlett Packard Company, Imaging and Printing Group, World Wide Product Data Management... (United States)


    ... Employment and Training Administration Hewlett Packard Company, Imaging and Printing Group, World Wide..., 2010, applicable to workers of Hewlett Packard Company, Imaging and Printing Group, World Wide Products..., now known as Experis, were employed on-site at the Boise, Idaho location of Hewlett Packard Company...

  20. Development of a Data Reduction algorithm for Optical Wide Field Patrol

    Directory of Open Access Journals (Sweden)

    Sun-youp Park


    Full Text Available The detector subsystem of the Optical Wide-field Patrol (OWL network efficiently acquires the position and time information of moving objects such as artificial satellites through its chopper system, which consists of 4 blades in front of the CCD camera. Using this system, it is possible to get more position data with the same exposure time by changing the streaks of the moving objects into many pieces with the fast rotating blades during sidereal tracking. At the same time, the time data from the rotating chopper can be acquired by the time tagger connected to the photo diode. To analyze the orbits of the targets detected in the image data of such a system, a sequential procedure of determining the positions of separated streak lines was developed that involved calculating the World Coordinate System (WCS solution to transform the positions into equatorial coordinate systems, and finally combining the time log records from the time tagger with the transformed position data. We introduce this procedure and the preliminary results of the application of this procedure to the test observation images.

  1. Three-dimensional radar imaging techniques and systems for near-field applications

    Energy Technology Data Exchange (ETDEWEB)

    Sheen, David M.; Hall, Thomas E.; McMakin, Douglas L.; Jones, Anthony M.; Tedeschi, Jonathan R.


    The Pacific Northwest National Laboratory has developed three-dimensional holographic (synthetic aperture) radar imaging techniques and systems for a wide variety of near-field applications. These applications include radar cross-section (RCS) imaging, personnel screening, standoff concealed weapon detection, concealed threat detection, through-barrier imaging, ground penetrating radar (GPR), and non-destructive evaluation (NDE). Sequentially-switched linear arrays are used for many of these systems to enable high-speed data acquisition and 3-D imaging. In this paper, the techniques and systems will be described along with imaging results that demonstrate the utility of near-field 3-D radar imaging for these compelling applications.

  2. Advances on Hubble Wide Field Camera 3 Grism Calibration and Slitless Spectroscopy Analysis (United States)

    Fowler, Julia; Brammer, Gabriel; Ryan, Russell; Deustua, Susana; Pirzkal, Nor


    Grisms are spectral elements combining a grating and prism to conduct slitless spectroscopy; presently they make up approximately 13% of all Wide Field Camera 3 (WFC3) observations on the Hubble Space Telescope (HST). WFC3 contains three grisms, two for the infrared (IR) channel and one for the ultraviolet-visible (UVIS). Here we summarize recent results from an ongoing effort to improve the analysis tools, characterization, and calibration of WFC3 slitless spectroscopic observations. This includes (1) calibrating the IR wavelength solutions with respect to compact zeroth order images, (2) improved IR throughput curves from modelling grism flux by extending the pixel range of effective point spread functions, (3) IR linear-reconstruction solving methods that solve for optimal, non-parametric spectra, (4) calibrating the UVIS +1 and -1 order over the entire field of view of both chips (allowing for spectral extraction from the entire UVIS detector.) With these efforts we continue to improve and advance the science possible with WFC3 grism observations.

  3. Integration of digital gross pathology images for enterprise-wide access

    Directory of Open Access Journals (Sweden)

    Milon Amin


    Full Text Available Background: Sharing digital pathology images for enterprise- wide use into a picture archiving and communication system (PACS is not yet widely adopted. We share our solution and 3-year experience of transmitting such images to an enterprise image server (EIS. Methods: Gross pathology images acquired by prosectors were integrated with clinical cases into the laboratory information system′s image management module, and stored in JPEG2000 format on a networked image server. Automated daily searches for cases with gross images were used to compile an ASCII text file that was forwarded to a separate institutional Enterprise Digital Imaging and Communications in Medicine (DICOM Wrapper (EDW server. Concurrently, an HL7-based image order for these cases was generated, containing the locations of images and patient data, and forwarded to the EDW, which combined data in these locations to generate images with patient data, as required by DICOM standards. The image and data were then "wrapped" according to DICOM standards, transferred to the PACS servers, and made accessible on an institution-wide basis. Results: In total, 26,966 gross images from 9,733 cases were transmitted over the 3-year period from the laboratory information system to the EIS. The average process time for cases with successful automatic uploads (n=9,688 to the EIS was 98 seconds. Only 45 cases (0.5% failed requiring manual intervention. Uploaded images were immediately available to institution- wide PACS users. Since inception, user feedback has been positive. Conclusions: Enterprise- wide PACS- based sharing of pathology images is feasible, provides useful services to clinical staff, and utilizes existing information system and telecommunications infrastructure. PACS-shared pathology images, however, require a "DICOM wrapper" for multisystem compatibility.

  4. Gravimetric monitoring of the first field-wide steam injection in a fractured carbonate field in Oman - A feasibility study

    NARCIS (Netherlands)

    Glegola, M.; Ditmar, P.; Vossepoel, F.; Arts, R.; Al-Kindy, F.; Klees, R.


    Gas-Oil Gravity Drainage is to be enhanced by steam injection in a highly fractured, low permeability carbonate field in Oman. Following a successful pilot, field-wide steam injection is being implemented, first of this type in the world. A dedicated monitoring program has been designed to track

  5. ISS-Lobster: A Proposed Wide-Field X-Ray Telescope on the International Space Station (United States)

    Camp, Jordan


    The Lobster wide-field imaging telescope combines simultaneous high FOV, high sensitivity and good position resolution. These characteristics can open the field of X-Ray time domain astronomy, which will study many interesting transient sources, including tidal disruptions of stars, supernova shock breakouts, and high redshift gamma-ray bursts. Also important will be its use for the X-ray follow-up of gravitational wave detections. I will describe our present effort to propose the Lobster concept for deployment on the International Space Station through a NASA Mission of Opportunity this fall.

  6. Wide-field monitoring strategy for the study of fast optical transients (United States)

    Beskin, Grigory; Bondar, Sergey; Karpov, Sergey; Guarnieri, Adriano; Bartolini, Corrado; Greco, Giuseppe; Piccioni, Adalberto


    We discuss the strategy of search for fast optical transients accompanying gamma-ray bursts by means of continuous monitoring of wide sky fields with high temporal resolution. We describe the design, performance and results of our cameras, FAVOR and TORTORA. Also we discuss the perspectives of this strategy and possible design of next-generation equipment for wide-field monitoring which will be able to detect optical transients and to study their color and polarization properties with high time resolution.

  7. Image Filtering with Field Programmable Gate Array

    Directory of Open Access Journals (Sweden)

    Arūnas Šlenderis


    Full Text Available The research examined the use of field programmable gate arrays (FPGA in image filtering. Experimental and theoretical researches were reviewed. Experiments with Cyclone III family FPGA chip with implemented NIOS II soft processor were considered. Image filtering was achieved with symmetrical and asymmetrical finite impulse response filters with convolution kernel. The system, which was implemented with 3×3 symmetrical filter, which was implemented using the hardware description language, uses 59% of logic elements of the chip and 10 multiplication elements. The system with asymmetrical filter uses the same amount of logic elements and 13 multiplication elements. Both filter systems consume approx. 545 mW of power. The system, which is designed for filter implementation in C language, uses 65% of all logical elements and consumes 729 mW of power.Article in Lithuanian

  8. A low-noise wide dynamic range CMOS image sensor with low and high temperatures resistance (United States)

    Mizobuchi, Koichi; Adachi, Satoru; Tejada, Jose; Oshikubo, Hiromichi; Akahane, Nana; Sugawa, Shigetoshi


    A temperature-resistant 1/3 inch SVGA (800×600 pixels) 5.6 μm pixel pitch wide-dynamic-range (WDR) CMOS image sensor has been developed using a lateral-over-flow-integration-capacitor (LOFIC) in a pixel. The sensor chips are fabricated through 0.18 μm 2P3M process with totally optimized front-end-of-line (FEOL) & back-end-of-line (BEOL) for a lower dark current. By implementing a low electrical field potential design for photodiodes, reducing damages, recovering crystal defects and terminating interface states in the FEOL+BEOL, the dark current is improved to 12 e - /pixel-sec at 60 deg.C with 50% reduction from the previous very-low-dark-current (VLDC) FEOL and its contribution to the temporal noise is improved. Furthermore, design optimizations of the readout circuits, especially a signal-and noise-hold circuit and a programmable-gain-amplifier (PGA) are also implemented. The measured temporal noise is 2.4 e -rms at 60 fps (:36 MHz operation). The dynamic-range (DR) is extended to 100 dB with 237 ke - full well capacity. In order to secure the temperature-resistance, the sensor chip also receives both an inorganic cap onto micro lens and a metal hermetic seal package assembly. Image samples at low & high temperatures show significant improvement in image qualities.

  9. A Multispectral Micro-Imager for Lunar Field Geology (United States)

    Nunez, Jorge; Farmer, Jack; Sellar, Glenn; Allen, Carlton


    Field geologists routinely assign rocks to one of three basic petrogenetic categories (igneous, sedimentary or metamorphic) based on microtextural and mineralogical information acquired with a simple magnifying lens. Indeed, such observations often comprise the core of interpretations of geological processes and history. The Multispectral Microscopic Imager (MMI) uses multi-wavelength, light-emitting diodes (LEDs) and a substrate-removed InGaAs focal-plane array to create multispectral, microscale reflectance images of geological samples (FOV 32 X 40 mm). Each pixel (62.5 microns) of an image is comprised of 21 spectral bands that extend from 470 to 1750 nm, enabling the discrimination of a wide variety of rock-forming minerals, especially Fe-bearing phases. MMI images provide crucial context information for in situ robotic analyses using other onboard analytical instruments (e.g. XRD), or for the selection of return samples for analysis in terrestrial labs. To further assess the value of the MMI as a tool for lunar exploration, we used a field-portable, tripod-mounted version of the MMI to image a variety of Apollo samples housed at the Lunar Experiment Laboratory, NASA s Johnson Space Center. MMI images faithfully resolved the microtextural features of samples, while the application of ENVI-based spectral end member mapping methods revealed the distribution of Fe-bearing mineral phases (olivine, pyroxene and magnetite), along with plagioclase feldspars within samples. Samples included a broad range of lithologies and grain sizes. Our MMI-based petrogenetic interpretations compared favorably with thin section-based descriptions published in the Lunar Sample Compendium, revealing the value of MMI images for astronaut and rover-mediated lunar exploration.


    Energy Technology Data Exchange (ETDEWEB)

    Strader, Jay [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Romanowsky, Aaron J.; Brodie, Jean P.; Beasley, Michael A.; Arnold, Jacob A. [UCO/Lick Observatory, University of California, Santa Cruz, CA 95064 (United States); Spitler, Lee R. [Center for Astrophysics and Supercomputing, Swinburne University, Hawthorn, VIC 3122 (Australia); Tamura, Naoyuki [Subaru Telescope, National Astronomical Observatory of Japan, Hilo, HI 96720 (United States); Sharples, Ray M. [Department of Physics, University of Durham, South Road, Durham (United Kingdom); Arimoto, Nobuo, E-mail: [National Astronomical Observatory of Japan, Mitaka, Tokyo 181-8588 (Japan)


    We present the most extensive combined photometric and spectroscopic study to date of the enormous globular cluster (GC) system around M87, the central giant elliptical galaxy in the nearby Virgo Cluster. Using observations from DEIMOS and the Low Resolution Imaging Spectrometer at Keck, and Hectospec on the Multiple Mirror Telescope, we derive new, precise radial velocities for 451 GCs around M87, with projected radii from {approx}5 to 185 kpc. We combine these measurements with literature data for a total sample of 737 objects, which we use for a re-examination of the kinematics of the GC system of M87. The velocities are analyzed in the context of archival wide-field photometry and a novel Hubble Space Telescope catalog of half-light radii, which includes sizes for 344 spectroscopically confirmed clusters. We use this unique catalog to identify 18 new candidate ultracompact dwarfs and to help clarify the relationship between these objects and true GCs. We find much lower values for the outer velocity dispersion and rotation of the GC system than in earlier papers and also differ from previous work in seeing no evidence for a transition in the inner halo to a potential dominated by the Virgo Cluster, nor for a truncation of the stellar halo. We find little kinematical evidence for an intergalactic GC population. Aided by the precision of the new velocity measurements, we see significant evidence for kinematical substructure over a wide range of radii, indicating that M87 is in active assembly. A simple, scale-free analysis finds less dark matter within {approx}85 kpc than in other recent work, reducing the tension between X-ray and optical results. In general, out to a projected radius of {approx}150 kpc, our data are consistent with the notion that M87 is not dynamically coupled to the Virgo Cluster; the core of Virgo may be in the earliest stages of assembly.

  11. Hospital-wide PACS with a digital image intensifier TV system. (United States)

    Okaniwa, H; Tsuneyoshi, H; Kabata, S; Satoh, K; Yokouchi, H; Okabe, T


    Tokyo Hitachi Hospital, Hitachi Ltd., has used a hospital-wide PACS for over 1 year. The system runs a 100 Mb/s optical fiber network over the whole hospital including wards and outpatient clinic rooms, with 11 image workstations. The network links digital imaging modalities such as X-CT, MRI, computed radiography (CR) and digital radiography (DR) with a 2048 x 2048 (2k x 2k) matrix image intensifier television (I.I.-TV) system. These modalities generate about 200 images/day. The system has managed over 300,000 images of about 8000 patients so far. Although being still under improvement, the system has really been used for routine work. The hospital-wide PACS of a small hospital has been proved to be very useful for both image diagnosis and image management.


    Energy Technology Data Exchange (ETDEWEB)

    Koenig, X. P.; Leisawitz, D. T.; Benford, D. J.; Padgett, D. L. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Rebull, L. M. [Spitzer Science Center (SSC), California Institute of Technology, M/S 220-6, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Assef, R. J. [Jet Propulsion Laboratory, MS 169-530, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States)


    We present the results of a mid-infrared survey of 11 outer Galaxy massive star-forming regions and 3 open clusters with data from the Wide-field Infrared Survey Explorer (WISE). Using a newly developed photometric scheme to identify young stellar objects and exclude extragalactic contamination, we have studied the distribution of young stars within each region. These data tend to support the hypothesis that latter generations may be triggered by the interaction of winds and radiation from the first burst of massive star formation with the molecular cloud material leftover from that earlier generation of stars. We dub this process the 'fireworks hypothesis' since star formation by this mechanism would proceed rapidly and resemble a burst of fireworks. We have also analyzed small cutout WISE images of the structures around the edges of these massive star-forming regions. We observe large (1-3 pc size) pillar and trunk-like structures of diffuse emission nebulosity tracing excited polycyclic aromatic hydrocarbon molecules and small dust grains at the perimeter of the massive star-forming regions. These structures contain small clusters of emerging Class I and Class II sources, but some are forming only a single to a few new stars.

  13. Wide-Field Infrared Survey Explorer Observations of the Evolution of Massive Star-Forming Regions (United States)

    Koenig, X. P.; Leisawitz, D. T.; Benford, D. J.; Rebull, L. M.; Padgett, D. L.; Asslef, R. J.


    We present the results of a mid-infrared survey of II outer Galaxy massive star-forming regions and 3 open clusters with data from the Wide-field Infrared Survey Explorer (WISE). Using a newly developed photometric scheme to identify young stellar objects and exclude extragalactic contamination, we have studied the distribution of young stars within each region. These data tend to support the hypothesis that latter generations may be triggered by the interaction of winds and radiation from the first burst of massive star formation with the molecular cloud material leftover from that earlier generation of stars. We dub this process the "fireworks hypothesis" since star formation by this mechanism would proceed rapidly and resemble a burst of fireworks. We have also analyzed small cutout WISE images of the structures around the edges of these massive star-forming regions. We observe large (1-3 pc size) pillar and trunk-like structures of diffuse emission nebulosity tracing excited polycyclic aromatic hydrocarbon molecules and small dust grains at the perimeter of the massive star-forming regions. These structures contain small clusters of emerging Class I and Class II sources, but some are forming only a single to a few new stars.

  14. A Compact, Wide Area Surveillance 3D Imaging LIDAR Providing UAS Sense and Avoid Capabilities Project (United States)

    National Aeronautics and Space Administration — Eye safe 3D Imaging LIDARS when combined with advanced very high sensitivity, large format receivers can provide a robust wide area search capability in a very...

  15. VizieR Online Data Catalog: Wide-field spectrosc. survey of GCs in Virgo cluster (Ko+, 2017) (United States)

    Ko, Y.; Hwang, H. S.; Lee, M. G.; Park, H. S.; Lim, S.; Sohn, J.; Jang, I. S.; Hwang, N.; Park, B.-G.


    We selected globular cluster (GC) candidates using the Next Generation Virgo Cluster Survey (NGVS; Ferrarese+ 2012ApJS..200....4F) archival images covering the central region of the Virgo cluster. The NGVS is a wide-field imaging survey of the Virgo cluster using MegaCam with a field of view of 1°x1° attached at the Canada-French-Hawaii Telescope. We carried out spectroscopic observation of GC candidates in the Virgo using the Hectospec mounted on the 6.5m Multiple-Mirror Telescope in queue mode under program ID 2014A-UAO-G18 (PI: Myung Gyoon Lee) between 2014 February and March (wavelength range: 3650Å to 9200Å). (3 data files).

  16. Wide-field time-correlated single photon counting (TCSPC) microscopy with time resolution below the frame exposure time

    Energy Technology Data Exchange (ETDEWEB)

    Hirvonen, Liisa M. [Department of Physics, King' s College London, Strand, London WC2R 2LS (United Kingdom); Petrášek, Zdeněk [Max Planck Institute of Biochemistry, Department of Cellular and Molecular Biophysics, Am Klopferspitz 18, D-82152 Martinsried (Germany); Suhling, Klaus, E-mail: [Department of Physics, King' s College London, Strand, London WC2R 2LS (United Kingdom)


    Fast frame rate CMOS cameras in combination with photon counting intensifiers can be used for fluorescence imaging with single photon sensitivity at kHz frame rates. We show here how the phosphor decay of the image intensifier can be exploited for accurate timing of photon arrival well below the camera exposure time. This is achieved by taking ratios of the intensity of the photon events in two subsequent frames, and effectively allows wide-field TCSPC. This technique was used for measuring decays of ruthenium compound Ru(dpp) with lifetimes as low as 1 μs with 18.5 μs frame exposure time, including in living HeLa cells, using around 0.1 μW excitation power. We speculate that by using an image intensifier with a faster phosphor decay to match a higher camera frame rate, photon arrival time measurements on the nanosecond time scale could well be possible.

  17. Biocytin wide-field bipolar cells in rabbit retina selectively contact blue cones. (United States)

    MacNeil, Margaret A; Gaul, Paulette A


    The biocytin wide-field bipolar cell in rabbit retina has a broad axonal arbor in layer 5 of the inner plexiform layer and a wide dendritic arbor that does not contact all cones in its dendritic field. The purpose of our study was to identify the types of cones that this cell contacts. We identified the bipolar cells by selective uptake of biocytin, labeled the cones with peanut agglutinin, and then used antibodies against blue cone opsin and red-green cone opsin to identify the individual cone types. The biocytin-labeled cells selectively contacted cones whose outer segments stained for blue cone opsin and avoided cones that did not. We conclude that the biocytin wide-field bipolar cell is an ON blue cone bipolar cell in the rabbit retina and is homologous to the blue cone bipolar cells that have been previously described in primate, mouse, and ground squirrel retinas. Copyright 2007 Wiley-Liss, Inc.

  18. Retinal pigment epithelium findings in patients with albinism using wide-field polarization-sensitive optical coherence tomography. (United States)

    Schütze, Christopher; Ritter, Markus; Blum, Robert; Zotter, Stefan; Baumann, Bernhard; Pircher, Michael; Hitzenberger, Christoph K; Schmidt-Erfurth, Ursula


    To investigate pigmentation characteristics of the retinal pigment epithelium (RPE) in patients with albinism using wide-field polarization-sensitive optical coherence tomography compared with intensity-based spectral domain optical coherence tomography and fundus autofluorescence imaging. Five patients (10 eyes) with previously genetically diagnosed albinism and 5 healthy control subjects (10 eyes) were imaged by a wide-field polarization-sensitive optical coherence tomography system (scan angle: 40 × 40° on the retina), sensitive to melanin contained in the RPE, based on the polarization state of backscattered light. Conventional intensity-based spectral domain optical coherence tomography and fundus autofluorescence examinations were performed. Retinal pigment epithelium-pigmentation was analyzed qualitatively and quantitatively based on depolarization assessed by polarization-sensitive optical coherence tomography. This study revealed strong evidence of polarization-sensitive optical coherence tomography to specifically image melanin in the RPE. Depolarization of light backscattered by the RPE in patients with albinism was reduced compared with normal subjects. Heterogeneous RPE-specific depolarization characteristics were observed in patients with albinism. Reduction of depolarization observed in the light backscattered by the RPE in patients with albinism corresponds to expected decrease of RPE pigmentation. The degree of depigmentation of the RPE is possibly associated with visual acuity. Findings suggest that different albinism genotypes result in heterogeneous levels of RPE pigmentation. Polarization-sensitive optical coherence tomography showed a heterogeneous appearance of RPE pigmentation in patients with albinism depending on different genotypes.

  19. Dosimetric impact of image artifact from a wide-bore CT scanner in radiotherapy treatment planning

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Vincent; Podgorsak, Matthew B.; Tran, Tuan-Anh; Malhotra, Harish K.; Wang, Iris Z. [Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263 (United States); Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263 and Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214 (United States); Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263 (United States); Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263 and Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214 (United States)


    Purpose: Traditional computed tomography (CT) units provide a maximum scan field-of-view (sFOV) diameter of 50 cm and a limited bore size, which cannot accommodate a large patient habitus or an extended simulation setup in radiation therapy (RT). Wide-bore CT scanners with increased bore size were developed to address these needs. Some scanners have the capacity to reconstruct the CT images at an extended FOV (eFOV), through data interpolation or extrapolation, using projection data acquired with a conventional sFOV. Objects that extend past the sFOV for eFOV reconstruction may generate image artifacts resulting from truncated projection data; this may distort CT numbers and structure contours in the region beyond the sFOV. The purpose of this study was to evaluate the dosimetric impact of image artifacts from eFOV reconstruction with a wide-bore CT scanner in radiotherapy (RT) treatment planning. Methods: Testing phantoms (i.e., a mini CT phantom with equivalent tissue inserts, a set of CT normal phantoms and anthropomorphic phantoms of the thorax and the pelvis) were used to evaluate eFOV artifacts. Reference baseline images of these phantoms were acquired with the phantom centrally positioned within the sFOV. For comparison, the phantoms were then shifted laterally and scanned partially outside the sFOV, but still within the eFOV. Treatment plans were generated for the thoracic and pelvic anthropomorphic phantoms utilizing the Eclipse treatment planning system (TPS) to study the potential effects of eFOV artifacts on dose calculations. All dose calculations of baseline and test treatment plans were carried out using the same MU. Results: Results show that both body contour and CT numbers are altered by image artifacts in eFOV reconstruction. CT number distortions of up to -356 HU for bone tissue and up to 323 HU for lung tissue were observed in the mini CT phantom. Results from the large body normal phantom, which is close to a clinical patient size, show

  20. Hubble Space Telescope Wide Field Planetary Camera 2 Observations of Neptune (United States)


    Two groups have recently used the Hubble Space Telescope (HST) Wide Field Planetary Camera 2 (WFPC 2) to acquire new high-resolution images of the planet Neptune. Members of the WFPC-2 Science Team, lead by John Trauger, acquired the first series of images on 27 through 29 June 1994. These were the highest resolution images of Neptune taken since the Voyager-2 flyby in August of 1989. A more comprehensive program is currently being conducted by Heidi Hammel and Wes Lockwood. These two sets of observations are providing a wealth of new information about the structure, composition, and meteorology of this distant planet's atmosphere.Neptune is currently the most distant planet from the sun, with an orbital radius of 4.5 billion kilometers (2.8 billion miles, or 30 Astronomical Units). Even though its diameter is about four times that of the Earth (49,420 vs. 12,742 km), ground-based telescopes reveal a tiny blue disk that subtends less than 1/1200 of a degree (2.3 arc-seconds). Neptune has therefore been a particularly challenging object to study from the ground because its disk is badly blurred by the Earth's atmosphere. In spite of this, ground-based astronomers had learned a great deal about this planet since its position was first predicted by John C. Adams and Urbain Leverrier in 1845. For example, they had determined that Neptune was composed primarily of hydrogen and helium gas, and that its blue color caused by the presence of trace amounts of the gas methane, which absorbs red light. They had also detected bright cloud features whose brightness changed with time, and tracked these clouds to infer a rotation period between 17 and 22 hours.When the Voyager-2 spacecraft flew past the Neptune in 1989, its instruments revealed a surprising array of meteorological phenomena, including strong winds, bright, high-altitude clouds, and two large dark spots attributed to long-lived giant storm systems. These bright clouds and dark spots were tracked as they moved

  1. SQUID-Detected Magnetic Resonance Imaging in MicroteslaFields

    Energy Technology Data Exchange (ETDEWEB)

    Moessle, Michael; Hatridge, Michael; Clarke, John


    Magnetic resonance imaging (MRI) has developed into a powerful clinical tool for imaging the human body (1). This technique is based on nuclear magnetic resonance (NMR) of protons (2, 3) in a static magnetic field B{sub 0}. An applied radiofrequency pulse causes the protons to precess about B{sub 0} at their Larmor frequency {nu}{sub 0} = ({gamma}/2{pi})B{sub 0}, where {gamma} is the gyromagnetic ratio; {gamma}/2{pi} = 42.58 MHz/tesla. The precessing protons generate an oscillating magnetic field and hence a voltage in a nearby coil that is amplified and recorded. The application of three-dimensional magnetic field gradients specifies a unique magnetic field and thus an NMR frequency in each voxel of the subject, so that with appropriate encoding of the signals one can acquire a complete image (4). Most clinical MRI systems involve magnetic fields generated by superconducting magnets, and the current trend is to higher magnetic fields than the widely used 1.5-T systems (5). Nonetheless, there is ongoing interest in the development of less expensive imagers operating at lower fields. Commercially available 0.2-T systems based on permanent magnets offer both lower cost and a more open access than their higher-field counterparts, at the expense of signal-to-noise-ratio (SNR) and spatial resolution. At the still lower field of 0.03 mT maintained by a conventional, room-temperature solenoid, Connolly and co-workers (6, 7) obtain good spatial resolution and signal-to-noise ratio (SNR) by prepolarizing the protons in a field B{sub p} of 0.3 T. Prepolarization (8) enhances the magnetic moment of an ensemble of protons over that produced by the lower precession field; after the polarizing field is removed, the higher magnetic moment produces a correspondingly larger signal during its precession in B{sub 0}. Using the same method, Stepisnik et al. (9) obtained MR images in the Earth's magnetic field ({approx} 50 {micro}T). Alternatively, one can enhance the signal

  2. A wide-field TCSPC FLIM system based on an MCP PMT with a delay-line anode


    Becker, Wolfgang; Hirvonen, Liisa; Milnes, James; Conneely, Thomas; Jagutzki, Ottmar; Netz, Holger; Smietana, Stefan; Suhling, Klaus


    We report on the implementation of a wide-field time-correlated single photon counting (TCSPC) method for fluorescence lifetime imaging (FLIM). It is based on a 40 mm diameter crossed delay line anode detector, where the readout is performed by three standard TCSPC boards. Excitation is performed by a picosecond diode laser with 50 MHz repetition rate. The photon arrival timing is obtained directly from the microchannel plates, with an instrumental response of ∼190 to 230 ps full width at hal...

  3. Wide-field human photoreceptor morphological analysis using phase-resolved sensorless adaptive optics swept-source OCT (Conference Presentation) (United States)

    Ju, Myeong Jin; Heisler, Morgan; Zawadzki, Robert J.; Bonora, Stefano; Jian, Yifan; Sarunic, Marinko V.


    Adaptive optics optical coherence tomography (AO-OCT) systems capable of 3D high resolution imaging have been applied to posterior eye imaging in order to resolve the fine morphological features in the retina. Human cone photoreceptors have been extensively imaged and studied for the investigation of retinal degeneration resulting in photoreceptor cell death. However, there are still limitations of conventional approaches to AO in the clinic, such as relatively small field-of-view (FOV) and the complexities in system design and operation. In this research, a recently developed phase-resolved Sensorless AO Swept Source based OCT (SAO-SS-OCT) system which is compact in size and easy to operate is presented. Owing to its lens-based system design, wide-field imaging can be performed up to 6° on the retina. A phase stabilization unit was integrated with the OCT system. With the phase stabilized OCT signal, we constructed retinal micro-vasculature image using a phase variance technique. The retinal vasculature image was used to align and average multiple OCT volumes acquired sequentially. The contrast-enhanced photoreceptor projection image was then extracted from the averaged volume, and analyzed based on its morphological features through a novel photoreceptor structure evaluation algorithm. The retinas of twelve human research subjects (10 normal and 2 pathological cases) were measured in vivo. Quantitative parameters used for evaluating the cone photoreceptor mosaic such as cell density, cell area, and mosaic regularity are presented and discussed. The SAO-SS-OCT system and the proposed photoreceptor evaluation method has significant potential to reveal early stage retinal diseases associated with retinal degeneration.

  4. Performance Improvement of Near Earth Space Survey (NESS Wide-Field Telescope (NESS-2 Optics

    Directory of Open Access Journals (Sweden)

    Sung-Yeol Yu


    Full Text Available We modified the optical system of 500 mm wide-field telescope of which point spread function showed an irregularity. The telescope has been operated for Near Earth Space Survey (NESS located at Siding Spring Observatory (SSO in Australia, and the optical system was brought back to Korea in January 2008. After performing a numerical simulation with the tested value of surface figure error of the primary mirror using optical design program, we found that the surface figure error of the mirror should be fabricated less than root mean square (RMS λ/10 in order to obtain a stellar full width at half maximum (FWHM below 28 μm. However, we started to figure the mirror for the target value of RMS λ/20, because system surface figure error would be increased by the error induced by the optical axis adjustment, mirror cell installation, and others. The radius of curvature of the primary mirror was 1,946 mm after the correction. Its measured surface figure error was less than RMS λ/20 on the table of polishing machine, and RMS λ/15 after installation in the primary mirror cell. A test observation performed at Daeduk Observatory at Korea Astronomy and Space Science Institute by utilizing the exiting mount, and resulted in 39.8 μm of stellar FWHM. It was larger than the value from numerical simulation, and showed wing-shaped stellar image. It turned out that the measured-curvature of the secondary mirror, 1,820 mm, was not the same as the designed one, 1,795.977 mm. We fabricated the secondary mirror to the designed value, and finally obtained a stellar FWHM of 27 μm after re-installation of the optical system into SSO NESS Observatory in Australia.

  5. SixPak: a wide-field IFU for the William Herschel Telescope

    NARCIS (Netherlands)

    Venema, Lars B.; Schoenmaker, Ton; Verheijen, Marc; Trager, Scott; Rutten, René; Bershady, Matthew; Larsen, Søren; Peletier, Reynier; Spaans, Marco


    We intend to construct SixPak, a wide-field fibre-based IFU for the 4.2-meter William Herschel Telescope on La Palma. The fibre bundle will consist of 238 fibres, each 3.0 arcsec in diameter, piping light from the Nasmyth focal plane of the WHT to the existing WYFFOS bench spectrograph. A total of

  6. Infrared Testing of the Wide-field Infrared Survey Telescope Grism Using Computer Generated Holograms (United States)

    Dominguez, Margaret Z.; Content, David A.; Gong, Qian; Griesmann, Ulf; Hagopian, John G.; Marx, Catherine T; Whipple, Arthur L.


    Infrared Computer Generated Holograms (CGHs) were designed, manufactured and used to measure the performance of the grism (grating prism) prototype which includes testing Diffractive Optical Elements (DOE). The grism in the Wide Field Infrared Survey Telescope (WFIRST) will allow the surveying of a large section of the sky to find bright galaxies.

  7. Investigation of ground target detection methods in fully polarimetric wide angle synthetic aperture radar images (United States)

    Laggan, Wayne B.


    Target detection is a high priority of the Air Force for the purpose of reconnaissance and bombardment. This research investigates and develops methods to distinguish ground targets from clutter (i.e. foliage, landscape etc.) in Wide Angle Synthetic Aperture Radar (WASAR) images. WASAR uses multiple aspect angle SAR images of the same target scene. The WASAR data was generated from a pre-release software package (XPATCH-ES) provided by the sponsor (WL-AARA). A statistical analysis and feature extraction is performed on the XPATCH-ES data. Polarimetric and wide angle covariance matrices are estimated and analyzed. From an analysis of the wide angle covariance matrix it is shown that natural clutter has in general a uniform radar return for changing aspect angles, whereas the radar return for a target varies. Based on this analysis, two new wide angle algorithms, the WASAR Whitening Filter and the Adaptive WASAR Whitening Filter (AWWF) are developed. The target detection performance of polarimetric and multi aspect angle image combining algorithms are quantified using Receiver Operating Characteristic curves and target to clutter ratios. It is shown that wide angle processing provides superior target detection performance over polarimetric processing. Combinations of wide angle and polarimetric algorithms were used to achieve a 13.7 dB processing gain in target to clutter ratio when compared to unprocessed images of the target scene. This represents a significant improvement in target detection capabilities.

  8. Wide field monitoring of the X-ray sky using Rotation Modulation Collimators

    DEFF Research Database (Denmark)

    Lund, Niels; Brandt, Søren


    Wide field monitoring is of particular interest in X-ray astronomy due to the strong time-variability of most X-ray sources. Not only does the time-profiles of the persistent sources contain characteristic signatures of the underlying physical systems, but, additionally, some of the most intriguing...... sources have long periods of quiesense in which they are almost undetectable as X-ray sources, interspersed with relatively brief periods of intense outbursts, where we have unique opportunities of studying dynamical effects, in, for instance, the evolution of accretion discs. Another question for which...... wide field monitors may provide key information, is the origin and nature of the cosmic gamma ray bursts.Rotation Modulation Collimators (RMC's) were originally introduced in X-ray astronomy to provide accurate source localizations over extended fields. This role has since been taken over...

  9. The biocytin wide-field bipolar cell in the rabbit retina selectively contacts blue cones (United States)

    MacNeil, Margaret A.; Gaul, Paulette A.


    The biocytin wide-field bipolar cell in rabbit retina is a sparsely populated ON cone bipolar cell with a broad dendritic arbor that does not contact all cones in its dendritic field. The purpose of our study was to identify the cone types that this cell contacts. We identified the bipolar cells by selective uptake of biocytin, labeled the cones with peanut agglutinin and then used antibodies against blue cone opsin and red-green cone opsin to identify the individual cone types. The biocytin-labeled cells selectively contacted cones whose outer segments stained for blue cone opsin and avoided cones that did not. We conclude that the biocytin wide-field bipolar cell is an ON blue cone bipolar cell in the rabbit retina and is homologous to the blue cone bipolar cells that have been previously described in primate, mouse, and ground squirrel retinas. PMID:17990268

  10. Near-Field Cross Section Imaging of Wideband Millimeter Wave

    Directory of Open Access Journals (Sweden)

    Kan Yingzhi


    Full Text Available Near-field millimeter wave imaging has been a hot topic recent years for its importance applications in the area of anti-terrorism. The penetrating characteristic of millimeter wave is of significant importance to security, such as the concealed weapons detection, ground-penetrating radar imaging, through-barrier imaging and so on. Cross section imaging is a basic aspect for near-field millimeter wave imaging, which includes antenna array distribution and wideband signal processing. This paper utilizes back projection method in space area to realize ultra-band nearfield cross section imaging. We induce two dimensional direction integral formulas to obtain the reconstruction image of the near-field imaging area, and the simulation results validate the effectiveness of this imaging algorithm.

  11. Short-channel field-effect transistors with 9-atom and 13-atom wide graphene nanoribbons. (United States)

    Llinas, Juan Pablo; Fairbrother, Andrew; Borin Barin, Gabriela; Shi, Wu; Lee, Kyunghoon; Wu, Shuang; Yong Choi, Byung; Braganza, Rohit; Lear, Jordan; Kau, Nicholas; Choi, Wonwoo; Chen, Chen; Pedramrazi, Zahra; Dumslaff, Tim; Narita, Akimitsu; Feng, Xinliang; Müllen, Klaus; Fischer, Felix; Zettl, Alex; Ruffieux, Pascal; Yablonovitch, Eli; Crommie, Michael; Fasel, Roman; Bokor, Jeffrey


    Bottom-up synthesized graphene nanoribbons and graphene nanoribbon heterostructures have promising electronic properties for high-performance field-effect transistors and ultra-low power devices such as tunneling field-effect transistors. However, the short length and wide band gap of these graphene nanoribbons have prevented the fabrication of devices with the desired performance and switching behavior. Here, by fabricating short channel (L ch ~ 20 nm) devices with a thin, high-κ gate dielectric and a 9-atom wide (0.95 nm) armchair graphene nanoribbon as the channel material, we demonstrate field-effect transistors with high on-current (I on > 1 μA at V d = -1 V) and high I on /I off ~ 10(5) at room temperature. We find that the performance of these devices is limited by tunneling through the Schottky barrier at the contacts and we observe an increase in the transparency of the barrier by increasing the gate field near the contacts. Our results thus demonstrate successful fabrication of high-performance short-channel field-effect transistors with bottom-up synthesized armchair graphene nanoribbons.Graphene nanoribbons show promise for high-performance field-effect transistors, however they often suffer from short lengths and wide band gaps. Here, the authors use a bottom-up synthesis approach to fabricate 9- and 13-atom wide ribbons, enabling short-channel transistors with 10(5) on-off current ratio.

  12. Concerning the Development of the Wide-Field Optics for WFXT Including Methods of Optimizing X-Ray Optical Prescriptions for Wide-Field Applications (United States)

    Weisskopf, M. C.; Elsner, R. F.; O'Dell, S. L.; Ramsey, B. D.


    We present a progress report on the various endeavors we are undertaking at MSFC in support of the Wide Field X-Ray Telescope development. In particular we discuss assembly and alignment techniques, in-situ polishing corrections, and the results of our efforts to optimize mirror prescriptions including polynomial coefficients, relative shell displacements, detector placements and tilts. This optimization does not require a blind search through the multi-dimensional parameter space. Under the assumption that the parameters are small enough so that second order expansions are valid, we show that the performance at the detector can be expressed as a quadratic function with numerical coefficients derived from a ray trace through the underlying Wolter I optic. The optimal values for the parameters are found by solving the linear system of equations creating by setting derivatives of this function with respect to each parameter to zero.

  13. The Galactic Plane Exoplanet Survey (GPX) - an Amateur Designed Transiting Exoplanet Wide-Field Search (Abstract) (United States)

    Benni, P.


    (Abstract only) GPX is designed to search high density star fields where other surveys, such as WASP, HATNet, XO, and KELT would find challenging due to blending of transit like events. Using readily available amateur equipment, a survey telescope (Celestron RASA, 279 mm f/2.2, based in Acton, Massachusetts) was configured first with a SBIG ST-8300M camera then later upgraded to an FLI ML16200 camera and tested under different sampling scenarios with multiple image fields to obtain a 9- to 11-minute cadence per field. The resultant image resolution of GPX is about 2 arcsec/pixel compared to 13.7±23 arcsec/pixel of the aforementioned surveys and the future TESS space telescope exoplanet survey.

  14. Images of women in STEM fields


    Cho, S.; Goodman, M; Oppenheimer, B.; J. Codling; Robinson, T.


    This study investigated how eighth-grade students perceived images of women in STEM and non-STEM careers. Thirty-six images were posted on-line; we measured five characteristics of each image. Forty students participated in the study. We found that there were significant differences in attractiveness, creativity, and intelligence between STEM and non-STEM images. There were no significant differences for good at her job and organization. In addition, there were no significant differences amon...

