WorldWideScience

Sample records for western-central songpan-ganzi-bayan har

  1. Chloroplast DNA variation of oaks in western Central Europe and genetic consequences of human influences

    NARCIS (Netherlands)

    König, A.O.; Ziegenhagen, B.; Dam, van B.C.; Csaikl, U.M.; Coart, E.; Degen, B.; Burg, K.; Vries, de S.M.G.; Petit, R.J.

    2002-01-01

    Oak chloroplast DNA (cpDNA) variation was studied in a grid-based inventory in western Central Europe, including Belgium, The Netherlands, Luxembourg, Germany, the Czech Republic, and the northern parts of Upper and Lower Austria. A total of 2155 trees representing 426 populations of Quercus robur

  2. Porphyry copper assessment of western Central Asia: Chapter N in Global mineral resource assessment

    Science.gov (United States)

    Berger, Byron R.; Mars, John L.; Denning, Paul D.; Phillips, Jeffrey D.; Hammarstrom, Jane M.; Zientek, Michael L.; Dicken, Connie L.; Drew, Lawrence J.; with contributions from Alexeiev, Dmitriy; Seltmann, Reimar; Herrington, Richard J.

    2014-01-01

    The U.S. Geological Survey conducted an assessment of resources associated with porphyry copper deposits in the western Central Asia countries of Kyrgyzstan, Uzbekistan, Kazakhstan, and Tajikistan and the southern Urals of Kazakhstan and Russia as part of a global mineral resource assessment. The purpose of the study was to (1) delineate permissive areas (tracts) for undiscovered porphyry copper deposits; (2) compile a database of known porphyry copper deposits and significant prospects; (3) where data permit, estimate numbers of undiscovered deposits within those permissive tracts; and (4) provide probabilistic estimates the amounts of copper (Cu), molybdenum (Mo), gold (Au), and silver (Ag) that could be contained in those undiscovered deposits.

  3. Kumar, Prof. Har Darshan

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1975 Section: Plant Sciences. Kumar, Prof. Har Darshan Ph.D. (London), FNA, FNASc. Date of birth: 25 February 1934. Specialization: Algology, Microbial Biotechnology, Genetics, Ecology and Environment Address: Mrigtrishna, B.32/32, H.K. 214, Saketnagar Colony, Naria, Varanasi 221 005, U.P.

  4. Har Gobind Khorana

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 17; Issue 12. Har Gobind Khorana - Early Years in Science and Transition from Chemistry to Chemical Biology. Uttam L Rajbhandary. General Article Volume 17 Issue 12 December 2012 pp 1125-1135 ...

  5. Khorana, Prof. Har Gobind

    Indian Academy of Sciences (India)

    Elected: 1976 Honorary. Khorana, Prof. Har Gobind Nobel Laureate (Medicine) - 1968. Date of birth: 9 January 1922. Date of death: 9 November 2011. Last known address: Alfred P. Sloan Professor of, Biology and Chemistry, Massachusetts Institute of, Technology, 77 Massachusetts Ave., Cambridge, MA 02139, U.S.A..

  6. Origins and genetic diversity of pygmy hunter-gatherers from Western Central Africa.

    Science.gov (United States)

    Verdu, Paul; Austerlitz, Frederic; Estoup, Arnaud; Vitalis, Renaud; Georges, Myriam; Théry, Sylvain; Froment, Alain; Le Bomin, Sylvie; Gessain, Antoine; Hombert, Jean-Marie; Van der Veen, Lolke; Quintana-Murci, Lluis; Bahuchet, Serge; Heyer, Evelyne

    2009-02-24

    Central Africa is currently peopled by numerous sedentary agriculturalist populations neighboring the largest group of mobile hunter-gatherers, the Pygmies [1-3]. Although archeological remains attest to Homo sapiens' presence in the Congo Basin for at least 30,000 years, the demographic history of these groups, including divergence and admixture, remains widely unknown [4-6]. Moreover, it is still debated whether common history or convergent adaptation to a forest environment resulted in the short stature characterizing the pygmies [2, 7]. We genotyped 604 individuals at 28 autosomal tetranucleotide microsatellite loci in 12 nonpygmy and 9 neighboring pygmy populations. We found a high level of genetic heterogeneity among Western Central African pygmies, as well as evidence of heterogeneous levels of asymmetrical gene flow from nonpygmies to pygmies, consistent with the variable sociocultural barriers against intermarriages. Using approximate Bayesian computation (ABC) methods [8], we compared several historical scenarios. The most likely points toward a unique ancestral pygmy population that diversified approximately 2800 years ago, contemporarily with the Neolithic expansion of nonpygmy agriculturalists [9, 10]. Our results show that recent isolation, genetic drift, and heterogeneous admixture enabled a rapid and substantial genetic differentiation among Western Central African pygmies. Such an admixture pattern is consistent with the various sociocultural behaviors related to intermariages between pygmies and nonpygmies.

  7. Dine marker har DNA

    DEFF Research Database (Denmark)

    Eckholdt, Annette; Winding, Anne; Krogh, Paul Henning

    2017-01-01

    Ordet "biodiversitet" og at det er noget, vi skal have mere af, nævnes hyppigt. Men hvad er biodiversitet, og hvordan måles det? Agrologisk har bedt et par eksperter fra Aarhus Universitet forklare, hvordan et DNA-aftryk af jord og vand kan erstatte optællinger i felten og sige noget om biodivers......Ordet "biodiversitet" og at det er noget, vi skal have mere af, nævnes hyppigt. Men hvad er biodiversitet, og hvordan måles det? Agrologisk har bedt et par eksperter fra Aarhus Universitet forklare, hvordan et DNA-aftryk af jord og vand kan erstatte optællinger i felten og sige noget om...

  8. Harnessing solar heat

    CERN Document Server

    Norton, Brian

    2013-01-01

    Systems engineered by man to harness solar heat in a controlled manner now include a diverse range of technologies each serving distinctive needs in particular climate contexts. This text covers the breadth of solar energy technologies for the conversion of solar energy to provide heat, either as the directly-used output or as an intermediary to other uses such as power generation or cooling. It is a wholly updated, extended and revised version of “Solar Energy Thermal Technology” first published in 1992. The text draws on the own author’s research and that of numerous colleagues and

  9. Harnessing our very life.

    Science.gov (United States)

    Wills, Peter R; Williams, David L F; Trussell, Denys; Mann, L R B

    2013-01-01

    The Aristotelian ideas of nature (physis) and technology (techné) are taken as a starting point for understanding what it would mean for technology to be truly living. Heidegger's critique of the conflation of scientific and technological thinking in the current era is accepted as demonstrating that humanity does not have a deep enough appreciation of the nature of life to harness its essence safely. Could the vision of harnessing life be realized, which we strongly doubt, living technology would give selected humans transforming powers that could be expected to exacerbate, rather than solve, current global problems. The source of human purposefulness, and hence of both technology and ethics, is identified in nature's emergent capability to instantiate informational representations in material forms. Ethics that are properly grounded in an appreciation of intrinsic value, especially that of life, demand that proposals to give humanity the capabilities of living technology address the social, political, economic, and environmental problems inherent in its development and potential deployment. Before any development is embarked on, steps must be taken to avoid living technology, whatever the term eventually designates, becoming available for destructive or antisocial purposes such as those that might devastate humanity or irrevocably damage the natural world.

  10. HARNESSING BIG DATA VOLUMES

    Directory of Open Access Journals (Sweden)

    Bogdan DINU

    2014-04-01

    Full Text Available Big Data can revolutionize humanity. Hidden within the huge amounts and variety of the data we are creating we may find information, facts, social insights and benchmarks that were once virtually impossible to find or were simply inexistent. Large volumes of data allow organizations to tap in real time the full potential of all the internal or external information they possess. Big data calls for quick decisions and innovative ways to assist customers and the society as a whole. Big data platforms and product portfolio will help customers harness to the full the value of big data volumes. This paper deals with technical and technological issues related to handling big data volumes in the Big Data environment.

  11. Composition, provenance and source weathering of Mesozoic sandstones from Western-Central Mediterranean Alpine Chains

    Science.gov (United States)

    Perri, F.

    2014-03-01

    Forty-two Mesozoic sandstone samples from three different sedimentary successions of the Internal Domains along the Western-Central Mediterranean Alpine Chains (Betic Cordillera, Rif Chain and Calabria-Peloritani Arc) were chemically analyzed to characterize their composition and the degree of weathering in the source area(s). The Rif Chain sandstones have SiO2 contents higher than those of the Calabria-Peloritani Arc and Betic Cordillera sandstones, whereas Al2O3 contents are higher in the Calabria-Peloritani Arc sandstones rather than in the Rif Chain and Betic Cordillera sandstones. The indices of compositional variability (ICV) of the studied samples are generally less than 1, suggesting that the samples are compositionally mature and were likely dominated by recycling. Recycling processes are also shown by the Al-Zr-Ti diagram indicating zircon addition and, thus, recycling processes. The Chemical Index of Alteration (CIA) values are quite homogeneous for the Calabria-Peloritani Arc (mean = 76) and Betic Cordillera sandstones (mean = 55), whereas the Rif Chain sandstones are characterized by CIA values ranging from 54 to 76. The CIW and PIA values are high for all the studied sandstones indicating intense weathering at the source areas. The different values of weathering rates among the studied sandstones may be related to variations of paleoclimatic conditions during the Mesozoic, that further favored recycling processes. Thus, these differences among the studied samples, may be related to an increase in continental palaeoweathering conditions and sediment recycling effects from the Middle Triassic to the earliest Jurassic due to rising humidity. In addition, regional tectonic movements promoted structural changes that allowed sedimentary recycling and subsidence, which in turn caused diagenetic K-metasomatism. These processes could significantly affect the CIW and PIA weathering indices, which likely monitor a cumulative effect, including several cycles of

  12. Steller sea lion satellite telemetry data used to determine at-sea distribution in the western-central Aleutian Islands, 2000-2013

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset was used for an analysis of the at-sea distribution of Steller sea lions in the western-central Aleutian Islands, Alaska. This analysis was prepared to...

  13. Harnessing off-target effects

    DEFF Research Database (Denmark)

    Saginc, Gaye; Voellmy, Franziska; Linding, Rune

    2017-01-01

    The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action.......The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action....

  14. Har vi brug for hovedregning?

    DEFF Research Database (Denmark)

    Ejersbo, Lisser Rye

    2015-01-01

    Hvor ofte har vi brug for at regne noget i hoved? Har de fleste af os ikke altid et elektronisk hjælpemiddel ved hånden enten som en lille lommeregner eller telefonen? Selvom det umiddelbart kan synes unødvendigt at træne hovedregning, viser det sig, at netop træning af hovedregning støtter...... udvikling af hurtige regnestrategier, hvorfor det faktisk er en god ide at investere tid og energi i at træne netop dette....

  15. Harnessing Aquatic Physicochemical Parameters Influencing ...

    African Journals Online (AJOL)

    The management-oriented background for harnessing aquatic physicochemical parameters influencing macro invertebrate fauna of Anambra River basin for sustainable fish productivity was studied. The intra seasonal variability in the water quality of the river revealed mean transparency of 1.79 cm, Conductivity of 28.81 ...

  16. HARNESSING INNOVATION POTENTIAL OF CROWDSOURCING

    OpenAIRE

    Slavica ROCHESKA; Marjan ANGELESKI; Dimitar NIKOLOSKI; Gjorgji MANCHESKI

    2014-01-01

    The new innovation paradigm is based upon articulation of external and internal sources of innovation. Nowadays, crowdsourcing is coming up as significant external source in innovation processes of the companies. Crowdsourcing enables harnessing of initiatives, ideas, solutions and knowledge of the crowd so as to enhance innovation performance and induce a value creation. Given that existing innovation literature does not cover sufficiently the issues related to crowdsourcing this paper is to...

  17. Alle har en historie, IV

    DEFF Research Database (Denmark)

    Ydegaard, Torbjørn

    Alle har en historie IV: Pædagogik med Freedom Writers lader et væld af pædagogiske facetter udspringe af den kendte skole-film Freedom Writers’ scener og handlinger. Der er både fokus på en almen tilgang til pædagogik og på Freedom Writer-metodikken, dels gennem de filmscener, der sættes til...

  18. Harness processes and harmonic crystals

    OpenAIRE

    Ferrari, Pablo A.; Niederhauser, Beat M.

    2003-01-01

    In the Hammersley harness processes the real-valued height at each site i in Z^d is updated at rate 1 to an average of the neighboring heights plus a centered random variable (the noise). We construct the process "a la Harris" simultaneously for all times and boxes contained in Z^d. With this representation we compute covariances and show L^2 and almost sure time and space convergence of the process. In particular, the process started from the flat configuration and viewed from the height at ...

  19. HARNESSING INNOVATION POTENTIAL OF CROWDSOURCING

    Directory of Open Access Journals (Sweden)

    Slavica ROCHESKA

    2014-05-01

    Full Text Available The new innovation paradigm is based upon articulation of external and internal sources of innovation. Nowadays, crowdsourcing is coming up as significant external source in innovation processes of the companies. Crowdsourcing enables harnessing of initiatives, ideas, solutions and knowledge of the crowd so as to enhance innovation performance and induce a value creation. Given that existing innovation literature does not cover sufficiently the issues related to crowdsourcing this paper is to offer an additional views about innovation potentials of crowdsourcing thus contributing for future research on this relatively unexplored concept. Therefore, this paper aims at considering key insights about crowdsourcing contribution on developing companies’ innovation capacity. More specifically it is focused on identification of benefits, weaknesses and risks arising from crowdsourcing to the innovation process comprising conceptual and empirical aspects.

  20. Western Central Asia - Uzbekistan:new insights into the basin architecture and lithosphere structures from geophysical data

    Science.gov (United States)

    Sidorova, Irina

    2014-05-01

    This report was prepared as one part of joint Uzbekistan's Working Group results by DARIUS programme, provided in Uzbekistan during the 2009-2013 years. The special attention is devoted to potential geophysical fields and results of interpretation of seismic profiles, which was the base for conclusions about deep lithosphere structure of the DARIUS domains in Uzbekistan.For four last years 12 field expeditions in Uzbekistan were organized by the DARIUS projects - were studied new geological sections and now the new ideas developing about geodynamical evolution in Western Central Asia. The state of art reveals a very heterogeneous set of data. These data commonly deal either with particular basins or mountain belts, or specific basin investigations. Our aim was to combine all available seismic, magnetic and geothermal data with the revealed of the tectonically objects, geological structures, and to show their interrelated temporal and spatial development for general understanding of the inner structure of lithosphere and upper layers of Earth's crust. In link of this, the detailed studying structure of Paleozoic crystal basement on representative basic sites and the crossing faults, accompained by drawing up of level-by-level and summary sections, large-scale geological and geophysical mapping was conducted. Our study elucidated the lithosphere-scale processes driving forces for kinematic of blocks between southern Tien Shan and Pamir. All our data were integrated in the DARIUS database GEOLIS.

  1. Har du rådne kunder?

    DEFF Research Database (Denmark)

    Grünbaum, Niels Nolsøe

    2015-01-01

    Tætte kunderelationer er ikke altid guld værd. Har du modet til at skille dig af med kunder, som ødelægger din forretning?......Tætte kunderelationer er ikke altid guld værd. Har du modet til at skille dig af med kunder, som ødelægger din forretning?...

  2. 14 CFR 91.521 - Shoulder harness.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Shoulder harness. 91.521 Section 91.521 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC... Airplanes and Fractional Ownership Program Aircraft § 91.521 Shoulder harness. (a) No person may operate a...

  3. Epidemiology of tick-borne encephalitis (TBE) in international travellers to Western/Central Europe and conclusions on vaccination recommendations.

    Science.gov (United States)

    Steffen, Robert

    2016-04-01

    Tick-borne encephalitis (TBE) endemicity is spreading in Europe becoming an increasing health risk also for travellers. Previous reviews on TBE in civilian travellers lacked of numerator data and offered at most rough estimates on denominator data. An evidence-based quantification of the risk so far has been impossible; that resulted in fundamentally differing vaccination recommendations. A standard internet search was conducted with a focus on the data used to formulate vaccination recommendations. As TBE became notifiable at the European Union (EU) level the databases of European Center for Disease Prevention and Control (ECDC) were analysed for cases imported from abroad 2012. Since these included only 19 EU countries, individual experts were contacted in countries, which had not submitted data and additional surveillance databases were investigated to obtain a comprehensive account on travel-associated TBE in Central and Western Europe. In 2012, the ECDC and other data sources included 38 reported cases of internationally acquired TBE. Basing on estimates of the exposed number of visitors, the attack rate for an undefined period of time could be very roughly extrapolated to be 0.5-1.3 per 100,000 (1 per 77,000-200.000) overall in Western/Central Europe endemic areas for the exposed at-risk population. As advised by the World Health Organization (WHO) travellers exposed outdoors in rural endemic areas to a risk of TBE during the period of transmission should be recommended immunization. In contrast, the advice to recommend TBE vaccination for all visitors of endemic areas is inappropriate. Implementation of the risk strategy is compromised by the fact that many at-risk travellers are unaware of the risk, thus they will not consult competent health professionals. Others may consult late, and in some countries of origin no TBE vaccine is marketed. © International Society of Travel Medicine, 2016. All rights reserved. Published by Oxford University Press. For

  4. Ambulatory purchasing: harnessing supply costs.

    Science.gov (United States)

    Jager, P A

    1997-04-01

    The healthcare system remains in a dynamic state of flux. We have all heard the story: the changing healthcare market brings reduced reimbursement for services, increased competition, and steadily increasing supply, maintenance, and equipment costs. Ambulatory surgery centers (ASCs) must keep in sync with this change or fail to survive the current market forces. However, because they represent a small contract to various vendors, many ASCs pay premium prices for inventory while receiving less from Managed Care Plans (MCPs) and Health Maintenance Organizations (HMOs). This dilemma makes control of supply costs a top priority for ASCs. In reality, purchasing is becoming more strategically connected to the ASC balance sheet than ever before. Apart from personnel costs, supply and pharmaceutical purchasing represents the greatest expense category on our financial statement. Harnessing these costs directly relates to bottom line profitability. In addition, while performing cost savings magic, ASCs must maintain patient and surgeon satisfaction with the superior outcomes and state-of-the-art technology their reputations are based upon. Sound impossible? This article details how Surgery Center Plus, Inc. (SCP) implemented a cost containment project.

  5. Mesozoic and Eocene ductile deformation of western Central Iran: from Cimmerian collisional orogeny to Eocene extension and exhumation

    Science.gov (United States)

    Kargaranbafghi, Fariba; Neubauer, Franz; Genser, Johann

    2010-05-01

    To advance our understanding of the Mesozoic to Eocene tectonics and kinematics of basement units exposed in the south-western Central Iran plateau, this paper presents new structural and thermochronological data from the Chapedony metamorphic core complex and hangingwall units, particularly from the Posht-e-Badam complex. The overall Paleogene structural characteristics of the area are related to an oblique convergent zone. The Saghand area represent part of a deformation zone between the Arabia and Eurasia plates, and can be interpreted as a product of the Central Iran intracontinental deformation as a weak zone during Mesozoic to Paleogene times. Field and microstructural evidence reveals that the metamorphic and igneous rocks in the study area suffered a ductile shear deformation including mylonitization at the hangingwall boundary of the Eocene Chapedony metamorphic core complex. The shear zone is subhorizontal low-angle normal fault and the shear direction of the hangingwall unit is towards NE, based on the attitude of foliation and lineation of ductility deformed rocks and shear sense indicators. Comparison of deformation features in the described mylonites and other structural features within the footwall unit lead to the conclusion that the mylonites were formed in a subhorizontal shear zone by NE-SW stretching in the extension tectonics during Middle to Late Eocene. The Chapedony metamorphic core complex is characterized by amphibolite-facies metamorphism and development of S and S-L tectonic fabrics. The Posht-e-Badam complex is deformed by two stages during Cimmerian tectonic processes forming the Paleo-Tethyan suture. The Posht-e-Badam complex is overprinted by two stages of metamorphism. White mica ages at 203 and 181 Ma are related to cooling after medium-grade metamorphism respectively ductile shearing. These ages are variably overprinted by low-grade metamorphism also affecting Jurassic metasediments in the Polo area. Consequently, these are

  6. Design Process Improvement for Electric CAR Harness

    Science.gov (United States)

    Sawatdee, Thiwarat; Chutima, Parames

    2017-06-01

    In an automobile parts design company, the customer satisfaction is one of the most important factors for product design. Therefore, the company employs all means to focus its product design process based on the various requirements of customers resulting in high number of design changes. The objective of this research is to improve the design process of the electric car harness that effects the production scheduling by using Fault Tree Analysis (FTA) and Failure Mode and Effect Analysis (FMEA) as the main tools. FTA is employed for root cause analysis and FMEA is used to ranking a High Risk Priority Number (RPN) which is shows the priority of factors in the electric car harness that have high impact to the design of the electric car harness. After the implementation, the improvements are realized significantly since the number of design change is reduced from 0.26% to 0.08%.

  7. Medicinalindustrien har brug for diagnoser som ADHD

    DEFF Research Database (Denmark)

    Fugl, Marie

    2008-01-01

    Det er ikke første gang, at medicinalindustriens evne til at finde nye markeder har medført nye eller bredere diagnoser. I det forrige årti så vi et parallelt forløb mellem et boom i antallet af depressionsdiagnoser og forbruget af lykkepiller. Interview med sociolog Thomas Brante. Udgivelsesdato...

  8. Økonomer har et forklaringsproblem

    DEFF Research Database (Denmark)

    Rangvid, Jesper

    2016-01-01

    Markederne toppede i april/maj 2015 og har haft det svært siden. Meget tyder 2016 er startet med voldsomme fald på de globale aktiemarkeder. Det er muligvis med rette for nogle banker, men overordnet er sektoren mere robust, ikke mindst grundet bedre regulering, end før finanskrisen i 2008...

  9. SRB Altitude Switch Assembly Wire Harness Failure

    Science.gov (United States)

    Blanche, Jim

    2002-01-01

    This paper presents an assessment of two wire harness failures that had occurred in Solid Rocket Booster Altitude Switch Assemblies S/N 200001 and S/N 20002. A list of modifications to EDU #4 and modification of qualification units 2000001 and 2000002 are also presented.

  10. Kyllinger har effektivt immunforsvar mod herpes

    DEFF Research Database (Denmark)

    Buchmann, Kurt

    2008-01-01

    Forskere ved Københavns Universitet, Fakultet for Biovidenskab har studeret kyllingens MHC molekyler og kan derigennem forklare hvorfor en særlig stamme indenfor denne art er modstandsdygtige mod en særlig herpesvirus. Udgivelsesdato: 18. januar 2008...

  11. Harness Traction Technique (HARNESS): Novel Method for Controlling the Transection Plane During Laparoscopic Hepatectomy.

    Science.gov (United States)

    Itano, Osamu; Oshima, Go; Kitago, Minoru; Suzuki, Keiichi; Hayatsu, Shigeo; Shinoda, Masahiro; Abe, Yuta; Hibi, Taizo; Yagi, Hiroshi; Ikoma, Naruhiko; Aiko, Satoshi; Kitagawa, Yuko

    2015-08-01

    We present our experience using a novel method for controlling the transection plane, which we termed as the Harness Traction Technique (HARNESS) and evaluate its usefulness. From May 2009 to March 2012, laparoscopic hepatectomies using HARNESS were performed on 35 patients. After the superficial hepatic parenchyma on the line was transected at 1 to 2 cm depth, 5 mm tape was placed along the groove of the line and tied to prevent it from slipping off. Tape was tied and pulled using a forceps toward the best direction for minimizing the bleeding, moving the transection point to the appropriate position and creating good tension for parenchymal transection at the transection point. There were no conversions to laparotomy or intraoperative complications. HARNESS is useful for controlling the dissection line during laparoscopic hepatectomy, leading to precise and safe laparoscopic liver parenchymal dissection.

  12. Dry Electrode Harness System For Wireless 12-LEAD ECG Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The dry-electrode harness is composed of a variety of components.  The harness interfaces with the human via a commercial-off-the-shelf (COTS) FDA cleared dry...

  13. Harnessing the wisdom of the inner crowd.

    Science.gov (United States)

    Herzog, Stefan M; Hertwig, Ralph

    2014-10-01

    Ever since Galton's classic demonstration of the wisdom of crowds in estimating the weight of a slaughtered ox, scholars of the mind and the public alike have been fascinated by the counterintuitive accuracy achieved by simply averaging a number of people's estimates. Surprisingly, individuals can, to some extent, harness the wisdom of crowds within the confines of their own mind by averaging self-generated, nonredundant estimates. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Health disparities among the western, central and eastern rural regions of China after a decade of health promotion and disease prevention programming.

    Science.gov (United States)

    Zhang, Xi-Fan; Tian, Xiang-Yang; Cheng, Yu-Lan; Feng, Zhan-Chun; Wang, Liang; Southerland, Jodi

    2015-08-01

    Health disparities between the western, central and eastern regions of rural China, and the impact of national health improvement policies and programming were assessed. A total of 400 counties were randomly sampled. ANOVA and Logistic regression modeling were employed to estimate differences in health outcomes and determinants. Significant differences were found between the western, central and eastern rural regions in community infrastructure and health outcomes. From 2000 to 2010, health indicators in rural China were improved significantly, and the infant mortality rate (IMR), maternal mortality rate (MMR) and under 5 mortality rate (U5MR) had fallen by 62.79%, 71.74% and 61.92%, respectively. Central rural China had the greatest decrease in IMR (65.05%); whereas, western rural China had the greatest reduction in MMR (72.99%) but smallest reduction in U5MR (57.36%). Despite these improvements, Logistic regression analysis showed regional differences in key health outcome indicators (odds ratios): IMR (central: 2.13; western: 5.31), U5MR (central: 2.25; western: 5.69), MMR (central: 1.94; western: 3.31), and prevalence of infectious diseases (central: 1.62; western: 3.58). The community infrastructure and health outcomes of the western and central rural regions of China have been improved markedly during the first decade of the 21st century. However, health disparities still exist across the three regions. National efforts to increase per capita income, community empowerment and mobilization, community infrastructure, capacity of rural health facilities, and health literacy would be effective policy options to attain health equity.

  15. Behavior of sandhill cranes harnessed with different satellite transmitters

    Science.gov (United States)

    Olsen, Glenn H.; Ellis, D.H.; Landfried, S.E.; Miller, L.H.; Klugman, S.S.; Fuller, M.R.; Vermillion, C.H.

    1992-01-01

    The effectiveness of various attachment methods and designs of platform transmitting terminals (PTT's) was tested on captive sandhill cranes (Grus canadensis) at the Patuxent Wildlife Research Center, Laurel, Maryland, during 1989-91. Combinations of attachment and transmitter designs included neoprene cord harness with batteries separate from the transmitter (2 harness designs), Teflon ribbon harness with batteries incorporated into the transmitter package (4 transmitter models), and a package attached directly to the bird with epoxy glue only. Physical effects seen on cranes wearing PTT's ranged from skin lacerations (caused by rubbing of harness material) to no observed effects (other than feather wear). The most successful harness material and design utilized a Teflon ribbon harness with the 4 ribbon ends from the transmitter forming a neck loop and a body loop joined at the sternum. Time spent by sandhill cranes performing most activities did not change after transmitter attachment using this harness method.

  16. Harnessing the Microbiome to Enhance Cancer Immunotherapy

    Directory of Open Access Journals (Sweden)

    Michelle H. Nelson

    2015-01-01

    Full Text Available The microbiota plays a key role in regulating the innate and adaptive immune system. Herein, we review the immunological aspects of the microbiota in tumor immunity in mice and man, with a focus on toll-like receptor (TLR agonists, vaccines, checkpoint modulators, chemotherapy, and adoptive T cell transfer (ACT therapies. We propose innovative treatments that may safely harness the microbiota to enhance T cell-based therapies in cancer patients. Finally, we highlight recent developments in tumor immunotherapy, particularly novel ways to modulate the microbiome and memory T cell responses to human malignancies.

  17. The serial harness interacting with a wall

    OpenAIRE

    Ferrari, P. A.; Fontes, L. R. G.; Niederhauser, B.; Vachkovskaia, M.

    2002-01-01

    The serial harnesses introduced by Hammersley describe the motion of a hypersurface of dimension d embedded in a space of dimension $d+1$. The height assigned to each site i of Z^d is updated by taking a weighted average of the heights of some of the neighbors of i plus a ``noise'' (a centered random variable). The surface interacts by exclusion with a ``wall'' located at level zero: the updated heights are not allowed to go below zero. We show that for any distribution of the noise variables...

  18. Harnessing the Properties of Natural Products.

    Science.gov (United States)

    Boufridi, Asmaa; Quinn, Ronald J

    2018-01-06

    Natural products (NPs) have been used as traditional medicines since antiquity. With more than 10 60 estimated compounds with molecular weights less than 500 Da representing chemical space, NPs occupy a very small percentage; however, they are significantly overrepresented in biologically relevant chemical space. The classical approach concentrates on identifying one or more NPs with biological activity from a source organism. There is much more to be learned from NPs than we can discover this narrow view. In this review, we discuss ways to harness the global properties of NPs.

  19. Hvordan har jeg det i dag?

    DEFF Research Database (Denmark)

    Kappelgaard, Lisbeth

    stress. En central problemstilling er her at stress er ’vanskeligt at tage i opløbet’. Med afsæt i denne problemstilling udvikles metoden Ecological Momentary storytelling (EMS) - en metode, der ved hjælp af ’ecological momentary assessments’ og refleksive dialoger anvendes til at ’spore’ stressorer i...... casestudie, hvor kliniske møder mellem patient og sundhedsprofessionelle gøres til genstand for interaktionsanalyse. Herigennem tilvejebringes indblik i, hvilke udfordringer der kan være forbundet med selvmonitoreringspraksis, når man har Sundhedsstyrelsens ønsker og forventninger som udgangspunkt....

  20. Suspension tolerance in a full-body safety harness, and a prototype harness accessory.

    Science.gov (United States)

    Turner, Nina L; Wassell, James T; Whisler, Richard; Zwiener, Joyce

    2008-04-01

    Workers wearing full-body safety harnesses are at risk for suspension trauma if they are not rescued in 5 to 30 min after a successfully arrested fall. Suspension trauma, which may be fatal, occurs when a person's legs are immobile in a vertical posture, leading to the pooling of blood in the legs, pelvis, and abdomen, and the reduction of return blood flow to the heart and brain. To measure suspension tolerance time, 22 men and 18 women with construction experience were suspended from the chest D-ring (CHEST) and back D-ring (BACK) of full-body, fall-arrest harnesses. Fifteen men and 13 women from the original group of subjects were then suspended using a newly developed National Institute for Occupational Safety and Health harness accessory (ACCESS), which supports the upper legs. Midthigh circumference changes were 1.4 and 1.9 cm, changes in minute ventilation were 1.2 and 1.5 L/min, changes in heart rate (HR) were 15.1 and 21.6 bpm, and changes in mean arterial pressure were 5.1 and -2.6 mmHg (p harness accessory to delay or prevent suspension trauma.

  1. Mitochondrial DNA Variation Reveals a Sharp Genetic Break within the Distribution of the Blue Land Crab Cardisoma guanhumi in the Western Central Atlantic

    Directory of Open Access Journals (Sweden)

    Maria Rosimere Xavier Amaral

    2015-08-01

    Full Text Available The blue land crab Cardisoma guanhumi is widely distributed throughout tropical and subtropical estuarine regions in the Western Central Atlantic (WCA. Patterns of population genetic structure and historical demographics of the species were assessed by mtDNA control region sequence analysis to examine the connectivity among five populations (n = 97 within the region for future conservation strategies and decision-making of fishery management. A total of 234 polymorphic nucleotides were revealed within the sequence region, which have defined 93 distinct haplotypes. No dominant mtDNA haplotypes were found but instead a distribution of a few low-frequency recurrent haplotypes with a large number of singletons. A NJ-tree and a median-joining haplotype network revealed two distinct clusters, corresponding to individuals from estuaries located along the Caribbean Sea and Brazilian waters, respectively. AMOVA and FST statistics supported the hypothesis that two main geographic regions exists. Phylogeographical discontinuity was further demonstrated by the Bayesian assignment analysis and a significant pattern of isolation-by-distance. Additionally, tests of neutral evolution and analysis of mismatch distribution indicate a complex demographic history in the WCA, which corresponds to bottleneck and subsequent population growth. Overall, a sharp genetic break between Caribbean and Brazilian populations raised concerns over the conservation status of the blue land crab.

  2. Harnessing supramolecular peptide nanotechnology in biomedical applications.

    Science.gov (United States)

    Chan, Kiat Hwa; Lee, Wei Hao; Zhuo, Shuangmu; Ni, Ming

    2017-01-01

    The harnessing of peptides in biomedical applications is a recent hot topic. This arises mainly from the general biocompatibility of peptides, as well as from the ease of tunability of peptide structure to engineer desired properties. The ease of progression from laboratory testing to clinical trials is evident from the plethora of examples available. In this review, we compare and contrast how three distinct self-assembled peptide nanostructures possess different functions. We have 1) nanofibrils in biomaterials that can interact with cells, 2) nanoparticles that can traverse the bloodstream to deliver its payload and also be bioimaged, and 3) nanotubes that can serve as cross-membrane conduits and as a template for nanowire formation. Through this review, we aim to illustrate how various peptides, in their various self-assembled nanostructures, possess great promise in a wide range of biomedical applications and what more can be expected.

  3. A KBE Application for Automatic Aircraft Wire Harness Routing

    NARCIS (Netherlands)

    Zhu, Z.; Van Tooren, M.J.L.; La Rocca, G.

    2012-01-01

    Wire harness design is an increasingly complex task. Knowledge Based Engineering (KBE) and optimization techniques can be used to support designers in handling this complexity. The wire harness design process can be divided in three main parts, namely electrical design, configuration design and

  4. Canyon incision chronology based on ignimbrite stratigraphy and cut-and-fill sediment sequences in SW Peru documents intermittent uplift of the western Central Andes

    Science.gov (United States)

    Thouret, Jean-Claude; Gunnell, Yanni; Jicha, Brian R.; Paquette, Jean-Louis; Braucher, Régis

    2017-12-01

    Based on an 40Ar/39Ar- and U/Pb-based chronostratigraphy of ignimbrite sheets and the geomorphological features of watersheds, river profiles and slope deposits in the Ocoña-Cotahuasi-Marán (OCM) and Colca valleys of southwest Peru, we reconstruct the valley incision history of the western Central Andes over the last c. 25 Myr. We further document the Pleistocene and Holocene evolution of deep valleys on the basis of 14 10Be surface-exposure ages obtained on debris-avalanche deposits and river straths. The data suggest that uplift was gradual over the past 25 Myr, but accelerated after c. 9 Ma. Valley incision started around 11-9 Ma and accelerated between 5 and 4 Ma. Incision was followed by several pulses of valley cut-and-fill after 2.3 Ma. Evidence presented suggest that the post-5 Ma sequence of accelerated canyon incision probably resulted from a combination of drainage piracy from the Cordilleran drainage divide towards the Altiplano, accentuated flexural tilting of the Western Cordillera towards the SE, and increased rainfall on the Altiplano after late Miocene uplift of the Eastern Cordillera. The valley deepening and slope steepening driven by tectonic uplift gave rise to large occurrences of rockslope failure. The collapsed rock masses periodically obstructed the canyons, thus causing abrupt changes in local base levels and interfering with the steadiness of fluvial incision. As a result, channel aggradation has prevailed in the lower-gradient, U-shaped Pacific-rim canyons, whereas re-incision through landslide deposits has occurred more rapidly across the steeper V-shaped, upper valleys. Existing canyon knickpoints are currently arrested at the boundary between the plutonic bedrock and widespread outcrops of middle Miocene ignimbritic caprock, where groundwater sapping favouring rock collapse may be the dominant process driving headward erosion.

  5. Registration of two confection sunflower germplasm Lines, HA-R10 and HA-R11, Resistant to sunflower rust

    Science.gov (United States)

    Two confection sunflower (Helianthus annuus L.) germplasm lines, HA-R10 (Reg. No.xxx, PI670043) and HA-R11 (Reg. No.xxx, PI670044) were developed by the USDA-ARS Sunflower and Plant Biology Research Unit in collaboration with the North Dakota Agricultural Experiment Station and released December, 20...

  6. Registration of two double rust resistant germplasms, HA-R12 and HA-R13 for confection sunflower

    Science.gov (United States)

    The confection sunflower (Helianthus annuus L.) germplasms HA-R12 (Reg. No. ______, PI 673104) and HA-R13 (Reg. No. ______, PI 673105) were developed by the USDA-ARS, Sunflower and Plant Biology Research Unit in collaboration with the North Dakota Agricultural Experiment Station, and released in Jul...

  7. Harnessing nanomedicine for therapeutic intervention in glioblastoma.

    Science.gov (United States)

    Gutkin, Anna; Cohen, Zvi R; Peer, Dan

    2016-11-01

    Glioblastoma is a type of brain cancer arises from glial cells. Glioblastoma multiforme (GBM), a subtype of glioblastoma, is the most common and most aggressive primary brain tumor. Currently, GBM therapy includes surgery and post-operative high-doses of radiation and chemotherapy. This therapeutic strategy has a limited contribution in extending the survival rate of GBM patients. Areas covered: Herein, we focus on harnessing nanoscale drug delivery strategies to treat brain malignancies. Specifically, we briefly discuss the challenges facing GBM therapy such as restricted passage across the blood-brain barrier (BBB) and low enhanced permeability and retention effect. Next, we describe different pathways to address these challenges. Finally, we discuss the field of nanomedicine, which emerged as a promising platform for drug delivery to brain malignancies. Expert opinion: Countless strategies have been applied in preclinical and clinical settings to treat GBM. Among them is the use of different types of nanoparticles (NPs) and viruses with different approaches to cross or bypass the BBB. We suggest here a paradigm shift in thinking about crossing the BBB and tumor penetration as fundamental issues that need to be address in order to improve the therapeutic outcome in GBM.

  8. Hvor mange betydninger har et ord

    DEFF Research Database (Denmark)

    Bergenholtz, Henning; Toftgaard Madsen, August

    2017-01-01

    artikler, som August har skrevet til Den Danske Betydningsordbog: trøske, tonisk, tonnage, topskud, topstykke, toradet, tornerosesøvn, touch, trykkoger, træhammer, trøffel. Ud fra analysen af disse eksempler udleder vi følgende metodiske tese: I forbindelse med receptionsproblem laves polysemi, når et...... bestemt ord bruges i forskellige sammenhænge og refererer til forskellige ting eller handlinger. Hvis leksikografen er i tvivl om polysemi eller ej, vælges polysemi. Vi udleder to teoretiske teser: 1. Lemmaselektion og polysemiselektion er to sider af samme sag 2 Det gælder især, hvis man afskaffer...... homonymi og polysemi, sådan foreslår Bergenholtz/Agerbo (2014), så er polysemiselektion og lemmaselektion det samme. Herfor kan bruges den fælles betegnelse: artikelselektion med to metodiske skridt (1. udtryksselektion (lemmaselektion), 2. indholdsselektion, hvis et udtryk kan forbindes med mere end et...

  9. Harnessing adolescent values to motivate healthier eating.

    Science.gov (United States)

    Bryan, Christopher J; Yeager, David S; Hinojosa, Cintia P; Chabot, Aimee; Bergen, Holly; Kawamura, Mari; Steubing, Fred

    2016-09-27

    What can be done to reduce unhealthy eating among adolescents? It was hypothesized that aligning healthy eating with important and widely shared adolescent values would produce the needed motivation. A double-blind, randomized, placebo-controlled experiment with eighth graders (total n = 536) evaluated the impact of a treatment that framed healthy eating as consistent with the adolescent values of autonomy from adult control and the pursuit of social justice. Healthy eating was suggested as a way to take a stand against manipulative and unfair practices of the food industry, such as engineering junk food to make it addictive and marketing it to young children. Compared with traditional health education materials or to a non-food-related control, this treatment led eighth graders to see healthy eating as more autonomy-assertive and social justice-oriented behavior and to forgo sugary snacks and drinks in favor of healthier options a day later in an unrelated context. Public health interventions for adolescents may be more effective when they harness the motivational power of that group's existing strongly held values.

  10. SSME Electrical Harness and Cable Development and Evolution

    Science.gov (United States)

    Abrams, Russ; Heflin, Johnny; Burns, Bob; Camper, Scott J.; Hill, Arthur J.

    2010-01-01

    The Space Shuttle Main Engine (SSME) electrical harness and cable system consists of the various interconnecting devices necessary for operation of complex rocket engine functions. Thirty seven harnesses incorporate unique connectors, backshell adapters, conductors, insulation, shielding, and physical barriers for a long maintenance-free life while providing the means to satisfy performance requirements and to mitigate adverse environmental influences. The objective of this paper is to provide a description of the SSME electrical harness and cable designs as well as the development history and lessons learned.

  11. Variability and 20-Year Trends in Satellite-Derived Surface Chlorophyll Concentrations in Large Marine Ecosystems around South and Western Central America

    Directory of Open Access Journals (Sweden)

    Marina Marrari

    2017-11-01

    Full Text Available Marine ecosystems are under the increasing stress of natural and anthropogenic climate variability and change. Knowledge of the patterns of distribution of chlorophyll concentrations as an indicator of phytoplankton abundance, its spatial and temporal variability, and the processes that control this variability is required to better understand the dynamics of marine populations and their fluctuations, including species of ecological and commercial importance. The Patagonia (PLME, South Brazil (SBLME, Humboldt (HLME, and Pacific Coastal Central America (PCACLME Large Marine Ecosystems (LMEs around South and Western Central America support high primary productivity and fisheries catch. During the past few decades, climate change and warming in most ecosystems has become evident, which in combination with variations in production rates could impact the dynamics of marine ecosystems. The goal of this study is to assess the variability and longer-term trends in chlorophyll concentrations in the PLME, SBLME, HLME, and PCACLME, and to discuss implications for higher trophic levels. We use a combination of high-resolution satellite-derived chlorophyll concentration data from SeaWiFS (1997–2006 and MODIS Aqua (2002–2017 to examine spatial and temporal variability and analyze the record-length linear trends in these LMEs (25°N-60°S, 30–120°W. We use monthly composites with 2 × 2 km spatial resolution for the period of overlap between sensors (2002–2006 to compare retrievals and adjust the MODIS Aqua data series at all pixels using linear regressions. We then apply the corrections to the MODIS data and combine the SeaWiFS and adjusted MODIS datasets to generate the longest time series in chlorophyll concentrations to date in the region. Our results revealed significant increases in chlorophyll concentrations in large areas of the PLME (78.23% and HLME (43.03% during the last ~20 years, with large potential implications for trophic relationships

  12. Triple isotope (δD, δ17O, δ18O) study on precipitation, drip water and speleothem fluid inclusions for a Western Central European cave (NW Switzerland)

    Science.gov (United States)

    Affolter, Stéphane; Häuselmann, Anamaria D.; Fleitmann, Dominik; Häuselmann, Philipp; Leuenberger, Markus

    2015-11-01

    . This study on precipitation, drip water and fluid inclusions will be used as a speleothem proxy calibration for Milandre cave in order to reconstruct paleotemperatures and moisture source variations for Western Central Europe.

  13. Harnessing Earth Observations for Disaster Application Science

    Science.gov (United States)

    Green, D. S.

    2015-12-01

    Earth observations have made substantive contributions to the understanding of natural hazards, answering key science questions on the mechanisms, processes and dynamics of changes in the land, air and water. This has been achieved through the ability to advance models and interpret the results through maps and assessments. Disaster application science is focused on the two-way flow of data and information between hazard understanding and the knowledge required for disaster response, relief and recovery. This presentation will examine the integration of results from mature science and technology development in areas including optical imagery, synthetic-aperture radar and geodetic sensors, which together provide new levels of situational awareness. Specific examples will be highlighted from the recent Nepal "Gorkha" earthquake. Optical imagery from a host of satellite missions was used to create a comprehensive mosaic across the region, which when analyzed by a global network of volunteer scientists yielded insight into the extent of induced hazards and impacts. In some cases unique day/night band images provided guidance on areas where energy-dependent infrastructure of livelihoods were disrupted. Earthquake modeling and historical trend analysis revealed areas of potential vulnerability and combined with aftershock analysis to guide areas for urgent analysis and action. The combination of SAR and GPS data, innovative integration and processing approaches and nontraditional data integration approaches resulted in damage proxy maps or where combination with airborne photography, field sightings and crowd sourced reports to assess susceptibility to induced hazards (floods and landslides). Opportunities and challenges to build the science and community relationships, harness the earth observations from multiple agencies and institutions and co-develop timely applications to users will be areas for ongoing collaboration and study.Earth observations have made

  14. Har læreplanen (stadig) minimal betydning?

    DEFF Research Database (Denmark)

    Poulsen, Jens Aage

    2016-01-01

    Undervisningsministeriets læreplaner for skolens fag er centrale styredokumenter, der fastlægger formål og rammesætter indhold og form for undervisningen. Men hvilken betydning har de i praksis?...

  15. Developing a TTCN-3 Test Harness for Legacy Software

    DEFF Research Database (Denmark)

    Okika, Joseph C.; Ravn, Anders Peter; Siddalingaiah, Lokesh

    2006-01-01

    We describe a prototype test harness for an embedded system which is the control software for a modern marine diesel engine. The operations of such control software requires complete certification. We adopt Testing and Test Control Notation (TTCN-3) to define test cases for this purpose. The main...... challenge in developing the test harness is to interface a generic test driver to the legacy software and provide a suitable interface for test engineers. The main contribution of this paper is a demonstration of a suitable design for such a test harness. It includes: a TTCN-3 test driver in C++, the legacy...... control software in C, a Graphical User Interface (GUI) and the connectors in Java. Our experience shows that it is feasible to use TTCN-3 in developing a test harness for a legacy software for an embedded system, even when it involves different heterogeneous components....

  16. Army Social Media: Harnessing the Power of Networked Communications

    Science.gov (United States)

    2011-09-01

    9/1/2011 Army Social Media : harnessing the power of networked communications Report Documentation Page Form ApprovedOMB No. 0704-0188 Public...4. TITLE AND SUBTITLE Army Social Media : harnessing the power of networked communications 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...the Chief of Public Affairs,Online and Social Media Division,1500 Pentagon,Washington,DC,20301 8. PERFORMING ORGANIZATION REPORT NUMBER 9

  17. Planter har også som dyr et immunforsvar

    DEFF Research Database (Denmark)

    Buchmann, Kurt

    2007-01-01

    Planter har et system til at genkende bl.a. skadedyr og deres specifikke stoffer, hvorefter de kan aktivere en række mekanismer til at eliminere disse. Udgivelsesdato: 27. april......Planter har et system til at genkende bl.a. skadedyr og deres specifikke stoffer, hvorefter de kan aktivere en række mekanismer til at eliminere disse. Udgivelsesdato: 27. april...

  18. Pakistan: Har atomvåben stabiliseret konflikten med Indien?

    DEFF Research Database (Denmark)

    Nielsen, Thomas Galasz

    2016-01-01

    Både Pakistan og Indien har et atomvåbenprogram, men kan atomvåben stabilisere konflikten mellem de to lande? Ikke rigtigt, men våbnene har tiltrukket USA’s opmærksomhed, og det er måske den bedste mulighed for at stabilisere regionen på det strategiske niveau – om end USA reelt ikke kan hindre små...

  19. Past climate variability inferred from statistical processing of documentary data: a case study on extreme meteorological events in western central France from 1500 to 2000 AD

    Science.gov (United States)

    Poirier, Clément; Chaumillon, Eric; Audé, Jean-Luc

    2010-05-01

    Recent human-induced climate changes are expected to have an impact on extreme events including shifts in storm tracks, heavier precipitations and more severe droughts (Planton, 2008). Although climate models successfully describe the past mean climate variability, they often fail to correctly reproduce such extreme events, mainly because of a low spatial and temporal resolution (Sánchez et al., 2004). Reports of extreme meteorological events gathered from documentary archives are be useful to fill this gap, and would also provide insights into local climatic variations (Leijonhufvud et al., 2008; Rodrigo, 2008; Wheeler, 2006). In this study, a local text book published by Audé (2006) was used as a source of climatic data. It consists of a list of extreme meteorological events recorded in historical archives (diaries mainly) in western central France, along the Bay of Biscay. From the book, 284 extreme meteorological events that occurred between 1500 and 2000 were selected. A presence-absence matrix was built, the events being classified in 7 distinct categories by Audé. A preliminary multivariate analysis (Principal Component Analysis) was used to group these categories into 4 classes of events. First axis (22.3% of explained variance) discriminated the events related to temperature, with frosts and snowfalls on one side, versus gales and storms on the other side. Second axis (18.5% of explained variance) discriminated the events related to precipitation, with floods and rainfalls on one side (humid), versus droughts on the other (dry). For each class, a 29-year running mean was computed to convert binary qualitative data to semi-quantitative curves. A spectral analysis was also performed on the same binary data to detect potential climatic cycles. Despite the randomness of the historical records reported in this book, that much relies on the subjective perception of meteorological events by past witnesses, the results obtained are consistent with existing data

  20. A Key Review of Non-Industrial Greywater Heat Harnessing

    Directory of Open Access Journals (Sweden)

    Abdur Rehman Mazhar

    2018-02-01

    Full Text Available The ever-growing concerns about making buildings more energy efficient and increasing the share of renewable energy used in them, has led to the development of ultra-low carbon buildings or passive houses. However, a huge potential still exists to lower the hot water energy demand, especially by harnessing heat from waste water exiting these buildings. Reusing this heat makes buildings more energy-efficient and this source is considered as a third-generation renewable energy technology, both factors conforming to energy policies throughout the world. Based on several theoretical and experimental studies, the potential to harness non-industrial waste water is quite high. As an estimate about 3.5 kWh of energy, per person per day could be harnessed and used directly, in many applications. A promising example of such an application, are low temperature fourth generation District Heating grids, with decentralized sources of heat. At the moment, heat exchangers and heat pumps are the only viable options to harness non-industrial waste heat. Both are used at different scales and levels of the waste-water treatment hierarchical pyramid. Apart from several unfavourable characteristics of these technologies, the associated exergetic efficiencies are low, in the range of 20–50%, even when cascaded combinations of both are used. To tackle these shortcomings, several promising trends and technologies are in the pipeline, to scavenge this small-scale source of heat to a large-scale benefit.

  1. Harnessing big data to meet the Sustainable Development Goals ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Harnessing big data to meet the Sustainable Development Goals – Building capacity in the Global South. Large volumes of complex and variable data, often called big data, promise to improve government service delivery, complement official statistics, and facilitate development in sectors such as health, urban ...

  2. Manufacture and quality control of interconnecting wire harnesses, Volume 3

    Science.gov (United States)

    1972-01-01

    The document covers interconnecting wire harnesses defined in the design standard, including type 6, enclosed in TFE heat shrink tubing; and type 7, flexible armored. Knowledge gained through experience on the Saturn 5 program coupled with recent advances in techniques, materials, and processes was incorporated into this document.

  3. Manufacture and quality control of interconnecting wire harnesses

    Science.gov (United States)

    1973-01-01

    Four-volume series of documents has been prepared as standard reference. Each volume may be used separately and covers wire and cable preparation as well as harness fabrication and installation. Series should be useful addition to libraries of manufactures of electrical and electronic equipment.

  4. Urter har mange funktioner i græsmarken

    DEFF Research Database (Denmark)

    Søegaard, Karen

    2009-01-01

    Urter etableres i græsmarken ud fra mange forskellige formål. De kan udgøre en betydende del af afgrøden, når frømængden er stor nok. Urter-arterne har meget forskellig konkurrenceevne og afgrødekvalitet. Udgivelsesdato: 14-08-09...

  5. Harnessing the potentials of youth for rural household food security ...

    African Journals Online (AJOL)

    The food security question calls for participatory approach by the major stakeholders in the rural household in agriculture Youth are veritable assets in the household because of their dynamism, adventure, ambition and innovativeness. These potentials could be harnessed for rural household food security. This paper ...

  6. 42 CFR 84.1138 - Head harnesses; minimum requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Head harnesses; minimum requirements. 84.1138 Section 84.1138 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume...

  7. Vi har beskæftigelseskrise, ikke uddannelseskrise

    DEFF Research Database (Denmark)

    Grindsted, Thomas Skou; Skou Grindsted, Louise

    2014-01-01

    Universiteterne er for dårlige, og kandidaternes kompetencer er forkerte, derfor ender mange i arbejdsløshed, mener Danmarks Akkrediteringsinstitution, Produktivitetskommissionen og DI. Men for få år siden var der mangel på højtuddannet arbejdskraft, så måske har vi et beskæftigelsesproblem snarere...

  8. Taso Mähar : avatud vannitoaga vanalinna korter / Gitte Hint

    Index Scriptorium Estoniae

    Hint, Gitte

    2003-01-01

    Modernne korter (220 m2). Sisearhitekt Taso Mähar, tema kommentaarid. Kogu korteri ulatuses on sisekujundusmaterjalidena kasutatud väärispuitu, metalli, marmorit ja klaasi. T. Mähari projekteeritud on trepp ja piirded, kamin, baarilett ja õhukesed alumiiniumraamidel mattklaasidega uksed. Ill.: I ja II korruse plaan, 8 värv. vaadet

  9. Har jeg forstået det rigtigt?

    DEFF Research Database (Denmark)

    Horsted, Mette Wenzel; Herly, Lene

    2009-01-01

    Interviews med sygeplejestuderende, der har problemer i forhold til biokemi, anatomi og fysiologi, gav indsigt i disse studerendes læringsstrategier i undervisningen. Ved bevidst at inddrage motiverende faktorer som inklusion, attitude, mening og kompetence (1), kan der skabes et læringsmiljø, hvor...

  10. Harness: Development of a multifunctional protective ship bulkhead

    NARCIS (Netherlands)

    Wal, R. van der; Meuers, R.J.C.

    2016-01-01

    HARNESS is a joint project between governments, industry and TNO with the objective to develop a multifunctional protective bulkhead for application on naval vessels. The multifunctional bulkhead aims at increasing the resilience of naval vessels, reduce damage and repair time and provide a safer

  11. Harnessing the potential of Knowledge Based Engineering in manufacturing design

    NARCIS (Netherlands)

    Van den Berg, T.

    2013-01-01

    An increase in productivity is required for the European aviation industry to remain competitive in a world with rising competition, shorter development timescales, more complex products and decreasing numbers of technically skilled personnel. Fokker Elmo, a Dutch aircraft electrical wiring harness

  12. Using Discussion Methods to Inspire Diversity: Harnessing Social & Cultural Capital

    Science.gov (United States)

    Raison, Brian; Gordon, Beverly

    2012-01-01

    How can you better harness the powerful social capital that exists within diverse individuals, families, businesses, and schools to make positive impacts in your community? What could you add to your next meeting--a Chamber strategic planning session, an employee wellness program, a non-profit board development--to better connect participants with…

  13. Harnessing the power of civil registration and vital statistics systems ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2018-02-27

    Harnessing the power of civil registration and vital statistics systems. A doctor speaks to a woman with her baby in Afghanistan. Graham Crouch/World Bank. Event date: February 27, 2018 to February 28, 2018. Location: IDRC. 150 Kent Street, 8th floor. Ottawa, ON. Canada. Time: 9:00am - 5:45pm. This conference will ...

  14. Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity.

    Science.gov (United States)

    Maury, Mylène M; Tsai, Yu-Huan; Charlier, Caroline; Touchon, Marie; Chenal-Francisque, Viviane; Leclercq, Alexandre; Criscuolo, Alexis; Gaultier, Charlotte; Roussel, Sophie; Brisabois, Anne; Disson, Olivier; Rocha, Eduardo P C; Brisse, Sylvain; Lecuit, Marc

    2016-03-01

    Microbial pathogenesis studies are typically performed with reference strains, thereby overlooking within-species heterogeneity in microbial virulence. Here we integrated human epidemiological and clinical data with bacterial population genomics to harness the biodiversity of the model foodborne pathogen Listeria monocytogenes and decipher the basis of its neural and placental tropisms. Taking advantage of the clonal structure of this bacterial species, we identify clones epidemiologically associated either with food or with human central nervous system (CNS) or maternal-neonatal (MN) listeriosis. The latter clones are also most prevalent in patients without immunosuppressive comorbidities. Strikingly, CNS- and MN-associated clones are hypervirulent in a humanized mouse model of listeriosis. By integrating epidemiological data and comparative genomics, we have uncovered multiple new putative virulence factors and demonstrate experimentally the contribution of the first gene cluster mediating L. monocytogenes neural and placental tropisms. This study illustrates the exceptional power in harnessing microbial biodiversity to identify clinically relevant microbial virulence attributes.

  15. "Har andre plejebørn det som mig?"

    DEFF Research Database (Denmark)

    Warming, H.

    Bogen handler om livet som plejebarn, som det opleves af børnene selv. Den formidler resultaterne fra forskningsprojektet: "Projekt Børnetinget - et talerør for plejebørn", hvor 15 børn i familiepleje er blevet interviewet og hvor 107 nuværende og tidligere plejebørn har skrevet på hjemmesiden ww...

  16. Hammersley’s harness process: Invariant distributions and height fluctuations

    OpenAIRE

    Seppäläinen, Timo; Zhai, Yun

    2017-01-01

    We study the invariant distributions of Hammersley’s serial harness process in all dimensions and height fluctuations in one dimension. Subject to mild moment assumptions there is essentially one unique invariant distribution, and all other invariant distributions are obtained by adding harmonic functions of the averaging kernel. We identify one Gaussian case where the invariant distribution is i.i.d. Height fluctuations in one dimension obey the stochastic heat equation with additive noise (...

