76 FR 22399 - HIT Policy Committee's Workgroup Meetings; Notice of Meetings

Science.gov (United States)

2011-04-21

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Policy Committee's Workgroups... standards, implementation specifications, and certification criteria are needed. Date and Time: The HIT...

76 FR 28784 - HIT Policy Committee's Workgroup Meetings; Notice of Meetings

Science.gov (United States)

2011-05-18

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Policy Committee's Workgroups... standards, implementation specifications, and certification criteria are needed. Date and Time: The HIT...

77 FR 66617 - HIT Policy and Standards Committees; Workgroup Application Database

Science.gov (United States)

2012-11-06

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy and Standards Committees; Workgroup Application... of New ONC HIT FACA Workgroup Application Database. The Office of the National Coordinator (ONC) has.... Name of Committees: HIT Standards Committee and HIT Policy Committee. General Function of the...

76 FR 14974 - HIT Policy Committee's Workgroup Meetings; Notice of Meetings

Science.gov (United States)

2011-03-18

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Policy Committee's Workgroups... standards, implementation specifications, and certification criteria are needed. Date and Time: The HIT...

76 FR 50735 - HIT Policy Committee's Workgroup Meetings; Notice of Meetings

Science.gov (United States)

2011-08-16

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Policy Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Policy Committee's Workgroups... standards, implementation specifications, and certification criteria are needed. Date and Time: The HIT...

76 FR 46297 - HIT Standards Committee's Workgroup Meetings; Notice of Meetings

Science.gov (United States)

2011-08-02

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Standards Committee's... developed by the HIT Policy Committee. Date and Time: The HIT Standards Committee Workgroups will hold the...

Improving Communication Within a Managerial Workgroup

Science.gov (United States)

Harvey, Jerry B.; Boettger, C. Russell

1971-01-01

This paper describes an experiment involving the use of laboratory education (Bradford, Gibb, & Benne, 1964; Bennis & Schein, 1965) and was designed on the assumption that improvement of communication in managerial workgroups enhances task effectiveness. (Author)

Effects of organizational scheme and labeling on task performance in product-centered and user-centered retail Web sites.

Science.gov (United States)

Resnick, Marc L; Sanchez, Julian

2004-01-01

As companies increase the quantity of information they provide through their Web sites, it is critical that content is structured with an appropriate architecture. However, resource constraints often limit the ability of companies to apply all Web design principles completely. This study quantifies the effects of two major information architecture principles in a controlled study that isolates the incremental effects of organizational scheme and labeling on user performance and satisfaction. Sixty participants with a wide range of Internet and on-line shopping experience were recruited to complete a series of shopping tasks on a prototype retail shopping Web site. User-centered labels provided a significant benefit in performance and satisfaction over labels obtained through company-centered methods. User-centered organization did not result in improved performance except when the label quality was poor. Significant interactions suggest specific guidelines for allocating resources in Web site design. Applications of this research include the design of Web sites for any commercial application, particularly E-commerce.

The importance of monitoring for developing intra-group trust in Ethiopian female workgroups

NARCIS (Netherlands)

Bayissa, F.W.; Smits, J.P.J.M.; Ruben, R.

2017-01-01

We examine the relation between intra-group trust and monitoring in a patriarchal society, and how this relation affects workgroup performance. Data were collected from 352 women who were members of 72 female workgroups in Addis Ababa by means of field experiments and a survey. The data are analyzed

Response Time Analysis of Distributed Web Systems Using QPNs

Directory of Open Access Journals (Sweden)

Tomasz Rak

2015-01-01

Full Text Available A performance model is used for studying distributed Web systems. Performance evaluation is done by obtaining load test measurements. Queueing Petri Nets formalism supports modeling and performance analysis of distributed World Wide Web environments. The proposed distributed Web systems modeling and design methodology have been applied in the evaluation of several system architectures under different external loads. Furthermore, performance analysis is done to determine the system response time.

GEO Label Web Services for Dynamic and Effective Communication of Geospatial Metadata Quality

Science.gov (United States)

Lush, Victoria; Nüst, Daniel; Bastin, Lucy; Masó, Joan; Lumsden, Jo

2014-05-01

We present demonstrations of the GEO label Web services and their integration into a prototype extension of the GEOSS portal (http://scgeoviqua.sapienzaconsulting.com/web/guest/geo_home), the GMU portal (http://gis.csiss.gmu.edu/GADMFS/) and a GeoNetwork catalog application (http://uncertdata.aston.ac.uk:8080/geonetwork/srv/eng/main.home). The GEO label is designed to communicate, and facilitate interrogation of, geospatial quality information with a view to supporting efficient and effective dataset selection on the basis of quality, trustworthiness and fitness for use. The GEO label which we propose was developed and evaluated according to a user-centred design (UCD) approach in order to maximise the likelihood of user acceptance once deployed. The resulting label is dynamically generated from producer metadata in ISO or FDGC format, and incorporates user feedback on dataset usage, ratings and discovered issues, in order to supply a highly informative summary of metadata completeness and quality. The label was easily incorporated into a community portal as part of the GEO Architecture Implementation Programme (AIP-6) and has been successfully integrated into a prototype extension of the GEOSS portal, as well as the popular metadata catalog and editor, GeoNetwork. The design of the GEO label was based on 4 user studies conducted to: (1) elicit initial user requirements; (2) investigate initial user views on the concept of a GEO label and its potential role; (3) evaluate prototype label visualizations; and (4) evaluate and validate physical GEO label prototypes. The results of these studies indicated that users and producers support the concept of a label with drill-down interrogation facility, combining eight geospatial data informational aspects, namely: producer profile, producer comments, lineage information, standards compliance, quality information, user feedback, expert reviews, and citations information. These are delivered as eight facets of a wheel

Extracorporeal Treatment for Lithium Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup

Science.gov (United States)

Decker, Brian S.; Goldfarb, David S.; Dargan, Paul I.; Friesen, Marjorie; Gosselin, Sophie; Hoffman, Robert S.; Lavergne, Valéry; Nolin, Thomas D.

2015-01-01

The Extracorporeal Treatments in Poisoning Workgroup was created to provide evidence-based recommendations on the use of extracorporeal treatments in poisoning. Here, the EXTRIP workgroup presents its recommendations for lithium poisoning. After a systematic literature search, clinical and toxicokinetic data were extracted and summarized following a predetermined format. The entire workgroup voted through a two-round modified Delphi method to reach a consensus on voting statements. A RAND/UCLA Appropriateness Method was used to quantify disagreement, and anonymous votes were compiled and discussed in person. A second vote was conducted to determine the final workgroup recommendations. In total, 166 articles met inclusion criteria, which were mostly case reports, yielding a very low quality of evidence for all recommendations. A total of 418 patients were reviewed, 228 of which allowed extraction of patient-level data. The workgroup concluded that lithium is dialyzable (Level of evidence=A) and made the following recommendations: Extracorporeal treatment is recommended in severe lithium poisoning (1D). Extracorporeal treatment is recommended if kidney function is impaired and the [Li+] is >4.0 mEq/L, or in the presence of a decreased level of consciousness, seizures, or life-threatening dysrhythmias irrespective of the [Li+] (1D). Extracorporeal treatment is suggested if the [Li+] is >5.0 mEq/L, significant confusion is present, or the expected time to reduce the [Li+] to 36 hours (2D). Extracorporeal treatment should be continued until clinical improvement is apparent or [Li+] is treatments should be continued for a minimum of 6 hours if the [Li+] is not readily measurable (1D). Hemodialysis is the preferred extracorporeal treatment (1D), but continuous RRT is an acceptable alternative (1D). The workgroup supported the use of extracorporeal treatment in severe lithium poisoning. Clinical decisions on when to use extracorporeal treatment should take into account the

Extracorporeal treatment for thallium poisoning: recommendations from the EXTRIP Workgroup.

Science.gov (United States)

Ghannoum, Marc; Nolin, Thomas D; Goldfarb, David S; Roberts, Darren M; Mactier, Robert; Mowry, James B; Dargan, Paul I; Maclaren, Robert; Hoegberg, Lotte C; Laliberté, Martin; Calello, Diane; Kielstein, Jan T; Anseeuw, Kurt; Winchester, James F; Burdmann, Emmanuel A; Bunchman, Timothy E; Li, Yi; Juurlink, David N; Lavergne, Valery; Megarbane, Bruno; Gosselin, Sophie; Liu, Kathleen D; Hoffman, Robert S

2012-10-01

The EXtracorporeal TReatments In Poisoning (EXTRIP) workgroup was formed to provide recommendations on the use of extracorporeal treatment (ECTR) in poisoning. To test and validate its methods, the workgroup reviewed data for thallium (Tl). After an extensive search, the co-chairs reviewed the articles, extracted the data, summarized findings, and proposed structured voting statements following a predetermined format. A two-round modified Delphi method was chosen to reach a consensus on voting statements and RAND/UCLA Appropriateness Method to quantify disagreement. Blinded votes were compiled, returned, and discussed during a conference call. A second vote determined the final recommendations. Forty-five articles met inclusion criteria. Only case reports and case series were identified, yielding a very low quality of evidence for all recommendations. Data on 74 patients, including 11 who died, were abstracted. The workgroup concluded that Tl is slightly dialyzable and made the following recommendations: ECTR is recommended in severe Tl poisoning (1D). ECTR is indicated if Tl exposure is highly suspected on the basis of history or clinical features (2D) or if the serum Tl concentration is >1.0 mg/L (2D). ECTR should be initiated as soon as possible, ideally within 24-48 hours of Tl exposure (1D), and be continued until the serum Tl concentration is poisoning.

Collaborative labeling of malignant glioma with WebMILL: a first look

Science.gov (United States)

Singh, Eesha; Asman, Andrew J.; Xu, Zhoubing; Chambless, Lola; Thompson, Reid; Landman, Bennett A.

2012-02-01

Malignant gliomas are the most common form of primary neoplasm in the central nervous system, and one of the most rapidly fatal of all human malignancies. They are treated by maximal surgical resection followed by radiation and chemotherapy. Herein, we seek to improve the methods available to quantify the extent of tumors using newly presented, collaborative labeling techniques on magnetic resonance imaging. Traditionally, labeling medical images has entailed that expert raters operate on one image at a time, which is resource intensive and not practical for very large datasets. Using many, minimally trained raters to label images has the possibility of minimizing laboratory requirements and allowing high degrees of parallelism. A successful effort also has the possibility of reducing overall cost. This potentially transformative technology presents a new set of problems, because one must pose the labeling challenge in a manner accessible to people with little or no background in labeling medical images and raters cannot be expected to read detailed instructions. Hence, a different training method has to be employed. The training must appeal to all types of learners and have the same concepts presented in multiple ways to ensure that all the subjects understand the basics of labeling. Our overall objective is to demonstrate the feasibility of studying malignant glioma morphometry through statistical analysis of the collaborative efforts of many, minimally-trained raters. This study presents preliminary results on optimization of the WebMILL framework for neoplasm labeling and investigates the initial contributions of 78 raters labeling 98 whole-brain datasets.

Computing distance distributions from dipolar evolution data with overtones: RIDME spectroscopy with Gd(iii)-based spin labels.

Science.gov (United States)

Keller, Katharina; Mertens, Valerie; Qi, Mian; Nalepa, Anna I; Godt, Adelheid; Savitsky, Anton; Jeschke, Gunnar; Yulikov, Maxim

2017-07-21

Extraction of distance distributions between high-spin paramagnetic centers from relaxation induced dipolar modulation enhancement (RIDME) data is affected by the presence of overtones of dipolar frequencies. As previously proposed, we account for these overtones by using a modified kernel function in Tikhonov regularization analysis. This paper analyzes the performance of such an approach on a series of model compounds with the Gd(iii)-PyMTA complex serving as paramagnetic high-spin label. We describe the calibration of the overtone coefficients for the RIDME kernel, demonstrate the accuracy of distance distributions obtained with this approach, and show that for our series of Gd-rulers RIDME technique provides more accurate distance distributions than Gd(iii)-Gd(iii) double electron-electron resonance (DEER). The analysis of RIDME data including harmonic overtones can be performed using the MATLAB-based program OvertoneAnalysis, which is available as open-source software from the web page of ETH Zurich. This approach opens a perspective for the routine use of the RIDME technique with high-spin labels in structural biology and structural studies of other soft matter.

PTC MathCAD and Workgroup Manager: Implementation in a Multi-Org System

Science.gov (United States)

Jones, Corey

2015-01-01

In this presentation, the presenter will review what was done at Kennedy Space Center to deploy and implement PTC MathCAD and PTC Workgroup Manager in a multi-org system. During the presentation the presenter will explain how they configured PTC Windchill to create custom soft-types and object initialization rules for their custom numbering scheme and why they choose these methods. This presentation will also include how to modify the EPM default soft-type file in the PTC Windchill server codebase folder. The presenter will also go over the code used in a start up script to initiate PTC MathCAD and PTC Workgroup Manager in the proper order, and also set up the environment variables when running both PTC Workgroup Manager and PTC Creo. The configuration.ini file the presenter used will also be reviewed to show you how to set up the PTC Workgroup Manager and customized it to their user community. This presentation will be of interest to administrators trying to create a similar set-up in either a single org or multiple org system deployment. The big take away will be ideas and best practices learned through implementing this system, and the lessons learned what to do and not to do when setting up this configuration. Attendees will be exposed to several different sets of code used and that worked well and will hear some limitations on what the software can accomplish when configured this way.

DOORS to the semantic web and grid with a PORTAL for biomedical computing.

Science.gov (United States)

Taswell, Carl

2008-03-01

The semantic web remains in the early stages of development. It has not yet achieved the goals envisioned by its founders as a pervasive web of distributed knowledge and intelligence. Success will be attained when a dynamic synergism can be created between people and a sufficient number of infrastructure systems and tools for the semantic web in analogy with those for the original web. The domain name system (DNS), web browsers, and the benefits of publishing web pages motivated many people to register domain names and publish web sites on the original web. An analogous resource label system, semantic search applications, and the benefits of collaborative semantic networks will motivate people to register resource labels and publish resource descriptions on the semantic web. The Domain Ontology Oriented Resource System (DOORS) and Problem Oriented Registry of Tags and Labels (PORTAL) are proposed as infrastructure systems for resource metadata within a paradigm that can serve as a bridge between the original web and the semantic web. The Internet Registry Information Service (IRIS) registers [corrected] domain names while DNS publishes domain addresses with mapping of names to addresses for the original web. Analogously, PORTAL registers resource labels and tags while DOORS publishes resource locations and descriptions with mapping of labels to locations for the semantic web. BioPORT is proposed as a prototype PORTAL registry specific for the problem domain of biomedical computing.

Extracorporeal Treatment for Lithium Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup.

Science.gov (United States)

Decker, Brian S; Goldfarb, David S; Dargan, Paul I; Friesen, Marjorie; Gosselin, Sophie; Hoffman, Robert S; Lavergne, Valéry; Nolin, Thomas D; Ghannoum, Marc

2015-05-07

The Extracorporeal Treatments in Poisoning Workgroup was created to provide evidence-based recommendations on the use of extracorporeal treatments in poisoning. Here, the EXTRIP workgroup presents its recommendations for lithium poisoning. After a systematic literature search, clinical and toxicokinetic data were extracted and summarized following a predetermined format. The entire workgroup voted through a two-round modified Delphi method to reach a consensus on voting statements. A RAND/UCLA Appropriateness Method was used to quantify disagreement, and anonymous votes were compiled and discussed in person. A second vote was conducted to determine the final workgroup recommendations. In total, 166 articles met inclusion criteria, which were mostly case reports, yielding a very low quality of evidence for all recommendations. A total of 418 patients were reviewed, 228 of which allowed extraction of patient-level data. The workgroup concluded that lithium is dialyzable (Level of evidence=A) and made the following recommendations: Extracorporeal treatment is recommended in severe lithium poisoning (1D). Extracorporeal treatment is recommended if kidney function is impaired and the [Li(+)] is >4.0 mEq/L, or in the presence of a decreased level of consciousness, seizures, or life-threatening dysrhythmias irrespective of the [Li(+)] (1D). Extracorporeal treatment is suggested if the [Li(+)] is >5.0 mEq/L, significant confusion is present, or the expected time to reduce the [Li(+)] to 36 hours (2D). Extracorporeal treatment should be continued until clinical improvement is apparent or [Li(+)] is lithium poisoning. Clinical decisions on when to use extracorporeal treatment should take into account the [Li(+)], kidney function, pattern of lithium toxicity, patient's clinical status, and availability of extracorporeal treatments. Copyright © 2015 by the American Society of Nephrology.

Cultural diversity and work-group performance : Detecting the rules

NARCIS (Netherlands)

Girndt, T.

2000-01-01

With greater levels of international cooperation, work-groups are increasingly composed of members from different cultures. These groups often suffer from communication problems; however, research suggests that they also benefit from their members cultural diversity and generate higher ranges of

BrainBrowser: distributed, web-based neurological data visualization

Directory of Open Access Journals (Sweden)

Tarek eSherif

2015-01-01

Full Text Available Recent years have seen massive, distributed datasets become the norm in neuroimaging research, and the methodologies used analyze them have, in response, become more collaborative and exploratory. Tools and infrastructure are continuously being developed and deployed to facilitate research in this context: grid computation platforms to process the data, distributed data stores to house and share them, high-speed networks to move them around and collaborative, often web-based, platforms to provide access to and sometimes manage the entire system. BrainBrowser is a lightweight, high-performance JavaScript visualization library built to provide easy-to-use, powerful, on-demand visualization of remote datasets in this new research environment. BrainBrowser leverages modern Web technologies, such as WebGL, HTML5 and Web Workers, to visualize 3D surface and volumetric neuroimaging data in any modern web browser without requiring any browser plugins. It is thus trivial to integrate BrainBrowser into any web-based platform. BrainBrowser is simple enough to produce a basic web-based visualization in a few lines of code, while at the same time being robust enough to create full-featured visualization applications. BrainBrowser can dynamically load the data required for a given visualization, so no network bandwidth needs to be waisted on data that will not be used. BrainBrowser's integration into the standardized web platform also allows users to consider using 3D data visualization in novel ways, such as for data distribution, data sharing and dynamic online publications. BrainBrowser is already being used in two major online platforms, CBRAIN and LORIS, and has been used to make the 1TB MACACC dataset openly accessible.

75 FR 54163 - Office of the Secretary: Renewal of the Lake Champlain Sea Lamprey Control Alternatives Workgroup

Science.gov (United States)

2010-09-03

... (Workgroup) for 2 years. The Workgroup provides an opportunity for stakeholders to give policy and technical... Lake Champlain. FOR FURTHER INFORMATION CONTACT: Dave Tilton, Fish and Wildlife Service, Western New... copy of the Working Group's charter with the Committee Management Secretariat, General Services...

Strategic Decision-Making Learning from Label Distributions: An Approach for Facial Age Estimation.

Science.gov (United States)

Zhao, Wei; Wang, Han

2016-06-28

Nowadays, label distribution learning is among the state-of-the-art methodologies in facial age estimation. It takes the age of each facial image instance as a label distribution with a series of age labels rather than the single chronological age label that is commonly used. However, this methodology is deficient in its simple decision-making criterion: the final predicted age is only selected at the one with maximum description degree. In many cases, different age labels may have very similar description degrees. Consequently, blindly deciding the estimated age by virtue of the highest description degree would miss or neglect other valuable age labels that may contribute a lot to the final predicted age. In this paper, we propose a strategic decision-making label distribution learning algorithm (SDM-LDL) with a series of strategies specialized for different types of age label distribution. Experimental results from the most popular aging face database, FG-NET, show the superiority and validity of all the proposed strategic decision-making learning algorithms over the existing label distribution learning and other single-label learning algorithms for facial age estimation. The inner properties of SDM-LDL are further explored with more advantages.

The mediating relationship of self-awareness on supervisor burnout and workgroup Civility & Psychological Safety: A multilevel path analysis

Directory of Open Access Journals (Sweden)

William Hernandez

2015-03-01

Full Text Available The purpose of this study was to examine whether managerial self-awareness (defined as degree of agreement between self and subordinate ratings of leaders’ behaviors mediates the relationship between supervisor burnout and supervised workgroup climate. Using an HLM approach, supervisor emotional exhaustion, depersonalization and personal accomplishment exhibited significant indirect relationships with workplace Civility and Psychological Safety, via managerial self-awareness. No direct relationships between supervisor burnout and workgroup climate were found, suggesting that self-awareness may be an important mediator for individual characteristics of leaders previously thought to be non-significant. Additional post hoc comparisons indicated that workgroups with supervisors who over-rated their own performance behaviors reported the lowest levels of Civility and Psychological Safety compared to workgroups with supervisors who accurately rated or under-rated their own performance behaviors. However, supervisors that under-rated their own performance reported the highest levels of burnout, highlighting the importance of self-awareness (accurately rating oneself in relation to individual and group outcomes. The relationships between supervisor burnout, managerial self-awareness, and workgroup perceptions of Civility and Psychological Safety differed when considering the directionality of self-other rating agreement, with the negative impact of burnout at the supervisor level having a more direct impact on the workgroup level perceptions of Civility and Psychological Safety when the workgroup is managed by an under-rater, as opposed to an accurate- or over-rater. Practically, organizations should consider the role of managerial self-awareness in influencing subordinate performance and creating desirable work climates. Also, this study suggests the effects of burnout extend beyond the individual and have significant implications for the performance

Security Assessment of Web Based Distributed Applications

Directory of Open Access Journals (Sweden)

Catalin BOJA

2010-01-01

Full Text Available This paper presents an overview about the evaluation of risks and vulnerabilities in a web based distributed application by emphasizing aspects concerning the process of security assessment with regards to the audit field. In the audit process, an important activity is dedicated to the measurement of the characteristics taken into consideration for evaluation. From this point of view, the quality of the audit process depends on the quality of assessment methods and techniques. By doing a review of the fields involved in the research process, the approach wants to reflect the main concerns that address the web based distributed applications using exploratory research techniques. The results show that many are the aspects which must carefully be worked with, across a distributed system and they can be revealed by doing a depth introspective analyze upon the information flow and internal processes that are part of the system. This paper reveals the limitations of a non-existing unified security risk assessment model that could prevent such risks and vulnerabilities debated. Based on such standardize models, secure web based distributed applications can be easily audited and many vulnerabilities which can appear due to the lack of access to information can be avoided.

APFEL Web a web-based application for the graphical visualization of parton distribution functions

CERN Document Server

Carrazza, Stefano; Palazzo, Daniele; Rojo, Juan

2015-01-01

We present APFEL Web, a web-based application designed to provide a flexible user-friendly tool for the graphical visualization of parton distribution functions (PDFs). In this note we describe the technical design of the APFEL Web application, motivating the choices and the framework used for the development of this project. We document the basic usage of APFEL Web and show how it can be used to provide useful input for a variety of collider phenomenological studies. Finally we provide some examples showing the output generated by the application.

APFEL Web: a web-based application for the graphical visualization of parton distribution functions

International Nuclear Information System (INIS)

Carrazza, Stefano; Ferrara, Alfio; Palazzo, Daniele; Rojo, Juan

2015-01-01

We present APFEL Web, a Web-based application designed to provide a flexible user-friendly tool for the graphical visualization of parton distribution functions. In this note we describe the technical design of the APFEL Web application, motivating the choices and the framework used for the development of this project. We document the basic usage of APFEL Web and show how it can be used to provide useful input for a variety of collider phenomenological studies. Finally we provide some examples showing the output generated by the application. (note)

Labeling of unnatural amino acids with sup(99m)Tc and tissue distribution of the labeled products in mice

International Nuclear Information System (INIS)

Tamemasa, Osamu; Goto, Rensuke; Takeda, Atsushi

1981-01-01

The selective affinity of amino acids for pancreas, due to its high rate of protein synthesis, has prompted us to synthesize new radio-labeled amino acids for pancreatic imaging. Labeling of 19 unnatural amino acids with sup(99m)Tc was tried in the usual way, and 10 labeled products were obtained with low yields. The highest distribution of radioactivity from all these labeled amino acids, which had been injected intravenously into mice, was found in the kidney, whereas little activity was found in the pancreas. Their low distributions in stomach suggest little dissociation of the labeled amino acids into sup(99m)TcO 4 - in mice. It is presumed that these labeled amino acids behave unlike their original amino acids in the body. (author)

78 FR 22883 - AHRQ Standing Workgroup for Quality Indicator Measure Specification

Science.gov (United States)

2013-04-17

... workgroup addresses broader issues related to the measurement cycle. Because AHRQ did not get a set of... proposed updates to the AHRQ QIs. The intent is to collect feedback in a standardized fashion, and to...

Health Care System Measures to Advance Preconception Wellness: Consensus Recommendations of the Clinical Workgroup of the National Preconception Health and Health Care Initiative.

Science.gov (United States)

Frayne, Daniel J; Verbiest, Sarah; Chelmow, David; Clarke, Heather; Dunlop, Anne; Hosmer, Jennifer; Menard, M Kathryn; Moos, Merry-K; Ramos, Diana; Stuebe, Alison; Zephyrin, Laurie

2016-05-01

Preconception wellness reflects a woman's overall health before conception as a strategy to affect health outcomes for the woman, the fetus, and the infant. Preconception wellness is challenging to measure because it attempts to capture health status before a pregnancy, which may be affected by many different service points within a health care system. The Clinical Workgroup of the National Preconception Health and Health Care Initiative proposes nine core measures that can be assessed at initiation of prenatal care to index a woman's preconception wellness. A two-stage web-based modified Delphi survey and a face-to-face meeting of key opinion leaders in women's reproductive health resulted in identifying seven criteria used to determine the core measures. The Workgroup reached unanimous agreement on an aggregate of nine preconception wellness measures to serve as a surrogate but feasible assessment of quality preconception care within the larger health community. These include indicators for: 1) pregnancy intention, 2) access to care, 3) preconception multivitamin with folic acid use, 4) tobacco avoidance, 5) absence of uncontrolled depression, 6) healthy weight, 7) absence of sexually transmitted infections, 8) optimal glycemic control in women with pregestational diabetes, and 9) teratogenic medication avoidance. The focus of the proposed measures is to quantify the effect of health care systems on advancing preconception wellness. The Workgroup recommends that health care systems adopt these nine preconception wellness measures as a metric to monitor performance of preconception care practice. Over time, monitoring these baseline measures will establish benchmarks and allow for comparison within and among regions, health care systems, and communities to drive improvements.

Diversity climate enhances work outcomes through trust and openness in workgroup communication.

Science.gov (United States)

Hofhuis, Joep; van der Rijt, Pernill G A; Vlug, Martijn

2016-01-01

Diversity climate, defined as an organizational climate characterized by openness towards and appreciation of individual differences, has been shown to enhance outcomes in culturally diverse teams. To date, it remains unclear which processes are responsible for these findings. This paper presents two quantitative studies (n = 91; 246) that identify trust and openness in workgroup communication as possible mediators. We replicate earlier findings that perceived diversity climate positively relates to job satisfaction, sense of inclusion, work group identification and knowledge sharing in teams. In study 1, trust is shown to mediate the effects of perceived diversity climate on team members' sense of inclusion. In study 2, trust mediates the relationship between perceived diversity climate and workgroup identification and openness mediates its relationship with knowledge sharing.

Synthesis and distribution of L-glutamic acid with three different labels

International Nuclear Information System (INIS)

Cohen, M.B.; Spolter, Leonard; Chia Chin Chang; MacDonald, N.S.

1982-01-01

A study was performed to compare the distribution of C-11 L-glutamic acid, labeled on the carboxyl group of either the alpha or gamma carbon with that of N-13 L-glutamic acid in order to determine if the position of the label is of importance in the study of the distribution of glutamic acid

Web services for distributed and interoperable hydro-information systems

Science.gov (United States)

Horak, J.; Orlik, A.; Stromsky, J.

2008-03-01

Web services support the integration and interoperability of Web-based applications and enable machine-to-machine interaction. The concepts of web services and open distributed architecture were applied to the development of T-DSS, the prototype customised for web based hydro-information systems. T-DSS provides mapping services, database related services and access to remote components, with special emphasis placed on the output flexibility (e.g. multilingualism), where SOAP web services are mainly used for communication. The remote components are represented above all by remote data and mapping services (e.g. meteorological predictions), modelling and analytical systems (currently HEC-HMS, MODFLOW and additional utilities), which support decision making in water management.

Model driven design of distribution patterns for web service compositions

OpenAIRE

2006-01-01

Increasingly, distributed systems are being constructed by composing a number of discrete components. This practice, termed composition, is particularly prevalent within the Web service domain. Here, enterprise systems are built from many existing discrete applications, often legacy applications exposed using Web service interfaces. There are a number of architectural configurations or distribution patterns, which express how a composed system is to be deployed. However, the amount o...

78 FR 5810 - AHRQ Standing Workgroup for Quality Indicator Measure Specification

Science.gov (United States)

2013-01-28

... collaboratively publish peer-reviewed journal articles or reports based on workgroup activities. However, this is..., quality alliances, medical or specialty societies, measure developers, accrediting organizations, and... topics include: (1) Strategic areas for AHRQ QI program development for the upcoming year, (2) measure...

76 FR 39107 - HIT Standards Committee's Workgroup Meetings; Notice of Meetings

Science.gov (United States)

2011-07-05

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee's Workgroup Meetings; Notice of Meetings AGENCY: Office of the National Coordinator for Health Information Technology, HHS. ACTION: Notice... of the Office of the National Coordinator for Health Information Technology (ONC). The [[Page 39108...

Group versus individual risk choices in female workgroups in Ethiopia

NARCIS (Netherlands)

Bayissa, F.W.; Smits, J.P.J.M.; Ruben, R.

2017-01-01

A lottery choice task was conducted to examine the risk attitudes of 352 Ethiopian women who were members of 72 female workgroups in the spices processing business in Addis Ababa. The women were asked to make risk choices on their own, and the same choices together with the other members of their

Fatty acid biomarkers: validation of food web and trophic markers using C-13-labelled fatty acids in juvenile sandeel ( Ammodytes tobianus )

DEFF Research Database (Denmark)

Dalsgaard, Anne Johanne Tang; St. John, Michael

2004-01-01

A key issue in marine science is parameterizing trophic interactions in marine food webs, thereby developing an understanding of the importance of top-down and bottom-up controls on populations of key trophic players. This study validates the utility of fatty acid food web and trophic markers usi......), respectively. Lack of temporal trends in nonlabelled fatty acids confirmed the conservative incorporation of labelled fatty acids by the fish.......A key issue in marine science is parameterizing trophic interactions in marine food webs, thereby developing an understanding of the importance of top-down and bottom-up controls on populations of key trophic players. This study validates the utility of fatty acid food web and trophic markers using...... C-13-labelled fatty acids to verify the conservative incorporation of fatty acid tracers by juvenile sandeel (Ammodytes tobianus) and assess their uptake, clearance, and metabolic turnover rates. Juvenile sandeel were fed for 16 days in the laboratory on a formulated diet enriched in (13)C16...

OntoTrader: An Ontological Web Trading Agent Approach for Environmental Information Retrieval

Directory of Open Access Journals (Sweden)

Luis Iribarne

2014-01-01

Full Text Available Modern Web-based Information Systems (WIS are becoming increasingly necessary to provide support for users who are in different places with different types of information, by facilitating their access to the information, decision making, workgroups, and so forth. Design of these systems requires the use of standardized methods and techniques that enable a common vocabulary to be defined to represent the underlying knowledge. Thus, mediation elements such as traders enrich the interoperability of web components in open distributed systems. These traders must operate with other third-party traders and/or agents in the system, which must also use a common vocabulary for communication between them. This paper presents the OntoTrader architecture, an Ontological Web Trading agent based on the OMG ODP trading standard. It also presents the ontology needed by some system agents to communicate with the trading agent and the behavioral framework for the SOLERES OntoTrader agent, an Environmental Management Information System (EMIS. This framework implements a “Query-Searching/Recovering-Response” information retrieval model using a trading service, SPARQL notation, and the JADE platform. The paper also presents reflection, delegation and, federation mediation models and describes formalization, an experimental testing environment in three scenarios, and a tool which allows our proposal to be evaluated and validated.

75 FR 52309 - Pacific Fishery Management Council; Tule Chinook Workgroup Meeting

Science.gov (United States)

2010-08-25

... management approach for Columbia River natural tule chinook . This meeting of the TCW is open to the public... approach as a formal conservation objective in the Salmon FMP. Although nonemergency issues not contained... Fishery Management Council; Tule Chinook Workgroup Meeting AGENCY: National Marine Fisheries Service (NMFS...

76 FR 28784 - HIT Standards Committee's Workgroup Meetings; Notice of Meetings

Science.gov (United States)

2011-05-18

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Standards Committee's... implementation of the Federal Health IT Strategic Plan, and in accordance with policies developed by the HIT...

76 FR 50736 - HIT Standards Committee's Workgroup Meetings; Notice of Meetings

Science.gov (United States)

2011-08-16

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Standards Committee's... implementation of the Federal Health IT Strategic Plan, and in accordance with policies developed by the HIT...

76 FR 14975 - HIT Standards Committee's Workgroup Meetings; Notice of Meetings

Science.gov (United States)

2011-03-18

... DEPARTMENT OF HEALTH AND HUMAN SERVICES HIT Standards Committee's Workgroup Meetings; Notice of... be open to the public via dial-in access only. Name of Committees: HIT Standards Committee's... implementation of the Federal Health IT Strategic Plan, and in accordance with policies developed by the HIT...

The Role of the Decision-Making Regime on Cooperation in a Workgroup Social Dilemma: An Examination of Cyberloafing

Directory of Open Access Journals (Sweden)

Brice Corgnet

2015-11-01

Full Text Available A burgeoning problem facing organizations is the loss of workgroup productivity due to cyberloafing. The current paper examines how changes in the decision-making rights about what workgroup members can do on the job affect cyberloafing and subsequent work productivity. We compare two different types of decision-making regimes: autocratic decision-making and group voting. Using a laboratory experiment to simulate a data-entry organization, we find that, while autocratic decision-making and group voting regimes both curtail cyberloafing (by over 50%, it is only in group voting that there is a substantive improvement (of 38% in a cyberloafer’s subsequent work performance. Unlike autocratic decision-making, group voting leads to workgroups outperforming the control condition where cyberloafing could not be stopped. Additionally, only in the group voting regime did production levels of cyberloafers and non-loafers converge over time.

Extracorporeal treatment for theophylline poisoning: systematic review and recommendations from the EXTRIP workgroup.

Science.gov (United States)

Ghannoum, Marc; Wiegand, Timothy J; Liu, Kathleen D; Calello, Diane P; Godin, Melanie; Lavergne, Valery; Gosselin, Sophie; Nolin, Thomas D; Hoffman, Robert S

2015-05-01

The Extracorporeal Treatments in Poisoning workgroup was created to provide evidence-based recommendations on the use of extracorporeal treatments (ECTRs) in poisoning. Here, the workgroup presents its systematic review and recommendations for theophylline. After a systematic review of the literature, a subgroup reviewed articles, extracted data, summarized findings, and proposed structured voting statements following a pre-determined format. A two-round modified Delphi method was chosen to reach a consensus on voting statements and the RAND/UCLA Appropriateness Method was used to quantify disagreement. Anonymous votes were compiled, returned, and discussed. A second vote determined the final recommendations. 141 articles were included: 6 in vitro studies, 4 animal studies, 101 case reports/case series, 7 descriptive cohorts, 4 observational studies, and 19 pharmacokinetic studies, yielding a low-to-very-low quality of evidence for all recommendations. Data on 143 patients were reviewed, including 10 deaths. The workgroup concluded that theophylline is dialyzable (level of evidence = A) and made the following recommendations: ECTR is recommended in severe theophylline poisoning (1C). Specific recommendations for ECTR include a theophylline concentration [theophylline] > 100 mg/L (555 μmol/L) in acute exposure (1C), the presence of seizures (1D), life-threatening dysrhythmias (1D) or shock (1D), a rising [theophylline] despite optimal therapy (1D), and clinical deterioration despite optimal care (1D). In chronic poisoning, ECTR is suggested if [theophylline] > 60 mg/L (333 μmol/L) (2D) or if the [theophylline] > 50 mg/L (278 μmol/L) and the patient is either less than 6 months of age or older than 60 years of age (2D). ECTR is also suggested if gastrointestinal decontamination cannot be administered (2D). ECTR should be continued until clinical improvement is apparent or the [theophylline] is poisoning is amenable to ECTRs. The workgroup recommended

Extracorporeal treatment for carbamazepine poisoning: Systematic review and recommendations from the EXTRIP workgroup

Science.gov (United States)

Ghannoum, Marc; Yates, Christopher; Galvao, Tais F.; Sowinski, Kevin M.; Vo, Thi Hai Vân; Coogan, Andrew; Gosselin, Sophie; Lavergne, Valery; Nolin, Thomas D.; Hoffman, Robert S.

2014-01-01

Abstract Context. The Extracorporeal Treatments in Poisoning (EXTRIP) workgroup was created to provide evidence and consensus-based recommendations on the use of extracorporeal treatments (ECTRs) in poisoning. Objectives. To perform a systematic review and provide clinical recommendations for ECTR in carbamazepine poisoning. Methods. After a systematic literature search, the subgroup extracted the data and summarized the findings following a pre-determined format. The entire workgroup voted via a two-round modified Delphi method to reach a consensus on voting statements, using a RAND/UCLA Appropriateness Method to quantify disagreement. Anonymous votes were compiled, returned, and discussed in person. A second vote determined the final recommendations. Results. Seventy-four articles met inclusion criteria. Articles included case reports, case series, descriptive cohorts, pharmacokinetic studies, and in-vitro studies; two poor-quality observational studies were identified, yielding a very low quality of evidence for all recommendations. Data on 173 patients, including 6 fatalities, were reviewed. The workgroup concluded that carbamazepine is moderately dialyzable and made the following recommendations: ECTR is suggested in severe carbamazepine poisoning (2D). ECTR is recommended if multiple seizures occur and are refractory to treatment (1D), or if life-threatening dysrhythmias occur (1D). ECTR is suggested if prolonged coma or respiratory depression requiring mechanical ventilation are present (2D) or if significant toxicity persists, particularly when carbamazepine concentrations rise or remain elevated, despite using multiple-dose activated charcoal (MDAC) and supportive measures (2D). ECTR should be continued until clinical improvement is apparent (1D) or the serum carbamazepine concentration is below 10 mg/L (42 the μ in μmol/L looks weird.) (2D). Intermittent hemodialysis is the preferred ECTR (1D), but both intermittent hemoperfusion (1D) or continuous

Adapting Web content for low-literacy readers by using lexical elaboration and named entities labeling

Science.gov (United States)

Watanabe, W. M.; Candido, A.; Amâncio, M. A.; De Oliveira, M.; Pardo, T. A. S.; Fortes, R. P. M.; Aluísio, S. M.

2010-12-01

This paper presents an approach for assisting low-literacy readers in accessing Web online information. The "Educational FACILITA" tool is a Web content adaptation tool that provides innovative features and follows more intuitive interaction models regarding accessibility concerns. Especially, we propose an interaction model and a Web application that explore the natural language processing tasks of lexical elaboration and named entity labeling for improving Web accessibility. We report on the results obtained from a pilot study on usability analysis carried out with low-literacy users. The preliminary results show that "Educational FACILITA" improves the comprehension of text elements, although the assistance mechanisms might also confuse users when word sense ambiguity is introduced, by gathering, for a complex word, a list of synonyms with multiple meanings. This fact evokes a future solution in which the correct sense for a complex word in a sentence is identified, solving this pervasive characteristic of natural languages. The pilot study also identified that experienced computer users find the tool to be more useful than novice computer users do.

Label Distribution in Tissues of Wheat Seedlings Cultivated with Tritium-Labeled Leonardite Humic Acid

Science.gov (United States)

Kulikova, Natalia A.; Abroskin, Dmitry P.; Badun, Gennady A.; Chernysheva, Maria G.; Korobkov, Viktor I.; Beer, Anton S.; Tsvetkova, Eugenia A.; Senik, Svetlana V.; Klein, Olga I.; Perminova, Irina V.

2016-06-01

Humic substances (HS) play important roles in the biotic-abiotic interactions of the root plant and soil contributing to plant adaptation to external environments. However, their mode of action on plants remains largely unknown. In this study the HS distribution in tissues of wheat seedlings was examined using tritium-labeled humic acid (HA) derived from leonardite (a variety of lignites) and microautoradiography (MAR). Preferential accumulation of labeled products from tritiated HA was found in the roots as compared to the shoots, and endodermis was shown to be the major control point for radial transport of label into vascular system of plant. Tritium was also found in the stele and xylem tissues indicating that labeled products from tritiated HA could be transported to shoot tissues via the transpiration stream. Treatment with HA lead to an increase in the content of polar lipids of photosynthetic membranes. The observed accumulation of labeled HA products in root endodermis and positive impact on lipid synthesis are consistent with prior reported observations on physiological effects of HS on plants such as enhanced growth and development of lateral roots and improvement/repairs of the photosynthetic status of plants under stress conditions.

Label Distribution in Tissues of Wheat Seedlings Cultivated with Tritium-Labeled Leonardite Humic Acid

Science.gov (United States)

Kulikova, Natalia A.; Abroskin, Dmitry P.; Badun, Gennady A.; Chernysheva, Maria G.; Korobkov, Viktor I.; Beer, Anton S.; Tsvetkova, Eugenia A.; Senik, Svetlana V.; Klein, Olga I.; Perminova, Irina V.

2016-01-01

Humic substances (HS) play important roles in the biotic-abiotic interactions of the root plant and soil contributing to plant adaptation to external environments. However, their mode of action on plants remains largely unknown. In this study the HS distribution in tissues of wheat seedlings was examined using tritium-labeled humic acid (HA) derived from leonardite (a variety of lignites) and microautoradiography (MAR). Preferential accumulation of labeled products from tritiated HA was found in the roots as compared to the shoots, and endodermis was shown to be the major control point for radial transport of label into vascular system of plant. Tritium was also found in the stele and xylem tissues indicating that labeled products from tritiated HA could be transported to shoot tissues via the transpiration stream. Treatment with HA lead to an increase in the content of polar lipids of photosynthetic membranes. The observed accumulation of labeled HA products in root endodermis and positive impact on lipid synthesis are consistent with prior reported observations on physiological effects of HS on plants such as enhanced growth and development of lateral roots and improvement/repairs of the photosynthetic status of plants under stress conditions. PMID:27350412

Capataz: a framework for distributing algorithms via the World Wide Web

Directory of Open Access Journals (Sweden)

Gonzalo J. Martínez

2015-08-01

Full Text Available In recent years, some scientists have embraced the distributed computing paradigm. As experiments and simulations demand ever more computing power, coordinating the efforts of many different processors is often the only reasonable resort. We developed an open-source distributed computing framework based on web technologies, and named it Capataz. Acting as an HTTP server, web browsers running on many different devices can connect to it to contribute in the execution of distributed algorithms written in Javascript. Capataz takes advantage of architectures with many cores using web workers. This paper presents an improvement in Capataz´ usability and why it was needed. In previous experiments the total time of distributed algorithms proved to be susceptible to changes in the execution time of the jobs. The system now adapts by bundling jobs together if they are too simple. The computational experiment to test the solution is a brute force estimation of pi. The benchmark results show that by bundling jobs, the overall perfomance is greatly increased.

Web-Based Distributed Simulation of Aeronautical Propulsion System

Science.gov (United States)

Zheng, Desheng; Follen, Gregory J.; Pavlik, William R.; Kim, Chan M.; Liu, Xianyou; Blaser, Tammy M.; Lopez, Isaac

2001-01-01

An application was developed to allow users to run and view the Numerical Propulsion System Simulation (NPSS) engine simulations from web browsers. Simulations were performed on multiple INFORMATION POWER GRID (IPG) test beds. The Common Object Request Broker Architecture (CORBA) was used for brokering data exchange among machines and IPG/Globus for job scheduling and remote process invocation. Web server scripting was performed by JavaServer Pages (JSP). This application has proven to be an effective and efficient way to couple heterogeneous distributed components.

Web Based Distributed Coastal Image Analysis System, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — This project develops Web based distributed image analysis system processing the Moderate Resolution Imaging Spectroradiometer (MODIS) data to provide decision...

Rucio WebUI - The Web Interface for the ATLAS Distributed Data Management

CERN Document Server

Beermann, Thomas; The ATLAS collaboration; Barisits, Martin-Stefan; Serfon, Cedric; Garonne, Vincent

2016-01-01

With the current distributed data management system for ATLAS, called Rucio, all user interactions, e.g. the Rucio command line tools or the ATLAS workload management system, communicate with Rucio through the same REST-API. This common interface makes it possible to interact with Rucio using a lot of different programming languages, including Javascript. Using common web application frameworks like JQuery and web.py, a web application for Rucio was built. The main component is R2D2 - the Rucio Rule Definition Droid - which gives the users a simple way to manage their data on the grid. They can search for particular datasets and get details about its metadata and available replicas and easily create rules to create new replicas and delete them if not needed anymore. On the other hand it is possible for site admins to restrict transfers to their site by setting quotas and manually approve transfers. Besides R2D2 additional features include transfer backlog monitoring for shifters, group space monitoring for gr...

The validity of a web-based FFQ assessed by doubly labelled water and multiple 24-h recalls.

Science.gov (United States)

Medin, Anine C; Carlsen, Monica H; Hambly, Catherine; Speakman, John R; Strohmaier, Susanne; Andersen, Lene F

2017-12-01

The aim of this study was to validate the estimated habitual dietary intake from a newly developed web-based FFQ (WebFFQ), for use in an adult population in Norway. In total, ninety-two individuals were recruited. Total energy expenditure (TEE) measured by doubly labelled water was used as the reference method for energy intake (EI) in a subsample of twenty-nine women, and multiple 24-h recalls (24HR) were used as the reference method for the relative validation of macronutrients and food groups in the entire sample. Absolute differences, ratios, crude and deattenuated correlations, cross-classifications, Bland-Altman plot and plots between misreporting of EI (EI-TEE) and the relative misreporting of food groups (WebFFQ-24HR) were used to assess the validity. Results showed that EI on group level was not significantly different from TEE measured by doubly labelled water (0·7 MJ/d), but ranking abilities were poor (r -0·18). The relative validation showed an overestimation for the majority of the variables using absolute intakes, especially for the food groups 'vegetables' and 'fish and shellfish', but an improved agreement between the test and reference tool was observed for energy adjusted intakes. Deattenuated correlation coefficients were between 0·22 and 0·89, and low levels of grossly misclassified individuals (0-3 %) were observed for the majority of the energy adjusted variables for macronutrients and food groups. In conclusion, energy estimates from the WebFFQ should be used with caution, but the estimated absolute intakes on group level and ranking abilities seem acceptable for macronutrients and most food groups.

The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

NARCIS (Netherlands)

McKhann, G.M.; Knopman, D.S.; Chertkow, H.; Hyman, B.T.; Jack, C.R.; Kawas, C.H.; Klunk, W.E.; Koroshetz, W.J.; Manly, J.J.; Mayeux, R.; Mohs, R.C.; Morris, J.C.; Rossor, M.N.; Scheltens, P.; Carrillo, M.C.; Thies, B.; Weintraub, S.; Phelps, C.H.

2011-01-01

The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of revising the 1984 criteria for Alzheimer's disease (AD) dementia. The workgroup sought to ensure that the revised criteria would be flexible enough to be used by both general healthcare providers

Flowing together : a longitudinal study of collective efficacy and collective flow among workgroups.

NARCIS (Netherlands)

Salanova, Marisa; Rodríguez-Sánchez, Alma M.; Schaufeli, Wilmar B.; Cifre, Eva

2014-01-01

The aim of this study is to extend the Channel Model of Flow (Csikszentmihalyi, 1975, 1990) at the collective level (workgroups) by including collective efficacy beliefs as a predictor of collective flow based on the Social Cognitive Theory (Bandura, 1997, 2001). A two-wave longitudinal lab study

Distribution of /sup 51/Cr labelled endotoxin on tissue and intracellular organella in mice

Energy Technology Data Exchange (ETDEWEB)

Saito, K; Suzuki, M; Okuaki, A; Saito, M [Fukushima Medical Coll. (Japan)

1976-10-01

The distribution of /sup 51/Cr labelled endotoxin was investigated in mice. The degree of toxicity between non-labelled endotoxin and /sup 51/Cr labelled endotoxin did not change. /sup 51/Cr-endotoxin was distributed in the highest levels in the liver, and to a lesser degree in the intestine, lungs, spleen and kidneys. The affinity of the tissue to /sup 51/Cr-endotoxin was strongest in the liver followed by the spleen, lungs, kidneys and intestine. /sup 51/Cr-endotoxin was distributed mainly in the mitochondrial fraction and the nuclear fraction in the intracellular species. /sup 51/Cr-endotoxin was distributed only in the liver and the intestine when a small dose was administered. It was also distributed in the lungs, spleen and kidneys when a large dose was given, but the uptake in the liver was somewhat limited. /sup 51/Cr-endotoxin was distributed mainly in the liver and the spleen in the mice that survived one week.