  15. Regional neural response differences in the determination of faces or houses positioned in a wide visual field. (United States)

    Wang, Bin; Yan, Tianyi; Wu, Jinglong; Chen, Kewei; Imajyo, Satoshi; Ohno, Seiichiro; Kanazawa, Susumu


    In human visual cortex, the primary visual cortex (V1) is considered to be essential for visual information processing; the fusiform face area (FFA) and parahippocampal place area (PPA) are considered as face-selective region and places-selective region, respectively. Recently, a functional magnetic resonance imaging (fMRI) study showed that the neural activity ratios between V1 and FFA were constant as eccentricities increasing in central visual field. However, in wide visual field, the neural activity relationships between V1 and FFA or V1 and PPA are still unclear. In this work, using fMRI and wide-view present system, we tried to address this issue by measuring neural activities in V1, FFA and PPA for the images of faces and houses aligning in 4 eccentricities and 4 meridians. Then, we further calculated ratio relative to V1 (RRV1) as comparing the neural responses amplitudes in FFA or PPA with those in V1. We found V1, FFA, and PPA showed significant different neural activities to faces and houses in 3 dimensions of eccentricity, meridian, and region. Most importantly, the RRV1s in FFA and PPA also exhibited significant differences in 3 dimensions. In the dimension of eccentricity, both FFA and PPA showed smaller RRV1s at central position than those at peripheral positions. In meridian dimension, both FFA and PPA showed larger RRV1s at upper vertical positions than those at lower vertical positions. In the dimension of region, FFA had larger RRV1s than PPA. We proposed that these differential RRV1s indicated FFA and PPA might have different processing strategies for encoding the wide field visual information from V1. These different processing strategies might depend on the retinal position at which faces or houses are typically observed in daily life. We posited a role of experience in shaping the information processing strategies in the ventral visual cortex.

  16. Wide-Field InfraRed Survey Telescope (WFIRST) Mission and Synergies with LISA and LIGO-Virgo (United States)

    Gehrels, N.; Spergel, D.


    The Wide-Field InfraRed Survey Telescope (WFIRST) is a NASA space mission in study for launch in 2024. It has a 2.4 m telescope, wide-field IR instrument operating in the 0.7 - 2.0 micron range and an exoplanet imaging coronagraph instrument operating in the 400 - 1000 nm range. The observatory will perform galaxy surveys over thousands of square degrees to J=27 AB for dark energy weak lensing and baryon acoustic oscillation measurements and will monitor a few square degrees for dark energy SN Ia studies. It will perform microlensing observations of the galactic bulge for an exoplanet census and direct imaging observations of nearby exoplanets with a pathfinder coronagraph. The mission will have a robust and wellfunded guest observer program for 25% of the observing time. WFIRST will be a powerful tool for time domain astronomy and for coordinated observations with gravitational wave experiments. Gravitational wave events produced by mergers of nearby binary neutron stars (LIGO-Virgo) or extragalactic supermassive black hole binaries (LISA) will produce electromagnetic radiation that WFIRST can observe.

  17. Deep wide-field near-infrared survey of the Carina Nebula (United States)

    Preibisch, T.; Ratzka, T.; Kuderna, B.; Ohlendorf, H.; King, R. R.; Hodgkin, S.; Irwin, M.; Lewis, J. R.; McCaughrean, M. J.; Zinnecker, H.


    Context. The Great Nebula in Carina is a giant H ii region and a superb location in which to study the physics of violent massive star formation, but the population of the young low-mass stars remained very poorly studied until recently. Aims: Our aim was to produce a near-infrared survey that is deep enough to detect the full low-mass stellar population (i.e. down to ≈0.1 M⊙ and for extinctions up to AV ≈ 15 mag) and wide enough to cover all important parts of the Carina Nebula complex (CNC), including the clusters Tr 14, 15, and 16 as well as the South Pillars region. Methods: We used HAWK-I at the ESO VLT to survey the central ≈0.36 deg2 area of the Carina Nebula. These data reveal more than 600 000 individual infrared sources down to magnitudes as faint as J ≈ 23, H ≈ 22, and Ks ≈ 21. The results of a recent deep X-ray survey (which is complete down to stellar masses of ~0.5-1 M⊙) are used to distinguish between young stars in Carina and background contaminants. We analyze color - magnitude diagrams (CMDs) to derive information about the ages and masses of the low-mass stars. Results: The ages of the low-mass stars agree with previous age estimates for the massive stars. The CMD suggests that ≈3200 of the X-ray selected stars have masses of M∗ ≥ 1 M⊙; this number is in good agreement with extrapolations of the field IMF based on the number of high-mass (M∗ ≥ 20 M⊙) stars and shows that there is no deficit of low-mass stars in the CNC. The HAWK-I images confirm that about 50% of all young stars in Carina are in a widely distributed, non-clustered spatial configuration. Narrow-band images reveal six molecular hydrogen emission objects (MHOs) that trace jets from embedded protostars. However, none of the optical HH objects shows molecular hydrogen emission, suggesting that the jet-driving protostars are located very close to the edges of the globules in which they are embedded. Conclusions: The near-infrared excess fractions for the

  18. Imaging FTS: A Different Approach to Integral Field Spectroscopy

    Directory of Open Access Journals (Sweden)

    Laurent Drissen


    Full Text Available Imaging Fourier transform spectroscopy (iFTS is a promising, although technically very challenging, option for wide-field hyperspectral imagery. We present in this paper an introduction to the iFTS concept and its advantages and drawbacks, as well as examples of data obtained with a prototype iFTS, SpIOMM, attached to the 1.6 m telescope of the Observatoire du Mont-Mégantic: emission line ratios in the spiral galaxy NGC 628 and absorption line indices in the giant elliptical M87. We conclude by introducing SpIOMM's successor, SITELLE, which will be installed at the Canada-France-Hawaii Telescope in 2014.

  19. HDR Pathological Image Enhancement Based on Improved Bias Field Correction and Guided Image Filter (United States)

    Zhu, Ganzheng; Li, Siqi; Gong, Shang; Yang, Benqiang; Zhang, Libo


    Pathological image enhancement is a significant topic in the field of pathological image processing. This paper proposes a high dynamic range (HDR) pathological image enhancement method based on improved bias field correction and guided image filter (GIF). Firstly, a preprocessing including stain normalization and wavelet denoising is performed for Haematoxylin and Eosin (H and E) stained pathological image. Then, an improved bias field correction model is developed to enhance the influence of light for high-frequency part in image and correct the intensity inhomogeneity and detail discontinuity of image. Next, HDR pathological image is generated based on least square method using low dynamic range (LDR) image, H and E channel images. Finally, the fine enhanced image is acquired after the detail enhancement process. Experiments with 140 pathological images demonstrate the performance advantages of our proposed method as compared with related work. PMID:28116303

  20. KOALA: a wide-field 1000 element integral-field unit for the Anglo-Australian Telescope (United States)

    Ellis, S. C.; Ireland, M.; Lawrence, J. S.; Tims, J.; Staszak, N.; Brzeski, J.; Parker, Q. A.; Sharp, R.; Bland-Hawthorn, J.; Case, S.; Colless, M.; Croom, S.; Couch, W.; De Marco, O.; Glazebrook, K.; Saunders, W.; Webster, R.; Zucker, D. B.


    KOALA, the Kilofibre Optimised Astronomical Lenslet Array, is a wide-field, high efficiency integral field unit being designed for use with the bench mounted AAOmega spectrograph on the AAT. KOALA will have 1000 fibres in a rectangular array with a selectable field of view of either 1390 or 430 sq. arcseconds with a spatial sampling of 1.25" or 0.7" respectively. To achieve this KOALA will use a telecentric double lenslet array with interchangeable fore-optics. The IFU will feed AAOmega via a 31m fibre run. The efficiency of KOALA is expected to be ≍ 52% at 3700A and ≍ 66% at 6563°Å with a throughput of > 52% over the entire wavelength range.

  1. Working towards Usable Forms on the World Wide Web: Optimizing Date Entry Input Fields

    Directory of Open Access Journals (Sweden)

    Javier A. Bargas-Avila


    Full Text Available When an interactive form in the world wide web requires users to fill in exact dates, this can be implemented in several ways. This paper discusses an empirical online study with n = 172 participants which compared six different versions to design input fields for date entries. The results revealed that using a drop-down menu is best when format errors must be avoided, whereas using only one input field and placing the format requirements left or inside the text box led to faster completion time and higher user satisfaction.

  2. The biocytin wide-field bipolar cell in the rabbit retina selectively contacts blue cones


    MacNeil, Margaret A.; Gaul, Paulette A.


    The biocytin wide-field bipolar cell in rabbit retina is a sparsely populated ON cone bipolar cell with a broad dendritic arbor that does not contact all cones in its dendritic field. The purpose of our study was to identify the cone types that this cell contacts. We identified the bipolar cells by selective uptake of biocytin, labeled the cones with peanut agglutinin and then used antibodies against blue cone opsin and red-green cone opsin to identify the individual cone types. The biocytin-...

  3. Ground-based complex for detection and investigation of fast optical transients in wide field (United States)

    Molinari, Emilio; Beskin, Grigory; Bondar, Sergey; Karpov, Sergey; Plokhotnichenko, Vladimir; de-Bur, Vjacheslav; Greco, Guiseppe; Bartolini, Corrado; Guarnieri, Adriano; Piccioni, Adalberto


    To study short stochastic optical flares of different objects (GRBs, SNs, etc) of unknown localizations as well as NEOs it is necessary to monitor large regions of sky with high time resolution. We developed a system which consists of wide-field camera (FOW is 400-600 sq.deg.) using TV-CCD with time resolution of 0.13 s to record and classify optical transients, and a fast robotic telescope aimed to perform their spectroscopic and photometric investigation just after detection. Such two telescope complex TORTOREM combining wide-field camera TORTORA and robotic telescope REM operated from May 2006 at La Silla ESO observatory. Some results of its operation, including first fast time resolution study of optical transient accompanying GRB and discovery of its fine time structure, are presented. Prospects for improving the complex efficiency are given.

  4. Focusing, imaging, and ATR for the Gotcha 2008 wide angle SAR collection (United States)

    Gianelli, Christopher D.; Xu, Luzhou


    The following work discusses IAA's approach to tackling the wide angle, circular spotlight, synthetic aperture radar (SAR) problem from the 2008 Gotcha wide angle SAR data set, which is publicly released, with unlimited distribution. This data set comes with a MATLAB image formation routine and attendant graphical user inter- face (GUI). We begin by introducing a simple approach to focusing the collected phase history data that utilizes point targets (quadrahedral targets) present in the scene. Two SAR imaging algorithms are then presented, namely, the data-independent backprojection (BP) algorithm and the data-adaptive sparse learning via itera- tive minimization (SLIM) algorithm. These imaging approaches are compared using the 2008 Gotcha wide angle SAR data to perform both a clutter discrimination experiment, as well as an automatic target recognition (ATR) experiment. The ATR system is composed of a target pose and target center estimation preprocessing system, and includes a novel target feature for the final classification stage. Empirical results obtained by applying the focusing approach and imaging algorithms to the 2008 Gotcha wide angle SAR data set are presented and described. The results presented highlight the benefit of applying the SLIM algorithm over its data-independent counterpart, as well as the utility of the novel target feature.

  5. Airborne Open Polar/Imaging Nephelometer for Ice Particles in Cirrus Clouds and Aerosols Field Campaign Report

    Energy Technology Data Exchange (ETDEWEB)

    Martins, JV [Univ. of Maryland, College Park, MD (United States)


    The Open Imaging Nephelometer (O-I-Neph) instrument is an adaptation of a proven laboratory instrument built and tested at the University of Maryland, Baltimore County (UMBC), the Polarized Imaging Nephelometer (PI-Neph). The instrument design of both imaging nephelometers uses a narrow-beam laser source and a wide-field-of-view imaging camera to capture the entire scattering-phase function in one image, quasi-instantaneously.

  6. Monitoring with high temporal resolution to search for optical transients in the wide field (United States)

    Beskin, Grigory; Bondar, Sergey; Ivanov, Evgeny; Karpov, Sergey; Katkova, Elena; Pozanenko, Alexei; Guarnieri, Adriano; Bartolini, Corrado; Piccioni, Adalberto; Greco, Giuseppe; Molinari, Emilio; Covino, Stefano


    In order to detect and investigate short stochastic optical flares from a number of variable astrophysical objects (GRBs, SNs, flare stars, CVs, X-Ray binaries) of unknown localizations as well as near-earth objects (NEOs), both natural and artificial, it is necessary to perform the systematic monitoring of large regions of the sky with high temporal resolution. Here we describe the design of a system able to perform such a task, which consists of a wide-field camera with high time resolution able to detect and classify the transient events on a subsecond time scale, and a fast robotic telescope aimed to perform their detailed investigation. In a last few years we've created the prototype FAVOR wide-field camera, placed at North Caucasus near Russian 6-m telescope, and a complete two-telescope complex TORTOREM, combining TORTORA wide-field camera with REM robotic telescope and placed at La Silla ESO observatory. Its technical parameters and first results of operation are described.

  7. Extracting flat-field images from scene-based image sequences using phase correlation

    Energy Technology Data Exchange (ETDEWEB)

    Caron, James N., E-mail: [Research Support Instruments, 4325-B Forbes Boulevard, Lanham, Maryland 20706 (United States); Montes, Marcos J. [Naval Research Laboratory, Code 7231, 4555 Overlook Avenue, SW, Washington, DC 20375 (United States); Obermark, Jerome L. [Naval Research Laboratory, Code 8231, 4555 Overlook Avenue, SW, Washington, DC 20375 (United States)


    Flat-field image processing is an essential step in producing high-quality and radiometrically calibrated images. Flat-fielding corrects for variations in the gain of focal plane array electronics and unequal illumination from the system optics. Typically, a flat-field image is captured by imaging a radiometrically uniform surface. The flat-field image is normalized and removed from the images. There are circumstances, such as with remote sensing, where a flat-field image cannot be acquired in this manner. For these cases, we developed a phase-correlation method that allows the extraction of an effective flat-field image from a sequence of scene-based displaced images. The method uses sub-pixel phase correlation image registration to align the sequence to estimate the static scene. The scene is removed from sequence producing a sequence of misaligned flat-field images. An average flat-field image is derived from the realigned flat-field sequence.

  8. Extracting flat-field images from scene-based image sequences using phase correlation. (United States)

    Caron, James N; Montes, Marcos J; Obermark, Jerome L


    Flat-field image processing is an essential step in producing high-quality and radiometrically calibrated images. Flat-fielding corrects for variations in the gain of focal plane array electronics and unequal illumination from the system optics. Typically, a flat-field image is captured by imaging a radiometrically uniform surface. The flat-field image is normalized and removed from the images. There are circumstances, such as with remote sensing, where a flat-field image cannot be acquired in this manner. For these cases, we developed a phase-correlation method that allows the extraction of an effective flat-field image from a sequence of scene-based displaced images. The method uses sub-pixel phase correlation image registration to align the sequence to estimate the static scene. The scene is removed from sequence producing a sequence of misaligned flat-field images. An average flat-field image is derived from the realigned flat-field sequence.

  9. Wide-band IR imaging in the NIR-MIR-FIR regions for in situ analysis of frescoes (United States)

    Daffara, C.; Pezzati, L.; Ambrosini, D.; Paoletti, D.; Di Biase, R.; Mariotti, P. I.; Frosinini, C.


    Imaging methods offer several advantages in the field of conservation allowing to perform non-invasive inspection of works of art. In particular, non-invasive techniques based on imaging in different infrared (IR) regions are widely used for the investigation of paintings. Using radiation beyond the visible range, different characteristics of the inspected artwork may be revealed according to the bandwidth acquired. In this paper we present the recent results of a joint project among the two research institutes DIMEG and CNR-INO, and the restoration facility Opificio delle Pietre Dure, concerning the wide-band integration of IR imaging techniques, in the spectral ranges NIR 0.8-2.5 μm, MIR 3-5 μm, and FIR 8-12 μm, for in situ analysis of artworks. A joint, multi-mode use of reflection and thermal bands is proposed for the diagnostics of mural paintings, and it is demonstrated to be an effective tool in inspecting the layered structure. High resolution IR reflectography and, to a greater extent, IR imaging in the 3-5 μm band, are effectively used to characterize the superficial layer of the fresco and to analyze the stratigraphy of different pictorial layers. IR thermography in the 8-12 μm band is used to characterize the support deep structure. The integration of all the data provides a multi- layered and multi-spectral representation of the fresco that yields a comprehensive analysis.

  10. Deconvolution of wide field-of-view radiometer measurements of earth-emitted radiation. I - Theory (United States)

    Smith, G. L.; Green, R. N.


    The theory of deconvolution of wide field-of-view (WFOV) radiometer measurements of earth-emitted radiation provides a technique by which the resolution of such measurements can be enhanced to provide radiant exitance at the top of the atmosphere with a finer resolution than the field of view. An analytical solution for the earth-emitted radiant exitance in terms of WFOV radiometer measurements is derived for the nonaxisymmetric (or regional) case, in which the measurements and radiant exitance are considered to be functions of both latitude and longitude. This solution makes it possible to deconvolve a set of WFOV radiometer measurements of earth-emitted radiation and obtain information with a finer resolution than the instantaneous field of view of the instrument. It is shown that there are tradeoffs involved in the selection between WFOV and scanning radiometers.

  11. Enterprise-wide PACS: beyond radiology, an architecture to manage all medical images. (United States)

    Bandon, David; Lovis, Christian; Geissbühler, Antoine; Vallée, Jean-Paul


    Picture archiving and communication systems (PACS) have the vocation to manage all medical images acquired within the hospital. To address the various situations encountered in the imaging specialties, the traditional architecture used for the radiology department has to evolve. We present our preliminarily results toward an enterprise-wide PACS intended to support all kind of image production in medicine, from biomolecular images to whole-body pictures. Our solution is based on an existing radiologic PACS system from which images are distributed through an electronic patient record to all care facilities. This platform is enriched with a flexible integration framework supporting digital image communication in medicine (DICOM) and DICOM-XML formats. In addition, a generic workflow engine highly customizable is used to drive work processes. Echocardiology; hematology; ear, nose, and throat; and dermatology, including wounds, follow-up is the first implemented extensions outside of radiology. We also propose a global strategy for further developments based on three possible architectures for an enterprise-wide PACS.

  12. Wide-field surface plasmon microscopy of nano- and microparticles: features, benchmarking, limitations, and bioanalytical applications (United States)

    Nizamov, Shavkat; Scherbahn, Vitali; Mirsky, Vladimir M.


    Detection of nano- and micro-particles is an important task for chemical analytics, food industry, biotechnology, environmental monitoring and many other fields of science and industry. For this purpose, a method based on the detection and analysis of minute signals in surface plasmon resonance images due to adsorption of single nanopartciles was developed. This new technology allows one a real-time detection of interaction of single nano- and micro-particles with sensor surface. Adsorption of each nanoparticle leads to characteristic diffraction image whose intensity depends on the size and chemical composition of the particle. The adsorption rate characterizes volume concentration of nano- and micro-particles. Large monitored surface area of sensor enables a high dynamic range of counting and to a correspondingly high dynamic range in concentration scale. Depending on the type of particles and experimental conditions, the detection limit for aqueous samples can be below 1000 particles per microliter. For application of method in complex media, nanoparticle images are discriminated from image perturbations due to matrix components. First, the characteristic SPRM images of nanoparticles (templates) are collected in aqueous suspensions or spiked real samples. Then, the detection of nanoparticles in complex media using template matching is performed. The detection of various NPs in consumer products like cosmetics, mineral water, juices, and wines was shown at sub-ppb level. The method can be applied for ultrasensitive detection and analysis of nano- and micro-particles of biological (bacteria, viruses, endosomes), biotechnological (liposomes, protein nanoparticles for drug delivery) or technical origin.

  13. Backscanning step and stare imaging system with high frame rate and wide coverage. (United States)

    Sun, Chongshang; Ding, Yalin; Wang, Dejiang; Tian, Dapeng


    Step and stare imaging with staring arrays has become the main approach to realizing wide area coverage and high resolution imagery of potential targets. In this paper, a backscanning step and stare imaging system is described. Compared with traditional step and stare imaging systems, this system features a much higher frame rate by using a small-sized array. In order to meet the staring requirements, a fast steering mirror is employed to provide backscan motion to compensate for the image motion caused by the continuously scanning of the gimbal platform. According to the working principle, the control system is designed to step/stare the line of sight at a high frame rate with a high accuracy. Then a proof-of-concept backscanning step and stare imaging system is established with a CMOS camera. Finally, the modulation transfer function of the imaging system is measured by the slanted-edge method, and a quantitative analysis is made to evaluate the performance of image motion compensation. Experimental results confirm that both high frame rate and image quality improvement can be achieved by adopting this method.

  14. Analysis of Craniofacial Images using Computational Atlases and Deformation Fields


    Ólafsdóttir, Hildur; Ersbøll, Bjarne Kjær; Larsen, Rasmus


    The topic of this thesis is automatic analysis of craniofacial images. The methods proposed and applied contribute to the scientific knowledge about different craniofacial anomalies, in addition to providing tools for detailed and robust analysis of craniofacial images for clinical and research purposes. The basis for most of the applications is non-rigid image registration. This approach brings one image into the coordinate system of another resulting in a deformation field describing the an...

  15. KOALA, a wide-field 1000 element integral-field unit for the Anglo-Australian Telescope: assembly and commissioning (United States)

    Zhelem, Ross; Brzeski, Jurek; Case, Scott; Churilov, Vladimir; Ellis, Simon; Farrell, Tony; Green, Andrew; Heng, Anthony; Horton, Anthony; Ireland, Michael; Jones, Damien; Klauser, Urs; Lawrence, Jon; Miziarski, Stan; Orr, David; Pai, Naveen; Staszak, Nick; Tims, Julia; Vuong, Minh; Waller, Lew; Xavier, Pascal


    The KOALA optical fibre feed for the AAOmega spectrograph has been commissioned at the Anglo-Australian Telescope. The instrument samples the reimaged telescope focal plane at two scales: 1.23 arcsec and 0.70 arcsec per image slicing hexagonal lenslet over a 49x27 and 28x15 arcsec field of view respectively. The integral field unit consists of 2D hexagonal and circular lenslet arrays coupling light into 1000 fibres with 100 micron core diameter. The fibre run is over 35m long connecting the telescope Cassegrain focus with the bench mounted spectrograph room where all fibres are reformatted into a one-dimensional slit. Design and assembly of the KOALA components, engineering challenges encountered, and commissioning results are discussed.

  16. Fresnel zone plate light field spectral imaging simulation (United States)

    Hallada, Francis D.; Franz, Anthony L.; Hawks, Michael R.


    Through numerical simulation, we have demonstrated a novel snapshot spectral imaging concept using binary diffractive optics. Binary diffractive optics, such as Fresnel zone plates (FZP) or photon sieves, can be used as the single optical element in a spectral imager that conducts both imaging and dispersion. In previous demonstrations of spectral imaging with diffractive optics, the detector array was physically translated along the optic axis to measure different image formation planes. In this new concept the wavelength-dependent images are constructed synthetically, by using integral photography concepts commonly applied to light field (plenoptic) cameras. Light field cameras use computational digital refocusing methods after exposure to make images at different object distances. Our concept refocuses to make images at different wavelengths instead of different object distances. The simulations in this study demonstrate this concept for an imager designed with a FZP. Monochromatic light from planar sources is propagated through the system to a measurement plane using wave optics in the Fresnel approximation. Simple images, placed at optical infinity, are illuminated by monochromatic sources and then digitally refocused to show different spectral bins. We show the formation of distinct images from different objects, illuminated by monochromatic sources in the VIS/NIR spectrum. Additionally, this concept could easily be applied to imaging in the MWIR and LWIR ranges. In conclusion, this new type of imager offers a rugged and simple optical design for snapshot spectral imaging and warrants further development.

  17. A wide-field suprachoroidal retinal prosthesis is stable and well tolerated following chronic implantation. (United States)

    Villalobos, Joel; Nayagam, David A X; Allen, Penelope J; McKelvie, Penelope; Luu, Chi D; Ayton, Lauren N; Freemantle, Alexia L; McPhedran, Michelle; Basa, Meri; McGowan, Ceara C; Shepherd, Robert K; Williams, Chris E


    The safety of chronic implantation of a retinal prosthesis in the suprachoroidal space has not been established. This study aimed to determine the safety of a wide-field suprachoroidal electrode array following chronic implantation using histopathologic techniques and electroretinography. A platinum electrode array in a wide silicone substrate was implanted unilaterally in the suprachoroidal space in adult cats (n = 7). The lead and connector were tunneled out of the orbit and positioned subcutaneously. Postsurgical recovery was assessed using fundus photography and electroretinography (ERG). Following 3 months of passive implantation, the animals were terminated and the eyes assessed for the pathologic response to implantation. The implant was mechanically stable in the suprachoroidal space during the course of the study. The implanted eye showed a transient increase in ERG response amplitude at 2 weeks, which returned to normal by 3 months. Pigmentary changes were observed at the distal end of the implant, near the optic disc. Histopathologic assessment revealed a largely intact retina and a thin fibrous capsule around the suprachoroidal implant cavity. The foreign body response was minimal, with sporadic presence of macrophages and no active inflammation. All implanted eyes were negative for bacterial or fungal infections. A midgrade granuloma and thick fibrous buildup surrounded the extraocular cable. Scleral closure was maintained in six of seven eyes. There were no staphylomas or choroidal incarceration. A wide-field retinal prosthesis was stable and well tolerated during long-term suprachoroidal implantation in a cat model. The surgical approach was reproducible and overall safe.

  18. Non-invasive terahertz field imaging inside parallel plate waveguides

    DEFF Research Database (Denmark)

    Iwaszczuk, Krzysztof; Andryieuski, Andrei; Lavrinenko, Andrei


    We present a non-invasive broadband air photonic method of imaging of the electric field of THz pulses propagating inside a tapered parallel plate waveguide. The method is based on field-enhanced second harmonic generation of the fundamental laser beam in an external electric field. We apply...

  19. Design status of WFCAM: a wide field camera for the UK infrared telescope (United States)

    Henry, David M.; Casali, Mark M.; Montgomery, David; Burch, Keith; Laidlaw, Ken; Ives, Derek J.; Vick, Andrew J. A.; Bridger, Alan; Lunney, David; Adamson, Andrew J.; Rees, Nicholas P.; Chylek, Tomas; Chuter, Timothy C.


    An update on the design status of the UKIRT Wide Field Camera (WFCAM) is presented. WFCAM is a wide field infrared camera for the UK Infrared Telescope, designed to produce large scale infrared surveys. The complete system consists of a new IR camera with integral autoguider and a new tip/tilt secondary mirror unit. WFCAM is being designed and built by a team at the UK Astronomy Technology Centre in Edinburgh, supported by the Joint Astronomy Centre in Hawaii. The camera uses a novel quasi-Schmidt camera type design, with the camera mounted above the UKIRT primary mirror. The optical system operates over 0.7 - 2.4 μm and has a large corrected field of view of 0.9° diameter. The focal plane is sparsely populated with 4 2K x 2K Rockwell HAWAII-2 MCT array detectors, giving a pixel scale of 0.4 arcsec/pixel. A separate autoguider CCD is integrated into the focal plane unit. Parallel detector controllers are used, one for each of the four IR arrays and a fifth for the autoguider CCD.

  20. SHOK—The First Russian Wide-Field Optical Camera in Space (United States)

    Lipunov, V. M.; Gorbovskoy, E. S.; Kornilov, V. G.; Panasyuk, M. I.; Amelushkin, A. M.; Petrov, V. L.; Yashin, I. V.; Svertilov, S. I.; Vedenkin, N. N.


    Onboard the spacecraft Lomonosov is established two fast, fixed, very wide-field cameras SHOK. The main goal of this experiment is the observation of GRB optical emission before, synchronously, and after the gamma-ray emission. The field of view of each of the cameras is placed in the gamma-ray burst detection area of other devices located onboard the "Lomonosov" spacecraft. SHOK provides measurements of optical emissions with a magnitude limit of ˜ 9-10m on a single frame with an exposure of 0.2 seconds. The device is designed for continuous sky monitoring at optical wavelengths in the very wide field of view (1000 square degrees each camera), detection and localization of fast time-varying (transient) optical sources on the celestial sphere, including provisional and synchronous time recording of optical emissions from the gamma-ray burst error boxes, detected by the BDRG device and implemented by a control signal (alert trigger) from the BDRG. The Lomonosov spacecraft has two identical devices, SHOK1 and SHOK2. The core of each SHOK device is a fast-speed 11-Megapixel CCD. Each of the SHOK devices represents a monoblock, consisting of a node observations of optical emission, the electronics node, elements of the mechanical construction, and the body.

  1. Wide-azimuth angle-domain imaging for anisotropic reverse-time migration

    KAUST Repository

    Sava, Paul C.


    Extended common-image-point gathers (CIP) constructed by wide-azimuth TI wave-equation migration contain all the necessary information for angle decomposition as a function of the reflection and azimuth angles at selected locations in the subsurface. The reflection and azimuth angles are derived from the extended images using analytic relations between the space-lag and time-lag extensions. This post-imaging decomposition requires only information which is already available at the time of migration, i.e. the model parameters and the tilt angles of the TI medium. The transformation amounts to a linear Radon transform applied to the CIPs obtained after the application of the extended imaging condition. If information about the reflector dip is available at the CIP locations, then only two components of the space-lag vectors are required, thus reducing computational cost and increasing the affordability of the method. This efficient angle decomposition method is suitable for wide-azimuth imaging in anisotropic media with arbitrary orientation of the symmetry plane. © 2011 Society of Exploration Geophysicists.

  2. Ulva prolifera monitoring by GF-1 wide field-of-view sensor data (United States)

    Liang, Wenxiu; Li, Junsheng; Zhou, Demin; Shen, Qian; Zhang, Fangfang; Zhang, Haobin


    Ulva prolifera, a kind of green macroalgae, is nontoxic itself, however, its bloom has bad effects on the marine environment, coastal scene, water sports and seashore tourism. Monitoring of the Ulva prolifera by remote sensing technology has the advantages of wide coverage, rapidness, low cost and dynamic monitoring over a long period of time. The GF-1 satellite was launched in April 2013, which provides a new suitable remote sensing data source for monitoring the Ulva prolifera. At present, segmenting image with a threshold is the most widely used method in Ulva prolifera extraction by remote sensing data, because it is simple and easy to operate. However, the threshold value is obtained through visual analysis or using a fixed statistical value, and could not be got automatically. Facing this problem, we proposed a new method, which can obtain the segmentation threshold automatically based on the local maximum gradient value. This method adopted the average NDVI value of local maximum gradient points as the threshold, and could get an appropriate segmentation threshold automatically for each image. The preliminary results showed that this method works well in monitoring Ulva prolifera by GF-1 WFV data.

  3. Plastic optical fiber for wide field-of-view optical wireless receiver (United States)

    Fallah, Hoorieh; Sterckx, Karel; Saengudomlert, Poompat; Mohammed, Waleed S.


    This paper demonstrates a working indoor optical wireless link for smart environment applications. The system utilizes a wide field-of-view (FOV) optical wireless receiver through cleaving the tip of large core plastic optical fibers (POFs) attached to the detector. The quality of the optical link is quantified through bit error rate (BER) measurements. The experimental results show a wide FOV with the uncoded BER in the order of 10-3 for transmission distances up to 35 cm when using two POFs for signal collection. The distance can be improved further by increasing the number of fibers. The transmitted signal format and how the BER measurement is achieved are discussed at length. In addition, details are provided for the design of the electronics to establish the optical wireless link.

  4. Miniaturized high-resolution wide-field contact lens for panretinal photocoagulation

    Directory of Open Access Journals (Sweden)

    Koushan K


    Full Text Available Keyvan Koushan, KV Chalam Department of Ophthalmology, University of Florida College of Medicine, Jacksonville, FL, USA Background and objective: We describe a miniaturized lightweight high-refractive-index panretinal contact lens for diagnostic and therapeutic visualization of the peripheral retina. Instrument design: The miniaturized high-resolution wide-field contact lens includes three optical elements in a light (15 g and miniaturized (16 mm footplate, 24 mm external aperture, and 21 mm vertical height casing contributing to a total dioptric power of +171 diopters. This lens provides up to 165° visualization of the retina for diagnostic and therapeutic applications while allowing easier placement due to its miniaturization. Conclusion: This new lens (50% lighter and 89% smaller improves upon earlier contact lenses for visualization of the peripheral retina. Keywords: contact lens, panretinal photocoagulation, retinal examination, peripheral retina, high resolution view, wide-angle lens, lens

  5. Readout electronics for the Wide Field of view Cherenkov/Fluorescence Telescope Array (United States)

    Zhang, J.; Zhang, S.; Zhang, Y.; Zhou, R.; Bai, L.; Zhang, J.; Huang, J.; Yang, C.; Cao, Z.


    The aim of the Large High Altitude Air Shower Observatory (LHAASO), supported by IHEP of the Chinese Academy of Sciences, is a multipurpose project with a complex detectors array for high energy gamma ray and cosmic ray detection. The Wide Field of view Cherenkov Telescope Array (WFCTA), as one of the components of the LHAASO project, aim to tag each primary particle that causes an air shower. The WFCTA is a portable telescope array used to detect cosmic ray spectra. The design of the readout electronics of the WFCTA is described in this paper Sixteen photomultiplier tubes (PMTs), together with their readout electronics are integrated into a single sub-cluster. To maintain good resolution and linearity over a wide dynamic range, a dual-gain amplification configuration on an analog board is used The digital board contains two 16channel 14-bit, 50 Msps analog-to-digital converters (ADC) and its power consumption, noise level, and relative deviation are all tested.

  6. Testing a new surfactant in a widely-used blood mimic for ultrasound flow imaging. (United States)

    Zhou, Xiaowei; Hoskins, Peter R


    A blood-mimicking fluid developed by Ramnarine et al. has been widely used in flow phantoms for ultrasound flow imaging research, and it has also been cited by IEC 61685 as a reference for making blood-mimicking fluid.However, the surfactant material Synperonic N in this blood-mimicking fluid recipe is phased out from the European market due to environmental issues. The aim of this study is to test whether Synperonic N can be substituted by biodegradable Synperonic A7 in making blood-mimicking fluid for ultrasound flow imaging research. A flow phantom was fabricated to test the blood-mimicking fluid with Synperonic N and Synperonic A7 as surfactants separately. Doppler images and velocity data were collected using a clinical ultrasound scanner under constant and pulsatile flows; and images and measured velocities were compared. It was found that both blood mimics can provide exactly the same images under spectral Doppler ultrasound and colour Doppler ultrasound in terms of their image qualities. The maximum velocities under constant flow were measured by the spectral Doppler ultrasound as 0.4714 ± 0.001 m.s-1 and 0.4644 ± 0.001 m.s-1 for blood-mimicking fluid with Synperonic N and blood-mimicking fluid with Synperonic A7, respectively. Measured velocities using the two different blood-mimicking fluids were statistically different (p flow imaging research.

  7. Super-resolution near field imaging device

    DEFF Research Database (Denmark)


    Super-resolution imaging device comprising at least a first and a second elongated coupling element, each having a first transverse dimension at a first end and a second transverse dimension at a second end and being adapted for guiding light between their respective first and second ends, each...... of the matrix and the second ends of the coupling elements are located at or in a vicinity of the second side of the matrix. The second transverse dimension is larger than the first transverse dimension. A microscope objective system and a microscope comprising the super-resolution imaging device are also...

  8. Wide area 2D/3D imaging development, analysis and applications

    CERN Document Server

    Langmann, Benjamin


    Imaging technology is an important research area and it is widely utilized in a growing number of disciplines ranging from gaming, robotics and automation to medicine. In the last decade 3D imaging became popular mainly driven by the introduction of novel 3D cameras and measuring devices. These cameras are usually limited to indoor scenes with relatively low distances. Benjamin Langmann introduces medium and long-range 2D/3D cameras to overcome these limitations. He reports measurement results for these devices and studies their characteristic behavior. In order to facilitate the application o

  9. Far-field super-resolution imaging of resonant multiples

    KAUST Repository

    Guo, Bowen


    We demonstrate for the first time that seismic resonant multiples, usually considered as noise, can be used for super-resolution imaging in the far-field region of sources and receivers. Tests with both synthetic data and field data show that resonant multiples can image reflector boundaries with resolutions more than twice the classical resolution limit. Resolution increases with the order of the resonant multiples. This procedure has important applications in earthquake and exploration seismology, radar, sonar, LIDAR (light detection and ranging), and ultrasound imaging, where the multiples can be used to make high-resolution images.

  10. Stellar photometry in the inner bulge of M31 using the Hubble Space Telescope wide field camera (United States)

    Rich, R. M.; Mighell, K. J.


    We present photometry of two fields in the M31 bulge imaged with the Hubble Space Telescope (HST) Wide-Field Camara (WFC). The nuclear field (r less than 40 arcsecs = 150 pc) giant branch extends to I = 19.5, M(sub I) = -5 (Cousins system), a full 0.9 mag brighter than the giant-branch tips of metal-poor Galactic globular clusters and M31 halo fields. This is also approximately = 1.5 mag brighter than the giant branches of metal-rich Galactic globular clusters, but is no brighter than Mould's (1986) M31 bulge field 1 kpc from the nucleus. The data also suggest that the brighter stars may be preferentially concentrated to the center. The 648 luminous stars detected in 2 x 10(exp 9) solar luminosity is approximately = 25% that expected from a hypothetical population of evolved asymptotic giant branch (AGB) stars with lifetimes approximately = 10(exp 5) yr, with the cautionary note that we are near the detection limit. The number of bright stars is also consistent with the progeny of blue stragglers, if one uses a lifetime for the thermal-pulsing AGB of 2 x 10(exp 6) yr. We strongly caution that incompleteness becomes severe below I = 19.9 mag and that future surveys are likely to find numbers of bright stars too large to accomodate the blue straggler progeny hypothesis. We have imaged an additional field 2 arcmin = 500 pc south of the nucleus. The brightest stars in this field are also I = 19.5, but bright stars appear less numerous than in the nuclear field. If the population resembles that of the Galactic bulge, then M(sub bol) = -4.5 is a lower limit to the giant-branch tip luminosity; infrared studies should reveal stars 0.5 mag or more brighter. Either high-metallicity or (more likely) age approximately = 10 Gyr may be responsible for the presence of these luminous AGB stars. These observations confirm that previous ground-based infrared studies (e.g., Rich & Mould 1991) very likely detect an extended giant branch and not spurious luminous stars caused by

  11. Active optics and modified-Rumsey wide-field telescopes: MINITRUST demonstrators with vase- and tulip-form mirrors (United States)

    Lemaître, Gérard R.; Montiel, Pierre; Joulié, Patrice; Dohlen, Kjetil; Lanzoni, Patrick


    Wide-field astronomy requires the development of larger aperture telescopes. The optical properties of a three-mirror modified-Rumsey design provide significant advantages when compared to other telescope designs: (i) at any wavelength, the design has a flat field and is anastigmatic; (ii) the system is extremely compact, i.e., it is almost four times shorter than a Schmidt. Compared to the equally compact flat-field Ritchey-Chrétien with a doublet-lens corrector, as developed for the Sloan digital sky survey - and which requires the polishing of six optical surfaces - the proposed modified-Rumsey design requires only a two-surface polishing and provides a better imaging quality. All the mirrors are spheroids of the hyperboloid type. Starting from the classical Rumsey design, it is shown that the use of all eight available free parameters allows the simultaneous aspherization of the primary and tertiary mirrors by active optics methods from a single deformable substrate. The continuity conditions between the primary and the tertiary hyperbolizations are achieved by an intermediate narrow ring of constant thickness that is not optically used. After the polishing of a double vase form in a spherical shape, the primary-tertiary hyperbolizations are achieved by in situ stressing. The tulip-form secondary is hyperbolized by stress polishing. Other active optics alternatives are possible for a space telescope. The modified-Rumsey design is of interest for developing large space- and ground-based survey telescopes in UV, visible, or IR ranges, such as currently demonstrated with the construction of identical telescopes MINITRUST-1 and -2, f/5 - 2° field of view. Double-pass optical tests show diffraction-limited images.

  12. Wide-Field Multi-Parameter FLIM: long-term minimal invasive observation of proteins in living cells. (United States)

    Vitali, Marco; Picazo, Fernando; Prokazov, Yury; Duci, Alessandro; Turbin, Evgeny; Götze, Christian; Llopis, Juan; Hartig, Roland; Visser, Antonie J W G; Zuschratter, Werner


    Time-domain Fluorescence Lifetime Imaging Microscopy (FLIM) is a remarkable tool to monitor the dynamics of fluorophore-tagged protein domains inside living cells. We propose a Wide-Field Multi-Parameter FLIM method (WFMP-FLIM) aimed to monitor continuously living cells under minimum light intensity at a given illumination energy dose. A powerful data analysis technique applied to the WFMP-FLIM data sets allows to optimize the estimation accuracy of physical parameters at very low fluorescence signal levels approaching the lower bound theoretical limit. We demonstrate the efficiency of WFMP-FLIM by presenting two independent and relevant long-term experiments in cell biology: 1) FRET analysis of simultaneously recorded donor and acceptor fluorescence in living HeLa cells and 2) tracking of mitochondrial transport combined with fluorescence lifetime analysis in neuronal processes.