  17. Hello World: Harnessing social media for the Rosetta mission

    Science.gov (United States)

    Baldwin, E.; Mignone, C.; O'Flaherty, K. S.; Homfeld, A.-M.; Bauer, M.; McCaughrean, M. J.

    2015-10-01

    The European Space Agency's (ESA) comet-chasing Rosetta mission was launched in 2004, before social media became a popular tool for mainstream communication. By harnessing a range of platforms for communicating the key messages of this unprecedented space adventure as the spacecraft reached its destination ten years later, a wide range of new audiences were reached and could follow this once-in-a-lifetime mission.

  18. Quick-disconnect harness system for helmet-mounted displays

    Science.gov (United States)

    Bapu, P. T.; Aulds, M. J.; Fuchs, Steven P.; McCormick, David M.

    1992-10-01

    We have designed a pilot's harness-mounted, high voltage quick-disconnect connectors with 62 pins, to transmit voltages up to 13.5 kV and video signals with 70 MHz bandwidth, for a binocular helmet-mounted display system. It connects and disconnects with power off, and disconnects 'hot' without pilot intervention and without producing external sparks or exposing hot embers to the explosive cockpit environment. We have implemented a procedure in which the high voltage pins disconnect inside a hermetically-sealed unit before the physical separation of the connector. The 'hot' separation triggers a crowbar circuit in the high voltage power supplies for additional protection. Conductor locations and shields are designed to reduce capacitance in the circuit and avoid crosstalk among adjacent circuits. The quick- disconnect connector and wiring harness are human-engineered to ensure pilot safety and mobility. The connector backshell is equipped with two hybrid video amplifiers to improve the clarity of the video signals. Shielded wires and coaxial cables are molded as a multi-layered ribbon for maximum flexibility between the pilot's harness and helmet. Stiff cabling is provided between the quick-disconnect connector and the aircraft console to control behavior during seat ejection. The components of the system have been successfully tested for safety, performance, ergonomic considerations, and reliability.

  19. Network harness: bundles of routes in public transport networks

    Science.gov (United States)

    Berche, B.; von Ferber, C.; Holovatch, T.

    2009-12-01

    Public transport routes sharing the same grid of streets and tracks are often found to proceed in parallel along shorter or longer sequences of stations. Similar phenomena are observed in other networks built with space consuming links such as cables, vessels, pipes, neurons, etc. In the case of public transport networks (PTNs) this behavior may be easily worked out on the basis of sequences of stations serviced by each route. To quantify this behavior we use the recently introduced notion of network harness. It is described by the harness distribution P(r, s): the number of sequences of s consecutive stations that are serviced by r parallel routes. For certain PTNs that we have analyzed we observe that the harness distribution may be described by power laws. These power laws indicate a certain level of organization and planning which may be driven by the need to minimize the costs of infrastructure and secondly by the fact that points of interest tend to be clustered in certain locations of a city. This effect may be seen as a result of the strong interdependence of the evolutions of both the city and its PTN. To further investigate the significance of the empirical results we have studied one- and two-dimensional models of randomly placed routes modeled by different types of walks. While in one dimension an analytic treatment was successful, the two dimensional case was studied by simulations showing that the empirical results for real PTNs deviate significantly from those expected for randomly placed routes.

  20. A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases.

    Directory of Open Access Journals (Sweden)

    Ashley L Waldron

    Full Text Available Histidyl tRNA Synthetase (HARS is a member of the aminoacyl tRNA synthetase (ARS family of enzymes. This family of 20 enzymes is responsible for attaching specific amino acids to their cognate tRNA molecules, a critical step in protein synthesis. However, recent work highlighting a growing number of associations between ARS genes and diverse human diseases raises the possibility of new and unexpected functions in this ancient enzyme family. For example, mutations in HARS have been linked to two different neurological disorders, Usher Syndrome Type IIIB and Charcot Marie Tooth peripheral neuropathy. These connections raise the possibility of previously undiscovered roles for HARS in metazoan development, with alterations in these functions leading to complex diseases. In an attempt to establish Danio rerio as a model for studying HARS functions in human disease, we characterized the Danio rerio hars gene and compared it to that of human HARS. Using a combination of bioinformatics, molecular biology, and cellular approaches, we found that while the human genome encodes separate genes for cytoplasmic and mitochondrial HARS protein, the Danio rerio genome encodes a single hars gene which undergoes alternative splicing to produce the respective cytoplasmic and mitochondrial versions of Hars. Nevertheless, while the HARS genes of humans and Danio differ significantly at the genomic level, we found that they are still highly conserved at the amino acid level, underscoring the potential utility of Danio rerio as a model organism for investigating HARS function and its link to human diseases in vivo.

  1. Flight performance, energetics and water turnover of tippler pigeons with a harness and dorsal load

    Science.gov (United States)

    Gessaman, J.A.; Workman, G.W.; Fuller, M.R.

    1991-01-01

    We measured carbon dioxide production and water efflux of 12 tippler pigeons (Columba spp.) during seven experimental flights using the doubly labeled water (DLW) method. Prior to the experiment birds were randomly assigned to one of two groups. One group flew as controls (no load or harness) on all seven flights. The other group wore a harness on two flights, a dorsal load/harness package (weighing about 5% of a bird's mass) on two flights, and they were without a load in three flights. Flight duration of pigeons with only a harness and with a dorsal load/harness package was 21 and 26% less, respectively, than the controls. Pigeons wearing a harness, or wearing a dorsal load/harness package lost water 50-90%, and 57-100% faster, respectively, than control pigeons. The mean CO2 production of pigeons wearing a harness or a load/harness package was not significantly different than pigeons without a harness or load. The small sample sizes and large variability in DLW measuremets precluded a good test of the energetic cost of flying with a harness and dorsal load.

  2. Flight performance energetics and water turnovers of Tippler Pigeons with a harness and doorsal load

    Science.gov (United States)

    Gessaman, James A.; Workman, Gar W.; Fuller, Mark R.

    1991-01-01

    We measured carbon dioxide production and water efflux of 12 tippler pigeons (Columba spp.) during seven experimental flights using the doubly labeled water (DLW) method. Prior to the experiment birds were randomly assigned to one of two groups. One group flew as controls (no load or harness) on all seven flights. The other group wore a harness on two flights, a dorsal load/harness package (weighing about 5% of a birda??s mass) on two flights, and they were without a load in three flights. Plight duration of pigeons with only a harness and with a dorsal load/harness package was 21 and 26% less, respectively, than the controls. Pigeons wearing a harness, or wearing a dorsal load/harness package lost water 50-90%, and 57-100% faster, respectively, than control pigeons. The mean CO, production of pigeons wearing a harness or a load/harness package was not significantly different than pigeons without a harness or load. The small sample sizes and large variability in DLW measurements precluded a good test of the energetic cost of flying with a harness and dorsal load.

  3. How can developing countries harness biotechnology to improve health?

    Science.gov (United States)

    Daar, Abdallah S; Berndtson, Kathryn; Persad, Deepa L; Singer, Peter A

    2007-12-03

    The benefits of genomics and biotechnology are concentrated primarily in the industrialized world, while their potential to combat neglected diseases in the developing world has been largely untapped. Without building developing world biotechnology capacity to address local health needs, this disparity will only intensify. To assess the potential of genomics to address health needs in the developing world, the McLaughlin-Rotman Centre for Global Health, along with local partners, organized five courses on Genomics and Public Health Policy in the developing world. The overall objective of the courses was to collectively explore how to best harness genomics to improve health in each region. This article presents and analyzes the recommendations from all five courses. In this paper we analyze recommendations from 232 developing world experts from 58 countries who sought to answer how best to harness biotechnology to improve health in their regions. We divide their recommendations into four categories: science; finance; ethics, society and culture; and politics. The Courses' recommendations can be summarized across the four categories listed above: SCIENCE: - Collaborate through national, regional, and international networks- Survey and build capacity based on proven models through education, training, and needs assessments FINANCE: - Develop regulatory and intellectual property frameworks for commercialization of biotechnology- Enhance funding and affordability of biotechnology- Improve the academic-industry interface and the role of small and medium enterprise ETHICS, SOCIETY, CULTURE: - Develop public engagement strategies to inform and educate the public about developments in genomics and biotechnology- Develop capacity to address ethical, social and cultural issues- Improve accessibility and equity POLITICS: - Strengthen understanding, leadership and support at the political level for biotechnology- Develop policies outlining national biotechnology strategy

  4. How can developing countries harness biotechnology to improve health?

    Directory of Open Access Journals (Sweden)

    Persad Deepa L

    2007-12-01

    Full Text Available Abstract Background The benefits of genomics and biotechnology are concentrated primarily in the industrialized world, while their potential to combat neglected diseases in the developing world has been largely untapped. Without building developing world biotechnology capacity to address local health needs, this disparity will only intensify. To assess the potential of genomics to address health needs in the developing world, the McLaughlin-Rotman Centre for Global Health, along with local partners, organized five courses on Genomics and Public Health Policy in the developing world. The overall objective of the courses was to collectively explore how to best harness genomics to improve health in each region. This article presents and analyzes the recommendations from all five courses. Discussion In this paper we analyze recommendations from 232 developing world experts from 58 countries who sought to answer how best to harness biotechnology to improve health in their regions. We divide their recommendations into four categories: science; finance; ethics, society and culture; and politics. Summary The Courses' recommendations can be summarized across the four categories listed above: Science - Collaborate through national, regional, and international networks - Survey and build capacity based on proven models through education, training, and needs assessments Finance - Develop regulatory and intellectual property frameworks for commercialization of biotechnology - Enhance funding and affordability of biotechnology - Improve the academic-industry interface and the role of small and medium enterprise Ethics, Society, Culture - Develop public engagement strategies to inform and educate the public about developments in genomics and biotechnology - Develop capacity to address ethical, social and cultural issues - Improve accessibility and equity Politics - Strengthen understanding, leadership and support at the political level for biotechnology

  5. On-Orbit Evaluation of a New Treadmill Harness for Improved Crewmember Comfort and Load Distribution

    Science.gov (United States)

    Perusek, G. P.; Sheehan, C. C.; Savina, M. C.; Owings, T. M.; Davis, B. L.; Ryder, J. W.

    2011-01-01

    The current design of the International Space Station (ISS) Treadmill Harness has been reported to cause pain and discomfort to crewmembers during exercise. The Harness Station Development Test Objective (SDTO) provided participating crewmembers (n = 6) with a new harness design, the "Glenn Harness," to evaluate for comfort and loading as compared to the current Treadmill Harness. A novel suite of load-sensing instrumentation was developed to noninvasively measure load distribution and provided a first-ever quantification of actual dynamic loads during treadmill exercise. In addition, crew debriefs provided feedback on harness preference and overall impressions. Conclusions: Post-flight analysis in returned Glenn Harnesses (n = 3) showed minimal wear and tear. Four of the six subjects found the Glenn Harness to be more comfortable in this on-orbit, side-by-side comparison as measured by the crew comfort questionnaire and crew debriefs. Specific areas for improvement have been identified, and forward recommendations will be provided to the Human Research Program. The protocol developed for the SDTO provided valuable insight into crew comfort issues, design improvements, and loading preferences for exercise harnessing, which lays the groundwork for better harnessing systems and training protocols.

  6. When sparks fly harnessing the power of group creativity

    CERN Document Server

    Leonard, Dorothy

    2005-01-01

    Creativity and innovation are evergreen topics. Particularly in today's tough marketplace, companies in every industry are looking for ways to harness creativity and innovation to spur growth and enhance competitiveness. This book differs from many books on creativity in that its focus is on how to manage a group, rather than individual creativity. It refutes much conventional wisdom about where creativity comes from, particularly that creativity does not stem from the random genius of individuals. The authors reveal specific group configurations and strategies that can unleash the collective creativity of any team or group.

  7. "Hello, World!" Harnessing Social Media for the Rosetta Mission

    Science.gov (United States)

    Baldwin, E.; Mignone, C.; Scuka, D.; Homfeld, A. M.; Ranero, K.; Rolfe, E.; Bennett, M.; Schepers, A.; O'Flaherty, K. S.; Bauer, M.; McCaughrean, M.

    2016-03-01

    The European Space Agency's comet-chasing Rosetta mission was launched in 2004, before social media became a popular tool for mainstream communication. As it reached its destination ten years later, new audiences were reached and inspired by this once-in-a-lifetime event by harnessing a range of outlets for communicating the key messages. These included traditional online platforms, such as news websites, blogs, and Livestream, as well as Twitter, Facebook, Instagram, Flickr, YouTube, Google+ and SoundCloud. In this article, we outline the role social media channels played in making Rosetta one of the European Space Agency's biggest communication and public engagement successes.

  8. Harnessing natural product assembly lines: structure, promiscuity, and engineering.

    Science.gov (United States)

    Ladner, Christopher C; Williams, Gavin J

    2016-03-01

    Many therapeutically relevant natural products are biosynthesized by the action of giant mega-enzyme assembly lines. By leveraging the specificity, promiscuity, and modularity of assembly lines, a variety of strategies has been developed that enables the biosynthesis of modified natural products. This review briefly summarizes recent structural advances related to natural product assembly lines, discusses chemical approaches to probing assembly line structures in the absence of traditional biophysical data, and surveys efforts that harness the inherent or engineered promiscuity of assembly lines for the synthesis of non-natural polyketides and non-ribosomal peptide analogues.

  9. Geometry of the inverted Cretaceous Chañarcillo Basin based on 2-D gravity and field data - an approach to the structure of the western Central Andes of northern Chile

    Science.gov (United States)

    Martínez, F.; Maksymowicz, A.; Ochoa, H.; Díaz, D.

    2015-12-01

    This paper discusses an integrated approach that provides new ideas about the structural geometry of the NNE-striking, Cretaceous Chañarcillo Basin located along the eastern Coastal Cordillera in the western Central Andes of northern Chile (27-28° S). The results obtained from the integration of two transverse (E-W) gravity profiles with previous geological information show that the architecture of this basin is defined by a large NNE-SSE-trending and east-vergent anticline ("Tierra Amarilla Anticlinorium"), which is related to the positive reactivation of a former Cretaceous normal fault (Elisa de Bordos Master Fault). Moreover, intercalations of high and low gravity anomalies and steep gravity gradients reveal a set of buried, west-tilted half-grabens associated with a synthetic normal fault pattern. These results, together with the uplift and folding style of the Cretaceous synextensional deposits recognized within the basin, suggest that its structure could be explained by an inverted fault system linked to the shortening of pre-existing Cretaceous normal fault systems. Ages of the synorogenic deposits exposed unconformably over the frontal limb of the Tierra Amarilla Anticlinorium confirm a Late Cretaceous age for the Andean deformation and tectonic inversion of the basin.

  10. Synthesis of Fluorescent Carbon Dots by Gastrointestinal Fluid Treatment of Mongolia Har Gabur

    Directory of Open Access Journals (Sweden)

    Tegexibaiyin Wang

    2017-01-01

    Full Text Available Har Gabur is the carbide obtained from pig manure by burning. The fluorescent carbon dots (CDs of Har Gabur were successfully synthesized through simulating the digestion process of human gastrointestinal tract. Transmission Electron Microscope (TEM analysis showed that the average size of the prepared Har Gabur CDs was 4 nm, with good solubility in water and strong fluorescence under UV irradiation. The X-ray and Raman results showed that the Har Gabur CDs were mainly composed of oxygen “O” and carbon “C” elements, in the forms of “C=O” and “C-O.” The bond energy results showed that the nitrogen “N” atom presented as “C-N” form, which indicated that Har Gabur CDs also contain “N.” In photobleaching assay, Har Gabur CDs showed excellent light stability compared with ordinary organic dye, fluorescein, and Rhodamine B. The fluorescence intensity of Har Gabur CDs was fairly stable within a wide pH range of 3–10. When L-lysine and L-cysteine were applied for the passivation stage, the relative quantum yields were improved by 1.53 and 3.68 times, respectively. Finally, the fluorescence properties of Har Gabur CDs were tested in cells and zebrafish, illustrating that Har Gabur CD has potential in the application of biological labeling and imaging.

  11. Harnessing plant-microbe interactions for enhancing farm productivity.

    Science.gov (United States)

    Macdonald, Catriona; Singh, Brajesh

    2014-01-01

    Declining soil fertility and farm productivity is a major global concern in order to achieve food security for a burgeoning world population. It is reported that improving soil health alone can increase productivity by 10-15% and in combination with efficient plant traits, farm productivity can be increased up to 50-60%. In this article we explore the emerging microbial and bioengineering technologies, which can be employed to achieve the transformational increase in farm productivity and can simultaneously enhance environmental outcomes i.e., low green house gas (GHG) emissions. We argue that metagenomics, meta-transcriptomics and metabolomics have potential to provide fundamental knowledge on plant-microbes interactions necessary for new innovations to increase farm productivity. Further, these approaches provide tools to identify and select novel microbial/gene resources which can be harnessed in transgenic and designer plant technologies for enhanced resource use efficiencies.

  12. Bispecific antibodies and CARs: generalized immunotherapeutics harnessing T cell redirection.

    Science.gov (United States)

    Zhukovsky, Eugene A; Morse, Richard J; Maus, Marcela V

    2016-06-01

    To realize the full potential of cancer immunotherapy, the latest generation immunotherapeutics are designed to harness the potent tumor-killing capacity of T cells. Thus, to mobilize T cells, new optimized bispecific antibody (BsAb) designs, enabling efficient polyclonal redirection of cytotoxic activity through binding to CD3 and a Tumor Associated Antigen (TAA) and refined genetically modified T cells have recently expanded the arsenal of available options for cancer treatment. This review presents the current understanding of the parameters crucial to the design of optimal T cell redirecting BsAb and chimeric antigen receptor (CAR)-modified T cells. However, there are additional questions that require thorough elucidation. Both modalities will benefit from design changes that may increase the therapeutic window. One such approach could employ the discrimination afforded by multiple TAA to significantly increase selectivity. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Spil har potentiale som motivation for læring

    DEFF Research Database (Denmark)

    Hedegaard, Lars Norup

    2016-01-01

    En designbaseret empirisk undersøgelse af almindeligt anvendte gamification elementer. Gamification har til formål at skabe fornøjelse, samt en følelse af leg, i ikke-spil miljøer. Grundet en øget brug af gamification på arbejdspladser og i læreprocesser ses området vigtigt at undersøge yderligere....... Projektet søger at belyse, hvordan gamification påvirker motivationen for læring, herunder hvordan almindeligt anvendte spil-elementer og -genrer kan indgå i planlægningen af læringsaktiviteter. Projektet tager omdrejningspunkt i de studerendes oplevede erfaringer, med den antagelse, at intervention i...

  14. Pattern of injury after rock-climbing falls is not determined by harness type.

    Science.gov (United States)

    Hohlrieder, Matthias; Lutz, Martin; Schubert, Heinrich; Eschertzhuber, Stephan; Mair, Peter

    2007-01-01

    Experimental data indicate that when using a sit harness alone, any major fall during rock climbing may cause life-threatening thoraco-lumbar hyperextension trauma or "head down position" during suspension. To clarify the actual influence of the type of harness on the pattern and severity of injury, accidents involving a major fall in a climbing harness were analyzed retrospectively. Individuals with a height of fall equal to or exceeding 5 m were identified through a search of accident and emergency records for the period from 2000 to 2004. Data concerning the circumstances of the fall and the patterns of injury were obtained from personal interviews, flight and accident reports, as well as hospital medical records. Of a total of 113 climbers identified, 73 (64.6%) used a sit harness alone, whereas 40 (35.4%) used a body harness. Fractures and dislocations of the extremities, the shoulder, and the pelvic region were the most common injuries, while the most severe injuries occurred in the head and neck region. Although most falls were associated with mild or moderate injuries, 13 (11.5%) climbers sustained severe or critical multisystem trauma. Falls on more difficult routes were associated with less severe injury. The type of harness used did not influence the pattern or severity of injury. In particular, no evidence was found for the existence of a thoraco-lumbar hyperextension trauma. The type of harness does not influence the pattern or severity of injury, and the forces transferred via the harness do not cause a specific harness-induced pathology. We did not find any evidence that hyperextension trauma of the thoraco-lumbar region is an important mechanism of injury in climbers using a sit harness alone. Rock contact during the fall, and not the force transferred through the harness, is the major cause of significant injury in climbing accidents.

  15. Hvor mange alkoholikere har vi? Alkoholproblemer i Oslos befolkning

    Directory of Open Access Journals (Sweden)

    Hans Olav Fekjær

    2009-10-01

    Full Text Available  SAMMENDRAGI de siste tiårene har bekymringen for alkoholproblemer vært knyttet til begreper som "alkoholiker" eller "de somhar alkoholproblemer". Begrepene impliserer at de fleste problemene er langvarige tilstander hos en avgrenset,behandlingstrengende gruppe. Den foreliggende undersøkelsen var lagt opp som en post-enquete. Skjemaene blesendt til et representativt utvalg Oslo-borgere i alderen 18-59 år. En mottok 2051 skjemaer og oppnådde en svarprosentpå 77. Respondentene ble spurt om de hadde opplevet 8 typer skadevirkninger knyttet til sin alkoholbruk.Avhengig av antall skadevirkninger ble personens alkoholproblemer definert som moderate, betydelige eller store.Hvis "alkoholisme" defineres som å ha opplevet et visst antall av de 8 problemene, varierer antall "alkoholikere"dramatisk avhengig av antall skadevirkninger som kreves: Hvis det kreves 7 problemer, er færre enn 1% av dennebefolkningen alkoholikere. Hvis det kreves 3 problemer er 21% alkoholikere. Hyppigheten av alkoholproblemerreduseres gradvis med økende alder, fra 29% mellom 18 og 25 års alder til 8% mellom 45 og 60 år. De aller flestealkoholproblemer er ikke knyttet til daglig drikking eller til et svært høyt forbruk pr. år. De fleste som noen ganghar opplevet betydelige eller store problemer synes å "modne ut" av problemdrikking uten å stoppe å drikke oguten noen form for behandling. De fleste som har betydelige eller store problemer har ikke ønsket å kutte sinalkoholbruk ut eller sterkt ned. Blant dem som har ønsket det, har over 90% klart det helt eller delvis. Undersøkelsenbekrefter tidligere befolkningsstudier som indikerer at de fleste alkoholproblemer er spredt blant en storandel av den yngre mannlige befolkningen som stort sett synes å ha kontroll over sin alkoholbruk, ikke kan kallesavhengige og ikke kommer til alkoholistbehandling. Artikkelen drøfter hvilke konsekvenser dette har forsamfunnets strev for å redusere problemene.Fekjær HO

  16. 14 CFR 29.785 - Seats, berths, litters, safety belts, and harnesses.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Seats, berths, litters, safety belts, and harnesses. 29.785 Section 29.785 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... and Cargo Accommodations § 29.785 Seats, berths, litters, safety belts, and harnesses. (a) Each seat...

  17. 14 CFR 121.311 - Seats, safety belts, and shoulder harnesses.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Seats, safety belts, and shoulder harnesses. 121.311 Section 121.311 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... § 121.311 Seats, safety belts, and shoulder harnesses. (a) No person may operate an airplane unless...

  18. 14 CFR 137.42 - Fastening of safety belts and shoulder harnesses.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Fastening of safety belts and shoulder harnesses. 137.42 Section 137.42 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... AGRICULTURAL AIRCRAFT OPERATIONS Operating Rules § 137.42 Fastening of safety belts and shoulder harnesses. No...

  19. 14 CFR 25.785 - Seats, berths, safety belts, and harnesses.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Seats, berths, safety belts, and harnesses. 25.785 Section 25.785 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... and Cargo Accommodations § 25.785 Seats, berths, safety belts, and harnesses. (a) A seat (or berth for...

  20. 14 CFR 27.785 - Seats, berths, litters, safety belts, and harnesses.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Seats, berths, litters, safety belts, and harnesses. 27.785 Section 27.785 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Cargo Accommodations § 27.785 Seats, berths, litters, safety belts, and harnesses. (a) Each seat, safety...

  1. 14 CFR 23.785 - Seats, berths, litters, safety belts, and shoulder harnesses.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Seats, berths, litters, safety belts, and shoulder harnesses. 23.785 Section 23.785 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT... belts, and shoulder harnesses. There must be a seat or berth for each occupant that meets the following...

  2. 14 CFR 135.171 - Shoulder harness installation at flight crewmember stations.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Shoulder harness installation at flight crewmember stations. 135.171 Section 135.171 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... ON BOARD SUCH AIRCRAFT Aircraft and Equipment § 135.171 Shoulder harness installation at flight...

  3. 14 CFR 91.107 - Use of safety belts, shoulder harnesses, and child restraint systems.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Use of safety belts, shoulder harnesses, and child restraint systems. 91.107 Section 91.107 Aeronautics and Space FEDERAL AVIATION... OPERATING AND FLIGHT RULES Flight Rules General § 91.107 Use of safety belts, shoulder harnesses, and child...

  4. 14 CFR 105.43 - Use of single-harness, dual-parachute systems.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Use of single-harness, dual-parachute systems. 105.43 Section 105.43 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Packing § 105.43 Use of single-harness, dual-parachute systems. No person may conduct a parachute...

  5. Når sex er en ret, hvem har så pligt?

    DEFF Research Database (Denmark)

    Munk-Madsen, Eva

    2007-01-01

    Socialministeriet har fastslået i en vejledning, at samfundet har omsorgspligt for funktionshæmmedes borgeres  seksuelle udfoldelsesmulighder. Tre grupper er udpeget som dem der skal varetage denne omsorgspligt på samfundets vegne: ansatte hjælpepersoner, seksualvejledere og prostituerede. I modt...

  6. 42 CFR 84.173 - Harnesses; installation and construction; minimum requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum... SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Non-Powered Air-Purifying Particulate Respirators § 84.173 Harnesses; installation and...

  7. 42 CFR 84.133 - Harnesses; installation and construction; minimum requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum... SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Supplied-Air Respirators § 84.133 Harnesses; installation and construction; minimum requirements...

  8. 42 CFR 84.116 - Harnesses; installation and construction; minimum requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum... SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks § 84.116 Harnesses; installation and construction; minimum requirements. (a) Each gas...

  9. 42 CFR 84.196 - Harnesses; installation and construction; minimum requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum... SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Chemical Cartridge Respirators § 84.196 Harnesses; installation and construction; minimum...

  10. 42 CFR 84.73 - Harnesses; installation and construction; minimum requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum... OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Self-Contained Breathing Apparatus § 84.73 Harnesses; installation and construction; minimum requirements. (a...

  11. [Vascular thrombosis and pulmonary thrombo-embolism due to harness suspension].

    Science.gov (United States)

    Pisati, G; Cerri, S; Achille, G; Rossi, G; Lorenzi, G

    2007-01-01

    In many sports (such as rock-climbing and caving) and working activities (e.g., construction and maintenance of buildings, pruning of lung-trunked trees, abseiling in wells) people run the risk of falling from a height. To prevent the effects of any potential fall, personalprotection devices consisting of at least a body holding device (i.e. a harness of some type), a lanyard and a reliable anchor are used. Reporting on the occurrence of vascular thrombosis in subjects undergoing prolonged hanging in a harness, either for work or recreation. We investigated patients treated for vascular thrombosis in our hospital in the last 5 years to identify subjects with frequent use of a harness. We identified a 36-year-old rock-climber who developed pulmonary thrombo-embolism and infarction 5 days after he had been wearing a harness for 12 hours consecutively, and a 32 year-old worker who often used a harness to fix wire-nettings to prevent rocks falling from steep places and suffered thrombosis of the left superficial femoral artery. A feature of both cases was the considerable length of time spent hanging in the harness and the absence of alternative risk factors for thrombosis. Prolonged hanging in a harness can be dangerous in itself because it can produce vascular thrombosis. Reduction of intravascular blood flow (stasis) and compression of the femoral veins by harness groin straps were the likely pathogenetic mechanisms of the described diseases. The importance is stressed of prevention, which must be based on planned regular breaks in the hanging position, checking on the fit and comfort level of the harness before it is first used, as well as medical surveillance of the subjects who spend prolonged periods in a harness for work or recreation.

  12. Harnessing and understanding feedback technology in applied settings.

    Science.gov (United States)

    Phillips, Elissa; Farrow, Damian; Ball, Kevin; Helmer, Richard

    2013-10-01

    Research on the influence of augmented feedback effects on both skill learning and performance has been examined from two differing positions, generally reflective of two core movement science disciplines: motor learning and biomechanics. The motor learning approach has been to examine the content and timing of feedback under tightly controlled laboratory settings, with a focus on simple tasks and the influence of movement outcome feedback. At the other end of the spectrum are biomechanical approaches, which have been primarily devoted to demonstrating the capacity of measurement technology to quantify and report on movement pattern effectiveness. This review highlights the gap left by these two approaches and argues that advancement of our understanding of feedback application in practical settings requires a shift towards a multi-disciplinary focus. A particular focus of the review is on how researchers and practitioners need to harness our understanding and subsequent application of the emergent feedback technologies most prevalent in elite sport settings and clinical sports medicine. We highlight important considerations for future applied multidisciplinary research driven by relevant theory and methodological design to more comprehensively capture how feedback systems can be used to facilitate the development of skilled performance.

  13. Harnessing the Therapeutic Potential of Th17 Cells

    Directory of Open Access Journals (Sweden)

    Jonas Bystrom

    2015-01-01

    Full Text Available Th17 cells provide protective immunity to infections by fungi and extracellular bacteria as well as cancer but are also involved in chronic inflammation. The cells were first identified by their ability to produce interleukin 17A (IL-17A and, subsequently, associated with chronic inflammation and autoimmunity. Th17 cells have some gene profile similarity with stem cells and can remain dormant in mucosal tissues for long periods. Indeed, recent studies suggest that functionally distinct subsets of pro- and anti-inflammatory Th17 cells can interchange phenotype and functions. For development, Th17 cells require activation of the transcription factors STAT3 and RORγt while RUNX1, c-Maf, and Aiolos are involved in changes of phenotype/functions. Attempts to harness Th17 cells against pathogens and cancer using vaccination strategies are being explored. The cells gain protective abilities when induced to produce interferon γ (IFNγ. In addition, treatment with antibodies to IL-17 is effective in treating patients with psoriasis, psoriatic arthritis, and refectory rheumatoid arthritis. Moreover, since RORγt is a nuclear receptor, it is likely to be a potential future drug target for modulating Th17 functions. This review explores pathways through which Th17 subsets are induced, the molecular basis of their plasticity, and potential therapeutic strategies for their modulation in diseases.

  14. Biology-oriented synthesis: harnessing the power of evolution.

    Science.gov (United States)

    van Hattum, Hilde; Waldmann, Herbert

    2014-08-27

    For scientists to gain a better understanding of nature, biological research is greatly aided by small-molecule modulators that perturb protein activity without fundamentally altering the underlying biological systems. The number of possible interfering molecules, however, is so vast that, due to limitations in existing matter and time required for synthesis, they cannot be covered comprehensively. Because proteins and their cognate natural product ligands and substrates co-evolved, these naturally occurring ligands can serve as structural starting points to explore the biologically relevant chemical space. To this end, known natural products are structurally classified on the basis of their core scaffolds and hierarchically arranged in the "natural product tree", which can be annotated for bioactivity and intuitively navigated with currently available software. Biologically relevant scaffolds inspire the synthesis of compound libraries enriched in biological activity. This Perspective describes the development of "biology-oriented synthesis" as a guiding principle to harness the power of evolution in the quest for novel bioactive small molecules for chemical biology research and drug discovery.

  15. Mic Flocks in the Cloud: Harnessing Mobile Ubiquitous Sensor Networks

    Science.gov (United States)

    Garces, M. A.; Christe, A.

    2015-12-01

    Smartphones provide a commercial, off-the-shelf solution to capture, store, analyze, and distribute infrasound using on-board or external microphones (mics) as well as on-board barometers. Free iOS infrasound apps can be readily downloaded from the Apple App Store, and Android versions are in progress. Infrasound propagates for great distances, has low sample rates, and provides a tractable pilot study scenario for open distributed sensor networks at regional and global scales using one of the most ubiquitous sensors on Earth - microphones. Data collection is no longer limited to selected vendors at exclusive prices: anybody on Earth can record and stream infrasound, and the diversity of recording systems and environments is rapidly expanding. Global deployment may be fast and easy (www.redvox.io), but comes with the cost of increasing data volume, velocity, variety, and complexity. Flocking - the collective motion of mobile agents - is a natural human response to threats or events of interest. Anticipating, modeling and harnessing flocking sensor topologies will be necessary for adaptive array and network processing. The increasing data quantity and complexity will exceed the processing capacity of human analysts and most research servers. We anticipate practical real-time applications will require the on-demand adaptive scalability and resources of the Cloud. Cloud architectures for such heterogeneous sensor networks will consider eventual integration into the Global Earth Observation System of Systems (GEOSS).

  16. Harnessing the electromagnetic absorptions of metamaterials for positive applications

    Science.gov (United States)

    Xiang, Yuanjiang; Zou, Yanhong; Luo, Hailu; Dai, Xiaoyu; Wen, Shuangchun; Fan, Dianyuan

    2010-08-01

    Absorption or loss is inevitable for the metal-based metamaterials (MMs) due to the intrinsic loss of the metal, and constitutes a major hurdle to the practical realization of most applications such as a sub-wavelength lens. Thus, to reduce the losses becomes one of the major challenges in the MM field. However, the inevitable loss can also be harnessed to take a positive role in the applications of MMs such as stealth technology or other types of cloaking devices. In this presentation, after a brief review of the advances in MMs-based absorbers, we present several schemes to fulfill the desired electromagnetic absorption properties, both linear and nonlinear. For linear absorption, we have experimentally demonstrated that the absorption performance of an ordinary microwave absorbing material can be evidently improved by using the electric resonance resulting from an array of subwavelength metallic circuit elements. For nonlinear absorption, we show theoretically that the active linear magnetic permeability induces a nonlinear absorption, similar to the two-photon absorption (TPA), of electric field in a lossy MM with a Kerr-type nonlinear polarization.

  17. The globalization of health research: harnessing the scientific diaspora.

    Science.gov (United States)

    Anand, Nalini P; Hofman, Karen J; Glass, Roger I

    2009-04-01

    The scientific diaspora is a unique resource for U.S. universities. By drawing on the expertise, experience, and catalytic potential of diaspora scientists, universities can capitalize more fully on their diverse intellectual resources to make lasting contributions to global health. This article examines the unique contributions of the diaspora in international research collaborations, advantages of harnessing the diaspora and benefits to U.S. universities of fostering these collaborations, challenges faced by scientists who want to work with their home countries, examples of scientists engaging with their home countries, and specific strategies U.S. universities and donors can implement to catalyze these collaborations. The contributions of the diaspora to the United States are immense: International students enrolled in academic year 2007-2008 contributed an estimated $15 billion to the U.S. economy. As scientific research becomes increasingly global, the percentage of scientific publications with authors from foreign countries has grown from 8% in 1988 to 20% in 2005. Diaspora scientists can help build trusting relationships with scientists abroad, and international collaborations may improve the health of underserved populations at home. Although opportunities for diaspora networks are increasing, most home countries often lack enabling policies, infrastructure, and resources to effectively utilize their diaspora communities abroad. This article examines how some governments have successfully mobilized their scientific diaspora to become increasingly engaged in their national research agendas. Recommendations include specific strategies, including those that encourage U.S. universities to promote mini-sabbaticals and provide seed funding and flexible time frames.

  18. Gigantic blue shift of the H-Ar stretch vibration in pi hydrogen-bonded C(2)H(2)...HArCCF complex.

    Science.gov (United States)

    Cheng, Jianbo; Wang, Yilei; Li, Qingzhong; Liu, Zhenbo; Li, Wenzuo; Gong, Baoan

    2009-04-30

    Quantum chemical calculations have been performed to study the structure and properties of the pi hydrogen-bonded complex formed between acetylene and HArCCF at the MP2/6-311++G(2d,2p) level. The C(2)H(2)...HCCF and C(2)H(2)...HCCArF complexes were also studied for comparison with the C(2)H(2)...HArCCF complex. The basis set superposition errors (BSSE)-counterpoise corrected potential-energy surface (PES) has a larger influence on the structure and properties of the C(2)H(2)...HArCCF complex than those of the C(2)H(2)...HCCF and C(2)H(2)...HCCArF complexes. The C(2)H(2)...HArCCF complex exhibits a very large harmonic vibrational frequency blue shift of 574 cm(-1) for the H-Ar stretch, whereas the C(2)H(2)...HCCF and C(2)H(2)...HCCArF complexes exhibit a small red shift of 35 and 47 cm(-1) for the H-C stretch, respectively; upon complexation the IR intensity decreases in the former, whereas it increases in the latter. The origin of the frequency shift and nature of the hydrogen bond in these complexes have been unveiled with the natural bond orbital analysis and energy decomposition.

  19. Spelberoendets problematik : En hermeneutisk studie om hur människor som har ett spelberoende upplever sig avvikande i vardagslivet

    OpenAIRE

    Bienkowski, Allan

    2016-01-01

    Detta arbete har tagit upp frågan om hur personer som har ett spelberoende upplever sig i vardagslivet. Syftet med studien var att studera ifall personer som har ett spelberoende upplever sig avvikande i vardagslivet och i sådant fall hur. 

  20. A Silurian-early Devonian slab window in the southern Central Asian Orogenic Belt: Evidence from high-Mg diorites, adakites and granitoids in the western Central Beishan region, NW China

    Science.gov (United States)

    Zheng, Rongguo; Xiao, Wenjiao; Li, Jinyi; Wu, Tairan; Zhang, Wen

    2018-03-01

    The Beishan orogenic belt is a key region for deciphering the accretionary processes of the southern Central Asian Orogenic Belt. Here in this paper we present new zircon U-Pb ages, bulk-rock major and trace element, and zircon Hf isotopic data for the Baitoushan, and Bagelengtai plutons in the western Central Beishan region to address the accretionary processes. The Baitoushan pluton consists of quartz diorites, monzonites and K-feldspar granites, with zircon LA-ICP-MS U-Pb ages of 435 Ma, 421 Ma and 401 Ma, respectively. The Baitoushan quartz diorites and quartz monzonites exhibit relatively high MgO contents and Mg# values (63-72), display enrichments in LILEs and LREEs, and exhibit high Ba (585-1415 ppm), Sr (416-570 ppm) and compatible element (such as Cr and Ni) abundances, which make them akin to typical high-Mg andesites. The Baitoushan quartz diorites and quartz monzonites were probably generated by the interaction of subducted oceanic sediment-derived melts and mantle peridotites. The Baitoushan K-feldspar granites are ascribed to fractionated I-type granites with peraluminous and high-K calc-alkaline characteristics. They exhibit positive εHf(t) values (2.43-7.63) and Mesoproterozoic-Neoproterozoic zircon Hf model ages (0.92-1.60 Ga). Those early Devonian granites, including Baitoushan K-feldspar granite and Gongpoquan leucogranites (402 Ma), are derived from melting of the mafic lower crust and/or sediments by upwelling of hot asthenospheric mantle. The Bagelengtai granodiorites exhibit similar geochemical signatures with that of typical adakites, with a zircon SHRIMP U-Pb age of 435 Ma. They exhibit relatively high Sr (502-628 ppm) and Al2O3 (16.40-17.40 wt.%) contents, and low MgO (1.02-1.29 wt.%), Y (3.37-6.94 ppm) and HREEs contents, with relatively high Sr/Y and (La/Yb)N ratios. The Bagelengtai granodiorites were derived from partial melting of subducted young oceanic crust, with significant contributions of subducted sediments, subsequently

  1. Harnessing optical loss for unique microlaser functionality (Conference Presentation)

    Science.gov (United States)

    Feng, Liang

    2017-05-01

    Lasers, as the key driving force in the field of optics and photonics over other photonic components, are now being significantly benefited from the studies of nanophotonics and metamaterials, broadening laser physics and device applications. The properties of light are much more beyond its simple intensity and temporal characteristics. The fruitful nature of light provides a great variety of freedoms in manipulating light for modern photonic applications, including spin (polarization), chirality, angular momentum, and spin-orbit coupling. Unfortunately, all these fundamental properties and functionalities of light have not been fully exploited in micro/nano-laser systems because the conventional principles of laser design in bulk optics cannot be easily scaled down to the micro/nano scale. The capability of creating microlasers with controlled spin/orbital information and chirality in their radiations is expected to revolutionize next generation of photonic systems for computing and communication. In this talk, I will focus on our recent effort in harnessing optical losses for unique microlaser functionalities, in particular, an orbital angular momentum (OAM) microlaser that structure and twist the lasing radiation at the microscale. The effective generation of OAM lasing, especially at a micro/nano-scale, could address the growing demand for information capacity. By exploiting the emerging non-Hermitian photonics design at an exceptional point, we demonstrate a microring laser producing a single-mode OAM vortex lasing with the ability to precisely define the topological charge of the OAM mode and its polarization state. Our OAM microlaser could find applications in the next generation of integrated optoelectronic devices for optical communications.

  2. Heritability and factors associated with number of harness race starts in the Spanish Trotter horse population.

    Science.gov (United States)

    Solé, M; Valera, M; Gómez, M D; Sölkner, J; Molina, A; Mészáros, G

    2017-05-01

    Longevity/durability is a relevant trait in racehorses. Genetic analysis and knowledge of factors that influence number of harness race starts would be advantageous for both horse welfare and the equine industry. To perform a genetic analysis on harness racing using number of races as a measure of longevity/durability and to identify factors associated with career length in Spanish Trotter Horses (STH). Longitudinal study. Performance data (n = 331,970) on the STH population for harness racing at national level between 1990 and 2014 were used. A grouped data model was fitted to assess factors influencing the risk of ending harness racing career and to estimate the heritability and breeding values for total number of harness races starts as an indicator of horses' longevity and durability. The model included sex, age at first race and first start earnings as time-independent effects, and the calendar year, driver, trainer, racetrack category and season of competition as time-dependent effects. Across the whole dataset, the average number of harness races horses achieved in Spain was 54.7 races, and this was associated with the horses' sex, age at first race and first start earnings, calendar year, driver, racetrack category, and season. The heritability estimated (0.17 ± 0.01) for number of harness race starts indicates that a beneficial response to direct genetic selection can be expected. Data on horses' health status were not available. Horses' total number of harness race starts is a promising tool for genetic analysis and the evaluation of racing longevity and durability. The estimated heritability provides evidence to support the application of genetic selection of total career number of races to improve longevity/durability of STH. © 2016 EVJ Ltd.

  3. Electrical failure on satellite's power harnesses due to small debris impacts

    OpenAIRE

    Hirai, Takayuki; Higashide, Masumi; Kurosaki, Hirohisa; Kawakita, Shirou; Mando, Yuki; Yamaguchi, Shota; Tanaka, Koji; 平井, 隆之; 東出, 真澄; 黒崎, 裕久; 川北, 史朗; 万戸, 雄輝; 山口, 翔太; 田中, 孝治

    2017-01-01

    Loss of satellite functions due to space debris collisions includes not only mechanical failures like breakup of satellite main bodies but also electric failures such as decrease in power supply from solar arrays and power harnesses. In particular, the past hypervelocity impact experiments suggest that sustained arcs and resulting ground faults on the power harnesses could be triggered by impacts of tiny space debris particles smaller than 1 mm which constantly impact on satellite surfaces. T...

  4. Hello, world: Harnessing social media for the Rosetta mission

    Science.gov (United States)

    Baldwin, Emily; Mignone, Claudia; O'Flaherty, Karen; Homfeld, Anne-Mareike; Bauer, Markus; McCaughrean, Mark

    2015-04-01

    The European Space Agency's (ESA) comet-chasing Rosetta mission was launched in 2004, before social media became a popular tool for mainstream communication. By harnessing a range of platforms for communicating the key messages of this unprecedented mission as it reached its destination ten years later, new audiences were reached and a global impact was achieved. Rosetta-specific social media accounts - @ESA_Rosetta on Twitter, the Rosetta Mission Facebook page and the rosettamission Instagram account - were developed during 2013/14 and used alongside the traditional reporting line of the main ESA website and the Rosetta blog to build awareness about the mission. Coordinated with ESA's existing social media channels (Flickr, YouTube, G+, Twitter, Facebook and Livestream) and with the support of ESA's country desks and Rosetta partner agency accounts (including @philae2014), information could be shared in a number of European languages, ensuring a wide reach across Europe - and the world. We discuss the roles of the various social media accounts in supporting and promoting the competitions and social media campaigns that were built around the key mission milestones of 2014: waking up from deep space hibernation (January), arriving at Comet 67P/Churyumov-Gerasimenko (August) and naming the landing site for Philae ahead of the landing event in November. We discuss the different approach to each channel, such as the first person twitter accounts, the dialogue with and between blog users, and the discussions held live via G+ Hangouts with leading scientists and spacecraft operators. We compare and contrast the audiences, the interaction we had with them and how challenges were overcome. We also use the science-fiction-meets-science-fact Ambition short movie, and its "undercover" dissemination on social media, as an example of how the profile of the Rosetta mission was raised in a unique way. By using a variety of social media platforms to target different audiences with

  5. An examination of shoulder kinematics and kinetics when using a commercial trunk harness while sheep shearing.

    Science.gov (United States)

    Gregory, Diane E; Milosavljevic, Stephan; Pal, Poonam; Callaghan, Jack P

    2008-01-01

    Sheep shearing is a very physically demanding occupation, especially on the low back, such that many commercial harnesses have been developed to help reduce the load on the back. Such harnesses have been shown to significantly reduce peak and cumulative low back loads; however, the effect that these harnesses have on the shoulders, which are also highly involved during sheep shearing, has not been previously examined. The purpose of this study was to examine the shoulder postures and cumulative shoulder moments of 12 New Zealand sheep shearers. The use of the trunk harness reduced the percentage of time spent in shoulder flexion greater than 90 degrees and the time spent in shoulder abduction greater than 45 degrees as well as reduced the cumulative net joint flexor, abductor, and adductor shoulder moments by a minimum of 21%, 14%, and 42%, respectively. Therefore, the use of a commercial trunk harness to reduce low back injury may also help to reduce the risk of shoulder injury while sheep shearing.

  6. National Strategies to Harness Information Technology Seeking Transformation in Singapore, Finland, the Philippines, and South Africa

    CERN Document Server

    Knight, Peter

    2012-01-01

    The ability to harness Information Communication Technologies (ICTs) is increasingly at the heart of competitiveness and sustainable growth. As countries engage in an increasingly competitive global economy, they are trying to weave ICT into their development strategies, in the same way enterprises have learned to use ICT to transform their business models and strategies. This integration offers a new path to development that is responsive to the challenges of our times.  In National Strategies to Harness Information Technology, Nagy Hanna and Peter Knight provide a framework for assessing the opportunities, challenges, and prospects for “e-transformation” and for analyzing the options and innovations adopted to manage the e-transformation process.  They ask hard questions: what does it take to harness ICT to transform an economy?  Why some countries accelerate their development journey with ICT while others fail?  How did successful countries balance the need for strategic leadership with bottom up ...

  7. Genetic suppressors of the Lotus japonicus har1-1 hypernodulation phenotype

    DEFF Research Database (Denmark)

    Murray, Jeremy; Karas, Bogumil; Ross, Loretta

    2006-01-01

    symbiosis (RNS), a screen for suppressors of the L. japonicus har1-1 hypernodulation phenotype was performed. Of 150,000 M2 plants analyzed, 61 stable L. japonicus double-mutant lines were isolated. In the context of the har1-1 mutation, 26 mutant lines were unable to form RNS, whereas the remaining 35...... mutant lines carried more subtle symbiotic phenotypes, either forming white ineffective nodules or showing reduced nodulation capacity. When challenged with Glomus intraradices, 18 of the 61 suppressor lines were unable to establish a symbiosis with this arbuscular mycorrhiza fungus. Using a combined...

  8. Science har fundet løsning på CURIS-registrering

    DEFF Research Database (Denmark)

    Mørch, Frede

    2012-01-01

    Fakultetsbibliotekar Frede Mørch fortæller her om den løsning, som Science har indført for at sikre at alle forskningspublikationer bliver registreret i databasen, CURIS, uden at forskerne skal spilde tid på det.......Fakultetsbibliotekar Frede Mørch fortæller her om den løsning, som Science har indført for at sikre at alle forskningspublikationer bliver registreret i databasen, CURIS, uden at forskerne skal spilde tid på det....

  9. Fem sociale medier har »uindskrænket ret« til at misbruge alt dit indhold

    DEFF Research Database (Denmark)

    Nielsen, Jøren Ullits Olai

    2016-01-01

    Ved du, hvor meget kontrol du har over dit indhold på Facebook, YouTube, Snapchat, Instagram og Twitter? Her giver en juraforsker dig det forkromede overblik.......Ved du, hvor meget kontrol du har over dit indhold på Facebook, YouTube, Snapchat, Instagram og Twitter? Her giver en juraforsker dig det forkromede overblik....

  10. How to Move in a Jostling Crowd The Art of Harnessing Random ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 1; Issue 10. How to Move in a Jostling Crowd The Art of Harnessing Random Motions. G S Ranganath. Research News Volume 1 Issue 10 October 1996 pp 84-86. Fulltext. Click here to view fulltext PDF. Permanent link:

  11. Unge er en flok egoistiske individualister, der har nok i sig selv

    DEFF Research Database (Denmark)

    Kofod, Anne

    2005-01-01

     Nutidens unge har som oftest en tvetydig identitet: På én og samme tid søger de sammen i sociale fællesskaber og gør alt for at skille sig ud som individualister.   Udgivelsesdato: 27. september...

  12. The Facebook-in-Action: Challenging, Harnessing and Enhancing Students Class Assignments and Projects

    Science.gov (United States)

    Saifudin, Adam Mohd; Yacob, Aizan; Saad, Rohaizah

    2016-01-01

    Issues of universities students harnessing and capitalizing the usage of Facebook for their own learning capabilities and effective thinking is always the focus of education scholars, in assessing the quality class assignments and projects produced by them. Therefore, Facebook is now becoming unbearable influence since the internet activation in…

  13. A Comparative Study of Harnessing Cattle - An Important Chapter in the History of European Ethnology

    Czech Academy of Sciences Publication Activity Database

    Woitsch, Jiří

    2017-01-01

    Roč. 38 (2017), s. 59-89 ISSN 1335-4116 R&D Projects: GA ČR GA15-03754S Institutional support: RVO:68378076 Keywords : harnessing cattle * European ethnology * history of ethnology Subject RIV: AC - Archeology, Anthropology, Ethnology

  14. Kvote 2 optagelse og akademiske præstationer: Hvor stor betydning har det adgangsgivende eksamenssnit?

    DEFF Research Database (Denmark)

    O'Neill, Lotte; Vonsild, Marie Cecilie; Wallstedt, Birgitta

    2013-01-01

    Kvote 2 optagelse (optagelsesprøver) til medicinstudiet har vist sig at have virket beskyttende på tidligt studiefrafald sammenlignet med kvote 1optagelse på Syddansk Universitet. Dette prospektive kohorte studie af de samme kohorter viser, at de lavere adgangsgivende karakterer i kvote 2 gruppen...

  15. Kvote 2 optagelse og akademiske præstationer: Hvor stor betydning har det adgangsgivende eksamenssnit?

    DEFF Research Database (Denmark)

    O'Neill, Lotte Dyhrberg; Vonsild, Maria Cecilie; Wallstedt, Birgitta

    2013-01-01

    Dansk abstract Kvote 2 optagelse (optagelsesprøver) til medicinstudiet har vist sig at have virket beskyttende på tidligt studiefrafald sammenlignet med kvote 1optagelse på Syddansk Universitet. Dette prospektive kohorte studie af de samme kohorter viser, at de lavere adgangsgivende karakterer i ...

  16. 42 CFR 84.1133 - Harnesses; installation and construction; minimum requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Harnesses; installation and construction; minimum requirements. 84.1133 Section 84.1133 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE...

  17. Taso Mähar : maali ümber ehitatud maja / Gitte Hint

    Index Scriptorium Estoniae

    Hint, Gitte

    2003-01-01

    220-ruutmeetrise ühekorde eramu sisekujundus. Arhitekt Emil Urbel. Sisearhitekt Taso Mähar, tema kommentaarid. Köögimööbel on T. Mähari projekteeritud. Elutoas mööblifirma T&T Mang pehme mööbel, seinal Lemming Nageli maal "Punane joon all - Burn Out". Ill.: plaan, 17 värv. vaadet

  18. Secondary geochemical reactions in hydrothermal energy harnessing; Geochemische Folgereaktionen bei der hydrogeothermalen Energiegewinnung

    Energy Technology Data Exchange (ETDEWEB)

    Kuehn, M.

    1996-12-01

    This thesis is in six parts: description of geothermal energy harnessing, analytics, geochemical-thermodynamic modellings, experimental investigations, discussion of results, summary. (HW) [Deutsch] Die vorliegende Dissertationsschrift gliedert sich in 6 Teile: - Beschreibung der geothermischen Energienutzung - Analytik - geochemische-thermodynamische Modellierungen - experimentelle Untersuchungen - Diskussion der Ergebnisse - Zusammenfassung. (HW)

  19. Harnessing the power of big data: infusing the scientific method with machine learning to transform ecology

    Science.gov (United States)

    Most efforts to harness the power of big data for ecology and environmental sciences focus on data and metadata sharing, standardization, and accuracy. However, many scientists have not accepted the data deluge as an integral part of their research because the current scientific method is not scalab...

  20. Universities plan revolution in research; Four institutes will harness top brains

    CERN Multimedia

    Buie, E

    2003-01-01

    "Scotland is on the brink of revolutionising its approach to university research by creating four institutions that would harness the country's top brains to work together in specific areas. The move to create pan-academic institutes in physics, life-sciences, economics and creative arts has won the backing of the principals of every higher education institution in Scotland..." (1 page).

  1. Pressure distribution under three different types of harnesses used for guide dogs.

    Science.gov (United States)

    Peham, C; Limbeck, S; Galla, K; Bockstahler, B

    2013-12-01

    The aim of this study was to evaluate the pressure distribution under three different types of harnesses used for guide dogs (designated H1, H2 and H3). The dogs (n = 8) led a trainer through a course including a range of exercises (straight line, curve left, curve right, upstairs and downstairs). All dogs were clinically sound and showed no sign of lameness. The pressures beneath the harnesses were determined by sensor strips and related to the gait. In all harnesses, the highest pressures were found in the right sternal region (H1 2.02 ± 0.6N/cm(2); H2 1.76 ± 0.4N/cm(2); H3 1.14 ± 0.5 N/cm(2)). In all other regions, the pressures were in the range of 0-1.32 N/cm(2). The right and left sternal regions were almost constantly loaded. Contrary to previous assumptions, the back regions had minimal loading. This investigation demonstrated that there were significant differences among the harnesses. Copyright © 2013 Elsevier Ltd. All rights reserved.

  2. Harnessing the power of South-South partnerships to build capacity ...

    African Journals Online (AJOL)

    15, No. 1, June 2017. 8. Harnessing the power of South-South partnerships to build capacity for the prevention of sexual and intimate partner violence ... Sexual Violence Research Initiative, South African Medical Research Council ... programmes on IPV prevention and transforming men and masculinities show promise.

  3. Optimizing the Respiratory Pump: Harnessing Inspiratory Resistance to Treat Systemic Hypotension

    Science.gov (United States)

    2011-06-01

    error values. All the differences are statistically significant. (Adapted from Reference 14.) HARNESSING INSPIRATORY RESISTANCE TO TREAT SYSTEMIC...points represent the mean values. The error bars represent the standard error values. All the differences were statistically significant. (Adapted from...breathing Yes NA Yes Acute lung injury NA Yes Yes Penetrating chest trauma Yes Yes Yes Hypoxemia despite supplemental oxygen NA Yes Unknown

  4. Taso Mähar : "Ma ei kujunda endale ausammast" / Gitte Hint

    Index Scriptorium Estoniae

    Hint, Gitte

    2003-01-01

    Taso Mähar (sünd. 1962) kodu ja ühiskondlike ruumide sisekujunduse projekteerimisest, sisekujunduses tema jaoks olulisest, klientidest, arhitektuurialastest teadmistest Eestis. T. Mäharist, omistatud preemiad. 2000. aastast töötab arhitektuuribüroos Emil Urbel. Ill.: T. Mähari värv. portree

  5. How is knowledge co-produced in dialogue through the harnessing of “difference”?

    DEFF Research Database (Denmark)

    Phillips, Louise Jane; Olesen, Birgitte Ravn; Nielsen, Jørgen Lerche

    in dialogue. By harnessing difference as a transformative force, it is claimed, dialogue can generate knowledge across differences, including differences of organizational and professional position, theoretical perspective, gender, ethnicity, class and so on. But how exactly is knowledge co......-produced in dialogue through the harnessing of “difference” in organisational contexts? The papers in this panel address this question by drawing on Bakhtinian dialogic communication theory and other theories in analysis of what is at stake in the “co” of co-production in a range of different fields of practice – co......This panel is about the “dialogic turn” in the production and communication of knowledge, a general societal tendency in which practices of co-creation are widespread across diverse fields of social practice as a means of generating knowledge, often with a view to practice change. Practices of co...

