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Sample records for wegener granulomatosis computerized

  1. Wegeners Granulomatosis

    International Nuclear Information System (INIS)

    Canas Davila, Carlos Alberto; Restrepo Suarez, Jose Felix; Iglesias Gamarra, Antonio

    2001-01-01

    To review the recent medical literature with regard to the etiopathogenic and clinical aspects of the Wegeners Granulomatosis (WG), We carried out a search in the Medline database (1990-2000) that comprises topics related with etiology, epidemiology, pathology, and clinical aspect of WG. 650 abstracts were studied, finding that 125 of them informed topics related with the topic that we wanted to study. Then we got the articles. Some bibliographical references of these articles were considered fundamental for our objectives and we decided to get it too. The articles were classified according to their objectives and execution strategies, as they were revisions, original articles or cases report. We proceeded to their reading and analysis, for the later elaboration of the revision. We made a selection of information based in the following model: definition, history, epidemiology, etiopathogenesis, pathology, clinical aspects, course and evolution, diagnosis criteria, activity markers and treatment. WG is an infrequent disease The pathogenic and the therapeutic aspects are motives of recent and important advances in the medicine research, specially the state of the knowledge of antineutrophil cytoplasmic antibodies (ANCAs) and therapeutic tools which had decrease the mortality of this disease

  2. Wegener's Granulomatosis

    Science.gov (United States)

    ... male predominance. Granulomatosis with Polyangiitis typically occurs in middle age, but is found in people of all ages. ... with Polyangiitis in the upper respiratory tract. What’s New in Granulomatosis with Polyangiitis? In the past few ...

  3. Wegener's granulomatosis in childhood

    International Nuclear Information System (INIS)

    McHugh, K.; Manson, D.; Eberhard, B.A.; Shore, A.; Laxer, R.M.

    1991-01-01

    The authors reviewed the medical histories and radiological examinations of five pediatric patients with a histologic diagnosis of Wegener's granulomatosis (WG) seen over a six year period in whom a total of 22 thoracic CT scans were performed. Involvement of both the upper and lower respiratory tracts was seen in all patients at presentation. One patient had subglottic stenosis necessitating tracheotomy. Pulmonary hemorrhage occurred in three patients at initial diagnosis. Classic cavitary lung nodules were seen in two patients - one at initial presentation, the other at relapse. The plain radiographic lower respiratory tract manifestations of pediatric WG were protean both at initial presentation and during follow up. Similarly, disease expression was highly variable on thoracic CT examinations but, overall multifocal parenchymal infiltrates with or without small peripheral nodules were the commonest thoracic CT manifestations. As a consequence of cytotoxic and corticosteroid therapy the long-term prognosis of WG has improved considerably in recent years. Knowledge of the varied patterns of the primary disease and potential for iatrogenic complications are necessary for successful radiologic assessment of pediatric patients with WG. (orig.)

  4. Sinonasal Wegener's granulomatosis: CT characteristics

    International Nuclear Information System (INIS)

    Benoudiba, F.; Marsot-Dupuch, K.; Rabia, Hadj M.; Lasjaunias, P.; Cabanne, J.; Bobin, S.

    2003-01-01

    Wegener's granulomatosis (WG) is a severe and potentially lethal granulomatosis. Even though no specific radiological criteria exist, CT may suggest the correct diagnosis at an early stage. Recent improvement in the prognosis is related to earlier diagnosis, allowing the initiation of efficient and specific treatment before any severe complications occur. We reviewed a series of WG cases in order to establish the CT diagnostic criteria. (orig.)

  5. CT analysis of pulmonary Wegener's granulomatosis

    International Nuclear Information System (INIS)

    Liao Hualing; Chen Jianbo; Zhong Wenchen; Chen Jingdi

    2010-01-01

    Objective: To study the CT features and to improve the diagnostic accuracy of pulmonary Wegener's granulomatosis. Methods: 11 patients with histopathologically and clinically proven Wegener's granulomatosis were included in the study. Chest radiography was performed in all 11 patients and 8 patients underwent chest CT. Results: Lung abnormalities were noted in 10/11 patients including patchy lung opacities (n=3), multiple nodules (less than 3 cm in diameter, n=4), masses (more than 3cm in diameter, n=3), and cavitations (n=8). Multiple findings were observed in 4 patients. Conclusion: Imaging manifestations of pulmonary Wegener's granulomatosis were variable. Patchy lung opacities, nodules and cavitation were most common. Thin-walled cavity and ring-shaped cavity were characteristic. Pneumonia, abscess, tuberculosis and carcinoma should be included in the differential diagnosis. (authors)

  6. CT study of intracionial Wegener's Granulomatosis

    International Nuclear Information System (INIS)

    Yago, M.D.; Torres, T.; Martinez, G.; Lopez, A.; Barrena, R.

    1995-01-01

    Wegener granulamatosis is a multi systemic necrotizing granulomatous vasculitis distinguished from others by its predilection to affect the respiratory tract and the kidneys. Nervous system involvement occurs in 25% of cases, and the most common neurological manifestation is mono neuritis multiplex. However, primary affectation of CNS in an unusual manifestation. We report a case of Wegener Granulomatosis with almost unique neurological manifestation. CT imaging findings of meningeal involvement and retro-orbital pseudotumor are presented. 12 refs

  7. Diagnostic Consideration for Sinonasal Wegener's Granulomatosis Clinically Mistaken for Carcinoma

    Science.gov (United States)

    La Rosa, Cristina; Emmanuele, Carmela; Tranchina, Maria Grazia; Ippolito, Massimo; Cosentino, Sebastiano; Saita, Vincenzo; Fraggetta, Filippo

    2013-01-01

    We report a case of Wegener's granulomatosis clinically mistaken for carcinoma in a 21-year-old girl presenting with an ulcerated mass of the nasopharynx associated with enlarged laterocervical nodes. The lesion was clinically suspected as malignant on the basis of clinical and radiological findings (namely, computed tomography scan and positron emission tomography). However, multiple biopsies were not conclusive for malignancy showing histological change suggestive of Wegener's granulomatosis. A serum determination of cANCA supported the diagnosis of Wegener's granulomatosis. Clinical findings and image studies suggested an erroneous diagnosis of malignancy whereas a definitive diagnosis of Wegener's granulomatosis was achieved only after repeated biopsies thus leading to a correct therapeutic approach. The Wegener granulomatosis must be added to the list of the differential diagnoses of the masses of the nasopharynx associated with or without enlarged laterocervical nodes. PMID:24106630

  8. Wegener's granulomatosis occurring de novo during pregnancy.

    Science.gov (United States)

    Alfhaily, F; Watts, R; Leather, A

    2009-01-01

    Wegener's granulomatosis (WG) is rarely diagnosed during the reproductive years and uncommonly manifests for the first time during pregnancy. We report a case of de novo WG presenting at 30 weeks gestation with classical symptoms of WG (ENT, pulmonary). The diagnosis was confirmed by radiological, laboratory, and histological investigations. With a multidisciplinary approach, she had a successful vaginal delivery of a healthy baby. She was treated successfully by a combination of steroids, azathioprine and intravenous immunoglobulin in the active phase of disease for induction of remission and by azathioprine and steroids for maintenance of remission. The significant improvement in her symptoms allowed us to continue her pregnancy to 37 weeks when delivery was electively induced. Transplacental transmission of PR3-ANCA occurred but the neonate remained well. This case of de novo WG during pregnancy highlights the seriousness of this disease and the challenge in management of such patients.

  9. Bronchoplastic procedure for an unusual indication--Wegener's granulomatosis.

    LENUS (Irish Health Repository)

    Soo, Alan

    2009-09-01

    Wegener\\'s granulomatosis (WG) is a systemic vasculitic condition that commonly affects the lung and kidneys. With improvement in medical therapy, airway complications are increasingly encountered and are difficult to manage. Here, we present a case whereby a patient presenting with airway complication is successfully treated with surgery.

  10. Fulminant Wegener's granulomatosis: A case report

    Directory of Open Access Journals (Sweden)

    Dinić Miroslav Ž.

    2013-01-01

    Full Text Available Introduction. Granulomatosis Wegener is anti-neutrophil cytoplasmic antibodies (ANCAs-associated systemic vasculitis of unknown etiology. It is manifested as granulomatous necrotizing inflammation of the upper and lower parts of the respiratory tract, glomerulonephritis and systemic vasculitis involving most frequently the skin and oral mucous membrane. Sera markers of this disease are c-ANCA and p-ANCA. Case report. We presented a female patient aged 52 years with purpuric spots that had appeared on the lower legs ten months before admission to our hospital. The disease ran an aggressive course, and a month before admission hemorrhagic bullae, skin ulcers, hoarseness, dyspnea, generalized arthralgia, fatigue and fever had rapidly developed. Histopathological examination of a skin sample revealed necrotizing vasculitis, so that sera markers concentrations were elevated (c-ANCA, p-ANCA. There was a perforation of the nasal septum found on rhinoscopy. During hospitalization acute abdominal pain occurred, a possible tumor in the small intestine and possible granulomas in the liver were seen by multislice computed tomography (MSCT examination, with normal findings on the lungs and kidneys. The treatment started with methylprednisolone: 500 mg/d i.v. infusion for consecutive 3 days, then 60 mg/d. On exploratory laparotomy small bowel perforation and diffuse peritonitis were found. Unstable in the postoperative period, the patient died on the day 12 of hospitalization. Conclusion. The reported patient was with fulminant Wegener’s granulomatosis, dominantly with skin changes and with gastrointestinal manifestation. This case accents the need for rapid systemic clinical evaluation in a severely ill patient with unclear diagnosis.

  11. Chest CT findings in pediatric Wegener's granulomatosis

    International Nuclear Information System (INIS)

    Levine, Daniel; Akikusa, Jonathan; Manson, David; Silverman, Earl; Schneider, Rayfel

    2007-01-01

    Although pulmonary involvement occurs in the majority of children and adolescents with Wegener's granulomatosis (WG), relatively little has been published regarding the CT imaging manifestations in this group of patients. To determine the frequency and types of chest CT abnormalities in active pediatric WG (pWG). The study was a retrospective examination of 29 chest CT examinations performed at diagnosis (n=14) and during disease flares (n=15) in 18 children. The most common abnormalities were nodules (seen in 90% of examinations), ground-glass opacification (52%), and air-space opacification (45%). Of examinations with nodules, 73% demonstrated nodules >5 mm in diameter and 69% demonstrated more than five nodules; 17% had cavitary lesions. The only abnormality with a significant difference in prevalence between diagnosis and disease flares was air-space opacification, present in 71% and 20%, respectively (P < 0.01). In accordance with the findings of published adult studies and at variance with those of prior pediatric studies, our findings indicate that chest CT abnormalities in active pWG are frequent, most commonly comprising nodules and ground-glass opacification, which may be difficult to detect on plain radiography. We therefore advocate the routine use of chest CT for all affected patients, both at the time of presentation and during disease flares. (orig.)

  12. Sinonasal Wegener's granulomatosis: CT characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Benoudiba, F.; Marsot-Dupuch, K.; Rabia, Hadj M.; Lasjaunias, P. [Neuroradiology Department, Bicetre Hospital, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre (France); Cabanne, J. [Department of Internal Medecine, Saint-Antoine Hospital, 184 rue du Faubourg Saint-Antoine, 75012 Paris (France); Bobin, S. [Head and Neck Department, Bicetre Hospital, 78, rue du General Leclerc, 94275 Le Kremlin Bicetre (France)

    2003-02-01

    Wegener's granulomatosis (WG) is a severe and potentially lethal granulomatosis. Even though no specific radiological criteria exist, CT may suggest the correct diagnosis at an early stage. Recent improvement in the prognosis is related to earlier diagnosis, allowing the initiation of efficient and specific treatment before any severe complications occur. We reviewed a series of WG cases in order to establish the CT diagnostic criteria. (orig.)

  13. Infections and Wegener's granulomatosis - A cause and effect relationship?

    NARCIS (Netherlands)

    George, J; Levy, Y; Kallenberg, CGM; Shoenfeld, Y

    The association of infections and autoimmune disease has been noted by various authors. Several mechanisms have been proposed to explain this, with no current consensus. Wegener's granulo-matosis (WG) is an autoimmune disease involving predominantly the pulmonary and renal systems, and is associated

  14. Incidence of granulomatosis with polyangiitis (Wegener`s) in Greenland and the Faroe Islands

    DEFF Research Database (Denmark)

    Faurschou, M; Helleberg, M; Obel, N

    2013-01-01

    Previous studies suggest that the incidence of granulomatosis with polyangiitis (Wegener's; GPA) increases along a south-north gradient in the Northern Hemisphere with an incidence of 8.0/million/year reported for the population of Northern Norway. In the present study, we assessed the incidence ...

  15. Thoracic manifestation of Wegener's granulomatosis: CT findings in 30 patients

    International Nuclear Information System (INIS)

    Lee, Kyung Soo; Kim, Tae Sung; Kim, Eun A.; Fujimoto, Kiminori; Moriya, Hiroshi; Watanabe, Hideyuki; Tateishi, Ukihide; Ashizawa, Kazuoto; Johkoh, Takeshi; Kwon, O. Jung

    2003-01-01

    Our objective was to describe the CT findings of thoracic Wegener's granulomatosis. At presentation, both conventional and thin-section CT scans were available in 30 patients with Wegener's granulomatosis. Serial CT scans (range of intervals: 1-25 months, mean 4.5 months) were available in 20 patients. The initial and follow-up CT scans were analyzed retrospectively by two observers in terms of pattern and extent of parenchymal and airway lesions. Positive CT findings were seen in 29 of 30 (97%) patients at initial presentation. The most common pattern was nodules or masses seen in 27 of 30 (90%) patients. They were multiple in 23 of 27 (85%) patients, bilateral in 18 (67%), subpleural in 24 (89%), and peribronchovascular in 11 (41%) in distribution. Bronchial wall thickening in the segmental or subsegmental bronchi was seen in 22 (73%) patients. Large airways were also abnormal in 9 (30%) patients. Patchy areas of consolidation and ground-glass opacity were seen in 7 (23%) patients, respectively. In 17 of 20 (85%) patients in whom follow-up CT scans were available, the parenchymal or airway lesion showed complete or partial improvement with treatment. The CT findings of Wegener's granulomatosis, although multiple and variable, consist mainly of bilateral subpleural or peribronchovascular nodules or masses and bronchial wall thickening in the segmental or subsegmental bronchi. Parenchymal and airway lesions improve with treatment in most patients. (orig.)

  16. An atypical case of Wegener's granulomatosis complicated by sepsis and coxitis

    International Nuclear Information System (INIS)

    Makowski, A.; Faflik, J.

    1993-01-01

    There is presented an atypical case Wegener's granulomatosis of maxillo-nasal region without bony destruction. The case is unusual because of sepsis and purulent coxitis. The patient responded well to treatment with vincristine and cyclophosphamide. ANCA (anti-neutrophil cytoplasmic antibodies) assays have very good sensitivity and specificity for Wegener's granulomatosis. (author)

  17. Asymptomatic appearance of splenic infarction in Wegeners granulomatosis

    International Nuclear Information System (INIS)

    Martusewicz-Boros, M.; Roszkowski-Sliz, K.; Wiatr, E.; Baranska, I.; Bestry, I.

    2011-01-01

    Splenic involvements in Wegeners granulomatosis (WG) are rarely diagnosed ante-mortem, while an autopsy is able to reveal a high rate of spleen lesions (78 - 100%). To date, there have been a few reported cases of splenic abnormalities in WG, including: splenomegaly, capsular adhesion, dysfunction and infarction. We reported a case of biopsy-verified WG with radiological evidence of diffuse spleen infarction despite the lack of any clinical symptoms. We concluded that due to a potential risk of severe hemorrhagic complications when anticoagulant therapy is necessary, radiological assessment of spleen should be performed regularly in this group of patients, particularly because spleen involvement can be asymptomatic. (authors)

  18. Polyangiitis overlap syndrome of granulomatosis with polyangiitis (Wegener's granulomatosis) and eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome).

    Science.gov (United States)

    Uematsu, Hironori; Takata, Shohei; Sueishi, Katsuo; Inoue, Hiromasa

    2014-02-27

    Polyangiitis overlap syndrome is defined as systemic vasculitis that cannot be classified into one of the well-defined vasculitic syndromes. In this report, a female patient who presented with vasculitis-like and asthmatic symptoms was diagnosed as having polyangiitis overlap syndrome of granulomatosis with polyangiitis (GPA; formerly known as Wegener's granulomatosis) and eosinophilic granulomatosis with polyangiitis (EGPA; formerly known as Churg-Strauss syndrome). The patient fulfilled the American College of Rheumatology diagnostic criteria for GPA and EGPA. She was successfully treated with immunosuppressants and steroids and has been in remission for 20 months. It is important to establish a proper diagnosis and introduce an appropriate treatment modality in patients with this rare and serious pathology to prevent irreversible organ damage.

  19. Pulmonary manifestations of wegener granulomatosis: CT findings in 57 patients and a review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Lohrmann, Christian; Uhl, Markus; Kotter, Elmar; Burger, Dieter; Ghanem, Nadir; Langer, Mathias

    2005-03-01

    Wegener granulomatosis is a multisystem disease of unknown cause characterized by a necrotizing granulomatous vasculitis. In comparison to other vasculitides, the lung is the most common organ involved in wegener granulomatosis presenting with a very aggressive airways pathology and chronic relapsing course. Chest radiographs fail to describe the pattern and distribution of thoracic pathology sufficiently, and CT has shown to be more sensitive for detecting lung involvement. We present the CT findings of 57 patients with wegener granulomatosis and a review of the literature.

  20. Wegener's granulomatosis. Report of five cases and revision of the literature

    International Nuclear Information System (INIS)

    Pedrozo Pupo, John C; Ortiz Ruiz, Guillermo; Ojeda Leon, Paulina; Carrillo Bayona, Jorge

    2001-01-01

    We describe the wegener's granulomatosis is illustrated by 5 case reports. Wegener's granulomatosis is a rare disease of unknown etiology, is characterized histologically by a necrotizing granulomatous vasculitis that most commonly involves the lungs together with the nasal pathways, paranasal sinuses, and kidneys, but may affect any organ system. There is increasing recognition of early forms of wegener's granulomatosis with limited disease extension an low activity. Treatment with cyclophosphamide and corticosteroids suppresses disease activity and results in long-term. Remissions. C-antineutrophil cytoplasmic antibodies and acute-phase reactants are helpful in monitoring overall activity, but they do not reflect the manifestation of disease in specific organ systems

  1. Wegener granulomatosis as an uncommon cause of panhypopituitarism in childhood.

    Science.gov (United States)

    Kara, Ozlem; Demirel, Fatma; Acar, Banu Celikel; Cakar, Nilgün

    2013-01-01

    Wegener granulomatosis (WG) is a cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA)-associated, multi-system, necrotizing granulomatous vasculitis. Inflammation of the nasal or oral mucosa, and lung and kidney involvements are typical in the course of the disease. In rare cases, pituitary involvement may occur and cause panhypopituitarism. Pituitary involvement is very rare, and only two pediatric case reports have been published to date out of a total of 24 cases. This is a case report of an adolescent patient who presented with panhypopituitarism symptoms and was later diagnosed with WG. A 16-year-old female patient complained of fever, headache, purulent nasal discharge and severe muscle and joint pain. Additionally, she had polyuria and polydipsia. Investigations revealed a pituitary mass and panhypopituitarism. Positivity of c-ANCA and renal biopsy result compatible with WG confirmed the diagnosis.

  2. Wegener's granulomatosis: chest computed tomography findings; Granulomatose de Wegener: aspectos na tomografia computadorizada de torax

    Energy Technology Data Exchange (ETDEWEB)

    Monteiro, Evelise de Azevedo; Marchiori, Edson; Martins, Erick Malheiro Leoncio [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Dept. de Radiologia]. E-mail: edmarchiori@zipmail.com.br; Souza Junior, Arthur Soares [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Hospital de Base; Cerqueira, Elza Maria F.P. de [Universidade Estadual de Campinas, SP (Brazil). Faculdade de Ciencias Medicas. Dept. de Radiologia; Irion, Klaus L. [Pavilhao Pereira Filho, Porto Alegre, RS (Brazil); Araujo Neto, Cesar de [Bahia Univ., Salvador, BA (Brazil). Dept. de Radiologia; Souza, Rodrigo Azeredo de [Universidade Federal, Rio de Janeiro, RJ (Brazil). Faculdade de Medicina. Dept. de Radiologia

    2003-03-01

    Wegeners granulomatosis is an inflammatory systemic necrotizing idiopathic vasculitis affecting mainly small vessels. In this paper we analyzed the computed tomography findings of seven patients with Wegeners granulomatosis. The most common findings were masses and nodules (71.4%), areas of ground glass attenuation (57.1%), consolidation (42.8%), halo sign (42.8%), cavitation (42.8%), interlobular septa thickening (14.2%), bronchial wall thickening (14.2%) and pleural effusion (14.2%). Although radiological findings are mostly nonspecific, computed tomography and particularly high-resolution computed tomography are important tools in the evaluation of disease activity when evaluated in association with bronchoscopy findings and clinical data. (author)

  3. Massive Alveolar Hemorrhage During Wegener Granulomatosis: a Case Report

    Directory of Open Access Journals (Sweden)

    Gökhan Perincek

    2011-11-01

    Full Text Available This is a presentation of Wegener Granulomatosis (WG disease. Even though the lungs are rarely affected. massive alveolar hemorrhage is seen which leads to mortality. The patient was a 28 year old man. His illness was diagnosed as WG and glomerulonephritis a year previously and he was treated by administration of methylprednisolone orally. He had been treated irregularly. He applied to the emergency service with hemoptysis and asthma complaints two days earlier. After the results of his examination Hb: 3.6 gr/dl, Htc:10.3%, Üre:131 mg /dl, kreatini: 7.7 mg/dl, pH: 7.41, pO2: 55 mmHg, pCO2:33 mmHg, and being diagnosed as alveolar consolidation on lung X-ray, he was taken to the intensive care unit with a diagnosis of a massive alveolar hemorrhagei. He was intubated and attached to mechanical ventilation. He was treated with parenteral 1 mg/kg/day methylprednisolone and, siklofosfamid 2 mg/kg/day. He was extubated on the 21st day. He was taken to the chest service department on 24th day. He is still being treated.

  4. Chest CT findings in pediatric Wegener's granulomatosis

    Energy Technology Data Exchange (ETDEWEB)

    Levine, Daniel [British Columbia Children' s Hospital, Department of Radiology and Nuclear Medicine, Vancouver, British Columbia (Canada); Akikusa, Jonathan [Royal Children' s Hospital Melbourne, Department of Rheumatology, Melbourne (Australia); Manson, David [Hospital for Sick Children, Department of Radiology, Toronto (Canada); Silverman, Earl; Schneider, Rayfel [Hospital for Sick Children, Department of Rheumatology, Toronto (Canada)

    2007-01-15

    Although pulmonary involvement occurs in the majority of children and adolescents with Wegener's granulomatosis (WG), relatively little has been published regarding the CT imaging manifestations in this group of patients. To determine the frequency and types of chest CT abnormalities in active pediatric WG (pWG). The study was a retrospective examination of 29 chest CT examinations performed at diagnosis (n=14) and during disease flares (n=15) in 18 children. The most common abnormalities were nodules (seen in 90% of examinations), ground-glass opacification (52%), and air-space opacification (45%). Of examinations with nodules, 73% demonstrated nodules >5 mm in diameter and 69% demonstrated more than five nodules; 17% had cavitary lesions. The only abnormality with a significant difference in prevalence between diagnosis and disease flares was air-space opacification, present in 71% and 20%, respectively (P < 0.01). In accordance with the findings of published adult studies and at variance with those of prior pediatric studies, our findings indicate that chest CT abnormalities in active pWG are frequent, most commonly comprising nodules and ground-glass opacification, which may be difficult to detect on plain radiography. We therefore advocate the routine use of chest CT for all affected patients, both at the time of presentation and during disease flares. (orig.)

  5. Strawberry gingivitis as the first presenting sign of wegener's granulomatosis: report of a case

    Science.gov (United States)

    2011-01-01

    Wegener's granulomatosis is a rare multi-system disease characterized by the classic triad of necrotizing granulomas affecting the upper and lower respiratory tracts, disseminated vasculitis and glomerulonephritis. Oral lesions as a presenting feature are only encountered in 2% of these cases. Hyperplastic gingival lesions or strawberry gingivitis, is a characteristic sign of Wegener's granulomatosis. The latter consists of reddish-purple exophytic gingival swellings with petechial haemorrhages thus resembling strawberries. Recognition of this feature is of utmost importance for timely diagnosis and definitive management of this potentially fatal disease. A case of strawberry gingivitis as the first presenting sign of Wegener's granulomatosis affecting a 50-year-old Malay male is reported here. The differential diagnosis of red lesions that may present in the gingiva is discussed. PMID:21813375

  6. [Subglottic stenosis as the initial manifestation of Wegener's granulomatosis in a teenager. Case report].

    Science.gov (United States)

    Cuestas, Giselle; Rodríguez, Verónica; Doormann, Flavia; Pringe, Alejandra; Bellia Munzón, Patricio; Bellia Munzón, Gastón; Ortega, Carlos; Álvarez, Rubén

    2017-04-01

    Wegener's granulomatosis is a necrotizing granulomatous vasculitis of autoimmune origin that primarily affects the upper and lower airways and kidneys. It is very rare in children and adolescents. When started at a young age it is often associated with subglottic stenosis. Subglottic stenosis is a potentially fatal manifestation of Wegener's granulomatosis. Its diagnosis requires a high index of suspicion since it might develop in the absence of other signs of activity. Occasionally, subglottic stenosis may present as the initial manifestation of the disease. Diagnosis is confirmed by endoscopic visualization of the lesion. The treatment is complex, and it often requires repeated interventions due to restenosis. We present a 13-year-old patient with subglottic stenosis secondary to Wegener's granulomatosis. We describe the clinical manifestations, diagnosis and treatment of this rare cause of respiratory distress in the pediatric population. Sociedad Argentina de Pediatría.

  7. Bilateral acute angle-closure glaucoma as a first presentation of granulomatosis with polyangiitis (Wegener's

    Directory of Open Access Journals (Sweden)

    Alper Mete

    Full Text Available ABSTRACT We report a case of bilateral acute angle-closure glaucoma in a patient with undiagnosed granulomatosis with polyangiitis (Wegener's. A 59-year-old man presented with a severe headache, ocular pain, blurred vision, shortness of breath, and mild fever. Clinical examination revealed conjunctival chemosis, corneal edema, and shallow anterior chambers. Closed angles were observed bilaterally on gonioscopy. The patient was treated with intravenous mannitol, oral acetazolamide, and anti-glaucomatous eye drops. Over the following two days, his vision improved and intraocular pressures decreased. Subsequently, laser iridotomies were performed bilaterally and the patient attended consultations with our departments of respiratory medicine, nephrology, and rheumatology and was subsequently diagnosed with granulomatosis with polyangiitis. Bilateral acute angle-closure glaucoma is a very rare ocular manifestation of granulomatosis with polyangiitis. The association of this clinical entity with Wegener's granulomatosis remains unknown.

  8. Wegener´s granulomatosis in a young patient preceded by localized cutaneous manifestations

    Directory of Open Access Journals (Sweden)

    Jesper Smit

    2011-10-01

    Full Text Available Wegener´s granulomatosis (WG is a rare, systemic vasculitis involving multiple organs. The clinical presentation is highly diverse, and there is considerable risk of mortality if diagnosis and treatment are delayed. We present a case illustrating that patients with WG may initially present with localized cutaneous symptoms and signs.

  9. Diversity of PR3-ANCA epitope specificity in Wegener's granulomatosis. Analysis using the biosensor technology

    NARCIS (Netherlands)

    Rarok, Agnieszka; van der Geld, Y.M.; Stegeman, Coen; Limburg, Piet; Kallenberg, Cees

    Wegener's granulomatosis is a systemic disease characterized by the presence of antineutrophil cytoplasm autoantibodies specific for proteinase 3 (PR3-ANCA). The functional characteristics of PR3-ANCA differ between quiescent and active disease, suggesting changes in the properties of the

  10. Expression of recombinant proteinase 3, the autoantigen in Wegener's granulomatosis, in insect cells

    NARCIS (Netherlands)

    Van der Geld, YM; Smook, MLF; Huitema, MG; Harmsen, MC; Limburg, PC; Kallenberg, CGM

    2002-01-01

    Proteinase 3 (PR3) is the major autoantigen for anti-neutrophil cytoplasmic antibodies (ANCA) in patients with Wegener's granulomatosis. Little is known about the major antigenic sites on PR3. To facilitate epitope mapping, PR3 was cloned in insect cells using a baculovirus expression system. Four

  11. Persistent expansion of CD4(+) effector memory T cells in Wegener's granulomatosis

    NARCIS (Netherlands)

    Abdulahad, W. H.; van der Geld, Y. M.; Stegeman, C. A.; Kallenberg, C. G. M.

    In order to test the hypothesis that Wegener's granulomatosis (WG) is associated with an ongoing immune effector response, even in remission, we examined the distribution of peripheral naive and memory T-lymphocytes in this disease, and analyzed the function-related phenotypes of the memory T-cell

  12. Functional defect of circulating regulatory CD4+T cells in patients with Wegener's granulomatosis in remission

    NARCIS (Netherlands)

    Abdulahad, Wayel Habib; Stegeman, Coen; van der Geld, Y.M.; Doornbos-van der Meer, B.; Limburg, Piet; Kallenberg, Cees

    Objective. Accumulating data support the role of regulatory T cells, a subset of CD4+ T cells that expresses CD25(high) and the transcription factor fork-head box P3 (FoxP3), in controlling and preventing autoimmunity. In Wegener's granulomatosis (WG), an autoimmune vasculitis, up-regulation of CD25

  13. [Morphological pathology of vessels in granulomatosis with polyangiitis (Wegener's disease)].

    Science.gov (United States)

    Zerbino, D D; Zimba, E A

    2015-01-01

    to investigate the incidence of injuries in different vascular beds and the morphopathological changes in vessels in granulomatosis with polyangiitis. The morphopathological features of vascular injuries were investigated in 11 dead patients aged 16--74 years with granulomatosis with polyangiitis. Proliferative and destructive angiitis with predominant involvement of microcirculatory vessels and with development of necrosis-prone granulomas in their walls and perivascularly was established to underlie the clinical manifestations of granulomatosis with polyangiitis. The most typical localization of the pathologic process is the vessels of the upper respiratory tract, lungs, and kidneys. Cardiopulmonary and renal failures are causes of death in the majority of cases. It should be noted that the vessels of the heart, liver, and gastrointestinal tract are frequently involved in the pathological process. Vascular changes in these organs determine the clinical features of granulomatosis with polyangiitis and lead to a number of fatal complications. Granulomatosis with polyangiitis is a systemic disease with polymorphism of clinical manifestations, which requires in-depth analysis based on current precision patient examination methods, including a histopathological study.

  14. T-cell mediated immunity in Wegener's granulomatosis

    NARCIS (Netherlands)

    Abdulahad, Wayel Habib

    2008-01-01

    Although the pathogenetic mechanisms involved in Wegener’s granulomatosis (WG) are not completely understood, considerable evidence support the concepts that activated T-cells play an important role in disease expression. It is, however, not clear which subsets of T-cells are involved in the

  15. Pulmonary CT findings of Wegener's granulomatosis (WG). Follow-up images and pathology

    International Nuclear Information System (INIS)

    Uezono, Haruka; Noma, Satoshi; Sakamoto, Ryo

    2009-01-01

    We reviewed 16 cases of Wegener's granulomatosis (WG) with regard to CT findings, PR3-ANCA, and clinical courses. Because of PR3-ANCA, atypical manifestations of WG could have been diagnosed, including tiny nodules without symptoms and self-remissions. Radiologists should be aware of these atypical manifestations of WG. Seeing multiple nodules in lung, WG should be included in the differential diagnosis and extrapulmonary manifestation of WG should be evaluated. (author)

  16. Granulomatose de Wegener: Envolvimento otológico, nasal, laringotraqueal e pulmonar Wegener granulomatosis: Otologic, nasal, tracheobronchial and pulmonary involvement

    Directory of Open Access Journals (Sweden)

    Sandra Figueiredo

    2009-10-01

    Full Text Available A granulomatose de Wegener é uma vasculite sistémica rara e idiopática caracterizada pelo atingimento dos pequenos vasos. A doença atinge, preferencialmente, as vias aérea superior e inferior e os rins, levando à formação de granulomas e necrose destes órgãos. As manifestações clínicas e o envolvimento orgânico variam largamente. O diagnóstico e tratamento precoce podem levar à recuperação total. No entanto, o atraso no diagnóstico pode ser fatal. Os autores apresentam o caso de uma doente de 33 anos com uma forma de apresentação grave e rara da doença, mas com uma evolução favorável após diagnóstico e tratamento adequado.Wegener granulomatosis is a rare systemic idiopathic disease characterized by involvement of small vessels - medium and small arteries, venules, arterioles and ocasionally large arteries. This disease has predilection for the upper and lower respiratory tract and the kidney, with granulomatous inflamation and necrosis. Clinical manifestations and organ involvement of the disease vary widely. Early diagnosis and treatment may lead to a full recovery. Without treatment, Wegener’s granulomatosis can be fatal. The authors present a case of a 33 year-old female, with severe disease, but with good outcome, after adequate diagnosis and treatment.

  17. Reversible complete atrioventricular block in patient with wegener's granulomatosis - a report on fortunate outcome with long term follow-up.

    Science.gov (United States)

    Steckiewicz, Roman; Rosiak, Marek; Stolarz, Przemysław; Świętoń, Elżbieta B; Grabowski, Marcin; Kosior, Dariusz A

    Reversible complete atrioventricular block in patient with Wegener's granulomatosis - a report on a positive outcome with long term follow-up. Atrioventricular (AV) block is a rare complication of Wegener's granulomatosis (WG), thus there are no standards of management in such cases. We present a case of a patient with a dual-chamber pacemaker (DDD) implanted due to complete AV block in the course of Wegener's granulomatosis (WG). An immunosuppressive therapy resulted in the resolution of non-cardiac and AV conduction disorders. The diagnostic functions of the pacemaker enabled us to evaluate AV conduction over a five-year follow-up period. The resolution of AV conduction disorders, which accompanied WG remission, suggests that careful monitoring with temporary cardiac pacing may be considered in some patients before permanent pacemaker implantation.

  18. Cranial nerve palsy in Wegener's granulomatosis--lessons from clinical cases

    DEFF Research Database (Denmark)

    Nowack, Rainer; Wachtler, Paul; Kunz, Jürgen

    2009-01-01

    The problem of diagnosing vasculitic neuropathy is discussed based on case reports of two patients with Wegener's granulomatosis. One patient developed de novo 6(th) nerve palsy as an isolated relapse manifestation and the second patient a sequence of multiple cranial nerve palsies. Brain imaging...... by the overall clinical presentations. Cranial neuropathy may be the first obvious vasculitic manifestation preceding other organ disease, and since single reliable tests for its diagnosis are lacking, a multidisciplinary approach is advocated here to detect vasculitic manifestations in other organs....

  19. Lingual infarction in Wegener's Granulomatosis: A case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Brizman Eitan

    2008-08-01

    Full Text Available Abstract Wegener's granulomatosis (WG is a multi-system disease, characterised by the triad of necrotising granulomata affecting the upper and lower respiratory tracts, disseminated vasculitis and glomerulonephritis. Oral lesions are associated with up to 50% of cases, although are rare as a presenting feature. The most common oral lesions associated with WG are ulceration and strawberry gingivitis. We review the literature regarding oral manifestations of WG and present a case of lingual infarction, an extremely rare oral lesion associated with WG, in a severe, rapidly progressive and ultimately fatal form of the disease.

  20. Plasma exchange for induction and cyclosporine A for maintenance of remission in Wegener's granulomatosis--a clinical randomized controlled trial

    DEFF Research Database (Denmark)

    Szpirt, Wladimir M; Heaf, James G; Petersen, Jørgen

    2011-01-01

    The use of plasma exchange (PE) for induction treatment of anti-neutrophil cytoplasm autoantibody (ANCA)-associated vasculitis (AAV), including Wegener's granulomatosis (WG), is still controversial. The use of PE in AAV is not commonly accepted in patients with a plasma creatinine...

  1. [A historic case of Wegener's granulomatosis: the physicist who discovered the electromagnetic waves: Heinrich Hertz].

    Science.gov (United States)

    Feldmann, H

    2005-06-01

    A diary and an extensive correspondence of Heinrich Hertz and his family provide a meticulous documentation of his life, made available by Albrecht Folsing in 1997 through a carefully investigated biography, which permit the conclusion that H. Hertz died of Wegener's granulomatosis, 45 years before this disease had been explored. WEGENER'S GRANULOMATOSIS: The symptoms of the granulomatosis, that was first described by Friedrich Wegener in 1936 and 1939 are presented in short with literal quotations of the author: It begins with a refractory cold that will last until the end, then follow involvement of the paranasal sinuses, ears, mucous lining of mouth and pharynx, slight fever, weakness, in the final phase dissemination with nephritis, septic fever, arthritis, myalgia, paralyses leading to total immobility, exitus. The etiology is not fully understood but probably based on immunoreaction. H. HERTZ: CURRICULUM VITAE: Born in Hamburg, Germany, in 1857: after secondary school academic training in physics at Dresden, Munic and Berlin. 1885 professor of physics in Karlsruhe, then starting in 1889 at Bonn. 1887/88 exploration of the electromagnetic waves, now the basis for all radio communication, and exploration of the photoelectric effect, the basis of solar techniques. Numerous highranking distinctions. H. HERTZ: The case history is presented in detail based on numerous literal quotations from personal letters and the diary. After a few banal affections involving the teeth and toes the systemic disease became manifest in summer 1892 with a refractory cold which remained the focus of treatment until death. Granulation tissue in the nose that was excised several times: no tuberculosis, no carcinoma. Otitis with purulent mastoiditis, in October 1892 mastoidectomy, persistent purulence. Early in 1893 diagnosis of nephritis. Extraction of a superior tooth, punturing of the maxillary sinus, then twice radical opening of the maxillary sinus. Painful ankylosis and paralyses

  2. Subglottic stenosis in granulomatosis with polyangiitis (Wegener's granulomatosis): Report of 4 cases.

    Science.gov (United States)

    Horta-Baas, Gabriel; Hernández-Cabrera, María Fernanda; Catana, Rocío; Pérez-Cristóbal, Mario; Barile-Fabris, Leonor Adriana

    2016-01-01

    Subglottic stenosis (SGS) in granulomatosis with polyangiitis (GPA) may result from active disease or from chronic recurrent inflammation. The objective of the study was to describe the clinical features and treatment of patients with subglottic stenosis. We retrospectively reviewed the medical records of all patients with SGS due to GPA diagnosed at Rheumatology deparment between January 2000 and June 2015. We present 4 cases of SGS at our department during a period of 15 years. The interval between the presentation of the GPA and SGS varied between 2 and 144 months. The leading symptoms of SGS were dyspnoea on exertion and stridor. Three patients presented SGS without evidence of systemic activity. Two patients presented SGS grade i and received tracheal dilatation; two recurred and three needed a tracheostomy due to severe airway-limiting stenosis. SGS presents high morbidity. Even though subglottic dilatation provides symptomatic relief, recurrences may present. Severe airway-limiting stenosis often requires tracheostomy. Copyright © 2015 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.

  3. Assessment of the Item Selection and Weighting in the Birmingham Vasculitis Activity Score for Wegener's Granulomatosis

    Science.gov (United States)

    MAHR, ALFRED D.; NEOGI, TUHINA; LAVALLEY, MICHAEL P.; DAVIS, JOHN C.; HOFFMAN, GARY S.; MCCUNE, W. JOSEPH; SPECKS, ULRICH; SPIERA, ROBERT F.; ST.CLAIR, E. WILLIAM; STONE, JOHN H.; MERKEL, PETER A.

    2013-01-01

    Objective To assess the Birmingham Vasculitis Activity Score for Wegener's Granulomatosis (BVAS/WG) with respect to its selection and weighting of items. Methods This study used the BVAS/WG data from the Wegener's Granulomatosis Etanercept Trial. The scoring frequencies of the 34 predefined items and any “other” items added by clinicians were calculated. Using linear regression with generalized estimating equations in which the physician global assessment (PGA) of disease activity was the dependent variable, we computed weights for all predefined items. We also created variables for clinical manifestations frequently added as other items, and computed weights for these as well. We searched for the model that included the items and their generated weights yielding an activity score with the highest R2 to predict the PGA. Results We analyzed 2,044 BVAS/WG assessments from 180 patients; 734 assessments were scored during active disease. The highest R2 with the PGA was obtained by scoring WG activity based on the following items: the 25 predefined items rated on ≥5 visits, the 2 newly created fatigue and weight loss variables, the remaining minor other and major other items, and a variable that signified whether new or worse items were present at a specific visit. The weights assigned to the items ranged from 1 to 21. Compared with the original BVAS/WG, this modified score correlated significantly more strongly with the PGA. Conclusion This study suggests possibilities to enhance the item selection and weighting of the BVAS/WG. These changes may increase this instrument's ability to capture the continuum of disease activity in WG. PMID:18512722

  4. Granulomatosis de Wegener Semejando Cáncer Epidermoide de Nasofaringe y Metástasis Pulmonares.

    Directory of Open Access Journals (Sweden)

    Gustavo Adolfo Martín Small

    2011-01-01

    Full Text Available La granulomatosis de Wegener (GW es una enfermedad idiopática, con posible componente autoinmune, que aparece generalmente en la quinta década de vida, caracterizándose por lesiones granulomatosas necrotizantes y vasculitis en vías aéreas y riñón. Paciente femenino de 54 años, quien desde Noviembre del 2008, presenta rinorrea, prurito y eritema en borde nasal inferior izquierdo, recibe antibióticos sin mejoría de los síntomas. En las radiografías torácicas, se observan dos radiopacidades redondeadas, de 4 cm de diámetro, sugestivas de lesiones tumorales en ambos campos pulmonares. La biopsia reporta cáncer epidermoide de alto grado, sospechándose primario en nasofaringe. Es remitida, por deterioro de condiciones, al Servicio de Neumonología del Hospital Universitario de Caracas el 18/03/2009, presentando disnea, tos productiva, placas purpúricas dolorosas en manos y pies, hipoacusia, hiperpigmentación del paladar duro, leucoplaquias y lesiones costrosas en lengua, insuficiencia renal (creatinina en 6,11 mg/dL y trombocitopenia. En TAC de tórax, se evidencian tumores mayores de 5 cm de diámetro, algunos con bordes bien definidos y otros mal delimitados con broncograma aéreo. Diagnostico definitivo de GW por serología. La GW con su afectación sistémica puede simular otras entidades como neoplasias de cabeza y cuello con metástasis pulmonares. Cuando las manifestaciones sistémicas son floridas debe sospecharse GW como diagnóstico diferencial. Palabras claves: Wegener, Granulomatosis, Vasculitis, Cáncer epidermoide.

  5. [Surgical treatment with dacryocystitis and retinal detachment in a patient with Wegener granulomatosis].

    Science.gov (United States)

    Metoki, Tomomi; Kubo, Masabumi; Takano, Yoshiko; Nakamura, Hideo; Nakazawa, Mitsuru

    2003-06-01

    We report surgical treatment of a patient with dacryocystitis and retinal detachment (RD), which are rare ophthalmic involvements of Wegener granulomatosis (WG). The patient was a 26-year-old man with WG. He was diagnosed as having WG 4 years ago and he has been treated by maintenance doses of predonisolone and cyclophosphamide. Rheumatoid factor and serum antinuclear antibody were negative. Cytoplasmic pattern-antineutrophil cytoplasmic antibody (C-ANCA) and renal function were normal. He was found to have nasolacrimal duct obstruction and lattice degeneration bilaterally, retinal tear with RD in the left eye and tear without RD in the right eye. No sign of vasculitis was found in fluorescein angiography. Bilateral dacryocystorhinostomy was performed without any sign of postoperative necrosis of the wound. After the surgery, epiphora and eye discharge disappeared and lacrimal passage has been maintained without obstruction. The pathological findings of his nasal mucosa and lacrimal sac showed chronic inflammation and no typical changes of WG. There was no abnormal change in the conjunctiva and sclera after an uncomplicated scleral buckling surgery. We conclude that operations such as dacryocystorhinostomy and scleral buckling surgery may be performed successfully when WG is controlled within the normal limits of C-ANCA.

  6. Epidemiology of granulomatosis with polyangiitis (Wegener's granulomatosis) in Northern Italy: a 15-year population-based study.

    Science.gov (United States)

    Catanoso, Mariagrazia; Macchioni, Pierluigi; Boiardi, Luigi; Manenti, Lucio; Tumiati, Bruno; Cavazza, Alberto; Luberto, Ferdinando; Pipitone, Nicolò; Salvarani, Carlo

    2014-10-01

    To investigate the epidemiology of granulomatosis with polyangiitis (GPA) over a 15-year period in a defined area of northern Italy. All patients with incident GPA diagnosed from January 1, 1995 to December 31, 2009 living in the Reggio Emilia area were identified by looking at computerized hospital discharge diagnoses, by contacting Reggio Emilia Hospital physicians and community-based specialists, and by checking the databases of the pathology and the laboratory departments and the Reggio Emilia district database for rare diseases. Patients were classified according to the European Medicines Agency (EMA) algorithm. Patients were followed up from the time of diagnosis until either their death or December 31, 2011. For each case, we identified 20 control subjects from the same geographic area matched for age and gender. A total of 18 patients (7 men and 11 women) with GPA were identified. The overall age- and sex-adjusted incidence rate (IR) was 2.4 per million (95% CI: 1.2-3.5). The mean annual IR increased from 1.7/million/year during 1995-1999 to 3.4 during 2005-2009. The highest IR occurred in females aged 70-79 years (13.5 per million; 95% CI: 5.0-30.0) and in males aged ≥ 80 years (14.9 per million; 95% CI: 2.5-49.4). The prevalence of GPA on December 31, 2009 was 34.3 per million (95% CI: 20.3-54.2). The point prevalence per million increased from 17.8 (95% CI: 7.7-35.1) in 1999 to 34.3 (95% CI: 20.3-54.2) in 2009. Survival among individuals with GPA was significantly reduced compared to that observed in the matched control population (p < 0.001). In the Italian population, GPA is very uncommon and GPA patients have reduced survival. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Results of endoscopic surgery and intralesional steroid therapy for airway compromise due to tracheobronchial Wegener's granulomatosis

    Directory of Open Access Journals (Sweden)

    S. A. R. Nouraei

    2008-04-01

    Full Text Available Background: Upper airway compromise due to tracheobronchial stenosis commonly occurs in patients with Wegener's Granulomatosis (WG. There is at present no consensus on the optimal management of this life-threatening condition. Objective: To assess the results of laryngo-tracheo-bronchoscopy, intralesional steroid therapy, laser surgery, and dilatation in managing obstructive tracheobronchial WG. Methods: Records of eighteen previously-untreated stridulous patients with obstructive tracheobronchial WG, treated between 2004 and 2006 were prospectively recorded on an airway database and retrospectively reviewed. Information about patient and lesion characteristics and treatment details were recorded. Treatment progress was illustrated using a timeline plot, and intervention-free intervals were calculated with actuarial analysis. Results: There were nine males and the average age at presentation was 40 (16 years [range 13–74]. There were thirteen patients with tracheal, and five patients with tracheal and bronchial lesions. The average tracheal lesion height was 8 (3 mm, located 23 (9 mm below the glottis. There were 1, 10 and 7 Myer-Cotton grade I, II and III lesions respectively. Mean intervention-free interval following minimally-invasive treatment was 26 (2.8 months. Following endobronchial therapy the median intervention-free interval was 22 months (p>0.8 vs. tracheal lesions. No patient required a tracheostomy or endoluminal stenting. Conclusions: Intralesional steroid therapy and conservative endoluminal surgery is an effective strategy for treating airway compromise due to active tracheal and bronchial WG, obviating the need for airway bypass or stenting. We recommend the combination of endotracheal dilatation, conservative laser surgery and steroid therapy as the standard of care for treating airway compromise due to obstructive tracheobronchial WG.

  8. Patients' perceptions of the effects of systemic lupus erythematosus on health, function, income, and interpersonal relationships : A comparison with Wegener's granulomatosis

    NARCIS (Netherlands)

    Boomsma, MM; Bijl, M; Stegeman, CA; Kallenberg, CGM; Hoffman, GS; Tervaert, JWC

    2002-01-01

    Objective. To describe the patients' perceptions of the effects of systemic lupus erythematosus (SLE) and Wegener's granulomatosis (WG) on health, function, income, and interpersonal relationships. Methods. 114 patients with SLE, and 79 patients with WG completed a self-administered questionnaire.

  9. Evaluation of capture ELISA for detection of antineutrophil cytoplasmic antibodies directed against proteinase 3 in Wegener's granulomatosis : first results from a multicentre study

    NARCIS (Netherlands)

    Csernok, E; Holle, J; Hellmich, B; Willem, J; Tervaert, C; Kallenberg, CGM; Limburg, PC; Niles, J; Pan, GL; Specks, U; Westman, K; Wieslander, J; Gross, WL

    Objective: To evaluate the performance characteristics of direct and capture ELISA for the detection of PR3-ANCA in Wegener's granulomatosis (WG) in international ANCA reference laboratories. Methods: Serum samples were derived from patients with histological and clinical diagnosis of WG (n = 60),

  10. High risk of pulmonary embolism and deep venous thrombosis but not of stroke in granulomatosis with polyangiitis (Wegener's)

    DEFF Research Database (Denmark)

    Faurschou, Mikkel; Obel, Niels; Baslund, Bo

    2014-01-01

    OBJECTIVE: To assess the incidence of stroke, pulmonary embolism (PE), and deep venous thrombosis (DVT) in granulomatosis with polyangiitis (Wegener's) (GPA). METHODS: Patients diagnosed with GPA at a Danish tertiary care center during 1993-2011 were identified (n = 180). Each patient was matched...... 20.2 [95% CI 5.1-81] for DVT). The incidence of stroke was not increased during this time interval (IRR 1.4 [95% CI 0.3-5.7]). From 2 years after GPA diagnosis, an increased incidence was found for DVT (IRR 4.5 [95% CI 1.7-11.8]) but not for PE (IRR 1.3 [95% CI 0.2-9.6]) or stroke (IRR 1.4 [95% CI 0...

  11. EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria

    DEFF Research Database (Denmark)

    Ozen, Seza; Pistorio, Angela; Iusan, Silvia M

    2010-01-01

    To validate the previously proposed classification criteria for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA)....

  12. Serial High-Resolution Computed Tomography Imaging in Patients with Wegener Granulomatosis: Differentiation Between Active Inflammatory and Chronic Fibrotic Lesions

    International Nuclear Information System (INIS)

    Lohrmann, C.; Uhl, M.; Schaefer, O.; Ghanem, N.; Kotter, E.; Langer, M.

    2005-01-01

    PURPOSE: To evaluate pulmonary pathologies in Wegener granulomatosis with sequential computed tomography (CT) in order to differentiate active inflammatory lesions from chronic fibrotic lesions. MATERIAL AND METHODS: Serial CT findings in 38 patients with Wegener granulomatosis were retrospectively analyzed (mean follow-up period, 21 months). The presence, extension, and distribution of the following findings were evaluated with CT: parenchymal nodules, masses, ground-glass attenuation, airspace consolidation, bronchial wall-thickening, bronchiectasis, linear areas of attenuation, pleural irregularities, pleural effusions, hilar and mediastinal lymphadenopathy. RESULTS: Observed in 92% of patients, nodules were the most common CT pathology. Areas of ground-glass attenuation, consolidation, masses of linear attenuation, and tracheal/bronchial wall-thickening were detected in 24%, 26%, 32%, 39%, and 68% of patients. At follow-up, the clearance of lesions was most consistent for areas of ground-glass attenuation (89%), masses (87%), and cavitated nodules (85%). In the follow-up scan, 58% of all nodules, 47% of pulmonary consolidations, and 66% of bronchial wall-thickening were completely resolved. Areas of bronchiectasis and septal/non-septal lines remained stable in 70% and 71% of patients. CONCLUSION: The majority of the lesions decreased or resolved completely with or without areas of linear attenuation. Ground-glass attenuation, cavitated nodules and masses appear to represent active inflammatory lesions. In most probability, areas of bronchiectasis and septal/non-septal lines more often represent chronic fibrotic changes rather than active inflammatory changes. In combination with clinical evaluation and bronchoscopy, CT assists in the assessment of disease activity

  13. Serial High-Resolution Computed Tomography Imaging in Patients with Wegener Granulomatosis: Differentiation Between Active Inflammatory and Chronic Fibrotic Lesions

    Energy Technology Data Exchange (ETDEWEB)

    Lohrmann, C.; Uhl, M.; Schaefer, O.; Ghanem, N.; Kotter, E.; Langer, M. [Univ. Hospital of Freiburg (Germany). Dept. of Radiology

    2005-08-01

    PURPOSE: To evaluate pulmonary pathologies in Wegener granulomatosis with sequential computed tomography (CT) in order to differentiate active inflammatory lesions from chronic fibrotic lesions. MATERIAL AND METHODS: Serial CT findings in 38 patients with Wegener granulomatosis were retrospectively analyzed (mean follow-up period, 21 months). The presence, extension, and distribution of the following findings were evaluated with CT: parenchymal nodules, masses, ground-glass attenuation, airspace consolidation, bronchial wall-thickening, bronchiectasis, linear areas of attenuation, pleural irregularities, pleural effusions, hilar and mediastinal lymphadenopathy. RESULTS: Observed in 92% of patients, nodules were the most common CT pathology. Areas of ground-glass attenuation, consolidation, masses of linear attenuation, and tracheal/bronchial wall-thickening were detected in 24%, 26%, 32%, 39%, and 68% of patients. At follow-up, the clearance of lesions was most consistent for areas of ground-glass attenuation (89%), masses (87%), and cavitated nodules (85%). In the follow-up scan, 58% of all nodules, 47% of pulmonary consolidations, and 66% of bronchial wall-thickening were completely resolved. Areas of bronchiectasis and septal/non-septal lines remained stable in 70% and 71% of patients. CONCLUSION: The majority of the lesions decreased or resolved completely with or without areas of linear attenuation. Ground-glass attenuation, cavitated nodules and masses appear to represent active inflammatory lesions. In most probability, areas of bronchiectasis and septal/non-septal lines more often represent chronic fibrotic changes rather than active inflammatory changes. In combination with clinical evaluation and bronchoscopy, CT assists in the assessment of disease activity.

  14. Paquimeningite hipertrófica e parotidite: manifestações raras da granulomatose de Wegener Hypertrophic pachymeningitis and parotiditis: unusual ocurrences of the Wegener's granulomatosis

    Directory of Open Access Journals (Sweden)

    Ana Paula Monteiro Gomides

    2004-08-01

    Full Text Available A granulomatose de Wegener é uma vasculite sistêmica dos vasos de médio e pequeno calibre. Classicamente, há formação de granulomas com necrose no trato respiratório e glomerulonefrite necrosante. Embora seu acometimento mais comum envolva o trato respiratório superior, pulmões e rins, uma vasta gama de manifestações em vários órgãos e tecidos é descrita. Relatamos o caso de um paciente que, paralelamente às manifestações típicas da doença, desenvolveu algumas alterações raras como a parotidite e a paquimeningite hipertrófica. Diante de quadros graves, atípicos e/ou refratários ao tratamento convencional, torna-se necessário o aprofundamento no estudo e uso de novas armas terapêuticas.The wegener's granulomatosis is a systemic angiitis of small and medium caliber vessels. Normally, it is characterized by the formation of granulomas with necrosis in the respiratory system and necrosing glomerulonephritis. even though it is more common in the upper respiratory system, in the lung and in the kidney, a great range of manifestation in other different organs and tissues can be described. we report the case of a patient who, in parallel with the typical symptoms of this disease, developed some rare alteration such as the parotiditis and the hypertrophic pachymeningitis. in face of serious situations, severe disease, atypical or non responsive to conventional treatments, it is necessary a more detailed study of the case and the use of new therapeutic drugs.

  15. Manifestação otológica localizada em paciente com granulomatose de Wegener Localized otologic manifestation in a patient with Wegener's granulomatosis

    Directory of Open Access Journals (Sweden)

    Márcia Regina Rosa Scalcon

    2008-08-01

    Full Text Available A granulomatose de Wegener (GW é uma vasculite granulomatosa multissistêmica rara, idiopática, que acomete vasos de pequeno e médio calibres, e que classicamente envolvem os tratos respiratórios superior, inferior e rins. Na forma limitada da doença, diversos sítios anatômicos podem ser afetados isoladamente. Foi descrito o caso de uma paciente jovem, que iniciou o acometimento da GW por dispnéia, estridor laríngeo e hipacusia. A investigação evidenciou o acometimento localizado na glote, e envolvimento da membrana timpânica comprovado por biópsia. A paciente obteve resposta com o tratamento instituído, mas permaneceu com seqüelas otológicas. Revisa-se neste artigo algumas das manifestações focais da GW, salientando especialmente as manifestações otológicas.Wegener's granulomatosis (WG is a rare, idiopathic granulomatous vasculitis, affecting small and medium-sized vessels, classically involving upper and lower respiratory tracts and kidneys. In the limited form of the disease, several other sites can be affected. We describe the case of a young woman who presented her disease with dyspnea, laryngeal stridor and hearing loss. Investigation revealed localized glottis involvement and a tympanum biopsy confirmed granulomatous vasculitis. The patient had a partial response with the treatment, with residual deafness. We performed a review concerning the focal manifestations of WG, focusing in the ear involvement.