  13. A flexible wide-field FLIM endoscope utilising blue excitation light for label-free contrast of tissue. (United States)

    Sparks, Hugh; Warren, Sean; Guedes, Joana; Yoshida, Nagisa; Charn, Tze Choong; Guerra, Nadia; Tatla, Taranjit; Dunsby, Christopher; French, Paul


    Fluorescence lifetime imaging (FLIM) has previously been shown to provide contrast between normal and diseased tissue. Here we present progress towards clinical and preclinical FLIM endoscopy of tissue autofluorescence, demonstrating a flexible wide-field endoscope that utilised a low average power blue picosecond laser diode excitation source and was able to acquire ∼mm-scale spatial maps of autofluorescence lifetimes from fresh ex vivo diseased human larynx biopsies in ∼8 seconds using an average excitation power of ∼0.5 mW at the specimen. To illustrate its potential for FLIM at higher acquisition rates, a higher power mode-locked frequency doubled Ti:Sapphire laser was used to demonstrate FLIM of ex vivo mouse bowel at up to 2.5 Hz using 10 mW of average excitation power at the specimen. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Combining wide-field super-resolution microscopy and electron tomography: rendering nanoscopic correlative arrays on subcellular architecture. (United States)

    Braet, Filip; Cheng, Delfine; Huynh, Minh; Henriquez, Jeffrey; Shami, Gerry; Lampe, Marko


    In this chapter, the authors outline in full detail, an uncomplicated approach that enables the combination of wide-field fluorescence super-resolution microscopy with electron tomography, thereby providing an approach that affords the best possible confidence in the structures investigated. The methodical steps to obtain these high-throughput correlative nanoscopic arrays will be visually explored and outlined in detail. The authors will demonstrate the feasibility of the method on cultured Caco-2 colorectal cancer cells that are labeled for filamentous actin. The presented images, morphometric data, and generated models illustrate the strengths of our correlative approach for future advanced structural-biology-oriented questions. Correlative nanoscopy applications can be readily found in which there is a need to reveal biomolecular information at unprecedented resolution on subcellular behavior in various biological and pathobiological processes. © 2014 Elsevier Inc. All rights reserved.

  15. Wide-Field Plates Observations of Stars from Earth Orientation Catalogs (EOC) (United States)

    Chapanov, Y.; Tsvetkova, K.; Tsvetkov, M.; Vondrak, J.; Ron, C.; Stefka, V.


    The Earth Orientation Catalogues (EOCs) are primarily meant to provide stable celestial reference frame in optical wavelengths for deriving Earth Orientation Parameters (EOP) from astrometric observations. The EOCs combine catalogues ARIHIP and TYCHO-2 with the rich observation material (variations of Latitude/Universal Time), obtained during the 20th century in programs of monitoring Earth orientation. Other possible source of information for improving the EOCs is the WFPDB (Wide-Field Plate Database). The number of plates, containing EOCs stars and their distribution in time are determined by means of the search engine of the WFPDB.

  16. Sherlock: An Automated Follow-Up Telescope for Wide-Field Transit Searches (United States)

    Kotredes, Lewis; Charbonneau, David; Looper, Dagny L.; O'Donovan, Francis T.


    The most significant challenge currently facing photometric surveys for transiting gas-giant planets is that of confusion with eclipsing binary systems that mimic the photometric signature. A simple way to reject most forms of these false positives is high-precision, rapid-cadence monitoring of the suspected transit at higher angular resolution and in several filters. We are currently building a system that will perform higher-angular-resolution, multi-color follow-up observations of candidate systems identified by Sleuth (our wide-field transit survey instrument at Palomar), and its two twin system instruments in Tenerife and northern Arizona.

  17. Developments of wide field submillimeter optics and lens antenna-coupled MKID cameras (United States)

    Sekimoto, Y.; Nitta, T.; Karatsu, K.; Sekine, M.; Sekiguchi, S.; Okada, T.; Shu, S.; Noguchi, T.; Naruse, M.; Mitsui, K.; Okada, N.; Tsuzuki, T.; Dominjon, A.; Matsuo, H.


    Wide field cryogenic optics and millimeter-wave Microwave Kinetic Inductance Detector (MKID) cameras with Si lens array have been developed. MKID is a Cooper-pair breaking photon detector and consists of supercon- ducting resonators which enable microwave (~GHz) frequency multiplexing. Antenna-coupled Aluminum CPW resonators are put in a line on a Si substrate to be read by a pair of coaxial cables. A 220 GHz - 600 pixels MKID camera with anti-reflection (AR) coated Si lens has been demonstrated in an 0.1 K cryostat. A compact cryogenic system with high refractive index materials has been developed for the MKID camera.

  18. A new system for quantitative evaluation of infant gaze capabilities in a wide visual field. (United States)

    Pratesi, Andrea; Cecchi, Francesca; Beani, Elena; Sgandurra, Giuseppina; Cioni, Giovanni; Laschi, Cecilia; Dario, Paolo


    The visual assessment of infants poses specific challenges: many techniques that are used on adults are based on the patient's response, and are not suitable for infants. Significant advances in the eye-tracking have made this assessment of infant visual capabilities easier, however, eye-tracking still requires the subject's collaboration, in most cases and thus limiting the application in infant research. Moreover, there is a lack of transferability to clinical practice, and thus it emerges the need for a new tool to measure the paradigms and explore the most common visual competences in a wide visual field. This work presents the design, development and preliminary testing of a new system for measuring infant's gaze in the wide visual field called CareToy C: CareToy for Clinics. The system is based on a commercial eye tracker (SmartEye) with six cameras running at 60 Hz, suitable for measuring an infant's gaze. In order to stimulate the infant visually and audibly, a mechanical structure has been designed to support five speakers and five screens at a specific distance (60 cm) and angle: one in the centre, two on the right-hand side and two on the left (at 30° and 60° respectively). Different tasks have been designed in order to evaluate the system capability to assess the infant's gaze movements during different conditions (such as gap, overlap or audio-visual paradigms). Nine healthy infants aged 4-10 months were assessed as they performed the visual tasks at random. We developed a system able to measure infant's gaze in a wide visual field covering a total visual range of ±60° from the centre with an intermediate evaluation at ±30°. Moreover, the same system, thanks to different integrated software, was able to provide different visual paradigms (as gap, overlap and audio-visual) assessing and comparing different visual and multisensory sub-competencies. The proposed system endowed the integration of a commercial eye-tracker into a purposive setup in

  19. The High-Speed and Wide-Field TORTORA Camera: description & results . (United States)

    Greco, G.; Beskin, G.; Karpov, S.; Guarnieri, A.; Bartolini, C.; Bondar, S.; Piccioni, A.; Molinari, E.

    We present the description and the most significant results of the wide-field and ultra-fast TORTORA camera devoted to the investigation of rapid changes in light intensity in a phenomenon occurring within an extremely short period of time and randomly distributed over the sky. In particular, the ground-based TORTORA observations synchronized with the gamma -ray BAT telescope on board of the Swift satellite has permitted to trace the optical burst time-structure of the Naked-Eye GRB 080319B with an unprecedented level of accuracy.

  20. Micrometeoroid Impacts on the Hubble Space Telescope Wide Field and Planetary Camera 2: Larger Particles (United States)

    Kearsley, A. T.; Grime, G. W.; Webb, R. P.; Jeynes, C.; Palitsin, V.; Colaux, J. L.; Ross, D. K.; Anz-Meador, P.; Liou, J. C.; Opiela, J.; hide


    The Wide Field and Planetary Camera 2 (WFPC2) was returned from the Hubble Space Telescope (HST) by shuttle mission STS-125 in 2009. In space for 16 years, the surface accumulated hundreds of impact features on the zinc orthotitanate paint, some penetrating through into underlying metal. Larger impacts were seen in photographs taken from within the shuttle orbiter during service missions, with spallation of paint in areas reaching 1.6 cm across, exposing alloy beneath. Here we describe larger impact shapes, the analysis of impactor composition, and the micrometeoroid (MM) types responsible.

  1. Infrared Imaging Spectroscopy Using Massively Multiplexed Slit-Based Techniques and Sub-Field Motion Correction (United States)

    Schad, Thomas; Lin, Haosheng


    Targeting dynamic spatially extended phenomena in the upper solar atmosphere, a new instrument concept has been developed and demonstrated at the Dunn Solar Telescope in New Mexico, USA, which provides wide-field, rapid-scanning, high-resolution imaging spectroscopy of the neutral helium λ10830 spectral triplet. The instrument combines a narrowband imaging channel with a novel cospatial grating-based spectrograph with 17 parallel long slits that are simultaneously imaged on a single HgCdTe detector. Over a 175'' × 125'' field of view, a temporal cadence of 8.5 s is achieved between successive maps that critically sample the diffraction limit of the Dunn Solar Telescope at 1083 nm (1.22 λ/D = 0.36'') and provide a resolving power (R = λ / δλ) up to {≈} 25{,}000 with a 1 nm bandwidth ( i.e. 275 km s^{-1} Doppler coverage). Capitalizing on the strict simultaneity of the narrowband channel relative to each spectral image (acquired at a rate of 9.53 Hz), this work demonstrates that sub-field image motion introduced by atmospheric seeing may be corrected post-facto in each mapped spectral data cube. This instrument furnishes essential infrared spectral imaging capabilities for current investigations while pioneering techniques for high-resolution wide-field time-domain solar astronomy.

  2. Multiscale vector fields for image pattern recognition (United States)

    Low, Kah-Chan; Coggins, James M.


    A uniform processing framework for low-level vision computing in which a bank of spatial filters maps the image intensity structure at each pixel into an abstract feature space is proposed. Some properties of the filters and the feature space are described. Local orientation is measured by a vector sum in the feature space as follows: each filter's preferred orientation along with the strength of the filter's output determine the orientation and the length of a vector in the feature space; the vectors for all filters are summed to yield a resultant vector for a particular pixel and scale. The orientation of the resultant vector indicates the local orientation, and the magnitude of the vector indicates the strength of the local orientation preference. Limitations of the vector sum method are discussed. Investigations show that the processing framework provides a useful, redundant representation of image structure across orientation and scale.

  3. Near-field nano-imager (United States)

    Liu, Boyang (Inventor); Ho, Seng-Tiong (Inventor)


    An imaging device. In one embodiment, the imaging device includes a plurality of first electrode strips in parallel to each other along a first direction x, wherein each first electrode strip has an elongated body with a first surface and an opposite, second surface and a thickness n.sub.1. The imaging device also includes a plurality of second electrode strips in parallel to each other along a second direction y that is substantially perpendicular to the first direction x, wherein each second electrode strip has an elongated body with a first surface and an opposite, second surface and a thickness n.sub.2. The plurality of second electrode strips are positioned apart from the plurality of first electrode strips along a third direction z that is substantially perpendicular to the first direction x and the second direction y such that the plurality of first electrode strips and the plurality of second electrode strips are crossing each other accordingly to form a corresponding number of crossing points. And at each crossing point, a semiconductor component is filled between the second surface of a corresponding first electrode strip and the first surface of a corresponding second electrode strip to form an addressable pixel.

  4. Arctic Clouds Infrared Imaging Field Campaign Report

    Energy Technology Data Exchange (ETDEWEB)

    Shaw, J. A. [Montana State Univ., Bozeman, MT (United States)


    The Infrared Cloud Imager (ICI), a passive thermal imaging system, was deployed at the North Slope of Alaska site in Barrow, Alaska, from July 2012 to July 2014 for measuring spatial-temporal cloud statistics. Thermal imaging of the sky from the ground provides high radiometric contrast during night and polar winter when visible sensors and downward-viewing thermal sensors experience low contrast. In addition to demonstrating successful operation in the Arctic for an extended period and providing data for Arctic cloud studies, a primary objective of this deployment was to validate novel instrument calibration algorithms that will allow more compact ICI instruments to be deployed without the added expense, weight, size, and operational difficulty of a large-aperture onboard blackbody calibration source. This objective was successfully completed with a comparison of the two-year data set calibrated with and without the onboard blackbody. The two different calibration methods produced daily-average cloud amount data sets with correlation coefficient = 0.99, mean difference = 0.0029 (i.e., 0.29% cloudiness), and a difference standard deviation = 0.054. Finally, the ICI instrument generally detected more thin clouds than reported by other ARM cloud products available as of late 2015.


    Energy Technology Data Exchange (ETDEWEB)

    Garcia, E. V. [Lowell Observatory, 1400 West Mars Hill Road, Flagstaff (United States); Dupuy, Trent J. [The University of Texas at Austin, Department of Astronomy, 2515 Speedway C1400, Austin, TX 78712 (United States); Allers, Katelyn N. [Department of Physics and Astronomy, Bucknell University, Lewisburg, PA 17837 (United States); Liu, Michael C. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Deacon, Niall R., E-mail: [Centre for Astrophysics Research, University of Hertfordshire, College Lane, Hatfield, AL1 5TL (United Kingdom)


    We present the results of a Hubble Space Telescope Wide Field Camera 3 (WFC3) imaging survey of 11 of the lowest mass brown dwarfs in the Pleiades known (25–40 M{sub Jup}). These objects represent the predecessors to T dwarfs in the field. Using a semi-empirical binary point-spread function (PSF)-fitting technique, we are able to probe to 0.″ 03 (0.75 pixel), better than 2x the WFC3/UVIS diffraction limit. We did not find any companions to our targets. From extensive testing of our PSF-fitting method on simulated binaries, we compute detection limits which rule out companions to our targets with mass ratios of ≳0.7 and separations ≳4 AU. Thus, our survey is the first to attain the high angular resolution needed to resolve brown dwarf binaries in the Pleiades at separations that are most common in the field population. We constrain the binary frequency over this range of separation and mass ratio of 25–40 M{sub Jup} Pleiades brown dwarfs to be <11% for 1σ (<26% at 2σ). This binary frequency is consistent with both younger and older brown dwarfs in this mass range.


    Energy Technology Data Exchange (ETDEWEB)

    Schneider, Adam C.; Cushing, Michael C. [Department of Physics and Astronomy, University of Toledo, 2801 W. Bancroft St., Toledo, OH 43606 (United States); Kirkpatrick, J. Davy; Gelino, Christopher R. [Infrared Processing and Analysis Center, MS 100-22, California Institute of Technology, Pasadena, CA 91125 (United States); Mace, Gregory N.; Wright, Edward L. [Department of Physics and Astronomy, UCLA, 430 Portola Plaza, Box 951547, Los Angeles, CA 90095-1547 (United States); Eisenhardt, Peter R. [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Dr., Pasadena, CA 91109 (United States); Skrutskie, M. F. [Department of Astronomy, University of Virginia, 530 McCormick Road, Charlottesville, VA 22904 (United States); Griffith, Roger L. [Department of Astronomy and Astrophysics, 525 Davey Lab, The Pennsylvania State University, University Park, PA 16802 (United States); Marsh, Kenneth A., E-mail: [School of Physics and Astronomy, Cardiff University, Cardiff CF24 3AA (United Kingdom)


    We present a sample of brown dwarfs identified with the Wide-field Infrared Survey Explorer (WISE) for which we have obtained Hubble Space Telescope (HST) Wide Field Camera 3 (WFC3) near-infrared grism spectroscopy. The sample (22 in total) was observed with the G141 grism covering 1.10–1.70 μm, while 15 were also observed with the G102 grism, which covers 0.90–1.10 μm. The additional wavelength coverage provided by the G102 grism allows us to (1) search for spectroscopic features predicted to emerge at low effective temperatures (e.g.,ammonia bands) and (2) construct a smooth spectral sequence across the T/Y boundary. We find no evidence of absorption due to ammonia in the G102 spectra. Six of these brown dwarfs are new discoveries, three of which are found to have spectral types of T8 or T9. The remaining three, WISE J082507.35+280548.5 (Y0.5), WISE J120604.38+840110.6 (Y0), and WISE J235402.77+024015.0 (Y1), are the 19th, 20th, and 21st spectroscopically confirmed Y dwarfs to date. We also present HST grism spectroscopy and reevaluate the spectral types of five brown dwarfs for which spectral types have been determined previously using other instruments.

  7. Wide-Field InfraRed Survey Telescope (WFIRST) Slitless Spectrometer: Design, Prototype, and Results (United States)

    Gong, Qian; Content, David; Dominguez, Margaret; Emmett, Thomas; Griesmann, Ulf; Hagopian, John; Kruk, Jeffrey; Marx, Catherine; Pasquale, Bert; Wallace, Thomas; hide


    The slitless spectrometer plays an important role in the Wide-Field InfraRed Survey Telescope (WFIRST) mission for the survey of emission-line galaxies. This will be an unprecedented very wide field, HST quality 3D survey of emission line galaxies. The concept of the compound grism as a slitless spectrometer has been presented previously. The presentation briefly discusses the challenges and solutions of the optical design, and recent specification updates, as well as a brief comparison between the prototype and the latest design. However, the emphasis of this paper is the progress of the grism prototype: the fabrication and test of the complicated diffractive optical elements and powered prism, as well as grism assembly alignment and testing. Especially how to use different tools and methods, such as IR phase shift and wavelength shift interferometry, to complete the element and assembly tests. The paper also presents very encouraging results from recent element tests to assembly tests. Finally we briefly touch the path forward plan to test the spectral characteristic, such as spectral resolution and response.

  8. Non-linear evanescent-field imaging

    Energy Technology Data Exchange (ETDEWEB)

    Oheim, Martin [Laboratory of Neurophysiology and New Microscopies, CNRS FRE 2500, INSERM U 603, Ecole Superieure de Physique et Chimie Industrielles (ESPCI), 10 rue Vauquelin, F-75005 Paris (France); Schapper, Florian [Freie Universitaet Berlin, Institut fuer Experimentalphysik, Arbeitsgruppe Wolf, Arnimallee 14, D-14195 Berlin (Germany)


    Total internal reflection fluorescence (TIRF), a general term that embraces any spectroscopic or microscopic technique based on the evanescent field created by TIR of light, is further establishing itself as an important tool for studying near-surface phenomena. Impingement of a femtosecond-pulsed infrared beam on a reflecting interface creates the conditions for 'macroscopic' evanescent-field two-photon fluorescence excitation. The two-photon fluorescence excitation volume is confined by both the non-linearity of the multi-photon process and the spatial inhomogeneity of the evanescent field. The absence of scattered excitation resulting in a low background and the possibility of simultaneous multi-colour fluorescence excitation should make non-linear evanescent-field excitation particularly attractive for quantitative single-molecule observation and ultra-sensitive screening assays. In this topical review, we survey the requirements, present the current results and explore the potential of this novel non-linear microscopy. (topical review)

  9. An apertureless near-field microscope for fluorescence imaging


    Yang, T. J.; Lessard, Guillaume A.; Quake, Stephen R.


    We describe an apertureless near field microscope for imaging fluorescent samples. Optical contrast is generated by exploiting fluorescent quenching near a metallized atomic force microscope tip. This microscope has been used to image fluorescent latex beads with subdiffraction limit resolution. The use of fluorescence allows us to prove that the contrast mechanism is indeed spectroscopic in origin.

  10. Advanced wide-field surface plasmon microscopy of single adsorbing nanoparticles (United States)

    Nizamov, Shavkat; Scherbahn, Vitali; Mirsky, Vladimir M.


    In-situ detection and characterization of nanoparticles in biological media as well as in food or other complex samples is still a big challenge for existing analytical methods. Here we describe a label-free and cost-effective analytical method for detection of nanoparticles in the concentration range 106 -1010 NPs/ml. The proposed method is based on the surface plasmon resonance microscopy (SPRM) with a large field of view ( 1.3mm2 ). It is able to detect and count adsorbing nanoparticles individually, totally up to the hundreds of thousands of NPs on the sensor surface. At constant diffusion conditions the detection rate is proportional to the number concentration of NPs, this provides an approach to determine the NPs concentration. The adsorption of nanoparticle can be manipulated by the surface functionalization, pH and electrolyte concentration of suspensions. Images of detected nanoparticles can be quantified in order to characterize them individually. The image intensity grows quasi-linearly with nanoparticle size for the given material. However, the size and material of nanoparticle cannot be resolved directly from the image. For determination of chemical composition, SPRM can be assisted by electrochemical analysis. In this case, the gold sensor surface is used both as a resonant media for plasmon microscopy and as a working electrode. Under potential sweep, the adsorbed NPs can be subjected to electrochemical dissolution, which is detected optically. The potential of this conversion characterizes the material of NPs.

  11. Ultrasound versus high field magnetic resonance imaging in rheumatoid arthritis

    DEFF Research Database (Denmark)

    Tan, York Kiat; Østergaard, Mikkel; Bird, Paul


    Over the past decade there have been significant advances in the field of musculoskeletal imaging, especially in the application of ultrasound (US) and magnetic resonance imaging (MRI) to the management of rheumatoid arthritis (RA). Both modalities offer significant advantages over the previous...... standards of clinical examination and radiography, and allow direct visualisation of both joint inflammation and structural damage. Although measuring similar pathology, each of these imaging tools has its own benefits and limitations; understanding these will help researchers and clinicians to determine...

  12. Field power measurements of imaging equipment

    Energy Technology Data Exchange (ETDEWEB)

    McWhinney, Marla; Homan, Gregory; Brown, Richard; Roberson, Judy; Nordman, Bruce; Busch, John


    According to the U.S. Department of Energy, electricity use by non-PC commercial office equipment is growing at an annual rate of nearly 5 percent (AEO 2003). To help address this growth in consumption, U.S. EPA periodically updates its ENERGY STAR specifications as products and markets change. This report presents background research conducted to help EPA update the ENERGY STAR specification for imaging equipment, which covers printers, fax machines, copiers, scanners, and multifunction devices (MFDs). We first estimated the market impact of the current ENERGY STAR imaging specification, finding over 90 percent of the current market complies with the specification. We then analyzed a sample of typical new imaging products, including 11 faxes, 57 printers and 19 copiers/MFD. For these devices we metered power levels in the most common modes: active/ready/sleep/off, and recorded features that would most likely affect energy consumption. Our metering indicates that for many products and speed bins, current models consume substantially less power than the current specification. We also found that for all product categories, power consumption varied most considerably across technology (i.e. inkjet vs. laser). Although inkjet printers consumed less energy than laser printers in active, ready and sleep-mode, they consumed more power on average while off, mostly due to the use of external power supplies. Based on these findings, we developed strategies for the ENERGY STAR program to achieve additional energy reductions. Finally, we present an assessment of manufacturer's ENERGY STAR labeling practices.

  13. A deep ALMA image of the Hubble Ultra Deep Field (United States)

    Dunlop, J. S.; McLure, R. J.; Biggs, A. D.; Geach, J. E.; Michałowski, M. J.; Ivison, R. J.; Rujopakarn, W.; van Kampen, E.; Kirkpatrick, A.; Pope, A.; Scott, D.; Swinbank, A. M.; Targett, T. A.; Aretxaga, I.; Austermann, J. E.; Best, P. N.; Bruce, V. A.; Chapin, E. L.; Charlot, S.; Cirasuolo, M.; Coppin, K.; Ellis, R. S.; Finkelstein, S. L.; Hayward, C. C.; Hughes, D. H.; Ibar, E.; Jagannathan, P.; Khochfar, S.; Koprowski, M. P.; Narayanan, D.; Nyland, K.; Papovich, C.; Peacock, J. A.; Rieke, G. H.; Robertson, B.; Vernstrom, T.; Werf, P. P. van der; Wilson, G. W.; Yun, M.


    We present the results of the first, deep Atacama Large Millimeter Array (ALMA) imaging covering the full ≃4.5 arcmin2 of the Hubble Ultra Deep Field (HUDF) imaged with Wide Field Camera 3/IR on HST. Using a 45-pointing mosaic, we have obtained a homogeneous 1.3-mm image reaching σ1.3 ≃ 35 μJy, at a resolution of ≃0.7 arcsec. From an initial list of ≃50 > 3.5σ peaks, a rigorous analysis confirms 16 sources with S1.3 > 120 μJy. All of these have secure galaxy counterparts with robust redshifts ( = 2.15). Due to the unparalleled supporting data, the physical properties of the ALMA sources are well constrained, including their stellar masses (M*) and UV+FIR star formation rates (SFR). Our results show that stellar mass is the best predictor of SFR in the high-redshift Universe; indeed at z ≥ 2 our ALMA sample contains seven of the nine galaxies in the HUDF with M* ≥ 2 × 1010 M⊙, and we detect only one galaxy at z > 3.5, reflecting the rapid drop-off of high-mass galaxies with increasing redshift. The detections, coupled with stacking, allow us to probe the redshift/mass distribution of the 1.3-mm background down to S1.3 ≃ 10 μJy. We find strong evidence for a steep star-forming 'main sequence' at z ≃ 2, with SFR ∝M* and a mean specific SFR ≃ 2.2 Gyr-1. Moreover, we find that ≃85 per cent of total star formation at z ≃ 2 is enshrouded in dust, with ≃65 per cent of all star formation at this epoch occurring in high-mass galaxies (M* > 2 × 1010 M⊙), for which the average obscured:unobscured SF ratio is ≃200. Finally, we revisit the cosmic evolution of SFR density; we find this peaks at z ≃ 2.5, and that the star-forming Universe transits from primarily unobscured to primarily obscured at z ≃ 4.

  14. On focused fields with maximum electric field components and images of electric dipoles

    NARCIS (Netherlands)

    De Bruin, R.; Urbach, H.P.; Pereira, S.F.


    We study focused fields which, for a given total power and a given numerical aperture, have maximum electric field amplitude in some direction in the focal point and are linearly polarized along this direction. It is shown that the optimum field is identical to the image of an electric dipole with

  15. On focused fields with maximum electric field components and images of electric dipoles

    NARCIS (Netherlands)

    De Bruin, R.; Urbach, H.P.; Pereira, S.F.

    We study focused fields which, for a given total power and a given numerical aperture, have maximum electric field amplitude in some direction in the focal point and are linearly polarized along this direction. It is shown that the optimum field is identical to the image of an electric dipole with

  16. Widely tunable, high peak power ultrafast laser sources in biological imaging (Conference Presentation) (United States)

    Klein, Julien


    Widely tunable ultrafast lasers have enabled a large number of biological imaging techniques including point scanning multiphoton excited fluorescence (MPEF), SHG/THG and stimulated Raman imaging. Tunable ultrafast lasers offer spectral agility, covering the entire relative transparency window in live tissue (700-1300nnm) and flexibility with multi-color, synchronized outputs to support sophisticated label free techniques (e.g. stimulated Raman modalities). More recently newly available high peak power lasers based on Ytterbium technology drive advances in two-photon light-sheet, 3 photon excited fluorescence and holographic patterning for optogenetics photo-stimulation. These laser platforms offer a unique blend of compactness, ease of use and cost efficiency, and ideally complement tunable platforms typically based on Ti:Sapphire and IR optical parametric oscillators (OPO). We present various types of ultrafast laser architectures, link their optical characteristics to key bio-imaging requirements, and present relevant examples and images illustrating their impact in biological science. In particular we review the use of ultrafast lasers in optogenetics and fast in-vivo Calcium imaging deep in mouse brain.

  17. Real-time, wide-area hyperspectral imaging sensors for standoff detection of explosives and chemical warfare agents (United States)

    Gomer, Nathaniel R.; Tazik, Shawna; Gardner, Charles W.; Nelson, Matthew P.


    Hyperspectral imaging (HSI) is a valuable tool for the detection and analysis of targets located within complex backgrounds. HSI can detect threat materials on environmental surfaces, where the concentration of the target of interest is often very low and is typically found within complex scenery. Unfortunately, current generation HSI systems have size, weight, and power limitations that prohibit their use for field-portable and/or real-time applications. Current generation systems commonly provide an inefficient area search rate, require close proximity to the target for screening, and/or are not capable of making real-time measurements. ChemImage Sensor Systems (CISS) is developing a variety of real-time, wide-field hyperspectral imaging systems that utilize shortwave infrared (SWIR) absorption and Raman spectroscopy. SWIR HSI sensors provide wide-area imagery with at or near real time detection speeds. Raman HSI sensors are being developed to overcome two obstacles present in standard Raman detection systems: slow area search rate (due to small laser spot sizes) and lack of eye-safety. SWIR HSI sensors have been integrated into mobile, robot based platforms and handheld variants for the detection of explosives and chemical warfare agents (CWAs). In addition, the fusion of these two technologies into a single system has shown the feasibility of using both techniques concurrently to provide higher probability of detection and lower false alarm rates. This paper will provide background on Raman and SWIR HSI, discuss the applications for these techniques, and provide an overview of novel CISS HSI sensors focusing on sensor design and detection results.

  18. THz near-field imaging of biological tissues employing synchrotronradiation

    Energy Technology Data Exchange (ETDEWEB)

    Schade, Ulrich; Holldack, Karsten; Martin, Michael C.; Fried,Daniel


    Terahertz scanning near-field infrared microscopy (SNIM) below 1 THz is demonstrated. The near-field technique benefits from the broadband and highly brilliant coherent synchrotron radiation (CSR) from an electron storage ring and from a detection method based on locking onto the intrinsic time structure of the synchrotron radiation. The scanning microscope utilizes conical wave guides as near-field probes with apertures smaller than the wavelength. Different cone approaches have been investigated to obtain maximum transmittance. Together with a Martin-Puplett spectrometer the set-up enables spectroscopic mapping of the transmittance of samples well below the diffraction limit. Spatial resolution down to about lambda/40 at 2 wavenumbers (0.06 THz) is derived from the transmittance spectra of the near-field probes. The potential of the technique is exemplified by imaging biological samples. Strongly absorbing living leaves have been imaged in transmittance with a spatial resolution of 130 mu-m at about 12 wave numbers (0.36 THz). The THz near-field images reveal distinct structural differences of leaves from different plants investigated. The technique presented also allows spectral imaging of bulky organic tissues. Human teeth samples of various thicknesses have been imaged between 2 and 20 wavenumbers (between 0.06and 0.6 THz). Regions of enamel and dentin within tooth samples are spatially and spectrally resolved, and buried caries lesions are imaged through both the outer enamel and into the underlying dentin.

  19. Energy weighted x-ray dark-field imaging. (United States)

    Pelzer, Georg; Zang, Andrea; Anton, Gisela; Bayer, Florian; Horn, Florian; Kraus, Manuel; Rieger, Jens; Ritter, Andre; Wandner, Johannes; Weber, Thomas; Fauler, Alex; Fiederle, Michael; Wong, Winnie S; Campbell, Michael; Meiser, Jan; Meyer, Pascal; Mohr, Jürgen; Michel, Thilo


    The dark-field image obtained in grating-based x-ray phase-contrast imaging can provide information about the objects' microstructures on a scale smaller than the pixel size even with low geometric magnification. In this publication we demonstrate that the dark-field image quality can be enhanced with an energy-resolving pixel detector. Energy-resolved x-ray dark-field images were acquired with a 16-energy-channel photon-counting pixel detector with a 1 mm thick CdTe sensor in a Talbot-Lau x-ray interferometer. A method for contrast-noise-ratio (CNR) enhancement is proposed and validated experimentally. In measurements, a CNR improvement by a factor of 1.14 was obtained. This is equivalent to a possible radiation dose reduction of 23%.

  20. A simulation study on image reconstruction in magnetic particle imaging with field-free-line encoding

    CERN Document Server

    Murase, Kenya


    The purpose of this study was to present image reconstruction methods for magnetic particle imaging (MPI) with a field-free-line (FFL) encoding scheme and to propose the use of the maximum likelihood-expectation maximization (ML-EM) algorithm for improving the image quality of MPI. The feasibility of these methods was investigated by computer simulations, in which the projection data were generated by summing up the Fourier harmonics obtained from the MPI signals based on the Langevin function. Images were reconstructed from the generated projection data using the filtered backprojection (FBP) method and the ML-EM algorithm. The effects of the gradient of selection magnetic field (SMF), the strength of drive magnetic field (DMF), the diameter of magnetic nanoparticles (MNPs), and the number of projection data on the image quality of the reconstructed images were investigated. The spatial resolution of the reconstructed images became better with increasing gradient of SMF and with increasing diameter of MNPs u...

  1. Plenoptic Imaging for Three-Dimensional Particle Field Diagnostics.

    Energy Technology Data Exchange (ETDEWEB)

    Guildenbecher, Daniel Robert [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hall, Elise Munz [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)


    Plenoptic imaging is a promising emerging technology for single-camera, 3D diagnostics of particle fields. In this work, recent developments towards quantitative measurements of particle size, positions, and velocities are discussed. First, the technique is proven viable with measurements of the particle field generated by the impact of a water drop on a thin film of water. Next, well cont rolled experiments are used to verify diagnostic uncertainty. Finally, an example is presented of 3D plenoptic imaging of a laboratory scale, explosively generated fragment field.

  2. The HST/WFC3 Quicklook Project: A User Interface to Hubble Space Telescope Wide Field Camera 3 Data (United States)

    Bourque, Matthew; Bajaj, Varun; Bowers, Ariel; Dulude, Michael; Durbin, Meredith; Gosmeyer, Catherine; Gunning, Heather; Khandrika, Harish; Martlin, Catherine; Sunnquist, Ben; Viana, Alex


    The Hubble Space Telescope's Wide Field Camera 3 (WFC3) instrument, comprised of two detectors, UVIS (Ultraviolet-Visible) and IR (Infrared), has been acquiring ~ 50-100 images daily since its installation in 2009. The WFC3 Quicklook project provides a means for instrument analysts to store, calibrate, monitor, and interact with these data through the various Quicklook systems: (1) a ~ 175 TB filesystem, which stores the entire WFC3 archive on disk, (2) a MySQL database, which stores image header data, (3) a Python-based automation platform, which currently executes 22 unique calibration/monitoring scripts, (4) a Python-based code library, which provides system functionality such as logging, downloading tools, database connection objects, and filesystem management, and (5) a Python/Flask-based web interface to the Quicklook system. The Quicklook project has enabled large-scale WFC3 analyses and calibrations, such as the monitoring of the health and stability of the WFC3 instrument, the measurement of ~ 20 million WFC3/UVIS Point Spread Functions (PSFs), the creation of WFC3/IR persistence calibration products, and many others.

  3. A wide-field TCSPC FLIM system based on an MCP PMT with a delay-line anode. (United States)

    Becker, Wolfgang; Hirvonen, Liisa M; Milnes, James; Conneely, Thomas; Jagutzki, Ottmar; Netz, Holger; Smietana, Stefan; Suhling, Klaus


    We report on the implementation of a wide-field time-correlated single photon counting (TCSPC) method for fluorescence lifetime imaging (FLIM). It is based on a 40 mm diameter crossed delay line anode detector, where the readout is performed by three standard TCSPC boards. Excitation is performed by a picosecond diode laser with 50 MHz repetition rate. The photon arrival timing is obtained directly from the microchannel plates, with an instrumental response of ∼190 to 230 ps full width at half maximum depending on the position on the photocathode. The position of the photon event is obtained from the pulse propagation time along the two delay lines, one in x and one in y. One end of a delay line is fed into the "start" input of the corresponding TCSPC board, and the other end is delayed by 40 ns and fed into the "stop" input. The time between start and stop is directly converted into position, with a resolution of 200-250 μm. The data acquisition software builds up the distribution of the photons over their spatial coordinates, x and y, and their times after the excitation pulses, typically into 512 × 512 pixels and 1024 time channels per pixel. We apply the system to fluorescence lifetime imaging of cells labelled with Alexa 488 phalloidin in an epi-fluorescence microscope and discuss the application of our approach to other fluorescence microscopy methods.

  4. A wide-field TCSPC FLIM system based on an MCP PMT with a delay-line anode (United States)

    Becker, Wolfgang; Hirvonen, Liisa M.; Milnes, James; Conneely, Thomas; Jagutzki, Ottmar; Netz, Holger; Smietana, Stefan; Suhling, Klaus


    We report on the implementation of a wide-field time-correlated single photon counting (TCSPC) method for fluorescence lifetime imaging (FLIM). It is based on a 40 mm diameter crossed delay line anode detector, where the readout is performed by three standard TCSPC boards. Excitation is performed by a picosecond diode laser with 50 MHz repetition rate. The photon arrival timing is obtained directly from the microchannel plates, with an instrumental response of ˜190 to 230 ps full width at half maximum depending on the position on the photocathode. The position of the photon event is obtained from the pulse propagation time along the two delay lines, one in x and one in y. One end of a delay line is fed into the "start" input of the corresponding TCSPC board, and the other end is delayed by 40 ns and fed into the "stop" input. The time between start and stop is directly converted into position, with a resolution of 200-250 μm. The data acquisition software builds up the distribution of the photons over their spatial coordinates, x and y, and their times after the excitation pulses, typically into 512 × 512 pixels and 1024 time channels per pixel. We apply the system to fluorescence lifetime imaging of cells labelled with Alexa 488 phalloidin in an epi-fluorescence microscope and discuss the application of our approach to other fluorescence microscopy methods.

  5. Micrometeoroid Impacts on the Hubble Space Telescope Wide Field and Planetary Camera 2: Smaller Particle Impacts (United States)

    Ross, D. K.; Anz-Meador, P.; Liou, J.C.; Opiela, J.; Kearsley, A. T.; Grime, G.; Webb, R.; Jeynes, C.; Palitsin, V.; Colaux, J.; hide


    The radiator shield on the Wide Field and Planetary Camera 2 (WFPC2) was subject to optical inspection following return from the Hubble Space Telescope (HST) in 2009. The survey revealed over 600 impact features of > 300 micrometers diameter, from exposure in space for 16 years. Subsequently, an international collaborative programme of analysis was organized to determine the origin of hypervelocity particles responsible for the damage. Here we describe examples of the numerous smaller micrometeoroid (MM) impact features (< 700 micrometers diameter) which excavated zinc orthotitanate (ZOT) paint from the radiator surface, but did not incorporate material from underlying Al alloy; larger impacts are described by [3]. We discuss recognition and interpretation of impactor remains, and MM compositions found on WFPC2.

  6. San Pedro meeting on Wide Field Variability Surveys: Some concluding comments

    Directory of Open Access Journals (Sweden)

    Feast Michael W.


    Full Text Available This is a written version of the closing talk at the 22nd Los Alamos Stellar pulsation conference on wide field variability surveys. It comments on some of the issues which arise from the meeting. These include the need for attention to photometric standardization (especially in the infrared and the somewhat controversial problem of statistical bias in the use of parallaxes (and other methods of distance determination. Some major advances in the use of pulsating variables to study Galactic structure are mentioned. The paper includes a clarification of apparently conflicting results from classical Cepheids and RR Lyrae stars in the inner Galaxy and bulge. The importance of understanding non-periodic phenomena in variable stars, particularly asymptotic giant branch variables and R Coronae Borealis stars, is stressed, especially for its relevance to mass-loss in which pulsation may only play a minor role.

  7. Wide-window angular spectrum method for optical field propagation through ABCD systems (United States)

    Li, Yuanyang; Guo, Jin; Liu, Lisheng; Wang, Tingfeng; Shao, Junfeng


    The wide-window angular spectrum (WWAS) method is proposed to simulate field propagation through paraxial optical systems, mainly based on the Collins formula and the scaled Fourier transform (SFT). The application of the SFT algorithm makes the sampling processes in the input space, output space and spatial-frequency domains completely independent, and as a result, we can choose a larger calculation window size for simulating long-distance propagation without increasing the calculation burden. The sampling criteria are derived analytically and used in the numerical simulations to present the correctness and effectiveness of the WWAS algorithm. The advantages of the algorithm are shown by making a comparison with other angular spectrum methods for the free-space propagation case.

  8. Meteor observations with Mini-Mega-TORTORA wide-field monitoring system (United States)

    Karpov, S.; Orekhova, N.; Beskin, G.; Biryukov, A.; Bondar, S.; Ivanov, E.; Katkova, E.; Perkov, A.; Sasyuk, V.


    Here we report on the results of meteor observations with 9-channel Mini-Mega-TORTORA (MMT-9) optical monitoring system with the wide field and high temporal resolution. During the first 1.5 years of operation more than 90 thousands of meteors have been detected, at a rate of 300-350 per night, with durations from 0.1 to 2.5 seconds and angular velocities up to 38 degrees per second. The faintest detected meteors have peak brightnesses about 10 mag, while the majority have them ranging from 4 to 8 mag. Some of the meteors have been observed in BVR filters simultaneously. Color variations along the trail for them have been determined. The parameters of the detected meteors have been published online. The database also includes data from 10 thousands of meteors detected by our previous FAVOR camera during 2006-2009.