The 1996 meeting of the national technical workgroup on mixed waste thermal treatment

International Nuclear Information System (INIS)

1996-01-01

The National Technical Workgroup on Mixed Waste Thermal Treatment held its annual meeting in Atlanta Georgia on March 12-14, 1996. The National Technical Workgroup (NTW) and this meeting were sponsored under an interagency agreement between EPA and DOE. The 1996 Annual Meeting was hosted by US DOE Oak Ridge Operations in conjunction with Lockheed Martin Energy Systems - Center for Waste Management. A new feature of the annual meeting was the Permit Writer Panel Session which provided an opportunity for the state and federal permit writers to discuss issues and potential solutions to permitting mixed waste treatment systems. In addition, there was substantial discussion on the impacts of the Waste Combustion Performance Standards on mixed waste thermal treatment which are expected to proposed very soon. The 1996 meeting also focussed on two draft technical resource documents produced by NTW on Waste Analysis Plans and Compliance Test Procedures. Issues discussed included public involvement, waste characterization, and emission issues

Arcade: A Web-Java Based Framework for Distributed Computing

Science.gov (United States)

Chen, Zhikai; Maly, Kurt; Mehrotra, Piyush; Zubair, Mohammad; Bushnell, Dennis M. (Technical Monitor)

2000-01-01

Distributed heterogeneous environments are being increasingly used to execute a variety of large size simulations and computational problems. We are developing Arcade, a web-based environment to design, execute, monitor, and control distributed applications. These targeted applications consist of independent heterogeneous modules which can be executed on a distributed heterogeneous environment. In this paper we describe the overall design of the system and discuss the prototype implementation of the core functionalities required to support such a framework.

DATA EXTRACTION AND LABEL ASSIGNMENT FOR WEB DATABASES

OpenAIRE

T. Rajesh; T. Prathap; S.Naveen Nambi; A.R. Arunachalam

2015-01-01

Deep Web contents are accessed by queries submitted to Web databases and the returned data records are en wrapped in dynamically generated Web pages (they will be called deep Web pages in this paper). The structured data that Extracting from deep Web pages is a challenging problem due to the underlying intricate structures of such pages. Until now, a too many number of techniques have been proposed to address this problem, but all of them have limitations because they are Web-page-programming...

Reliable file sharing in distributed operating system using web RTC

Science.gov (United States)

Dukiya, Rajesh

2017-12-01

Since, the evolution of distributed operating system, distributed file system is come out to be important part in operating system. P2P is a reliable way in Distributed Operating System for file sharing. It was introduced in 1999, later it became a high research interest topic. Peer to Peer network is a type of network, where peers share network workload and other load related tasks. A P2P network can be a period of time connection, where a bunch of computers connected by a USB (Universal Serial Bus) port to transfer or enable disk sharing i.e. file sharing. Currently P2P requires special network that should be designed in P2P way. Nowadays, there is a big influence of browsers in our life. In this project we are going to study of file sharing mechanism in distributed operating system in web browsers, where we will try to find performance bottlenecks which our research will going to be an improvement in file sharing by performance and scalability in distributed file systems. Additionally, we will discuss the scope of Web Torrent file sharing and free-riding in peer to peer networks.

Young worker safety in construction: do family ties and workgroup size affect hazard exposures and safety practices?

Science.gov (United States)

Rauscher, Kimberly J; Myers, Douglas J; Runyan, Carol W; Schulman, Michael

2012-01-01

Little is known about how social aspects of the work environment influence exposures or safety practices affecting young construction workers. Our objective was to investigate whether working on a construction site with a small number of workers (≤10 vs. 11-50) or having a family-firm connection (working in a family-owned firm or one in which a family member also works) impacts hazard exposures and safety practices. Participants included 187 North Carolina construction workers 14 to 17 years old who were surveyed about their jobs. We conducted stratified analyses using cross-tabulations and chi-square statistics to measure associations between workgroup size (i.e., the total number of workers on a jobsite) and family-firm connections (yes/no) and hazard exposures (e.g., saws) and safety practices (e.g., supervision). Having a family-firm connection was associated with fewer hazard exposures and greater safety practices. Youth who worked on jobsites with a larger workgroup (11-50 workers) reported more hazards but also more safety practices. Family-firm connections, in particular, may have a protective effect for youth in construction. Even though the statistical significance of our findings on workgroup size was limited in places, the pattern of differences found suggest that further research in this area is warranted.

Computer-Aided Systems Engineering for Flight Research Projects Using a Workgroup Database

Science.gov (United States)

Mizukami, Masahi

2004-01-01

An online systems engineering tool for flight research projects has been developed through the use of a workgroup database. Capabilities are implemented for typical flight research systems engineering needs in document library, configuration control, hazard analysis, hardware database, requirements management, action item tracking, project team information, and technical performance metrics. Repetitive tasks are automated to reduce workload and errors. Current data and documents are instantly available online and can be worked on collaboratively. Existing forms and conventional processes are used, rather than inventing or changing processes to fit the tool. An integrated tool set offers advantages by automatically cross-referencing data, minimizing redundant data entry, and reducing the number of programs that must be learned. With a simplified approach, significant improvements are attained over existing capabilities for minimal cost. By using a workgroup-level database platform, personnel most directly involved in the project can develop, modify, and maintain the system, thereby saving time and money. As a pilot project, the system has been used to support an in-house flight experiment. Options are proposed for developing and deploying this type of tool on a more extensive basis.

A Web-based Distributed Voluntary Computing Platform for Large Scale Hydrological Computations

Science.gov (United States)

Demir, I.; Agliamzanov, R.

2014-12-01

Distributed volunteer computing can enable researchers and scientist to form large parallel computing environments to utilize the computing power of the millions of computers on the Internet, and use them towards running large scale environmental simulations and models to serve the common good of local communities and the world. Recent developments in web technologies and standards allow client-side scripting languages to run at speeds close to native application, and utilize the power of Graphics Processing Units (GPU). Using a client-side scripting language like JavaScript, we have developed an open distributed computing framework that makes it easy for researchers to write their own hydrologic models, and run them on volunteer computers. Users will easily enable their websites for visitors to volunteer sharing their computer resources to contribute running advanced hydrological models and simulations. Using a web-based system allows users to start volunteering their computational resources within seconds without installing any software. The framework distributes the model simulation to thousands of nodes in small spatial and computational sizes. A relational database system is utilized for managing data connections and queue management for the distributed computing nodes. In this paper, we present a web-based distributed volunteer computing platform to enable large scale hydrological simulations and model runs in an open and integrated environment.

Multi-Paradigm and Multi-Lingual Information Extraction as Support for Medical Web Labelling Authorities

Directory of Open Access Journals (Sweden)

Martin Labsky

2010-10-01

Full Text Available Until recently, quality labelling of medical web content has been a pre-dominantly manual activity. However, the advances in automated text processing opened the way to computerised support of this activity. The core enabling technology is information extraction (IE. However, the heterogeneity of websites offering medical content imposes particular requirements on the IE techniques to be applied. In the paper we discuss these requirements and describe a multi-paradigm approach to IE addressing them. Experiments on multi-lingual data are reported. The research has been carried out within the EU MedIEQ project.

ESIM_DSN Web-Enabled Distributed Simulation Network

Science.gov (United States)

Bedrossian, Nazareth; Novotny, John

2002-01-01

In this paper, the eSim(sup DSN) approach to achieve distributed simulation capability using the Internet is presented. With this approach a complete simulation can be assembled from component subsystems that run on different computers. The subsystems interact with each other via the Internet The distributed simulation uses a hub-and-spoke type network topology. It provides the ability to dynamically link simulation subsystem models to different computers as well as the ability to assign a particular model to each computer. A proof-of-concept demonstrator is also presented. The eSim(sup DSN) demonstrator can be accessed at http://www.jsc.draper.com/esim which hosts various examples of Web enabled simulations.

MARVIN: Distributed reasoning over large-scale Semantic Web data

NARCIS (Netherlands)

Oren, E.; Kotoulas, S.; Anadiotis, G.; Siebes, R.M.; ten Teije, A.C.M.; van Harmelen, F.A.H.

2009-01-01

Many Semantic Web problems are difficult to solve through common divide-and-conquer strategies, since they are hard to partition. We present Marvin, a parallel and distributed platform for processing large amounts of RDF data, on a network of loosely coupled peers. We present our divide-conquer-swap

Effects of different discount levels on healthy products coupled with a healthy choice label, special offer label or both: results from a web-based supermarket experiment.

Science.gov (United States)

Waterlander, Wilma E; Steenhuis, Ingrid H M; de Boer, Michiel R; Schuit, Albertine J; Seidell, Jacob C

2013-05-16

Two strategies commonly recommended to improve population diets include food labels and food taxes/subsidies. The aim of this study was to examine the effects of both strategies separately and in combination. An experiment with a 3x3 factorial design was conducted, including: three levels of price reduction (10%; 25%; and 50%) x three labels ('special offer', 'healthy choice' and 'special offer & healthy choice') on healthy foods defined following the Choices front-of-pack nutrition label. N=109 participants completed the experiment by conducting a typical weekly shop for their household at a three-dimensional web-based supermarket. Data were analysed using analysis of covariance. Participants receiving a 50% price discount purchased significantly more healthy foods for their household in a typical weekly shop than the 10% discount (+8.7 items; 95%CI=3.8-13.6) and the 25% discount group (+7.7 items; 95%CI=2.74 - 12.6). However, the proportion of healthy foods was not significantly higher and the discounts lead to an increased amount of energy purchased. No significant effects of the labels were found. This study brings some relevant insights into the effects of price discounts on healthier foods coupled with different labels and shows that price effects over shadowed food labels. However, price discounts seem to have ambiguous effects; they do encourage the purchase of healthy products, but also lead to increased energy purchases. More research is needed to examine how pricing strategies can work in directing consumers towards interchanging unhealthier options for healthier alternatives.

Distributing Congestion Management System Information Using the World Wide Web

Science.gov (United States)

1997-01-01

The Internet is a unique medium for the distribution of information, and it provides a tremendous opportunity to take advantage of peoples innate interest in transportation issues as they relate to their own lives. In particular, the World Wide Web (...

Effects of different discount levels on healthy products coupled with a healthy choice label, special offer label or both: results from a web-based supermarket experiment

Science.gov (United States)

2013-01-01

Background Two strategies commonly recommended to improve population diets include food labels and food taxes/subsidies. The aim of this study was to examine the effects of both strategies separately and in combination. Findings An experiment with a 3x3 factorial design was conducted, including: three levels of price reduction (10%; 25%; and 50%) x three labels (‘special offer’, ‘healthy choice’ and ‘special offer & healthy choice’) on healthy foods defined following the Choices front-of-pack nutrition label. N = 109 participants completed the experiment by conducting a typical weekly shop for their household at a three-dimensional web-based supermarket. Data were analysed using analysis of covariance. Participants receiving a 50% price discount purchased significantly more healthy foods for their household in a typical weekly shop than the 10% discount (+8.7 items; 95%CI = 3.8-13.6) and the 25% discount group (+7.7 items; 95%CI = 2.74 – 12.6). However, the proportion of healthy foods was not significantly higher and the discounts lead to an increased amount of energy purchased. No significant effects of the labels were found. Conclusion This study brings some relevant insights into the effects of price discounts on healthier foods coupled with different labels and shows that price effects over shadowed food labels. However, price discounts seem to have ambiguous effects; they do encourage the purchase of healthy products, but also lead to increased energy purchases. More research is needed to examine how pricing strategies can work in directing consumers towards interchanging unhealthier options for healthier alternatives. PMID:23680347

Private Labels

OpenAIRE

Kolmačková, Zuzana

2013-01-01

This Bachelor Thesis titled Private labels deals with distribution strategy based on the introduction of private labels especially in retail chains. At the beginning it is focused on the general concept of private label offered by retailers, where is mentioned basic characteristics, history and structuring of distribution brands. Subsequently this thesis informs readers about the introduction of new special distribution brands, which focus primarily on the new consumption habits of customers....

International Review of Standards and Labeling Programs for Distribution Transformers

Energy Technology Data Exchange (ETDEWEB)

Letschert, Virginie [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Scholand, Michael [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Carreño, Ana María [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hernandez, Carolina [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

2017-06-20

Transmission and distribution (T&D) losses in electricity networks represent 8.5% of final energy consumption in the world. In Latin America, T&D losses range between 6% and 20% of final energy consumption, and represent 7% in Chile. Because approximately one-third of T&D losses take place in distribution transformers alone, there is significant potential to save energy and reduce costs and carbon emissions through policy intervention to increase distribution transformer efficiency. A large number of economies around the world have recognized the significant impact of addressing distribution losses and have implemented policies to support market transformation towards more efficient distribution transformers. As a result, there is considerable international experience to be shared and leveraged to inform countries interested in reducing distribution losses through policy intervention. The report builds upon past international studies of standards and labeling (S&L) programs for distribution transformers to present the current energy efficiency programs for distribution transformers around the world.

Modelo de programación asíncrona para Web transaccionales en un ambiente distribuido Asynchronous programming model for transactional Web in a distributed environment

Directory of Open Access Journals (Sweden)

Luis Marco Cáceres Alvarez

2011-06-01

Full Text Available El presente trabajo define y detalla un modelo de programación asíncrono para sistemas de información Web transaccionales orientado a servicios en un ambiente distribuido uniendo las ventajas de las técnicas de programación Web asíncronas (AJAX, patrones de diseño orientados a objetos y servicios Web, para la obtención de aplicativos caracterizados por ser tolerantes a fallos, distribuidos, eficientes y usables. Principalmente se puntualizan los problemas encontrados en el modelo para uso de servicios Web clásicos, por ende se define, documenta y desarrolla un modelo de programación que solucione y mejore los servicios Web clásicos y se valide la solución a través del desarrollo de un prototipo basado en el modelo de programación definido.The present work defines and details an asynchronous programming model for transactional web information systems in distributed environment, joining the advantages of web asynchronous programming techniques (AJAX, object oriented design patterns and web services, to obtain fail tolerant, distributed, efficient and usable applications. The problems found in the classical Web services model are pointed out and a new model to solve and improve most common web services is defined, documented and developed. Also, a prototype is developed to validate the given solution using the defined model.

Implementation of Web-based Information Systems in Distributed Organizations

DEFF Research Database (Denmark)

Bødker, Keld; Pors, Jens Kaaber; Simonsen, Jesper

2004-01-01

This article presents results elicited from studies conducted in relation to implementing a web-based information system throughout a large distributed organization. We demonstrate the kind of expectations and conditions for change that management face in relation to open-ended, configurable......, and context specific web-based information systems like Lotus QuickPlace. Our synthesis from the empirical findings is related to two recent models, the improvisational change management model suggested by Orlikowski and Hofman (1997), and Gallivan's (2001) model for organizational adoption and assimilation....... In line with comparable approaches from the knowledge management area (Dixon 2000; Markus 2001), we relate to, refine, and operationalize the models from an overall organizational view by identifying and characterizing four different and general implementation contexts...

Web party effect: a cocktail party effect in the web environment

OpenAIRE

Sara Rigutti; Carlo Fantoni; Walter Gerbino

2015-01-01

In goal-directed web navigation, labels compete for selection: this process often involves knowledge integration and requires selective attention to manage the dizziness of web layouts. Here we ask whether the competition for selection depends on all web navigation options or only on those options that are more likely to be useful for information seeking, and provide evidence in favor of the latter alternative. Participants in our experiment navigated a representative set of real websites of ...

Extracorporeal treatment for barbiturate poisoning: recommendations from the EXTRIP Workgroup.

Science.gov (United States)

Mactier, Robert; Laliberté, Martin; Mardini, Joelle; Ghannoum, Marc; Lavergne, Valery; Gosselin, Sophie; Hoffman, Robert S; Nolin, Thomas D

2014-09-01

The EXTRIP (Extracorporeal Treatments in Poisoning) Workgroup conducted a systematic review of barbiturate poisoning using a standardized evidence-based process to provide recommendations on the use of extracorporeal treatment (ECTR) in patients with barbiturate poisoning. The authors reviewed all articles, extracted data, summarized key findings, and proposed structured voting statements following a predetermined format. A 2-round modified Delphi method was used to reach a consensus on voting statements, and the RAND/UCLA Appropriateness Method was used to quantify disagreement. 617 articles met the search inclusion criteria. Data for 538 patients were abstracted and evaluated. Only case reports, case series, and nonrandomized observational studies were identified, yielding a low quality of evidence for all recommendations. Using established criteria, the workgroup deemed that long-acting barbiturates are dialyzable and short-acting barbiturates are moderately dialyzable. Four key recommendations were made. (1) The use of ECTR should be restricted to cases of severe long-acting barbiturate poisoning. (2) The indications for ECTR in this setting are the presence of prolonged coma, respiratory depression necessitating mechanical ventilation, shock, persistent toxicity, or increasing or persistently elevated serum barbiturate concentrations despite treatment with multiple-dose activated charcoal. (3) Intermittent hemodialysis is the preferred mode of ECTR, and multiple-dose activated charcoal treatment should be continued during ECTR. (4) Cessation of ECTR is indicated when clinical improvement is apparent. This report provides detailed descriptions of the rationale for all recommendations. In summary, patients with long-acting barbiturate poisoning should be treated with ECTR provided at least one of the specific criteria in the first recommendation is present. Copyright © 2014 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

A Web-Based Institutional DICOM Distribution System with the Integration of the Clinical Trial Processor (CTP)

NARCIS (Netherlands)

Aryanto, K. Y. E.; Broekema, A; Langenhuysen, R. G. A.; Oudkerk, M.; van Ooijen, P. M. A.

To develop and test a fast and easy rule-based web-environment with optional de-identification of imaging data to facilitate data distribution within a hospital environment. A web interface was built using Hypertext Preprocessor (PHP), an open source scripting language for web development, and Java

Web-based Distributed Medical Information System for Chronic Viral Hepatitis

Science.gov (United States)

Yang, Ying; Qin, Tuan-fa; Jiang, Jian-ning; Lu, Hui; Ma, Zong-e.; Meng, Hong-chang

2008-11-01

To make a long-term dynamic monitoring to the chronically ill, especially patients of HBV A, we build a distributed Medical Information System for Chronic Viral Hepatitis (MISCHV). The Web-based system architecture and its function are described, and the extensive application and important role are also presented.

Web-based surveillance and global Salmonella distribution, 2000-2002

DEFF Research Database (Denmark)

Galanis, E.; Wong, Danilo Lo Fo; Patrick, M.E.

2006-01-01

Salmonellae are a common cause of foodborne disease worldwide. The World Health Organization (WHO) supports international foodborne disease surveillance through WHO Global Salm-Surv and other activities. WHO Global Salm-Surv members annually report the 15 most frequently isolated Salmonella...... serotypes to a Web-based country databank. We describe the global distribution of reported Salmonella serotypes from human and nonhuman sources from 2000 to 2002. Among human isolates, Salmonella enterica serovar Enteritidis was the most common serotype, accounting for 65% of all isolates. Among nonhuman...... professionals to explore hypotheses related to the sources and distribution of salmonellae worldwide....

The Osseus platform: a prototype for advanced web-based distributed simulation

Science.gov (United States)

Franceschini, Derrick; Riecken, Mark

2016-05-01

Recent technological advances in web-based distributed computing and database technology have made possible a deeper and more transparent integration of some modeling and simulation applications. Despite these advances towards true integration of capabilities, disparate systems, architectures, and protocols will remain in the inventory for some time to come. These disparities present interoperability challenges for distributed modeling and simulation whether the application is training, experimentation, or analysis. Traditional approaches call for building gateways to bridge between disparate protocols and retaining interoperability specialists. Challenges in reconciling data models also persist. These challenges and their traditional mitigation approaches directly contribute to higher costs, schedule delays, and frustration for the end users. Osseus is a prototype software platform originally funded as a research project by the Defense Modeling & Simulation Coordination Office (DMSCO) to examine interoperability alternatives using modern, web-based technology and taking inspiration from the commercial sector. Osseus provides tools and services for nonexpert users to connect simulations, targeting the time and skillset needed to successfully connect disparate systems. The Osseus platform presents a web services interface to allow simulation applications to exchange data using modern techniques efficiently over Local or Wide Area Networks. Further, it provides Service Oriented Architecture capabilities such that finer granularity components such as individual models can contribute to simulation with minimal effort.

Web Services Implementations at Land Process and Goddard Earth Sciences Distributed Active Archive Centers

Science.gov (United States)

Cole, M.; Bambacus, M.; Lynnes, C.; Sauer, B.; Falke, S.; Yang, W.

2007-12-01

NASA's vast array of scientific data within its Distributed Active Archive Centers (DAACs) is especially valuable to both traditional research scientists as well as the emerging market of Earth Science Information Partners. For example, the air quality science and management communities are increasingly using satellite derived observations in their analyses and decision making. The Air Quality Cluster in the Federation of Earth Science Information Partners (ESIP) uses web infrastructures of interoperability, or Service Oriented Architecture (SOA), to extend data exploration, use, and analysis and provides a user environment for DAAC products. In an effort to continually offer these NASA data to the broadest research community audience, and reusing emerging technologies, both NASA's Goddard Earth Science (GES) and Land Process (LP) DAACs have engaged in a web services pilot project. Through these projects both GES and LP have exposed data through the Open Geospatial Consortiums (OGC) Web Services standards. Reusing several different existing applications and implementation techniques, GES and LP successfully exposed a variety data, through distributed systems to be ingested into multiple end-user systems. The results of this project will enable researchers world wide to access some of NASA's GES & LP DAAC data through OGC protocols. This functionality encourages inter-disciplinary research while increasing data use through advanced technologies. This paper will concentrate on the implementation and use of OGC Web Services, specifically Web Map and Web Coverage Services (WMS, WCS) at GES and LP DAACs, and the value of these services within scientific applications, including integration with the DataFed air quality web infrastructure and in the development of data analysis web applications.

Web based parallel/distributed medical data mining using software agents

Energy Technology Data Exchange (ETDEWEB)

Kargupta, H.; Stafford, B.; Hamzaoglu, I.

1997-12-31

This paper describes an experimental parallel/distributed data mining system PADMA (PArallel Data Mining Agents) that uses software agents for local data accessing and analysis and a web based interface for interactive data visualization. It also presents the results of applying PADMA for detecting patterns in unstructured texts of postmortem reports and laboratory test data for Hepatitis C patients.

System configuration on Web with mashup.

OpenAIRE

清水, 宏泰; SHIMIZU, Hiroyasu

2014-01-01

Mashup become trend for create Web service due to popularizing cloud service. Mashup is method for create Web service from several Web services and API. Mashup has a few problems. One of the problem is deference of data format and label. Semantic Web can solve it. This paper propose method of building a system on Web with mashup using semantic Web. Mashup system configuration can express as URL. So, editing URL for mashup is editing system configuration. And any device can use this system on ...

Impact of electronic-alerting of acute kidney injury: workgroup statements from the 15(th) ADQI Consensus Conference.

Science.gov (United States)

Hoste, Eric A J; Kashani, Kianoush; Gibney, Noel; Wilson, F Perry; Ronco, Claudio; Goldstein, Stuart L; Kellum, John A; Bagshaw, Sean M

2016-01-01

Among hospitalized patients, acute kidney injury is common and associated with significant morbidity and risk for mortality. The use of electronic health records (EHR) for prediction and detection of this important clinical syndrome has grown in the past decade. The steering committee of the 15(th) Acute Dialysis Quality Initiative (ADQI) conference dedicated a workgroup with the task of identifying elements that may impact the course of events following Acute Kidney Injury (AKI) e-alert. Following an extensive, non-systematic literature search, we used a modified Delphi process to reach consensus regarding several aspects of the utilization of AKI e-alerts. Topics discussed in this workgroup included progress in evidence base practices, the characteristics of an optimal e-alert, the measures of efficacy and effectiveness, and finally what responses would be considered best practices following AKI e-alerts. Authors concluded that the current evidence for e-alert system efficacy, although growing, remains insufficient. Technology and human-related factors were found to be crucial elements of any future investigation or implementation of such tools. The group also concluded that implementation of such systems should not be done without a vigorous plan to evaluate the efficacy and effectiveness of e-alerts. Efficacy and effectiveness of e-alerts should be measured by context-specific process and patient outcomes. Finally, the group made several suggestions regarding the clinical decision support that should be considered following successful e-alert implementation. This paper reflects the findings of a non-systematic review and expert opinion. We recommend implementation of the findings of this workgroup report for use of AKI e-alerts.

How to Read a Nutrition Facts Label

Medline Plus

Full Text Available ... label. These labels have a lot of important information — on fat and calories, serving sizes, sodium content, ... Nondiscrimination Visit the Nemours Web site. Note: All information on KidsHealth® is for educational purposes only. For ...

Drug distribution in man: a positron emission tomography study after oral administration of the labelled neuroprotective drug vinpocetine

International Nuclear Information System (INIS)

Gulyas, Balazs; Halldin, Christer; Sandell, Johan; Farde, Lars; Sovago, Judit; Cselenyi, Zsolt; Vas, Adam; Kiss, Bela; Karpati, Egon

2002-01-01

Direct information on the distribution of a drug requires measurements in various tissues. Such data have until now been obtained in animals, or have indirectly been calculated from plasma measurements in humans using mathematical models. Here we suggest the use of positron emission tomography (PET) as a method to obtain direct measurements of drug distribution in the human body. The distribution in body and brain of vinpocetine, a neuroprotective drug widely used in the prevention and treatment of cerebrovascular diseases, was followed after oral administration. Vinpocetine was labelled with carbon-11 and radioactivity was measured by PET in stomach, liver, brain and kidney in six healthy volunteers. The radioactivity in blood and urine as well as the fractions of [ 11 C]vinpocetine and labelled metabolites in plasma were also determined. After oral administration, [ 11 C]vinpocetine appeared immediately in the stomach and within minutes in the liver and the blood. In the blood the level of radioactivity continuously increased until the end of the measurement period, whereas the fraction of the unchanged mother compound decreased. Radioactivity uptake and distribution in the brain were demonstrable from the tenth minute after the administration of the labelled drug. Brain distribution was heterogeneous, similar to the distribution previously reported after intravenous administration. These findings indicate that vinpocetine, administered orally in humans, readily enters the bloodstream from the stomach and gastrointestinal tract and, consequently, passes the blood-brain barrier and enters the brain. Radioactivity from [ 11 C]vinpocetine was also demonstrated in the kidneys and in urine, indicating that at least a part of the radioactive drug and labelled metabolites is eliminated from the body through the kidneys. This study is the first to demonstrate that PET might be a useful, direct and non-invasive tool to study the distribution and pharmacokinetics of orally

Drug distribution in man: a positron emission tomography study after oral administration of the labelled neuroprotective drug vinpocetine.

Science.gov (United States)

Gulyás, Balázs; Halldin, Christer; Sóvágó, Judit; Sandell, Johan; Cselényi, Zsolt; Vas, Adám; Kiss, Béla; Kárpáti, Egon; Farde, Lars

2002-08-01

Direct information on the distribution of a drug requires measurements in various tissues. Such data have until now been obtained in animals, or have indirectly been calculated from plasma measurements in humans using mathematical models. Here we suggest the use of positron emission tomography (PET) as a method to obtain direct measurements of drug distribution in the human body. The distribution in body and brain of vinpocetine, a neuroprotective drug widely used in the prevention and treatment of cerebrovascular diseases, was followed after oral administration. Vinpocetine was labelled with carbon-11 and radioactivity was measured by PET in stomach, liver, brain and kidney in six healthy volunteers. The radioactivity in blood and urine as well as the fractions of [(11)C]vinpocetine and labelled metabolites in plasma were also determined. After oral administration, [(11)C]vinpocetine appeared immediately in the stomach and within minutes in the liver and the blood. In the blood the level of radioactivity continuously increased until the end of the measurement period, whereas the fraction of the unchanged mother compound decreased. Radioactivity uptake and distribution in the brain were demonstrable from the tenth minute after the administration of the labelled drug. Brain distribution was heterogeneous, similar to the distribution previously reported after intravenous administration. These findings indicate that vinpocetine, administered orally in humans, readily enters the bloodstream from the stomach and gastrointestinal tract and, consequently, passes the blood-brain barrier and enters the brain. Radioactivity from [(11)C]vinpocetine was also demonstrated in the kidneys and in urine, indicating that at least a part of the radioactive drug and labelled metabolites is eliminated from the body through the kidneys. This study is the first to demonstrate that PET might be a useful, direct and non-invasive tool to study the distribution and pharmacokinetics of orally

Distributed Management of Concurrent Web Service Transactions

DEFF Research Database (Denmark)

Alrifai, Mohammad; Dolog, Peter; Balke, Wolf-Tilo

2009-01-01

Business processes involve dynamic compositions of interleaved tasks. Therefore, ensuring reliable transactional processing of Web services is crucial for the success of Web service-based B2B and B2C applications. But the inherent autonomy and heterogeneity of Web services render the applicability...... of conventional ACID transaction models for Web services far from being straightforward. Current Web service transaction models relax the isolation property and rely on compensation mechanisms to ensure atomicity of business transactions in the presence of service failures. However, ensuring consistency...... in the open and dynamic environment of Web services, where interleaving business transactions enter and exit the system independently, remains an open issue. In this paper, we address this problem and propose an architecture that supports concurrency control on the Web services level. An extension...

Applying Semantic Web technologies to improve the retrieval, credibility and use of health-related web resources.

Science.gov (United States)

Mayer, Miguel A; Karampiperis, Pythagoras; Kukurikos, Antonis; Karkaletsis, Vangelis; Stamatakis, Kostas; Villarroel, Dagmar; Leis, Angela

2011-06-01

The number of health-related websites is increasing day-by-day; however, their quality is variable and difficult to assess. Various "trust marks" and filtering portals have been created in order to assist consumers in retrieving quality medical information. Consumers are using search engines as the main tool to get health information; however, the major problem is that the meaning of the web content is not machine-readable in the sense that computers cannot understand words and sentences as humans can. In addition, trust marks are invisible to search engines, thus limiting their usefulness in practice. During the last five years there have been different attempts to use Semantic Web tools to label health-related web resources to help internet users identify trustworthy resources. This paper discusses how Semantic Web technologies can be applied in practice to generate machine-readable labels and display their content, as well as to empower end-users by providing them with the infrastructure for expressing and sharing their opinions on the quality of health-related web resources.

Distribution of nitrogen-13 from labeled nitrate (13NO3-) in humans and rats

International Nuclear Information System (INIS)

Witter, J.P.; Gatley, S.J.; Balish, E.

1979-01-01

The body distribution of gavaged or intravenously administered nitrate labeled with nitrogen-13 was studied in humans and rats with the following results: (1) the labeled compound is not quickly absorbed from the stomach; (2) the concentration of the label increases inside the lower intestinal tract (cecum and large intestine) when ingested or intravenously injected; and (3) humans and rats have the capacity to store a portion of the label in their bodies. These observations indicate that depletion of body stores, the passage of nitrate down the gut, or the secretion of nitrate into the intestinal lumen may be a better explanation of the urinary, ileal, and fecal concentrations of nitrate and nitrate recently measured in humans than a bacterial nitrification reaction in the intestines, as suggested by Tannenbaum, et al

Identification and management of distributed data NGN, content-centric networks and the web

CERN Document Server

Bartolomeo, Giovanni

2013-01-01

Although several books and academic courses discuss data management and networking, few of them focus on the convergence of networking and software technologies for identifying, addressing, and managing distributed data. Focusing on this convergence, Identification and Management of Distributed Data: NGN, Content-Centric Networks and the Web collates and describes the various distributed data management technologies to help readers from various backgrounds understand the common aspects that govern distributed data management. With a focus on the primary problems in identifying, addressing, and

Extracorporeal treatment for valproic acid poisoning: systematic review and recommendations from the EXTRIP workgroup.

Science.gov (United States)

Ghannoum, Marc; Laliberté, Martin; Nolin, Thomas D; MacTier, Robert; Lavergne, Valery; Hoffman, Robert S; Gosselin, Sophie

2015-06-01

The EXtracorporeal TReatments In Poisoning (EXTRIP) workgroup presents its systematic review and clinical recommendations on the use of extracorporeal treatment (ECTR) in valproic acid (VPA) poisoning. The lead authors reviewed all of the articles from a systematic literature search, extracted the data, summarized the key findings, and proposed structured voting statements following a predetermined format. A two-round modified Delphi method was chosen to reach a consensus on voting statements and the RAND/UCLA Appropriateness Method was used to quantify disagreement. Anonymous votes were compiled, returned, and discussed in person. A second vote was conducted to determine the final workgroup recommendations. The latest literature search conducted in November 2014 retrieved a total of 79 articles for final qualitative analysis, including one observational study, one uncontrolled cohort study with aggregate analysis, 70 case reports and case series, and 7 pharmacokinetic studies, yielding a very low quality of evidence for all recommendations. Clinical data were reported for 82 overdose patients while pharmaco/toxicokinetic grading was performed in 55 patients. The workgroup concluded that VPA is moderately dialyzable (level of evidence = B) and made the following recommendations: ECTR is recommended in severe VPA poisoning (1D); recommendations for ECTR include a VPA concentration > 1300 mg/L (9000 μmol/L)(1D), the presence of cerebral edema (1D) or shock (1D); suggestions for ECTR include a VPA concentration > 900 mg/L (6250 μmol/L)(2D), coma or respiratory depression requiring mechanical ventilation (2D), acute hyperammonemia (2D), or pH ≤ 7.10 (2D). Cessation of ECTR is indicated when clinical improvement is apparent (1D) or the serum VPA concentration is between 50 and 100 mg/L (350-700 μmol/L)(2D). Intermittent hemodialysis is the preferred ECTR in VPA poisoning (1D). If hemodialysis is not available, then intermittent hemoperfusion (1D) or continuous

Worldwide telemedicine services based on distributed multimedia electronic patient records by using the second generation Web server hyperwave.

Science.gov (United States)

Quade, G; Novotny, J; Burde, B; May, F; Beck, L E; Goldschmidt, A

1999-01-01

A distributed multimedia electronic patient record (EPR) is a central component of a medicine-telematics application that supports physicians working in rural areas of South America, and offers medical services to scientists in Antarctica. A Hyperwave server is used to maintain the patient record. As opposed to common web servers--and as a second generation web server--Hyperwave provides the capability of holding documents in a distributed web space without the problem of broken links. This enables physicians to browse through a patient's record by using a standard browser even if the patient's record is distributed over several servers. The patient record is basically implemented on the "Good European Health Record" (GEHR) architecture.

Extracorporeal Treatment in Phenytoin Poisoning: Systematic Review and Recommendations from the EXTRIP (Extracorporeal Treatments in Poisoning) Workgroup.

Science.gov (United States)

Anseeuw, Kurt; Mowry, James B; Burdmann, Emmanuel A; Ghannoum, Marc; Hoffman, Robert S; Gosselin, Sophie; Lavergne, Valery; Nolin, Thomas D

2016-02-01

The Extracorporeal Treatments in Poisoning (EXTRIP) Workgroup conducted a systematic literature review using a standardized process to develop evidence-based recommendations on the use of extracorporeal treatment (ECTR) in patients with phenytoin poisoning. The authors reviewed all articles, extracted data, summarized findings, and proposed structured voting statements following a predetermined format. A 2-round modified Delphi method was used to reach a consensus on voting statements, and the RAND/UCLA Appropriateness Method was used to quantify disagreement. 51 articles met the inclusion criteria. Only case reports, case series, and pharmacokinetic studies were identified, yielding a very low quality of evidence. Clinical data from 31 patients and toxicokinetic grading from 46 patients were abstracted. The workgroup concluded that phenytoin is moderately dialyzable (level of evidence = C) despite its high protein binding and made the following recommendations. ECTR would be reasonable in select cases of severe phenytoin poisoning (neutral recommendation, 3D). ECTR is suggested if prolonged coma is present or expected (graded 2D) and it would be reasonable if prolonged incapacitating ataxia is present or expected (graded 3D). If ECTR is used, it should be discontinued when clinical improvement is apparent (graded 1D). The preferred ECTR modality in phenytoin poisoning is intermittent hemodialysis (graded 1D), but hemoperfusion is an acceptable alternative if hemodialysis is not available (graded 1D). In summary, phenytoin appears to be amenable to extracorporeal removal. However, because of the low incidence of irreversible tissue injury or death related to phenytoin poisoning and the relatively limited effect of ECTR on phenytoin removal, the workgroup proposed the use of ECTR only in very select patients with severe phenytoin poisoning. Copyright © 2016 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Deep Web Search Interface Identification: A Semi-Supervised Ensemble Approach

OpenAIRE

Hong Wang; Qingsong Xu; Lifeng Zhou

2014-01-01

To surface the Deep Web, one crucial task is to predict whether a given web page has a search interface (searchable HyperText Markup Language (HTML) form) or not. Previous studies have focused on supervised classification with labeled examples. However, labeled data are scarce, hard to get and requires tediousmanual work, while unlabeled HTML forms are abundant and easy to obtain. In this research, we consider the plausibility of using both labeled and unlabeled data to train better models to...

Molecular organization in bacterial cell membranes. Specific labelling and topological distribution of glycoproteins and proteins in Streptomyces albus membranes

Energy Technology Data Exchange (ETDEWEB)

Larraga, V; Munoz, E [Consejo Superior de Investigaciones Cientificas, Madrid (Spain). Instituto de Biologia Celular

1975-05-01

The paper reports about an investigation into the question of the specific labelling and topological distribution of glycoproteins and proteins in Streptomyces albus membranes. The method of sample preparation is described: Tritium labelling of glycoproteins in protoplasts and membranes, iodination of proteins, trypsin treatment and polyacrylamide gel electrophoresis. The findings suggest an asymmetrical distribution of the glycoproteins in membranes and a weak accessibility to iodine label. A structural model of the plasma membranes of Streptomyces albus is proposed similar to the general 'fluid mosaic' model of Singer and Nicholson.

FDA Online Label Repository

Data.gov (United States)

U.S. Department of Health & Human Services — The drug labels and other drug-specific information on this Web site represent the most recent drug listing information companies have submitted to the Food and Drug...

The Planetary Data System Distributed Inventory System

Science.gov (United States)

Hughes, J. Steven; McMahon, Susan K.

1996-01-01

The advent of the World Wide Web (Web) and the ability to easily put data repositories on-line has resulted in a proliferation of digital libraries. The heterogeneity of the underlying systems, the autonomy of the individual sites, and distributed nature of the technology has made both interoperability across the sites and the search for resources within a site major research topics. This article will describe a system that addresses both issues using standard Web protocols and meta-data labels to implement an inventory of on-line resources across a group of sites. The success of this system is strongly dependent on the existence of and adherence to a standards architecture that guides the management of meta-data within participating sites.

Determination of the isotope distribution in 14C-labelled hydrocarbons by thermal fragmentation

International Nuclear Information System (INIS)

Kopinke, F.D.; Dermietzel, J.; Jockisch, W.; Raeuber, G.

1986-01-01

The gas chromatographic analysis of pyrolysis products of properly labelled hydrocarbons allows a definite and quantitative determination of the 14 C-distribution in those compounds. For this purpose a simple, fast, and versatilely applicable method has been developed and described

ClusterControl: a web interface for distributing and monitoring bioinformatics applications on a Linux cluster.

Science.gov (United States)

Stocker, Gernot; Rieder, Dietmar; Trajanoski, Zlatko

2004-03-22

ClusterControl is a web interface to simplify distributing and monitoring bioinformatics applications on Linux cluster systems. We have developed a modular concept that enables integration of command line oriented program into the application framework of ClusterControl. The systems facilitate integration of different applications accessed through one interface and executed on a distributed cluster system. The package is based on freely available technologies like Apache as web server, PHP as server-side scripting language and OpenPBS as queuing system and is available free of charge for academic and non-profit institutions. http://genome.tugraz.at/Software/ClusterControl

Impact of tobacco-related health warning labels across socioeconomic, race and ethnic groups: results from a randomized web-based experiment.

Directory of Open Access Journals (Sweden)

Jennifer Cantrell

Full Text Available BACKGROUND: The U.S. Family Smoking Prevention and Tobacco Control Act of 2009 requires updating of the existing text-only health warning labels on tobacco packaging with nine new warning statements accompanied by pictorial images. Survey and experimental research in the U.S. and other countries supports the effectiveness of pictorial health warning labels compared with text-only warnings for informing smokers about the risks of smoking and encouraging cessation. Yet very little research has examined differences in reactions to warning labels by race/ethnicity, education or income despite evidence that population subgroups may differ in their ability to process health information. The purpose of the present study was to evaluate the potential impact of pictorial warning labels compared with text-only labels among U.S. adult smokers from diverse racial/ethnic and socioeconomic subgroups. METHODS/FINDINGS: Participants were adult smokers recruited from two online research panels (n = 3,371 into a web-based experimental study to view either the new pictorial warnings or text-only warnings. Participants viewed the labels and reported their reactions. Adjusted regression models demonstrated significantly stronger reactions for the pictorial condition for each outcome salience (b = 0.62, p<.001; perceived impact (b = 0.44, p<.001; credibility (OR = 1.41, 95% CI = 1.22-1.62, and intention to quit (OR = 1.30, 95% CI = 1.10-1.53. No significant results were found for interactions between condition and race/ethnicity, education, or income. The only exception concerned the intention to quit outcome, where the condition-by-education interaction was nearly significant (p = 0.057. CONCLUSIONS: Findings suggest that the greater impact of the pictorial warning label compared to the text-only warning is consistent across diverse racial/ethnic and socioeconomic populations. Given their great reach, pictorial health warning labels may be one of the few tobacco

GlobAl Distribution of GEnetic Traits (GADGET) web server: polygenic trait scores worldwide.

Science.gov (United States)

Chande, Aroon T; Wang, Lu; Rishishwar, Lavanya; Conley, Andrew B; Norris, Emily T; Valderrama-Aguirre, Augusto; Jordan, I King

2018-05-18

Human populations from around the world show striking phenotypic variation across a wide variety of traits. Genome-wide association studies (GWAS) are used to uncover genetic variants that influence the expression of heritable human traits; accordingly, population-specific distributions of GWAS-implicated variants may shed light on the genetic basis of human phenotypic diversity. With this in mind, we developed the GlobAl Distribution of GEnetic Traits web server (GADGET http://gadget.biosci.gatech.edu). The GADGET web server provides users with a dynamic visual platform for exploring the relationship between worldwide genetic diversity and the genetic architecture underlying numerous human phenotypes. GADGET integrates trait-implicated single nucleotide polymorphisms (SNPs) from GWAS, with population genetic data from the 1000 Genomes Project, to calculate genome-wide polygenic trait scores (PTS) for 818 phenotypes in 2504 individual genomes. Population-specific distributions of PTS are shown for 26 human populations across 5 continental population groups, with traits ordered based on the extent of variation observed among populations. Users of GADGET can also upload custom trait SNP sets to visualize global PTS distributions for their own traits of interest.

Drug distribution in man: a positron emission tomography study after oral administration of the labelled neuroprotective drug vinpocetine

Energy Technology Data Exchange (ETDEWEB)

Gulyas, Balazs [Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, 171 76 Stockholm (Sweden); Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm (Sweden); Halldin, Christer; Sandell, Johan; Farde, Lars [Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, 171 76 Stockholm (Sweden); Sovago, Judit; Cselenyi, Zsolt [Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, 171 76 Stockholm (Sweden); Department of Neurology, Faculty of Medicine, University of Debrecen, Debrecen (Hungary); Vas, Adam; Kiss, Bela; Karpati, Egon [Chemical Works of Gedeon Richter Ltd., Budapest (Hungary)

2002-08-01

Direct information on the distribution of a drug requires measurements in various tissues. Such data have until now been obtained in animals, or have indirectly been calculated from plasma measurements in humans using mathematical models. Here we suggest the use of positron emission tomography (PET) as a method to obtain direct measurements of drug distribution in the human body. The distribution in body and brain of vinpocetine, a neuroprotective drug widely used in the prevention and treatment of cerebrovascular diseases, was followed after oral administration. Vinpocetine was labelled with carbon-11 and radioactivity was measured by PET in stomach, liver, brain and kidney in six healthy volunteers. The radioactivity in blood and urine as well as the fractions of [{sup 11}C]vinpocetine and labelled metabolites in plasma were also determined. After oral administration, [{sup 11}C]vinpocetine appeared immediately in the stomach and within minutes in the liver and the blood. In the blood the level of radioactivity continuously increased until the end of the measurement period, whereas the fraction of the unchanged mother compound decreased. Radioactivity uptake and distribution in the brain were demonstrable from the tenth minute after the administration of the labelled drug. Brain distribution was heterogeneous, similar to the distribution previously reported after intravenous administration. These findings indicate that vinpocetine, administered orally in humans, readily enters the bloodstream from the stomach and gastrointestinal tract and, consequently, passes the blood-brain barrier and enters the brain. Radioactivity from [{sup 11}C]vinpocetine was also demonstrated in the kidneys and in urine, indicating that at least a part of the radioactive drug and labelled metabolites is eliminated from the body through the kidneys. This study is the first to demonstrate that PET might be a useful, direct and non-invasive tool to study the distribution and

Development of a web service for analysis in a distributed network.

Science.gov (United States)

Jiang, Xiaoqian; Wu, Yuan; Marsolo, Keith; Ohno-Machado, Lucila

2014-01-01

We describe functional specifications and practicalities in the software development process for a web service that allows the construction of the multivariate logistic regression model, Grid Logistic Regression (GLORE), by aggregating partial estimates from distributed sites, with no exchange of patient-level data. We recently developed and published a web service for model construction and data analysis in a distributed environment. This recent paper provided an overview of the system that is useful for users, but included very few details that are relevant for biomedical informatics developers or network security personnel who may be interested in implementing this or similar systems. We focus here on how the system was conceived and implemented. We followed a two-stage development approach by first implementing the backbone system and incrementally improving the user experience through interactions with potential users during the development. Our system went through various stages such as concept proof, algorithm validation, user interface development, and system testing. We used the Zoho Project management system to track tasks and milestones. We leveraged Google Code and Apache Subversion to share code among team members, and developed an applet-servlet architecture to support the cross platform deployment. During the development process, we encountered challenges such as Information Technology (IT) infrastructure gaps and limited team experience in user-interface design. We figured out solutions as well as enabling factors to support the translation of an innovative privacy-preserving, distributed modeling technology into a working prototype. Using GLORE (a distributed model that we developed earlier) as a pilot example, we demonstrated the feasibility of building and integrating distributed modeling technology into a usable framework that can support privacy-preserving, distributed data analysis among researchers at geographically dispersed institutes.

Development of a Web Service for Analysis in a Distributed Network

Science.gov (United States)

Jiang, Xiaoqian; Wu, Yuan; Marsolo, Keith; Ohno-Machado, Lucila

2014-01-01

Objective: We describe functional specifications and practicalities in the software development process for a web service that allows the construction of the multivariate logistic regression model, Grid Logistic Regression (GLORE), by aggregating partial estimates from distributed sites, with no exchange of patient-level data. Background: We recently developed and published a web service for model construction and data analysis in a distributed environment. This recent paper provided an overview of the system that is useful for users, but included very few details that are relevant for biomedical informatics developers or network security personnel who may be interested in implementing this or similar systems. We focus here on how the system was conceived and implemented. Methods: We followed a two-stage development approach by first implementing the backbone system and incrementally improving the user experience through interactions with potential users during the development. Our system went through various stages such as concept proof, algorithm validation, user interface development, and system testing. We used the Zoho Project management system to track tasks and milestones. We leveraged Google Code and Apache Subversion to share code among team members, and developed an applet-servlet architecture to support the cross platform deployment. Discussion: During the development process, we encountered challenges such as Information Technology (IT) infrastructure gaps and limited team experience in user-interface design. We figured out solutions as well as enabling factors to support the translation of an innovative privacy-preserving, distributed modeling technology into a working prototype. Conclusion: Using GLORE (a distributed model that we developed earlier) as a pilot example, we demonstrated the feasibility of building and integrating distributed modeling technology into a usable framework that can support privacy-preserving, distributed data analysis among

Web services foundations

CERN Document Server

Bouguettaya, Athman; Daniel, Florian

2013-01-01

Web services and Service-Oriented Computing (SOC) have become thriving areas of academic research, joint university/industry research projects, and novel IT products on the market. SOC is the computing paradigm that uses Web services as building blocks for the engineering of composite, distributed applications out of the reusable application logic encapsulated by Web services. Web services could be considered the best-known and most standardized technology in use today for distributed computing over the Internet.Web Services Foundations is the first installment of a two-book collection coverin

Measurement of inhomogeneous activity distribution in paper chromatography using 131I-labelled rose bengal

International Nuclear Information System (INIS)

Strietzel, M.