  16. EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part I: Overall methodology and clinical characterisation

    DEFF Research Database (Denmark)

    Ruperto, Nicolino; Ozen, Seza; Pistorio, Angela

    2010-01-01

    To report methodology and overall clinical, laboratory and radiographic characteristics for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA) classification criteria.......To report methodology and overall clinical, laboratory and radiographic characteristics for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA) classification criteria....

  17. A Case of Simultaneous, Biopsy-Proven, Classic, ANCA-Positive Wegener's Granulomatosis and Anti-GBM Disease, but without Detectible Circulating Anti-GBM Antibodies

    OpenAIRE

    Gmurczyk, Aleksandra; Ahya, Shubhada N.; Goldschmidt, Robert; Kim, George; Ho, L. Tammy; Nash, Kevin

    2010-01-01

    Wegener's granulomatosis (WG) is a systemic, necrotizing, granulomatous vasculitis of unknown etiology. Approximately 75% of cases present as classic WG with both pulmonary and renal involvement, while the remaining 25% of patients present with a limited form with either predominantly upper or lower respiratory tract symptoms. Ninety percent of WG patients have circulating anti–neutrophil cytoplasmic antibodies (ANCA), and approximately 10% have both circulating ANCA antibodies and concomitan...

  18. Characteristics and Outcomes of Granulomatosis With Polyangiitis (Wegener) and Microscopic Polyangiitis Requiring Renal Replacement Therapy

    DEFF Research Database (Denmark)

    Hruskova, Zdenka; Stel, Vianda S; Jayne, David

    2015-01-01

    and matched nondiabetes patients. Patient and transplant survival after kidney transplantation, adjusted for time period and country, was better in AAV than in matched nondiabetes patients (HRs of 0.81 [95% CI, 0.67-0.99] and 0.82 [95% CI, 0.69-0.96], respectively). LIMITATIONS: No data for extrarenal...... for microscopic polyangiitis (prevailing in Southern Europe). Kidney transplantation was performed in 558 (22.2%) patients with vasculitis. The 10-year probability for survival on RRT after day 91 was 32.5% (95% CI, 29.9%-35.1%) in patients with vasculitis. Survival on RRT after day 91 did not differ between AAV...... manifestations, treatment, and relapses. CONCLUSIONS: Geographical differences in the incidence of RRT for kidney failure due to granulomatosis with polyangiitis and microscopic polyangiitis copied their distribution in the general population. Overall survival on RRT after day 91 for patients with AAV...

  19. Mastoidite e paralisia facial como manifestações iniciais de Granulomatose de Wegener Mastoiditis and facial paralysis as initial manifestations of Wegener's Granulomatosis

    Directory of Open Access Journals (Sweden)

    André Souza de Albuquerque Maranhão

    2012-04-01

    Full Text Available A Granulomatose de Wegener (GW é caracterizada por granulomas necrotizantes e vasculite. Sem tratamento a doença tem prognóstico pobre com índice de mortalidade de 90% em 2 anos. Diversos autores citam as manifestações otológicas no curso da GW, entretanto não é especificado em que momento da doença elas apareceram, isto é, se como manifestação inicial ou subsequente a outros achados. Objetivo: Descrever três casos confirmados de GW que apresentaram inicialmente mastoidite e evoluíram com paralisia facial periférica (PFP. Material e Método: Estudo de série de casos. Pacientes diagnosticados com GW que apresentaram inicialmente manifestações otológicas são descritos. Resultados: Os três casos descritos abriram o quadro com otalgia, otorreia e hipoacusia unilateral, associada a paralisia facial periférica ipsilateral. Tiveram resposta inadequada aos tratamentos instituídos o que motivou uma investigação de outras doenças associadas. Nessas circunstâncias, detectaram-se títulos positivos de ANCA-C em todos pacientes, confirmando-se o diagnóstico de GW, após período variável de investigação. Institui-se o tratamento para GW observando-se melhora do quadro clínico, regressão da PFP e melhora parcial dos limiares auditivos. Conclusão: Complicações de otites médias agudas (mastoidite e PFP refratárias as terapêuticas habituais impõem a investigação de doenças associadas e a GW deverá ser pesquisada para que se possa fazer o diagnóstico o mais precocemente possível, alterando desta forma o prognóstico destes pacientes.Wegener's Granulomatosis (WG is characterized by necrotizing granulomas and vasculitis. If left untreated, the prognosis is poor - a 90% mortality rate within 2 years. Several authors have described the otologic manifestations of WG; these authors, however, have not mentioned the stage of the disease in which these findings present - whether as initial manifestations or subsequent to

  20. Active disease and residual damage in treated Wegener's granulomatosis: an observational study using pulmonary high-resolution computed tomography

    International Nuclear Information System (INIS)

    Komocsi, Andras; Reuter, Michael; Heller, Martin; Murakoezi, Henriette; Gross, Wolfgang L.; Schnabel, Armin

    2003-01-01

    The purpose of this study was to determine to what extent high-resolution computed tomography (HRCT) of the lungs can distinguish active inflammatory disease from inactive cicatricial disease in patients treated for Wegener's granulomatosis (WG). Twenty-eight WG patients with active pulmonary disease underwent a first HRCT examination immediately before standard immunosuppressive treatment and a second examination after clinical remission had been achieved. Lesions remaining after treatment were categorized as residual damage and were compared with findings during active disease to see by what features active and cicatricial disease can be distinguished. During active disease 17 patients had nodules/masses, 12 had ground-glass opacities, 6 had septal lines and 6 had non-septal lines. After treatment, ground-glass opacities had resolved completely. Nodules/masses had resolved in 8 patients and had diminished in 7 patients. Residual nodules were distinguished from nodules/masses in active disease by lack of cavitation and a diameter of mostly <15 mm. In one-third of patients lines resolved, but in 8 instances new lines evolved during immunosuppression. During a follow-up period of a median 26.5 months (range 20.0-33.8), patients with residual nodules or lines had no more relapses than patients with completely cleared lungs. Treated pulmonary WG leaves substantial residual damage. High-resolution CT does assist in the distinction between active and inactive lesions. Ground-glass opacities, cavitating nodules/masses and masses measuring more than 3 cm represent active disease ordinarily. Non-cavitary small nodules and septal or non-septal lines can be either active or cicatricial lesions. The nature of these lesions needs to be clarified by longitudinal observation. (orig.)

  1. Granulomatosis with Polyangiitis (Wegener's)

    Science.gov (United States)

    ... American College of Rheumatology Committee on Communications and Marketing. This information is provided for general education only. Individuals should consult a qualified health care provider for professional medical advice, diagnosis and treatment of a medical ...

  2. Estenose subglótica como manifestação clínica da granulomatose de Wegener em adolescentes: relato de caso e revisão de literatura Subglottic stenosis as a clinical manifestation of Wegener's granulomatosis in adolescents: report of a case and review of literature

    Directory of Open Access Journals (Sweden)

    Márcia C. Machado

    2003-10-01

    Full Text Available A Granulomatose de Wegener é uma patologia caracterizada por vasculite sistêmica e inflamação granulomatosa necrotizante que compromete o trato respiratório alto, pulmões e rins, cujas manifestações iniciais, na maioria das vezes, ocorre em maiores de 20 anos de idade. As queixas clínicas otorrinolaringológicas estão, com freqüência, presentes nas fases iniciais da doença, sendo rinite, sinusopatia de repetição e epistaxe as mais comuns. A estenose subglógica parece estar correlacionada com a Granulomatose de Wegener em adolescentes. Relatamos o caso de uma paciente portadora de Granulomatose de Wegener cujo início dos sintomas foi na infância, tendo evoluído com estenose laríngea durante o curso da doença.Wegener's Granulomatosis is a well-characterized systemic vasculitis and necrotising granulomatous inflammation of the upper, lower respiratory tracts and the kidneys. The initial manifestations of the disease usually occur in patients over than twenty years old. The otolaryngologic symptoms like rhinorrhea, recurrent sinusitis and epistaxis are commonly present in early course of the disease. It seems that subglottic stenosis is correlated to Wegener's granumatosis in adolescents. We describe a case of a patient that developed subglottic stenosis associated with Wegener's granulomatosis in childhood during the course of the disease.

  3. Increased frequency of CCR4+ and CCR6+ memory T-cells including CCR7+CD45RAmed very early memory cells in granulomatosis with polyangiitis (Wegener's)

    OpenAIRE

    Fagin, Ursula; Pitann, Silke; Gross, Wolfgang L; Lamprecht, Peter

    2012-01-01

    Introduction Chemokine receptors play an important role in mediating the recruitment of T cells to inflammatory sites. Previously, small proportions of circulating Th1-type CCR5+ and Th2-type CCR3+ cells have been shown in granulomatosis with polyangiitis (GPA). Wondering to what extent CCR4 and CCR6 expression could also be implicated in T cell recruitment to inflamed sites in GPA, we investigated the expression of CCR4 and CCR6 on T cells and its association with T cell diversity and polari...

  4. Synchronous advanced pulmonary tuberculosis and acute virus myocarditis mimicked wegener granulomatosis in a 26-year-old man: A case report

    Directory of Open Access Journals (Sweden)

    Pešut Dragica P.

    2016-01-01

    Full Text Available Introduction. Tuberculosis patients are rarely asymptomatic. Acute virus myocarditis presents with a wide range of symptoms, from mild dyspnea or chest pain to cardiogenic shock and death. Case Outline. A 26-year-old Caucasian man non-smoker presented with one-week history of lower extremities’ swelling. The patient’s medical history also revealed a two-day episode of subfebrile temperature with scanty hemoptysis three weeks prior to admission. The episode had not provoked him to seek medical care. Physical examination revealed generalized oedema, and laboratory analysis showed signs of acute renal insufficiency. Enlarged heart and hilar shadows, bilateral massive cavitary pulmonary opacities and pleural effusion were found at chest radiography. Sputum smears were Mycobacteria negative on direct microscopy. Electrocardiogram changes and echocardiography were suggestive of acute myocarditis with dilated cardiomyopathy. IgM titer to adenovirus was positive. Under diuretics, angiotensin-converting-enzyme inhibitor, beta-blocker, antibiotics and bed rest, fast heart compensation and renal function repair were achieved. Radiographic pulmonary changes promptly regressed except for a cavity in the right upper lobe. Bronchial aspirate from the affected lobe was Mycobacteria positive on direct microscopy and culture positive for Mycobacterium tuberculosis. Standard anti-tuberculosis drug regimen led to recovery. Conclusion. In the unusual common existence of two diseases whose presentation initially mimicked Wegener’s granulomatosis, acute dilated cardiomyopathy contributed to pulmonary tuberculosis detection. To prevent diagnostic delay in tuberculosis, further efforts in population education are necessary together with continual medical education. [Projekat Ministarstva nauke Republike Srbije, br. 175095

  5. Prevalência das manifestações clínicas iniciais da granulomatose de Wegener no Brasil: relato de seis casos e revisão da literatura Wegener's granulomatosis: prevalence of the initial clinical manifestations - report of six cases and review of the literature

    Directory of Open Access Journals (Sweden)

    Carlos Ewerton Maia Rodrigues

    2010-04-01

    Full Text Available OBJETIVOS: Descrever as manifestações clínicas iniciais da Granulomatose de Wegener (GW diagnosticada no Brasil. PACIENTES E MÉTODOS: Análise retrospectiva de seis prontuários do Serviço de Reumatologia do Hospital Geral de Fortaleza (HGF, assim como a realização de um levantamento bibliográfico dos casos de GW descritos no Brasil obtidos dos bancos de dados LILACS, SciELO e MEDLINE. RESULTADOS: O estudo identificou 49 pacientes; 15 (31% do sexo masculino e 34 (69% do sexo feminino. A forma sistêmica ocorreu em 35 pacientes (73%: 28 adultos, cinco crianças e dois adolescentes. A doença limitada ocorreu em 13 adultos e uma criança. A média da idade adulta no início da doença foi de 42,2 anos (18 a 65 anos. O quadro clínico agudo, com sintomas há menos de três meses do diagnóstico, ocorreu em 41% (20/49 da casuística e a forma insidiosa, em 59% (29/49 dos pacientes. A prevalência das manifestações clínicas iniciais nos adultos com doença sistêmica (n = 28 foi 64% (18/28 das vias aéreas superiores (VAS, 36% (10/28 pulmonares, 18% (5/28 renais, 25% (7/28 oculares, 11% (3/28 cutâneas, 25% (7/28 musculoesqueléticas e 7% (2/28 neurológicas. Na forma limitada do adulto (n = 13, os sintomas prevalentes foram 84% (11/13 VAS, 23% (3/13 oculares e 15% (2/13 pulmonares. CONCLUSÃO: No Brasil, a prevalência das manifestações clínicas iniciais da GW foi semelhante aos resultados da literatura. A falta de especificidade dos sintomas pode retardar o diagnóstico na forma insidiosa da doença e aumentar a morbimortalidade das formas agudas.OBJECTIVES: To describe the initial clinical manifestations of Wegener's Granulomatosis (WG in Brazil. PATIENTS AND METHODS: Retrospective analysis of six medical records of WG patients followed-up at the Rheumatology Department of Hospital Geral of Fortaleza (HGF, as well as a bibliographic survey of cases of WG in Brazil on LILACS, SciELO, and MEDLINE databases. RESULTS: The study

  6. MACULA RETINAL VASCULITIS AND CHOROIDITIS ASSOCIATED WITH GRANULOMATOSIS WITH POLYANGIITIS.

    Science.gov (United States)

    Lim, Lik Thai; Vasudevan, Vinaya; Shelton, Julie; Vitale, Albert T; Moorthy, Ramana

    2017-01-01

    To report a case series of two cases of granulomatosis with polyangiitis, previously known as Wegener granulomatosis, which developed macular necrosis, not previously associated with granulomatosis with polyangiitis, healed with fibrosis, despite aggressive immune-modulating therapy and good control of systemic disease. Case series of two cases with observation of treatment progress. The results reported the progress of response to treatment in the two cases, which resulted in the final outcome of fibrosis in the macula region, despite being on aggressive immune-modulating therapy and good systemic control. Granulomatosis with polyangiitis can be associated with macular necrosis leading to fibrosis, unresponsive to immune-modulating therapy.

  7. Adolescente femenino con granulomatosis de Wegener fulminante

    Directory of Open Access Journals (Sweden)

    S C Scheffler-Mendoza

    2017-01-01

    Full Text Available Adolescente femenino de 13 años de edad, originaria de Guerrero, grupo étnico mixteco, padres analfabetos y con poco entendimiento del español. Sin otros antecedentes de importancia para el padecimiento. Inició un mes previo con la aparición de una pápula hipercrómica en párpado superior derecho que en los 10 días previos al ingreso aumentó de volumen generando proptosis. Al interrogatorio se negó dolor, lagrimeo, fiebre, o pérdida de peso. Ingresó con fiebre (39.0°C, palidez generalizada, proptosis derecha con exposición de córnea y conjuntiva, eritema periorbitario, movimientos oculares y agudeza visual disminuidos (i.e. contaba dedos a 1 m, pupila con tendencia a midriasis, hiperreactividad a la luz, y fondo de ojo con papila hiperémica edematosa y tortuosidad peripapilar. El resto de exploración no mostró datos relevantes. Se hospitalizó para iniciar tratamiento antimicrobiano parenteral de amplio espectro (i.e. ceftriaxona y vancomicina y abordar proptosis unilateral.

  8. Diagnostic Consideration for Sinonasal Wegener’s Granulomatosis Clinically Mistaken for Carcinoma

    Directory of Open Access Journals (Sweden)

    Cristina La Rosa

    2013-01-01

    Full Text Available We report a case of Wegener’s granulomatosis clinically mistaken for carcinoma in a 21-year-old girl presenting with an ulcerated mass of the nasopharynx associated with enlarged laterocervical nodes. The lesion was clinically suspected as malignant on the basis of clinical and radiological findings (namely, computed tomography scan and positron emission tomography. However, multiple biopsies were not conclusive for malignancy showing histological change suggestive of Wegener’s granulomatosis. A serum determination of cANCA supported the diagnosis of Wegener’s granulomatosis. Clinical findings and image studies suggested an erroneous diagnosis of malignancy whereas a definitive diagnosis of Wegener’s granulomatosis was achieved only after repeated biopsies thus leading to a correct therapeutic approach. The Wegener granulomatosis must be added to the list of the differential diagnoses of the masses of the nasopharynx associated with or without enlarged laterocervical nodes.

  9. Cancer preceding Wegener's granulomatosis: a case-control study

    DEFF Research Database (Denmark)

    Faurschou, Mikkel; Mellemkjaer, Lene; Sorensen, Inge J

    2009-01-01

    OBJECTIVE: To investigate whether patients with WG have an increased risk of malignancies prior to and/or around the time of the vasculitis diagnosis, as suggested by previous studies. METHODS: A total of 293 WG patients were included in the study. Ten gender- and age-matched controls were selected.......4; 95% CI 1.1, 38) based on two patients, who developed testis cancer >10 years before WG. The overall prevalence of malignancies diagnosed time...... interval (OR 4.0; 95% CI 1.4, 12). CONCLUSIONS: We did not find clear evidence of an increased prevalence of preceding cancer in our WG cohort, indicating that shared risk factors are of minor importance for the excess of malignancies that occur in WG patients after the vasculitis diagnosis. Furthermore...

  10. Treatment of orbital inflammation with rituximab in Wegener's granulomatosis

    DEFF Research Database (Denmark)

    Baslund, Bo; Wiencke, Anne Katrine; Rasmussen, Niels

    2012-01-01

    by CT-scan before treatment (3 had bilateral and 7 unilateral orbital involvement). Orbital symptoms at study baseline included pain, pressure sensation behind the eyes, epiphora, diplopia, and affection of the visual acuity. Nine out of ten patients experienced subjective improvement. Four patients...

  11. An overlap of granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis

    Directory of Open Access Journals (Sweden)

    Sujit Surendran

    2017-01-01

    Full Text Available We present a case report of overlap of granulomatosis with polyangiitis (GPA; formerly known as Wegener’s granulomatosis and eosinophilic granulomatosis with polyangiitis (EGPA; formerly known as Churg-Strauss syndrome. We report a 45-year-old female who presented with rapidly progressive renal failure associated with fever, polyarthralgia, and respiratory symptoms with cytoplasmic antineutrophilic cytoplasmic antibody (ANCA and proteinase (PR-3 antigen positivity. Computerized tomography scan of the chest showed diffuse alveolar hemorrhage with renal biopsy revealing pauci-immune necrotizing crescentic glomerulonephritis with intense eosinophilic infiltration suggestive of eosinophilic GPA (EGPA. Our patient had ANCA-associated vasculitis (AAV with features suggestive of both GPA and EGPA. She was treated with methylprednisolone and cyclophosphamide and attained remission after 2 weeks of therapy. This is a rare report of a patient with AAV having features of both EGPA and GPA.

  12. Pituitary granulomatosis with polyangiitis

    OpenAIRE

    Slabu, Hannah; Arnason, Terra

    2013-01-01

    Granulomatosis with polyangiitis (GPA) is a small vessel vasculitis that can affect several organs, most commonly the respiratory tract and kidneys. Pituitary involvement is exceptionally rare. Most case reports of GPA of the pituitary gland have been described in middle-aged women who have concomitant ears, nose and throat involvement. The most frequent manifestation is diabetes insipidus due to a preponderance of posterior pituitary infiltration. The majority of cases sustain permanent dama...

  13. Culturele Veranderingen: het wegen waard?

    NARCIS (Netherlands)

    Mérove Gijsberts

    1993-01-01

    Verslag van een verkennend onderzoek naar de effecten van weging op de bestanden 'Culturele Verkenningen'. In kaart wordt gebracht in hoeverre er sprake is van selectieve non-respons in de databestanden. Het verschijnsel non-respons wordt nader belicht, evenals het begrip 'wegen',

  14. Granulomatosis with polyangiitis presenting as facial nerve palsy in a teenager.

    Science.gov (United States)

    Wang, James C; Leader, Brittany A; Crane, Ryan A; Koch, Bernadette L; Smith, Matthew M; Ishman, Stacey L

    2018-04-01

    Granulomatosis with polyangiitis (GPA, previously known as Wegener's granulomatosis) is an autoimmune systemic small-vessel vasculitis, associated with the presence of anti-neurophil cytoplasmic antibodies with a cytoplasmic staining pattern (c-ANCA). It is characterized by necrotizing granulomas, usually affecting the airways and kidneys. GPA should be considered when patients do not improve despite adequate treatment of otologic symptoms, when patients have unspecific symptoms suggesting systemic disease (e.g. fever, malaise), or when other organs are involved (kidney, lungs, etc.). We present an interesting case of a 14-year-old female with eight-weeks of bilateral otalgia, unilateral facial nerve palsy, decreased appetite, and fatigue refractory to steroid, anti-viral, and antibiotic treatment ultimately diagnosed with GPA. Copyright © 2018. Published by Elsevier B.V.

  15. Granulomatose de Wegener – Envolvimento otológico, nasal, laringotraqueal e pulmonar

    Directory of Open Access Journals (Sweden)

    Sandra Figueiredo

    2009-09-01

    Full Text Available Resumo: A granulomatose de Wegener é uma vasculite sistémica rara e idiopática caracterizada pelo atingimento dos pequenos vasos. A doença atinge, preferencial-mente, as vias aérea superior e inferior e os rins, levando à formação de granulomas e necrose destes órgãos. As manifestações clínicas e o envolvimento orgânico variam largamente. O diagnóstico e tratamento precoce podem levar à recuperação total. No entanto, o atraso no diagnóstico pode ser fatal. Os autores apresentam o caso de uma doente de 33 anos com uma forma de apresentação grave e rara da doença, mas com uma evolução favorável após diagnóstico e tratamento adequado.Rev Port Pneumol 2009; XV (5: 929-935 Abstract: Wegener granulomatosis is a rare systemic idiopathic disease characterized by involvement of small vessels – medium and small arteries, venules, arterioles and ocasionally large arteries. This disease has predilection for the upper and lower respiratory tract and the kidney, with granulomatous inflamation and necrosis. Clinical manifestations and organ involvement of the disease vary widely. Early diagnosis and treatment may lead to a full recovery. Without treatment, Wegener’s granulomatosis can be fatal. The authors present a case of a 33 year-old female, with severe disease, but with good outcome, after adequate diagnosis and treatment.Rev Port Pneumol 2009; XV (5: 929-935 Palavras-chave: Granulomatose de Wegener, forma limitada grave, Key-words: Wegener´s granulomatosis, severe limited form

  16. Pulmonary talc granulomatosis in a cocaine sniffer.

    Science.gov (United States)

    Oubeid, M; Bickel, J T; Ingram, E A; Scott, G C

    1990-07-01

    The development of pulmonary granulomatosis following intravenous injection of medications intended for oral use has been well described previously. Talc is the most commonly implicated agent. We present a case of talc granulomatosis which developed in a patient following cocaine sniffing and suggest that this may be the cause of development of granulomata in drug addicts who deny any history of intravenous drug abuse.

  17. Pulmonary lymphomatoid granulomatosis in a 4-year-old girl

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Subin; Kang, Mi-Jin; Lee, Jihae [Inje University Sanggye Paik Hospital, Department of Radiology, 1342, Dongilro, Nowon-gu, Seoul (Korea, Republic of); Kim, Hyun-Jung [Inje University Sanggye Paik Hospital, Department of Pathology, 1342, Dongilro, Nowon-gu, Seoul (Korea, Republic of); Kim, Hyo-Bin [Inje University Sanggye Paik Hospital, Department of Pediatrics, 1342, Dongilro, Nowon-gu, Seoul (Korea, Republic of)

    2015-07-15

    Lymphomatoid granulomatosis is a rare lymphoproliferative disease associated with the Epstein-Barr virus that commonly affects the lung. There is limited literature on cases of pediatric lymphomatoid granulomatosis. Half of all cases of lymphomatoid granulomatosis develop during the treatment of leukemia. Herein, we describe a case of lymphomatoid granulomatosis in a previously healthy child without leukemia. (orig.)

  18. Wegener’s granulomatosis and pyoderma gangrenosum – rare causes of facial ulcerations

    Directory of Open Access Journals (Sweden)

    Karolina Kędzierska

    2016-03-01

    Full Text Available Background: Pyoderma gangrenosum (PG is caused by immune system dysfunction, and particularly improper functioning of neutrophils. At least half of all PG patients also suffer from autoimmunological diseases, one of which is Wegener granulomatosis (WG. The purpose of this article was to compare cases of patients with WG and PG in terms of their clinical course, histopathology, and applied treatment. In both, histopathological features are not fully distinct. Data from microbiological and immunological evaluation and clinical presentation are required to establish the diagnosis. We also present the case of a patient with WG and deep facial skin lesions not responding to standard treatment. Methods: Systematic review of the literature in PubMed using the search terms “Wegener granulomatosis AND Pyoderma gangrenosum” and case report. Results: The finding of 22 reports in the literature (PubMed suggests that it is a rare phenomenon. This study revealed a similar rate of comorbidity of WG and PG in both genders and an increased incidence of both diseases after the age of 50. Among skin lesions there was a dominance of ulceration, most often deep and painful, covering a large area with the presence of advanced necrosis and destruction of the surrounding tissue. The most common location proved to be the cervical-cephalic area. The most popular treatment included steroids with cyclophosphamide. Discussion: The rarity of the coexistence of these two diseases results in a lack of effective therapy. In such cases sulfone derivatives are still effective and provide an alternative to standard immunosuppression methods. Hyperbaric therapy and plasmapheresis can also play an important complementary role.

  19. Eosinophilic Granulomatosis with Polyangiitis, formerly Churg-Strauss Syndrome (EGPA)

    Science.gov (United States)

    ... Strauss Syndrome (EGPA) Eosinophilic Granulomatosis with Polyangiitis, formerly Churg-Strauss Syndrome (EGPA) First Description Who gets EGPA (the “ ... granulomatosis with polyangiitis (EGP), formerly known as the Churg-Strauss Syndrome , is a systemic vasculitis. This disease was ...

  20. [Granulomatosis with polyangiitis manifested as diabetes insipidus].

    Science.gov (United States)

    Pátek, Ondřej; Horáčková, Miroslava; Vítová, Lenka; Horváth, Rudolf; Háček, Jaromír; Schück, Otto

    The case report shows a surprising presentation of pulmonary granulomatosis with polyangiitis (GPA) through symptoms of diabetes insipidus (DI) with granulomatous infiltration of the pituitary gland. The pituitary hormonal dysfunction as a result of granulomatosis of the pituitary gland is rare. Several studies have demonstrated that the incidence of the pituitary dysfunction reaches approx. 1 % of the patients with GPA. However it is mostly presented in patients with the disease already diagnosed. The patient described by us had no clinical expressions of GPA in the respiratory tract. He presented with polyuria and polydipsia. It was not until a more detailed examination of these symptoms was performed that a focal lung disease was detected and diagnosed as GPA. diabetes insipidus - granulomatosis with polyangiitis - granulomatous infiltration of the pituitary gland - pituitary hormonal dysfunction.

  1. Characteristics of patients with orofacial granulomatosis.

    LENUS (Irish Health Repository)

    McCartan, B E

    2011-10-01

    Orofacial granulomatosis has mostly been described in reports of very small numbers of cases. Few large case groups have been described. The aim of this study was to describe the demographics, symptoms, clinical features and laboratory findings in a large cohort of cases.

  2. Granulomatous Lymphoproliferative Disorders: Granulomatous Slack Skin and Lymphomatoid Granulomatosis.

    Science.gov (United States)

    Gangar, Pamela; Venkatarajan, Sangeetha

    2015-07-01

    Granulomatous cutaneous T-cell lymphomas (CTCL) and lymphomatoid granulomatosis are considered granulomatous lymphoproliferative disorders. The most common types of granulomatous CTCL are granulomatous mycosis fungoides and granulomatous slack skin. Lymphomatoid granulomatosis is a rare Epstein-Barr virus driven lymphoproliferative disorder. This article reviews the etiopathogenesis, clinical presentation, systemic associations, and management of both granulomatous slack skin syndrome and lymphomatoid granulomatosis. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. Computerized tomography

    International Nuclear Information System (INIS)

    Rubashov, I.B.

    1985-01-01

    Operating principle is described for the devices of computerized tomography used in medicine for diagnosis of brain diseases. Computerized tomography is considered as a part of computerized diagnosis, as a part of information science. It is shown that computerized tomography is a real existed field of investigations in medicine and industrial production

  4. Comparing Presenting Clinical Features in 48 Children With Microscopic Polyangiitis to 183 Children Who Have Granulomatosis With Polyangiitis (Wegener's)

    DEFF Research Database (Denmark)

    Cabral, David A; Canter, Debra L; Muscal, Eyal

    2016-01-01

    with GPA, whose diagnoses had been classified according to both adult- and pediatric-specific criteria. Descriptive statistics were used for comparisons. RESULTS: In total, 231 of 440 patients (64% female) fulfilled the classification criteria for either MPA (n = 48) or GPA (n = 183). The median time...

  5. Contrasting association of a non-synonymous leptin receptor gene polymorphism with Wegener's granulomatosis and Churg-Strauss syndrome.

    Science.gov (United States)

    Wieczorek, Stefan; Holle, Julia U; Bremer, Jan P; Wibisono, David; Moosig, Frank; Fricke, Harald; Assmann, Gunter; Harper, Lorraine; Arning, Larissa; Gross, Wolfgang L; Epplen, Joerg T

    2010-05-01

    There is evidence that the leptin/ghrelin system is involved in T-cell regulation and plays a role in (auto)immune disorders such as SLE, RA and ANCA-associated vasculitides (AAVs). Here, we evaluate the genetic background of this system in WG. We screened variations in the genes encoding leptin, ghrelin and their receptors, the leptin receptor (LEPR) and the growth hormone secretagogue receptor (GHSR). Three single nucleotide polymorphisms (SNPs) in each gene region were analysed in 460 German WG cases and 878 ethnically matched healthy controls. A three-SNP haplotype of GHSR was significantly associated with WG [P = 0.0067; corrected P-value (P(c)) = 0.026; odds ratio (OR) = 1.30; 95% CI 1.08, 1.57], as was one non-synonymous SNP in LEPR (Lys656Asn, P = 0.0034; P(c) = 0.013; OR = 0.72; 95% CI 0.58, 0.90). These four SNPs were re-analysed in independent cohorts of 226 German WG cases and 519 controls. While the GHSR association was not confirmed, allele frequencies of the LEPR SNP were virtually identical to those from the initial cohorts. Analysis of this SNP in the combined WG and control panels revealed a significant association of the LEPR 656Lys allele with WG (P = 0.00032; P(c) = 0.0013; OR = 0.72; 95% CI 0.60, 0.86). Remarkably, the Lys656Asn SNP showed contrasting allele distribution in two cohorts of 108 and 88 German cases diagnosed with Churg-Strauss syndrome (CSS, combined P = 0.0067; OR = 1.41; 95% CI 1.10, 1.81), whereas identical allele frequencies were revealed when comparing British WG and microscopic polyangiitis cases. While GHSR has to be further evaluated, these data provide profound evidence for an association of the LEPR Lys656Asn SNP with AAV, resulting in opposing effects in WG and CSS.

  6. Clinical, imaging and histopathological features of isolated CNS lymphomatoid granulomatosis

    International Nuclear Information System (INIS)

    Patil, Anil Kumar; Alexander, Mathew; Nair, Bijesh; Chacko, Geeta; Mani, Sunithi; Sudhakar, Sniya

    2015-01-01

    Lymphomatoid granulomatosis is a rare systemic angiocentric/angiodestructive, B cell lymphoproliferative disorder. Central nervous system involvement occurs as part of systemic disease. Isolated central nervous system disease is rare with only few case reports. A 53-year-old male presented with progressive cognitive decline, extrapyramidal features, and altered sensorium with seizures over the last 4 years. His magnetic resonance imaging (MRI) of brain showed multiple small enhancing nodules in subependymal/ependymal regions and along the vessels. Brain biopsy showed atypical lymphohistiocytic infiltrate suggestive of lymphomatoid granulomatosis. There was no evidence of systemic disease; thus, isolated central nervous system lymphomatoid granulomatosis was diagnosed

  7. Pediatric Vasculitis Initiative

    Science.gov (United States)

    2017-05-01

    Wegeners Granulomatosis (Granulomatosis With Polyangiitis); Microscopic Polyangiitis; Churg Strauss Syndrome (Eosinophilic Granulomatosis With Polyangiitis); Polyarteritis Nodosa; Takayasu Arteritis; Primary CNS Vasculitis; Unclassified Vasculitis

  8. Eosinophilic granulomatosis with polyangiitis: an overview

    Directory of Open Access Journals (Sweden)

    Andrea eGioffredi

    2014-11-01

    Full Text Available Eosinophilic granulomatosis with polyangiitis (EGPA is a multisystemic disorder, belonging to the small vessel ANCA-associated vasculitis, defined as a eosinophil-rich and necrotizing granulomatous inflammation often involving the respiratory tract, and necrotizing vasculitis predominantly affecting small to medium-sized vessels, associated with asthma and eosinophilia. EGPA pathogenesis is not well known: HLA-DRB1*04 and *07, HLA-DRB4 and IL10.2 haplotype of the IL-10 promoter gene are the most studied genetic determinants. Among the acquired pathogenetic factors, the exposure to different allergens, infections, vaccinations, drugs and silica exposure have been involved.Eosinophils are the most characteristic cells in EGPA and different studies have demonstrated their role as effector and immunoregulatory cells.EGPA is considered a disease with a prevalent activation of the Th2 cellular-mediated inflammatory response but also humoral immunity plays an important role. A link between B and T inflammatory responses may explain different disease features. EGPA typically develops into three sequential phases: the allergic phase, distinguished by the occurrence of asthma, allergic rhinitis and sinusitis, the eosinophilic phase, in which the main pathological finding is the eosinophilic organ infiltrations (e.g. lungs, heart and gastrointestinal system and the vasculitic phase, characterized by purpura, peripheral neuropathy and constitutional symptoms.ANCA (especially pANCA anti-MPO are present in 40-60% of the patients. An elevation of IgG4 is frequently found. Corticosteroids and cyclophosphamide are classically used for remission induction, while azathioprine and methotrexate are the therapeutic options for remission maintenance. B-cell depletion with rituximab has shown promising results for remission induction.

  9. Respiratory manifestations of eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

    NARCIS (Netherlands)

    Cottin, Vincent; Bel, Elisabeth; Bottero, Paolo; Dalhoff, Klaus; Humbert, Marc; Lazor, Romain; Sinico, Renato A.; Sivasothy, Pasupathy; Wechsler, Michael E.; Groh, Matthieu; Marchand-Adam, Sylvain; Khouatra, Chahéra; Wallaert, Benoit; Taillé, Camille; Delaval, Philippe; Cadranel, Jacques; Bonniaud, Philippe; Prévot, Grégoire; Hirschi, Sandrine; Gondouin, Anne; Dunogué, Bertrand; Chatté, Gérard; Briault, Amandine; Jayne, David; Guillevin, Loïc; Cordier, Jean-François

    2016-01-01

    The respiratory manifestations of eosinophilic granulomatosis with polyangiitis (EGPA) have not been studied in detail.In this retrospective multicentre study, EGPA was defined by asthma, eosinophilia and at least one new onset extra-bronchopulmonary organ manifestation of disease.The study

  10. Orbital lymphomatoid granulomatosis - a rare cause of proptosis

    Energy Technology Data Exchange (ETDEWEB)

    Du Toit, Jacqueline; Kilborn, Tracy [Department of Radiology, Red Cross Children' s Hospital, Rondebosch (South Africa); Eyssen, Ann van [Department of Oncology, Red Cross Children' s Hospital, Rondebosch (South Africa); Pillay, Komala [Department of Pathology, Red Cross Children' s Hospital, Rondebosch (South Africa)

    2015-07-15

    A 1-year-old girl with unilateral proptosis was found to have primary orbital lymphomatoid granulomatosis - a condition rarely occurring in children. This multisystem angiocentric, angiodestructive, lymphoproliferative disease typically involves the lungs, with ocular involvement being extremely uncommon. Our case serves to illustrate the imaging findings of this unusual condition and highlight a rare cause of proptosis. (orig.)

  11. Lymphomatoid and Mediastinal Granulomatosis in 2-Year-Old Child

    Directory of Open Access Journals (Sweden)

    S.V. Vesely

    2014-02-01

    24.07.13 the operation was performed: right thoracotomy, removal of the tumor of the upper lobe of right lung. Immunohistochemical examination results were received: lymphomatoid granulomatosis, grade II. The postoperative period was uneventful. Sutures are removed, the wound healed by primary intention. 10.08.13 the child was discharged home. Further treatment in Minsk (Belarus is planned.

  12. "Wegener’s granulomatosis in a patient with Rheumatoid arthritis "

    Directory of Open Access Journals (Sweden)

    "Ahmadi Nejad Z

    2001-06-01

    Full Text Available Wegener’s Granulomatosis is a necrotizing granulomatous vasculitis involving small and medium sized vessels. The syndrome is classically defined as having involvement of kidney, lungs and upper respiratory tract (i.e. sinuses. Wegener’s Granulomatosis may be present in other autoimmune or inflammatory diseases, particulary systemic lupus erythematosis (SLE, but most frequently has been associated with polyarteritis and glumerulonephritis.We present a case of wegener’s Granulomatosis (WG in a middle age lady with Rheumatiod Arthritis (RA; and discuss the implications of these two conditions co-existing in one patient. As for as we are aware, through medline and interent research, this is probably the fourth case with such as association of WG and RA and the fist one in Iran.Presentation of new uncontrollable sing and symptoms, in a previously well controlled RA patient, might suggest a new overlapping syndrome like Wegener’s Granulomatosis besides to flare up of previous disease as differential diagnosis

  13. Patch testing for food-associated allergies in orofacial granulomatosis.

    LENUS (Irish Health Repository)

    Fitzpatrick, Laura

    2011-01-01

    Food-associated allergies, especially to benzoates and cinnamon-related compounds, have been associated with orofacial granulomatosis and both standard and urticarial patch testing have been used to detect such allergies. Elimination diets have also been shown to be effective in some patients.

  14. A Case of Wegener’s Granulomatosis Presenting with Unilateral Facial Nerve Palsy

    Directory of Open Access Journals (Sweden)

    Roy Ujjawal

    2016-01-01

    Full Text Available Wegener’s granulomatosis or granulomatosis with polyangiitis is a necrotizing vasculitis affecting both arterioles and venules. The disease is characterized by the classical triad involving acute inflammation of the upper and lower respiratory tracts with renal involvement. However, the disease pathology can affect any organ system. This case presents Wegener’s granulomatosis presenting with facial nerve palsy as the first manifestation of the disease, which is rarely reported in medical literature.

  15. A Rare Presentation of a Rare Disease: Pulmonary Lymphomatoid Granulomatosis

    Directory of Open Access Journals (Sweden)

    Ghulam Rehman Mohyuddin

    2012-01-01

    Full Text Available A 70-year-old female presented with a 4-week history of dry cough and wheezing. Chest radiograph showed a 10.5 cm mass-like density in the anterior mediastinum which had not been previously visualized. Computed tomography scan (CT of the chest showed a right hilar mass encasing and narrowing right upper lobe bronchus and right mainstem bronchus and secondary atelectatic changes. Biopsy was consistent with a diagnosis of lymphomatoid granulomatosis Grade 3. She responded well clinically and radiologically to therapy. Lymphomatoid granulomatosis is a rare EBV-associated disorder which is considered a lymphoproliferative disease. The most common radiographic feature is multiple lung nodules. An isolated hilar mass is an exceptionally rare presentation of this rare disease.

  16. The ANCA Vasculitis Questionnaire (AAV-PRO©)

    Science.gov (United States)

    2017-05-01

    Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) (EGPA); Churg-Strauss Syndrome (CSS); Granulomatosis With Polyangiitis (Wegener's) (GPA); Wegener Granulomatosis (WG); Microscopic Polyangiitis (MPA); ANCA-Associated Vasculitis (AAV); Vasculitis

  17. Pulmonary lymphomatoid granulomatosis in seven dogs (1976-1987)

    International Nuclear Information System (INIS)

    Berry, C.R.; Moore, P.F.; Thomas, W.P.; Sisson, D.; Koblik, P.D.

    1990-01-01

    Seven dogs with pulmonary lymphomatoid granulomatosis were reviewed. The disease occurred in six large-breed and one small-breed dogs. The dogs were five to 14 years old (mean, 8.4; median, 7), and four of seven dogs were males. Three dogs had been previously treated with adulticide therapy for canine dirofilariasis. Clinical histories included a progressive respiratory disease characterized by varying degrees of cough, dyspnea, exercise intolerance, and weight loss. Thoracic radiographic features included hilar lymphadenopathy, pulmonary masses of varying sizes, and mixed pulmonary patterns of lobar consolidation with ill-defined interstitial and alveolar pulmonary infiltrates. Cardiovascular changes compatible with chronic dirofilariasis were present in three dogs. The clinical course was usually progressive and fatal. The survival time ranged from six days to four years (mean, 12.5 mos; median, 3 mos). Gross and histologic features included mass lesions with areas of necrosis that replaced normal pulmonary architecture. Cytologically, these lesions were characterized by infiltration with pleomorphic, angioinvasive mononuclear cells that often resulted in vascular obliteration. The infiltrating cells resembled large lymphoid cells that possessed large hyperchromatic nuclei and small amounts of cytoplasm. Systemic lymphoid neoplasia with peripheral lymphadenopathy was diagnosed in two dogs. In both cases, lymph-node cytology was similar to the cellular infiltrates found in the lungs and consistent with a diagnosis of lymphomatoid granulomatosis. These features are compared with previously reported cases of canine lymphomatoid granulomatosis and those features identified in a similar disease described in man

  18. Computerized tomography

    International Nuclear Information System (INIS)

    1980-01-01

    Improvements in the design of computerized tomographic X-ray equipment are described which lead to improvements in the mechanical properties, speed and size of scanning areas. The method envisages the body being scanned as a two-dimensional matrix of elements arising from a plurality of concentric rings. The concentric centre need not coincide with the axis of rotation. The procedures for rotation of the X-ray beam and detectors around the patient and for translating the measured information into attenuation coefficients for each matrix element of the body are described in detail. Explicit derivations are given for the mathematical formulae used. (U.K.)

  19. Esclerite nodular e poliangiite granulomatosa (Wegener mimetizando tuberculose

    Directory of Open Access Journals (Sweden)

    Cybelle Moreno Luize Franco

    2015-04-01

    Full Text Available Poliangiite granulomatosa é uma doença sistêmica que afeta qualquer órgão, com predileção pelo trato respiratório superior, pulmões e rins. Este artigo tem como objetivo relatar um caso atípico de uma paciente com esclerite nodular como manifestação inicial da poliangiite granulomatosa (Wegener, mimetizando um quadro de tuberculose. A paciente apresentou hiperemia ocular e baixa acuidade visual progressiva por 1,5 anos, seguido por dor ocular por dois meses. A paciente possuía nódulos subpleurais com densidade de partes moles, linfonodomegalia em janela aorto-pulmonar e espessamento pleural bilateral discreto, negativo para bacilos álcool-ácido resistentes (BAAR. O diagnóstico histológico revelou uma vasculite granulomatosa sugestiva de vasculite não infecciosa (poliangiite granulomatosa. Foi iniciada pulsoterapia com ciclofosfamida.

  20. Archive of Geosample Information from the Alfred-Wegener-Institut (AWI) Core Repository

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Alfred-Wegener-Institut (AWI) made a one-time contribution to the Index to Marine and Lacustrine Geological Samples (IMLGS) database of metadata describing 1820...

  1. Recurrence of Intravenous Talc Granulomatosis following Single Lung Transplantation

    Directory of Open Access Journals (Sweden)

    Richard C Cook

    1998-01-01

    Full Text Available Advanced pulmonary disease is an unusual consequence of the intravenous injection of oral medications, usually developing over a period of several years. A number of patients with this condition have undergone lung transplantation for respiratory failure. However, a history of drug abuse is often considered to be a contraindication to transplantation in the context of limited donor resources. A patient with pulmonary talc granulomatosis secondary to intravenous methylphenidate injection who underwent successful lung transplantation and subsequently presented with recurrence of the underlying disease in the transplanted lung 18 months after transplantation is reported.

  2. Eosinophilic Granulomatosis with Polyangiitis and Diffuse Gastrointestinal Involvement

    Directory of Open Access Journals (Sweden)

    Diana L. Franco

    2014-10-01

    Full Text Available Eosinophilic granulomatosis with polyangiitis (EGPA, formerly named Churg-Strauss syndrome, is a rare systemic small- and medium-sized-vessel vasculitis, characterized by the presence of severe asthma as well as blood and tissue eosinophilia. Gastrointestinal (GI symptoms, like diarrhea and abdominal pain, are common; however, there are few reports of histologic evidence of GI involvement. We report the case of a patient on treatment for EGPA who presented with recurrent small bowel obstruction and choledocholithiasis. Biopsies of the esophagus, small bowel and common bile duct showed diffuse eosinophilia, with clear EGPA in the GI tract. Improved awareness of GI EGPA may allow for timely management of this disorder.

  3. In vitro T lymphocyte responses to proteinase 3 (PR3) and linear peptides of PR3 in patients with Wegener's granulomatosis (WG)

    NARCIS (Netherlands)

    Van der Geld, YM; Huitema, MG; Franssen, CFM; Limburg, PC; Kallenberg, CGM; van der Zee, R.

    2000-01-01

    T cell-mediated immunity is thought to play an important role in the pathogenesis of WG. In previous studies a minority of WG patients as well as some healthy controls showed in vitro proliferation of their peripheral blood mononuclear cells (PBMC) to PR3, the main autoantigen in WG. The relevant

  4. Wegener’s granulomatosis of the breast: A case report

    International Nuclear Information System (INIS)

    Szabo-Moskal, Jadwiga

    2014-01-01

    Differential diagnosis and detection of malignant lesions in mammography poses a challenge for many diagnosticians. Although mammography continues to be the best and cost-effective way to detect breast cancer, it has its limitations due in part to the radiological appearance of changes of a very rare condition. We are presented with changes that have met well-known radiologic criteria for the diagnosis of malignancy, yet they turn out to be benign, because they belong to a group of extraordinary lesions. In June 2010, a 56-year-old woman found a lump in her right breast. Mammography performed at another medical center, revealed a change 12 mm in diameter, rated as BI-RADS 4C. Physical examination revealed a palpable lesion, 15 mm in diameter. Ultrasonography revealed hypoechogenic change with ill-defined outlines, size 14×10 mm – BI-RADS 5. Fine needle aspiration biopsy was done and revealed no atypical cells. The patient underwent an open surgical biopsy and a histopathological diagnosis was suggested to be a type of Wegener’s granulomatosis. Exclusion of cancer enabled the continuation of medical treatment of the underlying disease. There were no changes in the breast in follow-up studies. The differential diagnosis of breast tumors should include rare conditions that can sometimes mimic breast cancer. One of them is Wegener’s granulomatosis. Both, the diagnosis and treatment of the disease, require the cooperation of specialists from various fields, including clinicians, pathologists and radiologists

  5. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management

    NARCIS (Netherlands)

    Groh, Matthieu; Pagnoux, Christian; Baldini, Chiara; Bel, Elisabeth; Bottero, Paolo; Cottin, Vincent; Dalhoff, Klaus; Dunogué, Bertrand; Gross, Wolfgang; Holle, Julia; Humbert, Marc; Jayne, David; Jennette, J. Charles; Lazor, Romain; Mahr, Alfred; Merkel, Peter A.; Mouthon, Luc; Sinico, Renato Alberto; Specks, Ulrich; Vaglio, Augusto; Wechsler, Michael E.; Cordier, Jean-François; Guillevin, Loïc

    2015-01-01

    To develop disease-specific recommendations for the diagnosis and management of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) (EGPA). The EGPA Consensus Task Force experts comprised 8 pulmonologists, 6 internists, 4 rheumatologists, 3 nephrologists, 1 pathologist and 1

  6. [Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)].

    Science.gov (United States)

    Guillevin, Loïc

    2012-10-01

    Eosinophilic granulomatosis with polyangiitis (EGPA) (Churg-Strauss), is a rare necrotizing vasculitis of small-sized vessels, associated to antimyeloperoxydase ANCA in 40% of patients. EGPA occurs in patients with asthma. Asthma is sever, associated with eosinophilia and extrapulmonary symptoms. Among them, mononeuritis multiplex is the most frequent symptom. When cardiac involvement is present, prognosis is poor. Despite a good overall prognosis, deaths are caused by vasculitis activity, gastrointestinal and cardiac involvement. Treatment is well codified based on steroids, which are quickly effective. Immunosuppressants combined with corticosteroids are compulsory to treat the most sever forms, mainly when cardiac and gastrointestinal or renal symptoms are present. Copyright © 2012. Published by Elsevier Masson SAS.

  7. Granulomatosis with polyangiitis mimicking infective endocarditis in an adolescent male.

    Science.gov (United States)

    Varnier, Giulia Camilla; Sebire, Neil; Christov, Georgi; Eleftheriou, Despina; Brogan, Paul A

    2016-09-01

    Granulomatosis with polyangiitis (GPA) is a rare but serious small vessel vasculitis with heterogeneous clinical presentation ranging from mainly localised disease with a chronic course, to a florid, acute small vessel vasculitic form characterised by severe pulmonary haemorrhage and/or rapidly progressive vasculitis or other severe systemic vasculitic manifestations. Cardiac involvement is, however, uncommon in the paediatric population. We report a case of a 16-year-old male who presented with peripheral gangrene and vegetation with unusual location on the supporting apparatus of the tricuspid valve, initially considered to have infective endocarditis but ultimately diagnosed with GPA. We provide an overview of the limited literature relating to cardiac involvement in GPA, and the diagnostic challenge relating to infective endocarditis in this context, especially focusing on the interpretation of the antineutrophil cytoplasmic antibody (ANCA) and the characteristic clinical features to identify in order to promptly recognise GPA, since timely diagnosis and treatment are essential for this potentially life-threatening condition.

  8. Granulomatosis with polyangiitis confined to lacrimal gland, a case report.

    Science.gov (United States)

    Zuazo, F; González, M; Abdala, A; Olvera-Morales, O; Monroy, M H; Rodríguez-Reyes, A; Tovilla-Canales, J L; Nava-Castañeda, Á

    2017-11-01

    A 43 year-old woman consulted due to 2 months of swelling on the superolateral side of the left orbit, with pain and erythema. An excisional biopsy was performed that revealed vasculitis with polyangiitis of the lacrimal gland. A systemic study showed that no other system was compromised. Orbital involvement occurs in up to 60% of patients with granulomatosis with polyangiitis. The involvement of the lacrimal gland is rare and often unilateral. Serological tests are generally negative, both in initial stages, as in localized forms of the disease. Copyright © 2016 Sociedad Española de Oftalmología. Publicado por Elsevier España, S.L.U. All rights reserved.

  9. Validation and correction of rainfall data from the WegenerNet high density network in southeast Austria

    Science.gov (United States)

    O, Sungmin; Foelsche, U.; Kirchengast, G.; Fuchsberger, J.

    2018-01-01

    Eight years of daily rainfall data from WegenerNet were analyzed by comparison with data from Austrian national weather stations. WegenerNet includes 153 ground level weather stations in an area of about 15 km × 20 km in the Feldbach region in southeast Austria. Rainfall has been measured by tipping bucket gauges at 150 stations of the network since the beginning of 2007. Since rain gauge measurements are considered close to true rainfall, there are increasing needs for WegenerNet data for the validation of rainfall data products such as remote sensing based estimates or model outputs. Serving these needs, this paper aims at providing a clearer interpretation on WegenerNet rainfall data for users in hydro-meteorological communities. Five clusters - a cluster consists of one national weather station and its four closest WegenerNet stations - allowed us close comparison of datasets between the stations. Linear regression analysis and error estimation with statistical indices were conducted to quantitatively evaluate the WegenerNet daily rainfall data. It was found that rainfall data between the stations show good linear relationships with an average correlation coefficient (r) of 0.97 , while WegenerNet sensors tend to underestimate rainfall according to the regression slope (0.87). For the five clusters investigated, the bias and relative bias were - 0.97 mm d-1 and - 11.5 % on average (except data from new sensors). The average of bias and relative bias, however, could be reduced by about 80 % through a simple linear regression-slope correction, with the assumption that the underestimation in WegenerNet data was caused by systematic errors. The results from the study have been employed to improve WegenerNet data for user applications so that a new version of the data (v5) is now available at the WegenerNet data portal (www.wegenernet.org).

  10. Impact of Vasculitis on Employment and Income

    Science.gov (United States)

    2016-01-26

    Vasculitis; Systemic Vasculitis; Behcet's Disease; CNS Vasculitis; Cryoglobulinemic Vasculitis; Eosinophilic Granulomatosis; Temporal Arteritis; Wegener Granulomatosis; Henoch-Schoenlein Purpura; Microscopic Polyangiitis; Polyarteritis Nodosa (PAN); Takayasu's Arteritis; Urticarial Vasculitis

  11. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) presenting as diffuse myositis.

    Science.gov (United States)

    Parent, Marc-Etienne; Larue, Sandrine; Ellezam, Benjamin

    2014-11-21

    Eosinophilic granulomatosis with polyangiitis is a complex multisystemic syndrome with heterogeneous presentation. Most often, there is a clinical history of asthma or other atopic conditions, and current presentation generally includes signs of cutaneous or pulmonary involvement. Very few reports described myalgia or weakness as the chief complaint. Of these, only a few included muscle biopsy evaluation and none showed convincing evidence of primary myositis. We believe this report is the first to demonstrate true myositis in the setting of early eosinophilic granulomatosis with polyangiitis. This report describes a 74 year old Caucasian man, with no known allergies, presenting severe myalgia, muscle weakness, jaw claudication, and fever. Blood work showed marked eosinophilia and high creatine kinase levels. Biceps brachialis muscle biopsy revealed eosinophilic necrotizing vasculitis and true myositis with myophagocytosis of non-necrotic fibers and strong sarcolemmal MHC-1 overexpression by immunohistochemistry. This patient was successfully treated with prednisone and azathioprine. Our finding of true myositis in a case of eosinophilic granulomatosis with polyangiitis suggests that primary auto-immunity against muscle fibers, distinct from the secondary effects of vasculitis, can occur in this entity and may represent an overlap syndrome. Early recognition of eosinophilic granulomatosis with polyangiitis in patients presenting with myositis may provide an opportunity to treat the vasculitis before onset of severe multisystemic disease. We recommend the use of muscle biopsy with immunohistochemistry for MHC-1 to confirm the diagnosis of myositis in the setting of eosinophilic granulomatosis with polyangiitis.

  12. Lymphomatoid Granulomatosis: CT and FDG-PET Findings

    International Nuclear Information System (INIS)

    Chung, Jonathan H.; Wu, Carol C.; Gilman, Matthew D.; Palmer, Edwin L.; Hasserjian, Robert P.; Sphepar, Jo-Anne O.

    2011-01-01

    Lymphomatoid granulomatosis (LG) is a rare, aggressive extranodal Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disease. The purpose of our study was to analyze the CT and fluorodeoxyglucose positron emission tomography (FDG-PET) findings of pulmonary LG. Between 2000 and 2009, four patients with pathologically proven pulmonary LG and chest CT were identified. Two of these patients also had FDG-PET. Imaging features of LG on CT and PET were reviewed. Pulmonary nodules or masses with peribronchovascular, subpleural, and lower lung zonal preponderance were present in all patients. Central low attenuation (4 of 4 patients), ground-glass halo (3 of 4 patients), and peripheral enhancement (4 of 4 patients) were observed in these nodules and masses. An air-bronchogram and cavitation were seen in three of four patients. FDG-PET scans demonstrated avid FDG uptake in the pulmonary nodules and masses. Pulmonary LG presents with nodules and masses with a lymphatic distribution, as would be expected for a lymphoproliferative disease. However, central low attenuation, ground-glass halo and peripheral enhancement of the nodules/masses are likely related to the angioinvasive nature of this disease. Peripheral enhancement and ground-glass halo, in particular, are valuable characteristic not previously reported that can help radiologists suggest the diagnosis of pulmonary LG.

  13. Lymphomatoid Granulomatosis: CT and FDG-PET Findings

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Jonathan H. [National Jewish Health, Denver (United States); Wu, Carol C.; Gilman, Matthew D.; Palmer, Edwin L.; Hasserjian, Robert P.; Sphepar, Jo-Anne O. [Massachusetts General Hospital, Boston (United States)

    2011-11-15

    Lymphomatoid granulomatosis (LG) is a rare, aggressive extranodal Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disease. The purpose of our study was to analyze the CT and fluorodeoxyglucose positron emission tomography (FDG-PET) findings of pulmonary LG. Between 2000 and 2009, four patients with pathologically proven pulmonary LG and chest CT were identified. Two of these patients also had FDG-PET. Imaging features of LG on CT and PET were reviewed. Pulmonary nodules or masses with peribronchovascular, subpleural, and lower lung zonal preponderance were present in all patients. Central low attenuation (4 of 4 patients), ground-glass halo (3 of 4 patients), and peripheral enhancement (4 of 4 patients) were observed in these nodules and masses. An air-bronchogram and cavitation were seen in three of four patients. FDG-PET scans demonstrated avid FDG uptake in the pulmonary nodules and masses. Pulmonary LG presents with nodules and masses with a lymphatic distribution, as would be expected for a lymphoproliferative disease. However, central low attenuation, ground-glass halo and peripheral enhancement of the nodules/masses are likely related to the angioinvasive nature of this disease. Peripheral enhancement and ground-glass halo, in particular, are valuable characteristic not previously reported that can help radiologists suggest the diagnosis of pulmonary LG.