  6. Toxic but drank: gustatory aversive compounds induce post-ingestional malaise in harnessed honeybees.

    Directory of Open Access Journals (Sweden)

    Ainara Ayestaran

    Full Text Available BACKGROUND: Deterrent substances produced by plants are relevant due to their potential toxicity. The fact that most of these substances have an unpalatable taste for humans and other mammals contrasts with the fact that honeybees do not reject them in the range of concentrations in which these compounds are present in flower nectars. Here we asked whether honeybees detect and ingest deterrent substances and whether these substances are really toxic to them. RESULTS: We show that pairing aversive substances with an odor retards learning of this odor when it is subsequently paired with sucrose. Harnessed honeybees in the laboratory ingest without reluctance a considerable volume (20 µl of various aversive substances, even if some of them induce significant post-ingestional mortality. These substances do not seem, therefore, to be unpalatable to harnessed bees but induce a malaise-like state that in some cases results in death. Consistently with this finding, bees learning that one odor is associated with sugar, and experiencing in a subsequent phase that the sugar was paired with 20 µl of an aversive substance (devaluation phase, respond less than control bees to the odor and the sugar. Such stimulus devaluation can be accounted for by the malaise-like state induced by the aversive substances. CONCLUSION: Our results indicate that substances that taste bitter to humans as well as concentrated saline solutions base their aversive effect on the physiological consequences that their ingestion generates in harnessed bees rather than on an unpalatable taste. This conclusion is only valid for harnessed bees in the laboratory as freely-moving bees might react differently to aversive compounds could actively reject aversive substances. Our results open a new possibility to study conditioned taste aversion based on post-ingestional malaise and thus broaden the spectrum of aversive learning protocols available in honeybees.

  7. World Bank: harnessing civil society expertise in undertaking and disseminating research findings.

    Science.gov (United States)

    Simms, Ben

    2013-01-01

    The UK Consortium on AIDS and International Development was an essential partner to the evaluation leaders in harnessing the contribution and expertise of civil society. This article describes what the partnership entailed, the additional value it brought and how civil society might use the evaluation findings both as a tool for advocacy and a means for improving its own engagement with the individuals directly affected by HIV and with those who care for them.

  8. Application Layer Definition and Analyses of Controller Area Network Bus for Wire Harness Assembly Machine

    OpenAIRE

    Guo, Hui; Jiang, Ying

    2006-01-01

    With the feature of multi-master bus access, nondestructive contention-based arbitration and flexible configuration, Controller Area Network (CAN) bus is applied into the control system of Wire Harness Assembly Machine (WHAM). To accomplish desired goal, the specific features of the CAN bus is analyzed by compared with other field buses and the functional performances in the CAN bus system of WHAM is discussed. Then the application layer planning of CAN bus for dynamic priority is presented. ...

  9. The relevance of netnography to the harness of Romanian health care electronic word-of-mouth

    OpenAIRE

    Bratucu, R; Gheorghe, IR; Radu, A.; Purcarea, VL

    2014-01-01

    Abstract Nowadays, consumers use the computer mediated communication to make purchase decisions on a large variety of products and services. Since health care services are archetypal by nature, consumers in this field are one of the most encountered users of electronic word-of-mouth. The objective of this paper is to explain and support the necessity of adopting a different qualitative method when electronic word of mouth is harnessed on health care dedicated forums, that is, netnography.

  10. The relevance of netnography to the harness of Romanian health care electronic word-of-mouth.

    Science.gov (United States)

    Bratucu, R; Gheorghe, I R; Radu, A; Purcarea, V L

    2014-09-15

    Nowadays, consumers use the computer mediated communication to make purchase decisions on a large variety of products and services. Since health care services are archetypal by nature, consumers in this field are one of the most encountered users of electronic word-of-mouth. The objective of this paper is to explain and support the necessity of adopting a different qualitative method when electronic word of mouth is harnessed on health care dedicated forums, that is, netnography.

  11. Følelser, fiktion – og Facebook - har erobret den politiske arena

    DEFF Research Database (Denmark)

    Aagaard, Peter

    2016-01-01

    Er der ét træk de nye politiske bevægelser – fra Trump til Alternativet – har til fælles, er det evnen til at fortælle historier, vælgerne kan koble sig på som medfortællere. Historier om håb og frelse, fornedrelse og fortabelse. Det bringer drømmene og magien tilbage i politik. Derfor vinder de ...

  12. The Belem Framework for Action: Harnessing the Power and Potential of Adult Learning and Education for a Viable Future

    Science.gov (United States)

    Adult Learning, 2012

    2012-01-01

    This article presents the Belem Framework for Action. This framework focuses on harnessing the power and potential of adult learning and education for a viable future. This framework begins with a preamble on adult education and towards lifelong learning.

  13. Development of an alternative five-point restraint harness to accommodate children with special healthcare needs in child safety seats.

    Science.gov (United States)

    Brinkey, Lori; Manary, Miriam; Santioni, Daniel

    2011-01-01

    Commercial automotive child restraint systems (CRSs) do not accommodate all children with special healthcare needs. This study developed an alternative harness for a commercial CRS to meet the needs of children for whom a five-point harness cannot be positioned over medically involved areas and/or children whose conditions require the harness belts to be threaded through medical devices. After initial design work and a series of frontal sled-impact tests, one of two prototype designs was chosen for fit testing on children with and without healthcare conditions. After a minor modification, additional sled-impact testing was conducted to determine compliance of the system to federal standards. The CRS with alternate harness provides good fit to children with a variety of healthcare needs and complies with all performance criteria of FMVSS 213, with the exception of peak forward head excursion using the Hybrid III 6-year-old crash-test dummy. It is expected that all performance criteria will be met using the newly-issued federal allowance to conduct CRS frontal-impact tests using an earlier version of the dummy. The new harness shows promise as a low-cost solution for achieving a safer level of transportation for children who may otherwise travel unrestrained or with a severely misused CRS harness.

  14. Different DMRT3 Genotypes Are Best Adapted for Harness Racing and Riding in Finnhorses.

    Science.gov (United States)

    Jäderkvist Fegraeus, Kim; Johansson, Lisa; Mäenpää, Minna; Mykkänen, Anna; Andersson, Lisa S; Velie, Brandon D; Andersson, Leif; Árnason, Thorvaldur; Lindgren, Gabriella

    2015-01-01

    Previous studies showed a positive effect of the DMRT3 "gait keeper" mutation on harness racing performance in Standardbreds, French-, and Nordic trotters. The mutation has also been shown to influence riding traits in multiple breeds. This study investigated the effect of the DMRT3 mutation on harness racing performance and riding traits in Finnhorses. Finnhorses used for harness racing (n = 180) and for riding (n = 59) were genotyped for the DMRT3 mutation. For the trotters the genotypes were evaluated for association with racing performance (number of starts, victories, placings, earnings, and race times). At 3-6 years of age the AA genotype was superior compared with the CA and CC genotypes. The AA horses had a significantly higher proportion of victories (P = 1.4×10(-6)) and placings (P = 4.1×10(-7)), better race times (P = 0.01), and earned more money (P = 0.009) compared with C-horses. For the Finnhorses used for riding the owners answered a questionnaire to score how well the horse performed the gaits walk, trot, and canter on a scale from 1 to 6. These scores were tested for association with the DMRT3 genotypes. Although AA horses were more successful as racehorses, the CC and CA horses appear more adapted for classical riding disciplines. The AA horses received significantly lower gait scores compared with C-horses for the majority of gaits. Except for rhythm in extended canter (P = 0.05), there were no significant differences between CA and CC horses. This study shows that there are different optimal genotypes for different disciplines and the DMRT3 mutation clearly influences gaits and performance in Finnhorses. © The American Genetic Association. 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  15. A novel approach for harnessing biofilm communities in moving bed biofilm reactors for industrial wastewater treatment

    Directory of Open Access Journals (Sweden)

    Joe A. Lemire

    2015-10-01

    Full Text Available Moving bed biofilm reactors (MBBRs are an effective biotechnology for treating industrial wastewater. Biomass retention on moving bed biofilm reactor (MBBR carriers (biofilm support materials, allows for the ease-of-operation and high treatment capacity of MBBR systems. Optimization of MBBR systems has largely focused on aspects of carrier design, while little attention has been paid to enhancing strategies for harnessing microbial biomass. Previously, our research group demonstrated that mixed-species biofilms can be harvested from an industrial wastewater inoculum [oil sands process water (OSPW] using the Calgary Biofilm Device (CBD. Moreover, the resultant biofilm communities had the capacity to degrade organic toxins (naphthenic acids—NAs that are found in OSPW. Therefore, we hypothesized that harnessing microbial communities from industrial wastewater, as biofilms, on MBBR carriers may be an effective method to bioremediate industrial wastewater.Here, we detail our methodology adapting the workflow employed for using the CBD, to generate inoculant carriers to seed an MBBR.In this study, OSPW-derived biofilm communities were successfully grown, and their efficacy evaluated, on commercially available MBBR carriers affixed within a modified CBD system. The resultant biofilms demonstrated the capacity to transfer biomass to recipient carriers within a scaled MBBR. Moreover, MBBR systems inoculated in this manner were fully active 2 days post-inoculation, and readily degraded a select population of NAs. Together, these findings suggest that harnessing microbial communities on carriers affixed within a modified CBD system may represent a facile and rapid method for obtaining functional inoculants for use in wastewater MBBR treatment systems.

  16. Kvote 2 optagelse og akademiske præstationer: Hvor stor betydning har det adgangsgivende eksamenssnit?

    Directory of Open Access Journals (Sweden)

    Lotte Dyhrberg ONeill

    2013-03-01

    Full Text Available Kvote 2 optagelse (optagelsesprøver til medicinstudiet har vist sig at have virket beskyttende på tidligt studiefrafald sammenlignet med kvote 1 optagelse på Syddansk Universitet. Dette prospektive kohorte studie af de samme kohorter viser, at de lavere adgangsgivende karakterer i kvote 2 gruppen samtidigt kun var forbundet med lidt lavere bachelor karaktergennemsnit. Admission testing appears to be protective against early dropout compared to grade-based admission for undergraduate medical students at the University of Southern Denmark. This prospective cohort study shows that the lower entry grades of the admission tested students were simultaneously associated with obtaining only slightly lower medical school grades.

  17. A battery-less photo-detector enabled with simultaneous ferroelectric sensing and energy harnessing mechanism

    Science.gov (United States)

    Lai, Szu Cheng; Yao, Kui; Chen, Yi Fan

    2013-08-01

    A self-sustainable mechanism for simultaneously sensing and harnessing photon energy was proposed and implemented to create a battery-less and wire-less ultraviolet sensor made of ferroelectric lead lanthanum zirconate titanate thin film with in-plane polarization configuration. The mechanism involved accumulating and storing the photovoltaic charge, and transferring the stored charge via a piezoelectric switch to a radio frequency transmitter. The time-interval between the radio frequency pulses generated by the transmitter was inversely proportional to the photo-intensity. The sustainability of the operation was ascribed to the low leakage, high photovoltage, and linear current-voltage characteristics of ferroelectric sensing material instead of semiconductors.

  18. Deaf Workers in Restaurant, Retail, and Hospitality Sector Employment: Harnessing Research to Promote Advocacy.

    Science.gov (United States)

    Stokar, Hayley

    2017-01-01

    A quarter-century after the passage of the Americans with Disabilities Act (ADA, 1990 ), workplace accommodation is still a struggle for deaf employees and their managers. Many challenges are the result of communication barriers that can be overcome through much needed-although often absent-advocacy and training. This article highlights the literature on the employment of deaf individuals in the United States service industries of food service, retail, and hospitality conducted from 2000 to 2016. Exploring dimensions of both hiring and active workplace accommodation, suggestions are made for how social work advocates can harness information and strengthen their approaches for educating managers and supporting workers.

  19. Handbook of Pressure-Proof Connector and Cable Harness Design for Sonar Systems.

    Science.gov (United States)

    1981-12-21

    Harnesses 203-442-0771 J. Orr Penetrators E. Racine Materials R. Gerlipp T. Mapes R. Maple G. De La Cruz E. Pearson H. Malootian R. DeAngelis C. LeBlanc...Sherman (1) ATTN: Code 967.73, W.W. Lovell (6) Code 316, T.J. Mapes (1) Code 270, A. Bratt (1) Code 316, R. DeAngelis (1) d 2Code 3232, G. Connolly (1...kesearch Institute, Inc. S. Modlin (1) 5902 West Bee Caves Rd. D. G. O’Brien, Inc. Austin, TX 78746 PO Box 159 ATTN: Donald E. Glowe (1) Seabrook, NH

  20. Potential of mixed microalgae to harness biodiesel from ecological water-bodies with simultaneous treatment.

    Science.gov (United States)

    Mohan, S Venkata; Devi, M Prathima; Mohanakrishna, G; Amarnath, N; Babu, M Lenin; Sarma, P N

    2011-01-01

    Biodiesel as an eco-friendly fuel is gaining much acceptance in recent years. This communication provides an overview on the possibility of using mixed microalgae existing in ecological water-bodies for harnessing biodiesel. Microalgal cultures from five water-bodies are cultivated in domestic wastewater in open-ponds and the harvested algal-biomass was processed through acid-catalyzed transesterification. Experiments evidenced the potential of using mixed microalgae for harnessing biodiesel. Presence of palmitic acid (C16:0) in higher fraction and physical properties of algal oil correlated well with the biodiesel properties. Functional characteristics of water-bodies showed to influence both species diversity and lipid accumulation. Microalgae from stagnant water-bodies receiving domestic discharges documented higher lipid accumulation. Algal-oil showed to consist 33 types of saturated and unsaturated fatty acids having wide food and fuel characteristics. Simultaneous wastewater treatment was also noticed due to the syntrophic association in the water-body microenvironment. Diversity studies visualized the composition of algae species known to accumulate higher lipids. Copyright © 2010 Elsevier Ltd. All rights reserved.

  1. Plug-and-play design approach to smart harness for modular small satellites

    Science.gov (United States)

    Mughal, M. Rizwan; Ali, Anwar; Reyneri, Leonardo M.

    2014-02-01

    A typical satellite involves many different components that vary in bandwidth demand. Sensors that require a very low data rate may reside on a simple two- or three-wire interface such as I2C, SPI, etc. Complex sensors that require high data rate and bandwidth may reside on an optical interface. The AraMiS architecture is an enhanced capability architecture with different satellite configurations. Although keeping the low-cost and COTS approach of CubeSats, it extends the modularity concept as it also targets different satellite shapes and sizes. But modularity moves beyond the mechanical structure: the tiles also have thermo-mechanical, harness and signal-processing functionalities. Further modularizing the system, every tile can also host a variable number of small sensors, actuators or payloads, connected using a plug-and-play approach. Every subsystem is housed in a small daughter board and is supplied, by the main tile, with power and data distribution functions, power and data harness, mechanical support and is attached and interconnected with space-grade spring-loaded connectors. The tile software is also modular and allows a quick adaptation to specific subsystems. The basic software for the CPU is properly hardened to guarantee high level of radiation tolerance at very low cost.

  2. Effects of harness transmitters on behavior and reproduction of wild mallards

    Science.gov (United States)

    Pietz, Pamela J.; Krapu, Gary L.; Greenwood, Raymond J.; Lokemoen, John T.

    1993-01-01

    Radio telemetry has been an important research tool in waterfowl studies for >20 years, yet little effort has been made to evaluate potential effects of transmitters on the birds that carry them. As part of a 4-year mallard (Anas platyrhynchos) study in the prairie pothole region of North Dakota and Minnesota, we compared radio-marked and unmarked female mallards in terms of percent time observed feeding, resting, and preening; nest initiation date; and clutch size and egg volume. Radio-marked females carried a 23-g back-mounted transmitter attached with a 2-loop harness (Dwyer 1972). On average, radio-marked females tended to feed less, rest and preen more, initiate nests later, and lay smaller clutches and eggs than unmarked females. Thus, behavioral and reproductive data from ducks marked with back-mounted harness-attached transmitters may be biased. We recommend that new designs of radio packages be field tested and caution that effects may be masked under extreme environmental conditions.

  3. Research on the Statistical Characteristics of Crosstalk in Naval Ships Wiring Harness Based on Polynomial Chaos Expansion Method

    Directory of Open Access Journals (Sweden)

    Chi Yaodan

    2017-08-01

    Full Text Available Crosstalk in wiring harness has been studied extensively for its importance in the naval ships electromagnetic compatibility field. An effective and high-efficiency method is proposed in this paper for analyzing Statistical Characteristics of crosstalk in wiring harness with random variation of position based on Polynomial Chaos Expansion (PCE. A typical 14-cable wiring harness was simulated as the object of research. Distance among interfering cable, affected cable and GND is synthesized and analyzed in both frequency domain and time domain. The model of naval ships wiring harness distribution parameter was established by utilizing Legendre orthogonal polynomials as basis functions along with prediction model of statistical characters. Detailed mean value, mean square error, probability density function and reasonable varying range of crosstalk in naval ships wiring harness are described in both time domain and frequency domain. Numerical experiment proves that the method proposed in this paper, not only has good consistency with the MC method can be applied in the naval ships EMC research field to provide theoretical support for guaranteeing safety, but also has better time-efficiency than the MC method. Therefore, the Polynomial Chaos Expansion method.

  4. Continental temperatures through the early Eocene in western central Europe

    Science.gov (United States)

    Inglis, G. N.; Collinson, M. E.; Riegel, W.; Wilde, V.; Farnsworth, A.; Lunt, D. J.; Robson, B.; Scott, A. C.; Lenz, O.; Pancost, R.

    2016-12-01

    In contrast to the marine realm, our understanding of terrestrial temperature change during greenhouse climates is poorly constrained. Recently, branched glycerol dialkyl glycerol tetraethers (brGDGTs) have been used to successfully reconstruct mean annual air temperature (MAAT) during the early Paleogene. However, despite the potential to provide new insights into terrestrial climate, the application of this proxy in lignite and coal deposits is still limited. Using samples recovered from Schöningen, Germany ( 48°N), we provide the first detailed study into the occurrence and distribution of brGDGTs through a sequence of Early Eocene lignites and associated marine interbeds. Branched GDGTs are abundant and present in every sample. In comparison to modern studies, changes in vegetation type do not appear to significantly impact brGDGT distributions; however, there are subtle differences in these distributions between lignites and siliciclastic nearshore marine interbed sediments. Using the most recent brGDGT temperature calibration, we generate the first continental temperature record from central-western continental Europe through the Early Eocene. Lignite-derived MAAT estimates range from 23 to 26°C and those derived from the nearshore marine interbeds always exceed 20°C. These estimates are consistent with other mid-latitude palaeoclimate proxy records which indicate enhanced early Eocene warmth. In the basal part of the section, warming is recorded in both the lignites ( 2°C) and nearshore marine interbeds ( 2-3°C). This culminates in a long-term temperature maximum, likely including the Early Eocene Climatic Optimum (EECO). Although this trend is relatively well established in marginal marine sediments within the SW Pacific, it has rarely been shown in other regions or terrestrial settings. Using a suite of new climate model simulations, our warming trend is consistent with a doubling of CO2 (from 560ppmv to 1120ppmv) which broadly agrees with proxy-derived CO2 estimates from the early Paleogene

  5. Evaluation of extensive floods in western/central Europe

    Czech Academy of Sciences Publication Activity Database

    Gvoždíková, B.; Müller, Miloslav

    2017-01-01

    Roč. 21, č. 7 (2017), s. 3715-3725 ISSN 1027-5606 R&D Projects: GA ČR GA17-23773S Institutional support: RVO:68378289 Keywords : June 2013 flood * extreme floods * river-basin * climate * events * precipitation * Germany * Britain * example * model Subject RIV: DG - Athmosphere Sciences, Meteorology OBOR OECD: Meteorology and atmospheric sciences Impact factor: 4.437, year: 2016 https://www.hydrol-earth-syst-sci.net/21/3715/2017/hess-21-3715-2017.pdf

  6. Evaluation of extensive floods in western/central Europe

    Directory of Open Access Journals (Sweden)

    B. Gvoždíková

    2017-07-01

    Full Text Available This paper addresses the identification and evaluation of extreme flood events in the transitional area between western and central Europe in the period 1951–2013. Floods are evaluated in terms of three variants on an extremity index that combines discharge values with the spatial extent of flooding. The indices differ in the threshold of the considered maximum discharges; the flood extent is expressed by a length of affected river network. This study demonstrates that using the index with a higher flood discharge limit changes the floods' rankings significantly. It also highlights the high severity events. In general, we detected an increase in the proportion of warm half-year floods when using a higher discharge limit. Nevertheless, cold half-year floods still predominate in the lists because they generally affect large areas. This study demonstrates the increasing representation of warm half-year floods from the northwest to the southeast.

  7. Ipsilateral Scapular Cutaneous Anchor System: An alternative for the harness in body-powered upper-limb prostheses.

    Science.gov (United States)

    Hichert, Mona; Plettenburg, Dick H

    2017-03-01

    Body-powered prosthesis users frequently complain about the poor cosmesis and comfort of the traditional shoulder harness. The Ipsilateral Scapular Cutaneous Anchor System offers an alternative, but it remains unclear to what extent it affects the perception and control of cable operation forces compared to the traditional shoulder harness. To compare cable force perception and control with the figure-of-nine harness versus the Ipsilateral Scapular Cutaneous Anchor System and to investigate force perception and control at different force levels. Experimental trial. Ten male able-bodied subjects completed a cable force reproduction task at four force levels in the range of 10-40 N using the figure-of-nine harness and the Anchor System. Perception and control of cable operating forces were quantified by the force reproduction error and the force variability. In terms of force reproduction error and force variability, the subjects did not behave differently when using the two systems. The smallest force reproduction error and force variability were found at the smallest target force level of 10 N. The Anchor System performs no differently than the traditional figure-of-nine harness in terms of force perception and control, making it a viable alternative. Furthermore, users perceive and control low operation forces better than high forces. Clinical relevance The Ipsilateral Scapular Cutaneous Anchor System offers an alternative for the traditional harness in terms of cable operation force perception and control and should therefore be considered for clinical use. Low cable operation forces increase the perception and control abilities of users.

  8. Tectonothermal evolution of the Triassic flysch in the Bayan Har Orogen, Tibetan plateau

    Science.gov (United States)

    Wang, Hejing; Rahn, Meinert; Zhou, Jian

    2018-01-01

    The Bayan Har Orogen comprises a major part of the "Qingzang-Dianxi fold region" in western China. It preserves important information of the tectono-thermal evolution covering the time span from the closure of the Paleo-Tethys Ocean up to the formation of the Himalayas. Low temperature metamorphic indicators, such as mineral assemblages, illite "crystallinity" (IC), chlorite "crystallinity" (CC), illite polytype, b-cell dimension of K-white micas, geothermometry of selected minerals were analyzed. The values of Kübler index (KI) of the Triassic flysch in the Bayan Har Orogen range from 0.23-1.63°Δ2θ while Árkai index (ÁI) in a range of 0.21-0.60°Δ2θ. Iso-thermal zones mapped with KI describe a pair of anchizones and an anchiregion within the Bayan Har Orogen: the "Giant Yushu Anchizone" in the southwest (extending > 750 km long and 100 km wide), the "Zaling-Eling-Lakes Anchizone" in the center (about 150 km long and 40 km wide) and the "Xing-Tong-Zhe Anchiregion" in the northeast (covering an area of roughly 60,000 km2). They are separated by diagenetic zones. Peak metamorphic conditions are estimated around 280-330 °C and a low to intermediate (N. New Hampshire) pressure type. A slight change with increasing then decreasing pressure was observed from SW to NE. The relationship between anchimetamorphic pattern of Triassic flysch and large-scale folds and faults indicates syn- to post structural metamorphism. Compression at the end of the Triassic, induced by the interaction of the Tarim, North China and Indian blocks caused the closure of the Paleo-Tethys Ocean and led to the folding of the Triassic flysch within the Paleo-Tethys Ocean basin. Anchimetamorphism may have been caused by crustal thickening of > 10 km due to an accretionary wedge setting and a temperature increase in those rocks due to burial. Such a regional metamorphic pattern would provide important information for reconstruction of palaeotectonic-palaeogeograph and the evolutionary history

  9. Trump har droppet fløjlshandskerne, nu da han er slået tilbage til start

    DEFF Research Database (Denmark)

    Hendricks, Vincent Fella

    2016-01-01

    Donald Trump vandt primærvalget ved hjælp af personangreb. I præsidentvalgkampens slutspurt har han nu taget den strategi op igen, selvom alle dømte den ude – og det er måske slet ikke så dumt, for det er det, Trump kan......Donald Trump vandt primærvalget ved hjælp af personangreb. I præsidentvalgkampens slutspurt har han nu taget den strategi op igen, selvom alle dømte den ude – og det er måske slet ikke så dumt, for det er det, Trump kan...

  10. How is knowledge co-produced in dialogue through the harnessing of “difference”?

    DEFF Research Database (Denmark)

    Phillips, Professor MSO Louise; Jakobsen, Helle Nordentoft; Olesen, Lektor Birgitte Ravn

    -producers of knowledge, as opposed to clients, informants, consumers, students or target groups. According to dialogic ideals, expert knowledge is democratized as multiple ways of knowing are recognized as legitimate. Crucially, difference is viewed as the transformative force in the co-construction of knowledge...... in dialogue. By harnessing difference as a transformative force, it is claimed, dialogue can generate knowledge across differences, including differences of organizational and professional position, theoretical perspective, gender, ethnicity, class and so on. But how exactly is knowledge co...... with tensions emanating from the play of power in which certain knowledge forms and subjectivities dominate and others are marginalised or excluded. And those tensions are shaped by the complexities of working across different knowledge forms and expectations in relation to the process and outcome in particular...

  11. Harnessing type I and type III CRISPR-Cas systems for genome editing

    DEFF Research Database (Denmark)

    Li, Yingjun; Pan, Saifu; Zhang, Yan

    2016-01-01

    CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated) systems are widespread in archaea and bacteria, and research on their molecular mechanisms has led to the development of genome-editing techniques based on a few Type II systems. However, there has not been any...... report on harnessing a Type I or Type III system for genome editing. Here, a method was developed to repurpose both CRISPR-Cas systems for genetic manipulation in Sulfolobus islandicus, a thermophilic archaeon. A novel type of genome-editing plasmid (pGE) was constructed, carrying an artificial mini-CRISPR...... and selectively retained as transformants. Using this strategy, different types of mutation were generated, including deletion, insertion and point mutations. We envision this method is readily applicable to different bacteria and archaea that carry an active CRISPR-Cas system of DNA interference provided...

  12. 60 år med EU har reddet de europæiske nationalstater

    DEFF Research Database (Denmark)

    Wind, Marlene

    2017-01-01

    Professor og leder af Center for Europæisk politik, Marlene Wind, havde lørdag den 10. marts en kronik i Berlingske under overskriften ”60 år med EU har reddet de europæiske nationalstater”. Kronikken gennemgår både de kommende Europæiske valg, og hvilken indvirkning det kan tænkes at have på EU,......, hvad der kan forklare Brexit, og hvordan fremtiden ser ud for briterne. En fremtid der tyder på at blive både dyr og alt andet, end hvad Leave-vælgerne nok forventede, da de satte deres kryds....

  13. Let our powers combine! Harnessing NASA's Earth Observatory Natural Event Tracker (EONET) in Worldview

    Science.gov (United States)

    Wong, M. M.; Ward, K.; Boller, R. A.; Gunnoe, T.; Baynes, K.; King, B. A.

    2016-12-01

    Constellations of NASA Earth Observing System (EOS) satellites orbit the earth to collect images and data about the planet in near real-time. Within hours of satellite overpass, you can discover where the latest wildfires, severe storms, volcanic eruptions, and dust and haze events are occurring using NASA's Worldview web application. By harnessing a repository of curated natural event metadata from NASA Earth Observatory's Natural Event Tracker (EONET), Worldview has moved natural event discovery to the forefront and allows users to select events-of-interest from a curated list, zooms to the area, and adds the most relevant imagery layers for that type of natural event. This poster will highlight NASA Worldview's new natural event feed functionality.

  14. Harnessing big data for estimating the energy consumption and driving range of electric vehicles

    DEFF Research Database (Denmark)

    Fetene, Gebeyehu Manie; Kaplan, Sigal; Mabit, Stefan Lindhard

    2017-01-01

    electric vehicles (BEVs) and provides insight into the factors that affect their energy consumption by harnessing big data from real-world driving. The analysis relied on four data sources: (i) driving patterns collected from 741 drivers over a two-year period; (ii) drivers’ characteristics; (iii) road...... type; (iv) weather conditions. The results of the analysis measure the mean ECR of BEVs at 0.183 kW h/km, underline a 34% increase in ECR and a 25% decrease in driving range in the winter with respect to the summer, and suggest the electricity tariff for BEVs to be cost efficient with respect...... to conventional ones. Moreover, the results of the analysis show that driving speed, acceleration and temperature have non-linear effects on the ECR, while season and precipitation level have a strong linear effect. The econometric model of the ECR of BEVs suggests that the optimal driving speed is between 45...

  15. Harnessing Vehicle Automation for Public Mobility -- An Overview of Ongoing Efforts

    Energy Technology Data Exchange (ETDEWEB)

    Young, Stanley E.

    2015-11-05

    This presentation takes a look at the efforts to harness automated vehicle technology for public transport. The European CityMobil2 is the leading demonstration project in which automated shuttles were, or are planned to be, demonstrated in several cities and regions. The presentation provides a brief overview of the demonstrations at Oristano, Italy (July 2014), LaRochelle, France (Dec 2014), Lausanne, Switzerland (Apr 2015), Vantaa, Finland (July 2015), and Trikala, Greece (Sept 2015). In addition to technology exposition, the objectives included generating a legal framework for operation in each location and gaging the reaction of the public to unmanned shuttles, both of which were successfully achieved. Several such demonstrations are planned throughout the world, including efforts in North America in conjunction with the GoMentum Station in California. These early demonstration with low-speed automated shuttles provide a glimpse of the possible with a fully automated fleet of driverless vehicle providing a public transit service.

  16. Let Our Powers Combine! Harnessing NASA's Earth Observatory Natural Event Tracker (EONET) in Worldview

    Science.gov (United States)

    Wong, Min Minnie; Ward, Kevin; Boller, Ryan; Gunnoe, Taylor; Baynes, Kathleen; King, Benjamin

    2016-01-01

    Constellations of NASA Earth Observing System (EOS) satellites orbit the earth to collect images and data about the planet in near real-time. Within hours of satellite overpass, you can discover where the latest wildfires, severe storms, volcanic eruptions, and dust and haze events are occurring using NASA's Worldview web application. By harnessing a repository of curated natural event metadata from NASA Earth Observatory's Natural Event Tracker (EONET), Worldview has moved natural event discovery to the forefront and allows users to select events-of-interest from a curated list, zooms to the area, and adds the most relevant imagery layers for that type of natural event. This poster will highlight NASA Worldviews new natural event feed functionality.

  17. The sweetest pill to swallow: how patient neurobiology can be harnessed to maximise placebo effects.

    Science.gov (United States)

    Jubb, Jayne; Bensing, Jozien M

    2013-12-01

    The burgeoning interest in placebo effects over the last 10-15 years has fallen into two main research areas: elucidation of the neurobiological mechanisms recruited following placebo administration, and investigations into the situations and contexts in which placebo effects are evoked. There has been little attention focused on bridging these two i.e. how to actively translate and apply these neurobiological mechanisms into daily clinical practice in a responsible way. This article addresses this gap, first through a narrative review of the last 15 years of neuroscience findings with special attention focussed on the elucidation of the neurotransmitters, pathways and mechanisms involved in placebo effects, and secondly, at how these psycho(neuro)biological effects could be harnessed in medical care. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. HARNESSING THE HUMAN POTENTIAL TEAMS IN CO-OPERATIVE ORGANIZATIONS IN THE LIGHT OF EUROPEAN MANAGEMENT

    Directory of Open Access Journals (Sweden)

    GRAUR Elena

    2017-06-01

    Full Text Available Human potential was and is among the most valuable resources that each organization has, and also one of the decisive resources for an efficient business activity and its evolution in performance. All management functions are performed by people while success or failure of the management activity depends on acquiring the art of working with people. When the top managers succeed to harness the potential of the employees so that they become not subordinates but teammates in the future activities of the organization, we can already speak about highly qualified professionals who generate sustainable development of the employing company. The research will mainly focus on the comparative study of approaches practiced in European countries along with co-operative enterprises from our country, researching the training level and theoretical-practical training provided by authorized institutions in these domains.

  19. Trunk Muscle Activation and Estimating Spinal Compressive Force in Rope and Harness Vertical Dance.

    Science.gov (United States)

    Wilson, Margaret; Dai, Boyi; Zhu, Qin; Humphrey, Neil

    2015-12-01

    Rope and harness vertical dance takes place off the floor with the dancer suspended from his or her center of mass in a harness attached to a rope from a point overhead. Vertical dance represents a novel environment for training and performing in which expected stresses on the dancer's body are different from those that take place during dance on the floor. Two male and eleven female dancers with training in vertical dance performed six typical vertical dance movements with electromyography (EMG) electrodes placed bilaterally on rectus abdominus, external oblique, erector spinae, and latissimus dorsi. EMG data were expressed as a percentage of maximum voluntary isometric contraction (MVIC). A simplified musculoskeletal model based on muscle activation for these four muscle groups was used to estimate the compressive force on the spine. The greatest muscle activation for erector spinae and latissimus dorsi and the greatest trunk compressive forces were seen in vertical axis positions where the dancer was moving the trunk into a hyper-extended position. The greatest muscle activation for rectus abdominus and external oblique and the second highest compressive force were seen in a supine position with the arms and legs extended away from the center of mass (COM). The least muscle activation occurred in positions where the limbs were hanging below the torso. These movements also showed relatively low muscle activation compression forces. Post-test survey results revealed that dancers felt comfortable in these positions; however, observation of some positions indicated insufficient muscular control. Computing the relative contribution of muscles, expressed as muscle activation and estimated spinal compression, provided a measure of how much the muscle groups were working to support the spine and the rest of the dancer's body in the different movements tested. Additionally, identifying typical muscle recruitment patterns in each movement will help identify key exercises

  20. Localization of distinct surface antigens on Chlamydia trachomatis HAR-13 by immune electron microscopy with monoclonal antibodies.

    Science.gov (United States)

    Clark, R B; Nachamkin, I; Schatzki, P F; Dalton, H P

    1982-01-01

    Monoclonal antibodies were produced against the HAR-13 strain (A) of Chlamydia trachomatis. By an indirect immunofluorescence technique, three clones (1-7, 2-8, 9F) were found to produce antibody that reacted only with serotype A strains. Clone 3-5 produced antibody that cross-reacted with serotypes A, C, H, I, and J. Using an indirect immunoferritin technique, we examined the binding of these antibodies to strain HAR-13 by electron microscopy. Antibodies from all four clones were shown to bind to the outer membrane surface of both reticulate and elementary bodies. Two distinct binding patterns were demonstrated. Antibodies from clones 1-7 and 9F bound to the outer membrane surface in a homogeneous pattern, whereas antibodies 2-8 and 3-5 bound to the outer membrane surface in an irregular, patchy distribution. There was a direct correlation between the distribution of antigen on the outer membrane surface and neutralization of C. trachomatis HAR-13 infectivity in vitro. Neutralization of HAR-13 infectivity by antibodies 1-7 and 9F was complement dependent, whereas antibodies 2-8 and 3-5 did not neutralize under any conditions. Images PMID:7152670

  1. Harnessing the Potential of ICTs: Literacy and Numeracy Programmes Using Radio, TV, Mobile Phones, Tablets and Computers. 2nd Edition

    Science.gov (United States)

    Hanemann, Ulrike, Ed.; Scarpino, Cassandra, Ed.

    2016-01-01

    The UNESCO Institute for Lifelong Learning (UIL) has published a second edition of "Harnessing the Potential of ICTs: Literacy and Numeracy Programmes Using Radio, TV, Mobile Phones, Tablets and Computers." This compilation of case studies from all world regions presents promising literacy and numeracy programmes that use information and…

  2. Ipsilateral Scapular Cutaneous Anchor System : An alternative for the harness in body-powered upper-limb prostheses

    NARCIS (Netherlands)

    Hichert, M.; Plettenburg, D.H.

    2017-01-01

    Background: Body-powered prosthesis users frequently complain about the poor cosmesis and comfort of the traditional shoulder harness. The Ipsilateral Scapular Cutaneous Anchor System offers an alternative, but it remains unclear to what extent it affects the perception and control of cable

  3. Harnessing Technology for Promoting Undergraduate Art Education: A Novel Model That Streamlines Learning between Classroom, Museum, and Home

    Science.gov (United States)

    Kali, Yael; Sagy, Ornit; Kuflik, Tsvi; Mogilevsky, Orit; Maayan-Fanar, Emma

    2015-01-01

    We report on the development and evaluation of an innovative instructional model, which harnesses advanced technologies and local resources (an in-campus museum), to support undergraduate-level art history students in developing the skills required for analyzing artwork. Theory suggests that analyzing artwork requires theoretical knowledge and…

  4. "Elul ei ole lugu ..." = "Livet har ingen berättelse ..." : [luuletused] / Doris Kareva ; tlk. rootsi keelde Kalli Klement

    Index Scriptorium Estoniae

    Kareva, Doris, 1958-

    2003-01-01

    Sisu: "Elul ei ole lugu ..." = "Livet har ingen berättelse ..."; "Elu ja uni - kaks lehte ..." = "Liv och sömn-två blad ..."; "Linnusulega liivale ..." = "Med en fjäder i sanden ..."; "Ja ma armastan Sind, sest ..." = Och jag älskar Dig, därför att ..."

  5. Opportunities for high aspect ratio micro-electro-magnetic-mechanical systems (HAR-MEMMS) at Lawrence Berkeley Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Hunter, S. [ed.

    1993-10-01

    This report contains viewgraphs on the following topics: Opportunities for HAR-MEMMS at LBL; Industrial Needs and Opportunities; Deep Etch X-ray Lithography; MEMS Activities at BSAC; DNA Amplification with Microfabricated Reaction Chamber; Electrochemistry Research at LBL; MEMS Activities at LLNL; Space Microsensors and Microinstruments; The Advanced Light Source; Institute for Micromaching; IBM MEMS Interests; and Technology Transfer Opportunities at LBL.

  6. Transition through co-optation: Harnessing carbon democracy for clean energy

    Science.gov (United States)

    Meng, Kathryn-Louise

    This dissertation explores barriers to a clean energy transition in the United States. Clean energy is demonstrably viable, yet the pace of clean energy adoption in the U.S. is slow, particularly given the immediate threat of global climate change. The purpose of this dissertation is to examine the factors inhibiting a domestic energy transition and to propose pragmatic approaches to catalyzing a transition. The first article examines the current political-economic and socio-technical energy landscape in the U.S. Fossil fuels are central to the functioning of the American economy. Given this centrality, constellations of power have been constructed around the reliable and affordable access of fossil fuels. The fossil fuel energy regime is comprised of: political-economic networks with vested interests in continued fossil fuel reliance, and fixed infrastructure that is minimally compatible with distributed generation. A transition to clean energy threatens the profitability of fossil fuel regime actors. Harnessing structural critiques from political ecology and process and function-oriented socio-technical systems frameworks, I present a multi-level approach to identifying pragmatic means to catalyzing an energy transition. High-level solutions confront the existing structure, mid-level solutions harness synergy with the existing structure, and low-level solutions lie outside of the energy system or foster the TIS. This is exemplified using a case study of solar development in Massachusetts. Article two presents a case study of the clean energy technological innovation system (TIS) in Massachusetts. I examine the actors and institutions that support cleantech development. Further, I scrutinize the actors and institutions that help sustain the TIS support system. The concept of a catalyst is presented; a catalyst is an actor that serves to propel TIS functions. Catalysts are critical to facilitating anchoring. Strategic corporate partners are identified as powerful

  7. Harnessing genomics to improve health in the Eastern Mediterranean Region - an executive course in genomics policy.

    Science.gov (United States)

    Acharya, Tara; Rab, Mohammed Abdur; Singer, Peter A; Daar, Abdallah S

    2005-01-21

    BACKGROUND: While innovations in medicine, science and technology have resulted in improved health and quality of life for many people, the benefits of modern medicine continue to elude millions of people in many parts of the world. To assess the potential of genomics to address health needs in EMR, the World Health Organization's Eastern Mediterranean Regional Office and the University of Toronto Joint Centre for Bioethics jointly organized a Genomics and Public Health Policy Executive Course, held September 20th-23rd, 2003, in Muscat, Oman. The 4-day course was sponsored by WHO-EMRO with additional support from the Canadian Program in Genomics and Global Health. The overall objective of the course was to collectively explore how to best harness genomics to improve health in the region. This article presents the course findings and recommendations for genomics policy in EMR. METHODS: The course brought together senior representatives from academia, biotechnology companies, regulatory bodies, media, voluntary, and legal organizations to engage in discussion. Topics covered included scientific advances in genomics, followed by innovations in business models, public sector perspectives, ethics, legal issues and national innovation systems. RESULTS: A set of recommendations, summarized below, was formulated for the Regional Office, the Member States and for individuals.* Advocacy for genomics and biotechnology for political leadership;* Networking between member states to share information, expertise, training, and regional cooperation in biotechnology; coordination of national surveys for assessment of health biotechnology innovation systems, science capacity, government policies, legislation and regulations, intellectual property policies, private sector activity;* Creation in each member country of an effective National Body on genomics, biotechnology and health to:- formulate national biotechnology strategies- raise biotechnology awareness- encourage teaching and

  8. Deep Cenezoic Sediments in Front of the Barbados Ridge Complex, Odp Site 672: Hemipelagites, Turbidites, and Possible Contourites in Western Central Atlantic Ocean Sédiments cénozoïques au front du complexe de la Barbade, site ODP 672 : hémipélagites, turbidites, et possibles contourites dans l'Atlantique central occidental

    Directory of Open Access Journals (Sweden)

    Mascle A.

    2006-11-01

    Full Text Available The cenozoic sediments cover of western central Atlantic oceanic floor was cored at about 5 000 m depth, close to the deformation front of the Barbados Accretionary Prism. Good preservation of sedimentary structures and high recovery rate allowed the recognition and study of hemipelagic calcareous or siliceous clays and muds, with or without interbedded airfall volcanic ash beds, and with or without interbedded coarser deposits coming from lateral inputs. The latters are either calcareous fine-grained turbidites coming from local shallower oceanic areas, or terrigenous and calcareous (more hypothetical contourites (reworking turbidites related to bottom currents running along the South-America margin. Fluid-escape veinstructures, related to dewatering process - upward, vertical to almost horizontal advection - were identified, especially in relation with the beginning of offscraping stress in early Miocene incipient décollementhorizon. Twenty-four color print photos of splitted cores are presented; the macroscopic features they show are commented and discussed. La couverture sédimentaire cénozoïque du plancher océanique de l'Atlantique Central occidental a été carottée à environ 5000 m de profondeur, à proximité du front de déformation du prisme d'accrétion de la Barbade. Une bonne préservation des structures sédimentaires et un taux de récupération élevé ont permis la reconnaissance et l'étude d'argilites et shales hémipélagiques, calcaires ou siliceuses, localement intercalées de lits de cendres volcaniques, et auxquelles s'ajoutent des niveaux plus grossiers attribués à des apports latéraux. Ces derniers consistent, soit en turbidites calcareuses à grain fin provenant de hauts-fonds océaniques proches, soit en (plus hypothétiques contourites calcareuses et terrigènes (remaniant des turbidites attribuées à l'activité de courants profonds longeant la marge sud-américaine. Des veinesd'échappement de fluides

  9. Invariant Natural Killer T Cells in Immune Regulation of Blood Cancers: Harnessing Their Potential in Immunotherapies

    Directory of Open Access Journals (Sweden)

    Pui Yeng Lam

    2017-10-01

    Full Text Available Invariant natural killer T (iNKT cells are a unique innate T lymphocyte population that possess cytolytic properties and profound immunoregulatory activities. iNKT cells play an important role in the immune surveillance of blood cancers. They predominantly recognize glycolipid antigens presented on CD1d, but their activation and cytolytic activities are not confined to CD1d expressing cells. iNKT cell stimulation and subsequent production of immunomodulatory cytokines serve to enhance the overall antitumor immune response. Crucially, the activation of iNKT cells in cancer often precedes the activation and priming of other immune effector cells, such as NK cells and T cells, thereby influencing the generation and outcome of the antitumor immune response. Blood cancers can evade or dampen iNKT cell responses by downregulating expression of recognition receptors or by actively suppressing or diverting iNKT cell functions. This review will discuss literature on iNKT cell activity and associated dysregulation in blood cancers as well as highlight some of the strategies designed to harness and enhance iNKT cell functions against blood cancers.

  10. Harnessing scientific literature reports for pharmacovigilance. Prototype software analytical tool development and usability testing.

    Science.gov (United States)

    Sorbello, Alfred; Ripple, Anna; Tonning, Joseph; Munoz, Monica; Hasan, Rashedul; Ly, Thomas; Francis, Henry; Bodenreider, Olivier

    2017-03-22

    We seek to develop a prototype software analytical tool to augment FDA regulatory reviewers' capacity to harness scientific literature reports in PubMed/MEDLINE for pharmacovigilance and adverse drug event (ADE) safety signal detection. We also aim to gather feedback through usability testing to assess design, performance, and user satisfaction with the tool. A prototype, open source, web-based, software analytical tool generated statistical disproportionality data mining signal scores and dynamic visual analytics for ADE safety signal detection and management. We leveraged Medical Subject Heading (MeSH) indexing terms assigned to published citations in PubMed/MEDLINE to generate candidate drug-adverse event pairs for quantitative data mining. Six FDA regulatory reviewers participated in usability testing by employing the tool as part of their ongoing real-life pharmacovigilance activities to provide subjective feedback on its practical impact, added value, and fitness for use. All usability test participants cited the tool's ease of learning, ease of use, and generation of quantitative ADE safety signals, some of which corresponded to known established adverse drug reactions. Potential concerns included the comparability of the tool's automated literature search relative to a manual 'all fields' PubMed search, missing drugs and adverse event terms, interpretation of signal scores, and integration with existing computer-based analytical tools. Usability testing demonstrated that this novel tool can automate the detection of ADE safety signals from published literature reports. Various mitigation strategies are described to foster improvements in design, productivity, and end user satisfaction.

  11. Harnessing Wisdom of the Crowds Dynamics for Time-dependent Reputation and Ranking

    Science.gov (United States)

    Daly, Elizabeth M.

    The "wisdom of the crowds" is a concept used to describe the utility of harnessing group behaviour, where user opinion evolves over time and the opinion of the masses collectively demonstrates wisdom. Web 2.0 is a new medium where users are not just consumers, but are also contributors. By contributing content to the system, users become part of the network and relationships between users and content can be derived. Example applications are collaborative bookmarking networks such as dcl.icio.us and file sharing applications such as You Tube and Fliekr. These networks rely on user contributed content, described and classified using tags. The wealth of user generated content can be hard to navigate and search due to difficulties in comparing documents with similar tags and the application of traditional information retrieval scoring techniques are limited. Evaluating the time evolving interests of users may be used to derive quality of content. In this chapter, we explore a technique to rank documents based on reputation. The reputation is a combination of the number of bookmarkers, the reputation of the bookmarking user and the time dynamics of the document. Additionally, this reputation measure is extended to take into account the time-dependent, term-dependent reputation of a document. Experimental results and analysis are presented on a large collaborative IBM bookmarking network called Dogear.

  12. LncRNAWiki: harnessing community knowledge in collaborative curation of human long non-coding RNAs

    KAUST Repository

    Ma, L.

    2014-11-15

    Long non-coding RNAs (lncRNAs) perform a diversity of functions in numerous important biological processes and are implicated in many human diseases. In this report we present lncRNAWiki (http://lncrna.big.ac.cn), a wiki-based platform that is open-content and publicly editable and aimed at community-based curation and collection of information on human lncRNAs. Current related databases are dependent primarily on curation by experts, making it laborious to annotate the exponentially accumulated information on lncRNAs, which inevitably requires collective efforts in community-based curation of lncRNAs. Unlike existing databases, lncRNAWiki features comprehensive integration of information on human lncRNAs obtained from multiple different resources and allows not only existing lncRNAs to be edited, updated and curated by different users but also the addition of newly identified lncRNAs by any user. It harnesses community collective knowledge in collecting, editing and annotating human lncRNAs and rewards community-curated efforts by providing explicit authorship based on quantified contributions. LncRNAWiki relies on the underling knowledge of scientific community for collective and collaborative curation of human lncRNAs and thus has the potential to serve as an up-to-date and comprehensive knowledgebase for human lncRNAs.

  13. Harnessing Innovative Technologies to Advance Children’s Mental Health: Behavioral Parent Training As an Example

    Science.gov (United States)

    Jones, Deborah J.; Forehand, Rex; Cuellar, Jessica; Kincaid, Carlye; Parent, Justin; Fenton, Nicole; Goodrum, Nada

    2012-01-01

    Disruptive behaviors of childhood are among the most common reasons for referral of children to mental health professionals. Behavioral parent training (BPT) is the most efficacious intervention for these problem behaviors, yet BPT is substantially underutilized beyond university research and clinic settings. With the aim of addressing this research-to-practice gap, this article highlights the considerable, but largely unrealized, potential for technology to overcome the two most pressing challenges hindering the diffusion of BPT: (1). The dearth of BPT training and supervision opportunities for therapists who work with families of children with disruptive behaviors and; (2). The failure to engage and retain families in BPT services when services are available. To this end, this review presents a theoretical framework to guide technological innovations in BPT and highlights examples of how technology is currently being harnessed to overcome these challenges. This review also discusses recommendations for using technology as a delivery vehicle to further advance the field of BPT and the potential implications of technological innovations in BPT for other areas of children’s mental health are discussed. PMID:23313761

  14. Harnessing CRISPR/Cas systems for programmable transcriptional and post-transcriptional regulation

    KAUST Repository

    Mahas, Ahmed

    2017-11-29

    Genome editing has enabled broad advances and novel approaches in studies of gene function and structure; now, emerging methods aim to precisely engineer post-transcriptional processes. Developing precise, efficient molecular tools to alter the transcriptome holds great promise for biotechnology and synthetic biology applications. Different approaches have been employed for targeted degradation of RNA species in eukaryotes, but they lack programmability and versatility, thereby limiting their utility for diverse applications. The CRISPR/Cas9 system has been harnessed for genome editing in many eukaryotic species and, using a catalytically inactive Cas9 variant, the CRISPR/dCas9 system has been repurposed for transcriptional regulation. Recent studies have used other CRISPR/Cas systems for targeted RNA degradation and RNA-based manipulations. For example, Cas13a, a Type VI-A endonuclease, has been identified as an RNA-guided RNA ribonuclease and used for manipulation of RNA. Here, we discuss different modalities for targeted RNA interference with an emphasis on the potential applications of CRISPR/Cas systems as programmable transcriptional regulators for broad uses, including functional biology, biotechnology, and synthetic biology applications.

  15. Harnessing real world data from wearables and self-monitoring devices: feasibility, confounders and ethical considerations

    Directory of Open Access Journals (Sweden)

    Uttam Barick

    2016-07-01

    Full Text Available The increasing usage of smart phones has compelled mobile technology to become a universal part of everyday life. From wearable gadgets to sophisticated implantable medical devices, the advent of mobile technology has completely transformed the healthcare delivery scenario. Self-report measures enabled by mobile technology are increasingly becoming a more time and cost efficient method of assessing real world health outcomes. But, amidst all the optimism, there are concerns also on adopting this technology as regulations and ethical considerations on privacy legislations of end users are unclear. In general, the healthcare industry functions on some stringent regulations and compliances to ensure the safety and protection of patient information. A couple of the most common regulations are Health Insurance Portability Accountability Act (HIPPA and Health Information Technology for Economic and Clinical Health (HITECH. To harness the true potential of mobile technology to empower stakeholders and provide them a common platform which seamlessly integrates healthcare delivery and research, it is imperative that challenges and drawbacks in the sphere are identified and addressed. In this age of information and technology, no stones should be left unturned to ensure that the human race has access to the best healthcare services without an intrusion into his/her confidentiality. This article is an overview of the role of tracking and self-monitoring devices in data collection for real world evidence/observational studies in context to feasibility, confounders and ethical considerations.

  16. Energy-Looping Nanoparticles: Harnessing Excited-State Absorption for Deep-Tissue Imaging.

    Science.gov (United States)

    Levy, Elizabeth S; Tajon, Cheryl A; Bischof, Thomas S; Iafrati, Jillian; Fernandez-Bravo, Angel; Garfield, David J; Chamanzar, Maysamreza; Maharbiz, Michel M; Sohal, Vikaas S; Schuck, P James; Cohen, Bruce E; Chan, Emory M

    2016-09-27

    Near infrared (NIR) microscopy enables noninvasive imaging in tissue, particularly in the NIR-II spectral range (1000-1400 nm) where attenuation due to tissue scattering and absorption is minimized. Lanthanide-doped upconverting nanocrystals are promising deep-tissue imaging probes due to their photostable emission in the visible and NIR, but these materials are not efficiently excited at NIR-II wavelengths due to the dearth of lanthanide ground-state absorption transitions in this window. Here, we develop a class of lanthanide-doped imaging probes that harness an energy-looping mechanism that facilitates excitation at NIR-II wavelengths, such as 1064 nm, that are resonant with excited-state absorption transitions but not ground-state absorption. Using computational methods and combinatorial screening, we have identified Tm(3+)-doped NaYF4 nanoparticles as efficient looping systems that emit at 800 nm under continuous-wave excitation at 1064 nm. Using this benign excitation with standard confocal microscopy, energy-looping nanoparticles (ELNPs) are imaged in cultured mammalian cells and through brain tissue without autofluorescence. The 1 mm imaging depths and 2 μm feature sizes are comparable to those demonstrated by state-of-the-art multiphoton techniques, illustrating that ELNPs are a promising class of NIR probes for high-fidelity visualization in cells and tissue.

  17. Harnessing surface-bound enzymatic reactions to organize microcapsules in solution.

    Science.gov (United States)

    Shklyaev, Oleg E; Shum, Henry; Sen, Ayusman; Balazs, Anna C

    2016-03-01

    By developing new computational models, we examine how enzymatic reactions on an underlying surface can be harnessed to direct the motion and organization of reagent-laden microcapsules in a fluid-filled microchannel. In the presence of appropriate reagents, surface-bound enzymes can act as pumps, which drive large-scale fluid flows. When the reagents diffuse through the capsules' porous shells, they can react with enzymatic sites on the bottom surface. The ensuing reaction generates fluid density variations, which result in fluid flows. These flows carry the suspended microcapsules and drive them to aggregate into "colonies" on and near the enzyme-covered sites. This aggregation continues until the reagent has been depleted and the convection stops. We show that the shape of the assembled colonies can be tailored by patterning the distribution of enzymes on the surface. This fundamental physicochemical mechanism could have played a role in the self-organization of early biological cells (protocells) and can be used to regulate the autonomous motion and targeted delivery of microcarriers in microfluidic devices.

  18. MRI Evaluation of Spinal Length and Vertebral Body Angle During Loading with a Spinal Compression Harness

    Science.gov (United States)

    Campbell, James A.; Hargens, Alan R.; Murthy, G.; Ballard, R. E.; Watenpaugh, D. E.; Hargens, Alan, R.; Sanchez, E.; Yang, C.; Mitsui, I.; Schwandt, D.; hide

    1998-01-01

    Weight bearing by the spinal column during upright posture often plays a role in the common problem of low back pain. Therefore, we developed a non-ferromagnetic spinal compression harness to enable MRI investigations of the spinal column during axial loading. Human subjects were fitted with a Nest and a footplate which were connected by adjustable straps to an analog load cell. MRI scans of human subjects (5 males and 1 female with age range of 27-53 yrs) during loaded and unloaded conditions were accomplished with a 1.5 Tesla GE Signa scanner. Studies of two subjects undergoing sequentially increasing spinal loads revealed significant decreases (r(sup 2) = 0.852) in spinal length between T4 and L5 culminating in a 1.5 to 2% length decrease during loading with 75% body weight. Sagittal vertebral body angles of four subjects placed under a constant 50% body weight load for one hour demonstrated increased lordotic and kyphotic curvatures. In the lumbar spine, the L2 vertebral body experienced the greatest angular change (-3 deg. to -5 deg.) in most subjects while in the thoracic spine, T4 angles increased from the unloaded state by +2 deg. to +9 deg. Overall, our studies demonstrate: 1) a progressive, although surprisingly small, decrease in spinal length with increasing load and 2) relatively large changes in spinal column angulation with 50% body weight.

  19. Helmet Use Amongst Equestrians: Harnessing Social and Attitudinal Factors Revealed in Online Forums

    Directory of Open Access Journals (Sweden)

    Laura Haigh

    2015-07-01

    Full Text Available Equestrian activities pose significant head injury risks to participants. Yet, helmet use is not mandatory in Australia outside of selected competitions. Awareness of technical countermeasures and the dangers of equestrian activities has not resulted in widespread adoption of simple precautionary behaviors like helmet use. Until the use of helmets whilst riding horses is legislated in Australia, there is an urgent need to improve voluntary use. To design effective injury prevention interventions, the factors affecting helmet use must first be understood. To add to current understandings of these factors, we examined the ways horse riders discussed helmet use by analyzing 103 posts on two helmet use related threads from two different Australian equestrian forums. We found evidence of social influence on helmet use behaviors as well as three attitudes that contributed towards stated helmet use that we termed: “I Can Control Risk”, “It Does Not Feel Right” and “Accidents Happen”. Whilst we confirm barriers identified in previous literature, we also identify their ability to support helmet use. This suggests challenging but potentially useful complexity in the relationship between risk perception, protective knowledge, attitudes, decision-making and behavior. Whilst this complexity is largely due to the involvement of interspecies relationships through which safety, risk and trust are distributed; our findings about harnessing the potential of barriers could be extended to other high risk activities.

  20. Deep Unconventional Geothermal Resources: a major opportunity to harness new sources of sustainable energy

    Energy Technology Data Exchange (ETDEWEB)

    Fridleifsson, G.O.; Albertsson, A.; Stefansson, B.; Gunnlaugsson, E.; Adalsteinsson, H.