1976-01-01

The inhomogeneous activity distribution of 131 I-labelled rose bengal after paper chromatographic separation has been evaluated. Superposing autoradiograms obtained by different exposure times on the original strip, the fraction boundaries are transferred to the latter and cut out. The cuttings are measured in an automatic sample changer under constant geometrical conditions. The methodical error ranges from 5 to 10 per cent. This method was used to test the stability of 131 I-labelled rose bengal over a period of 4 to 5 half-lives

Psychosocial safety climate moderates the job demand-resource interaction in predicting workgroup distress.

Science.gov (United States)

Dollard, Maureen F; Tuckey, Michelle R; Dormann, Christian

2012-03-01

Psychosocial safety climate (PSC) arises from workplace policies, practices, and procedures for the protection of worker psychological health and safety that are largely driven by management. Many work stress theories are based on the fundamental interaction hypothesis - that a high level of job demands (D) will lead to psychological distress and that this relationship will be offset when there are high job resources (R). However we proposed that this interaction really depends on the organizational context; in particular high levels of psychosocial safety climate will enable the safe utilization of resources to reduce demands. The study sample consisted of police constables from 23 police units (stations) with longitudinal survey responses at two time points separated by 14 months (Time 1, N=319, Time 2, N=139). We used hierarchical linear modeling to assess the effect of the proposed three-way interaction term (PSC×D×R) on change in workgroup distress variance over time. Specifically we confirmed the interaction between emotional demands and emotional resources (assessed at the individual level), in the context of unit psychosocial safety climate (aggregated individual data). As predicted, high emotional resources moderated the positive relationship between emotional demands and change in workgroup distress but only when there were high levels of unit psychosocial safety climate. Results were confirmed using a split-sample analysis. Results support psychosocial safety climate as a property of the organization and a target for higher order controls for reducing work stress. The 'right' climate enables resources to do their job. Copyright © 2011 Elsevier Ltd. All rights reserved.

BioAtlas: Interactive web service for microbial distribution analysis

DEFF Research Database (Denmark)

Lund, Jesper; List, Markus; Baumbach, Jan

Massive amounts of 16S rRNA sequencing data have been stored in publicly accessible databases, such as GOLD, SILVA, GreenGenes (GG), and the Ribosomal Database Project (RDP). Many of these sequences are tagged with geo-locations. Nevertheless, researchers currently lack a user-friendly tool...... to analyze microbial distribution in a location-specific context. BioAtlas is an interactive web application that closes this gap between sequence databases, taxonomy profiling and geo/body-location information. It enables users to browse taxonomically annotated sequences across (i) the world map, (ii) human...

Distribution of 131 I- labeled Bothrops erythromelas venom in mice

International Nuclear Information System (INIS)

Vasconcelos, C.M.L.; Valenca, R.C.; Araujo, E.A.; Modesto, J.C.A.; Pontes, M.M.; Guarnieri, M.C.; Brazil, T.K.

1998-01-01

Bothrops erythromelas is responsible for many snake bites in northeastern Brazil. In the present study we determined the in vivo distribution of the venom following its subcutaneous injection into mice. B. erythromelas venom and albumin were labeled individually with 131 I by the chloramine T method, and separated in a Sephacryl S-200 column. The efficiency of labeling was 68%.Male Swiss mice (40-45 g), which had been provided with drinking water containing 0.05% KI over a period of 10 days prior to the experiment, were inoculated dorsally (sc) with 0.3 ml (2.35 x 10 5 cpm/mouse) of 131 I-venom (N = 42), 131 -albumin or 131 I (controls, N = 28 each). Thirty minutes and 1,3, 6, 12, 18 and 24 h after inoculation, the animals were perfused with 0.85% Na Cl and skin and various organs were collected in order to determine radioactivity content. There was a high rate of venom absorption int he skin (51%) within the first 30 min compared to albumin (20.1%) and free iodine (8.2%). Up to the third hour after injection there was a tendency for venom and albumin to concentrate in the stomach ( 3 rd h),small intestine (3 rd h) and large intestine (6th h). Both control groups had more radioactivity in the digestive tract, especially in the stomach, but these levels decreased essentially to baseline by 12-18 h postinjection. In the kidneys, the distribution profiles of venom, albumin and iodine were similar. Counts at 30 min postinjection were low in all three groups (1.37, 1.86 and 0.77, respectively), and diminished to essentially 0% by 12-18 h. Albumin tended to concentrate in muscle until the 3 rd h postinjection (1.98%).There was a low binding of labeled venom in the liver (B. erythromelas venom does not specifically target most internal organs. That is, the systemic effects of envenomation ar mainly due to an indirect action. (author)

Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society.

Science.gov (United States)

Seaquist, Elizabeth R; Anderson, John; Childs, Belinda; Cryer, Philip; Dagogo-Jack, Samuel; Fish, Lisa; Heller, Simon R; Rodriguez, Henry; Rosenzweig, James; Vigersky, Robert

2013-05-01

To review the evidence about the impact of hypoglycemia on patients with diabetes that has become available since the past reviews of this subject by the American Diabetes Association and The Endocrine Society and to provide guidance about how this new information should be incorporated into clinical practice. Five members of the American Diabetes Association and five members of The Endocrine Society with expertise in different aspects of hypoglycemia were invited by the Chair, who is a member of both, to participate in a planning conference call and a 2-day meeting that was also attended by staff from both organizations. Subsequent communications took place via e-mail and phone calls. The writing group consisted of those invitees who participated in the writing of the manuscript. The workgroup meeting was supported by educational grants to the American Diabetes Association from Lilly USA, LLC and Novo Nordisk and sponsorship to the American Diabetes Association from Sanofi. The sponsors had no input into the development of or content of the report. The writing group considered data from recent clinical trials and other studies to update the prior workgroup report. Unpublished data were not used. Expert opinion was used to develop some conclusions. Consensus was achieved by group discussion during conference calls and face-to-face meetings, as well as by iterative revisions of the written document. The document was reviewed and approved by the American Diabetes Association's Professional Practice Committee in October 2012 and approved by the Executive Committee of the Board of Directors in November 2012 and was reviewed and approved by The Endocrine Society's Clinical Affairs Core Committee in October 2012 and by Council in November 2012. The workgroup reconfirmed the previous definitions of hypoglycemia in diabetes, reviewed the implications of hypoglycemia on both short- and long-term outcomes, considered the implications of hypoglycemia on treatment outcomes

Pharmacotherapy of Traumatic Brain Injury: State of the Science and the Road Forward: Report of the Department of Defense Neurotrauma Pharmacology Workgroup

Science.gov (United States)

Kochanek, Patrick M.; Bergold, Peter; Kenney, Kimbra; Marx, Christine E.; Grimes, Col. Jamie B.; Loh, LTC Yince; Adam, LTC Gina E.; Oskvig, Devon; Curley, Kenneth C.; Salzer, Col. Wanda

2014-01-01

Abstract Despite substantial investments by government, philanthropic, and commercial sources over the past several decades, traumatic brain injury (TBI) remains an unmet medical need and a major source of disability and mortality in both developed and developing societies. The U.S. Department of Defense neurotrauma research portfolio contains more than 500 research projects funded at more than $700 million and is aimed at developing interventions that mitigate the effects of trauma to the nervous system and lead to improved quality of life outcomes. A key area of this portfolio focuses on the need for effective pharmacological approaches for treating patients with TBI and its associated symptoms. The Neurotrauma Pharmacology Workgroup was established by the U.S. Army Medical Research and Materiel Command (USAMRMC) with the overarching goal of providing a strategic research plan for developing pharmacological treatments that improve clinical outcomes after TBI. To inform this plan, the Workgroup (a) assessed the current state of the science and ongoing research and (b) identified research gaps to inform future development of research priorities for the neurotrauma research portfolio. The Workgroup identified the six most critical research priority areas in the field of pharmacological treatment for persons with TBI. The priority areas represent parallel efforts needed to advance clinical care; each requires independent effort and sufficient investment. These priority areas will help the USAMRMC and other funding agencies strategically guide their research portfolios to ensure the development of effective pharmacological approaches for treating patients with TBI. PMID:23968241

Retrieval-based Face Annotation by Weak Label Regularized Local Coordinate Coding.

Science.gov (United States)

Wang, Dayong; Hoi, Steven C H; He, Ying; Zhu, Jianke; Mei, Tao; Luo, Jiebo

2013-08-02

Retrieval-based face annotation is a promising paradigm of mining massive web facial images for automated face annotation. This paper addresses a critical problem of such paradigm, i.e., how to effectively perform annotation by exploiting the similar facial images and their weak labels which are often noisy and incomplete. In particular, we propose an effective Weak Label Regularized Local Coordinate Coding (WLRLCC) technique, which exploits the principle of local coordinate coding in learning sparse features, and employs the idea of graph-based weak label regularization to enhance the weak labels of the similar facial images. We present an efficient optimization algorithm to solve the WLRLCC task. We conduct extensive empirical studies on two large-scale web facial image databases: (i) a Western celebrity database with a total of $6,025$ persons and $714,454$ web facial images, and (ii)an Asian celebrity database with $1,200$ persons and $126,070$ web facial images. The encouraging results validate the efficacy of the proposed WLRLCC algorithm. To further improve the efficiency and scalability, we also propose a PCA-based approximation scheme and an offline approximation scheme (AWLRLCC), which generally maintains comparable results but significantly saves much time cost. Finally, we show that WLRLCC can also tackle two existing face annotation tasks with promising performance.

Advanced web services

CERN Document Server

Bouguettaya, Athman; Daniel, Florian

2013-01-01

Web services and Service-Oriented Computing (SOC) have become thriving areas of academic research, joint university/industry research projects, and novel IT products on the market. SOC is the computing paradigm that uses Web services as building blocks for the engineering of composite, distributed applications out of the reusable application logic encapsulated by Web services. Web services could be considered the best-known and most standardized technology in use today for distributed computing over the Internet. This book is the second installment of a two-book collection covering the state-o

Spine labeling in MRI via regularized distribution matching.

Science.gov (United States)

Hojjat, Seyed-Parsa; Ayed, Ismail; Garvin, Gregory J; Punithakumar, Kumaradevan

2017-11-01

This study investigates an efficient (nearly real-time) two-stage spine labeling algorithm that removes the need for an external training while being applicable to different types of MRI data and acquisition protocols. Based solely on the image being labeled (i.e., we do not use training data), the first stage aims at detecting potential vertebra candidates following the optimization of a functional containing two terms: (i) a distribution-matching term that encodes contextual information about the vertebrae via a density model learned from a very simple user input, which amounts to a point (mouse click) on a predefined vertebra; and (ii) a regularization constraint, which penalizes isolated candidates in the solution. The second stage removes false positives and identifies all vertebrae and discs by optimizing a geometric constraint, which embeds generic anatomical information on the interconnections between neighboring structures. Based on generic knowledge, our geometric constraint does not require external training. We performed quantitative evaluations of the algorithm over a data set of 90 mid-sagittal MRI images of the lumbar spine acquired from 45 different subjects. To assess the flexibility of the algorithm, we used both T1- and T2-weighted images for each subject. A total of 990 structures were automatically detected/labeled and compared to ground-truth annotations by an expert. On the T2-weighted data, we obtained an accuracy of 91.6% for the vertebrae and 89.2% for the discs. On the T1-weighted data, we obtained an accuracy of 90.7% for the vertebrae and 88.1% for the discs. Our algorithm removes the need for external training while being applicable to different types of MRI data and acquisition protocols. Based on the current testing data, a subject-specific model density and generic anatomical information, our method can achieve competitive performances when applied to T1- and T2-weighted MRI images.

Distributed Deep Web Search

NARCIS (Netherlands)

Tjin-Kam-Jet, Kien

2013-01-01

The World Wide Web contains billions of documents (and counting); hence, it is likely that some document will contain the answer or content you are searching for. While major search engines like Bing and Google often manage to return relevant results to your query, there are plenty of situations in

Engineering Web Applications

DEFF Research Database (Denmark)

Casteleyn, Sven; Daniel, Florian; Dolog, Peter

Nowadays, Web applications are almost omnipresent. The Web has become a platform not only for information delivery, but also for eCommerce systems, social networks, mobile services, and distributed learning environments. Engineering Web applications involves many intrinsic challenges due...... to their distributed nature, content orientation, and the requirement to make them available to a wide spectrum of users who are unknown in advance. The authors discuss these challenges in the context of well-established engineering processes, covering the whole product lifecycle from requirements engineering through...... design and implementation to deployment and maintenance. They stress the importance of models in Web application development, and they compare well-known Web-specific development processes like WebML, WSDM and OOHDM to traditional software development approaches like the waterfall model and the spiral...

Distribution kinetics of 3H-labelled p-phenylene diamine - - a hair dye

International Nuclear Information System (INIS)

Rehani, M.M.; Jain, I.S.; Sharma, S.K.

1981-01-01

The distribution kinetics of the 3 H-labelled p-phenylene diamine (a hair dye compound), was studied when administered iv and when applied percutaneously. The tracer experiments in rabbits after iv administration showed a biphasic blood clearance with half life values of 24 min and 43.5 h and quick-percutaneous absorption. The tissue distribution pattern investigated after iv and percutaneous administration in 16 different tissues and also in blood did not demonstrate any target organ for selective localisation of the dye. Not more than 0.06 percent of the iv administered radioactivity was measured per 10 mg of any tissue at 12th day. (author)

Use of the Web by a Distributed Research group Performing Distributed Computing

Science.gov (United States)

Burke, David A.; Peterkin, Robert E.

2001-06-01

A distributed research group that uses distributed computers faces a spectrum of challenges--some of which can be met by using various electronic means of communication. The particular challenge of our group involves three physically separated research entities. We have had to link two collaborating groups at AFRL and NRL together for software development, and the same AFRL group with a LANL group for software applications. We are developing and using a pair of general-purpose, portable, parallel, unsteady, plasma physics simulation codes. The first collaboration is centered around a formal weekly video teleconference on relatively inexpensive equipment that we have set up in convenient locations in our respective laboratories. The formal virtual meetings are augmented with informal virtual meetings as the need arises. Both collaborations share research data in a variety of forms on a secure URL that is set up behind the firewall at the AFRL. Of course, a computer-generated animation is a particularly efficient way of displaying results from time-dependent numerical simulations, so we generally like to post such animations (along with proper documentation) on our web page. In this presentation, we will discuss some of our accomplishments and disappointments.

Distribution of 131I-labeled recombinant human erythropoietin in maternal and fetal organs following intravenous administration in pregnant rats

International Nuclear Information System (INIS)

Yilmaz, O.; Lambrecht, F.Y.; Durkan, K.; Gokmen, N.; Erbayraktar, S.

2007-01-01

The aim of the present study was to demonstrate the possible transplacental transmission of 131 I labeled recombinant human erythropoietin ( 131 I-rh-EPO) in pregnant rats and its distribution through maternal and fetal organs. Six Wistar Albino Rats in their pregnancy of 18 days were used 131 I labeled recombinant human erythropoietin (specific activity = 2.4 μCi/IU) was injected into the tail vein of rats. After 30 minutes labeled erythropoietin infusion maternal stomach, kidney, lung, liver, brain and heart as well as fetus were removed. Then, the same organs were removed from each fetus. Measuring weight of maternal and fetal organs as well as placenta were followed by radioactivity count via Cd(Te) detector. 131 I labeled recombinant human erythropoietin was found to be able to pass rat placenta and its distribution order in fetal organs was similar to those of maternal organs. Besides, as measurements were performed closer to cornu uteri, uptakes were decreasing in every fetus and its corresponding placenta. (author)

Indications for CT and MR arthrography. Recommendations of the Musculoskeletal Workgroup of the DRG; Indikationen der MR- und CT-Arthrografie. Empfehlungen der AG Muskuloskelettale Radiologie der DRG

Energy Technology Data Exchange (ETDEWEB)

Fischer, W. [Hessingpark Clinic, Radiologengemeinschaft Augsburg (Germany); Bohndorf, K.; Zentner, J. [Zentralklinikum Augsburg (Germany). Klinik fuer Diagnostische Radiologie und Neuroradiologie; Kreitner, K.F. [Universitaetsklinikum Mainz (Germany). Klinik und Poliklinik fuer Radiologie; Schmitt, R. [Herz- und Gefaessklinik GmbH, Bad Neustadt an der Saale (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie; Woertler, K. [Klinikum rechts der Isar, Muenchen (Germany). Inst. fuer Roentgendiagnostik

2009-05-15

The ongoing discussion about CT and MR arthrography is at least in part due to the lack of definite guidelines. The intention of the musculoskeletal workgroup of the DRG (Deutsche Roentgengesellschaft) was the establishment of recommendations for general guidance. After review of the recent literature, the indications for arthrographic examinations were discussed during a consensus meeting. Since the published data are insufficient and partially contradictory, no precise statements could be extracted from the literature. Therefore, the proposed recommendations are mainly based on expert opinions. In this review the main statements of the published literature are summarized and the recommendations of the musculoskeletal workgroup of the DRG are presented. (orig.)

Evaluation of radiological workstations and web-browser-based image distribution clients for a PACS project in hands-on workshops

International Nuclear Information System (INIS)

Boehm, Thomas; Handgraetinger, Oliver; Voellmy, Daniel R.; Marincek, Borut; Wildermuth, Simon; Link, Juergen; Ploner, Ricardo

2004-01-01

The methodology and outcome of a hands-on workshop for the evaluation of PACS (picture archiving and communication system) software for a multihospital PACS project are described. The following radiological workstations and web-browser-based image distribution software clients were evaluated as part of a multistep evaluation of PACS vendors in March 2001: Impax DS 3000 V 4.1/Impax Web1000 (Agfa-Gevaert, Mortsel, Belgium); PathSpeed V 8.0/PathSpeed Web (GE Medical Systems, Milwaukee, Wis., USA); ID Report/ID Web (Image Devices, Idstein, Germany); EasyVision DX/EasyWeb (Philips Medical Systems, Eindhoven, Netherlands); and MagicView 1000 VB33a/MagicWeb (Siemens Medical Systems, Erlangen, Germany). A set of anonymized DICOM test data was provided to enable direct image comparison. Radiologists (n=44) evaluated the radiological workstations and nonradiologists (n=53) evaluated the image distribution software clients using different questionnaires. One vendor was not able to import the provided DICOM data set. Another vendor had problems in displaying imported cross-sectional studies in the correct stack order. Three vendors (Agfa-Gevaert, GE, Philips) presented server-client solutions with web access. Two (Siemens, Image Devices) presented stand-alone solutions. The highest scores in the class of radiological workstations were achieved by ID Report from Image Devices (p<0.005). In the class of image distribution clients, the differences were statistically not significant. Questionnaire-based evaluation was shown to be useful for guaranteeing systematic assessment. The workshop was a great success in raising interest in the PACS project in a large group of future clinical users. The methodology used in the present study may be useful for other hospitals evaluating PACS. (orig.)

Building web information systems using web services

NARCIS (Netherlands)

Frasincar, F.; Houben, G.J.P.M.; Barna, P.; Vasilecas, O.; Eder, J.; Caplinskas, A.

2006-01-01

Hera is a model-driven methodology for designing Web information systems. In the past a CASE tool for the Hera methodology was implemented. This software had different components that together form one centralized application. In this paper, we present a distributed Web service-oriented architecture

New distributive web-caching technique for VOD services

Science.gov (United States)

Kim, Iksoo; Woo, Yoseop; Hwang, Taejune; Choi, Jintak; Kim, Youngjune

2002-12-01

At present, one of the most popular services through internet is on-demand services including VOD, EOD and NOD. But the main problems for on-demand service are excessive load of server and insufficiency of network resources. Therefore the service providers require a powerful expensive server and clients are faced with long end-to-end delay and network congestion problem. This paper presents a new distributive web-caching technique for fluent VOD services using distributed proxies in Head-end-Network (HNET). The HNET consists of a Switching-Agent (SA) as a control node, some Head-end Nodes (HEN) as proxies and clients connected to HEN. And each HEN is composing a LAN. Clients request VOD services to server through a HEN and SA. The SA operates the heart of HNET, all the operations using proposed distributive caching technique perform under the control of SA. This technique stores some parts of a requested video on the corresponding HENs when clients connected to each HEN request an identical video. Thus, clients access those HENs (proxies) alternatively for acquiring video streams. Eventually, this fact leads to equi-loaded proxy (HEN). We adopt the cache replacement strategy using the combination of LRU, LFU, remove streams from other HEN prior to server streams and the method of replacing the first block of video last to reduce end-to end delay.

WebFTS: File Transfer Web Interface for FTS3

CERN Multimedia

CERN. Geneva

2014-01-01

WebFTS is a web-delivered file transfer and management solution which allows users to invoke reliable, managed data transfers on distributed infrastructures. The fully open source solution offers a simple graphical interface through which the power of the FTS3 service can be accessed without the installation of any special grid tools. Created following simplicity and efficiency criteria, WebFTS allows the user to access and interact with multiple grid and cloud storage. The “transfer engine” used is FTS3, the service responsible for distributing the majority of LHC data across WLCG infrastructure. This provides WebFTS with reliable, multi-protocol, adaptively optimised data transfers.The talk will focus on the recent development which allows transfers from/to Dropbox and CERNBox (CERN ownCloud deployment)

Tropanol esters of metallocene carboxylic acids. Syntheses, labelling with 103Ru and sup(103m)Rh and organ distribution

International Nuclear Information System (INIS)

Wenzel, M.; Wu, Y.

1988-01-01

The tropanol esters of the carboxylic acids of ferrocene, 103 Ru-ruthenocene and sup(103m)Rh-rhodocinium were synthezised. The organ distribution of the 103 Ru or sup(103m)Rh labelled tropanol-esters were investigated. Only the 103 Ru labelled ester showed a high heart/blood ratio. (author)

Deep Web Search Interface Identification: A Semi-Supervised Ensemble Approach

Directory of Open Access Journals (Sweden)

Hong Wang

2014-12-01

Full Text Available To surface the Deep Web, one crucial task is to predict whether a given web page has a search interface (searchable HyperText Markup Language (HTML form or not. Previous studies have focused on supervised classification with labeled examples. However, labeled data are scarce, hard to get and requires tediousmanual work, while unlabeled HTML forms are abundant and easy to obtain. In this research, we consider the plausibility of using both labeled and unlabeled data to train better models to identify search interfaces more effectively. We present a semi-supervised co-training ensemble learning approach using both neural networks and decision trees to deal with the search interface identification problem. We show that the proposed model outperforms previous methods using only labeled data. We also show that adding unlabeled data improves the effectiveness of the proposed model.

An empirical study on how the distribution of ontologies affects reasoning on the web

NARCIS (Netherlands)

Bazoobandi, Hamid R.; Urbani, Jacopo; van Harmelen, Frank; Bal, Henri

2017-01-01

The Web of Data is an inherently distributed environment where ontologies are located in (physically) remote locations and are subject to constant changes. Reasoning is affected by these changes, but the extent and significance of this dependency is not well-studied yet. To address this problem,

Web-Based Course Management and Web Services

Science.gov (United States)

Mandal, Chittaranjan; Sinha, Vijay Luxmi; Reade, Christopher M. P.

2004-01-01

The architecture of a web-based course management tool that has been developed at IIT [Indian Institute of Technology], Kharagpur and which manages the submission of assignments is discussed. Both the distributed architecture used for data storage and the client-server architecture supporting the web interface are described. Further developments…

Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo.

Science.gov (United States)

Roelofs, Anke J; Stewart, Charlotte A; Sun, Shuting; Błażewska, Katarzyna M; Kashemirov, Boris A; McKenna, Charles E; Russell, R Graham G; Rogers, Michael J; Lundy, Mark W; Ebetino, Frank H; Coxon, Fraser P

2012-04-01

Bisphosphonates are widely used antiresorptive drugs that bind to calcium. It has become evident that these drugs have differing affinities for bone mineral; however, it is unclear whether such differences affect their distribution on mineral surfaces. In this study, fluorescent conjugates of risedronate, and its lower-affinity analogues deoxy-risedronate and 3-PEHPC, were used to compare the localization of compounds with differing mineral affinities in vivo. Binding to dentine in vitro confirmed differences in mineral binding between compounds, which was influenced predominantly by the characteristics of the parent compound but also by the choice of fluorescent tag. In growing rats, all compounds preferentially bound to forming endocortical as opposed to resorbing periosteal surfaces in cortical bone, 1 day after administration. At resorbing surfaces, lower-affinity compounds showed preferential binding to resorption lacunae, whereas the highest-affinity compound showed more uniform labeling. At forming surfaces, penetration into the mineralizing osteoid was found to inversely correlate with mineral affinity. These differences in distribution at resorbing and forming surfaces were not observed at quiescent surfaces. Lower-affinity compounds also showed a relatively higher degree of labeling of osteocyte lacunar walls and labeled lacunae deeper within cortical bone, indicating increased penetration of the osteocyte canalicular network. Similar differences in mineralizing surface and osteocyte network penetration between high- and low-affinity compounds were evident 7 days after administration, with fluorescent conjugates at forming surfaces buried under a new layer of bone. Fluorescent compounds were incorporated into these areas of newly formed bone, indicating that "recycling" had occurred, albeit at very low levels. Taken together, these findings indicate that the bone mineral affinity of bisphosphonates is likely to influence their distribution within the

US EPA Regional Masks Web Service, US, 2015, US EPA, SEGS

Data.gov (United States)

U.S. Environmental Protection Agency — This web service contains the following map layers: masks and labels for EPA regions 1 through 10. Mask layers are drawn at all scales. Label layers draw at scales...

Research Proposal for Distributed Deep Web Search

NARCIS (Netherlands)

Tjin-Kam-Jet, Kien

2010-01-01

This proposal identifies two main problems related to deep web search, and proposes a step by step solution for each of them. The first problem is about searching deep web content by means of a simple free-text interface (with just one input field, instead of a complex interface with many input

Central transport and distribution of labelled glutamic and aspartic acids to the cochlear nucleus in cats

International Nuclear Information System (INIS)

Kane, E.S.

1979-01-01

Tritiated L-glutamic acid or L-aspartic acid was injected unilaterally into the cochleas of adult cats, and 4 h-7 days later the localization of label was studied by light-microscopic autoradiography in sections of the brain stem. Consistent differences in labelling after glutamate and after aspartate suggest differences in their uptake, metabolic conversion and/or transport to the cochlear nucleus by cochlear fibers. The morphological differences shown here agree with the distribution of those two amino acids in the cat cochlear nucleus as shown by microchemical analyses. (author)

AFEM Consensus Conference, 2013. AFEM Out-of-Hospital Emergency Care Workgroup Consensus Paper: Advancing Out-of-Hospital Emergency Care in Africa-Advocacy and Development

Directory of Open Access Journals (Sweden)

N.K. Mould-Millman

2014-06-01

Future directions of the AFEM Out-of-Hospital Emergency Care Workgroup include creating an online Toolkit. This will serve as a repository of template documents to guide implementation and development of clinical care, education, transportation, public access, policy and governance.

Web party effect: a cocktail party effect in the web environment.

Science.gov (United States)

Rigutti, Sara; Fantoni, Carlo; Gerbino, Walter

2015-01-01

In goal-directed web navigation, labels compete for selection: this process often involves knowledge integration and requires selective attention to manage the dizziness of web layouts. Here we ask whether the competition for selection depends on all web navigation options or only on those options that are more likely to be useful for information seeking, and provide evidence in favor of the latter alternative. Participants in our experiment navigated a representative set of real websites of variable complexity, in order to reach an information goal located two clicks away from the starting home page. The time needed to reach the goal was accounted for by a novel measure of home page complexity based on a part of (not all) web options: the number of links embedded within web navigation elements weighted by the number and type of embedding elements. Our measure fully mediated the effect of several standard complexity metrics (the overall number of links, words, images, graphical regions, the JPEG file size of home page screenshots) on information seeking time and usability ratings. Furthermore, it predicted the cognitive demand of web navigation, as revealed by the duration judgment ratio (i.e., the ratio of subjective to objective duration of information search). Results demonstrate that focusing on relevant links while ignoring other web objects optimizes the deployment of attentional resources necessary to navigation. This is in line with a web party effect (i.e., a cocktail party effect in the web environment): users tune into web elements that are relevant for the achievement of their navigation goals and tune out all others.

Hypoxia marker labeling in tumor biopsies: quantification of labeling variation and criteria for biopsy sectioning

International Nuclear Information System (INIS)

Thrall, Donald E.; Rosner, Gary L.; Azuma, Chieko; McEntee, Margaret C.; Raleigh, James A.

1997-01-01

Background and purpose: The error associated with using biopsy-based methods for assessing parameters reflective of the tumor microenvironment depends on the variability in distribution of the parameter throughout the tumor and the biopsy sample. Some attention has been given to intratumoral distribution of parameters, but little attention has been given to their intrabiopsy distribution. We evaluated the intrabiopsy distribution of CCI-103F, a 2-nitroimidazole hypoxia marker. Materials and methods: The hypoxia marker CCI-103F was studied in dogs bearing spontaneous solid tumors. Two biopsies were taken from each of seven tumors, for a total of 14 biopsies. Biopsies were serially sectioned and four to six contiguous slides from each 100-150 μm of the biopsy were used to formulate the best estimate of CCI-103F labeled area throughout the biopsy sample. One, two or four slides were then randomly selected from each biopsy and the labeled area, based on this limited sample, was compared to the estimate obtained from counting all available slides. Random sampling of slides was repeated 1000 times for each biopsy sample. Results: CCI-103F labeling variance throughout the biopsy decreased as the estimated overall labeled area in the biopsy decreased. The error associated with estimating the overall labeled area in a biopsy from a randomly selected subset of slides decreased as the number of slides increased, and as the overall labeled area in the biopsy decreased. No minimally labeled biopsy was classified as unlabeled based on limited sampling. Conclusion: With regard to CCI-103F labeling, quantification of the labeled area in four randomly selected slides from a biopsy can provide, in most biopsies, an estimate of the labeled area in the biopsy within an absolute range of ±0.05

Distribution, and uptake by rice plants of 15N-labeled ammonium applied in mudballs in paddy soils

International Nuclear Information System (INIS)

Ventura, Wilbur; Yoshida, Tomio

1978-01-01

A 1974 field experiment determined the distribution, and uptake by rice plants, of ammonium fertilizer at 60 kg N/ha applied in mudballs into the reduced layer of paddy soil. The fertilizer-carrying mudballs were placed at the center of four hills. At the center of the plot, one 15 N-labeled mudball was applied and the 15 N content of the plants surrounding the site of placement were determined. For comparison, labeled ammonium fertilizer was basally incorporated with the entire puddled layer and a topdress application was made 39 days before heading. There was little movement of the ammonium nitrogen horizontally from the site of placement so that the distribution of 15 N was restricted to the four adjacent plant hills. The distribution of incorporated ammonium fertilizer with the puddled layer was likewise restricted to the four adjacent rice plants but topdressing, with the unavoidable disturbance of the floodwater, resulted to a wide distribution of the 15 N-labeled fertilizer. In all the methods of application, there was an uneven uptake of 15 N among four plants adjacent to the site of placement. An increase of at least 10% in the efficiency of ammonium fertilizer was obtained by the deep placement of ammoniated mudballs as compared to the common practice of incorporating the fertilizer with the puddled soil layer. Topdressing at 39 days before heading, however, was as efficient as mudballs applied at the same stage of growth. There was no significant increase in grain yield by deep placement of fertilizer because of the high initial nitrogen content of the soil. (author)

Location-Based Mapping Services to Support Collaboration in Spatially Distributed Workgroups

Science.gov (United States)

Meyer, Eike Michael; Wichmann, Daniel; Büsch, Henning; Boll, Susanne

Mobile devices and systems reached almost every part of our daily life. Following the mobile computing trend, also business logics of distributed, cooperative applications started to move into the mobile client applications. With this shift, the cooperation aspect may also exploit the user’s location and situation context and capabilities of the mobile device and integrate it into the actual cooperation and collaboration. In this paper, we present an approach for a Collaborative Map that exploits the spatial context of the member of a distributed group as a means to visualize and provide collaboration functionality. Then, a number of location-related cooperation methods become feasible such as getting an overview of the spatial distribution of the team members, identify an ad-hoc meeting place nearby, or chat with a group member who has a certain expertise in his or her profile. With CoMa, we move from standard collaboration tools that marginally consider spatial information towards context-aware mobile collaborative systems that can support a wide range of applications such as emergency response, maintenance work or event organization where human resources have to be coordinated in a spatial context and tasks need to be assigned dynamically depending on capabilities and situation context.

Determination of one-dimensional distribution of 14C-labelled compounds

International Nuclear Information System (INIS)

Rexa, R.; Kron, I.; Kralik, P.; Tykva, R.

1988-01-01

Three methods used for the determination of one-dimensional distribution of 14 C-labelled compounds are compared: measurement with position-sensitive detector (LB 282/511), liquid scintillation counting (LSC), and autoradiography with densitometric quantification. For a mutual comparison of these methods samples of blood serum were used, in which the fractional esterification rate (FER) was determined by means of LCAT Test. The agreement of the methods of FER determination on the basis of the measurement with LB 282/511 or LSC was checked. In the case of autoradiography a correction for non-linearity between the blackening and the number of β-particles striking the area unit was necessary. (author) 5 refs.; 5 figs

Gender-specific research for emergency diagnosis and management of ischemic heart disease: proceedings from the 2014 Academic Emergency Medicine Consensus Conference Cardiovascular Research Workgroup.

Science.gov (United States)

Safdar, Basmah; Nagurney, John T; Anise, Ayodola; DeVon, Holli A; D'Onofrio, Gail; Hess, Erik P; Hollander, Judd E; Legato, Mariane J; McGregor, Alyson J; Scott, Jane; Tewelde, Semhar; Diercks, Deborah B

2014-12-01

Coronary artery disease (CAD) is the most common cause of death for both men and women. However, over the years, emergency physicians, cardiologists, and other health care practitioners have observed varying outcomes in men and women with symptomatic CAD. Women in general are 10 to 15 years older than men when they develop CAD, but suffer worse postinfarction outcomes compared to age-matched men. This article was developed by the cardiovascular workgroup at the 2014 Academic Emergency Medicine (AEM) consensus conference to identify sex- and gender-specific gaps in the key themes and research questions related to emergency cardiac ischemia care. The workgroup had diverse stakeholder representation from emergency medicine, cardiology, critical care, nursing, emergency medical services, patients, and major policy-makers in government, academia, and patient care. We implemented the nominal group technique to identify and prioritize themes and research questions using electronic mail, monthly conference calls, in-person meetings, and Web-based surveys between June 2013 and May 2014. Through three rounds of nomination and refinement, followed by an in-person meeting on May 13, 2014, we achieved consensus on five priority themes and 30 research questions. The overarching themes were as follows: 1) the full spectrum of sex-specific risk as well as presentation of cardiac ischemia may not be captured by our standard definition of CAD and needs to incorporate other forms of ischemic heart disease (IHD); 2) diagnosis is further challenged by sex/gender differences in presentation and variable sensitivity of cardiac biomarkers, imaging, and risk scores; 3) sex-specific pathophysiology of cardiac ischemia extends beyond conventional obstructive CAD to include other causes such as microvascular dysfunction, takotsubo, and coronary artery dissection, better recognized as IHD; 4) treatment and prognosis are influenced by sex-specific variations in biology, as well as patient

Mandatory Class 1 Federal Areas Web Service

Data.gov (United States)

U.S. Environmental Protection Agency — This web service contains the following layers: Mandatory Class 1 Federal Area polygons and Mandatory Class 1 Federal Area labels in the United States. The polygon...

Use of the Semantic Web to solve some basic problems in Education: Increase flexible, distributed lifelong learning, decrease teacher's workload

NARCIS (Netherlands)

Koper, Rob

2003-01-01

Please refer to: Koper, R. (2004). Use of the Semantic Web to Solve Some Basic Problems in Education: Increase Flexible, Distributed Lifelong Learning, Decrease Teacher's Workload. Journal of Interactive Media in Education, 2004 (6). Special Issue on the Educational Semantic Web. ISSN:1365-893X [

A System to Provide Real-Time Collaborative Situational Awareness by Web Enabling a Distributed Sensor Network

Science.gov (United States)

Panangadan, Anand; Monacos, Steve; Burleigh, Scott; Joswig, Joseph; James, Mark; Chow, Edward

2012-01-01

In this paper, we describe the architecture of both the PATS and SAP systems and how these two systems interoperate with each other forming a unified capability for deploying intelligence in hostile environments with the objective of providing actionable situational awareness of individuals. The SAP system works in concert with the UICDS information sharing middleware to provide data fusion from multiple sources. UICDS can then publish the sensor data using the OGC's Web Mapping Service, Web Feature Service, and Sensor Observation Service standards. The system described in the paper is able to integrate a spatially distributed sensor system, operating without the benefit of the Web infrastructure, with a remote monitoring and control system that is equipped to take advantage of SWE.

Distributed data collection and supervision based on web sensor

Science.gov (United States)

He, Pengju; Dai, Guanzhong; Fu, Lei; Li, Xiangjun

2006-11-01

As a node in Internet/Intranet, web sensor has been promoted in recent years and wildly applied in remote manufactory, workshop measurement and control field. However, the conventional scheme can only support HTTP protocol, and the remote users supervise and control the collected data published by web in the standard browser because of the limited resource of the microprocessor in the sensor; moreover, only one node of data acquirement can be supervised and controlled in one instant therefore the requirement of centralized remote supervision, control and data process can not be satisfied in some fields. In this paper, the centralized remote supervision, control and data process by the web sensor are proposed and implemented by the principle of device driver program. The useless information of the every collected web page embedded in the sensor is filtered and the useful data is transmitted to the real-time database in the workstation, and different filter algorithms are designed for different sensors possessing independent web pages. Every sensor node has its own filter program of web, called "web data collection driver program", the collecting details are shielded, and the supervision, control and configuration software can be implemented by the call of web data collection driver program just like the use of the I/O driver program. The proposed technology can be applied in the data acquirement where relative low real-time is required.

The use of web internet technologies to distribute medical images

International Nuclear Information System (INIS)

Deller, A.L.; Cheal, D.; Field, J.

1999-01-01

Full text: In the past, internet browsers were considered ineffective for image distribution. Today we have the technology to use internet standards for picture archive and communication systems (PACS) and teleradiology effectively. Advanced wavelet compression and state-of-the-art JAVA software allows us to distribute images on normal computer hardware. The use of vendor and database neutral software and industry-standard hardware has many advantages. This standards base approach avoids the costly rapid obsolescence of proprietary PACS and is cheaper to purchase and maintain. Images can be distributed around a hospital site, as well as outside the campus, quickly and inexpensively. It also allows integration between the Hospital Information System (HIS) and the Radiology Information System (RIS). Being able to utilize standard internet technologies and computer hardware for PACS is a cost-effective alternative. A system based on this technology can be used for image distribution, archiving, teleradiology and RIS integration. This can be done without expensive specialized imaging workstations and telecommunication systems. Web distribution of images allows you to send images to multiple places concurrently. A study can be within your Medical Imaging Department, as well as in the ward and on the desktop of referring clinicians - with a report. As long as there is a computer with an internet access account, high-quality images can be at your disposal 24 h a day. The importance of medical images for patient management makes them a valuable component of the patient's medical record. Therefore, an efficient system for displaying and distributing images can improve patient management and make your workplace more effective

Web party effect: a cocktail party effect in the web environment

Directory of Open Access Journals (Sweden)

Sara Rigutti

2015-03-01

Full Text Available In goal-directed web navigation, labels compete for selection: this process often involves knowledge integration and requires selective attention to manage the dizziness of web layouts. Here we ask whether the competition for selection depends on all web navigation options or only on those options that are more likely to be useful for information seeking, and provide evidence in favor of the latter alternative. Participants in our experiment navigated a representative set of real websites of variable complexity, in order to reach an information goal located two clicks away from the starting home page. The time needed to reach the goal was accounted for by a novel measure of home page complexity based on a part of (not all web options: the number of links embedded within web navigation elements weighted by the number and type of embedding elements. Our measure fully mediated the effect of several standard complexity metrics (the overall number of links, words, images, graphical regions, the JPEG file size of home page screenshots on information seeking time and usability ratings. Furthermore, it predicted the cognitive demand of web navigation, as revealed by the duration judgment ratio (i.e., the ratio of subjective to objective duration of information search. Results demonstrate that focusing on relevant links while ignoring other web objects optimizes the deployment of attentional resources necessary to navigation. This is in line with a web party effect (i.e., a cocktail party effect in the web environment: users tune into web elements that are relevant for the achievement of their navigation goals and tune out all others.

Web party effect: a cocktail party effect in the web environment

Science.gov (United States)

Gerbino, Walter

2015-01-01

In goal-directed web navigation, labels compete for selection: this process often involves knowledge integration and requires selective attention to manage the dizziness of web layouts. Here we ask whether the competition for selection depends on all web navigation options or only on those options that are more likely to be useful for information seeking, and provide evidence in favor of the latter alternative. Participants in our experiment navigated a representative set of real websites of variable complexity, in order to reach an information goal located two clicks away from the starting home page. The time needed to reach the goal was accounted for by a novel measure of home page complexity based on a part of (not all) web options: the number of links embedded within web navigation elements weighted by the number and type of embedding elements. Our measure fully mediated the effect of several standard complexity metrics (the overall number of links, words, images, graphical regions, the JPEG file size of home page screenshots) on information seeking time and usability ratings. Furthermore, it predicted the cognitive demand of web navigation, as revealed by the duration judgment ratio (i.e., the ratio of subjective to objective duration of information search). Results demonstrate that focusing on relevant links while ignoring other web objects optimizes the deployment of attentional resources necessary to navigation. This is in line with a web party effect (i.e., a cocktail party effect in the web environment): users tune into web elements that are relevant for the achievement of their navigation goals and tune out all others. PMID:25802803

From PACS to Web-based ePR system with image distribution for enterprise-level filmless healthcare delivery.

Science.gov (United States)

Huang, H K

2011-07-01

The concept of PACS (picture archiving and communication system) was initiated in 1982 during the SPIE medical imaging conference in New Port Beach, CA. Since then PACS has been matured to become an everyday clinical tool for image archiving, communication, display, and review. This paper follows the continuous development of PACS technology including Web-based PACS, PACS and ePR (electronic patient record), enterprise PACS to ePR with image distribution (ID). The concept of large-scale Web-based enterprise PACS and ePR with image distribution is presented along with its implementation, clinical deployment, and operation. The Hong Kong Hospital Authority's (HKHA) integration of its home-grown clinical management system (CMS) with PACS and ePR with image distribution is used as a case study. The current concept and design criteria of the HKHA enterprise integration of the CMS, PACS, and ePR-ID for filmless healthcare delivery are discussed, followed by its work-in-progress and current status.

Functional alterations of human platelets following indium-111 labelling using different incubation media and labelling agents

International Nuclear Information System (INIS)

Isaka, Yoshinari; Imaizumi, Masatoshi; Kimura, Kazufumi; Matsumoto, Masayasu; Kamada, Takenobu

1991-01-01

Human platelets were labelled in the absence of presence of plasma using 111 In-labelled oxine sulphate, tropolone or 2-mercaptopyridine-N-oxide (MPO). Under in vitro and in vivo conditions, platelet functions were evaluated by measuring their aggregability, survival, recovery and early distribution. High labelling efficiency was achieved in saline labelling, whereas with plasma labelling, it was necessary to concentrate the platelet-rich plasma to 4.8x10 6 platelets/μl. The aggregation of platelets labelled in plasma or saline was compared with that of controls; platelets labelled in saline showed lower aggregability in 2 μM ADP but not in 5 μM ADP nor with collagen. No significant differences in platelet survival and recovery were noted between platelets labelled in plasma and those labelled in saline. Our results indicate that partial loss of ADP aggregability in vitro does not influence the in vivo viability of platelets labelled in saline. Scintigraphic studies showed that platelets labelled in a saline medium were temporarily sequestrated in the liver but not in the spleen or heart. Thus, platelet labelling in saline does not affect platelet function adversely, but platelets labelled in plasma are more desirable for assessing the early distribution of platelets in the reticuloendothelial system. (orig.)

A systematic review of calorie labeling and modified calorie labeling interventions: Impact on consumer and restaurant behavior

Science.gov (United States)

Bleich, Sara N.; Economos, Christina D.; Spiker, Marie L.; Vercammen, Kelsey; VanEpps, Eric M.; Block, Jason P.; Elbel, Brian; Story, Mary; Roberto, Christina A.

2017-01-01

Background Evidence on the effects of restaurant calorie labeling on consumer and restaurant behavior is mixed. This paper examined: 1) consumer responses to calorie information alone or compared to modified calorie information, and 2) changes in restaurant offerings following or in advance of menu labeling implementation. Methods We searched PubMed, Web of Science, Policy File and PAIS International to identify restaurant calorie labeling studies through October 1, 2016, that measured calories ordered, consumed, or available for purchase on restaurant menus. We also searched reference lists of calorie labeling articles. Results Fifty-three studies were included: 18 in real-world restaurants, 9 in cafeterias, and 21 in laboratory or simulation settings. Five examined restaurant offerings. Conclusion Due to a lack of well-powered studies with strong designs, the degree to which menu labeling encourages lower calorie purchases and whether that translates to a healthier population is unclear. Although there is limited evidence that menu labeling affects calories purchased at fast-food restaurants, some evidence demonstrates that it lowers calories purchased at certain types of restaurants and in cafeteria settings. The limited data on modified calorie labels find that such labels can encourage lower-calorie purchases, but may not differ in effects relative to calorie labels alone. PMID:29045080

A Systematic Review of Calorie Labeling and Modified Calorie Labeling Interventions: Impact on Consumer and Restaurant Behavior.

Science.gov (United States)

Bleich, Sara N; Economos, Christina D; Spiker, Marie L; Vercammen, Kelsey A; VanEpps, Eric M; Block, Jason P; Elbel, Brian; Story, Mary; Roberto, Christina A

2017-12-01

Evidence on the effects of restaurant calorie labeling on consumer and restaurant behavior is mixed. This paper examined: (1) consumer responses to calorie information alone or compared to modified calorie information and (2) changes in restaurant offerings following or in advance of menu labeling implementation. Searches were conducted in PubMed, Web of Science, Policy File, and PAIS International to identify restaurant calorie labeling studies through October 1, 2016, that measured calories ordered, consumed, or available for purchase on restaurant menus. The reference lists of calorie labeling articles were also searched. Fifty-three studies were included: 18 in real-world restaurants, 9 in cafeterias, and 21 in laboratory or simulation settings. Five examined restaurant offerings. Because of a lack of well-powered studies with strong designs, the degree to which menu labeling encourages lower-calorie purchases and whether that translates to a healthier population are unclear. Although there is limited evidence that menu labeling affects calories purchased at fast-food restaurants, some evidence demonstrates that it lowers calories purchased at certain types of restaurants and in cafeteria settings. The limited data on modified calorie labels find that such labels can encourage lower-calorie purchases but may not differ in effects relative to calorie labels alone. © 2017 The Obesity Society.

Metadata Schema Used in OCLC Sampled Web Pages

Directory of Open Access Journals (Sweden)

Fei Yu

2005-12-01

Full Text Available The tremendous growth of Web resources has made information organization and retrieval more and more difficult. As one approach to this problem, metadata schemas have been developed to characterize Web resources. However, many questions have been raised about the use of metadata schemas such as which metadata schemas have been used on the Web? How did they describe Web accessible information? What is the distribution of these metadata schemas among Web pages? Do certain schemas dominate the others? To address these issues, this study analyzed 16,383 Web pages with meta tags extracted from 200,000 OCLC sampled Web pages in 2000. It found that only 8.19% Web pages used meta tags; description tags, keyword tags, and Dublin Core tags were the only three schemas used in the Web pages. This article revealed the use of meta tags in terms of their function distribution, syntax characteristics, granularity of the Web pages, and the length distribution and word number distribution of both description and keywords tags.