  14. Acute laryngeal dyspnea as first presentation of granulomatosis with polyangiitis.

    Science.gov (United States)

    Pajor, Anna Maria; Kwiatkowska, Sylwia; Kroczyńska-Bednarek, Jadwiga; Piotrowski, Wojciech J

    2015-01-01

    Granulomatosis with polyangiitis (GPA) is a multi-organ disease which mostly affects lungs, kidney, and head and neck region. We report a rare case of acute laryngeal dyspnea and rapidly progressive pulmonary changes as first manifestations of disease. A 53 year-old woman presented with symptoms of two-week dyspnea, which aggravated rapidly in the preceding hours. Laryngological examination revealed subglottic infiltrations and vocal fold oedema which required urgent tracheotomy. During few days she developed gingival ulcerations and pulmonary infiltration with negative serum c-ANCA titers. The histopathological examination of subglottic and gingival biopsies and the clinical picture established the diagnosis of GPA. She was treated with prednisone and cyclophosphamide with recovery; however, during over 3 years of follow-up, pulmonary symptoms relapsed and subglottic stenosis persisted. The difficulties in diagnosis and treatment in this unusual presentation of GPA are outlined with conclusion that in patients with subglottic infiltration, which develops rapidly, even when this is a sole presentation of the disease, and when c-ANCA are negative, GPA should always be considered.

  15. Wegener’s granulomatosis mimicking inflammatory bowel disease and presenting with chronic enteritis

    Directory of Open Access Journals (Sweden)

    Shahedi K

    2013-10-01

    Full Text Available Kamyar Shahedi,1,2 Ramy Magdy Hanna,1,2 Oleg Melamed,1,2 James Wilson2,31Department of Medicine Olive-View UCLA Medical Center, Sylmar, CA, 2David Geffen School of Medicine at UCLA, Los Angeles, CA, 3UCLA Medical Center-UCLA Stone Center, Los Angeles, CA, USAAbstract: Wegener’s granulomatosis, also known as anti-neutrophil cytoplasmic antibody (ANCA-associated vasculitis, is a small vessel vasculitis with primarily pulmonary, renal, and sinus disease manifestations. The prevalence of Wegener’s granulomatosis is three cases per 100,000 patients. Cardiovascular, neurologic, cutaneous, and joint manifestations have been reported in many case reports and case series. Gastrointestinal manifestations are less noted in Wegener’s granulomatosis, although they have been previously reported in the form of intestinal perforation and intestinal ischemia. Additionally, there are characteristic findings of vasculitis that are noted with active Wegener’s granulomatosis of the small bowel. We report a case of an elderly patient who presented with weight loss, diarrhea, and hematochezia. His symptoms were chronic and had lasted for more than 1 year before diagnosis. Inflammatory bowel disease or chronic enteritis due to Salmonella arizonae because of reptile exposure originally were suspected as etiologies of his presentation. The findings of proteinuria, renal failure, and pauci-immune glomerulonephritis on renal biopsy, in conjunction with an elevated c-ANCA titer, confirmed the diagnosis of Wegener’s granulomatosis with associated intestinal vasculitis. This case demonstrates an atypical presentation of chronic duodenitis and jejunitis secondary to Wegener’s granulomatosis, which mimicked inflammatory bowel disease.Keywords: ANCA-associated vasculitis, Wegener’s syndrome, pauci-immune glomerulonephritis, Salmonella arizonae, inflammatory bowel disease

  16. THE 2015 INTERNATIONAL GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS

    Directory of Open Access Journals (Sweden)

    T. V. Beketova

    2016-01-01

    Full Text Available In 2015, guidelines for the diagnosis and treatment of eosinophilic granulomatosis with polyangiitis, formerly known as Churg-Strauss syndrome, were prepared with the participation of experts from 5 countries of Europe, the USA, and Canada, who accumulated scientific achievements and currently gained clinical experience. The proposed guidelines should not be regarded as final standards, but must become a guide for the selection of a personification strategy for managing patients with eosinophilic granulomatosis with polyangiitis and serve as a starting point for further investigations. The purposes of the publication are general characterization of the key points of the guidelines and discussion of some debate problems. 

  17. Focus on audiologic impairment in eosinophilic granulomatosis with polyangiitis.

    Science.gov (United States)

    Seccia, Veronica; Fortunato, Susanna; Cristofani-Mencacci, Lodovica; Dallan, Iacopo; Casani, Augusto P; Latorre, Manuela; Paggiaro, Pierluigi; Bartoli, Maria Laura; Sellari-Franceschini, Stefano; Baldini, Chiara

    2016-12-01

    To evaluate the clinical features of audiologic impairment and its relationship with the nasal, vestibular, and rheumatologic profile in a cohort of patients with eosinophilic granulomatosis with polyangiitis (EGPA), formerly named Churg-Strauss syndrome. Prospective cross-sectional study. Thirty-nine patients with EGPA, considered controlled according to the Birmingham Vasculitis Activity Score and the Vasculitis Damage Index, underwent a complete audiologic evalutaion with otomicroscopy, impedance audiometry, speech audiometry, and auditory brainstem responses; rhinologic evaluation was made by means of fiberoptic endoscopy and nasal cytology; the clinical evaluation was completed with analysis of the facial function and, in patients with referred vertigo, with videonystagmography (VNG). Data were compared to the rheumatologic profile (eosinophil count, antineutrophil cytoplasmic antibodies status). Thirty-four of 39 patients fulfilled the inclusion criteria. Of those, 18 (52, 8%) were affected by variable degrees of hearing loss (sensorineural hearing loss [SNHL]) in four cases (11, 8%), mixed sensorineural and conductive hearing loss in two (5, 9%), presbycusis in six (17, 6%), and otitis media with effusion (OME) in six (17, 6%). Vestibular impairment was represented by benign paroxysmal positional vertigo and unspecific dizziness in three (8, 8%) and four cases (11, 8%), respectively, all with normal VNG. Ear involvement was statistically related to the EGPA vasculitic pattern and independent from the nasal impairment, cytology, and duration of nasal symptoms. No facial palsy was registered. In our experience, the largest in the existing literature, the otological involvement in EGPA is common and may occur variably as SNHL or OME. Otological involvement occurs early in the course of the disease process, but is nonspecific in making the diagnosis of EGPA. Its recognition is therefore fundamental. 4. Laryngoscope, 126:2792-2797, 2016. © 2016 The American

  18. Review article: cinnamon- and benzoate-free diet as a primary treatment for orofacial granulomatosis.

    Science.gov (United States)

    Campbell, H E; Escudier, M P; Patel, P; Challacombe, S J; Sanderson, J D; Lomer, M C E

    2011-10-01

    Orofacial granulomatosis is a rare chronic granulomatous inflammatory disease of the lips, face and mouth. The aetiology remains unclear but may involve an allergic component. Improvements have been reported with cinnamon- and benzoate-free diets. To explore the prevalence of compound and food sensitivity and examine the dietary treatments used in orofacial granulomatosis. A comprehensive literature search was carried out and relevant studies from January 1933 to January 2010 were identified using the electronic database search engines; AGRIS 1991-2008, AMED 1985-2008, British Nursing and Index archive 1985-2008, EMBASE 1980-2008, evidence based medicine review databases (e.g. Cochrane DSR), International Pharmaceutical and Medline 1950-2008. Common sensitivities identified, predominantly through patch testing, were to benzoic acid (36%) food additives (33%), perfumes and flavourings (28%), cinnamaldehyde (27%), cinnamon (17%), benzoates (17%) and chocolate (11%). The cinnamon- and benzoate-free diet has been shown to provide benefit in 54-78% of patients with 23% requiring no adjunctive therapies. A negative or positive patch test result to cinnamaldehyde, and benzoates did not predict dietary outcome. The most concentrated source of benzoate exposure is from food preservatives. Use of liquid enteral formulas can offer a further dietary therapy, particularly in children with orofacial granulomatosis. Management of orofacial granulomatosis is challenging but cinnamon- and benzoate-free diets appear to have a definite role to play. © 2011 Blackwell Publishing Ltd.

  19. Eosinophilic granulomatosis with polyangitis (Churg-Strauss syndrome: a diagnostic rarity with an atypical presentation

    Directory of Open Access Journals (Sweden)

    Sujeet Raina

    2014-01-01

    Full Text Available We report a case of a 33-year-old woman who presented to us with symptoms of bronchial asthma and peripheral neuropathy. After investigations, the diagnosis of eosinophilic granulomatosis and polyangitis (Churg-Strauss syndrome was made.

  20. Serum 25-hydroxyvitamin D levels in patients with Granulomatosis with Polyangiitis: association with respiratory infection

    Directory of Open Access Journals (Sweden)

    Mariana O. Perez

    Full Text Available OBJECTIVES: To determine the possible association of serum 25-hydroxyvitamin D (25OHD levels with disease activity and respiratory infection in granulomatosis with polyangiitis patients during two different periods: winter/spring and summer/autumn. METHODS: Thirty-two granulomatosis with polyangiitis patients were evaluated in the winter/spring, and the same patients (except 5 were evaluated in summer/autumn (n=27. The 25OHD levels were measured by radioimmunoassay. Disease activity was assessed by the Birmingham Vasculitis Activity Score Modified for Wegener’s Granulomatosis (BVAS/WG and antineutrophil cytoplasmic antibody (ANCA positivity. Respiratory infection was defined according the Centers for Disease Control and Prevention criteria. RESULTS: 25OHD levels were lower among patients in winter/spring than in summer/autumn (32.31±13.10 vs. 38.98±10.97 ng/mL, p=0.04. Seven patients met the criteria for respiratory infection: 5 in winter/spring and 2 in summer/autumn. Patients with respiratory infection presented lower 25OHD levels than those without infection (25.15±11.70 vs. 36.73±12.08 ng/mL, p=0.02. A higher frequency of low vitamin D levels (25OHD<20 ng/mL was observed in patients with respiratory infection (37.5% vs. 7.8, p=0.04. Serum 25OHD levels were comparable between patients with (BVAS/WG≥1 plus positive ANCA and without disease activity (BVAS/WG=0 plus negative ANCA (35.40±11.48 vs. 35.34±13.13 ng/mL, p=0.98. CONCLUSIONS: Lower 25OHD levels were associated with respiratory infection but not disease activity in granulomatosis with polyangiitis patients. Our data suggest that hypovitaminosis D could be an important risk factor for respiratory infection in granulomatosis with polyangiitis patients.

  1. An atypical presentation of cardiac tamponade and periorbital swelling in a patient with eosinophilic granulomatosis with polyangiitis: a case report.

    Science.gov (United States)

    Keefe, Alexandra C; Hymas, Joseph C; Emerson, Lyska L; Ryan, John J

    2017-09-24

    Eosinophilic granulomatosis with polyangiitis is a rare, necrotizing systemic vasculitis associated with asthma and hypereosinophilia. Its cause and pathophysiology are still being elucidated. We report a case of eosinophilic granulomatosis with polyangiitis in a 50-year-old Caucasian woman who presented with chest pain, dyspnea at rest, fever, and periorbital swelling. She was found to have significant hypereosinophilia and cardiac tamponade physiology. A biopsy confirmed extensive infiltration of both lungs and pericardium by eosinophils. She did not have any anti-neutrophil cytoplasmic antibodies. Eosinophilic granulomatosis with polyangiitis diagnosis does not require the presence of anti-neutrophil cytoplasmic antibodies. Anti-neutrophil cytoplasmic antibody-positive and anti-neutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis may present with different clinical phenotypes, perhaps suggesting two distinct disease etiologies and distinct pathophysiology.

  2. Celebral computerized tomography

    International Nuclear Information System (INIS)

    Lofteroed, B.; Sortland, O.

    1985-01-01

    Indications for cerebral computerized tomography (CT) and the diagnostic results from this examination are evaluated in 127 children. Pathological changes were found in 31 children, mostly based on such indications as increasing head size, suspicion of brain tumor, cerebral paresis, delayed psychomotor development and epileptic seizures. A list of indications for CT in children is given

  3. Computerized industrial tomography

    International Nuclear Information System (INIS)

    Ashraf, M.M.

    1999-01-01

    Computerized Tomographic (CT) has been used for a number of applications in the field of medicine and industry. For the last couple of years, the technique has been applied for the material characterization and detection of defects and flaws inside the industrial components of nuclear, aerospace and missile industries. A CT scanner of first generation was developed at the institute. The scanner has been used to demonstrate couple of applications of CT in the field of non destructive testing of materials. The data acquired by placing the test objects at various angles and scanning the object through a source detector assembly has been processed on a Pentium computer for image reconstruction using a filtered back projection method. The technique has been developed which can be modified and improved to study various other applications in materials science and a modern computerized tomographic facility can be established. (author)

  4. Highly resolving computerized tomography

    International Nuclear Information System (INIS)

    Kurtz, B.; Petersen, D.; Walter, E.

    1984-01-01

    With the development of highly-resolving devices for computerized tomography, CT diagnosis of the lumbar vertebral column has gained increasing importance. As an ambulatory, non-invasive method it has proved in comparative studies to be at least equivalent to myelography in the detection of dislocations of inter-vertebral disks (4,6,7,15). Because with modern devices not alone the bones, but especially the spinal soft part structures are clearly and precisely presented with a resolution of distinctly below 1 mm, a further improvement of the results is expected as experience will increase. The authors report on the diagnosis of the lumbar vertebral column with the aid of a modern device for computerized tomography and wish to draw particular attention to the possibility of doing this investigation as a routine, and to the diagnostic value of secondary reconstructions. (BWU) [de

  5. Highly resolving computerized tomography

    Energy Technology Data Exchange (ETDEWEB)

    Kurtz, B.; Petersen, D.; Walter, E.

    1984-01-01

    With the development of highly-resolving devices for computerized tomography, CT diagnosis of the lumbar vertebral column has gained increasing importance. As an ambulatory, non-invasive method it has proved in comparative studies to be at least equivalent to myelography in the detection of dislocations of inter-vertebral disks (4,6,7,15). Because with modern devices not alone the bones, but especially the spinal soft part structures are clearly and precisely presented with a resolution of distinctly below 1 mm, a further improvement of the results is expected as experience will increase. The authors report on the diagnosis of the lumbar vertebral column with the aid of a modern device for computerized tomography and wish to draw particular attention to the possibility of doing this investigation as a routine, and to the diagnostic value of secondary reconstructions.

  6. Computerized plant maintenance management

    International Nuclear Information System (INIS)

    Kozusko, A.M.

    1986-01-01

    The evolution of the computer has and continues to have a great impact on industry. We are in an adjustment cycle with the current computer evolution, and will need to adapt to make the changes for the coming decade. Hardware and software are continually being enhanced. Computers are becoming more powerful and will eventually provide an effective man-machine interface. This paper shares experiences encountered during implementations of computerized maintenance systems

  7. Computerized medical convocations

    International Nuclear Information System (INIS)

    Roche, Annie; Gilbert, Jean-Francois; Chiadot, Pierre; Vanzetto, Rene; Darnault, Jean

    1969-06-01

    Thanks to a close collaboration between the Medical and Social department and the Numerical Calculation Laboratory, a computerized convocation system has been implemented to reduce the administrative workload and to introduce more rigor in medical management, patient historical background and statistics. This work comprises: - a preliminary study of the data generating medical convocations and the related practical requirements; - the programming work according to these data; - the realisation of the mechano-graphical file covering the overall personnel [fr

  8. Orofacial granulomatosis in children can be the initial manifestation of systemic disease: a presentation of two cases

    DEFF Research Database (Denmark)

    Simonsen, Anne Birgitte; Deleuran, Mette

    2014-01-01

    Orofacial granulomatosis is a chronic granulomatous condition characterized by relapsing and remitting lip swelling and oral involvement that may include deep ulcers, tags and cobblestone formation. It occurs as an independent entity but also in conjunction with systemic diseases...... such as tuberculosis, sarcoidosis and Crohn's disease. The clinical presentation is not indicative of concomitant systemic disease. To highlight the importance of thorough examination to rule out systemic disease, we present two childhood cases of orofacial granulomatosis, one of which was associated to Crohn......'s disease....

  9. Wegner′s granulomatosis developing for the first time in a patient eight years after starting maintenance hemodialysis

    Directory of Open Access Journals (Sweden)

    Ahmad Ramadan Ali

    2015-01-01

    Full Text Available Wegener′s granulomatosis is a serious autoimmune disorder characterized by necrotizing small-vessel vasculitis. It is a multisystem disease that primarily affects the lung and kidneys. Previous studies indicated few relapses of vasculitis after hemodialysis due to uremic immunosuppression. Our case report describes an end-stage renal failure patient who had developed non-caseating lung granulomata with giant cell formation and fibrinoid necrosis of arterial media that is consistent with Wegner′s granulomatosis for the first time and eight years after initiation of maintenance hemodialysis. We believe that such a phenomenon has rarely been reported.

  10. Successful application of extracorporeal membrane oxygenation due to pulmonary hemorrhage secondary to granulomatosis with polyangiitis

    Directory of Open Access Journals (Sweden)

    Hohenforst-Schmidt W

    2013-07-01

    Full Text Available Wolfgang Hohenforst-Schmidt,1 Arndt Petermann,2 Aikaterini Visouli,3 Paul Zarogoulidis,4 Kaid Darwiche,5 Ioanna Kougioumtzi,6 Kosmas Tsakiridis,3 Nikolaos Machairiotis,6 Markus Ketteler,2 Konstantinos Zarogoulidis,4 Johannes Brachmann11II Medical Clinic, Coburg Clinic, University of Wuerzburg, Coburg, Germany; 2Division of Nephrology, Coburg Clinic, University of Wuerzburg, Coburg, Germany; 3Cardiothoracic Surgery Department, “Saint Luke” Private Hospital, Thessaloniki, Greece; 4Pulmonary Department, “G Papanikolaou” General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 5Department of Interventional Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital, University of Duisburg-Essen, Essen, Germany; 6Surgery Department (National Health System, University General Hospital of Alexandroupolis, Alexandroupolis, GreeceAbstract: Extracorporeal membrane oxygenation (ECMO is increasingly applied in adults with acute refractory respiratory failure that is deemed reversible. Bleeding is the most frequent complication during ECMO support. Severe pre-existing bleeding has been considered a contraindication to ECMO application. Nevertheless, there are cases of successful ECMO application in patients with multiple trauma and hemorrhagic shock or head trauma and intracranial hemorrhage. ECMO has proved to be life-saving in several cases of life-threatening respiratory failure associated with pulmonary hemorrhage of various causes, including granulomatosis with polyangiitis (Wegener’s disease. We successfully applied ECMO in a 65-year-old woman with acute life-threatening respiratory failure due to diffuse massive pulmonary hemorrhage secondary to granulomatosis with polyangiitis, manifested as severe pulmonary-renal syndrome. ECMO sustained life and allowed disease control, together with plasmapheresis, cyclophosphamide, corticoids, and renal replacement therapy. The patient was successfully weaned from ECMO

  11. Pulmonary gallium uptake in rats with granulomatosis induced by complete Freund adjuvant

    International Nuclear Information System (INIS)

    Stanislas-Leguern, G.; Masse, R.; Jaubert, F.; Chretien, J.; Huchon, G.

    1988-01-01

    To investigate the mechanism of gallium-67 uptake in lung granulomatosis, we studied 13 rats in which lung granulomatosis was induced by injection of complete Freund adjuvant (CFA) and 14 controls. Gallium uptake was assessed in bronchoalveolar lavage fluid and lavaged lung. The cells responsible for gallium uptake were identified by latent image activation autoradiography. Gallium activity in both lavaged lungs and bronchoalveolar cells (BAC) was higher in CFA-treated animals than in controls [172,205 +/- 134,783 DPM versus 44,456 +/- 14,486 DPM +/- SD (p less than 0.05) and 40,083 +/- 16,350 DPM versus 9100 +/- 4114 DPM (p less than 0.05), respectively]. In control rats, about two-thirds of total lung gallium was located in the interstitium, whereas in CFA-treated rats it was found in the mononuclear cells of lung granulomas. Gallium tracks were more numerous in the alveolar macrophages (AM) of CFA-treated rats than in control AM (28.4 +/- 10.0/field versus 8.4 +/- 3.8/field, p less than 0.001) but the number of tracks was proportional to the number of AM (52.4 +/- 18.7 versus 12.2 +/- 4.3, respectively; p less than 0.001). It is concluded that in rats with CFA-induced lung granulomatosis 1) pulmonary gallium uptake increases, 2) mononuclear cells are responsible for this uptake in both granulomas and AM, and 3) the increased uptake is due to the increased number of mononuclear cells

  12. Computerized operator decision aids

    International Nuclear Information System (INIS)

    Long, A.B.

    1984-01-01

    This article explores the potential benefits associated with the use of computers in nuclear plants by the operating crew as an aid in making decisions. Pertinent findings are presented from recently completed projects to establish the context in which operating decisions have to be made. Key factors influencing the decision-making process itself are also identified. Safety parameter display systems, which are being implemented in various forms by the nuclear industry, are described within the context of decision making. In addition, relevant worldwide research and development activities are examined as potential enhancements to computerized operator decision aids to further improve plant safety and availability

  13. Computerized procedures system

    Science.gov (United States)

    Lipner, Melvin H.; Mundy, Roger A.; Franusich, Michael D.

    2010-10-12

    An online data driven computerized procedures system that guides an operator through a complex process facility's operating procedures. The system monitors plant data, processes the data and then, based upon this processing, presents the status of the current procedure step and/or substep to the operator. The system supports multiple users and a single procedure definition supports several interface formats that can be tailored to the individual user. Layered security controls access privileges and revisions are version controlled. The procedures run on a server that is platform independent of the user workstations that the server interfaces with and the user interface supports diverse procedural views.

  14. Computerized spleen volumetry

    International Nuclear Information System (INIS)

    Jahnke, T.; Mohring, R.; Schertel, L.

    1981-01-01

    We examined in experimental studies and clinical investigations on 34 patients in how far volumetry of the spleen can be carried out with a commonly available program, a whole-body computerized tomograph (SOMATOM) and an analytic equipment (EVALUSKOP). In this connection the authors tried to find also other ways of spleen volumetry by means of this unit combination. Our final result was that the given program for the usage of labelled areas presents itself as the best-suited technique for spleen volumetry which is also applicable in practice. (orig./MG) [de

  15. Computerized adaptive testing item selection in computerized adaptive learning systems

    NARCIS (Netherlands)

    Eggen, Theodorus Johannes Hendrikus Maria; Eggen, T.J.H.M.; Veldkamp, B.P.

    2012-01-01

    Item selection methods traditionally developed for computerized adaptive testing (CAT) are explored for their usefulness in item-based computerized adaptive learning (CAL) systems. While in CAT Fisher information-based selection is optimal, for recovering learning populations in CAL systems item

  16. Successful endonasal dacryocystorhinostomy in a patient with Wegener’s granulomatosis

    Directory of Open Access Journals (Sweden)

    P Eloy

    2009-11-01

    Full Text Available P Eloy, E Leruth, B Bertrand, Ph RombauxENT and HNS department, Cliniques Universitaires de Mont-Godinne, Université Catholique de Louvain, 5530, Yvoir, BelgiumAbstract: Wegener’s granulomatosis (WG is one form of idiopathic autoimmune vasculitis. The disease has a predilection for the upper and lower respiratory tracts (lungs, nose, sinus, and kidneys. WG may be systemic, severe, and potentially lethal, but it may also be limited to the otolaryngological area or to the eyes and the orbits. Obstruction of the lacrimal pathway is a possible complication of the disease that affects approximately 7% of patients with WG. It usually occurs as a direct extension of sinonasal disease and typically is a late manifestation. Management of such a condition is generally viewed as difficult. We report the case of a patient with a quiescent WG limited to the otolaryngological area. This patient presented a bilateral obstruction of the nasolacrimal ducts caused by bilateral extensive adhesions in the nasal cavity. Because she had several episodes of left-side acute dacryocystitis which necessitated several courses of broad-spectrum antibiotics, she successfully underwent an endonasal endoscopic dacryocystorhinostomy using a diode laser and powered instrumentation. The authors describe the clinical case, the surgical technique, and review the literature.Keywords: Wegener’s granulomatosis, recurrent dacryocystitis, endonasal DCR, diode, laser, powered instrumentation

  17. Pulmonary talc granulomatosis mimicking malignant disease 30 years after last exposure: a case report

    Directory of Open Access Journals (Sweden)

    Krimsky William S

    2008-07-01

    Full Text Available Abstract Introduction Pulmonary talc granulomatosis is a rare disorder characterized by the development of foreign body granuloma secondary to talc exposure. Previous case reports have documented the illness in current intravenous drug users who inject medications intended for oral use. We present a rare case of the disease in a patient with a distant history of heroin abuse who presented initially with history and imaging findings highly suggestive of malignancy. Case presentation A 53-year-old man reported a 4-month history of increasing dyspnea and weight loss. He had a long history of smoking and admission chest X-ray revealed a density in the right hemithorax. Computed tomography confirmed a probable mass with further speculated opacities in both lung fields suspicious for malignant spread. Biopsies obtained using endobronchial ultrasound-guided aspiration returned negative for malignancy and showed bronchial epithelial cells with foreign body giant cell reaction and polarizable birefringent talc crystals. Conclusion This case demonstrates a rare presentation of talc granulomatosis three decades after the last likely exposure. The history and imaging findings in a chronic smoker were initially strongly suggestive of malignant disease, and we recommend that talc-induced lung disease is considered in any patient with multiple scattered pulmonary lesions and a history of intravenous drug use. Confirmation of the disease by biopsy is essential, but unfortunately there are few successful proven management options for patients with worsening disease.

  18. Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure

    NARCIS (Netherlands)

    Glasner, Corinna; van Timmeren, Mirjan M; Stobernack, Tim; Omansen, Till F; Raangs, Gerwin; Rossen, John W; de Goffau, Marcus C; Arends, Jan P; Kampinga, Greetje A; Koedijk, Danny; Neef, Jolanda; Buist, Girbe; Tavakol, Mehri; van Wamel, Willem J B; Rutgers, Abraham; Stegeman, Coen A; Kallenberg, Cornelis; Heeringa, Peter; van Dijl, Jan Maarten

    2015-01-01

    Chronic nasal carriage of the bacterium Staphylococcus aureus in patients with the autoimmune disease granulomatosis with polyangiitis (GPA) is a risk factor for disease relapse. To date, it was neither known whether GPA patients show similar humoral immune responses to S. aureus as healthy

  19. Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure

    NARCIS (Netherlands)

    C. Glasner (Corinna); M.M. Van Timmeren (Mirjan M.); T. Stobernack (Tim); T.F. Omansen (Till F.); E.C. Raangs (Erwin C.); J.W. Rossen (John); M.C. De Goffau (Marcus C.); J.P.A. Arends (Jan); G.A. Kampinga (Greetje); D.G.A.M. Koedijk (Denny); J. Neef (Jolanda); G. Buist (Girbe); M. Tavakol (Mehri); W.J.B. van Wamel (Willem); A. Rutgers (Abraham); C.A. Stegeman; C.G.M. Kallenberg (Cees G. M.); P. Heeringa (Peter); J.M. Dijl (Jan Maarten)

    2015-01-01

    textabstractChronic nasal carriage of the bacterium Staphylococcus aureus in patients with the autoimmune disease granulomatosis with polyangiitis (GPA) is a risk factor for disease relapse. To date, it was neither known whether GPA patients show similar humoral immune responses to S. aureus as

  20. Computerized tomographic system

    International Nuclear Information System (INIS)

    Godbarsen, R.; Barrett, D.M.; Garrott, P.M.; Foley, L.E.; Redington, R.W.; Lambert, T.W.; Edelheit, L.S.

    1981-01-01

    A computerized tomographic system for examining human breasts is described in detail. Conventional X-ray scanning apparatus has difficulty in achieving the levels of image definition and examination speeds required for mass screening. A novel method of scanning successive layers of the breast with a rotating X-ray beam is discussed and details of the control circuitry and sequence steps are given. The method involves immersing the breast in an inner fluid (e.g. water) filled container which is stationary during an examination and is surrounded by a large outer container which is also filled with the fluid; the inner and outer containers are always maintained at a constant height and the X-ray absorption across the fan-shaped beam is as close as possible to constant. (U.K.)

  1. The Wegener-Bergeron-Findeisen process – Its discovery and vital importance for weather and climate

    Directory of Open Access Journals (Sweden)

    Trude Storelvmo

    2015-04-01

    Full Text Available The Wegener-Bergeron-Findeisen process refers to the rapid growth of ice crystals at the expense of surrounding cloud droplets, which frequently occurs in atmospheric mixed-phase clouds. The process is a result of the difference in saturation vapor pressures with respect to liquid and ice, and may in some circumstances lead to abrupt and complete cloud glaciation at temperatures between −40 °C and 0 °C in the Earth's atmosphere. The process is named after three eminent scientists who were active in the first half of the 20th century, among them being German meteorologist Walter Findeisen (1909–1945. In his classical paper published in 1938, Findeisen described the contemporary understanding of the Wegener-Bergeron-Findeisen process and other key cloud microphysical processes. Here, we compare the understanding of the aforementioned processes at the time with that of the present, and find that they are remarkably similar. We also discuss how the Wegener-Bergeron-Findeisen process is implemented in state-of-the-art numerical models of the atmosphere, and highlight its importance for both weather and climate.

  2. Neumayer III and Kohnen Station in Antarctica operated by the Alfred Wegener Institute

    Directory of Open Access Journals (Sweden)

    Christine Wesche

    2016-08-01

    Full Text Available The Alfred Wegener Institute operates two stations in Dronning Maud Land, Antarctica. The German overwintering station Neumayer III is located on the Ekström Ice Shelf at 70°40’S and 08°16’W and is the logistics base for three long-term observatories (meteorology, air chemistry and geophysics and nearby research activities. Due to the vicinity to the coast (ca. 20 km from the ice shelf edge, the Neumayer III Station is the junction for many German Antarctic expeditions, especially as the starting point for the supply traverse for the second German station Kohnen. The summer station Kohnen is located about 600 km from the coast and 750 km from Neumayer III Station on the Antarctic plateau at 75°S and 00°04’E. It was erected as the base for the deep-drilling ice core project, which took place between 2001 and 2006. Since then Kohnen Station is used as a logistics base for different research projects.

  3. Modeling of the Wegener-Bergeron-Findeisen process-implications for aerosol indirect effects

    International Nuclear Information System (INIS)

    Storelvmo, T; Lohmann, U; Kristjansson, J E; Iversen, T; Kirkevaag, A; Seland, O

    2008-01-01

    A new parameterization of the Wegener-Bergeron-Findeisen (WBF) process has been developed, and implemented in the general circulation model CAM-Oslo. The new parameterization scheme has important implications for the process of phase transition in mixed-phase clouds. The new treatment of the WBF process replaces a previous formulation, in which the onset of the WBF effect depended on a threshold value of the mixing ratio of cloud ice. As no observational guidance for such a threshold value exists, the previous treatment added uncertainty to estimates of aerosol effects on mixed-phase clouds. The new scheme takes subgrid variability into account when simulating the WBF process, allowing for smoother phase transitions in mixed-phase clouds compared to the previous approach. The new parameterization yields a model state which gives reasonable agreement with observed quantities, allowing for calculations of aerosol effects on mixed-phase clouds involving a reduced number of tunable parameters. Furthermore, we find a significant sensitivity to perturbations in ice nuclei concentrations with the new parameterization, which leads to a reversal of the traditional cloud lifetime effect.

  4. Modeling of the Wegener Bergeron Findeisen process—implications for aerosol indirect effects

    Science.gov (United States)

    Storelvmo, T.; Kristjánsson, J. E.; Lohmann, U.; Iversen, T.; Kirkevåg, A.; Seland, Ø.

    2008-10-01

    A new parameterization of the Wegener-Bergeron-Findeisen (WBF) process has been developed, and implemented in the general circulation model CAM-Oslo. The new parameterization scheme has important implications for the process of phase transition in mixed-phase clouds. The new treatment of the WBF process replaces a previous formulation, in which the onset of the WBF effect depended on a threshold value of the mixing ratio of cloud ice. As no observational guidance for such a threshold value exists, the previous treatment added uncertainty to estimates of aerosol effects on mixed-phase clouds. The new scheme takes subgrid variability into account when simulating the WBF process, allowing for smoother phase transitions in mixed-phase clouds compared to the previous approach. The new parameterization yields a model state which gives reasonable agreement with observed quantities, allowing for calculations of aerosol effects on mixed-phase clouds involving a reduced number of tunable parameters. Furthermore, we find a significant sensitivity to perturbations in ice nuclei concentrations with the new parameterization, which leads to a reversal of the traditional cloud lifetime effect.

  5. Computerized tomography in myotonic dystrophy

    International Nuclear Information System (INIS)

    Gellerich, I.; Mueller, D.; Koch, R.D.

    1986-01-01

    Besides clinical symptoms, progress and electromyography computerized tomography improves the diagnostics of myotonic dystrophy. Even small changes in muscular structure are detectable and especially the musculus soleus exhibits early and pronounced alterations. By means of density distribution pattern an improved characterization of the disease is possible. Additional information is obtained by cerebral computerized tomography. Atrophy of brain tissue is to be expected in all patients with myotonic dystrophy. (author)

  6. Computerized radiation treatment planning

    International Nuclear Information System (INIS)

    Laarse, R. van der.

    1981-01-01

    Following a general introduction, a chain consisting of three computer programs which has been developed for treatment planning of external beam radiotherapy without manual intervention is described. New score functions used for determination of optimal incidence directions are presented and the calculation of the position of the isocentre for each optimum combination of incidence directions is explained. A description of how a set of applicators, covering fields with dimensions of 4 to 20 cm, for the 6 to 20 MeV electron beams of a MEL SL75-20 linear accelerator was developed, is given. A computer program for three dimensional electron beam treatment planning is presented. A microprocessor based treatment planning system for the Selectron remote controlled afterloading system for intracavitary radiotherapy is described. The main differences in treatment planning procedures for external beam therapy with neutrons instead of photons is discussed. A microprocessor based densitometer for plotting isodensity lines in film dosimetry is described. A computer program for dose planning of brachytherapy is presented. Finally a general discussion about the different aspects of computerized treatment planning as presented in this thesis is given. (Auth.)

  7. Radioactive waste computerized management

    International Nuclear Information System (INIS)

    Communaux, M.; Lantes, B.

    1993-01-01

    Since December 31, 1990, the management of the nuclear wastes for all the power stations has been computerized, using the DRA module of the Power Generation and Transmission Group's data processing master plan. So now EDF has a software package which centralizes all the data, enabling it to declare the characteristics of the nuclear wastes which are to be stored on the sites operated by the National Radioactive Waste Management Agency (ANDRA). Among other uses, this application makes it possible for EDF, by real time data exchange with ANDRA, to constitute an inventory of validated, shippable packs. It also constitutes a data base for all the wastes produced on the various sites. This application was developed to meet the following requirements: give the producers of radioactive waste a means to fully manage all the characteristics and materials that are necessary to condition their waste correctly; guarantee the traceability and safety of data and automatically assure the transmission of this data in real time between the producers and the ANDRA; give the Central Services of EDF an operation and statistical tool permitting an experienced feed-back based on the complete national production (single, centralized data base); and integrate the application within the products of the processing master plan in order to assure its maintenance and evolution

  8. Suppurative dacroadenitis causing ocular sicca syndrome in classic Wegener′s granulomatosis

    Directory of Open Access Journals (Sweden)

    Khanna Dhanita

    2011-01-01

    Full Text Available Wegener′s granulomatosis (WG is a multisystem vasculitic disorder which can commonly afflict various components of the eye. Here we describe some unusual ocular manifestations of the disease in one patient. A young male with history of upper respiratory tract symptoms including epistaxis, nasal stuffiness and maxillary sinus pain presented with bilateral lacrimal gland abscess and ptosis. Lacrimal gland biopsy revealed granulomatous vasculitis. Lung cavities, positive cytoplasmic-antineutrophil cytoplasmic antibodies and high titers of serine proteinase-3 antibodies confirmed the diagnosis of WG. The patient developed dry eyes after a month of first presentation. There was no dryness of mouth, suggesting the absence of salivary gland involvement, and antinuclear antibodies as well as antibodies against Ro and La antigens classical of primary Sjogren′s syndrome were absent. Granulomatous vasculitis of lacrimal gland leading to abscess formation and dryness of eyes has not been described in WG and reflects the aggressive nature of inflammatory process in this disease.

  9. Cutaneous granulomatosis and combined immunodeficiency revealing Ataxia-Telangiectasia: a case report

    Directory of Open Access Journals (Sweden)

    Antoccia Antonio

    2010-04-01

    Full Text Available Abstract Ataxia-telangiectasia (A-T is a complex multisystem disorder characterized by progressive neurological impairment, variable immunodeficiency and oculo-cutaneous telangiectasia. A-T is a member of chromosomal breakage syndromes and it is caused by a mutation in the ataxia-telangiectasia mutated (ATM gene. Because of a wide clinical heterogeneity, A-T is often difficult to diagnose in children. We report an unusual case of a 3-year-old boy affected by A-T who presented exclusively with extensive cutaneous granulomatosis and severe combined immunodeficiency, without neurological abnormalities, at the time of diagnosis. This case clearly emphasizes the variable presentation of A-T syndrome and highlights the difficulties in the early diagnosis of A-T. A-T should be considered in children with evidence of combined humoral and cellular immunodeficiency associated with unexplained skin granulomatous lesions, even in the absence of the classic features of this syndrome.

  10. Sequential rituximab and omalizumab for the treatment of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome).

    Science.gov (United States)

    Aguirre-Valencia, David; Posso-Osorio, Iván; Bravo, Juan-Carlos; Bonilla-Abadía, Fabio; Tobón, Gabriel J; Cañas, Carlos A

    2017-09-01

    Eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Churg-Strauss syndrome (CSS), is a small vessel vasculitis associated with eosinophilia and asthma. Clinical manifestations commonly seen in patients presenting with EGPA range from upper airway and lung involvement to neurological, cardiac, cutaneous, and renal manifestations. Treatment for severe presentations includes steroids, cyclophosphamide, plasmapheresis, and recently, rituximab. Rituximab is associated with a good response in the treatment of vasculitis, but a variable response for the control of allergic symptoms. Here, we report a 16-year-old female patient with severe EGPA (gastrointestinal and cutaneous vasculitis, rhinitis and asthma) refractory to conventional treatment. She was treated with rituximab, which enabled rapid control of the vasculitis component of the disease, but there was no response to rhinitis and asthma. Additionally, she developed severe bronchospasm during rituximab infusion. Sequential rituximab and omalizumab were initiated, leading to remission of all manifestations of vasculitis, rhinitis, and asthma, in addition to bronchospasm related to rituximab infusion.

  11. Granulomatosis de células de Langerhans: Presentación de un caso

    Directory of Open Access Journals (Sweden)

    . Caridad Nazco Ríos

    1998-12-01

    Full Text Available Se reporta un inusual caso de granulomatosis de células de Langerhans localizado en maxilares en un paciente de 30 meses de edad, quien presentaba además de las lesiones líticas óseas, lesiones de aspecto tumoral en encía palatina y lingual de ambas arcadas dentarias. El examen óseo no arrojaba compromiso de otros huesos. El diagnóstico histológico fue corroborado por el Centro Nacional de Referencia en Anatomía Patológica.A unusual case of Langerhans´ cells is reported, located in maxillae of a 30 months old patients, who, apart from bone lithic injuries, showed injuries of tumoral type in lingual and palatine gingiva of both dental archs. According to bone examination, there weren´t involvement of other bones. Histologic diagnosis was corroborated by National Reference Center in Pathologic Anatomy.

  12. Computerized data treatment technology

    International Nuclear Information System (INIS)

    Ferguson, R.B.; Maddox, J.H.; Wren, H.F.

    1977-01-01

    The Savannah River Laboratory (SRL) has accepted responsibility for a hydrogeochemical and stream-sediment reconnaissance in 25 eastern states as part of the National Uranium Resource Evaluation (NURE). SRL has developed a computerized program for recording, processing, updating, retrieving, and analyzing hydrogeochemical data from this reconnaissance. This program will handle an expected 150 million bytes of hydrogeochemical data from 150,000 to 200,000 sample sites over the next four years. The SRL--NURE hydrogeochemical data management system is written in FORTRAN IV for an IBM System 360/195 computer and is designed to easily accommodate changes in types of collected data and input format. As the data become available, they are accepted and combined with relevant data already in the system. SRL also developed a sample inventory and control system and a graphics and analysis system. The sample inventory and control system accounts for the movements of all samples and forms from initial receipt through final storage. Approximately six million sample movements are expected. The graphics and analysis system provides easily usable programs for reporting and interpreting data. Because of the large volume of data to be interpreted, the graphics and analysis system plays a central role in the hydrogeochemical program. Programs developed to provide two- and three-dimensional plots of sampled geographic areas show concentrations and locations of individual variables which are displayed and reproduced photographically. Pattern recognition techniques are also available, and they allow multivariate data to be categorized into ''clusters,'' which may indicate sites favorable for uranium exploration

  13. Altered Liver Proteoglycan/Glycosaminoglycan Structure as a Manifestation of Extracellular Matrix Remodeling upon BCG-induced Granulomatosis in Mice.

    Science.gov (United States)

    Kim, L B; Shkurupy, V A; Putyatina, A N

    2017-01-01

    Experimental BCG-induced granulomatosis in mice was used to study changes in the dynamics of individual liver proteoglycan components reflecting phasic extracellular matrix remodeling, determined by the host-parasite interaction and associated with granuloma development. In the early BCG-granulomatosis period, the increase in individual proteoglycan components promotes granuloma formation, providing conditions for mycobacteria adhesion to host cells, migration of phagocytic cells from circulation, and cell-cell interaction leading to granuloma development and fibrosis. Later, reduced reserve capacity of the extracellular matrix, development of interstitial fibrosis and granuloma fibrosis can lead to trophic shortage for cells within the granulomas, migration of macrophages out of them, and development of spontaneous necrosis and apoptosis typical of tuberculosis.

  14. Genetically distinct subsets within ANCA-associated vasculitis

    DEFF Research Database (Denmark)

    Lyons, Paul A; Rayner, Tim F; Trivedi, Sapna

    2012-01-01

    Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause is unknown, and there is debate about whether it is a single...

  15. Journey of Patients With Vasculitis From First Symptom to Diagnosis

    Science.gov (United States)

    2018-01-18

    Vasculitis; Systemic Vasculitis; Behcet's Disease; CNS Vasculitis; Cryoglobulinemic Vasculitis; Eosinophilic Granulomatous Vasculitis; Temporal Arteritis; Giant Cell Arteritis; Granulomatosis With Polyangiitis; Wegener Granulomatosis; Henoch Schonlein Purpura; IgA Vasculitis; Microscopic Polyangiitis; Polyarteritis Nodosa; Takayasu Arteritis; Urticarial Vasculitis

  16. Early Outcomes in Children With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

    DEFF Research Database (Denmark)

    Morishita, Kimberly A; Moorthy, Lakshmi N; Lubieniecka, Joanna M

    2017-01-01

    diagnosed before their eighteenth birthday as having granulomatosis with polyangiitis (Wegener's), microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss), or ANCA-positive pauci-immune glomerulonephritis. The primary outcome measure was achievement of disease remission...

  17. VCRC Tissue Repository

    Science.gov (United States)

    2018-04-23

    Aortitis; Cutaneous Vasculitis; Eosinophilic Granulomatosis With Polyangiitis; Giant Cell Arteritis; Granulomatosis With Polyangiitis (Wegener's); Henoch-Schonlein Purpura; IgA Vasculitis; Microscopic Polyangiitis; Polyarteritis Nodosa; Takayasu Arteritis; Churg-Strauss Syndrome

  18. Contrast-enhanced ultrasound and computed tomography findings of granulomatosis with polyangiitis presenting with multiple intrarenal microaneurysms: A case report.

    Science.gov (United States)

    Kim, Youe Ree; Lee, Young Hwan; Lee, Jong-Ho; Yoon, Kwon-Ha

    Granulomatosis with polyangiitis (GPA) is a systemic disorder that affects small- and medium- sized vessels in many organs. Although the kidneys are the second most commonly involved organ in patients with GPA, its manifestation as multiple intrarenal aneurysms is rare. We report an unusual manifestation of GPA with multiple intrarenal microaneurysms, as demonstrated by contrast-enhanced ultrasound and computed tomography. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Educational Needs of Patients With Systemic Vasculitis

    Science.gov (United States)

    2014-07-11

    Behcet's Disease; Churg-Strauss Syndrome; Vasculitis, Central Nervous System; Giant Cell Arteritis; Wegener Granulomatosis; Henoch-Schoenlein Purpura; Microscopic Polyangiitis; Polyarteritis Nodosa; Takayasu's Arteritis

  20. Case report

    African Journals Online (AJOL)

    iamong

    2016-08-11

    pulmonary capillaritis, bland pulmonary hemorrhage and diffuse alveolar damage) [3]. Generally, the pulmonary alveolar hemorrhage is caused by Wegener's granulomatosis, microscopic polyangitis, antiphospholipid antibody ...

  1. Technologies in computerized lexicography | Kruyt | Lexikos

    African Journals Online (AJOL)

    Although the topic of this paper is technology, focus is on functional rather than technical aspects of computerized lexicography. Keywords: computerized lexicography, electronic dictionary, electronic text corpus, lexicographer's workbench, integrated language database, automatic linguistic analysis, information retrieval, ...

  2. Effects of Wegener-Bergeron-Findeisen Process on Global Black Carbon Distribution

    Science.gov (United States)

    Qi, L.

    2016-12-01

    In mixed-phase clouds, the Wegener-Bergeron-Findeisen (WBF) process (ice crystals may grow while water drops evaporate, thereby releasing black carbon (BC) particles into the interstitial air) slows down wet scavenging of BC. Rimming (snowflakes fall and collect cloud water drops and the BC in them along their pathways), in contrast, results in more efficient wet scavenging. We systematically investigate the effects of WBF on BC scavenging efficiency, surface BCair, deposition flux, concentration in snow, and washout ratio using a global 3D chemical transport model. We differentiate riming- vs WBF-dominated in-cloud scavenging based on liquid water content and temperature. Specifically, we relate WBF to either temperature or ice mass fraction in mixed-phase clouds. We find that at Jungfraujoch, Switzerland and Abisko, Sweden, where WBF dominates, the discrepancies of simulated BC scavenging efficiency and washout ratio are significantly reduced (from a factor of 3 to 10% and from a factor of 4-5 to a factor of two). However, at Zeppelin, Norway, where riming dominates, simulation of BC scavenging efficiency, BCair, and washout ratio become worse (relative to observations) when WBF is included. There is thus an urgent need for extensive observations to distinguish and characterize riming- versus WBF-dominated aerosol scavenging in mixed-phase clouds and the associated BC scavenging efficiency. We find the reduction resulting from WBF to global BC scavenging efficiency varies substantially, from 8% in the tropics to 76% in the Arctic. The resulting annual mean BCair increases by up to 156% at high altitudes and at northern high latitudes. Overall, WBF halves the model-observation discrepancy (from -65% to -30%) of BCair across North America, Europe, China and the Arctic. Globally WBF increases BC burden from 0.22 to 0.29-0.35 mg m-2 yr-1, which partially explains the gap between observed and previous model simulated BC burdens over land (Bond et al., 2013). In

  3. Effect of Wegener-Bergeron-Findeisen Process to Black Carbon Simulation

    Science.gov (United States)

    Qi, Ling; Li, Qinbin; He, Cenlin; Wang, Xin; Huang, Jianping

    2016-04-01

    We systematically investigated the effect of Wegener-Bergeron-Findeisen (WBF) process to black carbon (BC) simulation by a global 3D chemical transport model GEOS-Chem constrained by measurements of BC scavenging efficiencies, concentration in air, deposition fluxes, concentration in snow and washout ratios. Including effect of WBF process reduces the annual mean BC scavenging efficiencies (the ratio of BC in cloud droplets to total BC) at all altitudes by 43-76% in the Arctic. For mid latitude BC scavenging efficiencies decrease by 8-22%, 23-39%, and 41-50% in lower (0-2 km), middle (2-5 km) and upper troposphere (5-10 km), respectively. Simulated BC in air in the Arctic and at mid altitude (˜4 km) in mid latitude increases by ˜40%, and the discrepancy reduces from -65% to -30%. Simulated median BC in snow decreases from 25.7 to 22.4 ng g-1, by 15% in mid latitude and increases from 8.7 to 11.0 ng g-1, by 26% in the Arctic and the comparison with observations improves. The model overestimates washout ratios (ratio of BC in fresh snow/rain to BC in surface air) at most of the sites by up to a factor of 165. With effect of WBF process included, the discrepancy decreases to a factor of 72. The simulated BC burden increases from 0.22 to 0.35 mg m-2 yr-1 when effect of WBF process is included, partly explains the scaled up of BC burden in Bond et al., 2013. Moreover, burden above 5 km increases from 22% to 27% when WBF process is included, indicating a higher forcing efficiency. We also found that BC simulation is insensitive to the temperature criteria between mixed phase clouds and ice clouds. The simulated BC burden is the same when the temperature is set as -15° C and -25° C. This study also suggests that more observations are needed to better distinguish riming dominated and WBF dominated conditions and better parameterize BC scavenging efficiency under the two conditions.

  4. Rituximab in the treatment of refractory or relapsing eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome).

    Science.gov (United States)

    Thiel, Jens; Hässler, Fabian; Salzer, Ulrich; Voll, Reinhard E; Venhoff, Nils

    2013-09-24

    Eosinophilic granulomatosis with polyangiitis (EGPA) is part of antineutrophil cytoplasmic antibodies (ANCAs)-associated vasculitides. In EGPA small-vessel vasculitis is associated with eosinophilia and asthma. About 40% of EGPA patients are ANCA-positive, suggesting a role for B cells in the pathogenesis of EGPA. B cell-depleting therapy with rituximab (RTX) can be effective in ANCA-positive EGPA, but very few patients have been published to date. The role of RTX in the treatment of ANCA-negative EGPA is unclear. We report a single-center cohort of patients with eosinophilic granulomatosis with polyangiitis. Of these patients, nine (six ANCA-positive, three ANCA-negative) had been treated with RTX for relapsing or refractory disease on standard immunosuppressive treatment. In a retrospective analysis, data on treatment response, frequency of relapses, adverse events, and peripheral B-cell reconstitution were evaluated. Furthermore, serum immunoglobulin concentrations, ANCA status, and peripheral B cell subpopulations were assessed after RTX treatment. All patients had high disease activity before RTX treatment. At presentation 3 months after RTX therapy, all ANCA-positive and ANCA-negative patients had responded to RTX, with one patient being in complete remission, and eight patients being in partial remission. After a mean follow-up of 9 months, C-reactive protein concentrations had normalized, eosinophils had significantly decreased, and prednisone had been tapered in all patients. In all patients, RTX therapy was combined with a standard immunosuppressive therapy. Within the 9-month observation period, no relapse was recorded. Three patients were preemptively retreated with RTX, and during the median follow-up time of 3 years, no relapse occurred in these patients. During the follow-up of 13 patient-years, five minor but no major infections were recorded. In our analysis on nine patients with EGPA resistant to standard therapy, rituximab proved to be an

  5. Computerized Proof Techniques for Undergraduates

    Science.gov (United States)

    Smith, Christopher J.; Tefera, Akalu; Zeleke, Aklilu

    2012-01-01

    The use of computer algebra systems such as Maple and Mathematica is becoming increasingly important and widespread in mathematics learning, teaching and research. In this article, we present computerized proof techniques of Gosper, Wilf-Zeilberger and Zeilberger that can be used for enhancing the teaching and learning of topics in discrete…

  6. Computerized adaptive testing in computer assisted learning?

    NARCIS (Netherlands)

    Veldkamp, Bernard P.; Matteucci, Mariagiulia; Eggen, Theodorus Johannes Hendrikus Maria; De Wannemacker, Stefan; Clarebout, Geraldine; De Causmaecker, Patrick

    2011-01-01

    A major goal in computerized learning systems is to optimize learning, while in computerized adaptive tests (CAT) efficient measurement of the proficiency of students is the main focus. There seems to be a common interest to integrate computerized adaptive item selection in learning systems and

  7. Purpura, petechiae, and bullae as first signs of juvenile granulomatosis with polyangiitis.

    Science.gov (United States)

    Rawn, Saara; Miettunen, Paivi; Brown, Holly A; Schmeling, Heinrike

    2014-12-01

    We present a case of a 14-year-old girl who had a severe form of granulomatosis with polyangiitis (GPA) with extensive dermatological involvement, whose initial presentation was nonspecific leading to diagnostic confusion and initial consideration of infectious and other vasculitis causes. The patient presented with fever, congestion, malaise, and sinus pain. She was diagnosed with bacterial sinusitis and treated with antibiotics. Within weeks, she developed abdominal pain, hematuria, migratory arthritis, and palpable purpura and was diagnosed with Henoch-Schonlein purpura. She went on to develop hemoptysis and progression of the rash into erosive bullae. Investigations revealed that she was ANCA positive and had pauci-immune glomerulonephritis. Given her upper airway, pulmonary and renal involvement, and antineutrophil cytoplasmic antibodies positivity, a definitive diagnosis of a severe form of GPA was made. GPA is a chronic relapsing, life threatening vasculitis that predominantly affects small vessels. Our case demonstrates that GPA can present initially with nonspecific symptoms, including extensive dermatological involvement, leading to diagnostic confusion, and delays in treatment. In the case of a severe peripheral rash in the juvenile population and/or resistant upper airway symptoms, it is vital to consider a diagnosis of GPA to avoid serious organ or life threatening consequences.

  8. A case of exorbitism in association with Wegener′s granulomatosis with renal involvement

    Directory of Open Access Journals (Sweden)

    S Beji

    2012-01-01

    Full Text Available Wegener′s granulomatosis (WG is a necrotizing granulomatous vasculitis invol-ving the nose, paranasal sinuses, lungs, and kidneys. Ocular involvement can occur in about 50% of cases. There are very few reports of WG with orbital inflammation and exorbitism. We report a case of a female patient who presented with exorbitism related to orbital inflammation secondary to WG, with renal involvement. A 29-year-old woman with a previous history of recurrent pan-sinusitis presented with bilateral exophthalmos and renal failure with rapidly progressive glo-merulonephritis. Computed tomography showed extensive bilateral soft tissue in the retro-orbital area. Immunologic tests showed the presence of type-C anti-neutrophil cytoplasmic antibodies and renal biopsy revealed pauci immune crescentic glomerulonephritis. The patient was treated with corticosteroids and pulses of cyclophosphamide followed by azathioprine and trimethoprim-sulfamethoxazole. After a follow-up of 10 months, the renal outcome was favorable with improvement of renal function but there was persistence of exorbitism and loss of visual function. Our case suggests that WG should be considered in the differential diagnosis of persistent bila-teral exophthalmos. Prompt recognition of this early manifestation is important for the institution of early treatment.

  9. Omalizumab in patients with eosinophilic granulomatosis with polyangiitis: a 36-month follow-up study.

    Science.gov (United States)

    Detoraki, Aikaterini; Di Capua, Lorena; Varricchi, Gilda; Genovese, Arturo; Marone, Gianni; Spadaro, Giuseppe

    2016-01-01

    Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis characterized by asthma and blood eosinophilia, with the lung being the organ most frequently affected. Oral glucocorticoids and/or immunosuppressive drugs are the mainstay therapy of EGPA. Occasional reports suggest that EGPA patients can be treated with omalizumab in addition to conventional therapy to achieve asthma control. To investigate the long-term effects of omalizumab in patients with EGPA and asthma (2 females, 3 males, age 41-64 years), we carried out a 36-month follow-up observational study. At the time of enrollment, the patients were on maintenance therapy and had moderate to severe allergic asthma, eosinophilia and rhinosinusitis. Mononeuropathy/polyneuropathy and/or histological evidence of tissue eosinophilic infiltration were also present. Patients were treated with omalizumab (300-600 mg s.c. every 2-4 weeks) as add-on therapy to prednisone, inhaled steroids and bronchodilators. During omalizumab treatment, spirometry, the asthma control test (ACT) score and eosinophilia were evaluated, and prednisone dosage was recorded. During the 36 months of omalizumab treatment asthma progressively improved as indicated by spirometry and the ACT score. Eosinophilia progressively decreased. The oral prednisone dose was reduced or withdrawn during treatment. No adverse events were recorded. In patients with EGPA and moderate to severe allergic asthma, omalizumab can be beneficial and safe. It enables corticosteroid tapering while decreasing eosinophilia and improving asthma symptoms over 36 months.

  10. Heart transplantation in patients with eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome).

    Science.gov (United States)

    Groh, Matthieu; Masciocco, Gabriella; Kirchner, Elizabeth; Kristen, Arnt; Pellegrini, Carlo; Varnous, Shaïda; Bortman, Guillermo; Rosenberg, Mark; Brucato, Antonio; Waterworth, Paul; Bonacina, Edgardo; Facchetti, Fabio; Calabrese, Leonard; Gregorini, Gina; Scali, Juan Jose; Starling, Randall; Frigerio, Maria; D'Armini, Andrea Maria; Guillevin, Loïc

    2014-08-01

    Heart involvement is the leading cause of death of patients with eosinophilic granulomatosis with polyangiitis (EGPA; formerly Churg-Strauss syndrome) and is more frequent in anti-neutrophil cytoplasm antibody (ANCA)-negative patients. Post-transplant outcome has only been reported once. We conducted a retrospective international multicenter study. Patients satisfying the criteria of the American College of Rheumatology and/or revised Chapel Hill Consensus Conference Nomenclature were identified by collaborating vasculitis and transplant specialists, and the help of the Churg-Strauss Syndrome Association. Nine ANCA(-) patients who received transplants between October 1987 and December 2009 were identified. The vasculitis and cardiomyopathy diagnoses were concomitant for 5 patients and separated by 12 to 288 months for the remaining 4 patients. Despite ongoing immunosuppression, histologic examination of 7 (78%) patients' explanted hearts showed histologic patterns suggestive of active vasculitis. The overall 5-year survival rate was low (57%), but rose to 80% when considering only the 6 patients transplanted during the last decade. After survival lasting 3 to 60 months, 4 (44%) patients died sudden deaths. The search for EGPA-related cardiomyopathy is mandatory early in the course of this type of vasculitis. Indeed, prompt treatment with corticosteroids and cyclophosphamide may achieve restore cardiac function. Most patients in this series were undertreated. For patients with refractory EGPA, heart transplantation should be performed, which carries a fair prognosis. No optimal immunosuppressive strategy has yet been identified. Copyright © 2014 International Society for Heart and Lung Transplantation. All rights reserved.