  9. Magnetic field imaging with nitrogen-vacancy ensembles

    Energy Technology Data Exchange (ETDEWEB)

    Pham, L M; Yeung, T K [School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138 (United States); Le Sage, D; Stanwix, P L; Glenn, D; Walsworth, R L [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Trifonov, A; Lukin, M D; Park, H; Yacoby, A [Physics Department, Harvard University, Cambridge, MA 02138 (United States); Cappellaro, P [Nuclear Science and Engineering Department, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Hemmer, P R, E-mail: [Electrical and Computer Engineering Department, Texas AM University, College Station, TX 77843 (United States)


    We demonstrate a method of imaging spatially varying magnetic fields using a thin layer of nitrogen-vacancy (NV) centers at the surface of a diamond chip. Fluorescence emitted by the two-dimensional NV ensemble is detected by a CCD array, from which a vector magnetic field pattern is reconstructed. As a demonstration, ac current is passed through wires placed on the diamond chip surface, and the resulting ac magnetic field patterns are imaged using an echo-based technique with sub-micron resolution over a 140 {mu}mx140 {mu}m field of view, giving single-pixel sensitivity {approx}100 nT/{radical}(Hz). We discuss ongoing efforts to further improve the sensitivity, as well as potential bioimaging applications such as real-time imaging of activity in functional, cultured networks of neurons.

  10. Precision Pointing for the Wide-Field Infrared Survey Telescope(WFIRST) (United States)

    Stoneking, Eric T.; Hsu, Oscar C.; Welter, Gary


    The Wide-Field Infrared Survey Telescope (WFIRST) mission, scheduled for a mid-2020's launch, is currently in its definition phase. The mission is designed to investigate essential questions in the areas of dark energy, exoplanets, and infrared astrophysics. WFIRST will use a 2.4-meter primary telescope (same size as the Hubble Space Telescope's primary mirror) and two instruments: the Wide Field Instrument (WFI) and the Coronagraph Instrument (CGI). In order to address the critical science requirements, the WFIRST mission will conduct large-scale surveys of the infrared sky, requiring both agility and precision pointing (11.6 milli-arcsec stability, 14 milli-arcsec jitter). This paper describes some of the challenges this mission profile presents to the Guidance, Navigation, and Control (GNC) subsystem, and some of the design elements chosen to accommodate those challenges. The high-galactic-latitude survey is characterized by 3-minute observations separated by slews ranging from 0.025 deg to 0.8 deg. The need for observation efficiency drives the slew and settle process to be as rapid as possible. A description of the shaped slew profile chosen to minimize excitation of structural oscillation, and the handoff from star tracker-gyro control to fine guidance sensor control is detailed. Also presented is the fine guidance sensor (FGS), which is integral with the primary instrument (WFI). The FGS is capable of tracking up to 18 guide stars, enabling robust FGS acquisition and precision pointing. To avoid excitation of observatory structural jitter, reaction wheel speeds are operationally maintained within set limits. In addition, the wheel balance law is designed to maintain 1-Hz separation between the wheel speeds to avoid reinforcing jitter excitation at any particular frequency. The wheel balance law and operational implications are described. Finally, the candidate GNC hardware suite needed to meet the requirements of the mission is presented.

  11. Polarimetic near-field backpropagation algorithm for application to GPR imaging of mines and minelike objects (United States)

    Morrow, Ivor L.; van Genderen, Piet


    This paper presents a novel polarimetric near-field two-dimension (2D) synthetic aperture focusing technique (SAFT) suitable for ground penetrating radar (GPR) application. The imaging algorithm is intended for locating metallic and non-metallic anti-personnel (AP's) mines using an ultra-wide-band stepped frequency radar. A radar image can be formed by coherently integrating the backscattered field over the measured frequency spectrum and cross-range scan. The coherent integration is essentially a convolution of the collected data and a focusing (test) function, which only depends on the geometry of the measurement. Wavefront curvature must be taken account of when attempting to image an object within 1-2 wavelengths off an antenna(s) phase center. Applying conventional far-field SAR imaging using a direct Fourier inversion may result in images which are increasingly blurred and shifted at points more distant from the point of rotation of the focusing function. Here, a focusing function is first derived based on a conventional far-field geometrical optic propagator for a two-media problem. Then to correct for geometric distortion in the focusing function when applied in the near-field zone we introduce higher order terms to the range function. In order to verify and augment the technique described two field studies were conducted, over different frequency spectrums, the finding of which demonstrates the utility of the technique and the experimental practices.

  12. Novel compact photoacoustic imaging system to explore the applications in the medical imaging field (United States)

    Irisawa, Kaku; Wada, Takatsugu; Hayakawa, Toshiro; Ishihara, Miya


    PhotoAcoustic (PA) imaging is a promising imaging method using the pulsed-laser light source and ultrasound detector. PA image shows the features of optical contrast in biological tissue with ultrasound-like depth and resolution. In the human body, Hemoglobin of the blood is strong optical absorber, so the high-contrast blood distribution (vascular) image is obtained by PA imaging. Recently, FUJIFILM has developed the PA imaging system to explore its application in medical imaging field. In this system, the fusion of PA and conventional ultrasound image is realized, for example, ultrasound Doppler image is superposed to the PA and B-mode image. The system features and some results of clinical studies will be introduced.

  13. Note: Grazing incidence small and wide angle x-ray scattering combined with imaging ellipsometry

    Energy Technology Data Exchange (ETDEWEB)

    Koerstgens, V.; Meier, R.; Ruderer, M. A.; Guo, S.; Chiang, H.-Y.; Mueller-Buschbaum, P. [Technische Universitaet Muenchen, Physik-Department, Lehrstuhl fuer Funktionelle Materialien, James-Franck-Str. 1, 85748 Garching (Germany); Perlich, J.; Roth, S. V.; Gehrke, R. [HASYLAB, DESY, Notkestr. 85, 22607, Hamburg (Germany)


    The combination of grazing incidence small angle x-ray scattering (GISAXS) and grazing incidence wide angle x-ray scattering (GIWAXS) with optical imaging ellipsometry is presented as an upgrade of the available measurement techniques at the wiggler beamline BW4 of the Hamburger Synchrotronstrahlungslabor. The instrument is introduced with the description of the alignment procedure to assure the measurement of imaging ellipsometry and GISAXS/GIWAXS on the same sample spot. To demonstrate the possibilities of the new instrument examples of morphological investigation on films made of poly(3-hexylthiophene) and [6,6]-phenyl-C{sub 61} butyric acid methyl ester as well as textured poly(9,9-dioctylfluorene-alt-benzo-thia-diazole) are shown.

  14. Handheld and mobile hyperspectral imaging sensors for wide-area standoff detection of explosives and chemical warfare agents (United States)

    Gomer, Nathaniel R.; Gardner, Charles W.; Nelson, Matthew P.


    Hyperspectral imaging (HSI) is a valuable tool for the investigation and analysis of targets in complex background with a high degree of autonomy. HSI is beneficial for the detection of threat materials on environmental surfaces, where the concentration of the target of interest is often very low and is typically found within complex scenery. Two HSI techniques that have proven to be valuable are Raman and shortwave infrared (SWIR) HSI. Unfortunately, current generation HSI systems have numerous size, weight, and power (SWaP) limitations that make their potential integration onto a handheld or field portable platform difficult. The systems that are field-portable do so by sacrificing system performance, typically by providing an inefficient area search rate, requiring close proximity to the target for screening, and/or eliminating the potential to conduct real-time measurements. To address these shortcomings, ChemImage Sensor Systems (CISS) is developing a variety of wide-field hyperspectral imaging systems. Raman HSI sensors are being developed to overcome two obstacles present in standard Raman detection systems: slow area search rate (due to small laser spot sizes) and lack of eye-safety. SWIR HSI sensors have been integrated into mobile, robot based platforms and handheld variants for the detection of explosives and chemical warfare agents (CWAs). In addition, the fusion of these two technologies into a single system has shown the feasibility of using both techniques concurrently to provide higher probability of detection and lower false alarm rates. This paper will provide background on Raman and SWIR HSI, discuss the applications for these techniques, and provide an overview of novel CISS HSI sensors focused on sensor design and detection results.

  15. Mapping of summer sea ice in the Chukchi Sea using KOMPSAT-5 wide swath SAR images (United States)

    Han, H.; Kim, H. C.


    Synthetic Aperture Radar (SAR) has been widely used for mapping sea ice because it can observe Earth's surface regardless of sun altitudes and weather conditions. Korea Multi-Purpose SATellte-5 (KOMPSAT-5) is South Korea's first satellite equipped with X-band SAR system that provides high-resolution images in various observation modes. In this study, sea ice mapping model based on Random Forest (RF), a rule-based machine learning approach, was developed for KOMPSAT-5 Enhanced Wide (EW) swath SAR data obtained from August to September 2015 in the Chukchi Sea of the Arctic Ocean. All SAR images were acquired in HH-polarization at incidence angle ranging from 17 to 50°. Each SAR image covers the area of 100 km × 100 km. A total of 12 texture features derived from backscattering intensity and grey level co-occurrence matrix (GLCM) were used as input variables for sea ice mapping model. The sea ice mapping model based on the RF produced sea ice map with a grid size of 125 m, with the overall accuracy of 99.2% and the kappa coefficient of 98.5% in the classification of sea ice and open water. Sea ice concentration (SIC) was computed from the RF-derived sea ice maps and compared with that from the observations of two passive microwave sensors— the Special Sensor Microwave Imager/Sounder (SSMIS) and the Advanced Microwave Scanning Radiometer 2 (AMSR2). SSMIS and AMSR2 estimates SIC using the NASA Team (NT) and Turbulence Interaction STudy (ARTIST) Sea Ice (ASI) algorithm, respectively. The SSMIS NT SIC was underestimated in marginal ice zone and compact ice zone, while they were overestimated in sea ice edge. Meanwhile, the AMSR2 ASI SIC was underestimated in compact ice zone and overestimated in other regions. This research was funded by the Korea Polar Research Institute (KOPRI) under the project titled `SaTellite remote sensing on west Antarctic ocean Research (STAR) (PE16040)'.


    Energy Technology Data Exchange (ETDEWEB)

    Lu, Ning; Makarov, Yuri V.; Weimar, Mark R.; Rudolph, Frank; Murthy, Shashikala; Arseneaux, Jim; Loutan, Clyde; Chowdhury, S.


    This research was conducted by Pacific Northwest National Laboratory (PNNL) operated for the U.S. department of Energy (DOE) by Battelle Memorial Institute for Bonneville Power Administration (BPA), California Institute for Energy and Environment (CIEE) and California Energy Commission (CEC). A wide-area energy management system (WAEMS) is a centralized control system that operates energy storage devices (ESDs) located in different places to provide energy and ancillary services that can be shared among balancing authorities (BAs). The goal of this research is to conduct flywheel field tests, investigate the technical characteristics and economics of combined hydro-flywheel regulation services that can be shared between Bonneville Power Administration (BPA) and California Independent System Operator (CAISO) controlled areas. This report is the second interim technical report for Phase II of the WAEMS project. This report presents: 1) the methodology of sharing regulation service between balancing authorities, 2) the algorithm to allocate the regulation signal between the flywheel and hydro power plant to minimize the wear-and-tear of the hydro power plants, 3) field results of the hydro-flywheel regulation service (conducted by the Beacon Power), and 4) the performance metrics and economic analysis of the combined hydro-flywheel regulation service.

  17. Multi-feature combined cloud and cloud shadow detection in GaoFen-1 wide field of view imagery (United States)

    Li, Zhiwei; Shen, Huanfeng; Li, Huifang; Xia, Guisong; Gamba, Paolo; Zhang, Liangpei


    The wide field of view (WFV) imaging system onboard the Chinese GaoFen-1 (GF-1) optical satellite has a 16-m resolution and four-day revisit cycle for large-scale Earth observation. The advantages of the high temporal-spatial resolution and the wide field of view make the GF-1 WFV imagery very popular. However, cloud cover is an inevitable problem in GF-1 WFV imagery, which influences its precise application. Accurate cloud and cloud shadow detection in GF-1 WFV imagery is quite difficult due to the fact that there are only three visible bands and one near-infrared band. In this paper, an automatic multi-feature combined (MFC) method is proposed for cloud and cloud shadow detection in GF-1 WFV imagery. The MFC algorithm first implements threshold segmentation based on the spectral features and mask refinement based on guided filtering to generate a preliminary cloud mask. The geometric features are then used in combination with the texture features to improve the cloud detection results and produce the final cloud mask. Finally, the cloud shadow mask can be acquired by means of the cloud and shadow matching and follow-up correction process. The method was validated using 108 globally distributed scenes. The results indicate that MFC performs well under most conditions, and the average overall accuracy of MFC cloud detection is as high as 96.8%. In the contrastive analysis with the official provided cloud fractions, MFC shows a significant improvement in cloud fraction estimation, and achieves a high accuracy for the cloud and cloud shadow detection in the GF-1 WFV imagery with fewer spectral bands. The proposed method could be used as a preprocessing step in the future to monitor land-cover change, and it could also be easily extended to other optical satellite imagery which has a similar spectral setting.

  18. Prime Focus Spectrograph: A very wide-field, massively multiplexed, optical & near-infrared spectrograph for Subaru Telescope (United States)

    Tamura, Naoyuki

    This short article is about Prime Focus Spectrograph (PFS), a very wide-field, massively-multiplexed, and optical & near-infrared (NIR) spectrograph as a next generation facility instrument on Subaru Telescope. More details and updates are available on the PFS official website (, blog (, and references therein. The project, instrument, & timeline PFS will position 2400 fibers to science targets or blank sky in the 1.3 degree field on the Subaru prime focus. These fibers will be quickly (~60sec) reconfigurable and feed the photons during exposures to the Spectrograph System (SpS). SpS consists of 4 modules each of which accommodate ~600 fibers and deliver spectral images ranging from 380nm to 1260nm simultaneously at one exposure via the 3 arms of blue, red, and NIR cameras. The instrument development has been undertaken by the international collaboration at the initiative of Kavli IPMU. The project is now going into the construction phase aiming at system integration and on-sky engineering observations in 2017-2018, and science operation in 2019. The survey design has also been under development envisioning a survey spanning ~300 nights over ~5 years in the framework of Subaru Strategic Program (SSP). The key science areas are: Cosmology, galaxy/AGN evolution, and Galactic Archaeology (GA) (Takada et al. 2014). The cosmology program will be to constrain the nature of dark energy via a survey of emission line galaxies over a comoving volume of 10 Gpc3 at z=0.8-2.4. In the galaxy/AGN program, the wide wavelength coverage of PFS as well as the large field of view will be exploited to characterize the galaxy populations and its clustering properties over a wide redshift range. A survey of color-selected galaxies/AGN at z = 1-2 will be conducted over 20 square degrees yielding a fair sample of galaxies with stellar masses down to ~1010 M ⊙. In the GA program, radial velocities and chemical abundances of stars in the Milky

  19. SAAO's new robotic telescope and WiNCam (Wide-field Nasmyth Camera) (United States)

    Worters, Hannah L.; O'Connor, James E.; Carter, David B.; Loubser, Egan; Fourie, Pieter A.; Sickafoose, Amanda; Swanevelder, Pieter


    The South African Astronomical Observatory (SAAO) is designing and manufacturing a wide-field camera for use on two of its telescopes. The initial concept was of a Prime focus camera for the 74" telescope, an equatorial design made by Grubb Parsons, where it would employ a 61mmx61mm detector to cover a 23 arcmin diameter field of view. However, while in the design phase, SAAO embarked on the process of acquiring a bespoke 1-metre robotic alt-az telescope with a 43 arcmin field of view, which needs a homegrown instrument suite. The Prime focus camera design was thus adapted for use on either telescope, increasing the detector size to 92mmx92mm. Since the camera will be mounted on the Nasmyth port of the new telescope, it was dubbed WiNCam (Wide-field Nasmyth Camera). This paper describes both WiNCam and the new telescope. Producing an instrument that can be swapped between two very different telescopes poses some unique challenges. At the Nasmyth port of the alt-az telescope there is ample circumferential space, while on the 74 inch the available envelope is constrained by the optical footprint of the secondary, if further obscuration is to be avoided. This forces the design into a cylindrical volume of 600mm diameter x 250mm height. The back focal distance is tightly constrained on the new telescope, shoehorning the shutter, filter unit, guider mechanism, a 10mm thick window and a tip/tilt mechanism for the detector into 100mm depth. The iris shutter and filter wheel planned for prime focus could no longer be accommodated. Instead, a compact shutter with a thickness of less than 20mm has been designed in-house, using a sliding curtain mechanism to cover an aperture of 125mmx125mm, while the filter wheel has been replaced with 2 peripheral filter cartridges (6 filters each) and a gripper to move a filter into the beam. We intend using through-vacuum wall PCB technology across the cryostat vacuum interface, instead of traditional hermetic connector-based wiring. This

  20. Hyper Suprime-Camera Survey of the Akari NEP Wide Field (United States)

    Goto, Tomotsugu; Toba, Yoshiki; Utsumi, Yousuke; Oi, Nagisa; Takagi, Toshinobu; Malkan, Matt; Ohayma, Youichi; Murata, Kazumi; Price, Paul; Karouzos, Marios; Matsuhara, Hideo; Nakagawa, Takao; Wada, Takehiko; Serjeant, Steve; Burgarella, Denis; Buat, Veronique; Takada, Masahiro; Miyazaki, Satoshi; Oguri, Masamune; Miyaji, Takamitsu; Oyabu, Shinki; White, Glenn; Takeuchi, Tsutomu; Inami, Hanae; Perason, Chris; Malek, Katarzyna; Marchetti, Lucia; Lee, Hyung Mok; Im, Myung; Kim, Seong Jin; Koptelova, Ekaterina; Chao, Dani; Wu, Yi-Han; AKARI NEP Survey Team; AKARI All Sky Survey Team


    The extragalactic background suggests half the energy generated by stars was reprocessed into the infrared (IR) by dust. At z ∼1.3, 90% of star formation is obscured by dust. To fully understand the cosmic star formation history, it is critical to investigate infrared emission. AKARI has made deep mid-IR observation using its continuous 9-band filters in the NEP field (5.4 deg^2), using ∼10% of the entire pointed observations available throughout its lifetime. However, there remain 11,000 AKARI infrared sources undetected with the previous CFHT/Megacam imaging (r ∼25.9ABmag). Redshift and IR luminosity of these sources are unknown. These sources may contribute significantly to the cosmic star-formation rate density (CSFRD). For example, if they all lie at 1 Camera (HSC), which has 1.5 deg field of view in diameter on Subaru 8m telescope. This will provide photometric redshift information, and thereby IR luminosity for the previously-undetected 11,000 faint AKARI IR sources. Combined with AKARI's mid-IR AGN/SF diagnosis, and accurate mid-IR luminosity measurement, this will allow a complete census of cosmic star-formation/AGN accretion history obscured by dust.

  1. Direct Neural Imaging using Ultra-Low Field Magnetic Resonance (United States)

    Maskaly, Karlene; Espy, Michelle; Flynn, Mark; Gomez, John; Kraus, Robert; Matlashov, Andrei; Mosher, John; Newman, Shaun; Owens, Tuba; Peters, Mark; Sandin, J.; Schultz, Larry; Urbaitis, Algis; Volegov, Petr; Zotev, Vadim


    An enduring challenge in neuroscience is the accurate in vivo mapping of neural activity with high spatial and temporal resolution. A method being developed by our group tries to meet this challenge by using Ultra-Low Field (ULF) MRI. Other groups have attempted direct neural imaging (DNI) using high field MRI. However, the use of ULF presents two advantages. First, the susceptibility artifact at high fields, which masks the DNI signal, is negligible at low fields. Second, the reduced Larmor frequency at ULF may overlap with the frequency spectrum of the neural magnetic field, resonantly enhancing the MRI signal. In this presentation, I will first show our custom-built ULF MRI setups that have successfully produced ULF anatomical images. I will then highlight the numerous studies we have done to investigate the feasibility of DNI with these systems, including both experimental and theoretical studies.

  2. A Very Low Dark Current Temperature-Resistant, Wide Dynamic Range, Complementary Metal Oxide Semiconductor Image Sensor (United States)

    Mizobuchi, Koichi; Adachi, Satoru; Tejada, Jose; Oshikubo, Hiromichi; Akahane, Nana; Sugawa, Shigetoshi


    A very low dark current (VLDC) temperature-resistant approach which best suits a wide dynamic range (WDR) complementary metal oxide semiconductor (CMOS) image sensor with a lateral over-flow integration capacitor (LOFIC) has been developed. By implementing a low electric field photodiode without a trade-off of full well-capacity, reduced plasma damage, re-crystallization, and termination of silicon-silicon dioxide interface states in the front end of line and back end of line (FEOL and BEOL) in a 0.18 µm, two polycrystalline silicon, three metal (2P3M) process, the dark current is reduced to 11 e-/s/pixel (0.35 e-/s/µm2: pixel area normalized) at 60 °C, which is the lowest value ever reported. For further robustness at low and high temperatures, 1/3-in., 5.6-µm pitch, 800×600 pixel sensor chips with low noise readout circuits designed for a signal and noise hold circuit and a programmable gain amplifier (PGA) have also been deposited with an inorganic cap layer on a micro-lens and covered with a metal hermetically sealed package assembly. Image sensing performance results in 2.4 e-rms temporal noise and 100 dB dynamic range (DR) with 237 ke- full well-capacity. The operating temperature range is extended from -40 to 85 °C while retaining good image quality.

  3. Estimation of Dense Image Flow Fields in Fluids

    DEFF Research Database (Denmark)

    Larsen, Rasmus; Conradsen, Knut; Ersbøll, Bjarne Kjær

    of the local energy distribution, which is sampled using a set of 3-D spatio-temporal filters. The estimated local energy distribution also allows us to compute a certainty measure of the estimated local flow. The algorithm furhtermore utilizes Markovian random fields in order to incorporate smoothness across......The estimation of flow fields from time sequences of satellite imagery has a number of important applications. For visualization of cloud or sea ice movements in sequences of crude temporal sampling a satisfactory non blurred temporal interpolation can be performed only when the flow field...... the field. To obtain smothness we will constrain first as well as second order derivatives of the flow field. The performance of the algorithm is illustrated by the estimation of the flow fields corresponding to a sequence of Meteosat thermal images. The estimated flow fields are used in a temporal...

  4. New Approach for Unambiguous High-Resolution Wide-Swath SAR Imaging

    Directory of Open Access Journals (Sweden)

    Yueguan Lin


    Full Text Available The high-resolution wide-swath (HRWS SAR system uses a small antenna for transmitting waveform and multiple antennas both in elevation and azimuth for receiving echoes. It has the potential to achieve wide spatial coverage and fine azimuth resolution, while it suffers from elevation pattern loss caused by the presence of topographic height and impaired azimuth resolution caused by nonuniform sampling. A new approach for HRWS SAR imaging based on compressed sensing (CS is introduced. The data after range compression of multiple elevation apertures are used to estimate direction of arrival (DOA of targets via CS, and the adaptive digital beamforming in elevation is achieved accordingly, which avoids the pattern loss of scan-on-receive (SCORE algorithm when topographic height exists. The effective phase centers of the system are nonuniformly distributed when displaced phase center antenna (DPCA technology is adopted, which causes Doppler ambiguities under traditional SAR imaging algorithms. Azimuth reconstruction based on CS can resolve this problem via precisely modeling the nonuniform sampling. Validation with simulations and experiment in an anechoic chamber are presented.

  5. Magnetic resonance imaging with nonlinear gradient fields signal encoding and image reconstruction

    CERN Document Server

    Schultz, Gerrit


    Within the past few decades magnetic resonance imaging has become one of the most important imaging modalities in medicine. For a reliable diagnosis of pathologies further technological improvements are of primary importance. This text deals with a radically new approach of image encoding: The fundamental principle of gradient linearity is challenged by investigating the possibilities of acquiring anatomical images with the help of nonlinear gradient fields. Besides a thorough theoretical analysis with a focus on signal encoding and image reconstruction, initial hardware implementations are tested using phantom as well as in-vivo measurements. Several applications are presented that give an impression about the implications that this technological advancement may have for future medical diagnostics.   Contents n  Image Reconstruction in MRI n  Nonlinear Gradient Encoding: PatLoc Imaging n  Presentation of Initial Hardware Designs n  Basics of Signal Encoding and Image Reconstruction in PatLoc Imaging n ...

  6. Searching for fast optical transients by means of a wide-field monitoring observations with high temporal resolution (United States)

    Beskin, G.; Karpov, S.; Plokhotnichenko, V.; Bondar, S.; Ivanov, E.; Perkov, A.; Greco, G.; Guarnieri, A.; Bartolini, C.

    We discuss the strategy of search for fast optical transients accompanying gamma-ray bursts by means of continuous monitoring of wide sky fields with high temporal resolution. We describe the design, performance and results of our cameras, FAVOR and TORTORA. Also we discuss the perspectives of this strategy and possible design of next-generation equipment for wide-field monitoring which will be able to detect optical transients and to study their color and polarization properties with high time resolution.

  7. Electric Potential and Electric Field Imaging with Applications (United States)

    Generazio, Ed


    The technology and techniques for remote quantitative imaging of electrostatic potentials and electrostatic fields in and around objects and in free space is presented. Electric field imaging (EFI) technology may be applied to characterize intrinsic or existing electric potentials and electric fields, or an externally generated electrostatic field may be used for (illuminating) volumes to be inspected with EFI. The baseline sensor technology, electric field sensor (e-sensor), and its construction, optional electric field generation (quasistatic generator), and current e-sensor enhancements (ephemeral e-sensor) are discussed. Demonstrations for structural, electronic, human, and memory applications are shown. This new EFI capability is demonstrated to reveal characterization of electric charge distribution, creating a new field of study that embraces areas of interest including electrostatic discharge mitigation, crime scene forensics, design and materials selection for advanced sensors, dielectric morphology of structures, inspection of containers, inspection for hidden objects, tether integrity, organic molecular memory, and medical diagnostic and treatment efficacy applications such as cardiac polarization wave propagation and electromyography imaging.

  8. Anisoplanatic error evaluation and wide-field adaptive optics performance at Dome C, Antarctica (United States)

    Carbillet, M.; Aristidi, É.; Giordano, C.; Vernin, J.


    The aim of this paper is twofold: (i) to deduce the most representative C_N^2 profile(s) for Dome C (DC), Antarctica, from the latest measurements, and (ii) to evaluate the performance of a wide-field adaptive optics (AO) system equipping a 2-3 m telescope. Two models of the C_N^2 profile, corresponding to the bimodal distribution of seeing (a poor seeing mode and a good seeing mode), are composed from both Single Star Scidar data and balloon radio soundings. The anisoplanatic error is first evaluated for a standard AO system from Monte Carlo simulations. DC is shown to outperform Mauna Kea for both seeing modes. A simple ground-layer AO (GLAO) system is then considered. This provides an anisoplanatic error of less than 150 nm over a field of 30 arcmin for the good seeing mode, corresponding to a basic performance Strehl ratio (considering also the fitting and the servo-lag errors) of more than ˜80 per cent in K and ˜50 per cent in J. The poor seeing model shows performance comparable to the Mauna Kea model. We also studied the influence of telescope elevation, showing that a telescope at 40 m would perform, in the poor seeing mode, like a telescope observing 8 m above the ground in the good seeing mode. Finally, we show that while tip-tilt-only correction permits high levels of correction in the good seeing mode at 40 m, it is not as efficient as the GLAO system, even at an altitude of 8 m, and it is not sufficient for high levels of correction for poor seeing, even at a height of 40 m.

  9. Medical Imaging Field of Magnetic Resonance Imaging: Identification of Specialties within the Field (United States)

    Grey, Michael L.


    This study was conducted to determine if specialty areas are emerging in the magnetic resonance imaging (MRI) profession due to advancements made in the medical sciences, imaging technology, and clinical applications used in MRI that would require new developments in education/training programs and national registry examinations. In this…

  10. Magnetic resonance imaging without field cycling at less than earth's magnetic field (United States)

    Lee, Seong-Joo; Shim, Jeong Hyun; Kim, Kiwoong; Yu, Kwon Kyu; Hwang, Seong-min


    A strong pre-polarization field, usually tenths of a milli-tesla in magnitude, is used to increase the signal-to-noise ratio in ordinary superconducting quantum interference device-based nuclear magnetic resonance/magnetic resonance imaging experiments. Here, we introduce an experimental approach using two techniques to remove the need for the pre-polarization field. A dynamic nuclear polarization (DNP) technique enables us to measure an enhanced resonance signal. In combination with a π / 2 pulse to avoid the Bloch-Siegert effect in a micro-tesla field, we obtained an enhanced magnetic resonance image by using DNP technique with a 34.5 μT static external magnetic field without field cycling. In this approach, the problems of eddy current and flux trapping in the superconducting pickup coil, both due to the strong pre-polarization field, become negligible.

  11. Magnetic resonance imaging without field cycling at less than earth's magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seong-Joo, E-mail:; Shim, Jeong Hyun; Kim, Kiwoong; Yu, Kwon Kyu; Hwang, Seong-min [Center for Biosignals, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon 305-340 (Korea, Republic of)


    A strong pre-polarization field, usually tenths of a milli-tesla in magnitude, is used to increase the signal-to-noise ratio in ordinary superconducting quantum interference device-based nuclear magnetic resonance/magnetic resonance imaging experiments. Here, we introduce an experimental approach using two techniques to remove the need for the pre-polarization field. A dynamic nuclear polarization (DNP) technique enables us to measure an enhanced resonance signal. In combination with a π/2 pulse to avoid the Bloch-Siegert effect in a micro-tesla field, we obtained an enhanced magnetic resonance image by using DNP technique with a 34.5 μT static external magnetic field without field cycling. In this approach, the problems of eddy current and flux trapping in the superconducting pickup coil, both due to the strong pre-polarization field, become negligible.

  12. The neutron imaging system fielded at the National Ignition Facility

    Directory of Open Access Journals (Sweden)

    Fittinghoff D.N.


    Full Text Available We have fielded a neutron imaging system at the National Ignition Facility to collect images of fusion neutrons produced in the implosion of inertial confinement fusion experiments and scattered neutrons from (n, n′ reactions of the source neutrons in the surrounding dense material. A description of the neutron imaging system is presented, including the pinhole array aperture, the line-of-sight collimation, the scintillator-based detection system and the alignment systems and methods. Discussion of the alignment and resolution of the system is presented. We also discuss future improvements to the system hardware.

  13. The Neutron Imaging System Fielded at the National Ignition Facility

    Energy Technology Data Exchange (ETDEWEB)

    Fittinghoff, D N; Atkinson, D P; Bower, D E; Drury, O B; Dzenitis, J M; Felker, B; Frank, M; Liddick, S N; Moran, M J; Roberson, G P; Weiss, P B; Grim, G P; Aragonez, R J; Archuleta, T N; Batha, S H; Clark, D D; Clark, D J; Danly, C R; Day, R D; Fatherley, V E; Finch, J P; Garcia, F P; Gallegos, R A; Guler, N; Hsu, A H; Jaramillo, S A; Loomis, E N; Mares, D; Martinson, D D; Merrill, F E; Morgan, G L; Munson, C; Murphy, T J; Oertel, J A; Polk, P J; Schmidt, D W; Tregillis, I L; Valdez, A C; Volegov, P L; Wang, T F; Wilde, C H; Wilke, M D; Wilson, D C; Buckles, R A; Cradick, J R; Kaufman, M I; Lutz, S S; Malone, R M; Traille, A


    We have fielded a neutron imaging system at the National Ignition Facility to collect images of fusion neutrons produced in the implosion of inertial confinement fusion experiments and scattered neutrons from (n, n') reactions of the source neutrons in the surrounding dense material. A description of the neutron imaging system will be presented, including the pinhole array aperture, the line-of-sight collimation, the scintillator-based detection system and the alignment systems and methods. Discussion of the alignment and resolution of the system will be presented. We will also discuss future improvements to the system hardware.

  14. Ultra-fast bright field and fluorescence imaging of the dynamics of micrometer-sized objects (United States)

    Chen, Xucai; Wang, Jianjun; Versluis, Michel; de Jong, Nico; Villanueva, Flordeliza S.


    High speed imaging has application in a wide area of industry and scientific research. In medical research, high speed imaging has the potential to reveal insight into mechanisms of action of various therapeutic interventions. Examples include ultrasound assisted thrombolysis, drug delivery, and gene therapy. Visual observation of the ultrasound, microbubble, and biological cell interaction may help the understanding of the dynamic behavior of microbubbles and may eventually lead to better design of such delivery systems. We present the development of a high speed bright field and fluorescence imaging system that incorporates external mechanical waves such as ultrasound. Through collaborative design and contract manufacturing, a high speed imaging system has been successfully developed at the University of Pittsburgh Medical Center. We named the system "UPMC Cam," to refer to the integrated imaging system that includes the multi-frame camera and its unique software control, the customized modular microscope, the customized laser delivery system, its auxiliary ultrasound generator, and the combined ultrasound and optical imaging chamber for in vitro and in vivo observations. This system is capable of imaging microscopic bright field and fluorescence movies at 25 × 106 frames per second for 128 frames, with a frame size of 920 × 616 pixels. Example images of microbubble under ultrasound are shown to demonstrate the potential application of the system.

  15. Functional imaging reveals numerous fields in the monkey auditory cortex.

    Directory of Open Access Journals (Sweden)

    Christopher I Petkov


    Full Text Available Anatomical studies propose that the primate auditory cortex contains more fields than have actually been functionally confirmed or described. Spatially resolved functional magnetic resonance imaging (fMRI with carefully designed acoustical stimulation could be ideally suited to extend our understanding of the processing within these fields. However, after numerous experiments in humans, many auditory fields remain poorly characterized. Imaging the macaque monkey is of particular interest as these species have a richer set of anatomical and neurophysiological data to clarify the source of the imaged activity. We functionally mapped the auditory cortex of behaving and of anesthetized macaque monkeys with high resolution fMRI. By optimizing our imaging and stimulation procedures, we obtained robust activity throughout auditory cortex using tonal and band-passed noise sounds. Then, by varying the frequency content of the sounds, spatially specific activity patterns were observed over this region. As a result, the activity patterns could be assigned to many auditory cortical fields, including those whose functional properties were previously undescribed. The results provide an extensive functional tessellation of the macaque auditory cortex and suggest that 11 fields contain neurons tuned for the frequency of sounds. This study provides functional support for a model where three fields in primary auditory cortex are surrounded by eight neighboring "belt" fields in non-primary auditory cortex. The findings can now guide neurophysiological recordings in the monkey to expand our understanding of the processing within these fields. Additionally, this work will improve fMRI investigations of the human auditory cortex.

  16. Incorporating biological pathways via a Markov random field model in genome-wide association studies.

    Directory of Open Access Journals (Sweden)

    Min Chen


    Full Text Available Genome-wide association studies (GWAS examine a large number of markers across the genome to identify associations between genetic variants and disease. Most published studies examine only single markers, which may be less informative than considering multiple markers and multiple genes jointly because genes may interact with each other to affect disease risk. Much knowledge has been accumulated in the literature on biological pathways and interactions. It is conceivable that appropriate incorporation of such prior knowledge may improve the likelihood of making genuine discoveries. Although a number of methods have been developed recently to prioritize genes using prior biological knowledge, such as pathways, most methods treat genes in a specific pathway as an exchangeable set without considering the topological structure of a pathway. However, how genes are related with each other in a pathway may be very informative to identify association signals. To make use of the connectivity information among genes in a pathway in GWAS analysis, we propose a Markov Random Field (MRF model to incorporate pathway topology for association analysis. We show that the conditional distribution of our MRF model takes on a simple logistic regression form, and we propose an iterated conditional modes algorithm as well as a decision theoretic approach for statistical inference of each gene's association with disease. Simulation studies show that our proposed framework is more effective to identify genes associated with disease than a single gene-based method. We also illustrate the usefulness of our approach through its applications to a real data example.

  17. Application of a wide-field electromagnetic method to shale gas exploration in South China (United States)

    Yang, Xue-Li; Li, Bo; Peng, Chuan-Sheng; Yang, Yang


    In an effort to reduce the shale gas exploration risks and costs, we applied the wide-field electromagnetic method (WFEM), because of its strong anti-interference capability, high resolution, ability to conduct exploration at large depths, and high efficiency, to the Bayan Syncline in the South Huayuan block, Hunan Province. We collected rock samples and analyzed their resistivity and induced polarization (IP) and built A series of two-dimensional models for geological conditions to investigate the applicability of WFEM to different geological structures. We also analyzed the correlation between TOC of shale and the resistivity and IP ratio to determine the threshold for identifying target formations. We used WFEM to identify the underground structures and determine the distribution, depth, and thickness of the target strata. Resistivity, IP, and total organic carbon were used to evaluate the shale gas prospects and select favorable areas (sweet spots) for exploration and development. Subsequently, drilling in these areas proved the applicability of WFEM in shale gas exploration.

  18. High performance ring oscillators from 10-nm wide silicon nanowire field-effect transistors

    KAUST Repository

    Huang, Ruo-Gu


    We explore 10-nm wide Si nanowire (SiNW) field-effect transistors (FETs) for logic applications, via the fabrication and testing of SiNW-based ring oscillators. We report on SiNW surface treatments and dielectric annealing, for producing SiNW FETs that exhibit high performance in terms of large on/off-state current ratio (~108), low drain-induced barrier lowering (~30 mV) and low subthreshold swing (~80 mV/decade). The performance of inverter and ring-oscillator circuits fabricated from these nanowire FETs are also explored. The inverter demonstrates the highest voltage gain (~148) reported for a SiNW-based NOT gate, and the ring oscillator exhibits near rail-to-rail oscillation centered at 13.4 MHz. The static and dynamic characteristics of these NW devices indicate that these SiNW-based FET circuits are excellent candidates for various high-performance nanoelectronic applications. © 2011 Tsinghua University Press and Springer-Verlag Berlin Heidelberg.


    Energy Technology Data Exchange (ETDEWEB)

    Atkinson, Adam M.; Abraham, Roberto G. [Department of Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, ON M5S 3H4 (Canada); Ferguson, Annette M. N. [Institute for Astronomy, University of Edinburgh, Blackford Hill, Edinburgh EH9 3HJ (United Kingdom)


    We present an analysis of the detectability of faint tidal features in galaxies from the wide-field component of the Canada-France-Hawaii Telescope Legacy Survey. Our sample consists of 1781 luminous (M{sub r{sup '}}<-19.3 mag) galaxies in the magnitude range 15.5 mag < r' < 17 mag and in the redshift range 0.04 < z < 0.2. Although we have classified tidal features according to their morphology (e.g., streams, shells, and tails), we do not attempt to interpret them in terms of their physical origin (e.g., major versus minor merger debris). Instead, we provide a catalog that is intended to provide raw material for future investigations which will probe the nature of low surface brightness substructure around galaxies. We find that around 12% of the galaxies in our sample show clear tidal features at the highest confidence level. This fraction rises to about 18% if we include systems with convincing, albeit weaker tidal features, and to 26% if we include systems with more marginal features that may or may not be tidal in origin. These proportions are a strong function of rest-frame color and of stellar mass. Linear features, shells, and fans are much more likely to occur in massive galaxies with stellar masses >10{sup 10.5} M {sub Sun }, and red galaxies are twice as likely to show tidal features than are blue galaxies.

  20. On the pinned field image binarization for signature generation in image ownership verification method

    Directory of Open Access Journals (Sweden)

    Chang Hsuan


    Full Text Available Abstract The issue of pinned field image binarization for signature generation in the ownership verification of the protected image is investigated. The pinned field explores the texture information of the protected image and can be employed to enhance the watermark robustness. In the proposed method, four optimization schemes are utilized to determine the threshold values for transforming the pinned field into a binary feature image, which is then utilized to generate an effective signature image. Experimental results show that the utilization of optimization schemes can significantly improve the signature robustness from the previous method (Lee and Chang, Opt. Eng. 49 (9, 097005, 2010. While considering both the watermark retrieval rate and the computation speed, the genetic algorithm is strongly recommended. In addition, compared with Chang and Lin's scheme (J. Syst. Softw. 81 (7, 1118-1129, 2008, the proposed scheme also has better performance.