Web interfaces to relational databases

Science.gov (United States)

Carlisle, W. H.

1996-01-01

This reports on a project to extend the capabilities of a Virtual Research Center (VRC) for NASA's Advanced Concepts Office. The work was performed as part of NASA's 1995 Summer Faculty Fellowship program and involved the development of a prototype component of the VRC - a database system that provides data creation and access services within a room of the VRC. In support of VRC development, NASA has assembled a laboratory containing the variety of equipment expected to be used by scientists within the VRC. This laboratory consists of the major hardware platforms, SUN, Intel, and Motorola processors and their most common operating systems UNIX, Windows NT, Windows for Workgroups, and Macintosh. The SPARC 20 runs SUN Solaris 2.4, an Intel Pentium runs Windows NT and is installed on a different network from the other machines in the laboratory, a Pentium PC runs Windows for Workgroups, two Intel 386 machines run Windows 3.1, and finally, a PowerMacintosh and a Macintosh IIsi run MacOS.

Tissue distributions of radiopharmaceuticals labeled with positron emitters and problems in relating them to human studies

International Nuclear Information System (INIS)

Christman, D.R.

1980-01-01

This paper discusses a few specific examples of organ distributions involving positron-emitting nuclides intended to illustrate some specific points in this area. In particular, work with 2-fluoro-2-deoxyglucose will be discussed in some detail, and its distribution in the body compared with the closely related (chemically but not biologically) 3-fluoro-3-deoxyglucose and 1- 11 C-2-deoxyglucose. Other compounds labeled with these two nuclides, and with 13 N and 15 O will also be discussed

SOMWeb: a semantic web-based system for supporting collaboration of distributed medical communities of practice.

Science.gov (United States)

Falkman, Göran; Gustafsson, Marie; Jontell, Mats; Torgersson, Olof

2008-08-26

Information technology (IT) support for remote collaboration of geographically distributed communities of practice (CoP) in health care must deal with a number of sociotechnical aspects of communication within the community. In the mid-1990s, participants of the Swedish Oral Medicine Network (SOMNet) began discussing patient cases in telephone conferences. The cases were distributed prior to the conferences using PowerPoint and email. For the technical support of online CoP, Semantic Web technologies can potentially fulfill needs of knowledge reuse, data exchange, and reasoning based on ontologies. However, more research is needed on the use of Semantic Web technologies in practice. The objectives of this research were to (1) study the communication of distributed health care professionals in oral medicine; (2) apply Semantic Web technologies to describe community data and oral medicine knowledge; (3) develop an online CoP, Swedish Oral Medicine Web (SOMWeb), centered on user-contributed case descriptions and meetings; and (4) evaluate SOMWeb and study how work practices change with IT support. Based on Java, and using the Web Ontology Language and Resource Description Framework for handling community data and oral medicine knowledge, SOMWeb was developed using a user-centered and iterative approach. For studying the work practices and evaluating the system, a mixed-method approach of interviews, observations, and a questionnaire was used. By May 2008, there were 90 registered users of SOMWeb, 93 cases had been added, and 18 meetings had utilized the system. The introduction of SOMWeb has improved the structure of meetings and their discussions, and a tenfold increase in the number of participants has been observed. Users submit cases to seek advice on diagnosis or treatment, to show an unusual case, or to create discussion. Identified barriers to submitting cases are lack of time, concern about whether the case is interesting enough, and showing gaps in one's own

SkyQuery - A Prototype Distributed Query and Cross-Matching Web Service for the Virtual Observatory

Science.gov (United States)

Thakar, A. R.; Budavari, T.; Malik, T.; Szalay, A. S.; Fekete, G.; Nieto-Santisteban, M.; Haridas, V.; Gray, J.

2002-12-01

We have developed a prototype distributed query and cross-matching service for the VO community, called SkyQuery, which is implemented with hierarchichal Web Services. SkyQuery enables astronomers to run combined queries on existing distributed heterogeneous astronomy archives. SkyQuery provides a simple, user-friendly interface to run distributed queries over the federation of registered astronomical archives in the VO. The SkyQuery client connects to the portal Web Service, which farms the query out to the individual archives, which are also Web Services called SkyNodes. The cross-matching algorithm is run recursively on each SkyNode. Each archive is a relational DBMS with a HTM index for fast spatial lookups. The results of the distributed query are returned as an XML DataSet that is automatically rendered by the client. SkyQuery also returns the image cutout corresponding to the query result. SkyQuery finds not only matches between the various catalogs, but also dropouts - objects that exist in some of the catalogs but not in others. This is often as important as finding matches. We demonstrate the utility of SkyQuery with a brown-dwarf search between SDSS and 2MASS, and a search for radio-quiet quasars in SDSS, 2MASS and FIRST. The importance of a service like SkyQuery for the worldwide astronomical community cannot be overstated: data on the same objects in various archives is mapped in different wavelength ranges and looks very different due to different errors, instrument sensitivities and other peculiarities of each archive. Our cross-matching algorithm preforms a fuzzy spatial join across multiple catalogs. This type of cross-matching is currently often done by eye, one object at a time. A static cross-identification table for a set of archives would become obsolete by the time it was built - the exponential growth of astronomical data means that a dynamic cross-identification mechanism like SkyQuery is the only viable option. SkyQuery was funded by a

Space Physics Data Facility Web Services

Science.gov (United States)

Candey, Robert M.; Harris, Bernard T.; Chimiak, Reine A.

2005-01-01

The Space Physics Data Facility (SPDF) Web services provides a distributed programming interface to a portion of the SPDF software. (A general description of Web services is available at http://www.w3.org/ and in many current software-engineering texts and articles focused on distributed programming.) The SPDF Web services distributed programming interface enables additional collaboration and integration of the SPDF software system with other software systems, in furtherance of the SPDF mission to lead collaborative efforts in the collection and utilization of space physics data and mathematical models. This programming interface conforms to all applicable Web services specifications of the World Wide Web Consortium. The interface is specified by a Web Services Description Language (WSDL) file. The SPDF Web services software consists of the following components: 1) A server program for implementation of the Web services; and 2) A software developer s kit that consists of a WSDL file, a less formal description of the interface, a Java class library (which further eases development of Java-based client software), and Java source code for an example client program that illustrates the use of the interface.

Integration of distributed plant lifecycle data using ISO 15926 and Web services

International Nuclear Information System (INIS)

Kim, Byung Chul; Teijgeler, Hans; Mun, Duhwan; Han, Soonhung

2011-01-01

Highlights: → The ISO 15926 parts that provide implementation methods are under development. → A prototype of an ISO 15926-based data repository called a facade was implemented. → The prototype facade has the advantages of data interoperability and integration. → These are obtained through the features of ISO 15926 and Web services. - Abstract: Considering the financial, safety, and environmental risks related to industrial installations, it is of paramount importance that all relevant lifecycle information is readily available. Parts of this lifecycle information are stored in a plethora of computer systems, often scattered around the world and in many native formats and languages. These parts can create a complete, holistic set of lifecycle data only when they are integrated together. At present, no software is available that can integrate these parts into one coherent, distributed, and up-to-date set. The ISO 15926 standard has been developed, and in part is still under development, to overcome this problem. In this paper, the authors discuss a prototype of an ISO 15926-based data repository called a facade, and its Web services are implemented for storing the equipment data of a nuclear power plant and servicing the data to interested organizations. This prototype is for a proof-of-concept study regarding the ISO 15926 parts that are currently under development and that are expected to provide implementation methods for the integration of distributed plant systems.

Myocardial distribution of I131-labeled hexadecenoic acid in relation to the dog local coronary flow

International Nuclear Information System (INIS)

Riche, F.; Busquet, G.; Pilichowski, P.; Wolf, J.E.; Mathieu, J.P.; Comet, M.; Pernin, C.; Vidal, M.; Vincens, M.; Godart, J.

1981-01-01

20 anesthetized and thoracotomized dogs are studied. The local myocardial blood flow is measured with sup(99m)Tc human albumin microspheres. The intramyocardial distribution of the 16-I(131)-9-hexadecenoic acid in relation to local blood flow is studied in basal conditions (7 dogs), after experimental infarction (6 dogs) and postischemic reactive hyperhemia (7 dogs). We conclude that during basal condition, after infarction but not during reactive hyperhemia, the distribution of the labeled fatty acid reflect the local variations of blood flow [fr

Labeling of Cosmetic Products

Directory of Open Access Journals (Sweden)

Nicola Lionetti

2018-03-01

Full Text Available The labeling of cosmetic products provides a set of obligations, as reported in the Regulation 1223/2009, which came into force in Europe in July 2013. The indications reported on the label are intended to enable the clear identification of the functionality and proper use of cosmetics, ensure the protection of the consumer from the commercial aspects and, above all, from the safety point of view. Moreover, it should allow quick tracing of the product details and all info of toxicological relevance. However, the misuse of this tool often leads, on one side, to confusion among cosmetics, pharmaceuticals, medical devices, and biocides. On the other side, it gives rise to fanciful interpretations by a huge number of web users, who pretend to be able to judge the quality of a cosmetic product just by reading the ingredients list. This article points out the concrete purpose of cosmetic labels, in order to shed light on the use of certain categories of ‘controversial’ ingredients and on the real quality concepts of cosmetic products. Indeed, when properly interpreted, cosmetic labels represent a good tool for the professional investigation of adverse reactions to cosmetics.

Information Literacy and Web 2.0: Is It Just Hype?

Science.gov (United States)

Godwin, Peter

2009-01-01

Purpose: The purpose of this paper is to demonstrate that Web 2.0 provides an exciting set of tools for librarians to help their students become more information-literate. Design/methodology/approach: Recently, information overload and Web 2.0 have led librarians to adopt practices labelled as Library 2.0. Information literacy can be the key to…

Radiochemical synthesis and tissue distribution of Tc-99m-labeled 7α-substituted estradiol complexes

International Nuclear Information System (INIS)

Skaddan, Marc B.; Wuest, Frank R.; Jonson, Stephanie; Syhre, Rosemarie; Welch, Michael J.; Spies, Hartmut; Katzenellenbogen, John A.

2000-01-01

The diagnosis and staging of breast cancer could be improved by the development of radiopharmaceutical imaging agents that provide a noninvasive determination of the estrogen receptor (ER) status of tumor cells. Agents labeled with 99m Tc would be especially valuable in this regard. In attempting to achieve this goal, we synthesized four 99m Tc-labeled 7α-substituted estradiol complexes. One complex utilizes the 3+1 mixed ligand design to introduce the Tc metal, whereas the other three took advantage of the cyclopentadienyltricarbonylmetal (CpTM) design. The Tc moieties were attached to the 7α position of estradiol with a hexyl tether, a monoether tether, or a polyether tether. The corresponding rhenium compounds have binding affinities for the ER of 20-45% compared with estradiol. Radiochemical yields of the 99m Tc-labeled compounds ranged from approximately 15% for the CpT-Tc complexes to 95% for the 3+1 inorganic complex. Tissue distribution studies in immature female rats showed low nonreceptor-mediated uptake in the target organs and high uptake in nontarget organs such as the liver and fat. These complexes represent the first time that estradiol has been labeled at the 7α position with 99m Tc and provide a further refinement of our understanding of ligand structure-binding affinity correlations for the ER

Analysis of a benthic community food web using isotopically labelled potential food

International Nuclear Information System (INIS)

Beviss-Challinor, M.H.; Field, J.G.

1982-01-01

A series of experiments was designed to reveal the trophic structure of a benthic community using kelp holdfasts as microcosms within the kelp-bed community. The experimental food comprised zooplankton represented by 3 H 2 O-labelled Artemia sp. eggs and nauplii (200 to 300 μm), detritus derived from 14 C-labelled kelp (60 to 90 μm), and phytoplankton represented by 14 C-labelled Dunaliella primolecta (5 to 10 μm) cultures. Separate experiments of short duration (1 to 2 h) were used to indicate the primary consumers on each type of food, while longer experiments (4, 8 and 16 h) suggested the secondary consumers (coprophagous and carnivorous species). Several species were found to be omnivorous. (orig.)

Programming Web services with Perl

CERN Document Server

Ray, Randy J

2003-01-01

Given Perl's natural fit for web applications development, it's no surprise that Perl is also a natural choice for web services development. It's the most popular web programming language, with strong implementations of both SOAP and XML-RPC, the leading ways to distribute applications using web services. But books on web services focus on writing these applications in Java or Visual Basic, leaving Perl programmers with few resources to get them started. Programming Web Services with Perl changes that, bringing Perl users all the information they need to create web services using their favori

Failure Analysis for Composition of Web Services Represented as Labeled Transition Systems

Science.gov (United States)

Nadkarni, Dinanath; Basu, Samik; Honavar, Vasant; Lutz, Robyn

The Web service composition problem involves the creation of a choreographer that provides the interaction between a set of component services to realize a goal service. Several methods have been proposed and developed to address this problem. In this paper, we consider those scenarios where the composition process may fail due to incomplete specification of goal service requirements or due to the fact that the user is unaware of the functionality provided by the existing component services. In such cases, it is desirable to have a composition algorithm that can provide feedback to the user regarding the cause of failure in the composition process. Such feedback will help guide the user to re-formulate the goal service and iterate the composition process. We propose a failure analysis technique for composition algorithms that views Web service behavior as multiple sequences of input/output events. Our technique identifies the possible cause of composition failure and suggests possible recovery options to the user. We discuss our technique using a simple e-Library Web service in the context of the MoSCoE Web service composition framework.

The Semantic Web: opportunities and challenges for next-generation Web applications

Directory of Open Access Journals (Sweden)

2002-01-01

Full Text Available Recently there has been a growing interest in the investigation and development of the next generation web - the Semantic Web. While most of the current forms of web content are designed to be presented to humans, but are barely understandable by computers, the content of the Semantic Web is structured in a semantic way so that it is meaningful to computers as well as to humans. In this paper, we report a survey of recent research on the Semantic Web. In particular, we present the opportunities that this revolution will bring to us: web-services, agent-based distributed computing, semantics-based web search engines, and semantics-based digital libraries. We also discuss the technical and cultural challenges of realizing the Semantic Web: the development of ontologies, formal semantics of Semantic Web languages, and trust and proof models. We hope that this will shed some light on the direction of future work on this field.

Quality of web-based information on social phobia: a cross-sectional study.

Science.gov (United States)

Khazaal, Yasser; Fernandez, Sebastien; Cochand, Sophie; Reboh, Isabel; Zullino, Daniele

2008-01-01

The objective of the study is to evaluate the quality of web-based information on social phobia and to investigate particular quality indicators. Two keywords, "Social phobia" and "Social Anxiety Disorder", were entered into five popular World Wide Web search engines. Websites were assessed with a standardized proforma designed to rate sites on the basis of accountability, presentation, interactivity, readability, and content quality. "Health On the Net" (HON) quality label and DISCERN scale scores aiding people without content expertise to assess quality of written health publication were used to verify their efficiency as quality indicators. This study evaluates the quality of web-based information on social phobia. On the 200 identified links, 58 were included. On the basis of outcome measures, the overall quality of the sites turned out to be poor. DISCERN and HON label were indicators of good quality indicators. Accountability criteria were poor indicators of site quality. Although social phobia education Websites for patients are common, educational material highly varies in quality and content. There is a need for better evidence-based information about social phobia on the Web and a need to reconsider the role of accountability criteria as indicators of site quality. Clinicians should advise patients of the HON label and DISCERN as useful indicators of site quality. (c) 2007 Wiley-Liss, Inc.

Myocardial distribution of I/sup 131/-labeled hexadecenoic acid in relation to the dog local coronary flow

Energy Technology Data Exchange (ETDEWEB)

Riche, F.; Busquet, G.; Pilichowski, P.; Wolf, J.E.; Mathieu, J.P.; Comet, M.; Pernin, C. (Centre Hospitalier Regional, 38 - Grenoble (France)); Vidal, M.; Vincens, M.; Godart, J. (Grenoble-1 Univ., 38 (France). Inst. des Sciences Nucleaires)

1981-01-01

20 anesthetized and thoracotomized dogs are studied. The local myocardial blood flow is measured with sup(99m)Tc human albumin microspheres. The intramyocardial distribution of the 16-I(131)-9-hexadecenoic acid in relation to local blood flow is studied in basal conditions (7 dogs), after experimental infarction (6 dogs) and postischemic reactive hyperhemia (7 dogs). We conclude that during basal condition, after infarction but not during reactive hyperhemia, the distribution of the labeled fatty acid reflect the local variations of blood flow.

Distributed Web-Scale Infrastructure For Crawling, Indexing And Search With Semantic Support

Directory of Open Access Journals (Sweden)

Stefan Dlugolinsky

2012-01-01

Full Text Available In this paper, we describe our work in progress in the scope of web-scale informationextraction and information retrieval utilizing distributed computing. Wepresent a distributed architecture built on top of the MapReduce paradigm forinformation retrieval, information processing and intelligent search supportedby spatial capabilities. Proposed architecture is focused on crawling documentsin several different formats, information extraction, lightweight semantic annotationof the extracted information, indexing of extracted information andfinally on indexing of documents based on the geo-spatial information foundin a document. We demonstrate the architecture on two use cases, where thefirst is search in job offers retrieved from the LinkedIn portal and the second issearch in BBC news feeds and discuss several problems we had to face duringthe implementation. We also discuss spatial search applications for both casesbecause both LinkedIn job offer pages and BBC news feeds contain a lot of spatialinformation to extract and process.

Central transport and distribution of labelled glutamic and aspartic acids to the cochlear nucleus in cats. An autoradiographic study

Energy Technology Data Exchange (ETDEWEB)

Kane, E S [University of Massachusetts Medical School, Worcester, MA (USA). Dept. of Anatomy

1979-01-01

Tritiated L-glutamic acid or L-aspartic acid was injected unilaterally into the cochleas of adult cats, and 4 h-7 days later the localization of label was studied by light-microscopic autoradiography in sections of the brain stem. Consistent differences in labelling after glutamate and after aspartate suggest differences in their uptake, metabolic conversion and/or transport to the cochlear nucleus by cochlear fibers. The morphological differences shown here agree with the distribution of those two amino acids in the cat cochlear nucleus as shown by microchemical analyses.

[Report on the 34th meeting of the German Clinical Immunology Workgroup, Frankfurt, 03.-04.11.2006].

Science.gov (United States)

Aries, P M; Witte, T; Lamprecht, P

2007-02-01

The annual meeting of the Clinical Immunology Workgroup focused on autoimmune vasculitides. The role of innate immunity, T- and B-cells, and innovative therapies for autoimmune vasculitides was discussed. Further topics of the meeting were the role of endothelial microparticles, ghrelin and leptin, regulatory and effector-memory T-cells in ANCA-associated vasculitides, as well as the lethal midline granuloma, intracytoplasmic cytokine-profile in Behcet's disease, autoantibodies in rheumatoid arthritis, polyarteritis nodosa with cranial manifestation, ILT6 as genetic marker in multiple sclerosis and Sjögren's syndrome, alpha-fodrin autoantibodies in multiple sclerosis, interferon-g autoantibodies in a patient with atypical mycobacteriosis, and autoreactive T-cells in murine lupus.

Bicarbonate as tracer for plant assimilated C and homogeneity of 14C and 15N distribution in ryegrass and white clover tissue by alternative labeling approaches

DEFF Research Database (Denmark)

Rasmussen, Jim; Kusliene, Gedrime; Jacobsen, Ole Stig

2013-01-01

that 15N also had a heterogeneous distribution (up to two orders of magnitude). Conclusion Bicarbonate can efficiently be used to introduce 14C or 13C into plant via the leaf-labeling method. Both 14C and 15N showed heterogeneous distribution in the plant, although the distribution of 15N was more even......Aims: Application of carbon (C) and nitrogen (N) isotopes is an essential tool to study C and N flows in plant-soil-microorganisms systems. When targeting single plants in a community the tracers need to be added via e.g., leaf-labeling or stem-feeding approaches. In this study we: (i) investigated...... if bicarbonate can be used to introduce 14C (or 13C) into white clover and ryegrass, and (ii) compared the patterns of 14C and 15N allocation in white clover and ryegrass to evaluate the homogeneity of tracer distribution after two alternative labeling approaches. Methods Perennial ryegrass and white clover were...

Energy-efficiency labels and standards: A guidebook for appliances, equipment and lighting

Energy Technology Data Exchange (ETDEWEB)

McMahon, James E.; Wiel, Stephen

2001-02-16

programs and on the design of the labels and standards themselves. In addition, it directs the reader to references and other resources likely to be useful in conducting the activities described and includes a chapter on energy policies and programs that complement appliance efficiency labels and standards. This guidebook attempts to reflect the essential framework of labeling and standards programs. It is the intent of the authors and sponsors to distribute copies of this book worldwide at no charge for the general public benefit. The guidebook is also available on the web at www.CLASPonline.org and can be downloaded to be used intact or piecemeal for whatever beneficial purposes readers may conceive.

Finding Specification Pages from the Web

Science.gov (United States)

Yoshinaga, Naoki; Torisawa, Kentaro

This paper presents a method of finding a specification page on the Web for a given object (e.g., ``Ch. d'Yquem'') and its class label (e.g., ``wine''). A specification page for an object is a Web page which gives concise attribute-value information about the object (e.g., ``county''-``Sauternes'') in well formatted structures. A simple unsupervised method using layout and symbolic decoration cues was applied to a large number of the Web pages to acquire candidate attributes for each class (e.g., ``county'' for a class ``wine''). We then filter out irrelevant words from the putative attributes through an author-aware scoring function that we called site frequency. We used the acquired attributes to select a representative specification page for a given object from the Web pages retrieved by a normal search engine. Experimental results revealed that our system greatly outperformed the normal search engine in terms of this specification retrieval.

Distribution of total nitrogen and N-15 labelled nitrogen applied to apple trees

International Nuclear Information System (INIS)

Calvache, Marcelo.

1990-01-01

The efficiency of nitrogen fertilization from one year's application was studied in apple trees. Urea enriched with 1,5% N-15 a.e. was applied to 2 years old apple trees. Two irrigation treatments were studied, Al approx. 200mm/week and A2 approx. 100 mm/week. The distribution of N in the different parts of the trees was determined after 2 months of fertilization and after the experimental trees were excavated. The recovery of labelled fertilizer N was different in the trees in both treatments (Al = 1,2% and A2 = 3,1%). However, the distribution in the tree's parts was similar: 46% in leaves, 34% in branches and 20% in roots. We also determined that sampling only 20% of leaves at the beginning and the end of the experiment it is possible to know the quantity of nitrogen from fertilizer, without the excavation trees

Optimization of labeling conditions of n-isopropyl-p-iodoamphetamine chloridate (IMP) with radioiodine. Biological distribution studies

International Nuclear Information System (INIS)

Colturato, Maria Tereza

2000-01-01

The development of this work was based on a great interest from the medical community in the utilization of N-isopropyl-p-iodoamphetamine chloridate (IMP) labeled with 123 l, for brain perfusion evaluation. The IMP was initially characterized by: Melting Point (MP), Infrared Spectrophotometry (IR), Nuclear Magnetic Resonance Spectrometry (NMR), Elemental Analysis and High Performance Liquid Chromatography (HPLC). After having chosen the ideal method (nucleophilic substitution) to label IMP with that used Cu(I) as reducing agent and ascorbic acid as catalyzing of Cu(II), studies were performed to optimize the labeling parameters of 123 l-IMP: temperature reaction, time reaction, ascorbic acid mass, pH and molar ratio, and stability of the final product. The quality control method (ascending paper chromatographic) used to determine the radiochemistry purity showed to be efficient, fast and of easily handling for routine production. Biological distribution studies were performed with laboratory animals (mice) to determine the percent administered dose in the blood, different organs and whole body after intravenous administration of the radiopharmaceutical. Toxicological evaluation and in vitro study to determine the plasmatic protein binding were also done. The data of the biological distribution in mice have shown that the product crossed the intact blood brain barrier, for a enough time to obtain brain scintigraphic image, thus, allowing a follow up of further studies after the intravenous administration of the radiopharmaceutical. The 123 l-IMP showed a blood clearance and then the principal elimination route was the urinary. The kinetic study of 123 l-IMP, submitting blood samples data to BIEXP.BAS program, showed a biexponential pattern which allowed demonstrating that the compound presents a first phase of quick distribution and a second one slower corresponding to the equilibrium and elimination. Based on the results from radiochemical purity, stability and

Assessing of distribution, mobility and bioavailability of exogenous Pb in agricultural soils using isotopic labeling method coupled with BCR approach

International Nuclear Information System (INIS)

Huang, Zhi-Yong; Xie, Hong; Cao, Ying-Lan; Cai, Chao; Zhang, Zhi

2014-01-01

Highlights: • Large amounts of exogenous Pb were found to distribute in reducible fractions. • Very few of exogenous Pb were found to distribute in acid-extractable fractions. • More than 60% of exogenous Pb in rhizosphere soils lost after planting. • Isotopic labeling method and SEP enable to explore Pb bioavailability in soil. -- Abstract: The contamination of Pb in agricultural soils is one of the most important ecological problems, which potentially results in serious health risk on human health through food chain. Hence, the fate of exogenous Pb contaminated in agricultural soils is needed to be deeply explored. By spiking soils with the stable enriched isotopes of 206 Pb, the contamination of exogenous Pb 2+ ions in three agricultural soils sampled from the estuary areas of Jiulong River, China was simulated in the present study, and the distribution, mobility and bioavailability of exogenous Pb in the soils were investigated using the isotopic labeling method coupled with a four-stage BCR (European Community Bureau of Reference) sequential extraction procedure. Results showed that about 60–85% of exogenous Pb was found to distribute in reducible fractions, while the exogenous Pb in acid-extractable fractions was less than 1.0%. After planting, the amounts of exogenous Pb presenting in acid-extractable, reducible and oxidizable fractions in rhizospheric soils decreased by 60–66%, in which partial exogenous Pb was assimilated by plants while most of the metal might transfer downward due to daily watering and applying fertilizer. The results show that the isotopic labeling technique coupled with sequential extraction procedures enables us to explore the distribution, mobility and bioavailability of exogenous Pb contaminated in soils, which may be useful for the further soil remediation

Assessing of distribution, mobility and bioavailability of exogenous Pb in agricultural soils using isotopic labeling method coupled with BCR approach

Energy Technology Data Exchange (ETDEWEB)

Huang, Zhi-Yong, E-mail: zhyhuang@jmu.edu.cn [College of Bioengineering, Jimei University, Xiamen 361021 (China); Xie, Hong [College of Bioengineering, Jimei University, Xiamen 361021 (China); Shandong Vocational Animal Science and Veterinary College, Weifang 261061 (China); Cao, Ying-Lan [College of Bioengineering, Jimei University, Xiamen 361021 (China); Cai, Chao [Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021 (China); Zhang, Zhi [College of Bioengineering, Jimei University, Xiamen 361021 (China)

2014-02-15

Highlights: • Large amounts of exogenous Pb were found to distribute in reducible fractions. • Very few of exogenous Pb were found to distribute in acid-extractable fractions. • More than 60% of exogenous Pb in rhizosphere soils lost after planting. • Isotopic labeling method and SEP enable to explore Pb bioavailability in soil. -- Abstract: The contamination of Pb in agricultural soils is one of the most important ecological problems, which potentially results in serious health risk on human health through food chain. Hence, the fate of exogenous Pb contaminated in agricultural soils is needed to be deeply explored. By spiking soils with the stable enriched isotopes of {sup 206}Pb, the contamination of exogenous Pb{sup 2+} ions in three agricultural soils sampled from the estuary areas of Jiulong River, China was simulated in the present study, and the distribution, mobility and bioavailability of exogenous Pb in the soils were investigated using the isotopic labeling method coupled with a four-stage BCR (European Community Bureau of Reference) sequential extraction procedure. Results showed that about 60–85% of exogenous Pb was found to distribute in reducible fractions, while the exogenous Pb in acid-extractable fractions was less than 1.0%. After planting, the amounts of exogenous Pb presenting in acid-extractable, reducible and oxidizable fractions in rhizospheric soils decreased by 60–66%, in which partial exogenous Pb was assimilated by plants while most of the metal might transfer downward due to daily watering and applying fertilizer. The results show that the isotopic labeling technique coupled with sequential extraction procedures enables us to explore the distribution, mobility and bioavailability of exogenous Pb contaminated in soils, which may be useful for the further soil remediation.

Web service based system for generating input data sets

International Nuclear Information System (INIS)

Kralev, Velin; Kraleva, Radoslava

2011-01-01

This article deals with a three-layer architectural model of a distributed information system based on Web services, which will be used for automatic generation of sets of input data. The information system will be constructed of a client layer, a service layer and of a data layer. The web services as a tool of developing distributed software systems will be presented briefly. A web service and the implementation of its web methods will be described. A way to use the developed web methods in real application will be proposed. Keywords: web services

Coercive Tactics and Web Advertising Performance

Directory of Open Access Journals (Sweden)

Jiwon Lee

2017-07-01

Full Text Available By questioning contemporary coercive or intrusive web advertising activities, this study sheds light on the recent conditions of web advertising by focusing on a comprehensive process that leads to web ad performance. A total of 400 questionnaires were distributed by the principal investigators of this study. 170 were returned from 200 distributed questionnaires given in South Korea and 100 were returned from 200 distributed questionnaires in China. The responses total 248 out of 400 distributed questionnaires. The relationships among the measured factors are analyzed by the structural equation modeling method. Results show that the use of web ad tactics often leads to negative consequences, creating a user present avoidance behavior condition towards both the ad and ad-hosting website. In terms of the performance of the ad-hosting website, website retention was strongly influenced by content blocking. In addition, the results of the comparative test suggest that the influence of avoidance on advertising performance is stronger among users of newspaper websites than e-commerce websites.

Inter-CLI work-group: safety after Fukushima; GT inter-CLI 'surete post Fukushima'

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-11-03

This document contains a whole set of questions asked about nuclear safety and security by a work-group made of members of associations belonging to local information commissions. These questions are asked either to the French State, or to EDF, or to AREVA. They bear on general issues common to La Hague and Flamanville nuclear installations, notably public information, emergency plans, post-accident management, subcontracting, loss of electricity supply, public health, governance, computer hacking, extreme meteorological events. A set of questions concerns the AREVA processing plant in La Hague (warehousing, pools for irradiated fuels, plutonium oxide storage and warehousing, and so on), and another set concerns the Flamanville nuclear power plant (different aspects of the management of a crisis situation). The last set of questions concerns the Manche nuclear waste storage centre

Distributed nuclear medicine applications using World Wide Web and Java technology

International Nuclear Information System (INIS)

Knoll, P.; Hoell, K.; Koriska, K.; Mirzaei, S.; Koehn, H.

2000-01-01

At present, medical applications applying World Wide Web (WWW) technology are mainly used to view static images and to retrieve some information. The Java platform is a relative new way of computing, especially designed for network computing and distributed applications which enables interactive connection between user and information via the WWW. The Java 2 Software Development Kit (SDK) including Java2D API, Java Remote Method Invocation (RMI) technology, Object Serialization and the Java Advanced Imaging (JAI) extension was used to achieve a robust, platform independent and network centric solution. Medical image processing software based on this technology is presented and adequate performance capability of Java is demonstrated by an iterative reconstruction algorithm for single photon emission computerized tomography (SPECT). (orig.)

Distribution and utilization of 14C-labelled assimilate in debranched soybeans

International Nuclear Information System (INIS)

Kokubun, Makie; Asahi, Yukimitsu

1985-01-01

Effects of debranching of soybean plants on the distribution and utilization of 14 C assimilate were studied. Leaves at different positions in the canopy were allowed to assimilate 14 CO 2 either at early flowering, at early pod growth, or at early pod-filling stage. Radioactivity at 24 hours or 7 days after labelling was measured in the component parts. Debranching increased the dry weight of the main stem resulting from greater increase at the lower section of the stem. The debranched plants had the leaves of higher assimilatory efficiency and delayed senescence. The leaves at lower position of the debranched plants exported 14 C less at flowering but more at early pod growth than those of controls. When 14 C was incorporated from upper leaves, the difference in the distribution pattern between the debranched and control plants was little. A greater portion of 14 C assimilate fixed at the lower leaves of the debranched plants was present at pods and stem + petioles of the lower section, in contrast to those of controls which exported some of the assimilate to the branches. Lower leaves of the debranched plants remained active even during pod growth stage, and a part of the fixed 14 C was translocated slowly into the root. The pattern of distribution and utilization of assimilate in debranched soybeans may account for the adaptability of the main stem type to higher planting density. (author)

DistAMo: A web-based tool to characterize DNA-motif distribution on bacterial chromosomes

Directory of Open Access Journals (Sweden)

Patrick eSobetzko

2016-03-01

Full Text Available Short DNA motifs are involved in a multitude of functions such as for example chromosome segregation, DNA replication or mismatch repair. Distribution of such motifs is often not random and the specific chromosomal pattern relates to the respective motif function. Computational approaches which quantitatively assess such chromosomal motif patterns are necessary. Here we present a new computer tool DistAMo (Distribution Analysis of DNA Motifs. The algorithm uses codon redundancy to calculate the relative abundance of short DNA motifs from single genes to entire chromosomes. Comparative genomics analyses of the GATC-motif distribution in γ-proteobacterial genomes using DistAMo revealed that (i genes beside the replication origin are enriched in GATCs, (ii genome-wide GATC distribution follows a distinct pattern and (iii genes involved in DNA replication and repair are enriched in GATCs. These features are specific for bacterial chromosomes encoding a Dam methyltransferase. The new software is available as a stand-alone or as an easy-to-use web-based server version at http://www.computational.bio.uni-giessen.de/distamo.

Design of a Label-Free, Distributed Bragg Grating Resonator Based Dielectric Waveguide Biosensor

Directory of Open Access Journals (Sweden)

Florian Kehl

2015-01-01

Full Text Available In this work, we present a resonant, dielectric waveguide device based on distributed Bragg gratings for label-free biosensing applications. The refractive index sensitive optical transducer aims at improving the performance of planar waveguide grating sensor systems with limited Q-factor and dynamic range by combing the advantages of resonant cavities, such as a multitude of resonance peaks with high finesse, with the manageable complexity of waveguide grating couplers. The general sensor concept is introduced and supported by theoretical considerations as well as numerical simulations based on Coupled Mode Theory. In contrast to a single Bragg grating reflector, the presented Fabry-Pérot type distributed Bragg resonator exhibits an extended measurement range as well as relaxed fabrication tolerances. The resulting, relatively simple sensor structure can be fabricated with standard lithographic means and is independent of expensive light-sources and/or detectors, making an affordable but sensitive device, potentially suitable for point-of-care applications.

Views by SLC on the reports of the 7 work-groups of the National Debate on Energy Transition

International Nuclear Information System (INIS)

2013-01-01

This document discusses and sometimes criticizes how the French national debate on energy transition has been organized, and the proposals made by the seven work-groups. It outlines some good ideas, other ideas which are either false or in contradiction with the objectives of the energy policy, other fuzzy ideas, the lack of prior analyses, lessons which could be learned from the German policy, and the reference to the European policy. In the next part, the authors discuss the main points according to 'Sauvons le Climat': the promotion of de-carbonated energies, a prudent re-examination of the energy mix, and a new balance for subsidies awarded to renewable energies

The emergent discipline of health web science.

Science.gov (United States)

Luciano, Joanne S; Cumming, Grant P; Wilkinson, Mark D; Kahana, Eva

2013-08-22

The transformative power of the Internet on all aspects of daily life, including health care, has been widely recognized both in the scientific literature and in public discourse. Viewed through the various lenses of diverse academic disciplines, these transformations reveal opportunities realized, the promise of future advances, and even potential problems created by the penetration of the World Wide Web for both individuals and for society at large. Discussions about the clinical and health research implications of the widespread adoption of information technologies, including the Internet, have been subsumed under the disciplinary label of Medicine 2.0. More recently, however, multi-disciplinary research has emerged that is focused on the achievement and promise of the Web itself, as it relates to healthcare issues. In this paper, we explore and interrogate the contributions of the burgeoning field of Web Science in relation to health maintenance, health care, and health policy. From this, we introduce Health Web Science as a subdiscipline of Web Science, distinct from but overlapping with Medicine 2.0. This paper builds on the presentations and subsequent interdisciplinary dialogue that developed among Web-oriented investigators present at the 2012 Medicine 2.0 Conference in Boston, Massachusetts.

Multi-Label Learning via Random Label Selection for Protein Subcellular Multi-Locations Prediction.

Science.gov (United States)

Wang, Xiao; Li, Guo-Zheng

2013-03-12

Prediction of protein subcellular localization is an important but challenging problem, particularly when proteins may simultaneously exist at, or move between, two or more different subcellular location sites. Most of the existing protein subcellular localization methods are only used to deal with the single-location proteins. In the past few years, only a few methods have been proposed to tackle proteins with multiple locations. However, they only adopt a simple strategy, that is, transforming the multi-location proteins to multiple proteins with single location, which doesn't take correlations among different subcellular locations into account. In this paper, a novel method named RALS (multi-label learning via RAndom Label Selection), is proposed to learn from multi-location proteins in an effective and efficient way. Through five-fold cross validation test on a benchmark dataset, we demonstrate our proposed method with consideration of label correlations obviously outperforms the baseline BR method without consideration of label correlations, indicating correlations among different subcellular locations really exist and contribute to improvement of prediction performance. Experimental results on two benchmark datasets also show that our proposed methods achieve significantly higher performance than some other state-of-the-art methods in predicting subcellular multi-locations of proteins. The prediction web server is available at http://levis.tongji.edu.cn:8080/bioinfo/MLPred-Euk/ for the public usage.

Labelling of electricity

International Nuclear Information System (INIS)

Dettli, R.; Markard, J.

2001-01-01

This comprehensive report for the Swiss Federal Office of Energy (SFOE) presents a possible course of action to be taken to provide a means of declaring the sources of electrical power, as is foreseen in the draft of new Swiss electricity market legislation. The report presents the basic ideas behind the idea and defines the terms used such as labelling, certificates and declarations. Also, the legal situation in the European Union and in Switzerland is examined and a quantitative overview of electricity production and consumption is presented. Suggestions for a labelling scheme are made and some of the problems to be expected are looked at. The report also presents a series of examples of labelling schemes already implemented in other countries, such as Austria, Great Britain, Sweden and Germany. Tradable certificates and tracking systems are discussed as are initial quality labels like the Swiss 'Naturemade' label for green power. A concrete recommendation for the declaration and labelling of electricity in Switzerland is presented and various factors to be considered such as import/export, pumped storage, distribution losses, small-scale producers as well as the time-scales for introduction are discussed

Bioprocess-Engineering Education with Web Technology

NARCIS (Netherlands)

Sessink, O.

2006-01-01

Development of learning material that is distributed through and accessible via the World Wide Web. Various options from web technology are exploited to improve the quality and efficiency of learning material.

Electrical and Structural Characterization of Web Dendrite Crystals

Science.gov (United States)

Schwuttke, G. H.; Koliwad, K.; Dumas, K. A.

1985-01-01

Minority carrier lifetime distributions in silicon web dendrites are measured. Emphasis is placed on measuring areal homogeneity of lifetime, show its dependency on structural defects, and its unique change during hot processing. The internal gettering action of defect layers present in web crystals and their relation to minority carrier lifetime distributions is discussed. Minority carrier lifetime maps of web dendrites obtained before and after high temperature heat treatment are compared to similar maps obtained from 100 mm diameter Czochralski silicon wafers. Such maps indicate similar or superior areal homogeneity of minority carrier lifetime in webs.

User Interface Design in Medical Distributed Web Applications.

Science.gov (United States)

Serban, Alexandru; Crisan-Vida, Mihaela; Mada, Leonard; Stoicu-Tivadar, Lacramioara

2016-01-01

User interfaces are important to facilitate easy learning and operating with an IT application especially in the medical world. An easy to use interface has to be simple and to customize the user needs and mode of operation. The technology in the background is an important tool to accomplish this. The present work aims to creating a web interface using specific technology (HTML table design combined with CSS3) to provide an optimized responsive interface for a complex web application. In the first phase, the current icMED web medical application layout is analyzed, and its structure is designed using specific tools, on source files. In the second phase, a new graphic adaptable interface to different mobile terminals is proposed, (using HTML table design (TD) and CSS3 method) that uses no source files, just lines of code for layout design, improving the interaction in terms of speed and simplicity. For a complex medical software application a new prototype layout was designed and developed using HTML tables. The method uses a CSS code with only CSS classes applied to one or multiple HTML table elements, instead of CSS styles that can be applied to just one DIV tag at once. The technique has the advantage of a simplified CSS code, and a better adaptability to different media resolutions compared to DIV-CSS style method. The presented work is a proof that adaptive web interfaces can be developed just using and combining different types of design methods and technologies, using HTML table design, resulting in a simpler to learn and use interface, suitable for healthcare services.

Describing Geospatial Assets in the Web of Data: A Metadata Management Scenario

Directory of Open Access Journals (Sweden)

Cristiano Fugazza

2016-12-01

Full Text Available Metadata management is an essential enabling factor for geospatial assets because discovery, retrieval, and actual usage of the latter are tightly bound to the quality of these descriptions. Unfortunately, the multi-faceted landscape of metadata formats, requirements, and conventions makes it difficult to identify editing tools that can be easily tailored to the specificities of a given project, workgroup, and Community of Practice. Our solution is a template-driven metadata editing tool that can be customised to any XML-based schema. Its output is constituted by standards-compliant metadata records that also have a semantics-aware counterpart eliciting novel exploitation techniques. Moreover, external data sources can easily be plugged in to provide autocompletion functionalities on the basis of the data structures made available on the Web of Data. Beside presenting the essentials on customisation of the editor by means of two use cases, we extend the methodology to the whole life cycle of geospatial metadata. We demonstrate the novel capabilities enabled by RDF-based metadata representation with respect to traditional metadata management in the geospatial domain.

From Web accessibility to Web adaptability.

Science.gov (United States)

Kelly, Brian; Nevile, Liddy; Sloan, David; Fanou, Sotiris; Ellison, Ruth; Herrod, Lisa

2009-07-01

This article asserts that current approaches to enhance the accessibility of Web resources fail to provide a solid foundation for the development of a robust and future-proofed framework. In particular, they fail to take advantage of new technologies and technological practices. The article introduces a framework for Web adaptability, which encourages the development of Web-based services that can be resilient to the diversity of uses of such services, the target audience, available resources, technical innovations, organisational policies and relevant definitions of 'accessibility'. The article refers to a series of author-focussed approaches to accessibility through which the authors and others have struggled to find ways to promote accessibility for people with disabilities. These approaches depend upon the resource author's determination of the anticipated users' needs and their provision. Through approaches labelled as 1.0, 2.0 and 3.0, the authors have widened their focus to account for contexts and individual differences in target audiences. Now, the authors want to recognise the role of users in determining their engagement with resources (including services). To distinguish this new approach, the term 'adaptability' has been used to replace 'accessibility'; new definitions of accessibility have been adopted, and the authors have reviewed their previous work to clarify how it is relevant to the new approach. Accessibility 1.0 is here characterised as a technical approach in which authors are told how to construct resources for a broadly defined audience. This is known as universal design. Accessibility 2.0 was introduced to point to the need to account for the context in which resources would be used, to help overcome inadequacies identified in the purely technical approach. Accessibility 3.0 moved the focus on users from a homogenised universal definition to recognition of the idiosyncratic needs and preferences of individuals and to cater for them. All of

Web proxy auto discovery for the WLCG

CERN Document Server

Dykstra, D; Blumenfeld, B; De Salvo, A; Dewhurst, A; Verguilov, V

2017-01-01

All four of the LHC experiments depend on web proxies (that is, squids) at each grid site to support software distribution by the CernVM FileSystem (CVMFS). CMS and ATLAS also use web proxies for conditions data distributed through the Frontier Distributed Database caching system. ATLAS & CMS each have their own methods for their grid jobs to find out which web proxies to use for Frontier at each site, and CVMFS has a third method. Those diverse methods limit usability and flexibility, particularly for opportunistic use cases, where an experiment’s jobs are run at sites that do not primarily support that experiment. This paper describes a new Worldwide LHC Computing Grid (WLCG) system for discovering the addresses of web proxies. The system is based on an internet standard called Web Proxy Auto Discovery (WPAD). WPAD is in turn based on another standard called Proxy Auto Configuration (PAC). Both the Frontier and CVMFS clients support this standard. The input into the WLCG system comes from squids regis...

A Web Services Data Analysis Grid

Energy Technology Data Exchange (ETDEWEB)

William A Watson III; Ian Bird; Jie Chen; Bryan Hess; Andy Kowalski; Ying Chen

2002-07-01

The trend in large-scale scientific data analysis is to exploit compute, storage and other resources located at multiple sites, and to make those resources accessible to the scientist as if they were a single, coherent system. Web technologies driven by the huge and rapidly growing electronic commerce industry provide valuable components to speed the deployment of such sophisticated systems. Jefferson Lab, where several hundred terabytes of experimental data are acquired each year, is in the process of developing a web-based distributed system for data analysis and management. The essential aspects of this system are a distributed data grid (site independent access to experiment, simulation and model data) and a distributed batch system, augmented with various supervisory and management capabilities, and integrated using Java and XML-based web services.

A Web Services Data Analysis Grid

International Nuclear Information System (INIS)

William A Watson III; Ian Bird; Jie Chen; Bryan Hess; Andy Kowalski; Ying Chen

2002-01-01

The trend in large-scale scientific data analysis is to exploit compute, storage and other resources located at multiple sites, and to make those resources accessible to the scientist as if they were a single, coherent system. Web technologies driven by the huge and rapidly growing electronic commerce industry provide valuable components to speed the deployment of such sophisticated systems. Jefferson Lab, where several hundred terabytes of experimental data are acquired each year, is in the process of developing a web-based distributed system for data analysis and management. The essential aspects of this system are a distributed data grid (site independent access to experiment, simulation and model data) and a distributed batch system, augmented with various supervisory and management capabilities, and integrated using Java and XML-based web services

Web-Based Learning Support System

Science.gov (United States)

Fan, Lisa

Web-based learning support system offers many benefits over traditional learning environments and has become very popular. The Web is a powerful environment for distributing information and delivering knowledge to an increasingly wide and diverse audience. Typical Web-based learning environments, such as Web-CT, Blackboard, include course content delivery tools, quiz modules, grade reporting systems, assignment submission components, etc. They are powerful integrated learning management systems (LMS) that support a number of activities performed by teachers and students during the learning process [1]. However, students who study a course on the Internet tend to be more heterogeneously distributed than those found in a traditional classroom situation. In order to achieve optimal efficiency in a learning process, an individual learner needs his or her own personalized assistance. For a web-based open and dynamic learning environment, personalized support for learners becomes more important. This chapter demonstrates how to realize personalized learning support in dynamic and heterogeneous learning environments by utilizing Adaptive Web technologies. It focuses on course personalization in terms of contents and teaching materials that is according to each student's needs and capabilities. An example of using Rough Set to analyze student personal information to assist students with effective learning and predict student performance is presented.

Web Service Architecture for e-Learning

Directory of Open Access Journals (Sweden)

Xiaohong Qiu

2005-10-01

Full Text Available Message-based Web Service architecture provides a unified approach to applications and Web Services that incorporates the flexibility of messaging and distributed components. We propose SMMV and MMMV collaboration as the general architecture of collaboration based on a Web service model, which accommodates both instructor-led learning and participatory learning. This approach derives from our message-based Model-View-Controller (M-MVC architecture of Web applications, comprises an event-driven Publish/Subscribe scheme, and provides effective collaboration with high interactivity of rich Web content for diverse clients over heterogeneous network environments.

Network dynamics: The World Wide Web

Science.gov (United States)

Adamic, Lada Ariana

Despite its rapidly growing and dynamic nature, the Web displays a number of strong regularities which can be understood by drawing on methods of statistical physics. This thesis finds power-law distributions in website sizes, traffic, and links, and more importantly, develops a stochastic theory which explains them. Power-law link distributions are shown to lead to network characteristics which are especially suitable for scalable localized search. It is also demonstrated that the Web is a "small world": to reach one site from any other takes an average of only 4 hops, while most related sites cluster together. Additional dynamical properties of the Web graph are extracted from diffusion processes.