  11. Optimal therapy and prospects for new medicines in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome).

    Science.gov (United States)

    Pagnoux, Christian; Groh, Matthieu

    2016-10-01

    The prevalence of eosinophilic granulomatosis with polyangiitis (EGPA; previously known as Churg-Strauss syndrome) is lower than that of other antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV's), and only a few randomized controlled trials have been conducted for this rare disease. However, recent international efforts have helped delineate the best treatment approach. At present, EGPA conventional therapy is by default similar to that of other AAVs. Limited, non-severe EGPA can initially be treated with glucocorticoids (GCs) alone. Patients with life-threatening manifestations and/or major organ involvement must receive a combination of GCs and an immunosuppressant, mainly cyclophosphamide. Remission can be achieved in >85% of patients with these first-line treatments, but vasculitis relapses occur in more than one-third of patients, and about 85% cannot stop GC treatment because of GC-dependent asthma and/or ENT manifestations. A few biologic agents, including rituximab or mepolizumab, are now under investigation after interesting preliminary results. Expert commentary: Treatment for EGPA still has several unmet needs. Several biologic agents are now under investigation in randomized controlled trials, but a few others should be considered soon. Their benefit should be demonstrated for devising more EGPA-tailored therapeutic strategies (ideally GC-free).

  12. Efficiency of using rituximab in a patient with generalized granulomatosis with polyangiitis: A case report

    Directory of Open Access Journals (Sweden)

    Gulazyk Malikovna Koilubaeva

    2014-01-01

    Full Text Available Systemic vasculitides (SVs are characterized by inflammation of the blood vessels wall; the spectrum of their clinical manifestations depends on the type, extent, and location of affected vessels and the activity of systemic inflammation. The etiology of most primary SVs is unknown. Antineutrophil cytoplasmic antibodies (ANCAs are implicated in its pathogenesis. The presence of ANCAa in patients' serum and the correlation of their level with the severity of clinical manifestations served as a basis for identifying a subgroup of systemic necrotizing vasculitides associated with ANCA synthesis: granulomatosis with polyangiitis (GPA, microscopic polyangiitis, and Churg – Strauss syndrome. GPA is characterized by systemic granulomatous necrotizing vasculitis involving the small vessels of the upper respiratory tract, lung, and kidney.The paper describes a case of difficult diagnosis and successful rituximab (RTM treatment of generalized GPA in a 45-year-old female patients. The disease occurred with local damage to the upper respiratory tract, granulomatous inflammation of the pulmonary vessels to form multiple infiltrates with lung tissue destruction elements and necrotizing glomerulonephritis. Despite intensive immunosuppressive treatment, there was a rapid GPA progression with the further development of respiratory failure, which had been induced by stenotic laryngitis subglottica leading to tracheostoma. Damage to the organ of vision could lead to severe complications, including amaurosis. RMT was shown to be effective in treating generalized GPA with a poor prognosis.

  13. Serum biomarkers in patients with relapsing eosinophilic granulomatosis with polyangiitis (Churg-Strauss.

    Directory of Open Access Journals (Sweden)

    Christian Dejaco

    Full Text Available Previous studies suggest a role for eotaxin-3, TARC/CCL17 and IgG4 in newly-diagnosed patients with eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss with highly active disease. The role of these biomarkers in relapsing disease is unclear.Serum levels of TARC/CCL17, eotaxin-3, IgG4, and IgG4/IgG ratio were determined in serum samples from a longitudinal cohort of patients with EGPA (105 visits of 25 patients. Epidemiological, clinical and laboratory data were available for all visits.At the first visit, 80% of patients were using glucocorticoids and 68% additional immunosuppressive drugs. Disease flares were seen at 18 visits. The median BVAS and BVAS/WG scores at time of relapse were 4 and 2, respectively. None of the biomarkers tested were useful to discriminate between active disease and remission. Patients treated with prednisone had lower eotaxin-3 and eosinophil levels compared to patients not taking glucocorticoids irrespective of disease activity. Use of immunosuppressive agents was not associated with biomarker levels.Serum levels of TARC/CCL17, eotaxin-3, IgG4, and IgG4/IgG ratio do not clearly differentiate active and inactive disease in established EGPA. Defining biomarkers in EGPA remains a challenge especially during times of glucocorticoid use.

  14. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome and pulmonary thromboembolism: an overlooked concomitance

    Directory of Open Access Journals (Sweden)

    Vilma Takayasu

    2013-06-01

    Full Text Available The Eosinophilic Granulomatosis with Polyangiitis (formerly Churg- Strauss Syndrome (EGPA is a systemic inflammatory disease characterized by the presence of rhinitis, asthma, peripheral eosinophilia, and vasculitis—the latter being characteristic of the late stage of the disease. After several years from the onset of the disease, small- and medium-sized vessel vasculitis ensues, undertaking various organs and systems. Upper and lower airways, skin, nervous system, gastrointestinal tract, heart, and kidneys are the most commonly involved organs. It is believed that tissue injury is the result of processes mediated by antineutrophil cytoplasmic antibody (ANCA, or toxic mediators released by eosinophils. Although it is classified as ANCA-associated vasculitis, these autoantibodies are present in only 40% of cases. The authors report the case of a patient with EGPA, who had a history of asthma, peripheral and central neuropathy, palpable purpura, gastrointestinal micro perforation, peripheral eosinophilia, and the presence of myeloperoxidase-antineutrophil cytoplasmic antibody. Inflammatory parameters improved after the initiation of treatment, but 1 month after hospital discharge the patient developed symptoms compatible with pulmonary embolism and died. Thrombophilia that occurs in EGPA is due to the interaction between the inflammatory response and eosinophilia with the clotting system resulting in a pro-thrombotic state. Although not yet well-determined, the authors call attention to the possibility of the impact of thromboembolic events on the prognosis of patients with EGPA. In addition to the adequate immunosuppressive treatment, prophylaxis and treatment for thrombosis should never be overlooked.

  15. Granulomatosis with Polyangiitis Presenting as Pauci-Immune Crescentic Glomerulonephritis in Pregnancy

    Directory of Open Access Journals (Sweden)

    Ryan Kunjal

    2016-01-01

    Full Text Available Antineutrophil cytoplasmic antibody (ANCA associated vasculitis rarely affects females of reproductive age. A 28-year-old African American woman presented at 8 weeks of gestation with intractable vomiting attributed to hyperemesis gravidarum. She was found to have acute kidney injury that was unresponsive to vigorous fluid resuscitation and urine sediment examination was suggestive of an underlying glomerulonephritis. Serum c-ANCA and PR3 were elevated and there was no peripheral eosinophilia. During her course she also developed one episode of small volume hemoptysis with right upper lobe infiltrates on CT Chest. There were no cutaneous manifestations of vasculitis or upper respiratory symptoms. Renal biopsy revealed a pauci-immune crescentic glomerulonephritis (PICGN. The diagnosis was consistent with granulomatosis with polyangiitis (GPA. Management initially comprised teratogen sparing agents; steroids, intravenous immunoglobulin; and plasma exchange. The response was suboptimal and she became dependent on daily renal replacement therapy. Ultimately the pregnancy was terminated allowing for traditional treatment approaches with dramatic effect. This is the first case of GPA presenting as PICGN in pregnancy and highlights the challenges of its management.

  16. Granulomatosis with Polyangiitis Presenting as Pauci-Immune Crescentic Glomerulonephritis in Pregnancy.

    Science.gov (United States)

    Kunjal, Ryan; Makary, Raafat; Poenariu, Andreea

    2016-01-01

    Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis rarely affects females of reproductive age. A 28-year-old African American woman presented at 8 weeks of gestation with intractable vomiting attributed to hyperemesis gravidarum. She was found to have acute kidney injury that was unresponsive to vigorous fluid resuscitation and urine sediment examination was suggestive of an underlying glomerulonephritis. Serum c-ANCA and PR3 were elevated and there was no peripheral eosinophilia. During her course she also developed one episode of small volume hemoptysis with right upper lobe infiltrates on CT Chest. There were no cutaneous manifestations of vasculitis or upper respiratory symptoms. Renal biopsy revealed a pauci-immune crescentic glomerulonephritis (PICGN). The diagnosis was consistent with granulomatosis with polyangiitis (GPA). Management initially comprised teratogen sparing agents; steroids, intravenous immunoglobulin; and plasma exchange. The response was suboptimal and she became dependent on daily renal replacement therapy. Ultimately the pregnancy was terminated allowing for traditional treatment approaches with dramatic effect. This is the first case of GPA presenting as PICGN in pregnancy and highlights the challenges of its management.

  17. First results from comparison of rainfall estimations by GPM IMERG with rainfall measurements from the WegenerNet high density network

    Science.gov (United States)

    Oo, Sungmin; Foelsche, Ulrich; Kirchengast, Gottfried; Fuchsberger, Jürgen

    2016-04-01

    The research level products of the Integrated Multi-Satellite Retrievals for Global Precipitation Measurement (IMERG "Final" run datasets) were compared with rainfall measurements from the WegenerNet high density network as part of ground validation (GV) projects of GPM missions. The WegenerNet network comprises 151 ground level weather stations in an area of 15 km × 20 km in south-eastern Austria (Feldbach region, ˜46.93° N, ˜15.90° E) designed to serve as a long-term monitoring and validation facility for weather and climate research and applications. While the IMERG provides rainfall estimations every half hour at 0.1° resolution, the WegenerNet network measures rainfall every 5 minutes at around 2 km2 resolution and produces 200 m × 200 m gridded datasets. The study was conducted on the domain of the WegenerNet network; eight IMERG grids are overlapped with the network, two of which are entirely covered by the WegenerNet (40 and 39 stations in each grid). We investigated data from April to September of the years 2014 to 2015; the date of first two years after the launch of the GPM Core Observatory. Since the network has a flexibility to work with various spatial and temporal scales, the comparison could be conducted on average-points to pixel basis at both sub-daily and daily timescales. This presentation will summarize the first results of the comparison and future plans to explore the characteristics of errors in the IMERG datasets.

  18. Effects of the Wegener-Bergeron-Findeisen process on global black carbon distribution

    Science.gov (United States)

    Qi, Ling; Li, Qinbin; He, Cenlin; Wang, Xin; Huang, Jianping

    2017-06-01

    We systematically investigate the effects of Wegener-Bergeron-Findeisen process (hereafter WBF) on black carbon (BC) scavenging efficiency, surface BCair, deposition flux, concentration in snow (BCsnow, ng g-1), and washout ratio using a global 3-D chemical transport model (GEOS-Chem). We differentiate riming- versus WBF-dominated in-cloud scavenging based on liquid water content (LWC) and temperature. Specifically, we implement an implied WBF parameterization using either temperature or ice mass fraction (IMF) in mixed-phase clouds based on field measurements. We find that at Jungfraujoch, Switzerland, and Abisko, Sweden, where WBF dominates in-cloud scavenging, including the WBF effect strongly reduces the discrepancies of simulated BC scavenging efficiency and washout ratio against observations (from a factor of 3 to 10 % and from a factor of 4-5 to a factor of 2). However, at Zeppelin, Norway, where riming dominates, simulation of BC scavenging efficiency, BCair, and washout ratio become worse (relative to observations) when WBF is included. There is thus an urgent need for extensive observations to distinguish and characterize riming- versus WBF-dominated aerosol scavenging in mixed-phase clouds and the associated BC scavenging efficiency. Our model results show that including the WBF effect lowers global BC scavenging efficiency, with a higher reduction at higher latitudes (8 % in the tropics and up to 76 % in the Arctic). The resulting annual mean BCair increases by up to 156 % at high altitudes and at northern high latitudes because of lower temperature and higher IMF. Overall, WBF halves the model-observation discrepancy (from -65 to -30 %) of BCair across North America, Europe, China and the Arctic. Globally WBF increases BC burden from 0.22 to 0.29-0.35 mg m-2 yr-1, which partially explains the gap between observed and previous model-simulated BC burdens over land. In addition, WBF significantly increases BC lifetime from 5.7 to ˜ 8 days. Additionally

  19. Computerized ECT data analysis system

    International Nuclear Information System (INIS)

    Miyake, Y.; Fukui, S.; Iwahashi, Y.; Matsumoto, M.; Koyama, K.

    1988-01-01

    For the analytical method of the eddy current testing (ECT) of steam generator tubes in nuclear power plants, the authors have developed the computerized ECT data analysis system using a large-scale computer with a high-resolution color graphic display. This system can store acquired ECT data up to 15 steam generators, and ECT data can be analyzed immediately on the monitor in dialogue communication with a computer. Analyzed results of ECT data are stored and registered in the data base. This system enables an analyst to perform sorting and collecting of data under various conditions and obtain the results automatically, and also to make a plan of tube repair works. This system has completed the test run, and has been used for data analysis at the annual inspection of domestic plants. This paper describes an outline, features and examples of the computerized eddy current data analysis system for steam generator tubes in PWR nuclear power plants

  20. Quantitative inspection by computerized tomography

    International Nuclear Information System (INIS)

    Lopes, R.T.; Assis, J.T. de; Jesus, E.F.O. de

    1989-01-01

    The computerized Tomography (CT) is a method of nondestructive testing, that furnish quantitative information, that permit the detection and accurate localization of defects, internal dimension measurement, and, measurement and chart of the density distribution. The CT technology is much versatile, not presenting restriction in relation to form, size or composition of the object. A tomographic system, projected and constructed in our laboratory is presented. The applications and limitation of this system, illustrated by tomographyc images, are shown. (V.R.B.)

  1. Computerized accounting methods. Final report

    International Nuclear Information System (INIS)

    1994-01-01

    This report summarizes the results of the research performed under the Task Order on computerized accounting methods in a period from 03 August to 31 December 1994. Computerized nuclear material accounting methods are analyzed and evaluated. Selected methods are implemented in a hardware-software complex developed as a prototype of the local network-based CONMIT system. This complex has been put into trial operation for test and evaluation of the selected methods at two selected ''Kurchatov Institute'' Russian Research Center (''KI'' RRC) nuclear facilities. Trial operation is carried out since the beginning of Initial Physical Inventory Taking in these facilities that was performed in November 1994. Operation of CONMIT prototype system was demonstrated in the middle of December 1994. Results of evaluation of CONMIT prototype system features and functioning under real operating conditions are considered. Conclusions are formulated on the ways of further development of computerized nuclear material accounting methods. The most important conclusion is a need to strengthen computer and information security features supported by the operating environment. Security provisions as well as other LANL Client/Server System approaches being developed by Los Alamos National Laboratory are recommended for selection of software and hardware components to be integrated into production version of CONMIT system for KI RRC

  2. Eosinophilic granulomatosis with polyangiitis (formerly known as Churg-Strauss syndrome as a differential diagnosis of hypereosinophilic syndromes

    Directory of Open Access Journals (Sweden)

    Yuri Albuquerque Pessoa Santos

    2017-01-01

    Full Text Available Eosinophilic granulomatosis with polyangiitis (EGPA, formerly known as Churg-Strauss syndrome, is a rare systemic disease situated between primary small vessel vasculitides associated with antineutrophil cytoplasmic antibodies (ANCAs and hypereosinophilic syndromes (HES. Here, we present a case of EGPA in a 38-year-old male, with a previous diagnosis of asthma, who presented with fever, migratory lung infiltrates and systemic eosinophilia that was refractory to previous courses of antibiotics. This case highlights the importance of the primary care physician understanding the differential diagnosis of pulmonary eosinophilic syndromes.

  3. Diagnosis and classification of eosinophilic granulomatosis with polyangiitis (formerly named Churg-Strauss syndrome).

    Science.gov (United States)

    Mouthon, Luc; Dunogue, Bertrand; Guillevin, Loïc

    2014-01-01

    Recently, a group of experts in the field suggested to rename Churg-Strauss syndrome as eosinophilic granulomatosis with polyangiitis (EGPA). This condition, first described in 1951, is a rare small- and medium-sized-vessel vasculitis characterized by an almost constant association with asthma and eosinophilia, and, by the presence of anti-myeloperoxidase (MPO) antineutrophil cytoplasm antibodies (ANCA) in 30-38% of the patients. Vasculitis typically develops in a previously asthmatic and eosinophilic middle-aged patient. Asthma is severe, associated with eosinophilia and extrapulmonary symptoms. Most frequently EGPA involves the peripheral nerves and skin. Other organs, however, may be affected and must be screened for vasculitis, especially those associated with a poorer prognosis, such as the heart, kidney and gastrointestinal tract, as assessed by the recently revised Five-Factor Score (FFS). Recent insights, particularly concerning clinical differences associated with ANCA status, showed that EGPA patients might constitute a heterogeneous group. Thus, EGPA patients with anti-MPO ANCA suffered more, albeit not exclusively, from vasculitis symptoms, such as glomerulonephritis, mononeuritis multiplex and alveolar hemorrhage, whereas ANCA-negative patients more frequently develop heart involvement. This observation led to the hypothesis that EGPA might be divided into different clinical and pathophysiological subtypes, which could be managed better with more specifically adapted therapies. For now, EGPA treatment still relies mainly on corticosteroids and, when necessary for patients with poorer prognoses, combined immunosuppressant drugs, especially cyclophosphamide. Overall survival of EGPA patients is good, despite not uncommon relapses. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Computerized tomography of orbital lesions

    International Nuclear Information System (INIS)

    Kuroiwa, Mayumi

    1981-01-01

    Two different types of computerized tomography scanners (CT scanner), i.e. a whole-body CT scanner (GE-CT/T8800) and a cerebral CT scanner (EMI-1010), were compared in the assessment and diagnosis of various orbital lesions. The whole-body CT scanner was found to be advantageous over the cerebral CT scanner for the following reasons: (1) CT images were more informative due to thinner slices associated with smaller-sized and larger-numbered matrices; (2) less artifacts derived from motion of the head or eyeball were produced because of the shorter scanning time; (3) with a devised gantry, coronal dissections were available whenever demanded. (author)

  5. Genetically distinct subsets within ANCA-associated vasculitis.

    LENUS (Irish Health Repository)

    Lyons, Paul A

    2012-07-19

    Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener\\'s granulomatosis) and microscopic polyangiitis. Its cause is unknown, and there is debate about whether it is a single disease entity and what role ANCA plays in its pathogenesis. We investigated its genetic basis.

  6. DOE transporation programs - computerized techniques

    Energy Technology Data Exchange (ETDEWEB)

    Joy, D.S.; Johnson, P.E.; Fore, C.S.; Peterson, B.E.

    1983-01-01

    One of the major thrusts of the transportation programs at the Oak Ridge National Laboratory has been the development of a number of computerized transportation programs and data bases. The U.S. Department of Energy (DOE) is supporting these efforts through the Transportation Technology Center at Sandia National Laboratories and the Tranportation Operations and Traffic Management (TOTM) organization at DOE Headquarters. Initially this project was centered upon research activities. However, since these tools provide traffic managers and key personnel involved in preshipment planning with a unique resource for ensuring that the movement of radioactive materials can be properly accomplished, additional interest and support is coming from the operational side of DOE. The major accomplishments include the development of two routing models (one for rail shipments and the other for highway shipments), an emergency response assistance program, and two data bases containing pertinent legislative and regulatory information. This paper discusses the mose recent advances in, and additions to, these computerized techniques and provides examples of how they are used.

  7. Computerized index for teaching files

    International Nuclear Information System (INIS)

    Bramble, J.M.

    1989-01-01

    A computerized index can be used to retrieve cases from a teaching file that have radiographic findings similar to an unknown case. The probability that a user will review cases with a correct diagnosis was estimated with use of radiographic findings of arthritis in hand radiographs of 110 cases from a teaching file. The nearest-neighbor classification algorithm was used as a computer index to 110 cases of arthritis. Each case was treated as an unknown and inputted to the computer index. The accuracy of the computer index in retrieving cases with the same diagnosis (including rheumatoid arthritis, gout, psoriatic arthritis, inflammatory osteoarthritis, and pyrophosphate arthropathy) was measured. A Bayes classifier algorithm was also tested on the same database. Results are presented. The nearest-neighbor algorithm was 83%. By comparison, the estimated accuracy of the Bayes classifier algorithm was 78%. Conclusions: A computerized index to a teaching file based on the nearest-neighbor algorithm should allow the user to review cases with the correct diagnosis of an unknown case, by entering the findings of the unknown case

  8. Aortic {sup 18}F-FDG uptake in patients suffering from granulomatosis with polyangiitis

    Energy Technology Data Exchange (ETDEWEB)

    Kemna, Michael J. [Maastricht University Medical Center, Department of Nephrology and Clinical Immunology, Maastricht (Netherlands); Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), Maastricht (Netherlands); Bucerius, Jan [Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), Maastricht (Netherlands); Maastricht University Medical Center, Department of Nuclear Medicine, Maastricht (Netherlands); University Hospital RWTH Aachen, Department of Nuclear Medicine, Aachen (Germany); Drent, Marjolein [Maastricht University, Department of Pharmacology and Toxicology, Maastricht (Netherlands); Voeoe, Stefan [Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), Maastricht (Netherlands); Maastricht University Medical Center, Department of Nuclear Medicine, Maastricht (Netherlands); Veenman, Martine [Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), Maastricht (Netherlands); Paassen, Pieter van [Maastricht University Medical Center, Department of Nephrology and Clinical Immunology, Maastricht (Netherlands); Tervaert, Jan Willem Cohen [Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), Maastricht (Netherlands); Sint Franciscus Gasthuis, Noordoever Academy, Rotterdam (Netherlands); Kroonenburgh, Marinus J.P.G. van [Maastricht University Medical Center, Department of Nuclear Medicine, Maastricht (Netherlands)

    2015-08-15

    The objective of the study was to systematically assess aortic inflammation in patients with granulomatosis with polyangiitis (GPA) using {sup 18}F-2-deoxy-2-[{sup 18}F]fluoro-D-glucose (FDG) positron emission tomography (PET)/CT. Aortic inflammation was studied in PET/CT scans obtained from 21 patients with GPA; 14 patients with sarcoidosis were included as disease controls, 7 patients with stage I or II head and neck carcinoma ascertained during routine clinical practice were used as healthy controls (HC) and 5 patients with large vessel vasculitis (LVV) were used as positive controls. Aortic {sup 18}F-FDG uptake was expressed as the blood-normalized maximum standardized uptake value (SUV{sub max}), known as the target to background ratio (mean TBR{sub max}). The mean TBR{sub max} (interquartile range) of the aorta in patients with GPA, sarcoidosis, HC and LVV were 1.75 (1.32-2.05), 1.62 (1.54-1.74), 1.29 (1.22-1.52) and 2.03 (1.67-2.45), respectively. The mean TBR{sub max} was significantly higher in patients suffering from GPA or LVV compared to HC (p < 0.05 and p < 0.005, respectively) and tended to be higher in patients suffering from sarcoidosis, but this did not reach statistical significance (p = 0.098). The mean TBR{sub max} of the most diseased segment was significantly higher compared to HC [1.57 (1.39-1.81)] in LVV patients [2.55 (2.22-2.82), p < 0.005], GPA patients [2.17 (1.89-2.83), p < 0.005] and patients suffering from sarcoidosis [2.04 (1.88-2.20), p < 0.05]. In GPA patients, the mean TBR{sub max} of the aorta was significantly higher in patients with previous renal involvement [2.01 (1.69-2.53)] compared to patients without renal involvement in the past [1.60 (1.51-1.80), p < 0.05]. Interrater reproducibility with a second reader was high (all intraclass correlation coefficients >0.9). Patients suffering from GPA show marked aortic FDG uptake. (orig.)

  9. Computerized Classification Testing with the Rasch Model

    Science.gov (United States)

    Eggen, Theo J. H. M.

    2011-01-01

    If classification in a limited number of categories is the purpose of testing, computerized adaptive tests (CATs) with algorithms based on sequential statistical testing perform better than estimation-based CATs (e.g., Eggen & Straetmans, 2000). In these computerized classification tests (CCTs), the Sequential Probability Ratio Test (SPRT) (Wald,…

  10. Computerizing primary schools in rural kenya

    DEFF Research Database (Denmark)

    Ogembo, J.G.; Ngugi, B.; Pelowski, Matthew John

    2012-01-01

    questions surrounding this endeavour. Specifically: 1.) what problems do rural schools actually want to solve with computerization; 2.) is computerization the most important priority for rural schools; 3.) are schools ready, in terms of infrastructure, for a computer in the classroom; or 4.) might...... and protective roofing -posing severe challenges to the outstanding conception of computerization. We consider these results and make recommendations for better adapting programs for computer introduction, and also suggest the use of new innovative devices, such as cell phones, which might already have overcome......This paper investigates the outstanding challenges facing primary schools' computerization in rural Kenya. Computerization of schools is often envisaged as a 'magic', or at least a particularly efficient, solution to many of the problems that developing countries face in improving primary school...

  11. Psychometrics behind Computerized Adaptive Testing.

    Science.gov (United States)

    Chang, Hua-Hua

    2015-03-01

    The paper provides a survey of 18 years' progress that my colleagues, students (both former and current) and I made in a prominent research area in Psychometrics-Computerized Adaptive Testing (CAT). We start with a historical review of the establishment of a large sample foundation for CAT. It is worth noting that the asymptotic results were derived under the framework of Martingale Theory, a very theoretical perspective of Probability Theory, which may seem unrelated to educational and psychological testing. In addition, we address a number of issues that emerged from large scale implementation and show that how theoretical works can be helpful to solve the problems. Finally, we propose that CAT technology can be very useful to support individualized instruction on a mass scale. We show that even paper and pencil based tests can be made adaptive to support classroom teaching.

  12. Chinese computerized nuclear data library

    International Nuclear Information System (INIS)

    Liang Qichang; Cai Dunjiu

    1996-01-01

    The Second Version of Chinese Evaluated Nuclear Data Library (CENDL-2) includes the complete neutron nuclear data sets of 54 important elements and isotopes used for nuclear science and engineering with the incident neutron energy from 10 -5 eV to 20 MeV, the international universal format ENDF/B-6 was adopted. Now, the Chinese Computerized nuclear data library has been developed and put into operation. That is, the users can make on-line use of the main data libraries for evaluated neutron reaction data in the world of EXFOR experimental nuclear data library on the terminal of computer via the perfect computer software system, carry out directly the nuclear engineering calculation or nuclear data evaluation, enjoy the use of the resource of our nuclear data libraries for their development of nuclear energy and nuclear technology applications

  13. Computerized evaluation of flood impact

    International Nuclear Information System (INIS)

    Gagnon, J.; Quach, T.T.; Marche, C.; Lessard, G.

    1998-01-01

    A computerized evaluation process for assessing the economic impacts of a potential dam failure is described. The DOMINO software, which was developed by Hydro-Quebec, takes into account flow data from dam break simulations of floods, the territory involved, plus the economic evaluations of the real estate and infrastructures affected. Some examples of software applications and impact evaluations are presented. The principal elements involved in estimating economic or other types of impacts induced by natural flooding or dam failure, are: (1) flow forecasting, (2) defining the contour of the involved territory, and (3) accounting for the various impacts identified in the affected zone. Owing to its wide range of functions and utilities, DOMINO has proven to be a very useful, user-friendly and portable decision-making tool. 5 refs., 6 tabs

  14. Combined Allergic Bronchopulmonary Aspergillosis and Eosinophilic Granulomatosis with Polyangiitis: Three Cases and a Review of the Literature.

    Science.gov (United States)

    Ishiguro, Takashi; Takayanagi, Noboru; Takaku, Yotaro; Kagiyama, Naho; Kurashima, Kazuyoshi; Sugita, Yutaka

    2016-01-01

    Previous reports of combined allergic bronchopulmonary mycosis (ABPM) and eosinophilic granulomatosis with polyangiitis (EGPA) are limited; however, among 41 cases of ABPM and 18 cases of EGPA treated at our hospital, we experienced three cases of combined ABPM and EGPA. In two of these cases, the diagnosis of EGPA preceded that of ABPM, however, one of the two cases had already shown findings suggestive of ABPM, such as mucous plugs and central bronchiectasis, at the time of the diagnosis of EGPA. In six previously reported cases of combined ABPM and EGPA, ABPM preceded EGPA in four cases. In the other two cases in which EGPA was diagnosed before or simultaneously with ABPM, findings suggestive of ABPM had been detected when EGPA was diagnosed, which suggests that sensitization to fungi resulting in ABPM may play an important role in the development of EGPA. Careful attention should therefore be paid to the possibility that these diseases may coexist during the course of either disease.

  15. The use of abatacept in debilitating cavitating lung disease associated with rheumatoid arthritis, bronchocentric granulomatosis and aspergillosis.

    LENUS (Irish Health Repository)

    Neff, K

    2010-06-01

    A case of debilitating cavitating lung disease associated with rheumatoid arthritis and bronchocentric granulomatosis, which failed to respond to conventional medical or surgical treatment, is described. The patient was treated over 10 years with steroids, antimicrobial agents, disease-modifying antirheumatoid drugs and surgery. Lung function continued to decline and the patient presented for admission with recurrent pneumonia. Abatacept was initiated to modify the underlying immunopathology. Following 12 months of treatment with abatacept the patient has demonstrable improvement in lung function and lung anatomy, and has not presented to hospital with pneumonia. She has tolerated the treatment without complication. The use of abatacept has stabilised the lung disease in this case in the medium term and prevented readmission to hospital. These results suggest a larger role for abatacept in those with such disease in the future and may warrant further investigation.

  16. Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome) Complicated by Perforation of the Small Intestine and Cholecystitis.

    Science.gov (United States)

    Ohnuki, Yoichi; Moriya, Yusuke; Yutani, Sachiko; Mizuma, Atsushi; Nakayama, Taira; Ohnuki, Yuko; Uda, Shuji; Inomoto, Chie; Yamamoto, Soichiro; Nakamura, Naoya; Takizawa, Shunya

    2018-03-01

    We report a case of eosinophilic granulomatosis with polyangiitis (EGPA; formerly known as Churg-Strauss syndrome) complicated by perforation of the small intestine and necrotizing cholecystitis. A 69-year-old man with a history of bronchial asthma was admitted with mononeuritis multiplex. The laboratory findings included remarkable eosinophilia. He was treated with corticosteroids and his laboratory indices showed improvement; however, his functional deficits remained. His neuropathy gradually improved after the addition of intravenous immunoglobulin (IVIG). He was subsequently treated with oral prednisolone (40 mg/day) as maintenance therapy. Within a month after finishing IVIG, he developed perforation of the small intestine and necrotizing cholecystitis. Intestinal perforation has often been reported as a gastrointestinal complication of EGPA. In contrast, cholecystitis is a rare complication. We report this case because the manifestation of more than one complication is extremely rare. Gastrointestinal symptoms may be a complication of EGPA itself and/or immunosuppressive treatment.

  17. [Computerized medical record: deontology and legislation].

    Science.gov (United States)

    Allaert, F A; Dusserre, L

    1996-02-01

    Computerization of medical records is making headway for patients' follow-up, scientific research, and health expenses control, but it must not alter the guarantees provided to the patients by the medical code of ethics and the law of January 6, 1978. This law, modified on July 1, 1994, requires to register all computerized records of personal data and establishes rights to protect privacy against computer misdemeanor. All medical practitioners using computerized medical records must be aware that the infringement of this law may provoke suing in professional, civil or criminal court.

  18. Microcomputer Network for Computerized Adaptive Testing (CAT)

    Science.gov (United States)

    1984-03-01

    PRDC TR 84-33 \\Q.�d-33- \\ MICROCOMPUTER NETWOJlt FOR COMPUTERIZED ADAPTIVE TESTING ( CAT ) Baldwin Quan Thomas A . Park Gary Sandahl John H...ACCEIIION NO NPRDC TR 84-33 4. TITLE (-d Sul>tlllo) MICROCOMP UTER NETWORK FOR COMPUTERIZED ADA PTIVE TESTING ( CAT ) 1. Q B. uan T. A . Park...adaptive testing ( CAT ) Bayesian sequential testing 20. ABSTitACT (Continuo on ro•••• aide II noco .. _, _., ld-tlly ,.,. t.loclt _._.) DO Computerized

  19. Vasculitis Pregnancy Registry

    Science.gov (United States)

    2018-04-30

    Vasculitis; Behcet's Disease; CNS Vasculitis; Cryoglobulinemic Vasculitis; Eosinophilic Granulomatosis With Polyangiitis (EGPA); Churg-Strauss Syndrome (CSS); Granulomatosis With Polyangiitis (GPA); Wegener's Granulomatosis; IgA Vasculitis; Henoch-Schoenlein Purpura (HSP); Microscopic Polyangiitis (MPA); Polyarteritis Nodosa (PAN); Takayasu Arteritis (TAK); Urticarial Vasculitis; Systemic Vasculitis

  20. A computerized legal information management system | Ohiagu ...

    African Journals Online (AJOL)

    A computerized legal information management system. ... process through the filling system using the survey research methodology. ... A framework for the design and implementation of a legal information management system was presented.

  1. Computerizing marine biota: a rational approach

    Digital Repository Service at National Institute of Oceanography (India)

    Chavan, V.S.; Chandramohan, D.; Parulekar, A.H.

    Data on marine biota while being extensive are also patchy and scattered; thus making retrieval and dissemination of information time consuming. This emphasise the need for computerizing information on marine biota with the objective to collate...

  2. Human Reliability Analysis For Computerized Procedures

    International Nuclear Information System (INIS)

    Boring, Ronald L.; Gertman, David I.; Le Blanc, Katya

    2011-01-01

    This paper provides a characterization of human reliability analysis (HRA) issues for computerized procedures in nuclear power plant control rooms. It is beyond the scope of this paper to propose a new HRA approach or to recommend specific methods or refinements to those methods. Rather, this paper provides a review of HRA as applied to traditional paper-based procedures, followed by a discussion of what specific factors should additionally be considered in HRAs for computerized procedures. Performance shaping factors and failure modes unique to computerized procedures are highlighted. Since there is no definitive guide to HRA for paper-based procedures, this paper also serves to clarify the existing guidance on paper-based procedures before delving into the unique aspects of computerized procedures.

  3. Computerized Interpretation of Dynamic Breast MRI

    National Research Council Canada - National Science Library

    Chen, Weijie; Giger, Maryellen Lissak

    2005-01-01

    ... and prognosis of breast cancer. The research involves investigation of automatic methods for image artifacts correction, tumor segmentation, and extraction of computerized features that help distinguish between benign and malignant lesions...

  4. Computerized provider order entry systems.

    Science.gov (United States)

    2001-01-01

    Computerized provider order entry (CPOE) systems are designed to replace a hospital's paper-based ordering system. They allow users to electronically write the full range of orders, maintain an online medication administration record, and review changes made to an order by successive personnel. They also offer safety alerts that are triggered when an unsafe order (such as for a duplicate drug therapy) is entered, as well as clinical decision support to guide caregivers to less expensive alternatives or to choices that better fit established hospital protocols. CPOE systems can, when correctly configured, markedly increase efficiency and improve patient safety and patient care. However, facilities need to recognize that currently available CPOE systems require a tremendous amount of time and effort to be spent in customization before their safety and clinical support features can be effectively implemented. What's more, even after they've been customized, the systems may still allow certain unsafe orders to be entered. Thus, CPOE systems are not currently a quick or easy remedy for medical errors. ECRI's Evaluation of CPOE systems--conducted in collaboration with the Institute for Safe Medication Practices (ISMP)--discusses these and other related issues. It also examines and compares CPOE systems from three suppliers: Eclipsys Corp., IDX Systems Corp., and Siemens Medical Solutions Health Services Corp. Our testing focuses primarily on the systems' interfacing capabilities, patient safeguards, and ease of use.

  5. Computerized automated remote inspection system

    International Nuclear Information System (INIS)

    The automated inspection system utilizes a computer to control the location of the ultrasonic transducer, the actual inspection process, the display of the data, and the storage of the data on IBM magnetic tape. This automated inspection equipment provides two major advantages. First, it provides a cost savings, because of the reduced inspection time, made possible by the automation of the data acquisition, processing, and storage equipment. This reduced inspection time is also made possible by a computerized data evaluation aid which speeds data interpretation. In addition, the computer control of the transducer location drive allows the exact duplication of a previously located position or flaw. The second major advantage is that the use of automated inspection equipment also allows a higher-quality inspection, because of the automated data acquisition, processing, and storage. This storage of data, in accurate digital form on IBM magnetic tape, for example, facilitates retrieval for comparison with previous inspection data. The equipment provides a multiplicity of scan data which will provide statistical information on any questionable volume or flaw. An automatic alarm for location of all reportable flaws reduces the probability of operator error. This system has the ability to present data on a cathode ray tube as numerical information, a three-dimensional picture, or ''hard-copy'' sheet. One important advantage of this system is the ability to store large amounts of data in compact magnetic tape reels

  6. Evaluation of GPM IMERG Early, Late, and Final rainfall estimates using WegenerNet gauge data in southeastern Austria

    Science.gov (United States)

    O, Sungmin; Foelsche, Ulrich; Kirchengast, Gottfried; Fuchsberger, Juergen; Tan, Jackson; Petersen, Walter A.

    2017-12-01

    The Global Precipitation Measurement (GPM) Integrated Multi-satellite Retrievals for GPM (IMERG) products provide quasi-global (60° N-60° S) precipitation estimates, beginning March 2014, from the combined use of passive microwave (PMW) and infrared (IR) satellites comprising the GPM constellation. The IMERG products are available in the form of near-real-time data, i.e., IMERG Early and Late, and in the form of post-real-time research data, i.e., IMERG Final, after monthly rain gauge analysis is received and taken into account. In this study, IMERG version 3 Early, Late, and Final (IMERG-E,IMERG-L, and IMERG-F) half-hourly rainfall estimates are compared with gauge-based gridded rainfall data from the WegenerNet Feldbach region (WEGN) high-density climate station network in southeastern Austria. The comparison is conducted over two IMERG 0.1° × 0.1° grid cells, entirely covered by 40 and 39 WEGN stations each, using data from the extended summer season (April-October) for the first two years of the GPM mission. The entire data are divided into two rainfall intensity ranges (low and high) and two seasons (warm and hot), and we evaluate the performance of IMERG, using both statistical and graphical methods. Results show that IMERG-F rainfall estimates are in the best overall agreement with the WEGN data, followed by IMERG-L and IMERG-E estimates, particularly for the hot season. We also illustrate, through rainfall event cases, how insufficient PMW sources and errors in motion vectors can lead to wide discrepancies in the IMERG estimates. Finally, by applying the method of Villarini and Krajewski (2007), we find that IMERG-F half-hourly rainfall estimates can be regarded as a 25 min gauge accumulation, with an offset of +40 min relative to its nominal time.

  7. Computerized Adaptive Personality Testing: A Review and Illustration With the MMPI-2 Computerized Adaptive Version.

    Science.gov (United States)

    Forbey, Johnathan D.; Ben-Porath, Yossef S.

    2007-01-01

    Computerized adaptive testing in personality assessment can improve efficiency by significantly reducing the number of items administered to answer an assessment question. Two approaches have been explored for adaptive testing in computerized personality assessment: item response theory and the countdown method. In this article, the authors…

  8. Evaluation of brain scintigraphy and computerized tomography

    International Nuclear Information System (INIS)

    Cavailloles, F.; Dairou, R.; Desbleds, M.T.; Benoit, C.; Larmande, P.; Bok, B.; Alperovitch, A.

    1983-01-01

    In order to assess the clinical usefulness of brain computerized tomography and radionuclide scan, a prospective study was performed on a series of 554 patients. The detection rate was assessed as well as the identification rate of lesions. In addition, the usefulness of both tests was appreciated subjectively by two neurologists reviewing the patients' files. Both give reasonably similar results: computerized tomography is superior to radionuclide scan in the diagnosis of tumors and intracerebral hematomas, the radionuclide scan being slightly superior in the diagnosis of purely ischemic CVA and subdural hematomas. The superiority which was subjectively conceded to computerized tomography was greater than that objectively demonstrated. However, clinical usefulness of computerized tomography was judged important in only 50% of the cases. Moreover, to request both computerized tomography and radionuclide scan appeared as having no interest in 83% of the cases. In that series, the diagnostic hypotheses were in agreement with the final diagnosis in 88% of the cases. Bias encountered in this type of studies are discussed [fr

  9. Computerized occlusal analysis in bruxism

    Directory of Open Access Journals (Sweden)

    Lazić Vojkan

    2006-01-01

    Full Text Available Introduction. Sleep bruxism as nocturnal parafunction, also known as tooth grinding, is the most common parasomnia (sleep disorder. Most tooth grinding occurs during rapid eye movement - REM sleep. Sleep bruxism is an oral habit characterized by rhythmic activity of the masticatory muscles (m. masseter that causes forced contact between dental surfaces during sleep. Sleep bruxism has been associated with craniomandibular disorders including temporomandibular joint discomfort, pulpalgia, premature loss of teeth due to excessive attrition and mobility, headache, muscle ache, sleep interruption of an individual and problems with removable and fixed denture. Basically, two groups of etiological factors can be distinguished, viz., peripheral (occlusal factors and central (pathophysiological and psychological factors. The role of occlusion (occlusal discrepancies as the causative factor is not enough mentioned in relation to bruxism. Objective. The main objective of this paper was to evaluate the connection between occlusal factors and nocturnal parafunctional activities (occlusal disharmonies and bruxism. Method. Two groups were formed- experimental of 15 persons with signs and symptoms of nocturnal parafunctional activity of mandible (mean age 26.6 years and control of 42 persons with no signs and symptoms of bruxism (mean age 26.3 yrs.. The computerized occlusal analyses were performed using the T-Scan II system (Tekscan, Boston, USA. 2D occlusograms were analyzed showing the occlusal force, the center of the occlusal force with the trajectory and the number of antagonistic tooth contacts. Results. Statistically significant difference of force distribution was found between the left and the right side of the arch (L%-R% (t=2.773; p<0.02 in the group with bruxism. The difference of the centre of occlusal force - COF trajectory between the experimental and control group was not significant, but the trajectory of COF was longer in the group of

  10. Formal Verification of Computerized Procedure with Colored Petri Nets

    International Nuclear Information System (INIS)

    Kim, Yun Goo; Shin, Yeong Cheol

    2008-01-01

    Computerized Procedure System (CPS) supports nuclear power plant operators in performing operating procedures which are instructions to guide in monitoring, decision making and controlling nuclear power plants. Computerized Procedure (CP) should be loaded to CPS. Due to its execution characteristic, computerized procedure acts like a software in CPS. For example, procedure flows are determined by operator evaluation and computerized procedure logic which are pre-defined. So the verification of Computerized Procedure logic and execution flow is needed before computerized procedures are installed in the system. Formal verification methods are proposed and the modeling of operating procedures with Coloured Petri Nets(CP-nets) is presented

  11. Evaluation of GPM IMERG Early, Late, and Final rainfall estimates using WegenerNet gauge data in southeastern Austria

    Directory of Open Access Journals (Sweden)

    S. O

    2017-12-01

    Full Text Available The Global Precipitation Measurement (GPM Integrated Multi-satellite Retrievals for GPM (IMERG products provide quasi-global (60° N–60° S precipitation estimates, beginning March 2014, from the combined use of passive microwave (PMW and infrared (IR satellites comprising the GPM constellation. The IMERG products are available in the form of near-real-time data, i.e., IMERG Early and Late, and in the form of post-real-time research data, i.e., IMERG Final, after monthly rain gauge analysis is received and taken into account. In this study, IMERG version 3 Early, Late, and Final (IMERG-E,IMERG-L, and IMERG-F half-hourly rainfall estimates are compared with gauge-based gridded rainfall data from the WegenerNet Feldbach region (WEGN high-density climate station network in southeastern Austria. The comparison is conducted over two IMERG 0.1°  ×  0.1° grid cells, entirely covered by 40 and 39 WEGN stations each, using data from the extended summer season (April–October for the first two years of the GPM mission. The entire data are divided into two rainfall intensity ranges (low and high and two seasons (warm and hot, and we evaluate the performance of IMERG, using both statistical and graphical methods. Results show that IMERG-F rainfall estimates are in the best overall agreement with the WEGN data, followed by IMERG-L and IMERG-E estimates, particularly for the hot season. We also illustrate, through rainfall event cases, how insufficient PMW sources and errors in motion vectors can lead to wide discrepancies in the IMERG estimates. Finally, by applying the method of Villarini and Krajewski (2007, we find that IMERG-F half-hourly rainfall estimates can be regarded as a 25 min gauge accumulation, with an offset of +40 min relative to its nominal time.

  12. Computerized tomography in orthopaedics and traumatology

    International Nuclear Information System (INIS)

    Boettger, E.; Heckl, R.; Rehabilitations-Krankenhaus Langensteinbach, Karlsbad

    1981-01-01

    Computerized tomography in traumatology is the selected method for the indications mentioned, so that angiographic investigations are only necessary in exceptional cases. Computerized tomography is also better than other methods when diagnozing soft part tumours, however, angiography is still indicated preoperatively for individual cases. CT is only good as additional help to conventional diagnostics with bone tumours. The differential diagnosis cysts-tumour is possible using contrast medium injections. The frequently large soft part share of tumours is recognizable with osteolytic tumours so that a better irradiation and operation planning can be effected. Diseases in the spinal canal can only be assessed with reservation using modern equipment. Lumbar dislocations of the disk can mostly not be sufficiently determined. Perivertebral abscesses can be certainly detected using computerized tomography. This is particularly so for abscesses prior to calcification. (orig.) [de

  13. Computerized management of plant intervention tasks

    International Nuclear Information System (INIS)

    Remacle, J.; Quoidbach, G.

    1993-01-01

    The concept of 'computerized management' of plant intervention tasks was developed by TRACTEBEL in 1983 for the Belgian power plants of ELECTRABEL. The main objective of the 'Computerized Management of Plant Intervention Tasks' is to help the staff of a nuclear or a conventional power plant in planning, organizing, and carrying out any (preventive or corrective) maintenance task. It consists of a group of interconnected functional modules acting on a unique and homogeneous data base. A short description of 3 modules is given, i.e., the 'User' Module, the 'Equipment' Module and the 'Periodic Procedure' Module. (Z.S.)

  14. Computerization of the safeguards analysis decision process

    International Nuclear Information System (INIS)

    Ehinger, M.H.

    1990-01-01

    This paper reports that safeguards regulations are evolving to meet new demands for timeliness and sensitivity in detecting the loss or unauthorized use of sensitive nuclear materials. The opportunities to meet new rules, particularly in bulk processing plants, involve developing techniques which use modern, computerized process control and information systems. Using these computerized systems in the safeguards analysis involves all the challenges of the man-machine interface experienced in the typical process control application and adds new dimensions to accuracy requirements, data analysis, and alarm resolution in the regulatory environment

  15. Computerized tomography in the diagnosis of hyperparathyroidism

    International Nuclear Information System (INIS)

    Sobota, J.; Girl, J.; Sotornik, I.; Kocandrle, V.

    1990-01-01

    Long-term experience in the application of computerized tomography to the diagnosis of hyperparathyroidism is summarized. Based on a large number of examinations (164) of parathyroid glands associated with the possibility of verification and comparison with the results of ultrasonography and other imaging methods, the potential of computerized tomography in the diagnosis of hyperparathyroidism and its advantages and limitations are summarized. It is concluded that owing to its high diagnostic precision, this technique can be regarded reliable in detecting enlarged parathyroid glands. (author). 11 figs., 1 tab., 19 refs

  16. A nationwide survey on the epidemiology and clinical features of eosinophilic granulomatosis with polyangiitis (Churg-Strauss) in Japan.

    Science.gov (United States)

    Sada, Ken-Ei; Amano, Koichi; Uehara, Ritei; Yamamura, Masahiro; Arimura, Yoshihiro; Nakamura, Yoshikazu; Makino, Hirofumi

    2014-07-01

    We conducted a cross-sectional nationwide survey to determine eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) prevalence and clinical features in Japan. Data for EGPA patients in 2008 were collected from 1,564 hospitals. In total, 965 patients were reported from 365 departments. In a second survey, clinical data for 473 patients were obtained. We estimated that 1,866 (95% CI: 1,640-2,092) patients have EGPA in Japan (prevalence, 17.8/1,000,000). Of the 473 patients in the second survey, 315 fulfilled American College of Rheumatology (ACR) criteria or Lanham's criteria for EGPA. The mean age (± SD) of the 315 at onset was 55 ± 14 years, male to female ratio 1:2. 93% of patients had neurological manifestations, which were the organ system most frequently involved. Among 277 patients tested for myeloperoxidase (MPO)-/p anti-neutrophil cytoplasmic antibody (ANCA), 139 (50%) were positive, while only 6 of 238 were positive for proteinase3 (PR3)-/cANCA. MPO-ANCA-positive patients had renal involvement, mucous membrane or ophthalmological symptoms, and ENT symptoms more frequently, whereas cutaneous lesions and cardiovascular involvement were less common. The prevalence of EGPA and the frequency of MPO-/p-ANCA-positivity in Japanese EGPA patients were mostly similar to those of Western countries. However, female predominance and a high frequency of neurological manifestations characterized Japanese patients.

  17. The Origin of Continents and Oceans : A. Wegener (translated by J. Biram from the 4th revised German edition, 1929) Dover, New York N.Y., 1966, 246 pp., 63 illus., paperbound U.S.$2.00

    NARCIS (Netherlands)

    Bemmelen, R.W. van

    In the old controversy between fixism and mobilism a new scientific tool, palaeomagnetism, has recently brought forward independent diagnostic facts. In the discussions about drift many authors quote Wegener's classic work. It is fortunate that it has now appeared in an excellent English translation

  18. Robinson's Computerized Strabismus Model Comes of Age

    NARCIS (Netherlands)

    H.J. Simonsz (Huib); H. Spekreijse (Henk)

    1996-01-01

    textabstractIn this article we review our further development of D.A. Robinson's computerized strabismus model. First, an extensive literature study has been carried out to get more accurate data on the anatomy of the average eye and the eye muscles, and about how these vary with age and with

  19. Computerized Italian criticality guide, description and validation

    International Nuclear Information System (INIS)

    Carotenuto, M.; Landeyro, P.A.

    1988-10-01

    Our group is developing an 'expert system' for collecting engineering know-how on back-end nuclear plant design. An expert system is the most suitable software tool for our problem. During the analysis, the design process was divided into different branches. At each branch of the design process the Expert System relates a computerized design procedure. Any design procedure is composed of a set of design methods, together with their condition of application and reliability limits. In the framework of this expert system, the nuclear criticality safety analysis procedure was developed, in the form of a computerized criticality guide, attempting to reproduce the designer's normal 'reasoning' process. The criticality guide is composed of two parts: A computerized text, including theory, a description of the accidents occurred in the past and a description of the italian design experience; An interactive computer aided calculation module, containing a graphical facility for critical parameter curves. In the present report are presented the criticality guide (computerized Italian Criticality Guide) and its validation test. (author)

  20. Computerized management information systems and organizational structures

    Science.gov (United States)

    Zannetos, Z. S.; Sertel, M. R.

    1970-01-01

    The computerized management of information systems and organizational structures is discussed. The subjects presented are: (1) critical factors favoring centralization and decentralization of organizations, (2) classification of organizations by relative structure, (3) attempts to measure change in organization structure, and (4) impact of information technology developments on organizational structure changes.

  1. Some procedures for computerized ability testing

    NARCIS (Netherlands)

    van der Linden, Willem J.; Zwarts, Michel A.

    1989-01-01

    For computerized test systems to be operational, the use of item response theory is a prerequisite. As opposed to classical test theory, in item response models the abilities of the examinees and the properties of the items are parameterized separately. Hence, when measuring the abilities of

  2. Implementation of a Computerized Maintenance Management System

    Science.gov (United States)

    Shen, Yong-Hong; Askari, Bruce

    1994-01-01

    A primer Computerized Maintenance Management System (CMMS) has been established for NASA Ames pressure component certification program. The CMMS takes full advantage of the latest computer technology and SQL relational database to perform periodic services for vital pressure components. The Ames certification program is briefly described and the aspects of the CMMS implementation are discussed as they are related to the certification objectives.

  3. Computerizing Maintenance Management Improves School Processes.

    Science.gov (United States)

    Conroy, Pat

    2002-01-01

    Describes how a Computerized Maintenance Management System (CMMS), a centralized maintenance operations database that facilitates work order procedures and staff directives, can help individual school campuses and school districts to manage maintenance. Presents the benefits of CMMS and things to consider in CMMS selection. (EV)

  4. The limited angle problem in computerized tomography

    International Nuclear Information System (INIS)

    Louis, A.K.

    1984-01-01

    Fast reconstruction formulae in X-ray computerized tomography demand the directions, in which the measurements are taken, to be equally distributed over the whole circle. In many applications data can only be provided in a restricted range. Here the intrinsic difficulties are studied by giving a singular value decomposition of the Radon transform in a restricted range. Practical limitations are deduced. (orig.)

  5. Ethics and the Computerization of Pharmacy.

    Science.gov (United States)

    McCarthy, Robert L.; Perrolle, Judith A.

    1991-01-01

    The current and potential impact of computerization on pharmacy practice is discussed, focusing on ethical dilemmas in the pharmacist-patient relationship, confidentiality of records, and the role of artificial intelligence in decision making about drug therapy. Case studies for use by teachers of pharmaceutical ethics are provided. (Author/MSE)

  6. Individual Differences in Computerized Adaptive Testing.

    Science.gov (United States)

    Kim, JinGyu

    Research on the major computerized adaptive testing (CAT) strategies is reviewed, and some findings are reported that examine effects of examinee demographic and psychological characteristics on CAT strategies. In fixed branching strategies, all examinees respond to a common routing test, the score of which is used to assign examinees to a…

  7. Computerized management support for swine breeding farms

    NARCIS (Netherlands)

    Huirne, R.B.M.

    1990-01-01

    1. INTRODUCTION

    The investigations described in this thesis have been directed towards computerized management support for swine breeding farms, focused on sow productivity and profitability. The study is composed of three basic parts: (1) basic description and

  8. Computerized three-dimensional normal atlas

    International Nuclear Information System (INIS)

    Mano, Isamu; Suto, Yasuzo; Suzuki, Masataka; Iio, Masahiro.

    1990-01-01

    This paper presents our ongoing project in which normal human anatomy and its quantitative data are systematically arranged in a computer. The final product, the Computerized Three-Dimensional Normal Atlas, will be able to supply tomographic images in any direction, 3-D images, and coded information on organs, e.g., anatomical names, CT numbers, and T 1 and T 2 values. (author)

  9. The Computerized Reference Department: Buying the Future.

    Science.gov (United States)

    Kriz, Harry M.; Kok, Victoria T.

    1985-01-01

    Basis for systematic computerization of academic research library's reference, collection development, and collection management functions emphasizes productivity enhancement for librarians and support staff. Use of microcomputer and university's mainframe computer to develop applications of database management systems, electronic spreadsheets,…

  10. Computerized system for measuring cerebral metabolism

    International Nuclear Information System (INIS)

    McGlone, J.S.; Hibbard, L.S.; Hawkins, R.A.; Kasturi, R.

    1987-01-01

    A computerized stereotactic measurement system for evaluating rat brain metabolism was developed to utilize the large amount of data generated by quantitative autoradiography. Conventional methods of measurement only analyze a small percent of these data because these methods are limited by instrument design and the subjectiveness of the investigator. However, a computerized system allows digital images to be analyzed by placing data at their appropriate three-dimensional stereotactic coordinates. The system automatically registers experimental data to a standard three-dimensional image using alignment, scaling, and matching operations. Metabolic activity in different neuronal structures is then measured by generating digital masks and superimposing them on to experimental data. Several experimental data sets were evaluated and it was noticed that the structures measured by the computerized system, had in general, lower metabolic activity than manual measurements had indicated. This was expected because the computerized system measured the structure over its volume while the manual readings were taken from the most active metabolic area of a particular structure

  11. How will computerization revolutionize managed care?

    Science.gov (United States)

    Trabin, T

    1994-01-01

    Computerization of behavioral health care information systems is revolutionizing how payors, managed care companies, and providers exchange information. In this article, an imaginary scenario is depicted of how patient data will be accessed and communicated to facilitate care management of behavioral health care services in the near future.

  12. Computerized Italian criticality guide, description and validation

    Energy Technology Data Exchange (ETDEWEB)

    Carotenuto, M; Landeyro, P A [ENEA - Dipartimento Ciclo del Combustibile, Centro Ricerche Energia, Casaccia (Italy)

    1988-10-15

    Our group is developing an 'expert system' for collecting engineering know-how on back-end nuclear plant design. An expert system is the most suitable software tool for our problem. During the analysis, the design process was divided into different branches. At each branch of the design process the Expert System relates a computerized design procedure. Any design procedure is composed of a set of design methods, together with their condition of application and reliability limits. In the framework of this expert system, the nuclear criticality safety analysis procedure was developed, in the form of a computerized criticality guide, attempting to reproduce the designer's normal 'reasoning' process. The criticality guide is composed of two parts: A computerized text, including theory, a description of the accidents occurred in the past and a description of the italian design experience; An interactive computer aided calculation module, containing a graphical facility for critical parameter curves. In the present report are presented the criticality guide (computerized Italian Criticality Guide) and its validation test. (author)

  13. Geometrical efficiency in computerized tomography: generalized model

    International Nuclear Information System (INIS)

    Costa, P.R.; Robilotta, C.C.