    2007-07-01

    The Iceland Deep Drilling Project (IDDP) is a long-term program to improve the efficiency and economics of geothermal energy by harnessing Deep Unconventional Geothermal Resources (DUGR). Its aim is to produce electricity from natural supercritical hydrous fluids from drillable depths. Producing supercritical fluids will require drilling wells and sampling fluids and rocks to depths of 3.5 to 5 km, and at temperatures of 450-600{sup o}C. The long-term plan is to drill and test a series of such deep boreholes in Iceland at the Krafla, the Hengill, and the Reykjanes high temperature geothermal systems. Beneath these three developed drill fields temperatures should exceed 550-650{sup o}C, and the occurrence of frequent seismic activity below 5 km, indicates that the rocks are brittle and therefore likely to be permeable. Modeling indicates that if the wellhead enthalpy is to exceed that of conventionally produced geothermal steam, the reservoir temperature must be higher than 450{sup o}C. A deep well producing 0.67 m3/sec steam ({approx}2400 m3/h) from a reservoir with a temperature significantly above 450{sup o}C could yield enough high-enthalpy steam to generate 40-50 MW of electric power. This exceeds by an order of magnitude the power typically obtained from conventional geothermal wells. (auth)

  1. A New 3D Printing Strategy by Harnessing Deformation, Instability, and Fracture of Viscoelastic Inks.

    Science.gov (United States)

    Yuk, Hyunwoo; Zhao, Xuanhe

    2018-02-01

    Direct ink writing (DIW) has demonstrated great potential as a multimaterial multifunctional fabrication method in areas as diverse as electronics, structural materials, tissue engineering, and soft robotics. During DIW, viscoelastic inks are extruded out of a 3D printer's nozzle as printed fibers, which are deposited into patterns when the nozzle moves. Hence, the resolution of printed fibers is commonly limited by the nozzle's diameter, and the printed pattern is limited by the motion paths. These limits have severely hampered innovations and applications of DIW 3D printing. Here, a new strategy to exceed the limits of DIW 3D printing by harnessing deformation, instability, and fracture of viscoelastic inks is reported. It is shown that a single nozzle can print fibers with resolution much finer than the nozzle diameter by stretching the extruded ink, and print various thickened or curved patterns with straight nozzle motions by accumulating the ink. A quantitative phase diagram is constructed to rationally select parameters for the new strategy. Further, applications including structures with tunable stiffening, 3D structures with gradient and programmable swelling properties, all printed with a single nozzle are demonstrated. The current work demonstrates that the mechanics of inks plays a critical role in developing 3D printing technology. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Salinity stress induced lipid synthesis to harness biodiesel during dual mode cultivation of mixotrophic microalgae.

    Science.gov (United States)

    Venkata Mohan, S; Devi, M Prathima

    2014-08-01

    Influence of salinity as a stress factor to harness biodiesel was assessed during dual mode cultivation of microalgae by integrating biomass growth phase (BGP) and salinity induced lipid induction phase (LIP). BGP was evaluated in mixotrophic mode employing nutrients (NPK) and carbon (glucose) source while LIP was operated under stress environment with varying salt concentrations (0, 0.5, 1 and 2gNaCl/l). Salinity stress triggered both biomass growth and lipid synthesis in microalgae significantly. BGP showed higher increments in biomass growth (2.55g/l) while LIP showed higher lipid productivity (1gNaCl/l; total/neutral lipid, 23.4/9.2%) than BGP (total/neutral lipid, 15.2/6%). Lower concentrations of salinity showed positive influence on the process while higher concentrations showed marked inhibition. Salinity stress also facilitated in maintaining saturated fatty acid methyl esters in higher amounts which associates with the improved fuel properties. Efficient wastewater treatment was observed during BGP operation indicating the assimilation of carbon/nutrients by microalgae. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Harnessing structural darkness in the visible and infrared wavelengths for a new source of light.

    Science.gov (United States)

    Huang, Jianfeng; Liu, Changxu; Zhu, Yihan; Masala, Silvia; Alarousu, Erkki; Han, Yu; Fratalocchi, Andrea

    2016-01-01

    Engineering broadband light absorbers is crucial to many applications, including energy-harvesting devices and optical interconnects. The performances of an ideal absorber are that of a black body, a dark material that absorbs radiation at all angles and polarizations. Despite advances in micrometre-thick films, the absorbers available to date are still far from an ideal black body. Here, we describe a disordered nanostructured material that shows an almost ideal black-body absorption of 98-99% between 400 and 1,400 nm that is insensitive to the angle and polarization of the incident light. The material comprises nanoparticles composed of a nanorod with a nanosphere of 30 nm diameter attached. When diluted into liquids, a small concentration of nanoparticles absorbs on average 26% more than carbon nanotubes, the darkest material available to date. By pumping a dye optical amplifier with nanosecond pulses of ∼100 mW power, we harness the structural darkness of the material and create a new type of light source, which generates monochromatic emission (∼5 nm wide) without the need for any resonance. This is achieved through the dynamics of light condensation in which all absorbed electromagnetic energy spontaneously generates single-colour energy pulses.

  4. Building mechanical Greenberger-Horne-Zeilinger and cluster states by harnessing optomechanical quantum steerable correlations

    Science.gov (United States)

    Tan, Huatang; Wei, Yanghua; Li, Gaoxiang

    2017-11-01

    Greenberger-Horne-Zeilinger (GHZ) and cluster states are two typical kinds of multipartite entangled states and can respectively be used for realizing quantum networks and one-way computation. We propose a feasible scheme for generating Gaussian GHZ and cluster states of multiple mechanical oscillators by pulsed cavity optomechanics. In our scheme, each optomechanical cavity is driven by a blue-detuned pulse to establish quantum steerable correlations between the cavity output field and the mechanical oscillator, and the cavity outputs are combined at a beam-splitter array with given transmissivity and reflectivity for each beam splitter. We show that by harnessing the light-mechanical steerable correlations, the mechanical GHZ and cluster states can be realized via homodyne detection on the amplitude and phase quadratures of the output fields from the beam-splitter array. These achieved mechanical entangled states can be viewed as the output states of an effective mechanical beam-splitter array with the mechanical inputs prepared in squeezed states with the light-mechanical steering. The effects of detection efficiency and thermal noise on the achieved mechanical states are investigated. The present scheme does not require externally injected squeezing and it can also be applicable to other systems such as light-atomic-ensemble interface, apart from optomechanical systems.

  5. Harnessing rogue wave for supercontinuum generation in cascaded photonic crystal fiber.

    Science.gov (United States)

    Zhao, Saili; Yang, Hua; Zhao, Chujun; Xiao, Yuzhe

    2017-04-03

    Based on induced modulation instability, we present a numerical study on harnessing rogue wave for supercontinuum generation in cascaded photonic crystal fibers. By selecting optimum modulation frequency, we achieve supercontinuum with a great improvement on spectrum stability when long-pulse is used as the pump. In this case, rogue wave can be obtained in the first segmented photonic crystal fiber with one zero dispersion wavelength in a controllable manner. Numerical simulations show that spectral range and flatness can be regulated in an extensive range by cascading a photonic crystal fiber with two zero dispersion wavelengths. Some novel phenomena are observed in the second segmented photonic crystal fiber. When the second zero dispersion wavelength is close to the first one, rogue wave is directly translated into dispersion waves, which is conducive to the generation of smoother supercontinuum. When the second zero dispersion wavelength is far away from the first one, rogue wave is translated into the form of fundamental soliton steadily propagating in the vicinity of the second zero dispersion wavelength. Meanwhile, the corresponding red-shifted dispersion wave is generated when the phase matching condition is met, which is beneficial to the generation of wider supercontinuum. The results presented in this work provide a better application of optical rogue wave to generate flat and broadband supercontinuum in cascaded photonic crystal fibers.

  6. Harnessing the immune system through programmed death-1 blockade in the management of Hodgkin lymphoma

    Directory of Open Access Journals (Sweden)

    Oncale MB

    2017-02-01

    Full Text Available Melody B Oncale, Hossein Maymani, Loretta J Nastoupil Department of Lymphoma and Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Abstract: Immunotherapy is a rapidly evolving therapeutic option in the treatment of lymphoma. Neoplastic cells evade immune recognition through the programmed death (PD-1/PD-ligand immune checkpoint pathway. Several novel agents have been developed to restore the immune system’s ability to recognize and destroy cancer cells. Nivolumab and pembrolizumab are two anti-PD-1 antibodies that have demonstrated success in the treatment of refractory Hodgkin lymphoma. Harnessing the immune system’s ability to target neoplastic cells, ideally without the use of cytotoxic chemotherapeutic agents, is one way in which these novel agents are changing the therapeutic landscape in the treatment of lymphomas. Here, we review the emerging data regarding checkpoint inhibitors in the management of Hodgkin lymphoma, the unique adverse effects encountered with the use of these agents, and a practical approach to the management of these adverse effects. Additionally, we discuss upcoming trials that will further assess the promising future developments of checkpoint inhibition in the treatment of not only Hodgkin lymphoma but also other B cell lymphomas and myeloma. These agents offer immense promise of a future where many lymphomas can be treated without the toxic effects of chemotherapeutic agents. Keywords: Hodgkin lymphoma, programmed death-1, nivolumab, pembrolizumab, lymphoma

  7. Harnessing the opportunities of austerity: a detailed mapping of the Greek transportation sector

    Directory of Open Access Journals (Sweden)

    Iraklis Stamos

    2016-12-01

    Full Text Available Since 2009, shortly after the global economic crisis of 2008, Greece has entered into a deep recession phase. The multifaceted presence of austerity is experienced in an increasing number of sectors of the country. The Greek transportation sector is not immune to this state of affairs. The ongoing crisis had a significant impact on its economic (investment, employment, exports-imports turnover as well as its operational (transportation intensity, throughput, performance aspects and capabilities. In this paper, a detailed mapping of these impacts is laid out, correlating transport-related characteristics, trends and estimations with the respective economic ones. Specifically, the paper presents analyses of the Greek passenger and freight transportation, following a data-driven approach over several areas. Findings show a substantial decrease of activities overall. Paradoxically, however, austerity can also be said to offer opportunities, such as the development of innovative, cost-effective and outward-looking business schemes, for handling transportation-related issues. In the face of these opportunities, authorities and stakeholders have recently turned their attention to ways of harnessing them as they may arise. The paper conducts a detailed analysis of these efforts to discover prospects for development in the midst of austerity, and highlights the steps currently being taken in that direction.

  8. Harnessing the Power of Reputation: Strengths and Limits for Promoting Cooperative Behaviors

    Directory of Open Access Journals (Sweden)

    Pat Barclay

    2012-12-01

    Full Text Available Evolutionary approaches have done much to identify the pressures that select for cooperative sentiment. This helps us understand when and why cooperation will arise, and applied research shows how these pressures can be harnessed to promote various types of cooperation. In particular, recent evidence shows how opportunities to acquire a good reputation can promote cooperation in laboratory and applied settings. Cooperation can be promoted by tapping into forces like indirect reciprocity, costly signaling, and competitive altruism. When individuals help others, they receive reputational benefits (or avoid reputational costs, and this gives people an incentive to help. Such findings can be applied to promote many kinds of helping and cooperation, including charitable donations, tax compliance, sustainable and pro-environmental behaviors, risky heroism, and more. Despite the potential advantages of using reputation to promote positive behaviors, there are several risks and limits. Under some circumstances, opportunities for reputation will be ineffective or promote harmful behaviors. By better understanding the dynamics of reputation and the circumstances under which cooperation can evolve, we can better design social systems to increase the rate of cooperation and reduce conflict.

  9. Harnessing the Flexibility of Thermostatic Loads in Microgrids with Solar Power Generation

    Directory of Open Access Journals (Sweden)

    Rosa Morales González

    2016-07-01

    Full Text Available This paper presents a demand response (DR framework that intertwines thermodynamic building models with a genetic algorithm (GA-based optimization method. The framework optimizes heating/cooling schedules of end-users inside a business park microgrid with local distributed generation from renewable energy sources (DG-RES based on two separate objectives: net load minimization and electricity cost minimization. DG-RES is treated as a curtailable resource in anticipation of future scenarios where the infeed of DG-RES to the regional distribution network could be limited. We test the DR framework with a case study of a refrigerated warehouse and an office building located in a business park with local PV generation. Results show the technical potential of the DR framework in harnessing the flexibility of the thermal masses from end-user sites in order to: (1 reduce the energy exchange at the point of connection; (2 reduce the cost of electricity for the microgrid end-users; and (3 increase the local utilization of DG-RES in cases where DG-RES exports to the grid are restricted. The results of this work can aid end-users and distribution network operators to reduce energy costs and energy consumption.

  10. Harnessing coherence of area decomposition and semantic shared spaces for task allocation in a robotic fleet

    Directory of Open Access Journals (Sweden)

    Domagoj Drenjanac

    2014-08-01

    Full Text Available Task allocation is a fundamental problem in multi-robot systems where heterogeneous robots cooperate to perform a complex mission. A general requirement in a task allocation algorithm is to find an optimal set of robots to execute a certain task. This paper presents the work that harnesses an area decomposition algorithm, and a space-based middleware to facilitate task allocation process in unstructured and dynamic environments. To reduce spatial interference between robots, area decomposition algorithm divides a working area into cells which are then dynamically assigned to robots. In addition, coordination and collaboration among distributed robots are realized through a space-based middleware. For this purpose, the space-based middleware is extended with a semantic model of robot capabilities to improve task selection in terms of flexibility, scalability, and reduced communication overhead during task allocation. In this way a framework which exploits the synergy of area decomposition and semantically enriched space-based approach is created. We conducted performance tests in a specific precision agriculture use case focusing on the utilization of a robotic fleet for weed control introduced in the European Project RHEA – Robot Fleets for Highly Effective Agriculture and Forestry Management.

  11. Harnessing intrinsic localized modes to identify impurities in nonlinear periodic systems

    Science.gov (United States)

    Thota, M.; Harne, R. L.; Wang, K. W.

    2015-02-01

    Intrinsic localized modes (ILMs) are concentrations of vibrational energy in periodic systems/lattices due to the combined influences of nonlinearity and discreteness. Moreover, ILMs can move within the system and may strongly interact with an impurity, such as a stiffness change, mass variation, etc. Numerous scientific fields have uncovered examples and evidence of ILMs, motivating a multidisciplinary pursuit to rigorously understand the underlying principles. In spite of the diverse technical studies, a characterization of ILM interaction behaviors with multiple impurities in dissipative lattices remains outstanding. The insights on such behaviors may be broadly useful when dynamic measurements are the only accessible features of the periodic system. For instance, one may guide an ILM within the lattice using a deliberately applied and steered impurity and harness the observed interaction behaviors with a second, static (immovable) impurity/defect to identify how the underlying lattice is different at the second, defected site, whether or not one knew the position of the defect a priori. In this spirit, this research studies, analyzes, and characterizes the interaction types amongst an ILM and multiple impurities, and devises a method to identify a static defect impurity using quantitatively and qualitatively distinct interaction phenomena. The method is found to be robust to moderate levels of lattice stiffness heterogeneity and is applicable to monitor various property changes that represent impurities. Finally, experimental studies verify that ILMs interact with multiple impurities in unique ways such that defect features may be effectively identified.

  12. A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells

    Science.gov (United States)

    Erb, Marcella L; Kraemer, James A; Coker, Joanna K C; Chaikeeratisak, Vorrapon; Nonejuie, Poochit; Agard, David A; Pogliano, Joe

    2014-01-01

    Dynamic instability, polarity, and spatiotemporal organization are hallmarks of the microtubule cytoskeleton that allow formation of complex structures such as the eukaryotic spindle. No similar structure has been identified in prokaryotes. The bacteriophage-encoded tubulin PhuZ is required to position DNA at mid-cell, without which infectivity is compromised. Here, we show that PhuZ filaments, like microtubules, stochastically switch from growing in a distinctly polar manner to catastrophic depolymerization (dynamic instability) both in vitro and in vivo. One end of each PhuZ filament is stably anchored near the cell pole to form a spindle-like array that orients the growing ends toward the phage nucleoid so as to position it near mid-cell. Our results demonstrate how a bacteriophage can harness the properties of a tubulin-like cytoskeleton for efficient propagation. This represents the first identification of a prokaryotic tubulin with the dynamic instability of microtubules and the ability to form a simplified bipolar spindle. DOI: http://dx.doi.org/10.7554/eLife.03197.001 PMID:25429514

  13. Harnessing Wind Power in Moving Reference Frames with Application to Vehicles

    Science.gov (United States)

    Goushcha, Oleg; Felicissimo, Robert; Danesh-Yazdi, Amir; Andreopoulos, Yiannis

    2017-11-01

    The extraction of wind power from unique configurations embedded in moving vehicles by using micro-turbine devices has been investigated. In such moving environments, the specific power of the air motion is much greater and less intermittent than in stationary wind turbines anchored to the ground in open atmospheric conditions. In a translational frame of reference, the rate of work done by the drag force acting on the wind harnessing device due the relative motion of air should be taken into account in the overall performance evaluation through an energy balance. A device with a venting tube has been tested that connects a high-pressure stagnating flow region in the front of the vehicle with a low-pressure region at its rear. Our analysis identified two key areas to focus on for potentially significant rewards: (1) Vehicles with high energy conversion efficiency which require a high mass flow rate through the venting duct, and (2) low efficiency vehicles with wakes, which will be globally affected by the introduction of the venting duct device in a manner that reduces their drag so that there is a net gain in power generation.

  14. Harnessing structural darkness in the visible and infrared wavelengths for a new source of light

    KAUST Repository

    Huang, Jianfeng

    2015-10-19

    Engineering broadband light absorbers is crucial to many applications, including energy-harvesting devices and optical interconnects. The performances of an ideal absorber are that of a black body, a dark material that absorbs radiation at all angles and polarizations. Despite advances in micrometre-thick films, the absorbers available to date are still far from an ideal black body. Here, we describe a disordered nanostructured material that shows an almost ideal black-body absorption of 98-99% between 400 and 1,400 nm that is insensitive to the angle and polarization of the incident light. The material comprises nanoparticles composed of a nanorod with a nanosphere of 30 nm diameter attached. When diluted into liquids, a small concentration of nanoparticles absorbs on average 26% more than carbon nanotubes, the darkest material available to date. By pumping a dye optical amplifier with nanosecond pulses of 100 mW power, we harness the structural darkness of the material and create a new type of light source, which generates monochromatic emission (5 nm wide) without the need for any resonance. This is achieved through the dynamics of light condensation in which all absorbed electromagnetic energy spontaneously generates single-colour energy pulses. © 2016 Macmillan Publishers Limited. All rights reserved.

  15. Harnessing biomaterials to engineer the lymph node microenvironment for immunity or tolerance.

    Science.gov (United States)

    Andorko, James I; Hess, Krystina L; Jewell, Christopher M

    2015-03-01

    Nanoparticles, microparticles, and other biomaterials are advantageous in vaccination because these materials provide opportunities to modulate specific characteristics of immune responses. This idea of "tuning" immune responses has recently been used to combat infectious diseases and cancer, and to induce tolerance during organ transplants or autoimmune disease. Lymph nodes and other secondary lymphoid organs such as the spleen play crucial roles in determining if and how these responses develop following vaccination or immunotherapy. Thus, by manipulating the local microenvironments within these immunological command centers, the nature of systemic immune response can be controlled. This review provides recent examples that harness the interactions between biomaterials and lymph nodes or other secondary lymphoid organs to generate immunity or promote tolerance. These strategies draw on mechanical properties, surface chemistry, stability, and targeting to alter the interactions of cells, signals, and vaccine components in lymph nodes. While there are still many unanswered questions surrounding how best to design biomaterial-based vaccines to promote specific structures or functions in lymph nodes, features such as controlled release and targeting will help pave the way for the next generation of vaccines and immunotherapies that generate immune responses tuned for specific applications.

  16. Harnessing innovative technologies to advance children's mental health: behavioral parent training as an example.

    Science.gov (United States)

    Jones, Deborah J; Forehand, Rex; Cuellar, Jessica; Kincaid, Carlye; Parent, Justin; Fenton, Nicole; Goodrum, Nada

    2013-03-01

    Disruptive behaviors of childhood are among the most common reasons for referral of children to mental health professionals. Behavioral parent training (BPT) is the most efficacious intervention for these problem behaviors, yet BPT is substantially underutilized beyond university research and clinic settings. With the aim of addressing this research-to-practice gap, this article highlights the considerable, but largely unrealized, potential for technology to overcome the two most pressing challenges hindering the diffusion of BPT: (1). The dearth of BPT training and supervision opportunities for therapists who work with families of children with disruptive behaviors; and (2). The failure to engage and retain families in BPT services when services are available. To this end, this review presents a theoretical framework to guide technological innovations in BPT and highlights examples of how technology is currently being harnessed to overcome these challenges. This review also discusses recommendations for using technology as a delivery vehicle to further advance the field of BPT and the potential implications of technological innovations in BPT for other areas of children's mental health are discussed. Copyright © 2012 Elsevier Ltd. All rights reserved.

  17. Humeral remodeling and soft tissue injury of the wings caused by backpack harnesses for radio transmitters in New Zealand Takahē (Porphyrio hochstetteri).

    Science.gov (United States)

    Michael, Sarah; Gartrell, Brett; Hunter, Stuart

    2013-07-01

    Backpack harnesses are commonly used to attach radio and satellite transmitters to a wide range of bird species for research and conservation management. They are an integral part of the conservation management of the New Zealand Takahē (Porphyrio hochstetteri), an endangered flightless rail. Radio transmitters mounted on backpack harnesses enable the birds to be tracked in their remaining native range of remote, mountainous Fiordland, New Zealand. We evaluated 26 Takahē retrospectively at necropsy by gross examination, radiography, and computed tomography to assess damage from the backpack harness. Ten birds that had never worn a harness had no evidence of wing injury. Of the 16 birds that had worn a harness, 10 (63%) had superficial soft tissue injury to skin or patagium or more severe injury, such as remodeling of the distal humerus at the harness cord-wing interface, or pathologic fractures. Such injuries are hypothesized to be associated with discomfort, increased risk of infection or fracture, and therefore reduced fitness. These findings have implications for all avian species deployed with backpack harnesses.

  18. Skal ophavsretten afskaffes? - Ophavsretten har det ikke så let i de her år

    Directory of Open Access Journals (Sweden)

    Morten Rosenmeier

    2010-12-01

    Full Text Available Ophavsretten har det ikke så let i de her år. Den stammer fra en tid, hvor verden var analog. Bøger var noget, man købte hos boghandleren. Musikken købte man i FONA. Og film så man i biografen. Men nu er verden digital. Kopierne er ikke til at skelne fra originalerne. Er tiden løbet fra alt det ophavsret?

  19. Har de vokst det av seg? Generasjons- og livsfaseforklaringer på ungdoms holdninger til frivillig organisering

    Directory of Open Access Journals (Sweden)

    Dag Wollebæk

    2014-10-01

    Full Text Available I denne artikkelen analyserer vi holdninger til frivillighet og organisasjonsdeltakelse blant ulike aldersgrupper. Spørsmålet vi reiser, er om forskjeller i holdninger mellom aldersgrupper primært er livsfase- eller generasjonsbetingede. Til å besvare disse spørsmålene benytter vi to befolkningsundersøkelser med frivillighet som tema. Den første ble gjennomført i 1998, og den andre ble gjennomført i 2009. Mange av spørsmålene er like i de to undersøkelsene. Selv om vi ikke kan følge enkeltpersoner over disse elleve årene, har vi undersøkt om dagens 27–35-åringer svarer det samme som 16–24-åringene gjorde i 1998. Vi har i tillegg undersøkt betydningen av utskiftning av alderskohorter i befolkningen. Ungdoms svar på holdningsspørsmålene i 1998-undersøkelsen varslet om et nytt, mer individualisert organisasjonssamfunn. I dag kan vi slå fast at det er stor grad av stabilitet i holdningene til frivillig organisering internt i kohortene. Våre analyser viser med andre ord at generasjonsperspektivet er klart viktigere enn livsfaseperspektivet for å forstå holdningsforskjeller mellom aldersgruppene. Hvis det er rett, slik blant annet forskningen om valgdeltakelse har vist, at deltakelsesmønstrene setter seg i ung alder, er det grunn til å anta at endringene vi har observert over den siste tiårsperioden, kommer til å tilta i styrke og betydning i årene framover.

  20. Harnessing non-covalent interactions to exert control over regioselectivity and site-selectivity in catalytic reactions

    OpenAIRE

    Davis, Holly J; Phipps, Robert J.

    2016-01-01

    Asymmetric catalysis has been revolutionised by the realisation that attractive non-covalent interactions such as hydrogen bonds and ion pairs can act as powerful controllers of enantioselectivity when incorporated into appropriate small molecule chiral scaffolds. Given these tremendous advances it is surprising that there are still a relatively limited number of examples of non-covalent interactions being harnessed for control of regioselectivity or site-selectivity in catalysis, two other f...

  1. Impact of ionic and nanoparticle speciation states of silver on light harnessing photosynthetic events in Spirodela polyrhiza.

    Science.gov (United States)

    Shabnam, Nisha; Sharmila, P; Pardha-Saradhi, P

    2017-01-02

    Owing to wide range of applications, nanotechnology is growing expeditiously. Likely negative impact of nanoparticles (NPs), which are inevitably released into our surroundings, on living organisms is of growing concern. Findings presented here are outcome of investigations carried out to evaluate the impact of ionic and NP speciation states of silver on light harnessing photosynthetic events in Spirodela polyrhiza fronds. Fronds exposed to ionic speciation state showed significant decline in PS (photosystem) II efficiency (Fv/Fm; variable fluorescence/maximal fluorescence), while those exposed to silver nanoparticles (Ag-NPs) showed marginal decline. Accordingly, decline in amplitude of Chl a fluorescence transients was sharper in fronds treated with Ag + than those treated with Ag-NPs. Of the various phases Chl a fluorescence transient, J-I phase [which reflects reduction of plastoquinone (PQ) pool] was most sensitive to both Ag + and Ag-NPs. Phenomenological yield models, built using Biolyzer software, revealed that fronds exposed to Ag + possessed significantly lower potential to trap and harness absorbed light energy for photochemical reactions than those exposed to Ag-NPs. Accordingly, dissipation of absorbed light energy as heat was significantly higher in fronds exposed to Ag + than those exposed to Ag-NPs. These findings revealed that NP speciation state of silver is significantly less toxic to light harnessing photosynthetic machinery of S. polyrhiza, compared to ionic speciation state.

  2. Assessment of Petrophysical Surface Data of the Harşit Granitoid in Trabzon, in Northeastern Turkey

    Science.gov (United States)

    Aydin, Ali; Ceryan, Şener

    2012-01-01

    The Harşit granitoid in northeastern Turkey, comprises four separate granite units that are apparently unfoliated. The Harşit granitoid was investigated here by using microstructural, petrofabric and anisotropy of magnetic susceptibility (AMS) data. The structural data of the granitoid were found to be highly compatible with the zonation recognized from AMS measurements. The orientation of magnetic fabrics within the granite units indicates that tectonic deformation might have occurred coevally with the magmatic emplacement of the intrusion. When we evaluated the manners on the scale of the pluton that the disruption took place in the form of uplifting, probably related to a rapid migration of the volcanic front and the documented change from deep sea sedimentation predominant until late Cretaceous to shallower environments during the Paleocene. The possible tectonic control of fault systems on the ascent and emplacement of the granitic magma in the study area, however, cannot be completely ruled out because the Harşit granitoid is situated at or very near the NAF systems in northern Anatolia. In any case, the intrusion is clearly discordant to the regional deformational features formed during the collisional events between the Eurasia and Anatolia plates in northern Turkey.

  3. The Ismailis’ « War » against Qat in Harâz

    Directory of Open Access Journals (Sweden)

    Peer Gatter

    2007-03-01

    Full Text Available La « guerre » des ismaeiliens contre le qat dans le Haraz.Entre mobilisation communautaire et contraintes politico-économiquesEn 1999, la communauté ismaélienne des Bohra, du massif du .Harâz a lancé une campagne pour remplacer la culture du qat par d’autres activités économiques. Fortement motivée sur le plan religieux, cette campagne visait aussi à la suppression de la consommation du qat. Plus de 200 000 arbustes de qat ont étés arrachés, auxquels on a substitué des caféiers et des manguiers. Les moyens pour générer les revenus alternatifs incluaient aussi l’élevage, l’apiculture, la planification du développement d’artisanat, à quoi s’ajoutaient des projets d’irrigation, des programmes éducatifs et des prêts sans intérêt pour les investissements dans d’autres secteurs économiques. Bien que cette campagne ait été entravée dès le début par une sécheresse sévère ainsi que par l’absence d’aide gouvernementale, il a abouti d’une part à une réduction réelle de la culture et de la consommation du qat, et à la diversification importante de l’activité économique des fermiers. Mais le projet a aussi entrainé une migration accrue de la campagne vers les villes et l’abandon de nombreuses terres cultivées. Cependant, malgré ces limites, ce projet, unique au Yémen par son haut niveau de la mobilisation sociale, apporte des leçons précieuses concernant les contraintes politiques et économiques qui pèsent sur toute tentative de développer une agriculture sans qat dans les montagnes du Yémen.In 1999, the Ismailî   Bohra Community in Yemen’s Harâz mountains launched a drug substitution programme in order to replace the cultivation of qat with other economic and social activities. Motivated by religious concern, this campaign aimed at suppressing the consumption of qat. Over 200,000 qat trees were uprooted and coffee and mango trees planted instead. Alternative means of income

  4. Harnessing diversity towards the reconstructing of large scale gene regulatory networks.

    Directory of Open Access Journals (Sweden)

    Takeshi Hase

    Full Text Available Elucidating gene regulatory network (GRN from large scale experimental data remains a central challenge in systems biology. Recently, numerous techniques, particularly consensus driven approaches combining different algorithms, have become a potentially promising strategy to infer accurate GRNs. Here, we develop a novel consensus inference algorithm, TopkNet that can integrate multiple algorithms to infer GRNs. Comprehensive performance benchmarking on a cloud computing framework demonstrated that (i a simple strategy to combine many algorithms does not always lead to performance improvement compared to the cost of consensus and (ii TopkNet integrating only high-performance algorithms provide significant performance improvement compared to the best individual algorithms and community prediction. These results suggest that a priori determination of high-performance algorithms is a key to reconstruct an unknown regulatory network. Similarity among gene-expression datasets can be useful to determine potential optimal algorithms for reconstruction of unknown regulatory networks, i.e., if expression-data associated with known regulatory network is similar to that with unknown regulatory network, optimal algorithms determined for the known regulatory network can be repurposed to infer the unknown regulatory network. Based on this observation, we developed a quantitative measure of similarity among gene-expression datasets and demonstrated that, if similarity between the two expression datasets is high, TopkNet integrating algorithms that are optimal for known dataset perform well on the unknown dataset. The consensus framework, TopkNet, together with the similarity measure proposed in this study provides a powerful strategy towards harnessing the wisdom of the crowds in reconstruction of unknown regulatory networks.

  5. Harnessing Sun’s Energy with Quantum Dots Based Next Generation Solar Cell

    Science.gov (United States)

    Halim, Mohammad A.

    2012-01-01

    Our energy consumption relies heavily on the three components of fossil fuels (oil, natural gas and coal) and nearly 83% of our current energy is consumed from those sources. The use of fossil fuels, however, has been viewed as a major environmental threat because of their substantial contribution to greenhouse gases which are responsible for increasing the global average temperature. Last four decades, scientists have been searching for alternative sources of energy which need to be environmentally clean, efficient, cost-effective, renewable, and sustainable. One of the promising sustainable sources of energy can be achieved by harnessing sun energy through silicon wafer, organic polymer, inorganic dye, and quantum dots based solar cells. Among them, quantum dots have an exceptional property in that they can excite multiple electrons using only one photon. These dots can easily be synthesized, processed in solution, and incorporated into solar cell application. Interestingly, the quantum dots solar cells can exceed the Shockley-Queisser limit; however, it is a great challenge for other solar cell materials to exceed the limit. Theoretically, the quantum dots solar cell can boost the power conversion efficiency up to 66% and even higher to 80%. Moreover, in changing the size of the quantum dots one can utilize the Sun’s broad spectrum of visible and infrared ranges. This review briefly overviews the present performance of different materials-based solar cells including silicon wafer, dye-sensitized, and organic solar cells. In addition, recent advances of the quantum dots based solar cells which utilize cadmium sulfide/selenide, lead sulfide/selenide, and new carbon dots as light harvesting materials has been reviewed. A future outlook is sketched as to how one could improve the efficiency up to 10% from the current highest efficiency of 6.6%. PMID:28348320

  6. The HARNESS Workbench: Unified and Adaptive Access to Diverse HPC Platforms

    Energy Technology Data Exchange (ETDEWEB)

    Sunderam, Vaidy S.

    2012-03-20

    The primary goal of the Harness WorkBench (HWB) project is to investigate innovative software environments that will help enhance the overall productivity of applications science on diverse HPC platforms. Two complementary frameworks were designed: one, a virtualized command toolkit for application building, deployment, and execution, that provides a common view across diverse HPC systems, in particular the DOE leadership computing platforms (Cray, IBM, SGI, and clusters); and two, a unified runtime environment that consolidates access to runtime services via an adaptive framework for execution-time and post processing activities. A prototype of the first was developed based on the concept of a 'system-call virtual machine' (SCVM), to enhance portability of the HPC application deployment process across heterogeneous high-end machines. The SCVM approach to portable builds is based on the insertion of toolkit-interpretable directives into original application build scripts. Modifications resulting from these directives preserve the semantics of the original build instruction flow. The execution of the build script is controlled by our toolkit that intercepts build script commands in a manner transparent to the end-user. We have applied this approach to a scientific production code (Gamess-US) on the Cray-XT5 machine. The second facet, termed Unibus, aims to facilitate provisioning and aggregation of multifaceted resources from resource providers and end-users perspectives. To achieve that, Unibus proposes a Capability Model and mediators (resource drivers) to virtualize access to diverse resources, and soft and successive conditioning to enable automatic and user-transparent resource provisioning. A proof of concept implementation has demonstrated the viability of this approach on high end machines, grid systems and computing clouds.

  7. Harnessing Sun's Energy with Quantum Dots Based Next Generation Solar Cell.

    Science.gov (United States)

    Halim, Mohammad A

    2012-12-27

    Our energy consumption relies heavily on the three components of fossil fuels (oil, natural gas and coal) and nearly 83% of our current energy is consumed from those sources. The use of fossil fuels, however, has been viewed as a major environmental threat because of their substantial contribution to greenhouse gases which are responsible for increasing the global average temperature. Last four decades, scientists have been searching for alternative sources of energy which need to be environmentally clean, efficient, cost-effective, renewable, and sustainable. One of the promising sustainable sources of energy can be achieved by harnessing sun energy through silicon wafer, organic polymer, inorganic dye, and quantum dots based solar cells. Among them, quantum dots have an exceptional property in that they can excite multiple electrons using only one photon. These dots can easily be synthesized, processed in solution, and incorporated into solar cell application. Interestingly, the quantum dots solar cells can exceed the Shockley-Queisser limit; however, it is a great challenge for other solar cell materials to exceed the limit. Theoretically, the quantum dots solar cell can boost the power conversion efficiency up to 66% and even higher to 80%. Moreover, in changing the size of the quantum dots one can utilize the Sun's broad spectrum of visible and infrared ranges. This review briefly overviews the present performance of different materials-based solar cells including silicon wafer, dye-sensitized, and organic solar cells. In addition, recent advances of the quantum dots based solar cells which utilize cadmium sulfide/selenide, lead sulfide/selenide, and new carbon dots as light harvesting materials has been reviewed. A future outlook is sketched as to how one could improve the efficiency up to 10% from the current highest efficiency of 6.6%.

  8. Harnessing diversity towards the reconstructing of large scale gene regulatory networks.

    Science.gov (United States)

    Hase, Takeshi; Ghosh, Samik; Yamanaka, Ryota; Kitano, Hiroaki

    2013-01-01

    Elucidating gene regulatory network (GRN) from large scale experimental data remains a central challenge in systems biology. Recently, numerous techniques, particularly consensus driven approaches combining different algorithms, have become a potentially promising strategy to infer accurate GRNs. Here, we develop a novel consensus inference algorithm, TopkNet that can integrate multiple algorithms to infer GRNs. Comprehensive performance benchmarking on a cloud computing framework demonstrated that (i) a simple strategy to combine many algorithms does not always lead to performance improvement compared to the cost of consensus and (ii) TopkNet integrating only high-performance algorithms provide significant performance improvement compared to the best individual algorithms and community prediction. These results suggest that a priori determination of high-performance algorithms is a key to reconstruct an unknown regulatory network. Similarity among gene-expression datasets can be useful to determine potential optimal algorithms for reconstruction of unknown regulatory networks, i.e., if expression-data associated with known regulatory network is similar to that with unknown regulatory network, optimal algorithms determined for the known regulatory network can be repurposed to infer the unknown regulatory network. Based on this observation, we developed a quantitative measure of similarity among gene-expression datasets and demonstrated that, if similarity between the two expression datasets is high, TopkNet integrating algorithms that are optimal for known dataset perform well on the unknown dataset. The consensus framework, TopkNet, together with the similarity measure proposed in this study provides a powerful strategy towards harnessing the wisdom of the crowds in reconstruction of unknown regulatory networks.

  9. Harnessing Sun’s Energy with Quantum Dots Based Next Generation Solar Cell

    Directory of Open Access Journals (Sweden)

    Mohammad A. Halim

    2012-12-01

    Full Text Available Our energy consumption relies heavily on the three components of fossil fuels (oil, natural gas and coal and nearly 83% of our current energy is consumed from those sources. The use of fossil fuels, however, has been viewed as a major environmental threat because of their substantial contribution to greenhouse gases which are responsible for increasing the global average temperature. Last four decades, scientists have been searching for alternative sources of energy which need to be environmentally clean, efficient, cost-effective, renewable, and sustainable. One of the promising sustainable sources of energy can be achieved by harnessing sun energy through silicon wafer, organic polymer, inorganic dye, and quantum dots based solar cells. Among them, quantum dots have an exceptional property in that they can excite multiple electrons using only one photon. These dots can easily be synthesized, processed in solution, and incorporated into solar cell application. Interestingly, the quantum dots solar cells can exceed the Shockley-Queisser limit; however, it is a great challenge for other solar cell materials to exceed the limit. Theoretically, the quantum dots solar cell can boost the power conversion efficiency up to 66% and even higher to 80%. Moreover, in changing the size of the quantum dots one can utilize the Sun’s broad spectrum of visible and infrared ranges. This review briefly overviews the present performance of different materials-based solar cells including silicon wafer, dye-sensitized, and organic solar cells. In addition, recent advances of the quantum dots based solar cells which utilize cadmium sulfide/selenide, lead sulfide/selenide, and new carbon dots as light harvesting materials has been reviewed. A future outlook is sketched as to how one could improve the efficiency up to 10% from the current highest efficiency of 6.6%.

  10. Genetic mapping of rust resistance genes in confection sunflower line HA-R6 and oilseed line RHA 397.

    Science.gov (United States)

    Gong, L; Gulya, T J; Markell, S G; Hulke, B S; Qi, L L

    2013-08-01

    Few widely effective resistance sources to sunflower rust, incited by Puccinia helianthi Schwein., have been identified in confection sunflower (Helianthus annuus L.). The USDA inbred line HA-R6 is one of the few confection sunflower lines resistant to rust. A previous allelism test indicated that rust resistance genes in HA-R6 and RHA 397, an oilseed-type restorer line, are either allelic or closely linked; however, neither have been characterized nor molecularly mapped. The objectives of this study are (1) to locate the rust resistance genes in HA-R6 and RHA 397 on a molecular map, (2) to develop closely linked molecular markers for rust resistance diagnostics, and (3) to determine the resistance spectrum of two lines when compared with other rust-resistant lines. Two populations of 140 F2:3 families each from the crosses of HA 89, as susceptible parent, with HA-R6 and RHA 397 were inoculated with race 336 of P. helianthi in the greenhouse. The resistance genes (R-genes) in HA-R6 and RHA 397 were molecularly mapped to the lower end of linkage group 13, which encompasses a large R-gene cluster, and were designated as R 13a and R 13b, respectively. In the initial maps, SSR (simple sequence repeat) and InDel (insertion and deletion) markers revealed 2.8 and 8.2 cM flanking regions for R 13a and R 13b, respectively, linked with a common marker set of four co-segregating markers, ORS191, ORS316, ORS581, and ZVG61, in the distal side and one marker ORS464 in the proximal side. To identify new markers closer to the genes, sunflower RGC (resistance gene candidate) markers linked to the downy mildew R-gene Pl 8 and located at the same region as R 13a and R 13b were selected to screen the two F2 populations. The RGC markers RGC15/16 and a newly developed marker SUN14 designed from a BAC contig anchored by RGC251 further narrowed down the region flanking R 13a and R 13b to 1.1 and 0.1 cM, respectively. Both R 13a and R 13b are highly effective against all rust races

  11. Short- and long-distance control of root development by LjHAR1 during the juvenile stage of Lotus japonicus.

    Science.gov (United States)

    Buzas, Diana Mihaela; Gresshoff, Peter Michael

    2007-04-01

    The autoregulation of nodulation (AON) is a universal mechanism to legumes to control the extent of nodulation via a systemic circuit and if genetically altered, as in the Lotus japonicus har1-1 mutant, leads to hypernodulation and aberrant root development. Increased nodulation of har1-1 is associated with pleiotropic effects both in the absence and presence of the symbiosis. We used two different grafting techniques to investigate the control of the non-symbiotic retarded root growth phenotype of har1-1, and demonstrate that altered root growth in the non-symbiotic condition is controlled by the genotype of both the shoot and the root. Based on these results and on the Gresshoff and Delves [Plant genetic approaches to symbiotic nodulation and nitrogen fixation in legumes. Plant Gene Res 1986;3:159-206] AON model, we propose an advanced working model for control of root development by LjHAR1.

  12. Retrospective analysis of the non-surgical treatment of developmental dysplasia of the hip using Pavlik harness and Frejka pillow: comparison of both methods.

    Science.gov (United States)

    Czubak, Jarosław; Piontek, Tomasz; Niciejewski, Krzysztof; Magnowski, Piotr; Majek, Marcin; Płończak, Maciej

    2004-02-28

    Background. Several different orthoses are used for the treatment of developmental dysplasia of the hip (DDH). The most popular are the Frejka pillow, the Pavlik harness, the von Rosen splint, and the Koszla splint. The purpose of our study was a retrospective comparative analysis of the non-surgical treatment of DDH using Pavlik harness and Frejka pillow. Material and methods. We studied 238 children (438 hips), 213 girls and 25 boys. In this group 143 children were treated using the Frejka pillow and 95 using the Pavlik harness. The development of the infants' hips was assessed by ultrasonography. Results. 89% of the hips treated with Frejka pillow and 95% treated with Pavlik harness were successfully reduced. In children with dysplastic hips diagnosed before age 24 weeks, the Pavlik harness is effective. In childrern diagnosed after 24 weeks of life the Frejka pillow is more effective. In spite of appropriate treatment using both methods, avascular necrosis was found in 12% of the hips treated with Frejka pillow and 7% in the Pavlik group. Conclusions. Pavlik-stabilized hips in human position to promote concentric reduction shorten the duration of treatment, allow the mother to clean the infant easily and decrease the risk of avascular necrosis. The position achieved by using the Frejka pillow is not as appropriate, but the results are better than with the Pavlik harness in children diagnosed after 6 months of age.

  13. Harnessing the power of mobile technologies for collaborating, crowdsourcing, and creating

    Science.gov (United States)

    Crompton, H.

    2015-12-01

    Today's digital technologies can have a powerful influence on teaching and learning. M-learning and u-learning in particular are changing pedagogical practice. Sub categories are rapidly emerging, such as context-aware ubiquitous learning, that involve students learning subject content while immersed in authentic and relevant surroundings. Learning cultures are a nebulous blend of traditions, values, beliefs, and rituals built up over time. For a long time, education has long been conceived as classroom-based and predominantly sedentary (Merchant, 2012). Recent mobile technologies are disrupting this culture in favor of learning that is contextualized, personalized, on demand, and ubiquitous (Crompton, 2013). 21st century students are a different breed than past generations (Prensky, 2001). These students have grown up in a time that has not only altered their perceptions and practices but modified the wiring of the brain through neuroplasticity (Crompton, 2012). Students now cognitively receive information quickly through non-linear methods (Gross, 2003, Oblinger & Oblinger, 2005). They think differently. They also seem to be attached to mobile devices 24/7, although the content of the lesson does not match what they seem to be doing on the mobile devices. This presentation will showcase how to get your students to harness the power of mobile devices for educational purposes. For example, students in your classes will be using devices to collaborate on activities with Google Forms, crowdsourcing the best class questions in Slido, and screencasting thoughts and ideas to share with others with Educreations. These are examples of free apps or Web 2.0 tools that can be used on all the major mobile platforms. Crompton, H. (2013). Mobile learning: New approach, new theory. In Z. L. Berge & L. Y. Muilenburg (Eds.), Handbook of mobile learning (pp. 47-57). Prensky, M. (2001). Digital natives, digital immigrants. Mcb University Press, 9(5). Oblinger, D., & Oblinger, J

  14. Hydrodynamic modeling and feasibility study of harnessing tidal power at the Bay of Fundy

    Science.gov (United States)

    Chang, Jen

    Due to rising fuel costs and environmental concerns, energy generation from alternative power source has become one of the most important issues in energy policy. Tidal power is one of the alternative energy sources. The tidal range at the Bay of Fundy is the largest in the world (approximately 16 meters). It represents a prime location for harnessing tidal power using the daily rising and ebbing tide. In this study, a two dimensional finite element model has been developed and applied to simulate the tidal responses, including water level and flow velocity, in the Bay of Fundy region. The simulation results are used to choose the suitable location for energy development and to predict possible energy generated from different types of generation methods. Fluid motion is assumed to be governed by the shallow water equation since the wave length associated with tide is much longer than the water depth in the Bay of Fundy. By using a real time series of water elevation at the entrance of the bay, the computer model finds tidal response for each node in the study area, which is then verified by the observation record from several tidal gauge stations inside the bay. This study shows that the at-site cost of the energy for barrage type tidal power plants is around 0.065 to 0.097 per kWh at the recommended Shepody Bay, Cumberland Basin, and Cobequid Bay. The cost of energy for the current turbine type tidal power plants is 0.13/kWh to 0.24/kWh at the area with highest current velocity. Compared with the recent bill of the local power company, the at-site unit cost of energy from the barrage type of tidal power plant is feasible, but the environmental concerns of channel blocking by barrage present a formidable constraint. For the current turbine type of tidal power plant, even the most suitable sites are not financially feasible under current technology, but this type of power generation may become feasible as oil prices continue to increase and more efficient turbines

  15. Determining Damping Trends from a Range of Cable Harness Assemblies on a Launch Vehicle Panel from Test Measurements

    Science.gov (United States)

    Smith, Andrew; Davis, R. Ben; LaVerde, Bruce; Jones, Douglas

    2012-01-01

    The team of authors at Marshall Space Flight Center (MSFC) has been investigating estimating techniques for the vibration response of launch vehicle panels excited by acoustics and/or aero-fluctuating pressures. Validation of the approaches used to estimate these environments based on ground tests of flight like hardware is of major importance to new vehicle programs. The team at MSFC has recently expanded upon the first series of ground test cases completed in December 2010. The follow on tests recently completed are intended to illustrate differences in damping that might be expected when cable harnesses are added to the configurations under test. This validation study examines the effect on vibroacoustic response resulting from the installation of cable bundles on a curved orthogrid panel. Of interest is the level of damping provided by the installation of the cable bundles and whether this damping could be potentially leveraged in launch vehicle design. The results of this test are compared with baseline acoustic response tests without cables. Damping estimates from the measured response data are made using a new software tool that employs a finite element model (FEM) of the panel in conjunction with advanced optimization techniques. This paper will report on the \\damping trend differences. observed from response measurements for several different configurations of cable harnesses. The data should assist vibroacoustics engineers to make more informed damping assumptions when calculating vibration response estimates when using model based analysis approach. Achieving conservative estimates that have more flight like accuracy is desired. The paper may also assist analysts in determining how ground test data may relate to expected flight response levels. Empirical response estimates may also need to be adjusted if the measured response used as an input to the study came from a test article without flight like cable harnesses.

  16. The Elusive Path of Brain Tissue Oxygenation and Cerebral Perfusion in Harness Hang Syncope in Mountain Climbers.

    Science.gov (United States)

    Lanfranconi, Francesca; Pollastri, Luca; Corna, Giovanni; Bartesaghi, Manuela; Novarina, Massimiliano; Ferri, Alessandra; Miserocchi, Giuseppe Andrea

    2017-10-05

    Lanfranconi, Francesca, Luca Pollastri, Giovanni Corna, Manuela Bartesaghi, Massimiliano Novarina, Alessandra Ferri, and Giuseppe Andrea Miserocchi. The elusive path of brain tissue oxygenation and cerebral perfusion in harness hang syncope in mountain climbers. High Alt Med Biol. 18:000-000, 2017. Harness hang syncope (HHS) is a risk that specifically affects wide ranges of situations requiring safety harnesses in mountains. An irreversible orthostatic stasis could lead to death if a prompt rescue is not performed. We aimed at evaluating the risk of developing HHS and at identifying the characteristics related to the pathogenesis of HHS. Forty adults (aged 39.1 [8.2] years) were enrolled in a suspension test lasting about 28.7 (11.4) minutes. We measured cardiovascular parameters, and near infrared spectroscopy (NIRS) was used to assess cerebral hypoxia by changes in the concentration of oxyhemoglobin (Δ[HbO2]) and de-oxyhemoglobin (Δ[HHb]). In the four participants who developed HHS: (1) systolic and diastolic blood pressure showed ample oscillations with a final abrupt drop (∼30 mmHg); (2) Δ[HbO2] increased after 8-12 minutes of suspension and reached a plateau before HHS; and (3) Δ[HHb] decreased with a final abrupt increase before syncope. Participants who developed HHS failed to activate cardiovascular reflexes that usually safeguard O2 availability to match the metabolic needs of the brain tissue. Since cerebral hypoxia was detected as an early phenomenon by Δ[HbO2] and Δ[HHb] changes, NIRS measurement appears to be the most important parameter to monitor the onset of HHS.

  17. Kan dansk selskabsret forlange, at en filial af et udenlandsk selskab har et selvstændigt navn?

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2013-01-01

    . Konklusionerne er følgende: (1) Der er ikke et tilstrækkeligt retligt grundlag for Erhvervsstyrelsens krav om, at registrering af en dansk filial af et udenlandsk selskab kun kan finde sted, hvis filialen har et selvstændigt navn, der gengives i filialnavnet ud over opfyldelsen af de krav, der følger af...... denne årsag. En argumentation på grundlag af EU-retten er derfor relevant også for et selskab fra et andet OECD-land, der vil etablere filial i Danmark, jf. OECD's 3. beslutning om indlændingebehandling af udenlandske virksomheder....

  18. Harnessing the Risk-Related Data Supply Chain: An Information Architecture Approach to Enriching Human System Research and Operations Knowledge

    Science.gov (United States)

    Buquo, Lynn E.; Johnson-Throop, Kathy A.

    2011-01-01

    An Information Architecture facilitates the understanding and, hence, harnessing of the human system risk-related data supply chain which enhances the ability to securely collect, integrate, and share data assets that improve human system research and operations. By mapping the risk-related data flow from raw data to useable information and knowledge (think of it as a data supply chain), the Human Research Program (HRP) and Space Life Science Directorate (SLSD) are building an information architecture plan to leverage their existing, and often shared, IT infrastructure.

  19. Hvilken betydning har ergoterapi- og fysioterapiydelser i Akut Sengeafsnit og Akut Hjerteafsnit, set i et tværfagligt perspektiv?

    DEFF Research Database (Denmark)

    Hansen Bruun, Inge; Nørgaard, Birgitte

    2012-01-01

    terapeutiske ydelser vil blive belyst med data fra journalaudit, spørgeskemaer og fokusgruppe-interview. Metodetrianguleringen er valgt, da der ønskes såvel hypotesetestende som beskrivende og uddybende data. Vigtigste variable: Der gennemgås i alt 96 journaler med henblik på at afdække hvorvidt...... fysioterapeuter i Akut Sengeafsnit gennemsnitlig har henholdsvis 1,5 og 1,4 kontakter med patienterne. Der er endnu ingen resultater relateret til det aktuelle projekt. Konklusioner: Projektet er igangsat pr. 1. marts, 2012, hvorfor det endnu er for tidligt at præsentere resultater....

  20. Harness That S.O.B.: Distributing Remote Sensing Analysis in a Small Office/Business

    Science.gov (United States)

    Kramer, J.; Combe, J.; McCord, T. B.

    2009-12-01

    Researchers in a small office/business (SOB) operate with limited funding, equipment, and software availability. To mitigate these issues, we developed a distributed computing framework that: 1) leverages open source software to implement functionality otherwise reliant on proprietary software and 2) harnesses the unused power of (semi-)idle office computers with mixed operating systems (OSes). This abstract outlines some reasons for the effort, its conceptual basis and implementation, and provides brief speedup results. The Multiple-Endmember Linear Spectral Unmixing Model (MELSUM)1 processes remote-sensing (hyper-)spectral images. The algorithm is computationally expensive, sometimes taking a full week or more for a 1 million pixel/100 wavelength image. Analysis of pixels is independent, so a large benefit can be gained from parallel processing techniques. Job concurrency is limited by the number of active processing units. MELSUM was originally written in the Interactive Data Language (IDL). Despite its multi-threading capabilities, an IDL instance executes on a single machine, and so concurrency is limited by the machine's number of central processing units (CPUs). Network distribution can access more CPUs to provide a greater speedup, while also taking advantage of (often) underutilized extant equipment. appropriately integrating open source software magnifies the impact by avoiding the purchase of additional licenses. Our method of distribution breaks into four conceptual parts: 1) the top- or task-level user interface; 2) a mid-level program that manages hosts and jobs, called the distribution server; 3) a low-level executable for individual pixel calculations; and 4) a control program to synchronize sequential sub-tasks. Each part is a separate OS process, passing information via shell commands and/or temporary files. While the control and low-level executables are short-lived, the top-level program and distribution server run (at least) for the entirety of

  1. Three decades of harnessing the GPS data explosion for geophysics (Vening Meinesz Medal Lecture)

    Science.gov (United States)

    Blewitt, Geoffrey

    2015-04-01

    In this presentation, I attempt to convey the immensity of the task that faced the geodesy community three decades ago, and continues to challenge us, to harness all potentially valuable GPS data available in the world for geophysical science. It would be fair to see that three decades ago, we were struggling with controlled tests just to get GPS geodesy working, and had little time to imagine the flood of data today. Yet the geodesy community has succeeded in meeting this challenge. Today, for example, the Nevada Geodetic Laboratory produces and makes publicly available coordinate time series for over 12,000 geodetic GPS station around the globe with various data intervals, latencies, and reference frames. About 8,000 stations have their daily time series updated every week, with 4,000 being updated the next day with coordinates at daily and 5 minute intervals. About 2,000 stations have their time series updated every hour with coordinates at 5 minute intervals. I will show examples of how these time series are being used by NGL and many other scientists to study a wide variety of geophysical topics, including plate tectonics, earthquake modeling, seismic and tsunami hazard, volcanic deformation, water resources, mountain growth, terrestrial reference frame realization, glacial isostatic adjustment, ice sheet melting, sea level rise and coastal subsidence, and even fundamental physics, using GPS atomic clocks to probe the nature of dark matter in the universe. The explosion in GPS data has challenged us to invent new data processing algorithms and develop robust automation in order to keep up with the flood. This explosion has been exponential, and therefore it can be said that it is not a recent phenomena, but rather that it began in the earliest years of GPS geodesy, and has always posed a challenge to us. Over the course of my post-doctoral career starting in late 1985, I have had the good fortune to witness the key developments that have taken place since the

  2. "Harnessing genomics to improve health in Africa" – an executive course to support genomics policy

    Directory of Open Access Journals (Sweden)

    Singer Peter A

    2005-01-01

    Full Text Available Abstract Background Africa in the twenty-first century is faced with a heavy burden of disease, combined with ill-equipped medical systems and underdeveloped technological capacity. A major challenge for the international community is to bring scientific and technological advances like genomics to bear on the health priorities of poorer countries. The New Partnership for Africa's Development has identified science and technology as a key platform for Africa's renewal. Recognizing the timeliness of this issue, the African Centre for Technology Studies and the University of Toronto Joint Centre for Bioethics co-organized a course on Genomics and Public Health Policy in Nairobi, Kenya, the first of a series of similar courses to take place in the developing world. This article presents the findings and recommendations that emerged from this process, recommendations which suggest that a regional approach to developing sound science and technology policies is the key to harnessing genome-related biotechnology to improve health and contribute to human development in Africa. Methods The objectives of the course were to familiarize participants with the current status and implications of genomics for health in Africa; to provide frameworks for analyzing and debating the policy and ethical questions; and to begin developing a network across different sectors by sharing perspectives and building relationships. To achieve these goals the course brought together a diverse group of stakeholders from academic research centres, the media, non-governmental, voluntary and legal organizations to stimulate multi-sectoral debate around issues of policy. Topics included scientific advances in genomics innovation systems and business models, international regulatory frameworks, as well as ethical and legal issues. Results Seven main recommendations emerged: establish a network for sustained dialogue among participants; identify champions among politicians; use the

  3. The assessment of global thermo-energy performances of existing district heating systems optimized by harnessing renewable energy sources

    Science.gov (United States)

    Şoimoşan, Teodora M.; Danku, Gelu; Felseghi, Raluca A.