  1. Weighted bi-prediction for light field image coding (United States)

    Conti, Caroline; Nunes, Paulo; Ducla Soares, Luís.


    Light field imaging based on a single-tier camera equipped with a microlens array - also known as integral, holoscopic, and plenoptic imaging - has currently risen up as a practical and prospective approach for future visual applications and services. However, successfully deploying actual light field imaging applications and services will require developing adequate coding solutions to efficiently handle the massive amount of data involved in these systems. In this context, self-similarity compensated prediction is a non-local spatial prediction scheme based on block matching that has been shown to achieve high efficiency for light field image coding based on the High Efficiency Video Coding (HEVC) standard. As previously shown by the authors, this is possible by simply averaging two predictor blocks that are jointly estimated from a causal search window in the current frame itself, referred to as self-similarity bi-prediction. However, theoretical analyses for motion compensated bi-prediction have suggested that it is still possible to achieve further rate-distortion performance improvements by adaptively estimating the weighting coefficients of the two predictor blocks. Therefore, this paper presents a comprehensive study of the rate-distortion performance for HEVC-based light field image coding when using different sets of weighting coefficients for self-similarity bi-prediction. Experimental results demonstrate that it is possible to extend the previous theoretical conclusions to light field image coding and show that the proposed adaptive weighting coefficient selection leads to up to 5 % of bit savings compared to the previous self-similarity bi-prediction scheme.

  2. Electric Potential and Electric Field Imaging with Dynamic Applications & Extensions (United States)

    Generazio, Ed


    The technology and methods for remote quantitative imaging of electrostatic potentials and electrostatic fields in and around objects and in free space is presented. Electric field imaging (EFI) technology may be applied to characterize intrinsic or existing electric potentials and electric fields, or an externally generated electrostatic field made be used for volumes to be inspected with EFI. The baseline sensor technology (e-Sensor) and its construction, optional electric field generation (quasi-static generator), and current e- Sensor enhancements (ephemeral e-Sensor) are discussed. Critical design elements of current linear and real-time two-dimensional (2D) measurement systems are highlighted, and the development of a three dimensional (3D) EFI system is presented. Demonstrations for structural, electronic, human, and memory applications are shown. Recent work demonstrates that phonons may be used to create and annihilate electric dipoles within structures. Phonon induced dipoles are ephemeral and their polarization, strength, and location may be quantitatively characterized by EFI providing a new subsurface Phonon-EFI imaging technology. Results from real-time imaging of combustion and ion flow, and their measurement complications, will be discussed. Extensions to environment, Space and subterranean applications will be presented, and initial results for quantitative characterizing material properties are shown. A wearable EFI system has been developed by using fundamental EFI concepts. These new EFI capabilities are demonstrated to characterize electric charge distribution creating a new field of study embracing areas of interest including electrostatic discharge (ESD) mitigation, manufacturing quality control, crime scene forensics, design and materials selection for advanced sensors, combustion science, on-orbit space potential, container inspection, remote characterization of electronic circuits and level of activation, dielectric morphology of

  3. Improvement of Sidestream Dark Field Imaging with an Image Acquisition Stabilizer

    NARCIS (Netherlands)

    G. Balestra (Gianmarco); R. Bezemer (Rick); E.C. Boerma (Christiaan); Z-Y. Yong (Ze-Yie); K.D. Sjauw (Krishan); A.E. Engstrom (Annemarie); M. Koopmans (Matty); C. Ince (Can)


    textabstractBackground: In the present study we developed, evaluated in volunteers, and clinically validated an image acquisition stabilizer (IAS) for Sidestream Dark Field (SDF) imaging.Methods: The IAS is a stainless steel sterilizable ring which fits around the SDF probe tip. The IAS creates

  4. Improvement of Sidestream Dark Field Imaging with an Image Acquisition Stabilizer

    NARCIS (Netherlands)

    Balestra, Gianmarco M.; Bezemer, Rick; Boerma, E. Christiaan; Yong, Ze-Yie; Sjauw, Krishan D.; Engstrom, Annemarie E.; Koopmans, Matty; Ince, Can


    ABSTRACT: BACKGROUND: In the present study we developed, evaluated in volunteers, and clinically validated an image acquisition stabilizer (IAS) for Sidestream Dark Field (SDF) imaging. METHODS: The IAS is a stainless steel sterilizable ring which fits around the SDF probe tip. The IAS creates

  5. Electric field effects in scanning tunneling microscope imaging

    DEFF Research Database (Denmark)

    Stokbro, Kurt; Quaade, Ulrich; Grey, Francois


    We present a high-voltage extension of the Tersoff-Hamann theory of scanning tunneling microscope (STM) images, which includes the effect of the electric field between the tip and the sample. The theoretical model is based on first-principles electronic structure calculations and has no adjustable...

  6. Near-field acoustic imaging based on Laplacian sparsity

    DEFF Research Database (Denmark)

    Fernandez Grande, Efren; Daudet, Laurent


    We present a sound source identification method for near-field acoustic imaging of extended sources. The methodology is based on a wave superposition method (or equivalent source method) that promotes solutions with sparse higher order spatial derivatives. Instead of promoting direct sparsity...


    Energy Technology Data Exchange (ETDEWEB)

    Ryan, R. E. Jr. [Physics Department, University of California, Davis, CA 95616 (United States); McCarthy, P. J. [Observatories of the Carnegie Institute of Washington, Pasadena, CA 91101 (United States); Cohen, S. H.; Rutkowski, M. J.; Mechtley, M. R.; Windhorst, R. A. [School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287 (United States); Yan, H. [Center for Cosmology and Astroparticle Physics, Ohio State University, Columbus, OH 43210 (United States); Hathi, N. P. [Department of Physics and Astronomy, University of California, Riverside, CA 92521 (United States); Koekemoer, A. M.; Bond, H. E.; Bushouse, H. [Space Telescope Science Institute, Baltimore, MD 21218 (United States); O' Connell, R. W. [Department of Astronomy, University of Virginia, Charlottesville, VA 22904 (United States); Balick, B. [Department of Astronomy, University of Washington, Seattle, WA 98195 (United States); Calzetti, D. [Department of Astronomy, University of Massachusetts, Amherst, MA 01003 (United States); Crockett, R. M. [Department of Physics, University of Oxford, Oxford OX1 3PU (United Kingdom); Disney, M. [School of Physics and Astronomy, Cardiff University, Cardiff CF24 3AA (United Kingdom); Dopita, M. A. [Research School of Astronomy and Astrophysics, The Australian National University, Weston Creek, ACT 2611 (Australia); Frogel, J. A. [Galaxies Unlimited, Lutherville, MD 21093 (United States); Hall, D. N. B. [Institute for Astronomy, University of Hawaii, Honolulu, HI 96822 (United States); Holtzman, J. A., E-mail: [Department of Astronomy, New Mexico State University, Las Cruces, NM 88003 (United States); and others


    We present the size evolution of passively evolving galaxies at z {approx} 2 identified in Wide-Field Camera 3 imaging from the Early Release Science program. Our sample was constructed using an analog to the passive BzK galaxy selection criterion, which isolates galaxies with little or no ongoing star formation at z {approx}> 1.5. We identify 30 galaxies in {approx}40 arcmin{sup 2} to H < 25 mag. By fitting the 10-band Hubble Space Telescope photometry from 0.22 {mu}m {approx}< {lambda}{sub obs} {approx}< 1.6 {mu}m with stellar population synthesis models, we simultaneously determine photometric redshift, stellar mass, and a bevy of other population parameters. Based on the six galaxies with published spectroscopic redshifts, we estimate a typical redshift uncertainty of {approx}0.033(1 + z). We determine effective radii from Sersic profile fits to the H-band image using an empirical point-spread function. By supplementing our data with published samples, we propose a mass-dependent size evolution model for passively evolving galaxies, where the most massive galaxies (M{sub *} {approx} 10{sup 11} M{sub Sun }) undergo the strongest evolution from z {approx} 2 to the present. Parameterizing the size evolution as (1 + z){sup -{alpha}}, we find a tentative scaling of {alpha} Almost-Equal-To (- 0.6 {+-} 0.7) + (0.9 {+-} 0.4)log (M{sub *}/10{sup 9} M{sub Sun }), where the relatively large uncertainties reflect the poor sampling in stellar mass due to the low numbers of high-redshift systems. We discuss the implications of this result for the redshift evolution of the M{sub *}-R{sub e} relation for red galaxies.

  8. Development of a Data Reduction Algorithm for Optical Wide Field Patrol (OWL II: Improving Measurement of Lengths of Detected Streaks

    Directory of Open Access Journals (Sweden)

    Sun-Youp Park


    Full Text Available As described in the previous paper (Park et al. 2013, the detector subsystem of optical wide-field patrol (OWL provides many observational data points of a single artificial satellite or space debris in the form of small streaks, using a chopper system and a time tagger. The position and the corresponding time data are matched assuming that the length of a streak on the CCD frame is proportional to the time duration of the exposure during which the chopper blades do not obscure the CCD window. In the previous study, however, the length was measured using the diagonal of the rectangle of the image area containing the streak; the results were quite ambiguous and inaccurate, allowing possible matching error of positions and time data. Furthermore, because only one (position, time data point is created from one streak, the efficiency of the observation decreases. To define the length of a streak correctly, it is important to locate the endpoints of a streak. In this paper, a method using a differential convolution mask pattern is tested. This method can be used to obtain the positions where the pixel values are changed sharply. These endpoints can be regarded as directly detected positional data, and the number of data points is doubled by this result.

  9. Field-ion imaging of nano-objects at far-subangstrom resolution (United States)

    Sadanov, E. V.; Mazilova, T. I.; Mikhailovskij, I. M.; Ksenofontov, V. A.; Mazilov, A. A.


    Low-dimensional materials, such as carbon atomic chains, subnanoribbons, and primary tubular structures, exhibit extraordinary functional properties and hold promise as building blocks for applications in nanoelectronics, but they have only been studied theoretically. Hence there is an increasing need to characterize and image the materials in question at the best possible resolution. Here we demonstrate a possibility to observe the atomic structure of one-dimensional sub-nano-objects with a cryogenic field-ion microscope having a resolution below 0.4 Å. The far-subangstrom imaging described here is a general-purpose technique that can be applied to a wide range of low-dimensional systems.

  10. Imaging using long range dipolar field effects Nuclear magnetic resonance

    CERN Document Server

    Gutteridge, S


    The work in this thesis has been undertaken by the except where indicated in reference, within the Magnetic Resonance Centre, at the University of Nottingham during the period from October 1998 to March 2001. This thesis details the different characteristics of the long range dipolar field and its application to magnetic resonance imaging. The long range dipolar field is usually neglected in nuclear magnetic resonance experiments, as molecular tumbling decouples its effect at short distances. However, in highly polarised samples residual long range components have a significant effect on the evolution of the magnetisation, giving rise to multiple spin echoes and unexpected quantum coherences. Three applications utilising these dipolar field effects are documented in this thesis. The first demonstrates the spatial sensitivity of the signal generated via dipolar field effects in structured liquid state samples. The second utilises the signal produced by the dipolar field to create proton spin density maps. Thes...

  11. Homography Propagation and Optimization for Wide-Baseline Street Image Interpolation. (United States)

    Nie, Yongwei; Zhang, Zhensong; Sun, Hanqiu; Su, Tan; Li, Guiqing


    Wide-baseline street image interpolation is useful but very challenging. Existing approaches either rely on heavyweight 3D reconstruction or computationally intensive deep networks. We present a lightweight and efficient method which uses simple homography computing and refining operators to estimate piecewise smooth homographies between input views. To achieve the goal, we show how to combine homography fitting and homography propagation together based on reliable and unreliable superpixel discrimination. Such a combination, other than using homography fitting only, dramatically increases the accuracy and robustness of the estimated homographies. Then, we integrate the concepts of homography and mesh warping, and propose a novel homography-constrained warping formulation which enforces smoothness between neighboring homographies by utilizing the first-order continuity of the warped mesh. This further eliminates small artifacts of overlapping, stretching, etc. The proposed method is lightweight and flexible, allows wide-baseline interpolation. It improves the state of the art and demonstrates that homography computation suffices for interpolation. Experiments on city and rural datasets validate the efficiency and effectiveness of our method.

  12. Clustering phenotype populations by genome-wide RNAi and multiparametric imaging (United States)

    Fuchs, Florian; Pau, Gregoire; Kranz, Dominique; Sklyar, Oleg; Budjan, Christoph; Steinbrink, Sandra; Horn, Thomas; Pedal, Angelika; Huber, Wolfgang; Boutros, Michael


    Genetic screens for phenotypic similarity have made key contributions to associating genes with biological processes. With RNA interference (RNAi), highly parallel phenotyping of loss-of-function effects in cells has become feasible. One of the current challenges however is the computational categorization of visual phenotypes and the prediction of biological function and processes. In this study, we describe a combined computational and experimental approach to discover novel gene functions and explore functional relationships. We performed a genome-wide RNAi screen in human cells and used quantitative descriptors derived from high-throughput imaging to generate multiparametric phenotypic profiles. We show that profiles predicted functions of genes by phenotypic similarity. Specifically, we examined several candidates including the largely uncharacterized gene DONSON, which shared phenotype similarity with known factors of DNA damage response (DDR) and genomic integrity. Experimental evidence supports that DONSON is a novel centrosomal protein required for DDR signalling and genomic integrity. Multiparametric phenotyping by automated imaging and computational annotation is a powerful method for functional discovery and mapping the landscape of phenotypic responses to cellular perturbations. PMID:20531400

  13. Light field moment imaging with the ptychographic iterative engine

    Directory of Open Access Journals (Sweden)

    Zhilong Jiang


    Full Text Available The recently developed Light Field Moment Imaging (LMI is adopted to show the stereoscopic structure of the sample studied in Coherent Diffractive Imaging (CDI, where 3D image were always generated with complicated experimental procedure such as the rotation of the sample and time-consuming computation. The animation of large view angle can be generated with LMI very quickly, and the 3D structure of sample can be shown vividly. This method can find many applications for the coherent diffraction imaging with x-ray and electron beams, where a glimpse of the hierarchical structure required and the quick and simple 3D view of object is sufficient. The feasibility of this method is demonstrated theoretically and experimentally with a recently developed CDI method called Ptychographic Iterative Engine.

  14. Light field moment imaging with the ptychographic iterative engine

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Zhilong; Pan, Xinchen; Liu, Cheng, E-mail:, E-mail:; Zhu, Jianqiang [Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China); Wang, Ling, E-mail:, E-mail: [Department of Physics and Astronomy, KU Leuven, 3001, Heverlee (Belgium); NERF, 3001, Heverlee (Belgium)


    The recently developed Light Field Moment Imaging (LMI) is adopted to show the stereoscopic structure of the sample studied in Coherent Diffractive Imaging (CDI), where 3D image were always generated with complicated experimental procedure such as the rotation of the sample and time-consuming computation. The animation of large view angle can be generated with LMI very quickly, and the 3D structure of sample can be shown vividly. This method can find many applications for the coherent diffraction imaging with x-ray and electron beams, where a glimpse of the hierarchical structure required and the quick and simple 3D view of object is sufficient. The feasibility of this method is demonstrated theoretically and experimentally with a recently developed CDI method called Ptychographic Iterative Engine.

  15. Conformal and other image warpings for reading with field defect (United States)

    Juday, Richard D.; Barton, R. Shane; Johnson, Curtis D.; Loshin, David S.


    Certain visual functions, such as reading, are dependent on the high resolution capability of the central visual field. When that area becomes dysfunctional the tasks become difficult or impossible. We have proposed an image warping prosthesis, in which the structure of the image that would otherwise be unseen owing to the scotoma is moved outward and onto portions of the retina that still function. Previously we used normally sighted volunteers with fixated foveation, synthetic scotomas, a limited form of image warping, and externally controlled reading saccades. Their reading rate showed improvement in a significant number of instances. In the next stage, we are prepared to use volunteers with actual, not synthesized, scotomas. The results will be used to design realistic prostheses. Different warpings may better help other visual tasks such as facial recognition. Some of the image warpings designed for reading are shown here and our rationale for considering them are given.

  16. A new low cost wide-field illumination method for photooxidation of intracellular fluorescent markers.

    Directory of Open Access Journals (Sweden)

    Manoel da Silva Filho

    Full Text Available Analyzing cell morphology is crucial in the fields of cell biology and neuroscience. One of the main methods for evaluating cell morphology is by using intracellular fluorescent markers, including various commercially available dyes and genetically encoded fluorescent proteins. These markers can be used as free radical sources in photooxidation reactions, which in the presence of diaminobenzidine (DAB forms an opaque and electron-dense precipitate that remains localized within the cellular and organelle membranes. This method confers many methodological advantages for the investigator, including absence of photo-bleaching, high visual contrast and the possibility of correlating optical imaging with electron microscopy. However, current photooxidation techniques require the continuous use of fluorescent or confocal microscopes, which wastes valuable mercury lamp lifetime and limits the conversion process to a few cells at a time. We developed a low cost optical apparatus for performing photooxidation reactions and propose a new procedure that solves these methodological restrictions. Our "photooxidizer" consists of a high power light emitting diode (LED associated with a custom aluminum and acrylic case and a microchip-controlled current source. We demonstrate the efficacy of our method by converting intracellular DiI in samples of developing rat neocortex and post-mortem human retina. DiI crystals were inserted in the tissue and allowed to diffuse for 20 days. The samples were then processed with the new photooxidation technique and analyzed under optical microscopy. The results show that our protocols can unveil the fine morphology of neurons in detail. Cellular structures such as axons, dendrites and spine-like appendages were well defined. In addition to its low cost, simplicity and reliability, our method precludes the use of microscope lamps for photooxidation and allows the processing of many labeled cells simultaneously in relatively

  17. Imaging the atomic orbitals of carbon atomic chains with field-emission electron microscopy (United States)

    Mikhailovskij, I. M.; Sadanov, E. V.; Mazilova, T. I.; Ksenofontov, V. A.; Velicodnaja, O. A.


    A recently developed high-field technique of atomic chains preparation has made it possible to attain the ultrahigh resolution of field-emission electron microscopy (FEEM), which can be used to direct imaging the intra-atomic electronic structure. By applying cryogenic FEEM, we are able to resolve the spatial configuration of atomic orbitals, which correspond to quantized states of the end atom in free-standing carbon atomic chains. Knowledge of the intra-atomic structure will make it possible to visualize generic aspects of quantum mechanics and also lead to approaches for a wide range of nanotechnological applications.

  18. Wide-Field Gamma-Spectrometer BDRG: GRB Monitor On-Board the Lomonosov Mission (United States)

    Svertilov, S. I.; Panasyuk, M. I.; Bogomolov, V. V.; Amelushkin, A. M.; Barinova, V. O.; Galkin, V. I.; Iyudin, A. F.; Kuznetsova, E. A.; Prokhorov, A. V.; Petrov, V. L.; Rozhkov, G. V.; Yashin, I. V.; Gorbovskoy, E. S.; Lipunov, V. M.; Park, I. H.; Jeong, S.; Kim, M. B.


    The study of GRB prompt emissions (PE) is one of the main goals of the Lomonosov space mission. The payloads of the GRB monitor (BDRG) with the wide-field optical cameras (SHOK) and the ultra-fast flash observatory (UFFO) onboard the Lomonosov satellite are intended for the observation of GRBs, and in particular, their prompt emissions. The BDRG gamma-ray spectrometer is designed to obtain the temporal and spectral information of GRBs in the energy range of 10-3000 keV as well as to provide GRB triggers on several time scales (10 ms, 1 s and 20 s) for ground and space telescopes, including the UFFO and SHOK. The BDRG instrument consists of three identical detector boxes with axes shifted by 90° from each other. This configuration allows us to localize a GRB source in the sky with an accuracy of ˜ 2°. Each BDRG box contains a phoswich NaI(Tl)/CsI(Tl) scintillator detector. A thick CsI(Tl) crystal in size of \\varnothing 130 × 17 mm is placed underneath the NaI(Tl) as an active shield in the soft energy range and as the main detector in the hard energy range. The ratio of the CsI(Tl) to NaI(Tl) event rates at varying energies can be employed as an independent metric to distinguish legitimate GRB signals from false positives originating from electrons in near-Earth vicinities. The data from three detectors are collected in a BA BDRG information unit, which generates a GRB trigger and a set of data frames in output format. The scientific data output is ˜ 500 Mb per day, including ˜ 180 Mb of continuous data for events with durations in excess of 100 ms for 16 channels in each detector, detailed energy spectra, and sets of frames with ˜ 5 Mb of detailed information for each burst-like event. A number of pre-flight tests including those for the trigger algorithm and calibration were carried out to confirm the reliability of the BDRG for operation in space.

  19. High-throughput dual-color precision imaging for brain-wide mapping of the connectome with cytoarchitectonic landmarks at the cellular level (Conference Presentation) (United States)

    Luo, Qingming; Gong, Hui; Yuan, Jing; Li, Xiangning; Li, Anan; Xu, Tonghui


    Deciphering the fine morphology and precise location of neurons and neural circuits are crucial to enhance our understanding of brain function and diseases. Traditionally, we have to map brain images to coarse axial-sampling planar reference atlases to orient neural structures. However, this means might fail to orient neural projections at single-cell resolution due to position errors resulting from individual differences at the cellular level. Here, we present a high-throughput imaging method that can automatically obtain the fine morphologies and precise locations of both neurons and circuits, employing wide-field large-volume tomography to acquire three-dimensional images of thick tissue and implementing real-time soma counterstaining to obtain cytoarchitectonic landmarks during the imaging process. The reconstruction and orientation of brain-wide neural circuits at single-neuron resolution can be accomplished for the same mouse brain without additional counterstains or image registration. Using our method, mouse brain imaging datasets of multiple type-specific neurons and circuits were successfully acquired, demonstrating the versatility. The results show that the simultaneous acquisition of labeled neural structures and cytoarchitecture reference at single-neuron resolution in the same brain greatly facilitates precise tracing of long-range projections and accurate locating of nuclei. Our method provides a novel and effective tool for application in studies on genetic dissection, brain function and the pathology of the nervous system.

  20. [Optimization of Three-dimensional Ultrashort Echo Time Magnetic Resonance Imaging at a Low Field]. (United States)

    Huang, Yuli; Du, Yiping


    Conventional magnetic resonance (MR) pulse sequences typically have an echo time (TE) of 1 ms or longer, providing an excellent contrast between different soft tissues. However, some short T2 tissues appear dark in conventional MR images because the signal from these tissues has decayed to nearly zero before the center of k-space is acquired. Because of the ability of directly imaging short T2 tissues, ultrashort echo time technique has been widely studied in recent years. An overwhelming majority of the studies were carried out at high fields, while many low- field scanner systems are still used in developing countries. To investigate the effects of the delay between analog-to-digital converter sampling and the readout gradient, the TE of the second echo used to calculate the R2 * map, and the undersampling ratio on the results of three-dimensional (3D) ultrashort echo time imaging at a low field, we implemented a 3D ultrashort echo time sequence on a 0. 35T scanner. Different parameters were used and the reconstructed images and R2 * maps were compared. Images reconstructed with slightly varying delays appeared quite different. Different contrast between short and long T2 tissues were found in R2 * maps calculated with different echoes. The result of undersampling study indicated that excessive undersampling could cause unwanted blurring, making it difficult to better visualize the short T2 tissues in the R2 * map. The results suggested that cautions should be taken in the choice of these parameters in 3D ultrashort echo time imaging. Short T2 tissues can be visualized with appropriate imaging parameters at this low field.

  1. Range-gated imaging for near-field target identification

    Energy Technology Data Exchange (ETDEWEB)

    Yates, G.J.; Gallegos, R.A.; McDonald, T.E. [and others


    The combination of two complementary technologies developed independently at Los Alamos National Laboratory (LANL) and Sandia National Laboratory (SNL) has demonstrated feasibility of target detection and image capture in a highly light-scattering, medium. The technique uses a compact SNL developed Photoconductive Semiconductor Switch/Laser Diode Array (PCSS/LDA) for short-range (distances of 8 to 10 m) large Field-Of-View (FOV) target illumination. Generation of a time-correlated echo signal is accomplished using a photodiode. The return image signal is recorded with a high-speed shuttered Micro-Channel-Plate Image Intensifier (MCPII), declined by LANL and manufactured by Philips Photonics. The MCPII is rated using a high-frequency impedance-matching microstrip design to produce 150 to 200 ps duration optical exposures. The ultra first shuttering producer depth resolution of a few inches along the optic axis between the MCPII and the target, producing enhanced target images effectively deconvolved from noise components from the scattering medium in the FOV. The images from the MCPII are recorded with an RS-170 Charge-Coupled-Device camera and a Big Sky, Beam Code, PC-based digitizer frame grabber and analysis package. Laser pulse data were obtained by the but jitter problems and spectral mismatches between diode spectral emission wavelength and MCPII photocathode spectral sensitivity prevented the capture of fast gating imaging with this demonstration system. Continued development of the system is underway.

  2. Far-field superresolution by imaging of resonance scattering

    KAUST Repository

    Schuster, Gerard T.


    We show that superresolution imaging in the far-field region of the sources and receivers is theoretically and practically possible if migration of resonant multiples is employed. A resonant multiple is one that bounces back and forth between two scattering points; it can also be the multiple between two smoothly varying interfaces as long as the reflection wave paths partially overlap and reflect from the same Fresnel zone. For a source with frequency f, compared to a one-way trip, N round trips in propagating between two scatterers increase the effective frequency by 2N × f and decrease the effective wavelength by λ/(2N). Thus, multiples can, in principle, be used as high-frequency probes to estimate detailed properties of layers. Tests with both synthetic and field data validate this claim. Improved resolution by multiple imaging is not only feasible for crustal reflections, but might be applicable to mantle and core reverberations recorded by earthquake seismologists.

  3. Classification of hyperspectral images based on conditional random fields (United States)

    Hu, Yang; Saber, Eli; Monteiro, Sildomar T.; Cahill, Nathan D.; Messinger, David W.


    A significant increase in the availability of high resolution hyperspectral images has led to the need for developing pertinent techniques in image analysis, such as classification. Hyperspectral images that are correlated spatially and spectrally provide ample information across the bands to benefit this purpose. Conditional Random Fields (CRFs) are discriminative models that carry several advantages over conventional techniques: no requirement of the independence assumption for observations, flexibility in defining local and pairwise potentials, and an independence between the modules of feature selection and parameter leaning. In this paper we present a framework for classifying remotely sensed imagery based on CRFs. We apply a Support Vector Machine (SVM) classifier to raw remotely sensed imagery data in order to generate more meaningful feature potentials to the CRFs model. This approach produces promising results when tested with publicly available AVIRIS Indian Pine imagery.

  4. Improvement of sidestream dark field imaging with an image acquisition stabilizer. (United States)

    Balestra, Gianmarco M; Bezemer, Rick; Boerma, E Christiaan; Yong, Ze-Yie; Sjauw, Krishan D; Engstrom, Annemarie E; Koopmans, Matty; Ince, Can


    In the present study we developed, evaluated in volunteers, and clinically validated an image acquisition stabilizer (IAS) for Sidestream Dark Field (SDF) imaging. The IAS is a stainless steel sterilizable ring which fits around the SDF probe tip. The IAS creates adhesion to the imaged tissue by application of negative pressure. The effects of the IAS on the sublingual microcirculatory flow velocities, the force required to induce pressure artifacts (PA), the time to acquire a stable image, and the duration of stable imaging were assessed in healthy volunteers. To demonstrate the clinical applicability of the SDF setup in combination with the IAS, simultaneous bilateral sublingual imaging of the microcirculation were performed during a lung recruitment maneuver (LRM) in mechanically ventilated critically ill patients. One SDF device was operated handheld; the second was fitted with the IAS and held in position by a mechanic arm. Lateral drift, number of losses of image stability and duration of stable imaging of the two methods were compared. Five healthy volunteers were studied. The IAS did not affect microcirculatory flow velocities. A significantly greater force had to applied onto the tissue to induced PA with compared to without IAS (0.25 +/- 0.15 N without vs. 0.62 +/- 0.05 N with the IAS, p lateral SDF image stability and thereby increased the critical force required to induce pressure artifacts. The IAS ensured a significantly increased duration of maintaining a stable image sequence.

  5. Rock glaciers Gruben, Muragl and Murtel, Switzerland: Area-wide flow fields, Version 1 (United States)

    National Aeronautics and Space Administration — Besides their thermal and mechanical properties, rock glaciers are essentially defined by their kinematics. Knowledge of the permafrost flow field provides important...

  6. Superresolution Near-field Imaging with Surface Waves

    KAUST Repository

    Fu, Lei


    We present the theory for near-field superresolution imaging with surface waves and time reverse mirrors (TRMs). Theoretical formulas and numerical results show that applying the TRM operation to surface waves in an elastic half-space can achieve superresolution imaging of subwavelength scatterers if they are located less than about 1/2 of the shear wavelength from the source line. We also show that the TRM operation for a single frequency is equivalent to natural migration, which uses the recorded data to approximate the Green’s functions for migration, and only costs O(N4) algebraic operations for poststack migration compared to O(N6) operations for natural prestack migration. Here, we assume the sources and receivers are on an N × N grid and there are N2 trial image points on the free surface. Our theoretical predictions of superresolution are validated with tests on synthetic data. The field-data tests suggest that hidden faults at the near surface can be detected with subwavelength imaging of surface waves by using the TRM operation if they are no deeper than about 1/2 the dominant shear wavelength.

  7. Detecting field cancerization using a hyperspectral imaging system. (United States)

    Neittaanmäki-Perttu, Noora; Grönroos, Mari; Tani, Taneli; Pölönen, Ilkka; Ranki, Annamari; Saksela, Olli; Snellman, Erna


    Field cancerization denotes subclinical abnormalities in a tissue chronically exposed to UV radiation. These abnormalities can be found surrounding the clinically visible actinic keratoses. The aim of this study was to test the feasibility of a hyperspectral imaging system in the detection of multiple clinical and subclinical AKs for early treatment of the affected areas. Altogether 52 clinical AKs in 12 patients were included in this study. In six patients digital photos were taken of the naive AKs, and again after methylaminolevulinate(MAL)-fluorescence diagnosis which was used to teach HIS to find subclinical lesions. After 2-3 days when the MAL had vanished, the hyperspectral images were taken. Biopsies were taken from clinical AKs, healthy-looking skin and several suspected subclinical AKs. In the other six patients digital and hyperspectral images were taken of the naive AKs followed by one biopsy per patient. HIS detected all clinically visible 52 AKs and numerous subclinical lesions. The histopathology of the 33 biopsied lesions were concordant with the HIS results showing either AK (n = 28) or photodamage (n = 5). Of the 28 histopathologically confirmed AKs, 16 were subclinical. A specific diffuse reflectance spectrum of an AK and healthy skin was defined. The hyperspectral imaging system offers a new, non-invasive method for early detection of field cancerization. Lasers Surg. Med. 45:410-417, 2013. © 2013 Wiley Periodicals, Inc. © 2013 Wiley Periodicals, Inc.

  8. Body-wide hierarchical fuzzy modeling, recognition, and delineation of anatomy in medical images. (United States)

    Udupa, Jayaram K; Odhner, Dewey; Zhao, Liming; Tong, Yubing; Matsumoto, Monica M S; Ciesielski, Krzysztof C; Falcao, Alexandre X; Vaideeswaran, Pavithra; Ciesielski, Victoria; Saboury, Babak; Mohammadianrasanani, Syedmehrdad; Sin, Sanghun; Arens, Raanan; Torigian, Drew A


    To make Quantitative Radiology (QR) a reality in radiological practice, computerized body-wide Automatic Anatomy Recognition (AAR) becomes essential. With the goal of building a general AAR system that is not tied to any specific organ system, body region, or image modality, this paper presents an AAR methodology for localizing and delineating all major organs in different body regions based on fuzzy modeling ideas and a tight integration of fuzzy models with an Iterative Relative Fuzzy Connectedness (IRFC) delineation algorithm. The methodology consists of five main steps: (a) gathering image data for both building models and testing the AAR algorithms from patient image sets existing in our health system; (b) formulating precise definitions of each body region and organ and delineating them following these definitions; (c) building hierarchical fuzzy anatomy models of organs for each body region; (d) recognizing and locating organs in given images by employing the hierarchical models; and (e) delineating the organs following the hierarchy. In Step (c), we explicitly encode object size and positional relationships into the hierarchy and subsequently exploit this information in object recognition in Step (d) and delineation in Step (e). Modality-independent and dependent aspects are carefully separated in model encoding. At the model building stage, a learning process is carried out for rehearsing an optimal threshold-based object recognition method. The recognition process in Step (d) starts from large, well-defined objects and proceeds down the hierarchy in a global to local manner. A fuzzy model-based version of the IRFC algorithm is created by naturally integrating the fuzzy model constraints into the delineation algorithm. The AAR system is tested on three body regions - thorax (on CT), abdomen (on CT and MRI), and neck (on MRI and CT) - involving a total of over 35 organs and 130 data sets (the total used for model building and testing). The training and

  9. Improvement of Sidestream Dark Field Imaging with an Image Acquisition Stabilizer

    Directory of Open Access Journals (Sweden)

    Sjauw Krishan D


    Full Text Available Abstract Background In the present study we developed, evaluated in volunteers, and clinically validated an image acquisition stabilizer (IAS for Sidestream Dark Field (SDF imaging. Methods The IAS is a stainless steel sterilizable ring which fits around the SDF probe tip. The IAS creates adhesion to the imaged tissue by application of negative pressure. The effects of the IAS on the sublingual microcirculatory flow velocities, the force required to induce pressure artifacts (PA, the time to acquire a stable image, and the duration of stable imaging were assessed in healthy volunteers. To demonstrate the clinical applicability of the SDF setup in combination with the IAS, simultaneous bilateral sublingual imaging of the microcirculation were performed during a lung recruitment maneuver (LRM in mechanically ventilated critically ill patients. One SDF device was operated handheld; the second was fitted with the IAS and held in position by a mechanic arm. Lateral drift, number of losses of image stability and duration of stable imaging of the two methods were compared. Results Five healthy volunteers were studied. The IAS did not affect microcirculatory flow velocities. A significantly greater force had to applied onto the tissue to induced PA with compared to without IAS (0.25 ± 0.15 N without vs. 0.62 ± 0.05 N with the IAS, p Conclusions The present study has validated the use of an IAS for improvement of SDF imaging by demonstrating that the IAS did not affect microcirculatory perfusion in the microscopic field of view. The IAS improved both axial and lateral SDF image stability and thereby increased the critical force required to induce pressure artifacts. The IAS ensured a significantly increased duration of maintaining a stable image sequence.

  10. A deep, wide-field study of Holmberg II with Suprime-Cam: evidence for ram pressure stripping (United States)

    Bernard, Edouard J.; Ferguson, Annette M. N.; Barker, Michael K.; Irwin, Michael J.; Jablonka, Pascale; Arimoto, Nobuo


    We present a deep, wide-field optical study of the M81 group dwarf galaxy Holmberg II (HoII) based on Subaru/Suprime-Cam imaging. Individual stars are resolved down to I ˜ 25.2, that is, about 1.5 mag below the tip of the red giant branch (RGB). We use resolved star counts in the outskirts of the galaxy to measure the radial surface brightness profile down to μV ˜ 32 mag arcsec-2, from which we determine a projected exponential scalelength of 0.70 ± 0.01 arcmin (i.e. 0.69 ± 0.01 kpc). The composite profile, ranging from the cored centre out to R = 7 arcmin, is best fitted by an Elson-Fall-Freeman profile which gives a half-light radius of 1.41 ± 0.04 arcmin (i.e. 1.39 ± 0.04 kpc), and an absolute magnitude MV = -16.3. The low surface brightness stellar component of HoII is regular and symmetric and has an extent much smaller than the vast H I cloud in which it is embedded. We compare the spatial distribution of the young, intermediate-age and old stellar populations, and find that the old RGB stars are significantly more centrally concentrated than the young stellar populations, contrary to what is observed in most dwarf galaxies of the local Universe. We discuss these properties in the context of the comet-like distribution of H I gas around HoII, and argue for the presence of a hot intragroup medium in the vicinity of HoII to explain the contrasting morphologies of gas and stars. Based on data collected at the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan.


    Energy Technology Data Exchange (ETDEWEB)

    Fraser, Wesley C. [Herzberg Institute of Astrophysics, 5071 West Saanich Road Victoria, BC V9E 2E7 (Canada); Brown, Michael E. [California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91101 (United States); Glass, Florian, E-mail: [Observatoire de Genve, Universit de Genve, 51 chemin des Maillettes, CH-1290 Sauverny (Switzerland)


    Here, we present additional photometry of targets observed as part of the Hubble Wide Field Camera 3 (WFC3) Test of Surfaces in the Outer Solar System. Twelve targets were re-observed with the WFC3 in the optical and NIR wavebands designed to complement those used during the first visit. Additionally, all of the observations originally presented by Fraser and Brown were reanalyzed through the same updated photometry pipeline. A re-analysis of the optical and NIR color distribution reveals a bifurcated optical color distribution and only two identifiable spectral classes, each of which occupies a broad range of colors and has correlated optical and NIR colors, in agreement with our previous findings. We report the detection of significant spectral variations on five targets which cannot be attributed to photometry errors, cosmic rays, point-spread function or sensitivity variations, or other image artifacts capable of explaining the magnitude of the variation. The spectrally variable objects are found to have a broad range of dynamical classes and absolute magnitudes, exhibit a broad range of apparent magnitude variations, and are found in both compositional classes. The spectrally variable objects with sufficiently accurate colors for spectral classification maintain their membership, belonging to the same class at both epochs. 2005 TV189 exhibits a sufficiently broad difference in color at the two epochs that span the full range of colors of the neutral class. This strongly argues that the neutral class is one single class with a broad range of colors, rather than the combination of multiple overlapping classes.

  12. PMAS: The Potsdam Multi-Aperture Spectrophotometer. II. The Wide Integral Field Unit PPak

    NARCIS (Netherlands)

    Kelz, Andreas; Verheijen, Marc A. W.; Roth, Martin M.; Bauer, Svend M.; Becker, Thomas; Paschke, Jens; Popow, Emil; Sánchez, Sebastian F.; Laux, Uwe


    PPak is a new fiber-based integral field unit (IFU) developed at the Astrophysical Institute of Potsdam and implemented as a module into the existing Potsdam Multi-Aperture Spectrophotometer (PMAS) spectrograph. The purpose of PPak is to provide an extended field of view with a large

  13. Magnetic Fields In NGC 6946 Using Wide-Band Radio Polarimetry

    NARCIS (Netherlands)

    Williams, Anna; Heald, George; Wilcots, Eric M.; Gould Zweibel, Ellen

    Magnetic fields are important ingredients in the interstellar medium of galaxies. They accelerate cosmic rays, affect star formation, and regulate the redistribution of matter and energy. Despite their ubiquitous presence, the growth and coevolution of magnetic fields with galactic processes are not

  14. Initial evaluation of safety of wide-field irradiation in the treatment of hematopoietic neoplasia in the cat. (United States)

    Husbands, Brian D; McNiel, Elizabeth A; Modiano, Jaime F


    Localized radiation therapy is well tolerated in cats with confined tumors; however, the use of wide-field radiation therapy to treat disseminated neoplasia has not been evaluated systematically in this species. Wide-field external beam radiation therapy, which we define as irradiation of cranial or caudal halves of the body either individually or sequentially, was undertaken as an experimental option to treat cats with either chemotherapy-refractory or naive hematopoietic neoplasia considered to have a poor prognosis. Fifteen cats with hematopoietic malignancies received wide-field external beam radiation therapy between 2003 and 2006. Cats received 8 Gy delivered in 4 Gy fractions with 60Co photons. Treatment-related toxicity was scored according to criteria established by the Veterinary Cooperative Oncology Group. Animals without preexisting abnormalities on hemograms exhibited no or mild (Grade 1 or 2) hematopoietic toxicity. Although most cats (14 of 15) had preexisting gastrointestinal (GI) signs, these signs were stable (29%) or improved (42%) following irradiation. Worsening GI signs following irradiation occurred transiently in two cats and in association with progressive disease in two others. No pulmonary, renal, hepatic, or dermatologic toxicities were detected. In summary, wide-field external beam radiation therapy can be administered safely to, and may provide therapeutic benefit for, cats with disseminated hematopoietic neoplasia.