    1992-01-01

    A simplified model for producing sensitivity and exposure profiles in computerized tomographic system was recently developed allowing the forecast of profiles behaviour in the rotation center of the system. The generalization of this model for some point of the image plane was described, and the geometrical efficiency could be evaluated. (C.G.C.)

  14. Computerized reactor monitor and control for research reactors

    International Nuclear Information System (INIS)

    Buerger, L.; Vegh, E.

    1981-09-01

    The computerized process control system developed in the Central Research Institute for Physics, Budapest, Hungary, is described together with its special applications at research reactors. The nuclear power of the Hungarian research reactor is controlled by this computerized system, too, while in Lybia many interesting reactor-hpysical calculations are built into the computerized monitor system. (author)

  15. 39 CFR 501.15 - Computerized Meter Resetting System.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Computerized Meter Resetting System. 501.15... AND DISTRIBUTE POSTAGE EVIDENCING SYSTEMS § 501.15 Computerized Meter Resetting System. (a) Description. The Computerized Meter Resetting System (CMRS) permits customers to reset their postage meters at...

  16. Cardiac tamponade leading to the diagnosis of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a case report and review of the literature.

    Science.gov (United States)

    Yano, Toshiyuki; Ishimura, Shutaro; Furukawa, Tetsuaki; Koyama, Masayuki; Tanaka, Marenao; Shimoshige, Shinya; Hashimoto, Akiyoshi; Miura, Tetsuji

    2015-11-01

    Eosinophilic granulomatosis with polyangiitis (EGPA), which was previously called Churg-Strauss syndrome, is a necrotizing systemic vasculitis of unknown cause accompanied by prominent eosinophilia. Cardiovascular complications, including eosinophilic myocarditis, are a major cause of mortality in this disorder. Acute pericarditis with slight pericardial effusion is a typical manifestation in EGPA, though hemodynamically significant pericardial effusion has been reported in a few cases. We report a case that initially presented with isolated cardiac tamponade, which was followed by systemic manifestations of EGPA over 3 weeks. Including the present case, previous EGPA cases with cardiac tamponade are reviewed to delineate its clinical characteristics.

  17. Risk factors and treatment of pneumothorax secondary to granulomatosis with polyangiitis: a clinical analysis of 25 cases.

    Science.gov (United States)

    Shi, Xuhua; Zhang, Yongfeng; Lu, Yuewu

    2018-01-15

    To investigate the risk factors and treatment strategies for pneumothorax secondary to granulomatosis with polyangiitis (GPA). Retrospective analysis of cases with pneumothorax secondary to GPA from our own practice and published on literature. A total of 25 patients, 18 males and 7 females, mean age 44 ± 15.7 years, were analyzed. Diagnosis included pneumothorax (11 cases), hydropneumothorax (n = 5), empyema (n = 8) and hemopneumothorax (n = 1). 88% (22/25) patients showed single/multiple pulmonary/ subpleural nodules with/without cavitation on chest imaging. Erythrocyte sedimentation rate and C-reactive protein were both elevated. Corticosteroids and immunosuppressive agents were used in 16 cases. Five cases received steroid pulse therapy, of which 4 patients survived. Pleural drainage was effective in some patients. Seven patients underwent surgical operations. In the 10 fatal cases, infection and respiratory failure were the most common cause. Lung biopsy/ autopsy showed lung/pleural necrotizing granulomatous vasculitis, breaking into the chest cavity, pleural fibrosis, bronchial pleural fistula, etc. The mean age in the death group was greater than the survival group (53 ± 12.9 years vs 40.1 ± 14.7 years, p = 0.05), the ineffective pleural drainage was also higher in the death group (5/5 vs 0/7, p = 0.01). Pneumothorax was seen in the active GPA, due to a variety of reasons, and gave rise to high fatality rate. Aggressive treatment of GPA can improve the prognosis. Older and lack of response for pleural drainage indicates poor prognosis.

  18. Relationship among antineutrophil cytoplasmic antibody, blood urea nitrogen and complement in patients with eosinophilic granulomatosis polyangiitis (Churg-Strauss syndrome).

    Science.gov (United States)

    Kawakami, Tamihiro; Kimura, Satoko; Takeuchi, Sora; Soma, Yoshinao

    2013-07-01

    Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg-Strauss syndrome, is an antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis characterized by a history of asthma, hypereosinophilia. The prevalence of ANCA in EGPA is less common than in other ANCA-associated vasculitis. Increasing evidence of complement activation in the pathogenesis of ANCA-associated vasculitis has been provided by studies in animal models. We examined EGPA patients with cutaneous manifestations as an initial sign and investigated the correlations among clinical, serological and histopathological findings. We focused on differences among ANCA, blood urea nitrogen and complement levels such as complement 3 (C3), C4 and total complement hemolytic activity (CH50). We retrospectively investigated the records of 22 patients (11 male and 11 female) with EGPA admitted to our hospital from 1997-2012. Ten of the 22 patients (46%) were positive for serum myeloperoxidase (MPO)-ANCA. In contrast, all the patients were negative for serum proteinase 3 ANCA. There was a significantly positive correlation between serum CH50 and C4 levels in patients with EGPA. Serum blood urea nitrogen (BUN) levels differed significantly between MPO-ANCA-positive and -negative patients. Serum CH50 levels were higher in MPO-ANCA-positive patients compared to negative patients. Serum BUN levels were higher in elevated CH50 patients compared to normal and low CH50-negative patients. We propose that positive findings for MPO-ANCA with CH50 high activity may be a risk factor for developing renal insufficiency. Assuming there are correlations between the presence of ANCA and complements, earlier diagnosis based on initial efficacious treatment for EGPA. © 2013 Japanese Dermatological Association.

  19. Childhood-onset eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome): a contemporary single-center cohort.

    Science.gov (United States)

    Gendelman, Samantha; Zeft, Andrew; Spalding, Steven J

    2013-06-01

    To date only 38 cases of childhood-onset eosinophilic granulomatosis with polyangiitis (cEGPA; formerly Churg-Strauss syndrome) have been reported. Additional patients with cEGPA could enhance the understanding of this rare and life-threatening condition. Our objectives were (1) to determine the frequency of specific organ system involvement; (2) to examine initial therapeutic regimen; and (3) to document disease and therapy-related morbidity in a contemporary cohort of patients with cEGPA. Retrospective review of patients evaluated at the Cleveland Clinic between 2003 and 2011 who met either American College of Rheumatology or Lanham criteria for EGPA and whose age was < 18 years at symptom onset. Nine patients (8 female; 7 white) were identified. Median age at onset of rhinitis/asthma symptom was 13 years and median age at diagnosis of cEGPA was 15 years. All patients demonstrated eosinophilia, upper airway disease (allergic rhinitis, chronic sinusitis, and/or nasal polyps), and pulmonary involvement. Other frequently involved organ systems included musculoskeletal (67%), gastrointestinal (67%), cutaneous (67%), neurologic (56%), and cardiac (44%). Antineutrophil cytoplasmic antibody (ANCA) serologies were negative in all patients. The medications used most frequently for initial therapy included oral (44%) or intravenous corticosteroids (56%) and azathioprine (67%). Disease or therapeutic complications occurred in half of the cohort and included heart failure, stroke, and sequela from longterm, high-dose steroids. Eosinophilia, in combination with upper airway, pulmonary, musculoskeletal, neurologic, and cardiac manifestations, is frequently observed in cEGPA. ANCA titers are often negative. Steroids are the mainstay of initial therapy but steroid-related side effects occur regularly.

  20. Computerized tomography in atypical Pott's disease

    International Nuclear Information System (INIS)

    Cabrera, M.N.B.; Wang, E.H.M.

    1993-01-01

    Classical Pott's disease is described as a two-vertebrae disease with the destruction of the intervening invertebral disc. Computerized tomography has been used in the differential diagnosis of spine infections and neoplasms. We reviewed CT scans of patients seen at the Philippine General Hospital over a two-year period with atypical presentations of atypical tuberculous spondylitis. We used the computerized tomography findings described as characteristic of classical Pott's disease as criteria in evaluating the CT scans of patients diagnosed to have Atypical Pott's Disease. Although the number of patients prevented sensitivity and specificity studies to be done, our results strongly suggest that the same CT criteria used to diagnose Classical Pott's Disease may also be used to diagnose Pott's disease in its atypical form. (Author.). 13 refs

  1. Computerized flow monitors detect small kicks

    Energy Technology Data Exchange (ETDEWEB)

    McCann, D.; White, D. (Sedco Forex, Paris (FR))

    1992-02-24

    This paper reports on a smart alarm system installed on a number of offshore rigs and one land rig which can detect kicks more quickly than conventional systems. This rapid kick detection improves rig safety because the smaller the detected influx, the easier it is to control the well. The extensive computerized monitoring system helps drilling personnel detect fluid influxes and fluid losses before the changes in flow would normally be apparent.

  2. The EORTC emotional functioning computerized adaptive test

    DEFF Research Database (Denmark)

    Gamper, Eva-Maria; Grønvold, Mogens; Petersen, Morten Aa

    2014-01-01

    The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group is currently developing computerized adaptive testing measures for the Quality of Life Questionnaire Core-30 (QLQ-C30) scales. The work presented here describes the development of an EORTC item bank for e...... for emotional functioning (EF), which is one of the core domains of the QLQ-C30....

  3. 10 years of computerized tomography reviewed

    International Nuclear Information System (INIS)

    Duemmling, K.

    1984-01-01

    The history and some highlights of computerized tomography are reviewed. The various technologies employed in the course of CT development are described along with the limitations that led to their disappearance. The problems still to be solved in medicine, the increasing influence of nuclear magnetic resonance, and some scientific aspects have opened up new lines of development which are briefly mentioned. (orig./WU) [de

  4. Computerized reactor pressure vessel materials information system

    International Nuclear Information System (INIS)

    Strosnider, J.; Monserrate, C.; Kenworthy, L.D.; Tether, C.D.

    1980-10-01

    A computerized information system for storage and retrieval of reactor pressure vessel materials data was established, as part of Task Action Plan A-11, Reactor Vessel Materials Toughness. Data stored in the system are necessary for evaluating the resistance of reactor pressure vessels to flaw-induced fracture. This report includes (1) a description of the information system; (2) guidance on accessing the system; and (3) a user's manual for the system

  5. Computerized reactor power regulation with logarithmic controller

    International Nuclear Information System (INIS)

    Gossanyi, A.; Vegh, E.

    1982-11-01

    A computerized reactor control system has been operating at a 5 MW WWR-SM research reactor in the Central Research Institute for Physics, Budapest, for some years. This paper describes the power controller used in the SPC operating mode of the system, which operates in a 5-decade wide power range with +-0.5% accuracy. The structure of the controller easily limits the minimal reactor period and produces a reactor transient with constant period if the power demand changes. (author)

  6. COMPRESS - a computerized reactor safety system

    International Nuclear Information System (INIS)

    Vegh, E.

    1986-01-01

    The computerized reactor safety system, called COMPRESS, provides the following services: scram initiation; safety interlockings; event recording. The paper describes the architecture of the system and deals with reliability problems. A self-testing unit checks permanently the correct operation of the independent decision units. Moreover the decision units are tested by short pulses whether they can initiate a scram. The self-testing is described in detail

  7. Computerized UT system for stud bolt

    International Nuclear Information System (INIS)

    Kisanuki, T.; Uchida, K.; Fushimi, T.; Onda, K.

    1988-01-01

    Cracking of stud bolts used in steam turbine casing, valve and pressure vessel has caused concern regarding the safety and reliability of power plants. In order to detect harmful cracks in early state, the improvement of UT technique is required. As regarding the ultrasonic inspection technique, a longitudinal beam technique and/or an angle beam technique are generally used. The authors report their development of a computerized UT system for bolt inspection and improvement of the angle beam technique

  8. Computerized tomography of gall bladder cancer

    International Nuclear Information System (INIS)

    Todua, F.I.; Karmazanovskij, G.G.

    1989-01-01

    The authors have summed up the experience in the use of computerized tomography (CT) in diagnosis of gall bladder cancer. The investigation of 17 patients with cancer of this site showed a high informative value of the method. A retrospective comparative study of the results of CT and surgical interventions was carried out. It has been concluded that CT makes it possible not only to diagnose malignant lesions of the bile ducts but also to assess a possible scope of a forthcoming operation

  9. Computerized dosimetry management systems within EDF

    International Nuclear Information System (INIS)

    Daubert, G.

    1996-01-01

    EDF, using the ALARA approach, has embarked an ambitious project of optimising the doses received in its power plants. In directing its choice of actions and the effectiveness of such actions, the French operator is using a computerized personal and collective dosimetry management system. This system provides for ongoing monitoring of dosimetry at personal, site and unit level or indeed for the entire population of EDF nuclear power plants. (author)

  10. Increased intracranial pressure: evaluation by computerized tomography

    International Nuclear Information System (INIS)

    Lightfoote, W.E.; Pressman, B.D.

    1975-01-01

    Computerized tomography is clearly very useful in the evaluation of patients with increased intracranial pressure and suspected pseudotumor cerebri. It provides an index of ventricular size and configuration and has the capability of demonstrating intracranial lesions. Moreover, this new technique is rapid and non-invasive, and is without attendant risks. Examinations may be performed serially as the clinical process evolves, thereby giving roentgenographic correlation to the clinical features. (U.S.)

  11. Computerized tomographic diagnosis of basal skull fracture

    International Nuclear Information System (INIS)

    Tanaka, Tokutaro; Shimoyama, Ichiro; Endoh, Mitsutoshi; Ninchoji, Toshiaki; Uemura, Kenichi.

    1984-01-01

    The diagnosis of basal skull fractures used to be difficult, particularly on the basis of routine skull roentgenography alone. We have now examined the diagnostic value of conventional computerized tomography in basal skull fractures. We studied 82 cases clinically diagnosed as basal skull fractures. We examined them based on at least one of the following computerized tomographic criteria for basal skull fractures: 1) fracture line(s), 2) intracranial air, 3) fluid in the paranasal sinuses, and 4) fluid in the middle ear, including the mastoid air cells. The signs of the fracture line and of the intracranial air are definite indications of basal skull fracture, but the signs of fluid in the paranasal sinuses and/or in the middle ear are not definite. When combined, however, with such other clinical signs as black eye, Battle's sign, CSF leakage, CSF findings, and profuse nasal or ear bleeding, the diagnosis is more reliable. Seventy cases (85.4%) in this series had basal skull fractures according to our computerized tomographic criteria. Among them , 26 cases (31.7%) were diagnosed with fracture lines, 17 cases (20.7%) with intracranial air, 16 cases (19.5%) with fluid in the paranasal sinuses, 10 cases (12.2%) with fluid in the middle ear, and one case (1.2%) with fluid in both. Twelve cases (14.6%) of the 82 cases clinically diagnosed as basal skull fractures could not have been diagnosed on our computerized tomographic criteria alone. We diagnosed them because of CSF leakage, CSF findings, surgical findings, etc. (author)

  12. Computerized materials protection, control, and accountability

    International Nuclear Information System (INIS)

    Whiteson, R.; Seitz, S.; Landry, R.P.; Hadden, M.L.; Painter, J.A.

    1997-01-01

    The proliferation of nuclear weapons, along with the technical knowledge and materials needed to make these weapons, is an enduring problem of international urgency. Current international nuclear nonproliferation efforts are aimed at deterring, detecting, and responding to proliferation of weapons of mass destruction. These safeguards efforts are being implemented by applying preeminent science and technology to the management and control of nuclear materials. By strengthening systems of nuclear material protection, control, and accountability (MPC and A), one can reduce the threat of nuclear weapons proliferation. Two major programs of international cooperation are now underway to achieve this goal. The first is between the US Department of Energy (DOE) and the Institutes of the Russian Federation (Laboratory-to-Laboratory Program), and the second is between the US Government and Governments of the former Soviet Republics (Government-to-Government Program). As part of these programs, the DOE is working with facilities to assist them in implementing computerized MPC and A systems. This work is a collaboration between computer scientists and safeguards experts in both the US and the new Republics. The US is making available technology and expertise to enable Russian experts to build on computerized MPC and A software developed in the US. This paper describes the joint efforts of these international teams to develop sophisticated computerized MPC and A systems using modern computer hardware and software technology. These systems are being customized to meet the site-specific needs of each facility

  13. Computerized analysis of brain perfusion parameter images

    International Nuclear Information System (INIS)

    Turowski, B.; Haenggi, D.; Wittsack, H.J.; Beck, A.; Aurich, V.

    2007-01-01

    Purpose: The development of a computerized method which allows a direct quantitative comparison of perfusion parameters. The display should allow a clear direct comparison of brain perfusion parameters in different vascular territories and over the course of time. The analysis is intended to be the basis for further evaluation of cerebral vasospasm after subarachnoid hemorrhage (SAH). The method should permit early diagnosis of cerebral vasospasm. Materials and Methods: The Angiotux 2D-ECCET software was developed with a close cooperation between computer scientists and clinicians. Starting from parameter images of brain perfusion, the cortex was marked, segmented and assigned to definite vascular territories. The underlying values were averages for each segment and were displayed in a graph. If a follow-up was available, the mean values of the perfusion parameters were displayed in relation to time. The method was developed under consideration of CT perfusion values but is applicable for other methods of perfusion imaging. Results: Computerized analysis of brain perfusion parameter images allows an immediate comparison of these parameters and follow-up of mean values in a clear and concise manner. Values are related to definite vascular territories. The tabular output facilitates further statistic evaluations. The computerized analysis is precisely reproducible, i. e., repetitions result in exactly the same output. (orig.)

  14. Computerized management of plant intervention tasks

    International Nuclear Information System (INIS)

    Quoidbach, G.

    2004-01-01

    The main objective of the 'Computerized Management of Plant Intervention Tasks' is to help the staff of a nuclear or a conventional power plant or of any other complex industrial facility (chemical industries, refineries, and so on) in planning, organizing, and carrying out any (preventive or corrective) maintenance task. This 'Computerized Management of Plant Intervention Tasks' is organized around a data base of all plant components in the facility that might be subjected to maintenance or tagout. It allows to manage, by means of intelligent and configurable 'mail service', the course of the intervention requests as well as various treatments of those requests, in a safe and efficient way, adapted to each particular organization. The concept of 'Computerized Management' of plant intervention tasks was developed by BELGATOM in 1983 for the Belgian nuclear power plants of ELECTRABEL. A first implementation of this concept was made at that time for the Doel NPP under the name POPIT (Programming Of Plant Intervention Tasks). In 1988, it was decided to proceed to a functional upgrade of the application, using advanced software and hardware techniques and products, and to realize a second implementation in the Tihange NPP under the name ACM (Application Consignation Maintenance). (author)

  15. Diversity in computerized reactor protection systems

    International Nuclear Information System (INIS)

    Fischer, H.D.; Piel, L.

    1999-01-01

    Based on engineering judgement, the most important measures to increase the independency of redundant trains of a computerized safety instrumentation and control system (I and C) in a nuclear power plant are evaluated with respect to practical applications. This paper will contribute to an objective discussion on the necessary and justifiable arrangement of diversity in a computerized safety I and C system. Important conclusions are: - (i) diverse equipment may be used to control dependent failures only if measures necessary for designing, licensing, and operating a computerized safety I and C system homogeneous in equipment are neither technically nor economically feasible; - (ii) the considerable large operating experience in France with a non-diverse equipment digital reactor protection system does not call for equipment diversity. Although there are no generally accepted methods, the licensing authority is still required to take into account dependent failures in a probabilistic safety analysis; - (ii) the frequency of postulated initiating events implies which I and C functionality should be implemented on diverse equipment. Using non-safety I and C equipment in addition to safety I and C equipment is attractive because its necessary unavailability to control an initiating event in teamwork with the safety I and C equipment is estimated to range from 0.01 to 0.1. This can be achieved by operational experience

  16. Staging of bronchogenic carcinoma by computerized tomography

    International Nuclear Information System (INIS)

    Sommer, B.; Bauer, W.M.; Rath, M.; Fenzl, G.; Stelter, W.J.; Lissner, J.

    1981-01-01

    It was possible to check the information obtained by CT scanning in 36 patients out of 49 who had been subjected to computerized tomography, in respect of the extension of the primary tumour (T stage), and in 25 patients in respect of the degree of mediastinal lymphatic node involvement (N stage). In all 49 patients, the presence of bronchogenic carcinoma had been safely established. In 97% of the cases, assessment of the extension of the primary tumour was found to be correct. Assessment of the N stage, however, is more problematic, since detection of mediastinal lymphatic nodes by computerized tomography does not necessarily tell us something about their metastatic involvement. If all recognizable lymphatic nodes are interpreted as potential metastases, we have no false negative but 61% false positive results because of the frequency of postinflammatory or anthracotic lymphatic nodes. In case of exclusive assessment of lymphatic node enlargement above 1 cm diameter, the rate of metastatic nodes increases considerably (83%). Computerized tomography is definitely superior to all roentgenological methods in assessing the stage of a bronchogenic carcinoma; hence, it could occupy a key position in determining the diagnostic and therapeutic approach in patients with this disease. (orig.) [de

  17. Case of neurosarcoidosis monitored by computerized tomography

    Energy Technology Data Exchange (ETDEWEB)

    Kubota, T; Kimura, M; Komai, T; Yamamoto, S; Yamamura, I [Kanazawa Univ. (Japan). School of Medicine

    1979-12-01

    A 21-year-old man complaining of impaired visual acuity was admitted to the hospital. Physical examinations showed asymptomatic bilateral hilar lymphadenopathy and cardiomyopathy. Neurological findings disclosed left blindness and right temporal hemianopsia. Computerized tomography, pneumoencephalography and carotid angiography revealed a suprasellar mass. After the admission, the following symptoms deteriorated rapidly: diabetes insipidus, anterior pituitary dysfunction, visual loss of the right eye and hepatomegaly, subsequently consciousness disorder developed during a month though he was given steroids. The more deteriorated the clinical course, the larger the suprasellar mass with expanding hydrocephalus in repeated computerized tomographies. After the ventriculo-peritoneal shunt operation, consciousness improved. Diabetes insipidus also improved after Diabenese administration. On the operation, adhesive arachnoiditis over all the frontotemporal cortex and swollen purplishly red optic chiasm were exposed. Microscopically the specimen from the optic chiasm evidenced a sarcoid granuloma which composed of epitheroid cells, lymphocytes and multi-nucleated giant cells with numerous hemosiderin droplets. The specimen from the surface of the left frontal lobe showed thick fibrosis in the subarachnoid space. By steroids therapy, diabetes insipidus and hepatomegaly disappeared five months after the admission, whereas blindness never recovered. He died of developed status epilepticus eleven months after the admission. The authors reviewed neuroradiological findings of neurocarcoidosis based on pathological findings in the literature, and emphasized that computerized tomography was the most useful for diagnosis and treatment of neurosarcoidosis.

  18. Accelerated atherosclerosis in patients with systemic autoimmune diseases

    NARCIS (Netherlands)

    De Leeuw, K.; Kallenberg, Cees; Bijl, Marc; Shoenfeld, Y.; Gershwin, M.E.; Shoenfeld, Y; Gershwin, ME

    2005-01-01

    Systemic autoimmune diseases such as systemic lupus erythematosus and Wegener's granulomatosis are associated with a significantly increased prevalence of cardiovascular disease (CVD) compared with age- and sex-matched controls. Many risk factors are involved in the pathogenesis of atherosclerosis,

  19. Reproductive Health in Men and Women With Vasculitis

    Science.gov (United States)

    2014-06-25

    Giant Cell Arteritis; Takayasu's Arteritis; Polyarteritis Nodosa; Wegener's Granulomatosis; Microscopic Polyangiitis; Churg-Strauss Syndrome; Behcet's Disease; Kawasaki Disease; Henoch-schoenlein Purpura; Vasculitis, Central Nervous System; Drug-induced Necrotizing Vasculitis

  20. Pathogenesis of PR3-ANCA associated vasculitis

    NARCIS (Netherlands)

    Kallenberg, C. G. M.

    2008-01-01

    Wegener's Granulomatosis (WG) is closely associated with antineutrophil cytoplasmic autoantibodies (ANCA), particularly those directed to proteinase 3 (PR3). ANCA directed to myeloperoxidase (MPO) are associated with microscopic polyangiitis (MPA) and the Churg Strauss syndrome. PR3-ANCA associated

  1. Plasma exchange and glucocorticoid dosing in the treatment of anti-neutrophil cytoplasm antibody associated vasculitis (PEXIVAS)

    DEFF Research Database (Denmark)

    Walsh, Michael; Merkel, Peter A; Peh, Chen Au

    2013-01-01

    Granulomatosis with polyangiitis (GPA, Wegener's) and microscopic polyangiitis (MPA) are small vessel vasculitides collectively referred to as anti-neutrophil cytoplasm antibody-associated vasculitis (AAV). AAV is associated with high rates of morbidity and mortality due to uncontrolled disease...

  2. Pauci-immune necrotizing glomerulonephritis

    NARCIS (Netherlands)

    Rutgers, Abraham; Sanders, Jan S F; Stegeman, Coen A; Kallenberg, Cees G M

    Pauci-immune necrotizing glomerulonephritis is the most frequent cause of rapidly progressive glomerulonephritis and, in most cases, is associated with antineutrophil cytoplasmic antibodies (ANCA). It is either the renal manifestation of Wegener's granulomatosis, microscopic polyangiitis of

  3. Antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitis

    NARCIS (Netherlands)

    Kallenberg, Cees G. M.

    Purpose of reviews This review focuses on recent advance in the diagnosis pathogenesis and treatment of antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitis. Recent findings Antineutrophil cytoplasmic autoantibodies are closely associated with Wegener's granulomatosis and

  4. Brief Report

    DEFF Research Database (Denmark)

    Faurschou, Mikkel; Westman, Kerstin; Rasmussen, Niels

    2012-01-01

    The NORAM (Nonrenal Wegener's Granulomatosis Treated Alternatively with Methotrexate [MTX]) trial demonstrated that MTX can replace cyclophosphamide (CYC) as remission-inducing treatment for patients with newly diagnosed early systemic antineutrophil cytoplasmic antibody-associated vasculitis. Du...

  5. Ultrasonic and computerized tomographic semiotics of cholelithiasis

    International Nuclear Information System (INIS)

    Kishkovskij, A.N.; Kuznetsov, S.V.; Fadeev, V.D.

    1986-01-01

    Altogether 447 patients with suspected cholelithiasis were examined by means of routine X-ray methods, ultrasound (US) and computerized tomography (CT).Of them in 104 (23.3%) chole- and/or choledocholithiasis were later confirmed. An US and CT-picture of the biliferous tracts in health were described.In cholelithiasis during US examination echogenic concrements producing a stable acoustic shadow were defined in the gall bladder cavity and/or in the biliferous ducts. A study was made of the features of the US picture with relation to size, quantity, echodensity and grouping of concrements in the biliferous ducts. CT-symptomatology of cholelithiasis was described

  6. Computerized tomography in radiodiagnosis of pneumonia

    International Nuclear Information System (INIS)

    Degtyareva, I.A.; Mamaev, V.V.; Savchenko, A.P.

    1989-01-01

    Experience in the use of computerized tomography (CT) in combined radiodiagnosis of pneumonia was analysed. It has been concluded that CT objectively reflects morphological inflammatory changes and permits their all-round assessment over time. The diagnosis of pneumonia in CT is based on classical x-ray symptoms. As compared to survery radiography CT reveals symptoms of pneumonia to the full at earlier stages. CT is an important additional method of investigation of inflammatory pulmonary diseases but it should not be used separately without survey radiography. In a majority of cases when CT is performed there is no need in x-ray tomography

  7. Visualization in the age of computerization

    CERN Document Server

    Carusi, Annamaria; Webmoor, Timothy; Woolgar, Steve

    2014-01-01

    Digitalization and computerization are now pervasive in science. This has deep consequences for our understanding of scientific knowledge and of the scientific process, and challenges longstanding assumptions and traditional frameworks of thinking of scientific knowledge. Digital media and computational processes challenge our conception of the way in which perception and cognition work in science, of the objectivity of science, and the nature of scientific objects. They bring about new relationships between science, art and other visual media, and new ways of practicing science and organizing

  8. Development of a computerized tomographic system

    International Nuclear Information System (INIS)

    Borges, J.C.; Santos, C.A.C.

    1986-01-01

    The Nuclear Instrumentation Laboratory at COPPE/UFRJ has been developing techniques for detection and applications of nuclear radiations. A lot of research work has been done and resulted in several M.Sc. and D.Sc. thesis, concerning subjects like neutrongraphy, gammagraphy, image reconstruction, special detectors, etc. Recent progress and multiple applications of the computerized tomography to medical and industrial non-destructive tests, pushed the Laboratory to a vast program in this field of research. In this paper, we report what has been done and the results obtained. (Author) [pt

  9. Computerized tomography in diagnosis of cerebrocranial injury

    International Nuclear Information System (INIS)

    Kornienko, V.N.; Vasin, N.Ya.; Kuz'menko, V.A.

    1987-01-01

    The method of computerized tomographical examination are presented. Th KT-characters of concussion of the brain, its contusion of different severity, compressions in case of traumatic intracranial hematomas, contusion injuries, brain edema and different aftereffects of cerebrocranial injury are given. On the basis of comparison of the data of clinical and KT examination the dynamics of intracranial traumatic injuries in the course of treatment is described. The problems of therapeutic and surgical tactics depending on the degree and form of intracranial structure injuries and the phase of clinical course of posttraumatic process are discussed

  10. Computerized abdominal tomography in Wilson's disease

    Energy Technology Data Exchange (ETDEWEB)

    Tsuchikura, Keiko; Ogawa, Teruyuki; Nakajima, Akihisa; Ono, Yasuhiko

    1986-05-01

    Cranial and abdominal computerized tomography (CT) was performed in a 10-year-old boy with Wilson's disease complicated by liver cirrhosis. Abdominal CT showed diffuse high density areas over the whole part of the liver propably due to copper sediments, although there was no abnormal cranial CT findings. Decreased high density area of the liver was seen 60 days after the administration of D-penicillamine, suggesting the excretion of copper from the liver. Abdominal CT, as well as cranial CT, may be of help to diagnose Wilson's disease and evaluate therapeutic effects. (Namekawa, K.).

  11. Long-term patient survival in ANCA-associated vasculitis

    DEFF Research Database (Denmark)

    Flossmann, Oliver; Berden, Annelies; de Groot, Kirsten

    2011-01-01

    Wegener's granulomatosis and microscopic polyangiitis are antineutrophil cytoplasm antibodies (ANCA)-associated vasculitides with significant morbidity and mortality. The long-term survival of patients with ANCA associated vasculitis treated with current regimens is uncertain.......Wegener's granulomatosis and microscopic polyangiitis are antineutrophil cytoplasm antibodies (ANCA)-associated vasculitides with significant morbidity and mortality. The long-term survival of patients with ANCA associated vasculitis treated with current regimens is uncertain....

  12. [Biological treatment of rare inflammatory rheumatic diseases

    DEFF Research Database (Denmark)

    Baslund, B.

    2008-01-01

    The current status of the use of biological medicine in the treatment of adult onset morbus still, Wegeners granulomatosis and systemic lupus erythematosus (SLE) is reviewed. The need for controlled trials is emphasized. Anti-CD20 treatment for SLE patients with kidney involvement and patients wi...... with Wegeners granulomatosis seems promising. Anti-TNF and IL1 receptor antagonist can control disease activity in most patients with adult morbus still Udgivelsesdato: 2008/6/9...

  13. Biologisk behandling af sjaeldne inflammatoriske reumatiske sygdomme

    DEFF Research Database (Denmark)

    Baslund, Bo

    2008-01-01

    The current status of the use of biological medicine in the treatment of adult onset morbus still, Wegeners granulomatosis and systemic lupus erythematosus (SLE) is reviewed. The need for controlled trials is emphasized. Anti-CD20 treatment for SLE patients with kidney involvement and patients...... with Wegeners granulomatosis seems promising. Anti-TNF and IL1 receptor antagonist can control disease activity in most patients with adult morbus still....

  14. Modernizing computerized nuclear material accounting systems

    International Nuclear Information System (INIS)

    Erkkila, B.H.; Claborn, J.

    1995-01-01

    DOE Orders and draft orders for nuclear material control and accountability address a complete material control and accountability (MC and A) program for all DOE contractors processing, using, or storing nuclear materials. A critical element of an MC and A program is the accounting system used to track and record all inventories of nuclear material and movements of materials in those inventories. Most DOE facilities use computerized accounting systems to facilitate the task of accounting for all their inventory of nuclear materials. Many facilities still use a mixture of a manual paper system with a computerized system. Also, facilities may use multiple systems to support information needed for MC and A. For real-time accounting it is desirable to implement a single integrated data base management system for a variety of users. In addition to accountability needs, waste management, material management, and production operations must be supported. Information in these systems can also support criticality safety and other safety issues. Modern networked microcomputers provide extensive processing and reporting capabilities that single mainframe computer systems struggle with. This paper describes an approach being developed at Los Alamos to address these problems

  15. Patient surface doses in computerized tomography examinations

    International Nuclear Information System (INIS)

    Vekic, B; Kovacevic, S.; Ranogajec-Komor, M.; Duvnjak, N.; Marusic, P.; Anic, P.; Dolencic, P.

    1996-01-01

    The diagnostic value of computerized tomography has increased due to very rapid technical advances in both equipment and techniques. When the CT scanners were introduced, a significant problem for the specification of the radiation dose imparted to the patient undergoing CT examination has been created. In CT, the conditions of exposure are quite different from those in conventional X-ray imaging. CT procedure involves the continuous tomography of thin layers. Some of these layers touch each other while others overlap. The radiation doses received by patients can vary considerably. In addition to the radiation from the collimated primary beam, patients are exposed to significant scattered doses in unpredictable amounts. Every effort should be made to keep these doses to a reasonable minimum, without sacrificing the image quality. The aims of this work were to determine the surface doses delivered to various organs of patients during various computerized tomography examinations (head, thorax, kidney, abdomen and pelvis). Particular attention was directed to the precise determination of doses received by the eyes (during CT of head) and gonads (during CT of pelvis and lower abdomen) since these organs can be near or even in the primary X-ray beam

  16. Computerized tomographic in non-destructive testing

    International Nuclear Information System (INIS)

    Lopes, R.T.

    1988-01-01

    The process of computerized tomography has been developed for medical imaging purposes using tomographs with X-ray, and little attention has been given to others possibles applications of technique, because of its cost. As an alternative for the problem, we constructed a Tomographic System (STAC-1), using gamma-rays, for nonmedical applications. In this work we summarize the basic theory of reconstructing images using computerized tomography and we describe the considerations leading to the development of the experimental system. The method of reconstruction image implanted in the system is the filtered backprojection or convolution, with a digital filters system to carried on a pre-filtering in the projections. The experimental system is described, with details of control and the data processing. An alternative and a complementary system, using film as a detector is shown in preliminary form . This thesis discuss and shows the theorical and practical aspects, considered in the construction of the STAC-1, and also its limitations and apllications [pt

  17. A prototype of a computerized patient record.

    Science.gov (United States)

    Adelhard, K; Eckel, R; Hölzel, D; Tretter, W

    1995-01-01

    Computerized medical record systems (CPRS) should present user and problem oriented views of the patient file. Problem lists, clinical course, medication profiles and results of examinations have to be recorded in a computerized patient record. Patient review screens should give a synopsis of the patient data to inform whenever the patient record is opened. Several different types of data have to be stored in a patient record. Qualitative and quantitative measurements, narratives and images are such examples. Therefore, a CPR must also be able to handle these different data types. New methods and concepts appear frequently in medicine. Thus a CPRS must be flexible enough to cope with coming demands. We developed a prototype of a computer based patient record with a graphical user interface on a SUN workstation. The basis of the system are a dynamic data dictionary, an interpreter language and a large set of basic functions. This approach gives optimal flexibility to the system. A lot of different data types are already supported. Extensions are easily possible. There is also almost no limit concerning the number of medical concepts that can be handled by our prototype. Several applications were built on this platform. Some of them are presented to exemplify the patient and problem oriented handling of the CPR.

  18. Serum, liver, and lung levels of the major extracellular matrix components at the early stage of BCG-induced granulomatosis depending on the infection route.

    Science.gov (United States)

    Kim, L B; Shkurupy, V A; Putyatina, A N

    2015-01-01

    Experiments on the model of mouse BCG-induced granulomatous showed that the content of glycosaminoglycans and proteoglycans in the extracellular matrix of the liver and lungs are changed at the early stages of inflammation (days 3 and 30 postinfection) before cell destruction in the organs begins. This is related to degradation of extracellular matrix structures. Their high content in the blood and interstitium probably contributes to the formation of granulomas, fibroblast proliferation and organ fibrosis. These processes depend on the infection route that determines different conditions for generalization of the inflammation process. Intravenous method of vaccine injection is preferable to use when designing the experiments simulating tuberculosis granulomatosis, especially for the analysis of its early stages.

  19. Development of eosinophilic granulomatosis with poliangiitis (Churg-Strauss syndrome) and brain tumor in a patient after more than 7 years of omalizumab use: A case report.

    Science.gov (United States)

    Borekci, S; Aydin, O; Hatemi, G; Gemicioglu, B

    2015-03-01

    Omalizumab is a monoclonal anti-immunoglobulin E antibody used for the treatment of severe perennial allergic asthma. Previous reports have suggested that omalizumab treatment can be associated with the development of eosinophilic granulomatosis with poliangiitis (EGPA) (formerly known as Churg-Strauss syndrome) and an increased risk of malignancy. Long-term risks of omalizumab treatment are not very well defined. Here, we report the case of a 75-year-old woman with concurrent occurrence of EGPA and brain tumor after more than 7 years of omalizumab treatment. The possibility of EGPA should be borne in mind during long-term treatment with omalizumab. Despite the absence of definitive data, an association may also exist between the development of malignancy and omalizumab use. © The Author(s) 2015.

  20. Lymphomatoid granulomatosis of central nervous system and lung driven by epstein barr virus proliferation: successful treatment with rituximab-containing chemotherapy.

    Science.gov (United States)

    Fernandez-Alvarez, Ruben; Gonzalez, Me; Fernandez, Almudena; Gonzalez-Rodriguez, Ap; Sancho, Jm; Dominguez, Francisco; Fernandez, Carmen

    2014-01-01

    Lymphomatoid granulomatosis (LYG) is a very rare Epstein-Barr virus (EBV) associated B-cell lymphoproliferative disorder. We report the case of a 41-year-old man who presented with fever and respiratory symptoms. Computed tomography showed multiple nodules in both lung fields. Polymerase chain reaction (PCR) analysis for EBV was positive in bronchoalveolar lavage and biopsy of lung node yielded a diagnosis of LYG, grade III. Shortly after initiation of treatment with agressive chemotherapy, neurological deterioration appeared. Neuroimaging findings revealed hydrocephalus and PCR analysis of the cerebrospinal fluid (CSF) was positive for EBV. Treatment with intravenous rituximab led to rapid reduction of EBV load in CSF, along with clinical and radiological improvement. After completion of treatment with immunochemotherapy, an autologous stem cell transplantation was performed. Patient stays in remission 18 months after diagnosis.

  1. Radiographic analysis of body composition by computerized axial tomography

    International Nuclear Information System (INIS)

    Heymsfield, S.B.

    1986-01-01

    Radiographic methods of evaluating body composition have been applied for over five decades. A marked improvement in this approach occurred in the mid-nineteen-seventies with the introduction of computerized axial tomography. High image contrast, cross-sectional imaging and rapid computerized data processing make this technique a sophisticated clinically applicable tool. (author)

  2. Direct coronary and sagittal computerized tomography of the pelvis

    International Nuclear Information System (INIS)

    Maier, W.; Bargon, G.

    1981-01-01

    Whereas quite a number of reports have been published on direct coronary and sagittal computed tomography of the cranium, no extensive experience has been collected on multidimensional computerized tomography of the pelvis. In this article, the authors report on their preliminary experiences in direct approximately sagittal and coronary computerized tomography of the pelvis in a group of 76 patients. (orig.) [de

  3. Computerized tomography in evaluation of the pulmonary hilum

    International Nuclear Information System (INIS)

    Secaf, M.; Ferreira, J.L.N.; Secaf, E.

    1987-01-01

    The use of computerized tomography as a method for evaluating the pulmonary hilum and its application in the diagnosis of endobronchial lesions, hilar masss, contiguous involvement of the mediastinum by hilar mass, and vascular hilar lesions are discussed. A comparative evaluation between conventional tomograms and computerized tomography is presented. (M.A.C.) [pt

  4. Pembrolizumab reactivates pulmonary granulomatosis

    Directory of Open Access Journals (Sweden)

    Majdi Al-dliw

    2017-01-01

    Full Text Available Sarcoid like reaction is a well-known entity that occurs as a consequence to several malignancies or their therapies. Immunotherapy has gained a lot of interest in the past few years and has recently gained approval as first line therapy in multiple advanced stage malignancies. Pneumonitis has been described as complication of such therapy. Granulomatous inflammation has been only rarely reported subsequent to immunotherapy. We describe a case of granulomatous inflammation reactivation affecting the lungs in a patient previously exposed to Pembrolizumab and have evidence of a distant granulomatous infection. We discuss potential mechanisms of the inflammation and assert the importance of immunosuppression in controlling the dis-inhibited immune system.

  5. Granulomatosis with polyangiitis

    Science.gov (United States)

    ... ncbi.nlm.nih.gov/pubmed/21372195 . Specks U, Merkel PA, Seo P, et al. Efficacy of remission- ... PA: Elsevier Saunders; 2016:chap 270. Stone JH, Merkel PA, Spiera R, et al. Rituximab versus cyclophosphamide ...

  6. A COMPUTERIZED OPERATOR SUPPORT SYSTEM PROTOTYPE

    Energy Technology Data Exchange (ETDEWEB)

    Thomas A. Ulrich; Roger Lew; Ronald L. Boring; Ken Thomas

    2015-03-01

    A computerized operator support system (COSS) is proposed for use in nuclear power plants to assist control room operators in addressing time-critical plant upsets. A COSS is a collection of technologies to assist operators in monitoring overall plant performance and making timely, informed decisions on appropriate control actions for the projected plant condition. A prototype COSS was developed in order to demonstrate the concept and provide a test bed for further research. The prototype is based on four underlying elements consisting of a digital alarm system, computer-based procedures, piping and instrumentation diagram system representations, and a recommender module for mitigation actions. The initial version of the prototype is now operational at the Idaho National Laboratory using the Human System Simulation Laboratory.

  7. Computerized accountability program is operating - DYMCAS

    International Nuclear Information System (INIS)

    Combs, S.W.; Mee, W.T.

    1983-01-01

    The nuclear materials control and accountability program in the Oak Ridge Y-12 Plant has been placed on a computerized system identified as DYMCAS (Dynamic Special Nuclear Materials Control and Accountability System). The primary gola of the DYMCAS is to assist in detecting the diversion of special nuclear material (SNM). Secondly, the system is expected to assure quality inventory reconciliations both under normal and emergency situations. The system has been installed and was placed on active status in April 1982. Since that time numerous problems have surfaced and been resolved; i.e., delays of input, hardware breakdown, and misunderstandings of needs. An explanation of these problems, including examples and alterations that have made the system workable, are presented

  8. A computerized accountability program is operating - DYMCAS

    International Nuclear Information System (INIS)

    Combs, S.W.; Mee, W.T.

    1983-01-01

    The nuclear materials control and accountability program in the Oak Ridge Y-12 Plant has been placed on a computerized system identified as DYMCAS (Dynamic Special Nuclear Materials Control and Accountability System). The primary goal of the DYMCAS is to assist in detecting the diversion of special nuclear material (SNM). Secondly, the system is expected to assure quality inventory reconciliations both under normal and emergency situations. The system has been installed and was placed on active status in April 1982. Since that time numerous problems have surfaced and been resolved; i.e., delays of input, hardware breakdown, and misunderstandings of needs. An explanation of these problems, including examples and alterations that have made the system workable, are presented

  9. Computerized tomographic scanner with shaped radiation filter

    International Nuclear Information System (INIS)

    Carlson, R.W.; Walters, R.G.

    1981-01-01

    The invention comprises a shaped filter and a filter correction circuitry for computerized tomographic scanners. The shaped filter is a generally u-shaped block of filter material which is adapted to be mounted between the source of radiation and the scan circle. The u-shaped block has a parabolic recess. The filter material may be beryllium, aluminum, sulphur, calcium, titanium, erbium, copper, and compounds including oxides and alloys thereof. The filter correction circuit comprises a first filter correction profile adding circuit for adding a first scaler valve to each intensity valve in a data line. The data line is operated on by a beam hardness correction polynomial. After the beam hardness polynomial correction operation, a second filter correction circuit adds a second filter correction profile consisting of a table of scalor values, one corresponding to each intensity reading in the data line

  10. Computerized tomography findings in nasolacrimal dysfunction

    International Nuclear Information System (INIS)

    Ishida, Toshio; Nakamura, Yasuhisa; Kumagai, Michiasa

    1985-01-01

    We examined 17 cases (22 lesions) with stenosis or obstruction in the lacrimal drainage system with the use of computerized tomography (CT). In idio pathic cases, the site of obstruction was located either in the upper nasolacrimal duct or at the junction of the lacrimal sac and the nasolacrimal duct. In post-traumatic cases, it was located in the lower nasolacrimal duct. The obstructed areas appeared as homogenous in CT image with CT values ranging between +60 and +80. These findings were suggestive of granulation tissue. The stenosed areas appeared, on the other hand, as areas of unequal density. Lacrimal passage appeared to be maintained through the low-density portion. The CT values of the lacrimal sac was around +40 in dacryocystitis and around +20 to +30 other cases. (author)

  11. Organ doses from computerized tomography examinations

    Energy Technology Data Exchange (ETDEWEB)

    Janeczek, J.

    1995-12-31

    Estimates of mean organs doses from five typical computerized tomography (CT) examinations were obtained. Measurements were done using Rando-Alderson anthropomorphic phantom and thermoluminescent dosemeters (TLD). Radiation dose distributions within a phantom has been measured for each examination and results were used for organ dose calculation. Doses to organs specified by ICPR 60 Recommendations were measured for five CT scanners (CT/T8800, CT 9800, CT MAX - made by General Electric; CT 1200 SX - made by Picker; SOMATOM 2 - made by Siemens). Dose distributions from scattered radiation were measured and indicate that scattered radiation dose to thyroid and eye lens can be reduced by proper examination limits setting. The lowest mean organ doses were obtained from CT/T8800 scanner. More advanced scanners using high intensity continuous radiation were giving higher organ doses. (author). 23 refs, 6 figs, 13 tabs.

  12. Computerized techniques for collecting the radioprotection data

    International Nuclear Information System (INIS)

    Cenusa, V.; Valeca, S.; Guta, C.; Talpalariu, C.; Stoica, V.

    2016-01-01

    An important component of a computerized radioprotection system is the module for the collection of the radioprotection data. The data collection can be made automatically from the measurement equipment or manually by the operators after they read the values measured by the mobile devices. Database systems are used for storing the data, they offer higher performances, more efficient data organization, ensure data integrity and controlled access to the data into a multiuser environment. The experimental program for the automatic collection of the remote data transfers periodically, at programmable time intervals, data files from the fixed radiation monitoring stations to a centralized system for radioprotection data. For this is used the File Transfer Protocol (FTP). A Radiation Monitoring Equipment designed and assembled in the Electronics Department of ICN Pitesti was used as a data source for the testing of the experimental programs. (authors)

  13. Computerization of a telescope at secondary education

    Science.gov (United States)

    García Santiago, A.; Martos Jumillas, J.

    2017-03-01

    The work we are presenting in this paper is the computerization of a refractor telescope on an EQ3 type equatorial mount through Arduino. The control of the mount is done via three different interfaces: Stellarium, an Android interface for mobile phones and a second interface for PC made with Processing. The aforementioned work was done by the authors with a double purpose: presenting the interest in astronomy in the Mathematics department, and the development of applications within the subject of Technology in 4th ESO. So, it is a collaborative project between both departments. Except for the telescope and the mount, all the resources we have used can be found in any high school: free software (Guadalinex v9), App Inventor and Processing.The project was carried out under the principle of reducing all possible costs given the economic possibilities of the institution.

  14. Development of computerized risk management tool

    International Nuclear Information System (INIS)

    Kil Yoo Kim; Mee Jung Hwang; Seung Cheol Jang; Sang Hoon Han; Tae Woon Kim

    1997-01-01

    The author describes the kinds of efforts for the development of computerized risk management tool; (1) development of a risk monitor, Risk Monster, (2) improvement of McFarm (Missing Cutsets Finding Algorithm for Risk Monitor) and finally (3) development of reliability database management system, KwDBMan. Risk Monster supports for plant operators and maintenance schedulers to monitor plant risk and to avoid high peak risk by rearranging maintenance work schedule. Improved McFarm significantly improved calculation speed of Risk Monster for the cases of supporting system OOS (Out Of Service). KwDBMan manages event data, generic data and CCF (Common Cause Failure) data to support Risk Monster as well as PSA tool, KIRAP (KAERI Integrated Reliability Analysis Package)

  15. Computerized tomographic evaluation of cerebral cysticercosis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bo Young; Lee, Mi Sook; Jeon, Doo Sung; Kim, Hong Soo; Rhee, Hak Song [Precbyterian Medical Center, Chonju (Korea, Republic of)

    1988-08-15

    Cerebral cysticercosis, unfortunately frequent in Korea, is a parastic disease in which man serve as the intermediate host of taenia solium. The larvae have a predilection for the central nervous system and can cause a variety of neurologic symptoms. The authors reviewed 19 cases of surgically proven cerebral cysticercosis and following results were obtained. 1. The most frequent age distribution was 5th and 6th decade and male to female ratio was 14:5. 2. The most frevalent involving site was cerebral parenchyme and following by ventricles. 3. Clinical manifestations were symtom and sign of increased ICP, seizure and focal neurological dificit. 4. It was assumed that computerized tomography was the procedure of choice for the diagnosis of these parasitic brain disease.

  16. Computerized axial tomography in traumatic cervical lesions

    International Nuclear Information System (INIS)

    Koyama, Tsunemaro

    1982-01-01

    Although plain computerized axial tomography cannot routinely demonstrate the spinal cord, it does provide excellent visualization of the bony outline of the spinal canal and vertebral column. So it should be reasonable to use this technique in cases of cervical traumatic disorders. In this paper we presented 10 cases of cervical traumatic lesions; 3 atlanto-axial dislocation, 2 cervical canal stenosis, 3 OPLL, 1 intramedullary hematoma and 1 C 2 -neurinoma. In some patients neurologic deficits were induced by cervical trauma. Bony lesions appeared more adequately deliniated than intraspinal lesions, however, in some cases intramedullary changes could also be demonstrated. The use of metrizamide with high resolution CT-scanner could improve the usefullness of this technique. (author)

  17. Organ doses from computerized tomography examinations

    International Nuclear Information System (INIS)

    Janeczek, J.

    1995-01-01

    Estimates of mean organs doses from five typical computerized tomography (CT) examinations were obtained. Measurements were done using Rando-Alderson anthropomorphic phantom and thermoluminescent dosemeters (TLD). Radiation dose distributions within a phantom has been measured for each examination and results were used for organ dose calculation. Doses to organs specified by ICPR 60 Recommendations were measured for five CT scanners (CT/T8800, CT 9800, CT MAX - made by General Electric; CT 1200 SX - made by Picker; SOMATOM 2 - made by Siemens). Dose distributions from scattered radiation were measured and indicate that scattered radiation dose to thyroid and eye lens can be reduced by proper examination limits setting. The lowest mean organ doses were obtained from CT/T8800 scanner. More advanced scanners using high intensity continuous radiation were giving higher organ doses. (author). 23 refs, 6 figs, 13 tabs

  18. Dose evaluation in diagnostic for computerized tomography

    International Nuclear Information System (INIS)

    Flores, W.; Borges, J.C.; Mota, H.

    1998-01-01

    The patients which are subjected to computerized tomography tests are exposed to relatively high doses given as result doses on organs that are not matter to test. It was realized a dose levels raising in patients subjected to tests by T C, utilizing to measure this magnitude, TLD-100 thermoluminescent dosemeters which were put directly on the patient, in eye regions, thyroid, breast and navel; founding doses fluctuating between 29.10-49.39 mGy in organs examined and dose values between 0.21-29.10 mGy for organs that no matter to test. The applications of ionizing radiations in medicine do not have dose limits, but paying attention to the radiological protection optimization principle, it is recommended the use of clothes to anti-rays protection for zones not examined, getting with this to reduce the level doses as low as possible, without this to diminish the test quality. (Author)

  19. Computerized information management for institutional review boards.

    Science.gov (United States)

    Hood, Maureen N; Gugerty, Brian; Levine, Richard; Ho, Vincent B

    2005-01-01

    The use of human subjects for medical research in most industrialized nations requires the scientific and ethical scrutiny of research proposals by a governing institutional review board (IRB) or its equivalent. As part of their primary charge to protect human subjects, IRBs are responsible for the regulatory oversight of not only the research protocol itself but also the research conduct of the investigators and, if applicable, the funding sponsor. This article will discuss the regulatory requirements for an accurate account of IRB protocols and investigators and present an overview of the general flow of information for an IRB protocol. The current and potential uses of information management systems by IRBs will also be reviewed and accompanied by a discussion of the potential advantages and disadvantages of various computerized information systems for management of clinical research.

  20. Normal anatomical measurements in cervical computerized tomography

    International Nuclear Information System (INIS)

    Zaunbauer, W.; Daepp, S.; Haertel, M.

    1985-01-01

    Radiodiagnostically relevant normal values and variations for measurements of the cervical region, the arithmetical average and the standard deviation were determined from adequate computer tomograms on 60 healthy women and men, aged 20 to 83 years. The sagittal diameter of the prevertebral soft tissue and the lumina of the upper respiratory tract were evaluated at exactly defined levels between the hyoid bone and the incisura jugularis sterni. - The thickness of the aryepiglottic folds, the maximal sagittal and transverse diameters of the thyroid gland and the calibre of the great cervical vessels were defined. - To assess information about laryngeal function in computerized tomography, measurements of distances between the cervical spine and anatomical fixed points of the larynx and hypopharynx were made as well as of the degree of vocal cord movement during normal respiration and phonation. (orig.) [de

  1. Computerized radionuclidic analysis in production facilities

    International Nuclear Information System (INIS)

    Gibbs, A.

    1978-03-01

    The Savannah River Plant Laboratories Department has been using a dual computer system to control all radionuclidic pulse height analyses since 1971. This computerized system analyzes 7000 to 8000 samples per month and has allowed the counting room staff to be reduced from three persons to one person. More reliable process information is being returned to the production facilities and for environmental evaluations and being returned faster, even though the sample load has more than tripled. This information is now more easily retrievable for other evaluations. The computer is also used for mass spectrometer data reduction and for quality control data analysis. The basic system is being expanded by interfacing microcomputers which provide data input from all of the laboratory modules for quality assurance programs

  2. Termination Criteria for Computerized Classification Testing

    Directory of Open Access Journals (Sweden)

    Nathan A. Thompson

    2011-02-01

    Full Text Available Computerized classification testing (CCT is an approach to designing tests with intelligent algorithms, similar to adaptive testing, but specifically designed for the purpose of classifying examinees into categories such as - pass- and - fail.- Like adaptive testing for point estimation of ability, the key component is the termination criterion, namely the algorithm that decides whether to classify the examinee and end the test or to continue and administer another item. This paper applies a newly suggested termination criterion, the generalized likelihood ratio (GLR, to CCT. It also explores the role of the indifference region in the specification of likelihood-ratio based termination criteria, comparing the GLR to the sequential probability ratio test. Results from simulation studies suggest that the GLR is always at least as efficient as existing methods.

  3. Computerized Clinical Decision Support: Contributions from 2015

    Science.gov (United States)

    Bouaud, J.

    2016-01-01

    Summary Objective To summarize recent research and select the best papers published in 2015 in the field of computerized clinical decision support for the Decision Support section of the IMIA yearbook. Method A literature review was performed by searching two bibliographic databases for papers related to clinical decision support systems (CDSSs) and computerized provider order entry (CPOE) systems. The aim was to identify a list of candidate best papers from the retrieved papers that were then peer-reviewed by external reviewers. A consensus meeting between the two section editors and the IMIA editorial team was finally conducted to conclude in the best paper selection. Results Among the 974 retrieved papers, the entire review process resulted in the selection of four best papers. One paper reports on a CDSS routinely applied in pediatrics for more than 10 years, relying on adaptations of the Arden Syntax. Another paper assessed the acceptability and feasibility of an important CPOE evaluation tool in hospitals outside the US where it was developed. The third paper is a systematic, qualitative review, concerning usability flaws of medication-related alerting functions, providing an important evidence-based, methodological contribution in the domain of CDSS design and development in general. Lastly, the fourth paper describes a study quantifying the effect of a complex, continuous-care, guideline-based CDSS on the correctness and completeness of clinicians’ decisions. Conclusions While there are notable examples of routinely used decision support systems, this 2015 review on CDSSs and CPOE systems still shows that, despite methodological contributions, theoretical frameworks, and prototype developments, these technologies are not yet widely spread (at least with their full functionalities) in routine clinical practice. Further research, testing, evaluation, and training are still needed for these tools to be adopted in clinical practice and, ultimately, illustrate

  4. Diagnostics of neuromuscular diseases with the aid of computerized tomography

    Energy Technology Data Exchange (ETDEWEB)

    Visser, M de; Verbeeten, Jr, B J

    1988-06-04

    In this article the diagnosis of neuromuscular diseases with the aid of computerized tomography is treated. Computerized tomography of skeletal muscles give no information which is pathognomonic for particular diseases. But the technique can be used in the following aspects: to choose a muscle for a biopsy; when it is not possible to examine the function of a muscle, a CT scan can visualize morphological deviations; in the differentiation of muscle hypertrophy and pseudo-hypertrophy. For some cases as Becker-type muscular dystrophy, facioscapulohumeral dystrophy and Kugelberg-Welander type spinal muscular atrophy computerized tomography gives characteristic images. 10 refs.; 6 figs.