    2017-12-01

    Within the thermo-energy optimization process of an existing heating system, the increase of the system's energy efficiency and speeding-up the transition to green energy use are pursued. The concept of multi-energy district heating system, with high harnessing levels of the renewable energy sources (RES) in order to produce heat, is expected to be the key-element in the future urban energy infrastructure, due to the important role it can have in the strategies of optimizing and decarbonizing the existing district heating systems. The issues that arise are related to the efficient integration of different technologies of harnessing renewable energy sources in the energy mix and to the increase of the participation levels of RES, respectively. For the holistic modeling of the district heating system, the concept of the energy hub was used, where the synergy of different primary forms of entered energy provides the system a high degree energy security and flexibility in operation. The optimization of energy flows within the energy hub allows the optimization of the thermo-energy district system in order to approach the dual concept of smart city & smart energy.

  4. Harnessing the native type I-B CRISPR-Cas for genome editing in a polyploid archaeon.

    Science.gov (United States)

    Cheng, Feiyue; Gong, Luyao; Zhao, Dahe; Yang, Haibo; Zhou, Jian; Li, Ming; Xiang, Hua

    2017-11-20

    Research on CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated protein) systems has led to the revolutionary CRISPR/Cas9 genome editing technique. However, for most archaea and half of bacteria, exploitation of their native CRISPR-Cas machineries may be more straightforward and convenient. In this study, we harnessed the native type I-B CRISPR-Cas system for precise genome editing in the polyploid haloarchaeon Haloarcula hispanica. After testing different designs, the editing tool was optimized to be a single plasmid that carries both the self-targeting mini-CRISPR and a 600-800 bp donor. Significantly, chromosomal modifications, such as gene deletion, gene tagging or single nucleotide substitution, were precisely introduced into the vast majority of the transformants. Moreover, we showed that simultaneous editing of two genomic loci could also be readily achieved by one step. In summary, our data demonstrate that the haloarchaeal CRISPR-Cas system can be harnessed for genome editing in this polyploid archaeon, and highlight the convenience and efficiency of the native CRISPR-based genome editing strategy. Copyright © 2017 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.

  5. Den koreanske bølgen - En kulturvitenskapelig studie av sørkoreansk populærkultur, og hvordan den har nådd Vesten

    OpenAIRE

    Kvinge, Kristin Øyvindsdatter

    2016-01-01

    Hensikten med denne oppgaven er å se på den koreanske bølgen, som ofte refereres til som Hallyu. Den tar for seg både Hallyu som innhold og Hallyu som fenomen. Den koreanske bølgen har spredd seg hurtig i løpet av de siste 20 årene, noe som har bidratt til å gjøre Korea til en av de hurtigst økende økonomiene i den moderne tid. Denne oppgaven forsøker å se nærmere på hvordan Hallyu har nådd Vesten, med fokus på Europa og Norge. Før analysen vil oppgaven se nærmere på hv...

  6. Vilken betydelse har karisma i dagens samhälle? : En socialkonstruktivistisk studie av karisma i självhjälpslitteratur

    OpenAIRE

    Sandstedt, Elin

    2012-01-01

    Karisma är ett fenomen som under lång tid väckt stort intresse och fascination bland människor, däribland mig själv. Däremot är begreppet aningen diffust och det har därför varit svårt att hitta en entydig definition av karisma. För att undersöka dimensionerna av karisma har jag i denna uppsats valt att undersöka karismans betydelse i dagens samhälle. Syftet med undersökningen har varit att undersöka hur fenomenet karisma som begrepp konstrueras i en bestämd social kontext i samhället idag, v...

  7. A Reliable and Valid Objective Structured Assessment of Technical Skill for the Application of a Pavlik Harness Based on International Expert Consensus.

    Science.gov (United States)

    Bradley, Catharine S; Moktar, Joel; Maxwell, Alexandra; Wedge, John H; Murnaghan, Michael L; Kelley, Simon P

    2016-01-01

    The use of competency-based training is increasing in medical education as it offers individualized learning opportunities to master required skills. Inherent to this method of teaching is the need for standardized and objective assessments of skill mastery. In orthopaedic surgery, educational programs have focused on surgical skills with lesser emphasis on nonoperative techniques. Accordingly, formal evaluation tools specific to Pavlik Harness application do not exist, despite its widespread use and potential complications from inappropriate application. This study sought to develop a reliable and valid evaluation tool based on international expert consensus to standardize and evaluate Pavlik Harness application for developmental dysplasia of the hip. Consensus was sought from 10 content experts using Delphi methodology. Resulting items formed the Objective Structured Assessment of Technical Skill (OSATS). Thirty-five participants were selected into 3 a priori groups (expert, intermediate and novice) based on Pavlik Harness experience. On 2 occasions, 3 content experts assessed randomized and deidentified videotapes of each participant applying a Pavlik Harness to an infant model using the OSATS and global rating scales (GRS). The reliability and validity of the OSATS was determined with intraclass (ICC) and Pearson correlations and analysis of variance (ANOVA). Consensus was obtained after 2 rounds of structured surveying and resulted in a 25-item OSATS. The reliability of the OSATS was excellent with an ICC of 0.96 for interrater and 0.98 for test-retest reliability. Construct validity was excellent with high correlations between OSATS and GRS (>0.90). In addition, the OSATS discriminated between expert, intermediate, and novice users. We have developed a competency-based evaluation tool for Pavlik Harness application based on consensus from international experts. The OSATS has been shown to be a reliable and valid method for assessing Pavlik Harness application

  8. Depresjon etter slag – en undervurdert diagnose? - hvordan kan sykepleiere bidra til å forebygge depresjon hos pasient som har hatt apoplexia cerebri?

    OpenAIRE

    Bye, Terje; Skotte, Kjetil

    2010-01-01

    Oppgaven handler om hvordan sykepleiere kan bidra til å forebygge depresjon hos pasienter som har hatt apoplexia cerebri, en sykdom som for mange endrer livet radikalt. Vi ønsker med oppgaven å sette fokus på helhetlig sykepleie og på at sykepleier kan bidra til å styrke slagpasienters psykiske helse ved å være et medmenneske som tar i bruk sykepleiefaglige teknikker for å skape håp og optimisme. Først har vi kartlagt enkelt sykdomslæren rundt apoplexia cerebri. Deretter definert depresjon, r...

  9. Study of Green Shipping Technologies - Harnessing Wind, Waves and Solar Power in New Generation Marine Propulsion Systems

    Directory of Open Access Journals (Sweden)

    Grzegorz Rutkowski

    2016-12-01

    Full Text Available The purpose and scope of this paper is to describe the complexity of the new generation marine propulsion technologies implemented in the shipping industry to promote green ships concept and change the view of sea transportation to a more ecological and environment-friendly. Harnessing wind, waves and solar power in shipping industry can help the ship’s owners reduce the operational costs. Reducing fuel consumption results in producing less emissions and provides a clean source of renewable energy. Green shipping technologies can also effectively increase the operating range of vessels and help drive sea transportation towards a greener future and contribute to the global reduction of harmful gas emissions from the world's shipping fleets.

  10. Harnessing cognitive neuroscience to develop new treatments for improving cognition in schizophrenia: CNTRICS selected cognitive paradigms for animal models.

    Science.gov (United States)

    Moore, Holly; Geyer, Mark A; Carter, Cameron S; Barch, Deanna M

    2013-11-01

    Over the past two decades, the awareness of the disabling and treatment-refractory effects of impaired cognition in schizophrenia has increased dramatically. In response to this still unmet need in the treatment of schizophrenia, the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative was developed. The goal of CNTRICS is to harness cognitive neuroscience to develop a brain-based set of tools for measuring cognition in schizophrenia and to test new treatments. CNTRICS meetings focused on development of tasks with cognitive construct validity for use in both human and animal model studies. This special issue presents papers discussing the cognitive testing paradigms selected by CNTRICS for animal model systems. These paradigms are designed to measure cognitive constructs within the domains of perception, attention, executive function, working memory, object/relational long-term memory, and social/affective processes. Copyright © 2013. Published by Elsevier Ltd.

  11. Harnessing the hydropower potential in Africa: What should be the place and role of Grand Inga hydropower project?

    Energy Technology Data Exchange (ETDEWEB)

    Fall, Latsoucabe

    2010-09-15

    Harnessing Africa's huge hydropower potential should be made a priority for the sustainable development of the Continent. Particularly, Grand Inga hydropower project in DRC, due to its gigantic size (40,000 MW) and favourable natural characteristics, could be 'Africa's flagship Project of the 21st Century' offering enormous comparative advantages and opportunities for the benefits of the entire African Continent. Nevertheless, to make it a feasible and palpable 'Model Project', capable of producing clean and affordable energy, the paper tries to respond to key questions on the several daunting challenges to address for its sustainable, cost-effective and timely development and operation.

  12. Microbes at Surface-Air Interfaces: The Metabolic Harnessing of Relative Humidity,Surface Hygroscopicity and Oligotrophy or Resilience

    Directory of Open Access Journals (Sweden)

    Wendy Stone

    2016-09-01

    Full Text Available The human environment is predominantly not aqueous, and microbes are ubiquitous at the surface-air interfaces with which we interact. Yet microbial studies at surface-air interfaces are largely survival-oriented, whilst microbial metabolism has overwhelmingly been investigated from the perspective of liquid saturation. This study explored microbial survival and metabolism under desiccation, particularly the influence of relative humidity, surface hygroscopicity, and nutrient availability on the interchange between these two types of behavior. The combination of a hygroscopic matrix (i.e., clay or 4,000 MW polyethylene glycol and high relative humidity (RH resulted in persistent measurable microbial metabolism during desiccation. In contrast, no microbial metabolism was detected at (a hygroscopic interfaces at low RH, and (b less hygroscopic interfaces (ie., sand and plastic/glass at high or low RH. Cell survival was conversely inhibited at high RH and promoted at low RH, irrespective of surface hygroscopicity. Based on this demonstration of metabolic persistence and survival inhibition at high relative humidity, it was proposed that biofilm metabolic rates might inversely influence whole-biofilm resilience, with ‘resilience’ defined in this study as a biofilm’s capacity to recover from desiccation. The concept of whole-biofilm resilience being promoted by oligotrophy was supported in desiccation-tolerant Arthrobacter spp. biofilms, but not in desiccation-sensitive Pseudomonas aeruginosa biofilms. The ability of microbes to interact with surfaces to harness water vapor during desiccation was demonstrated, and potentially to harness oligotrophy (the most ubiquitous natural condition facing microbes for adaptation to desiccation.

  13. [Social marketers' lack of success in using CSM discipline to harness commercial resources and increase contraceptive prevalence].

    Science.gov (United States)

    Davies, J

    1984-01-01

    Social marketers have certainly shown that the CSM discipline can quickly and cost-effectively harness commercial resources to increase contraceptive prevalence. But why hasn't the social marketing idea caught on in more countries? According to Social Marketing Forum, only a tiny number of countries have active programs after more than a decade of effort. The most likely reason for this lack of success is doubt and fear on the part of both developing countries' officials and donor agencies about allowing marketing enthusiasts--with our very noticeable advertising methods--to join the family planning fight. And what has our answer been? Usually, a head-on retort such as, "But look at all the condoms we've sold]" And that gets us nowhere, because the successful peddling of 1 not-so-impressive method doesn't begin to balance the fears of a possible backlash that brash condom promotions could bring down on official heads. The lesson we should be learning is that social marketers possess to narrow an outlook and promote a small range of products that don't enthuse decisionmakers. Hence, we are often perceived as condom salesmen--and not much more. What should we be doing? We should be selling the idea of using private sector experience to assist national development. That means social development, particularly improved health, family planning and women's education. These 3 activities have proven effective in reducing fertility and would add up to a marketing opportunity--a longterm challenge that should enthuse dicisionmakers, private sector entrepreneurs and donor agencies alike. Further, our model--the commercial sector--is renowned for branching out and secceeding in a broad range of endeavors. As an example, Procter and Gamble uses separate divisions to market different products. Initiatives already exist in many countries to harness the private sector as a development tool. Social marketers should be leading the initiative--and benefitting from it, too. full text

  14. Improving adherence to safe prescription guidelines for Dapsone: harnessing an enhanced electronic medical records system and a team approach.

    Science.gov (United States)

    Neoh, Ching Yin; Tian, Elizabeth A L; Choi, Cindy; Leong, Hui Hui; Tan, Audrey W H; Chan, Roy K W

    2012-03-01

    Dapsone is a commonly prescribed medication in dermatological practice. Its use is associated with a broad spectrum of adverse effects. Careful selection and monitoring of patients on dapsone are paramount in the prevention and early recognition of adverse effects. We designed a risk-management program for dapsone at National Skin Centre, Singapore, enhancing an existing electronic medical records system and harnessing a team approach involving the nurses. This includes the performance of key laboratory tests before and after starting dapsone, ensuring adequate counseling before starting dapsone and screening for adverse effects using a questionnaire every visit. This system of dapsone prescription efficiently improved the adherence to safe prescription and monitoring guidelines. Average adherence rates for key safety parameters improved from 61.4% pre-implementation to 95.3% at six months and were sustained at 12 months at 91.3%. Percentage of follow-up cases in which all three key monitoring parameters were fulfilled increased from 9.5% to 79.6% (p=0.0001) after 12months. The percentage of new patients in which all four key monitoring parameters were met increased from 50% to 80%. It was not statistically significant possibly because of small patient numbers. This project has also translated into enhanced patient safety with dapsone dosages adjusted in 17 patients who experienced mild adverse effects. No severe adverse effects to dapsone were observed in the 12-month period. This example of risk management for dapsone may serve as a model for institutions looking at harnessing information technology and a team approach for safer prescription of high-alert medications. © 2012 The International Society of Dermatology.

  15. Hvad har betydning for udviklingen i cyklingen? Analyse af brug af cykel på ture i transportvaneundersøgelsen 1996-2013

    DEFF Research Database (Denmark)

    Nielsen, Thomas Alexander Sick; Mulalic, Ismir; Christiansen, Hjalmar

    2015-01-01

    Beskrivende analyser har peget på faldende cykelandel igennem de sidste 20 år og tiltagende geografiske forskelle. Paperet søger verifikation af disse forhold ved at inddrage og kontrollere for et større sæt af faktorer, der kan have betydning for cyklingen. Resultaterne bekræfter at der er en al...

  16. Quantifying low back peak and cumulative loads in open and senior sheep shearers in New Zealand: examining the effects of a trunk harness.

    Science.gov (United States)

    Gregory, Diane E; Milosavljevic, Stephan; Callaghan, Jack P

    2006-08-15

    Sheep shearing requires shearers to adopt sustained flexed postures for prolonged periods of time and has been associated with an increased risk of developing low back pain (LBP). However, these postures do not generally result in acute compressive values at L4/L5 exceeding the action limit proposed by the National Institute for Occupational Safety and Health, despite the high prevalence of LBP in this occupation. Therefore, it may not be peak loading that is responsible for LBP in this occupation but instead it may be the effect of cumulative loading over the course of a workday. The primary purpose of this research was to quantify the low back cumulative load exposure in 12 sheep shearers with and without the aid of a commercial trunk harness. Results revealed a significant reduction in the magnitude of cumulative compression with the use of the trunk harness and therefore its use may potentially reduce the risk of injury. The use of the trunk harness also reduced the time spent in axially twisted postures, which have been associated with LBP. However, using the trunk harness also resulted in increased time spent in laterally bent postures, which has been associated with increased risk for pain and injury.

  17. Från åkerbruk och fäboddrift : Den svenska vokala folkmusiken nu och då, har sångsättet förändrats?

    OpenAIRE

    Ludvigson, Emma

    2009-01-01

    Arbetet behandlar sättet att sjunga folkvisan från bondesamhället till modern tid. Mitt syfte är att ta reda på om sättet att sjunga folkvisan har förändrats genom åren, vidare vill jag undersöka hur folksången har förändrats och vad det beror på. Jag har intervjuat fem kvinnor som alla är verksamma folksångerskor, använt mig av litteraturstudium och lyssnat till arkivinspelningar. I mitt arbete har jag kommit fram till att folksången har förändrats under årens lopp. En skillnad som blev tydl...

  18. Etisk kompetanseheving i norske kommuner – hva er gjort, og hva har vært levedyktig over tid?

    Directory of Open Access Journals (Sweden)

    Elisabeth Gjerberg

    2014-11-01

    Full Text Available De senere år har pleie- og omsorgstjenesten i mange norske kommuner startet med ulike former for etikkarbeid, oftest initiert av KS’ prosjekt “Samarbeid om etisk kompetanseheving”. Hensikten med vår studie var å evaluere innsatsen i de kommunene som deltok i prosjektet fra starten av, med vekt på hvilke tiltak som var iverksatt, hvilke virksomheter dette omfattet, og om tiltakene har fortsatt utover prosjektperioden. Studien har et kvalitativt design. Materialet er hovedsakelig basert på telefonintervjuer med kontaktpersoner for etikksatsingen i 34 kommuner. Det transkriberte materialet er analysert ved kvalitativ innholdsanalyse. Med unntak av fem kommuner som aldri kom i gang med etikkarbeidet, hadde de fleste startet etikkrefleksjon innenfor flere tjenester, oftest i sykehjem og hjemmetjenester. Noen kommuner hadde imidlertid ikke klart å videreføre etikkarbeidet utover en prosjektperiode. Det var stor variasjon både i etikkarbeidets forankring i kommunen, omfang, hyppighet og metoder. Et gjennomgående funn er vektlegging av behovet for etikkkompetanse og oppfølging av dem som skal lede etikkarbeidet. Flertallet av kommunene som fortsatt gjennomfører etikkrefleksjon, tar utgangspunkt i egen praksis, men et mindretall anvender strukturerte metoder. Dersom etikkarbeidet i kommunen skal være levedyktig over tid, bør arbeidet forankres på flere nivåer i organisasjonen, og de som skal lede dette arbeidet, bør få styrket sin kompetanse i etikk og etikkrefleksjon.Nøkkelord: etikk, evaluering, kommunehelsetjenestenEnglish summary: Building ethical competence in Norwegian municipalities: What has been done and what has been sustainable?“Cooperation for building ethics competence” is a national project aimed to stimulate moral reflection and build competence in ethics in community health services in Norway. This article is based on an evaluation of the activities implemented by the first 34 participating municipalities

  19. Harnessing genomics to improve health in the Eastern Mediterranean Region – an executive course in genomics policy

    Directory of Open Access Journals (Sweden)

    Singer Peter A

    2005-01-01

    Full Text Available Abstract Background While innovations in medicine, science and technology have resulted in improved health and quality of life for many people, the benefits of modern medicine continue to elude millions of people in many parts of the world. To assess the potential of genomics to address health needs in EMR, the World Health Organization's Eastern Mediterranean Regional Office and the University of Toronto Joint Centre for Bioethics jointly organized a Genomics and Public Health Policy Executive Course, held September 20th–23rd, 2003, in Muscat, Oman. The 4-day course was sponsored by WHO-EMRO with additional support from the Canadian Program in Genomics and Global Health. The overall objective of the course was to collectively explore how to best harness genomics to improve health in the region. This article presents the course findings and recommendations for genomics policy in EMR. Methods The course brought together senior representatives from academia, biotechnology companies, regulatory bodies, media, voluntary, and legal organizations to engage in discussion. Topics covered included scientific advances in genomics, followed by innovations in business models, public sector perspectives, ethics, legal issues and national innovation systems. Results A set of recommendations, summarized below, was formulated for the Regional Office, the Member States and for individuals. • Advocacy for genomics and biotechnology for political leadership; • Networking between member states to share information, expertise, training, and regional cooperation in biotechnology; coordination of national surveys for assessment of health biotechnology innovation systems, science capacity, government policies, legislation and regulations, intellectual property policies, private sector activity; • Creation in each member country of an effective National Body on genomics, biotechnology and health to: - formulate national biotechnology strategies - raise

  20. CoDiagnose: Interactive software to harness collaborative diagnoses and to increase diagnostic accuracy amongst junior physicians.

    Science.gov (United States)

    McComb, Steven; Bond, Raymond R

    2015-01-01

    Many studies have been conducted that highlight the prevalence of misdiagnoses within the medical profession and the statistically poor diagnostic accuracy rates associated with junior clinicians. There is evidence that crowdsourcing and multiple medical opinions can improve the veracity of a diagnosis. This paper proposes a cloud based prototype that makes use of interactive web technologies along with the concepts of crowdsourcing and e-learning to improve diagnostic accuracy rates amongst junior doctors. Existing approaches in this field are analysed to identify potential gaps and opportunities. Sample representations of both junior and senior clinicians are surveyed to establish the feasibility of adopting collaborative diagnostics. It is theorised that the prototype developed in this work will harness the experience and knowledge of expert clinicians. The prototype is a fully responsive web-based and feature-rich interactive system that has been developed using the latest Internet technologies. It has been evaluated using usability tests and a one month long trial involving a sample of end-users. Crowdsourcing is an innovative process in its infancy but the results being produced indicate a promising future for its use within medicine. The results offer an inclination that the prototype's usage could be attributed to improved diagnostic ability. However the findings need to be replicated in larger, independent samples.

  1. Ground reaction force and kinematic analysis of limb loading on two different beach sand tracks in harness trotters.

    Science.gov (United States)

    Crevier-Denoix, N; Robin, D; Pourcelot, P; Falala, S; Holden, L; Estoup, P; Desquilbet, L; Denoix, J M; Chateau, H

    2010-11-01

    Although beach training is commonly used in horses, limb loading on beach sand has never been investigated. A dynamometric horseshoe (DHS) is well adapted for this purpose. To compare ground reaction force (GRF) and fetlock kinematics measured in harness trotters on 2 tracks of beach sand with different water content. Two linear sand tracks were compared: firm wet sand (FWS, 19% moisture) vs. deep wet sand (DWS, 13.5% moisture). Four French trotters (550 ± 22 kg) were used. Their right forelimb was equipped with a DHS and skin markers. Each track was tested 3 times at 7 m/s. Each trial was filmed by a high-speed camera (600 Hz); DHS and speed data acquisition was performed at 10 kHz on 10 consecutive strides. All recordings were synchronised. The components Fx (parallel to the hoof solar surface) and Fz (perpendicular) of the GRF were considered. For 3 horses the fetlock angle and forelimb axis-track angle at landing were measured. Statistical differences were tested using the GLM procedure (SAS; P fetlock extension was less and delayed on DWS. This study confirms that trotting on deep sand overall reduces maximal GRF and induces a more progressive limb loading. However, it increases the propulsive effort and likely superficial digital flexor tendon tension at the end of stance, which should be taken into account in beach training. © 2010 EVJ Ltd.

  2. Inspiration in the harness of daily labor. Darwin, botany, and the triumph of evolution, 1859-1868.

    Science.gov (United States)

    Bellon, Richard

    2011-09-01

    Charles Darwin hoped that a large body of working naturalists would embrace evolution after the Origin of Species appeared in late 1859. He was disappointed. His evolutionary ideas at first made painfully little progress in the scientific community. But by 1863 the tide had turned dramatically, and within five years evolution became scientific orthodoxy in Britain. The Origin's reception followed this peculiar trajectory because Darwin had not initially tied its theory to productive original scientific investigation, which left him vulnerable to charges of reckless speculation. The debate changed with his successful application of evolution to original problems, most notably orchid fertilization, the subject of a well-received book in 1862. Most of Darwin's colleagues found the argument of the Origin convincing when they realized that it functioned productively in the day-to-day work of science-and not before. The conceptual force of the Origin, however outwardly persuasive, acquired full scientific legitimacy only when placed "in the harness of daily labour".

  3. Upgrading Wood-Based Industries: Harnessing the Social Network of Small-Scale Furniture Producers and Their Institutions

    Directory of Open Access Journals (Sweden)

    Melati ,

    2011-05-01

    Full Text Available Furniture is a major export commodity in Indonesia with a total value of USD 1.96 million in 2007.  Jepara District is one of the key location for wood furniture production with 15,271 furniture related business units employing 176,469 workers.  However, inefficiencies and power imbalances throughout the furniture value chain have resulted in overharvesting and uneven distribution of gains among the industry’s actors.  In contrast to price-setting international furniture retailers, small-scale producers enjoy the least value from their products.  In order to increase added value and competitiveness, small-scale furniture producers have made efforts to upgrade by harnessing their social network and institutions.  This paper describes small-scale furniture producers’ efforts to upgrade by utilising their social network and institutions in Jepara.  Data was collected through in-depth interviews with members of the small-scale furniture producers’ association.  The research provides insight into the nature of social networks and information flow and develops future scenarios to upgrade.  The scenarios will not only benefit the furniture industry in Jepara, but may also be adopted for similar industries throughout Indonesia and the world, and potentially improve many people’s economies and livelihoods.Keywords: wood-based industry, furniture, small-scale, social network, institution

  4. Harnessing microbial gene pools to remediate persistent organic pollutants using genetically modified plants--a viable technology?

    Science.gov (United States)

    Rylott, Elizabeth L; Johnston, Emily J; Bruce, Neil C

    2015-11-01

    It has been 14 years since the international community came together to legislate the Stockholm Convention on Persistent Organic Pollutants (POPs), restricting the production and use of specific chemicals that were found to be environmentally stable, often bioaccumulating, with long-term toxic effects. Efforts are continuing to remove these pollutants from the environment. While incineration and chemical treatment can be successful, these methods require the removal of tonnes of soil, at high cost, and are damaging to soil structure and microbial communities. The engineering of plants for in situ POP remediation has had highly promising results, and could be a more environmentally-friendly alternative. This review discusses the characterization of POP-degrading bacterial pathways, and how the genes responsible have been harnessed using genetic modification (GM) to introduce these same abilities into plants. Recent advances in multi-gene cloning, genome editing technologies and expression in monocot species are accelerating progress with remediation-applicable species. Examples include plants developed to degrade 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), trichloroethylene (TCE), and polychlorinated biphenyls (PCBs). However, the costs and timescales needed to gain regulatory approval, along with continued public opposition, are considerable. The benefits and challenges in this rapidly developing and promising field are discussed. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  5. Harnessing mode-selective nonlinear optics for on-chip multi-channel all-optical signal processing

    Directory of Open Access Journals (Sweden)

    Ming Ma

    2016-11-01

    Full Text Available All-optical signal processing based on nonlinear optical effects allows for the realization of important functions in telecommunications including wavelength conversion, optical multiplexing/demultiplexing, Fourier transformation, and regeneration, amongst others, on ultrafast time scales to support high data rate transmission. In integrated photonic subsystems, the majority of all-optical signal processing systems demonstrated to date typically process only a single channel at a time or perform a single processing function, which imposes a serious limitation on the functionality of integrated solutions. Here, we demonstrate how nonlinear optical effects can be harnessed in a mode-selective manner to perform simultaneous multi-channel (two and multi-functional optical signal processing (i.e., regenerative wavelength conversion in an integrated silicon photonic device. This approach, which can be scaled to a higher number of channels, opens up a new degree of freedom for performing a broad range of multi-channel nonlinear optical signal processing functions using a single integrated photonic device.

  6. Kobuviral Non-structural 3A Proteins Act as Molecular Harnesses to Hijack the Host ACBD3 Protein.

    Science.gov (United States)

    Klima, Martin; Chalupska, Dominika; Różycki, Bartosz; Humpolickova, Jana; Rezabkova, Lenka; Silhan, Jan; Baumlova, Adriana; Dubankova, Anna; Boura, Evzen

    2017-02-07

    Picornaviruses are small positive-sense single-stranded RNA viruses that include many important human pathogens. Within the host cell, they replicate at specific replication sites called replication organelles. To create this membrane platform, they hijack several host factors including the acyl-CoA-binding domain-containing protein-3 (ACBD3). Here, we present a structural characterization of the molecular complexes formed by the non-structural 3A proteins from two species of the Kobuvirus genus of the Picornaviridae family and the 3A-binding domain of the host ACBD3 protein. Specifically, we present a series of crystal structures as well as a molecular dynamics simulation of the 3A:ACBD3 complex at the membrane, which reveals that the viral 3A proteins act as molecular harnesses to enslave the ACBD3 protein leading to its stabilization at target membranes. Our data provide a structural rationale for understanding how these viral-host protein complexes assemble at the atomic level and identify new potential targets for antiviral therapies. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Harnessing the power of communities: Career networking strategies for bioscience PhD students and postdoctoral researchers.

    Science.gov (United States)

    Blackford, Sarah

    2018-02-09

    With an ever more competitive global labour market, coupled with an ever-increasing population of PhD-qualified graduates, the ability to communicate effectively and build strategic connections with others can be advantageous in the job-search process. Whether in pursuit of a tenure-track or non-academic position, many postdoctoral researchers and PhD students will benefit from networking as early as possible to enhance their career propsects. Sometimes viewed cynically as 'using people' or dismissed as 'the old boy network', the ability to make meaningful connections and build relationships can be more valuable than other job-related skills in order to gain entry to, and progress within, many professions.This mini-review highlights the positive influence of networking and how bioscience PhD students and postdoctoral researchers can harness the power of communities to achieve career success. It is argued that those who make connections and promote personal patronage through networking can gain an advantage over their contemporaries. A summary of key theories and research studies that underpin the practice of networking provide credence to these assertions, which are further substantiated with examples pertinent to the academic community. Although primarily focussed on the biosciences, much of the content is applicable to other scientists at a similar career stage. © FEMS 2018. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  8. Harnessing mode-selective nonlinear optics for on-chip multi-channel all-optical signal processing

    Science.gov (United States)

    Ma, Ming; Chen, Lawrence R.

    2016-11-01

    All-optical signal processing based on nonlinear optical effects allows for the realization of important functions in telecommunications including wavelength conversion, optical multiplexing/demultiplexing, Fourier transformation, and regeneration, amongst others, on ultrafast time scales to support high data rate transmission. In integrated photonic subsystems, the majority of all-optical signal processing systems demonstrated to date typically process only a single channel at a time or perform a single processing function, which imposes a serious limitation on the functionality of integrated solutions. Here, we demonstrate how nonlinear optical effects can be harnessed in a mode-selective manner to perform simultaneous multi-channel (two) and multi-functional optical signal processing (i.e., regenerative wavelength conversion) in an integrated silicon photonic device. This approach, which can be scaled to a higher number of channels, opens up a new degree of freedom for performing a broad range of multi-channel nonlinear optical signal processing functions using a single integrated photonic device.

  9. Så galt går det når du ikke har styr på din SEO-partner

    DEFF Research Database (Denmark)

    Ivang, Reimer

    2014-01-01

    Interflora UK lå nummer et på Google på flere søgeord, men fra den ene dag til den anden havde Google fjernet dem. Så spørgsmålet er nu om Interflora UK ikke har styr på, hvad deres SEO partner foretager sig, om de var for grådige eller om de bare er blevet uretfærdig behandlet af Google....

  10. Effekter på insulinsekresjon og endotelfunksjon av DPP-IV-hemmeren sitagliptin (Januvia®) hos pasienter som har utviklet diabetes etter nyretransplantasjon.

    OpenAIRE

    Halden, Thea Anine Strøm

    2012-01-01

    Introduksjon: Nyretransplanterte pasienter er i stor grad utsatt for kardiovaskulære sykdommer som hypertensjon, dyslipidemi, endoteldysfunksjon samt nedsatt glukosetoleranse (IGT)/nyoppstått diabetes etter transplantasjon (NODAT). Disse pasientene har en høyere risiko for prematur kardiovaskulær sykdom og død enn den generelle populasjonen. Behandling av diabetes i nyretransplanterte pasienter samt pasienter med nyresvikt representerer en utfordring. Sitagliptin (Januvia®) er en dipeptidylpe...

  11. A comparative evaluation of methicillin-resistant staphylococci isolated from harness racing-horses, breeding mares and riding-horses in Italy.

    Science.gov (United States)

    Mallardo, Karina; Nizza, Sandra; Fiorito, Filomena; Pagnini, Ugo; De Martino, Luisa

    2013-03-01

    To investigate the prevalence of methicillin-resistant staphylococci (MRS) which is a potencial risk factor of transmission between animals and humans in different types of horses (harness racing-horses, breeding mares and riding-horses) and to compare the antimicrobial resistance of the isolates. A total of 191 healthy horses, housed at different locations of the Campania Region (Italy), were included in the study. Nasal swab samples were collected from each nostril of the horses. The mecA gene was detected by a nested PCR technique. Antibiotic susceptibility was tested for each isolate. MRS was isolated from nasal samples of 68/191 (35.6%; 95% CI: 28.9%-42.9%) healthy horses. All isolates were coagulase-negative with the exception of two coagulase-positive MRS strains, identified as Staphylococcus aureus and Staphylococcus pseudintermedius, 2/83 (2.4%; 95% CI: 0.4%-9.2%). Interestingly, both coagulase-positive MRS isolates were from harness racing-horses. These horses also presented a significantly higher positivity for MRS (53.3%; 95% CI: 40.1%-66.1%) than the breeding mares and riding-horses groups. Antibiotic susceptibility testing showed difference between isolates due to different origins except for an almost common high resistance to aminopenicillins, such as ampicillin and amoxicillin. It can be concluded that harness racing-horses may act as a significant reservoir of MRS as compared to breeding mares and riding-horses.

  12. The interstellar formation and spectra of the noble gas, proton-bound HeHHe+, HeHNe+ and HeHAr+ complexes

    Science.gov (United States)

    Stephan, Cody J.; Fortenberry, Ryan C.

    2017-07-01

    The sheer interstellar abundance of helium makes any bound molecules or complexes containing it of potential interest for astrophysical observation. This work utilizes high-level and trusted quantum chemical techniques to predict the rotational, vibrational and rovibrational traits of HeHHe+, HeHNe+ and HeHAr+. The first two are shown to be strongly bound, while HeHAr+ is shown to be more of a van der Waals complex of argonium with a helium atom. In any case, the formation of HeHHe+ through reactions of HeH+ with HeH3+ is exothermic. HeHHe+ exhibits the quintessentially bright proton-shuttle motion present in all proton-bound complexes in the 7.4 micron range making it a possible target for telescopic observation at the mid-/far-Infrared crossover point and a possible tracer for the as-of-yet unobserved helium hydride cation. Furthermore, a similar mode in HeHNe+ can be observed to the blue of this close to 6.9 microns. The brightest mode of HeHAr+ is dimmed due the reduced interaction of the helium atom with the central proton, but this fundamental frequency can be found slightly to the red of the Ar-H stretch in the astrophysically detected argonium cation.

  13. Harnessing data structure for recovery of randomly missing structural vibration responses time history: Sparse representation versus low-rank structure

    Science.gov (United States)

    Yang, Yongchao; Nagarajaiah, Satish

    2016-06-01

    Randomly missing data of structural vibration responses time history often occurs in structural dynamics and health monitoring. For example, structural vibration responses are often corrupted by outliers or erroneous measurements due to sensor malfunction; in wireless sensing platforms, data loss during wireless communication is a common issue. Besides, to alleviate the wireless data sampling or communication burden, certain accounts of data are often discarded during sampling or before transmission. In these and other applications, recovery of the randomly missing structural vibration responses from the available, incomplete data, is essential for system identification and structural health monitoring; it is an ill-posed inverse problem, however. This paper explicitly harnesses the data structure itself-of the structural vibration responses-to address this (inverse) problem. What is relevant is an empirical, but often practically true, observation, that is, typically there are only few modes active in the structural vibration responses; hence a sparse representation (in frequency domain) of the single-channel data vector, or, a low-rank structure (by singular value decomposition) of the multi-channel data matrix. Exploiting such prior knowledge of data structure (intra-channel sparse or inter-channel low-rank), the new theories of ℓ1-minimization sparse recovery and nuclear-norm-minimization low-rank matrix completion enable recovery of the randomly missing or corrupted structural vibration response data. The performance of these two alternatives, in terms of recovery accuracy and computational time under different data missing rates, is investigated on a few structural vibration response data sets-the seismic responses of the super high-rise Canton Tower and the structural health monitoring accelerations of a real large-scale cable-stayed bridge. Encouraging results are obtained and the applicability and limitation of the presented methods are discussed.

  14. Harnessing the Risk-Related Data Supply Chain: An Information Architecture Approach to Enriching Human System Research and Operations Knowledge

    Science.gov (United States)

    Buquo, Lynn; Johnson-Throop, Kathy

    2010-01-01

    NASA's Human Research Program (HRP) and Space Life Sciences Directorate (SLSD), not unlike many NASA organizations today, struggle with the inherent inefficiencies caused by dependencies on heterogeneous data systems and silos of data and information spread across decentralized discipline domains. The capture of operational and research-based data/information (both in-flight and ground-based) in disparate IT systems impedes the extent to which that data/information can be efficiently and securely shared, analyzed, and enriched into knowledge that directly and more rapidly supports HRP's research-focused human system risk mitigation efforts and SLSD s operationally oriented risk management efforts. As a result, an integrated effort is underway to more fully understand and document how specific sets of risk-related data/information are generated and used and in what IT systems that data/information currently resides. By mapping the risk-related data flow from raw data to useable information and knowledge (think of it as the data supply chain), HRP and SLSD are building an information architecture plan to leverage their existing, shared IT infrastructure. In addition, it is important to create a centralized structured tool to represent risks including attributes such as likelihood, consequence, contributing factors, and the evidence supporting the information in all these fields. Representing the risks in this way enables reasoning about the risks, e.g. revisiting a risk assessment when a mitigation strategy is unavailable, updating a risk assessment when new information becomes available, etc. Such a system also provides a concise way to communicate the risks both within the organization as well as with collaborators. Understanding and, hence, harnessing the human system risk-related data supply chain enhances both organizations' abilities to securely collect, integrate, and share data assets that improve human system research and operations.

  15. Harnessing Online Peer Education (HOPE): integrating C-POL and social media to train peer leaders in HIV prevention.

    Science.gov (United States)

    Jaganath, Devan; Gill, Harkiran K; Cohen, Adam Carl; Young, Sean D

    2012-01-01

    Novel methods, such as Internet-based interventions, are needed to combat the spread of HIV. While past initiatives have used the Internet to promote HIV prevention, the growing popularity, decreasing digital divide, and multi-functionality of social networking sites, such as Facebook, make this an ideal time to develop innovative ways to use online social networking sites to scale HIV prevention interventions among high-risk groups. The UCLA Harnessing Online Peer Education study is a longitudinal experimental study to evaluate the feasibility, acceptability, and preliminary effectiveness of using social media for peer-led HIV prevention, specifically among African American and Latino Men who have Sex with Men (MSM). No curriculum currently exists to train peer leaders in delivering culturally aware HIV prevention messages using social media. Training was created that adapted the Community Popular Opinion Leader (C-POL) model, for use on social networking sites. Peer leaders are recruited who represent the target population and have experience with both social media and community outreach. The curriculum contains the following elements: discussion and role playing exercises to integrate basic knowledge of HIV/AIDS, awareness of sociocultural HIV/AIDS issues in the age of technology, and communication methods for training peer leaders in effective, interactive social media-based HIV prevention. Ethical issues related to Facebook and health interventions are integrated throughout the sessions. Training outcomes have been developed for long-term assessment of retention and efficacy. This is the first C-POL curriculum that has been adapted for use on social networking websites. Although this curriculum has been used to target African-American and Latino MSM, it has been created to allow generalization to other high-risk groups.

  16. Biological inspiration in optics and photonics: harnessing nature's light manipulation strategies for multifunctional optical materials (Conference Presentation)

    Science.gov (United States)

    Kolle, Mathias; Sandt, Joseph D.; Nagelberg, Sara N.; Zarzar, Lauren D.; Kreysing, Moritz; Vukusic, Peter

    2016-03-01

    The precise control of light-matter interactions is crucial for the majority of known biological organisms in their struggle to survive. Many species have evolved unique methods to manipulate light in their environment using a variety of physical effects including pigment-induced, spectrally selective absorption or light interference in photonic structures that consist of micro- and nano-periodic material morphologies. In their optical performance, many of the known biological photonic systems are subject to selection criteria not unlike the requirements faced in the development of novel optical technology. For this reason, biological light manipulation strategies provide inspiration for the creation of tunable, stimuli-responsive, adaptive material platforms that will contribute to the development of multifunctional surfaces and innovative optical technology. Biomimetic and bio-inspired approaches for the manufacture of photonic systems rely on self-assembly and bottom-up growth techniques often combined with conventional top-down manufacturing. In this regard, we can benefit in several ways from highly sophisticated material solutions that have convergently evolved in various organisms. We explore design concepts found in biological photonic architectures, seek to understand the mechanisms underlying morphogenesis of bio-optical systems, aim to devise viable manufacturing strategies that can benefit from insight in biological formation processes and the use of established synthetic routines alike, and ultimately strive to realize new photonic materials with tailor-made optical properties. This talk is focused on the identification of biological role model photonic architectures, a brief discussion of recently developed bio-inspired photonic structures, including mechano-sensitive color-tunable photonic fibers and reconfigurable fluid micro-lenses. Potentially, early-stage results in studying and harnessing the structure-forming capabilities of living cells that

  17. Highly sensitive reduced graphene oxide impedance sensor harnessing π-stacking interaction mediated direct deposition of protein probes.

    Science.gov (United States)

    Kim, Kwang Su; Um, Yu Mi; Jang, Ji-Ryang; Choe, Woo-Seok; Yoo, Pil J

    2013-05-01

    Graphene-based electrochemical impedance sensors have recently received much attention due to their outstanding sensing capability and economic viability. In this study, we present a novel means of constructing an impedance sensing platform via harnessing intrinsic π-stacking interactions between probe protein molecules and reduced graphene oxide (RGO) substrate, obviating the need for introducing external chemical groups often required for covalent anchoring of the probes. To achieve this goal, protein molecules used as a probe were denatured to render their hydrophobic residues exposed in order to facilitate their direct π-stacking interactions with the surface of RGO nanosheets. The protein molecules in denatured form, which would otherwise have difficulty in undergoing π-stacking interactions with the RGO surface, were found to uniformly cover the RGO nanosheets at high density, conducive to providing a graphene-based impedance sensing platform capable of detecting a probe-specific analyte at high sensitivity. The proof-of-concept performance of thus-constructed RGO-based impedance sensors was demonstrated via selective detection of biological binding events of antigen-antibody reaction at a femtomolar range. Notably, since the π-stacking interaction can occur on the entire RGO surface, it can desirably exclude a backfill process indispensable for the conventional biosensors to suppress background noise signals. Since the procedure of π-stacking mediated direct deposition of on-purpose denatured protein probes onto the RGO surface is facile and straightforward, the proposed strategy is anticipated to extend its applicability for fabrication of high performance graphene-based bio or chemical sensors.

  18. Harnessing sensor and information/communication technologies to revolutionize how environmental data are collected and integrated to protect public health

    Energy Technology Data Exchange (ETDEWEB)

    MacDonell, Margaret M.; Raymond, Michelle; Chang, Young-Soo [Argonne National Laboratory, Lemont, IL (United States); Armbruster, Walter J. [Farm Foundation, Darien, IL (United States)

    2013-07-01

    Monitoring the levels of pollutants in ambient air has long been the responsibility of environmental agencies, and traditional programs have relied on a relatively small number of fixed stations that are expensive to install and operate. The spatial coverage of pollutant data ranges from limited in many urban areas to very sparse in smaller suburban and rural areas. Increasingly, the latter are being affected by new pollutant sources such as backyard drilling systems for energy development, and concentrated animal feeding operations and biodiesel production facilities on former agricultural lands. Regional measurement stations are not able to inform local communities about the types and concentrations of pollutants in their ambient and indoor air. Meanwhile, epidemiology studies and clinical data continue to indicate a link between air pollutants and adverse health effects, including respiratory and cardiovascular disease. With asthma on the rise and heart disease among the leading killers, the public has become increasingly concerned about knowing what their personal exposure levels are so they can determine appropriate measures to protect their health. To address this long-standing need, the U.S. Environmental Protection Agency (EPA) has embarked upon an innovative program to improve the understanding of air pollution at the community and neighborhood scales. This program harnesses striking advances in sensor technology, mobile applications, and environmental informatics, with citizens playing a key role. The goal is to facilitate the development and widespread use of inexpensive mobile sensors, for widespread collection and integration of air quality data by citizens across the nation (and world), to help guide environmental health protection programs. (orig.)

  19. Har museerne en plan?

    DEFF Research Database (Denmark)

    Kjeldsen, Anna Karina; Bysted-Sandberg, Marie

    2008-01-01

    Hvor langt er de danske museer med at tænke i strategiske baner, når det gælder deres kommuni- kation? Gør de sig tanker om branding og omdøm- me, medtænker de den interne kommunikation i deres kommunikationsplaner og i hvor høj grad afspejles disse strategier i den daglige praksis? Det er nogle ...

  20. Har Gobind Khorana

    Indian Academy of Sciences (India)

    IAS Admin

    organic chemistry. There is an interesting story on how Khorana ended up working for a PhD in organic chemistry. Because his fellowship came from the Ministry of Agriculture of the Government of India,. Khorana was initially slated to work at an Institute in Berkshire,. England, to study insecticides and fungicides. However ...

  1. Har vi en aftale?

    DEFF Research Database (Denmark)

    Knudsen, Hanne

    Skole og familie skal samarbejde mere og bedre. Det er alle enige om. Alligevel går det ikke altid sådan. Forældre bliver ofte skuffede over det, der opleves som skolens manglende lydhørhed.  Og lærere ser forældresamarbejdet som præget af forældrenes manglende engagement, egocentriske fokus på e...

  2. Harnessing natural ventilation benefits.

    Science.gov (United States)

    O'Leary, John

    2013-04-01

    Making sure that a healthcare establishment has a good supply of clean fresh air is an important factor in keeping patients, staff, and visitors, free from the negative effects of CO2 and other contaminants. John O'Leary of Trend Controls, a major international supplier of building energy management solutions (BEMS), examines the growing use of natural ventilation, and the health, energy-saving, and financial benefits, that it offers.

  3. Har du et problem?

    DEFF Research Database (Denmark)

    Knudsen, Sanne

    2009-01-01

    De fleste universitetsstuderende vil i større eller mindre grad opleve at skulle arbejde problemorienteret ellermed andre former for selvstændig konstruktion af vidensproblemer, om ikke andet så når de skal skrive speciale. På trods af at den problemorienterede tilgang kan forstås og udspilles på...

  4. Stiren-Bütadien Kopolimer Katkısının Çimento Harçlarına Etkisi

    Directory of Open Access Journals (Sweden)

    Alper BİDECİ

    2016-01-01

    Full Text Available Beton üretiminde çoğunlukla yeni kuşak kimyasal katkılar kullanılmaktadır. Dağıtma (dispersiyon gücü yüksek olan kimyasal katkıların beton içerisinde belirli oranlarda kullanılması esastır. Kimyasal katkı içeriği uygun kullanılmadığı takdirde, taze ve sertleşmiş beton özellikleri etkilenmektedir. Çalışmada, akışkanlaştırıcı (%1 ilavesi ile Stiren Bütadien Kopolimer (SBR katkısının çimento harçlarına etkisi araştırılmıştır. Bu amaçla, çimento harçlarına ağırlıkça SBR ilavesi (0%SBR (Kontrol, 5%SBR, 10%SBR, 15%SBR ve %100SBR ile elde edilmiş deney numunelerinin fiziksel, kimyasal ve mekanik özellikleri incelenmiştir. Ayrıca, numunelerin SEM-EDS analizleri yapılmıştır. Çalışmanın sonucunda, %5 Stiren Bütadien Kopolimer katkısının çimento harçlarının basınç dayanımına olumlu etkisi olduğu görülmüştür.

  5. som Ungarn har fremsendt giver anledning til kommentarer eller ændringer i den risikovurdering som Danmark har gennemført i forbindelse med tilladelsen til markedsføring af majslinien MON810. " Zea mays (MON810), Indsigelse fra Ungarn vedr. nye oplysninger der påvirker risikovurderingen. Modtaget 20

    DEFF Research Database (Denmark)

    Kjellsson, Gøsta; Strandberg, Morten Tune; Damgaard, Christian

    2005-01-01

    "DMU vurderer at det præsenterede undersøgelsesmateriale fra Ungarn ikke giver nogen videnskabelig velbegrundet formodning om at den ovennævnte MON810-majs udgør en risiko for miljøet. Ungarn har således for nærværende ingen videnskabeligt baseret grund til at forbyde dyrkning og salg af såsæd in...

  6. Further development of the pneumatic method to harness hydropower and its experimental implementation in the State of Maine. Final report, [February 15, 1990--February 14, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Gorlov, A.M.

    1994-03-01

    This report contains conclusive results of the research project entitled ``Further Development of the Pneumatic Method to Harness Hydropower and its Experimental Implementation in the State of Maine`` sponsored by the US Department of Energy (Contract DE-FG02-91ER12113). The results obtained by this research are considerably beyond the original goals anticipated by the contract which were a theoretical study of the method only and its possible applications. In fact, the success of the analytical research program has allowed us to move on to development, construction and testing of a physical model of the hydro-air power converter and, subsequently, to development of a well equipped hydro-pneumatic power laboratory at Northeastern University. Photographs la and 2a show both the laboratory and the model. Good performance of the model proves that the hydro-pneumatic concept holds much promise for development of an ecologically safe and commercially attractive novel approach to harnessing ultra low-head hydropower. As a result, private companies have started to support this new technology, and to invest money in its further development and construction of demonstration power plants (Appendix 1). Visitors at the Northeastern University laboratory often praise this new technique, as is attested by the articles in the Wall Street Journal (Appendix 2) and the Technology Review (Appendix 3).

  7. Solution structure of the NEAT (NEAr Transporter) domain from IsdH/HarA: the human hemoglobin receptor in Staphylococcus aureus.

    Science.gov (United States)

    Pilpa, Rosemarie M; Fadeev, Evgeny A; Villareal, Valerie A; Wong, Melissa L; Phillips, Martin; Clubb, Robert T

    2006-07-07

    During infections the pathogen Staphylococcus aureus procures the essential nutrient iron from its host using iron-regulated surface determinant (Isd) proteins, which scavenge heme bound iron from host hemoproteins. Four Isd proteins are displayed in the cell wall, where they function as receptors for host proteins and heme. Each of the receptors contains one or more copies of a recently discovered domain called NEAT (NEAr Transporter) that has been shown to mediate protein binding. Here we report the three-dimensional solution structure of the NEAT domain from the IsdH/HarA protein, which is the hemoglobin receptor in the Isd system. This is the first structure of a NEAT domain and reveals that they adopt a beta sandwich fold that consists of two five-stranded antiparallel beta sheets. Although unrelated at the primary sequence level, our results indicate that NEAT domains belong to the immunoglobulin superfamily. Binding studies indicate that two IsdH/HarA NEAT domains bind a single molecule of methemoglobin, while the distantly related NEAT domain from the S. aureus IsdC protein binds only heme. A comparison of their primary sequences in light of the new structure is used to predict the hemoglobin and heme binding surfaces on NEAT domains.

  8. Spatio-Temporal Variability of Western Central African Convection from Infrared Observations

    Directory of Open Access Journals (Sweden)

    Derbetini A. Vondou

    2012-08-01

    Full Text Available The present study has used Meteosat infrared brightness temperature images to investigate the regional and interannual variability of Central African cloudiness. Spatial and temporal variability were investigated using half–hourly data from the Meteosat-7 during June–July–August (JJA of 1998–2002. The full domain of study (1.5E–17E, 1N–15N was divided into six regions and statistics in each region were derived. Analysis of the dependence of cloud fraction to the brightness temperature threshold is explored both over land and ocean. Three diurnal cycle regimes (continental, oceanic, and coastal are depicted according to the amplitude and peak time. Over regions of relatively flat terrain, results indicate enhancement of deep convection in the afternoon followed by a gradual decrease in the night. The diurnal cycle of convection is characterised by afternoon and early evening (around 15:00–18:00 LST maxima located mainly downwind of the major mountain chains, and a more rapid nighttime decay. In terms of the harmonic amplitude, the diurnal signal shows significant regional contrast with the strongest manifestation over the Adamaoua Plateau and the weakest near the South Cameroon Plateau. This remarkable spatial dependence is clear evidence of orographic and heterogeneous land-surface impacts on convective development. Oceanic region exhibits weak activity of convective cloudiness with a maximum at noon. It is suggested that daytime heating of the land surface and moist environment may play a role in determining the spatial distribution of cloud fraction. This study further demonstrates the importance of the Cameroon coastline concavity and coastal mountains in regulating regional frequencies of convection and their initialization. The strength of the diurnal cycle of convective activity depends on mountain height, mean flow, coastal geometry.

  9. Salacia hallei, a name for a rare Celastraceae species from western central Africa

    NARCIS (Netherlands)

    Jongkind, C.C.H.

    2006-01-01

    A new species, Salaria hallei (Celastraceae), from Gabon and Angola is described and illustrated. The species is unique by the combination of glabrous leaves with a transverse tertiary venation, a conspicuous pedunculate inflorescence and glabrous flowers with 3-4 mm wide, almost round, petals and 4

  10. «Del det du har og bruk det du får» En kvalitativ undersøkelse om bruk av nettbrett i vurdering for læring

    OpenAIRE

    Overland, Jan-Arve

    2016-01-01

    Master i IKT-støttet læring Formålet med denne undersøkelsen har vært å få fram kunnskap om hvordan nettbrett blir brukt i vurdering for læring på ungdomstrinnet. Fokuset i oppgaven har vært å se på hvordan nettbrett blir brukt i vurdering for læring for å støtte opp om samhandlingen mellom elev og lærer og mellom elevene. Bakgrunnen for studien er det økte fokuset på bruk av nettbrett og vurdering for læring i norsk skole. Bruk av nettbrett i norsk skole har kommet på den politiske dag...

  11. Engelsk som tredjespråk: Har lærere kompetanse til å støtte flerspråklighet?

    Directory of Open Access Journals (Sweden)

    Anne Dahl

    2016-01-01

    Full Text Available Denne artikkelen handler om norske engelsklæreres kompetanse i å arbeide med barn som har et annet morsmål enn norsk, og som lærer engelsk som fremmedspråk. Problemstillingene er "Hva slags utdanning og kunnskap innen flerspråklighet har engelsklærere i Norge?," "I hvilken grad føler engelsklærere i Norge seg forberedt på å undervise i flerkulturelle og flerspråklige klasserom?" og "Hvilken type kunnskap, ferdigheter og ressurser føler de behov for?". Vi presenterer resultater fra en nasjonal spørreundersøkelse hvor i alt 176 engelsklærere deltok. I tillegg presenterer vi resultater fra fokusintervjuer med i alt fire lærere fra to skoler. Resultatene viser at selv om engelsklærerne til en viss grad føler seg forberedt på arbeid med elever som ikke har norsk som morsmål, har svært få av dem utdanning som fokuserer på flerspråklighet. Svarene fra spørreundersøkelsen og fra intervjuene viser at engelsklærerne gjerne vil ha mer kompetanse på dette området. Vi vil derfor understreke betydningen av utdanning i teori og praksis om flerspråklig utvikling og flerkulturell utdanningsteori, og ikke minst betydningen av tilgang til faglig utvikling som fokuserer på flerspråklighet i skolen og i samfunnet for engelsklærere i Norge.Nøkkelord: engelsklærere, kompetanse, språkpedagogisk kunnskap,flerspråklighet, lærerutdanningAbstractThis paper examines the extent to which English teachers in Norway are prepared to work with children whose mother tongue is not Norwegian, and who are acquiring English as a foreign language. The research questions are “What type of education and knowledge in the area of multilingualism do English teachers in Norway have?,” To what extent do English teachers in Norway feel they are prepared to teach in a multicultural and multilingual classroom?,” and “What kinds of knowledge, skills and resources do they feel a need for?” We present the results of a national survey completed by 176

  12. DELAYED EFFECTS OF ACUTE RADIATION EXPOSURE IN A MURINE MODEL OF THE H-ARS: MULTIPLE-ORGAN INJURY CONSEQUENT TO <10 GY TOTAL BODY IRRADIATION

    Science.gov (United States)

    Unthank, Joseph L.; Miller, Steven J.; Quickery, Ariel K.; Ferguson, Ethan L.; Wang, Meijing; Sampson, Carol H.; Chua, Hui Lin; DiStasi, Matthew R.; Feng, Hailin; Fisher, Alexa; Katz, Barry P.; Plett, P. Artur; Sandusky, George E.; Sellamuthu, Rajendran; Vemula, Sasidhar; Cohen, Eric P.; MacVittie, Thomas J.; Orschell, Christie M.

    2015-01-01

    The threat of radiation exposure from warfare or radiation accidents raises the need for appropriate animal models to study the acute and chronic effects of high dose rate radiation exposure. The goal of this study was to assess the late development of fibrosis in multiple organs (kidney, heart, and lung) in survivors of the C57BL/6 mouse model of the hematopoietic-acute radiation syndrome (H-ARS). Separate groups of mice for histological and functional studies were exposed to a single uniform total body dose between 8.53 and 8.72 Gy of gamma radiation from a 137Cs radiation source and studied 1–21 months later. Blood urea nitrogen levels were elevated significantly in the irradiated mice at 9 and 21 mo (from ~22 to 34 ± 3.8 and 69±6.0 mg/dl, p<0.01 vs non-irradiated controls) and correlated with glomerosclerosis (29±1.8% vs 64±9.7% of total glomeruli, p<0.01 vs non-irradiated controls). Glomerular tubularization and hypertrophy and tubular atrophy were also observed at 21 mo post-total body irradiation (TBI). An increase in interstitial, perivascular, pericardial and peri-bronchial fibrosis/collagen deposition was observed from ~9–21 mo post-TBI in kidney, heart and lung of irradiated mice relative to age-matched controls. Echocardiography suggested decreased ventricular volumes with a compensatory increase in left ventricular ejection fraction. The results indicate that significant delayed effects of acute radiation exposure occur in kidney, heart, and lung in survivors of the murine H-ARS TBI model which mirrors pathology detected in larger species and humans at higher radiation doses focused on specific organs. PMID:26425910

  13. Multiple Sclerosis and the LIF/IL-6 Axis: Use of Nanotechnology to Harness the Tolerogenic and Reparative Properties of LIF

    Directory of Open Access Journals (Sweden)

    Su M. Metcalfe

    2015-05-01

    Full Text Available Leukaemia inhibitory factor (LIF plays a critical role in “stemness” versus “differentiation”, a property that underpins the core value of LIF as a therapeutic for both the treatment of autoimmune disease and for promoting tissue repair. This value can be realized using nano-engineering technology, where a new generation of tools can, with unprecedented ability, manipulate biological functions. One striking example is the treatment of multiple sclerosis (MS. The underpinning biology is the newly identified LIF/IL-6 axis in T lymphocytes, which can tilt the behaviour between immune tolerance versus immune attack. This LIF/IL-6 axis is ideally suited to nanotherapeutic manipulation, given its inherent mechanistic simplicity of two mutually opposing feed-forward loops that determine either tolerogenic (LIF or inflammatory (IL-6 immunity. Using LIF that is formulated in biodegradable nanoparticles (LIF-NP and targeted to CD4+ T cells, the axis is harnessed towards immune tolerance. This has implications for the treatment of autoimmune diseases, where the clinical burden is immense. It encompasses more than 100 diseases and, in the USA alone, costs more than $100 billion in direct health care costs annually. Other properties of LIF include the promotion of healthy neuro-glial interactions within the central nervous system (CNS, where, in addition to MS, LIF-NP therapy is relevant to inflammatory neurodegenerative diseases that represent a large and increasing need within aging populations. Thirdly, LIF is a reparative growth factor that can maintain genomic plasticity. LIF-NP supports the use of stem cell-based therapies in regenerative medicine plus augment therapeutic benefits within the patient. These core properties of LIF are greatly amplified in value by the advantage of being formulated as nanoparticles, namely (i targeted delivery, (ii exploitation of endogenous regulatory pathways and (iii creation of surrogate micro-stromal niches

  14. To Twitter to Woo: Harnessing the power of social media (SoMe) in nurse education to enhance the student's experience.