  15. Low-Field Magnetic Resonance Imaging of Canine Hydrocephalus

    Directory of Open Access Journals (Sweden)

    Z. Adamiak* and M. Jaskólska and A. Pomianowski1


    Full Text Available The aim of presented study was to evaluate selected surface spine coil, and low-field magnetic resonance (MR selected sequences in diagnosing hydrocephalus in dogs. This paper discusses 19 dogs (14 canine patients with hydrocephalus and 5 healthy dogs, of five breeds, subjected to low-field magnetic resonance imaging (MRI of hydrocephalus. Area of the lateral ventricles and brain were examined in dogs with hydrocephalus using low-field MRI (at 0.25 Tesla. The MRI of FSE REL, SE, FLAIR, STIR, 3D HYCE, T3DT1, GE STIR 3D and 3D SHARC sequences with an indication of the most effective sequences are described. Additionally, coils for MR were compared, and models for infusion anesthesia were described. As a result of performed study all estimated sequences were diagnostically useful. However, spinal coil No. 2 (ESAOTE was the most optimal for examining and positioning the cranium.

  16. Image Reconstruction Image reconstruction by using local inverse for full field of view

    CERN Document Server

    Yang, Kang; Yang, Xintie; Zhao, Shuang-Ren


    The iterative refinement method (IRM) has been very successfully applied in many different fields for examples the modern quantum chemical calculation and CT image reconstruction. It is proved that the refinement method can create an exact inverse from an approximate inverse with a few iterations. The IRM has been used in CT image reconstruction to lower the radiation dose. The IRM utilize the errors between the original measured data and the recalculated data to correct the reconstructed images. However if it is not smooth inside the object, there often is an over-correction along the boundary of the organs in the reconstructed images. The over-correction increase the noises especially on the edges inside the image. One solution to reduce the above mentioned noises is using some kind of filters. Filtering the noise before/after/between the image reconstruction processing. However filtering the noises also means reduce the resolution of the reconstructed images. The filtered image is often applied to the imag...

  17. Active optics and the axisymmetric case: MINITRUST wide-field three-reflection telescopes with mirrors aspherized from tulip and vase forms (United States)

    Lemaitre, Gerard R.; Montiel, Pierre; Joulie, Patrice; Dohlen, Kjetil; Lanzoni, Patrick


    Wide-field astronomy requires larger size telescopes. Compared to the catadioptric Schmidt, the optical properties of a three mirror telescope provides significant advantages. (1) The flat field design is anastigmatic at any wavelength, (2) the system is extremely compact -- four times shorter than a Schmidt -- and, (3) compared to a Schmidt with refractive corrector -- requiring the polishing of three optical surfaces --, the presently proposed Modified-Rumsey design uses all of eight available free parameters of a flat fielded anastigmatic three mirror telescope for mirrors generated by active optics methods. Compared to a Rumsey design, these parameters include the additional slope continuity condition at the primary-tertiary link for in-situ stressing and aspherization from a common sphere. Then, active optics allows the polishing of only two spherical surfaces: the combined primary-tertiary mirror and the secondary mirror. All mirrors are spheroids of the hyperboloid type. This compact system is of interest for space and ground-based astronomy and allows to built larger wide-field telescopes such as demonstrated by the design and construction of identical telescopes MINITRUST-1 and -2, f/5 - 2° FOV, consisting of an in-situ stressed double vase form primary-tertiary and of a stress polished tulip form secondary. Optical tests of these telescopes, showing diffraction limited images, are presented.

  18. The engineering prototype of the wide-field Cherenkov telescope for the Yakutsk array (United States)

    Ivanov, A. A.; Knurenko, S. P.; Krasilnikov, A. D.; Ksenofontov, I. V.; Petrov, Z. E.; Pravdin, M. I.; Timofeev, L. V.; Sleptsov, I. Ye


    The Yakutsk array group is developing the wide FOV Cherenkov telescopes to be operated in coincidence with the surface detectors of the array under modernization. Currently the engineering prototype of the reflecting telescope with front-end electronics is designed and assembled to prove the feasibility of the concept. In this report the status and parameters of the engineering prototype are presented.

  19. Magnetic resonance imaging and spectroscopy at ultra high fields

    Energy Technology Data Exchange (ETDEWEB)

    Neuberger, Thomas


    The goal of the work presented in this thesis was to explore the possibilities and limitations of MRI / MRS using an ultra high field of 17.6 tesla. A broad range of specific applications and MR methods, from MRI to MRSI and MRS were investigated. The main foci were on sodium magnetic resonance spectroscopic imaging of rodents, magnetic resonance spectroscopy of the mouse brain, and the detection of small amounts of iron labeled stem cells in the rat brain using MRI Sodium spectroscopic imaging was explored since it benefits tremendously from the high magnetic field. Due to the intrinsically low signal in vivo, originating from the low concentrations and short transverse relaxation times, only limited results have been achieved by other researchers until now. Results in the literature include studies conducted on large animals such as dogs to animals as small as rats. No studies performed on mice have been reported, despite the fact that the mouse is the most important laboratory animal due to the ready availability of transgenic strains. Hence, this study concentrated on sodium MRSI of small rodents, mostly mice (brain, heart, and kidney), and in the case of the brain on young rats. The second part of this work concentrated on proton magnetic resonance spectroscopy of the rodent brain. Due to the high magnetic field strength not only the increasing signal but also the extended spectral resolution was advantageous for such kind of studies. The difficulties/limitations of ultra high field MRS were also investigated. In the last part of the presented work detection limits of iron labeled stem cells in vivo using magnetic resonance imaging were explored. The studies provided very useful benchmarks for future researchers in terms of the number of labeled stem cells that are required for high-field MRI studies. Overall this work has shown many of the benefits and the areas that need special attention of ultra high fields in MR. Three topics in MRI, MRS and MRSI were

  20. Photometric Calibration and Image Stitching for a Large Field of View Multi-Camera System

    Directory of Open Access Journals (Sweden)

    Yu Lu


    Full Text Available A new compact large field of view (FOV multi-camera system is introduced. The camera is based on seven tiny complementary metal-oxide-semiconductor sensor modules covering over 160° × 160° FOV. Although image stitching has been studied extensively, sensor and lens differences have not been considered in previous multi-camera devices. In this study, we have calibrated the photometric characteristics of the multi-camera device. Lenses were not mounted on the sensor in the process of radiometric response calibration to eliminate the influence of the focusing effect of uniform light from an integrating sphere. Linearity range of the radiometric response, non-linearity response characteristics, sensitivity, and dark current of the camera response function are presented. The R, G, and B channels have different responses for the same illuminance. Vignetting artifact patterns have been tested. The actual luminance of the object is retrieved by sensor calibration results, and is used to blend images to make panoramas reflect the objective luminance more objectively. This compensates for the limitation of stitching images that are more realistic only through the smoothing method. The dynamic range limitation of can be resolved by using multiple cameras that cover a large field of view instead of a single image sensor with a wide-angle lens. The dynamic range is expanded by 48-fold in this system. We can obtain seven images in one shot with this multi-camera system, at 13 frames per second.

  1. Integrating Field-Centered, Project Based Activities with Academic Year Coursework: A Curriculum Wide Approach (United States)

    Kelso, P. R.; Brown, L. M.


    Based upon constructivist principles and the recognition that many students are motivated by hands-on activities and field experiences, we designed a new undergraduate curriculum at Lake Superior State University. One of our major goals was to develop stand-alone field projects in most of the academic year courses. Examples of courses impacted include structural geology, geophysics, and geotectonics, Students learn geophysical concepts in the context of near surface field-based geophysical studies while students in structural geology learn about structural processes through outcrop study of fractures, folds and faults. In geotectonics students learn about collisional and rifting processes through on-site field studies of specific geologic provinces. Another goal was to integrate data and samples collected by students in our sophomore level introductory field course along with stand-alone field projects in our clastic systems and sequence stratigraphy courses. Our emphasis on active learning helps students develop a meaningful geoscience knowledge base and complex reasoning skills in authentic contexts. We simulate the activities of practicing geoscientists by engaging students in all aspects of a project, for example: field-oriented project planning and design; acquiring, analyzing, and interpreting data; incorporating supplemental material and background data; and preparing oral and written project reports. We find through anecdotal evidence including student comments and personal observation that the projects stimulate interest, provide motivation for learning new concepts, integrate skill and concept acquisition vertically through the curriculum, apply concepts from multiple geoscience subdisiplines, and develop soft skills such as team work, problem solving, critical thinking and communication skills. Through this projected-centered Lake Superior State University geology curriculum students practice our motto of "learn geology by doing geology."

  2. Distortion-free magnetic resonance imaging in the zero-field limit


    Kelso, Nathan


    MRI is a powerful technique for clinical diagnosis and materials characterization. Images are acquired in a homogeneous static magnetic field much higher than the fields generated across the field of view by the spatially encoding field gradients. Without such a high field, the concomitant components of the field gradient dictated by Maxwell's equations lead to severe distortions that make imaging impossible with conventional MRI encoding. In this paper, we present a distortion-free image ...

  3. Gas identification field test based on FTIR imaging spectrometer (United States)

    Wang, Chensheng; Liu, Xingchao; Zhang, Zhijie; Yu, Hui


    Gas detection and identification is based on the spectral absorption peak feature, which is acquired by the spectrometer. FTIR imaging spectrometer has the advantages of high spectral resolution and good sensitivity, which are both suitable for the unknown or mixture gas identification applications, such as plume pollution monitoring, chemical agents detection and leakage detection. According to the application requirement, a dual band FTIR imaging spectrometer has been developed and verified. This FTIR imaging spectrometer combines the infrared thermal imaging sensor and Michelson interferometer to form the three dimensional data cube. Based on this instrument, the theoretical analysis and algorithm is introduced, and the numerical method is explained to illuminate the basic idea in gas identification based on spectral features. After that, the field verification test is setup and completed. Firstly, the FTIR imaging spectrometer is used to detect SF6, NH3 and the mixture gas, while the gas is exhausted out from the storage vase with a specific speed. Secondly, the instrument is delivered to the industrial area to monitor the plume emission, and analyze the components in plume. Finally, the instrument is utilized to monitoring the oil spill in ocean, and the practical maritime trial is realized. Further, the gas concentration evaluation method is discussed. Quantitative issue in gas identification is an important topic. The test results show that, based on the gas identification method introduced in this paper, FTIR imaging spectrometer can be utilized to identify the unknown gas or mixture gas in real time. The instrument will play a key role in environmental emergency and monitoring application.

  4. Near field ice detection using infrared based optical imaging technology (United States)

    Abdel-Moati, Hazem; Morris, Jonathan; Zeng, Yousheng; Corie, Martin Wesley; Yanni, Victor Garas


    If not detected and characterized, icebergs can potentially pose a hazard to oil and gas exploration, development and production operations in arctic environments as well as commercial shipping channels. In general, very large bergs are tracked and predicted using models or satellite imagery. Small and medium bergs are detectable using conventional marine radar. As icebergs decay they shed bergy bits and growlers, which are much smaller and more difficult to detect. Their low profile above the water surface, in addition to occasional relatively high seas, makes them invisible to conventional marine radar. Visual inspection is the most common method used to detect bergy bits and growlers, but the effectiveness of visual inspections is reduced by operator fatigue and low light conditions. The potential hazard from bergy bits and growlers is further increased by short detection range (<1 km). As such, there is a need for robust and autonomous near-field detection of such smaller icebergs. This paper presents a review of iceberg detection technology and explores applications for infrared imagers in the field. Preliminary experiments are performed and recommendations are made for future work, including a proposed imager design which would be suited for near field ice detection.

  5. Understanding sub-stellar populations using wide-field infrared surveys

    Directory of Open Access Journals (Sweden)

    Hewett P.C.


    Full Text Available This paper discusses benchmark brown dwarfs in various environments, and focuses on those in wide binary systems. We present a summary of the recently discovered T dwarf population from the UKIDSS Large Area Survey, and describe the constraints that it places on our knowledge of the sub-stellar initial mass function. We also present some exciting results from our ongoing search for wide companions to this sample, that has so far revealed an M4-T8.5 binary system at ∼12 parsecs and also the first ever Tdwarf-white dwarf binary system. The T dwarfs in these binaries have their properties constrained by the primary object and are thus benchmark objects that are already testing the predictions of theoretical model atmospheres.

  6. Electric field and temperature measurement using ultra wide bandwidth pigtailed electro-optic probes. (United States)

    Bernier, Maxime; Gaborit, Gwenaël; Duvillaret, Lionel; Paupert, Alain; Lasserre, Jean-Louis


    We present pigtailed electro-optic probes that allow a simultaneous measurement of high frequency electric fields and temperature using a unique laser probe beam. This has been achieved by the development of a novel probe design associated with a fully automated servo-controlled optical bench, initially developed to stabilize the electric field sensor response. The developed electro-optic probes present a stable response in outdoors conditions over a time duration exceeding 1 h, a frequency bandwidth from kHz to tens of GHz with a sensitivity of 0.7 Vm(-1)Hz(-(1/2)), and a temperature accuracy of 40 mK.

  7. Underwater Acoustic Matched Field Imaging Based on Compressed Sensing

    Directory of Open Access Journals (Sweden)

    Huichen Yan


    Full Text Available Matched field processing (MFP is an effective method for underwater target imaging and localizing, but its performance is not guaranteed due to the nonuniqueness and instability problems caused by the underdetermined essence of MFP. By exploiting the sparsity of the targets in an imaging area, this paper proposes a compressive sensing MFP (CS-MFP model from wave propagation theory by using randomly deployed sensors. In addition, the model’s recovery performance is investigated by exploring the lower bounds of the coherence parameter of the CS dictionary. Furthermore, this paper analyzes the robustness of CS-MFP with respect to the displacement of the sensors. Subsequently, a coherence-excluding coherence optimized orthogonal matching pursuit (CCOOMP algorithm is proposed to overcome the high coherent dictionary problem in special cases. Finally, some numerical experiments are provided to demonstrate the effectiveness of the proposed CS-MFP method.

  8. Real-time full field laser Doppler imaging (United States)

    Leutenegger, Marcel; Harbi, Pascal; Thacher, Tyler; Raffoul, Wassim; Lasser, Theo


    We present a full field laser Doppler imaging instrument that enables real-time in vivo assessment of blood flow in dermal tissue and skin. The instrument monitors the blood perfusion in an area of about 50cm2 with 480 × 480 pixels per frame at a rate of 12-14 frames per second. Smaller frames can be monitored at much higher frame rates. We recorded the microcirculation in healthy skin before, during and after arterial occlusion. In initial clinical case studies, we imaged the microcirculation in burned skin and monitored the recovery of blood flow in a skin flap during reconstructive surgery indicating the high potential of LDI for clinical applications.

  9. Full-field imaging of nonclassical acoustic nonlinearity (United States)

    Sarens, Bart; Kalogiannakis, Georgios; Glorieux, Christ; Van Hemelrijck, Danny


    The feasibility of full field shearographic detection of nonclassical acoustic nonlinearity is investigated. Traditional frequency analysis of the sinusoidally excited sample, as used in scanning techniques, turns out to be not practical due to the inherent optical detection nonlinearity of the shearography system itself. An alternative method, based on determining the asymmetry between shearographic images stroboscopically obtained for positive and negative displacements, is proposed. This approach allows us to easily and rapidly detect the tension-compression asymmetry which typically arises where nonbounded contact interface defects are present.

  10. Ultra-high field upper extremity peripheral nerve and non-contrast enhanced vascular imaging.

    Directory of Open Access Journals (Sweden)

    Shailesh B Raval

    Full Text Available The purpose of this study was to explore the efficacy of Ultra-high field [UHF] 7 Tesla [T] MRI as compared to 3T MRI in non-contrast enhanced [nCE] imaging of structural anatomy in the elbow, forearm, and hand [upper extremity].A wide range of sequences including T1 weighted [T1] volumetric interpolate breath-hold exam [VIBE], T2 weighted [T2] double-echo steady state [DESS], susceptibility weighted imaging [SWI], time-of-flight [TOF], diffusion tensor imaging [DTI], and diffusion spectrum imaging [DSI] were optimized and incorporated with a radiofrequency [RF] coil system composed of a transverse electromagnetic [TEM] transmit coil combined with an 8-channel receive-only array for 7T upper extremity [UE] imaging. In addition, Siemens optimized protocol/sequences were used on a 3T scanner and the resulting images from T1 VIBE and T2 DESS were compared to that obtained at 7T qualitatively and quantitatively [SWI was only qualitatively compared]. DSI studio was utilized to identify nerves based on analysis of diffusion weighted derived fractional anisotropy images. Images of forearm vasculature were extracted using a paint grow manual segmentation method based on MIPAV [Medical Image Processing, Analysis, and Visualization].High resolution and high quality signal-to-noise ratio [SNR] and contrast-to-noise ratio [CNR]-images of the hand, forearm, and elbow were acquired with nearly homogeneous 7T excitation. Measured [performed on the T1 VIBE and T2 DESS sequences] SNR and CNR values were almost doubled at 7T vs. 3T. Cartilage, synovial fluid and tendon structures could be seen with higher clarity in the 7T T1 and T2 weighted images. SWI allowed high resolution and better quality imaging of large and medium sized arteries and veins, capillary networks and arteriovenous anastomoses at 7T when compared to 3T. 7T diffusion weighted sequence [not performed at 3T] demonstrates that the forearm nerves are clearly delineated by fiber tractography. The

  11. Imaging and controlling plasmonic interference fields at buried interfaces (United States)

    Lummen, Tom T. A.; Lamb, Raymond J.; Berruto, Gabriele; Lagrange, Thomas; Dal Negro, Luca; García de Abajo, F. Javier; McGrouther, Damien; Barwick, B.; Carbone, F.


    Capturing and controlling plasmons at buried interfaces with nanometre and femtosecond resolution has yet to be achieved and is critical for next generation plasmonic devices. Here we use light to excite plasmonic interference patterns at a buried metal-dielectric interface in a nanostructured thin film. Plasmons are launched from a photoexcited array of nanocavities and their propagation is followed via photon-induced near-field electron microscopy (PINEM). The resulting movie directly captures the plasmon dynamics, allowing quantification of their group velocity at ~0.3 times the speed of light, consistent with our theoretical predictions. Furthermore, we show that the light polarization and nanocavity design can be tailored to shape transient plasmonic gratings at the nanoscale. This work, demonstrating dynamical imaging with PINEM, paves the way for the femtosecond and nanometre visualization and control of plasmonic fields in advanced heterostructures based on novel two-dimensional materials such as graphene, MoS2, and ultrathin metal films.

  12. Lensfree optofluidic plasmonic sensor for real-time and label-free monitoring of molecular binding events over a wide field-of-view (United States)

    Coskun, Ahmet F.; Cetin, Arif E.; Galarreta, Betty C.; Alvarez, Daniel Adrianzen; Altug, Hatice; Ozcan, Aydogan


    We demonstrate a high-throughput biosensing device that utilizes microfluidics based plasmonic microarrays incorporated with dual-color on-chip imaging toward real-time and label-free monitoring of biomolecular interactions over a wide field-of-view of >20 mm2. Weighing 40 grams with 8.8 cm in height, this biosensor utilizes an opto-electronic imager chip to record the diffraction patterns of plasmonic nanoapertures embedded within microfluidic channels, enabling real-time analyte exchange. This plasmonic chip is simultaneously illuminated by two different light-emitting-diodes that are spectrally located at the right and left sides of the plasmonic resonance mode, yielding two different diffraction patterns for each nanoaperture array. Refractive index changes of the medium surrounding the near-field of the nanostructures, e.g., due to molecular binding events, induce a frequency shift in the plasmonic modes of the nanoaperture array, causing a signal enhancement in one of the diffraction patterns while suppressing the other. Based on ratiometric analysis of these diffraction images acquired at the detector-array, we demonstrate the proof-of-concept of this biosensor by monitoring in real-time biomolecular interactions of protein A/G with immunoglobulin G (IgG) antibody. For high-throughput on-chip fabrication of these biosensors, we also introduce a deep ultra-violet lithography technique to simultaneously pattern thousands of plasmonic arrays in a cost-effective manner. PMID:25346102

  13. Wide range instantaneous temperature measurements of convective fluid flows by using a schlieren system based in color images (United States)

    Martínez-González, A.; Moreno-Hernández, D.; Monzón-Hernández, D.; León-Rodríguez, M.


    In the schlieren method, the deflection of light by the presence of an inhomogeneous medium is proportional to the gradient of its refractive index. Such deflection, in a schlieren system, is represented by light intensity variations on the observation plane. Then, for a digital camera, the intensity level registered by each pixel depends mainly on the variation of the medium refractive index and the status of the digital camera settings. Therefore, in this study, we regulate the intensity value of each pixel by controlling the camera settings such as exposure time, gamma and gain values in order to calibrate the image obtained to the actual temperature values of a particular medium. In our approach, we use a color digital camera. The images obtained with a color digital camera can be separated on three different color-channels. Each channel corresponds to red, green, and blue color, moreover, each one has its own sensitivity. The differences in sensitivity allow us to obtain a range of temperature values for each color channel. Thus, high, medium and low sensitivity correspond to green, blue, and red color channel respectively. Therefore, by adding up the temperature contribution of each color channel we obtain a wide range of temperature values. Hence, the basic idea in our approach to measure temperature, using a schlieren system, is to relate the intensity level of each pixel in a schlieren image to the corresponding knife-edge position measured at the exit focal plane of the system. Our approach was applied to the measurement of instantaneous temperature fields of the air convection caused by a heated rectangular metal plate and a candle flame. We found that for the metal plate temperature measurements only the green and blue color-channels were required to sense the entire phenomena. On the other hand, for the candle case, the three color-channels were needed to obtain a complete measurement of temperature. In our study, the candle temperature was took as

  14. A system perspective on designing for field-dependent SNR in wide-angle point-source detection lenses (United States)

    Olson, S. C.; Sparks, Andrew W.; Cline, Robert A.; Goodman, Timothy D.


    Lenses for staring-array point-source detection sensors must maintain good signal-to-noise ratio (SNR) over fields of view often exceeding 100 degrees. Such lenses typically have f-θ distortion to provide constant solid angle sampling in object space. While the relative illumination calculation is often used to describe flux transfer from a Lambertian extended object for imaging applications, maximizing SNR for point-source detection depends primarily on maximizing collected irradiance at the entrance pupil, the shape of which can vary dramatically over field. We illustrate this field-dependent SNR calculation with an example lens and outline the calculations needed to derive a simple aberration-based expression for the field dependence of point-source SNR.

  15. Influence of microlens array manufacturing errors on light-field imaging (United States)

    Li, Su-Ning; Yuan, Yuan; Liu, Bin; Wang, Fu-Qiang; Tan, He-Ping


    A microlens array (MLA) is a key optical element for four-dimensional light-field analysis in a light-field camera. MLA manufacturing errors affect light-field imaging, but their effects, especially on the physical imaging process and image-degradation mechanism, have not entirely been studied. In this paper, we develop a manufacturing-error model for MLA and quantitatively analyze raw images and refocused images using image quality evaluation indexes. The results indicate that manufacturing errors cause changes in image features including brightness, resolution, and spot position. The image-features undergo changes and the degree of degradation caused by different error types showed great differences.

  16. Optical System and Desing Of The New 1.6 Meter Wide-Field Telescope With Active Optics (United States)

    Papushev, Pavel; Denisenko, Sergey; Kamus, Sergey; Pimenov, Yury; Tergoev, Vladim


    In this report we present and discuss the design, construction and capabilities of the two meters class wide field survey telescope. The designs based on modified R-C system with two or three lens correctors in visible and near infrared (2,2 mkm) spectral range. The optical systems of the 1.6 meters telescope with up to 3 degrees field of view and less than 15% obscuration area are considered in detail. Optical performance of system, its mount and separate element of the active optics system are examined.

  17. All sky coordination initiative, simple service for wide-field monitoring systems to cooperate in searching for fast optical transients (United States)

    Karpov, S.; Sokołowski, M.; Gorbovskoy, E.

    Here we stress the necessity of cooperation between different wide-field monitoring projects (FAVOR/TORTORA, Pi of the Sky, MASTER, etc), aimed for independent detection of fast optical transients, in order to maximize the area of the sky covered at any moment and to coordinate the monitoring of gamma-ray telescopes' field of view. We review current solutions available for it and propose a simple protocol with dedicated service (ASCI) for such systems to share their current status and pointing schedules.

  18. Singapore National Medical Image Resource Centre (SN.MIRC): a world wide web resource for radiology education. (United States)

    Yang, Guo-Liang; Lim, C C Tchoyoson


    Radiology education is heavily dependent on visual images, and case-based teaching files comprising medical images can be an important tool for teaching diagnostic radiology. Currently, hardcopy film is being rapidly replaced by digital radiological images in teaching hospitals, and an electronic teaching file (ETF) library would be desirable. Furthermore, a repository of ETFs deployed on the World Wide Web has the potential for e-learning applications to benefit a larger community of learners. In this paper, we describe a Singapore National Medical Image Resource Centre (SN.MIRC) that can serve as a World Wide Web resource for teaching diagnostic radiology. On SN.MIRC, ETFs can be created using a variety of mechanisms including file upload and online form-filling, and users can search for cases using the Medical Image Resource Center (MIRC) query schema developed by the Radiological Society of North America (RSNA). The system can be improved with future enhancements, including multimedia interactive teaching files and distance learning for continuing professional development. However, significant challenges exist when exploring the potential of using the World Wide Web for radiology education.

  19. Crystal-field investigations of rare-earth-doped wide band gap semiconductors

    CERN Multimedia

    Muller, S; Wahl, U

    Crystal field investigations play a central role in the studies of rare earth doped semiconductors. Optical stark level spectroscopy and lattice location studies of radioactive rare earth isotopes implanted at ISOLDE have provided important insight into these systems during the last years. It has been shown that despite a major site preference of the probe atoms in the lattice, several defect configurations do exist. These sites are visible in the optical spectra but their origin and nature aren't deducible from these spectra alone. Hyperfine measurements on the other hand should reveal these defect configurations and yield the parameters necessary for a description of the optical properties at the atomic scale. In order to study the crystal field with this alternative approach, we propose a new concept for perturbed $\\gamma\\gamma$-angular correlation (PAC) experiments at ISOLDE based on digital signal processing in contrast to earlier analog setups. The general functionality of the spectrometer is explained ...

  20. Field Artillery in Combined Arms Maneuver and Wide Area Security Operations (United States)


    the laser guided 155mm 12 Copperhead and the 155mm Sense and Destroy Armor (SADARM) rounds.10 However, ranging the enemy was only one part of the...FA already had a PGM in the Copperhead and SADARM was still under development. Furthermore, the FA expanded the role of the MLRS by developing... Copperhead round obsolete. However, the FA continued to use the ATACMS and the GMLRS, and then fielded the GPS guided 155mm Excalibur round. The FA used

  1. Escape factors for thermionic cathodes in atomic gases in a wide electric field range (United States)

    Benilov, M. S.; Naidis, G. V.; Petrovic, Z. Lj; Radmilovic-Radjenovic, M.; Stojkovic, A.


    An approximate analytical expression is obtained for the escape factors for thermionically emitting cathodes in atomic gases that is uniformly valid at all values of the reduced electric field. This expression is used for evaluation of the escape factors in neon, helium and mercury. An independent evaluation is performed by means of Monte Carlo simulations. The analytical results are in good agreement with the results of Monte Carlo simulations, both for reflecting and non-reflecting cathodes.

  2. Escape factors for thermionic cathodes in atomic gases in a wide electric field range

    Energy Technology Data Exchange (ETDEWEB)

    Benilov, M S [Departamento de Fisica, Universidade da Madeira, Largo do MunicIpio, 9000 Funchal (Portugal); Naidis, G V [Institute for High Temperatures of the Russian Academy of Sciences, Izhorskaya 13/19, Moscow 125412 (Russian Federation); Petrovic, Z Lj [Institute of Physics, POB 68, 11080 Zemun, Belgrade (Serbia); Radmilovic-Radjenovic, M [Institute of Physics, POB 68, 11080 Zemun, Belgrade (Serbia); Stojkovic, A [Institute of Physics, POB 68, 11080 Zemun, Belgrade (Serbia)


    An approximate analytical expression is obtained for the escape factors for thermionically emitting cathodes in atomic gases that is uniformly valid at all values of the reduced electric field. This expression is used for evaluation of the escape factors in neon, helium and mercury. An independent evaluation is performed by means of Monte Carlo simulations. The analytical results are in good agreement with the results of Monte Carlo simulations, both for reflecting and non-reflecting cathodes.

  3. Design of refocusing system for a high-resolution space TDICCD camera with wide-field of view (United States)

    Lv, Shiliang; Liu, Jinguo


    This paper describes the design and realization of a refocusing system for a space TDICCD camera of 2.2-meter focal length, which, features a three mirror anastigmatic(TMA) optical system along with 8 TDICCDs assemble at the focal plane, is high resolution and wide field of view. TDICCDs assemble is a kind of major method of acquiring wide field of view for space camera. In this way, the swath width reach 60km. First, the design of TMA optical system and its advantage of this space TDICCD camera was introduced; Then, the refocusing system as well as the technique of mechanical interleaving assemble for TDICCDs focal plane of this space camera was discussed in detail, At last, the refocusing system was measured. Experimental results indicated that the precision of the refocusing system is +/- 3.12μm(3σ), which satisfy the refocusing control system requirements of higher precision and stabilization.

  4. Status and Perspectives of the Mini-MegaTORTORA Wide-field Monitoring System with High Temporal Resolution

    Directory of Open Access Journals (Sweden)

    Sergey Karpov


    Full Text Available Here we briefly summarize our long-term experience of constructing and operating wide-field monitoring cameras with sub-second temporal resolution to look for optical components of GRBs, fast-moving satellites and meteors. The general hardware requirements for these systems are discussed, along with algorithms for real-time detection and classification of various kinds of short optical transients. We also give a status report on the next generation, the MegaTORTORA multi-objective and transforming monitoring system, whose 6-channel (Mini-MegaTORTORA-Spain and 9-channel prototypes (Mini-MegaTORTORA-Kazan we have been building at SAO RAS. This system combines a wide field of view with subsecond temporal resolution in monitoring regime, and is able, within fractions of a second, to reconfigure itself to follow-up mode, which has better sensitivity and simultaneously provides multi-color and polarimetric information on detected transients.

  5. Mini-Mega-TORTORA wide-field monitoring system with sub-second temporal resolution: first year of operation (United States)

    Karpov, S.; Beskin, G.; Biryukov, A.; Bondar, S.; Ivanov, E.; Katkova, E.; Perkov, A.; Sasyuk, V.


    Here we present the summary of first years of operation and the first results of a novel 9-channel wide-field optical monitoring system with sub-second temporal resolution, Mini-Mega-TORTORA (MMT-9), which is in operation now at Special Astrophysical Observatory on Russian Caucasus. The system is able to observe the sky simultaneously in either wide (˜900 square degrees) or narrow (˜100 square degrees) fields of view, either in clear light or with any combination of color (Johnson-Cousins B, V or R) and polarimetric filters installed, with exposure times ranging from 0.1 s to hundreds of seconds. The real-time system data analysis pipeline performs automatic detection of rapid transient events, both near-Earth and extragalactic. The objects routinely detected by MMT include faint meteors and artificial satellites. The pipeline for a longer time scales variability analysis is still in development.

  6. A phase field method for joint denoising, edge detection, and motion estimation in image sequence processing

    NARCIS (Netherlands)

    Preusser, T.; Droske, M.; Garbe, C. S.; Telea, A.; Rumpf, M.


    The estimation of optical flow fields from image sequences is incorporated in a Mumford-Shah approach for image denoising and edge detection. Possibly noisy image sequences are considered as input and a piecewise smooth image intensity, a piecewise smooth motion field, and a joint discontinuity set

  7. Super-Resolution Far-Field Infrared Imaging by Photothermal Heterodyne Imaging. (United States)

    Li, Zhongming; Aleshire, Kyle; Kuno, Masaru; Hartland, Gregory V


    Infrared (IR) imaging provides chemical-specific information without the need for exogenous labels. Conventional far-field IR imaging techniques are diffraction limited, which means an effective spatial resolution of >5 μm with currently available optics. In this article, we present a novel far-field IR imaging technique based on photothermal heterodyne imaging (IR-PHI). In our version of IR-PHI, an IR pump laser excites the sample, causing a small temperature rise that is detected by a counterpropagating visible probe beam. Images and spectra of several different types of soft matter systems (polystyrene beads, thin polymer films, and single Escherichia coli bacterial cells) are presented to demonstrate the sensitivity and versatility of the technique. Importantly, the spatial resolution in the IR-PHI measurements is determined by the visible probe beam: a spatial resolution of 0.3 μm was achieved with a 0.53 μm probe wavelength and a high numerical aperture focusing objective. This is the highest spatial resolution reported to date for far-field IR imaging. Analysis of the experiments shows that for polymer beads in a dry environment, the magnitude of the IR-PHI signal is determined by the scattering cross section of the nano-object at the probe wavelength. This is in contrast to conventional PHI experiments in a heat-transfer medium, where the signal scales as the absorption cross section. This different scaling can be understood through the optical theorem. Our analysis also shows that both thermal expansion and changes in the refractive index of the material are important and that these two effects, in general, counteract each other.

  8. The Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) NASA Mission-of- Opportunity - Up and Operational (United States)

    McComas*, D. J.


    *Presented on behalf of the entire TWINS Team Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) is a NASA Explorer Mission-of-Opportunity to stereoscopically image the Earth's magnetosphere for the first time [McComas et al., 2008]. TWINS extends our understanding of magnetospheric structure and processes by providing simultaneous Energetic Neutral Atom (ENA) imaging from two widely separated locations. TWINS observes ENAs from 1-100 keV with high angular (~4° x 4°) and time (~1-minute) resolution. The TWINS Ly-α monitor measures the geocoronal hydrogen density to aid in ENA analysis while environmental sensors provide contemporaneous measurements of the local charged particle environments. By imaging ENAs with identical instruments from two widely spaced, high-altitude, high-inclination spacecraft, TWINS enables three-dimensional visualization of the large-scale structures and dynamics within the magnetosphere for the first time. As of the summer of 2008, both TWINS instruments are finally on orbit and operational and stereo imaging of the magnetosphere has begun. This talk briefly summarizes the TWINS mission and instruments and shows some of the 'first-light' observations. More information about TWINS and access to these data are available at Reference: McComas, D.J., F. Allegrini, J. Baldonado, B. Blake, P. C. Brandt, J. Burch, J. Clemmons, W. Crain, D. Delapp, R. DeMajistre, D. Everett, H. Fahr, L. Friesen, H. Funsten, J. Goldstein, M. Gruntman, R. Harbaugh, R. Harper, H. Henkel, C. Holmlund, G. Lay, D. Mabry, D. Mitchell, U. Nass, C. Pollock, S. Pope, M. Reno, S. Ritzau, E. Roelof, E. Scime, M. Sivjee, R. Skoug, T. S. Sotirelis, M. Thomsen, C. Urdiales, P. Valek, K. Viherkanto, S. Weidner, T. Ylikorpi, M. Young, J. Zoennchen, The Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) NASA Mission-of-Opportunity, Submitted to Space Science Reviews, 2008.

  9. Obtaining Sub-uas Astrometry on a Wide-field, Coronagraph Equipped, Space Telescope Using a Diffractive Pupil (United States)

    Bendek, Eduardo; Belikov, R.; Guyon, O.


    Detection and mass measurement of earth-size exoplanets using the astrometric signal of the host star requires sub-uas measurement precision. One major challenge in achieving this precision using medium-size space telescopes is the calibration of dynamic distortions. To solve this problem, we propose a diffractive pupil approach in which an array of dots on the primary mirror generates polychromatic diffraction spikes in the focal plane used to calibrate the distortions in the optical system. According to our simulations, this technique enables 0.2microarcsecond or better single-visit precision astrometric measurements on a 2.4m wide-field (>0.1deg2) space telescope. We present the laboratory results of the diffractive pupil concept performed at the University of Arizona, showing that this approach can calibrate dynamic distortion errors even for wide field applications. Also, this technique can be used simultaneously with a high-performance coronagraph to determine/constrain the masses, composition, atmospheric properties, and planetary system architectures. Numerical simulations and experiments performed at the NASA Ames ACE test bed have shown that the diffractive pupil does not affect the coronagraph performance. Finally, we assess the compatibility of a diffractive pupil telescope with a general astrophysics mission, showing that the spikes are too faint to impact wide field observations.

  10. Wide-Field Survey around Local Group Dwarf Spheroidal Galaxy Leo II: Spatial Distribution of Stellar Content (United States)

    Komiyama, Yutaka; Doi, Mamoru; Furusawa, Hisanori; Hamabe, Masaru; Imi, Katsumi; Kimura, Masahiko; Miyazaki, Satoshi; Nakata, Fumiaki; Okada, Norio; Okamura, Sadanori; Ouchi, Masami; Sekiguchi, Maki; Shimasaku, Kazuhiro; Yagi, Masafumi; Yasuda, Naoki


    We carried out a wide-field V, I imaging survey of the Local Group dwarf spheroidal galaxy Leo II using the Subaru Prime Focus Camera on the 8.2 m Subaru Telescope. The survey covered an area of 26.67×26.67 arcmin2, far beyond the tidal radius of Leo II (8.63'), down to the limiting magnitude of V~=26, which is roughly 1 mag deeper than the turnoff point of the main-sequence stars of Leo II. Radial number density profiles of bright and faint red giant branch (RGB) stars were found to change their slopes at around the tidal radius, and extend beyond the tidal radius with shallower slopes. A smoothed surface brightness map of Leo II suggests the existence of a small substructure (4×2.5 arcmin2, 270×170 pc 2 in physical size) of globular cluster luminosity beyond the tidal radius. We investigated the properties of the stellar population by means of a color-magnitude diagram. The horizontal branch (HB) morphology index shows a radial gradient in which red HB stars are more concentrated than blue HB stars, which is common to many Local Group dwarf spheroidal galaxies. The color distribution of RGB stars around the mean RGB sequence shows a larger dispersion at the center than in the outskirts, indicating a mixture of stellar populations at the center and a more homogeneous population in the outskirts. Based on the age estimation using subgiant branch stars, we found that although the major star formation took place ~8 Gyr ago, a considerable stellar population younger than 8 Gyr is found at the center; such a younger population is insignificant in the outskirts. The following star formation history is suggested for Leo II. Star-forming activity occurred more than ~8 Gyr ago throughout the galaxy at a modest star formation rate. The star-forming region gradually shrank from the outside toward the center, and star-forming activity finally dropped to ~0 by ~4 Gyr ago, except for the center, where a small population younger than 4 Gyr is present. Based on data collected

  11. Narcissus analysis of cooled IR optical system with multi-magnification in wide field of view (United States)

    Hong, Jinsuk; Kim, Youngsoo


    The designed Infra-red optical system with multi-magnification shows non-uniform thermal distribution only in Wide FOV and suspected to be narcissus effect. To analyze the system's artifacts more effectively, the optical system design was imported to analysis codes. Initial ray tracing was performed with a point source from the detector to identify main candidates of Narcissus effect by analyzing irradiance distribution and flux distribution. As a second step, a planer source was created at the detector and traced again. As a result, four major candidates were selected and the major contributor was identified among them. To confirm the result with experiment, replacement optical component was manufactured. We can confirm that the Narcissus effect was improved significantly by replacing the identified component.

  12. Image-based Exploration of Large-Scale Pathline Fields

    KAUST Repository

    Nagoor, Omniah H.


    While real-time applications are nowadays routinely used in visualizing large nu- merical simulations and volumes, handling these large-scale datasets requires high-end graphics clusters or supercomputers to process and visualize them. However, not all users have access to powerful clusters. Therefore, it is challenging to come up with a visualization approach that provides insight to large-scale datasets on a single com- puter. Explorable images (EI) is one of the methods that allows users to handle large data on a single workstation. Although it is a view-dependent method, it combines both exploration and modification of visual aspects without re-accessing the original huge data. In this thesis, we propose a novel image-based method that applies the concept of EI in visualizing large flow-field pathlines data. The goal of our work is to provide an optimized image-based method, which scales well with the dataset size. Our approach is based on constructing a per-pixel linked list data structure in which each pixel contains a list of pathlines segments. With this view-dependent method it is possible to filter, color-code and explore large-scale flow data in real-time. In addition, optimization techniques such as early-ray termination and deferred shading are applied, which further improves the performance and scalability of our approach.