SPADOCK: Adaptive Pipeline Technology for Web System using WebSocket

Directory of Open Access Journals (Sweden)

Aries RICHI

2013-01-01

Full Text Available As information technology grows to the era of IoT(Internet of Things and cloud computing, the performance ofweb application and web service which acts as the informationgateway becomes an issue. Horizontal quality of serviceimprovement through system performance escalation becomesan issue pursued by engineers and scientists, giving birth toBigPipe pipeline technology which was developed by Facebook.We make SPADOCK, an adaptive pipeline system which is builtunder distributed system architecture with the utilization ofHTML5 WebSocket, then measure its performance. Parametersused for the measurement includes latency, workload, andbandwidth. The result shows that SPADOCK could reduceserving latency by 68.28% compared with the conventional web,and it is 20.63% faster than BigPipe.

The RNAsnp web server

DEFF Research Database (Denmark)

Radhakrishnan, Sabarinathan; Tafer, Hakim; Seemann, Ernst Stefan

2013-01-01

, are derived from extensive pre-computed tables of distributions of substitution effects as a function of gene length and GC content. Here, we present a web service that not only provides an interface for RNAsnp but also features a graphical output representation. In addition, the web server is connected...... to a local mirror of the UCSC genome browser database that enables the users to select the genomic sequences for analysis and visualize the results directly in the UCSC genome browser. The RNAsnp web server is freely available at: http://rth.dk/resources/rnasnp/....

Chloridrate of N-isopropyl-p-iodoamphetamine labeled with Iodine-131. Biological distribution in laboratory animals

International Nuclear Information System (INIS)

Colturato, Maria Tereza; Muramoto, Emiko; Carvalho, Olga Goncalves de

2000-01-01

The development of this work was based on a great interest from the medical class in the utilization of chloridrate of N-isopropyl-p-iodoamphetamine (IMP) labeled with 123 I, for brain perfusion evaluation. Studies were performed to optimize the labeling parameters of IMP with 131 I using nucleophilic substitution: temperature and, time reaction, ascorbic acid mass, pH and relation IMP mass/radioiodo activity, and stability of the final product. Radiochemistry purity method used showed to be efficient, quick and of easily handling for routine production. Biological distribution studies were performed in mice to determine the percent administered dose in the blood, different organs and whole body after intravenous administration of the radiopharmaceutical. The product crossed the intact blood brain barrier, allowing a follow up of further studies after the intravenous administration of the radiopharmaceutical. The principal elimination route 131 I-IMP was the urinary. Based on the results from radiochemical purity, stability and biological behavior in laboratory animals, we concluded that the studied radiopharmaceutical presents all ideal characteristics for clinical use in brain studies in nuclear medicine. (author)

Requirements of a security framework for the semantic web

CSIR Research Space (South Africa)

Mbaya, IR

2009-02-01

Full Text Available The vision of the Semantic Web is to provide the World Wide Web the ability to automate interoperate and reason about resources and services on the Web. However, the autonomous dynamic open distributed and heterogeneous nature of the Semantic Web...

Quality of web-based information on bipolar disorder.

Science.gov (United States)

Morel, Vincent; Chatton, Anne; Cochand, Sophie; Zullino, Daniele; Khazaal, Yasser

2008-10-01

To evaluate web-based information on bipolar disorder and to assess particular content quality indicators. Two keywords, "bipolar disorder" and "manic depressive illness" were entered into popular World Wide Web search engines. Websites were assessed with a standardized proforma designed to rate sites on the basis of accountability, presentation, interactivity, readability and content quality. "Health on the Net" (HON) quality label, and DISCERN scale scores were used to verify their efficiency as quality indicators. Of the 80 websites identified, 34 were included. Based on outcome measures, the content quality of the sites turned-out to be good. Content quality of web sites dealing with bipolar disorder is significantly explained by readability, accountability and interactivity as well as a global score. The overall content quality of the studied bipolar disorder websites is good.

Using Remotely Sensed Data for Climate Change Mitigation and Adaptation: A Collaborative Effort Between the Climate Change Adaptation Science Investigators Workgroup (CASI), NASA Johnson Space Center, and Jacobs Technology

Science.gov (United States)

Jagge, Amy

2016-01-01

With ever changing landscapes and environmental conditions due to human induced climate change, adaptability is imperative for the long-term success of facilities and Federal agency missions. To mitigate the effects of climate change, indicators such as above-ground biomass change must be identified to establish a comprehensive monitoring effort. Researching the varying effects of climate change on ecosystems can provide a scientific framework that will help produce informative, strategic and tactical policies for environmental adaptation. As a proactive approach to climate change mitigation, NASA tasked the Climate Change Adaptation Science Investigators Workgroup (CASI) to provide climate change expertise and data to Center facility managers and planners in order to ensure sustainability based on predictive models and current research. Generation of historical datasets that will be used in an agency-wide effort to establish strategies for climate change mitigation and adaptation at NASA facilities is part of the CASI strategy. Using time series of historical remotely sensed data is well-established means of measuring change over time. CASI investigators have acquired multispectral and hyperspectral optical and LiDAR remotely sensed datasets from NASA Earth Observation Satellites (including the International Space Station), airborne sensors, and astronaut photography using hand held digital cameras to create a historical dataset for the Johnson Space Center, as well as the Houston and Galveston area. The raster imagery within each dataset has been georectified, and the multispectral and hyperspectral imagery has been atmospherically corrected. Using ArcGIS for Server, the CASI-Regional Remote Sensing data has been published as an image service, and can be visualized through a basic web mapping application. Future work will include a customized web mapping application created using a JavaScript Application Programming Interface (API), and inclusion of the CASI data

Energy-Efficiency Labels and Standards: A Guidebook forAppliances, Equipment, and Lighting - 2nd Edition

Energy Technology Data Exchange (ETDEWEB)

Wiel, Stephen; McMahon, James E.

2005-04-28

, development, implementation, maintenance, and evaluation of the programs and on the design of the labels and standards themselves. In addition, it directs the reader to references and other resources likely to be useful in conducting the activities described and includes a chapter on energy policies and programs that complement appliance efficiency labels and standards. This guidebook attempts to reflect the essential framework of labeling and standards programs. It is the intent of the authors and sponsor to distribute copies of this book worldwide, at no charge, for the general public benefit. The guidebook is also available on the web at www.clasponline.org and may be downloaded to be used intact or piecemeal for whatever beneficial purposes readers may conceive.

The practice and perception of precautionary allergen labelling by the Australasian food manufacturing industry.

Science.gov (United States)

Zurzolo, G A; Peters, R L; Koplin, J J; de Courten, M; Mathai, M L; Tye-Din, J A; Tang, M L K; Campbell, D E; Ponsonby, A-L; Prescott, S L; Gurrin, L; Dharmage, S C; Allen, K J

2017-07-01

The precautionary allergen labelling (PAL) and Voluntary Incidental Trace Allergen Labelling (VITAL ® ) tools were designed by industry to assist consumers with selecting safe foods for consumption. However, a sizeable proportion of food products bear no label, and it is unclear whether these products are free from allergens and therefore safe to consume or have simply not undergone a risk assessment and therefore remain unlabelled for that reason. To assess the prevalence of unlabelled products that have undergone a risk assessment process and to examine the factors influencing industry's uptake of the VITAL ® process. A web-based questionnaire was distributed to Australasian food and grocery manufacturers. One hundred and thirty-seven Australasian manufacturers were contacted, and 59 questionnaires were returned (response rate: 43%). The respondents represented 454 different manufacturing sites. Manufacturers reported that 23% (95% CI 19-28) of products (n=102/434) that had been through the VITAL ® risk assessment process had no PAL statement on the label. 34% (95% CI 30-38), (n=204/600) of products that had undergone another (non-VITAL ® ) risk assessment process had no PAL statement. In examining the factors that influenced industry's uptake of the VITAL ® process, 25 manufacturers reported on factors that influenced the uptake of the VITAL ® process, 76% (CI 95% 55-91) reported that VITAL ® was an effective tool because it was based on science; 52% (CI 95% 31-72) reported that it was too time-consuming and 36% (CI 95% 18-57) identified a concern with it not being endorsed by the government. Currently, we estimate that at least 30% of products may have been through a risk assessment process and yet bear no PAL statement on the label. Permissive labelling could be incorporated onto these products if they have been assessed to be safe for consumption. © 2017 John Wiley & Sons Ltd.

[Food labeling and the prevention of overweight and obesity: a systematic review].

Science.gov (United States)

Sebastián-Ponce, Miren Itxaso; Sanz-Valero, Javier; Wanden-Berghe, Carmina

2011-11-01

This article reports on a systematic review of articles on food labeling and the prevention of obesity and overweight, in the MEDLINE, EMBASE, Web of Knowledge, Cochrane Library Plus, Food Science and Technology Abstracts, LILACS, and CINAHL databases. The DeCS/MeSH descriptors were obesity and food labeling. 207 articles were retrieved. Using inclusion and exclusion criteria, 14 articles were selected: 11 were on food labeling and its impact on final food product consumption; 2 were on fast food establishments; 1 on sensory attributes as compared to health recommendations; and 2 on follow-up of interventions. Labeling has a positive effect on final food product consumption, in contrast with fast food restaurants. Sensory attributes were more effective than recommendations on the labels. Follow-up of interventions confirmed the long-term effect of the target interventions.

Cost accounting for end-of-life care: recommendations to the field by the Cost Accounting Workgroup.

Science.gov (United States)

Seninger, Stephen; Smith, Dean G

2004-01-01

Accurate measurement of economic costs is prerequisite to progress in improving the care delivered to Americans during the last stage of life. The Robert Wood Johnson Excellence in End-of-Life Care national program assembled a Cost Accounting Workgroup to identify accurate and meaningful methods to measure palliative and end-of-life health care use and costs. Eight key issues were identified: (1) planning the cost analysis; (2) identifying the perspective for cost analysis; (3) describing the end-of-life care program; (4) identifying the appropriate comparison group; (5) defining the period of care to be studied; (6) identifying the units of health care services; (7) assigning monetary values to health care service units; and (8) calculating costs. Economic principles of cost measurement and cost measurement issues encountered by practitioners were reviewed and incorporated into a set of recommendations.

RosettaEPR: rotamer library for spin label structure and dynamics.

Directory of Open Access Journals (Sweden)

Nathan S Alexander

Full Text Available An increasingly used parameter in structural biology is the measurement of distances between spin labels bound to a protein. One limitation to these measurements is the unknown position of the spin label relative to the protein backbone. To overcome this drawback, we introduce a rotamer library of the methanethiosulfonate spin label (MTSSL into the protein modeling program Rosetta. Spin label rotamers were derived from conformations observed in crystal structures of spin labeled T4 lysozyme and previously published molecular dynamics simulations. Rosetta's ability to accurately recover spin label conformations and EPR measured distance distributions was evaluated against 19 experimentally determined MTSSL labeled structures of T4 lysozyme and the membrane protein LeuT and 73 distance distributions from T4 lysozyme and the membrane protein MsbA. For a site in the core of T4 lysozyme, the correct spin label conformation (Χ1 and Χ2 is recovered in 99.8% of trials. In surface positions 53% of the trajectories agree with crystallized conformations in Χ1 and Χ2. This level of recovery is on par with Rosetta performance for the 20 natural amino acids. In addition, Rosetta predicts the distance between two spin labels with a mean error of 4.4 Å. The width of the experimental distance distribution, which reflects the flexibility of the two spin labels, is predicted with a mean error of 1.3 Å. RosettaEPR makes full-atom spin label modeling available to a wide scientific community in conjunction with the powerful suite of modeling methods within Rosetta.

The distribution of sorbed moisture within a partially crystalline cellulosic web of fibres (paper)

International Nuclear Information System (INIS)

Garvey, C.; Parker, I.H.; Simon, G.

1999-01-01

Full text: Paper is a hydrophilic web of partially crystalline cellulosic fibres. In conditions of changing humidity it will sorb/desorb moisture. It has been found by dielectric relaxation spectroscopy and two dimensional nuclear magnetic resonance spectroscopy that the sorption of water causes the activation of long range co-operative molecular motions by lowering the glass transition temperature into normal ambient range. Water therefore acts as a plasticiser. NMR also indicates that the water is not uniformly distributed within the paper matrix. Preliminary experiments have been performed using the AUSANS instrument to investigate the distribution of sorbed water with the eventual aim of understanding how sorbed water is mixed within the paper sheet. Samples of paper with varying polymer morphology have been selectively deuterated by allowing to equilibrate with known D 2 O humidities. The results are discussed within the context of the AUSANS instrument

A web-based institutional DICOM distribution system with the integration of the Clinical Trial Processor (CTP).

Science.gov (United States)

Aryanto, K Y E; Broekema, A; Langenhuysen, R G A; Oudkerk, M; van Ooijen, P M A

2015-05-01

To develop and test a fast and easy rule-based web-environment with optional de-identification of imaging data to facilitate data distribution within a hospital environment. A web interface was built using Hypertext Preprocessor (PHP), an open source scripting language for web development, and Java with SQL Server to handle the database. The system allows for the selection of patient data and for de-identifying these when necessary. Using the services provided by the RSNA Clinical Trial Processor (CTP), the selected images were pushed to the appropriate services using a protocol based on the module created for the associated task. Five pipelines, each performing a different task, were set up in the server. In a 75 month period, more than 2,000,000 images are transferred and de-identified in a proper manner while 20,000,000 images are moved from one node to another without de-identification. While maintaining a high level of security and stability, the proposed system is easy to setup, it integrate well with our clinical and research practice and it provides a fast and accurate vendor-neutral process of transferring, de-identifying, and storing DICOM images. Its ability to run different de-identification processes in parallel pipelines is a major advantage in both clinical and research setting.

Virtual Sensor Web Architecture

Science.gov (United States)

Bose, P.; Zimdars, A.; Hurlburt, N.; Doug, S.

2006-12-01

NASA envisions the development of smart sensor webs, intelligent and integrated observation network that harness distributed sensing assets, their associated continuous and complex data sets, and predictive observation processing mechanisms for timely, collaborative hazard mitigation and enhanced science productivity and reliability. This paper presents Virtual Sensor Web Infrastructure for Collaborative Science (VSICS) Architecture for sustained coordination of (numerical and distributed) model-based processing, closed-loop resource allocation, and observation planning. VSICS's key ideas include i) rich descriptions of sensors as services based on semantic markup languages like OWL and SensorML; ii) service-oriented workflow composition and repair for simple and ensemble models; event-driven workflow execution based on event-based and distributed workflow management mechanisms; and iii) development of autonomous model interaction management capabilities providing closed-loop control of collection resources driven by competing targeted observation needs. We present results from initial work on collaborative science processing involving distributed services (COSEC framework) that is being extended to create VSICS.

111In,113In-labelled platelets. I

International Nuclear Information System (INIS)

Komarek, P.; Poledne, R.; Charvat, J.; Konopkova, M.; Komarkova, I.

1983-01-01

111 In-8-hydroxyquinoline (oxine) is used for labelling blood platelets which serves diagnostic purposes in medicine. For the preparation of the complex of radioactive indium with oxine, 111 In and sup(113m)In were used under optimal conditions. Two different preparation methods for the labelled complex are described. Both methods studied the effect of pH, the amount of chelate agents and the mode of filtration on the yields of the labelled oxine. The blood platelets labelling is influenced not only by the quality of labelled oxine but also by their number. The organ distribution in laboratory animals proved that platelets were not impaired during separation and labelling and that they were suitable for diagnostic use. (author)

EnviroAtlas - NHDPlus V2 Hydrologic Unit Boundaries Web Service - Conterminous United States

Data.gov (United States)

U.S. Environmental Protection Agency — This EnviroAtlas web service contains layers depicting hydrologic unit boundary layers and labels for the Subregion level (4-digit HUCs), Subbasin level (8-digit...

Discriminating nutritional quality of foods using the 5-Color nutrition label in the French food market: consistency with nutritional recommendations.

Science.gov (United States)

Julia, Chantal; Ducrot, Pauline; Péneau, Sandrine; Deschamps, Valérie; Méjean, Caroline; Fézeu, Léopold; Touvier, Mathilde; Hercberg, Serge; Kesse-Guyot, Emmanuelle

2015-09-28

Our objectives were to assess the performance of the 5-Colour nutrition label (5-CNL) front-of-pack nutrition label based on the Food Standards Agency nutrient profiling system to discriminate nutritional quality of foods currently on the market in France and its consistency with French nutritional recommendations. Nutritional composition of 7777 foods available on the French market collected from the web-based collaborative project Open Food Facts were retrieved. Distribution of products across the 5-CNL categories according to food groups, as arranged in supermarket shelves was assessed. Distribution of similar products from different brands in the 5-CNL categories was also assessed. Discriminating performance was considered as the number of color categories present in each food group. In the case of discrepancies between the category allocation and French nutritional recommendations, adaptations of the original score were proposed. Overall, the distribution of foodstuffs in the 5-CNL categories was consistent with French recommendations: 95.4% of 'Fruits and vegetables', 72.5% of 'Cereals and potatoes' were classified as 'Green' or 'Yellow' whereas 86.0% of 'Sugary snacks' were classified as 'Pink' or 'Red'. Adaptations to the original FSA score computation model were necessary for beverages, added fats and cheese in order to be consistent with French official nutritional recommendations. The 5-CNL label displays a high performance in discriminating nutritional quality of foods across food groups, within a food group and for similar products from different brands. Adaptations from the original model were necessary to maintain consistency with French recommendations and high performance of the system.

40 CFR 763.171 - Labeling requirements.

Science.gov (United States)

2010-07-01

... plastic, paper, metal, or other durable substances. Labels must be attached in such a manner that they... Act (15 U.S.C. 2605) as of (insert effective date of ban on distribution in commerce). Distribution of...

Process-aware web programming with Jolie

DEFF Research Database (Denmark)

Montesi, F.

2016-01-01

We extend the Jolie programming language to capture the native modelling of process-aware web information systems, i.e., web information systems based upon the execution of business processes. Our main contribution is to offer a unifying approach for the programming of distributed architectures...... on the web, which can capture web servers, stateful process execution, and the composition of services via mediation. We discuss applications of this approach through a series of examples that cover, e.g., static content serving, multiparty sessions, and the evolution of web systems. Finally, we present...... a performance evaluation that includes a comparison of Jolie-based web systems to other frameworks and a measurement of its scalability. © 2016 Elsevier B.V....

The EM autoradiographic distribution of label in tissue blocks of pallidum incorporating [3H]-Leu-enkephalin and [3H]-naloxone in vitro

International Nuclear Information System (INIS)

Csillag, A.; Hajos, F.

1985-01-01

The distribution of radioactivity in pallidal tissue blocks incubated in the presence of either a tritiated enkephalin analogue or [ 3 H]-naloxone, was examined using EM autoradiography. The quantitative evaluation was based on the principle of proportional grain counting. The results showed a preferential accumulating of silver grains over dendrites in the enkephalin-labelled tissue. Following naloxone-labelling, a slight enrichment of grains over axonal elements was found. The findings provide ultrastructural support for previous biochemical data which suggested that different types of opiate binding sites have different tissue localizations. (author)

Labeling of lectin receptors during the cell cycle.

Science.gov (United States)

Garrido, J

1976-12-01

Labeling of lectin receptors during the cell cycle. (Localizabión de receptores para lectinas durante el ciclo celular). Arch. Biol. Med. Exper. 10: 100-104, 1976. The topographic distribution of specific cell surface receptors for concanavalin A and wheat germ agglutinin was studied by ultrastructural labeling in the course of the cell cycle. C12TSV5 cells were synchronized by double thymidine block or mechanical selection (shakeoff). They were labeled by means of lectin-peroxidase techniques while in G1 S, G2 and M phases of the cycle. The results obtained were similar for both lectins employed. Interphase cells (G1 S, G2) present a stlihtly discontinous labeling pattern that is similar to the one observed on unsynchronized cells of the same line. Cells in mitosis, on the contrary, present a highly discontinous distribution of reaction product. This pattern disappears after the cells enters G1 and is not present on mitotic cells fixed in aldehyde prior to labeling.

Lung transit of /sup 111/Indium-labelled granulocytes. Relationship to labelling techniques

Energy Technology Data Exchange (ETDEWEB)

Saverymuttu, S.H.; Peters, A.M.; Danpure, H.J.; Reavy, H.J.; Osman, S.; Lavender, J.P. (Hammersmith Hospital, London, England)

1983-01-01

The early in vivo distribution of /sup 111/Indium-labelled granulocytes, recorded by dynamic imaging using a gamma camera and computer, varied according to the separation and labelling technique. Following i.v. bolus injection, 4 kinetic patterns could be identified: (A) rapid transit through the pulmonary vasculature, (B) delayed transit through the lung with clearance by about 30 min, (C) complete retention by the lung, for up to 10 min, followed by slow release over a period of 1 to 2 h, (D) delayed transit through the lung with a similar time course to (B) but with subsequent heavy liver uptake. Granulocytes labelled with /sup 111/In-tropolonate and maintained in plasma throughout the labelling procedure, whether injected as a 'pure' (separated by plasma-enriched density gradient centrifugation) or 'crude' (seprated by differential centrifugation) preparation, displayed type A kinetics, thought to most closely represent the normal behaviour of granulocytes. 'Crude' cells labelled in saline with /sup 111/In-acetylacetonate displayed type B kinetics. 'Pure' cells isolated on Percoll-saline and labelled in saline with /sup 111/In-acetylacetonate displayed type C kinetics, thought to represent granulocyte 'stimulation' and/or damage, or type D kientics, thought to represent severe damage. The importance is stressed of labelling granulocytes for kinetic studies with a technique that results in minimal alteration of cell behaviour.

WebGIS based on semantic grid model and web services

Science.gov (United States)

Zhang, WangFei; Yue, CaiRong; Gao, JianGuo

2009-10-01

As the combination point of the network technology and GIS technology, WebGIS has got the fast development in recent years. With the restriction of Web and the characteristics of GIS, traditional WebGIS has some prominent problems existing in development. For example, it can't accomplish the interoperability of heterogeneous spatial databases; it can't accomplish the data access of cross-platform. With the appearance of Web Service and Grid technology, there appeared great change in field of WebGIS. Web Service provided an interface which can give information of different site the ability of data sharing and inter communication. The goal of Grid technology was to make the internet to a large and super computer, with this computer we can efficiently implement the overall sharing of computing resources, storage resource, data resource, information resource, knowledge resources and experts resources. But to WebGIS, we only implement the physically connection of data and information and these is far from the enough. Because of the different understanding of the world, following different professional regulations, different policies and different habits, the experts in different field will get different end when they observed the same geographic phenomenon and the semantic heterogeneity produced. Since these there are large differences to the same concept in different field. If we use the WebGIS without considering of the semantic heterogeneity, we will answer the questions users proposed wrongly or we can't answer the questions users proposed. To solve this problem, this paper put forward and experienced an effective method of combing semantic grid and Web Services technology to develop WebGIS. In this paper, we studied the method to construct ontology and the method to combine Grid technology and Web Services and with the detailed analysis of computing characteristics and application model in the distribution of data, we designed the WebGIS query system driven by

An intelligent framework for dynamic web services composition in the semantic web

OpenAIRE

Thakker, D

2008-01-01

As Web services are being increasingly adopted as the distributed computing technology of choice to securely publish application services beyond the firewall, the importance of composing them to create new, value-added service, is increasing. Thus far, the most successful practical approach to Web services composition, largely endorsed by the industry falls under the static composition category where the service selection and flow management are done a priori and manually. The second approach...

A Sensor Web and Web Service-Based Approach for Active Hydrological Disaster Monitoring

Directory of Open Access Journals (Sweden)

Xi Zhai

2016-09-01

Full Text Available Rapid advancements in Earth-observing sensor systems have led to the generation of large amounts of remote sensing data that can be used for the dynamic monitoring and analysis of hydrological disasters. The management and analysis of these data could take advantage of distributed information infrastructure technologies such as Web service and Sensor Web technologies, which have shown great potential in facilitating the use of observed big data in an interoperable, flexible and on-demand way. However, it remains a challenge to achieve timely response to hydrological disaster events and to automate the geoprocessing of hydrological disaster observations. This article proposes a Sensor Web and Web service-based approach to support active hydrological disaster monitoring. This approach integrates an event-driven mechanism, Web services, and a Sensor Web and coordinates them using workflow technologies to facilitate the Web-based sharing and processing of hydrological hazard information. The design and implementation of hydrological Web services for conducting various hydrological analysis tasks on the Web using dynamically updating sensor observation data are presented. An application example is provided to demonstrate the benefits of the proposed approach over the traditional approach. The results confirm the effectiveness and practicality of the proposed approach in cases of hydrological disaster.

Web thickness determines the therapeutic effect of endoscopic keel placement on anterior glottic web.

Science.gov (United States)

Chen, Jian; Shi, Fang; Chen, Min; Yang, Yue; Cheng, Lei; Wu, Haitao

2017-10-01

This work is a retrospective analysis to investigate the critical risk factor for the therapeutic effect of endoscopic keel placement on anterior glottic web. Altogether, 36 patients with anterior glottic web undergoing endoscopic lysis and silicone keel placement were enrolled. Their voice qualities were evaluated using the voice handicap index-10 (VHI-10) questionnaire, and improved significantly 3 months after surgery (21.53 ± 3.89 vs 9.81 ± 6.68, P web recurrence during the at least 1-year follow-up. Therefore, patients were classified according to the Cohen classification or web thickness, and the recurrence rates were compared. The distribution of recurrence rates for Cohen type 1 ~ 4 were 28.6, 16.7, 33.3, and 40%, respectively. The difference was not statistically significant (P = 0.461). When classified by web thickness, only 2 of 27 (7.41%) thin type cases relapsed whereas 8 of 9 (88.9%) cases in the thick group reformed webs (P web thickness rather than the Cohen grades. Endoscopic lysis and keel placement is only effective for cases with thin glottic webs. Patients with thick webs should be treated by other means.

Distribution of 15N-labeled urea injected into field-grown corn plants

International Nuclear Information System (INIS)

Zhou, X.; Madrmootoo, C.A.; Mackenzie, A.F.; Smith, D.L.

1998-01-01

Nitrogen (N) assimilate supply to developing corn (Zea mays L.) ears plays a critical role in grain dry weight accumulation. The use of stem-perfused/injected 15N labeled compounds to determine the effects of an artificial N source on the subsequent distribution of injected N and grain weight of field-grown corn plants has not been reported previously. Our objective was to assess the distribution of N added via an artificial source. Three soil N fertilizer levels (0, 180, and 270 kg N ha-1) and three N solutions (distilled water control and 15N enriched urea at 15 and 30 mM N) were arranged in a split-plot design. Three N concentrations were injected using a pressurized stem injection technique. The injection started fifteen days after silking and continued until immediately prior to plant physiological maturity. The average uptake volume was 256 mL over the 30-day injection period. The N supplied via injection represented 1.5 to 3% of the total plant N. Neither soil applied N fertilizer nor injected N altered dry matter distribution among plant tissues. As the concentration of N in the injected solutions increased, N concentrations increased in the grain and upper stalks, and % 15N atom excess in ear+1 leaves and leaves increased. The relative degree of 15N enrichment for each of the tissues measured was injected internode grain upper stalks leaves lower stalks cob husk ear + 1 leaf ear leaf. This study indicated that the exogenous N supplied via stem-injection, was incorporated into all the measured plant parts, although not uniformly. The distribution of the injected 15N was affected both by the proximity of sinks to the point of injection and the strength of the various sinks

PENGEMBANGAN PERANGKAT LUNAK SISTEM INFORMASI GEOGRAFIS BERBASIS WEB

Directory of Open Access Journals (Sweden)

Budi Santosa

2015-04-01

Full Text Available Geospatial information is currently not only can be displayed using GIS software in a stand alone but can use the Internet as a medium for distributing geospatial information. Through the internet the whole population in the world can access geospatial information and provides a medium for geographic information processing desired without being limited by location. Web-based GIS map evolved from a web and client server architecture for distributed into a unity. Internet technology provides a new form for all functions of information systems is data collection, data storage, data retrieval (retrieving, data analysis and visualization of data. In this paper, the latest technology, web-based GIS with emphasis on architecture and stage of development of web-based GIS software that starts from the needs analysis to the maintenance stage. The implementation phase of the development of web-based GIS software to produce a web-based GIS product is right with the right process as well.

Open Data, Open Specifications and Free and Open Source Software: A powerful mix to create distributed Web-based water information systems

Science.gov (United States)

Arias, Carolina; Brovelli, Maria Antonia; Moreno, Rafael

2015-04-01

We are in an age when water resources are increasingly scarce and the impacts of human activities on them are ubiquitous. These problems don't respect administrative or political boundaries and they must be addressed integrating information from multiple sources at multiple spatial and temporal scales. Communication, coordination and data sharing are critical for addressing the water conservation and management issues of the 21st century. However, different countries, provinces, local authorities and agencies dealing with water resources have diverse organizational, socio-cultural, economic, environmental and information technology (IT) contexts that raise challenges to the creation of information systems capable of integrating and distributing information across their areas of responsibility in an efficient and timely manner. Tight and disparate financial resources, and dissimilar IT infrastructures (data, hardware, software and personnel expertise) further complicate the creation of these systems. There is a pressing need for distributed interoperable water information systems that are user friendly, easily accessible and capable of managing and sharing large volumes of spatial and non-spatial data. In a distributed system, data and processes are created and maintained in different locations each with competitive advantages to carry out specific activities. Open Data (data that can be freely distributed) is available in the water domain, and it should be further promoted across countries and organizations. Compliance with Open Specifications for data collection, storage and distribution is the first step toward the creation of systems that are capable of interacting and exchanging data in a seamlessly (interoperable) way. The features of Free and Open Source Software (FOSS) offer low access cost that facilitate scalability and long-term viability of information systems. The World Wide Web (the Web) will be the platform of choice to deploy and access these systems

Labeling RDF Graphs for Linear Time and Space Querying

Science.gov (United States)

Furche, Tim; Weinzierl, Antonius; Bry, François

Indices and data structures for web querying have mostly considered tree shaped data, reflecting the view of XML documents as tree-shaped. However, for RDF (and when querying ID/IDREF constraints in XML) data is indisputably graph-shaped. In this chapter, we first study existing indexing and labeling schemes for RDF and other graph datawith focus on support for efficient adjacency and reachability queries. For XML, labeling schemes are an important part of the widespread adoption of XML, in particular for mapping XML to existing (relational) database technology. However, the existing indexing and labeling schemes for RDF (and graph data in general) sacrifice one of the most attractive properties of XML labeling schemes, the constant time (and per-node space) test for adjacency (child) and reachability (descendant). In the second part, we introduce the first labeling scheme for RDF data that retains this property and thus achieves linear time and space processing of acyclic RDF queries on a significantly larger class of graphs than previous approaches (which are mostly limited to tree-shaped data). Finally, we show how this labeling scheme can be applied to (acyclic) SPARQL queries to obtain an evaluation algorithm with time and space complexity linear in the number of resources in the queried RDF graph.

Investigation on the distribution of tritium and carbon-14 in the amino acids of labelled green algae (Scenedesmus Quadricauda ssp.)

International Nuclear Information System (INIS)

Nuernberger, E.; Clausen, E.; Kistner, G.

1982-01-01

Green algae (Scenedesmus quadricauda ssp. subspicatus), labelled twice tritium and carbon-14, showed an incorporation of nuclides into the cell mass of 0.02% and 95%, respectively. The distribution of radioactivity in the individual amino acids was examined in a protein fraction with special emphasis on the essential amino acids in view of their following incorporation into the next link of the aquatic food chain (Daphnia). The highest values were found in glutamine and asparagine acids as well as in the essential amino acids leucine and arginine, which are amino acids with a relatively high amount of non exchangeable H-positions per molecule and, therefore, a relatively high and stable labelling. (author)

Smooth halos in the cosmic web

Energy Technology Data Exchange (ETDEWEB)

Gaite, José, E-mail: jose.gaite@upm.es [Physics Dept., ETSIAE, IDR, Universidad Politécnica de Madrid, Pza. Cardenal Cisneros 3, E-28040 Madrid (Spain)

2015-04-01

Dark matter halos can be defined as smooth distributions of dark matter placed in a non-smooth cosmic web structure. This definition of halos demands a precise definition of smoothness and a characterization of the manner in which the transition from smooth halos to the cosmic web takes place. We introduce entropic measures of smoothness, related to measures of inequality previously used in economy and with the advantage of being connected with standard methods of multifractal analysis already used for characterizing the cosmic web structure in cold dark matter N-body simulations. These entropic measures provide us with a quantitative description of the transition from the small scales portrayed as a distribution of halos to the larger scales portrayed as a cosmic web and, therefore, allow us to assign definite sizes to halos. However, these ''smoothness sizes'' have no direct relation to the virial radii. Finally, we discuss the influence of N-body discreteness parameters on smoothness.

Smooth halos in the cosmic web

International Nuclear Information System (INIS)

Gaite, José

2015-01-01

Dark matter halos can be defined as smooth distributions of dark matter placed in a non-smooth cosmic web structure. This definition of halos demands a precise definition of smoothness and a characterization of the manner in which the transition from smooth halos to the cosmic web takes place. We introduce entropic measures of smoothness, related to measures of inequality previously used in economy and with the advantage of being connected with standard methods of multifractal analysis already used for characterizing the cosmic web structure in cold dark matter N-body simulations. These entropic measures provide us with a quantitative description of the transition from the small scales portrayed as a distribution of halos to the larger scales portrayed as a cosmic web and, therefore, allow us to assign definite sizes to halos. However, these ''smoothness sizes'' have no direct relation to the virial radii. Finally, we discuss the influence of N-body discreteness parameters on smoothness

Improving the interactivity and functionality of Web-based radiology teaching files with the Java programming language.

Science.gov (United States)

Eng, J

1997-01-01

Java is a programming language that runs on a "virtual machine" built into World Wide Web (WWW)-browsing programs on multiple hardware platforms. Web pages were developed with Java to enable Web-browsing programs to overlay transparent graphics and text on displayed images so that the user could control the display of labels and annotations on the images, a key feature not available with standard Web pages. This feature was extended to include the presentation of normal radiologic anatomy. Java programming was also used to make Web browsers compatible with the Digital Imaging and Communications in Medicine (DICOM) file format. By enhancing the functionality of Web pages, Java technology should provide greater incentive for using a Web-based approach in the development of radiology teaching material.

Distribution pattern and migration of 131I-labelled sperma in the uterine cervix of sheep, following insemination

International Nuclear Information System (INIS)

Brueckner, G.; Kaempfer, I.

1983-01-01

Distribution pattern of ram sperma in the uterine cervix of inseminated sheep were determined using 131 I for labelling. Emphasis in these studies was laid on comparison between diluted native sperma and deep-frozen sperma. All results so far obtained suggested that the migration capacity of most of the ram sperms had been impaired by the freezing-melting process. The amount of deep-frozen sperms present in the cranial region of the uterine cervix, a few hours after insemination, was significantly below that of native sperms. The difference was equally high and significant between native and deep-frozen sperma regarding the presence of labelled sperma between caudal and cranial regions. Evidence was produced to unambiguous nest formation of inseminated sperma in the uterine cervix. These findings are followed by a discussion of the role played by the uterine cervix as a site of sperma selection and as sperma reservoir following insemination. (author)

Performance of Web-based image distribution: client-oriented measurements

International Nuclear Information System (INIS)

Bergh, B.; Pietsch, M.; Schlaefke, A.; Vogl, T.J.

2003-01-01

The aim of this study was to define a clinically suitable personal computer (PC) configuration for Web-based image distribution and to assess the influence of different hard- and software configurations on the performance. Through specially developed software the time-to-display (TTD) for various PC configurations was measured. Different processor speeds, random access memory (RAM), screen resolutions, graphic adapters, network speeds, operating systems and examination types (computed radiography, CT, MRI) were evaluated, providing more than half a million measurements. Processor speed was the most relevant factor for the TTD; doubling the speed halved the TTD. Under processor speeds of 350 MHz, TTD mostly remained above 5 s for 1 CR or 16 CT images. Here Windows NT with lossy compression were superior. Processor speeds of 350 MHz and over delivered TTD <5 s. In this case Windows 2000 and lossless compression were preferable. Screen resolutions above 1280 x 1024 pixels increased the TTD mainly for CR images. The RAM amount, network speed and graphic adapter did not have a significant influence. The minimum threshold for clinical routine is any standard off-the-shelf PC better than Pentium II 350 MHz, 128 MB RAM; hence, high-end PC hardware is not required. (orig.)

Labelling of bacteria with indium chelates

International Nuclear Information System (INIS)

Kleinert, P.; Pfister, W.; Endert, G.; Sproessig, M.

1985-01-01

The indium chelates were prepared by reaction of radioactive indiumchloride with 10 μg oxine, 15 μg tropolone and 3 mg acetylacetone, resp. The formed chelates have been incubated with 10 9 germs/ml for 5 minutes, with labelling outputs from 90 to 95%. Both gram-positive (Streptococcus, Staphylococcus) and gram-negative bacteria (Escherichia coli) can be labelled. The reproductive capacity of the bacteria was not impaired. The application of indium labelled bacteria allows to show the distribution of microorganisms within the living organism and to investigate problems of bacterial adherence. (author)

Graph Theory Approach for Studying Food Webs

Science.gov (United States)

Longjas, A.; Tejedor, A.; Foufoula-Georgiou, E.

2017-12-01

Food webs are complex networks of feeding interactions among species in ecological communities. Metrics describing food web structure have been proposed to compare and classify food webs ranging from food chain length, connectance, degree distribution, centrality measures, to the presence of motifs (distinct compartments), among others. However, formal methodologies for studying both food web topology and the dynamic processes operating on them are still lacking. Here, we utilize a quantitative framework using graph theory within which a food web is represented by a directed graph, i.e., a collection of vertices (species or trophic species defined as sets of species sharing the same predators and prey) and directed edges (predation links). This framework allows us to identify apex (environmental "source" node) to outlet (top predators) subnetworks and compute the steady-state flux (e.g., carbon, nutrients, energy etc.) in the food web. We use this framework to (1) construct vulnerability maps that quantify the relative change of flux delivery to the top predators in response to perturbations in prey species (2) identify keystone species, whose loss would precipitate further species extinction, and (3) introduce a suite of graph-theoretic metrics to quantify the topologic (imposed by food web connectivity) and dynamic (dictated by the flux partitioning and distribution) components of a food web's complexity. By projecting food webs into a 2D Topodynamic Complexity Space whose coordinates are given by Number of alternative paths (topologic) and Leakage Index (dynamic), we show that this space provides a basis for food web comparison and provide physical insights into their dynamic behavior.

WebPresent: a World Wide Web-based telepresentation tool for physicians

Science.gov (United States)

Sampath-Kumar, Srihari; Banerjea, Anindo; Moshfeghi, Mehran

1997-05-01

In this paper, we present the design architecture and the implementation status of WebPresent - a world wide web based tele-presentation tool. This tool allows a physician to use a conference server workstation and make a presentation of patient cases to a geographically distributed audience. The audience consists of other physicians collaborating on patients' health care management and physicians participating in continuing medical education. These physicians are at several locations with networks of different bandwidth and capabilities connecting them. Audiences also receive the patient case information on different computers ranging form high-end display workstations to laptops with low-resolution displays. WebPresent is a scalable networked multimedia tool which supports the presentation of hypertext, images, audio, video, and a white-board to remote physicians with hospital Intranet access. WebPresent allows the audience to receive customized information. The data received can differ in resolution and bandwidth, depending on the availability of resources such as display resolution and network bandwidth.

131/123 iodine labeled benzamides for the detection of melanomas and metastases. Synthesis, labeling, animal experiences and preliminary clinical studies

International Nuclear Information System (INIS)

Pozzi, Oscar R.; Edreira, Martin M.; Castiglia, Silvia G.; Soroa, Victoria E.

1999-01-01

Radioiodine labeled benzamides are being studied as radiopharmaceuticals for the detection of melanomas and metastases. With this purpose the synthesis and labeling of N-(2-diethylaminoethyl)-3-[ 131 I]-4-methoxybenzamide (IMBA) has been carried out. Tissue distribution of the labeled compound has been studied in C 57 mice, showing a fast renal excretion. The labeled benzamide was also injected in mice with previously induced subcutaneous melanomas and lung metastases using B 16-F0 murine melanoma cells. The tumors show a good uptake of the labeled benzamide. The melanoma/other tissues uptake ratio is suitable for scintigraphic detection. Clinical studies in patients are under way. (author)

label.switching: An R Package for Dealing with the Label Switching Problem in MCMC Outputs

Directory of Open Access Journals (Sweden)

Panagiotis Papastamoulis

2016-02-01

Full Text Available Label switching is a well-known and fundamental problem in Bayesian estimation of mixture or hidden Markov models. In case that the prior distribution of the model parameters is the same for all states, then both the likelihood and posterior distribution are invariant to permutations of the parameters. This property makes Markov chain Monte Carlo (MCMC samples simulated from the posterior distribution non-identifiable. In this paper, the label.switching package is introduced. It contains one probabilistic and seven deterministic relabeling algorithms in order to post-process a given MCMC sample, provided by the user. Each method returns a set of permutations that can be used to reorder the MCMC output. Then, any parametric function of interest can be inferred using the reordered MCMC sample. A set of user-defined permutations is also accepted, allowing the researcher to benchmark new relabeling methods against the available ones.

iLoc-Animal: a multi-label learning classifier for predicting subcellular localization of animal proteins.

Science.gov (United States)

Lin, Wei-Zhong; Fang, Jian-An; Xiao, Xuan; Chou, Kuo-Chen

2013-04-05

Predicting protein subcellular localization is a challenging problem, particularly when query proteins have multi-label features meaning that they may simultaneously exist at, or move between, two or more different subcellular location sites. Most of the existing methods can only be used to deal with the single-label proteins. Actually, multi-label proteins should not be ignored because they usually bear some special function worthy of in-depth studies. By introducing the "multi-label learning" approach, a new predictor, called iLoc-Animal, has been developed that can be used to deal with the systems containing both single- and multi-label animal (metazoan except human) proteins. Meanwhile, to measure the prediction quality of a multi-label system in a rigorous way, five indices were introduced; they are "Absolute-True", "Absolute-False" (or Hamming-Loss"), "Accuracy", "Precision", and "Recall". As a demonstration, the jackknife cross-validation was performed with iLoc-Animal on a benchmark dataset of animal proteins classified into the following 20 location sites: (1) acrosome, (2) cell membrane, (3) centriole, (4) centrosome, (5) cell cortex, (6) cytoplasm, (7) cytoskeleton, (8) endoplasmic reticulum, (9) endosome, (10) extracellular, (11) Golgi apparatus, (12) lysosome, (13) mitochondrion, (14) melanosome, (15) microsome, (16) nucleus, (17) peroxisome, (18) plasma membrane, (19) spindle, and (20) synapse, where many proteins belong to two or more locations. For such a complicated system, the outcomes achieved by iLoc-Animal for all the aforementioned five indices were quite encouraging, indicating that the predictor may become a useful tool in this area. It has not escaped our notice that the multi-label approach and the rigorous measurement metrics can also be used to investigate many other multi-label problems in molecular biology. As a user-friendly web-server, iLoc-Animal is freely accessible to the public at the web-site .

Dotriacontane-16,17-14C distribution pattern in the respiratory system of two hamster species after passive exposure to radioactive labelled smoke

International Nuclear Information System (INIS)

Kmoch, N.; Mohr, U.

1974-01-01

The quantitative and qualitative distribution of 14 C labeled dotriacontane (DOT- 14 C) determined by liquid scintillation counting and autoradiography in the respiratory system, the digestive tract, liver and kidneys of Syrian golden and European hamsters, males and females, is described after they had been exposed to radioactive labeled cigarette smoke. The different DOT- 14 C distributions are discussed in detail with special attention given to the respiratory tract, related species differences and the topographic subdivisions of apex nasi, fundus nasi, pharynx, larynx, trachea, and lungs. It is apparent that the absolute amount of activity in the respiratory tract related to body size of the Syrian golden hamster is greater than in the European hamster but that the percentual distribution exhibits a greater filtering action of the upper respiratory tract of Syrian golden hamster than of the European hamster so that a larger percentual amount of total inhaled particulate matter reaches the lungs. The European hamster might be a more useful model for the investigation of respiratory tract carcinogenesis due to the possibility of a longer life time exposure and a higher sensitivity to respiratory tract carcinogens

Research of private label development in Croatia

Directory of Open Access Journals (Sweden)

Sandra Horvat

2009-07-01

Full Text Available Private labels have been present on the market since 19th century but their intensive market growth began in the last thirty years after retailers realized what their potential could be in the fight against ever-growing competition. Their market growth has not been distributed equally thought the world so Europe became the region with the highest private label market share, which exceeds 40% on some markets. Although the private label market share in Croatia is considerably smaller, it has also increased steadily over the last decade since private labels were introduced on the market. This paper presents the findings of a research conducted for the purpose of identifying trends in private label development on the Croatian market. The research was conducted through in-depth interviews with private label managers in retail companies in Croatia, and with the managers responsible for private label production in manufacturing companies. The research identified three expected trends of private label development in Croatia and these are: an increase in private label quality, the maintenance of a price gap between private labels and manufacturers’ brands and a further increase in the private label market share.

Grid-optimized Web 3D applications on wide area network

Science.gov (United States)

Wang, Frank; Helian, Na; Meng, Lingkui; Wu, Sining; Zhang, Wen; Guo, Yike; Parker, Michael Andrew

2008-08-01

Geographical information system has come into the Web Service times now. In this paper, Web3D applications have been developed based on our developed Gridjet platform, which provides a more effective solution for massive 3D geo-dataset sharing in distributed environments. Web3D services enabling web users could access the services as 3D scenes, virtual geographical environment and so on. However, Web3D services should be shared by thousands of essential users that inherently distributed on different geography locations. Large 3D geo-datasets need to be transferred to distributed clients via conventional HTTP, NFS and FTP protocols, which often encounters long waits and frustration in distributed wide area network environments. GridJet was used as the underlying engine between the Web 3D application node and geo-data server that utilizes a wide range of technologies including the one of paralleling the remote file access, which is a WAN/Grid-optimized protocol and provides "local-like" accesses to remote 3D geo-datasets. No change in the way of using software is required since the multi-streamed GridJet protocol remains fully compatible with existing IP infrastructures. Our recent progress includes a real-world test that Web3D applications as Google Earth over the GridJet protocol beats those over the classic ones by a factor of 2-7 where the transfer distance is over 10,000 km.

Hippuran-123 I: labelling and quality control

International Nuclear Information System (INIS)

Barboza, M.F. de; Colturato, M.T.; Herrerias, R.; Muramoto, E.

1992-01-01

The o-iodo hippuric acid labelling with radioiodine is a radiopharmaceutical used with more frequently for evaluation the kidney function. Several reactive kits for labelling with 123 I are prepared. Controls of radiochemical purity and biological distribution are made. The reactive kit of hippuran is kept at 4 C during 2 years. (C.G.C.)

An ant colony optimization based feature selection for web page classification.

Science.gov (United States)

Saraç, Esra; Özel, Selma Ayşe

2014-01-01

The increased popularity of the web has caused the inclusion of huge amount of information to the web, and as a result of this explosive information growth, automated web page classification systems are needed to improve search engines' performance. Web pages have a large number of features such as HTML/XML tags, URLs, hyperlinks, and text contents that should be considered during an automated classification process. The aim of this study is to reduce the number of features to be used to improve runtime and accuracy of the classification of web pages. In this study, we used an ant colony optimization (ACO) algorithm to select the best features, and then we applied the well-known C4.5, naive Bayes, and k nearest neighbor classifiers to assign class labels to web pages. We used the WebKB and Conference datasets in our experiments, and we showed that using the ACO for feature selection improves both accuracy and runtime performance of classification. We also showed that the proposed ACO based algorithm can select better features with respect to the well-known information gain and chi square feature selection methods.

IFIS Model-Plus: A Web-Based GUI for Visualization, Comparison and Evaluation of Distributed Flood Forecasts and Hindcasts

Science.gov (United States)

Krajewski, W. F.; Della Libera Zanchetta, A.; Mantilla, R.; Demir, I.