    Science.gov (United States)

    Sinclair, Wendy; McLoughlin, Moira; Warne, Tony

    2015-11-01

    This paper explores some of the difficulties, challenges and rewards for student nurses and nurse academics when harnessing social media (SoMe) as part of the overall learning experience. The paper draws upon data in the form of student voices, captured through an online planned Twitter chat. This data analysis provides the basis of a case study on the student experience in practice placements. A planned 1 h Twitter chat took place in June 2013, specifically aimed at student nurses. What transpired was an illuminating debate, eliciting responses from around the globe about learning in practice, mentors, and student support that lasted over 3 h. More importantly, the Twitter chat also included qualified nurses and mentors, listening and responding in real time, offering thoughts and solutions to how support and mentoring could be improved. This was in contrast to how students, locally, currently use a paper based questionnaire to give feedback in isolation. The authenticity of this feedback is often compromised by university link lecturers' who often provide a more sanitised version of this feedback to clinical placement. This paper explores whether it is possible to facilitate a realignment and capture the zeitgeist in order to provide the opportunity for enhancing learning in practice. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Fabrication of ZnFe2O4/TiO2 nanotube array composite to harness the augmented photocurrent density under visible light

    Science.gov (United States)

    Boda, Muzaffar Ahmad; Shah, Mohammad Ashraf

    2018-01-01

    ZnFe2O4 micro crystals were deposited over electrochemically anodized TiO2 nanotube array using cathodic electrode deposition method. TiO2 nanotubes owing to their morphological advantage significantly harness the UV region of solar spectrum. However, the optical response of TiO2 nanotube array in visible region is quite negligible due to large band gap. Bare TiO2 nanotubes show a photocurrent density of 0.18 mAcm-2 on exposing TiO2 nanotube electrode to visible light source. However, on mounting ZnFe2O4 over TiO2 nanotubes, the photocurrent density reaches to 0.52 mAcm-2, which is 3 times the photocurrent density shown by bare TiO2 nanotubes under similar conditions. The appreciable enhancement in photocurrent density is attributed to effective visible light active band gap in the resulting hybrid electrode. Moreover, the suitable band edge positions in individual semiconductors facilitate the smooth charge transfer in the resulting hybrid structure on account of band bending at their interface thereby reduces the recombination rate and charge transfer resistance considerably.

  16. Harnessing benefits of helping others: a randomized controlled trial testing expressive helping to address survivorship problems after hematopoietic stem cell transplant.

    Science.gov (United States)

    Rini, Christine; Austin, Jane; Wu, Lisa M; Winkel, Gary; Valdimarsdottir, Heiddis; Stanton, Annette L; Isola, Luis; Rowley, Scott; Redd, William H

    2014-12-01

    Prior research supports the hypothesis that cancer survivors who help others face treatment experience a range of psychosocial and health-related benefits as a result of peer helping. This study investigates an expressive helping (EH) intervention designed to harness those benefits by targeting survivorship problems among cancer survivors treated with hematopoietic stem cell transplant. EH includes two components: (a) emotionally expressive writing (EW; writing one's deepest thoughts and feelings about the transplant experience in a series of brief, structured writing sessions) followed by (b) peer helping (PH; helping other people prepare for transplant by sharing one's own transplant experiences along with advice and encouragement through a written narrative). EH was compared with neutral writing (NW), EW (without PH), and PH (without EW) in a 4-arm randomized controlled trial in which survivors completed baseline measures, 4 structured writing exercises (with instructions depending on randomization), and postintervention measures including validated measures of general psychological distress, physical symptoms, and health-related quality of life (HRQOL). Among survivors with moderate-severe survivorship problems, EH reduced distress (compared with NW and PH; ps writing benefits transplant survivors with moderate-severe survivorship problems, but only if they have first completed expressive writing.

  17. Når skolens behov blir viktigere enn formell kompetanse: Hvordan veilede nyutdannede lærere til å undervise i skolefag de ikke har?

    Directory of Open Access Journals (Sweden)

    Merete Føinum

    2016-04-01

    Full Text Available Studien undersøker veiledning av nyutdannede lærere ved en norsk ungdomsskole. Artikkelen problematiserer de ekstra krevende arbeidsbetingelsene som disse nye lærerne møtte i sitt første år, da de ble satt til å undervise i skolefag de ikke hadde studert. Forskningsspørsmålet er: Hvordan fremstiller nyutdannede ungdomsskolelærere sine opplevelser med å undervise i skolefag de ikke selv er formelt kvalifisert i, og på hvilke måter kan veiledning bidra med støtte? Artikkelen presenterer utdrag fra veiledningssamtaler som eksemplifiserer to nye læreres fremstilling av eget arbeid med elevvurdering når de mangler formell kvalifikasjon i faget. De nyutdannedes perspektiv, og mentorens, fremheves som et samspill gjennom inter­aksjonsanalyse. Artikkelens teoretiske bidrag er analysebegrepene – «psykologisk-emosjonell mentorstøtte» og «faglig-profesjonell mentorstøtte» – som brukes for å identifisere ulike varianter av mentorstøtte i veiledningssamtaler. Innenfor hovedtypen «faglig-profesjonell mentorstøtte» utdypes distinksjonen videre når det skilles analytisk mellom mentor-bidrag som vektlegger spisset drøfting av skolefag (faglig og mentor-innspill av pedagogisk eller mer generell didaktisk karakter (profesjonell. Dermed bidrar studien til å vise hvordan ulike kvaliteter i faglig-profesjonell lærerveiledning kan gjenkjennes i praksis. Funnene viser hvor avgjørende det er at mentor har kompetanse i det skolefaget det skal veiledes i, såfremt skoler ønsker å tilby nyutdannede lærere spisset veiledning i skolefag. Funnene har implikasjoner for skolelederes/-eieres tilrettelegging av arbeidsforhold og organiseringen av veilednings­støtte for nyutdannede lærere.Nøkkelord: nyutdannede (førsteårslærere, mentor(ing, veiledning, undervisningskompe­tanse, skolefag, ungdomsskolen, lærerutdanningAbstract Research on teachers’ professional development establishes the first year of teaching as a vulnerable phase

  18. Human Behavior and Environmental Sustainability: promoting a pro-environmental behavior by harnessing the social, psychological and physical influences of the built environment

    Science.gov (United States)

    Abusafieh, Shaden; Razem, Maiss

    2017-11-01

    Recently, technological advancements in the sustainable design field have allowed us to reduce the ecological impact of the built environment, to reduce consumption of non-renewable resources, to create healthy environments and in some cases may even rehabilitate the ecosystem. Nevertheless, several studies have been carried out showing that sustainable technology does not automatically lead to environmentally friendly behaviors in its users. Various environmental problems threaten environmental sustainability and many of these problems are rooted in human behavior. Unfortunately, there is a lack in studies which take into consideration the human behavior influences within a sustainable built environment. We believe that the built environment should be used to support human goals and requirements, but at the same time we should consider it as a context in which human values and behaviors are cultivated. This research aimed to help in promoting environmental sustainability by using architectural design in changing relevant human behavior toward an environmentally friendly behavior. In order to achieve this, the research adopted Environment-centered Approach to gain more acute perspective into the relationship between the physical environment and human behavior, focusing on social, psychological and physical influences of the built environment. It appears that environmental psychology's merits have high potential in changing behavior within the built environment. The research provides a systematic approach for selecting, assessing, evaluating the behaviors to be changed and the factors that determine them. Furthermore, this approach helps in choosing the best interventions that could be applied in built environment to encourage such a sustainable behavior. This study tried to construct an agenda for further researches to find particular architectural design elements and strategies that we can harness to develop a pro-environment human behavior.

  19. Harnessing the Bethe free energy.

    Science.gov (United States)

    Bapst, Victor; Coja-Oghlan, Amin

    2016-12-01

    A wide class of problems in combinatorics, computer science and physics can be described along the following lines. There are a large number of variables ranging over a finite domain that interact through constraints that each bind a few variables and either encourage or discourage certain value combinations. Examples include the k-SAT problem or the Ising model. Such models naturally induce a Gibbs measure on the set of assignments, which is characterised by its partition function. The present paper deals with the partition function of problems where the interactions between variables and constraints are induced by a sparse random (hyper)graph. According to physics predictions, a generic recipe called the "replica symmetric cavity method" yields the correct value of the partition function if the underlying model enjoys certain properties [Krzkala et al., PNAS (2007) 10318-10323]. Guided by this conjecture, we prove general sufficient conditions for the success of the cavity method. The proofs are based on a "regularity lemma" for probability measures on sets of the form Ωn for a finite Ω and a large n that may be of independent interest. © 2016 Wiley Periodicals, Inc. Random Struct. Alg., 49, 694-741, 2016.

  20. Obamas krige har danske konsekvenser

    DEFF Research Database (Denmark)

    Breitenbauch, Henrik Ø.; Larsen, Esben Salling

    2010-01-01

    Demokratisk kontrol med militæret og det civile embedsværk fordrer, at politikerne efterspørger, tilbydes og vælger mellem reelle valgmuligheder. Stjernejournalisten Bob Woodwards ny bog Obamas krige handler om den amerikanske strategiproces for krigen i Afghanistan. Bogens centrale strid er mellem...... en præsident, der ønskede flere modeller at vælge imellem for indsatsen i Afghanistan, og et militær, der kun gav præsidenten én reel valgmulighed. Obamas krige er dermed relevant for strategiprocessen i dansk forsvarspolitik, og for forholdet mellem politikere og embedsmænd i dansk politik som sådan...

  1. Har du sikret din alderdom?

    DEFF Research Database (Denmark)

    Kiens, Bente; Aagaard, Peter Gjerndrup

    2006-01-01

    Daglig fysisk aktivitet kan betragtes som indbetaling op din personlige helbredspension. Jo mere du sætter ind på kontoen, og jo oftere du gør det, jo større er sandsynligheden for, at du lever længere og får et sundere helbred. Og det er aldrig for sent at starte med indbetalingerne....

  2. Materials in Harnessing Solar Power

    Indian Academy of Sciences (India)

    64

    domestication of solar energy will definitely take place. With the advent of nano- science and technology, it is postulated that nanomaterials ...... material suppliers and marketing fraternity have to be encouraged and closely monitored. The problem of energy is so big that the industry should realize to put aside big margin ...

  3. Arbejdsulykker! Alle har en historie

    DEFF Research Database (Denmark)

    Richter, Anne; Pedersen, Elsebet Frydendal

    in a trade school and in three carpentry companies in relation to five construction sites. The project draws on organizational culture theories of symbolic interactionism and on practice based learning i communities of practice. The methodological approach is primarily ethnographic. Four different cultures...

  4. Solar Radiation: Harnessing the Power

    Science.gov (United States)

    Rowland, Teri; Chambers, Lin; Holzer, Missy; Moore, Susan

    2009-01-01

    My NASA Data (Chambers et al. 2008) is a teaching tool available on NASA's website that offers microsets of real data in an easily accessible, user-friendly format. In this article, the authors describe a lesson plan based on an activity from My NASA Data, in which students explore parts of the United States where they would want to live if they…

  5. Har dansk handyrsproduktion en fremtid?

    DEFF Research Database (Denmark)

    Andersen, Johnny Michael

    2013-01-01

    Lønsomheden i den danske handyrproduktion var lav i 2011. Nettooverskuddet pr. produceret handyr var således negativt for samtlige størrelsesgrupper. Der var dog et positivt dækningsbidrag for de fleste grupper, som indikerer, at det er hensigtsmæssigt at opretholde produktionen på kort sigt, men....... producerede handyr forbliver dog negativt for samtlige størrelsesgrupper....

  6. Klimaforandringerne har allerede ramt os

    DEFF Research Database (Denmark)

    Voigt, Steen

    2009-01-01

    Træernes pollensæson starter i dag flere uger tidligere end for 20 år siden, og mængden af pollen fra fx el og birk er øget markant. Planternes vækstsæson er blevet længere, og det markerer en historisk ændring af naturens tilstand. En ændring, der drives frem af de globale klimaforandringer. Også...

  7. Harnessing neuroplasticity for clinical applications

    Science.gov (United States)

    Sur, Mriganka; Dobkin, Bruce H.; O'Brien, Charles; Sanger, Terence D.; Trojanowski, John Q.; Rumsey, Judith M.; Hicks, Ramona; Cameron, Judy; Chen, Daofen; Chen, Wen G.; Cohen, Leonardo G.; deCharms, Christopher; Duffy, Charles J.; Eden, Guinevere F.; Fetz, Eberhard E.; Filart, Rosemarie; Freund, Michelle; Grant, Steven J.; Haber, Suzanne; Kalivas, Peter W.; Kolb, Bryan; Kramer, Arthur F.; Lynch, Minda; Mayberg, Helen S.; McQuillen, Patrick S.; Nitkin, Ralph; Pascual-Leone, Alvaro; Reuter-Lorenz, Patricia; Schiff, Nicholas; Sharma, Anu; Shekim, Lana; Stryker, Michael; Sullivan, Edith V.; Vinogradov, Sophia

    2011-01-01

    Neuroplasticity can be defined as the ability of the nervous system to respond to intrinsic or extrinsic stimuli by reorganizing its structure, function and connections. Major advances in the understanding of neuroplasticity have to date yielded few established interventions. To advance the translation of neuroplasticity research towards clinical applications, the National Institutes of Health Blueprint for Neuroscience Research sponsored a workshop in 2009. Basic and clinical researchers in disciplines from central nervous system injury/stroke, mental/addictive disorders, paediatric/developmental disorders and neurodegeneration/ageing identified cardinal examples of neuroplasticity, underlying mechanisms, therapeutic implications and common denominators. Promising therapies that may enhance training-induced cognitive and motor learning, such as brain stimulation and neuropharmacological interventions, were identified, along with questions of how best to use this body of information to reduce human disability. Improved understanding of adaptive mechanisms at every level, from molecules to synapses, to networks, to behaviour, can be gained from iterative collaborations between basic and clinical researchers. Lessons can be gleaned from studying fields related to plasticity, such as development, critical periods, learning and response to disease. Improved means of assessing neuroplasticity in humans, including biomarkers for predicting and monitoring treatment response, are needed. Neuroplasticity occurs with many variations, in many forms, and in many contexts. However, common themes in plasticity that emerge across diverse central nervous system conditions include experience dependence, time sensitivity and the importance of motivation and attention. Integration of information across disciplines should enhance opportunities for the translation of neuroplasticity and circuit retraining research into effective clinical therapies. PMID:21482550

  8. Staten har inddraget universiteternes frihed

    DEFF Research Database (Denmark)

    Ingemann, Jan Holm; Christensen, Jens; Madsen, Mogens Ove

    2007-01-01

    I kronikken analyseres den seneste universitetsreform i et historisk perspektiv og i relation til universiteternes principielle rolle. Det konkluderes bl.a., at den klassiske kontrakt om afstand mellem statsmagt og universitet nu de facto er opsagt af den danske stat og frihedslogikken af styring...

  9. Harness the Energy of Collaboration

    Science.gov (United States)

    Lieberman, Ann; Miller, Lynne

    2016-01-01

    As they write about the Learning Communities standard in "Reach the Highest Standard in Professional Learning: Learning Communities," authors Ann Lieberman and Lynne Miller consider why communities have gained widespread attention and support and summarize the established research base about them. They also describe three contexts in…

  10. HARNESSING INTELLECTUAL PROPERTY FOR DEVELOPMENT ...

    African Journals Online (AJOL)

    10332324

    on Limitations and Exceptions for Visually Impaired Persons/Persons with Print. Disabilities was adopted at a ... access to knowledge for learners and the visually impaired.5 Another topical IP issue is the protection of .... used to evaluate the appropriateness of IP protection in South Africa. This framework is based on three ...

  11. Autotootjad vahetavad edetabelikohti / Harli Uljas

    Index Scriptorium Estoniae

    Uljas, Harli

    2005-01-01

    Toyota autode turuosa üha suureneb, samuti suureneb Nissani, Honda ja Hyundai turuosa ja kasum. General Motorsi turuosa väheneb. Aasia autode osakaal ületas USA-s esmakordselt 30%. Lisa: Autofirmade omavahelised sidemed

  12. Lithium: for harnessing renewable energy

    Science.gov (United States)

    Bradley, Dwight; Jaskula, Brian W.

    2014-01-01

    Lithium, which has the chemical symbol Li and an atomic number of 3, is the first metal in the periodic table. Lithium has many uses, the most prominent being in batteries for cell phones, laptops, and electric and hybrid vehicles. Worldwide sources of lithium are broken down by ore-deposit type as follows: closed-basin brines, 58%; pegmatites and related granites, 26%; lithium-enriched clays, 7%; oilfield brines, 3%; geothermal brines, 3%; and lithium-enriched zeolites, 3% (2013 statistics). There are over 39 million tons of lithium resources worldwide. Of this resource, the USGS estimates there to be approximately 13 million tons of current economically recoverable lithium reserves. To help predict where future lithium supplies might be located, USGS scientists study how and where identified resources are concentrated in the Earth’s crust, and they use that knowledge to assess the likelihood that undiscovered resources also exist.

  13. Harnessing science to improve safety.

    Science.gov (United States)

    Baillie, Jonathan

    2011-01-01

    Examining the effectiveness of various wet surface cleaning methods in combating harmful microorganisms in a hospital ward, understanding different healthcare cleaning regimes' impact on reducing slips and trips, evaluating the protection offered by surgical masks against influenza bioaerosols, and independently testing tower crane safety following a number of fatal incidents, are among the broad spectrum of recent projects undertaken by the Buxton-headquartered Health and Safety Laboratory (HSL). As HEJ editor Jonathan Baillie discovered from the organisation's healthcare and patient safety lead, Darren Whitehouse, with around 350 scientists skilled in everything from microbiology to occupational psychology, the range of scientific guidance, expertise, advice, testing, training, and investigation, that the HSL can offer to the healthcare sector is perhaps unrivalled throughout Europe.

  14. Alstom helps harness the Yangtze

    Energy Technology Data Exchange (ETDEWEB)

    Guinivan, D.

    2007-06-15

    The Three Gorges hydropower plant on China's Yangtze River is the world's largest hydropower project. Alstom is supplying nearly half of the turbines and generators for the project. The Three Gorges dam was constructed for several reasons, including regulating the flow of the Yangtze River which was notorious for flooding; rendering the river navigable into the center of China; and, generating electricity. The hydropower plant is expected to create as much electricity as 18 nuclear power plants. It will provide about 10 per cent of the country's energy and replace 40 to 50 million tons of raw coal combustion annually. The width of the Three Gorges is 2.4 km. As such, the greatest challenge facing the project was its sheer size. The runners for the hydro turbine were a massive 10.6 meters in diameter with a height of 5 meters, far larger than any other Alstom had ever produced. They were manufactured in a specially constructed workshop in the south of France and transported by sea to Shanghai. Six riverboats were then used to transport the draft tube elbow to the power plant. It was noted that although the United States has the largest hydropower capacity, China is the fastest growing market, where increased electrical capacity is greatly needed. This article described how the runner of the gravity dam operates. Equipment for the right bank of the Three Gorges was specifically designed to be fish friendly. Orkot plastic bearings were used due to their excellent friction characteristics without the use of grease. The bearings are produced at the Busak and Shamban associated manufacturing company Trelleborg Sealing Systems Rotherham. They are also manufactured for the American market. 4 figs.

  15. Harnessing Theories for Tool Support

    DEFF Research Database (Denmark)

    Liu, Zhiming; Mencl, Vladimir; Ravn, Anders Peter

    2006-01-01

    Software development tools need to support more and more phases of the entire development process, because applications must be developed more correctly and efficiently. The tools therefore need to integrate sophisticated checkers, generators and transformations. A feasible approach to ensure hig...

  16. Harnessing motivation to alleviate neglect

    Directory of Open Access Journals (Sweden)

    Charlotte eRussell

    2013-06-01

    Full Text Available The syndrome of spatial neglect results from the combination of a number of deficits in attention, with patients demonstrating both spatially lateralised and non-lateralised impairments. Previous reports have hinted that there may be a motivational component to neglect and that modulating this might alleviate some of the debilitating symptoms. Additionally, recent work on the effects of reward on attention in healthy participants has revealed improvements across a number of paradigms. As the primary deficit in neglect has been associated with attention, this evidence for reward’s effects is potentially important. However, until very recently there have been few empirical studies addressing this potential therapeutic avenue. Here we review the growing body of evidence that attentional impairments in neglect can be reduced by motivation, for example in the form of preferred music or anticipated monetary reward, and discuss the implications of this for treatments for these patients. Crucially these effects of positive motivation are not observed in all patients with neglect, suggesting that the consequences of motivation may relate to individual lesion anatomy. Given the key role of dopaminergic systems in motivational processes, we suggest that motivational stimulation might act as a surrogate for dopaminergic stimulation. In addition, we consider the relationship between clinical post stroke apathy and lack of response to motivation.

  17. Re-Harnessing the Genie

    Science.gov (United States)

    Lagowski, J. J.

    1996-06-01

    Fifty years ago Vannevar Bush, with the aid of the Federal Government, released the academic research genie. It was argued at the time, and it still may be true, that only academic laboratories could provide the research and trained personnel needed to sustain American's scientific and technological needs. As history has shown, Bush's instinctive distrust of industrial laboratories as a potential training ground was basically correct. In those days, the country's needs were associated with warfare-the end of WWII and the collective hostile activities historically described as the "cold war." Today the country's needs derive from attempts to stay globally competitive. The government's decision to have universities turning out the bulk of the nation's basic research and to use those universities as a venue for developing research talent has created a network of more than 100 research-intensive universities, the output of which is the envy of the world. But, now there is another growing national need-improving the quality of science, mathematics, engineering, and technology (SMET) education throughout the educational system. The genie released 50 years ago, either has to go back into the bottle, or it needs to be re-purposed. The former is highly unlikely, which leaves only the latter as a viable strategy. Indeed, the National Science Foundation, which could be described as the master of the genie, is attempting to do just that. In the past several years, the budget for NSF's suite of "undergraduate" programs has grown to the point where the Foundation currently spends about $180 million on such projects. These programs represent initiatives at the pre-college and undergraduate college levels that are focused on instructional activities (teacher preparation, curriculum development, faculty enhancement, etc.) and research-oriented activities to compliment undergraduate education in a variety of traditional nonresearch environments. These programs are an attempt by NSF to start redressing the imbalance between research and teaching that the Foundation has actively promoted during most of its 50 years of existence. Now, the NSF strategy is to tell the scientists it has supported in the past, and those who will be supported in the future, that what they do in the classroom is as important as what they do in the laboratory; indeed, some would argue it is the most important activity that NSF has to sustain in the current environment. Since NSF is part of the problem, it has an obligation to be part of the solution, which is the essence of a report of an advisory panel. The draft report also has suggestions to universities on how to revise their approach to SMET teaching. It recommends that departments should set goals for what their students should learn, hold faculty members accountable for students' performance, change the academic reward system to incorporate good teaching, and give science faculty members a bigger role in the education of K-12 teachers. The basic problem is that 65% of all undergraduates, including many who will become the nation's precollege teachers, do not attend the more than 100 research intensive institutions that are so heavily supported by NSF's research efforts. In effect, those students have no access to SMET education in a world of growing technical complexity. The report suggests that NSF would do well to redress this imbalance by shifting more of its resources into undergraduate and precollege programs that focus on teaching. This point of view grows out of a 1986 review which centered on how NSF could help science majors. Now, the Foundation is being asked to address the SMET-related problems of all undergraduate students. Clearly, there is danger in attempting to use a system, the relatively meager resources of which have been aimed at about 10% of the population of undergraduates, to serve the entire population. Still, NSF can send a clear message that teaching is important in research-intensive universities. A message that might have a catalytic effect on all institutions. JJL

  18. Vi har sunget, vi har grædt, vi har grint

    DEFF Research Database (Denmark)

    Thurah, Thomas

    Fra omslaget: Benny Andersen og Povl Dissing fortæller her for første gang om deres lange liv med musikken, fra barndommens øvelser med klaver, trommer og trompet hjemme i dagligstuen til samarbejdet med symforniorkestre på vores største scener....

  19. Harnessing Knowledge on Very Important Pharmacogenes CYP2C9 and CYP2C19 Variation for Precision Medicine in Resource-Limited Global Conflict Zones.

    Science.gov (United States)

    Barlas, İbrahim Ömer; Sezgin, Orhan; Dandara, Collet; Türköz, Gözde; Yengel, Emre; Cindi, Zinhle; Ankaralı, Handan; Şardaş, Semra

    2016-10-01

    Pharmacogenomics harnesses the utility of a patient's genome (n = 1) in decisions on which therapeutic drugs and in what amounts should be administered. Often, patients with shared ancestry present with comparable genetic profiles that predict drug response. However, populations are not static, thus, often, population mobility through migration, especially enmasse as is seen for refugees, changes the pharmacogenetic profiles of resultant populations and therefore observed responses to commonly used therapeutic drugs. For example, in the aftermath of the Syrian civil war since 2011, millions have fled their homes to neighboring countries in the Middle East. The growing permanence of refugees and mass migrations is a call to shift our focus in the life sciences community from old models of pharmaceutical innovation. These seismic social changes demand faster decisions for "population-to-population bridging," whereby novel drugs developed in or for particular regions/countries can meet with rational regulatory decisions/approval in world regions impacted by migrant/refugee populations whose profiles are dynamic, such as in the Eastern Mediterranean region at present. Thus, it is important to characterize and report on the prevalence of pharmacogenes that affect commonly used medications and predict if population changes may call for attention to particular differences that may impact health of patients. Thus, we report here on four single-nucleotide polymorphism (SNP) variations in CYP2C9 and CYP2C19 genes among Mersin-Turkish healthy volunteers in the Mersin Province in the Eastern Mediterranean region that is currently hosting a vast number of migrant populations from Syria. Both CYP2C9 and CYP2C19 are very important pharmacogene molecular targets. We compare and report here on the observed SNP genetic variation in our sample with data on 12 world populations from dbSNP and discuss the feasibility of forecasting the pharmacokinetics of drugs utilized by migrant

  20. Petrographic and geochemical analyisis for determination of provenance of the Slovenj Gradec Miocene Basin fill (Western Central Paratethys)

    Science.gov (United States)

    Ivančič, Kristina; Trajanova, Mirka; Skaberne, Dragomir; Šmuc, Andrej

    2017-04-01

    The Slovenj Gradec Basin (SGB) is located in northern Slovenia between eastern margin of the Northern Karavanke and the western Pohorje Mts. Structurally, it belongs to Eastern Alps. It is filled with Miocene clastic sediments. Modal composition of sandstones was determined on thin sections by point-counter and presented with the QFL and QmFLt diagrams. Their geochemical composition was determined by classical method and by Inductively Coupled Plasma-Mass Spectrometry. Based on petrography, sedimentary fill of the SGB consists mostly of lithic grains and quartz, derived from metamorphic and carbonate rocks. Locally, fragments of granitoids occur. Binder consists of carbonate, subordinately quartz cement, and carbonate matrix. Recycled orogen (lithic and transitional recycled) provenance of the grains was determined. Geochemical composition shows that: - Sandstones from the SGB belong to the fields of shale, wacke, litharenite, arkose and subarkose (Pettijohn, 1972). - In the ternary diagram of weathering trends (cf. Nesbitt & Young 1984), the samples group near the CaO+Na2OAl2O3 conjunctive. Calculated minimum CIA (Fedo et al., 1995) is 40.06, indicating that the source rocks were not subjected to considerable weathering. - According to discriminant function (cf. Roser & Korsch, 1988) all samples from SGB originate from quartzose sedimentary rocks. - For determination of tectonic setting of source rocks (Verma & Armstrong-Altrin, 2013) the studied samples plot in the field of collision zone. - In the multidimensional discriminant function diagram for the discrimination of active and passive margin after Verma and Armstrong (2016), the samples plot into the field of passive margin. The data indicate that source rocks of the SGB sedimentary fill were derived from Eastern Alps and Southern Alps. It is suggested that SGB was detached from the Styrian and Mura-Zala Basins in the course of the Pohorje Mts. oblique transpressive uplift during the late Miocene to Pliocene (Trajanova, 2013). Consequently, the area of the wider SGB was still an integral part of the Central Paratethys until late Miocene. References Fedo, C.M., Nesbitt, H.W. & Young, G.M., 1995. Unravelling the effects of potassium metasomatism in sedimentary rocks and paleosols, with implications for paleoweathering conditions and provenance. Geology, 23(10), pp.921-924. Nesbitt, H. W., & Young, G. M., 1984. Prediction of some weathering trends of plutonic and volcanic rocks based on thermodynamic and kinetic considerations. Geochimica et Cosmochimica Acta, 48 (7), 1523-1534. Pettijohn, F.J., Potter, P.E., Siever, R., 1972. Sand and Sandstone, second ed., Springer, New York, heidelberg, Berlin 618, pp. Roser, B.P. & Korsch, R.J., 1988. Provenance signatures of sandstone-mudstonen suites determined using discriminant function of major-element data. Chemical Geology, 67(1-2), pp.119-139. Trajanova, M. 2013: Starost pohorskega magmatizma; nov pogled na nastanek pohorskega tektonskega bloka (Age of the Pohorje Mountains magmatism; new view on the origin of the Pohorje tectonic block). PhD thesis. 183 pp., Ljubljana. Verma, S.P. & Armstrong-Altrin, J.S., 2013. New multi-dimensional diagrams for tectonic discrimination of siliciclastic sediments and their application to Precambrian basins. Chemical Geology, 355, pp.117-133. Verma, S. P., & Armstrong-Altrin, J. S. (2016). Geochemical discrimination of siliciclastic sediments from active and passive margin settings. Sedimentary Geology, 332, 1-12.

  1. Preliminary report on seismic-reflection studies of crustal structure in the western, central, and southern United States

    Science.gov (United States)

    Roller, J.C.; Strozier, O.P.; Jackson, W.H.; Healy, J.H.

    1963-01-01

    During 1963 the U.S. Geological Survey, with the assistance of United ElectroDynamics, Inc., recorded five separate reversed seismic profiles. In addition to these profiles, the U.S. Geological Survey participated in a seismic-calibration program for the DRIBBLE experiment at Tatum Dome, Mississippi, a 20,000-pound shot near Dexter, Missouri, and in a cooperative seismic experiment in the Lake Superior region. This work is a continuation of the program started in 1961; however, the emphasis has shifted from a detailed study of the earth's crust in the western United States to a study of crustal structure in various geologic environments including the Wyoming thrust belt, Colorado Plateau, Central Lowlands, the Gulf Coastal Plain, and the southern part of the Canadian Shield. The U.S. Geological Survey has now completed reversed seismic-refraction profiles in nine different geologic provinces. These data present a promising indication that it may be possible to predict the crustal structure in unexplored areas by considering the regional geologic and physiographic environment. The following Pn velocities have been determined: 8.2 km/sec in the Wyoming thrust belt, 7.9 km/sec in the Colorado Plateau, 8.1 km/sec in the Central Lowlands, and about 8.2 km/sec in the Gulf Coastal Plain. The data from the Lake Superior region have not yet been interpreted.

  2. Hvorfor har danskerne problemer med middellevetiden?

    DEFF Research Database (Denmark)

    Juel, K

    1998-01-01

    The study quantifies the influence of smoking on mortality in Denmark and computes measures for the individual risk. Mortality due to lung cancer among Danish women is now the highest in Europe. Smoking-attributable deaths among men amounted to 3% in 1945, 26% in 1985, and 25% in 1995......; the proportion is lower among women, but is increasing considerably. In 1995 in the age-group 35-69 years such deaths make up the same proportion among men and women. The risk that a 35-year old Dane dies before attaining the age of 70 due to other than smoking-attributable causes has decreased since 1945, most...... significantly among women. Women have experienced a considerable increase in smoking-attributable mortality over the last 20 years, increasing the total risk of a 35 year-old of dying before reaching the age of 70. In 1995 a little over 13,000 of a total of a little less than 63,000 deaths could be attributed...

  3. Harnessing Technology: Transforming Learning and Children's Services

    OpenAIRE

    Laurillard, Diana

    2005-01-01

    Government report; This document is the Department for Education and Skill's first cross-sector e-learning strategy. The strategy focuses on what the technology can do for informing and advising citizens, for supporting children and learners of all ages in their encounters with the system, and for transforming the experience of learning. To make this happen, it identifieds six priorities, to provide: - An integrated online information service for all citizens - Integrated online personal supp...

  4. Parallel Harness for Informatic Stream Hashing

    Energy Technology Data Exchange (ETDEWEB)

    2012-09-11

    PHISH is a lightweight framework which a set of independent processes can use to exchange data as they run on the same desktop machine, on processors of a parallel machine, or on different machines across a network. This enables them to work in a coordinated parallel fashion to perform computations on either streaming, archived, or self-generated data. The PHISH distribution includes a simple, portable library for performing data exchanges in useful patterns either via MPI message-passing or ZMQ sockets. PHISH input scripts are used to describe a data-processing algorithm, and additional tools provided in the PHISH distribution convert the script into a form that can be launched as a parallel job.

  5. Seizing the Moment: Harnessing the Information Technologies

    Science.gov (United States)

    1992-01-01

    acquisition, access, and dissemination of information to almost anyone with an interest (the McLuhan vision). The very nature of the information revolution...Economic Change," Science, Vol. 240, No. 4855, May 20, 1988, p. 977. 6Marshall McLuhan and Quentin Fiore, War and Peace in the Global Village, New York...Mark G. Marshall , "Observing a French Nuclear Weapons Deployment Area," and Donald Vance and William Bumbera, "Imagery Analysis and Installations of

  6. Media Literacy Education: Harnessing the Technological Imaginary

    Science.gov (United States)

    Fry, Katherine G.

    2011-01-01

    An important challenge for media literacy education in the next decade will be to cultivate a commanding voice in the cultural conversation about new and emerging communication media. To really have a stake in the social, economic and educational developments that emerge around new digital media in the U.S. and globally, media literacy educators…

  7. HARNESSING VALUES TO PROMOTE MOTIVATION IN EDUCATION

    Science.gov (United States)

    Harackiewicz, Judith M.; Tibbetts, Yoi; Canning, Elizabeth; Hyde, Janet S.

    2017-01-01

    Purpose We review the interventions that promote motivation in academic contexts, with a focus on two primary questions: How can we motivate students to take more STEM courses? Once in those STEM courses, how can we keep students motivated and promote their academic achievement? Design/methodology/approach We have approached these two motivational questions from several perspectives, examining the theoretical issues with basic laboratory research, conducting longitudinal questionnaire studies in classrooms, and developing interventions implemented in different STEM contexts. Our research is grounded in three theories that we believe are complementary: expectancy-value theory (Eccles & Wigfield, 2002), interest theory (Hidi & Renninger, 2006), and self-affirmation theory (Steele, 1988). As social psychologists, we have focused on motivational theory and used experimental methods, with an emphasis on values – students’ perceptions of the value of academic tasks and students’ personal values that shape their experiences in academic contexts. Findings We review the experimental field studies in high-school science and college psychology classes, in which utility-value interventions promoted interest and performance for high-school students in science classes and for undergraduate students in psychology courses. We also review a randomized intervention in which parents received information about the utility value of math and science for their teens in high school; this intervention led students to take nearly one semester more of science and mathematics, compared with the control group. Finally, we review an experimental study of values affirmation in a college biology course and found that the intervention improved performance and retention for first-generation college students, closing the social-class achievement gap by 50%. We conclude by discussing the mechanisms through which these interventions work. Originality/value These interventions are exciting for their broad applicability in improving students’ academic choices and performance, they are also exciting regarding their potential for contributions to basic science. The combination of laboratory experiments and field experiments is advancing our understanding of the motivational principles and almost certainly will continue to do so. At the same time, interventions may benefit from becoming increasingly targeted at specific motivational processes that are effective with particular groups or in particular contexts. PMID:28890603

  8. HARNESSING VALUES TO PROMOTE MOTIVATION IN EDUCATION.

    Science.gov (United States)

    Harackiewicz, Judith M; Tibbetts, Yoi; Canning, Elizabeth; Hyde, Janet S

    2014-01-01

    We review the interventions that promote motivation in academic contexts, with a focus on two primary questions: How can we motivate students to take more STEM courses? Once in those STEM courses, how can we keep students motivated and promote their academic achievement? We have approached these two motivational questions from several perspectives, examining the theoretical issues with basic laboratory research, conducting longitudinal questionnaire studies in classrooms, and developing interventions implemented in different STEM contexts. Our research is grounded in three theories that we believe are complementary: expectancy-value theory (Eccles & Wigfield, 2002), interest theory (Hidi & Renninger, 2006), and self-affirmation theory (Steele, 1988). As social psychologists, we have focused on motivational theory and used experimental methods, with an emphasis on values - students' perceptions of the value of academic tasks and students' personal values that shape their experiences in academic contexts. We review the experimental field studies in high-school science and college psychology classes, in which utility-value interventions promoted interest and performance for high-school students in science classes and for undergraduate students in psychology courses. We also review a randomized intervention in which parents received information about the utility value of math and science for their teens in high school; this intervention led students to take nearly one semester more of science and mathematics, compared with the control group. Finally, we review an experimental study of values affirmation in a college biology course and found that the intervention improved performance and retention for first-generation college students, closing the social-class achievement gap by 50%. We conclude by discussing the mechanisms through which these interventions work. These interventions are exciting for their broad applicability in improving students' academic choices and performance, they are also exciting regarding their potential for contributions to basic science. The combination of laboratory experiments and field experiments is advancing our understanding of the motivational principles and almost certainly will continue to do so. At the same time, interventions may benefit from becoming increasingly targeted at specific motivational processes that are effective with particular groups or in particular contexts.

  9. Harnessing Nanoparticles for Immunomodulation and Vaccines

    Directory of Open Access Journals (Sweden)

    Ariane C. Gomes

    2017-02-01

    Full Text Available The first successful use of nanoparticles (NPs for vaccination was reported almost 40 years ago with a virus-like particle-based vaccine against Hepatitis B. Since then, the term NP has been expanded to accommodate a large number of novel nano-sized particles engineered from a range of materials. The great interest in NPs is likely not only a result of the two successful vaccines against hepatitis B and Human Papilloma Virus (HPV that use this technology, but also due to the versatility of those small-sized particles, as indicated by the wide range of applications reported so far, ranging from medicinal and cosmetics to purely technical applications. In this review, we will focus on the use of NPs, especially virus-like particles (VLPs, in the field of vaccines and will discuss their employment as vaccines, antigen display platforms, adjuvants and drug delivery systems.

  10. "Jeg har altid haft nemt ved tingene"

    DEFF Research Database (Denmark)

    Rasmussen, Annette; Rasmussen, Palle

    Rapporten analyserer talentundervisningen på 8. og 9. klassetrin i Hjørring Kommune i skoleåret 2006-2007. Der var tale om ekstraundervisning uden for normal skoletid. Det faglige indhold lå inden for fysik, kemi, biologi, matematik og engelsk, og både folkeskolelærere og gymnasielærere medvirkede...

  11. Harnessing the medical humanities for experiential learning.

    Science.gov (United States)

    Singh, Satendra; Barua, Purnima; Dhaliwal, Upreet; Singh, Navjeevan

    2017-01-01

    A month-long workshop on medical humanities was held in the Jorhat Medical College, Assam in September 2015. It employed experiential learning (both online and onsite) using humanities tools, such as the theatre of the oppressed, art, literature, reflective narratives, movies, the history of medicine, graphic medicine, poetry and diversity studies. As a result of the interactions, 28 volunteer participants, comprising students and faculty members, wrote reflective narratives on doctor​-patient relationships, produced a newsletter and a logo for their medical humanities group, and staged cultural performances and forum theatre. The narratives, participants' reflections and feedback received were subjected to qualitative analysis; the workshop was evaluated using Kirkpatrick's model. The participants learned to examine their attitudes and behaviour, communicate with their bodies, and experience respect for diversity. There was an improvement in their understanding of empathy, ethics and professionalism. The workshop achieved level-3 (behaviour) on Kirkpatrick's model, suggesting that such workshops can initiate a change in the ABCDE attributes (attitude, behaviour, communication, diversity, ethics and empathy) of medical professionals.

  12. Harnessing Green IT Principles and Practices

    CERN Document Server

    Murugesan, San

    2012-01-01

    “Ultimately, this is a remarkable book, a practical testimonial, and a comprehensive bibliography rolled into one. It is a single, bright sword cut across the various murky green IT topics. And if my mistakes and lessons learned through the green IT journey are any indication, this book will be used every day by folks interested in greening IT.”— Simon Y. Liu, Ph.D. & Ed.D., Editor-in-Chief, IT Professional Magazine, IEEE Computer Society, Director, U.S. National Agricultural Library This book presents a holistic perspective onGreen IT by discussing its vario

  13. Harnessing modern biotechnology for tropical tuber crop ...

    African Journals Online (AJOL)

    An initial c-DNA library has been constructed in order to develop expressed sequence tags (ESTs) for gene discovery and as a source of additional molecular markers. This paper will review the advances made, discuss the implications for yam genetic improvement and germplasm conservation, and outline the direction for ...

  14. Harnessing the Helminth Secretome for Therapeutic Immunomodulators

    Science.gov (United States)

    Anandarajah, Emmanuela M.; Meissner, Kamila A.; Brattig, Norbert; Liebau, Eva

    2014-01-01

    Helminths are the largest and most complex pathogens to invade and live within the human body. Since they are not able to outpace the immune system by rapid antigen variation or faster cell division or retreat into protective niches not accessible to immune effector mechanisms, their long-term survival depends on influencing and regulating the immune responses away from the mode of action most damaging to them. Immunologists have focused on the excretory and secretory products that are released by the helminths, since they can change the host environment by modulating the immune system. Here we give a brief overview of the helminth-associated immune response and the currently available helminth secretome data. We introduce some major secretome-derived immunomodulatory molecules and describe their potential mode of action. Finally, the applicability of helminth-derived therapeutic proteins in the treatment of allergic and autoimmune inflammatory disease is discussed. PMID:25133189

  15. Gamifying quantum research: harnessing human intuition

    Science.gov (United States)

    Sherson, Jacob

    In the emerging field of citizen science ordinary citizens have already contributed to research in as diverse fields as astronomy, protein and RNA folding, and neuron mapping by playing online games. In the www.scienceathome.org project, we have extended this democratized research to the realm of quantum physics by gamifying a class of challenges related to optimization of gate operations in a quantum computer. The games have been played by more than 150,000 players and perhaps surprisingly we observe that a large fraction of the players outperform state-of-the-art optimization algorithms. With a palette of additional games within cognitive science, behavioral economics, and corporate innovation we investigate the general features of individual and collaborative problem solving to shed additional light on the process of human intuition and innovation and potentially develop novel models of artificial intelligence. We have also developed and tested in classrooms educational games within classical and quantum physics and mathematics at high-school and university level. The games provide individualized learning and enhance motivation for the core curriculum by actively creating links to modern research challenges, see eg. Finally, we have recently launched our new democratic lab: an easily accessible remote interface for our ultra-cold atoms experiment allowing amateur scientists, students, and research institutions world-wide to perform state-of-the-art quantum experimentation. In first tests, nearly a thousand players helped optimize the production of our BEC and discovered novel efficient strategies.

  16. Harnessing Intellectual Property for Development: Some Thoughts ...

    African Journals Online (AJOL)

    Potchefstroom Electronic Law Journal/Potchefstroomse Elektroniese Regsblad. Journal Home · ABOUT · Advanced Search · Current Issue · Archives · Journal Home > Vol 16, No 4 (2013) >. Log in or Register to get access to full text downloads.

  17. Harnessing Intellectual Property for Development: Some Thoughts ...

    African Journals Online (AJOL)

    Such a framework would be the lens through which contested IP issues may be resolved and upon which national IP policy and legislation might be based. The paper begins by highlighting the inherent tensions in IP, which are caused by the various stakeholder interests that this body of law seeks to balance, and by the ...

  18. HARNESSING THE CHEMISTRY OF CO2

    Energy Technology Data Exchange (ETDEWEB)

    Louie, Janis

    2010-05-11

    Our research program is broadly focused on activating CO{sub 2} through the use of organic and organometallic based catalysts. Some of our methods have centered on annulation reactions of unsaturated hydrocarbons (and carbonyl substrates) to provide a diverse array of carbocycles and heterocycles. We use a combination of catalyst discovery and optimization in conjunction with classical physical organic chemistry to elucidate the key mechanistic features of the cycloaddition reactions such that the next big advances in catalyst development can be made. Key to all of our cycloaddition reactions is the use of a sterically hindered, electron donating N heterocyclic carbene (NHC) ligand, namely IPr (or SIPr), in conjunction with a low valent nickel pre-catalyst. The efficacy of this ligand is two-fold: (1) the high {delta}-donating ability of the NHC increases the nucleophilicity of the metal center which thereby facilitates interaction with the electrophilic carbonyl and (2) the steric hindrance prevents an otherwise competitive side reaction involving only the alkyne substrate. Such a system has allowed for the facile cycloaddition to prepare highly functionalized pyrones, pyridones, pyrans, as well as novel carbocycles. Importantly, all reactions proceed under extremely mild conditions (room temperature, atmospheric pressures, and short reaction times), require only catalytic amounts of Ni/NHC and readily available starting materials, and afford annulated products in excellent yields. Our current focus revolves around understanding the fundamental processes that govern these cycloadditions such that the next big advance in the cyclization chemistry of CO{sub 2} can be made. Concurrent to our annulation chemistry is our investigation of the potential for imidazolylidenes to function as thermally-actuated CO{sub 2} sequestering and delivery agents.

  19. Managing and Harnessing Volatile Oil Windfalls

    NARCIS (Netherlands)

    van den Bremer, T.S.; van der Ploeg, F.

    2013-01-01

    Three funds are necessary to manage an oil windfall: intergenerational, liquidity, and investment funds. The optimal liquidity fund is bigger if the windfall lasts longer and oil price volatility, prudence, and the GDP share of oil rents are high and productivity growth is low. The paper applies the

  20. Harnessing Quantum Interference in Molecular Dielectric Materials.

    Science.gov (United States)

    Bergfield, Justin P; Heitzer, Henry M; Van Dyck, Colin; Marks, Tobin J; Ratner, Mark A

    2015-06-23

    We investigate the relationship between dielectric response and charge transport in molecule-based materials operating in the quantum coherent regime. We find that quantum interference affects these observables differently, for instance, allowing current passing through certain materials to be reduced by orders of magnitude without affecting dielectric behavior (or band gap). As an example, we utilize ab initio electronic structure theory to calculate conductance and dielectric constants of cross-conjugated anthraquinone (AQ)-based and linearly conjugated anthracene (AC)-based materials. In spite of having nearly equal fundamental gaps, electrode bonding configurations, and molecular dimensions, we find a ∼1.7 order of magnitude (∼50-fold) reduction in the conductance of the AQ-based material relative to the AC-based material, a value in close agreement with recent measurements, while the calculated dielectric constants of both materials are nearly identical. From these findings, we propose two molecular materials in which quantum interference is used to reduce leakage currents across a ∼25 Å monolayer gap with dielectric constants larger than 4.5.

  1. Jaapanlastele teeb muret stress / Harli Uljas

    Index Scriptorium Estoniae

    Uljas, Harli

    2002-01-01

    Jaapani tervishoiuministeeriumi andmetel oli möödunud aastal 143 karoshi juhtumit - kõrgeim tase alates 1987. aastast, mil probleemi esimest korda teadvustati. Karoshi - äkksurm ületöötamise tõttu

  2. Harnessing Psychoanalytical Methods for a Phenomenological Neuroscience

    Directory of Open Access Journals (Sweden)

    Amir eRaz

    2014-04-01

    Full Text Available Analysis may offer valuable methods for bridging the gap between first-person and third-person accounts of the mind. Using both systematic observational approaches and unstructured narrative interactions, psychoanalysts help patients articulate their experience and bring unconscious mental contents into awareness. Similar to seasoned meditators or phenomenologists, individuals who have undergone analysis are experts in discerning and describing their subjective experience, making them ideal neurophenomenology participants. Moreover, analytic techniques may provide a means of guiding untrained experimental participants to greater awareness of their mental continuum, as well as gathering subjective reports about fundamental yet elusive aspects of experience including selfhood, temporality, and inter-subjectivity. Mining psychoanlysis for its methodological innovations would offer a fresh turn for neuropsychoanalysis and cognitive science as a whole – showcasing the integrity of analysis alongside the irreducibility of human experience.

  3. Harnessing research to protect Botswana's wildlife | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Wildlife of all kinds freely cross the borders of Angola, Botswana, Namibia, Zambia, and Zimbabwe, but is the research data needed to protect them as mobile? Monica Morrison, a PhD candidate at Stellenbosch University and a 2014 Research Award recipient, sought to find out if the extensive research on this vital ...

  4. Harnessing Context for Vandalism Detection in Wikipedia

    Directory of Open Access Journals (Sweden)

    Lakshmish Ramaswamy

    2014-05-01

    Full Text Available The importance of collaborative social media (CSM applications such as Wikipedia to modern free societies can hardly be overemphasized. By allowing end users to freely create and edit content, Wikipedia has greatly facilitated democratization of information. However, over the past several years, Wikipedia has also become susceptible to vandalism, which has adversely affected its information quality. Traditional vandalism detection techniques that rely upon simple textual features such as spammy or abusive words have not been very effective in combating sophisticated vandal attacks that do not contain common vandalism markers. In this paper, we propose a context-based vandalism detection framework for Wikipedia. We first propose a contextenhanced finite state model for representing the context evolution ofWikipedia articles. This paper identifies two distinct types of context that are potentially valuable for vandalism detection, namely content-context and contributor-context. The distinguishing powers of these contexts are discussed by providing empirical results. We design two novel metrics for measuring how well the content-context of an incoming edit fits into the topic and the existing content of a Wikipedia article. We outline machine learning-based vandalism identification schemes that utilize these metrics. Our experiments indicate that utilizing context can substantially improve vandalism detection accuracy.

  5. Harnessing Disorder in Compression Based Nanofabrication

    Science.gov (United States)

    Engel, Clifford John

    The future of nanotechnologies depends on the successful development of versatile, low-cost techniques for patterning micro- and nanoarchitectures. While most approaches to nanofabrication have focused primarily on making periodic structures at ever smaller length scales with an ultimate goal of massively scaling their production, I have focused on introducing control into relatively disordered nanofabrication systems. Well-ordered patterns are increasingly unnecessary for a growing range of applications, from anti-biofouling coatings to light trapping to omniphobic surfaces. The ability to manipulate disorder, at will and over multiple length scales, starting with the nanoscale, can open new prospects for textured substrates and unconventional applications. Taking advantage of previously considered defects; I have been able to develop nanofabrication techniques with potential for massive scalability and the incorporation into a wide range of potential application. This thesis first describes the manipulation of the non-Newtonian properties of liquid Ga and Ga alloys to confine the metal and metal alloys in gratings with sub-wavelength periodicities. Through a solid to liquid phase change, I was able to access the superior plasmonic properties of liquid Ga for the generation of surface plasmon polaritons (SPP). The switching contract between solid and liquid Ga confine in the nanogratings allowed for reversible manipulation of SPP properties through heating and cooling around the relatively low melting temperature of Ga (29.8 °C). The remaining chapters focus on the development and characterization of an all polymer wrinkle material system. Wrinkles, spontaneous disordered features that are produced in response to compressive force, are an ideal for a growing number of applications where fine feature control is no longer the main motivation. However the mechanical limitations of many wrinkle systems have restricted the potential applications of wrinkled surfaces. We developed a wrinkle material system that could be both tuned in feature size from as small as 30 nm up 10 ?m while maximizing the wrinkle amplitude at all wavelengths. By charactering the material properties of both the skin and substrate, we were able to generate wrinkle patterns with fine control over periodicity, amplitude, and orientation. The final chapters of this thesis focuses on the transfer of the wrinkle structure into functional materials aimed at manipulating biological adhesion of cells, optical absorption of solar cells, and sensor sensitivity of Raman substrates. The success of these applications was directly relative to the capabilities of our wrinkle system in controlling the surface chemistry, tuning the periodicity, and maximizing the amplitude for each application.

  6. Harnessing Whole Genome Sequencing in Medical Mycology.

    Science.gov (United States)

    Cuomo, Christina A

    2017-01-01

    Comparative genome sequencing studies of human fungal pathogens enable identification of genes and variants associated with virulence and drug resistance. This review describes current approaches, resources, and advances in applying whole genome sequencing to study clinically important fungal pathogens. Genomes for some important fungal pathogens were only recently assembled, revealing gene family expansions in many species and extreme gene loss in one obligate species. The scale and scope of species sequenced is rapidly expanding, leveraging technological advances to assemble and annotate genomes with higher precision. By using iteratively improved reference assemblies or those generated de novo for new species, recent studies have compared the sequence of isolates representing populations or clinical cohorts. Whole genome approaches provide the resolution necessary for comparison of closely related isolates, for example, in the analysis of outbreaks or sampled across time within a single host. Genomic analysis of fungal pathogens has enabled both basic research and diagnostic studies. The increased scale of sequencing can be applied across populations, and new metagenomic methods allow direct analysis of complex samples.

  7. Vi har selv designet naturens love

    DEFF Research Database (Denmark)

    Bentzen, Martin Mose

    2014-01-01

    ForskerZonenNaturlovene er universelt gyldige i de flestes øjne. De gælder altid, uanset hvad vi tænker. Men dette billede står ikke uimodsagt i videnskabsfilosofien, og der er meget, der tyder på, at det ikke er specielt empirisk korrekt...

  8. Discharging test of electric power harness

    OpenAIRE

    Kawakita, Shiro; Takahashi, Masato; Kusawake, Hiroaki; Kuwajima, Saburo; 川北 史朗; 高橋 真人; 艸分 宏晶; 桑島 三郎

    2004-01-01

    The mechanism of electric power failure of a satellite has been researched. There are many reasons of loss of electric power of a satellite. Investigated was the power loss due to the sustained arc between primary power cables. The heat though arc tracking between the hot and return cables by secondary are discharge made them burn out. If the phenomenon were occurred in space, the satellite would suffer great damage.

  9. Danmarks bevægelser har konsekvenser

    DEFF Research Database (Denmark)

    Sørensen, Carlo Sass; Knudsen, Per

    2014-01-01

    Selv få millimeters sætningsforandringer om året kan påvirke faren for oversvømmelserog øge behovet for renovering af kloaknettet. Et forskningsprojekt med deltagelse af bl.a.DTU Space, Geodatastyrelsen og Kystdirektoratet kortlægger nu omfanget af Danmarks bevægelser og udvikler en metode til...

  10. 'Trump' har allerede vundet i Guatemala

    DEFF Research Database (Denmark)

    Gelardi, Maiken; Restrup, Anne Katrine

    2016-01-01

    En karismatisk tv-stjerne uden politisk erfaring og en tidligere førstedame med mange års erfaring havde også hovedrollerne i Guatemalas præsidentvalg. Men problemerne er begyndt at vise sig - for kan man være systemkritiker og præsident på samme tid?......En karismatisk tv-stjerne uden politisk erfaring og en tidligere førstedame med mange års erfaring havde også hovedrollerne i Guatemalas præsidentvalg. Men problemerne er begyndt at vise sig - for kan man være systemkritiker og præsident på samme tid?...

  11. Sårbarhed har ikke CPR nummer

    DEFF Research Database (Denmark)

    Sodemann, Morten

    2016-01-01

    Paradigmet er, at vi skal møde patienten, der hvor patienten er, og på patientens egne præmisser, mens vi empatisk dæmper effekten af patientens sårbarheder. Men samtidig kan vi se, at der er ulighed i sundhed, også indenfor sundhedsvæsenet....

  12. Harnessing the Power of Scientific Data Warehouses

    Directory of Open Access Journals (Sweden)

    Kevin Deeb

    2005-04-01

    Full Text Available Data warehousing architecture should generally protect the confidentiality of data before it can be published, provide sufficient granularity to enable scientists to variously manipulate data, support robust metadata services, and define standardized spatial components. Data can then be transformed into information that would make them readily available in a common format that is easily accessible, fast, and bridges the islands of dispersed information. The benefits of the warehouse can be further enhanced by adding a spatial component so that the data can be brought to life, overlapping layers of information in a format that is easily grasped by management, enabling them to tease out trends in their areas of expertise.