  5. Diagnostics of neuromuscular diseases with the aid of computerized tomography

    International Nuclear Information System (INIS)

    Visser, M. de; Verbeeten, B.J. Jr.

    1988-01-01

    In this article the diagnosis of neuromuscular diseases with the aid of computerized tomography is treated. Computerized tomography of skeletal muscles give no information which is pathognomonic for particular diseases. But the technique can be used in the following aspects: to choose a muscle for a biopsy; when it is not possible to examine the function of a muscle, a CT scan can visualize morphological deviations; in the differentiation of muscle hypertrophy and pseudo-hypertrophy. For some cases as Becker-type muscular dystrophy, facioscapulohumeral dystrophy and Kugelberg-Welander type spinal muscular atrophy computerized tomography gives characteristic images. 10 refs.; 6 figs

  6. Results of CT brain examinations in cerebrovascular emergency. [computerized tomography

    Energy Technology Data Exchange (ETDEWEB)

    Pinta, Z; Dolansky, J; Sorfova, J; Jerie, T

    1987-07-01

    Experience is briefly reported with CT (computerized tomography) diagnosis of cerebrovascular emergencies. It is pointed out that the introduction of computerized tomography greatly improved and made more accurate the diagnosis of focal ischemias and revealed significant differences in the foci of ischemia in hypertension patients and atherosclerosis patients without hypertension, and showed a higher incidence of intracerebral and subarachnoidal hemorrhages than previously thought. It is believed that knowledge gained thanks to CT (computerized tomography) will be of benefit to the primary and secondary prevention of cerebrovascular ischemias. (L.O.). 1 fig., 5 refs.

  7. Research on accounting transition from computerization to informationization

    Directory of Open Access Journals (Sweden)

    Shu Chen

    2017-11-01

    Full Text Available The application for computer technology, digitalization technology and network technology in the accounting field has promoted the development of accounting informationization. Accounting informationization is a product integrated with traditional accounting theory and modern information technology, which is an inevitable trend of continuous development of modern accounting. This paper discusses the basic concepts and characteristics of accounting computerization and informationization based on the normative research method and literature data method, analyzes the feasibility of accounting transition from computerization to informationization, and finally puts forward the specific approaches and ultimate goals of accounting transition from computerization to informationization.

  8. Representation of Arctic mixed-phase clouds and the Wegener-Bergeron-Findeisen process in climate models: Perspectives from a cloud-resolving study

    Science.gov (United States)

    Fan, Jiwen; Ghan, Steven; Ovchinnikov, Mikhail; Liu, Xiaohong; Rasch, Philip J.; Korolev, Alexei

    2011-01-01

    Two types of Arctic mixed-phase clouds observed during the ISDAC and M-PACE field campaigns are simulated using a 3-dimensional cloud-resolving model (CRM) with size-resolved cloud microphysics. The modeled cloud properties agree reasonably well with aircraft measurements and surface-based retrievals. Cloud properties such as the probability density function (PDF) of vertical velocity (w), cloud liquid and ice, regimes of cloud particle growth, including the Wegener-Bergeron-Findeisen (WBF) process, and the relationships among properties/processes in mixed-phase clouds are examined to gain insights for improving their representation in General Circulation Models (GCMs). The PDF of the simulated w is well represented by a Gaussian function, validating, at least for arctic clouds, the subgrid treatment used in GCMs. The PDFs of liquid and ice water contents can be approximated by Gamma functions, and a Gaussian function can describe the total water distribution, but a fixed variance assumption should be avoided in both cases. The CRM results support the assumption frequently used in GCMs that mixed phase clouds maintain water vapor near liquid saturation. Thus, ice continues to grow throughout the stratiform cloud but the WBF process occurs in about 50% of cloud volume where liquid and ice co-exist, predominantly in downdrafts. In updrafts, liquid and ice particles grow simultaneously. The relationship between the ice depositional growth rate and cloud ice strongly depends on the capacitance of ice particles. The simplified size-independent capacitance of ice particles used in GCMs could lead to large deviations in ice depositional growth.

  9. Computerized data base of the fundamental constants of nature

    International Nuclear Information System (INIS)

    Henry, E.A.; Hampel, V.E.

    1975-01-01

    Fifty-seven fundamental constants of nature were computerized from the up-to-date evaluations of E. R. Cohen and B. N. Taylor. The constants are annotated with regard to symbol, value, uncertainty, and scaling factor. This computerization is part of the scientific data base project of the Information Research Group at Lawrence Livermore Laboratory. The MASTER CONTROL data base management system is used. The computerized fundamental constants can be requested from the ERDA Computer Program Exchange and Information Center of the Argonne National Laboratory or from the National Technical Information Service of the U. S. Department of Commerce. This is the first of a series of releases on preparation of computerized scientific and technological data banks. The next release is a data bank of conversion factors for different units of measurements. 3 figures

  10. Cranial computerized tomography in children suffering from acute leukemia

    International Nuclear Information System (INIS)

    Metz, O.

    1981-01-01

    Cranial computerized (axial) tomography permits a more complete neurologic supervision of children with acute leukemia and a better knowledge of the frequency and varieties of cerebral complications in leukemia. Endocranial complications in acute leukemia are essentially infiltrative, hemorrhagic, infectious or iatrogenic. Cranial computerized tomography can demonstrate cerebral changes in meningeal leukemia, hemorrhages, calcifications, brain atrophy or leukencephalopathy. The preliminary results of cranial computerized tomography in childhood leukemia suggest that the iatrogenic main lesion of the brain due to combined radiation-chemotherapy is atrophy whereas that of the intrathecal cytostatic therapy is demyelination. Accurate diagnostics and control of possible cerebral complications in therapy of leukemia is essentially for appropriate therapeutic management. For that cranial computerized tomography is the best method to a effective supervision of the brain. (author)

  11. Computerized Point of Sale = Faster Service + Better Accountability.

    Science.gov (United States)

    Pannell, Dorothy V.

    1991-01-01

    Describes selecting and installing a computerized point of sale for a district food service program; the equipment needed and preferred; and the training of trainers, managers, and cashiers. Also discusses the direct benefits and side benefits of the system. (MLF)

  12. 381 Developing of a Computerized Brain Diagnosing System for ...

    African Journals Online (AJOL)

    User

    Ogunsanwo O. D. - Department of Computer Science, Gate way ICT ... computerized brain diagnosing system that would be used in carrying out the ..... This aspect explores the techniques use for the design of interface, menus and databases ...

  13. Computerized Tomography and its Applications : a Guided Tour

    NARCIS (Netherlands)

    Roerdink, J.B.T.M.

    1992-01-01

    We present a review of the mathematical principles of computerized tomography. Topics treated include the role of the Radon transform and related transforms, inversion formulas, uniqueness, ill-posedness and stability, practical reconstruction algorithms, and various generalizations such as

  14. Algorithmic fundamentals of computerized tomography and of transverse analogue tomography

    International Nuclear Information System (INIS)

    Heckmann, K.

    1981-01-01

    Computerized tomography and transverse analogue tomography are two different approaches to the same goal, namely, transverse tomography. The algorithm is discussed and compared. Transverse tomography appears capable of further development, judging by this comparison. (orig.) [de

  15. Survey of methods for improving operator acceptance of computerized aids

    International Nuclear Information System (INIS)

    Frey, P.R.; Kisner, R.A.

    1982-04-01

    The success of current attempts to improve the operational performance and safety of nuclear power plants by installing computerized operational aids in the control rooms is dependent, in part, on the operator's attitude toward the aid. Utility experience with process computer systems indicates that problems may already exist with operator acceptance of computerized aids. The growth of the role that computers have in nuclear power plants makes user acceptance of computer technology an important issue for the nuclear industry. The purpose of this report is to draw from the literature factors related to user acceptance of computerized equipment that may also be applicable to the acceptance of computerized aids used in the nuclear power plant control room

  16. Development of a computerized handbook of architectural plans

    NARCIS (Netherlands)

    Koutamanis, A.

    1990-01-01

    The dissertation investigates an approach to the development of visual / spatial computer representations for architectural purposes through the development of the computerized handbook of architectural plans (chap), a knowledge-based computer system capable of recognizing the metric properties of

  17. Survey of methods for improving operator acceptance of computerized aids

    Energy Technology Data Exchange (ETDEWEB)

    Frey, P. R.; Kisner, R. A.

    1982-04-01

    The success of current attempts to improve the operational performance and safety of nuclear power plants by installing computerized operational aids in the control rooms is dependent, in part, on the operator's attitude toward the aid. Utility experience with process computer systems indicates that problems may already exist with operator acceptance of computerized aids. The growth of the role that computers have in nuclear power plants makes user acceptance of computer technology an important issue for the nuclear industry. The purpose of this report is to draw from the literature factors related to user acceptance of computerized equipment that may also be applicable to the acceptance of computerized aids used in the nuclear power plant control room.

  18. Computerized tomographic evaluation of aortic prosthetic graft complications

    International Nuclear Information System (INIS)

    Kay, D.; Kalmar, J.A.

    1985-01-01

    Computerized tomography has been found to be an accurate and sensitive method of diagnosing complications of synthetic aortic grafts. Complications in this series of four cases included aortoesophageal fistula, aortoduodenal fistula, pseudoaneurysm, and retroperitoneal hematoma. 6 references, 5 figures

  19. Computerized Analysis and Detection of Missed Cancer in Screening Mammogram

    National Research Council Canada - National Science Library

    Li, Lihua

    2005-01-01

    This project is to explore an innovative CAD strategy for improving early detection of breast cancer in screening mammograms by focusing on computerized analysis and detection of cancers missed by radiologists...

  20. Computerized Analysis and Detection of Missed Cancer in Screening Mammogram

    National Research Council Canada - National Science Library

    Li, Lihua

    2004-01-01

    This project is to explore an innovative CAD strategy for improving early detection of breast cancer in screening mammograms by focusing on computerized analysis and detection of cancers missed by radiologists...

  1. Journal of EEA, Vol. 30, 2013 COMPUTERIZED FACILITIES ...

    African Journals Online (AJOL)

    dell

    Key words: Computer Aided Layout Design,. Construction ... Commonly used software are ... popular improvement-type methods are. Computerized Relative Allocation of Facilities .... closeness ratings values are given different numerical.

  2. Stratification of mammographic computerized analysis by BI-RADS categories

    Energy Technology Data Exchange (ETDEWEB)

    Lederman, Richard [Department of Radiology, Hadassah University Hospital, Ein Kerem, Jerusalem (Israel); Leichter, Isaac [Department of Electro-Optics, Jerusalem College of Technology, P.O.B. 16031, Jerusalem (Israel); Buchbinder, Shalom [Department of Radiology of The Montefiore Medical Center, The University Hospital for the Albert Einstein College of Medicine, Bronx, New York (United States); Novak, Boris [Department of Applied Mathematics, Jerusalem College of Technology, P.O.B. 16031, Jerusalem 91160 (Israel); Bamberger, Philippe [Department of Electronics, Jerusalem College of Technology, POB 16031, Jerusalem (Israel); Fields, Scott [Department of Radiology, Hadassah University Hospital, Mt. Scopus, Jerusalem (Israel)

    2003-02-01

    The Breast Imaging Reporting and Data System (BI-RADS) was implemented to standardize characterization of mammographic findings. The purpose of the present study was to evaluate in which BI-RADS categories the changes recommended by computerized mammographic analysis are most beneficial. Archival cases including, 170 masses (101 malignant, 69 benign) and 63 clusters of microcalcifications (MCs; 36 malignant, 27 benign), were evaluated retrospectively, using the BI-RADS categories, by several radiologists, blinded to the pathology results. A computerized system then automatically extracted from the digitized mammogram features characterizing mammographic lesions, which were used to classify the lesions. The results of the computerized classification scheme were compared, by receiver operating characteristics (ROC) analysis, to the conventional interpretation. In the ''low probability of malignancy group'' (excluding BI-RADS categories 4 and 5), computerized analysis improved the A{sub z}of the ROC curve significantly, from 0.57 to 0.89. In the ''high probability of malignancy group'' (mostly category 5) the computerized analysis yielded an ROC curve with an A {sub z}of 0.99. In the ''intermediate probability of malignancy group'' computerized analysis improved the A {sub z}significantly, from 0.66 for to 0.83. Pair-wise analysis showed that in the latter group the modifications resulting from computerized analysis were correct in 83% of cases. Computerized analysis has the ability to improve the performance of the radiologists exactly in the BI-RADS categories with the greatest difficulties in arriving at a correct diagnosis. It increased the performance significantly in the problematic group of ''intermediate probability of malignancy'' and pinpointed all the cases with missed cancers in the ''low probability'' group. (orig.)

  3. Computerized systems of NPP operators support. (Psychological problems)

    International Nuclear Information System (INIS)

    Mashin, V.A.

    1995-01-01

    Operator psychological problems arising in the work with NPP operators support computerized systems (OSCS) are considered. The conclusion is made that the OSCS intellectual application will bring the operator into dangerous dependence on his computerized assistant. To avoid this danger it is necessary by creation of the OSCS to divide specially the tasks areas of the operator and OSCS in order to assure the active role of the operator in the NPP control

  4. Stratification of mammographic computerized analysis by BI-RADS categories

    International Nuclear Information System (INIS)

    Lederman, Richard; Leichter, Isaac; Buchbinder, Shalom; Novak, Boris; Bamberger, Philippe; Fields, Scott

    2003-01-01

    The Breast Imaging Reporting and Data System (BI-RADS) was implemented to standardize characterization of mammographic findings. The purpose of the present study was to evaluate in which BI-RADS categories the changes recommended by computerized mammographic analysis are most beneficial. Archival cases including, 170 masses (101 malignant, 69 benign) and 63 clusters of microcalcifications (MCs; 36 malignant, 27 benign), were evaluated retrospectively, using the BI-RADS categories, by several radiologists, blinded to the pathology results. A computerized system then automatically extracted from the digitized mammogram features characterizing mammographic lesions, which were used to classify the lesions. The results of the computerized classification scheme were compared, by receiver operating characteristics (ROC) analysis, to the conventional interpretation. In the ''low probability of malignancy group'' (excluding BI-RADS categories 4 and 5), computerized analysis improved the A z of the ROC curve significantly, from 0.57 to 0.89. In the ''high probability of malignancy group'' (mostly category 5) the computerized analysis yielded an ROC curve with an A z of 0.99. In the ''intermediate probability of malignancy group'' computerized analysis improved the A z significantly, from 0.66 for to 0.83. Pair-wise analysis showed that in the latter group the modifications resulting from computerized analysis were correct in 83% of cases. Computerized analysis has the ability to improve the performance of the radiologists exactly in the BI-RADS categories with the greatest difficulties in arriving at a correct diagnosis. It increased the performance significantly in the problematic group of ''intermediate probability of malignancy'' and pinpointed all the cases with missed cancers in the ''low probability'' group. (orig.)

  5. Computerized adaptive testing--ready for ambulatory monitoring?

    DEFF Research Database (Denmark)

    Rose, Matthias; Bjørner, Jakob; Fischer, Felix

    2012-01-01

    Computerized adaptive tests (CATs) have abundant theoretical advantages over established static instruments, which could improve ambulatory monitoring of patient-reported outcomes (PROs). However, an empirical demonstration of their practical benefits is warranted.......Computerized adaptive tests (CATs) have abundant theoretical advantages over established static instruments, which could improve ambulatory monitoring of patient-reported outcomes (PROs). However, an empirical demonstration of their practical benefits is warranted....

  6. The portable micro-computerized multichannel spectrometer for geological application

    International Nuclear Information System (INIS)

    Fang Fang; Jia Wenyi; Zou Rongsheng; Ma Yingjie; Zhou Jianbin

    1999-01-01

    The portable micro-computerized multichannel spectrometer is based on the book computer and employs the A/D integrated circuit with 12 bits. It is a 2048 channel spectrometer which is consisted of hardware and software. The author analyzed the hardware circuit and software construction of the micro-computerized multichannel spectrometer which is suitable for filed geological application. The main technical specifications and application of the new multichannel spectrometer were also discussed

  7. The portable micro-computerized multichannel spectrometer for geological application

    International Nuclear Information System (INIS)

    Fang Fang; Jia Wenyi; Zhou Rongsheng; Ma Yingjie; Zhou Jianbin

    1999-01-01

    The portable micro-computerized multichannel spectrometer is based on the book computer and employs the A/D integrated circuit with 12 bits. It is a 2048 channel spectrometer which consists of hardware and software. The author analyzed the hardware circuit and software construction of the micro-computerized multichannel spectrometer which is suitable for field geological application. The main technical specifications and application of the new multichannel spectrometer were also discussed

  8. Computerized cost model for pressurized water reactors

    International Nuclear Information System (INIS)

    Meneely, T.K.; Tabata, Hiroaki; Labourey, P.

    1999-01-01

    A computerized cost model has been developed in order to allow utility users to improve their familiarity with pressurized water reactor overnight capital costs and the various factors which influence them. This model organizes its cost data in the standard format of the Energy Economic Data Base (EEDB), and encapsulates simplified relationships between physical plant design information and capital cost information in a computer code. Model calculations are initiated from a base case, which was established using traditional cost calculation techniques. The user enters a set of plant design parameters, selected to allow consideration of plant models throughout the typical three- and four-loop PWR power range, and for plant sites in Japan, Europe, and the United States. Calculation of the new capital cost is then performed in a very brief time. The presentation of the program's output allows comparison of various cases with each other or with separately calculated baseline data. The user can start at a high level summary, and by selecting values of interest on a display grid show progressively more and more detailed information, including links to background information such as individual cost driver accounts and physical plant variables for each case. Graphical presentation of the comparison summaries is provided, and the numerical results may be exported to a spreadsheet for further processing. (author)

  9. Language networks associated with computerized semantic indices.

    Science.gov (United States)

    Pakhomov, Serguei V S; Jones, David T; Knopman, David S

    2015-01-01

    Tests of generative semantic verbal fluency are widely used to study organization and representation of concepts in the human brain. Previous studies demonstrated that clustering and switching behavior during verbal fluency tasks is supported by multiple brain mechanisms associated with semantic memory and executive control. Previous work relied on manual assessments of semantic relatedness between words and grouping of words into semantic clusters. We investigated a computational linguistic approach to measuring the strength of semantic relatedness between words based on latent semantic analysis of word co-occurrences in a subset of a large online encyclopedia. We computed semantic clustering indices and compared them to brain network connectivity measures obtained with task-free fMRI in a sample consisting of healthy participants and those differentially affected by cognitive impairment. We found that semantic clustering indices were associated with brain network connectivity in distinct areas including fronto-temporal, fronto-parietal and fusiform gyrus regions. This study shows that computerized semantic indices complement traditional assessments of verbal fluency to provide a more complete account of the relationship between brain and verbal behavior involved organization and retrieval of lexical information from memory. Copyright © 2014 Elsevier Inc. All rights reserved.

  10. Quality criteria for abdominal computerized tomography

    International Nuclear Information System (INIS)

    Huebener, K.H.; Kurtz, B.; Metzger, H.O.F.

    1985-01-01

    Quality, not only in obdominal computerized tomography, is determined by the measurable technical parameters and, to an important extent, also bei individual factors, among which the diagnostic skill and experience of the examiner is one of the most decisive. These individual factors and the part they play with regard to the quality of CT-assisted diagnosis may well equal the technical parameters, as they significantly influence the course of examinations, resulting indications for contrast medium application, and the sensitivity of the diagnosis. The authors are convinced that especially for abdominal CT, standardized examination techniques inevitably would bring down the diagnostic quality. The technical parameters are of equal significance to achieving the diagnostic optimum, and to these parameters one has to count equipment characteristics as well as the data given by the examiner. Exposure time, spatial resolution and density differentiation are given by the equipment specifications but have to be adapted to and optimised to the clinical problems involved in every case. Another important task is that of routine imaging of given anatomic structures, for adequate evaluation of individual conditions. (orig./MG) [de

  11. Patient radiation exposure in computerized tomography

    Energy Technology Data Exchange (ETDEWEB)

    Pavlov, V [Meditsinska Akademiya, Sofia (Bulgaria)

    1980-01-01

    Radiation exposure to patients undergoing axial computerized tomography as a tool of neurological X-ray diagnostics was studied. Doses thereby delivered were compared with those from routine head films at X-ray tube parameters 200 W, 70 kV, and 70 cm target-to-patient distance. Radiation exposures were analyzed with a view to improving shielding and procedural techniques. Comparisons were made using LiF TLD measurements with an Alderson phantom (standard for axial computer tomography). Skin and intracranial space doses were compared using two computers, Siretom I and Siretom 2000, for various positionings: frontal, fronto-lateral, temporal, temporo-occipital, and occipital. In addition, patient body doses with or without shielding and doses to subjects attending sick children or restless adults were examined. Achievable protection was estimated for lead shields of 0.5 mm lead equivalent. It was concluded that radiation doses delivered to neurologic patients undergoing axial computer tomography are smaller than those resulting from conventional X-ray examinations.

  12. Single photon emission computerized tomography (SPECT)

    International Nuclear Information System (INIS)

    Ganatra, R.D.

    1992-01-01

    Tomography in nuclear medicine did not originate after the introduction of X-ray computerized tomography (CT). Even in the days of rectilinear scanner, tomography was attempted with multiple detector heads rotating around the patient, but the counts at each plane were never very high to obtain a satisfactory image. A high resolution focusing collimator can look at different depths but taking several slices in one projection was a time consuming process. Rectilinear scanners lose lot of counts in the collimator to look at one point, at on time, in one plane. It is true that attempts to do tomography with gamma camera really got a boost after the success of CT. By that time, algorithms for doing reconstruction of images also were highly refined and for advanced. Clinical application of SPECT has become widespread now, because of the development of suitable radiopharmaceuticals and improvement in instrumentation. The SPECT provides a direct measure of regional organ function and is performed with nuclides such as 123 I and 99 Tc m that emit a mono-image photon during their decay. SPECT is far less expensive than positron emission tomography

  13. Computerized 50 liter volume calibration system

    International Nuclear Information System (INIS)

    Proffitt, T.H.

    1990-01-01

    A system has been designed for the Savannah River Site that will be used to calibrate product shipping containers. For accountability purposes, it is necessary that these containers be calibrated to a very high precision. The Computerized 50 Liter Volume Calibration System (CVCS), which is based on the Ideal Gas Law (IGL), will use reference volumes with precision of no less ±0.03%, and helium to calibrate the containers to have a total error of no greater than ±0.10%. A statistical interpretation of the system has given a theoretical total calculated error of ±0.08%. Tests with the system will be performed once fabrication is complete to experimentally verify the calculated error. Since the total error was calculated using the worst case scenario, the actual error should be significantly less than the calculated value. The computer controlled, totally automated system is traceable to the National Institute of Standards and Technology. The design, calibration procedure, and statistical interpretation of the system will be discussed. 1 ref

  14. A Computerized Procedure linked to Virtual Equipment

    International Nuclear Information System (INIS)

    Jung, Yeon Sub; Song, Tae Young

    2011-01-01

    Digital, information, and communication technologies have change human's behavior. This is because human has limitation to memorize and process information. Human has to access other information and real time information for important decisions. Those technologies are playing important roles. Nuclear power plants cannot be exception. Many accidents in nuclear power plants result from absent or incorrect information. The information for nuclear personnel is context sensitive. They don't have enough time to verify the context sensitive information. Therefore they skip the information, as resulting in incident. Nuclear personnel are usually carrying static paper procedures during local task performance. The procedure guides them steps to follow. There is, however, no dynamic and context sensitive information in the paper. The effect of the work is evaluated once while getting permission of the work. Afterward they are not informed. The static paper is generally simplified, so that it does not show detail of equipment being manipulated. Particularly novice workers feel difficult to understand the procedure due to lack of detail. Pictures of equipment inserted in the procedure are not enough for comprehension. A computerized procedure linked with virtual equipment is one of the best solutions to increase the detail of procedure. Virtual equipment, however, has still limitation not to provide real time information, because the virtual equipment is not synchronized with real plants

  15. Computerized portable microwave hyperthermia quality assurance kit

    International Nuclear Information System (INIS)

    Cheung, A.Y.; Neyzari, A.

    1985-01-01

    A computerized quality assurance kit to provide precise measurement and calibration of microwave power and temperature, as well as capabilities to map SAR (Specific absorption rate) distribution in phantoms; and survey of hazardous microwave leakage has been designed. The kit is also capable of performing corelation studies on the relationship between SAR and net microwave power delivered at various anatomical sites. The kit consists of a portable microcomputer, a time-multiplexed A/D converter, a 4-channel dual directional microwave power monitor, a 4-channel thin-wire thermocouple thermometry system, an electronic thermal calibrator, a microwave leakage hazard survey meter, and a dynamic phantom tank for dosimetric analysis. Comparative performance studies were made against NBS-traceable power and temperature standards, non-perturbing optical temperature sensors, and established power and temperature measurement devices. The test results indicate that this instrument is providing its user with measurement accuracy of 0.1 0 C in temperature, 10% accuracy in power. The thin-wire thermocouple, with computer assisted error compensation, performs equally well in a strong microwave field in comparison with non-perturbing optical temperature sensors

  16. Single photon emission computerized tomography (SPECT)

    Energy Technology Data Exchange (ETDEWEB)

    Ganatra, R D

    1993-12-31

    Tomography in nuclear medicine did not originate after the introduction of X-ray computerized tomography (CT). Even in the days of rectilinear scanner, tomography was attempted with multiple detector heads rotating around the patient, but the counts at each plane were never very high to obtain a satisfactory image. A high resolution focusing collimator can look at different depths but taking several slices in one projection was a time consuming process. Rectilinear scanners lose lot of counts in the collimator to look at one point, at on time, in one plane. It is true that attempts to do tomography with gamma camera really got a boost after the success of CT. By that time, algorithms for doing reconstruction of images also were highly refined and for advanced. Clinical application of SPECT has become widespread now, because of the development of suitable radiopharmaceuticals and improvement in instrumentation. The SPECT provides a direct measure of regional organ function and is performed with nuclides such as {sup 123}I and {sup 99}Tc{sup m} that emit a mono-image photon during their decay. SPECT is far less expensive than positron emission tomography

  17. Study on forefoot by computerized tomography

    Energy Technology Data Exchange (ETDEWEB)

    Machida, Eiichi (Nihon Univ., Tokyo. School of Medicine)

    1983-10-01

    Computerized tomography (CT) was used to study coronary sections of the forefoot in both normal and abnormal human feet. CT images of the transverse arches at the metatarsal head, middle and base of the shaft were classified into five patterns. In the pattern most commonly found in normal feet, the second metatarsus appeared elevated above the other metatarsal bones at all points, and there was a gradual and even reduction in elevation from the second to the fifth metatarsal. In cases of hallux valgus, however, a variety of deformities were noted in the arc of the second to fifth metatarsals, particularly at the head. The rotation of the first metatarsus and shift of the sesamoids were measured from CT images at the head of the first metatarsus. In hallux valgus, both the rotation and the sesamoid shift appeared to have a wider angle than in the case of normal feet. In normal feet, the differences between the rotation of the first metatarsus and shift of the sesamoids were relatively small, whereas in hallux valgus there was a much greater degree of variation. Furthermore, while normal feet the variation in rotation of the first metatarsus and sesamoid shift both tended to be either great or small, in hallux valgus a large degree of sesamoid shift was sometimes found in combination with a small degree of rotation of the first metatarsus.

  18. Study on forefoot by computerized tomography

    International Nuclear Information System (INIS)

    Machida, Eiichi

    1983-01-01

    Computerized tomography (CT) was used to study coronary sections of the forefoot in both normal and abnormal human feet. CT images of the transverse arches at the metatarsal head, middle and base of the shaft were classified into five patterns. In the pattern most commonly found in normal feet, the second metatarsus appeared elevated above the other metatarsal bones at all points, and there was a gradual and even reduction in elevation from the second to the fifth metatarsal. In cases of hallux valgus, however, a variety of deformities were noted in the arc of the second to fifth metatarsals, particularly at the head. The rotation of the first metatarsus and shift of the sesamoids were measured from CT images at the head of the first metatarsus. In hallux valgus, both the rotation and the sesamoid shift appeared to have a wider angle than in the case of normal feet. In normal feet, the differences between the rotation of the first metatarsus and shift of the sesamoids were relatively small, whereas in hallux valgus there was a much greater degree of variation. Furthermore, while normal feet the variation in rotation of the first metatarsus and sesamoid shift both tended to be either great or small, in hallux valgus a large degree of sesamoid shift was sometimes found in combination with a small degree of rotatin of the first metatarsus. (author)

  19. Computerized tomographic evaluation of primary brain tumors

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Jin Ok; Lee, Jong Soon; Jeon, Doo Sung; Kim, Hong Soo; Rhee, Hak Song [Presbyterian Mediacal center, Cheonju (Korea, Republic of); Kim, Jong Deok [Inje Medical College, Paik Hospital, Pusan (Korea, Republic of)

    1985-10-15

    In a study of primary brain tumors 104 cases having satisfactory clinical, operative and histological proofs were analyzed by computerized tomography at Presbyterian Medical Center from May, 1982 to April 1985. The results were as follows: 1. The male to female ratio of primary brain tumor was 54 : 46. 2. The 2nd decade group (26%) was the most prevalent age group, followed by the 5th decade (16.3%), 1st decade (14.4%) , 3rd decade (12.5%), 4th decade (11.5%), 6th decade (10.6%), 7th decade (8.7%) in that order. 3. The incidence of primary brain tumors was found to be: glioma 64 cases (61.6%) among the GM, the most frequent 17 cases (16.3%), followed by meningioma 12 cases (11.5%), pituitary adenoma 10 cases (9.6%), craniopharyngioma 6 cases (5.8%), pinealoma and germinoma 3 cases (2.9%) respectively, and dermoid cyst 2 cases (1.9%) in that order. 4. The location of the primary brain tumors were as follows: cb. hemisphere (49%) of these 24.5% in parietal region, 11.9% in temporal region, 9.7% in frontal region, 3.0% in occipital region: juxtasella area (16.3%), cerebellar hemisphere (8.7%), parapineal and intraventricle (7.7%) respectively, cerebello-pontine angle area (5.8%), vermis and 4th ventricular region (4.8%). 5. There were no remarkable differences in the findings of pre- and post-contrast CT scanning of primary brain tumors computed with others.

  20. Neurosurgical operating computerized tomographic scanner system

    International Nuclear Information System (INIS)

    Okudera, Hiroshi; Sugita, Kenichiro; Kobayashi, Shigeaki; Kimishima, Sakae; Yoshida, Hisashi.

    1988-01-01

    A neurosurgical operating computerized tomography scanner system is presented. This system has been developed for obtaining intra- and postoperative CT images in the operating room. A TCT-300 scanner (manufactured by the Toshiba Co., Tokyo) is placed in the operating room. The realization of a true intraoperative CT image requires certain improvements in the CT scanner and operating table. To adjust the axis of the co-ordinates of the motor system of the MST-7000 microsurgical operating table (manufactured by the Mizuho Ika Co., Tokyo) to the CT scanner, we have designed an interface and a precise motor system so that the computer of the CT scanner can directly control the movement of the operating table. Furthermore, a new head-fixation system has been designed for producing artifact-free intraoperative CT images. The head-pins of the head-fixation system are made of carbon-fiber bars and titanium tips. A simulation study of the total system in the operating room with the CT scanner, operating table, and head holder using a skull model yielded a degree of error similar to that in the phantom testing of the original scanner. Three patients underwent resection of a glial tumor using this system. Intraoperative CT scans taken after dural opening showed a bulging of the cortex, a shift in the central structure, and a displacement of the cortical subarachnoid spaces under the influence of gravity. With a contrast medium the edge of the surrounding brain after resection was enhanced and the residual tumor mass was demonstrated clearly. This system makes it possible to obtain a noninvasive intraoperative image in a situation where structural shifts are taking place. (author)

  1. Integrated System Validation Usability Questionnaire: Computerized Procedures

    International Nuclear Information System (INIS)

    Garcés, Ma. I.; Torralba, B.

    2015-01-01

    The Research and Development (R&D) project on “Theoretical and Methodological Approaches to Integrated System Validation of Control Rooms, 2014-2015”, in which the research activities described in this report are framed, has two main objectives: to develop the items for an usability methodology conceived as a part of the measurement framework for performance-based control room evaluation that the OECD Halden Reactor Project will test in the experiments planned for 2015; and the statistical analysis of the data generated in the experimental activities of the Halden Man-Machine Laboratory (HAMMLAB) facility, with previous usability questionnaires, in 2010 and 2011. In this report, the procedure designed to meet the first goal of the project is described, in particular, the process followed to identify the items related to operating procedures, both computer and paper-based, one of the elements to be included in the usability questionnaire. Three phases are performed, in the first one, the approaches developed by the United States Nuclear Regulatory Commission, NRC, are reviewed, the models used by the nuclear industry and their technical support organizations, mainly, the Electric Power Research Institute, EPRI, are analyzed, and scientist advances are also explored. In the remaining stages, general and specific guidelines for computerized and paper-based procedures are compared and criteria for the preliminary selection of the items that should be incorporated into the usability questionnaire are defined. This proposal will be reviewed and adapted by the Halden Reactor Project to the design of the specific experiments performed in HAMLAB.

  2. ANCA-Negative Granulomatosis with Polyangiitis Presenting with Hypertrophic Cranial Pachymeningitis, Abducens Nerve Palsy, and Stenosis of the Internal Carotid Artery

    Directory of Open Access Journals (Sweden)

    Shohei Harabuchi

    2017-01-01

    Full Text Available We report a rare case of granulomatosis with polyangiitis (GPA presenting with hypertrophic cranial pachymeningitis (HCP, abducens nerve palsy, and stenosis of the internal carotid artery (ICA. A 59-year-old Japanese man presented with a year history of nasal obstruction and a 2-month history of slight headache. Histopathological examination of the granulomatous mucosa in the ethmoid sinuses resected by endoscopic sinus surgery revealed necrotizing vasculitis with multinucleated giant cells. The patient was diagnosed with the limited form of GPA as a result of the systemic examination. He declined immunosuppressive treatment. Eighteen months after the diagnosis of GPA, he presented with diplopia and severe headache. Though nasal findings indicating GPA were not observed in the nasal cavity, CT scan revealed a lesion of the right sphenoid sinus eroding the bone of the clivus. Gadolinium-enhanced MRI of the brain showed thickening of the dura mater around the right cavernous sinus and clivus. Magnetic resonance angiography and cerebral angiography revealed narrowing at the C5 portion of the ICA. Intravenous methylprednisolone pulse therapy followed by oral prednisolone and cyclophosphamide resolved headache and dramatically improved HCP and stenosis of the ICA.

  3. Increased IgG4-Positive Plasma Cells in Granulomatosis with Polyangiitis: A Diagnostic Pitfall of IgG4-Related Disease

    Directory of Open Access Journals (Sweden)

    Sing Yun Chang

    2012-01-01

    Full Text Available Granulomatosis with polyangiitis (Wegener’s (GPA may mimic IgG4-related disease (IgG4-RD on histologic examination of some biopsies, especially those from head and neck sites. IgG4 immunostain is often performed in this context for differential diagnosis with IgG4-RD. However, the prevalence of IgG4+ cells in GPA has not been explored. We examined the IgG4+ cells in 26 cases confirmed as GPA by a thorough clinical and pathologic assessment. Twenty-six biopsies consisted of 14 sinonasal/oral cavity/nasopharynx, 7 orbit/periorbital, 3 lung/pleura, 1 iliac fossa/kidney, and 1 dura specimens. Eight of 26 (31% biopsies revealed increased IgG4+ cells (>30/HPF and >40% in IgG4+/IgG+ ratio. The IgG4+ cells and IgG4+/IgG+ ratio ranged 37–137/hpf and 44–83%, respectively. Eight biopsies with increased IgG4+ cells were from sinonasal (n=4 or orbital/periorbital (n=4 sites. In conclusion, increased IgG4+ cells are not uncommonly seen in sinonasal or orbital/periorbital biopsies of GPA, which could pose as a diagnostic pitfall.

  4. A Diagnostic Algorithm for Eosinophilic Granulomatosis with Polyangiitis Initially Diagnosed as Lumbar Disc Hernia or Lumbar Spinal Stenosis: Personal Experience and Review of the Literature.

    Science.gov (United States)

    Nagata, Kosei; Yamamoto, Shinichi; Miyoshi, Kota; Sato, Masaki; Arino, Yusuke; Mikami, Yoji

    2016-08-01

    Eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss syndrome) is a rare systemic vasculitis and is difficult to diagnose. EGPA has a number of symptoms including peripheral dysesthesia caused by mononeuropathy multiplex, which is similar to radiculopathy due to lumbar disc hernia or lumbar spinal stenosis. Therefore, EGPA patients with mononeuropathy multiplex often visit orthopedic clinics, but orthopedic doctors and spine neurosurgeons have limited experience in diagnosing EGPA because of its rarity. We report a consecutive series of patients who were initially diagnosed as having lumbar disc hernia or lumbar spinal stenosis by at least 2 medical institutions from March 2006 to April 2013 but whose final diagnosis was EGPA. All patients had past histories of asthma or eosinophilic pneumonia, and four out of five had peripheral edema. Laboratory data showed abnormally increased eosinophil counts, and nerve conduction studies of all patients revealed axonal damage patterns. All patients recovered from paralysis to a functional level after high-dose steroid treatment. We shortened the duration of diagnosis from 49 days to one day by adopting a diagnostic algorithm after experiencing the first case.

  5. Intravenous immunoglobulin for chronic residual peripheral neuropathy in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a multicenter, double-blind trial.

    Science.gov (United States)

    Koike, Haruki; Akiyama, Kazuo; Saito, Toyokazu; Sobue, Gen

    2015-03-01

    Eosinophilic granulomatosis with polyangiitis (EGPA), previously called Churg-Strauss syndrome, frequently affects the peripheral nervous system. We conducted a multicenter, double-blind, three-arm treatment period, randomized, pre-post trial to assess the efficacy of intravenous immunoglobulin (IVIg) administration for residual peripheral neuropathy in patients with EGPA that is in remission, indicated by laboratory indices. Twenty-three patients were randomly assigned into three groups, in which the timing of IVIg and placebo administration was different. Each group received one course of intervention and two courses of placebo at 2-week intervals. Treatment effects were assessed every 2 weeks for 8 weeks. The primary outcome measure, the amount of change in the manual muscle testing sum score 2 weeks after IVIg administration, significantly increased (p = 0.002). The results over time suggested that this effect continued until the last assessment was done 8 weeks later. The number of muscles with manual muscle testing scores of three or less (p = 0.004) and the neuropathic pain scores represented by the visual analogue scale (p = 0.005) also improved significantly 2 weeks after IVIg administration. This study indicates that IVIg treatment for EGPA patients with residual peripheral neuropathy should be considered even when laboratory indices suggest remission of the disease.

  6. Anterior ischaemic optic neuropathy in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a case report and review of the literature.

    Science.gov (United States)

    Padovano, Ilaria; Pazzola, Giulia; Pipitone, Nicolò; Cimino, Luca; Salvarani, Carlo

    2014-01-01

    We report a 62-year-old man with mild fever, headache and acute visual loss in his right eye due to anterior ischaemic optic neuropathy (AION), followed a few days later by pain in the legs and left arm associated with numbness and weakness. Giant cell arteritis complicated by AION was suspected at the beginning and high-dose oral glucocorticoids were started. However, on the basis of the past medical history of nasal polyposis, asthma, and hypereosynophilia as well as of further investigations (biopsy of the nasal mucosa showing granulomatous inflammation with a rich eosinophilic infiltrate, electromyography demonstrating, mononeuritis multiplex and positive p-ANCA), eosinophilic granulomatosis with polyangiitis (EGPA), previously known as Churg-Strauss syndrome, was diagnosed. Because visual acuity in the right eye deteriorated despite glucocorticoid therapy, pulse intravenous cyclophosphamide was started, subsequently replaced by oral azathioprine, while prednisone was slowly tapered. This treatment led to gradual improvement of the neurological symptoms, whereas the right visual impairment remained unchanged. EGPA-related AION is an uncommon lesion that is probably due to vasculitic involvement of posterior ciliary and/or chorioretinal arteries. The prognosis of established AION is poor for the affected eye, even when glucocorticoid treatment is started immediately. However, early recognition of AION and prompt aggressive treatment with high-dose glucocorticoids plus cyclophosphamide can prevent visual loss in the unaffected eye.

  7. [Cavitating lung lesions in the course of ANCA-associated vasculitis: differential diagnostic aspects].

    Science.gov (United States)

    Kirchner, J; Raab, H P; Länger, F; Wigand, R; Mitrou, P; Jacobi, V

    1998-05-01

    Antineutrophil cytoplasmatic antibodies (ANCA)-associated vasculitides (Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome) show quite variable courses. Clinical features of the full blown generalized systemic vasculitis are usually found in the respiratory tract and the kidney. Pulmonary involvement of Wegener's granulomatosis shows commonly nodules and cavitations but also diffuse alveolar hemorrhage. We report the case of a 57 year-old man suffering from dyspnea, thoracal pain, arthralgia, purpura, scleritis and tinitus. Specimen of the kidney showed segmental glomerulosclerosis and tubulointerstitial nephritis. Because of the presence of cANCA Wegener's disease was assumed. Pulmonary infiltrates developed under immunosuppressive treatment with cyclophosphamid. As differential diagnosis of the pulmonary infiltrates, we considered invasive pulmonary aspergillosis as well as infiltrates due to Wegener's granulomatosis. In spite of maximal therapeutic management of patient died of respiratory and cardiovascular failure. The findings at autopsy showed distinct invasive pulmonary aspergillosis and perifocal hemorrhage.

  8. Computerized photogrammetry used to calculate the brow position index.

    Science.gov (United States)

    Naif-de-Andrade, Naif Thadeu; Hochman, Bernardo; Naif-de-Andrade, Camila Zirlis; Ferreira, Lydia Masako

    2012-10-01

    The orbital region is of vital importance to facial expression. Brow ptosis, besides having an impact on facial harmony, is a sign of aging. Various surgical techniques have been developed to increase the efficacy of brow-lift surgery. However, no consensus method exists for an objective measurement of the eyebrow position due to the curvature of the face. Therefore, this study aimed to establish a method for measuring the eyebrow position using computerized photogrammetry. For this study, 20 orbital regions of 10 volunteers were measured by direct anthropometry using a digital caliper and by indirect anthropometry (computerized photogrammetry) using standardized digital photographs. Lines, points, and distances were defined based on the position of the anthropometric landmarks endocanthion and exocanthion and then used to calculate the brow position index (BPI). Statistical analysis was performed using Student's t test with a significance level of 5 %. The BPI values obtained by computerized photogrammetric measurements did not differ significantly from those obtained by direct anthropometric measurements (p > 0.05). The mean BPI was 84.89 ± 10.30 for the computerized photogrammetric measurements and 85.27 ± 10.67 for the direct anthropometric measurements. The BPI defined in this study and obtained by computerized photogrammetry is a reproducible and efficient method for measuring the eyebrow position. This journal requires that authors assign a level of evidence to each article.

  9. Computerized videodefecography versus defecography: do we need radiographs?

    Directory of Open Access Journals (Sweden)

    Carlos Walter Sobrado

    Full Text Available CONTEXT AND OBJECTIVE: Defecography has been recognized as a valuable method for evaluating patients with evacuation disorders. It consists of the use of static radiography and fluoroscopy to record different situations within anorectal dynamics. Conventionally, rectal parameters are measured using radiograms. It is rare for fluoroscopy alone to be used. Computer software has been developed with the specific aim of calculating these measurements from digitized videotaped images obtained during fluoroscopy, without the need for radiographic film, thereby developing a computerized videodefecography method. The objective was thus to compare measurements obtained via computerized videodefecography with conventional measurements and to discuss the advantages of the new method. DESIGN AND SETTING: Prospective study at the radiology service of Hospital das Clínicas, Universidade de São Paulo. METHOD: Ten consecutive normal subjects underwent videodefecography. The anorectal angle, anorectal junction, puborectalis muscle length, anal canal length and degree of anal relaxation were obtained via the conventional method (using radiography film and via computerized videodefecography using the ANGDIST software. Measurement and analysis of these parameters was performed by two independent physicians. RESULTS: Statistical analysis confirmed that the measurements obtained through direct radiography film assessment and using digital image analysis (computerized videodefecography were equivalent. CONCLUSIONS: Computerized videodefecography is equivalent to the traditional defecography examination. It has the advantage of offering reduced radiation exposure through saving on the use of radiography.

  10. Experience feedback of computerized controlled nuclear power plants

    International Nuclear Information System (INIS)

    Poizat, F.

    2004-01-01

    The N4 step of French PWR-type nuclear power plants is characterized by an instrumentation and control system entirely computerized (operation procedures including normal and accidental operation). Four power plants of this type (Chooz and Civaux sites) of 1450 MWe each were connected to the power grid between August 1996 and December 1999. The achievement of this program make it possible and necessary to carry out an experience feedback about the development, successes and difficulties encountered in order to draw out some lessons for future realizations. This is the aim of this article: 1 - usefulness and difficulties of such an experience feedback: evolution of instrumentation and control systems, necessary cautions; 2 - a successful computerized control: checking of systems operation, advantages, expectations; 3 - efficiency of computerized systems: demonstration of operation safety, profitability; 4 - conclusions and interrogations: system approach instead of 'micro-software' approach, commercial or 'made to measure' products, contract agreement with a supplier, when and how upgrading. (J.S.)

  11. Quality criteria in computerized tomography of the chest

    International Nuclear Information System (INIS)

    Doehring, W.

    1985-01-01

    The quality of thoracical computerized tomography (CT) - like any other CT examination - depends from the quality of the equipment used, from the skill of the examinor and the properties of the patient. Concerning computerized chest tomograms, rapid scan equipment should be used only and slow translation - rotation systems should not be used any more. Whereas the quality of computerized tomograms may be influenced by the patient in the scanning process only, the examining physician will decisively influence the possible informative value of the examination also in the reconstruction of the CT value matrix, in single demonstration of CT values and, possibly, in additional measurement value processing as well as in the interpretation of findings. Use of equipment should always consider the technical potential provided by the equipment to be oriented to the clinical issue, and the conditions preset by the patient. (orig.) [de

  12. Cognitive task analysis and the design of computerized operator aids

    International Nuclear Information System (INIS)

    Andersson, H.

    1985-01-01

    The new technological possibilities have led to the initiation of many projects for the design and evaluation of computerized operator support systems to be implemented in nuclear power plant control rooms. A typical finding so far has been that operators often have a positive attitude towards such systems but still don't use them very much, mostly because they find almost the same information on the conventional control boards which they are accustomed to use. Still, however, there is a widely shared belief that conventional control rooms have short-comings that make the use of computerized aids necessary. One reason for the limited success so far is that the new systems often are poorly integrated with the existing conventional instrumentation and with the working procedures. The reluctance to use new computer based aids, despite their nice features, is therefore probably caused by an inadequate task analysis made prior to the design of these computerized operator support systems

  13. Computerized access to materials data. A progress report

    International Nuclear Information System (INIS)

    Rumble, J. Jr.

    1985-01-01

    As the effort to build a comprehensive computerized materials data system grows, it becomes more obvious that the benefits will be far-reaching. During this workshop, the enthusiasm of the participants grew steadily until the questions became not''What,'' but ''When?''. The engineering community within the United States has banded together many times to advance progress in engineering capability. The computerized materials data system requires such an effort, and the rewards will be substantial. Chapter 3 identifies changes in the use of materials data in the Nuclear Power Industry. Chapter 4 describes the EPRI experience in building computerized materials databases. In Chapter 5, the National Materials Property Data Network is discussed. The next four chapters present summaries of the workshop discussions and its conclusions. Chapter 6 discusses the content of the proposed system, Chapter 7 its size and the data sources, and Chapter 8 the user interfaces and system capabilities. In Chapter 9, ways of making further progress are outlined

  14. Current Human Reliability Analysis Methods Applied to Computerized Procedures

    Energy Technology Data Exchange (ETDEWEB)

    Ronald L. Boring

    2012-06-01

    Computerized procedures (CPs) are an emerging technology within nuclear power plant control rooms. While CPs have been implemented internationally in advanced control rooms, to date no US nuclear power plant has implemented CPs in its main control room (Fink et al., 2009). Yet, CPs are a reality of new plant builds and are an area of considerable interest to existing plants, which see advantages in terms of enhanced ease of use and easier records management by omitting the need for updating hardcopy procedures. The overall intent of this paper is to provide a characterization of human reliability analysis (HRA) issues for computerized procedures. It is beyond the scope of this document to propose a new HRA approach or to recommend specific methods or refinements to those methods. Rather, this paper serves as a review of current HRA as it may be used for the analysis and review of computerized procedures.

  15. Pain Perception: Computerized versus Traditional Local Anesthesia in Pediatric Patients.

    Science.gov (United States)

    Mittal, M; Kumar, A; Srivastava, D; Sharma, P; Sharma, S

    2015-01-01

    Local anesthetic injection is one of the most anxiety- provoking procedure for both children and adult patients in dentistry. A computerized system for slow delivery of local anesthetic has been developed as a possible solution to reduce the pain related to the local anesthetic injection. The present study was conducted to evaluate and compare pain perception rates in pediatric patients with computerized system and traditional methods, both objectively and subjectively. It was a randomized controlled study in one hundred children aged 8-12 years in healthy physical and mental state, assessed as being cooperative, requiring extraction of maxillary primary molars. Children were divided into two groups by random sampling - Group A received buccal and palatal infiltration injection using Wand, while Group B received buccal and palatal infiltration using traditional syringe. Visual Analog scale (VAS) was used for subjective evaluation of pain perception by patient. Sound, Eye, Motor (SEM) scale was used as an objective method where sound, eye and motor reactions of patient were observed and heart rate measurement using pulse oximeter was used as the physiological parameter for objective evaluation. Patients experienced significantly less pain of injection with the computerized method during palatal infiltration, while less pain was not statistically significant during buccal infiltration. Heart rate increased during both buccal and palatal infiltration in traditional and computerized local anesthesia, but difference between traditional and computerized method was not statistically significant. It was concluded that pain perception was significantly more during traditional palatal infiltration injection as compared to computerized palatal infiltration, while there was no difference in pain perception during buccal infiltration in both the groups.

  16. Impact of Multidetector Computerized Tomography (MDCT) On The General Population

    Energy Technology Data Exchange (ETDEWEB)

    Leite, B.B.; Ribeiro, N.C. [Servico de Radiologia, Hospital de Curry Cabral, Rua da Beneficencia, 8, 1069-166 Lisboa (Portugal)

    2009-05-15

    Multidetector computerized tomography (MDCT) appeared in the early 1990s, as a technological evolution of computerized tomography. As one would expect, the evolution continues and, each year, more powerful equipments appear, with new medical applications. However, the general use of this technique has lead to the dramatic increase on the general population irradiation. Special concern is required regarding the most vulnerable groups, like the pediatric population, the pregnant and the young female. Due to a larger awareness of this irradiation risks, some initiatives have been developed, coming from different areas, aiming to maximize the benefit to risk ratio of MDCT. (author)

  17. Recurrent lymph node metastases after craniocervical tumours: Computerized tomography

    International Nuclear Information System (INIS)

    Helmberger, H.; Lenz, M.; Kersting-Sommerhoff, B.; Bautz, W.; Kretz, S.

    1992-01-01

    A total of 544 CT examinations of the craniocervical region carried out in 231 patients were analyzed on a retrospective basis in order to assess the clinical value of contrast-enhanced computerized tomography, being carried out either for comparison with or in combination with clinical control examinations, in the post-therapeutic surveillance of patients treated for craniocervical tumours. The diagnostic accuracy attained with computerized tomography in the detection of recurrent lymph node metastases was 95% and thus superior to that determined for clinical control examinations (80%). (orig./GDG) [de

  18. Improved survival with renal transplantation for end-stage renal disease due to granulomatosis with polyangiitis: data from the United States Renal Data System.

    Science.gov (United States)

    Wallace, Zachary S; Wallwork, Rachel; Zhang, Yuqing; Lu, Na; Cortazar, Frank; Niles, John L; Heher, Eliot; Stone, John H; Choi, Hyon K

    2018-05-14

    Renal transplantation is the optimal treatment for selected patients with end-stage renal disease (ESRD). However, the survival benefit of renal transplantation among patients with ESRD attributed to granulomatosis with polyangiitis (GPA) is unknown. We identified patients from the United States Renal Data System with ESRD due to GPA (ESRD-GPA) between 1995 and 2014. We restricted our analysis to waitlisted subjects to evaluate the impact of transplantation on mortality. We followed patients until death or the end of follow-up. We compared the relative risk (RR) of all-cause and cause-specific mortality in patients who received a transplant versus non-transplanted patients using a pooled logistic regression model with transplantation as a time-varying exposure. During the study period, 1525 patients were waitlisted and 946 received a renal transplant. Receiving a renal transplant was associated with a 70% reduction in the risk of all-cause mortality in multivariable-adjusted analyses (RR=0.30, 95% CI 0.25 to 0.37), largely attributed to a 90% reduction in the risk of death due to cardiovascular disease (CVD) (RR=0.10, 95% 0.06-0.16). Renal transplantation is associated with a significant decrease in all-cause mortality among patients with ESRD attributed to GPA, largely due to a decrease in the risk of death to CVD. Prompt referral for transplantation is critical to optimise outcomes for this patient population. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  19. Anti-IgE Monoclonal Antibody (Omalizumab) in Refractory and Relapsing Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss): Data on Seventeen Patients.

    Science.gov (United States)

    Jachiet, Marie; Samson, Maxime; Cottin, Vincent; Kahn, Jean-Emmanuel; Le Guenno, Guillaume; Bonniaud, Philippe; Devilliers, Hervé; Bouillet, Laurence; Gondouin, Anne; Makhlouf, Fatma; Meaux-Ruault, Nadine; Gil, Helder; Bienvenu, Boris; Coste, André; Groh, Matthieu; Giraud, Violaine; Dominique, Stéphane; Godeau, Bertrand; Puéchal, Xavier; Khouatra, Chahera; Ruivard, Marc; Le Jeunne, Claire; Mouthon, Luc; Guillevin, Loïc; Terrier, Benjamin

    2016-09-01

    To describe the efficacy and safety of omalizumab, an anti-IgE monoclonal antibody, in patients with refractory and/or relapsing eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA). We conducted a nationwide retrospective study including EGPA patients who received omalizumab. Response was defined as the absence of asthma and/or sinonasal exacerbations with a prednisone dosage of ≤7.5 mg/day (complete response) or >7.5 mg/day (partial response). Seventeen patients (median age 45 years) received omalizumab for severe steroid-dependent asthma (88%) and/or sinonasal involvement (18%). After a median follow-up of 22 months, 6 patients (35%) achieved a complete response, 5 patients (30%) achieved a partial response, and 6 patients (35%) had no improvement. The median Birmingham Vasculitis Activity Score decreased from 2.5 at baseline to 0.5 at 12 months. The median number of exacerbations per month decreased from 1 at baseline to 0 at 12 months, and the median forced expiratory volume in 1 second increased from 63% of the percent predicted at baseline to 85% of the percent predicted at 12 months. The median prednisone dosage decreased from 16 mg/day at baseline to 11 mg/day at 6 months and 9 mg/day at 12 months. Omalizumab was discontinued in 8 patients (47%) during follow-up, because of remission (12.5%), adverse event despite disease remission (12.5%), refractory disease (25%), or relapse (50%). Relapses included retrobulbar optic neuritis attributable to EGPA in 2 patients and severe asthma flare in 2 others. The results of this study suggest that omalizumab may have a corticosteroid-sparing effect in EGPA patients with asthmatic and/or sinonasal manifestations, but reducing the corticosteroid dose may also increase the risk of severe EGPA flares, which raises the question of the safety of omalizumab in patients with EGPA. © 2016, American College of Rheumatology.

  20. Unfavorably Altered Fibrin Clot Properties in Patients with Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Association with Thrombin Generation and Eosinophilia.

    Science.gov (United States)

    Mastalerz, Lucyna; Celińska-Lӧwenhoff, Magdalena; Krawiec, Piotr; Batko, Bogdan; Tłustochowicz, Witold; Undas, Anetta

    2015-01-01

    Given reports on the increased prevalence of thromboembolic incidents in patients with eosinophilic granulomatosis with polyangiitis (EGPA; Churg-Strauss syndrome), we investigated whether fibrin clot properties are unfavorably altered in EGPA. Ex vivo plasma fibrin clot characteristics, including clot permeability, turbidimetry and efficiency of fibrinolysis using two assays, were investigated in 34 consecutive patients with remission in EGPA according to the Birmingham Vasculitis Activity Score version 3 (23 female, 11 male), aged 48 (range, 21-80) years. The control group comprised 34 age- and sex- matched volunteers. Compared with controls, patients with EGPA were characterized by denser fiber clots (estimated pore size, Ks, 7.30±0.93 vs 10.14±1.07 10-9 cm2), faster fibrin polymerization (lag phase in a turbidimetric curve, 41.8±3.6 vs 47.4±2.9 s), thicker fibrin fibers (maximum absorbance, ΔAbs, 0.87±0.09 vs 0.72±0.07), higher maximum levels of D-dimer released from clots (DDmax 4.10±0.46 vs 3.54±0.35 mg/L), and prolonged clot lysis time (t50%; 9.50±1.45 vs 7.56±0.87 min); all p<0.0001. Scanning electron microscopy images confirmed denser plasma fibrin networks composed of thinner fibers formed in EGPA. Antineutrophil cytoplasmic antibody status and C-reactive protein did not affect clot variables. Multivariate analysis adjusted for fibrinogen showed that Ks was predicted by eosinophil count, peak thrombin generation, factor VIII, and soluble CD40 ligand, whereas eosinophil count, peak thrombin generation and antiplasmin predicted t50%. This study is the first to show that EGPA is associated with prothrombotic plasma fibrin clot phenotype, which may contribute to thromboembolic manifestations reported in this disease.