2017-12-01

This work explores the use of hydroinformatics tools to provide an user friendly and accessible interface for executing and assessing the output of realtime flood forecasts using distributed hydrological models. The main result is the implementation of a web system that uses an Iowa Flood Information System (IFIS)-based environment for graphical displays of rainfall-runoff simulation results for both real-time and past storm events. It communicates with ASYNCH ODE solver to perform large-scale distributed hydrological modeling based on segmentation of the terrain into hillslope-link hydrologic units. The cyber-platform also allows hindcast of model performance by testing multiple model configurations and assumptions of vertical flows in the soils. The scope of the currently implemented system is the entire set of contributing watersheds for the territory of the state of Iowa. The interface provides resources for visualization of animated maps for different water-related modeled states of the environment, including flood-waves propagation with classification of flood magnitude, runoff generation, surface soil moisture and total water column in the soil. Additional tools for comparing different model configurations and performing model evaluation by comparing to observed variables at monitored sites are also available. The user friendly interface has been published to the web under the URL http://ifis.iowafloodcenter.org/ifis/sc/modelplus/.

In vivo stability and inertness of various direct labelled and chelate-tagged protein

International Nuclear Information System (INIS)

Janoki, A.; Korosi, L.; Klivenyi, G.; Spett, B.

1987-01-01

There were looking for methods giving precise information about composition and activity distribution of protein components, both in the initial samples and serum samples after intravenous administration. It was tested the applicability of electroimmunoassay, polyacrilamide gel electrophoresis and high performance liquid chromatography for the assessment of in vivo stability and labelled proteins. The model compound was human serum albumin (HSA) labelled with 99m Tc and 125 I, respectively. Bifunctional chelate labelling was done with desferrioxamine, in this case protein was labelled with 67 Ga. Biodistribution of the labelled compounds and their elimination from the blood were studied in rabbits. Experience with various labelling proteins, especially with Tc-Sn-HSA system indicate that in vivo stability of this compounds are generally low. Following intravenous injection of proteins labelled with metal isotopes, due to dilution and to the presence of considerable amount of compatitive protein in the serum, part of the label is being detached from the carrier protein. Distribution of the detached metal is different from the original distribution of the protein. This problem arises also with radiopharmaceuticals based on monoclonal antibodies. (M.E.L.) [es

Distribution of sperm-free 131I-labelled seminal plasma in the genital tract of estrous sheep, following cervical application

International Nuclear Information System (INIS)

Brueckner, G.; Kaempfer, I.; Karl-Marx-Universitaet, Leipzig

1984-01-01

In 10 fertile sheep with synchronized estrus comparative studies with 131 I-labelled sperma and sperma-free seminal plasma were performed. 2, 4, and 22 hours after cervical application and insemination resp., the distribution of sperma and seminal plasma in different parts of the genital tract was determined. Considerable amounts of seminal plasma were revealed in vagina, cervix and uterus decreasing proportionally with both the course of the genital tract and the post-application time. Only low amounts of seminal plasma could be detected in the oviducts, while sizeable amounts diffused into the peritoneum. The levels of 131 I-labelled iodine in the thyroid were low 2 hours after application but rose to constantly higher level. The reservoirs for seminal plasma and sperma could be revealed after 22 hours. There was no marked cervical barrier to seminal plasma in sheep with synchronized estrus

Probability Distributome: A Web Computational Infrastructure for Exploring the Properties, Interrelations, and Applications of Probability Distributions.

Science.gov (United States)

Dinov, Ivo D; Siegrist, Kyle; Pearl, Dennis K; Kalinin, Alexandr; Christou, Nicolas

2016-06-01

Probability distributions are useful for modeling, simulation, analysis, and inference on varieties of natural processes and physical phenomena. There are uncountably many probability distributions. However, a few dozen families of distributions are commonly defined and are frequently used in practice for problem solving, experimental applications, and theoretical studies. In this paper, we present a new computational and graphical infrastructure, the Distributome , which facilitates the discovery, exploration and application of diverse spectra of probability distributions. The extensible Distributome infrastructure provides interfaces for (human and machine) traversal, search, and navigation of all common probability distributions. It also enables distribution modeling, applications, investigation of inter-distribution relations, as well as their analytical representations and computational utilization. The entire Distributome framework is designed and implemented as an open-source, community-built, and Internet-accessible infrastructure. It is portable, extensible and compatible with HTML5 and Web2.0 standards (http://Distributome.org). We demonstrate two types of applications of the probability Distributome resources: computational research and science education. The Distributome tools may be employed to address five complementary computational modeling applications (simulation, data-analysis and inference, model-fitting, examination of the analytical, mathematical and computational properties of specific probability distributions, and exploration of the inter-distributional relations). Many high school and college science, technology, engineering and mathematics (STEM) courses may be enriched by the use of modern pedagogical approaches and technology-enhanced methods. The Distributome resources provide enhancements for blended STEM education by improving student motivation, augmenting the classical curriculum with interactive webapps, and overhauling the

A Web Services based system for the distribution of live information at the FTU fusion experiment

International Nuclear Information System (INIS)

Boncagni, L.; Centioli, C.; Lattanzio, L.; Panella, M.; Torelli, C.; Zaccarian, L.

2009-01-01

In this paper we describe LiveMonitor, an integrated system realized for the distribution of information in fusion environments. The software tool is based on a client-server approach, where the server side consists of a set of Web Services that collect data from a variety of data sources. LiveMonitor has been successfully used at FTU, replacing and enhancing part of the core of the current message broadcasting system. The tool integrates all the information needed by the control room personnel during the experiments, namely the shot sequence status coming from the FTU Control System, videos of the plasma discharge from the FTU ports cameras, and fresh data from the databases. From the hardware point of view, the new system is made of a Linux node running the Web Services, while clients running on other machines can display information on large (46 '' ) LCD monitors. The tool has been tested during FTU experiments and can be further expanded to match the needs of the control room personnel and experimental physicists.

Ingestion and transfer of microplastics in the planktonic food web

International Nuclear Information System (INIS)

Setälä, Outi; Fleming-Lehtinen, Vivi; Lehtiniemi, Maiju

2014-01-01

Experiments were carried out with different Baltic Sea zooplankton taxa to scan their potential to ingest plastics. Mysid shrimps, copepods, cladocerans, rotifers, polychaete larvae and ciliates were exposed to 10 μm fluorescent polystyrene microspheres. These experiments showed ingestion of microspheres in all taxa studied. The highest percentage of individuals with ingested spheres was found in pelagic polychaete larvae, Marenzelleria spp. Experiments with the copepod Eurytemora affinis and the mysid shrimp Neomysis integer showed egestion of microspheres within 12 h. Food web transfer experiments were done by offering zooplankton labelled with ingested microspheres to mysid shrimps. Microscopy observations of mysid intestine showed the presence of zooplankton prey and microspheres after 3 h incubation. This study shows for the first time the potential of plastic microparticle transfer via planktonic organisms from one trophic level (mesozooplankton) to a higher level (macrozooplankton). The impacts of plastic transfer and possible accumulation in the food web need further investigations. -- Highlights: • Experiments show the potential of ingestion of plastics by various zooplankton taxa. • This ingestion of plastics can be indirect via other zooplankton organisms. • There may be several alternate routes for microplastic transfer in the food webs. -- Experiments with zooplankton and microspheres showed ingestion of spheres by zpl and the transfer of ingested microspheres to higher trophic level organisms via labelled zooplankton

WebCN: A web-based computation tool for in situ-produced cosmogenic nuclides

Energy Technology Data Exchange (ETDEWEB)

Ma Xiuzeng [Department of Physics, Purdue University, West Lafayette, IN 47907 (United States)]. E-mail: hongju@purdue.edu; Li Yingkui [Department of Geography, University of Missouri-Columbia, Columbia, MO 65211 (United States); Bourgeois, Mike [Department of Physics, Purdue University, West Lafayette, IN 47907 (United States); Caffee, Marc [Department of Physics, Purdue University, West Lafayette, IN 47907 (United States); Elmore, David [Department of Physics, Purdue University, West Lafayette, IN 47907 (United States); Granger, Darryl [Department of Earth and Atmospheric Sciences, Purdue University, West Lafayette, IN 47907 (United States); Muzikar, Paul [Department of Physics, Purdue University, West Lafayette, IN 47907 (United States); Smith, Preston [Department of Physics, Purdue University, West Lafayette, IN 47907 (United States)

2007-06-15

Cosmogenic nuclide techniques are increasingly being utilized in geoscience research. For this it is critical to establish an effective, easily accessible and well defined tool for cosmogenic nuclide computations. We have been developing a web-based tool (WebCN) to calculate surface exposure ages and erosion rates based on the nuclide concentrations measured by the accelerator mass spectrometry. WebCN for {sup 10}Be and {sup 26}Al has been finished and published at http://www.physics.purdue.edu/primelab/for{sub u}sers/rockage.html. WebCN for {sup 36}Cl is under construction. WebCN is designed as a three-tier client/server model and uses the open source PostgreSQL for the database management and PHP for the interface design and calculations. On the client side, an internet browser and Microsoft Access are used as application interfaces to access the system. Open Database Connectivity is used to link PostgreSQL and Microsoft Access. WebCN accounts for both spatial and temporal distributions of the cosmic ray flux to calculate the production rates of in situ-produced cosmogenic nuclides at the Earth's surface.

Marketing mix effects on private labels brand equity

OpenAIRE

Abril, Carmen; Rodriguez-Cánovas, Belén

2017-01-01

The present study explores some marketing mix effects on private labels brand equity creation. The research aims to study the effect of some elements under retailer's direct control such as in-store communications, in-store promotions and distribution intensity as well as other general marketing mix levers such as advertising, perceived price, and monetary promotions. The results indicate that the most efficient marketing mix tools for private label brand equity creation are private labels in...

Lithuanian on-line periodicals on the World Wide Web

Directory of Open Access Journals (Sweden)

Lina Sarlauskiene

2001-01-01

Full Text Available Deals with Lithuanian full-text electronic periodicals distributed through the World Wide Web. An electronic periodical is usually defined as a regular publication on some particular topic distributed in digital form, chiefly through the Web, but also by electronic mail or digital disk. The author has surveyed 106 publications. Thirty-four are distributed only on the Web, and 72 have printed versions. The number of analysed publications is not very big, but four years of electronic publishing and the variety of periodicals enables us to establish the causes of this phenomenon, the main features of development, and some perspectives. Electronic periodicals were analysed according to their type, purpose, contents, publisher, regularity, language, starting date and place of publication, and other features.

A framework for deriving semantic web services

OpenAIRE

Bell, D; de Cesare, S; Iacovelli, N; Lycett, M; Merico, A

2007-01-01

Web service-based development represents an emerging approach for the development of distributed information systems. Web services have been mainly applied by software practitioners as a means to modularize system functionality that can be offered across a network (e.g., intranet and/or the Internet). Although web services have been predominantly developed as a technical solution for integrating software systems, there is a more business-oriented aspect that developers and enterprises nee...

Quality of web-based information on cannabis addiction.

Science.gov (United States)

Khazaal, Yasser; Chatton, Anne; Cochand, Sophie; Zullino, Daniele

2008-01-01

This study evaluated the quality of Web-based information on cannabis use and addiction and investigated particular content quality indicators. Three keywords ("cannabis addiction," "cannabis dependence," and "cannabis abuse") were entered into two popular World Wide Web search engines. Websites were assessed with a standardized proforma designed to rate sites on the basis of accountability, presentation, interactivity, readability, and content quality. "Health on the Net" (HON) quality label, and DISCERN scale scores were used to verify their efficiency as quality indicators. Of the 94 Websites identified, 57 were included. Most were commercial sites. Based on outcome measures, the overall quality of the sites turned out to be poor. A global score (the sum of accountability, interactivity, content quality and esthetic criteria) appeared as a good content quality indicator. While cannabis education Websites for patients are widespread, their global quality is poor. There is a need for better evidence-based information about cannabis use and addiction on the Web.

Web Proxy Auto Discovery for the WLCG

Science.gov (United States)

Dykstra, D.; Blomer, J.; Blumenfeld, B.; De Salvo, A.; Dewhurst, A.; Verguilov, V.

2017-10-01

All four of the LHC experiments depend on web proxies (that is, squids) at each grid site to support software distribution by the CernVM FileSystem (CVMFS). CMS and ATLAS also use web proxies for conditions data distributed through the Frontier Distributed Database caching system. ATLAS & CMS each have their own methods for their grid jobs to find out which web proxies to use for Frontier at each site, and CVMFS has a third method. Those diverse methods limit usability and flexibility, particularly for opportunistic use cases, where an experiment’s jobs are run at sites that do not primarily support that experiment. This paper describes a new Worldwide LHC Computing Grid (WLCG) system for discovering the addresses of web proxies. The system is based on an internet standard called Web Proxy Auto Discovery (WPAD). WPAD is in turn based on another standard called Proxy Auto Configuration (PAC). Both the Frontier and CVMFS clients support this standard. The input into the WLCG system comes from squids registered in the ATLAS Grid Information System (AGIS) and CMS SITECONF files, cross-checked with squids registered by sites in the Grid Configuration Database (GOCDB) and the OSG Information Management (OIM) system, and combined with some exceptions manually configured by people from ATLAS and CMS who operate WLCG Squid monitoring. WPAD servers at CERN respond to http requests from grid nodes all over the world with a PAC file that lists available web proxies, based on IP addresses matched from a database that contains the IP address ranges registered to organizations. Large grid sites are encouraged to supply their own WPAD web servers for more flexibility, to avoid being affected by short term long distance network outages, and to offload the WLCG WPAD servers at CERN. The CERN WPAD servers additionally support requests from jobs running at non-grid sites (particularly for LHC@Home) which they direct to the nearest publicly accessible web proxy servers. The responses

Autonomous Mission Operations for Sensor Webs

Science.gov (United States)

Underbrink, A.; Witt, K.; Stanley, J.; Mandl, D.

2008-12-01

We present interim results of a 2005 ROSES AIST project entitled, "Using Intelligent Agents to Form a Sensor Web for Autonomous Mission Operations", or SWAMO. The goal of the SWAMO project is to shift the control of spacecraft missions from a ground-based, centrally controlled architecture to a collaborative, distributed set of intelligent agents. The network of intelligent agents intends to reduce management requirements by utilizing model-based system prediction and autonomic model/agent collaboration. SWAMO agents are distributed throughout the Sensor Web environment, which may include multiple spacecraft, aircraft, ground systems, and ocean systems, as well as manned operations centers. The agents monitor and manage sensor platforms, Earth sensing systems, and Earth sensing models and processes. The SWAMO agents form a Sensor Web of agents via peer-to-peer coordination. Some of the intelligent agents are mobile and able to traverse between on-orbit and ground-based systems. Other agents in the network are responsible for encapsulating system models to perform prediction of future behavior of the modeled subsystems and components to which they are assigned. The software agents use semantic web technologies to enable improved information sharing among the operational entities of the Sensor Web. The semantics include ontological conceptualizations of the Sensor Web environment, plus conceptualizations of the SWAMO agents themselves. By conceptualizations of the agents, we mean knowledge of their state, operational capabilities, current operational capacities, Web Service search and discovery results, agent collaboration rules, etc. The need for ontological conceptualizations over the agents is to enable autonomous and autonomic operations of the Sensor Web. The SWAMO ontology enables automated decision making and responses to the dynamic Sensor Web environment and to end user science requests. The current ontology is compatible with Open Geospatial Consortium (OGC

MosquitoMap and the Mal-area calculator: new web tools to relate mosquito species distribution with vector borne disease.

Science.gov (United States)

Foley, Desmond H; Wilkerson, Richard C; Birney, Ian; Harrison, Stanley; Christensen, Jamie; Rueda, Leopoldo M

2010-02-18

Mosquitoes are important vectors of diseases but, in spite of various mosquito faunistic surveys globally, there is a need for a spatial online database of mosquito collection data and distribution summaries. Such a resource could provide entomologists with the results of previous mosquito surveys, and vector disease control workers, preventative medicine practitioners, and health planners with information relating mosquito distribution to vector-borne disease risk. A web application called MosquitoMap was constructed comprising mosquito collection point data stored in an ArcGIS 9.3 Server/SQL geodatabase that includes administrative area and vector species x country lookup tables. In addition to the layer containing mosquito collection points, other map layers were made available including environmental, and vector and pathogen/disease distribution layers. An application within MosquitoMap called the Mal-area calculator (MAC) was constructed to quantify the area of overlap, for any area of interest, of vector, human, and disease distribution models. Data standards for mosquito records were developed for MosquitoMap. MosquitoMap is a public domain web resource that maps and compares georeferenced mosquito collection points to other spatial information, in a geographical information system setting. The MAC quantifies the Mal-area, i.e. the area where it is theoretically possible for vector-borne disease transmission to occur, thus providing a useful decision tool where other disease information is limited. The Mal-area approach emphasizes the independent but cumulative contribution to disease risk of the vector species predicted present. MosquitoMap adds value to, and makes accessible, the results of past collecting efforts, as well as providing a template for other arthropod spatial databases.

Web resources for myrmecologists

DEFF Research Database (Denmark)

Nash, David Richard

2005-01-01

The world wide web provides many resources that are useful to the myrmecologist. Here I provide a brief introduc- tion to the types of information currently available, and to recent developments in data provision over the internet which are likely to become important resources for myrmecologists...... in the near future. I discuss the following types of web site, and give some of the most useful examples of each: taxonomy, identification and distribution; conservation; myrmecological literature; individual species sites; news and discussion; picture galleries; personal pages; portals....

Caught in the Web

Energy Technology Data Exchange (ETDEWEB)

Gillies, James

1995-06-15

The World-Wide Web may have taken the Internet by storm, but many people would be surprised to learn that it owes its existence to CERN. Around half the world's particle physicists come to CERN for their experiments, and the Web is the result of their need to share information quickly and easily on a global scale. Six years after Tim Berners-Lee's inspired idea to marry hypertext to the Internet in 1989, CERN is handing over future Web development to the World-Wide Web Consortium, run by the French National Institute for Research in Computer Science and Control, INRIA, and the Laboratory for Computer Science of the Massachusetts Institute of Technology, MIT, leaving itself free to concentrate on physics. The Laboratory marked this transition with a conference designed to give a taste of what the Web can do, whilst firmly stamping it with the label ''Made in CERN''. Over 200 European journalists and educationalists came to CERN on 8 - 9 March for the World-Wide Web Days, resulting in wide media coverage. The conference was opened by UK Science Minister David Hunt who stressed the importance of fundamental research in generating new ideas. ''Who could have guessed 10 years ago'', he said, ''that particle physics research would lead to a communication system which would allow every school to have the biggest library in the world in a single computer?''. In his introduction, the Minister also pointed out that ''CERN and other basic research laboratories help to break new technological ground and sow the seeds of what will become mainstream manufacturing in the future.'' Learning the jargon is often the hardest part of coming to grips with any new invention, so CERN put it at the top of the agenda. Jacques Altaber, who helped introduce the Internet to CERN in the early 1980s, explained that without the Internet, the Web couldn't exist. The Internet began as a US Defense Department research project in the 1970s and has grown into a global network-ofnetworks linking some

Assessing of distribution, mobility and bioavailability of exogenous Pb in agricultural soils using isotopic labeling method coupled with BCR approach.

Science.gov (United States)

Huang, Zhi-Yong; Xie, Hong; Cao, Ying-Lan; Cai, Chao; Zhang, Zhi

2014-02-15

The contamination of Pb in agricultural soils is one of the most important ecological problems, which potentially results in serious health risk on human health through food chain. Hence, the fate of exogenous Pb contaminated in agricultural soils is needed to be deeply explored. By spiking soils with the stable enriched isotopes of (206)Pb, the contamination of exogenous Pb(2+) ions in three agricultural soils sampled from the estuary areas of Jiulong River, China was simulated in the present study, and the distribution, mobility and bioavailability of exogenous Pb in the soils were investigated using the isotopic labeling method coupled with a four-stage BCR (European Community Bureau of Reference) sequential extraction procedure. Results showed that about 60-85% of exogenous Pb was found to distribute in reducible fractions, while the exogenous Pb in acid-extractable fractions was less than 1.0%. After planting, the amounts of exogenous Pb presenting in acid-extractable, reducible and oxidizable fractions in rhizospheric soils decreased by 60-66%, in which partial exogenous Pb was assimilated by plants while most of the metal might transfer downward due to daily watering and applying fertilizer. The results show that the isotopic labeling technique coupled with sequential extraction procedures enables us to explore the distribution, mobility and bioavailability of exogenous Pb contaminated in soils, which may be useful for the further soil remediation. Copyright © 2014 Elsevier B.V. All rights reserved.

The Web as an API.

Energy Technology Data Exchange (ETDEWEB)

Roman, J. H. (Jorge H.)

2001-01-01

As programmers we have worked with many Application Development Interface API development kits. They are well suited for interaction with a particular system. A vast source of information can be made accessible by using the http protocol through the web as an API. This setup has many advantages including the vast knowledge available on setting web servers and services. Also, these tools are available on most hardware and operating system combinations. In this paper I will cover the various types of systems that can be developed this way, their advantages and some drawbacks of this approach. Index Terms--Application Programmer Interface, Distributed applications, Hyper Text Transfer Protocol, Web.

WebPIE : A web-scale parallel inference engine using MapReduce

NARCIS (Netherlands)

Urbani, Jacopo; Kotoulas, Spyros; Maassen, Jason; Van Harmelen, Frank; Bal, Henri

2012-01-01

The large amount of Semantic Web data and its fast growth pose a significant computational challenge in performing efficient and scalable reasoning. On a large scale, the resources of single machines are no longer sufficient and we are required to distribute the process to improve performance. The

78 FR 35312 - Trinity Adaptive Management Working Group; Public Meeting, Teleconference and Web-Based Meeting

Science.gov (United States)

2013-06-12

..., Scientific Advisory Board phase 1 review, Ethics coordination, Update from TRRP workgroups, Update on... statements must be supplied to Elizabeth Hadley in one of the following formats: One hard copy with original...

21 CFR 1271.250 - Labeling controls.

Science.gov (United States)

2010-04-01

..., AND CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.250 Labeling controls. (a... available for distribution is accompanied by documentation of the donor eligibility determination as...

Labelling malaria-infected human erythrocytes with Tc-99m

International Nuclear Information System (INIS)

Garmelius-Larsson, B.; Pettersson, F.; Vogt, A.; Jonsson, C.

2002-01-01

Aim: Malaria is an old and a very common disease, especially in undeveloped countries. The malaria parasites infect the erythrocytes and the aim of this work was to label infected cells for future studies of their distribution and life span. Material and Method: With a commercial kit containing stannous fluoride and sodium medronate, which is used to label erythrocytes in vivo, in vitro and in vivo/vitro methods, we labelled the cells by using a modified method and a small volume, 5 - 50 microlitre, of packed cells. The cells were labelled with Tc-99m in the range of 60 - 1500 MBq. The kit was reconstituted with saline and the pH was adjusted to 7.0. The cells were incubated with 1 ml of the kitsolution in 37 0 C for 5 min. The remaining Sn-ions were reduced by adding NaOCl and then the solution was centrifuged.The supernantant was discarded and the Tc-99m was added to the precipitate and incubated 37 0 C for 20 min and then washed 3 times. This labelling procedure was performed on both infected and on non-infected cells. Results: Ten samples of cells have been labelled. The best labelling result was obtained using 7 - 20 MBq per 10 microlitre of packed cells. The labelling efficiency was, on average, 35%. Conclusion: It is possible to label both infected and non-infected cells in very small volumes. The cells were visually inspected in a microscope and were viable after labelling. Furthermore, the cell distribution was traced in vivo in an animal model by a gamma camera

Renaissance of the Web

Science.gov (United States)

McCarty, M.

2009-09-01

The renaissance of the web has driven development of many new technologies that have forever changed the way we write software. The resulting tools have been applied to both solve problems and creat new ones in a wide range of domains ranging from monitor and control user interfaces to information distribution. This discussion covers which of and how these technologies are being used in the astronomical computing community. Topics include JavaScript, Cascading Style Sheets, HTML, XML, JSON, RSS, iCalendar, Java, PHP, Python, Ruby on Rails, database technologies, and web frameworks/design patterns.

New architecture for the sensor web: the SWAP framework.

CSIR Research Space (South Africa)

Moodley, D

2006-11-01

Full Text Available Sensor Web is a revolutionary concept towards achieving a collaborative, coherent, consistent, and consolidated sensor data collection, fusion and distribution system. Sensor Webs can perform as an extensive monitoring and sensing system...

The effect of purification of Ga-68-labeled exendin on in vivo distribution

NARCIS (Netherlands)

Brom, M.; Franssen, G.M.; Joosten, L.; Gotthardt, M.; Boerman, O.C.

2016-01-01

BACKGROUND: Ga-labeled radiotracers are increasingly used for PET imaging. During the labeling procedure, formation of (68)Ga-colloid may occur. Upon i.v. injection, (68)Ga-colloid will accumulate rapidly in the liver, spleen, and bone marrow, resulting in reduced target-to-background ratios. In

Radiosynthesis of 123I-labeled hesperetin for biodistribution study of orally administered hesperetin

International Nuclear Information System (INIS)

Jongho Jeon; So-Young Ma; Dae Seong Choi; Beom-Su Jang; Jung Ae Kang; You Ree Nam; Seonhye Yoon; Sang Hyun Park; Korea University of Science and Technology, Daejeon

2015-01-01

The purpose of this study is to synthesize 123 I-labeled hesperetin and to investigate its in vivo behavior. The optimized labeling condition provided two isomers of 123 I-labeled hesperetin with high radiochemical yields and radiochemical purities. Both 123 I-labeled products were orally administered to normal ICR mice, and the initial result showed that most of 123 I activity was detected in the stomach and the intestines. A part of 123 I-labeled hesperetin was absorbed from the small intestine to bloodstream and then it was distributed in normal organs. The results in the present study provided an efficient radiolabeling method of flavonoid and quantitative organ distribution of orally administered hesperetin. (author)

Ten years for the public Web

CERN Multimedia

2003-01-01

Ten years ago, CERN issued a statement declaring that a little known piece of software called the World Wide Web was in the public domain. Nowadays, the Web is an indispensable part of modern communications. The idea for the Web goes back to March 1989 when CERN Computer scientist Tim Berners-Lee wrote a proposal for a 'Distributed Information Management System' for the high-energy physics community. The Web was originaly conceived and developed to meet the demand for information sharing between scientists working all over the world. There were many obstacles in the 1980s to the effective exchange of information. There was, for example a great variety of computer and network systems, with hardly any common features. The main purpose of the web was to allow scientists to access information from any source in a consistent and simple way. By Christmas 1990, Berners-Lee's idea had become the World Wide Web, with its first server and browser running at CERN. Through 1991, the Web spread to other particle physics ...

Assessing tether anchor labeling and usability in pickup trucks.

Science.gov (United States)

Klinich, Kathleen D; Manary, Miriam A; Malik, Laura A; Flannagan, Carol A; Jermakian, Jessica S

2018-04-03

The objective of this study was to investigate vehicle factors associated with child restraint tether use and misuse in pickup trucks and evaluate 4 labeling interventions designed to educate consumers on proper tether use. Volunteer testing was performed with 24 subjects and 4 different pickup trucks. Each subject performed 8 child restraint installations among the 4 pickups using 2 forward-facing restraints: a Britax Marathon G4.1 and an Evenflo Triumph. Vehicles were selected to represent 4 different implementations of tether anchors among pickups: plastic loop routers (Chevrolet Silverado), webbing routers (Ram), back wall anchors (Nissan Frontier), and webbing routers plus metal anchors (Toyota Tundra). Interventions included a diagram label, Quick Response (QR) Code linked to video instruction, coordinating text label, and contrasting text tag. Subjects used the child restraint tether in 93% of trials. However, tether use was completely correct in only 9% of trials. An installation was considered functional if the subject attached the tether to a tether anchor and had a tight installation (ignoring routing and head restraint position); 28% of subjects achieved a functional installation. The most common installation error was attaching the tether hook to the anchor/router directly behind the child restraint (near the top of the seatback) rather than placing the tether through the router and attaching it to the anchor in the adjacent seating position. The Nissan Frontier, with the anchor located on the back wall of the cab, had the highest rate of correct installations but also had the highest rate of attaching the tether to components other than the tether anchor (seat adjustor, child restraint storage hook, around head restraint). None of the labeling interventions had a significant effect on correct installation; not a single subject scanned the QR Code to access the video instruction. Subjects with the most successful installations spent extensive time

Living labeling techniques of mesenchymal stem cells

International Nuclear Information System (INIS)

Dong Qingyu; Chen Li

2007-01-01

Mesenchymal stem cells (MSCs) are well known for their self-renew and multi- differentiation potentiality. With the transplantation of the MSCs which can promote the regeneration and repair of the injured tissue, a new route for the treatment of dieases is hopeful to be effective. To trace the distribution, migration, proliferation and differentiation of the implanted MSCs, there need effective labeling techniques, especially living labeling techniques. (authors)

Lyophilized kits of diamino dithiol compounds for labelling with 99m-technetium. Pharmacokinetics studies and distribution compartmental models of the related complexes

International Nuclear Information System (INIS)

Araujo, Elaine Bortoleti de

1995-01-01

The present work reflects the clinical interest for labelling diamino dithiol compounds with technetium-99m. Both chosen compounds, L,L-Ethylene dicysteine (L,L-EC) and L,L-Ethylene dicysteine diethyl esther (L,L-ECD) were obtained with relative good yield and characterized by IR and NMR. The study of labelling conditions with technetium-99m showed the influence of the type and mass of reducing agent as well as the pH on the formation of complexes with desired biological characteristics. Radiochemical purity was determined by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC). Lyophilised kits of L,L-EC and L,L-ECD for labelling with 99m Tc were obtained, with stability superior to 120 days, when stored under refrigeration, enabling the kits marketing. The ideal formulation of the kits as well as the use of liquid nitrogen in the freezing process, determined the lyophilization success. Distribution biological studies of the 99m Tc complexes were performed on mice by invasive method and on bigger animals by scintigraphic evaluation. Biological distribution studies of the complex 99m Tc-L,L-EC showed fast blood clearance, with the elimination of about 90% of the administered dose after 60 minutes, almost exclusively by the urinary system. The biological distribution results were adjusted to a three compartmental distribution model, as expected for a radiopharmaceutical designed to renal dynamic studies, with tubular elimination. The complex interaction with renal tubular receptors is related with structural characteristics of the compound, more specifically with the presence and location of polar groups. In comparison with 99m Tc-L,L-EC, biological studies of the complex 99m Tc -L,L-ECD showed different distribution aspects, despite some structural similarities. The presence of ethyl groups confers to the complex neutrality and lipophilicity. It cross the intact blood brain barrier and is retained in the brain for enough period

Flow Webs: Mechanism and Architecture for the Implementation of Sensor Webs

Science.gov (United States)

Gorlick, M. M.; Peng, G. S.; Gasster, S. D.; McAtee, M. D.

2006-12-01

The sensor web is a distributed, federated infrastructure much like its predecessors, the internet and the world wide web. It will be a federation of many sensor webs, large and small, under many distinct spans of control, that loosely cooperates and share information for many purposes. Realistically, it will grow piecemeal as distinct, individual systems are developed and deployed, some expressly built for a sensor web while many others were created for other purposes. Therefore, the architecture of the sensor web is of fundamental import and architectural strictures that inhibit innovation, experimentation, sharing or scaling may prove fatal. Drawing upon the architectural lessons of the world wide web, we offer a novel system architecture, the flow web, that elevates flows, sequences of messages over a domain of interest and constrained in both time and space, to a position of primacy as a dynamic, real-time, medium of information exchange for computational services. The flow web captures; in a single, uniform architectural style; the conflicting demands of the sensor web including dynamic adaptations to changing conditions, ease of experimentation, rapid recovery from the failures of sensors and models, automated command and control, incremental development and deployment, and integration at multiple levels—in many cases, at different times. Our conception of sensor webs—dynamic amalgamations of sensor webs each constructed within a flow web infrastructure—holds substantial promise for earth science missions in general, and of weather, air quality, and disaster management in particular. Flow webs, are by philosophy, design and implementation a dynamic infrastructure that permits massive adaptation in real-time. Flows may be attached to and detached from services at will, even while information is in transit through the flow. This concept, flow mobility, permits dynamic integration of earth science products and modeling resources in response to real

History of the CERN Web Software Public Releases

CERN Document Server

Fluckiger, Francois; CERN. Geneva. IT Department

2016-01-01

This note is an extended version of the article “Licencing the Web” (http://home.web.cern.ch/topics/birthweb/licensing-web) published by CERN, Nov 2013, in the “Birth of the Web” series of articles (http://home.cern/topics/birth-web). It describes the successive steps of the public release of the CERN Web software, from public domain to open source, and explains their rationale. It provides in annexes historical documents including release announcement and texts of the licences used by CERN and MIT in public software distributions.

Engaging Communities Where They Are: New Hampshire's Coastal Adaptation Workgroup

Science.gov (United States)

Wake, C. P.; Godlewski, S.; Howard, K.; Labranche, J.; Miller, S.; Peterson, J.; Ashcraft, C.

2015-12-01

Rising seas are expected to have significant impacts on infrastructure and natural and cultural resources on New Hampshire's 18 mile open-ocean coastline and 235 miles of tidal shoreline. However, most coastal municipalities in NH lack financial and human resources to even assess vulnerability, let alone plan for climate change. This gap has been filled since 2010 by the NH Coastal Adaptation Workgroup (CAW), composed of 21 regional, state, and federal agencies, businesses, municipalities, academics, and NGOs that bring together stakeholders to discuss climate change challenges and collaboratively develop and implement effective coastal adaptation strategies. Our grassroot efforts serve to nurture existing and build new relationships, disseminate coastal watershed climate assessments, and tap into state, federal, and foundation funds for specific coastal adaptation projects. CAW has achieved collective impact in by connecting federal and state resources to communities by raising money and facilitating projects, translating climate science, educating community members, providing direct technical assistance and general capacity, and sharing success stories and lessons learned. Indicators of success include: 12 coastal communities improved their technical, financial, and human resources for climate adaptation; 80% of the 300 participants in the eleven CAW 'Water, Weather, Climate, and Community Workshops' have increased knowledge, motivation, and capacity to address climate adaptation; $3 million in grants to help communities with climate adaptation; winner of the 2015 EPA Region 1 Environmental Merit Award; and ongoing support for community-led adaptation efforts. In addition, the NH Climate Summit attracts over 100 participants each year, over 90% whom attest to the applicability of what they learn there. CAW also plays a central role in the Coastal Risks and Hazards Commission (established by the state legislature in 2013) to help communities and businesses prepare

Hemoglobin radiolabeling: in vitro and in vivo comparison of iodine labeling with iodogen and a new method for technetium labeling

International Nuclear Information System (INIS)

Bleeker, W.K.; Feitsma, R.I.J.; Pauwels, E.K.J.; Plas, J. van der; Agterberg, J.; Rigter, G.; Bakker, J.C.

1989-01-01

The present investigation compares the suitability of two radiolabeling techniques for hemoglobin. 125 I labeling of hemoglobin with Iodogen as iodinating agent caused major changes in the chromatographic behaviour and an accelerated plasma clearance of the labeled hemoglobin in rats. A recently developed two-step procedure for 99m Tc labeling gave better results. The label had only minimal influence on the chromatographic behaviour of hemoglobin. In vivo, no free label occurred in the circulation and no transfer of the label to other plasma proteins took place. The plasma clearance of 99m Tc-labeled hemoglobin in rats was slowed. However, this could be explained entirely by diminishing glomerular filtration, probably by inhibition of the dissociation of the hemoglobin molecule into dimers. The plasma clearance of hemoglobin modified by intramolecular cross-linking, which prevents dissociation of the molecule into dimers and thus excretion by the kidney, was not influenced by the label. We conclude that the 99m Tc labeling procedure is suitable for in vivo distribution studies of hemoglobin when it is taken into account that the urinary excretion is underestimated. For cross-linked hemoglobin, which is more promising as plasma expander, no such restriction exists. (author)

Investigation and Estimation of Structure of Web from Electro spun Nano fibres

International Nuclear Information System (INIS)

Malasauskiene, J.; Milasius, R.

2013-01-01

During the electro spinning process the web of nano fibres is manufactured by means of electrostatic forces between two electrodes. The diameters of nano fibres usually differ and they depend on various parameters. The different fineness of fibres influences the structure of the web and herewith the end-use properties of such kind of nano material. Analysis of nano fibres diameters distribution also shows big differences; even more, the distributions are not spread along the normal distribution. Understanding the influence of electro spinning parameters and the reason why the shapes of distributions are so sophisticated is very important. The goal of this paper is to analyse the distribution of diameter and to propose the new criterion for nano fibres diameter comparison and web of nano fibres estimation. In this paper the influence of covering time of support material on structure of PA6.6 nano fibre web has been investigated. It was estimated that this parameter does not have a significant influence on the average diameter of nano fibres, and only the structure of web has been influenced by the changes in covering time. According to the results provided the phenomena of nano fibres sticking on the support material at the time of electro spinning can be proved and explained.

Size-based predictions of food web patterns

DEFF Research Database (Denmark)

Zhang, Lai; Hartvig, Martin; Knudsen, Kim

2014-01-01

We employ size-based theoretical arguments to derive simple analytic predictions of ecological patterns and properties of natural communities: size-spectrum exponent, maximum trophic level, and susceptibility to invasive species. The predictions are brought about by assuming that an infinite number...... of species are continuously distributed on a size-trait axis. It is, however, an open question whether such predictions are valid for a food web with a finite number of species embedded in a network structure. We address this question by comparing the size-based predictions to results from dynamic food web...... simulations with varying species richness. To this end, we develop a new size- and trait-based food web model that can be simplified into an analytically solvable size-based model. We confirm existing solutions for the size distribution and derive novel predictions for maximum trophic level and invasion...

Web based remote instrumentation and control

International Nuclear Information System (INIS)

Dhekne, P.S.; Patil, Jitendra; Kulkarni, Jitendra; Babu, Prasad; Lad, U.C.; Rahurkar, A.G.; Kaura, H.K.

2001-01-01

The Web-based technology provides a very powerful communication medium for transmitting effectively multimedia information containing data generated from various sources, which may be in the form of audio, video, text, still or moving images etc. Large number of sophisticated web based software tools are available that can be used to monitor and control distributed electronic instrumentation projects. For example data can be collected online from various smart sensors/instruments such as images from CCD camera, pressure/ humidity sensor, light intensity transducer, smoke detectors etc and uploaded in real time to a central web server. This information can be processed further, to take control action in real time from any remote client, of course with due security care. The web-based technology offers greater flexibility, higher functionality, and high degree of integration providing standardization. Further easy to use standard browser based interface at the client end to monitor, view and control the desired process parameters allow you to cut down the development time and cost to a great extent. A system based on a web client-server approach has been designed and developed at Computer division, BARC and is operational since last year to monitor and control remotely various environmental parameters of distributed computer centers. In this paper we shall discuss details of this system, its current status and additional features which are currently under development. This type of system is typically very useful for Meteorology, Environmental monitoring of Nuclear stations, Radio active labs, Nuclear waste immobilization plants, Medical and Biological research labs., Security surveillance and in many such distributed situations. A brief description of various tools used for this project such as Java, CGI, Java Script, HTML, VBScript, M-JPEG, TCP/IP, UDP, RTP etc. along with their merits/demerits have also been included

N-13 labeled amino acids: biodistribution, metabolism and dosimetric considerations

International Nuclear Information System (INIS)

Rosenspire, K.C.; Gelbard, A.S.

1986-01-01

With the growing interest in metabolic imaging and with the increasing number of cyclotron/PET facilities, more studies are being performed in animal and humans using short-lived positron-emitting radionuclides. Amino acids labeled either with N-13 or C-11 are one group of compounds being used to study in vivo regional organ (i.e., brain and heart) or tumor metabolism. Of the studies previously reported using C-11 or N-13 labeled amino acids (methionine, alanine, valine, glutamate, glutamine and tryptophan), imaging was restricted mainly to the organ or tissue of interest with little information obtained about the whole-bode distribution of the label. Such data are important for studying interorgan transport of amino acids and for determining accurate dosimetric measurements after intravenous injection of labeled amino acids. The goals of the authors study were to compare the distribution of several N-13 L-amino acids and N-13 ammonia in tumor-bearing mice and to determine the metabolic fate of the label in vivo. The following amino acids were enzymatically labeled using N-13 ammonia: glutamine, glutamate, methionine, α-aminobutyric acid, valine and leucine. 30 references, 2 figures, 14 tables

Web Application to Monitor Logistics Distribution of Disaster Relief Using the CodeIgniter Framework

Science.gov (United States)

Jamil, Mohamad; Ridwan Lessy, Mohamad

2018-03-01

Disaster management is the responsibility of the central government and local governments. The principles of disaster management, among others, are quick and precise, priorities, coordination and cohesion, efficient and effective manner. Help that is needed by most societies are logistical assistance, such as the assistance covers people’s everyday needs, such as food, instant noodles, fast food, blankets, mattresses etc. Logistical assistance is needed for disaster management, especially in times of disasters. The support of logistical assistance must be timely, to the right location, target, quality, quantity, and needs. The purpose of this study is to make a web application to monitorlogistics distribution of disaster relefusing CodeIgniter framework. Through this application, the mechanisms of aid delivery will be easily controlled from and heading to the disaster site.

Web Application To Monitor Logistics Distribution of Disaster Relief Using the CodeIgniter Framework

Directory of Open Access Journals (Sweden)

Mohamad Jamil

2017-10-01

Full Text Available Disaster management is the responsibility of the central government and local governments. The principles of disaster management, among others, are quick and precise, priorities, coordination and cohesion, efficient and effective manner. Help that is needed by most societies are logistical assistance, such as the assistance covers people's everyday needs, such as food, instant noodles, fast food, blankets, mattresses etc. Logistical assistance is needed for disaster management, especially in times of disasters. The support of logistical assistance must be timely, to the right location, target, quality, quantity, and needs. The purpose of this study is to make a web application to monitorlogistics distribution of disaster relefusing CodeIgniter framework. Through this application, the mechanisms of aid delivery will be easily controlled from and heading to the disaster site

Distribution and pharmacokinetic analysis of angiostatin radioiodine labeled with high stability

International Nuclear Information System (INIS)

Song, Sung Hee; Jung, Kyung-Ho; Paik, Jin-Young; Koh, Bong-Ho; Bae, Joon-Sang; Choe, Yearn Seong; Lee, Kyung-Han; Kim, Byung-Tae

2005-01-01

Objective: Radiotracers of anticancer agents provide important information on its in vivo handling. Angiostatin (AST) is a promising anticancer drug with potent antiangiogenic effects, but reported AST radiotracers suffer from poor in vivo stability. In this study, we synthesized an AST probe radioiodinated via the Bolton-Hunter reagent ( 125 I-BH-AST) and investigated its stability and biokinetics in mice. Methods: 125 I-BH-AST and conventional direct radioiodinated 125 I-AST were evaluated for human endothelial cell binding characteristics. In vivo stability of the radiotracers was compared by biodistribution studies in normal ICR mice. Angiostatin pharmacokinetics was analyzed by serial blood sampling after intravenous injection of 125 I-BH-AST with varying AST concentrations in mice. Results: Both 125 I-AST and 125 I-BH-AST retained selective endothelial binding as demonstrated by dose-dependent inhibition by nonradiolabeled AST. 125 I-BH-AST was substantially more stable in mice than 125 I-AST, with 28- and 7-fold lower 24-h thyroid and blood activities, respectively (15.5±1.5 vs. 430.9±32.2 and 0.1±0.0 vs. 0.8±0.0 %ID/g; both P 125 I-BH-AST, we found that 24-h AST accumulation was highest in the kidneys, followed by the liver and lungs. Kinetic analysis of 125 I-BH-AST revealed AST to have linear pharmacokinetics with a T 1/2 of 5.8±2.6 h, volume of distribution (V d ) of 6.8±1.3 ml and clearance of 0.8±0.1 ml/h. Conclusion: Radioiodine-labeled AST prepared by the BH method provides a radioprobe with superior stability and improved in vivo biokinetics that is useful for distribution and pharmacokinetic studies

Web 2.0 and pharmacy education.

Science.gov (United States)

Cain, Jeff; Fox, Brent I

2009-11-12

New types of social Internet applications (often referred to as Web 2.0) are becoming increasingly popular within higher education environments. Although developed primarily for entertainment and social communication within the general population, applications such as blogs, social video sites, and virtual worlds are being adopted by higher education institutions. These newer applications differ from standard Web sites in that they involve the users in creating and distributing information, hence effectively changing how the Web is used for knowledge generation and dispersion. Although Web 2.0 applications offer exciting new ways to teach, they should not be the core of instructional planning, but rather selected only after learning objectives and instructional strategies have been identified. This paper provides an overview of prominent Web 2.0 applications, explains how they are being used within education environments, and elaborates on some of the potential opportunities and challenges that these applications present.

Geo-communication and web-based infrastructure

DEFF Research Database (Denmark)

Brodersen, Lars; Nielsen, Anders

2005-01-01

The role of geo-information and the distribution of geo-information have changed dramatically since the introduction of web-services on the Internet. In the framework of web-services maps should be seen as an index to further geo-information. Maps are no longer an aim in themselves. In this context...... web-services perform the function as index-portals on the basis of geoinformation. The introduction of web-services as index-portals based on geoinformation has changed the conditions for both content and form of geocommunication. A high number of players and interactions (as well as a very high...... number of all kinds of information and combinations of these) characterize web-services, where maps are only a part of the whole. These new conditions demand new ways of modelling the processes leading to geo-communication. One new aspect is the fact that the service providers have become a part...

Web 2.0 and Pharmacy Education

Science.gov (United States)

Fox, Brent I.

2009-01-01

New types of social Internet applications (often referred to as Web 2.0) are becoming increasingly popular within higher education environments. Although developed primarily for entertainment and social communication within the general population, applications such as blogs, social video sites, and virtual worlds are being adopted by higher education institutions. These newer applications differ from standard Web sites in that they involve the users in creating and distributing information, hence effectively changing how the Web is used for knowledge generation and dispersion. Although Web 2.0 applications offer exciting new ways to teach, they should not be the core of instructional planning, but rather selected only after learning objectives and instructional strategies have been identified. This paper provides an overview of prominent Web 2.0 applications, explains how they are being used within education environments, and elaborates on some of the potential opportunities and challenges that these applications present. PMID:19960079

The Sensor Web: A Macro-Instrument for Coordinated Sensing

Directory of Open Access Journals (Sweden)

Kevin A. Delin

2002-07-01

Full Text Available The Sensor Web is a macro-instrument concept that allows for the spatiotemporal understanding of an environment through coordinated efforts between multiple numbers and types of sensing platforms, including both orbital and terrestrial and both fixed and mobile. Each of these platforms, or pods, communicates within their local neighborhood and thus distributes information to the instrument as a whole. Much as intelligence in the brain is a result of the myriad of connections between dendrites, it is anticipated that the Sensor Web will develop a macro-intelligence as a result of its distributed information with the pods reacting and adapting to their environment in a way that is much more than their individual sum. The sharing of data among individual pods will allow for a global perception and purpose of the instrument as a whole. The Sensor Web is to sensors what the Internet is to computers, with different platforms and operating systems communicating via a set of shared, robust protocols. This paper will outline the potential of the Sensor Web concept and describe the Jet Propulsion Laboratory (JPL Sensor Webs Project (http://sensorwebs.jpl.nasa.gov/. In particular, various fielded Sensor Webs will be discussed.

IEEE 1451.1 Standard and XML Web Services: a Powerful Combination to Build Distributed Measurement and Control Systems

OpenAIRE

Viegas, Vítor; Pereira, José Dias; Girão, P. Silva

2006-01-01

In 2005, we presented the NCAP/XML, a prototype of NCAP (Network Capable Application Processor) that runs under the .NET Framework and makes available its functionality through a set of Web Services using XML (eXtended Markup Language). Giving continuity to this project, it is time to explain how to use the NCAP/XML to build a Distributed Measurement and Control System (DMCS) compliant with the 1451.1 Std. This paper is divided in two main parts: in the first part, we present the new software...