  13. From Widely Accepted Concepts in Coordination Chemistry to Inverted Ligand Fields. (United States)

    Hoffmann, Roald; Alvarez, Santiago; Mealli, Carlo; Falceto, Andrés; Cahill, Thomas J; Zeng, Tao; Manca, Gabriele


    We begin with a brief historical review of the development of our understanding of the normal ordering of nd orbitals of a transition metal interacting with ligands, the most common cases being three below two in an octahedral environment, two below three in tetrahedral coordination, and four below one in a square-planar environment. From the molecular orbital construction of these ligand field splittings evolves a strategy for inverting the normal order: the obvious way to achieve this is to raise the ligand levels above the metal d's; that is, make the ligands better Lewis bases. However, things are not so simple, for such metal/ligand level placement may lead to redox processes. For 18-electron octahedral complexes one can create the inverted situation, but it manifests itself in the makeup of valence orbitals (are they mainly on metal or ligands?) rather than energy. One can also see the effect, in small ways, in tetrahedral Zn(II) complexes. We construct several examples of inverted ligand field systems with a hypothetical but not unrealistic AlCH3 ligand and sketch the consequences of inversion on reactivity. Special attention is paid to the square-planar case, exemplified by [Cu(CF3)4](-), in which Snyder had the foresight to see a case of an inverted field, with the empty valence orbital being primarily ligand centered, the dx2-y2 orbital heavily occupied, in what would normally be called a Cu(III) complex. For [Cu(CF3)4](-) we provide theoretical evidence from electron distributions, geometry of the ligands, thermochemistry of molecule formation, and the energetics of abstraction of a CF3 ligand by a base, all consistent with oxidation of the ligands in this molecule. In [Cu(CF3)4](-), and perhaps more complexes on the right side of the transition series than one has imagined, some ligands are σ-noninnocent. Exploration of inverted ligand fields helps us see the continuous, borderless transition from transition metal to main group bonding. We also give

  14. Development, Demonstration, and Field Testing of Enterprise-Wide Distributed Generation Energy Management System: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Greenberg, S.; Cooley, C.


    This report details progress on subcontract NAD-1-30605-1 between the National Renewable Energy Laboratory and RealEnergy (RE), the purpose of which is to describe RE's approach to the challenges it faces in the implementation of a nationwide fleet of clean cogeneration systems to serve contemporary energy markets. The Phase 2 report covers: utility tariff risk and its impact on market development; the effect on incentives on distributed energy markets; the regulatory effectiveness of interconnection in California; a survey of practical field interconnection issues; trend analysis for on-site generation; performance of dispatch systems; and information design hierarchy for combined heat and power.

  15. A Wide-angle Multi-Octave Broadband Waveplate Based on Field Transformation Approach. (United States)

    Zhao, Junming; Zhang, Lianhong; Li, Jensen; Feng, Yijun; Dyke, Amy; Haq, Sajad; Hao, Yang


    Transformation optics (TO) offers a geometrical approach in designing optical components of any shapes. Although it has been proven to be a versatile and robust mathematical tool, TO has, however, limited control over electromagnetic (EM) field polarization in the process of coordinate transformation. Such a technique can be extended to a so-called "Field transformation (FT)" which provides direct control over the impedance and polarization signature of an arbitrary object. In this work, we demonstrate a FT application by designing and manufacturing a novel waveplate, which defies the fundamental limit of bandwidth and incident angles and has the ability of converting between TE (transverse electric) and TM (transverse magnetic) as well as LCP (left-handed circular polarization) and RCP (right-handed circular polarization). Such a waveplate can also be applied to different operating modes for both transmitted and reflected waves by adjusting its thickness and adding an optional metallic ground plane. The proposed design approach presents a remarkable degree of advance for designing future devices with arbitrary polarization controls, artificial waveguides or antenna substrates and polarization-enabled resonators with angle-insensitive functionalities. Our approach has far reaching implications applicable from radio to optical frequencies.

  16. Full-parallax virtual view image synthesis using image-based rendering for light-field content generation (United States)

    Park, Youngsoo; Shin, Hong-chang; Lee, Gwangsoon; Cheong, Won-sik; Hur, Namho


    Light-field content is required to provide full-parallax 3D view with dense angular resolution. However, it is very hard to directly capture such dense full-parallax view images using a camera system because it requires specialised micro-lens arrays or a heavy camera-array system. Therefore, we present an algorithm to synthesise full-parallax virtual view images using image-based rendering appropriate for light-field content generation. The proposed algorithm consists of four-directional image warping, view image blending using the nearest view image priority selection and the sum of the weighted inverse Euclidean distance, and hole filling. Experimental results show that dense full-parallax virtual view images can be generated from sparse full-parallax view images with fewer image artefacts. Finally, it is confirmed that the proposed full-parallax view synthesis algorithm can be used for light-field content generation without a dense camera array system.


    Energy Technology Data Exchange (ETDEWEB)

    Brammer, Gabriel B. [European Southern Observatory, Alonso de Cordova 3107, Casilla 19001, Vitacura, Santiago (Chile); Van Dokkum, Pieter G.; Skelton, Rosalind E.; Nelson, Erica; Bezanson, Rachel; Leja, Joel; Lundgren, Britt [Department of Astronomy, Yale University, New Haven, CT 06520 (United States); Franx, Marijn; Fumagalli, Mattia; Patel, Shannon; Labbe, Ivo [Leiden Observatory, Leiden University, Leiden (Netherlands); Rix, Hans-Walter; Schmidt, Kasper B.; Da Cunha, Elisabete [Max Planck Institute for Astronomy (MPIA), Koenigstuhl 17, 69117 Heidelberg (Germany); Kriek, Mariska [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Erb, Dawn K. [Department of Physics, University of Wisconsin-Milwaukee, P.O. Box 413, Milwaukee, WI 53201 (United States); Fan, Xiaohui [Steward Observatory, University of Arizona, Tucson, AZ 85721 (United States); Foerster Schreiber, Natascha [Max-Planck-Institut fuer Extraterrestrische Physik, Giessenbachstrasse, D-85748 Garching (Germany); Illingworth, Garth D.; Magee, Dan, E-mail: [Astronomy Department, University of California, Santa Cruz, CA 95064 (United States); and others


    We present 3D-HST, a near-infrared spectroscopic Treasury program with the Hubble Space Telescope for studying the physical processes that shape galaxies in the distant universe. 3D-HST provides rest-frame optical spectra for a sample of {approx}7000 galaxies at 1 < z < 3.5, the epoch when {approx}60% of all star formation took place, the number density of quasars peaked, the first galaxies stopped forming stars, and the structural regularity that we see in galaxies today must have emerged. 3D-HST will cover three quarters (625 arcmin{sup 2}) of the CANDELS Treasury survey area with two orbits of primary WFC3/G141 grism coverage and two to four orbits with the ACS/G800L grism in parallel. In the IR, these exposure times yield a continuum signal-to-noise ratio of {approx}5 per resolution element at H{sub 140} {approx} 23.1 and a 5{sigma} emission-line sensitivity of {approx}5 Multiplication-Sign 10{sup -17} erg s{sup -1} cm{sup -2} for typical objects, improving by a factor of {approx}2 for compact sources in images with low sky background levels. The WFC3/G141 spectra provide continuous wavelength coverage from 1.1 to 1.6 {mu}m at a spatial resolution of {approx}0.''13, which, combined with their depth, makes them a unique resource for studying galaxy evolution. We present an overview of the preliminary reduction and analysis of the grism observations, including emission-line and redshift measurements from combined fits to the extracted grism spectra and photometry from ancillary multi-wavelength catalogs. The present analysis yields redshift estimates with a precision of {sigma}(z) = 0.0034(1 + z), or {sigma}(v) Almost-Equal-To 1000 km s{sup -1}. We illustrate how the generalized nature of the survey yields near-infrared spectra of remarkable quality for many different types of objects, including a quasar at z = 4.7, quiescent galaxies at z {approx} 2, and the most distant T-type brown dwarf star known. The combination of the CANDELS and 3D-HST surveys

  18. Convolutional virtual electric field for image segmentation using active contours.

    Directory of Open Access Journals (Sweden)

    Yuanquan Wang

    Full Text Available Gradient vector flow (GVF is an effective external force for active contours; however, it suffers from heavy computation load. The virtual electric field (VEF model, which can be implemented in real time using fast Fourier transform (FFT, has been proposed later as a remedy for the GVF model. In this work, we present an extension of the VEF model, which is referred to as CONvolutional Virtual Electric Field, CONVEF for short. This proposed CONVEF model takes the VEF model as a convolution operation and employs a modified distance in the convolution kernel. The CONVEF model is also closely related to the vector field convolution (VFC model. Compared with the GVF, VEF and VFC models, the CONVEF model possesses not only some desirable properties of these models, such as enlarged capture range, u-shape concavity convergence, subject contour convergence and initialization insensitivity, but also some other interesting properties such as G-shape concavity convergence, neighboring objects separation, and noise suppression and simultaneously weak edge preserving. Meanwhile, the CONVEF model can also be implemented in real-time by using FFT. Experimental results illustrate these advantages of the CONVEF model on both synthetic and natural images.

  19. Small Airborne Hyperspectral Wide Area Imager for Disaster Response and Earth Science Project (United States)

    National Aeronautics and Space Administration — The proposed hyperspectral plus LWIR system will deliver high signal to noise performance, a wide spectral range, nominally 365 nm to 1.7 um, a single long wave IR...

  20. Microwave power imaging for ultra-wide band early breast cancer detection (United States)

    Shao, Wenyi

    Due to the critical need for complementary or/and alternative modalities to current X-ray mammography for early-stage breast cancer detection, a 3D active microwave imaging system has been developed. This thesis presents a detailed method for rapid, high contrast microwave imaging for the purpose of breast survey. In the proposed imaging system, several transmitters polarized in different directions take turns sending out a low-power UWB pulse into the breast; backscattered signals are recorded by a synthetic aperture antenna array. These backscattered signals are passed through a beamformer, which spatially focuses the waveforms to image backscattered energy as a function of location in the breast. A simple Delay-and-Sum algorithm is applied to test the proposed multistatic multi-polarized detection scheme. The obtained 2-D and 3-D numerical results have demonstrated the feasibility and superiority of detecting small malignant breast tumors using our antenna strategy. An improved algorithm of microwave power imaging for detecting small breast tumors within an MRI-derived phantom is also introduced. Our imaging results demonstrate that a high-quality image can be reached without solving the inverse problem. To set up an experimental system for future clinical investigation, we developed two Vivaldi antennas, which have a notable broad band property, good radiation pattern, and a suitable size for breast cancer detection. Finally, an antenna array which consists of eight proposed Vivaldi antennas is introduced. By conveniently moving up/down and rotating this antenna array, it can be used for the multistatic breast cancer imaging and qualified for our multi-polarized scan mode.

  1. Theory of Superthermal, Wide, Electron Phase-Space Holes and Bipolar Fields* (United States)

    Goldman, M. V.; Newman, D. L.


    Laboratory reconnection experiments [1] and recent magnetospheric spacecraft observations [2] are beginning to find bipolar fields with a spatial half-width equal to many Debye lengths (10 or more) traveling at high speeds (faster than the thermal velocity of the bulk of electrons). Electron phase-space hole solutions of the nonlinear Poisson-Vlasov equations (stationary in a frame co-moving with the hole) are constructed analytically with these properties by assuming there is secondary component of the electron distribution. This component can be a tail on the electron distribution or a beam. The hole velocity will be close to the velocity at the end of the tail or the velocity of the beam, provided the ions are moving with sufficient velocity in the frame of the hole. Vlasov simulations are used to study accessibility and stability of these solutions. * Work supported by DOE, NASA, and NSF [1]W. Fox, M. Porkolab, J. Egedal, N. Katz, A. Le, and A. Vrublevskis, "Observation of electron phase-space holes during magnetic reconnection in the Versatile Toroidal Facility," Abstract GP6.00029, 50th Annual Meeting of the Division of Plasma Physics, American Physical Society (Dallas, Nov.~2008). [2] R. E. Ergun and J. Tao, private communication.

  2. New Material Transistor with Record-High Field-Effect Mobility among Wide-Band-Gap Semiconductors. (United States)

    Shih, Cheng Wei; Chin, Albert


    At an ultrathin 5 nm, we report a new high-mobility tin oxide (SnO2) metal-oxide-semiconductor field-effect transistor (MOSFET) exhibiting extremely high field-effect mobility values of 279 and 255 cm(2)/V-s at 145 and 205 °C, respectively. These values are the highest reported mobility values among all wide-band-gap semiconductors of GaN, SiC, and metal-oxide MOSFETs, and they also exceed those of silicon devices at the aforementioned elevated temperatures. For the first time among existing semiconductor transistors, a new device physical phenomenon of a higher mobility value was measured at 45-205 °C than at 25 °C, which is due to the lower optical phonon scattering by the large SnO2 phonon energy. Moreover, the high on-current/off-current of 4 × 10(6) and the positive threshold voltage of 0.14 V at 25 °C are significantly better than those of a graphene transistor. This wide-band-gap SnO2 MOSFET exhibits high mobility in a 25-205 °C temperature range, a wide operating voltage of 1.5-20 V, and the ability to form on an amorphous substrate, rendering it an ideal candidate for multifunctional low-power integrated circuit (IC), display, and brain-mimicking three-dimensional IC applications.

  3. Wide area coverage radar imaging satellite for earth applications. [surveillance and mapping of ice on Great Lakes (United States)

    Stevens, G. H.; Ramler, J. R.


    A preliminary study was made of a radar imaging satellite for earth applications. A side-looking synthetic-aperture radar was considered and the feasibility of obtaining a wide area coverage to reduce the time required to image a given area was investigated. Two basic approaches were examined; low altitude sun-synchronous orbits using a multibeam/multifrequency radar system and equatorial orbits up to near-synchronous altitude using a single beam system. Surveillance and mapping of ice on the Great Lakes was used as a typical application to focus the study effort.

  4. Object-based image analysis for scaling properties of rangeland ecosystems: Linking field and image data for management decision making (United States)

    Karl, Jason William

    Management of semi-arid shrub-steppe ecosystems (i.e., rangelands) requires accurate information over large landscapes, and remote sensing is an attractive option for collecting such data. To successfully use remotely-sensed data in landscape-level rangeland management, questions as to the relevance of image data to landscape patterns and optimal scales of analysis must be addressed. Object-based image analysis (OBIA), which segments image pixels into homogeneous regions, or objects, has been suggested as a way to increase accuracy of remotely-sensed products, but little research has gone into how to determine sizes of image objects with regard to scaling of ecosystem properties. The purpose of my dissertation was to determine if OBIA could be used to generate observational scales to match ecological scales in rangelands and to explore the potential for OBIA to generate accurate and repeatable remote-sensing products for managers. The work presented here was conducted in southern Idaho's Snake River Plain region. By comparing OBIA segmentation of satellite imagery into successively coarser objects to pixel-based aggregation methods, I found that canonical correlations between field-collected and image data were similar at the finest scales, but higher for image segmentation as scale increased. I also detected scaling thresholds with image segmentation that were confirmed via semi-variograms of field data. This approach proved useful for evaluating the overall utility of an image to address an objective, and identifying scaling limits for analysis. I next used observations of percent bare-ground cover from 346 field sites to consider how hierarchies of image objects created through OBIA could be used to discover appropriate scales for analysis given a specific objective. Using a regression-based approach, I found that segmentation levels whose predictions of bare-ground cover had spatial dependence that most closely matched the spatial dependence of the field

  5. Wide-Field Hubble Space Telescope Observations of the Globular Cluster System in NGC 1399* (United States)

    Puzia, Thomas H.; Paolillo, Maurizio; Goudfrooij, Paul; Maccarone, Thomas J.; Fabbiano, Giuseppina; Angelini, Lorella


    We present a comprehensive high spatial resolution imaging study of globular clusters (GCs) in NGC 1399, thecentral giant elliptical cD galaxy in the Fornax galaxy cluster, conducted with the Advanced Camera for Surveys(ACS) aboard theHubble Space Telescope(HST).Using a novel technique to construct drizzled point-spreadfunction libraries for HSTACS data, we accurately determine the fidelity of GC structural parameter measurementsfrom detailed artificial star cluster experiments and show the superior robustness of the GC half-light radius,rh,compared with other GC structural parameters, such as King core and tidal radius. The measurement ofrhfor themajor fraction of the NGC 1399 GC system reveals a trend of increasingrhversus galactocentric distance,Rgal,out to about 10 kpc and a flat relation beyond. This trend is very similar for blue and red GCs, which are found tohave a mean size ratio ofrh,redrh,blue0.820.11 at all galactocentric radii from the core regions of the galaxyout to40 kpc. This suggests that the size difference between blue and red GCs is due to internal mechanismsrelated to the evolution of their constituent stellar populations. Modeling the mass density profile of NGC 1399shows that additional external dynamical mechanisms are required to limit the GC size in the galaxy halo regionstorh2 pc. We suggest that this may be realized by an exotic GC orbit distribution function, an extended darkmatter halo, andor tidal stress induced by the increased stochasticity in the dwarf halo substructure at largergalactocentric distances. We compare our results with the GCrhdistribution functions in various galaxies and findthat the fraction of extended GCs withrh5 pc is systematically larger in late-type galaxies compared with GCsystems in early-type galaxies. This is likely due to the dynamically more violent evolution of early-type galaxies.We match our GCrhmeasurements with radial velocity data from the literature and split the resulting sample at

  6. Quantifying fire-wide carbon emissions in interior Alaska using field measurements and Landsat imagery (United States)

    Rogers, B. M.; Veraverbeke, S.; Azzari, G.; Czimczik, C. I.; Holden, S. R.; Mouteva, G. O.; Sedano, F.; Treseder, K. K.; Randerson, J. T.


    Carbon emissions from boreal forest fires are projected to increase with continued warming and constitute a potentially significant positive feedback to climate change. The highest consistent combustion levels are reported in interior Alaska and can be highly variable depending on the consumption of soil organic matter. Here we present an approach for quantifying emissions within a fire perimeter using remote sensing of fire severity. Combustion from belowground and aboveground pools was quantified at 22 sites (17 black spruce and five white spruce-aspen) within the 2010 Gilles Creek burn in interior Alaska, constrained by data from eight unburned sites. We applied allometric equations and estimates of consumption to calculate carbon losses from aboveground vegetation. The position of adventitious spruce roots within the soil column, together with estimated prefire bulk density and carbon concentrations, was used to quantify belowground combustion. The differenced Normalized Burn Ratio (dNBR) exhibited a clear but nonlinear relationship with combustion that differed by forest type. We used a multiple regression model based on transformed dNBR and deciduous fraction to scale carbon emissions to the fire perimeter, and a Monte Carlo framework to assess uncertainty. Because of low-severity and unburned patches, mean combustion across the fire perimeter (1.98 ± 0.34 kg C m-2) was considerably less than within a defined core burn area (2.67 ± 0.40 kg C m-2) and the mean at field sites (2.88 ± 0.23 kg C m-2). These areas constitute a significant fraction of burn perimeters in Alaska but are generally not accounted for in regional-scale estimates. Although total combustion in black spruce was slightly lower than in white spruce-aspen forests, black spruce covered most of the fire perimeter (62%) and contributed the majority (67 ± 16%) of total emissions. Increases in spring albedo were found to be a viable alternative to dNBR for modeling emissions.

  7. Prototype phantoms for characterization of ultralow field magnetic resonance imaging. (United States)

    Boss, Michael A; Mates, John A B; Busch, Sarah E; SanGiorgio, Paul; Russek, Stephen E; Buckenmaier, Kai; Irwin, Kent D; Cho, Hsiao-Mei; Hilton, Gene C; Clarke, John


    Prototype phantoms were designed, constructed, and characterized for the purpose of calibrating ultralow field magnetic resonance imaging (ULF MRI) systems. The phantoms were designed to measure spatial resolution and to quantify sensitivity to systematic variation of proton density and relaxation time, T1 . The phantoms were characterized first with conventional magnetic resonance scanners at 1.5 and 3 T, and subsequently with a prototype ULF MRI scanner between 107 and 128 μT . The ULF system demonstrated a 2-mm spatial resolution and, using T1 measurements, distinguished aqueous solutions of MnCl2 differing by 20 μM  [Mn(2+) ]. The prototype phantoms proved well-matched to ULF MRI applications, and allowed direct comparison of the performance of ULF and clinical systems. © 2013 Wiley Periodicals, Inc.

  8. Quantum Field Theory as a Faithful Image of Nature

    CERN Document Server

    Öttinger, Hans Christian


    "All men by nature desire to know," states Aristotle in the famous first sentence of his Metaphysics. Knowledge about fundamental particles and interactions, that is, knowledge about the deepest aspects of matter, is certainly high if not top on the priority list, not only for physicists and philosophers. The goal of the present book is to contribute to this knowledge by going beyond the usual presentations of quantum field theory in physics textbooks, both in mathematical approach and by critical reflections inspired by epistemology, that is, by the branch of philosophy also referred to as the theory of knowledge. Hopefully, the present book motivates physicists to appreciate philosophical ideas. Epistemology and the philosophy of the evolution of science often seem to lag behind science and to describe the developments a posteriori. As philosophy here has a profound influence on the actual shaping of an image of fundamental particles and their interactions, our development should stimulate the curiosity and...

  9. WE-G-18C-05: Characterization of Cross-Vendor, Cross-Field Strength MR Image Intensity Variations

    Energy Technology Data Exchange (ETDEWEB)

    Paulson, E; Prah, D [Medical College of Wisconsin, Milwaukee, WI (United States)


    Purpose: Variations in MR image intensity and image intensity nonuniformity (IINU) can challenge the accuracy of intensity-based image segmentation and registration algorithms commonly applied in radiotherapy. The goal of this work was to characterize MR image intensity variations across scanner vendors and field strengths commonly used in radiotherapy. Methods: ACR-MRI phantom images were acquired at 1.5T and 3.0T on GE (450w and 750, 23.1), Siemens (Espree and Verio, VB17B), and Philips (Ingenia, 4.1.3) scanners using commercial spin-echo sequences with matched parameters (TE/TR: 20/500 ms, rBW: 62.5 kHz, TH/skip: 5/5mm). Two radiofrequency (RF) coil combinations were used for each scanner: body coil alone, and combined body and phased-array head coils. Vendorspecific B1- corrections (PURE/Pre-Scan Normalize/CLEAR) were applied in all head coil cases. Images were transferred offline, corrected for IINU using the MNI N3 algorithm, and normalized. Coefficients of variation (CV=σ/μ) and peak image uniformity (PIU = 1−(Smax−Smin)/(Smax+Smin)) estimates were calculated for one homogeneous phantom slice. Kruskal-Wallis and Wilcoxon matched-pairs tests compared mean MR signal intensities and differences between original and N3 image CV and PIU. Results: Wide variations in both MR image intensity and IINU were observed across scanner vendors, field strengths, and RF coil configurations. Applying the MNI N3 correction for IINU resulted in significant improvements in both CV and PIU (p=0.0115, p=0.0235). However, wide variations in overall image intensity persisted, requiring image normalization to improve consistency across vendors, field strengths, and RF coils. These results indicate that B1- correction routines alone may be insufficient in compensating for IINU and image scaling, warranting additional corrections prior to use of MR images in radiotherapy. Conclusions: MR image intensities and IINU vary as a function of scanner vendor, field strength, and RF coil

  10. Orientational imaging of a single plasmonic nanoparticle using dark-field hyperspectral imaging (United States)

    Mehta, Nishir; Mahigir, Amirreza; Veronis, Georgios; Gartia, Manas Ranjan


    Orientation of plasmonic nanostructures is an important feature in many nanoscale applications such as catalyst, biosensors DNA interactions, protein detections, hotspot of surface enhanced Raman spectroscopy (SERS), and fluorescence resonant energy transfer (FRET) experiments. However, due to diffraction limit, it is challenging to obtain the exact orientation of the nanostructure using standard optical microscope. Hyperspectral Imaging Microscopy is a state-of-the-art visualization technology that combines modern optics with hyperspectral imaging and computer system to provide the identification and quantitative spectral analysis of nano- and microscale structures. In this work, initially we use transmitted dark field imaging technique to locate single nanoparticle on a glass substrate. Then we employ hyperspectral imaging technique at the same spot to investigate orientation of single nanoparticle. No special tagging or staining of nanoparticle has been done, as more likely required in traditional microscopy techniques. Different orientations have been identified by carefully understanding and calibrating shift in spectral response from each different orientations of similar sized nanoparticles. Wavelengths recorded are between 300 nm to 900 nm. The orientations measured by hyperspectral microscopy was validated using finite difference time domain (FDTD) electrodynamics calculations and scanning electron microscopy (SEM) analysis. The combination of high resolution nanometer-scale imaging techniques and the modern numerical modeling capacities thus enables a meaningful advance in our knowledge of manipulating and fabricating shaped nanostructures. This work will advance our understanding of the behavior of small nanoparticle clusters useful for sensing, nanomedicine, and surface sciences.

  11. Distortion-free magnetic resonance imaging in the zero-field limit

    Energy Technology Data Exchange (ETDEWEB)

    Kelso, Nathan; Lee, Seung-Kyun; Bouchard, Louis-S.; Demas, Vasiliki; Muck, Michael; Pines, Alexander; Clarke, John


    MRI is a powerful technique for clinical diagnosis and materials characterization. Images are acquired in a homogeneous static magnetic field much higher than the fields generated across the field of view by the spatially encoding field gradients. Without such a high field, the concomitant components of the field gradient dictated by Maxwell's equations lead to severe distortions that make imaging impossible with conventional MRI encoding. In this paper, we present a distortion-free image of a phantom acquired with a fundamentally different methodology in which the applied static field approaches zero. Our technique involves encoding with pulses of uniform and gradient field, and acquiring the magnetic field signals with a SQUID. The method can be extended to weak ambient fields, potentially enabling imaging in the Earth's field without cancellation coils or shielding. Other potential applications include quantum information processing and fundamental studies of long-range ferromagnetic interactions.

  12. Dark field imaging system for size characterization of magnetic micromarkers (United States)

    Malec, A.; Haiden, C.; Kokkinis, G.; Keplinger, F.; Giouroudi, I.


    In this paper we demonstrate a dark field video imaging system for the detection and size characterization of individual magnetic micromarkers suspended in liquid and the detection of pathogens utilizing magnetically labelled E.coli. The system follows dynamic processes and interactions of moving micro/nano objects close to or below the optical resolution limit, and is especially suitable for small sample volumes ( 10 μl). The developed detection method can be used to obtain clinical information about liquid contents when an additional biological protocol is provided, i.e., binding of microorganisms (e.g. E.coli) to specific magnetic markers. Some of the major advantages of our method are the increased sizing precision in the micro- and nano-range as well as the setup's simplicity making it a perfect candidate for miniaturized devices. Measurements can thus be carried out in a quick, inexpensive, and compact manner. A minor limitation is that the concentration range of micromarkers in a liquid sample needs to be adjusted in such a manner that the number of individual particles in the microscope's field of view is sufficient.

  13. Surgical feasibility and biocompatibility of wide-field dual-array suprachoroidal-transretinal stimulation prosthesis in middle-sized animals. (United States)

    Lohmann, Tibor Karl; Kanda, Hiroyuki; Morimoto, Takeshi; Endo, Takao; Miyoshi, Tomomitsu; Nishida, Kentaro; Kamei, Motohiro; Walter, Peter; Fujikado, Takashi


    To investigate the safety and efficacy of a newly-developed wide-field dual-array suprachoroidal-transretinal stimulation (STS) prosthesis in middle-sized animals. The prosthesis consisted of two arrays with 50 to 74 electrodes. To test the feasibility of implanting the prosthesis and its efficacy, the prosthesis was implanted for 14 days into two rabbits. Optical coherence tomography (OCT) and ophthalmoscopy were performed 7 and 14 days after the implantation. Then the rabbits were euthanized, eyes were enucleated, and the posterior segment of the eye was examined histologically. In a second experiment, the arrays were implanted into two cats, and their ability to elicit neural responses was determined by electrically evoked potentials (EEPs) at the chiasm and by optical imaging of the retina. All arrays were successfully implanted, and no major complications occurred during the surgery or during the 2-week postoperative period. Neither OCT nor ophthalmoscopy showed any major complications or instability of the arrays. Histological evaluations showed only mild cellular infiltration and overall good retinal preservation. Stimulation of the retina by the arrays evoked EEPs recorded from the chiasm. Retinal imaging showed that the electrical pulses from the arrays altered the retinal images indicating an activation of retinal neurons. The thresholds were as low as 100 μA for a chiasm response and 300 μA for the retinal imaging. Implantation of a newly-developed dual-array STS prosthesis for 2 weeks in rabbits was feasible surgically, and safe. The results of retinal imaging showed that the dual-array system was able to activate retinal neurons. We conclude that the dual-array design can be implanted without complication and is able to activate retinal neurons and optic nerve axons.

  14. Preliminary Analysis of Ground-based Orbit Determination Accuracy for the Wide Field Infrared Survey Telescope (WFIRST) (United States)

    Sease, Brad


    The Wide Field Infrared Survey Telescope is a 2.4-meter telescope planned for launch to the Sun-Earth L2 point in 2026. This paper details a preliminary study of the achievable accuracy for WFIRST from ground-based orbit determination routines. The analysis here is divided into two segments. First, a linear covariance analysis of early mission and routine operations provides an estimate of the tracking schedule required to meet mission requirements. Second, a simulated operations scenario gives insight into the expected behavior of a daily Extended Kalman Filter orbit estimate over the first mission year given a variety of potential momentum unloading schemes.

  15. Impacts on the Hubble Space Telescope Wide Field and Planetary Camera 2: Experimental Simulation of Micrometeoroid Capture (United States)

    Price, M. C.; Kearsley, A. T.; Wozniakiewicz, P. J.; Spratt, J.; Burchell, M. J.; Cole, M. J.; Anz-Meador, P.; Liou, J. C.; Ross, D. K.; Opiela, J.; hide


    Hypervelocity impact features have been recognized on painted surfaces returned from the Hubble Space Telescope (HST). Here we describe experiments that help us to understand their creation, and the preservation of micrometeoroid (MM) remnants. We simulated capture of silicate and sulfide minerals on the Zinc orthotitanate (ZOT) paint and Al alloy plate of the Wide Field and Planetary Camera 2 (WFPC2) radiator, which was returned from HST after 16 years in low Earth orbit (LEO). Our results also allow us to validate analytical methods for identification of MM (and orbital debris) impacts in LEO.

  16. Full-Field Indentation Damage Measurement Using Digital Image Correlation

    Directory of Open Access Journals (Sweden)

    Elías López-Alba


    Full Text Available A novel approach based on full-field indentation measurements to characterize and quantify the effect of contact in thin plates is presented. The proposed method has been employed to evaluate the indentation damage generated in the presence of bending deformation, resulting from the contact between a thin plate and a rigid sphere. For this purpose, the 3D Digital Image Correlation (3D-DIC technique has been adopted to quantify the out of plane displacements at the back face of the plate. Tests were conducted using aluminum thin plates and a rigid bearing sphere to evaluate the influence of the thickness and the material behavior during contact. Information provided by the 3D-DIC technique has been employed to perform an indirect measurement of the contact area during the loading and unloading path of the test. A symmetrical distribution in the contact damage region due to the symmetry of the indenter was always observed. In the case of aluminum plates, the presence of a high level of plasticity caused shearing deformation as the load increased. Results show the full-field contact damage area for different plates’ thicknesses at different loads. The contact damage region was bigger when the thickness of the specimen increased, and therefore, bending deformation was reduced. With the proposed approach, the elastic recovery at the contact location was quantified during the unloading, as well as the remaining permanent indentation damage after releasing the load. Results show the information obtained by full-field measurements at the contact location during the test, which implies a substantial improvement compared with pointwise techniques.

  17. "Adam Smith Meets Walt Disney": School Image on the World Wide Web (United States)

    Smith, Alison


    This article describes a small-scale research project undertaken as part of the coursework in a Doctor of Education programme. The project investigated the organisational images or identities portrayed by ten secondary schools in Auckland, New Zealand on their school websites. The recent proliferation of school websites has provided schools with a…

  18. [Imaging Blood Flow and Pulsation of Retinal Vessels with Full-Field Swept-Source OCT]. (United States)

    Spahr, H; Hillmann, D; Hain, C; Pfäffle, C; Sudkamp, H; Franke, G; Koch, P; Hüttmann, G


    Optical coherence tomography (OCT) uses interference to image the retina with high axial resolution. In the last 25 years, new technologies have permitted a steady increase in imaging speed, which made it possible to enlarge the imaged field and to avoid motion artefacts. The speed and precision of retinal imaging is now limited by photodamage of the retina caused by the focused OCT beam and by the speed of the scanning mechanics. Full-field swept-source (FF-SS)-OCT decreases irradiance on the retina and dispenses moving parts by using a camera to acquire the full volume of the retina in parallel. Here we show that FF-SS-OCT is rapid and precise enough to image pulsation in the retina induced by the heart beat. Series of OCT volumes 1.8 × 0.7 mm wide and 1.8 mm deep were recorded in young volunteers over a few cycles of the heart beat. Morphology of the retinal vessels, blood flow and tissue motion as caused by vessel pulsation were calculated from the OCT data. FF-SS-OCT was able to visualise the main structures of the neuronal retina, including vessels and small capillaries and without any motion artefacts. Information on three different dynamic processes was obtained from only one recorded series of OCT volumes: pulsation of blood flow and blood pressure in retinal vessels as well as pulsation of the choroid. Delays between arterial and venous pulse and delay between pulsation in retinal and choroidal vessels were calculated. With a time resolution of 0.5 ms, FF-SS-OCT is able to visualise previously unmeasurably fast changes in the retina, including the propagation of pulse waves. Georg Thieme Verlag KG Stuttgart · New York.

  19. The First Wide-field X-ray Imaging Telescope for Observations of Charge Exchange Project (United States)

    National Aeronautics and Space Administration — We will demonstrate a full, end-to-end, lobster-eye optic instrument at GSFC. The STORM prototype is fully self-contained, including integrated pre-amps, HV power...

  20. Optical imaging of nanosized structures by using plasmonically excited cascade near-field coupling with a carbon nanotube probe (United States)

    Watanabe, Masahiro; Tachizaki, Takehiro; Nakata, Toshihiko


    Near-field scanning optical microscopy (NSOM) overcomes the diffraction limit, thereby realizing a spatial resolution far beyond the wavelength of light used. However, NSOM still has a problem in repeatable imaging at the high spatial resolution and high contrast with conventional aperture or apertureless probes that are needed for practical applications. Here, we describe an optical imaging technique based on plasmonically excited cascade near-field coupling that has the potential to achieve single-nanometer spatial resolution with high imaging repeatability. This technique makes use of a plasmon waveguide coupled with a high-stiffness carbon nanotube optical probe. Through the action of surface plasmon polaritons, the input far-field light is converted into an optical near field that is used as an excitation source. This excitation near field is strongly enhanced and concentrated on the probe tip such that it generates a second near field as a nanosized probe spot on the apex of the tip. Extremely high-resolution optical imaging is accomplished by scanning the sample surface with the probe spot. At a wavelength of 850 nm, a 5-nm-wide metallic striped pattern on a cross-sectional superlattice sample was clearly resolved as a permittivity distribution.

  1. Ultra Wide X-Band Microwave Imaging of Concealed Weapons and Explosives Using 3D-SAR Technique

    Directory of Open Access Journals (Sweden)

    P. Millot


    Full Text Available In order to detect and image concealed weapons and explosives, an electromagnetic imaging tool with its related signal processing is presented. The aim is to penetrate clothes and to find personal-born weapons and explosives under clothes. The chosen UWB frequency range covers the whole X-band. The frequency range is justified after transmission measurements of numerous clothes that are dry or slightly wet. The apparatus and the 3D near-field SAR processor are described. A strategy for contour identification is presented with results of some simulants of weapon and explosive. A conclusion is drawn on the possible future of this technique.

  2. Electrical Resistance Tomography Field Trials to Image CO2 Sequestration (United States)

    Newmark, R.


    , telluric noise can be comparable to the signal levels during periods of geomagnetic activity. Finally, instrumentation stability over long periods is necessary to follow trends in reservoir behavior for several years. Solutions to these and other problems will be presented along with results from the first two years of work at a producing field undergoing CO2 flood. If electrical resistance tomography (ERT) imaging can be performed using existing well casings as long electrodes, it will substantially reduce the cost to monitor CO2 sequestration. This work was performed under the auspices of the U.S. Department of Energy by University of California Lawrence Livermore National Laboratory under contract No. W-7405-Eng-48.

  3. Wide-Field Landers Temporary Keratoprosthesis in Severe Ocular Trauma: Functional and Anatomical Results after One Year (United States)

    Nowomiejska, Katarzyna; Haszcz, Dariusz; Forlini, Cesare; Forlini, Matteo; Moneta-Wielgos, Joanna; Maciejewski, Ryszard; Zarnowski, Tomasz; Juenemann, Anselm G.


    Purpose. To evaluate longitudinal functional and anatomical results after combined pars plana vitrectomy (PPV) and penetrating keratoplasty (PKP) using a wide-field Landers intraoperative temporary keratoprosthesis (TKP) in patients with vitreoretinal pathology and corneal opacity due to severe ocular trauma. Material and Methods. Medical records of 12 patients who had undergone PPV/PKP/KP due to severe eye trauma were analyzed. Functional (best-corrected visual acuity) and anatomic outcomes (clarity of the corneal graft, retinal attachment, and intraocular pressure) were assessed during the follow-up (mean 16 months). Results. Final visual acuities varied from NLP to CF to 2 m. Visual acuity improved in 7 cases, was unchanged in 4 eyes, and worsened in 1 eye. The corneal graft was transparent during the follow-up in 3 cases and graft failure was observed in 9 eyes. Silicone oil was used as a tamponade in all cases and retina was reattached in 92% of cases. Conclusions. Combined PPV and PKP with the use of wide-field Landers TKP allowed for surgical intervention in patients with vitreoretinal pathology coexisting with corneal wound. Although retina was attached in most of the cases, corneal graft survived only in one-fourth of patients and final visual acuities were poor. PMID:26617994

  4. Wide-Field Landers Temporary Keratoprosthesis in Severe Ocular Trauma: Functional and Anatomical Results after One Year

    Directory of Open Access Journals (Sweden)

    Katarzyna Nowomiejska


    Full Text Available Purpose. To evaluate longitudinal functional and anatomical results after combined pars plana vitrectomy (PPV and penetrating keratoplasty (PKP using a wide-field Landers intraoperative temporary keratoprosthesis (TKP in patients with vitreoretinal pathology and corneal opacity due to severe ocular trauma. Material and Methods. Medical records of 12 patients who had undergone PPV/PKP/KP due to severe eye trauma were analyzed. Functional (best-corrected visual acuity and anatomic outcomes (clarity of the corneal graft, retinal attachment, and intraocular pressure were assessed during the follow-up (mean 16 months. Results. Final visual acuities varied from NLP to CF to 2 m. Visual acuity improved in 7 cases, was unchanged in 4 eyes, and worsened in 1 eye. The corneal graft was transparent during the follow-up in 3 cases and graft failure was observed in 9 eyes. Silicone oil was used as a tamponade in all cases and retina was reattached in 92% of cases. Conclusions. Combined PPV and PKP with the use of wide-field Landers TKP allowed for surgical intervention in patients with vitreoretinal pathology coexisting with corneal wound. Although retina was attached in most of the cases, corneal graft survived only in one-fourth of patients and final visual acuities were poor.

  5. World Wide Web platform-independent access to biomedical text/image databases (United States)

    Long, L. Rodney; Goh, Gin-Hua; Neve, Leif; Thoma, George R.


    The biomedical digital library of the future is expected to provide access to stores of biomedical database information containing text and images. Developing efficient methods for accessing such databases is a research effort at the Lister Hill National Center for Biomedical Communications of the National Library of Medicine. In this paper we examine issues in providing access to databases across the Web and describe a tool we have developed: the Web-based Medical Information Retrieval System (WebMIRS). We address a number of critical issues, including preservation of data integrity, efficient database design, access to documentation, quality of query and results interfaces, capability to export results to other software, and exploitation of multimedia data. WebMIRS is implemented as a Java applet that allows database access to text and to associated image data, without requiring any user software beyond a standard Web browser. The applet implementation allows WebMIRS to run on any hardware platform (such as PCs, the Macintosh, or Unix machines) which supports a Java-enabled Web browser, such as Netscape or Internet Explorer. WebMIRS is being tested on text/x-ray image databases created from the National Health and Nutrition Examination Surveys (NHANES) data collected by the National Center for Health Statistics.

  6. The Demographics and Properties of Wide-Orbit, Planetary-Mass Companions from PSF Fitting of Spitzer/IRAC Images (United States)

    Martinez, Raquel; Kraus, Adam L.