  1. Unfavorably Altered Fibrin Clot Properties in Patients with Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome: Association with Thrombin Generation and Eosinophilia.

    Directory of Open Access Journals (Sweden)

    Lucyna Mastalerz

    Full Text Available Given reports on the increased prevalence of thromboembolic incidents in patients with eosinophilic granulomatosis with polyangiitis (EGPA; Churg-Strauss syndrome, we investigated whether fibrin clot properties are unfavorably altered in EGPA.Ex vivo plasma fibrin clot characteristics, including clot permeability, turbidimetry and efficiency of fibrinolysis using two assays, were investigated in 34 consecutive patients with remission in EGPA according to the Birmingham Vasculitis Activity Score version 3 (23 female, 11 male, aged 48 (range, 21-80 years. The control group comprised 34 age- and sex- matched volunteers.Compared with controls, patients with EGPA were characterized by denser fiber clots (estimated pore size, Ks, 7.30±0.93 vs 10.14±1.07 10-9 cm2, faster fibrin polymerization (lag phase in a turbidimetric curve, 41.8±3.6 vs 47.4±2.9 s, thicker fibrin fibers (maximum absorbance, ΔAbs, 0.87±0.09 vs 0.72±0.07, higher maximum levels of D-dimer released from clots (DDmax 4.10±0.46 vs 3.54±0.35 mg/L, and prolonged clot lysis time (t50%; 9.50±1.45 vs 7.56±0.87 min; all p<0.0001. Scanning electron microscopy images confirmed denser plasma fibrin networks composed of thinner fibers formed in EGPA. Antineutrophil cytoplasmic antibody status and C-reactive protein did not affect clot variables. Multivariate analysis adjusted for fibrinogen showed that Ks was predicted by eosinophil count, peak thrombin generation, factor VIII, and soluble CD40 ligand, whereas eosinophil count, peak thrombin generation and antiplasmin predicted t50%.This study is the first to show that EGPA is associated with prothrombotic plasma fibrin clot phenotype, which may contribute to thromboembolic manifestations reported in this disease.

  2. Different responses to treatment across classified diseases and severities in Japanese patients with microscopic polyangiitis and granulomatosis with polyangiitis: a nationwide prospective inception cohort study.

    Science.gov (United States)

    Sada, Ken-ei; Yamamura, Masahiro; Harigai, Masayoshi; Fujii, Takao; Takasaki, Yoshinari; Amano, Koichi; Fujimoto, Shouichi; Muso, Eri; Murakawa, Yohko; Arimura, Yoshihiro; Makino, Hirofumi

    2015-11-02

    This study aims to elucidate the prognosis and the effectiveness of current treatments for Japanese patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). Patients with newly diagnosed MPA and GPA were enrolled in a nationwide, prospective, inception cohort study from 22 tertiary Japanese institutions, and treatment patterns and responses were evaluated for 24 months. Primary outcome measures were rates of remission (Birmingham Vasculitis Activity Score, 0) and remission with low-dose glucocorticoids (GC) (prednisolone ≤ 10 mg) (GC remission). Of 156 enrolled patients, 78 MPA patients and 33 GPA patients were included. Concomitant cyclophosphamide (CY) was used in 24 MPA (31 %) and 20 GPA (60 %) patients during the initial 3 weeks of treatment. After 6 months, remission was achieved in 66 MPA (85 %) and 29 GPA (87 %) patients, while GC remission was obtained in only 31 MPA (40 %) and 13 GPA (39 %) patients. During the 24-month period, 14 MPA patients and 2 GPA patients died; end stage renal disease (ESRD) was noted in 13 MPA patients but no GPA patients. Patients with severe disease, according to the European Vasculitis Study Group (EUVAS) classification, showed poorer ESRD-free and overall survival rates than those with generalized disease (p < 0.0001). There were no differences in relapse-free survival rates between GPA and MPA, among EUVAS-defined disease severity categories, and between anti-neutrophil cytoplasmic antibody subspecialties. The majority of Japanese patients with MPA and GPA received treatment with high-dose GC and limited CY use, and showed high remission and relapse-free survival rates but low GC remission rates in clinical practice. University Hospital Medical Information Network Clinical Trials Registry UMIN000001648 . Registered 28 February 2009.

  3. Coupling two iteratives algorithms for density measurements by computerized tomography

    International Nuclear Information System (INIS)

    Silva, L.E.M.C.; Santos, C.A.C.; Borges, J.C.; Frenkel, A.D.B.; Rocha, G.M.

    1986-01-01

    This work develops a study for coupling two iteratives algotithms for density measurements by computerized tomography. Tomographies have been obtained with an automatized prototype, controled by a microcomputer, projected and assembled in the Nuclear Instrumentation Laboratory, at COPPE/UFRJ. Results show a good performance of the tomographic system, and demonstrate the validity of the method of calculus adopted. (Author) [pt

  4. Multidimensional Computerized Adaptive Testing for Indonesia Junior High School Biology

    Science.gov (United States)

    Kuo, Bor-Chen; Daud, Muslem; Yang, Chih-Wei

    2015-01-01

    This paper describes a curriculum-based multidimensional computerized adaptive test that was developed for Indonesia junior high school Biology. In adherence to the Indonesian curriculum of different Biology dimensions, 300 items was constructed, and then tested to 2238 students. A multidimensional random coefficients multinomial logit model was…

  5. Evaluation of the absorbed dose in odontological computerized tomography

    International Nuclear Information System (INIS)

    Legnani, Adriano; Schelin, Hugo R.; Rocha, Anna Silvia P.S. da; Khoury, Helen J.

    2011-01-01

    This paper evaluated the absorbed dose at the surface entry known as 'cone beam computed tomography' (CBCT) in odontological computerized tomography. Examination were simulated with CBCT for measurements of dose. A phantom were filled with water, becoming scatter object of radiation. Thermoluminescent dosemeters were positioned on points correspondent to eyes and salivary glands

  6. Wilderness Management... A Computerized System for Summarizing Permit Information

    Science.gov (United States)

    Gary H. Elsner

    1972-01-01

    Permits were first needed for visits to wilderness areas in California during summer 1971. A computerized system for analyzing these permits and summarizing information from them has been developed. It produces four types of summary tables: point-of-origin of visitors; daily variation in total number of persons present; variations in group size; and variations in...

  7. Computerized operation of the DIII-D neutral beams

    International Nuclear Information System (INIS)

    Glad, A.S.; Tooker, J.F.

    1986-01-01

    Operation of the DIII-D neutral beams utilizes computerized control to provide routine tokamak beam heating shots and an effective method for automatic ion source operation. Computerized control reduces operational complexity, thus providing consistent reliability and availability of beams and a significant reduction in the the costs of routine operation. The objectives in implementing computerized control for operation were: (1) to improve operator efficiency for controlling multiple beam lines and increasing beam availability through standard procedures, (2) to provide a simplified scheme that operators and coordinators can construct and maintain, and (3) to provide a single integrated mechanism for both tokamak operation and automatic source conditioning. The years of experience in operating neutral beams at Doublet III provided the data necessary to meet the objectives. The method for computerized control consisted of three integrated functions: (1) a structured command language was implemented to provide the mechanism for automatically sequencing beams, (2) a historical file was constructed from the operational parameters to characterize the ion source, and consists of data from approximately 100,000 beam shots, and (3) procedures were developed integrating the language to the historical file for normal operation and source conditioning. This paper describes the method for sequencing beams automatically, the structure of the historical data file, and the procedures which integrate the historical data with tokamak operation and automatic source conditioning

  8. The computerized patient record: Where do we stand?

    NARCIS (Netherlands)

    Jaspers, M. W. M.; Knaup, P.; Schmidt, D.

    2006-01-01

    OBJECTIVES: To provide an overview of trends in research, developments and implementations of the computerized patient record (CPR) of the last two years. METHODS: We surveyed the medical informatics literature, spanning the years 2004-2005, focusing on publications on CPRs. RESULTS: The main trends

  9. Computerized tomography in the examination of the orbit

    International Nuclear Information System (INIS)

    Ammerich, H.; Wackenheim, A.; Golabek, R.

    1980-01-01

    The importance of computerized tomography in the ophtalmological diagnosis is discussed. A great value of the information obtained by this not cumbersome method is stressed. The findings achieved this method in the most frequent diseases of the eyeball, orbit and neighbouring anatomical structures are described. (author)

  10. Contribution of computerized tomography to orbit fracture diagnosis

    International Nuclear Information System (INIS)

    Nemeth, T.; Sobota, J.

    1984-01-01

    Suitability and specificity of examinations using computerized tomography are discussed for diagnoses fractures of the orbit including accurate anatomical localization of traumatic changes. The possibility of accurate assessment of the drop of the floor of the orbit which is essential for determination of the thickness of the bone or cartilaginous graft under the eyeball is also important

  11. Development and validation of the computerized family relations

    NARCIS (Netherlands)

    Skoczen, I.; Cieciuch, J.; Oud, J.H.L.; Welzen, K.F.

    2015-01-01

    The aim of the present study was to develop and investigate the psychometric properties of the Computerized Family Relations Test (CFRT) for children. This test assesses the quality of family relationships with the mother and father from a child's perspective. The CFRT consists of six scales

  12. Serial assessment of doxorubicin cardiomyopathy with the computerized scintillation probe

    International Nuclear Information System (INIS)

    Strashun, A.; Goldsmith, S.J.; Horowitz, S.F.

    1982-01-01

    Cardiac function was serially monitored in 55 patients receiving adriamycin chemotherapy over 18 months with quantitative radionuclide assessment by both a nonimaging computerized scintillation probe and gamma camera-computer imaging. Interval ejection fraction change was comparable with both techniques and predicted incipient cardiotoxicity. Probe data revealed ejection fraction decline was antedated by decline left ventricular emptying and filling rates

  13. Emission computerized-tomography and determination of local brain function

    International Nuclear Information System (INIS)

    Kuhl, D.E.; Alavi, A.; Reivich, M.; Edwards, R.Q.; Fenton, C.A.; Zimmerman, R.A.

    1975-01-01

    Methods for the three dimensional reconstruction of /sup 99m/Tc brain scans are described. The diagnostic advantages of computerized tomography in the localization of brain tumors and in measurements of local cerebral blood flow are discussed. (U.S.)

  14. Cranial Computerized Tomography In The Evaluation Of Stroke ...

    African Journals Online (AJOL)

    206 patients clinically diagnosed as stroke / cerebrovascular accidents (CVA) were investigated using computerized tomography (CT) scan. 19 patients (9%) had normal scan. While 20(9.7%) had other lesions including atrophy and tumours. Of the 167 (18. %) patients proven to have suffered a cerebro- vascular accident ...

  15. Procedures for Selecting Items for Computerized Adaptive Tests.

    Science.gov (United States)

    Kingsbury, G. Gage; Zara, Anthony R.

    1989-01-01

    Several classical approaches and alternative approaches to item selection for computerized adaptive testing (CAT) are reviewed and compared. The study also describes procedures for constrained CAT that may be added to classical item selection approaches to allow them to be used for applied testing. (TJH)

  16. A Computerized Approach to Trickle-Process, Random Assignment.

    Science.gov (United States)

    Braucht, G. Nicholas; Reichardt, Charles S.

    1993-01-01

    Procedures for implementing random assignment with trickle processing and ways they can be corrupted are described. A computerized method for implementing random assignment with trickle processing is presented as a desirable alternative in many situations and a way of protecting against threats to assignment validity. (SLD)

  17. The Pattern of Significant Lesions Found in Computerized ...

    African Journals Online (AJOL)

    Introduction: Seizures are common reasons for neurologic consultations and investigations. In the absence of magnetic resonance imaging, computerized tomography scanning of the brain is a reliable and cheaper alternative. Little is known about the pattern of brain lesions in patients with recurrent seizures in Nigeria.

  18. Computerized tomographic findings in children with head trauma in ...

    African Journals Online (AJOL)

    Objective: To describe the computerized tomographic findings in children with head trauma who presented at the University of Benin Teaching Hospital, Benin City, Nigeria. Methods: It is a retrospective review of patients aged 0 – 15 years with suspected intracranial injury (ICI) following head trauma, who presented for CT ...

  19. Significance of computerized tomography and nasal cytology in the ...

    African Journals Online (AJOL)

    Ehab

    assessment of sinus disease in asthmatic children. Rhinosinusitis is a common asthma comorbidity. Nasal eosinophil or neutrophil score >0.5 provides a better predictive value for rhinosinusitis compared to total serum IgE. Keywords: computerized tomography, nasal sinus, asthma, sinusitis, allergic rhinitis, children.

  20. The Pattern of Significant Lesions Found in Computerized ...

    African Journals Online (AJOL)

    2017-12-05

    Dec 5, 2017 ... Introduction: Seizures are common reasons for neurologic consultations and investigations. In the absence of magnetic resonance imaging, computerized tomography scanning of the brain is a reliable and cheaper alternative. Little is known about the pattern of brain lesions in patients with recurrent ...

  1. Towards Computerized Adaptive Assessment Based on Structured Tasks

    NARCIS (Netherlands)

    Tvarožek, Jozef; Kravcik, Milos; Bieliková, Mária

    2008-01-01

    Tvarožek, J., Kravčík, M., & Bieliková, M. (2008). Towards Computerized Adaptive Assessment Based on Structured Tasks. In W. Nejdl et al. (Eds.), Adaptive Hypermedia and Adaptive Web-Based Systems (pp. 224-234). Springer Berlin / Heidelberg.

  2. Robinson's computerized model of eye muscle mechanics revised.

    NARCIS (Netherlands)

    H.J. Simonsz (Huib)

    1994-01-01

    textabstractThe computerized model of static eye-muscle mechanics developed by Robinson was revised extensively and improved. An extensive literature study yielded additional information on the average diameter of the eye as related to age, on the average location of the insertions and origins of

  3. Radiation exposure of the gonads in infant brain computerized tomography

    International Nuclear Information System (INIS)

    Berndt, L.; Rosenkranz, G.; Tellkamp, H.

    1988-01-01

    In 61 babies and infants the gonadal dose due to brain computerized tomography was determined over the symphysis by thermoluminescent dosimetry. The average radiation dose was 43 mGy corresponding with data reported. Shielding of the testes in infants is an additional burden and worth discussing because of the low absolute gonadal dose

  4. Quality control of online calibration in computerized assessment

    NARCIS (Netherlands)

    Glas, Cornelis A.W.

    In computerized adaptive testing, updating item parameter estimates using adaptive testing data is often called online calibration. This study investigated how to evaluate whether the adaptive testing data used for online calibration sufficiently fit the item response model used. Three approaches

  5. Computerized x-ray radiographic system for fuel pellet measurements

    International Nuclear Information System (INIS)

    Green, D.R.; Karnesky, R.A.; Bromley, C.

    1977-01-01

    The development and operation of a computerized system for determination of fuel pellet diameters from x-ray radiography is described. Actual fuel pellet diameter measurements made with the system are compared to micrometer measurements on the same pellets, and statistically evaluated. The advantages and limitations of the system are discussed, and recommendations are made for further development

  6. A Computerized Clinical Support System and Psychological Laboratory.

    Science.gov (United States)

    Cassel, Russell N.

    1978-01-01

    Advocating "holistic" medicine, this article details the benefits to be derived from using a computerized clinical support system in a psychological laboratory focusing on internal healing where the client/patient becomes a committed partner utilizing biofeedback equipment, gaming, and simulation to achieve self-understanding and…

  7. Use of computerized tomography and magnetic resonance imaging

    International Nuclear Information System (INIS)

    Tjoerstad, K.

    1992-01-01

    This is a neurologist's opinion on how computerized tomography and magnetic resonance imaging have improved the doctor's diagnostic possibilities, changed patient/doctor relationship and increased the patients' expectations from diagnostic tests. How should the often conflicting interests of patients, society and doctors be handled? 15 refs., 1 fig., 1 tab

  8. Radio astronomical interferometry and x-ray's computerized tomography

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, L F [Universidad Nacional Autonoma de Mexico, Mexico City. Inst. de Astronomia

    1982-01-01

    Radio astronomical interferometry and computerized tomography are techniques of great importance for astronomy and medicine, respectively. In this paper we emphasize that both techniques are based on the same mathematical principles, and present them as an example of interaction between basic and applied science.

  9. Quality control of on-line calibration in computerized assessment

    NARCIS (Netherlands)

    Glas, Cornelis A.W.

    1998-01-01

    In computerized adaptive testing, updating parameter estimates using adaptive testing data is often called online calibration. In this paper, how to evaluate whether the adaptive testing model used for online calibration fits the item response model used sufficiently is studied. Three approaches are

  10. Multiple Maximum Exposure Rates in Computerized Adaptive Testing

    Science.gov (United States)

    Ramon Barrada, Juan; Veldkamp, Bernard P.; Olea, Julio

    2009-01-01

    Computerized adaptive testing is subject to security problems, as the item bank content remains operative over long periods and administration time is flexible for examinees. Spreading the content of a part of the item bank could lead to an overestimation of the examinees' trait level. The most common way of reducing this risk is to impose a…

  11. Monkeys Exhibit Prospective Memory in a Computerized Task

    Science.gov (United States)

    Evans, Theodore A.; Beran, Michael J.

    2012-01-01

    Prospective memory (PM) involves forming intentions, retaining those intentions, and later executing those intended responses at the appropriate time. Few studies have investigated this capacity in animals. Monkeys performed a computerized task that assessed their ability to remember to make a particular response if they observed a PM cue embedded…

  12. Sequential Computerized Mastery Tests--Three Simulation Studies

    Science.gov (United States)

    Wiberg, Marie

    2006-01-01

    A simulation study of a sequential computerized mastery test is carried out with items modeled with the 3 parameter logistic item response theory model. The examinees' responses are either identically distributed, not identically distributed, or not identically distributed together with estimation errors in the item characteristics. The…

  13. Computerized spirography and roentgenopneumopolygraphy in diagnosis of tracheobroncheal dyskinesia

    International Nuclear Information System (INIS)

    Gladkij, A.V.; Gul'ko, S.I.; Vyalyj, N.P.; Salivon, A.P.; Orlovskaya, I.I.

    1991-01-01

    The results of comprehensive examination of respiratory organs in 103 patients with hypotonic dyskinesia syndrome of trachea and large bronchi were presented. The comprehensive examination included computerized spirography and roentgenopneumopolygraphy with additional tests: exercise and drug. It was shown that the conducted comprehensive examination helped to receive an information about breathh physiology, to diagnose tracheobroncheal dyskinesia and to evaluate the degree of ventilation disorders

  14. Benefits of a relational database for computerized management

    International Nuclear Information System (INIS)

    Shepherd, W.W.

    1991-01-01

    This paper reports on a computerized relational database which is the basis for a hazardous materials information management system which is comprehensive, effective, flexible and efficient. The system includes product information for Material Safety Data Sheets (MSDSs), labels, shipping, and the environment and is used in Dowell Schlumberger (DS) operations worldwide for a number of programs including planning, training, emergency response and regulatory compliance

  15. Antipsychotic treatment in schizophrenia: the role of computerized neuropsychological assessment.

    Science.gov (United States)

    Kertzman, Semion; Reznik, Ilya; Grinspan, Haim; Weizman, Abraham; Kotler, Moshe

    2008-01-01

    The present study analyzes the role of neurocognitive assessment instruments in the detection of the contribution of antipsychotic treatment to cognitive functioning. Recently, a panel of experts suggested six main domains (working memory; attention/vigilance; verbal/visual learning and memory; reasoning and problem solving; speed of processing) implicated in schizophrenia-related cognitive deficits, which serve as a theoretical base for creation of real-time computerized neurocognitive batteries. The high sensitivity of computerized neuropsychological testing is based on their ability to adopt the reaction time (RT) paradigm for the assessment of brain function in a real-time regime. This testing is highly relevant for the monitoring of the cognitive effects of antipsychotics. Computerized assessment assists in the identification of state- and trait-related cognitive impairments. The optimal real-time computerized neurocognitive battery should composite balance between broad and narrow coverage of cognitive domains relevant to the beneficial effects of antipsychotics and will enable better planning of treatment and rehabilitation programs.

  16. 45 CFR 307.25 - Review and certification of computerized support enforcement systems.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES COMPUTERIZED SUPPORT ENFORCEMENT SYSTEMS § 307.25 Review and certification of computerized support enforcement systems. The Office will review, assess and inspect the... 45 Public Welfare 2 2010-10-01 2010-10-01 false Review and certification of computerized support...

  17. Morphological analysis of the vestibular aqueduct by computerized tomography images

    International Nuclear Information System (INIS)

    Marques, Sergio Ricardo; Smith, Ricardo Luiz; Isotani, Sadao; Alonso, Luis Garcia; Anadao, Carlos Augusto; Prates, Jose Carlos; Lederman, Henrique Manoel

    2007-01-01

    Objective: In the last two decades, advances in the computerized tomography (CT) field revise the internal and medium ear evaluation. Therefore, the aim of this study is to analyze the morphology and morphometric aspects of the vestibular aqueduct on the basis of computerized tomography images (CTI). Material and method: Computerized tomography images of vestibular aqueducts were acquired from patients (n = 110) with an age range of 1-92 years. Thereafter, from the vestibular aqueducts images a morphometric analysis was performed. Through a computerized image processing system, the vestibular aqueduct measurements comprised of its area, external opening, length and the distance from the vestibular aqueduct to the internal acoustic meatus. Results: The morphology of the vestibular aqueduct may be funnel-shaped, filiform or tubular and the respective proportions were found to be at 44%, 33% and 22% in children and 21.7%, 53.3% and 25% in adults. The morphometric data showed to be of 4.86 mm 2 of area, 2.24 mm of the external opening, 4.73 mm of length and 11.88 mm of the distance from the vestibular aqueduct to the internal acoustic meatus, in children, and in adults it was of 4.93 mm 2 , 2.09 mm, 4.44 mm, and 11.35 mm, respectively. Conclusions: Computerized tomography showed that the vestibular aqueduct presents high morphological variability. The morphometric analysis showed that the differences found between groups of children and adults or between groups of both genders were not statistically significant

  18. Necrotizing RPGN with linear anti IgG deposits in a patient with history of granulomatosis with polyangiitis: a case report

    Directory of Open Access Journals (Sweden)

    Parekh N

    2014-11-01

    Full Text Available Ninad Parekh, Edward Epstein, Suzanne El-Sayegh Department of Medicine, Division of Nephrology, Staten Island University Hospital, Staten Island, NY, USA Introduction: Diagnosing the etiology of a rapidly progressive glomerulonephritis is of vital importance to guide appropriate therapeutic management. This case highlights the complexity involved in establishing diagnosis when presentation is atypical. In certain cases diagnosis cannot be established based on clinical presentation or biopsy findings alone, and critical analysis of biopsy findings in context of clinical presentation is crucial to guide the clinical decision-making process.Case presentation: A 47-year-old Hispanic male with history of granulomatosis with polyangiitis (GPA in remission on azathioprine, presented with fatigue and lethargy. Physical examination was unremarkable. Laboratory data revealed elevated creatinine and otherwise normal electrolytes. Urinalysis showed numerous dysmorphic red blood cells with few red cell casts. His serologic results were all negative except anti-proteinase-3 antibody at very low titers. Kidney biopsy showed necrotizing crescentic glomerulonephritis with linear immunoglobulin G staining along the basement membrane.Conclusion: This case presented conflicting serologic and histopathologic findings. The presence of anti-proteinase-3 antibody supported diagnosis of recurrence of GPA. However, linear staining of immunoglobulin G (IgG on immunofluorescence (IF staining of renal biopsy supported anti-glomerular basement membrane (GBM disease. The treatment of anti-GBM disease and GPA both involve immunosuppression with prednisone and cyclophosphamide. However, patients with anti-GBM disease are also treated with plasmapheresis early in the disease presentation to prevent further damage. The patient with GPA, on the other hand, was shown to benefit from plasmapheresis only in the case of severe renal disease (serum creatinine level more than 5 mg/dL or

  19. Validation of the computerized annunciation message list system (CAMLS)

    Energy Technology Data Exchange (ETDEWEB)

    Feher, M P; Davey, E C; Lupton, L R [AECL, Chalk River Labs., Chalk River, ON (Canada)

    1997-09-01

    The Computerized Annunciation Message List System is a computerized annunciation system for the control rooms of nuclear generating stations. CAMLS will alert operators to changes in plant conditions that may impact on safety and production and help staff to effectively respond. CAMLS is designed to: provide a clear and concise overview of the current problems or faults in the plant; provide an overview of the current state of the plant in terms of automatic process and equipment actions; provide support for specific operational tasks, through either pre-configured or operator-configured annunciation displays, including: rapid and efficient upset response, plant stabilization, problem diagnosis, recovery action planning and implementation, and rapid recovery from trip and return to power operation. To achieve this, several information processing, presentation,a nd interaction concepts were developed. 2 refs, 6 figs, 7 tabs.

  20. Computerized tomography in diffuse diseases of the liver. Pt. 2

    International Nuclear Information System (INIS)

    Helmberger, H.; Vogel, U.; Bautz, W.

    1993-01-01

    Computerized tomography is a first-line method of imaging to confirm diffuse disorders of the liver suggested by preliminary clinical and biochemical findings. If the disease is caused by an obstructed vessel, this is reliably detected. For most types of thesaurismosis as well as hepatic steatosis and cirrhosis of the liver approaches to quantitative determinations of the spread of disease have been described in theory but so far failed to show great merits in practice. The transition from hepatic fibrosis to cirrhosis as the final developmental stage common to all those disorders has typical features on computerized tomography. This explains why the use of this method in diffuse hepatic disease offers particular advantages as regards the detection of complications occurring at an advanced stage ot the diagnosis of changes developing into malignancies. (orig.) [de

  1. Computerized axial tomography : the tool in osseointegrated dental implants

    International Nuclear Information System (INIS)

    Fernandez-Lopez, Otton

    2002-01-01

    Failure rates in rehabilitations with osseointegrated implants are handled through appropriate radiographic preoperative planning. The appropriate length of the implant without running the risk of a perforation of vital structures, has been determined by a radiographic diagnosis. Computerized and conventional axial tomography have proved to be invaluable elements for pre-surgical evaluation. A radiologic guidance is elaborated to perform a computerized axial tomography (CT) of maxillary bones in totally edentulous patients. Surgical guides are constructed from a wax-up emanated from the information of the CT. The CT has proven to be an radiographic indispensable element to achieve the surgical-prosthetic success in osseointegrated dental implants. The CT has allowed the realization of a precise wax-up for making of surgical guide and a precise temporary prostheses in positioning of osseointegrated implants, with the consequent saving time and money for the rehabilitator and patient [es

  2. Computerized reactor monitor and control for nuclear reactors

    International Nuclear Information System (INIS)

    Buerger, L.

    1982-01-01

    The analysis of a computerized process control system developed by Transelektro-KFKI-Videoton (Hangary) for a twenty-year-old research reactor in Budapest and or a new one in Tajura (Libya) is given. The paper describes the computer hardware (R-10) and the implemented software (PROCESS-24K) as well as their applications at nuclear reactors. The computer program provides for man-machine communication, data acquisition and processing, trend and alarm analysis, the control of the reactor power, reactor physical calculations and additional operational functions. The reliability and the possible further development of the computerized systems which are suitable for application at reactors of different design are also discussed. (Sz.J.)

  3. Transformations and algorithms in a computerized brain atlas

    International Nuclear Information System (INIS)

    Thurfjell, L.; Bohm, C.; Eriksson, L.; Karolinska Institute/Hospital, Stockholm

    1993-01-01

    The computerized brain atlas constructed at the Karolinska Hospital, Stockholm, Sweden, has been further developed. This atlas was designed to be employed in different fields of neuro imaging such as positron emission tomography (PET), single photon emission tomography (SPECT), computerized tomography (CT) and magnetic resonance imaging (MR). The main objectives with the atlas is to aid the interpretation of functional images by introducing anatomical information, to serve as a tool in the merging of data from different imaging modalities and to facilitate the comparisons of data from different individuals by allowing for anatomical standardization of individual data. The purpose of this paper is to describe the algorithms and transformations used in the implementation of the atlas software

  4. Computerized Tests. New practical and ethical challenges for Psychological Assessment

    Directory of Open Access Journals (Sweden)

    Gabriela Susana Lozzia

    2013-08-01

    Full Text Available The purpose of this study is to bring the readers in our field of knowledge closer to the new problems and solutions resulting from the application of computer systems to Psychological Assessment. Therefore, this work puts forward a suitable implementation of Computer-based and Internet-delivered Testing, includes a description of the new technologies that can be applied to Psychological Assessment: administration of traditional paper-and-pencil tests through computers, elaboration of automated reports, computerized adaptive tests, automated test construction and automatic generation of items, as well as the specific guidelines and regulations governing the development of each of these areas. This study provides an outline of the current issues connected with the appropriate use of Computerized Tests by way of conclusion and finally encourages psychologists to keep debating and reflecting on these topics.

  5. Prognosis of the computerized tomography in the severe head injury

    International Nuclear Information System (INIS)

    Garcia-Nieto, J.J.; Lorenzo Dominguez, M.T.; Martin Sanchez, M.J.; Sanchez Gonzalez, E.

    1991-01-01

    A prospective study is made with sixty five people affected of severe head injury, that is to say, with eight or less points in the Glasgow Coma Scale (GCS), when they get to the hospital. They are studied by computerized tomography at the income, but also, three and seven days after arriving. In this way, we appraise the type of the lesion the intensity and the possible effect-wass, considering in the last case, three features: a) ventricular collapse; b) the mean line structure s shift; c) perimesencefalic cisterns affectation. The findings of this study, are parametized and we were able to introduce them into a computer, getting. The relations between these findings ands the end-results. These last ones appraised throungh the Glasgow Outcome Scale (GOS). We could confirm, that certain findings in the computerized tomography have and unavoidable prognosis, where as others have a better prognosis. (Author)

  6. Algorithms for Computerized Fetal Heart Rate Diagnosis with Direct Reporting

    Directory of Open Access Journals (Sweden)

    Kazuo Maeda

    2015-06-01

    Full Text Available Aims: Since pattern classification of fetal heart rate (FHR was subjective and enlarged interobserver difference, objective FHR analysis was achieved with computerized FHR diagnosis. Methods: The computer algorithm was composed of an experts’ knowledge system, including FHR analysis and FHR score calculation, and also of an objective artificial neural network system with software. In addition, a FHR frequency spectrum was studied to detect ominous sinusoidal FHR and the loss of baseline variability related to fetal brain damage. The algorithms were installed in a central-computerized automatic FHR monitoring system, which gave the diagnosis rapidly and directly to the attending doctor. Results: Clinically perinatal mortality decreased significantly and no cerebral palsy developed after introduction of the centralized system. Conclusion: The automatic multichannel FHR monitoring system improved the monitoring, increased the objectivity of FHR diagnosis and promoted clinical results.

  7. Method of evaluation of diagnostics reference levels in computerized tomography

    International Nuclear Information System (INIS)

    Vega, Walter Flores

    1999-04-01

    Computerized tomography is a complex technique with several selectable exposition parameters delivering high doses to the patient. In this work it was developed a simple methodology to evaluate diagnostic reference levels in computerized tomography, using the concept of Multiple Scan Average Dose (MSAD), recently adopted by the Health Ministry. For evaluation of the MSAD, a dose distribution was obtained through a measured dose profile on the axial axis of a water phantom with thermoluminescence dosemeters, TLD-100, for different exam technique. The MSAD was evaluated hrough two distinct methods. First, it was evaluated by the integration of the dose profile of a single slice and, second, obtained by the integration on central slice of the profile of several slices. The latter is in of accordance with the ionization chamber method, suggesting to be the most practical method of dose evaluation to be applied in the diagnostic reference level assessment routine for CT, using TLDs. (author)

  8. Computerized operation manual (COM) of nuclear power plants

    International Nuclear Information System (INIS)

    Szegi, Z.

    1985-01-01

    This paper is to be presented at the International Seminar on Diagnoses of and Response to Abnormal Occurrences at Nuclear Power Plants organized by the International Atomic Energy Agency. The topic of presentation is the Computerized Operational Manual. This system supports the operator at disturbance situations by displaying quickly and unambiguously the operational instructions and the relevant information without mistakes. By the computerized manual the operator can determine the instruction-subsystem which reflects the real state of the power unit. From this point the system guides the operator on how to drive the unit to another determined state by providing the operational instructions at any time. A data bank is also included which contains information concerning rules restricting on maintenance and repair. The system will be realized at Paks NPP. (author)

  9. A three-dimensional computerized isometric strength measurement system.

    Science.gov (United States)

    Black, Nancy L; Das, Biman

    2007-05-01

    The three-dimensional Computerized Isometric Strength Measurement System (CISMS) reliably and accurately measures isometric pull and push strengths in work spaces of paraplegic populations while anticipating comparative studies with other populations. The main elements of the system were: an extendable arm, a vertical supporting track, a rotating platform, a force transducer, stability sensors and a computerized data collection interface. The CISMS with minor modification was successfully used to measure isometric push-up and pull-down strengths of paraplegics and isometric push, pull, push-up and pull-down strength in work spaces for seated and standing able-bodied populations. The instrument has satisfied criteria of versatility, safety and comfort, ease of operation, and durability. Results are accurate within 2N for aligned forces. Costing approximately $1,500 (US) including computer, the system is affordable and accurate for aligned isometric strength measurements.

  10. Validation of the computerized annunciation message list system (CAMLS)

    International Nuclear Information System (INIS)

    Feher, M.P.; Davey, E.C.; Lupton, L.R.

    1997-01-01

    The Computerized Annunciation Message List System is a computerized annunciation system for the control rooms of nuclear generating stations. CAMLS will alert operators to changes in plant conditions that may impact on safety and production and help staff to effectively respond. CAMLS is designed to: provide a clear and concise overview of the current problems or faults in the plant; provide an overview of the current state of the plant in terms of automatic process and equipment actions; provide support for specific operational tasks, through either pre-configured or operator-configured annunciation displays, including: rapid and efficient upset response, plant stabilization, problem diagnosis, recovery action planning and implementation, and rapid recovery from trip and return to power operation. To achieve this, several information processing, presentation,a nd interaction concepts were developed. 2 refs, 6 figs, 7 tabs

  11. Computerized health information and the demand for medical care.

    Science.gov (United States)

    Wagner, Todd H; Jimison, Holly B

    2003-01-01

    Consumer health information, once the domain of books and booklets, has become increasingly digitized and available on the Internet. This study assessed the effect of using computerized health information on consumers' demand for medical care. The dependent variable was self-reported number of visits to the doctor in the past year. The key independent variable was the use of computerized health information, which was treated as endogenous. We tested the effect of using computerized health information on physician visits using ordinary least squares, instrumental variables, fixed effects, and fixed-effects instrumental variables models. The instrumental variables included exposure to the Healthwise Communities Project, a community-wide health information intervention; computer ownership; and Internet access. Random households in three cities were mailed questionnaires before and after the Healthwise Communities Project. In total, 5909 surveys were collected for a response rate of 54%. In both the bivariate and the multivariate analyses, the use of computerized health information was not associated with self-reported entry into care or number of visits. The instrumental variables models also found no differences, with the exception that the probability of entering care was significantly greater with the two-stage conditional logit model (P information is intuitively appealing, we found little evidence of an association between using a computer for health information and self-reported medical visits in the past year. This study used overall self-reported utilizations as the dependent variable, and more research is needed to determine whether health information affects the health production function in other important ways, such as the location of care, the timing of getting care, or the intensity of treatment.

  12. Status of computerization and application in nuclear reactors

    International Nuclear Information System (INIS)

    Viedma, L.G. de

    1997-01-01

    The CSN has recently procured a latest generation computer to address its future design requirements. In order to present it to the readers, this articles sets out the concepts of the latest computerization technologies, making historical references to the evolution of the different architectures and different computers with similar performance available on the market. Mention is also made to areas where parallel design is, or may be, highly important in the future. (Author)

  13. Computerization of operation and maintenance for nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    This report provides a resource for computerization of activities in plant operation and maintenance. Experience gained from design and implementation of various computer systems around the world is described. The material may be useful as a guide to modification and upgrading of existing plants as well as design and engineering of new plants. It should be particularly of interest to managers and engineers who are engaged in planning, bidding, specifying or designing computer systems for operation and maintenance applications. Refs, figs and tabs.

  14. Laboratory Computerization: The Case for a Prospective Analysis

    OpenAIRE

    Hurdle, John F.; Schwamm, Harry A.

    1982-01-01

    The argument is made that computerization of a laboratory should be preceeded by a thorough prospective analysis of laboratory operations. Points to be pondered include complementation of retrospective data, system cost justification, system performance justification, post-installation personnel adjustments, improved system utilization, improved manual performance, and insight into “how much” system to buy. A brief, general outline is offered describing how to approach such a study.

  15. Computerization of operation and maintenance for nuclear power plants

    International Nuclear Information System (INIS)

    1995-07-01

    This report provides a resource for computerization of activities in plant operation and maintenance. Experience gained from design and implementation of various computer systems around the world is described. The material may be useful as a guide to modification and upgrading of existing plants as well as design and engineering of new plants. It should be particularly of interest to managers and engineers who are engaged in planning, bidding, specifying or designing computer systems for operation and maintenance applications. Refs, figs and tabs

  16. Computerized radiation control system in the Chernobyl 30-km zone

    International Nuclear Information System (INIS)

    Vasil'chenko, D.L.; Pis'mak, A.D.; Livertovskij, G.P.; Chikhladze, V.S.

    1992-01-01

    Computerized radiation control system is intended for monitoring radiation in the zone of radiation-hazardous objects for providing nuclear power station services with current information on radiactive situation in the zone of observation and the doses of radiation taken by the personnel. Described are tasks and functions of the system, as well as its structure. It is noted that unique conditions of the Chernobyl' 30-km zone open up opportunities for experiments and testing new models of equipment. 2 figs

  17. Dosimetry of computerized tomography in the evaluation of hip dysplasia

    Energy Technology Data Exchange (ETDEWEB)

    Guyer, B.; Bassano, D.A.; Levinsohn, E.M.; Smith, D.S.; Cady, R.B.

    1984-07-01

    The usefulness of computerized tomography (CT) in the assessment of hip dysplasia has recently been given attention in the literature and concern regarding radiation dose has been raised. This study was undertaken to measure the radiation dose, both in and out of plaster, for plain films, arthrography, tomography, and CT. A method is suggested to reduce dosage by 80% without compromising diagnostic information. Our experience with 25 scans of patients aged 4 months to 39 years is presented.

  18. Preoperative localization of parathyroid tumor by computerized tomography

    International Nuclear Information System (INIS)

    Kan, Seiji; Hiraishi, Koji; Nakamura, Shoichiro; Yamamoto, Schuzo; Odachi, Motoaki; Yamashita, Toshiyuki.

    1984-01-01

    Five patients of primary hyperparathyroidism with urolithiasis underwent CT-scanning for the preoperative localization of parathyroid tumor. The tumor was identified in all patients but one, who had a multiple adenomatous goiter. In this case, postoperative observation of the CT-scan revealed the parathyroid tumor. It appears that if the size of the parathyroid tumor is about 1cm in diameter, there is a high possibility of preoperative localization by computerized tomography. (author)

  19. A Framework for the Development of Computerized Adaptive Tests

    Directory of Open Access Journals (Sweden)

    Nathan A. Thompson

    2011-01-01

    Full Text Available A substantial amount of research has been conducted over the past 40 years on technical aspects of computerized adaptive testing (CAT, such as item selection algorithms, item exposure controls, and termination criteria. However, there is little literature providing practical guidance on the development of a CAT. This paper seeks to collate some of the available research methodologies into a general framework for the development of any CAT assessment.

  20. Carolina Power and Light Company's computerized Radiological Information Management System

    International Nuclear Information System (INIS)

    Meyer, B.A.

    1987-01-01

    Carolina Power and Lignt Company has recently implement a new version of their computerized Radiological Information management System. The new version was programmed in-house and is run on the Company's mainframe computers. In addition to providing radiation worker dose histories and current dose updates, the system provides real-time access control for all three of the Company's nuclear plants such as respirator and survey equipment control and inventory, TLD QC records, and many other functions

  1. Strategy generator in computerized accident management support system

    International Nuclear Information System (INIS)

    Sirola, M.

    1994-02-01

    An increased interest for research in the field of accident management of nuclear power plants can be noted. Several international programmes have been started in order to be able to understand the basic physical and chemical phenomena in accident conditions. A feasibility study has shown that it would be possible to design and develop a computerized support system for plant staff in accident situations. To achieve this goal the Halden Project has initiated a research programme on Computerized Accident Management Support (CAMS project). The aim is to utilize the capabilities of computerized tools to support the plant staff during the various accident stages. The system will include identification of the accident state, assessment of the future development of the accident and planning of accident mitigation strategies. A prototype is developed to support operators and the Technical Support Centre in decision making during serious accidents in nuclear power plants. A rule based system has been built to take care of the strategy generation. This system assists plant personnel in planning control proposals and mitigation strategies from normal operation to severe accident conditions. The idea of a safety objective tree and knowledge from the emergency procedures have been used. Future prediction requires good state identification of the plant status and some knowledge about the history of some critical variables. The information needs to be validated as well. Accurate calculations in simulators and a large database including all important information from the plant will help the strategy planning. (orig.). (40 refs., 20 figs.)

  2. Safety implications of computerized process control in nuclear power plants

    International Nuclear Information System (INIS)

    1991-02-01

    Modern nuclear power plants are making increasing use of computerized process control because of the number of potential benefits that accrue. This practice not only applies to new plants but also to those in operation. Here, the replacement of both conventional process control systems and outdated computerized systems is seen to be of benefit. Whilst this contribution is obviously of great importance to the viability of nuclear electricity generation, it must be recognized that there are major safety concerns in taking this route. However, there is the potential for enhancing the safety of nuclear power plants if the full power of microcomputers and the associated electronics is applied correctly through well designed, engineered, installed and maintained systems. It is essential that areas where safety can be improved be identified and that the pitfalls are clearly marked so that they can be avoided. The deliberations of this Technical Committee Meeting are a step on the road to this goal of improved safety through computerized process control. This report also contains the papers presented at the technical committee meeting by participants. A separate abstract was prepared for each of these 15 presentations. Refs, figs and tabs

  3. AUTOMATIC ESTIMATION OF SIZE PARAMETERS USING VERIFIED COMPUTERIZED STEREOANALYSIS

    Directory of Open Access Journals (Sweden)

    Peter R Mouton

    2011-05-01

    Full Text Available State-of-the-art computerized stereology systems combine high-resolution video microscopy and hardwaresoftware integration with stereological methods to assist users in quantifying multidimensional parameters of importance to biomedical research, including volume, surface area, length, number, their variation and spatial distribution. The requirement for constant interactions between a trained, non-expert user and the targeted features of interest currently limits the throughput efficiency of these systems. To address this issue we developed a novel approach for automatic stereological analysis of 2-D images, Verified Computerized Stereoanalysis (VCS. The VCS approach minimizes the need for user interactions with high contrast [high signal-to-noise ratio (S:N] biological objects of interest. Performance testing of the VCS approach confirmed dramatic increases in the efficiency of total object volume (size estimation, without a loss of accuracy or precision compared to conventional computerized stereology. The broad application of high efficiency VCS to high-contrast biological objects on tissue sections could reduce labor costs, enhance hypothesis testing, and accelerate the progress of biomedical research focused on improvements in health and the management of disease.

  4. Effect of gender on computerized electrocardiogram measurements in college athletes.

    Science.gov (United States)

    Mandic, Sandra; Fonda, Holly; Dewey, Frederick; Le, Vy-van; Stein, Ricardo; Wheeler, Matt; Ashley, Euan A; Myers, Jonathan; Froelicher, Victor F

    2010-06-01

    Broad criteria for classifying an electrocardiogram (ECG) as abnormal and requiring additional testing prior to participating in competitive athletics have been recommended for the preparticipation examination (PPE) of athletes. Because these criteria have not considered gender differences, we examined the effect of gender on the computerized ECG measurements obtained on Stanford student athletes. Currently available computer programs require a basis for "normal" in athletes of both genders to provide reliable interpretation. During the 2007 PPE, computerized ECGs were recorded and analyzed on 658 athletes (54% male; mean age, 19 +/- 1 years) representing 22 sports. Electrocardiogram measurements included intervals and durations in all 12 leads to calculate 12-lead voltage sums, QRS amplitude and QRS area, spatial vector length (SVL), and the sum of the R wave in V5 and S wave in V2 (RSsum). By computer analysis, male athletes had significantly greater QRS duration, PR interval, Q-wave duration, J-point amplitude, and T-wave amplitude, and shorter QTc interval compared with female athletes (all P < 0.05). All ECG indicators of left ventricular electrical activity were significantly greater in males. Although gender was consistently associated with indices of atrial and ventricular electrical activity in multivariable analysis, ECG measurements correlated poorly with body dimensions. Significant gender differences exist in ECG measurements of college athletes that are not explained by differences in body size. Our tables of "normal" computerized gender-specific measurements can facilitate the development of automated ECG interpretation for screening young athletes.

  5. Computerized tomography of kidneys in long-term dialysis patients

    International Nuclear Information System (INIS)

    Srp, A.; Merta, M.; Sulkova, S.

    1990-01-01

    A cohort is presented of 21 patients with irreversible kidney failure who were examined by computerized tomography in 1986-1987. The mean period of dialysis programme was 5.7 years, chronic glomerulonephritis and interstitial nephritis were the basic conditions. According to the results of computerized tomography, the patients were divided into four groups: 1. the presence of cysts or tumors was not established, 2. multiplecysts were found in bilateral location, 3. less than 3 cysts were found, 4. kidney tumor was diagnosed. The factor causing the development of the cysts was not identified. It is presumed that the disease is caused by a biologically active substance which is not efficiently dialyzed. The examination of the kidneys is recommended in patients in the stage of chronic kidney insufficiency and particularly in patients on dialysis for a long period of time. The recommended examination uses computerized tomography, and attention should be given to the possible occurence of acquired cystic disease or kidney tumors. (author). 6 figs., 8 refs

  6. Nuclear Computerized Library for Assessing Reactor Risk (NUCLARR)

    International Nuclear Information System (INIS)

    Gilmore, W.E.; Blackman, H.S.; Ryan, T.G.

    1986-01-01

    The Nuclear Computerized Library for Assessing Reactor Risk (NUCLARR) program is a multiyear effort sponsored by the NRC and is being conducted at the Idaho National Engineering Laboratory (INEL). The goal of this program is to establish and operate computerized data base management tools for the human reliability data bank specification developed by Comer and Donovan. The NRC and the risk analysis community recognized that implementing a fully functional library would not be feasible, or practical, without the aid of computerized tools for management and manipulation of its data sources. The end users of the NUCLARR can be classified into three categories according to specific needs. The first category is those users interested in reviewing individual data sources for a given situation. The second category of users selects multiple data sources for a specific case, summarizing the information, and performing comparative studies. The last category of users interfaces the NUCLARR with other programming applications, such as other data banks, and simulation models of risk assessment. Project status is provided in the paper

  7. Work improvement by computerizing the process of shielding block production

    International Nuclear Information System (INIS)

    Kang, Dong Hyuk; Jeong, Do Hyeong; Kang, Dong Yoon; Jeon, Young Gung; Hwang, Jae Woong

    2013-01-01

    Introducing CR (Computed Radiography) system created a process of printing therapy irradiation images and converting the degree of enlargement. This is to increase job efficiency and contribute to work improvement using a computerized method with home grown software to simplify this process, work efficiency. Microsoft EXCEL (ver. 2007) and VISUAL BASIC (ver. 6.0) have been used to make the software. A window for each shield block was designed to enter patients' treatment information. Distances on the digital images were measured, the measured data were entered to the Excel program to calculate the degree of enlargement, and printouts were produced to manufacture shield blocks. By computerizing the existing method with this program, the degree of enlargement can easily be calculated and patients' treatment information can be entered into the printouts by using macro function. As a result, errors in calculation which may occur during the process of production or errors that the treatment information may be delivered wrongly can be reduced. In addition, with the simplification of the conversion process of the degree of enlargement, no copy machine was needed, which resulted in the reduction of use of paper. Works have been improved by computerizing the process of block production and applying it to practice which would simplify the existing method. This software can apply to and improve the actual conditions of each hospital in various ways using various features of EXCEL and VISUAL BASIC which has already been proven and used widely

  8. Work improvement by computerizing the process of shielding block production

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Dong Hyuk; Jeong, Do Hyeong; Kang, Dong Yoon; Jeon, Young Gung; Hwang, Jae Woong [Proton Therapy Center, National Cancer Center, Goyang (Korea, Republic of)

    2013-09-15

    Introducing CR (Computed Radiography) system created a process of printing therapy irradiation images and converting the degree of enlargement. This is to increase job efficiency and contribute to work improvement using a computerized method with home grown software to simplify this process, work efficiency. Microsoft EXCEL (ver. 2007) and VISUAL BASIC (ver. 6.0) have been used to make the software. A window for each shield block was designed to enter patients' treatment information. Distances on the digital images were measured, the measured data were entered to the Excel program to calculate the degree of enlargement, and printouts were produced to manufacture shield blocks. By computerizing the existing method with this program, the degree of enlargement can easily be calculated and patients' treatment information can be entered into the printouts by using macro function. As a result, errors in calculation which may occur during the process of production or errors that the treatment information may be delivered wrongly can be reduced. In addition, with the simplification of the conversion process of the degree of enlargement, no copy machine was needed, which resulted in the reduction of use of paper. Works have been improved by computerizing the process of block production and applying it to practice which would simplify the existing method. This software can apply to and improve the actual conditions of each hospital in various ways using various features of EXCEL and VISUAL BASIC which has already been proven and used widely.

  9. Comparison between visual and computerized cardiotocography in low risk pregnancy

    International Nuclear Information System (INIS)

    Mirghani, Hisham M.; Khair, Howaida

    2005-01-01

    To compare between visual and computerized cardiotocography (cCTG) in low-risk pregnant women in predicting pregnancy outcome. One hundred and fifty-three consecutive computerized fetal heart tracings were recorded from non-laboring pregnant women at >/- 30 weeks gestation. All traces were reviewed by 2 experienced obstetricians. The study was carried out at Al-Ain Medical District, United Arab Emirates, between August 2004 and December 2004. Of the 153 pregnant women, 11 (7.2%) were delivered by cesarean section. The interobserver agreement was 0.60. The observers cCTG agreement were 0.48 and 0.45. The difference in cesarean section rate was not statistically significant. Observers interpretation and cCTG did not correlate well with Apgar score at 5 minutes and admission to special care baby unit. Computerized CTG has little advantage over conventional CTG in the prediction of Apgar score and need for neonatal intensive care unit admission in a low-risk population. (author)

  10. A case of neurosarcoidosis monitored by computerized tomography

    International Nuclear Information System (INIS)

    Kubota, Toshihiko; Kimura, Makoto; Komai, Toshio; Yamamoto, Shinjiro; Yamamura, Itaru

    1979-01-01

    A 21-year-old man complaining of impaired visual acuity was admitted to the hospital. Physical examinations showed asymptomatic bilateral hilar lymphadenopathy and cardiomyopathy. Neurological findings disclosed left blindness and right temporal hemianopsia. Computerized tomography, pneumoencephalography and carotid angiography revealed a suprasellar mass. After the admission, the following symptoms deteriorated rapidly: diabetes insipidus, anterior pituitary dysfunction, visual loss of the right eye and hepatomegaly, subsequently consciousness disorder developed during a month though he was given steroids. The more deteriorated the clinical course, the larger the suprasellar mass with expanding hydrocephalus in repeated computerized tomographies. After the ventriculo-peritoneal shunt operation, consciousness improved. Diabetes insipidus also improved after Diabenese administration. On the operation, adhesive arachnoiditis over all the frontotemporal cortex and swollen purplishly red optic chiasm were exposed. Microscopically the specimen from the optic chiasm evidenced a sarcoid granuloma which composed of epitheroid cells, lymphocytes and multi-nucleated giant cells with numerous hemosiderin droplets. The specimen from the surface of the left frontal lobe showed thick fibrosis in the subarachnoid space. By steroids therapy, diabetes insipidus and hepatomegaly disappeared five months after the admission, whereas blindness never recovered. He died of developed status epilepticus eleven months after the admission. The authors reviewed neuroradiological findings of neurocarcoidosis based on pathological findings in the literature, and emphasized that computerized tomography was the most useful for diagnosis and treatment of neurosarcoidosis. (author)

  11. Computerized Respiratory Sounds: Novel Outcomes for Pulmonary Rehabilitation in COPD.

    Science.gov (United States)

    Jácome, Cristina; Marques, Alda

    2017-02-01

    Computerized respiratory sounds are a simple and noninvasive measure to assess lung function. Nevertheless, their potential to detect changes after pulmonary rehabilitation (PR) is unknown and needs clarification if respiratory acoustics are to be used in clinical practice. Thus, this study investigated the short- and mid-term effects of PR on computerized respiratory sounds in subjects with COPD. Forty-one subjects with COPD completed a 12-week PR program and a 3-month follow-up. Secondary outcome measures included dyspnea, self-reported sputum, FEV 1 , exercise tolerance, self-reported physical activity, health-related quality of life, and peripheral muscle strength. Computerized respiratory sounds, the primary outcomes, were recorded at right/left posterior chest using 2 stethoscopes. Air flow was recorded with a pneumotachograph. Normal respiratory sounds, crackles, and wheezes were analyzed with validated algorithms. There was a significant effect over time in all secondary outcomes, with the exception of FEV 1 and of the impact domain of the St George Respiratory Questionnaire. Inspiratory and expiratory median frequencies of normal respiratory sounds in the 100-300 Hz band were significantly lower immediately (-2.3 Hz [95% CI -4 to -0.7] and -1.9 Hz [95% CI -3.3 to -0.5]) and at 3 months (-2.1 Hz [95% CI -3.6 to -0.7] and -2 Hz [95% CI -3.6 to -0.5]) post-PR. The mean number of expiratory crackles (-0.8, 95% CI -1.3 to -0.3) and inspiratory wheeze occupation rate (median 5.9 vs 0) were significantly lower immediately post-PR. Computerized respiratory sounds were sensitive to short- and mid-term effects of PR in subjects with COPD. These findings are encouraging for the clinical use of respiratory acoustics. Future research is needed to strengthen these findings and explore the potential of computerized respiratory sounds to assess the effectiveness of other clinical interventions in COPD. Copyright © 2017 by Daedalus Enterprises.

  12. MDCT for computerized volumetry of pneumothoraces in pediatric patients.

    Science.gov (United States)

    Cai, Wenli; Lee, Edward Y; Vij, Abhinav; Mahmood, Soran A; Yoshida, Hiroyuki

    2011-03-01

    Our purpose in this study was to develop an automated computer-aided volumetry (CAV) scheme for quantifying pneumothorax in multidetector computed tomography (MDCT) images for pediatric patients and to investigate the imaging parameters that may affect its accuracy. Fifty-eight consecutive pediatric patients (mean age 12 ± 6 years) with pneumothorax who underwent MDCT for evaluation were collected retrospectively for this study. All cases were imaged by a 16- or 64-MDCT scanner with weight-based kilovoltage, low-dose tube current, 1.0-1.5 pitch, 0.6-5.0 mm slice thickness, and a B70f (sharp) or B31f (soft) reconstruction kernel. Sixty-three pneumothoraces ≥1 mL were visually identified in the left (n = 30) and right (n = 33) lungs. Each identified pneumothorax was contoured manually on an Amira workstation V4.1.1 (Mercury Computer Systems, Chelmsford, MA) by two radiologists in consensus. The computerized volumes of the pneumothoraces were determined by application of our CAV scheme. The accuracy of our automated CAV scheme was evaluated by comparison between computerized volumetry and manual volumetry, for the total volume of pneumothoraces in the left and right lungs. The mean difference between the computerized volumetry and the manual volumetry for all 63 pneumothoraces ≥1 mL was 8.2%. For pneumothoraces ≥10 mL, ≥50 mL, and ≥200 mL, the mean differences were 7.7% (n = 57), 7.3% (n = 33), and 6.4% (n = 13), respectively. The correlation coefficient was 0.99 between the computerized volume and the manual volume of pneumothoraces. Bland-Altman analysis showed that computerized volumetry has a mean difference of -5.1% compared to manual volumetry. For all pneumothoraces ≥10 mL, the mean differences for slice thickness ≤1.25 mm, = 1.5 mm, and = 5.0 mm were 6.1% (n = 28), 3.5% (n = 10), and 12.2% (n = 19), respectively. For the two reconstruction kernels, B70f and B31f, the mean differences were 6.3% (n = 42, B70f) and 11.7% (n = 15, B31f

  13. Reflecting on the ethical administration of computerized medical records

    Science.gov (United States)

    Collmann, Jeff R.

    1995-05-01

    This presentation examines the ethical issues raised by computerized image management and communication systems (IMAC), the ethical principals that should guide development of policies, procedures and practices for IMACS systems, and who should be involved in developing a hospital's approach to these issues. The ready access of computerized records creates special hazards of which hospitals must beware. Hospitals must maintain confidentiality of patient's records while making records available to authorized users as efficiently as possible. The general conditions of contemporary health care undermine protecting the confidentiality of patient record. Patients may not provide health care institutions with information about themselves under conditions of informed consent. The field of information science must design sophisticated systems of computer security that stratify access, create audit trails on data changes and system use, safeguard patient data from corruption, and protect the databases from outside invasion. Radiology professionals must both work with information science experts in their own hospitals to create institutional safeguards and include the adequacy of security measures as a criterion for evaluating PACS systems. New policies and procedures on maintaining computerized patient records must be developed that obligate all members of the health care staff, not just care givers. Patients must be informed about the existence of computerized medical records, the rules and practices that govern their dissemination and given the opportunity to give or withhold consent for their use. Departmental and hospital policies on confidentiality should be reviewed to determine if revisions are necessary to manage computer-based records. Well developed discussions of the ethical principles and administrative policies on confidentiality and informed consent and of the risks posed by computer-based patient records systems should be included in initial and continuing

  14. Revisiting the systemic vasculitis in eosinophilic granulomatosis with polyangiitis (Churg-Strauss): A study of 157 patients by the Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires and the European Respiratory Society Taskforce on eosinophilic granulomatosis with polyangiitis (Churg-Strauss).