The LabelHash algorithm for substructure matching

Directory of Open Access Journals (Sweden)

Bryant Drew H

2010-11-01

Full Text Available Abstract Background There is an increasing number of proteins with known structure but unknown function. Determining their function would have a significant impact on understanding diseases and designing new therapeutics. However, experimental protein function determination is expensive and very time-consuming. Computational methods can facilitate function determination by identifying proteins that have high structural and chemical similarity. Results We present LabelHash, a novel algorithm for matching substructural motifs to large collections of protein structures. The algorithm consists of two phases. In the first phase the proteins are preprocessed in a fashion that allows for instant lookup of partial matches to any motif. In the second phase, partial matches for a given motif are expanded to complete matches. The general applicability of the algorithm is demonstrated with three different case studies. First, we show that we can accurately identify members of the enolase superfamily with a single motif. Next, we demonstrate how LabelHash can complement SOIPPA, an algorithm for motif identification and pairwise substructure alignment. Finally, a large collection of Catalytic Site Atlas motifs is used to benchmark the performance of the algorithm. LabelHash runs very efficiently in parallel; matching a motif against all proteins in the 95% sequence identity filtered non-redundant Protein Data Bank typically takes no more than a few minutes. The LabelHash algorithm is available through a web server and as a suite of standalone programs at http://labelhash.kavrakilab.org. The output of the LabelHash algorithm can be further analyzed with Chimera through a plugin that we developed for this purpose. Conclusions LabelHash is an efficient, versatile algorithm for large-scale substructure matching. When LabelHash is running in parallel, motifs can typically be matched against the entire PDB on the order of minutes. The algorithm is able to identify

Metabolism of [14C]bicarbonate by Streptococcus lactis: identification and distribution of labelled compounds

International Nuclear Information System (INIS)

Hillier, A.J.; Jago, G.R.

1978-01-01

Streptococcus lactis C10, grown in tryptone-yeast extract-lactose broth containing [ 14 C] bicarbonate, incorporated radioactivity into the protein and nucleic acid fractions of the cell as well as into compounds which were excreted by the organism into the growth medium. Aspartic acid was the first compound to be labelled and was the only amino acid labelled in the cell protein. All 4 bases were labelled in the cell RNA. Aspartic, succunuc and lactic acids were the radioactive compounds excreted into the growth medium. (U.K.)

Caught in the Web

International Nuclear Information System (INIS)

Gillies, James

1995-01-01

The World-Wide Web may have taken the Internet by storm, but many people would be surprised to learn that it owes its existence to CERN. Around half the world's particle physicists come to CERN for their experiments, and the Web is the result of their need to share information quickly and easily on a global scale. Six years after Tim Berners-Lee's inspired idea to marry hypertext to the Internet in 1989, CERN is handing over future Web development to the World-Wide Web Consortium, run by the French National Institute for Research in Computer Science and Control, INRIA, and the Laboratory for Computer Science of the Massachusetts Institute of Technology, MIT, leaving itself free to concentrate on physics. The Laboratory marked this transition with a conference designed to give a taste of what the Web can do, whilst firmly stamping it with the label ''Made in CERN''. Over 200 European journalists and educationalists came to CERN on 8 - 9 March for the World-Wide Web Days, resulting in wide media coverage. The conference was opened by UK Science Minister David Hunt who stressed the importance of fundamental research in generating new ideas. ''Who could have guessed 10 years ago'', he said, ''that particle physics research would lead to a communication system which would allow every school to have the biggest library in the world in a single computer?''. In his introduction, the Minister also pointed out that ''CERN and other basic research laboratories help to break new technological ground and sow the seeds of what will become mainstream manufacturing in the future.'' Learning the jargon is often the hardest part of coming to grips with any new invention, so CERN put it at the top of the agenda. Jacques Altaber, who helped introduce the Internet to CERN in the early 1980s, explained that without the Internet, the Web couldn't exist. The Internet began as a US Defense

UK quantitative WB-DWI technical workgroup: consensus meeting recommendations on optimisation, quality control, processing and analysis of quantitative whole-body diffusion-weighted imaging for cancer.

Science.gov (United States)

Barnes, Anna; Alonzi, Roberto; Blackledge, Matthew; Charles-Edwards, Geoff; Collins, David J; Cook, Gary; Coutts, Glynn; Goh, Vicky; Graves, Martin; Kelly, Charles; Koh, Dow-Mu; McCallum, Hazel; Miquel, Marc E; O'Connor, James; Padhani, Anwar; Pearson, Rachel; Priest, Andrew; Rockall, Andrea; Stirling, James; Taylor, Stuart; Tunariu, Nina; van der Meulen, Jan; Walls, Darren; Winfield, Jessica; Punwani, Shonit

2018-01-01

Application of whole body diffusion-weighted MRI (WB-DWI) for oncology are rapidly increasing within both research and routine clinical domains. However, WB-DWI as a quantitative imaging biomarker (QIB) has significantly slower adoption. To date, challenges relating to accuracy and reproducibility, essential criteria for a good QIB, have limited widespread clinical translation. In recognition, a UK workgroup was established in 2016 to provide technical consensus guidelines (to maximise accuracy and reproducibility of WB-MRI QIBs) and accelerate the clinical translation of quantitative WB-DWI applications for oncology. A panel of experts convened from cancer centres around the UK with subspecialty expertise in quantitative imaging and/or the use of WB-MRI with DWI. A formal consensus method was used to obtain consensus agreement regarding best practice. Questions were asked about the appropriateness or otherwise on scanner hardware and software, sequence optimisation, acquisition protocols, reporting, and ongoing quality control programs to monitor precision and accuracy and agreement on quality control. The consensus panel was able to reach consensus on 73% (255/351) items and based on consensus areas made recommendations to maximise accuracy and reproducibly of quantitative WB-DWI studies performed at 1.5T. The panel were unable to reach consensus on the majority of items related to quantitative WB-DWI performed at 3T. This UK Quantitative WB-DWI Technical Workgroup consensus provides guidance on maximising accuracy and reproducibly of quantitative WB-DWI for oncology. The consensus guidance can be used by researchers and clinicians to harmonise WB-DWI protocols which will accelerate clinical translation of WB-DWI-derived QIBs.

Towards the Semantic Web

NARCIS (Netherlands)

Davies, John; Fensel, Dieter; Harmelen, Frank Van

2003-01-01

With the current changes driven by the expansion of the World Wide Web, this book uses a different approach from other books on the market: it applies ontologies to electronically available information to improve the quality of knowledge management in large and distributed organizations. Ontologies

Web-Enabled ATR/Fusion Development System

National Research Council Canada - National Science Library

Ruda, Harald

2001-01-01

.... We have designed a Web-Enabled ATR/Fusion Development System (WEADS) that will allow distributed development and execution of AIR and fusion algorithms using currently available infrastructures...

Application of ESE Data and Tools to Air Quality Management: Services for Helping the Air Quality Community use ESE Data (SHAirED)

Science.gov (United States)

Falke, Stefan; Husar, Rudolf

2011-01-01

The goal of this REASoN applications and technology project is to deliver and use Earth Science Enterprise (ESE) data and tools in support of air quality management. Its scope falls within the domain of air quality management and aims to develop a federated air quality information sharing network that includes data from NASA, EPA, US States and others. Project goals were achieved through a access of satellite and ground observation data, web services information technology, interoperability standards, and air quality community collaboration. In contributing to a network of NASA ESE data in support of particulate air quality management, the project will develop access to distributed data, build Web infrastructure, and create tools for data processing and analysis. The key technologies used in the project include emerging web services for developing self describing and modular data access and processing tools, and service oriented architecture for chaining web services together to assemble customized air quality management applications. The technology and tools required for this project were developed within DataFed.net, a shared infrastructure that supports collaborative atmospheric data sharing and processing web services. Much of the collaboration was facilitated through community interactions through the Federation of Earth Science Information Partners (ESIP) Air Quality Workgroup. The main activities during the project that successfully advanced DataFed, enabled air quality applications and established community-oriented infrastructures were: develop access to distributed data (surface and satellite), build Web infrastructure to support data access, processing and analysis create tools for data processing and analysis foster air quality community collaboration and interoperability.

Numerical analysis of beam with sinusoidally corrugated webs

Science.gov (United States)

Górecki, Marcin; Pieńko, Michał; Łagoda, GraŻyna

2018-01-01

The paper presents numerical tests results of the steel beam with sinusoidally corrugated web, which were performed in the Autodesk Algor Simulation Professional 2010. The analysis was preceded by laboratory tests including the beam's work under the influence of the four point bending as well as the study of material characteristics. Significant web's thickness and use of tools available in the software allowed to analyze the behavior of the plate girder as beam, and also to observe the occurrence of stresses in the characteristic element - the corrugated web. The stress distribution observed on the both web's surfaces was analyzed.

A Method for Transforming Existing Web Service Descriptions into an Enhanced Semantic Web Service Framework

Science.gov (United States)

Du, Xiaofeng; Song, William; Munro, Malcolm

Web Services as a new distributed system technology has been widely adopted by industries in the areas, such as enterprise application integration (EAI), business process management (BPM), and virtual organisation (VO). However, lack of semantics in the current Web Service standards has been a major barrier in service discovery and composition. In this chapter, we propose an enhanced context-based semantic service description framework (CbSSDF+) that tackles the problem and improves the flexibility of service discovery and the correctness of generated composite services. We also provide an agile transformation method to demonstrate how the various formats of Web Service descriptions on the Web can be managed and renovated step by step into CbSSDF+ based service description without large amount of engineering work. At the end of the chapter, we evaluate the applicability of the transformation method and the effectiveness of CbSSDF+ through a series of experiments.

Positron emitter labeled enzyme inhibitors

International Nuclear Information System (INIS)

Fowler, J.S.; MacGregor, R.R.; Wolf, A.P.; Langstrom, B.

1990-01-01

This invention involves a new strategy for imagining and mapping enzyme activity in the living human and animal body using positron emitter-labeled suicide enzyme inactivators or inhibitors which become covalently bound to the enzyme as a result of enzymatic catalysis. Two such suicide inactivators for monoamine oxidase have been labeled with carbon-11 and used to map the enzyme subtypes in the living human and animal body using PET. By using positron emission tomography to image the distribution of radioactivity produced by the body penetrating radiation emitted by carbon-11, a map of functionally active monoamine oxidase activity is obtained. Clorgyline and L-deprenyl are suicide enzyme inhibitors and irreversibly inhibit monoamine oxidase. When these inhibitors are labeled with carbon-11 they provide selective probes for monoamine oxidase localization and reactivity in vivo using positron emission tomography

The DIRAC Web Portal 2.0

Science.gov (United States)

Mathe, Z.; Casajus Ramo, A.; Lazovsky, N.; Stagni, F.

2015-12-01

For many years the DIRAC interware (Distributed Infrastructure with Remote Agent Control) has had a web interface, allowing the users to monitor DIRAC activities and also interact with the system. Since then many new web technologies have emerged, therefore a redesign and a new implementation of the DIRAC Web portal were necessary, taking into account the lessons learnt using the old portal. These new technologies allowed to build a more compact, robust and responsive web interface that enables users to have better control over the whole system while keeping a simple interface. The web framework provides a large set of “applications”, each of which can be used for interacting with various parts of the system. Communities can also create their own set of personalised web applications, and can easily extend already existing ones with a minimal effort. Each user can configure and personalise the view for each application and save it using the DIRAC User Profile service as RESTful state provider, instead of using cookies. The owner of a view can share it with other users or within a user community. Compatibility between different browsers is assured, as well as with mobile versions. In this paper, we present the new DIRAC Web framework as well as the LHCb extension of the DIRAC Web portal.

The Geogenomic Mutational Atlas of Pathogens (GoMAP web system.

Directory of Open Access Journals (Sweden)

David P Sargeant

Full Text Available We present a new approach for pathogen surveillance we call Geogenomics. Geogenomics examines the geographic distribution of the genomes of pathogens, with a particular emphasis on those mutations that give rise to drug resistance. We engineered a new web system called Geogenomic Mutational Atlas of Pathogens (GoMAP that enables investigation of the global distribution of individual drug resistance mutations. As a test case we examined mutations associated with HIV resistance to FDA-approved antiretroviral drugs. GoMAP-HIV makes use of existing public drug resistance and HIV protein sequence data to examine the distribution of 872 drug resistance mutations in ∼ 502,000 sequences for many countries in the world. We also implemented a broadened classification scheme for HIV drug resistance mutations. Several patterns for geographic distributions of resistance mutations were identified by visual mining using this web tool. GoMAP-HIV is an open access web application available at http://www.bio-toolkit.com/GoMap/project/

76 FR 76740 - Secretary's Advisory Committee on Heritable Disorders in Newborns and Children; Notice of Meeting

Science.gov (United States)

2011-12-08

... (HRSA), and the Maternal and Child Health Bureau; (2) the history of the Advisory Committee; (3) an... Impact Workgroup for further evaluation; (4) reviewing the report on Linking Birth Certificates and..., presentations, and meeting materials can be found at the home page of the Advisory Committee's Web site at http...

TENCompetence

NARCIS (Netherlands)

Luccini, A.Marco; Dicerto, Michele; Sloep, Peter; Koper, Rob; Kew, Chris; Olmedilla, Daniel; Demidova, Elena

2006-01-01

This very technical meeting hosted by Giunti Labs in Sestri Levante (Italy) on 13-14 November 2006, has provided the great opportunity to present "European perspectives on the application of web services to learning" to a set of big actors in the elearnig field in the framework of the WSIL workgroup

Tierless Web programming in ML

OpenAIRE

Radanne , Gabriel

2017-01-01

Eliom is a dialect of OCaml for Web programming in which server and client pieces of code can be mixed in the same file using syntactic annotations. This allows to build a whole application as a single distributed program, in which it is possible to define in a composable way reusable widgets with both server and client behaviors. Eliom is type-safe, as it ensures that communications are well-behaved through novel language constructs that match the specificity of Web programming. Eliom is als...

The ''in vivo'' distribution of carbon 11 labeled-nicotine in animals. A method suitable for use in man

International Nuclear Information System (INIS)

Maziere, M.; Berger, G.; Plummer, D.; Comar, D.; Masse, R.

1978-01-01

A method is described to label nicotine with carbon 11. A hundred millicuries can be obtained, in 45 minutes, with a high specific activity. This labeling of nicotine has allowed an ''in vivo'' study of the distribution of this very toxic drug in animals. Five minutes after injection in rabbits or monkeys, it was shown with a gamma camera or with a positron camera that the radioactivity was very rapidly distributed throughout the tissues especially in brain, lungs and kidneys. 11 C-nicotine readily penetrates the blood-brain barrier and the brain radioactivity decreases very sharply with time. The eyes however retained activity, possibly in the retina. Unfortunately the monkey is not the ideal subject for 11 C-nicotine brain study because: the brain is small, considering the resolution of the cameras and the cerebral lobes are also quite overlaped in this animal; Japanese authors have shown that compared with dogs the nicotine brain uptake is lower, due to the high affinity of nicotine for skeletal muscle which occupies approximately forty to fifty % of the body weight of the monkey. Also in monkeys, the nicotine destruction is faster than in dogs because there is a higher enzyme nicotine metabolizing activity in the liver of this animal. The differences observed between various animals studies using nicotine indicate that we should not draw any firm conclusions about the behaviour of this drug in humans. In order to do so, examinations must be conducted in man and the method described in spite of its limitations provides a means for such a study

Increasing efficiency of information dissemination and collection through the World Wide Web

Science.gov (United States)

Daniel P. Huebner; Malchus B. Baker; Peter F. Ffolliott

2000-01-01

Researchers, managers, and educators have access to revolutionary technology for information transfer through the World Wide Web (Web). Using the Web to effectively gather and distribute information is addressed in this paper. Tools, tips, and strategies are discussed. Companion Web sites are provided to guide users in selecting the most appropriate tool for searching...

Building Grid applications using Web Services

CERN Multimedia

CERN. Geneva

2004-01-01

There has been a lot of discussion within the Grid community about the use of Web Services technologies in building large-scale, loosely-coupled, cross-organisation applications. In this talk we are going to explore the principles that govern Service-Oriented Architectures and the promise of Web Services technologies for integrating applications that span administrative domains. We are going to see how existing Web Services specifications and practices could provide the necessary infrastructure for implementing Grid applications. Biography Dr. Savas Parastatidis is a Principal Research Associate at the School of Computing Science, University of Newcastle upon Tyne, UK. Savas is one of the authors of the "Grid Application Framework based on Web Services Specifications and Practices" document that was influential in the convergence between Grid and Web Services and the move away from OGSI (more information can be found at http://www.neresc.ac.uk/ws-gaf). He has done research on runtime support for distributed-m...

Web Page Recommendation Using Web Mining

OpenAIRE

Modraj Bhavsar; Mrs. P. M. Chavan

2014-01-01

On World Wide Web various kind of content are generated in huge amount, so to give relevant result to user web recommendation become important part of web application. On web different kind of web recommendation are made available to user every day that includes Image, Video, Audio, query suggestion and web page. In this paper we are aiming at providing framework for web page recommendation. 1) First we describe the basics of web mining, types of web mining. 2) Details of each...

Managing uncertainty in integrated environmental modelling: The UncertWeb framework.

NARCIS (Netherlands)

Bastin, L.; Cornford, D.; Jones, R.; Heuvelink, G.B.M.; Pebesma, E.; Stasch, C.; Nativi, S.; Mazzetti, P.

2013-01-01

Web-based distributed modelling architectures are gaining increasing recognition as potentially useful tools to build holistic environmental models, combining individual components in complex workflows. However, existing web-based modelling frameworks currently offer no support for managing

Distribution and Validation of CERES Irradiance Global Data Products Via Web Based Tools

Science.gov (United States)

Rutan, David; Mitrescu, Cristian; Doelling, David; Kato, Seiji

2016-01-01

The CERES SYN1deg product provides climate quality 3-hourly globally gridded and temporally complete maps of top of atmosphere, in atmosphere, and surface fluxes. This product requires efficient release to the public and validation to maintain quality assurance. The CERES team developed web-tools for the distribution of both the global gridded products and grid boxes that contain long term validation sites that maintain high quality flux observations at the Earth's surface. These are found at: http://ceres.larc.nasa.gov/order_data.php. In this poster we explore the various tools available to users to sub-set, download, and validate using surface observations the SYN1Deg and Surface-EBAF products. We also analyze differences found in long-term records from well-maintained land surface sites such as the ARM central facility and high quality buoy radiometers, which due to their isolated nature cannot be maintained in a similar manner to their land based counterparts.

Profiling structured product labeling with NDF-RT and RxNorm

Science.gov (United States)

2012-01-01

Background Structured Product Labeling (SPL) is a document markup standard approved by Health Level Seven (HL7) and adopted by United States Food and Drug Administration (FDA) as a mechanism for exchanging drug product information. The SPL drug labels contain rich information about FDA approved clinical drugs. However, the lack of linkage to standard drug ontologies hinders their meaningful use. NDF-RT (National Drug File Reference Terminology) and NLM RxNorm as standard drug ontology were used to standardize and profile the product labels. Methods In this paper, we present a framework that intends to map SPL drug labels with existing drug ontologies: NDF-RT and RxNorm. We also applied existing categorical annotations from the drug ontologies to classify SPL drug labels into corresponding classes. We established the classification and relevant linkage for SPL drug labels using the following three approaches. First, we retrieved NDF-RT categorical information from the External Pharmacologic Class (EPC) indexing SPLs. Second, we used the RxNorm and NDF-RT mappings to classify and link SPLs with NDF-RT categories. Third, we profiled SPLs using RxNorm term type information. In the implementation process, we employed a Semantic Web technology framework, in which we stored the data sets from NDF-RT and SPLs into a RDF triple store, and executed SPARQL queries to retrieve data from customized SPARQL endpoints. Meanwhile, we imported RxNorm data into MySQL relational database. Results In total, 96.0% SPL drug labels were mapped with NDF-RT categories whereas 97.0% SPL drug labels are linked to RxNorm codes. We found that the majority of SPL drug labels are mapped to chemical ingredient concepts in both drug ontologies whereas a relatively small portion of SPL drug labels are mapped to clinical drug concepts. Conclusions The profiling outcomes produced by this study would provide useful insights on meaningful use of FDA SPL drug labels in clinical applications through

Profiling structured product labeling with NDF-RT and RxNorm

Directory of Open Access Journals (Sweden)

Zhu Qian

2012-12-01

Full Text Available Abstract Background Structured Product Labeling (SPL is a document markup standard approved by Health Level Seven (HL7 and adopted by United States Food and Drug Administration (FDA as a mechanism for exchanging drug product information. The SPL drug labels contain rich information about FDA approved clinical drugs. However, the lack of linkage to standard drug ontologies hinders their meaningful use. NDF-RT (National Drug File Reference Terminology and NLM RxNorm as standard drug ontology were used to standardize and profile the product labels. Methods In this paper, we present a framework that intends to map SPL drug labels with existing drug ontologies: NDF-RT and RxNorm. We also applied existing categorical annotations from the drug ontologies to classify SPL drug labels into corresponding classes. We established the classification and relevant linkage for SPL drug labels using the following three approaches. First, we retrieved NDF-RT categorical information from the External Pharmacologic Class (EPC indexing SPLs. Second, we used the RxNorm and NDF-RT mappings to classify and link SPLs with NDF-RT categories. Third, we profiled SPLs using RxNorm term type information. In the implementation process, we employed a Semantic Web technology framework, in which we stored the data sets from NDF-RT and SPLs into a RDF triple store, and executed SPARQL queries to retrieve data from customized SPARQL endpoints. Meanwhile, we imported RxNorm data into MySQL relational database. Results In total, 96.0% SPL drug labels were mapped with NDF-RT categories whereas 97.0% SPL drug labels are linked to RxNorm codes. We found that the majority of SPL drug labels are mapped to chemical ingredient concepts in both drug ontologies whereas a relatively small portion of SPL drug labels are mapped to clinical drug concepts. Conclusions The profiling outcomes produced by this study would provide useful insights on meaningful use of FDA SPL drug labels in clinical

Profiling structured product labeling with NDF-RT and RxNorm.

Science.gov (United States)

Zhu, Qian; Jiang, Guoqian; Chute, Christopher G

2012-12-20

Structured Product Labeling (SPL) is a document markup standard approved by Health Level Seven (HL7) and adopted by United States Food and Drug Administration (FDA) as a mechanism for exchanging drug product information. The SPL drug labels contain rich information about FDA approved clinical drugs. However, the lack of linkage to standard drug ontologies hinders their meaningful use. NDF-RT (National Drug File Reference Terminology) and NLM RxNorm as standard drug ontology were used to standardize and profile the product labels. In this paper, we present a framework that intends to map SPL drug labels with existing drug ontologies: NDF-RT and RxNorm. We also applied existing categorical annotations from the drug ontologies to classify SPL drug labels into corresponding classes. We established the classification and relevant linkage for SPL drug labels using the following three approaches. First, we retrieved NDF-RT categorical information from the External Pharmacologic Class (EPC) indexing SPLs. Second, we used the RxNorm and NDF-RT mappings to classify and link SPLs with NDF-RT categories. Third, we profiled SPLs using RxNorm term type information. In the implementation process, we employed a Semantic Web technology framework, in which we stored the data sets from NDF-RT and SPLs into a RDF triple store, and executed SPARQL queries to retrieve data from customized SPARQL endpoints. Meanwhile, we imported RxNorm data into MySQL relational database. In total, 96.0% SPL drug labels were mapped with NDF-RT categories whereas 97.0% SPL drug labels are linked to RxNorm codes. We found that the majority of SPL drug labels are mapped to chemical ingredient concepts in both drug ontologies whereas a relatively small portion of SPL drug labels are mapped to clinical drug concepts. The profiling outcomes produced by this study would provide useful insights on meaningful use of FDA SPL drug labels in clinical applications through standard drug ontologies such as NDF-RT and

Exploiting Multimedia in Creating and Analysing Multimedia Web Archives

Directory of Open Access Journals (Sweden)

Jonathon S. Hare

2014-04-01

Full Text Available The data contained on the web and the social web are inherently multimedia and consist of a mixture of textual, visual and audio modalities. Community memories embodied on the web and social web contain a rich mixture of data from these modalities. In many ways, the web is the greatest resource ever created by human-kind. However, due to the dynamic and distributed nature of the web, its content changes, appears and disappears on a daily basis. Web archiving provides a way of capturing snapshots of (parts of the web for preservation and future analysis. This paper provides an overview of techniques we have developed within the context of the EU funded ARCOMEM (ARchiving COmmunity MEMories project to allow multimedia web content to be leveraged during the archival process and for post-archival analysis. Through a set of use cases, we explore several practical applications of multimedia analytics within the realm of web archiving, web archive analysis and multimedia data on the web in general.

LHCb : The DIRAC Web Portal 2.0

CERN Multimedia

Mathe, Zoltan; Lazovsky, N; Stagni, Federico

2015-01-01

For many years the DIRAC interware (Distributed Infrastructure with Remote Agent Control) has had a web interface, allowing the users to monitor DIRAC activities and also interact with the system. Since then many new web technologies have emerged, therefore a redesign and a new implementation of the DIRAC Web portal were necessary, taking into account the lessons learnt using the old portal. These new technologies allowed to build a more compact and more responsive web interface that is robust and that enables users to have more control over the whole system while keeping a simple interface. The framework provides a large set of "applications", each of which can be used for interacting with various parts of the system. Communities can also create their own set of personalised web applications, and can easily extend already existing web applications with a minimal effort. Each user can configure and personalise the view for each application and save it using the DIRAC User Profile service as RESTful state prov...

Generating Realistic Labelled, Weighted Random Graphs

Directory of Open Access Journals (Sweden)

Michael Charles Davis

2015-12-01

Full Text Available Generative algorithms for random graphs have yielded insights into the structure and evolution of real-world networks. Most networks exhibit a well-known set of properties, such as heavy-tailed degree distributions, clustering and community formation. Usually, random graph models consider only structural information, but many real-world networks also have labelled vertices and weighted edges. In this paper, we present a generative model for random graphs with discrete vertex labels and numeric edge weights. The weights are represented as a set of Beta Mixture Models (BMMs with an arbitrary number of mixtures, which are learned from real-world networks. We propose a Bayesian Variational Inference (VI approach, which yields an accurate estimation while keeping computation times tractable. We compare our approach to state-of-the-art random labelled graph generators and an earlier approach based on Gaussian Mixture Models (GMMs. Our results allow us to draw conclusions about the contribution of vertex labels and edge weights to graph structure.

HON label and DISCERN as content quality indicators of health-related websites.

Science.gov (United States)

Khazaal, Yasser; Chatton, Anne; Zullino, Daniele; Khan, Riaz

2012-03-01

Content quality indicators are warranted in order to help patients and consumers to judge the content quality of health-related on-line information. The aim of the present study is to evaluate web-based information on health topics and to assess particular content quality indicators like HON (Health on the Net) and DISCERN. The present study is based on the analysis of data issued from six previous studies which assessed with a standardized tool the general and content quality (evidence-based health information) of health-related websites. Keywords related to Social phobia, bipolar disorders, pathological gambling as well as cannabis, alcohol and cocaine addiction were entered into popular World Wide Web search engines. Websites were assessed with a standardized proforma designed to rate sites on the basis of accountability, presentation, interactivity, readability and content quality (evidence-based information). "Health on the Net" (HON) quality label, and DISCERN scale scores were used to verify their efficiency as quality indicators. Of 874 websites identified, 388 were included. Despite an observed association with higher content quality scores, the HON label fails to predict good content quality websites when used in a multiple regression. Sensibility and specificity of a DISCERN score >40 in the detection of good content quality websites were, respectively, 0.45 and 0.96. The DISCERN is a potential quality indicator with a relatively high specificity. Further developments in this domain are warranted in order to facilitate the identification of high-quality information on the web by patients.

Preparation of 35S-labelled albendazole sulfinyl (ABZO)

International Nuclear Information System (INIS)

Zhang Lufang; Wu Yuanfang; Yang Zhiming

1992-01-01

Albendazole is an important insecticide and albendazole sulfinyl (ABZO) is the effective component. In order to investigate its absorption, distribution and excretion in vivo, 35 S-labelled tracer was necessary for experiment. 35 S-labelled intermediate was made by isotopic exchange. The radiochemical yield was over 90%. After purification by TLC, the radiochemical purity of the 35 S-ABZO determined by PC and electrophoresis was over 95%

ADVERPred-Web Service for Prediction of Adverse Effects of Drugs.

Science.gov (United States)

Ivanov, Sergey M; Lagunin, Alexey A; Rudik, Anastasia V; Filimonov, Dmitry A; Poroikov, Vladimir V

2018-01-22

Application of structure-activity relationships (SARs) for the prediction of adverse effects of drugs (ADEs) has been reported in many published studies. Training sets for the creation of SAR models are usually based on drug label information which allows for the generation of data sets for many hundreds of drugs. Since many ADEs may not be related to drug consumption, one of the main problems in such studies is the quality of data on drug-ADE pairs obtained from labels. The information on ADEs may be included in three sections of the drug labels: "Boxed warning," "Warnings and Precautions," and "Adverse reactions." The first two sections, especially Boxed warning, usually contain the most frequent and severe ADEs that have either known or probable relationships to drug consumption. Using this information, we have created manually curated data sets for the five most frequent and severe ADEs: myocardial infarction, arrhythmia, cardiac failure, severe hepatotoxicity, and nephrotoxicity, with more than 850 drugs on average for each effect. The corresponding SARs were built with PASS (Prediction of Activity Spectra for Substances) software and had balanced accuracy values of 0.74, 0.7, 0.77, 0.67, and 0.75, respectively. They were implemented in a freely available ADVERPred web service ( http://www.way2drug.com/adverpred/ ), which enables a user to predict five ADEs based on the structural formula of compound. This web service can be applied for estimation of the corresponding ADEs for hits and lead compounds at the early stages of drug discovery.

Food-web dynamics in a large river discontinuum

Science.gov (United States)

Cross, Wyatt F.; Baxter, Colden V.; Rosi-Marshall, Emma J.; Hall, Robert O.; Kennedy, Theodore A.; Donner, Kevin C.; Kelly, Holly A. Wellard; Seegert, Sarah E.Z.; Behn, Kathrine E.; Yard, Michael D.

2013-01-01

Nearly all ecosystems have been altered by human activities, and most communities are now composed of interacting species that have not co-evolved. These changes may modify species interactions, energy and material flows, and food-web stability. Although structural changes to ecosystems have been widely reported, few studies have linked such changes to dynamic food-web attributes and patterns of energy flow. Moreover, there have been few tests of food-web stability theory in highly disturbed and intensely managed freshwater ecosystems. Such synthetic approaches are needed for predicting the future trajectory of ecosystems, including how they may respond to natural or anthropogenic perturbations. We constructed flow food webs at six locations along a 386-km segment of the Colorado River in Grand Canyon (Arizona, USA) for three years. We characterized food-web structure and production, trophic basis of production, energy efficiencies, and interaction-strength distributions across a spatial gradient of perturbation (i.e., distance from Glen Canyon Dam), as well as before and after an experimental flood. We found strong longitudinal patterns in food-web characteristics that strongly correlated with the spatial position of large tributaries. Above tributaries, food webs were dominated by nonnative New Zealand mudsnails (62% of production) and nonnative rainbow trout (100% of fish production). The simple structure of these food webs led to few dominant energy pathways (diatoms to few invertebrate taxa to rainbow trout), large energy inefficiencies (i.e., Below large tributaries, invertebrate production declined ∼18-fold, while fish production remained similar to upstream sites and comprised predominately native taxa (80–100% of production). Sites below large tributaries had increasingly reticulate and detritus-based food webs with a higher prevalence of omnivory, as well as interaction strength distributions more typical of theoretically stable food webs (i

Beyond Native Apps: Web Technologies to the Rescue! (Keynote)

NARCIS (Netherlands)

Malavolta, Ivano

2016-01-01

As of today, mobile software development teams can follow a number of different development and distribution strategies, ranging from native apps, to mobile web apps, hybrid apps, and the recently emerging progressive web apps. This talk provides a state-of-the-art overview of the development

Modeling and validating HL7 FHIR profiles using semantic web Shape Expressions (ShEx).

Science.gov (United States)

Solbrig, Harold R; Prud'hommeaux, Eric; Grieve, Grahame; McKenzie, Lloyd; Mandel, Joshua C; Sharma, Deepak K; Jiang, Guoqian

2017-03-01

HL7 Fast Healthcare Interoperability Resources (FHIR) is an emerging open standard for the exchange of electronic healthcare information. FHIR resources are defined in a specialized modeling language. FHIR instances can currently be represented in either XML or JSON. The FHIR and Semantic Web communities are developing a third FHIR instance representation format in Resource Description Framework (RDF). Shape Expressions (ShEx), a formal RDF data constraint language, is a candidate for describing and validating the FHIR RDF representation. Create a FHIR to ShEx model transformation and assess its ability to describe and validate FHIR RDF data. We created the methods and tools that generate the ShEx schemas modeling the FHIR to RDF specification being developed by HL7 ITS/W3C RDF Task Force, and evaluated the applicability of ShEx in the description and validation of FHIR to RDF transformations. The ShEx models contributed significantly to workgroup consensus. Algorithmic transformations from the FHIR model to ShEx schemas and FHIR example data to RDF transformations were incorporated into the FHIR build process. ShEx schemas representing 109 FHIR resources were used to validate 511 FHIR RDF data examples from the Standards for Trial Use (STU 3) Ballot version. We were able to uncover unresolved issues in the FHIR to RDF specification and detect 10 types of errors and root causes in the actual implementation. The FHIR ShEx representations have been included in the official FHIR web pages for the STU 3 Ballot version since September 2016. ShEx can be used to define and validate the syntax of a FHIR resource, which is complementary to the use of RDF Schema (RDFS) and Web Ontology Language (OWL) for semantic validation. ShEx proved useful for describing a standard model of FHIR RDF data. The combination of a formal model and a succinct format enabled comprehensive review and automated validation. Copyright © 2017 Elsevier Inc. All rights reserved.

Ecological significance of hazardous concentrations in a planktonic food web

OpenAIRE

De Laender, F.; Soetaert, K.; De Schamphelaere, K.A.C.; Middelburg, J.J.; Janssen, C.R.

2010-01-01

Species sensitivity distributions (SSDs) are statistical distributions that are used to estimate the potentially affected fraction (PAF) of species at a given toxicant concentration, the hazardous concentration for that fraction of species (HCPAF). Here, we use an aquatic food web model that includes 14 phytoplankton and 6 zooplankton species to estimate the number of species experiencing a biomass reduction when the food web is exposed to the HCPAF and this for 1000 hypothetical toxicants an...

78 FR 8446 - Center for Drug Evaluation and Research; Prescription Drug Labeling Improvement and Enhancement...

Science.gov (United States)

2013-02-06

... utility of the prescription drug labeling as a communication tool and to discuss strategies for making it... the Web site after this document publishes in the Federal Register.) All holders of marketing... before June 30, 2001, and for generic drugs. The initiative is anticipated to take place over several...

Improving clinical cognitive testing: report of the AAN Behavioral Neurology Section Workgroup.

Science.gov (United States)

Daffner, Kirk R; Gale, Seth A; Barrett, A M; Boeve, Bradley F; Chatterjee, Anjan; Coslett, H Branch; D'Esposito, Mark; Finney, Glen R; Gitelman, Darren R; Hart, John J; Lerner, Alan J; Meador, Kimford J; Pietras, Alison C; Voeller, Kytja S; Kaufer, Daniel I

2015-09-08

To evaluate the evidence basis of single-domain cognitive tests frequently used by behavioral neurologists in an effort to improve the quality of clinical cognitive assessment. Behavioral Neurology Section members of the American Academy of Neurology were surveyed about how they conduct clinical cognitive testing, with a particular focus on the Neurobehavioral Status Exam (NBSE). In contrast to general screening cognitive tests, an NBSE consists of tests of individual cognitive domains (e.g., memory or language) that provide a more comprehensive diagnostic assessment. Workgroups for each of 5 cognitive domains (attention, executive function, memory, language, and spatial cognition) conducted evidence-based reviews of frequently used tests. Reviews focused on suitability for office-based clinical practice, including test administration time, accessibility of normative data, disease populations studied, and availability in the public domain. Demographic and clinical practice data were obtained from 200 respondents who reported using a wide range of cognitive tests. Based on survey data and ancillary information, between 5 and 15 tests in each cognitive domain were reviewed. Within each domain, several tests are highlighted as being well-suited for an NBSE. We identified frequently used single-domain cognitive tests that are suitable for an NBSE to help make informed choices about clinical cognitive assessment. Some frequently used tests have limited normative data or have not been well-studied in common neurologic disorders. Utilizing standardized cognitive tests, particularly those with normative data based on the individual's age and educational level, can enhance the rigor and utility of clinical cognitive assessment. © 2015 American Academy of Neurology.

The geospatial web how geobrowsers, social software and the web 2 0 are shaping the network society

CERN Document Server

Scharl, Arno; Tochtermann, Klaus

2007-01-01

The Geospatial Web will have a profound impact on managing knowledge, structuring work flows within and across organizations, and communicating with like-minded individuals in virtual communities. The enabling technologies for the Geospatial Web are geo-browsers such as NASA World Wind, Google Earth and Microsoft Live Local 3D. These three-dimensional platforms revolutionize the production and consumption of media products. They not only reveal the geographic distribution of Web resources and services, but also bring together people of similar interests, browsing behavior, or geographic location. This book summarizes the latest research on the Geospatial Web's technical foundations, describes information services and collaborative tools built on top of geo-browsers, and investigates the environmental, social and economic impacts of geospatial applications. The role of contextual knowledge in shaping the emerging network society deserves particular attention. By integrating geospatial and semantic technology, ...

Somatostatin analogues labelled with 99mTc

International Nuclear Information System (INIS)

Obenaus, Esteban R.; Crudo, Jose L.; Edreira, Martin M.; Castiglia, Silvia G.

1999-01-01

Biological and radiochemical studies have been carried out on two labelled somatostatin analogues, the peptide RC-150 and the Tyr 3 -Octreotide. Both analogues have been labelled with 99m Tc using the direct and the indirect method and MAG-3 and HYNIC as chelating agents. By the direct method RC-150 was labelled using sodium ascorbate and dithionite as reducing agents. The radiochemical purity was 70%. By the indirect method, in the case of RC-160 with MAG-3 a radiochemical purity higher than 70% was attained while a purity of 100% was reached in the case of Tyr 3 -Octreotide with HYNIC. The biological distribution of HYNIC-Tyr 3 -Octreotide has been studied in rats. (author)

Subcellular SIMS imaging of isotopically labeled amino acids in cryogenically prepared cells

International Nuclear Information System (INIS)

Chandra, Subhash

2004-01-01

Ion microscopy is a potentially powerful technique for localization of isotopically labeled molecules. In this study, L-arginine and phenylalanine amino acids labeled with stable isotopes 13 C and 15 N were localized in cultured cells with the ion microscope at 500 nm spatial resolution. Cells were exposed to the labeled amino acids and cryogenically prepared. SIMS analyses were made in fractured freeze-dried cells. A dynamic distribution was observed from labeled arginine-treated LLC-PK 1 kidney cells at mass 28 ( 13 C 15 N) in negative secondaries, revealing cell-to-cell heterogeneity and preferential accumulation of the amino acid (or its metabolite) in the nucleus and nucleolus of some cells. The smaller nucleolus inside the nucleus was clearly resolved in SIMS images and confirmed by correlative light microscopy. The distribution of labeled phenylalanine contrasted with arginine as it was rather homogeneously distributed in T98G human glioblastoma cells. Images of 39 K, 23 Na and 40 Ca were also recorded to confirm the reliability of sample preparation and authenticity of the observed amino acid distributions. These observations indicate that SIMS techniques can provide a valuable technology for subcellular localization of nitrogen-containing molecules in proteomics since nitrogen does not have a radionuclide tracer isotope. Amino acids labeled with stable isotopes can be used as tracers for studying their transport and metabolism in distinct subcellular compartments with SIMS. Further studies of phenylalanine uptake in human glioblastoma cells may have special significance in boron neutron capture therapy (BNCT) as a boron analogue of phenylalanine, boronophenylalanine is a clinically approved compound for the treatment of brain tumors

Subcellular SIMS imaging of isotopically labeled amino acids in cryogenically prepared cells

Energy Technology Data Exchange (ETDEWEB)

Chandra, Subhash

2004-06-15

Ion microscopy is a potentially powerful technique for localization of isotopically labeled molecules. In this study, L-arginine and phenylalanine amino acids labeled with stable isotopes {sup 13}C and {sup 15}N were localized in cultured cells with the ion microscope at 500 nm spatial resolution. Cells were exposed to the labeled amino acids and cryogenically prepared. SIMS analyses were made in fractured freeze-dried cells. A dynamic distribution was observed from labeled arginine-treated LLC-PK{sub 1} kidney cells at mass 28 ({sup 13}C{sup 15}N) in negative secondaries, revealing cell-to-cell heterogeneity and preferential accumulation of the amino acid (or its metabolite) in the nucleus and nucleolus of some cells. The smaller nucleolus inside the nucleus was clearly resolved in SIMS images and confirmed by correlative light microscopy. The distribution of labeled phenylalanine contrasted with arginine as it was rather homogeneously distributed in T98G human glioblastoma cells. Images of {sup 39}K, {sup 23}Na and {sup 40}Ca were also recorded to confirm the reliability of sample preparation and authenticity of the observed amino acid distributions. These observations indicate that SIMS techniques can provide a valuable technology for subcellular localization of nitrogen-containing molecules in proteomics since nitrogen does not have a radionuclide tracer isotope. Amino acids labeled with stable isotopes can be used as tracers for studying their transport and metabolism in distinct subcellular compartments with SIMS. Further studies of phenylalanine uptake in human glioblastoma cells may have special significance in boron neutron capture therapy (BNCT) as a boron analogue of phenylalanine, boronophenylalanine is a clinically approved compound for the treatment of brain tumors.

Design Considerations for Multilingual Web Sites

Directory of Open Access Journals (Sweden)

Joan Starr

2005-09-01

Full Text Available The most powerful marketing, service, and information-distribution tool a library has today is its Web site, but providing Web content in many languages is complex. Before allocating scarce technical and financial resources, it is valuable to learn about writing systems, types of writing, how computers render and represent writing systems, and to study potential problem areas and their possible solutions. The accepted Web standard for presenting languages is Unicode and a full understanding of its history and the coding tools it provides is essential to making appropriate decisions for specific multilingual and internationalization projects. Actual coding examples, as well as a sampling of existing multilingual library services, also serve to illuminate the path of implementation.

web cellHTS2: A web-application for the analysis of high-throughput screening data

Directory of Open Access Journals (Sweden)

Boutros Michael

2010-04-01

Full Text Available Abstract Background The analysis of high-throughput screening data sets is an expanding field in bioinformatics. High-throughput screens by RNAi generate large primary data sets which need to be analyzed and annotated to identify relevant phenotypic hits. Large-scale RNAi screens are frequently used to identify novel factors that influence a broad range of cellular processes, including signaling pathway activity, cell proliferation, and host cell infection. Here, we present a web-based application utility for the end-to-end analysis of large cell-based screening experiments by cellHTS2. Results The software guides the user through the configuration steps that are required for the analysis of single or multi-channel experiments. The web-application provides options for various standardization and normalization methods, annotation of data sets and a comprehensive HTML report of the screening data analysis, including a ranked hit list. Sessions can be saved and restored for later re-analysis. The web frontend for the cellHTS2 R/Bioconductor package interacts with it through an R-server implementation that enables highly parallel analysis of screening data sets. web cellHTS2 further provides a file import and configuration module for common file formats. Conclusions The implemented web-application facilitates the analysis of high-throughput data sets and provides a user-friendly interface. web cellHTS2 is accessible online at http://web-cellHTS2.dkfz.de. A standalone version as a virtual appliance and source code for platforms supporting Java 1.5.0 can be downloaded from the web cellHTS2 page. web cellHTS2 is freely distributed under GPL.

World Wide Web voted most wonderful wonder by web-wide world

CERN Multimedia

2007-01-01

The results are in, and the winner is...the World Wide Web! An online survey conducted by the CNN news group ranks the World Wide Web-invented at CERN--as the most wonderful of the seven modern wonders of the world. (See Bulletin No. 49/2006.) There is currently no speculation about whether they would have had the same results had they distributed the survey by post. The World Wide Web won with a whopping 50 per cent of the votes (3,665 votes). The runner up was CERN again, with 16 per cent of voters (1130 votes) casting the ballot in favour of the CERN particle accelerator. Stepping into place behind CERN and CERN is 'None of the Above' with 8 per cent of the votes (611 votes), followed by the development of Dubai (7%), the bionic arm (7%), China's Three Gorges Damn (5%), The Channel Tunnel (4%), and France's Millau viaduct (3%). Thanks to everyone from CERN who voted. You can view the results on http://edition.cnn.com/SPECIALS/2006/modern.wonders/

In-111-oxine-labeled negative liposomes in tumor-bearing mice

International Nuclear Information System (INIS)

Chatal, J.F.; Guihard, D.; Bardy, A.; Pasqualini, R.

1983-01-01

The distribution of In-111-oxine-labelled liposomes in C 57 Bl 6 mice bearing a Lewis lung tumor and the variations contingent on modification of certain parameters have been studied. The distribution has been compared with that of Ga-67 citrate which is known for its affinity for lung tumors. In conclusion, it may be said that In-111-labeled negatively charged liposomes handled in oxygen-free conditions and having a size smaller than 80 nm make it possible to visualize a murine tumor as well, and even better, than does Ga-67 citrate

A method for automating the extraction of specialized information from the web

NARCIS (Netherlands)

Lin, L.; Liotta, A.; Hippisley, A.; Hao, Y.; Liu, J.; Wang, Y.; Cheung, Y-M.; Yin, H.; Jiao, L.; Ma, j.; Jiao, Y-C.

2005-01-01

The World Wide Web can be viewed as a gigantic distributed database including millions of interconnected hosts some of which publish information via web servers or peer-to-peer systems. We present here a novel method for the extraction of semantically rich information from the web in a fully

Nursing satisfaction and Web-based competencies.

Science.gov (United States)

McCarthy, Kathleen A; Kuhr, Monica; Buderer, Nancy

2010-01-01

This article describes the study of nursing satisfaction with Web-based learning and competency assignment given the learning management system (LMS) change from one LMS to another in 1 year. An anonymous paper-pencil survey was distributed to nursing staff after completing a year with two LMSs and prior to assigning Web-based competency requirements in the newer system (pre) and again after completing requirements (post). Nursing satisfaction and ease of use improved with assignment of requirements. Implications for staff development are described.

Quality of Web-based information on cocaine addiction.

Science.gov (United States)

Khazaal, Yasser; Chatton, Anne; Cochand, Sophie; Zullino, Daniele

2008-08-01

To evaluate the quality of web-based information on cocaine use and addiction and to investigate potential content quality indicators. Three keywords: cocaine, cocaine addiction and cocaine dependence were entered into two popular World Wide Web search engines. Websites were assessed with a standardized proforma designed to rate sites on the basis of accountability, presentation, interactivity, readability and content quality. "Health on the Net" (HON) quality label, and DISCERN scale scores aiding people without content expertise to assess quality of written health publication were used to verify their efficiency as quality indicators. Of the 120 websites identified, 61 were included. Most were commercial sites. The results of the study indicate low scores on each of the measures including content quality. A global score (the sum of accountability, interactivity, content quality and aesthetic criteria) appeared as a good content quality indicator. While cocaine education websites for patients are widespread, their global quality is poor. There is a need for better evidence-based information about cocaine use and addiction on the web. The poor and variable quality of web-based information and its possible impact on physician-patient relationship argue for a serious provider for patient talk about the health information found on Internet. Internet sites could improve their content using the global score as a quality indicator.

On the organ distribution of several 99mTc-labelled tetracyclines

International Nuclear Information System (INIS)

Weinhold, S.E.M.

1983-01-01

Experiments in rats have pointed to a high stability of 99m Tc-labelled tetracyclines, which are found in vivo in the form of chemically stable chelate complexes. Their biokinetic behaviour in most organs (the lungs) and the blood is predominantly determined by convection processes. In other organs (notably the kidneys and, to a lesser extent, the liver and spleen) their passage can be described in terms of influx and efflux, with accumulation, metabolisation and excretion of the drug administered being the main steps involved. 3 H-Labelled tetracyclines are chemically unchanged tetracyclines showing pronounced lipophilia that tend to be taken up and eliminated via influx and efflux processes in the large majority of organs. The highest blood levels were measured for 99m TcO 4 , which is a hydrophilic substance. None of the substances tested appeared to be able to cross the blood-brain barrier. As far as their chemical structure and solubility in water is concerned, 99m Tc-labelled tetracyclines occupy a position intermediate between the two comparative substances and the blood concentrations measured here were only moderately high. As they are accumulated to a considerable degree in the kidneys, the possibility of these substances' use in connection with renal scintiscans does not seem remote. In view of the fact that only one tenth of the dose of pertechnetate would be required for this purpose, radiation exposure could be reduced to a reasonable minimum. (TRV) [de

On the best learning algorithm for web services response time prediction

DEFF Research Database (Denmark)

Madsen, Henrik; Albu, Razvan-Daniel; Popentiu-Vladicescu, Florin

2013-01-01

In this article we will examine the effect of different learning algorithms, while training the MLP (Multilayer Perceptron) with the intention of predicting web services response time. Web services do not necessitate a user interface. This may seem contradictory to most people's concept of what...... an application is. A Web service is better imagined as an application "segment," or better as a program enabler. Performance is an important quality aspect of Web services because of their distributed nature. Predicting the response of web services during their operation is very important....