  13. Harnessing natural diversity to probe metabolic pathways.

    Directory of Open Access Journals (Sweden)

    Oliver R Homann

    2005-12-01

    Full Text Available Analyses of cellular processes in the yeast Saccharomyces cerevisiae rely primarily upon a small number of highly domesticated laboratory strains, leaving the extensive natural genetic diversity of the model organism largely unexplored and unexploited. We asked if this diversity could be used to enrich our understanding of basic biological processes. As a test case, we examined a simple trait: the utilization of di/tripeptides as nitrogen sources. The capacity to import small peptides is likely to be under opposing selective pressures (nutrient utilization versus toxin vulnerability and may therefore be sculpted by diverse pathways and strategies. Hitherto, dipeptide utilization in S. cerevisiae was solely ascribed to the activity of a single protein, the Ptr2p transporter. Using high-throughput phenotyping and several genetically diverse strains, we identified previously unknown cellular activities that contribute to this trait. We find that the Dal5p allantoate/ureidosuccinate permease is also capable of facilitating di/tripeptide transport. Moreover, even in the absence of Dal5p and Ptr2p, an additional activity--almost certainly the periplasmic asparaginase II Asp3p--facilitates the utilization of dipeptides with C-terminal asparagine residues by a different strategy. Another, as-yet-unidentified activity enables the utilization of dipeptides with C-terminal arginine residues. The relative contributions of these activities to the utilization of di/tripeptides vary among the strains analyzed, as does the vulnerability of these strains to a toxic dipeptide. Only by sampling the genetic diversity of multiple strains were we able to uncover several previously unrecognized layers of complexity in this metabolic pathway. High-throughput phenotyping facilitates the rapid exploration of the molecular basis of biological complexity, allowing for future detailed investigation of the selective pressures that drive microbial evolution.

  14. Harnessing glycosylation to improve cellulase activity

    Energy Technology Data Exchange (ETDEWEB)

    Beckham, Gregg T.; Dai, Ziyu; Mattews, James F.; Momany, Michelle; Payne, Christina M.; Adney, William S.; Baker, Scott E.; Himmel, Michael E.

    2012-06-11

    Cellulases and hemicellulases are responsible for the turnover of plant cell wall polysaccharides in the biosphere, and thus form the foundation of enzyme engineering efforts in biofuels research. Many of these carbohydrate-active enzymes from filamentous fungi contain both N-linked and O-linked glycosylation, the extent and heterogeneity of which depends on growth conditions, expression host, and the presence of glycan trimming enzymes in the secretome, all of which in turn impacts enzyme activity. As the roles of glycosylation in enzyme function have not been fully elucidated, here we discuss the potential roles of glycosylation on glycoside hydrolase enzyme structure and function after secretion. We posit that glycosylation, instead of hindering cellulase engineering, can be used as an additional tool to enhance enzyme activity, given deeper understanding of its molecular-level role in biomass deconstruction.

  15. Harnessing Glycosylation to Improve Cellulase Activity

    Energy Technology Data Exchange (ETDEWEB)

    Beckham, G. T.; Dai, Z.; Matthews, J. F.; Momany, M.; Payne, C. M.; Adney, W. S.; Baker, S. E.; Himmel, M. E.

    2012-06-01

    Cellulases and hemicellulases are responsible for the turnover of plant cell wall polysaccharides in the biosphere, and thus form the foundation of enzyme engineering efforts in biofuels research. Many of these carbohydrate-active enzymes from filamentous fungi contain both N-linked and O-linked glycosylation, the extent and heterogeneity of which depends on growth conditions, expression host, and the presence of glycan trimming enzymes in the secretome, all of which in turn impact enzyme activity. As the roles of glycosylation in enzyme function have not been fully elucidated, here we discuss the potential roles of glycosylation on glycoside hydrolase enzyme structure and function after secretion. We posit that glycosylation, instead of hindering cellulase engineering, can be used as an additional tool to enhance enzyme activity, given deeper understanding of its molecular-level role in biomass deconstruction.

  16. Harnessing the fiber fuse for sensing applications.

    Science.gov (United States)

    Lin, Guei-Ru; Baiad, Mohamad Diaa; Gagne, Mathieu; Liu, Wen-Fung; Kashyap, Raman

    2014-04-21

    A simple refractive index sensor based on a small section of fiber damaged by the fiber fuse is proposed and demonstrated with a sensitivity of 350.58 nm/refractive index unit (RIU). For comparison, a hetero-core structure fiber sensor composed of a short no-core fiber (NCF) sandwiched between two pieces of single-mode fibers is demonstrated with a sensitivity of 157.29 nm/RIU. The fiber fuse technique can allow mass production of sensors by incorporating small sections of the damaged fiber of any type into each device. We believe this is the first application of the periodic damage tracks in optical fibers formed by the fiber fuse.

  17. Valminud on uuring õpetajaametist Euroopas / Marilin Harring

    Index Scriptorium Estoniae

    Harring, Marilin

    2002-01-01

    Hariduse infovõrgustik Eurydice koostas 30 Euroopa riigi andmestiku põhjal uuringu õpetajaametist Euroopas. Materjal ilmub Eurydice Key Topics seerias pealkirjaga "The teaching profession in Europe : profile, trends and concerns. Key Topics, Volume 3"

  18. Harnessing the Computer in Educational Management.

    Science.gov (United States)

    Clemson, Barry

    1980-01-01

    The proper function of the computer is as a filter to suppress irrelevant data and highlight critical data, to make short-term projections, to display the dynamics of system interactions, and to allow managers and teachers to interact with models of the system. Outlines the components of such a system. (Author/IRT)

  19. The Harnessed Atom: Nuclear Energy & Electricity.

    Science.gov (United States)

    Department of Energy, Washington, DC. Nuclear Energy Office.

    This document is part of a nuclear energy curriculum designed for grades six through eight. The complete kit includes a written text, review exercises, activities for the students, and a teachers guide. The 19 lessons in the curriculum are divided into four units including: (1) "Energy and Electricity"; (2) "Understanding Atoms and Radiation"; (3)…

  20. Harnessing the Power of Teacher Networks

    Science.gov (United States)

    Farley-Ripple, Elizabeth N.; Buttram, Joan L.

    2013-01-01

    Teacher networks are an important lever for helping schools make change. In order to take advantage of teacher networks, principals must map the existing networks in their schools, identifying teachers and others who serve as experts or advice givers, brokers, and advice seekers. Once these are known, principals can decide on a strategy for…

  1. Harnessing the Power of Wind Technology

    Science.gov (United States)

    Dotson, Tawny M.

    2009-01-01

    "Where the wind comes sweepin' down the plain" is more than just a song lyric for Oklahoma's career and technical education community. It's the acknowledgement of an untapped natural resource that has the potential to translate into both energy independence for the country and jobs for the state. Statewide, technology center instructors…

  2. Safety Harness For Work Under Suspended Load

    Science.gov (United States)

    Sunoo, Su Young

    1994-01-01

    Safety device protects worker under suspended engine or other heavy load. Mechanically linked with load so if load should fall, worker yanked safely away. Worker wears chest-plate vest with straps crossing eye on back. Lower safety cable connected to eye extends horizontally away from worker to nearby wall, wrapped on pulley and extends upward to motion amplifier or reducer. Safety cables transform any sudden downward motion of overhanging load into rapid sideways motion of worker. Net catches worker, preventing worker from bumping against wall.

  3. Harnessing wind power with sustained policy support

    Energy Technology Data Exchange (ETDEWEB)

    Meera, L. [BITS-Pilani. Dept. of Economics, Hyderabad (India)

    2012-07-01

    The development of wind power in India began in the 1990s, and has significantly increased in the last few years. The ''Indian Wind Turbine Manufacturers Association (IWTMA)'' has played a leading role in promoting wind energy in India. Although a relative newcomer to the wind industry compared with Denmark or the US, a combination of domestic policy support for wind power and the rise of Suzlon (a leading global wind turbine manufacturer) have led India to become the country with the fifth largest installed wind power capacity in the world. Wind power accounts for 6% of India's total installed power capacity, and it generates 1.6% of the country's power. (Author)

  4. Harnessing transcription for bioproduction in cyanobacteria

    DEFF Research Database (Denmark)

    Stensjö, Karin; Vavitsas, Konstantinos; Tyystjärvi, Taina

    2018-01-01

    Sustainable production of biofuels and other valuable compounds is one of our future challenges. One tempting possibility is to use photosynthetic cyanobacteria as production factories. Currently, tools for genetic engineering of cyanobacteria are yet not good enough to exploit the full potential...... of cyanobacteria. A wide variety of expression systems will be required to adjust both the expression of heterologous enzyme(s) and metabolic routes to the best possible balance, allowing the optimal production of a particular substance. In bacteria, transcription, especially the initiation of transcription, has...

  5. Har vi sat retssikkerheden til salg?

    DEFF Research Database (Denmark)

    Olesen, Annette; Hartz, Emily; Gottrup, Rikke

    2014-01-01

    Den offentlige forvaltning er i højere grad end tidligere underlagt økonomisk styring og økonomiske målsætninger. Det skal dokumenteres, hvad borgernes skattepenge bruges til, og der stilles krav om løbende effektivisering. I artiklen diskuteres de mulige indirekte konsekvenser dette økonomiske f...

  6. Harnessing the Potential of Additive Manufacturing

    Science.gov (United States)

    2016-12-01

    technical data and technical data rights (includ- ing software ) needed to support product with nongov- ernmental personnel. 1. The life-cycle...their operations and support revenue stream. Defense AT&L: November-December 2016 34 • Work with contracting and intellectual property (IP) attor...data rights are insufficient to use another contractor. Defense AT&L: November-December 2016 32 As we look at the current state of the AM community

  7. Harnessing sloshing as a passive dampener

    Science.gov (United States)

    Killian, Taylor; Klaus, Robert; Truscott, Tadd

    2011-11-01

    This study investigates the impact dynamics of hollow elastic spheres partially filled with fluid, similar to roller hockey balls. Unlike an empty elastic ball, the fluid mitigates some of the rebound through an impulse driven exchange of energy wherein the fluid is forced into a jet inside the ball. Images gathered through experimentation show that the fluid reacts more quickly to the impact than the ball, which decouples the two masses (fluid and ball), imparts energy to the fluid, and removes rebound energy from the ball. The experimental results are compared to an energy method where energy is transferred from the external motion of the ball, to the internal flow of the fluid. Results suggest that while the internal liquid affects the fluid motion, the rebound characteristics of the ball are uniform for a given amount of fluid. Implications of this work on an analog to the roller hockey ball is a potential use of similar passive dampening systems in sports technology and marine engineering. BYU ORCA.

  8. Harnessing microbial resources for increased agricultural ...

    African Journals Online (AJOL)

    Mo

    depletion, environmental, agricultural, food, forestry and public health concerns and contributions towards poverty eradication and improved livelihoods of the people. ... status of microbial resource utilization and conservation has been recently reviewed ... Food Science and Technology Institute. (FOSRI). Pathogens.

  9. The earliest horse harnessing and milking.

    Science.gov (United States)

    Outram, Alan K; Stear, Natalie A; Bendrey, Robin; Olsen, Sandra; Kasparov, Alexei; Zaibert, Victor; Thorpe, Nick; Evershed, Richard P

    2009-03-06

    Horse domestication revolutionized transport, communications, and warfare in prehistory, yet the identification of early domestication processes has been problematic. Here, we present three independent lines of evidence demonstrating domestication in the Eneolithic Botai Culture of Kazakhstan, dating to about 3500 B.C.E. Metrical analysis of horse metacarpals shows that Botai horses resemble Bronze Age domestic horses rather than Paleolithic wild horses from the same region. Pathological characteristics indicate that some Botai horses were bridled, perhaps ridden. Organic residue analysis, using delta13C and deltaD values of fatty acids, reveals processing of mare's milk and carcass products in ceramics, indicating a developed domestic economy encompassing secondary products.

  10. Hospitalspersonale har forskellige holdninger til indvandrerpatienter

    DEFF Research Database (Denmark)

    Nielsen, Anette Sonne; Krasnik, Allan; Michaelsen, Jette Joost

    2008-01-01

    The study investigates hospital staff's different attitudes and experiences with regard to immigrant patients as a basis for educational initiatives.......The study investigates hospital staff's different attitudes and experiences with regard to immigrant patients as a basis for educational initiatives....

  11. Harnessing Digital Workflows for Conserving Historic Places

    Science.gov (United States)

    Santana Quintero, M.

    2017-05-01

    Recording the physical characteristics of historic structures and landscapes is a cornerstone of preventive maintenance, monitoring and conservation. The information produced by such work assists the decision-making process for property owners, site managers, public officials, and conservators. Rigorous documentation may also serve a broader purpose: over time, it becomes the primary means by which scholars and the public apprehend a site that has since changed radically or disappeared. These records also serve as posterity and monitoring records in the event of catastrophic or gradual loss of the heritage resource.

  12. Tidal power harnessing energy from water currents

    CERN Document Server

    Lyatkher, Victor

    2014-01-01

    As the global supply of conventional energy sources, such as fossil fuels, dwindles and becomes more and more expensive, unconventional and renewable sources of energy, such as power generation from water sources, is becoming more and more important.  Hydropower has been around for decades, but this book suggests new methods that are more cost-effective and less intrusive to the environment for creating power sources from rivers, the tides, and other sources of water.   The energy available from water currents is potentially much greater than society's needs.  Presenting a detailed discussi

  13. Harnessing Endogenous Systems for Cancer Therapy

    DEFF Research Database (Denmark)

    Klauber, Thomas Christopher Bogh

    In the recent decade, two strategies in particular have attracted attention due to the prospect of significantly improving cancer treatment: Gene silencing therapy and immunotherapy. Both strategies work by manipulating endogenous mechanisms and theoretically promise very strong effect on the dis......In the recent decade, two strategies in particular have attracted attention due to the prospect of significantly improving cancer treatment: Gene silencing therapy and immunotherapy. Both strategies work by manipulating endogenous mechanisms and theoretically promise very strong effect...... immunotherapy (Project II). Transfer into the clinic of therapies based on gene silencing by siRNA delivered by synthetic vectors has yet to happen. A major reason is the lack of efficiency in the delivery process, partly due to insufficient understanding of cellular uptake and processing of the si...... to the conventional PEIs. However, lipid conjugation did not sufficiently reduce the inherent toxicity associated with high molecular weight PEI, and lipid conjugation of bPEI did also not change the ability of bPEI to affect lysosomal pH as a function of time. In contrast to gene silencing therapy, cancer...

  14. Harnessing Solute Carrier Transporters for Precision Oncology.

    Science.gov (United States)

    Nyquist, Michael D; Prasad, Bhagwat; Mostaghel, Elahe A

    2017-03-28

    Solute Carrier (SLC) transporters are a large superfamily of transmembrane carriers involved in the regulated transport of metabolites, nutrients, ions and drugs across cellular membranes. A subset of these solute carriers play a significant role in the cellular uptake of many cancer therapeutics, ranging from chemotherapeutics such as antimetabolites, topoisomerase inhibitors, platinum-based drugs and taxanes to targeted therapies such as tyrosine kinase inhibitors. SLC transporters are co-expressed in groups and patterns across normal tissues, suggesting they may comprise a coordinated regulatory circuit serving to mediate normal tissue functions. In cancer however, there are dramatic changes in expression patterns of SLC transporters. This frequently serves to feed the increased metabolic demands of the tumor cell for amino acids, nucleotides and other metabolites, but also presents a therapeutic opportunity, as increased transporter expression may serve to increase intracellular concentrations of substrate drugs. In this review, we examine the regulation of drug transporters in cancer and how this impacts therapy response, and discuss novel approaches to targeting therapies to specific cancers via tumor-specific aberrations in transporter expression. We propose that among the oncogenic changes in SLC transporter expression there exist emergent vulnerabilities that can be exploited therapeutically, extending the application of precision medicine from tumor-specific drug targets to tumor-specific determinants of drug uptake.

  15. Harnessing VLSI System Design with EDA Tools

    CERN Document Server

    Kamat, Rajanish K; Gaikwad, Pawan K; Guhilot, Hansraj

    2012-01-01

    This book explores various dimensions of EDA technologies for achieving different goals in VLSI system design. Although the scope of EDA is very broad and comprises diversified hardware and software tools to accomplish different phases of VLSI system design, such as design, layout, simulation, testability, prototyping and implementation, this book focuses only on demystifying the code, a.k.a. firmware development and its implementation with FPGAs. Since there are a variety of languages for system design, this book covers various issues related to VHDL, Verilog and System C synergized with EDA tools, using a variety of case studies such as testability, verification and power consumption. * Covers aspects of VHDL, Verilog and Handel C in one text; * Enables designers to judge the appropriateness of each EDA tool for relevant applications; * Omits discussion of design platforms and focuses on design case studies; * Uses design case studies from diversified application domains such as network on chip, hospital on...

  16. Harnessing Flexibility from Hot and Cold

    DEFF Research Database (Denmark)

    Kiviluoma, Juha; Heinen, Steve; Qazi, Hassan

    2017-01-01

    As has been often reported, electricity systems with high levels of variable wind and solar power generation would benefit from demand flexibility. What is not as often mentioned is that electrification of the transport and heat sectors could exacerbate the need for flexibility, if they are imple......As has been often reported, electricity systems with high levels of variable wind and solar power generation would benefit from demand flexibility. What is not as often mentioned is that electrification of the transport and heat sectors could exacerbate the need for flexibility...... generic principles and characteristics related to heatsector flexibility and demonstrate its possibilities using specific examples. While we generally use the word heat here, most of the discussions also apply to cool, which, after all, is just another form of temperature difference. A major potential...

  17. Horse-mounted invaders from the Russo-Kazakh steppe or agricultural colonists from western Central Asia? A craniometric investigation of the Bronze Age settlement of Xinjiang.

    Science.gov (United States)

    Hemphill, Brian E; Mallory, J P

    2004-07-01

    Numerous Bronze Age cemeteries in the oases surrounding the Täklamakan Desert of the Tarim Basin in the Xinjiang Uyghur Autonomous Region, western China, have yielded both mummified and skeletal human remains. A dearth of local antecedents, coupled with woolen textiles and the apparent Western physical appearance of the population, raised questions as to where these people came from. Two hypotheses have been offered by archaeologists to account for the origins of Bronze Age populations of the Tarim Basin. These are the "steppe hypothesis" and the "Bactrian oasis hypothesis." Eight craniometric variables from 25 Aeneolithic and Bronze Age samples, comprising 1,353 adults from the Tarim Basin, the Russo-Kazakh steppe, southern China, Central Asia, Iran, and the Indus Valley, are compared to test which, if either, of these hypotheses are supported by the pattern of phenetic affinities possessed by Bronze Age inhabitants of the Tarim Basin. Craniometric differences between samples are compared with Mahalanobis generalized distance (d2), and patterns of phenetic affinity are assessed with two types of cluster analysis (the weighted pair average linkage method and the neighbor-joining method), multidimensional scaling, and principal coordinates analysis. Results obtained by this analysis provide little support for either the steppe hypothesis or the Bactrian oasis hypothesis. Rather, the pattern of phenetic affinities manifested by Bronze Age inhabitants of the Tarim Basin suggests the presence of a population of unknown origin within the Tarim Basin during the early Bronze Age. After 1200 B.C., this population experienced significant gene flow from highland populations of the Pamirs and Ferghana Valley. These highland populations may include those who later became known as the Saka and who may have served as "middlemen" facilitating contacts between East (Tarim Basin, China) and West (Bactria, Uzbekistan) along what later became known as the Great Silk Road. Copyright 2004 Wiley-Liss, Inc.

  18. Neoproterozoic diamictite-bearing sedimentary rocks in the northern Yili Block and their constraints on the Precambrian evolution of microcontinents in the Western Central Asian Orogenic Belt

    Science.gov (United States)

    He, Jingwen; Zhu, Wenbin; Zheng, Bihai; Wu, Hailin; Cui, Xiang; Lu, Yuanzhi

    2015-12-01

    The origin and tectonic setting of Precambrian sequences in the Central Asian Orogenic Belt (CAOB) have been debated due to a lack of high resolution geochronological data. Answering this question is essential for the understanding of the tectonic framework and Precambrian evolution of the blocks within the CAOB. Here we reported LA-ICP-MS detrital zircon U-Pb ages and in-situ Hf isotopic data for Neoproterozoic sedimentary cover in the northern Yili Block, an important component of the CAOB, in order to provide information on possible provenance and regional tectonic evolution. A total of 271 concordant U-Pb zircon ages from Neoproterozoic sedimentary cover in the northern Yili Block define three major age populations of 1900-1400 Ma, 1300-1150 Ma and 700-580 Ma, which are quite different from cratons and microcontinents involved in the CAOB. Although it is not completely consistent with the local basement ages, an autochthonous provenance interpretation is more suitable. Some zircon grains show significant old Hf model ages (TDMC; 3.9-2.4 Ga) and reveal continental crust as old as Paleoarchean probably existed. Continuous Mesoproterozoic zircon age populations exhibit large variations in the εHf(t) ratios, suggesting the long-time involvement of both reworked ancient crust and juvenile material. Similar Mesoproterozoic evolution pattern is identified in many continental terranes involved in the CAOB that surround the Tarim Craton. Based on our analysis and published research, we postulate that the northern Yili Block, together with Chinese Central Tianshan, Kyrgyz North Tianshan and some other microcontinents surrounding the Tarim Craton, once constituted the continental margin of the Tarim Craton in the Mesoproterozoic, formed by long-lived accretionary processes. Most of the late Neoproterozoic zircons exhibit significant positive εHf(t) ratios, suggesting the addition of juvenile crust. It is consistent with the tectonic event related to the East Africa Orogen in the Arabian-Nubian Shield and the northern Tarim Craton, indicating the affinity between them in Gondwana.

  19. Observations on the reproductive cycle, age and growth of the salema, Sarpa salpa (Osteichthyes: Sparidae along the western central coast of Italy

    Directory of Open Access Journals (Sweden)

    Alessandro Criscoli

    2006-03-01

    Full Text Available The sexual maturation and the growth of the salema, Sarpa salpa (Linnaeus, 1758, along the Italian Mediterranean coast (central Italy, were studied in fish (n = 105 killed incidentally by underwater explosions during the construction of Civitavecchia harbour in 1999 and specimens collected with trammel nets (n = 339. This species is characterized by a protandric hermaphroditism and the sex change process occurs between 24 and 31 cm TL corresponding to a wide range of ages (3-7 years. Size at maturity (L50 was 19.5 cm, at which almost all the individuals were males. Two distinct spawning periods were observed: one in spring, from March to May, and the other in autumn, from the end of September to November. During the first year, compensatory growth occurred in the individuals born in the two periods. An annual regular pattern of ring deposition was identified in the otoliths: the translucent ring was laid down during the winter months, while the opaque ring was formed during the summer months. Back-calculated lengths at age were used to estimate the parameters of the Von Bertalanffy growth equation which were: L∞ = 37.27 cm, K = 0.27 year-1 and t0 = -0.53 year. Salema showed isometric growth (b = 3.04; P = 0.84; t = 0.19.

  20. Following spread of fire blight in Western, Central and Southern Europe by molecular differentiation of Erwinia amylovora strains with PFGE analysis.

    Science.gov (United States)

    Jock, Susanne; Donat, Victoria; López, Maria M; Bazzi, Carlo; Geider, Klaus

    2002-02-01

    Fire blight has been detected recently in several areas of northern Spain and north-eastern Italy. To follow spread of the disease within Europe, more than 120 Erwinia amylovora strains isolated from 1957-1900 in England, France, Germany, The Netherlands, Belgium, Poland, Italy and Spain were assayed using pulsed-field gel electrophoresis (PFGE) analysis of genomic DNA after XbaI digestion. Pattern types Pt1 and Pt4 were found for strains from England. Pt1 was also found in central Europe and eastern France, Pt4 in western France. Pt2 appeared first in Egypt, from where strains with this pattern disseminated northwards as far as into the Balkans. Pt3 was typical for northern France and Belgium. Strains from Spain displayed the pattern types Pt3 and Pt4. In Italy, Pt2 was found in the south-eastern areas, Pt3 in the north-eastern areas, and Pt1 was found very recently in orchards adjacent to the Austrian border, together with Pt3. Despite barely controlled trade with fire blight host plants and associated plant products within Europe, the PFGE patterns of the E. amylovora isolates were ordered indicating sequential spread. On the other hand, the appearance of Pt3 in northern Italy and central Spain can be explained by the import of contaminated plants by nurseries.

  1. Anatoliacodium gen. nov. (Halimedaceae, Green algae) from the Ilerdian-Cuisian in the Eskişehir region (Western Central Turkey)

    Science.gov (United States)

    Erdem, Nazire Özgen; Radoicic, Rajka

    2009-08-01

    A new genus Anatoliacodium (Halimedaceae, Green algae) is described from the Ilerdian-Cuisian shallow-water sediments of Eskişehir region, central-western Turkey. These sequences consist of limestones, clayey limestones, sandy limestones and claystones. Anatoliacodium gen. nov. is characterized by erected calcareous segments with well differentiated inner structure: prevailing with large medulla of more or less densely set parallel filaments and cortical zone of prevailing horizontal to subhorizontal cortical filaments, once branching and without constriction. It is supposed that poorly and rarely preserved noncalcareous structures on the skeleton surface could be reproductive structures. The type species of the new genus is Anatoliacodium xinanmui gen. nov. sp. nov. A further new species is also described: Anatoliacodium merici gen. nov. sp. nov. Finally Gymnocodium nummuliticum Pfender, 1966 is emended and transferred to the genus Anatoliacodium.

  2. Whole-genome sequence analyses of Western Central African Pygmy hunter-gatherers reveal a complex demographic history and identify candidate genes under positive natural selection.

    Science.gov (United States)

    Hsieh, PingHsun; Veeramah, Krishna R; Lachance, Joseph; Tishkoff, Sarah A; Wall, Jeffrey D; Hammer, Michael F; Gutenkunst, Ryan N

    2016-03-01

    African Pygmies practicing a mobile hunter-gatherer lifestyle are phenotypically and genetically diverged from other anatomically modern humans, and they likely experienced strong selective pressures due to their unique lifestyle in the Central African rainforest. To identify genomic targets of adaptation, we sequenced the genomes of four Biaka Pygmies from the Central African Republic and jointly analyzed these data with the genome sequences of three Baka Pygmies from Cameroon and nine Yoruba famers. To account for the complex demographic history of these populations that includes both isolation and gene flow, we fit models using the joint allele frequency spectrum and validated them using independent approaches. Our two best-fit models both suggest ancient divergence between the ancestors of the farmers and Pygmies, 90,000 or 150,000 yr ago. We also find that bidirectional asymmetric gene flow is statistically better supported than a single pulse of unidirectional gene flow from farmers to Pygmies, as previously suggested. We then applied complementary statistics to scan the genome for evidence of selective sweeps and polygenic selection. We found that conventional statistical outlier approaches were biased toward identifying candidates in regions of high mutation or low recombination rate. To avoid this bias, we assigned P-values for candidates using whole-genome simulations incorporating demography and variation in both recombination and mutation rates. We found that genes and gene sets involved in muscle development, bone synthesis, immunity, reproduction, cell signaling and development, and energy metabolism are likely to be targets of positive natural selection in Western African Pygmies or their recent ancestors. © 2016 Hsieh et al.; Published by Cold Spring Harbor Laboratory Press.

  3. Ørebetennelser hos barn – "alle har noen, men gutter har flest"

    Directory of Open Access Journals (Sweden)

    Kari J. Kværner

    2009-11-01

    Full Text Available  SAMMENDRAGMellomørebetennelse, eller otitis media, er en infeksjons- eller inflammasjonsprosess i mellomøret somogså rammer de tilgrensende avsnitt av denne delen av øvre luftveier, dvs. tuba auditiva og mastoidcellene,selv om disse sjelden gir manifeste symptomer. OM er nesten alltid sekundært til en oppadstigendeslimhinnepatologi i nesen, epipharynx og tuba auditiva.Kværner KJ. Otitis media in children. Nor J Epidemiol 1999; 9 (2: 123-127. ENGLISH SUMMARYOtitis media refers to an infection or inflammation of the middle ear cavity that also affects the eustachiantube and the mastoid cells. Otitis media is almost always caused by an ascending pathology of theepithelial and subepithelial layers of the middle ear mucoperiostium. This paper firstly describes theclassification and distribution of otitis media. Next, using Norwegian data, host related risk factors forotitis media are discussed, particularly focusing on gender differences.

  4. Väikesed muutused annavad kokku suure / Harli Uljas

    Index Scriptorium Estoniae

    Uljas, Harli

    2006-01-01

    Palgatõusust tingitud muudatuste vajalikkusest ettevõtluses. Kommenteerivad ASi Tarkon tegevjuht Ove Carlsson, PTA Grupp ASi juhatuse esimees Peeter Larin, Deloitte Advisory ASi juhatuse esimees Jari Kukkonen

  5. Harnessing the placebo effect: the need for translational research

    Science.gov (United States)

    Colloca, Luana; Miller, Franklin G.

    2011-01-01

    Laboratory research recently has greatly enhanced the understanding of placebo and nocebo effects by identifying specific neuromodulators and brain areas associated with them. However, little progress has been made in translating this knowledge into improved patient care. Here, we discuss the limitations in our knowledge about placebo (and nocebo) effects and the need for translational research with the aim of guiding physicians in maximizing placebo effects and minimizing nocebo effects in their routine clinical practice. We suggest some strategies for how, when and why interventions to promote beneficial placebo responses might be administered in the clinical setting. PMID:21576150

  6. Harnessing social media for health promotion and behavior change.

    Science.gov (United States)

    Korda, Holly; Itani, Zena

    2013-01-01

    Rapid and innovative advances in participative Internet communications, referred to as "social media," offer opportunities for modifying health behavior. Social media let users choose to be either anonymous or identified. People of all demographics are adopting these technologies whether on their computers or through mobile devices, and they are increasingly using these social media for health-related issues. Although social media have considerable potential as tools for health promotion and education, these media, like traditional health promotion media, require careful application and may not always achieve their desired outcomes. This article summarizes current evidence and understanding of using social media for health promotion. More important, it discusses the need for evaluating the effectiveness of various forms of social media and incorporating outcomes research and theory in the design of health promotion programs for social media.

  7. Harnessing the market: The opportunities and challenges of privatization

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-01-01

    The decision to privatize comes from a policy determination that the Government no longer needs particular assets or no longer needs to be in control of all the means by which products or services are obtained or delivered. Most broadly defined, privatization substitutes, in whole or in part, private market mechanisms for the traditional Government role as employer, financier, owner, operator, and/or regulator of a product or service. This definition admits a wide variety of actions, from innovative contractual arrangements to outright divestiture of activities or assets. But all of these actions share common objectives: to remove the agency from those activities that are not inherently governmental functions or core business lines; to improve the management of remaining activities; to reduce the costs of doing business; and to shift greater performance and financial risk to the private sector. This report by the Privatization Working Group provides an indepth analysis of the major issues that surround privatization within the Department of Energy (DOE). The report divides privatization initiatives at the DOE into three major types: divestiture of functions, contracting out, and asset transfers. It includes the results of a survey of the entire DOE system that identifies more than 200 potential privatization opportunities. The report also includes 13 case studies that explore actual DOE privatization efforts over the past 2 years. Additionally, it summarizes the key legal authorities that govern each of the three types of privatization opportunities in the DOE. The report makes a series of recommendations and outlines accompanying actions that will help the DOE seize the opportunities presented by privatization and confront its challenges.

  8. A unified initiative to harness Earth’s microbiomes

    Energy Technology Data Exchange (ETDEWEB)

    Alivisatos, A Paul; Blaser, M. J.; Brodie, Eoin L.; Chun, Miyoung; Dangl, Jeffrey L.; Donohue, Timothy J.; Dorrestein, Pieter C.; Gilbert, Jack A.; Green, Jessica L.; Jansson, Janet K.; Knight, Rob; Maxon, Mary E.; McFall-Ngai, Margaret J.; Miller, Jeff; Pollard, Katherine S.; Ruby, Edward G.; Taha, Sharif A.

    2015-10-28

    Nearly three billion years ago, photosynthetic cyanobacteria transformed Earth’s atmosphere from oxygen-poor to oxygen-rich, enabling the evolution of complex life (1). Microbes shaped our evolutionary origins and their vast impact continues: they are essential constituents of animals and plants and are the most widespread, abundant, and diverse life forms on our planet. Microbial activities enable life but can also imperil it, through unwelcome effects like greenhouse gas production and disease. With a rapidly growing population, centuries of land use, and a changing climate, our planet faces extraordinary challenges. Given their fundamental roles in agriculture, energy production, and the health of our oceans, forests, and human population, understanding the collective activities of Earth’s microbes has never been more crucial.

  9. Harnessing Cueing Training for Neuroplasticity in Parkinson Disease

    NARCIS (Netherlands)

    van Wegen, E.E.H.; Hirsch, M.A.; Huiskamp, M.; Kwakkel, G.

    2014-01-01

    Despite advances in pharmacologic management, deficits in gait and gait-related activities remain persistent in Parkinson disease (PD), resulting in reduced safety and ADL independence. Alternative rehabilitative allied health approaches to the management of these problems, such as physical therapy

  10. Harnessing International Relations Theory to Security Cooperation Program Design

    Science.gov (United States)

    2012-03-22

    behavior. One of the most famous Liberal theorists is the philosopher Immanuel Kant , whose theory of “Perpetual Peace” centered on a vision where “free...democratic states would retain their sovereignty while working together to avoid war.”17 Kant ‟s vision has repeatedly been channeled into a desire...Interdependence and Liberal Institutionalist thinkers share roots with Grotius and Kant , and believe that there is a larger civil society where interstate

  11. Harnessing the Power of SharePoint for Library Applications

    Science.gov (United States)

    Ennis, Lisa A.; Tims, Randy S.

    2010-01-01

    Back in 2008, the authors were looking for a tool that would replace the library's Outlook folders and much of what the library had stored on shared network drives. So they were mainly looking for something that would hold their documents, allow them to better organize those documents, offer an easy way to search for those documents, and be easy…

  12. Harnessing innovations in libraries and information centres: issues and trends

    OpenAIRE

    Dillip K. Swain

    2009-01-01

    Innovation implies the opening of new ideas, methods, and techniques applied to any organization for transformation of its operations for effective consequences. This paper focuses on the trends of innovations in libraries and information centers and addresses different core facets of library innovations. Moreover, it discusses the need of innovation in libraries, the successful factors of innovation, policy instruments, technological trends and such other related issues highlighting the sign...

  13. Harnessing ICTs to scale-up agricultural innovations | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Agricultural research organizations, governments, and civil society are increasingly looking at how to successfully scale up agriculture and food security innovations to bring more lasting benefits to more people. Information and communication technologies (ICTs) can play an important role in greater uptake of innovations: ...

  14. Glukosetransporter 1-mangelsyndrom har et varieret klinisk billede

    DEFF Research Database (Denmark)

    Larsen, Jan; Stubbings, Vibeke; Møller, Rikke Steensbjerre

    2014-01-01

    Glucose transporter-1 deficiency syndrome (GLUT1-DS) is caused by a decreased function of the glucose transporter GLUT1 protein, which is located in the blood brain barrier. This leads to inadequate glucose levels for brain metabolism and can cause various clinical symptoms including medically...

  15. Harnessing case isolation and ring vaccination to control Ebola.

    Directory of Open Access Journals (Sweden)

    Chad Wells

    2015-05-01

    Full Text Available As a devastating Ebola outbreak in West Africa continues, non-pharmaceutical control measures including contact tracing, quarantine, and case isolation are being implemented. In addition, public health agencies are scaling up efforts to test and deploy candidate vaccines. Given the experimental nature and limited initial supplies of vaccines, a mass vaccination campaign might not be feasible. However, ring vaccination of likely case contacts could provide an effective alternative in distributing the vaccine. To evaluate ring vaccination as a strategy for eliminating Ebola, we developed a pair approximation model of Ebola transmission, parameterized by confirmed incidence data from June 2014 to January 2015 in Liberia and Sierra Leone. Our results suggest that if a combined intervention of case isolation and ring vaccination had been initiated in the early fall of 2014, up to an additional 126 cases in Liberia and 560 cases in Sierra Leone could have been averted beyond case isolation alone. The marginal benefit of ring vaccination is predicted to be greatest in settings where there are more contacts per individual, greater clustering among individuals, when contact tracing has low efficacy or vaccination confers post-exposure protection. In such settings, ring vaccination can avert up to an additional 8% of Ebola cases. Accordingly, ring vaccination is predicted to offer a moderately beneficial supplement to ongoing non-pharmaceutical Ebola control efforts.

  16. Action Plan for Harnessing Science and Technology towards ...

    Indian Academy of Sciences (India)

    ... Lectures · Lecture Workshops · Refresher Courses · Symposia. Home; Fellowship. Fellow Profile. Elected: 1934 Section: Earth & Planetary Sciences. Krishnan, Maharajapuram Sitaram FNA 1962-64. Date of birth: 24 August 1898. Date of death: 24 April 1970. Specialization: Economic Geology, Mineralogy, Petrology.

  17. WEB 2.0 LEARNING PLATFORM:Harnessing Collective Intelligence

    Directory of Open Access Journals (Sweden)

    P. Clint ROGERS

    2007-07-01

    Full Text Available ABSTRACT The rate of technological diffusion and the pace at which technology is altering how and with whom we connect is astounding. Although not at the same pace, theoretical views of learning and teaching are also changing. Whereas much of the initial e-learning simply patterned old models of teaching and learning, the new technological possibilities and realities encourage us to think differently about what is meant by education (Brown, 2000. In this paper, we provide a stepping stone in some of the theoretical background, history, and possibilities for learning systems and platforms in the Web 2.0 era. We share a case study that reflects the experiences of a small university that is moving towards E-Learning 2.0 while simultaneously increasing interoperability by using e-learning standards reflected in the widely-used reference model called SCORM (Sharable Content Object Reference Model. We also highlight the strengths and weaknesses of SCORM in allowing for learning management systems to have a Web 2.0 character.

  18. Web 2.0 Learning Platform: Harnessing Collective Intelligence

    Science.gov (United States)

    Rogers, P. Clint; Liddle, Stephen W.; Chan, Peter; Doxey, Aaron; Isom, Brady

    2007-01-01

    The rate of technological diffusion and the pace at which technology is altering how and with whom we connect is astounding. Although not at the same pace, theoretical views of learning and teaching are also changing. Whereas much of the initial e-learning simply patterned old models of teaching and learning, the new technological possibilities…

  19. Beyond bibliometrics harnessing multidimensional indicators of scholarly impact

    CERN Document Server

    Sugimoto, Cassidy R

    2014-01-01

    Bibliometrics has moved well beyond the mere tracking of bibliographic citations. The web enables new ways to measure scholarly productivity and impact, making available tools and data that can reveal patterns of intellectual activity and impact that were previously invisible: mentions, acknowledgments, endorsements, downloads, recommendations, blog posts, tweets. This book describes recent theoretical and practical advances in metrics-based research, examining a variety of alternative metrics -- or "altmetrics" -- while also considering the ethical and cultural consequences of relying on metrics to assess the quality of scholarship. Once the domain of information scientists and mathematicians, bibliometrics is now a fast-growing, multidisciplinary field that ranges from webometrics to scientometrics to influmetrics. The contributors to Beyond Bibliometrics discuss the changing environment of scholarly publishing, the effects of open access and Web 2.0 on genres of discourse, novel analytic methods, and the e...

  20. Harnessing the soil microbiome for increased drought resistance

    Science.gov (United States)

    Dr. Manter is a Research Soil Scientist in the Soil Management and Sugar Beet Research Unit (SMSBRU) of the USDA-Agricultural Research Service in Fort Collins, Colorado. His research examines soil biology and plant-microbial interactions aimed at optimizing soil health. Research emphasis is on dev...

  1. Harnessing bacteriocin biology as targeted therapy in the GI tract.

    Science.gov (United States)

    Kommineni, Sushma; Kristich, Christopher J; Salzman, Nita H

    2016-11-01

    Recently, our laboratory demonstrated that bacteriocins produced by commensal enterococci provide an advantage in niche maintenance in the highly competitive environment of the gastrointestinal (GI) tract. Bacterial production of bacteriocins is a conserved defense strategy to help establish an ecological niche. Bacteriocin-encoding genes in enterococci are often carried on mobile genetic elements, including conjugative plasmids, enabling the transfer of such traits to other community members in a shared niche. Use of a novel mouse model for enterococcal colonization of the GI tract allowed us to investigate enterococcal dynamics and the role of enterococcal bacteriocins in the mouse GI tract. We examined the role of bacteriocin-21, carried on the pPD1 plasmid, in enterococcal colonization of the gut. We discovered that Enterococcus faecalis (EF) harboring pPD1 effectively colonizes the GI tract by using Bac-21 to eliminate its competition. In our study, we also present evidence for active conjugation in the GI tract, a strategy EF uses to enhance the number of bacteriocin producers in a given niche and eliminate bacteriocin-susceptible populations. Using an engineered strain of EF that is capable of producing Bac-21 but impaired in its conjugation ability, we were able to reduce pre-existing colonization by vancomycin-resistant enterococci in the mouse gut. Thus, our results suggest a novel therapeutic strategy to de-colonize antibiotic-resistant enterococci from the GI tract of patients and thereby prevent the emergence of resistant enterococcal infections that are otherwise difficult, or impossible, to treat.

  2. Harnessing ontology and machine learning for RSO classification.

    Science.gov (United States)

    Liu, Bin; Yao, Li; Han, Dapeng

    2016-01-01

    Classification is an important part of resident space objects (RSOs) identification, which is a main focus of space situational awareness. Owing to the absence of some features caused by the limited and uncertain observations, RSO classification remains a difficult task. In this paper, an ontology for RSO classification named OntoStar is built upon domain knowledge and machine learning rules. Then data describing RSO are represented by OntoStar. A demo shows how an RSO is classified based on OntoStar. It is also shown in the demo that traceable and comprehensible reasons for the classification can be given, hence the classification can be checked and validated. Experiments on WEKA show that ontology-based classification gains a relatively high accuracy and precision for classifying RSOs. When classifying RSOs with imperfect data, ontology-based classification keeps its performances, showing evident advantages over classical machine learning classifiers who either have increases of 5 % at least in FP rate or have decreases of 5 % at least in indexes such as accuracy, precision and recall.

  3. The Memory Stack: New Technologies Harness Talking for Writing.

    Science.gov (United States)

    Gannon, Maureen T.

    In this paper, an elementary school teacher describes her experiences with the Memory Stack--a HyperCard based tool that can accommodate a voice recording, a graphic image, and a written text on the same card--which she designed to help her second and third grade students integrate their oral language fluency into the process of learning how to…

  4. Ülesande lahendamise eest saab miljon dollarit / Harli Uljas

    Index Scriptorium Estoniae

    Uljas, Harli

    2000-01-01

    Maailma tippmatemaatikutele pakutakse seitset miljonit dollarit seitsme raske võrduse lahendamise eest. Clay Mathematics Institute pani probleemi üles oma internetileheküljele ja teatas sellest Pariisis toimunud konverentsil. Princetoni ülikooli matemaatikaprofessori Andrew Wilesi sõnul on need seitse matemaatilist probleemi selle ala kõige suuremad lahendamata väljakutsed

  5. HARNESSING THE CHEMISTRY OF CO{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Louie, Janis

    2012-11-30

    Our research presents several strategies for addressing the challenges of activating CO2. In addition, our cycloaddition chemistry addresses several fundamental issues pertaining to catalysis as it applies to energy conservation. Topics addressed include: DEVELOPMENT OF A CYCLOADDITION CATALYST; INCREASING THE UTILITY OF THE NI CYCLOADDITION CATALYST; UNDERSTANDING THE MECHANISM OF NI-CATALYZED CYCLOADDITION; and METAL-FREE CO{sub 2} ACTIVATION.

  6. Improving the Learning Experience by Harnessing Digital Technology

    Directory of Open Access Journals (Sweden)

    Panagiota Koulouvari R.

    2012-02-01

    Full Text Available The paper will explore how a social media based E-learning 2.0 solution for formal learning (social IS can be implemented, focusing on the technology acceptance process. The paper aims to increase the knowledge on how the acceptance regarding social media based E-learning 2.0 information systems for formal learning can be increased and how the acceptance affects the social learning experience. To achieve this, the paper relies on both a qualitative and quantitative approach and is primarily inductive. The paper concludes that the acceptance cannot be seen as a linear process, as is common practice. Instead, one should see the process of acceptance as interlinked with the experience and external variables in a continuous process that can either ‘spiral’ upwards or downwards. Furthermore, the paper identifies the problem of innovation resistance. The paper then analyzes information gathered from industry experts, practitioners and a live case to find how one can improve acceptance and thereby the social learning experience. Once these variables have been identified the paper presents strategic advice. The paper ends by a discussion of the results, both regarding the impact and contrast to previous research as well as highlighting areas for further research

  7. Harnessing the International Treaty on Plant Genetic Resources for ...

    African Journals Online (AJOL)

    Nekky Umera

    Agriculture is a landmark international agreement for ensuring food security and sustainable agriculture ... policy makers, legal practitioners and managers of plant genetic resources for food and agriculture in these ..... Ex situ collections of other international organizations that sign agreements with the Governing Body are.

  8. Harnessing cell-material interaction to control cell fate: design ...

    Indian Academy of Sciences (India)

    Rajat K Das

    2017-10-26

    Oct 26, 2017 ... advancement in engineered hydrogel materials as such scaffold to control cell fate. Keywords. Extracellular matrix; hydrogel .... tandem and determine the fate of the stem cells (cytoskeletal actin re-organization, gene ..... (encapsulation and on-demand release of therapeutic cells). These examples indicate ...

  9. Providing truly patient-centred care: Harnessing the pragmatic ...

    African Journals Online (AJOL)

    Healthcare professionals in South Africa have to improvise when treating patients who do not speak their language – generally by using ad-hoc interpreters, who may be nurses, refugees, family members, or even children. A number of studies (Cambridge 1999, Meyer et al. 2003, Penn 2007) have found that using ad-hoc ...

  10. Adult Education and Social Sustainability: Harnessing the "Red Queen Effect"

    Science.gov (United States)

    Easton, Peter

    2007-01-01

    In 1973, the evolutionary biologist Leigh Van Valen of the University of Chicago devised what he called the "Red Queen Effect" to describe the growth and development of species. It stipulated that an evolutionary system must continue to develop just to maintain its fitness relative to others evolving in its environment. The literary reference is…

  11. Harnessing Solar Energy for the Production of Clean Fuel

    NARCIS (Netherlands)

    Pandit, A.; Holzwarth, A.; de Groot, H.J.M.

    2008-01-01

    The European Union and its member states are being urged by leading scientists to make a major multi million Euro commitment to solar driven production of environmentally clean electricity, hydrogen and other fuels, as the only sustainable long-term solution for global energy needs. The most

  12. Harnessing Solar Energy Using Photosynthetic and Organic Pigments

    Science.gov (United States)

    Fitzsimons, Toby Ryan

    Fossil fuels are a finite energy resource that must be supplemented or replaced by more stable forms of electrical energy. Solar technology research strives to supplement and provide eventual replacement for fossil fuel technology. This experiment focused on the use of natural pigments as photo-sensitizers in the current generation of solar cells called dye sensitized solar cells (DSSCs). Pigments from purified chlorophyll a, chlorophyll b, chlorophyll a/b, crude spinach (Spinacia oleracea) extract, phycocyanin, and chlorophyllin were used to construct DSSCs and evaluated, along with a control containing no pigment, for solar energy conversion. The anode of the solar cells consisted of titanium dioxide (TiO2) plates soaked in pigment solutions for twenty-four hours. The plates were assembled, along with an electrolyte sandwiched between cells, and a platinum-coated counter plate that functioned as the cathode. A gasket seal was placed between the plates and held together with rubber bands. The DSSCs were each tested for a maximum power (Pmax) point and a resistor was selected that corresponded to the resistance at that point. The cells were randomly placed into a power block assembly located in an environmental chamber with lighting that provided an average of 27,590 lumens at the surface of DSSCs. With appropriate resistors in place, the cells were subjected to twelve-hour days and twelve-hour nights for ten days, and measurements were recorded every ten minutes. Data were collected to obtain values for voltage in millivolts (mV), current in microamps (microA), and power in microwatts (microW), as well as beginning and ending efficiencies in converting light to usable energy. Voltages were substantially higher during the day than at night for all pigments, except for the control, indicating that the pigments functioned as DSSCs. Hence, only daytime values were used for data analysis. Voltage during the ten-day experiment ranged from 3.99 to 274 mV; current ranged from 0.0180 to 41.9 microA, and power ranged from 0.00 to 11.3 microW. Chlorophyllin had the highest peak and least voltage (274 and 161 mV), highest peak and least current (41.9 and 21.8 microA), and highest peak and least power (11.3 and 4.84 microW). The ranking of the pigments for peak voltage was: Chlorophyllin = Crude Extract ≥ Chlorophyll a = Chlorophyll a/b ≥ Phycocyanin = Chlorophyll b > Control. The ranking for least voltage was: Chlorophyllin > Phycocyanin ≥ Chlorophyll a/b ≥ Crude Extract ≥ Chlorophyll b ≥ Chlorophyll a ≥ Control. Ranking for peak and least values were similar for current and power. Solar energy conversion (efficiency in converting light energy to usable energy in watts per square meter) for all treatments ranged from 0.000595 to 0.0217% at the beginning of the experiment, and was highest in cells constructed with chlorophyllin. Based on rankings from peak and ending voltage values, as well as other measurements, it was concluded that DSSCs constructed with chlorophyllin performed the best and lasted the longest as photo-sensitizers, compared to other pigments used in this investigation. The DSSCs constructed with crude extract performed almost as well as those constructed with chlorophyllin at the beginning of the experiment, but degradation of this naturally-made pigment may have prevented these cells from sustaining solar energy conversion for more than a few days. Other pigments demonstrated conversion values higher than those of control DSSCs which contained no pigments. The results from this project provide evidence that DSSCs can produce useable energy. More research is needed to enhance and prolong the efficiency of DSSCs in solar energy conversion.

  13. Understanding and Harnessing the Power of Ideas, Persuasion, and Trust

    Science.gov (United States)

    2013-09-17

    Science, National Tsing Hua University Political Sociology Turkey Nora Fisher Onar Ahçeşehir U, Political Science and International Relations...Also, Director, SouthEast Eur Stud at Oxford branch in Istanbul Political Sociology Sing Cheong Siew Ann National Technical University (NTU

  14. Harnessing the Wind: The Art of Teaching Modern Dance.

    Science.gov (United States)

    Erkert, Jan

    This book provides theoretical knowledge, practical tips, and inspiration to help prepare the next generation of dancers and meet the demands of contemporary dance. It teaches the reader to set strategies and reasonable goals; use rituals to facilitate centering; safely incorporate conditioning principles; understand the interplay between gravity…

  15. Harnessing context sensing to develop a mobile intervention for depression.

    Science.gov (United States)

    Burns, Michelle Nicole; Begale, Mark; Duffecy, Jennifer; Gergle, Darren; Karr, Chris J; Giangrande, Emily; Mohr, David C

    2011-08-12

    Mobile phone sensors can be used to develop context-aware systems that automatically detect when patients require assistance. Mobile phones can also provide ecological momentary interventions that deliver tailored assistance during problematic situations. However, such approaches have not yet been used to treat major depressive disorder. The purpose of this study was to investigate the technical feasibility, functional reliability, and patient satisfaction with Mobilyze!, a mobile phone- and Internet-based intervention including ecological momentary intervention and context sensing. We developed a mobile phone application and supporting architecture, in which machine learning models (ie, learners) predicted patients' mood, emotions, cognitive/motivational states, activities, environmental context, and social context based on at least 38 concurrent phone sensor values (eg, global positioning system, ambient light, recent calls). The website included feedback graphs illustrating correlations between patients' self-reported states, as well as didactics and tools teaching patients behavioral activation concepts. Brief telephone calls and emails with a clinician were used to promote adherence. We enrolled 8 adults with major depressive disorder in a single-arm pilot study to receive Mobilyze! and complete clinical assessments for 8 weeks. Promising accuracy rates (60% to 91%) were achieved by learners predicting categorical contextual states (eg, location). For states rated on scales (eg, mood), predictive capability was poor. Participants were satisfied with the phone application and improved significantly on self-reported depressive symptoms (beta(week) = -.82, P interview measures of depressive symptoms (beta(week) = -.81, P technical functionality, data mining, and software development process are discussed. Clinicaltrials.gov NCT01107041; http://clinicaltrials.gov/ct2/show/NCT01107041 (Archived by WebCite at http://www.webcitation.org/60CVjPH0n).

  16. Harnessing information technology to innovate in primary care.

    Science.gov (United States)

    Jiwa, Moyez; McManus, Alexander; Dadich, Ann; White, James; Rieck, Alison; Razmi, Shohreh

    2013-01-01

    The health sector's capacity to meet the changing needs of patients is being questioned. This has significant implications for patients, carers, health services and those who hold the public purse. It is therefore important to bolster its capacity to serve a greater proportion of people in need of health care, opportunities for which might be facilitated by information technology (IT). To identify strategies to bolster the capacity of the primary care sector to deploy and innovate with IT. Three discussion groups comprising clinicians, regulatory agents, innovators and academics from each Australian state. Themes discussed included: (1) health problems that can be readily solved by IT, (2) clinician engagement with IT, (3) experiences with IT implementation, (4) engagement with hard-to-reach groups, and (5) social media use. Although participants were aware of the issues surrounding the use of IT, including limited evidence and reduced data integrity, they were equally aware of the opportunities afforded by IT. With appropriate support, they indicated that IT could help to innovate and reinvigorate the primary care sector. This could be demonstrated via research, initiatives that improve governance arrangements (within and beyond the primary care sector), programmes that enhance care delivery and consumer empowerment initiatives. Clinicians are rarely included as part of teams developing innovations, and technology is not always tailored for clinical practice or tested on clinical outcomes. Technical and access issues continue to hamper dissemination of innovation. The need for leadership in developing IT healthcare solutions remains paramount, with the organisation best able to negotiate with the key stakeholders at the helm.

  17. Ethnophytotechnology: Harnessing the Power of Ethnobotany with Biotechnology.

    Science.gov (United States)

    de la Parra, John; Quave, Cassandra L

    2017-09-01

    Ethnobotany (the scientific study of traditional plant knowledge) has aided the discovery of important medicines. However, as single-molecule drugs or synergistic mixtures, these remedies have faced obstacles in production and analysis. Now, advances in bioreactor technology, metabolic engineering, and analytical instrumentation are improving the production, manipulation, and scientific understanding of such remedies. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Reverse pharmacognosy: another way to harness the generosity of nature.

    Science.gov (United States)

    Blondeau, S; Do, Q T; Scior, T; Bernard, P; Morin-Allory, L

    2010-05-01

    A huge amount of data has been generated by decades of pharmacognosy supported by the rapid evolution of chemical, biological and computational techniques. How can we cope with this overwhelming mass of information? Reverse pharmacognosy was introduced with this aim in view. It proceeds from natural molecules to organisms that contain them via biological assays in order to identify an activity. In silico techniques and particularly inverse screening are key technologies to achieve this goal efficiently. Reverse pharmacognosy allows us to identify which molecule(s) from an organism is(are) responsible for the biological activity and the biological pathway(s) involved. An exciting outcome of this approach is that it not only provides evidence of the therapeutic properties of plants used in traditional medicine for instance, but may also position other plants containing the same active compounds for the same usage, thus increasing the curative arsenal e.g. development of new botanicals. This is particularly interesting in countries where western medicines are still not affordable. At the molecular level, in organisms, families of metabolites are synthesized and seldom have a single structure. Hence, when a natural compound has an interesting activity, it may be desirable to check whether there are more active and/or less toxic derivatives in organisms containing the hit - this corresponds to a kind of "natural combinatorial" chemistry. At a time when the pharmaceutical industry is lacking drug candidates in clinical trials, drug repositioning - i.e. exploiting existing knowledge for innovation - has never been so critical. Reverse pharmacognosy can contribute to addressing certain issues in current drug discovery - such as the lack of clinical candidates, toxicity... - by exploiting existing data from pharmacognosy. This review will focus on recent advances in computer science applied to natural substance research that consolidate the new concept of reverse pharmacognosy.

  19. Harnessing the Gender Dividend to Boost Economic Growth in ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    In a context of hierarchical social relations unfavourable to women, and in the absence of supportive public policies, the process of women's increased participation to the labour market can lead to their over-representation in informal and / or low paying jobs. The analysis of female's labour force participation will therefore ...

  20. Harnessing Students' Interest in Physics with Their Own Video Games

    Science.gov (United States)

    Like, Christopher

    2011-04-01

    Many physics teachers assign projects where students are asked to measure real-world motion. One purpose of this student-centered activity is to cultivate the relevance of physics in their lives. Typical project topics may include measuring the speed of a student's fastball and calculating how much reaction time batters are given. Another student may find the trajectory of her dive off the blocks at the pool and its effect on race time. Leaving the experimental design to the student's imagination allows for a variety of proposals ranging from stopwatches to highly technical video analysis. The past few years have shown an increase in students' eagerness to tackle the physics behind the motion of virtual characters and phenomena in their own video games. This paper puts forth a method of analyzing the physics behind bringing the games students are playing for enjoyment into the physics classroom.

  1. Harnessing Nigeria's Biological Diversity in an Integrated Approach ...

    African Journals Online (AJOL)

    However, over the last three decades, there have being a progressive decrease in the country's biological diversity. Nigeria biological diversity has to be restored and conserved due to its relevance to human development in the areas of agriculture, human health, business and industry, leisure, cultural and aesthetic values ...