    Science.gov (United States)

    Cottin, Vincent; Bel, Elisabeth; Bottero, Paolo; Dalhoff, Klaus; Humbert, Marc; Lazor, Romain; Sinico, Renato A; Sivasothy, Pasupathy; Wechsler, Michael E; Groh, Matthieu; Marchand-Adam, Sylvain; Khouatra, Chahéra; Wallaert, Benoit; Taillé, Camille; Delaval, Philippe; Cadranel, Jacques; Bonniaud, Philippe; Prévot, Grégoire; Hirschi, Sandrine; Gondouin, Anne; Dunogué, Bertrand; Chatté, Gérard; Briault, Christophe; Pagnoux, Christian; Jayne, David; Guillevin, Loïc; Cordier, Jean-François

    2017-01-01

    To guide nosology and classification of patients with eosinophilic granulomatosis with polyangiitis (EGPA) based on phenotype and presence or absence of ANCA. Organ manifestations and ANCA status were retrospectively analyzed based on the presence or not of predefined definite vasculitis features or surrogates of vasculitis in patients asthma, eosinophilia, and at least one systemic organ manifestation attributable to systemic disease. The study population included 157 patients (mean age 49.4±14.1), with a follow-up of 7.4±6.4years. Patients with ANCA (31%) more frequently had weight loss, myalgias, arthralgias, biopsy-proven vasculitis, glomerulonephritis on biopsy, hematuria, leukocytoclastic capillaritis and/or eosinophilic infiltration of arterial wall on biopsy, and other renal disease. A total of 41% of patients had definite vasculitis manifestations (37%) or strong surrogates of vasculitis (4%), of whom only 53% had ANCA. Mononeuritis multiplex was associated with systemic vasculitis (p=0.005) and with the presence of ANCA (p<0.001). Overall, 59% of patients had polyangiitis as defined by definite vasculitis, strong surrogate of vasculitis, mononeuritis multiplex, and/or ANCA with at least one systemic manifestation other than ENT or respiratory. Patients with polyangiitis had more systemic manifestations including arthralgias (p=0.02) and renal disease (p=0.024), had higher peripheral eosinophilia (p=0.027), and a trend towards less myocarditis (p=0.057). Using predefined criteria of vasculitis and surrogates of vasculitis, ANCA alone were found to be insufficient to categorise patients with vasculitis features. We suggest a revised nomenclature and definition for EGPA and a new proposed entity referred to as hypereosinophilic asthma with systemic (non vasculitic) manifestations. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Computerized tools in psychology: cross cultural and genetically informative studies of memory

    Directory of Open Access Journals (Sweden)

    Ismatullina V.

    2016-01-01

    Full Text Available In this article we presented the computerized tools for psychological studies of memory. The importance of implementing computerized automated tools for psychological studies is discussed. It has been shown that this tools can be used both for cross-cultural and genetically informative studies. The validity of these tools for cross-cultural and genetically informative studies of memory can be seen as the first step to use automated computerized tools for big data collection in psychology.

  16. Evaluation of a computerized system for mechanical ventilation of infants.

    Science.gov (United States)

    Tehrani, Fleur T; Abbasi, Soraya

    2009-04-01

    To evaluate a computerized system for mechanical ventilation of infants. FLEX is a computerized system that includes the features of a patented mode known as adaptive-support ventilation (ASV). In addition, it has many other features including adjustment of positive end-expiratory pressure (PEEP), fraction of inspired oxygen (F(IO2)), minute ventilation, and control of weaning. It is used as an open-loop decision support system or as a closed-loop technique. Blood gas and ventilation data were collected from 12 infants in the neonatal intensive care at baseline and at the next round of evaluation. This data were input to open-loop version of FLEX. The system recommendations were compared to clinical determinations. FLEX recommended values for ventilation were on the average within 25% and 16.5% of the measured values at baseline and at the next round of evaluation, respectively. For F(IO2) and PEEP, FLEX recommended values were in general agreement with the clinical settings. FLEX recommendations for weaning were the same as the clinical determinations 50% of the time at baseline and 55% of the time at the next round of evaluation. FLEX did not recommend weaning for infants with weak spontaneous breathing effort or those who showed signs of dyspnea. A computerized system for mechanical ventilation is evaluated for treatment of infants. The results of the study show that the system has good potential for use in neonatal ventilatory care. Further refinements can be made in the system for very low-birth-weight infants.

  17. The industrial computerized tomography applied to the rock analysis

    International Nuclear Information System (INIS)

    Tetzner, Guaraciaba de Campos

    2008-01-01

    This work is a study of the possibilities of the technical applications of Computerized Tomography (CT) by using a device developed in the Radiation Technology Center (CTR), Institute for Energy and Nuclear Research (IPEN-CNEN/SP). The equipment consists of a gamma radiation source ( 60 Co), a scintillation detector of sodium iodide doped with thallium (NaI (Tl)), a mechanical system to move the object (rotation and translation) and a computer system. This operating system has been designed and developed by the CTR-IPEN-CNEN/SP team using national resources and technology. The first validation test of the equipment was carried out using a cylindrical sample of polypropylene (phantom) with two cylindrical cavities (holes) of 5 x 25 cm (diameter and length). In these tests, the holes were filled with materials of different density (air, oil and metal), whose attenuation coefficients are well known. The goal of this first test was to assess the response quality of the equipment. The present report is a study comparing computerized tomography equipment CTR-IPEN-CNEN/SP which uses a source of gamma radiation ( 60 Co) and other equipment provided by the Department of Geosciences in the University of Texas (CTUT), which uses an X-ray source (450 kV and 3.2 mA). As a result, the images obtained and the comprehensive study of the usefulness of the equipment developed here strengthened the proposition that the development of industrial computerized tomography is an important step toward consolidating the national technology. (author)

  18. CRRIS: a computerized radiological risk-investigation system

    International Nuclear Information System (INIS)

    Baes, C.F. III; Miller, C.W.

    1981-01-01

    The US Environmental Protection Agency (EPA) is responsible for regulating radioactive airborne effluents in the US. A comprehensive, integrated Computerized Radiological Risk Investigation System (CRRIS) is being developed to support EPA's radiation standards development. This modular system consists primarily of five computer codes and their supporting data bases for estimating environmental transport and radiation doses and risks. Health effects are estimated on the basis of a life-table methodology developed by EPA. CRRIS is designed to provide EPA with a reasonable and flexible way of assessing the risk to man associated with radionuclide releases to the atmosphere

  19. Castem 2000: a modern approach of computerized structural analysis

    International Nuclear Information System (INIS)

    Verpeaux, P.; Millard, A.; Hoffmann, A.; Ebersolt, L.

    1988-01-01

    Since the early beginning of the computerized structural analysis, many general purpose programs have been developed. Their complexity has increased rapidly and they became difficult to use and to maintain. The needs for an improved user's friendliness and the treatment of complex coupled problems have led to a modern tool: CASTEM 2000. It has profited by the general progress in computers technology and by a twenty years experience in large finite element codes. Its basic principles as well as examples of applications will be presented in this paper

  20. Fatal defect in computerized glow curve deconvolution of thermoluminescence

    International Nuclear Information System (INIS)

    Sakurai, T.

    2001-01-01

    The method of computerized glow curve deconvolution (CGCD) is a powerful tool in the study of thermoluminescence (TL). In a system where the plural trapping levels have the probability of retrapping, the electrons trapped at one level can transfer from this level to another through retrapping via the conduction band during reading TL. However, at present, the method of CGCD has no affect on the electron transition between the trapping levels; this is a fatal defect. It is shown by computer simulation that CGCD using general-order kinetics thus cannot yield the correct trap parameters. (author)

  1. Computerized tomography in the diagnosis of mechanical jaundice

    International Nuclear Information System (INIS)

    Grushin, Yu.V.; Manasov, T.Zh.; Raskolenko, A.A.; Nazyrova, N.K.; Dzhumashev, E.Z.

    1987-01-01

    A total of 51 patients with suspected mechanical jaundice were examined using the 3rd generation computerized tomograph. A correct conclusion as to the level and mechanism of obstruction was made in 77% of cases. The most serious problems arose in analysis of extrahepatic biliary ducts. The dilatation of the biliary passages was not always combined with their obturation. In cases which were difficult for interpretation, additional information could be obtained by using thin tomographic layers, i.v. contrast enhancement, and retrograde endoscopic cholangiography

  2. The computerized point of order processing at the dairying plant

    OpenAIRE

    Pankauskienė, Dalia

    2007-01-01

    Darbe išanalizuota IS kūrimo principai ir problemos, pieno perdirbimo įmonės veikla. Pasirinktos užsakymų priėmimo sistemos projektavimo ir projekto realizavimo priemonės. Atliktas užsakymų priėmimo IS projektavimas. Sukurta duomenų bazė, kurios pagalba suprojektuota užsakymų priėmimo kompiuterizuota darbo vieta pieno perdirbimo įmonėje. Company’s business computerization stands for creating and installing an information system which would satisfy all company’s needs. Such system’s creatio...

  3. Contribution of computerized tomography to diagnosis of primary hyperaldosteronism

    International Nuclear Information System (INIS)

    Hrabaneova, J.; Stribrna, J.; Bultasova, H.; Karasova, L.; Placer, Z.; Pinsker, P.

    1987-01-01

    Two cases are reported of computerized tomography (CT) examination for proof of suspect primary hyperaldosteronism caused by adenoma of the adrenals. The findings were then confirmed surgically and histologically. CT was again found to be an invaluable tool for differential diagnosis of this condition, which spared the patients demanding invasive examinations and clearly differentiated primary hyperaldosteronism from adrenal cortex hyperplasia. This is mainly important for the fact that adenoma or more rarely carcinoma causing primary hyperaldosteronism can surgically be removed. (L.O.). 2 figs., 2 tabs., 6 refs

  4. Core on-line monitoring and computerized procedures systems

    International Nuclear Information System (INIS)

    Gangloff, W.C.

    1986-01-01

    The availability of operating nuclear power plants has been affected significantly by the difficulty people have in coping with the complexity of the plants and the operating procedures. Two ways to use modern computer technology to ease the burden of coping are discussed in this paper, an on-line core monitoring system with predictive capability and a computerized procedures system using live plant data. These systems reduce human errors by presenting information rather than simply data, using the computer to manipulate the data, but leaving the decisions to the plant operator

  5. Computerized tomography of the mandibular joints and masticatory muscles

    International Nuclear Information System (INIS)

    Huels, A.B.

    1981-01-01

    A methodology for computerized tomography of the mandibular joints was developed and applied in 80 test persons. Imaging of the mandibular joints is possible with a tomographic technique with 5 mm-overlap, full utilisation of the enlargement capacity of the imaging device, and combined use of transversal and coronary tomography. The method yields full latero-medial, cranio-caudal and anterior-posterior views of the condyle and fossa contours, free of interferences and of distortions caused by the projection. Positional diagnoses are thus possible as well as diagnoses of pathological structural changes. (orig./MG) [de

  6. Computerized waste-accountability shipping and packaging system

    International Nuclear Information System (INIS)

    Jackson, J.A.; Baston, M. Jr.; DeVer, E.A.

    1981-01-01

    The Waste Accountability, Shipping and Packaging System (WASP) is a real-time computerized system designed and implemented by Mound Facility to meet the stringent packaging and reporting requirements of radioactive waste being shipped to burial sites. The system stores packaging data and inspection results for each unit and prepares all necessary documents at the time of shipment. Shipping data specific for each burial site are automatically prepared on magnetic tape for transmission to the computing center at that site. WASP has enabled Mound Facility to effectively meet the requirements of the burial sites, diminishing the possibility of being rejected from a site because of noncompliance

  7. Diagnostic perspectives of mobile x-ray computerized tomography

    International Nuclear Information System (INIS)

    Portnoj, L.M.; Dibirov, M.P.; Denisova, L.B.

    1992-01-01

    Mobile x-ray computerized tomography (CT) and an organization and methodological scheme of its application were assessed. CT is realized in special hospitals of large regions, where the patients with the optimal indications for CT are assembled. Over 15000 examinations were carried out with the use of the suggested CT program over 4 years, that resulted in detection of 1295 brain tumors, 804 cases with neoplastic involvement of the abdominal cavity and the retroperitoneal space. Wide application of mobile CT devices according to the program will help to decide the problem of unavailability of such examinations. One mobile device may replace 3 permanent CT devices

  8. Computerized low-level waste assay system operation manual

    International Nuclear Information System (INIS)

    Jones, D.F.; Cowder, L.R.; Martin, E.R.

    1976-01-01

    An operation and maintenance manual for the computerized low-level waste box counter is presented, which describes routine assay techniques as well as theory of operation treated in sufficient depth so that an experienced assayist can make nonroutine assays. In addition, complete system schematics are included, along with a complete circuit description to facilitate not only maintenance and troubleshooting, but also reproduction of the instrument if desired. Complete software system descriptions are included so far as calculational algorithms are concerned, although detailed instruction listings would have to be obtained from Group R-1 at LASL in order to make machine-language code changes

  9. Computerized tomography anatomy of the kidneys and retroperitoneal space

    International Nuclear Information System (INIS)

    Savchenko, A.P.; Mamaev, V.V.; Pkhakadze, Eh.G.

    1989-01-01

    The authors described the anatomy of the kidneys and retroperitoneal space in health on the basis of computerized tomography (CT) of 90 patients. Five typical levels in CT (ensuring all necessary data on roentgenomorphological trains of the kidneys and retroperitoneal space in the kidney area) were singled out. Some roentgenometric data on kidney cross-sections as well as the quantitative densitometric characterization of the parenchyma of the kidneys, renal sinus and adjacent tissues were presented. X-ray anatomy of the renal fiscia, pararenal space and perirenal fatty space of the kidney with different parts of the tetroperitoneal space was described

  10. Development and prospects of X-ray computerized tomography. I

    International Nuclear Information System (INIS)

    Dobes, V.

    1985-01-01

    The history and developmental trends are described of X-ray computerized tomography (CT) as are its applications in clinical practise. Suitable criteria and economic aspects are proposed for the choice of CT systems. The types are listed and described of X-ray CT systems, including brain, whole-body, mobile and special systems. A table is given showing available specifications (types of detectors, X-ray source, resolution, configuration, scan angles, scan fields, image reconstruction, etc.) for machines by different companies. (M.D.)

  11. Some aspects of evaluation of image quality in computerized tomography

    International Nuclear Information System (INIS)

    Travassos, Paulo Cesar Baptista; Peixoto, Jose Guilherme; Almeida, Carlos Eduardo Veloso de; Campos, Luciana Tourinho; Magalhaes, Luis Alexandre

    2016-01-01

    The evaluation of CT scanners image quality includes measuring the Hounsfield values, HU, using a table with the limit values. This table does not consider that different devices have different effective energies, which may cause some false results. The evaluation of 90 computerized tomography, by the American College Radiology methodology, showed that some failed devices in the evaluation showed excellent linear fit between the values of the linear attenuation coefficients calculated for the actual energy used, according to the HU values. The analysis of the coefficient of determination suggests that 10 of these devices could have been approved. (author)

  12. The evolution of computerized displays in accident management

    International Nuclear Information System (INIS)

    DeBor, J.

    1988-01-01

    Key regulations implemented by the NRC in 1982, which included requirements such as upgraded emergency operating procedures, detailed control room design reviews, the addition of a safety parameter display system, and the inclusion of a degreed shift technical advisor as part of the operating staff, have enabled the use of computerized displays to evolve as an integral part of accident management within each of the four main vendor groups. Problems, however, remain to be resolved in the area of technical content, information reliability, and rules for use in order to achieve the goal of more reliable accident management in nuclear power plants

  13. 2D histomorphometric quantification from 3D computerized tomography

    International Nuclear Information System (INIS)

    Lima, Inaya; Oliveira, Luis Fernando de; Lopes, Ricardo T.; Jesus, Edgar Francisco O. de; Alves, Jose Marcos

    2002-01-01

    In the present article, preliminary results are presented showing the application of the tridimensional computerized microtomographic technique (3D-μCT) to bone tissue characterization, through histomorphometric quantification which are based on stereologic concepts. Two samples of human bone were correctly prepared to be submitted to the tomographic system. The system used to realize that process were a radiographic system with a microfocus X-ray tube. Through these three processes, acquisition, reconstruction and quantification, it was possible to get the good results and coherent to the literature data. From this point, it is intended to compare these results with the information due the conventional method, that is, conventional histomorphometry. (author)

  14. COMPUTERIZED HEAT-TREATMENT IN A ZIMBABWEAN FACTORY

    Directory of Open Access Journals (Sweden)

    M. Collier

    2012-01-01

    Full Text Available In the context of Zimbabwe's current economic problems, parts of the manufacturing industry are turning their attention to the possibility of utilising local design talent in upgrading their manufacturing plants. This paper describes a project undertaken by the National University of Science and Technology to convert the heat-treatment process in a major manufacturing plant from semi -manual to a computerized one. The system comprises microcontroller connection to the furnaces and sensors, and communicates with a central computer on which software for a windowed user-interface is hosted. Experimental results for the system are presented, and a strategy for other companies in the same predicament is proposed.

  15. Computerized operator support system for the JMTR: ARGUS

    International Nuclear Information System (INIS)

    Oyamada, R.; Yamamoto, K.; Ishii, Y.; Sekine, N.; Nemoto, N.

    1988-01-01

    ARGUS is computerized operator support system developed for the JMTR Function keybords, alphanumic keybords, and colour display terminals serve as comminication interface between ARGUS and operating personnel. ARGUS serves the following purposes; 1) data logging, 2) early abnormality detection, 3) presenting relevant and concentrated information to the operators to support their accurate judgment in case of abnormality occurrence, 4) save of time-historical data for diagnostics, and 5) data base necessary for JMTR operation and maintenance. ARGUS has been implemented on a VAX-11/750 with mos memories of 7.25 MB. (author)

  16. A Candidate Gene Approach to ANCA-Associated Vasculitis Reveals Links to the C3 and CTLA-4 Genes but not to the IL1-Ra And Fcγ-RIIa Genes.

    OpenAIRE

    Persson, Ulf; Gullstrand, Birgitta; Pettersson, Åsa; Sturfelt, Gunnar; Truedsson, Lennart; Segelmark, Mårten

    2013-01-01

    Background/Aims: The aim of the study is to search for associations between Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and polymorphisms in the genes of four key molecules possibly involved in different pathogenic pathways; complement C3, CTLA-4, Fcγ-RIIa and IL1-Ra. Patients and Methods: Patients with AAV (n=105) subgrouped as microscopic polyangiitis or granulomatosis with polyangiitis (Wegener's granulomatosis) and myeloperoxidase (MPO) or proteinase 3 (PR3) A...

  17. Contribution of computerization to alarm processing: A French safety view

    Energy Technology Data Exchange (ETDEWEB)

    Cette, W [CEA Centre d` Etudes de Fontenay-aux-Roses, 92 (France). Inst. de Protection et de Surete Nucleaire

    1997-09-01

    Following the TMI accident and according to the requirement of the French safety authority, very important studies were performed by the French utility, Electricite de France (EDF), and assessed by the Institute for Nuclear Safety and Protection (IPSN) on reactor operation in conventional control rooms, particularly on alarm processing. These studies dealt with the man-machine interface, as well as design and exploitation requirements, presentation and management of alarm signals, and associated operating documents. The conclusions of these studies have led to improvements in French conventional control rooms. The current state of these control rooms and links between alarm sets and operating documents will be shortly presented in the first part of the paper. More recently, the computerized means implemented in the PWR 1400 MWe control rooms (N4) profoundly modified reactor operation. In particular, major advances concern alarm processing in comparison with conventional control rooms. The N4 plants provide a more rigorous approach in processing and presentation of alarms than in the past. Indeed, EDF wanted to have less alarms switched on during plant upsets and to make them more characteristic of a specific situation of the process. For example, computerization makes it easier to validate or inhibit alarms according to the situation, to allow the operator to manage alarm presentation and to propose on-line alarm sheets to the operator etc. This approach in comparison with conventional control rooms, and the IPSN assessment will be presented in the second part of this paper. (author).

  18. Computerized tomography of the vertebral column following traumatic lesion

    International Nuclear Information System (INIS)

    Taenzer, B.; Gmelin, E.; Burmester, E.; Babaian, E.; Weiss, H.D.; Hohlbach, G.

    1984-01-01

    In 58 patients with lesions of the vertebral column in the thoracal and lumbar section established by conventional X-ray, the informative power of computerized tomography was tested. Axial projection with the superimposition-free presentation of bone and soft-tissue structures in the motional segment clears up the diagnostically decisive question of the extent of the lesion and form of fracture, and thus provides information on the stability or instability of the fracture relevant for the therapeutic action taken. All patients had compression fractures of vertebrae, with a fragment of the front edge broken away in 50 cases and one of the back edge broken away in 17 cases. In 30 cases the intervertebral disks were damaged. 43 fractures were stable, 25 were unstable. The instability of 13 fractures was only recognized by CT. In essence, the diagnostic action to be taken begins with a grand-survey X-ray in two planes as a screening, with computerized tomography following in the positive case. Conventional tomograms are not necessary. (BWU) [de

  19. Computerized cognitive training with older adults: a systematic review.

    Directory of Open Access Journals (Sweden)

    Alexandra M Kueider

    Full Text Available A systematic review to examine the efficacy of computer-based cognitive interventions for cognitively healthy older adults was conducted. Studies were included if they met the following criteria: average sample age of at least 55 years at time of training; participants did not have Alzheimer's disease or mild cognitive impairment; and the study measured cognitive outcomes as a result of training. Theoretical articles, review articles, and book chapters that did not include original data were excluded. We identified 151 studies published between 1984 and 2011, of which 38 met inclusion criteria and were further classified into three groups by the type of computerized program used: classic cognitive training tasks, neuropsychological software, and video games. Reported pre-post training effect sizes for intervention groups ranged from 0.06 to 6.32 for classic cognitive training interventions, 0.19 to 7.14 for neuropsychological software interventions, and 0.09 to 1.70 for video game interventions. Most studies reported older adults did not need to be technologically savvy in order to successfully complete or benefit from training. Overall, findings are comparable or better than those from reviews of more traditional, paper-and-pencil cognitive training approaches suggesting that computerized training is an effective, less labor intensive alternative.

  20. A Computerized Version of the Scrambled Sentences Test

    Directory of Open Access Journals (Sweden)

    Roberto Viviani

    2018-01-01

    Full Text Available The scrambled sentences test (SST, an experimental procedure that involves participants writing down their cognitions, has been used to elicit individual differences in depressiveness and vulnerability to depression. We describe here a modification of the SST to adapt it to computerized administration, with a particular view of its use in large samples and functional neuroimaging applications. In a first study with the computerized version, we reproduce the preponderance of positive cognitions in the healthy and the inverse association of these cognitions with individual measures of depressiveness. We also report a tendency of self-referential cognitions to elicit higher positive cognition rates. In a second study, we describe the patterns of neural activations elicited by emotional and neutral sentences in a functional neuroimaging study, showing that it replicates and extends previous findings obtained with the original version of the SST. During the formation of emotional cognitions, ventral areas such as the ventral anterior cingulus and the supramarginal gyrus were relatively activated. This activation pattern speaks for the recruitment of mechanisms coordinating motivational and associative processes in the formation of value-based decisions.

  1. Assessment of Minimal HE (with emphasis on computerized psychometric tests)

    Science.gov (United States)

    Kappus, Matthew R; Bajaj, Jasmohan S

    2012-01-01

    Synopsis Minimal hepatic encephalopathy (MHE) is associated with a high risk of development of overt hepatic encephalopathy, impaired quality of life and driving accidents. The detection of MHE requires specialized testing since it cannot by definition, be diagnosed on standard clinical examination. Psychometric (paper-pencil or computerized or a combination) and neuro-physiological techniques are often used to test for MHE. Paper-pencil psychometric batteries like the Psychometric Hepatic Encephalopathy Score (PHES) have been validated in several countries but do not have US normative values. Computerized tests such as the inhibitory control test (ICT), cognitive drug research system and Scan test have proven useful to diagnose MHE and predict outcomes. The specificity and sensitivity of these tests are similar to the recommended gold standards. Neuro-physiological tests such as the EEG and its interpretations, evoked potentials and Critical Flicker Frequency (CFF) also provide useful information. The diagnosis of MHE is an important issue for clinicians and patients alike and the testing strategies depend on the normative data available, patient comfort and local expertise. PMID:22321464

  2. Findings of psychopathology and computerized tomography in neuropsychiatric diseases

    International Nuclear Information System (INIS)

    Gross, G.; Huber, G.; Schuettler, R.

    1982-01-01

    1978-1980 we examined 451 patients of the Psychiatric University Clinic of Bonn by computerized tomography. From 260 patients with characterized diseases of the brain and brain damages 78 patients had neuropsychiatric diseases of old age, i.e. cerebro-vascular processes (average age of 63.7 years) and 9 patients had primary degenerative processes of the brain (average age of 62.1 years). Patients with diseases of the cerebral vessels showed irreversible psychopathological syndromes in 87%. The rate of pathological findings in CT increases in relation to degree of severity of the chronic (irreversible) organic psychosyndromes from 76% in pseudoneurasthenics syndromes to 93% in patients with organic changes of personality and to 100% in patients with dementia. The ambiguity of the conception of the multi-infarct-dementia is discussed. Only 19% of the sample with irreversible psychopathological changes showed localized neurological deficits and infarctions in CT, but none of them more than one. In all patients with dementia a cortical atrophy was found. There is a significant positive correlation between cerebral atrophy in CT and irreversible organic psychosyndrome. These findings with computerized tomography demonstrate in accordance with earlier pneumoencephalographic findings that distinct types of irreversible psychosyndromes can be correlated to distinct types of cerebral atrophy. But these statistical correlations between the degree of the severity of the loss of psychic functions and the reduction of cerebral tissue are not necessarily valid for any single case. (orig.) [de

  3. Evaluation of the computerized procedures Manual II (COPMA II)

    International Nuclear Information System (INIS)

    Converse, S.A.

    1995-11-01

    The purpose of this study was to evaluate the effects of a computerized procedure system, the Computerized Procedure Manual II (COPMA-II), on the performance and mental workload of licensed reactor operators. To evaluate COPMA-II, eight teams of two operators were trained to operate a scaled pressurized water reactor facility (SPWRF) with traditional paper procedures and with COPMA-II. Following training, each team operated the SPWRF under normal operating conditions with both paper procedures and COPMA-II. The teams then performed one of two accident scenarios with paper procedures, but performed the remaining accident scenario with COPMA-II. Performance measures and subjective estimates of mental workload were recorded for each performance trial. The most important finding of the study was that the operators committed only half as many errors during the accident scenarios with COPMA-II as they committed with paper procedures. However, time to initiate a procedure was fastest for paper procedures for accident scenario trials. For performance under normal operating conditions, there was no difference in time to initiate or to complete a procedure, or in the number of errors committed with paper procedures and with COPMA-II. There were no consistent differences in the mental workload ratings operators recorded for trials with paper procedures and COPMA-II

  4. Computerized structural mechanics for 1990's: Advanced aircraft needs

    Science.gov (United States)

    Viswanathan, A. V.; Backman, B. F.

    1989-01-01

    The needs for computerized structural mechanics (CSM) as seen from the standpoint of the aircraft industry are discussed. These needs are projected into the 1990's with special focus on the new advanced materials. Preliminary design/analysis, research, and detail design/analysis are identified as major areas. The role of local/global analyses in these different areas is discussed. The lessons learned in the past are used as a basis for the design of a CSM framework that could modify and consolidate existing technology and include future developments in a rational and useful way. A philosophy is stated, and a set of analyses needs driven by the emerging advanced composites is enumerated. The roles of NASA, the universities, and the industry are identified. Finally, a set of rational research targets is recommended based on both the new types of computers and the increased complexity the industry faces. Computerized structural mechanics should be more than new methods in structural mechanics and numerical analyses. It should be a set of engineering applications software products that combines innovations in structural mechanics, numerical analysis, data processing, search and display features, and recent hardware advances and is organized in a framework that directly supports the design process.

  5. Ameliorating intrusive memories of distressing experiences using computerized reappraisal training.

    Science.gov (United States)

    Woud, Marcella L; Holmes, Emily A; Postma, Peggy; Dalgleish, Tim; Mackintosh, Bundy

    2012-08-01

    The types of appraisals that follow traumatic experiences have been linked to the emergence of posttraumatic stress disorder (PTSD). Could changing reappraisals following a stressful event reduce the emergence of PTSD symptoms? The present proof-of-principle study examined whether a nonexplicit, systematic computerized training in reappraisal style following a stressful event (a highly distressing film) could reduce intrusive memories of the film, and symptoms associated with posttraumatic distress over the subsequent week. Participants were trained to adopt a generally positive or negative poststressor appraisal style using a series of scripted vignettes after having been exposed to highly distressing film clips. The training targeted self-efficacy beliefs and reappraisals of secondary emotions (emotions in response to the emotional reactions elicited by the film). Successful appraisal induction was verified using novel vignettes and via change scores on the post traumatic cognitions inventory. Compared with those trained negatively, those trained positively reported in a diary fewer intrusive memories of the film during the subsequent week, and lower scores on the Impact of Event Scale (a widely used measure of posttraumatic stress symptoms). Results support the use of computerized, nonexplicit, reappraisal training after a stressful event has occurred and provide a platform for future translational studies with clinical populations that have experienced significant real-world stress or trauma.

  6. Contribution of computerization to alarm processing: A French safety view

    International Nuclear Information System (INIS)

    Cette, W.

    1997-01-01

    Following the TMI accident and according to the requirement of the French safety authority, very important studies were performed by the French utility, Electricite de France (EDF), and assessed by the Institute for Nuclear Safety and Protection (IPSN) on reactor operation in conventional control rooms, particularly on alarm processing. These studies dealt with the man-machine interface, as well as design and exploitation requirements, presentation and management of alarm signals, and associated operating documents. The conclusions of these studies have led to improvements in French conventional control rooms. The current state of these control rooms and links between alarm sets and operating documents will be shortly presented in the first part of the paper. More recently, the computerized means implemented in the PWR 1400 MWe control rooms (N4) profoundly modified reactor operation. In particular, major advances concern alarm processing in comparison with conventional control rooms. The N4 plants provide a more rigorous approach in processing and presentation of alarms than in the past. Indeed, EDF wanted to have less alarms switched on during plant upsets and to make them more characteristic of a specific situation of the process. For example, computerization makes it easier to validate or inhibit alarms according to the situation, to allow the operator to manage alarm presentation and to propose on-line alarm sheets to the operator etc. This approach in comparison with conventional control rooms, and the IPSN assessment will be presented in the second part of this paper. (author)

  7. Feasibility of computerized scheduled gradual reduction for adolescent smoking cessation.

    Science.gov (United States)

    Riley, William; Jerome, Albert; Behar, Albert; Zack, Sharon

    2002-01-01

    The purpose of this project was to modify a smoking cessation program that uses computerized scheduled gradual reduction for use with adolescent smokers and to test the feasibility of this cessation approach in group support and minimal contact modalities. Utilizing a lesson plan approach with high school marketing students in five high schools and student survey feedback, the LifeSign program was modified to be an acceptable smoking cessation program for adolescent smokers. In the first study, 17 adolescent smokers used the modified program with seven associated weekly group support sessions. At the end of treatment, 29% had quit smoking, and over half of those who continued to smoke reduced their smoking rate by 50%. In the second study, the LifeSign for Teens program was evaluated with 18 adolescent smokers in a minimal contact format. At the end of treatment, 17% had quit smoking, and mean smoking rate reductions of 43% were found among those who continued smoking. At 1-year follow-up, all subjects who had quit at posttreatment reported continuous abstinence. The results of these two small trials suggest that a computerized scheduled gradual reduction approach may be an accepted and potentially efficacious approach for smoking cessation among adolescent smokers.

  8. Development and Evaluation of a Confidence-Weighting Computerized Adaptive Testing

    Science.gov (United States)

    Yen, Yung-Chin; Ho, Rong-Guey; Chen, Li-Ju; Chou, Kun-Yi; Chen, Yan-Lin

    2010-01-01

    The purpose of this study was to examine whether the efficiency, precision, and validity of computerized adaptive testing (CAT) could be improved by assessing confidence differences in knowledge that examinees possessed. We proposed a novel polytomous CAT model called the confidence-weighting computerized adaptive testing (CWCAT), which combined a…

  9. A Case Study of Different Types of Arguments Emerging from Explorations in an Interactive Computerized Environment

    Science.gov (United States)

    Lavy, Ilana

    2006-01-01

    This paper presents a description of the different types of arguments that emerged as two students, working in a computerized environment, engaged in an investigation of several number theory concepts. The emerging arguments are seen as a result of the influence of the computerized environment together with collaborative learning. Using…

  10. 45 CFR 307.13 - Security and confidentiality for computerized support enforcement systems in operation after...

    Science.gov (United States)

    2010-10-01

    ... ENFORCEMENT SYSTEMS § 307.13 Security and confidentiality for computerized support enforcement systems in... systems in operation after October 1, 1997. (a) Information integrity and security. Have safeguards... 45 Public Welfare 2 2010-10-01 2010-10-01 false Security and confidentiality for computerized...

  11. 15 CFR 950.9 - Computerized Environmental Data and Information Retrieval Service.

    Science.gov (United States)

    2010-01-01

    ... Information Retrieval Service. 950.9 Section 950.9 Commerce and Foreign Trade Regulations Relating to Commerce... Computerized Environmental Data and Information Retrieval Service. The Environmental Data Index (ENDEX... computerized, information retrieval service provides a parallel subject-author-abstract referral service. A...

  12. INTEGRATION PECULIARITIES OF COMPUTERIZED MEANS OF EDUCATION INTO THE PROCESS OF TEACHER TRAINING AT PEDAGOGICAL COLLEGES

    Directory of Open Access Journals (Sweden)

    Olga M. Naumenko

    2010-08-01

    Full Text Available Important problems of using the computerized means of education in the process of teacher training at pedagogical college are considered. On the basis of the analysis of the organisation of educational process in different pedagogical colleges, the general principles of construction of the educational module “Methodology of computerized means of education in educational process” are considered.

  13. Density evaluation by computerized tomography in plain soils over different manipulation systems

    International Nuclear Information System (INIS)

    Pedrotti, Alceu

    1996-08-01

    The objective of this paper is the evaluation of a plain soil density in different culture systems determined by X ray computerized tomography.It was observed a larger variation in densities in soils profiles analysed. The identification of layers is better utilising computerized tomography than others technic

  14. Computerized Adaptive Test (CAT) Applications and Item Response Theory Models for Polytomous Items

    Science.gov (United States)

    Aybek, Eren Can; Demirtasli, R. Nukhet

    2017-01-01

    This article aims to provide a theoretical framework for computerized adaptive tests (CAT) and item response theory models for polytomous items. Besides that, it aims to introduce the simulation and live CAT software to the related researchers. Computerized adaptive test algorithm, assumptions of item response theory models, nominal response…

  15. Development of a Computerized In-Basket Exercise for the Classroom: A Sales Management Example

    Science.gov (United States)

    Pearson, Michael M.; Barnes, John W.; Onken, Marina H.

    2006-01-01

    This article follows the development of a sales management in-basket exercise for use in the classroom. The authors have computerized the exercise and added features to allow for additional and more quantitative input from the students. The exercise has evolved and been tested in numerous classroom situations. The computerized in-basket exercise…

  16. The Impact of Computerization on Archival Finding Aids: A RAMP Study.

    Science.gov (United States)

    Kitching, Christopher

    This report is based on a questionnaire sent to 32 selected National Archives and on interviews with archivists from eight countries. Geared to the needs of developing countries, the report covers: (1) the impact of computerization on finding aids; (2) advantages and problems of computerization, including enhanced archival control, integration of…

  17. The Effect of College Students' Self-Generated Computerized Mind Mapping on Their Reading Achievement

    Science.gov (United States)

    Sabbah, Sabah Salman

    2015-01-01

    This study explored the potential effect of college students' self-generated computerized mind maps on their reading comprehension. It also investigated the subjects' attitudes toward generating computerized mind maps for reading comprehension. The study was conducted in response to the inability of the foundation-level students, who were learning…

  18. Anti-3-[(18)F]FACBC positron emission tomography-computerized tomography and (111)In-capromab pendetide single photon emission computerized tomography-computerized tomography for recurrent prostate carcinoma: results of a prospective clinical trial.

    Science.gov (United States)

    Schuster, David M; Nieh, Peter T; Jani, Ashesh B; Amzat, Rianot; Bowman, F Dubois; Halkar, Raghuveer K; Master, Viraj A; Nye, Jonathon A; Odewole, Oluwaseun A; Osunkoya, Adeboye O; Savir-Baruch, Bital; Alaei-Taleghani, Pooneh; Goodman, Mark M

    2014-05-01

    We prospectively evaluated the amino acid analogue positron emission tomography radiotracer anti-3-[(18)F]FACBC compared to ProstaScint® ((111)In-capromab pendetide) single photon emission computerized tomography-computerized tomography to detect recurrent prostate carcinoma. A total of 93 patients met study inclusion criteria who underwent anti-3-[(18)F]FACBC positron emission tomography-computerized tomography plus (111)In-capromab pendetide single photon emission computerized tomography-computerized tomography for suspected recurrent prostate carcinoma within 90 days. Reference standards were applied by a multidisciplinary board. We calculated diagnostic performance for detecting disease. In the 91 of 93 patients with sufficient data for a consensus on the presence or absence of prostate/bed disease anti-3-[(18)F]FACBC had 90.2% sensitivity, 40.0% specificity, 73.6% accuracy, 75.3% positive predictive value and 66.7% negative predictive value compared to (111)In-capromab pendetide with 67.2%, 56.7%, 63.7%, 75.9% and 45.9%, respectively. In the 70 of 93 patients with a consensus on the presence or absence of extraprostatic disease anti-3-[(18)F]FACBC had 55.0% sensitivity, 96.7% specificity, 72.9% accuracy, 95.7% positive predictive value and 61.7% negative predictive value compared to (111)In-capromab pendetide with 10.0%, 86.7%, 42.9%, 50.0% and 41.9%, respectively. Of 77 index lesions used to prove positivity histological proof was obtained in 74 (96.1%). Anti-3-[(18)F]FACBC identified 14 more positive prostate bed recurrences (55 vs 41) and 18 more patients with extraprostatic involvement (22 vs 4). Anti-3-[(18)F]FACBC positron emission tomography-computerized tomography correctly up-staged 18 of 70 cases (25.7%) in which there was a consensus on the presence or absence of extraprostatic involvement. Better diagnostic performance was noted for anti-3-[(18)F]FACBC positron emission tomography-computerized tomography than for (111)In-capromab pendetide single

  19. 45 CFR 310.5 - What options are available for Computerized Tribal IV-D Systems and office automation?

    Science.gov (United States)

    2010-10-01

    ... IV-D Systems and office automation? 310.5 Section 310.5 Public Welfare Regulations Relating to Public... AUTOMATION Requirements for Computerized Tribal IV-D Systems and Office Automation § 310.5 What options are available for Computerized Tribal IV-D Systems and office automation? (a) Allowable computerized support...

  20. A computerized program to educate adults about environmental health risks

    International Nuclear Information System (INIS)

    Adams, M.; Dewey, J.; Schur, P.

    1993-01-01

    A computerized program called Environmental Risk Appraisal (ERA) has been developed to educate adults about environmental health risks and to motivate positive behavior change. A questionnaire addresses issues such as radon, environmental tobacco smoke, pesticides, lead, air and water pollution, and work-site risks. Responses are computer processed in seconds to produce an individualized computer printout containing a score, educational messages, and phone numbers to call for more information. A variety of audiences including environmental groups, worksites, women's organizations and health professionals were represented in this study of 269 participants. Many respondents indicated they were exposed to important environmental hazards and nearly 40 percent reported they had, or might have had, an environmental related illness at some time. Preliminary evaluation indicates the program is effective as an educational tool in raising awareness of environmental health risks

  1. Computerized classification of mass lesions in digital mammograms

    International Nuclear Information System (INIS)

    Giger, M.L.; Doi, K.; Yin, F.F.; Schmidt, R.A.; Vyborny, C.J.

    1989-01-01

    Subjective classification of masses on mammograms is a difficult task. On average, about 25% of masses referred for surgical biopsy are actually malignant. The authors are developing, as an aid to radiologists, a computerized scheme for the classification of lesions in mammograms to reduce the false-negative and false-positive diagnoses of malignancies. The classification scheme involves the extraction of border information from the mammographic lesion in order to quantify the degree of spiculation, which is related to the possibility of malignancy. Clinical film mammograms are digitized with an optical drum scanner (0.1-mm pixel size) for analysis on a Micro VAX 3500 computer. Border information (fluctuations) is obtained from the difference between the lesion border and its smoothed border. Using the rms variation of the frequency content of these fluctuations, approximately 85% of the cancerous lesions were correctly classified as malignant, while 15% of benign lesions were misclassified, in a preliminary study

  2. Cone beam computerized tomography of face. Technological assessment report

    International Nuclear Information System (INIS)

    Saint-Pierre, Francoise; Fanelli, Gaelle; Mosnegutu, Lavinia; Devaux, Frederique

    2009-12-01

    Cone beam computerized tomography is an imagery technique notably used for the maxillofacial complex or a complete or limited exploration of maxillo-mandibular and dento-alveolar structures. Typically, this technique is implemented with devices which are different from scanners in various respects (performance of several linear cuts, use of an open cone beam). Based on a literature survey, this document reports an assessment which aimed at determining technical and dosimetric performances of the device, potential benefits in terms of diagnosis and therapy with respect to existing imagery techniques, specifications and role of this technique in odonto-stomatology, maxillofacial surgery, and even in ENT, and operation conditions and training to perform this act

  3. Application of computerized procedure system for AP1000

    International Nuclear Information System (INIS)

    Wen Fang

    2012-01-01

    With the tendency of digitalisation in instrumentation and control system of nuclear power plants, AP1000, as well as other advanced PWRs, is provided with the technical basis for the application of CPS (computerized procedure system). This paper makes a brief introduction on CPS construction and function. CPS, as an advanced procedure system, does not only have the function of electronic indication for operation procedures, but also have the ability to monitor plant data, process the data and then present the status of the procedure steps to the reactor operator. In addition, advantages of CPS compared with paper-based procedures and comparison with digital operating system of one M310 plus advanced nuclear power plant are described. Moreover, based on current situation, this paper offers several suggestions on CPS localization for Sanmen AP1000 nuclear power project. Besides, the last part of this paper discusses problems we might meet during the process of CPS localization. (author)

  4. Radiation protection in computerized tomography diagnostics; Strahlenschutz in der Computertomografie

    Energy Technology Data Exchange (ETDEWEB)

    Grust, Andreas [Radiologie am Hauptbahnhof, Duesseldorf (Germany)

    2012-11-01

    The essential advantage of computerized tomography (CT) compared to projecting radiographic techniques is the display of organs free of superposition using a 3D data set and additional enhanced contrast resolution. CT is a mostly objective and examination-independent technique that has developed towards an indispensable tool for tumor diagnostics and traumatology. With respect to the total amount of X-ray diagnostic examinations CT is a rather seldom used technique, nevertheless causing a disproportionately high amount of the collective effective dose of the German population. This disadvantage triggers the necessity to work on a radiation dose reduction. The author discusses the issues X-ray tube current reduction, layer thickness, pitch factor, scan length, dose modulation, adaptive collimation, and iterative reconstruction.

  5. Computerized tomography in evaluation of decreased acetabular and femoral anteversion

    International Nuclear Information System (INIS)

    Toennis, D.; Skamel, H.J.

    2003-01-01

    Computerized tomography has received a new importance. It has been shown that decreased anteversion of femur and acetabulum, when both have decreased angles, are causing pain and osteoarthritis of the hip joint. Operative treatment should be performed before osteoarthritis develops. Exact measurements therefore are necessary. The investigation should be performed in prone position to have the pelvis lying in a defined and normal position. Femoral torsion is measured between the transverse axis of the knee and the femoral neck. The transverse axis for measurement of the femoral anteversion is defined by a rectangular line to the sagittal plane. For evaluation of the femoral anteversion in total the angle of the condyles has to be added to the femoral neck angle when the knee is found in internal rotation. Acetabular anteversion should be measured at the level where the femoral head is still in full contact and congruence with the anterior margin of the acetabulum. (orig.) [de

  6. Computerized planning and dosimetry for brachytherapy in carcinomas cervix

    International Nuclear Information System (INIS)

    Kizilbash, N.A.; Jabeen, K.; Hussain, R.

    1996-01-01

    A project on the use of computerize planning and dosimetry for brachytherapy in carcinoma of cervix was started at NORI (Nuclear Medicine, Oncology and Radiotherapy Institute, Islamabad) in september 1990. A total number of 182 patients were included in the study over a period of three years. The treatment of all these patients was done by external radiation as well as the intracavitary therapy. Planning and dosimetry was done according to ICRU 38 recommendations. 70 patients were planned with two computers TP-II (Dr. J. Cunningham's software) and PC based system (Dr. Kallinger's software, BTI system). From the results of the two computers TP-II and PC, it can be seen that the difference in a absorbed dose for all recommended points in not going to harm the patient. The dose to the bladder and the rectum in our studies is quite low because of the low activity in the ovoid sources. (author)

  7. Computerized dosimetric system for studying radiation fields of afterloading apparatus

    International Nuclear Information System (INIS)

    Andryushin, O.S.; Gorshkov, M.I.

    1988-01-01

    Works on designing a computerized dosimetric scanner (CODOS) for studying radiation fields of remote therapeutic apparatus, providing dosimetric data input from semiconductor transducers and ionization chambers directly into the computer memory were carried out. The basic problems were to provide reproducibility and accuracy of the initial dosimetric data, formation of the data bank on LUEhV-15M1 accelerator bremsstrahlung and electron radiation fields. An extra problem was to provide isodose curves for manual scheduling of radiotherapy. The 15 VUMS-28-025 complex based on Elektronika-60 computer was chosen as a host computer, photodiodes were used as a semiconductor detector, the 70108 rod chamber and VA-J-18 dosemeters were used as an ionization chamber. The results of studies with the CODOS system have been shown that it meets the dosimetric requirements for therapeutic apparatus

  8. Study on a computerized compact simulator of NHR-200

    International Nuclear Information System (INIS)

    Gao Zuying; Dong Yujie

    1997-01-01

    A fully computerized compact simulator is studied in accordance with the engineering practical need of NHR-200. A SUN SPARC 2 stand-alone workstation is selected as its computer system and multi-task structure of software is employed. Simulation program is derived from the RETRAN-02 code. The standard I/O devices are used as its interface equipment and the man-machine interface graphic program is coded on the basis of X Window System. Shared memory and semaphores are used for inter-task communication and a timer is used in real-time control of tasks. Its accuracy and simulation speed are verified by using several typical accident transients. The accuracy and speed are perfectly able to meet the requirements of engineering simulation. It is useful for normal and accident transient analysis, engineering study and design, reactor operation support and personnel training

  9. Replacement of the computerized control system at NPP under operation

    International Nuclear Information System (INIS)

    Ermolaev, A.D.; Rakitin, I.D.

    1985-01-01

    Reasons and preconditions for replacement of the computerized control systems (CCS) at NPP under operation are consi-- dered. Problems dealing with management of CCS replacement, maintenance of a new CCS as well as NPP personnel training for the new system maintenance are discussed. A necessity of NPP personnel participation in these works in order to adapt CCS to requirements of NPP operation personnel and to initiate the training process is underlined. Replacement of CCS at NPP under operation is associated, as a rule, with obsolescence of old systems not ensuring growing requirements to NPP workability and safety. Principles observed at CCS replacement are reduced, mainly, to the following; maximum utilizatian of existing equipment, metal strUctures, cables, instruments, power supplies, ventilation system minimum of construction works and new communications; the least change of acting panels and boxes; changes in control desks should be introduced on the basis of the analysis of operator actions '

  10. US Department of Energy transportation programs: computerized techniques

    International Nuclear Information System (INIS)

    Joy, D.S.; Johnson, P.E.; Fore, C.S.; Peterson, B.E.

    1984-01-01

    The US Department of Energy is currently sponsoring the development of four specialized computer-based transportation programs at Oak Ridge National Laboratory. The programs function as research tools that provide unique computerized techniques for planning the safe shipment of radioactive and hazardous materials. Major achievements include the development of interactive rail and highway routing models, an emergency response assistance program, a data base focusing on legislative requirements, and a resource file identifying key state and local contacts. A discussion of the programs and data bases is presented, and several examples reflecting each project's applications to the overall DOE transportation program are provided. The interface of these programs offers a dynamic resource of data for use during preshipment planning stages. 10 refs., 4 figs., 2 tabs

  11. Clinical study on primary epilepsy by computerized analysis of CT

    International Nuclear Information System (INIS)

    Tominaga, Hidefumi; Ueyama, Kenichi; Mizutani, Hiroshi; Imamura, Keisuke; Yoshidome, Kazushi; Matsumoto, Kei

    1985-01-01

    CT scans were examined by conventional linear measurement method and computerized analysis in 17 patients with primary epilepsy (Group A). Results were compared with those in healthy volunteers (Group B). Relationship between CT and EEG findings was also examined. The maximum width of the third cerebral ventricle (TCV) was narrowed in Group A than in Group B, with statistically significant difference. Low density rates (LDR) in Group A tended to be lower than those in Group B. There was significant difference in narrowed maximum width of TCV between Group A presenting with sudden dysrhythmia and Group B. For this type of Group A, LDR was significantly lower than that for Group B. These results suggest some changes in the brain in young epilepsy patients, especially those presenting with sudden dysrhythemia. (Namekawa, K.)

  12. Computerized detection of mass lesions in digital mammograms

    International Nuclear Information System (INIS)

    Yin, F.F.; Giger, M.L.; Doi, K.; Metz, C.E.; Vyborny, C.J.; Schmidt, R.A.

    1989-01-01

    Early detection of breast cancer from the periodic screening of asymptomatic women could reduce breast cancer mortality by at least 40%. The authors are developing a computerized scheme for the detection of mass lesions in digital mammograms as an aid to radiologists in such high volume screening programs. Based on left-right architectural symmetry and gray-level histogram analysis, bilateral subtraction of left and right breast images is performed. False-positive detections included in bilateral-difference images are reduced with various images feature-extraction techniques. The database involves clinical film mammograms digitized by a TV camera and analyzed on a Micro-VAX workstation. Among five different bilateral subtraction techniques investigated, a nonlinear approach provided superior lesion enhancement. Feature-extraction techniques reduced substantially the remaining false-positives. Preliminary results, for 32 pairs of clinical mammograms, yielded a true-positive rate of approximately 95% with a false-positive rate of about 2 per image

  13. A computerized main control room for NPP: Development and investigation

    International Nuclear Information System (INIS)

    Anokhin, A. N.; Marshall, E. C.; Rakitin, I. D.; Slonimsky, V. M.

    2006-01-01

    An ergonomics assessment of the control room at Leningrad Nuclear Power Plant has been undertaken as part of an international project funded by the EU TACIS program. The project was focused on the upgrading of the existing control facilities and the installation of a validation facility to evaluate candidate refurbishment proposals before their implementation at the plant. The ergonomics methodology applied in the investigation was wide ranging and included an analysis of reported events, extensive task analysis (including novel techniques) and validation studies using experienced operators. The paper addresses the potential difficulties for the human operator associated with fully computerized interfaces and shows how the validation facility and the outcomes from ergonomics assessment will be used to minimise any adverse impact on performance that may be caused by proposed control room changes. (authors)

  14. Computerized health physics record system at a Canadian fabrication facility

    International Nuclear Information System (INIS)

    Thind, K.S.

    1984-01-01

    This poster session will describe the types of Health Physics data input into a Hewlett-Packard 3000 computer. The Health Physics data base at this facility includes the following: employee hours data, airborne uranium concentrations, external dosemetry (badge readings), internal dosemetry (bioassay) and environmental health physics (stack sample results) data. It will describe the types of outputs achievable in the form of various reports, such as: individual employee health physics report for a given period, a general health physics summary report for a given period, individual urinalysis report, local air concentration report and graphs. The use of this computerized health physics record system in the overall radiation protection program at this facility is discussed

  15. Computerized tomography in diagnosis of parasitic hepatic lesions

    International Nuclear Information System (INIS)

    Filimonov, G.P.; Garibashvili, R.N.; Tumol'skaya, N.I.

    1984-01-01

    An attempt has been made to estimate the diagnostic importance of computerized tomography (CT) in cases of hepatic echinococcosis and alveococcosis to outline the semiotics of these lesions and to establish an order of using CT in a general diagnostic complex. 73 patients at the age of 15-70 (49 with echinococcosis, 24-alveococcosis) have been supervised. The analysis of the results of clinical CT application in cases of parasitic hepatic lesions has shown that CT permits not only to reveal parasitic nodes up to 2 cm size in the liver and other organs but give also their topographoanatomic characteristic. By means of CT one can determine interrelations of parasitic formation with vessels and hepatic bileducts, vena cava inferior, other organs. One can judge at the same time on their compression and germination, remote echinococcosis residues, other complications

  16. Sensorimotor Learning in a Computerized Athletic Training Battery.

    Science.gov (United States)

    Krasich, Kristina; Ramger, Ben; Holton, Laura; Wang, Lingling; Mitroff, Stephen R; Gregory Appelbaum, L

    2016-01-01

    Sensorimotor abilities are crucial for performance in athletic, military, and other occupational activities, and there is great interest in understanding learning in these skills. Here, behavioral performance was measured over three days as twenty-seven participants practiced multiple sessions on the Nike SPARQ Sensory Station (Nike, Inc., Beaverton, Oregon), a computerized visual and motor assessment battery. Wrist-worn actigraphy was recorded to monitor sleep-wake cycles. Significant learning was observed in tasks with high visuomotor control demands but not in tasks of visual sensitivity. Learning was primarily linear, with up to 60% improvement, but did not relate to sleep quality in this normal-sleeping population. These results demonstrate differences in the rate and capacity for learning across perceptual and motor domains, indicating potential targets for sensorimotor training interventions.

  17. Importance of computerized tomography for surgical treatment of intracranial hematomas

    International Nuclear Information System (INIS)

    Diemath, H.E.

    1982-01-01

    The improved treatment by using computerized tomography (CT) located operating theater and intensive care unit is reported in comparison of 3,382 patients with severe head injuries. By preoperative use of CT the frequency of diagnosed hermatomas was about the same (29.5% before CT; 27.0% with CT) but the preoperative diagnosed multiple hematomas were much more frequent (14.0% resp. 27.0%). The most important advantage however is the saving of time by CT in this localisation by which the chance of survival has increased from 54% to 69%. Without any doubt everywhere in neurotraumatology the CT should be situated as near as possible to the intensive care unit and to the operating theater and should be available 24 hours a day. (Author) [de

  18. Computerized asset management and maintenance systems in ST

    CERN Document Server

    Sánchez-Corral, E

    1999-01-01

    The ST division manages and therefore maintains the CERN technical installations. A maintenance database application exists for every technical domain. A total of six different databases were built during the last 10 years and are based on the RAPIER maintenance program. As the Computerized Asset Management and Maintenance Systems (CAMMS) technology has evolved, the RAPIER system has become obsolete. Therefore we are forced to migrate to its latest version, MP5, before the year 2000. The migration path must be defined, leading from the current situation to a fully operational MP5 application. The major elements of each migration path consist in determining the functionality to use, defining the operation of it, adapting and/or creating procedures, converting data and providing training. A migration is always a process of change. The migration presents a unique opportunity to evaluate the current implementations, adapt them to the requirements and exploit the new features offered. Obsolete data and inconsisten...

  19. Recovery, modernization and computerization of the monochromator MDR-23

    International Nuclear Information System (INIS)

    Miranda, L. J.

    2012-01-01

    For use in the Optics Laboratory, newly created in the CEADEN, one of the necessary equipment is the Monochromator MDR-23, which was necessary for recovery, modernization (replacing the power supply and control) and computerization by designing a VI (virtual instrument) to control stepper motor through a PC using Lab VIEW 7.1 that allows users to select the address mode, the number of steps and the engine speed and give the initial value of the position and limits the range of the monochromator to start working with it. The principle of operation of the program is done in detail to facilitate understanding of how to operate and use the graphical programming designed and achieve efficient use of equipment. (Author)

  20. Computerized provider order entry in the clinical laboratory

    Science.gov (United States)

    Baron, Jason M.; Dighe, Anand S.

    2011-01-01

    Clinicians have traditionally ordered laboratory tests using paper-based orders and requisitions. However, paper orders are becoming increasingly incompatible with the complexities, challenges, and resource constraints of our modern healthcare systems and are being replaced by electronic order entry systems. Electronic systems that allow direct provider input of diagnostic testing or medication orders into a computer system are known as Computerized Provider Order Entry (CPOE) systems. Adoption of laboratory CPOE systems may offer institutions many benefits, including reduced test turnaround time, improved test utilization, and better adherence to practice guidelines. In this review, we outline the functionality of various CPOE implementations, review the reported benefits, and discuss strategies for using CPOE to improve the test ordering process. Further, we discuss barriers to the implementation of CPOE systems that have prevented their more widespread adoption. PMID:21886891