    Over the past decade, a growing population of planetary-mass companions ( 100 AU) from their host stars, challenging existing models of both star and planet formation. It is unclear whether these systems represent the low-mass extreme of stellar binary formation or the high-mass and wide-orbit extreme of planet formation theories, as various proposed formation pathways inadequately explain the physical and orbital aspects of these systems. Even so, determining which scenario best reproduces the observed characteristics of the PMCs will come once a statistically robust sample of directly-imaged PMCs are found and studied.We are developing an automated pipeline to search for wide-orbit PMCs to young stars in Spitzer/IRAC images. A Markov Chain Monte Carlo (MCMC) algorithm is the backbone of our novel point spread function (PSF) subtraction routine that efficiently creates and subtracts χ2-minimizing instrumental PSFs, simultaneously measuring astrometry and infrared photometry of these systems across the four IRAC channels (3.6 μm, 4.5 μm, 5.8 μm, and 8 μm). In this work, we present the results of a Spitzer/IRAC archival imaging study of 11 young, low-mass (0.044-0.88 M⊙ K3.5-M7.5) stars known to have faint, low-mass companions in 3 nearby star-forming regions (Chameleon, Taurus, and Upper Scorpius). We characterize the systems found to have low-mass companions with non-zero [I1] - [I4] colors, potentially signifying the presence of a circum(sub?)stellar disk. Plans for future pipeline improvements and paths forward will also be discussed. Once this computational foundation is optimized, the stage is set to quickly scour the nearby star-forming regions already imaged by Spitzer, identify potential candidates for further characterization with ground- or space-based telescopes, and increase the number of widely-separated PMCs known.

  7. Automated assessment of diabetic retinal image quality based on clarity and field definition. (United States)

    Fleming, Alan D; Philip, Sam; Goatman, Keith A; Olson, John A; Sharp, Peter F


    To evaluate the performance of an automated retinal image quality assessment system for use in automated diabetic retinopathy grading. Algorithmic methods have been developed for assessing the quality of 45 degrees single field retinal images for use in diabetic retinopathy screening. For this purpose, image quality was defined by two aspects: image clarity and field definition. An image with adequate clarity was defined as one that shows sufficient detail for automated retinopathy grading. The visibility of the macular vessels was used as an indicator of image clarity, since these vessels are known to be narrow and become less visible with any image degradation. An image with adequate field definition was defined as one that shows the desired field of view for retinopathy grading, including the full 45 degrees field of view, the optic disc, and at least two optic disc diameters of visible retina around the fovea. From 489 patients attending a diabetic retinopathy screening program, 1039 retinal images were obtained. The images were graded by a clinician for image clarity and field definition, with a comprehensive image-quality grading scheme. The sensitivity and specificity were, respectively, 100% and 90.9% for inadequate clarity detection, 95.3% and 96.4% for inadequate field definition detection, and 99.1% and 89.4% for inadequate overall quality detection. The automated system performs with sufficient accuracy to form part of an automated diabetic retinopathy grading system.

  8. Green-to-red photoconvertible fluorescent proteins: tracking cell and protein dynamics on standard wide-field mercury arc-based microscopes

    Directory of Open Access Journals (Sweden)

    Buckheit Robert W


    Full Text Available Abstract Background Green fluorescent protein (GFP and other FP fusions have been extensively utilized to track protein dynamics in living cells. Recently, development of photoactivatable, photoswitchable and photoconvertible fluorescent proteins (PAFPs has made it possible to investigate the fate of discrete subpopulations of tagged proteins. Initial limitations to their use (due to their tetrameric nature were overcome when monomeric variants, such as Dendra, mEos, and mKikGR were cloned/engineered. Results Here, we report that by closing the field diaphragm, selective, precise and irreversible green-to-red photoconversion (330-380 nm illumination of discrete subcellular protein pools was achieved on a wide-field fluorescence microscope equipped with standard DAPI, Fluorescein, and Rhodamine filter sets and mercury arc illumination within 5-10 seconds. Use of a DAPI-filter cube with long-pass emission filter (LP420 allowed the observation and control of the photoconversion process in real time. Following photoconversion, living cells were imaged for up to 5 hours often without detectable phototoxicity or photobleaching. Conclusions We demonstrate the practicability of this technique using Dendra2 and mEos2 as monomeric, photoconvertible PAFP representatives fused to proteins with low (histone H2B, medium (gap junction channel protein connexin 43, and high (α-tubulin; clathrin light chain dynamic cellular mobility as examples. Comparable efficient, irreversible green-to-red photoconversion of selected portions of cell nuclei, gap junctions, microtubules and clathrin-coated vesicles was achieved. Tracking over time allowed elucidation of the dynamic live-cycle of these subcellular structures. The advantage of this technique is that it can be performed on a standard, relatively inexpensive wide-field fluorescence microscope with mercury arc illumination. Together with previously described laser scanning confocal microscope-based photoconversion

  9. High Resolution Multispectral Flow Imaging of Cells with Extended Depth of Field Project (United States)

    National Aeronautics and Space Administration — Proposed is the development the extended depth of field (EDF) or confocal like imaging capabilities of a breakthrough multispectral high resolution imaging flow...

  10. Wide-area mapping of resting state hemodynamic correlations at microvascular resolution with multi-contrast optical imaging (Conference Presentation) (United States)

    Senarathna, Janaka; Hadjiabadi, Darian; Gil, Stacy; Thakor, Nitish V.; Pathak, Arvind P.


    Different brain regions exhibit complex information processing even at rest. Therefore, assessing temporal correlations between regions permits task-free visualization of their `resting state connectivity'. Although functional MRI (fMRI) is widely used for mapping resting state connectivity in the human brain, it is not well suited for `microvascular scale' imaging in rodents because of its limited spatial resolution. Moreover, co-registered cerebral blood flow (CBF) and total hemoglobin (HbT) data are often unavailable in conventional fMRI experiments. Therefore, we built a customized system that combines laser speckle contrast imaging (LSCI), intrinsic optical signal (IOS) imaging and fluorescence imaging (FI) to generate multi-contrast functional connectivity maps at a spatial resolution of 10 μm. This system comprised of three illumination sources: a 632 nm HeNe laser (for LSCI), a 570 nm ± 5 nm filtered white light source (for IOS), and a 473 nm blue laser (for FI), as well as a sensitive CCD camera operating at 10 frames per second for image acquisition. The acquired data enabled visualization of changes in resting state neurophysiology at microvascular spatial scales. Moreover, concurrent mapping of CBF and HbT-based temporal correlations enabled in vivo mapping of how resting brain regions were linked in terms of their hemodynamics. Additionally, we complemented this approach by exploiting the transit times of a fluorescent tracer (Dextran-FITC) to distinguish arterial from venous perfusion. Overall, we demonstrated the feasibility of wide area mapping of resting state connectivity at microvascular resolution and created a new toolbox for interrogating neurovascular function.

  11. Imaging end-stage kidney disease in adults: low-field MR imaging with magnetization transfer vs. ultrasonography

    Energy Technology Data Exchange (ETDEWEB)

    Kajander, S.; Kallio, T.; Alanen, A.; Komu, M. [Univ. Hospital of Turku (Finland). Dept. of Diagnostic Radiology; Forsstroem, J. [Univ. Hospital of Turku (Finland). Dept. of Medicine


    Purpose: To (1) assess the potential of magnetization transfer (MT)-weighted MR imaging to improve the often poor visibility of native kidneys in patients with a renal transplant; and (2) compare low-field MR imaging and ultrasonography (US) for imaging these fibrotic kidney remnants. Material and Methods: Seventy-two native kidneys of 36 patients were prospectively evaluated with US and MR. In low-field (0.1 T) MR imaging, T1-, T2- and MT-weighted sequences were used. MT-weighted images were compared with T2-weighted images in their ability to delineate the kidneys from their surroundings whereas US and MR were compared for detection of renal cysts and possible solid tumors. Results: MT-weighted images proved superior to conventional T2-weighted images in producing contrast between the kidney remnants and their fatty surroundings. Although US revealed a few small renal cysts that were not seen at MR images, no statistical difference was found between the two modalities in this respect. Conclusion: MT imaging, due to its unique protein-specific signal depression, offers significantly improved visualization and delineation of end-stage kidneys. US, because its better availability and cost-benefit ratio, remains the method-of-choice compared to low-field MR imaging in detecting cysts in multicystic kidneys. MR investigation is helpful in selected patients and may be used as an alternative. Keywords: Kidneys, MR imaging; technology; ultrasonography.

  12. Whole-field thickness strain measurement using multiple camera digital image correlation system (United States)

    Li, Junrui; Xie, Xin; Yang, Guobiao; Zhang, Boyang; Siebert, Thorsten; Yang, Lianxiang.


    Three Dimensional digital image correlation(3D-DIC) has been widely used by industry, especially for strain measurement. The traditional 3D-DIC system can accurately obtain the whole-field 3D deformation. However, the conventional 3D-DIC system can only acquire the displacement field on a single surface, thus lacking information in the depth direction. Therefore, the strain in the thickness direction cannot be measured. In recent years, multiple camera DIC (multi-camera DIC) systems have become a new research topic, which provides much more measurement possibility compared to the conventional 3D-DIC system. In this paper, a multi-camera DIC system used to measure the whole-field thickness strain is introduced in detail. Four cameras are used in the system. two of them are placed at the front side of the object, and the other two cameras are placed at the back side. Each pair of cameras constitutes a sub stereo-vision system and measures the whole-field 3D deformation on one side of the object. A special calibration plate is used to calibrate the system, and the information from these two subsystems is linked by the calibration result. Whole-field thickness strain can be measured using the information obtained from both sides of the object. Additionally, the major and minor strain on the object surface are obtained simultaneously, and a whole-field quasi 3D strain history is acquired. The theory derivation for the system, experimental process, and application of determining the thinning strain limit based on the obtained whole-field thickness strain history are introduced in detail.

  13. Neutron dark field imaging of domain structures in superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Reimann, Tommy; Schulz, Michael [TU Muenchen, Forschungsneutronenquelle Heinz Maier Leibnitz (FRM II), 85747 Garching (Germany); Physik Department E21, TU Muenchen, 85747 Garching (Germany); Gruenzweig, Christian [Paul-Scherrer-Institut, CH-5232 Villigen (Switzerland); Muehlbauer, Sebastian [TU Muenchen, Forschungsneutronenquelle Heinz Maier Leibnitz (FRM II), 85747 Garching (Germany); Boeni, Peter [Physik Department E21, TU Muenchen, 85747 Garching (Germany)


    In the intermediate mixed state (IMS) of a type II superconductor (SC), the sample splits up into field-free Meissner domains and Shubnikov domains which carry the vortex lattice. The IMS is analog to the intermediate state (IS) of a type-I superconductor with normal and superconducting domains. Experiments on the topology of both states show a variety of different patterns including striped, dendritic and bubble phases, which represent typical domain morphologies also seen in various other physical contexts. A detailed investigation of domain patterns offers the possibility to study general characteristics of domain nucleation and morphology as well as the physical properties of vortex-vortex interactions. Domain structures in SC are typically investigated by surface sensitive techniques such as magneto optical imaging, but flux pinning as well as Landau branching can significantly hamper the deduction of bulk properties. In this talk we show how neutron grating interferometry (nGI) can be used as a tool for the unambiguous identification of bulk properties. The capability of this unique technique will be demonstrated on Pb and Nb single crystals, which are classical representatives of type I and type II SC respectively.

  14. Review of near-field optics and superlenses for sub-diffraction-limited nano-imaging

    Directory of Open Access Journals (Sweden)

    Wyatt Adams


    Full Text Available Near-field optics and superlenses for imaging beyond Abbe’s diffraction limit are reviewed. A comprehensive and contemporary background is given on scanning near-field microscopy and superlensing. Attention is brought to recent research leveraging scanning near-field optical microscopy with superlenses for new nano-imaging capabilities. Future research directions are explored for realizing the goal of low-cost and high-performance sub-diffraction-limited imaging systems.

  15. Pelvic endometriosis: a comparison between low-field (0.2 T) and high-field (1.5 T) magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Minaif, Karine; Ajzen, Sergio [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Dept. of Imaging Diagnosis]. E-mail:; Shigueoka, David Carlos; Minami, Cintia Cristina Satie; Sales, Danilo Moulin; Szejnfeld, Jacob [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Dept. of Imaging Diagnosis. Unit of Abdomen; Ruano, Jose Maria Cordeiro [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Dept. of General Gynecology. Sector of Videlaparoscopy; Noguti, Alberto Sinhiti [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Dept. of General Gynecology


    Objective: to compare low-field (0.2 T) with high-field (1.5 T) magnetic resonance imaging in the assessment of pelvic endometriosis and adenomyosis. Materials and methods: twenty-seven female patients with clinically suspected endometriosis were prospectively evaluated by means of high-field and low-field magnetic resonance imaging. The reading of the images was performed by a single radiologist, initiating by the low-field, followed by the high-field images. High-field magnetic resonance imaging was utilized as the golden-standard. Results: among the 27 patients included in the present study, 18 (66.7%) had some type of lesion suggesting the presence of endometriosis demonstrated at high-field images. In 14 of these patients the diagnosis was correctly established by low-field magnetic resonance imaging. Endometriomas, tubal lesions, and endometriotic foci > 7 mm identified at the high-field images were also identified at low-field images with 100% accuracy, sensitivity and specificity. Among the nine patients diagnosed with adenomyosis by high-field images, eight were correctly diagnosed by low-field images with 88.9% accuracy, specificity and sensitivity. Conclusion: low-field magnetic resonance imaging demonstrated a low sensitivity in the detection of small endometriotic foci, high sensitivity in the detection of endometriomas and large endometriotic foci, and high accuracy in the detection of adenomyosis when compared with high-field magnetic resonance imaging. (author)


    Directory of Open Access Journals (Sweden)

    Iancu Ioana Ancuta


    Full Text Available In a world where the internet and its image are becoming more and more important, this study is about the importance of Investment and Financial Services Companies web sites. Market competition, creates the need of studies, focused on assessing and analyzing the websites of companies who are active in this sector. Our study wants to respond at several questions related to Romanian Investment and Financial Services Companies web sites through four dimensions: content, layout, handling and interactivity. Which web sites are best and from what point of view? Where should financial services companies direct their investments to differentiate themselves and their sites? In fact we want to rank the 58 Investment and Financial Services Companies web sites based on 127 criteria. There are numerous methods for evaluating web pages. The evaluation methods are similar from the structural point of view and the most popular are: Serqual, Sitequal, Webqual / Equal EtailQ, Ewam, e-Serqual, WebQEM (Badulescu, 2008:58. In the paper: "Assessment of Romanian Banks E-Image: A Marketing Perspective" (Catana, Catana and Constantinescu, 2006: 4 the authors point out that there are at least four complex variables: accessibility, functionality, performance and usability. Each of these can be decomposed into simple ones. We used the same method, and we examined from the utility point of view, 58 web sites of Investment and Financial Services Companies based on 127 criteria following a procedure developed by Institut fur ProfNet Internet Marketing, Munster (Germany. The data collection period was 1-30 September 2010. The results show that there are very large differences between corporate sites; their creators are concentrating on the information required by law and aesthetics, neglecting other aspects as communication and online service. In the future we want to extend this study at international level, by applying the same methods of research in 5 countries from

  17. Analysis of image distortion based on light ray field by multi-view and horizontal parallax only integral imaging display. (United States)

    Kim, Hee-Seung; Jeong, Kyeong-Min; Hong, Sung-In; Jo, Na-Young; Park, Jae-Hyeung


    Three-dimensional image distortion caused by mismatch between autostereoscopic displays and contents is analyzed. For a given three-dimensional object scene, the original light ray field in the contents and deformed one by the autostereoscopic displays are calculated. From the deformation of the light ray field, the distortion of the resultant three-dimensional image is finally deduced. The light ray field approach enables generalized distortion analysis across different autostereoscopic display techniques. The analysis result is verified experimentally when multi-view contents are applied to a multi-view display of non-matching parameters and a horizontal parallax only integral imaging display.

  18. PYM: a new, affordable, image-based method using a Raspberry Pi to phenotype plant leaf area in a wide diversity of environments

    Directory of Open Access Journals (Sweden)

    Benoît Valle


    Full Text Available Abstract Background Plant science uses increasing amounts of phenotypic data to unravel the complex interactions between biological systems and their variable environments. Originally, phenotyping approaches were limited by manual, often destructive operations, causing large errors. Plant imaging emerged as a viable alternative allowing non-invasive and automated data acquisition. Several procedures based on image analysis were developed to monitor leaf growth as a major phenotyping target. However, in most proposals, a time-consuming parameterization of the analysis pipeline is required to handle variable conditions between images, particularly in the field due to unstable light and interferences with soil surface or weeds. To cope with these difficulties, we developed a low-cost, 2D imaging method, hereafter called PYM. The method is based on plant leaf ability to absorb blue light while reflecting infrared wavelengths. PYM consists of a Raspberry Pi computer equipped with an infrared camera and a blue filter and is associated with scripts that compute projected leaf area. This new method was tested on diverse species placed in contrasting conditions. Application to field conditions was evaluated on lettuces grown under photovoltaic panels. The objective was to look for possible acclimation of leaf expansion under photovoltaic panels to optimise the use of solar radiation per unit soil area. Results The new PYM device proved to be efficient and accurate for screening leaf area of various species in wide ranges of environments. In the most challenging conditions that we tested, error on plant leaf area was reduced to 5% using PYM compared to 100% when using a recently published method. A high-throughput phenotyping cart, holding 6 chained PYM devices, was designed to capture up to 2000 pictures of field-grown lettuce plants in less than 2 h. Automated analysis of image stacks of individual plants over their growth cycles revealed unexpected

  19. PYM: a new, affordable, image-based method using a Raspberry Pi to phenotype plant leaf area in a wide diversity of environments. (United States)

    Valle, Benoît; Simonneau, Thierry; Boulord, Romain; Sourd, Francis; Frisson, Thibault; Ryckewaert, Maxime; Hamard, Philippe; Brichet, Nicolas; Dauzat, Myriam; Christophe, Angélique


    Plant science uses increasing amounts of phenotypic data to unravel the complex interactions between biological systems and their variable environments. Originally, phenotyping approaches were limited by manual, often destructive operations, causing large errors. Plant imaging emerged as a viable alternative allowing non-invasive and automated data acquisition. Several procedures based on image analysis were developed to monitor leaf growth as a major phenotyping target. However, in most proposals, a time-consuming parameterization of the analysis pipeline is required to handle variable conditions between images, particularly in the field due to unstable light and interferences with soil surface or weeds. To cope with these difficulties, we developed a low-cost, 2D imaging method, hereafter called PYM. The method is based on plant leaf ability to absorb blue light while reflecting infrared wavelengths. PYM consists of a Raspberry Pi computer equipped with an infrared camera and a blue filter and is associated with scripts that compute projected leaf area. This new method was tested on diverse species placed in contrasting conditions. Application to field conditions was evaluated on lettuces grown under photovoltaic panels. The objective was to look for possible acclimation of leaf expansion under photovoltaic panels to optimise the use of solar radiation per unit soil area. The new PYM device proved to be efficient and accurate for screening leaf area of various species in wide ranges of environments. In the most challenging conditions that we tested, error on plant leaf area was reduced to 5% using PYM compared to 100% when using a recently published method. A high-throughput phenotyping cart, holding 6 chained PYM devices, was designed to capture up to 2000 pictures of field-grown lettuce plants in less than 2 h. Automated analysis of image stacks of individual plants over their growth cycles revealed unexpected differences in leaf expansion rate between

  20. Magneto acoustic tomography with short pulsed magnetic field for in-vivo imaging of magnetic iron oxide nanoparticles. (United States)

    Mariappan, Leo; Shao, Qi; Jiang, Chunlan; Yu, Kai; Ashkenazi, Shai; Bischof, John C; He, Bin


    Nanoparticles are widely used as contrast and therapeutic agents. As such, imaging modalities that can accurately estimate their distribution in-vivo are actively sought. We present here our method Magneto Acoustic Tomography (MAT), which uses magnetomotive force due to a short pulsed magnetic field to induce ultrasound in the magnetic nanoparticle labeled tissue and estimates an image of the distribution of the nanoparticles in-vivo with ultrasound imaging resolution. In this study, we image the distribution of superparamagnetic iron oxide nanoparticles (IONP) using MAT method. In-vivo imaging was performed on live, nude mice with IONP injected into LNCaP tumors grown subcutaneously within the hind limb of the mice. Our experimental results indicate that the MAT method is capable of imaging the distribution of IONPs in-vivo. Therefore, MAT could become an imaging modality for high resolution reconstruction of MNP distribution in the body. Many magnetic nanoparticles (MNPs) have been used as contrast agents in magnetic resonance imaging. In this study, the authors investigated the use of ultrasound to detect the presence of MNPs by magneto acoustic tomography. In-vivo experiments confirmed the imaging quality of this new approach, which hopefully would provide an alternative method for accurate tumor detection. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. A Panchromatic Catalog of Early-type Galaxies at Intermediate Redshift in the Hubble Space Telescope Wide Field Camera 3 Early Release Science Field (United States)

    Rutkowski, M. J.; Cohen, S. H.; Kaviraj, S.; O'Connell, R. W.; Hathi, N. P.; Windhorst, R. A.; Ryan, R. E., Jr.; Crockett, R. M.; Yan, H.; Kimble, R. A.; Silk, J.; McCarthy, P. J.; Koekemoer, A.; Balick, B.; Bond, H. E.; Calzetti, D.; Disney, M. J.; Dopita, M. A.; Frogel, J. A.; Hall, D. N. B.; Holtzman, J. A.; Paresce, F.; Saha, A.; Trauger, J. T.; Walker, A. R.; Whitmore, B. C.; Young, E. T.


    In the first of a series of forthcoming publications, we present a panchromatic catalog of 102 visually selected early-type galaxies (ETGs) from observations in the Early Release Science (ERS) program with the Wide Field Camera 3 (WFC3) on the Hubble Space Telescope (HST) of the Great Observatories Origins Deep Survey-South (GOODS-S) field. Our ETGs span a large redshift range, 0.35 lsim z lsim 1.5, with each redshift spectroscopically confirmed by previous published surveys of the ERS field. We combine our measured WFC3 ERS and Advanced Camera for Surveys (ACS) GOODS-S photometry to gain continuous sensitivity from the rest-frame far-UV to near-IR emission for each ETG. The superior spatial resolution of the HST over this panchromatic baseline allows us to classify the ETGs by their small-scale internal structures, as well as their local environment. By fitting stellar population spectral templates to the broadband photometry of the ETGs, we determine that the average masses of the ETGs are comparable to the characteristic stellar mass of massive galaxies, 1011 publications which address the diversity of stellar populations likely to be present in these ETGs, and the potential mechanisms by which recent star formation episodes are activated, are discussed.

  2. Towards Motion-Insensitive Magnetic Resonance Imaging Using Dynamic Field Measurements

    DEFF Research Database (Denmark)

    Andersen, Mads

    image quality degradation for certain brain imaging sequences through this effect. It has previously been shown that magnetic field sensors (field probes) can be applied to stabilize the B0 field during scanning. However, the field probes are placed around the head, while it is the B0-fluctuations...... inside the head that are of interest. This interpolation problem is the subject of the last study inthe thesis. Experiments were performed with healthy volunteers to test how field estimates in the brain based on outside field probe measurements compare to field measurements performed in the brain...

  3. Experimental studies of far-field superlens for sub-diffractional optical imaging. (United States)

    Liu, Zhaowei; Durant, Stéphane; Lee, Hyesog; Pikus, Yuri; Xiong, Yi; Sun, Cheng; Zhang, Xiang


    Contrary to the conventional near-field superlensing, subwavelength superlens imaging is experimentally demonstrated in the far-field. The key element is termed as a Far-field SuperLens (FSL) which consists of a conventional superlens and a nanoscale coupler. The evanescent fields from the object are enhanced and then converted into propagating fields by the FSL. By only measuring the propagating field in the far-field, the object image can be reconstructed with subwavelength resolution. As an example of this concept, we design and fabricate a silver structured one dimensional FSL. Experimental results show that feature resolution of better than 50nm is possible using current FSL design.

  4. A search for a distant companion to the sun with the wide-field infrared survey explorer

    Energy Technology Data Exchange (ETDEWEB)

    Luhman, K. L., E-mail: [Department of Astronomy and Astrophysics, The Pennsylvania State University, University Park, PA 16802 (United States); Center for Exoplanets and Habitable Worlds, The Pennsylvania State University, University Park, PA 16802 (United States)


    I have used multi-epoch astrometry from the Wide-field Infrared Survey Explorer to perform a search for a distant companion to the Sun via its parallactic motion. I have not found an object of this kind down to W2 = 14.5. This limit corresponds to analogs of Saturn and Jupiter at 28,000 and 82,000 AU, respectively, according to models of the Jovian planets by Fortney and coworkers. Models of brown dwarfs by Burrows and coworkers predict fainter fluxes at a given mass for the age of the solar system, producing a closer distance limit of 26,000 AU for a Jupiter-mass brown dwarf. These constraints exclude most combinations of mass and separation at which a solar companion has been suggested to exist by various studies over the years.

  5. Impacts on the Hubble Space Telescope Wide Field and Planetary Camera 2: Microanalysis and Recognition of Micrometeoroid Compositions (United States)

    Kearsley, A. T.; Ross, D. K.; Anz-Meador, P.; Liou, J. C.; Opiela, J.; Grime, G. W.; Webb, R. P.; Jeynes, C.; Palitsin, V. V.; Colaux, J. L.; hide


    Postflight surveys of the Wide Field and Planetary Camera 2 (WFPC2) on the Hubble Space Telescope have located hundreds of features on the 2.2 by 0.8 m curved plate, evidence of hypervelocity impact by small particles during 16 years of exposure to space in low Earth orbit (LEO). The radiator has a 100 - 200 micron surface layer of white paint, overlying 4 mm thick Al alloy, which was not fully penetrated by any impact. Over 460 WFPC2 samples were extracted by coring at JSC. About half were sent to NHM in a collaborative program with NASA, ESA and IBC. The structural and compositional heterogeneity at micrometer scale required microanalysis by electron and ion beam microscopes to determine the nature of the impactors (artificial orbital debris, or natural micrometeoroids, MM). Examples of MM impacts are described elsewhere. Here we describe the development of novel electron beam analysis protocols, required to recognize the subtle traces of MM residues.

  6. Micrometeoroid Impacts on the Hubble Sace Telescope Wide Field and Planetary Camera 2: Ion Beam Analysis of Subtle Impactor Traces (United States)

    Grime, G. W.; Webb, R. P.; Jeynes, C.; Palitsin, V. V.; Colaux, J. L.; Kearsley, A. T.; Ross, D. K.; Anz-Meador, P.; Liou, J. C.; Opiela, J.; hide


    Recognition of origin for particles responsible for impact damage on spacecraft such as the Hubble Space Telescope (HST) relies upon postflight analysis of returned materials. A unique opportunity arose in 2009 with collection of the Wide Field and Planetary Camera 2 (WFPC2) from HST by shuttle mission STS-125. A preliminary optical survey confirmed that there were hundreds of impact features on the radiator surface. Following extensive discussion between NASA, ESA, NHM and IBC, a collaborative research program was initiated, employing scanning electron microscopy (SEM) and ion beam analysis (IBA) to determine the nature of the impacting grains. Even though some WFPC2 impact features are large, and easily seen without the use of a microscope, impactor remnants may be hard to find.

  7. Wide-field infrared survey explorer observations of young stellar objects in the Lynds 1509 dark cloud in Auriga

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Wilson M.; McCollum, Bruce; Fajardo-Acosta, Sergio [Infrared Processing and Analysis Center, California Institute of Technology, MC 100-22, Pasadena, CA 91125 (United States); Padgett, Deborah L. [National Aeronautics and Space Administration, Goddard Space Flight Center, Code 665, Greenbelt, MD 20771 (United States); Terebey, Susan; Angione, John [Department of Physics and Astronomy, California State University, Los Angeles, CA 90032 (United States); Rebull, Luisa M. [Spitzer Science Center, California Institute of Technology, MC 314-6, Pasadena, CA 91125 (United States); Leisawitz, David, E-mail: [National Aeronautics and Space Administration, Goddard Space Flight Center, Code 605, Greenbelt, MD 20771 (United States)


    The Wide-Field Infrared Survey Explorer (WISE) has uncovered a striking cluster of young stellar object (YSO) candidates associated with the L1509 dark cloud in Auriga. The WISE observations, at 3.4 μm, 4.6 μm, 12 μm, and 22 μm, show a number of objects with colors consistent with YSOs, and their spectral energy distributions suggest the presence of circumstellar dust emission, including numerous Class I, flat spectrum, and Class II objects. In general, the YSOs in L1509 are much more tightly clustered than YSOs in other dark clouds in the Taurus-Auriga star forming region, with Class I and flat spectrum objects confined to the densest aggregates, and Class II objects more sparsely distributed. We estimate a most probable distance of 485-700 pc, and possibly as far as the previously estimated distance of 2 kpc.

  8. Imaging of Interlayer Coupling in van der Waals Heterostructures Using a Bright-Field Optical Microscope (United States)

    Alexeev, Evgeny M.; Catanzaro, Alessandro; Skrypka, Oleksandr V.; Nayak, Pramoda K.; Ahn, Seongjoon; Pak, Sangyeon; Lee, Juwon; Sohn, Jung Inn; Novoselov, Kostya S.; Shin, Hyeon Suk; Tartakovskii, Alexander I.


    Vertically stacked atomic layers from different layered crystals can be held together by van der Waals forces, which can be used for building novel heterostructures, offering a platform for developing a new generation of atomically thin, transparent and flexible devices. The performance of these devices is critically dependent on the layer thickness and the interlayer electronic coupling, influencing the hybridisation of the electronic states as well as charge and energy transfer between the layers. The electronic coupling is affected by the relative orientation of the layers as well as by the cleanliness of their interfaces. Here, we demonstrate an efficient method for monitoring interlayer coupling in heterostructures made from transition metal dichalcogenides using photoluminescence imaging in a bright-field optical microscope. The colour and brightness in such images are used here to identify mono- and few-layer crystals, and to track changes in the interlayer coupling and the emergence of interlayer excitons after thermal annealing in mechanically exfoliated flakes as well as a function of the twist angle in atomic layers grown by chemical vapour deposition. Material and crystal thickness sensitivity of the presented imaging technique makes it a powerful tool for characterisation of van der Waals heterostructures assembled by a wide variety of methods, using combinations of materials obtained through mechanical or chemical exfoliation and crystal growth.

  9. Imaging of Interlayer Coupling in van der Waals Heterostructures Using a Bright-Field Optical Microscope. (United States)

    Alexeev, Evgeny M; Catanzaro, Alessandro; Skrypka, Oleksandr V; Nayak, Pramoda K; Ahn, Seongjoon; Pak, Sangyeon; Lee, Juwon; Sohn, Jung Inn; Novoselov, Kostya S; Shin, Hyeon Suk; Tartakovskii, Alexander I


    Vertically stacked atomic layers from different layered crystals can be held together by van der Waals forces, which can be used for building novel heterostructures, offering a platform for developing a new generation of atomically thin, transparent, and flexible devices. The performance of these devices is critically dependent on the layer thickness and the interlayer electronic coupling, influencing the hybridization of the electronic states as well as charge and energy transfer between the layers. The electronic coupling is affected by the relative orientation of the layers as well as by the cleanliness of their interfaces. Here, we demonstrate an efficient method for monitoring interlayer coupling in heterostructures made from transition metal dichalcogenides using photoluminescence imaging in a bright-field optical microscope. The color and brightness in such images are used here to identify mono- and few-layer crystals and to track changes in the interlayer coupling and the emergence of interlayer excitons after thermal annealing in heterobilayers composed of mechanically exfoliated flakes and as a function of the twist angle in atomic layers grown by chemical vapor deposition. Material and crystal thickness sensitivity of the presented imaging technique makes it a powerful tool for characterization of van der Waals heterostructures assembled by a wide variety of methods, using combinations of materials obtained through mechanical or chemical exfoliation and crystal growth.

  10. Biologically motivated composite image sensor for deep-field target tracking (United States)

    Melnyk, Pavlo B.; Messner, Richard A.


    The present work addresses the design of an image acquisition front-end for target detection and tracking within a wide range of distances. Inspired by raptor bird's vision, a novel design for a visual sensor is proposed. The sensor consists of two parts, each originating from the studies of biological vision systems of different species. The front end is comprised of a set of video cameras imitating a falconiform eye, in particular its optics and retina [1]. The back end is a software remapper that uses a popular in machine vision log-polar model of retino-cortical projection in primates [2], [3], [4]. The output of this sensor is a composite log-polar image incorporating both near and far visual fields into a single homogeneous image space. In such space it is easier to perform target detection and tracking for those applications that deal with targets moving along the camera axis. The target object preserves its shape and size being handled seamlessly between cameras regardless of distance to the composite sensor. The prototype of proposed composite sensor has been created and is used as a front-end in experimental mobile vehicle detection and tracking system. Its has been tested inside a driving simulator and results are presented.

  11. Development of a lightweight near-zero CTE optical bench for the Wide-Field Camera 3 instrument (United States)

    Holz, Jill M.; Kunt, Cengiz; Lashley, Chris; McGuffey, Douglas B.


    The design and development of an optical bench (OB) for Wide Field Camera 3 (WFC3), a next generation science instrument for the Hubble Space Telescope (HST) has proven a challenging task. WFC3 will replace Wide Field Planetary Camera 2 (WF/PC 2) during the next servicing mission of the HST in 2004. The WFC3 program is re-using much of the hardware from WF/PC 1, returned from the First Servicing Mission, which has added complexity to the program. This posed some significant packaging challenges, further complicated by WFC3 utilizing two, separate optical channels. The WF/PC 1 optical bench could not house the additional optical components, so a new bench was developed. The new bench had to be designed to accommodate the sometimes-conflicting requirements of the two channels, which operate over a wavelength range of 200nm to 1800nm, from Near Ultraviolet to Near Infrared. In addition, the bench had to interface to the reused WF/PC 1 hardware, which was not optimized for this mission. To aid in the design of the bench, the team used software tools to merge structural, thermal and optical models to obtain performance (STOP) of the optical systems in operation. Several iterations of this performance analysis were needed during the design process to verify the bench would meet requirements. The fabrication effort included a rigorous material characterization program and significant tooling. After assembly, the optical bench underwent an extensive qualification program to prove the design and manufacturing processes. This paper provides the details of the design and development process of this highly optimized optical bench.

  12. A Multi-Frequency Wide-Swath Spaceborne Cloud and Precipitation Imaging Radar (United States)

    Li, Lihua; Racette, Paul; Heymsfield, Gary; McLinden, Matthew; Venkatesh, Vijay; Coon, Michael; Perrine, Martin; Park, Richard; Cooley, Michael; Stenger, Pete; hide


    Microwave and millimeter-wave radars have proven their effectiveness in cloud and precipitation observations. The NASA Earth Science Decadal Survey (DS) Aerosol, Cloud and Ecosystems (ACE) mission calls for a dual-frequency cloud radar (W band 94 GHz and Ka-band 35 GHz) for global measurements of cloud microphysical properties. Recently, there have been discussions of utilizing a tri-frequency (KuKaW-band) radar for a combined ACE and Global Precipitation Measurement (GPM) follow-on mission that has evolved into the Cloud and Precipitation Process Mission (CaPPM) concept. In this presentation we will give an overview of the technology development efforts at the NASA Goddard Space Flight Center (GSFC) and at Northrop Grumman Electronic Systems (NGES) through projects funded by the NASA Earth Science Technology Office (ESTO) Instrument Incubator Program (IIP). Our primary objective of this research is to advance the key enabling technologies for a tri-frequency (KuKaW-band) shared-aperture spaceborne imaging radar to provide unprecedented, simultaneous multi-frequency measurements that will enhance understanding of the effects of clouds and precipitation and their interaction on Earth climate change. Research effort has been focused on concept design and trade studies of the tri-frequency radar; investigating architectures that provide tri-band shared-aperture capability; advancing the development of the Ka band active electronically scanned array (AESA) transmitreceive (TR) module, and development of the advanced radar backend electronics.

  13. Community-wide Validation of Geospace Model Ground Magnetic Field Perturbation Predictions to Support Model Transition to Operations (United States)

    Pulkkinen, A.; Rastaetter, L.; Kuznetsova, M.; Singer, H.; Balch, C.; Weimer, D.; Toth, G.; Ridley, A.; Gombosi, T.; Wiltberger, M.; hide


    In this paper we continue the community-wide rigorous modern space weather model validation efforts carried out within GEM, CEDAR and SHINE programs. In this particular effort, in coordination among the Community Coordinated Modeling Center (CCMC), NOAA Space Weather Prediction Center (SWPC), modelers, and science community, we focus on studying the models' capability to reproduce observed ground magnetic field fluctuations, which are closely related to geomagnetically induced current phenomenon. One of the primary motivations of the work is to support NOAA SWPC in their selection of the next numerical model that will be transitioned into operations. Six geomagnetic events and 12 geomagnetic observatories were selected for validation.While modeled and observed magnetic field time series are available for all 12 stations, the primary metrics analysis is based on six stations that were selected to represent the high-latitude and mid-latitude locations. Events-based analysis and the corresponding contingency tables were built for each event and each station. The elements in the contingency table were then used to calculate Probability of Detection (POD), Probability of False Detection (POFD) and Heidke Skill Score (HSS) for rigorous quantification of the models' performance. In this paper the summary results of the metrics analyses are reported in terms of POD, POFD and HSS. More detailed analyses can be carried out using the event by event contingency tables provided as an online appendix. An online interface built at CCMC and described in the supporting information is also available for more detailed time series analyses.

  14. Extracting 220 Hz information from 55 Hz field data by near-field superresolution imaging

    KAUST Repository

    Dutta, Gaurav


    Field experiments are used to unequivocally demonstrate seismic superresolution imaging of subwavelength objects in the near-field region of the source. The field test is for a conventional hammer source striking a metal plate near subwavelength scatterers and the seismic data are recorded by vertical-component geophones in the far-field locations of the sources. Time-reversal mirrors (TRMs) are then used to refocus the scattered energy with subwavelength resolution to the position of the original source. A spatial resolution of lambda/10, where lambda is the dominant wavelength associated with the data, is seen in the field tests that exceeds the Abbe resolution limit of lambda/2.

  15. Direct wide-angle measurement of a photonic band structure in a three-dimensional photonic crystal using infrared Fourier imaging spectroscopy. (United States)

    Chen, Lifeng; Lopez-Garcia, Martin; Taverne, Mike P C; Zheng, Xu; Ho, Ying-Lung D; Rarity, John


    We propose a method to directly visualize the photonic band-structure of micrometer-sized photonic crystals using wide-angle spectroscopy. By extending Fourier imaging spectroscopy sensitivity into the infrared range, we have obtained accurate measurements of the band structures along the high-symmetry directions (X-W-K-L-U) of polymeric three-dimensional, rod-connected diamond photonic crystals. Our implementation also allows us to record single-wavelength reflectance far-field patterns showing very good agreement with simulations of the same designs. This technique is suitable for the characterization of photonic structures working in the infrared and, in particular, to obtain band-structure information of complete photonic band gap materials.

  16. Soft x-ray free-electron laser imaging by LiF crystal and film detectors over a wide range of fluences. (United States)

    Pikuz, Tatiana A; Faenov, Anatoly Ya; Fukuda, Yuji; Kando, Masaki; Bolton, Paul; Mitrofanov, Alexander; Vinogradov, Alexander V; Nagasono, Mitsuru; Ohashi, Haruhiko; Yabashi, Makina; Tono, Kensuke; Senba, Yasunori; Togashi, Tadashi; Ishikawa, Tetsuya


    LiF crystal and film detectors were used to measure the far-field fluence profile of a self-amplified spontaneous-emission free-electron laser beam and diffraction imaging with high spatial resolution. In these measurements the photoluminescence (PL) response of LiF crystal and film was compared over a wide range of soft x-ray fluences. It was found that the soft x-ray fluence dependences of LiF crystal and film differ. At low fluence, the LiF crystal shows higher PL response compared to LiF film, while this comparison is the opposite at higher fluence. Accurate measurement of LiF crystal and film PL response is important for precise characterization of the spatial, spectral, and coherence features of x-ray beams across the full profile and in localized areas. For such measurements, crucial LiF detector attributes are high spatial resolution and high dynamic range.

  17. Fast, wide-field and distortion-free telescope with curved detectors for surveys at ultralow surface brightness. (United States)