  2. Harnessing the power of enzymes for environmental stewardship.

    Science.gov (United States)

    Demarche, Philippe; Junghanns, Charles; Nair, Rakesh R; Agathos, Spiros N

    2012-01-01

    Enzymes are versatile catalysts with a growing number of applications in biotechnology. Their properties render them also attractive for waste/pollutant treatment processes and their use might be advantageous over conventional treatments. This review highlights enzymes that are suitable for waste treatment, with a focus on cell-free applications or processes with extracellular and immobilized enzymes. Biological wastes are treated with hydrolases, primarily to degrade biological polymers in a pre-treatment step. Oxidoreductases and lyases are used to biotransform specific pollutants of various nature. Examples from pulp and paper, textile, food and beverage as well as water and chemical industries illustrate the state of the art of enzymatic pollution treatment. Research directions in enzyme technology and their importance for future development in environmental biotechnology are elaborated. Beside biological and biochemical approaches, i.e. enzyme prospection and the design of enzymes, the review also covers efforts in adjacent research fields such as insolubilization of enzymes, reactor design and the use of additives. The effectiveness of enzymatic processes, especially when combined with established technologies, is evident. However, only a limited number of enzymatic field applications exist. Factors like cost and stability of biocatalysts need to be addressed and the collaboration and exchange between academia and industry should be further strengthened to achieve the goal of sustainability. Copyright © 2011 Elsevier Inc. All rights reserved.

  3. Action Plan for Harnessing Science and Technology towards ...

    Indian Academy of Sciences (India)

    LS SHASHIDHARA

    For India to achieve scientific 'self-sufficiency' and to assume scientific leadership in the world, there has to be a 'sustainable scientific support revolution' akin ..... nurtured as future leaders by providing ample opportunities to develop interpersonal skills and learning administrative skills in the management of resources etc.

  4. Harnessing sorghum and millet biotechnology for food and health

    CSIR Research Space (South Africa)

    O'Kennedy, MM

    2006-11-01

    Full Text Available lysine, but expression of the same gene in the starchy endosperm had no effect as increased breakdown of the lysine also occurred. Similar increased degradation has been reported in soybean and canola (oilseed rape) (Falco et al., 1995; Mazur et al... or increased growth when transgenic soybean and canola seeds were fed to pigs and chickens (Denbow et al., 1998; Zhang et al., 2000a, b). Fungal phytase has also been expressed in seeds of wheat and rice and current work on these crops is focussing...

  5. Action Plan for Harnessing Science and Technology towards ...

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1974 Section: Medicine. Salaskar, Dr Vishwanath Hari M.B.B.S., M.D.. Date of birth: 6 April 1912. Date of death: 8 September 1997. Specialization: Medical Enzymology Address: 69 A, 'Manisha', Lady Jagmohandas Marg, Neapeansea Road, Bombay 400 006. YouTube · Twitter · Facebook · Blog ...

  6. How an autonomous quantum Maxwell demon can harness correlated information.

    Science.gov (United States)

    Chapman, Adrian; Miyake, Akimasa

    2015-12-01

    We study an autonomous quantum system which exhibits refrigeration under an information-work trade-off like a Maxwell demon. The system becomes correlated as a single "demon" qubit interacts sequentially with memory qubits while in contact with two heat reservoirs of different temperatures. Using strong subadditivity of the von Neumann entropy, we derive a global Clausius inequality to show thermodynamic advantages from access to correlated information. It is demonstrated, in a matrix product density operator formalism, that our demon can simultaneously realize refrigeration against a thermal gradient and erasure of information from its memory, which is impossible without correlations. The phenomenon can be even enhanced by the presence of quantum coherence.

  7. TerraFERMA: Harnessing Advanced Computational Libraries in Earth Science

    Science.gov (United States)

    Wilson, C. R.; Spiegelman, M.; van Keken, P.

    2012-12-01

    Many important problems in Earth sciences can be described by non-linear coupled systems of partial differential equations. These "multi-physics" problems include thermo-chemical convection in Earth and planetary interiors, interactions of fluids and magmas with the Earth's mantle and crust and coupled flow of water and ice. These problems are of interest to a large community of researchers but are complicated to model and understand. Much of this complexity stems from the nature of multi-physics where small changes in the coupling between variables or constitutive relations can lead to radical changes in behavior, which in turn affect critical computational choices such as discretizations, solvers and preconditioners. To make progress in understanding such coupled systems requires a computational framework where multi-physics problems can be described at a high-level while maintaining the flexibility to easily modify the solution algorithm. Fortunately, recent advances in computational science provide a basis for implementing such a framework. Here we present the Transparent Finite Element Rapid Model Assembler (TerraFERMA), which leverages several advanced open-source libraries for core functionality. FEniCS (fenicsproject.org) provides a high level language for describing the weak forms of coupled systems of equations, and an automatic code generator that produces finite element assembly code. PETSc (www.mcs.anl.gov/petsc) provides a wide range of scalable linear and non-linear solvers that can be composed into effective multi-physics preconditioners. SPuD (amcg.ese.ic.ac.uk/Spud) is an application neutral options system that provides both human and machine-readable interfaces based on a single xml schema. Our software integrates these libraries and provides the user with a framework for exploring multi-physics problems. A single options file fully describes the problem, including all equations, coefficients and solver options. Custom compiled applications are generated from this file but share an infrastructure for services common to all models, e.g. diagnostics, checkpointing and global non-linear convergence monitoring. This maximizes code reusability, reliability and longevity ensuring that scientific results and the methods used to acquire them are transparent and reproducible. TerraFERMA has been tested against many published geodynamic benchmarks including 2D/3D thermal convection problems, the subduction zone benchmarks and benchmarks for magmatic solitary waves. It is currently being used in the investigation of reactive cracking phenomena with applications to carbon sequestration, but we will principally discuss its use in modeling the migration of fluids in subduction zones. Subduction zones require an understanding of the highly nonlinear interactions of fluids with solids and thus provide an excellent scientific driver for the development of multi-physics software.

  8. Harnessing Post-Conflict Transitions: A Conceptual Primer

    Science.gov (United States)

    2010-09-01

    of power theory and neo-realism (Waltz, 1979) are two closely related preconceptions in the field of international relations that rest on a...opposi- tion groups (1991, p. 114). While these theories are helpful in describing the phases, processes, and mode of transition to democ- racy, it is...fact that the great majority of transitional countries are somewhere in between authoritarianism and democracy, asserting that teleological , ideal

  9. Harnessing the power of the new SMP cluster architecture

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, S E; Cohen, R H; Curtis, B C; Dannevik, W P; Dimits, A M; Dinge, D; Eliason, D E; Hodsons, S; Jacobs, M; Mirin, A A; Porter, D H; Ruwart, T; Synne, I; Winkler, K; Woodward, P R

    1999-06-16

    In 1993, members of our team collaborated with Silicon Graphics to perform the first full-scale demonstration of the computational power of the SMP cluster supercomputer architecture. That demonstration involved the simulation of homogeneous, compressible turbulence on a uniform grid of a billion cells, using our PPM gas dynamics code. This computation was embarrassingly parallel, the ideal test case, and it achieved only 4.9 Gflop/s performance, slightly over half that achievable by this application on the most expensive supercomputers of that day. After four to five solid days of computation, when the prototype machine had to be dismantled, the simulation was only about 20% completed. Nevertheless, this computation gave us important new insights into compressible turbulence and also into a powerful new mode of cost-effective, commercially sustainable supercomputing [S]. In the intervening 6 years, the SMP cluster architecture has become a fundamental strategy for several large supercomputer centers in the US, including the DOE's ASCI centers at Los Alamos National Laboratory and at the Lawrence Livermore National Laboratory and the NSF's center NCSA at the University of Illinois. This SMP cluster architecture now underlies product offerings at the high-end of performance from SGI, IBM, and HP, among others. Nevertheless, despite many successes, it is our opinion that the computational science community is only now beginning to exploit the full promise of these new computing platforms. In this paper, we will briefly discuss two key architectural issues, vector computing and the flat multiprocessor architecture, which continue to drive spirited discussions among computational scientists, and then we will describe the hierarchical shared memory programming paradigm that we feel is best suited to the creative use of SMP cluster systems. Finally, we will give examples of recent large-scale simulations carried out by our team on these kinds of systems and point toward the still more challenging work which we foresee in the near future.

  10. Harnessing graphical structure in Markov chain Monte Carlo learning

    Energy Technology Data Exchange (ETDEWEB)

    Stolorz, P.E. [California Inst. of Technology, Pasadena, CA (United States); Chew P.C. [Univ. of Pennsylvania, Philadelphia, PA (United States)

    1996-12-31

    The Monte Carlo method is recognized as a useful tool in learning and probabilistic inference methods common to many datamining problems. Generalized Hidden Markov Models and Bayes nets are especially popular applications. However, the presence of multiple modes in many relevant integrands and summands often renders the method slow and cumbersome. Recent mean field alternatives designed to speed things up have been inspired by experience gleaned from physics. The current work adopts an approach very similar to this in spirit, but focusses instead upon dynamic programming notions as a basis for producing systematic Monte Carlo improvements. The idea is to approximate a given model by a dynamic programming-style decomposition, which then forms a scaffold upon which to build successively more accurate Monte Carlo approximations. Dynamic programming ideas alone fail to account for non-local structure, while standard Monte Carlo methods essentially ignore all structure. However, suitably-crafted hybrids can successfully exploit the strengths of each method, resulting in algorithms that combine speed with accuracy. The approach relies on the presence of significant {open_quotes}local{close_quotes} information in the problem at hand. This turns out to be a plausible assumption for many important applications. Example calculations are presented, and the overall strengths and weaknesses of the approach are discussed.

  11. Action Plan for Harnessing Science and Technology towards ...

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1959 Section: Chemistry. Dharmatti, Shrinivasa Shridhar Ph.D. (Bombay). Date of birth: 8 May 1911. Date of death: 2 May 1965. Specialization: Magnetochemistry. YouTube · Twitter · Facebook · Blog. Academy News. IAS Logo. Associates – 2017. Posted on 30 August 2017.

  12. Thermionic Power Cell To Harness Heat Energies for Geothermal Applications

    Science.gov (United States)

    Manohara, Harish; Mojarradi, Mohammad; Greer, Harold F.

    2011-01-01

    A unit thermionic power cell (TPC) concept has been developed that converts natural heat found in high-temperature environments (460 to 700 C) into electrical power for in situ instruments and electronics. Thermionic emission of electrons occurs when an emitter filament is heated to gwhite hot h temperatures (>1,000 C) allowing electrons to overcome the potential barrier and emit into the vacuum. These electrons are then collected by an anode, and transported to the external circuit for energy storage.

  13. Harnessing biodiversity: the Malagasy Institute of Applied Research (IMRA)

    Science.gov (United States)

    2010-01-01

    Background Biopiracy – the use of a people’s long-established medical knowledge without acknowledgement or compensation – has been a disturbing historical reality and exacerbates the global rich-poor divide. Bioprospecting, however, describes the commercialization of indigenous medicines in a manner acceptable to the local populace. Challenges facing bioprospectors seeking to develop traditional medicines in a quality-controlled manner include a lack of skilled labor and high-tech infrastructure, adapting Northern R&D protocols to Southern settings, keeping products affordable for the local population, and managing the threat of biopiracy. The Malagasy Institute of Applied Research (IMRA) has employed bioprospecting to develop new health treatments for conditions such as diabetes and burns. Because of its integration of Western science and Malagasy cultural traditions, IMRA may provide a useful example for African and other organizations interested in bioprospecting. Discussion IMRA’s approach to drug development and commercialization was adapted from the outset to Malagasy culture and Southern economic landscapes. It achieved a balance between employing Northern R&D practices and following local cultural norms through four guiding principles. First, IMRA’s researchers understood and respected local practices, and sought to use rather than resist them. Second, IMRA engaged the local community early in the drug development process, and ensured that local people had a stake in its success. Third, IMRA actively collaborated with local and international partners to increase its credibility and research capacity. Fourth, IMRA obtained foreign research funds targeting the “diseases of civilization” to cross-fund the development of drugs for conditions that affect the Malagasy population. These principles are illustrated in the development of IMRA products like Madeglucyl, a treatment for diabetes management that was developed from a traditional remedy. Summary By combining local and international research interests, IMRA has been able to keep its treatments affordable for the Malagasy population. Our analysis of IMRA’s history, strategy, and challenges suggests that other developing world institutions seeking to use bioprospecting to address issues of local access to medicines would be well-advised to treat traditional medical knowledge with respect and humility, share its benefits with the local community, and pursue strategic partnerships. PMID:21144080

  14. Fejlagtig kritik har afsporet miljødebatten

    DEFF Research Database (Denmark)

    Nørgaard, Jørgen

    2008-01-01

    a sustainable and decent life. The critique of L.t.G turns out to be based on claims with no substance in the report. On the contrary, so far nothing has indicated that the report was in any sense fundamentally wrong. Unfortunately the erroneous critique has managed to convince many that the report was wrong...

  15. Chelation: Harnessing and Enhancing Heavy Metal Detoxification—A Review

    Directory of Open Access Journals (Sweden)

    Margaret E. Sears

    2013-01-01

    Full Text Available Toxic metals such as arsenic, cadmium, lead, and mercury are ubiquitous, have no beneficial role in human homeostasis, and contribute to noncommunicable chronic diseases. While novel drug targets for chronic disease are eagerly sought, potentially helpful agents that aid in detoxification of toxic elements, chelators, have largely been restricted to overt acute poisoning. Chelation, that is multiple coordination bonds between organic molecules and metals, is very common in the body and at the heart of enzymes with a metal cofactor such as copper or zinc. Peptides glutathione and metallothionein chelate both essential and toxic elements as they are sequestered, transported, and excreted. Enhancing natural chelation detoxification pathways, as well as use of pharmaceutical chelators against heavy metals are reviewed. Historical adverse outcomes with chelators, lessons learned in the art of using them, and successes using chelation to ameliorate renal, cardiovascular, and neurological conditions highlight the need for renewed attention to simple, safe, inexpensive interventions that offer potential to stem the tide of debilitating, expensive chronic disease.

  16. Seat belts and shoulder harnesses : smart protection in small airplanes.

    Science.gov (United States)

    2004-05-01

    Seat belts alone will protect you only in minor impacts. : Using shoulder belts in small aircraft would reduce major injuries by 88% and fatalities by 20%. Shoulder belt kits are now available for most airplanes. : Proper use and installation of chil...

  17. Simulation Studies on Harnessing of Artificial Ecosystems in Space Colonies

    Science.gov (United States)

    Miyajima, Hiroyuki

    Space Colonies are an artificial habitation built in space, an idea first proposed by Gerard K. O'Neill in 1969. He suggested they be placed at Lagrange points which are points in space that balance out the gravitational attraction of the Earth and Moon. There are three types of space colonies proposed: Bernard, Cylinder, and Stanford Torus. The cylinder type, designed by Gerard K. O'Neill, is the most popular in concept at 6 km diameter and 30 km length, corresponding to about 845 cubic km, ten thousand people would potentially be able to reside these. The habitation area would be rotated to generate a quasi-gravitation by centrifugal force. It would be rotated at 0.55 rpm to generate a gravitation equivalent to that of the earth. In the space colony, there would be six areas axially, consisting of flooring and windows alternately. Mobile mirrors would be located outside the windows to reflect sun light toward the habitation areas and generate day, night, and seasons within the space colony. Thus an artificial ecosystem would be created allowing people live in much the same way as they do on the earth. According to my former research on micro ecosystems, it is very difficult to keep the environment balanced at all points due to the large volume of the habitation area and the thermal input of the mobile mirrors. It is predicted that there will be differences in the environment at each point of the cylinder due to the mirror angle. Although controlling the whole artificial ecosystem balance is important, local environment control at each point is also important for people to live and work comfortably. Therefore, it is needed to develop simulation models which can study the whole ecosystem as well as local environments at each point at the same time. This model has to be able to simulate dynamics of the whole system as well as the local environments. In this study, I have developed a new model to simulate the whole and local dynamics in a space colony by using a cell automaton consisting of structure, thermal, air, water, and vegetation models.

  18. Annotating images by harnessing worldwide user-tagged photos

    NARCIS (Netherlands)

    Li, X.; Snoek, C.G.M.; Worring, M.

    2009-01-01

    Automatic image tagging is important yet challenging due to the semantic gap and the lack of learning examples to model a tag's visual diversity. Meanwhile, social user tagging is creating rich multimedia content on the Web. In this paper, we propose to combine the two tagging approaches in a

  19. Action Plan for Harnessing Science and Technology towards ...

    Indian Academy of Sciences (India)

    . (Univ. Calif., Berkeley), FNA. Date of birth: 1 January 1935. Date of death: 15 November 2004. Specialization: Genetics, Cell Biology and Cytogenetics Last known address: Professor, Genetic Research Unit, Department of Zoology, University ...

  20. Action Plan for Harnessing Science and Technology towards ...

    Indian Academy of Sciences (India)

    Wisconsin), FNA, FNAAS. Date of birth: 10 October 1921. Date of death: 6 December 2004. Specialization: Genetics, Cytogenetics and Forest Tree Breeding Last known address: 12-A, 1st Cross Road, V Layout, Ramalinga Nagar, K K Pudur Post, ...

  1. Adverse Event Reporting: Harnessing Residents to Improve Patient Safety.

    Science.gov (United States)

    Tevis, Sarah E; Schmocker, Ryan K; Wetterneck, Tosha B

    2017-10-13

    Reporting of adverse and near miss events are essential to identify system level targets to improve patient safety. Resident physicians historically report few events despite their role as front-line patient care providers. We sought to evaluate barriers to adverse event reporting in an effort to improve reporting. Our main outcomes were as follows: resident attitudes about event reporting and the frequency of event reporting before and after interventions to address reporting barriers. We surveyed first year residents regarding barriers to adverse event reporting and used this input to construct a fishbone diagram listing barriers to reporting. Barriers were addressed, and resident event reporting was compared before and after efforts were made to reduce obstacles to reporting. First year residents (97%) recognized the importance of submitting event reports; however, the majority (85%) had not submitted an event report in the first 6 months of residency. Only 7% of residents specified that they had not witnessed an adverse event in 6 months, whereas one third had witnessed 10 or more events. The main barriers were as follows: lack of knowledge about how to submit events (38%) and lack of time to submit reports (35%). After improving resident education around event reporting and simplifying the reporting process, resident event reporting increased 230% (68 to 154 annual reports, P = 0.025). We were able to significantly increase resident event reporting by educating residents about adverse events and near misses and addressing the primary barriers to event reporting. Moving forward, we will continue annual resident education about patient safety, focus on improving feedback to residents who submit reports, and empower senior residents to act as role models to junior residents in patient safety initiatives.

  2. Of Radicals and DREAMers: Harnessing Exceptionality to Challenge Immigration Control

    Science.gov (United States)

    Heredia, Luisa Laura

    2015-01-01

    This article contributes to the literature on undocumented youth activism and citizenship by assessing undocumented youth's challenges to a growing regime of migration control in the US. It uses Doug McAdam's tactical interaction as an analytical lens to explore two consecutive high-risk campaigns, ICE infiltrations and expulsion/re-entry. In this…

  3. Harnessing Open Data to Achieve Development Results in Latin ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This project aims to strengthen the accountability and legitimacy of public institutions, improve public services, and fuel economic growth in Latin America and the Caribbean through research and innovation on open data initiatives. The value of open data Open data refers to releasing freely accessible, standardized, and ...

  4. Harnessing Hydropower: The Earth's Natural Resource

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-04-01

    This document is a layman's overview of hydroelectric power. It includes information on: History of Hydropower; Nature’s Water Cycle; Hydropower Plants; Turbines and Generators; Transmission Systems; power dispatching centers; and Substations. It goes on to discuss The Power Grid, Hydropower in the 21st Century; Energy and the Environment; and how hydropower is useful for Meeting Peak Demands. It briefly addresses how Western Area Power Administration is Responding to Environmental Concerns.

  5. Semantic acquisition games harnessing manpower for creating semantics

    CERN Document Server

    Šimko, Jakub

    2014-01-01

    A comprehensive and extensive review of state-of-the-art in semantics acquisition game (SAG) design A set of design patterns for SAG designers A set of case studies (real SAG projects) demonstrating the use of SAG design patterns

  6. Patienter med KOL har lav mediciadhærens

    DEFF Research Database (Denmark)

    Lange, Peter; Toettenborg, Sandra; Topp, Marie

    2014-01-01

    Medicine adherence in patients with obstructive pulmonary disease (COPD), has not been studied in Denmark. Studies from other countries, however, unequivocally report low prevalence of patients who follow their doctor's advice and have sufficient adherence to inhaled medicine. In this review we...... describe results of previous studies on prevalence of adherence to inhaled medicine in COPD, and define characteristics of the patients and treatment associated with degree of adherence. We conclude that health professionals should always consider non-adherence, strive to simplify regiments......, and that there is an urgent need of studies aiming at improving adherence in patients with COPD....

  7. Research priorities for harnessing plant microbiomes in sustainable agriculture.

    Science.gov (United States)

    Busby, Posy E; Soman, Chinmay; Wagner, Maggie R; Friesen, Maren L; Kremer, James; Bennett, Alison; Morsy, Mustafa; Eisen, Jonathan A; Leach, Jan E; Dangl, Jeffery L

    2017-03-01

    Feeding a growing world population amidst climate change requires optimizing the reliability, resource use, and environmental impacts of food production. One way to assist in achieving these goals is to integrate beneficial plant microbiomes-i.e., those enhancing plant growth, nutrient use efficiency, abiotic stress tolerance, and disease resistance-into agricultural production. This integration will require a large-scale effort among academic researchers, industry researchers, and farmers to understand and manage plant-microbiome interactions in the context of modern agricultural systems. Here, we identify priorities for research in this area: (1) develop model host-microbiome systems for crop plants and non-crop plants with associated microbial culture collections and reference genomes, (2) define core microbiomes and metagenomes in these model systems, (3) elucidate the rules of synthetic, functionally programmable microbiome assembly, (4) determine functional mechanisms of plant-microbiome interactions, and (5) characterize and refine plant genotype-by-environment-by-microbiome-by-management interactions. Meeting these goals should accelerate our ability to design and implement effective agricultural microbiome manipulations and management strategies, which, in turn, will pay dividends for both the consumers and producers of the world food supply.

  8. Action Plan for Harnessing Science and Technology towards ...

    Indian Academy of Sciences (India)

    Date of birth: 27 November 1898. Date of death: 26 July 1984. Specialization: Higher Dynamics, Ferromagnetics and Hydrodynamics. YouTube · Twitter · Facebook · Blog. Academy News. IAS Logo. Live streaming of the Symposium on Dialogue: Science, Scientists, and Society starts at 2:00 pm IST on the 13th of October – ...

  9. Big Mac arvestab raha ostujõudu / Harli Uljas

    Index Scriptorium Estoniae

    Uljas, Harli

    2005-01-01

    The Economist võrdleb maailma valuutade suhestamiseks Big Mac'i burgeri hindu 120 riigis, kuna see meetod võimaldab saada ülevaate riikide elanikkonna tegelikust ostujõust. Tabel: Hamburgeri standard

  10. Harnessing Adaptive Optics for Space Debris Collision Mitigation

    Science.gov (United States)

    Zovaro, A.; Bennet, F.; Copeland, M.; Rigaut, F.; d'Orgeville, C.; Grosse, D.

    2016-09-01

    Human kind's continued use of space depends upon minimising the build-up of debris in low Earth-orbit (LEO). Preventing collisions between satellites and debris is essential given that a single collision can generate thousands of new debris objects. However, in-orbit manoeuvring of satellites is extremely expensive and shortens their operational life. Adjusting the orbits of debris objects instead of satellites would shift the responsibility of collision avoidance away from satellite operators altogether, thereby offering a superior solution. The Research School of Astronomy and Astrophysics at the Australian National University, partnered with Electro Optic Systems (EOS) Space Systems, Lockheed Martin Corporation and the Space Environment Research Centre (SERC) Limited, are developing the Adaptive Optics Tracking and Pushing (AOTP) system. AOTP will be used to perturb the orbits of debris objects using photon pressure from a 10 kW IR laser beam launched from the 1.8 m telescope at Mount. Stromlo Observatory, Australia. Initial simulations predict that AOTP will be able to displace debris objects 10 cm in size by up to 100 m with several overhead passes. An operational demonstrator is planned for 2019. Turbulence will distort the laser beam as it propagates through the atmosphere, resulting in a lower photon flux on the target and reduced pointing accuracy. To mitigate these effects, adaptive optics (AO) will be used to apply wavefront correction to the beam prior to launch. A unique challenge in designing the AO system arises from the high slew rate needed to track objects in LEO, which in turn requires laser guide star AO for satisfactory wavefront correction. The optical design and results from simulations of estimated performance of AOTP will be presented. In particular, design considerations associated with the high-power laser will be detailed.

  11. Harnessing Satellite Imageries in Feature Extraction Using Google Earth Pro

    Science.gov (United States)

    Fernandez, Sim Joseph; Milano, Alan

    2016-07-01

    Climate change has been a long-time concern worldwide. Impending flooding, for one, is among its unwanted consequences. The Phil-LiDAR 1 project of the Department of Science and Technology (DOST), Republic of the Philippines, has developed an early warning system in regards to flood hazards. The project utilizes the use of remote sensing technologies in determining the lives in probable dire danger by mapping and attributing building features using LiDAR dataset and satellite imageries. A free mapping software named Google Earth Pro (GEP) is used to load these satellite imageries as base maps. Geotagging of building features has been done so far with the use of handheld Global Positioning System (GPS). Alternatively, mapping and attribution of building features using GEP saves a substantial amount of resources such as manpower, time and budget. Accuracy-wise, geotagging by GEP is dependent on either the satellite imageries or orthophotograph images of half-meter resolution obtained during LiDAR acquisition and not on the GPS of three-meter accuracy. The attributed building features are overlain to the flood hazard map of Phil-LiDAR 1 in order to determine the exposed population. The building features as obtained from satellite imageries may not only be used in flood exposure assessment but may also be used in assessing other hazards and a number of other uses. Several other features may also be extracted from the satellite imageries.

  12. Harnessing Orbital Debris to Sense the Space Environment

    Science.gov (United States)

    Mutschler, S.; Axelrad, P.; Matsuo, T.

    A key requirement for accurate space situational awareness (SSA) is knowledge of the non-conservative forces that act on space objects. These effects vary temporally and spatially, driven by the dynamical behavior of space weather. Existing SSA algorithms adjust space weather models based on observations of calibration satellites. However, lack of sufficient data and mismodeling of non-conservative forces cause inaccuracies in space object motion prediction. The uncontrolled nature of debris makes it particularly sensitive to the variations in space weather. Our research takes advantage of this behavior by inverting observations of debris objects to infer the space environment parameters causing their motion. In addition, this research will produce more accurate predictions of the motion of debris objects. The hypothesis of this research is that it is possible to utilize a "cluster" of debris objects, objects within relatively close proximity of each other, to sense their local environment. We focus on deriving parameters of an atmospheric density model to more precisely predict the drag force on LEO objects. An Ensemble Kalman Filter (EnKF) is used for assimilation; the prior ensemble to the posterior ensemble is transformed during the measurement update in a manner that does not require inversion of large matrices. A prior ensemble is utilized to empirically determine the nonlinear relationship between measurements and density parameters. The filter estimates an extended state that includes position and velocity of the debris object, and atmospheric density parameters. The density is parameterized as a grid of values, distributed by latitude and local sidereal time over a spherical shell encompassing Earth. This research focuses on LEO object motion, but it can also be extended to additional orbital regimes for observation and refinement of magnetic field and solar radiation models. An observability analysis of the proposed approach is presented in terms of the measurement cadence necessary to estimate the local space environment.

  13. Network harness: bundles of routes in public transport networks

    OpenAIRE

    Berche, B.; von Ferber, C.; Holovatch, T.

    2009-01-01

    Public transport routes sharing the same grid of streets and tracks are often found to proceed in parallel along shorter or longer sequences of stations. Similar phenomena are observed in other networks built with space consuming links such as cables, vessels, pipes, neurons, etc. In the case of public transport networks (PTNs) this behavior may be easily worked out on the basis of sequences of stations serviced by each route. To quantify this behavior we use the recently introduced notion of...

  14. Har samfundstjeneste en præventiv effekt?

    DEFF Research Database (Denmark)

    Clausen, Susanne

    2007-01-01

    Do Offenders Sentenced to Community Service Have Lower Rates of Recidivism than Offenders Sentenced to Imprisonment? The Community Service Programme (CS) was introduced in Denmark in 1982. The programme offers an alternative to incarceration in which offenders are sentenced to anywhere from 30...... to 240 hours of unpaid work benefiting the community. The article presents results from an effect evaluation which is part of a dissertation about the Danish CS. The effect evaluation examines whether offenders sentenced to CS have lower rates of recidivism than offenders sentenced to imprisonment...... in judicial policy in the late 1990s after which the courts more frequently sentenced violent offenders to CS. The evaluation shows that after controlling for criminal history and socio-economic circumstances, some offenders sentenced to CS have lower rates of recidivism than offenders sentenced to prison...

  15. Toward a superconducting quantum computer. Harnessing macroscopic quantum coherence.

    Science.gov (United States)

    Tsai, Jaw-Shen

    2010-01-01

    Intensive research on the construction of superconducting quantum computers has produced numerous important achievements. The quantum bit (qubit), based on the Josephson junction, is at the heart of this research. This macroscopic system has the ability to control quantum coherence. This article reviews the current state of quantum computing as well as its history, and discusses its future. Although progress has been rapid, the field remains beset with unsolved issues, and there are still many new research opportunities open to physicists and engineers.

  16. Harnessing Disordered-Ensemble Quantum Dynamics for Machine Learning

    Science.gov (United States)

    Fujii, Keisuke; Nakajima, Kohei

    2017-08-01

    The quantum computer has an amazing potential of fast information processing. However, the realization of a digital quantum computer is still a challenging problem requiring highly accurate controls and key application strategies. Here we propose a platform, quantum reservoir computing, to solve these issues successfully by exploiting the natural quantum dynamics of ensemble systems, which are ubiquitous in laboratories nowadays, for machine learning. This framework enables ensemble quantum systems to universally emulate nonlinear dynamical systems including classical chaos. A number of numerical experiments show that quantum systems consisting of 5-7 qubits possess computational capabilities comparable to conventional recurrent neural networks of 100-500 nodes. This discovery opens up a paradigm for information processing with artificial intelligence powered by quantum physics.

  17. Harnessing Students' Interest in Physics with Their Own Video Games

    Science.gov (United States)

    Like, Christopher

    2011-01-01

    Many physics teachers assign projects where students are asked to measure real-world motion. One purpose of this student-centered activity is to cultivate the relevance of physics in their lives. Typical project topics may include measuring the speed of a student's fastball and calculating how much reaction time batters are given. Another student…

  18. Harnessing Open Data to Achieve Development Results in Latin ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Previous open data studies have also highlighted the lack of focus on the unintended consequences of implementing open data initiatives, such as personal privacy ... Working in coordination with governments, the private sector, and civil society, these initiatives will explore measures to influence demand for, and use of, ...

  19. OPEC suurendas sõja hirmus tootmiskvoote / Harli Uljas

    Index Scriptorium Estoniae

    Uljas, Harli

    2003-01-01

    Venezuela naftatootmise peatamisest tingitud nõudluse katmiseks suurendas OPEC 1,5 miljoni barreli võrra päevas tootmiskvoote. Autokütuste hindade ja Iraagi sõja ohu seosest. Tabel: OPEC: naftakvoodid

  20. Action Plan for Harnessing Science and Technology towards ...

    Indian Academy of Sciences (India)

    ... Public Lectures · Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Fellowship. Fellow Profile. Elected: 1968 Section: Medicine. Jhala, Harshadray Ishverlal M.D. (London). Date of birth: 13 January 1919. Date of death: 29 August 1984. Specialization: Microbiology, Immunology, Bacteriology.

  1. Harnessing marketing automation for B2B content marketing

    OpenAIRE

    Järvinen, Joel; Taiminen, Heini

    2016-01-01

    The growing importance of the Internet to B2B customer purchasing decisions has motivated B2B sellers to create digital content that leads potential buyers to interact with their company. This trend has engendered a new paradigm referred to as ‘content marketing.’ This study investigates the organizational processes for developing valuable and timely content to meet customer needs and for integrating content marketing with B2B selling processes. The results of this single case study demonstra...

  2. Non-communicable diseases – harnessing the current opportunities

    DEFF Research Database (Denmark)

    Sørensen, Jane Brandt; Demaio, Alessandro Rhyll; Østergaard, Lise Rosendal

    2012-01-01

    Non-communicable diseases (NCDs) receive growing attention, which brings a unique opportunity to utilise solutions available to address them. These diseases are largely preventable; proven, cost-effective interventions are available; and when NCDs have emerged, means exist to treat them, prevent...... complications, and to improve quality of life. Yet, there is a lack in progress in responding effectively to NCDs, and the current discussion and research focus predominantly on challenges rather than the opportunities, which this paper outlines....

  3. Harnessing innovation in passenger transport research in Africa

    CSIR Research Space (South Africa)

    Mokonyama, Mathetha T

    2006-07-01

    Full Text Available The paper provides the framework proposed by the newly established Built Environment Unit of CSIR, a public institution, to provide foresight driven research input into the passenger transport domain. This is modelled on the mandate of the CSIR...

  4. Harnessing Aptamers to Overcome Challenges in Gluten Detection

    Science.gov (United States)

    Miranda-Castro, Rebeca; de-los-Santos-Álvarez, Noemí; Miranda-Ordieres, Arturo J.; Lobo-Castañón, María Jesús

    2016-01-01

    Celiac disease is a lifelong autoimmune disorder triggered by foods containing gluten, the storage protein in wheat, rye, and barley. The rapidly escalating number of patients diagnosed with this disease poses a great challenge to both food industry and authorities to guarantee food safety for all. Therefore, intensive efforts are being made to establish minimal disease-eliciting doses of gluten and consequently to improve gluten-free labeling. These efforts depend to a high degree on the availability of methods capable of detecting the protein in food samples at levels as low as possible. Current analytical approaches rely on the use of antibodies as selective recognition elements. With limited sensitivity, these methods exhibit some deficiencies that compromise the accuracy of the obtained results. Aptamers provide an ideal alternative for designing biosensors for fast and selective measurement of gluten in foods. This article highlights the challenges in gluten detection, the current status of the use of aptamers for solving this problem, and what remains to be done to move these systems into commercial applications. PMID:27104578

  5. Harnessing genomics to identify environmental determinants of heritable disease

    Science.gov (United States)

    De novo mutation is increasingly being recognized as the cause for a range of human genetic diseases and disorders. Important examples of this include inherited genetic disorders such as autism, schizophrenia, mental retardation, epilepsy, and a broad range of adverse reproductiv...

  6. Mere end hver tiende har symptomer på vinterdepression

    DEFF Research Database (Denmark)

    Madsen, Helle Østergaard; Dam, Ole Henrik; Hageman, Ida

    2011-01-01

    Seasonal affective disorder is a syndrome of classical depressive symptoms such as reduced energy, initiative and mood combined with atypical symptoms of increased appetite, weight and sleep duration. The symptoms recur each winter and disappear again in spring or early summer. The prevalence...... ranges from 1% to 10% in Scandinavian populations. Reduced light exposure, melatonergic and serotonergic disturbances are suggested pathogenetic factors. Light therapy offers convincing effect with minimal adverse effects and remains first-line treatment along with selective serotonin reuptake inhibitors....

  7. Alfred Chandler viis äriajaloo massidesse / Harli Uljas

    Index Scriptorium Estoniae

    Uljas, Harli

    2007-01-01

    Majandusteadlane Alfred Chandler oli esimene, kes tõi kasutusse väite, et muutused strateegias saavad olla edukad vaid juhul, kui juhid suunavad ka ettevõtte toimima uutmoodi. Teda peetakse suurkorporatsiooni äriajaloo leiutajaks. Artikkel sisaldab loetelu A. Chandleri kirjutistest

  8. Action Plan for Harnessing Science and Technology towards ...

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1939 Section: Earth & Planetary Sciences. Venkiteshwaran, Sekharipuram Padmanabhaiyer B.A. (Hons.), FNA 1965-67. Date of birth: 15 February 1905. Date of death: 26 September 1985. Specialization: Instrumentation, Radio Meteorology and Wind Power. YouTube; Twitter; Facebook; Blog ...

  9. Endel Siff alustab infotehnoloogiaäriga / Harli Uljas

    Index Scriptorium Estoniae

    Uljas, Harli

    2000-01-01

    Maailma suurim infohaldustarkvara firma Oracle ja naftaärimees Endel Siffi äriinfo haldusfirma NT-Exchange.com sõlmisid tarkvara ostulepingu, mille abil hakatakse Eesti ettevõtetele pakkuma infohaldusteenuseid

  10. Harnessing the sharing economy in developing countries | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Digital marketplace platforms like AirBnB and Uber, sometimes referred to as the sharing economy, have become an essential part of the digital economy in recent years. The sharing economy is powered by applications and platforms that allow private individuals to share assets or services between them, either free or for a ...

  11. Harnessing Prefrontal Cognitive Signals for Brain-Machine Interfaces.

    Science.gov (United States)

    Min, Byoung-Kyong; Chavarriaga, Ricardo; Millán, José Del R

    2017-07-01

    Brain-machine interfaces (BMIs) enable humans to interact with devices by modulating their brain signals. Despite impressive technological advancements, several obstacles remain. The most commonly used BMI control signals are derived from the brain areas involved in primary sensory- or motor-related processing. However, these signals only reflect a limited range of human intentions. Therefore, additional sources of brain activity for controlling BMIs need to be explored. In particular, higher-order cognitive brain signals, specifically those encoding goal-directed intentions, are natural candidates for enlarging the repertoire of BMI control signals and making them more efficient and intuitive. Thus, here, we identify the prefrontal brain area as a key target region for future BMIs, given its involvement in higher-order, goal-oriented cognitive processes. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Harnessing Apoptotic Cell Clearance to Treat Autoimmune Arthritis

    OpenAIRE

    Philippe Saas; Francis Bonnefoy; Eric Toussirot; Sylvain Perruche

    2017-01-01

    Early-stage apoptotic cells possess immunomodulatory properties. Proper apoptotic cell clearance during homeostasis has been shown to limit subsequent immune responses. Based on these observations, early-stage apoptotic cell infusion has been used to prevent unwanted inflammatory responses in different experimental models of autoimmune diseases or transplantation. Moreover, this approach has been shown to be feasible without any toxicity in patients undergoing allogeneic hematopoietic cell tr...

  13. Harnessing demographic change for economic growth in Africa ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    17 avr. 2015 ... Public health and education consumption profiles show that the government is already pursuing policies to increase the prospects of future higher demographic dividends by investing in improving child mortality rates, reproductive health, discouraging child marriage and delaying first pregnancy, and ...

  14. Harnessing Technology to Assess Oral Communication in Business English

    Science.gov (United States)

    Levy, Tal; Gertler, Hedy

    2015-01-01

    Assessing oral skills in relatively large Business English classes seems a most formidable task for any teacher. How does one make sure to get multiple and valid assessments of each student? This action research paper provides supporting evidence for the correlation between the use of technology and students' engagement. This was achieved by…

  15. Harnessing the power of advertising to prevent childhood obesity

    Science.gov (United States)

    2013-01-01

    Background Social marketing integrates communication campaigns with behavioural and environmental change strategies. Childhood obesity programs could benefit significantly from social marketing but communication campaigns on this issue tend to be stand-alone. Methods A large-scale multi-setting child obesity prevention program was implemented in the Hunter New England (HNE) region of New South Wales (NSW), Australia from 2005–2010. The program included a series of communication campaigns promoting the program and its key messages: drinking water; getting physically active and; eating more vegetables and fruit. Pre-post telephone surveys (n = 9) were undertaken to evaluate awareness of the campaigns among parents of children aged 2–15 years using repeat cross-sections of randomly selected cohorts. A total of 1,367 parents (HNE = 748, NSW = 619) participated. Results At each survey post baseline, HNE parents were significantly more likely to have seen, read or heard about the program and its messages in the media than parents in the remainder of the state (p communication campaigns increased and maintained awareness of childhood obesity prevention messages. Moreover, messages were delivered equitably to diverse socio-demographic groups within the region. PMID:24090174

  16. Harnessing the power of enterprise to reduce poverty and conflict ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2011-01-26

    , such as honey production. Fostering grassroots knowledge. Another positive spin-off from the Forum was a work-internship program, which has grown to include students from four universities across Sudan and spanning ...

  17. Harnessing the Wandering Mind: The Role of Perceptual Load

    Science.gov (United States)

    Forster, Sophie; Lavie, Nilli

    2009-01-01

    Perceptual load is a key determinant of distraction by task-irrelevant stimuli (e.g., Lavie, N. (2005). "Distracted and confused?: Selective attention under load." "Trends in Cognitive Sciences," 9, 75-82). Here we establish the role of perceptual load in determining an internal form of distraction by task-unrelated thoughts (TUTs or…

  18. Harnessing CRISPR-Cas9 immunity for genetic engineering.

    Science.gov (United States)

    Charpentier, Emmanuelle; Marraffini, Luciano A

    2014-06-01

    CRISPR-Cas encodes an adaptive immune system that defends prokaryotes against infectious viruses and plasmids. Immunity is mediated by Cas nucleases, which use small RNA guides (the crRNAs) to specify a cleavage site within the genome of invading nucleic acids. In type II CRISPR-Cas systems, the DNA-cleaving activity is performed by a single enzyme Cas9 guided by an RNA duplex. Using synthetic single RNA guides, Cas9 can be reprogrammed to create specific double-stranded DNA breaks in the genomes of a variety of organisms, ranging from human cells to bacteria, and thus constitutes a powerful tool for genetic engineering. Here we describe recent advancements in our understanding of type II CRISPR-Cas immunity and how these studies led to revolutionary genome editing applications. Copyright © 2014. Published by Elsevier Ltd.

  19. Harnessing Social Media Collaborative Intelligence to Champion Enterprise Innovation

    Science.gov (United States)

    Juntiwasarakij, Suwan

    2012-01-01

    Innovation is a survival tool for the corporate world to play in the ever competitive free global market in the 21st century. The innovation process, especially at the front end, is the most challenging phase because of the inextricably intertwined fuzziness of high uncertainty and the deficiency of information available. Although the uncertainty…

  20. Ved du hvem der har dine sundhedsdata? Og hvorfor?

    DEFF Research Database (Denmark)

    Ploug, Thomas; Birkler, Jacob; Greisen, Gorm

    2015-01-01

    Sundhedsvæsenets flid med at indsamle data om vores sundhed gør Danmark til et eldorado for sundhedsforskning. Det kan både gøre borgerne sundere og landet rigere. Men der er også en bagside, når der er nem adgang til helt private og følsomme oplysninger.......Sundhedsvæsenets flid med at indsamle data om vores sundhed gør Danmark til et eldorado for sundhedsforskning. Det kan både gøre borgerne sundere og landet rigere. Men der er også en bagside, når der er nem adgang til helt private og følsomme oplysninger....

  1. Harnessing the power of advertising to prevent childhood obesity.

    Science.gov (United States)

    Bell, Andrew Colin; Wolfenden, Luke; Sutherland, Rachel; Coggan, Lucy; Young, Kylie; Fitzgerald, Michael; Hodder, Rebecca; Orr, Neil; Milat, Andrew J; Wiggers, John

    2013-10-04

    Social marketing integrates communication campaigns with behavioural and environmental change strategies. Childhood obesity programs could benefit significantly from social marketing but communication campaigns on this issue tend to be stand-alone. A large-scale multi-setting child obesity prevention program was implemented in the Hunter New England (HNE) region of New South Wales (NSW), Australia from 2005-2010. The program included a series of communication campaigns promoting the program and its key messages: drinking water; getting physically active and; eating more vegetables and fruit. Pre-post telephone surveys (n = 9) were undertaken to evaluate awareness of the campaigns among parents of children aged 2-15 years using repeat cross-sections of randomly selected cohorts. A total of 1,367 parents (HNE = 748, NSW = 619) participated. At each survey post baseline, HNE parents were significantly more likely to have seen, read or heard about the program and its messages in the media than parents in the remainder of the state (p < 0.001). Further, there was a significant increase in awareness of the program and each of its messages over time in HNE compared to no change over time in NSW (p < 0.001). Awareness was significantly higher (p < 0.05) in HNE compared to NSW after each specific campaign (except the vegetable one) and significantly higher awareness levels were sustained for each campaign until the end of the program. At the end of the program participants without a tertiary education were significantly more likely (p = 0.04) to be aware of the brand campaign (31%) than those with (20%) but there were no other statistically significant socio-demographic differences in awareness. The Good for Kids communication campaigns increased and maintained awareness of childhood obesity prevention messages. Moreover, messages were delivered equitably to diverse socio-demographic groups within the region.

  2. The American farm: Harnessing the sun to fuel the world

    Energy Technology Data Exchange (ETDEWEB)

    1994-03-01

    This NREL publication forecasts the future in energy crops. Tomorrow`s farm will produce crops like corn, soybeans, rapeseed, sunflowers for food and fuel. Farmers will harvest switchgrass and then sell it for feed or to make ethanol. Aspects of planting trees that are beneficial to the environment such as filtering run-off water are discussed. Economic issues of energy crop growth are presented. The harvesting of trees for pulp, paper, and energy and corn for electricity, fuels, and chemicals are both emphasized. Tree harvesting research from breeding programs to high-tech harvesting techniques is presented.

  3. Harnessing the Interaction Continuum for Subtle Assisted Living

    Science.gov (United States)

    García-Herranz, Manuel; Olivera, Fernando; Haya, Pablo; Alamán, Xavier

    2012-01-01

    People interact with each other in many levels of attention, intention and meaning. This Interaction Continuum is used daily to deal with different contexts, adapting the interaction to communication needs and available resources. Nevertheless, computer-supported interaction has mainly focused on the most direct, explicit and intrusive types of human to human Interaction such as phone calls, emails, or video conferences. This paper presents the results of exploring and exploiting the potentials of undemanding interaction mechanisms, paying special attention to subtle communication and background interaction. As we argue the benefits of this type of interaction for people with special needs, we present a theoretical framework to define it and propose a proof of concept based on Augmented Objects and a color codification mechanism. Finally, we evaluate and analyze the strengths and limitations of such approach with people with cognitive disabilities. PMID:23012573

  4. Can calcium signaling be harnessed for cancer immunotherapy?

    Science.gov (United States)

    Rooke, Ronald

    2014-10-01

    Experimental evidence shows the importance of the immune system in controlling tumor appearance and growth. Immunotherapy is defined as the treatment of a disease by inducing, enhancing or suppressing an immune response. In the context of cancer treatment, it involves breaking tolerance to a cancer-specific self-antigen and/or enhancing the existing anti-tumor immune response, be it specific or not. Part of the complexity in developing such treatment is that cancers are selected to escape adaptive or innate immune responses. These escape mechanisms are numerous and they may cumulate in one cancer. Moreover, different cancers of a same type may present different combinations of escape mechanisms. The limited success of immunotherapeutics in the clinic as stand-alone products may in part be explained by the fact that most of them only activate one facet of the immune response. It is important to identify novel methods to broaden the efficacy of immunotherapeutics. Calcium signaling is central to numerous cellular processes, leading to immune responses, cancer growth and apoptosis induced by cancer treatments. Calcium signaling in cancer therapy and control will be integrated to current cancer immunotherapy approaches. This article is part of a Special Issue entitled: Calcium Signaling in Health and Disease. Guest Editors: Geert Bultynck, Jacques Haiech, Claus W. Heizmann, Joachim Krebs, and Marc Moreau. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. Harnessing mobile genetic elements to explore gene regulation.

    Science.gov (United States)

    Shakes, Leighcraft A; Wolf, Hope M; Norford, Derek C; Grant, Delores J; Chatterjee, Pradeep K

    2014-01-01

    Sequences that regulate expression of a gene in cis but are located at large distances along the DNA from the gene, as found with most developmentally regulated genes in higher vertebrates, are difficult to identify if those sequences are not conserved across species. Mutating suspected gene-regulatory sequences to alter expression then becomes a hit-or-miss affair. The relaxed specificity of transposon insertions offers an opportunity to develop alternate strategies, to scan in an unbiased manner, pieces of chromosomal DNA cloned in BACs for transcription enhancing elements. This article illustrates how insertions of Tn10 with enhancer-traps into BAC DNA containing the gene, and its germ-line expression in zebrafish, have identified distal regulatory elements functionally. Transposition of Tn10 first introduces the enhancer-trap with a loxP site randomly into BAC DNA. Cre-recombination between the inserted loxP and the loxP endogenous to a BAC-end positions the enhancer-trap to the newly created truncated end of BAC DNA. The procedure generates a library of integration-ready enhancer-trap BACs with progressive truncations from an end in a single experiment. Individual enhancer-trap BACs from the library can be evaluated functionally in zebrafish or mice. Furthermore, the ability to readily alter sequences in a small transposon plasmid containing a regulatory domain of the gene allows re-introduction of altered parts of a BAC back into itself. It serves as a useful strategy to functionally dissect multiple discontinuous regulatory domains of a gene quickly. These methodologies have been successfully used in identifying novel regulatory domains of the Amyloid Precursor Protein (appb) gene in zebrafish, and provided important clues for regulation of the gene in humans.

  6. Det har vi lært af Nakuusa

    DEFF Research Database (Denmark)

    Christensen, Else

    Undersøgelsen er den sidste i en række på fire delundersøgelser, der følger projektet NAKUUSA, der består af en række aktiviteter/projekter, der skal sikre, at børns vilkår og rettigheder styrkes i Grønland. Denne undersøgelse ser på de unge, der er med i NAKUUSAs børnepanel. Undersøgelsen belyse...... og gennemføres af Departementet for Familie, Ligestilling og Sociale Anliggender, Selvstyret i Grønland og UNICEF i Danmark....

  7. Technological innovations in mental healthcare: harnessing the digital revolution.

    Science.gov (United States)

    Hollis, Chris; Morriss, Richard; Martin, Jennifer; Amani, Sarah; Cotton, Rebecca; Denis, Mike; Lewis, Shôn

    2015-04-01

    Digital technology has the potential to transform mental healthcare by connecting patients, services and health data in new ways. Digital online and mobile applications can offer patients greater access to information and services and enhance clinical management and early intervention through access to real-time patient data. However, substantial gaps exist in the evidence base underlying these technologies. Greater patient and clinician involvement is needed to evaluate digital technologies and ensure they target unmet needs, maintain public trust and improve clinical outcomes. Royal College of Psychiatrists.

  8. Harnessing New Technologies: A Virtual World for Science Education?

    Science.gov (United States)

    Hainsworth, Mark

    2012-01-01

    The way in which the Internet and related technologies have exploded in the last few years is something that no one in education can ignore. Primary school pupils are already more technologically savvy than their parents and they expect their lessons to be exciting, interactive and driven by some aspect of technology. And so they should be. These…

  9. ATLAS@Home: Harnessing Volunteer Computing for HEP

    CERN Document Server

    Cameron, David; The ATLAS collaboration

    2015-01-01

    The ATLAS collaboration has setup a volunteer computing project called ATLAS@home. Volunteers running Monte-Carlo simulation on their personal computer provide significant computing resources, but also belong to a community potentially interested in HEP. Four types of contributors have been identified, whose questions range from advanced technical details to the reason why simulation is needed, how Computing is organized and how it relates to society. The creation of relevant outreach material for simulation, event visualization and distributed production will be described, as well as lessons learned while interacting with the BOINC volunteers community.

  10. Action Plan for Harnessing Science and Technology towards ...

    Indian Academy of Sciences (India)

    ... Year Meetings · Discussion Meetings · Public Lectures · Lecture Workshops · Refresher Courses · Symposia. Home; Fellowship. Fellow Profile. Elected: 1951 Section: Medicine. Viswanathan, Dharmavodani Krishnaiyar FNA. Date of birth: 1 March 1901. Date of death: 27 March 1960. Specialization: Public Health, Malaria.

  11. Harnessing Photovoice for tuberculosis advocacy in Karachi, Pakistan.

    Science.gov (United States)

    Mohammed, Shama; Sajun, Sana Zehra; Khan, Faisal S

    2015-06-01

    In Pakistan, despite publically available free testing and treatment throughout the country, there were an estimated 58,000 deaths due to tuberculosis in 2010. Understanding the experiences of people affected by TB is essential in addressing barriers to effective treatment. The Indus Hospital used Photovoice to understand the experiences of people affected by TB in Karachi. Two hundred and thirty photographs and stories were collected from 55 people affected by TB. Five major themes and 12 sub-themes emerged from the data: the physical aspects of TB (weakness and the side effects of the medication), the social aspects of TB (loneliness, stigma, and the fear/guilt of infecting family members), the socio-economic aspects of TB (financial difficulties/poverty and poor living conditions), supportive factors during treatment (support from family and friends, support from welfare organizations, prayer, visiting peaceful places), and recovery (happiness about getting better). The photographs, stories, and a Call for Action were shared at a Gallery event with patients, practitioners, and policy-makers. This study provides a look at the complexities surrounding TB and emphasizes the need for holistic interventions for TB that address all aspects of the disease, including its social determinants. It also highlights the potential of Photovoice as an effective means to bring much-needed attention to this disease. © The Author (2013). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  12. ATM: The Key To Harnessing the Power of Networked Multimedia.

    Science.gov (United States)

    Gross, Rod

    1996-01-01

    ATM (Asynchronous Transfer Mode) network technology handles the real-time continuous traffic flow necessary to support desktop multimedia applications. Describes network applications already used: desktop video collaboration, distance learning, and broadcasting video delivery. Examines the architecture of ATM technology, video delivery and sound…

  13. Action Plan for Harnessing Science and Technology towards ...

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1975 Section: Chemistry. Dhar, Dr Moti Lal Ph.D. (London), FNA, FNASc. Date of birth: 29 October 1914. Date of death: 20 January 2002. Specialization: Medicinal Chemistry Address: B-1, Pamposh Enclave, Greater Kailash-1, New Delhi 110 048. YouTube · Twitter · Facebook ...

  14. Harnessing Neuroplasticity to Promote Rehabilitation: CI Therapy for TBI

    Science.gov (United States)

    2015-10-01

    Direct Cost: $65,217 The aim of this study is to develop a customized physical activity, nutrition and behavioral intervention for obese adults with...behavioral neuroscience and behavioral psychology . Each of the members of the family has four main components: (a) extensive, intensive training; (b...organization of the training following shaping principles, a well-known method in psychology for teaching new behaviors; (c) constraint of compensatory

  15. Harnessing demographic change for economic growth in Africa ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-05-04

    May 4, 2016 ... Public health and education consumption profiles show that the government is already pursuing policies to increase the prospects of future higher demographic dividends by investing in improving child mortality rates, reproductive health, discouraging child marriage and delaying first pregnancy, and ...

  16. Harnessing Neuroplasticity to Promote Rehabilitation: CI Therapy for TBI

    Science.gov (United States)

    2016-10-01

    environment to gather data on the long-term safety and effectiveness of the RNS System at qualified Comprehensive Epilepsy Centers by qualified... epigenetics (Ver Hoef, PI) 0.6 calendar months Stephanie Mitchell National Institutes of Health, NINDS 6001 Executive Boulevard, Room 8184, MSC 9537...and built environment microbiomes, through longitudinal characterization of cohabitation in human populations. Aim 1. Quantify the impact of

  17. Harnessing the apoptotic programs in cancer stem-like cells.

    Science.gov (United States)

    Wang, Ying-Hua; Scadden, David T

    2015-09-01

    Elimination of malignant cells is an unmet challenge for most human cancer types even with therapies targeting specific driver mutations. Therefore, a multi-pronged strategy to alter cancer cell biology on multiple levels is increasingly recognized as essential for cancer cure. One such aspect of cancer cell biology is the relative apoptosis resistance of tumor-initiating cells. Here, we provide an overview of the mechanisms affecting the apoptotic process in tumor cells emphasizing the differences in the tumor-initiating or stem-like cells of cancer. Further, we summarize efforts to exploit these differences to design therapies targeting that important cancer cell population. © 2015 The Authors.

  18. Ecological intensification: harnessing ecosystem services for food security

    NARCIS (Netherlands)

    Bommarco, R.; Kleijn, D.; Potts, S.G.

    2013-01-01

    Rising demands for agricultural products will increase pressure to further intensify crop production, while negative environmental impacts have to be minimized. Ecological intensification entails the environmentally friendly replacement of anthropogenic inputs and/or enhancement of crop

  19. Ecological intensification: harnessing ecosystem services for food security.

    Science.gov (United States)

    Bommarco, Riccardo; Kleijn, David; Potts, Simon G

    2013-04-01

    Rising demands for agricultural products will increase pressure to further intensify crop production, while negative environmental impacts have to be minimized. Ecological intensification entails the environmentally friendly replacement of anthropogenic inputs and/or enhancement of crop productivity, by including regulating and supporting ecosystem services management in agricultural practices. Effective ecological intensification requires an understanding of the relations between land use at different scales and the community composition of ecosystem service-providing organisms above and below ground, and the flow, stability, contribution to yield, and management costs of the multiple services delivered by these organisms. Research efforts and investments are particularly needed to reduce existing yield gaps by integrating context-appropriate bundles of ecosystem services into crop production systems. Copyright © 2012 Elsevier Ltd. All rights reserved.

  20. Harnessing Internet finance with innovative cyber credit management

    National Research Council Canada - National Science Library

    Lin, Zhangxi; Whinston, Andrew B; Fan, Shaokun

    2015-01-01

    .... Applying the exploratory research approach, we investigate major innovative Internet-based financial services and classify them into five categories, as of e-commerce, e-payment, e-money market...