Standardized cardiovascular data for clinical research, registries, and patient care: a report from the Data Standards Workgroup of the National Cardiovascular Research Infrastructure project.

Science.gov (United States)

Anderson, H Vernon; Weintraub, William S; Radford, Martha J; Kremers, Mark S; Roe, Matthew T; Shaw, Richard E; Pinchotti, Dana M; Tcheng, James E

2013-05-07

Relatively little attention has been focused on standardization of data exchange in clinical research studies and patient care activities. Both are usually managed locally using separate and generally incompatible data systems at individual hospitals or clinics. In the past decade there have been nascent efforts to create data standards for clinical research and patient care data, and to some extent these are helpful in providing a degree of uniformity. Nonetheless, these data standards generally have not been converted into accepted computer-based language structures that could permit reliable data exchange across computer networks. The National Cardiovascular Research Infrastructure (NCRI) project was initiated with a major objective of creating a model framework for standard data exchange in all clinical research, clinical registry, and patient care environments, including all electronic health records. The goal is complete syntactic and semantic interoperability. A Data Standards Workgroup was established to create or identify and then harmonize clinical definitions for a base set of standardized cardiovascular data elements that could be used in this network infrastructure. Recognizing the need for continuity with prior efforts, the Workgroup examined existing data standards sources. A basic set of 353 elements was selected. The NCRI staff then collaborated with the 2 major technical standards organizations in health care, the Clinical Data Interchange Standards Consortium and Health Level Seven International, as well as with staff from the National Cancer Institute Enterprise Vocabulary Services. Modeling and mapping were performed to represent (instantiate) the data elements in appropriate technical computer language structures for endorsement as an accepted data standard for public access and use. Fully implemented, these elements will facilitate clinical research, registry reporting, administrative reporting and regulatory compliance, and patient care

Web components and the semantic web

OpenAIRE

Casey, Maire; Pahl, Claus

2003-01-01

Component-based software engineering on the Web differs from traditional component and software engineering. We investigate Web component engineering activites that are crucial for the development,com position, and deployment of components on the Web. The current Web Services and Semantic Web initiatives strongly influence our work. Focussing on Web component composition we develop description and reasoning techniques that support a component developer in the composition activities,fo cussing...

Sistem Informasi Manajemen Terpadu Tanggap Darurat Bencana Berbasis Web

Directory of Open Access Journals (Sweden)

Isnardi ,

2015-07-01

Full Text Available A series ofdisasters in Indonesia has caused the deaths ofthousands and even hundreds of lives as the tsunami in Aceh and Nias, and the recent earthquake in West Sumatra Padang region.In such situations, the information about the list of needs and distribution of aid is desperately needed by the whole community. Through these research activities is expected that the information is expected to be available are up to date in order to reach an aid distribution system more efficient and effective, especially shortly after the disaster.With the title of research Integrated Management Information System Web-Based Disaster Response, then have some information may be presented as (a. The impact of disasters in specific regions over the web is visually displayed in the form of pictures or photos, videos and maps of (b. Sign up for urgent basic needs of disaster victims in any disaster (c. The amount of aid available at the disaster relief center, and (d. The amount of aid that has been distributed to the affected area and (d. The data and the number ofvictims affected in each area.In the course of this research, produced a web site that acts as an information center for emergency response that is able to accommodate all of the information society will kind of help is needed and the amount of aid that has been successfully distributed to prevent the buildup of assistance in certain areas dehingga be equitable distribution ofaid to all areas affected the disaster.Keyword: Disaster, Web, System, Distribution, Help Rentetan bencana di Indonesia telah banyak menyebabkan terjadinya korban jiwa bahkan hingga ratusan ribu nyawa seperti bencana tsunami di Aceh ien Nias, dan terakhir gempa bumi dahsyat di wilayah Padang Sumatera Barat.Dalam situasi tersebut, informasi tentang daftar kebutuhan sertapendistribusian bantuan merupakan hal yang sangat dibutuhkan oleh seluruh masyarakat. Melalui kegiatan penelitian ini diharapkan agar informasi yang sangat diharapkan

Synthesis and pharmacokinetics of thiacoccide labeled with tritium

International Nuclear Information System (INIS)

Shestakov, A.D.; Kaminskii, Yu.L.; Nurova, I.M.; Nikitina, V.N.; Zaionts, V.I.; Maksimova, O.V.; Mikhailov, G.A.

1986-01-01

To obtain information on the pharmacokinetics of thiacoccide, the authors effect the synthesis of an analog of thiacoccide, viz., the hydrochloride of 2-methyl-N-(2'-n-propyl-4'-aminopyrimid-5'-ylmethyl)pyridinium chloride (I) labeled with tritium. The simplest way to introduce a tritium label into (I) is by isotopic exchange of hydrogen of (I) with H 3 HO. Typical material obtained from isotopic exchange with water labeled with tritium is shown. The dynamics of 3 H distribution in the organism of the chick and the rate of its elimination on single administration of thiacoccide containing isotope in both the methyl group and in the pyridine ring are shown

Quality control of technetium-labelled lung imaging agents

International Nuclear Information System (INIS)

Chervu, L.R.; Vallabhajosula, S.R.; Blaufox, M.D.

1977-01-01

A study has been made of the labelling of macroaggregated albumin particles (MAA) with sup(99m)Tc using three commercial kits, and the results compared with those obtained with albumin microspheres. The tagging efficiency was measured by three different methods, and the chemistry and radiochemical nature of the sup(99m)Tc-MAA supernates or eluates were also investigated. The total body distribution of the sup(99m)Tc-MAA supernates was determined in mice after tail-vein injection. The results indicated that technetium-labelled MAA preparations may contain sup(99m)Tc-tagged albumin, similar to human serum albumin in solution. The nature of labelling pattern of MAA and the albumin microspheres indicated that the macroaggregates and microspheres were not completely or uniformly labelled during a one-step addition of pertechnetate. The lung aggregates had a large residual labelling capacity. Consideration is given to the significance of these results in lung perfusion studies. (U.K.)

Selection of well labelled insulin fractions for radioimmunoassay use

Energy Technology Data Exchange (ETDEWEB)

Awh, O D; Kim, J R [Korea Atomic Energy Research Inst., Seoul (Republic of Korea)

1980-06-01

Selection methods of well labelled insulin fractions based on two different criteria were compared to establish an efficient low level RIA of insulin and to elucidate the correlation between the immunoreactivity and the charcoal-adsorptivity of the radioiodine labelled insulin. The result indicated that the selection of well labelled insulin fractions by means of a charcoal-adsorption test is inappropriate. Generally, the distribution of radioactivity, antibody-bindability, and charcoal-adsorptivity of the labelled insulin was not consistent with each other. Thus, the selection should be carried out for every labelling batch to get the utmost assay reliability by antibody-bindability but not by charcoal-adsorptivity. By using the well selected labelled insulin fractions based on antibody-binding, a correct assay for a reference serum was possible, and by extending the incubation time up to 96 hrs, a sharp dose response curve could be obtained even in the range of below 5 ..mu..U/ml standard insulin doses.

21 CFR 203.38 - Sample lot or control numbers; labeling of sample units.

Science.gov (United States)

2010-04-01

... numbers; labeling of sample units. (a) Lot or control number required on drug sample labeling and sample... identifying lot or control number that will permit the tracking of the distribution of each drug sample unit... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Sample lot or control numbers; labeling of sample...

SSWAP: A Simple Semantic Web Architecture and Protocol for semantic web services.

Science.gov (United States)

Gessler, Damian D G; Schiltz, Gary S; May, Greg D; Avraham, Shulamit; Town, Christopher D; Grant, David; Nelson, Rex T

2009-09-23

SSWAP (Simple Semantic Web Architecture and Protocol; pronounced "swap") is an architecture, protocol, and platform for using reasoning to semantically integrate heterogeneous disparate data and services on the web. SSWAP was developed as a hybrid semantic web services technology to overcome limitations found in both pure web service technologies and pure semantic web technologies. There are currently over 2400 resources published in SSWAP. Approximately two dozen are custom-written services for QTL (Quantitative Trait Loci) and mapping data for legumes and grasses (grains). The remaining are wrappers to Nucleic Acids Research Database and Web Server entries. As an architecture, SSWAP establishes how clients (users of data, services, and ontologies), providers (suppliers of data, services, and ontologies), and discovery servers (semantic search engines) interact to allow for the description, querying, discovery, invocation, and response of semantic web services. As a protocol, SSWAP provides the vocabulary and semantics to allow clients, providers, and discovery servers to engage in semantic web services. The protocol is based on the W3C-sanctioned first-order description logic language OWL DL. As an open source platform, a discovery server running at http://sswap.info (as in to "swap info") uses the description logic reasoner Pellet to integrate semantic resources. The platform hosts an interactive guide to the protocol at http://sswap.info/protocol.jsp, developer tools at http://sswap.info/developer.jsp, and a portal to third-party ontologies at http://sswapmeet.sswap.info (a "swap meet"). SSWAP addresses the three basic requirements of a semantic web services architecture (i.e., a common syntax, shared semantic, and semantic discovery) while addressing three technology limitations common in distributed service systems: i.e., i) the fatal mutability of traditional interfaces, ii) the rigidity and fragility of static subsumption hierarchies, and iii) the

Analysis of Technique to Extract Data from the Web for Improved Performance

Science.gov (United States)

Gupta, Neena; Singh, Manish

2010-11-01

The World Wide Web rapidly guides the world into a newly amazing electronic world, where everyone can publish anything in electronic form and extract almost all the information. Extraction of information from semi structured or unstructured documents, such as web pages, is a useful yet complex task. Data extraction, which is important for many applications, extracts the records from the HTML files automatically. Ontologies can achieve a high degree of accuracy in data extraction. We analyze method for data extraction OBDE (Ontology-Based Data Extraction), which automatically extracts the query result records from the web with the help of agents. OBDE first constructs an ontology for a domain according to information matching between the query interfaces and query result pages from different web sites within the same domain. Then, the constructed domain ontology is used during data extraction to identify the query result section in a query result page and to align and label the data values in the extracted records. The ontology-assisted data extraction method is fully automatic and overcomes many of the deficiencies of current automatic data extraction methods.

CMS offline web tools

International Nuclear Information System (INIS)

Metson, S; Newbold, D; Belforte, S; Kavka, C; Bockelman, B; Dziedziniewicz, K; Egeland, R; Elmer, P; Eulisse, G; Tuura, L; Evans, D; Fanfani, A; Feichtinger, D; Kuznetsov, V; Lingen, F van; Wakefield, S

2008-01-01

We describe a relatively new effort within CMS to converge on a set of web based tools, using state of the art industry techniques, to engage with the CMS offline computing system. CMS collaborators require tools to monitor various components of the computing system and interact with the system itself. The current state of the various CMS web tools is described along side current planned developments. The CMS collaboration comprises of nearly 3000 people from all over the world. As well as its collaborators, its computing resources are spread all over globe and are accessed via the LHC grid to run analysis, large scale production and data transfer tasks. Due to the distributed nature of collaborators effective provision of collaborative tools is essential to maximise physics exploitation of the CMS experiment, especially when the size of the CMS data set is considered. CMS has chosen to provide such tools over the world wide web as a top level service, enabling all members of the collaboration to interact with the various offline computing components. Traditionally web interfaces have been added in HEP experiments as an afterthought. In the CMS offline we have decided to put web interfaces, and the development of a common CMS web framework, on an equal footing with the rest of the offline development. Tools exist within CMS to transfer and catalogue data (PhEDEx and DBS/DLS), run Monte Carlo production (ProdAgent) and submit analysis (CRAB). Effective human interfaces to these systems are required for users with different agendas and practical knowledge of the systems to effectively use the CMS computing system. The CMS web tools project aims to provide a consistent interface to all these tools

CMS offline web tools

Energy Technology Data Exchange (ETDEWEB)

Metson, S; Newbold, D [H.H. Wills Physics Laboratory, University of Bristol, Tyndall Avenue, Bristol BS8 1TL (United Kingdom); Belforte, S; Kavka, C [INFN, Sezione di Trieste (Italy); Bockelman, B [University of Nebraska Lincoln, Lincoln, NE (United States); Dziedziniewicz, K [CERN, Geneva (Switzerland); Egeland, R [University of Minnesota Twin Cities, Minneapolis, MN (United States); Elmer, P [Princeton (United States); Eulisse, G; Tuura, L [Northeastern University, Boston, MA (United States); Evans, D [Fermilab MS234, Batavia, IL (United States); Fanfani, A [Universita degli Studi di Bologna (Italy); Feichtinger, D [PSI, Villigen (Switzerland); Kuznetsov, V [Cornell University, Ithaca, NY (United States); Lingen, F van [California Institute of Technology, Pasedena, CA (United States); Wakefield, S [Blackett Laboratory, Imperial College, London (United Kingdom)

2008-07-15

We describe a relatively new effort within CMS to converge on a set of web based tools, using state of the art industry techniques, to engage with the CMS offline computing system. CMS collaborators require tools to monitor various components of the computing system and interact with the system itself. The current state of the various CMS web tools is described along side current planned developments. The CMS collaboration comprises of nearly 3000 people from all over the world. As well as its collaborators, its computing resources are spread all over globe and are accessed via the LHC grid to run analysis, large scale production and data transfer tasks. Due to the distributed nature of collaborators effective provision of collaborative tools is essential to maximise physics exploitation of the CMS experiment, especially when the size of the CMS data set is considered. CMS has chosen to provide such tools over the world wide web as a top level service, enabling all members of the collaboration to interact with the various offline computing components. Traditionally web interfaces have been added in HEP experiments as an afterthought. In the CMS offline we have decided to put web interfaces, and the development of a common CMS web framework, on an equal footing with the rest of the offline development. Tools exist within CMS to transfer and catalogue data (PhEDEx and DBS/DLS), run Monte Carlo production (ProdAgent) and submit analysis (CRAB). Effective human interfaces to these systems are required for users with different agendas and practical knowledge of the systems to effectively use the CMS computing system. The CMS web tools project aims to provide a consistent interface to all these tools.

Tracing the cosmic web

Science.gov (United States)

Libeskind, Noam I.; van de Weygaert, Rien; Cautun, Marius; Falck, Bridget; Tempel, Elmo; Abel, Tom; Alpaslan, Mehmet; Aragón-Calvo, Miguel A.; Forero-Romero, Jaime E.; Gonzalez, Roberto; Gottlöber, Stefan; Hahn, Oliver; Hellwing, Wojciech A.; Hoffman, Yehuda; Jones, Bernard J. T.; Kitaura, Francisco; Knebe, Alexander; Manti, Serena; Neyrinck, Mark; Nuza, Sebastián E.; Padilla, Nelson; Platen, Erwin; Ramachandra, Nesar; Robotham, Aaron; Saar, Enn; Shandarin, Sergei; Steinmetz, Matthias; Stoica, Radu S.; Sousbie, Thierry; Yepes, Gustavo

2018-01-01

The cosmic web is one of the most striking features of the distribution of galaxies and dark matter on the largest scales in the Universe. It is composed of dense regions packed full of galaxies, long filamentary bridges, flattened sheets and vast low-density voids. The study of the cosmic web has focused primarily on the identification of such features, and on understanding the environmental effects on galaxy formation and halo assembly. As such, a variety of different methods have been devised to classify the cosmic web - depending on the data at hand, be it numerical simulations, large sky surveys or other. In this paper, we bring 12 of these methods together and apply them to the same data set in order to understand how they compare. In general, these cosmic-web classifiers have been designed with different cosmological goals in mind, and to study different questions. Therefore, one would not a priori expect agreement between different techniques; however, many of these methods do converge on the identification of specific features. In this paper, we study the agreements and disparities of the different methods. For example, each method finds that knots inhabit higher density regions than filaments, etc. and that voids have the lowest densities. For a given web environment, we find a substantial overlap in the density range assigned by each web classification scheme. We also compare classifications on a halo-by-halo basis; for example, we find that 9 of 12 methods classify around a third of group-mass haloes (i.e. Mhalo ∼ 1013.5 h-1 M⊙) as being in filaments. Lastly, so that any future cosmic-web classification scheme can be compared to the 12 methods used here, we have made all the data used in this paper public.

Automated characterization of nerve fibers labeled fluorescently: determination of size, class and spatial distribution.

Science.gov (United States)

Prodanov, Dimiter; Feirabend, Hans K P

2008-10-03

Morphological classification of nerve fibers could help interpret the assessment of neural regeneration and the understanding of selectivity of nerve stimulation. Specific populations of myelinated nerve fibers can be investigated by retrograde tracing from a muscle followed by microscopic measurements of the labeled fibers at different anatomical levels. Gastrocnemius muscles of adult rats were injected with the retrograde tracer Fluoro-Gold. After a survival period of 3 days, cross-sections of spinal cords, ventral roots, sciatic, and tibial nerves were collected and imaged on a fluorescence microscope. Nerve fibers were classified using a variation-based criterion acting on the distribution of their equivalent diameters. The same criterion was used to classify the labeled axons using the size of the fluorescent marker. Measurements of the axons were paired to those of the entire fibers (axons+myelin sheaths) in order to establish the correspondence between so-established axonal and fiber classifications. It was found that nerve fibers in L6 ventral roots could be classified into four populations comprising two classes of Aalpha (denoted Aalpha1 and Aalpha2), Agamma, and an additional class of Agammaalpha fibers. Cut-off borders between Agamma and Agammaalpha fiber classes were estimated to be 5.00+/-0.09 microm (SEM); between Agammaalpha and Aalpha1 fiber classes to be 6.86+/-0.11 microm (SEM); and between Aalpha1 and Aalpha2 fiber classes to be 8.66+/-0.16 microm (SEM). Topographical maps of the nerve fibers that innervate the gastrocnemius muscles were constructed per fiber class for the spinal root L6. The major advantage of the presented approach consists of the combined indirect classification of nerve fiber types and the construction of topographical maps of so-identified fiber classes.

Labelling of leucocytes with colloidal technetium-99m-SnF2: an investigation of the labelling process by autoradiography

International Nuclear Information System (INIS)

Puncher, M.R.B.; Blower, P.J.

1995-01-01

Autoradiography of smears and frozen sections of labelled cell suspensions was used to study the distribution of radioactivity in and among blood cells labelled in either whole blood or leucocyte-rich plasma (LRP) with technetium-99m-SnF 2 colloid. The tracer proved selective for neutrophils: the labelling probability (relative to that for erythrocytes) for each cell type in LRP (mean of five samples) was: neutrophils, 9.4; lymphocytes, 3.7; monocytes, 3.0; eosinophils 1.4; erythrocytes, 1.0. When labelling was carried out in whole blood (five samples), 74.5%±8.3% of the cell-bound radioactivity was bound to erythrocytes, 13.6%±6.5% to neutrophils, and 11.9%±2.1% to lymphocytes, whereas in LRP (in which the leucocytes were only slightly outnumbered by erythrocytes), 76.5%±14.9% of radioactivity was neutrophil bound. Labelled cells in smear autoradiographs exhibited two distinct silver grain patterns, ''diffuse'', consistent with an intracellular radioactive particle (in neutrophils), and ''focal'', consistent with a cell surface-adhering particle in direct contact with the emulsion (in other leucocyte types and erythrocytes). The phagocytic inhibitor cytochalasin B neither reduced the proportion of labelled neutrophils nor altered the labelling pattern. Neutrophils were able to scavenge radioactivity from the surface of erythrocytes. It is concluded that neutrophils bind 99m Tc-SnF 2 intracellularly by phagocytosis, with high affinity; other cells become labelled at the cell surface reversibly and with lower affinity. This selectivity is high enough to permit predominantly leucocyte labelling in LRP but not in whole blood. (orig.)

WebVis: a hierarchical web homepage visualizer

Science.gov (United States)

Renteria, Jose C.; Lodha, Suresh K.

2000-02-01

WebVis, the Hierarchical Web Home Page Visualizer, is a tool for managing home web pages. The user can access this tool via the WWW and obtain a hierarchical visualization of one's home web pages. WebVis is a real time interactive tool that supports many different queries on the statistics of internal files such as sizes, age, and type. In addition, statistics on embedded information such as VRML files, Java applets, images and sound files can be extracted and queried. Results of these queries are visualized using color, shape and size of different nodes of the hierarchy. The visualization assists the user in a variety of task, such as quickly finding outdated information or locate large files. WebVIs is one solution to the growing web space maintenance problem. Implementation of WebVis is realized with Perl and Java. Perl pattern matching and file handling routines are used to collect and process web space linkage information and web document information. Java utilizes the collected information to produce visualization of the web space. Java also provides WebVis with real time interactivity, while running off the WWW. Some WebVis examples of home web page visualization are presented.

Comparing Web Applications with Desktop Applications: An Empirical Study

DEFF Research Database (Denmark)

Pop, Paul

2002-01-01

In recent years, many desktop applications have been ported to the world wide web in order to reduce (multiplatform) development, distribution and maintenance costs. However, there is little data concerning the usability of web applications, and the impact of their usability on the total cost...... of developing and using such applications. In this paper we present a comparison of web and desktop applications from the usability point of view. The comparison is based on an empirical study that investigates the performance of a group of users on two calendaring applications: Yahoo!Calendar and Microsoft...... Calendar. The study shows that in the case of web applications the performance of the users is significantly reduced, mainly because of the restricted interaction mechanisms provided by current web browsers....

Analysis of Trust-Based Approaches for Web Service Selection

DEFF Research Database (Denmark)

Dragoni, Nicola; Miotto, Nicola

2011-01-01

The basic tenet of Service-Oriented Computing (SOC) is the possibility of building distributed applications on the Web by using Web services as fundamental building blocks. The proliferation of such services is considered the second wave of evolution in the Internet age, moving the Web from...... a collection of pages to a collections of services. Consensus is growing that this Web service revolution wont eventuate until we resolve trust-related issues. Indeed, the intrinsic openness of the SOC vision makes crucial to locate useful services and recognize them as trustworthy. In this paper we review...... the field of trust-based Web service selection, providing a structured classification of current approaches and highlighting the main limitations of each class and of the overall field....

Indium-111 labeling of leukocytes: a detrimental effect on neutrophil and lymphocyte function and an improved method of cell labelling

International Nuclear Information System (INIS)

Segal, A.W.; Deteix, P.; Garcia, R.; Tooth, P.; Zanelli, G.D.; Allison, A.C.

1978-01-01

A technique for the labeling of cells with the gamma emitter indium-111 has recently been developed. In this study the effects of the labeling procedure on some in vitro functions of human neutrophils and lymphocytes were investigated. With the standard labeling procedure, neutrophil chemotaxis was reduced to approximately 50% of normal and lymphocytes lost surface receptors and failed to respond to stimulation with phytohemagglutinin. The 8-hydroxyquinoline that is used to chelate the indium is toxic to lymphocytes; accordingly the relationship between the quantity of oxine, the chelation of indium, and cell labeling were investigated. Optimal conditions for In-111 cell labeling were established: 100 million cells in 10 ml Hanks' balanced salt solution are mixed with 5 μg of oxine in a mixture of 50 μl of ethanol and 200 μl of saline; they are incubated at 37 0 C for 10 min and then washed. Initially, neutrophils and lymphocytes appear functionally normal, but after 24 to 48 hr lymphocyte function is impaired as a result of radiation damage. This toxicity may limit studies by external scanning on the distribution and kinetics of lymphocytes labeled with In-111

AUC-Maximized Deep Convolutional Neural Fields for Protein Sequence Labeling.

Science.gov (United States)

Wang, Sheng; Sun, Siqi; Xu, Jinbo

2016-09-01

Deep Convolutional Neural Networks (DCNN) has shown excellent performance in a variety of machine learning tasks. This paper presents Deep Convolutional Neural Fields (DeepCNF), an integration of DCNN with Conditional Random Field (CRF), for sequence labeling with an imbalanced label distribution. The widely-used training methods, such as maximum-likelihood and maximum labelwise accuracy, do not work well on imbalanced data. To handle this, we present a new training algorithm called maximum-AUC for DeepCNF. That is, we train DeepCNF by directly maximizing the empirical Area Under the ROC Curve (AUC), which is an unbiased measurement for imbalanced data. To fulfill this, we formulate AUC in a pairwise ranking framework, approximate it by a polynomial function and then apply a gradient-based procedure to optimize it. Our experimental results confirm that maximum-AUC greatly outperforms the other two training methods on 8-state secondary structure prediction and disorder prediction since their label distributions are highly imbalanced and also has similar performance as the other two training methods on solvent accessibility prediction, which has three equally-distributed labels. Furthermore, our experimental results show that our AUC-trained DeepCNF models greatly outperform existing popular predictors of these three tasks. The data and software related to this paper are available at https://github.com/realbigws/DeepCNF_AUC.

An Open Source Software and Web-GIS Based Platform for Airborne SAR Remote Sensing Data Management, Distribution and Sharing

Science.gov (United States)

Changyong, Dou; Huadong, Guo; Chunming, Han; Ming, Liu

2014-03-01

With more and more Earth observation data available to the community, how to manage and sharing these valuable remote sensing datasets is becoming an urgent issue to be solved. The web based Geographical Information Systems (GIS) technology provides a convenient way for the users in different locations to share and make use of the same dataset. In order to efficiently use the airborne Synthetic Aperture Radar (SAR) remote sensing data acquired in the Airborne Remote Sensing Center of the Institute of Remote Sensing and Digital Earth (RADI), Chinese Academy of Sciences (CAS), a Web-GIS based platform for airborne SAR data management, distribution and sharing was designed and developed. The major features of the system include map based navigation search interface, full resolution imagery shown overlaid the map, and all the software adopted in the platform are Open Source Software (OSS). The functions of the platform include browsing the imagery on the map navigation based interface, ordering and downloading data online, image dataset and user management, etc. At present, the system is under testing in RADI and will come to regular operation soon.

Palmitic acid-labeled lipids selectively incorporated into platelet cytoskeleton during aggregation

International Nuclear Information System (INIS)

Packham, M.A.; Guccione, M.A.; Bryant, N.L.; Livne, A.

1990-01-01

Previous experiments showed that during the early stages (20-30 seconds) of aggregation induced by adenosine diphosphate (ADP, 2 microM) or thrombin (0.1 U/mL) of rabbit or human platelets prelabeled with [3H]palmitic acid, labeled lipid became associated with the cytoskeleton isolated after lysis with 1% Triton X-100, 5 mM EGTA [ethylene glycol-bis-(beta-aminoethyl ether)]-N,N,N',N'-tetra-acetic acid. The association appeared to be related to the number of sites of contact and was independent of the release of granule contents. We have now investigated the nature of the labeled lipids by thin-layer and column chromatography and found differences between the distribution of the label in intact platelets (both stimulated and unstimulated) and the isolated cytoskeletons. In both species, and with either ADP or thrombin as aggregating agent, 70-85% of the label in both intact platelets and in the cytoskeletons was in phospholipids. The distribution of label among the phospholipids in the cytoskeletons was similar to that in intact platelets except that the percentage of label in phosphatidylcholine was significantly higher in the cytoskeletons of human platelets than in the intact platelets, and the percentage of label in phosphatidylserine/phosphatidylinositol was significantly lower in the cytoskeletons of rabbit platelets and thrombin-aggregated human platelets than in intact platelets. The cytoskeletons contained a lower percentage of label in triacylglycerol, diacylglycerol, and cholesterol ester than the intact platelets. Contrary to a report in the literature, we found no evidence for the incorporation of diacylglycerol and palmitic acid into the cytoskeleton

Role of Librarian in Internet and World Wide Web Environment

OpenAIRE

K. Nageswara Rao; KH Babu

2001-01-01

The transition of traditional library collections to digital or virtual collections presented the librarian with new opportunities. The Internet, Web en-vironment and associated sophisticated tools have given the librarian a new dynamic role to play and serve the new information based society in bet-ter ways than hitherto. Because of the powerful features of Web i.e. distributed, heterogeneous, collaborative, multimedia, multi-protocol, hyperme-dia-oriented architecture, World Wide Web has re...

BioconductorBuntu: a Linux distribution that implements a web-based DNA microarray analysis server.

Science.gov (United States)

Geeleher, Paul; Morris, Dermot; Hinde, John P; Golden, Aaron

2009-06-01

BioconductorBuntu is a custom distribution of Ubuntu Linux that automatically installs a server-side microarray processing environment, providing a user-friendly web-based GUI to many of the tools developed by the Bioconductor Project, accessible locally or across a network. System installation is via booting off a CD image or by using a Debian package provided to upgrade an existing Ubuntu installation. In its current version, several microarray analysis pipelines are supported including oligonucleotide, dual-or single-dye experiments, including post-processing with Gene Set Enrichment Analysis. BioconductorBuntu is designed to be extensible, by server-side integration of further relevant Bioconductor modules as required, facilitated by its straightforward underlying Python-based infrastructure. BioconductorBuntu offers an ideal environment for the development of processing procedures to facilitate the analysis of next-generation sequencing datasets. BioconductorBuntu is available for download under a creative commons license along with additional documentation and a tutorial from (http://bioinf.nuigalway.ie).

Open Hypermedia as User Controlled Meta Data for the Web

DEFF Research Database (Denmark)

Grønbæk, Kaj; Sloth, Lennert; Bouvin, Niels Olof

2000-01-01

segments. By means of the Webvise system, OHIF structures can be authored, imposed on Web pages, and finally linked on the Web as any ordinary Web resource. Following a link to an OHIF file automatically invokes a Webvise download of the meta data structures and the annotated Web content will be displayed...... in the browser. Moreover, the Webvise system provides support for users to create, manipulate, and share the OHIF structures together with custom made web pages and MS Office 2000 documents on WebDAV servers. These Webvise facilities goes beyond ealier open hypermedia systems in that it now allows fully...... distributed open hypermedia linking between Web pages and WebDAV aware desktop applications. The paper describes the OHIF format and demonstrates how the Webvise system handles OHIF. Finally, it argues for better support for handling user controlled meta data, e.g. support for linking in non-XML data...

Off the Beaten tracks: Exploring Three Aspects of Web Navigation

NARCIS (Netherlands)

Weinreich, H.; Obendorf, H.; Herder, E.; Mayer, M.; Edmonds, H.; Hawkey, K.; Kellar, M.; Turnbull, D.

2006-01-01

This paper presents results of a long-term client-side Web usage study, updating previous studies that range in age from five to ten years. We focus on three aspects of Web navigation: changes in the distribution of navigation actions, speed of navigation and within-page navigation. “Navigation

Tissue distribution and tumour localization of 99m-technetium-labelled liposomes in cancer patients

Energy Technology Data Exchange (ETDEWEB)

Richardson, V J; Ryman, B E; Jewkes, R F; Jeyasingh, K; Tattersall, M N.H.; Newlands, E S; Kaye, S B

1979-07-01

The possible use of liposomes (Phospholipid vesicles) to direct cytotoxic drugs to tumours led to the investigation of the tissue localization of i.v. injected sup(99m) Tc-labelled liposomes in cancer patients. 20 mg or 300 mg doses of liposomal lipid (7:2:1 molar ratio of phosphatidylcholine: cholesterol: phosphatidic acid) were used in a study of 13 patients with advanced cancer and one with polycythaemia rubra vera (PRV). In all cases except the patient with PRV the major site of uptake of the label was the liver and spleen. In the patient with PRV the liver uptake was greatly reduced and the major site of uptake was found in regions corresponding to marrow. With the exception of one patient with a primary hepatoma, there was no significant tumour uptake of the label.

Isotopically labelled benzodiazepines

International Nuclear Information System (INIS)

Liebman, A.A.

1987-01-01

This paper reports on the benzodiazepines which are a class of therapeutic agents. Improvements in the analytical methodology in the areas of biochemistry and pharmacology were significant, particularly in the application of chromatographic and spectroscopic techniques. In addition, the discovery and subsequent development of tritium and carbon-14 as an analytical tool in the biological sciences were essentially post-world war II phenomena. Thus, as these new chemical entities were found to be biologically active, they could be prepared in labeled form for metabolic study, biological half-life determination (pharmacokinetics), tissue distribution study, etc. This use of tracer methodology has been liberally applied to the benzodiazepines and also more recently to the study of receptor-ligand interactions, in which tritium, carbon-11 or fluorine-18 isotopes have been used. The history of benzodiazepines as medicinal agents is indeed an interesting one; an integral part of that history is their use in just about every conceivable labeled form

Integrating thematic web portal capabilities into the NASA Earthdata Web Infrastructure

Science.gov (United States)

Wong, M. M.; McLaughlin, B. D.; Huang, T.; Baynes, K.

2015-12-01

The National Aeronautics and Space Administration (NASA) acquires and distributes an abundance of Earth science data on a daily basis to a diverse user community worldwide. To assist the scientific community and general public in achieving a greater understanding of the interdisciplinary nature of Earth science and of key environmental and climate change topics, the NASA Earthdata web infrastructure is integrating new methods of presenting and providing access to Earth science information, data, research and results. This poster will present the process of integrating thematic web portal capabilities into the NASA Earthdata web infrastructure, with examples from the Sea Level Change Portal. The Sea Level Change Portal will be a source of current NASA research, data and information regarding sea level change. The portal will provide sea level change information through articles, graphics, videos and animations, an interactive tool to view and access sea level change data and a dashboard showing sea level change indicators. Earthdata is a part of the Earth Observing System Data and Information System (EOSDIS) project. EOSDIS is a key core capability in NASA's Earth Science Data Systems Program. It provides end-to-end capabilities for managing NASA's Earth science data from various sources - satellites, aircraft, field measurements, and various other programs. It is comprised of twelve Distributed Active Archive Centers (DAACs), Science Computing Facilities (SCFs), data discovery and service access client (Reverb and Earthdata Search), dataset directory (Global Change Master Directory - GCMD), near real-time data (Land Atmosphere Near real-time Capability for EOS - LANCE), Worldview (an imagery visualization interface), Global Imagery Browse Services, the Earthdata Code Collaborative and a host of other discipline specific data discovery, data access, data subsetting and visualization tools.

Direct isotope determination of isotopically labelled lipids by field desorption mass spectrometry

International Nuclear Information System (INIS)

Lehmann, W.D.; Kessler, M.

1982-01-01

Lipids labelled with deuterium or carbon-14 have been investigated by field desorption mass spectrometry for determination of their degree of labelling. This application is demonstrated for free fatty acids, cholesterol, cholesteryl esters, triglycerides, and L-α-phosphatidylcholines. Comparison of the molecular ion groups of the non-labelled and of the labelled compounds enables a fast and reliable determination of the degree of labelling. For multiply labelled compounds the label distribution is also obtained from the molecular ion group. In addition, for cholesteryl esters and for phosphatidylcholines structurally significant fragment ions provide information about the position of the label. Several hundred nanograms of the compound are typically required for a single analysis with a relative standard error of 0.5-2% in the value calculated for atom% hydrogen-2 or for the specific carbon-14 activity. (orig.) [de

VisPortal: Deploying grid-enabled visualization tools through a web-portal interface

Energy Technology Data Exchange (ETDEWEB)

Bethel, Wes; Siegerist, Cristina; Shalf, John; Shetty, Praveenkumar; Jankun-Kelly, T.J.; Kreylos, Oliver; Ma, Kwan-Liu

2003-06-09

The LBNL/NERSC Visportal effort explores ways to deliver advanced Remote/Distributed Visualization (RDV) capabilities through a Grid-enabled web-portal interface. The effort focuses on latency tolerant distributed visualization algorithms, GUI designs that are more appropriate for the capabilities of web interfaces, and refactoring parallel-distributed applications to work in a N-tiered component deployment strategy. Most importantly, our aim is to leverage commercially-supported technology as much as possible in order to create a deployable, supportable, and hence viable platform for delivering grid-based visualization services to collaboratory users.

The Uniframe .Net Web Service Discovery Service

National Research Council Canada - National Science Library

Berbeco, Robert W

2003-01-01

Microsoft .NET allows the creation of distributed systems in a seamless manner Within NET small, discrete applications, referred to as Web services, are utilized to connect to each other or larger applications...

Eco-Labeled Seafood: Determinants for (Blue Green Consumption

Directory of Open Access Journals (Sweden)

Malin Jonell

2016-09-01

Full Text Available Eco-certification has become an increasingly popular market-based tool in the endeavor to reduce negative environmental impacts from fisheries and aquaculture. In this study, we aimed at investigating which psychological consumer characteristics influence demand for eco-labeled seafood by correlating consumers’ stated purchasing of eco-labeled seafood to nine variables: environmental knowledge regarding seafood production, familiarity with eco-labels, subjective knowledge, pro-environmental self-identification, sense of personal responsibility, concern for negative environmental impacts from seafood production, perceived consumer effectiveness, gender and education. Questionnaires were distributed to consumers in Stockholm, Sweden, and the data were tested with multiple regression analysis using linear modeling and model averaging (n = 371. Two variables were the best predictors of stated purchasing of eco-labeled seafood: (i recognition and understanding of eco-labels for seafood (Marine Stewardship Council, Fish for Life, Aquaculture Stewardship Council and KRAV; and (ii concern for negative environmental impacts associated with seafood production. Meanwhile, consumer environmental knowledge was a weaker predictor. Results from this study suggest that strengthening the emotional component of consumer decision-making and improving the level of consumer familiarity with seafood eco-labels could stimulate more pro-environmental seafood consumption.

Web-based control application using WebSocket

International Nuclear Information System (INIS)

Furukawa, Y.

2012-01-01

The WebSocket allows asynchronous full-duplex communication between a Web-based (i.e. Java Script-based) application and a Web-server. WebSocket started as a part of HTML5 standardization but has now been separated from HTML5 and has been developed independently. Using WebSocket, it becomes easy to develop platform independent presentation layer applications for accelerator and beamline control software. In addition, a Web browser is the only application program that needs to be installed on client computer. The WebSocket-based applications communicate with the WebSocket server using simple text-based messages, so WebSocket is applicable message-based control system like MADOCA, which was developed for the SPring-8 control system. A simple WebSocket server for the MADOCA control system and a simple motor control application were successfully made as a first trial of the WebSocket control application. Using Google-Chrome (version 13.0) on Debian/Linux and Windows 7, Opera (version 11.0) on Debian/Linux and Safari (version 5.0.3) on Mac OS X as clients, the motors can be controlled using a WebSocket-based Web-application. Diffractometer control application use in synchrotron radiation diffraction experiment was also developed. (author)

Preventive care utilization: Association with individual- and workgroup-level policy and practice perceptions.

Science.gov (United States)

Sabbath, Erika L; Sparer, Emily H; Boden, Leslie I; Wagner, Gregory R; Hashimoto, Dean M; Hopcia, Karen; Sorensen, Glorian

2018-06-01

Preventive medical care may reduce downstream medical costs and reduce population burden of disease. However, although social, demographic, and geographic determinants of preventive care have been studied, there is little information about how the workplace affects preventive care utilization. This study examines how four types of organizational policies and practices (OPPs) are associated with individual workers' preventive care utilization. We used data collected in 2012 from 838 hospital patient care workers, grouped in 84 patient care units at two hospitals in Boston. Via survey, we assessed individuals' perceptions of four types of OPPs on their work units. We linked the survey data to a database containing detailed information on medical expenditures. Using multilevel models, we tested whether individual-level perceptions, workgroup-average perceptions, and their combination were associated with individual workers' preventive care utilization (measured by number of preventive care encounters over a two-year period). Adjusting for worker characteristics, higher individual-level perceptions of workplace flexibility were associated with greater preventive care utilization. Higher average unit-level perceptions of people-oriented culture, ergonomic practices, and flexibility were associated with greater preventive care utilization. Overall, we find that workplace policies and practices supporting flexibility, ergonomics, and people-oriented culture are associated with positive preventive care-seeking behavior among workers, with some policies and practices operating at the individual level and some at the group level. Improving the work environment could impact employers' health-related expenditures and improve workers' health-related quality of life. Copyright © 2018 Elsevier Inc. All rights reserved.

Development of labelled biomolecules for targeted radiotherapy

International Nuclear Information System (INIS)

Arteaga de Murphy, C.

2000-01-01

The scope of the co-ordinated research project (Dec 15 1997) included the following activities: 1) develop coupling techniques using bifunctional chelating agents for monoclonal antibodies and peptides, 2) optimised radiolabelling procedures and reaction parameters using Sm-153 and Re-188, 3) investigate direct methods of labelling monoclonal antibodies and peptides with Re-188. 4) initiate animal distribution studies. The modifications specified for the period 1999/02/15 to 2000/02/14 are as follows: a) continue with the optimisation of Re-188-peptide labelling, b) continue with the work to prepare a kit, c) in-vivo and in-vitro studies, d) lanreotide labelling. The group formed by researchers from several Mexican Institutions have worked together and in different aspects of the CRP in order to fulfil the proposed aims (our published work listed)

Development of labelled biomolecules for targeted radiotherapy

Energy Technology Data Exchange (ETDEWEB)

Arteaga de Murphy, C [Instituto Nacional de la Nutricion Salvador Zubiran, Departmento de Medicina Nuclear, Mexico D.F. (Mexico). E-mail: cmurphy at data.net.mx

2000-07-01

The scope of the co-ordinated research project (Dec 15 1997) included the following activities: 1) develop coupling techniques using bifunctional chelating agents for monoclonal antibodies and peptides, 2) optimised radiolabelling procedures and reaction parameters using Sm-153 and Re-188, 3) investigate direct methods of labelling monoclonal antibodies and peptides with Re-188. 4) initiate animal distribution studies. The modifications specified for the period 1999/02/15 to 2000/02/14 are as follows: a) continue with the optimisation of Re-188-peptide labelling, b) continue with the work to prepare a kit, c) in-vivo and in-vitro studies, d) lanreotide labelling. The group formed by researchers from several Mexican Institutions have worked together and in different aspects of the CRP in order to fulfil the proposed aims (our published work listed)

Labelling of leucocytes with colloidal technetium-99m-SnF{sub 2}: an investigation of the labelling process by autoradiography

Energy Technology Data Exchange (ETDEWEB)

Puncher, M.R.B. [Biological Lab., Canterbury Univ. (United Kingdom); Blower, P.J. [Nuclear Medicine Dept., Kent and Canterbury Hospital, Canterbury (United Kingdom)

1995-02-01

Autoradiography of smears and frozen sections of labelled cell suspensions was used to study the distribution of radioactivity in and among blood cells labelled in either whole blood or leucocyte-rich plasma (LRP) with technetium-99m-SnF{sub 2} colloid. The tracer proved selective for neutrophils: the labelling probability (relative to that for erythrocytes) for each cell type in LRP (mean of five samples) was: neutrophils, 9.4; lymphocytes, 3.7; monocytes, 3.0; eosinophils 1.4; erythrocytes, 1.0. When labelling was carried out in whole blood (five samples), 74.5%{+-}8.3% of the cell-bound radioactivity was bound to erythrocytes, 13.6%{+-}6.5% to neutrophils, and 11.9%{+-}2.1% to lymphocytes, whereas in LRP (in which the leucocytes were only slightly outnumbered by erythrocytes), 76.5%{+-}14.9% of radioactivity was neutrophil bound. Labelled cells in smear autoradiographs exhibited two distinct silver grain patterns, ``diffuse``, consistent with an intracellular radioactive particle (in neutrophils), and ``focal``, consistent with a cell surface-adhering particle in direct contact with the emulsion (in other leucocyte types and erythrocytes). The phagocytic inhibitor cytochalasin B neither reduced the proportion of labelled neutrophils nor altered the labelling pattern. Neutrophils were able to scavenge radioactivity from the surface of erythrocytes. It is concluded that neutrophils bind {sup 99m}Tc-SnF{sub 2} intracellularly by phagocytosis, with high affinity; other cells become labelled at the cell surface reversibly and with lower affinity. This selectivity is high enough to permit predominantly leucocyte labelling in LRP but not in whole blood. (orig.)

Understanding the Web from an Economic Perspective: The Evolution of Business Models and the Web

Directory of Open Access Journals (Sweden)

Louis Rinfret

2014-08-01

Full Text Available The advent of the World Wide Web is arguably amongst the most important changes that have occurred since the 1990s in the business landscape. It has fueled the rise of new industries, supported the convergence and reshaping of existing ones and enabled the development of new business models. During this time the web has evolved tremendously from a relatively static pagedisplay tool to a massive network of user-generated content, collective intelligence, applications and hypermedia. As technical standards continue to evolve, business models catch-up to the new capabilities. New ways of creating value, distributing it and profiting from it emerge more rapidly than ever. In this paper we explore how the World Wide Web and business models evolve and we identify avenues for future research in light of the web‟s ever-evolving nature and its influence on business models.

Expert knowledge in palliative care on the World Wide Web: palliativedrugs.org.

Science.gov (United States)

Gavrin, Jonathan

2009-01-01

In my last Internet-related article, I speculated that social networking would be the coming wave in the effort to share knowledge among experts in various disciplines. At the time I did not know that a palliative care site on the World Wide Web (WWW), palliativedrugs.com, already provided the infrastructure for sharing expert knowledge in the field. The Web site is an excellent traditional formulary but it is primarily devoted to "unlicensed" ("off-label") use of medications in palliative care, something we in the specialty often do with little to support our interventions except shared knowledge and experience. There is nothing fancy about this Web site. In a good way, its format is a throwback to Web sites of the 1990s. In only the loosest sense can one describe it as "multimedia." Yet, it provides the perfect forum for expert knowledge and is a "must see" resource. Its existing content is voluminous and reliable, filtered and reviewed by renowned clinicians and educators in the field. Although its origin and structure were not specifically designed for social or professional networking, the Web site's format makes it a natural way for practitioners around the world to contribute to an ever-growing body of expertise in palliative care.

Co-Labeling for Multi-View Weakly Labeled Learning.

Science.gov (United States)

Xu, Xinxing; Li, Wen; Xu, Dong; Tsang, Ivor W

2016-06-01

It is often expensive and time consuming to collect labeled training samples in many real-world applications. To reduce human effort on annotating training samples, many machine learning techniques (e.g., semi-supervised learning (SSL), multi-instance learning (MIL), etc.) have been studied to exploit weakly labeled training samples. Meanwhile, when the training data is represented with multiple types of features, many multi-view learning methods have shown that classifiers trained on different views can help each other to better utilize the unlabeled training samples for the SSL task. In this paper, we study a new learning problem called multi-view weakly labeled learning, in which we aim to develop a unified approach to learn robust classifiers by effectively utilizing different types of weakly labeled multi-view data from a broad range of tasks including SSL, MIL and relative outlier detection (ROD). We propose an effective approach called co-labeling to solve the multi-view weakly labeled learning problem. Specifically, we model the learning problem on each view as a weakly labeled learning problem, which aims to learn an optimal classifier from a set of pseudo-label vectors generated by using the classifiers trained from other views. Unlike traditional co-training approaches using a single pseudo-label vector for training each classifier, our co-labeling approach explores different strategies to utilize the predictions from different views, biases and iterations for generating the pseudo-label vectors, making our approach more robust for real-world applications. Moreover, to further improve the weakly labeled learning on each view, we also exploit the inherent group structure in the pseudo-label vectors generated from different strategies, which leads to a new multi-layer multiple kernel learning problem. Promising results for text-based image retrieval on the NUS-WIDE dataset as well as news classification and text categorization on several real-world multi

Distribution of pagerank mass among principle components of the web

NARCIS (Netherlands)

Avrachenkov, Konstatin; Litvak, Nelli; Pham, Kim Son; Bonato, A.; Chung, F.R.K.

2007-01-01

We study the PageRank mass of principal components in a bow-tie Web Graph, as a function of the damping factor c. Using a singular perturbation approach, we show that the PageRank share of IN and SCC components remains high even for very large values of the damping factor, in spite of the fact that

Labelling of biological structures with technetium 99 m

International Nuclear Information System (INIS)

Bernardo Filho, M.

1988-01-01

The labelling of red blood cells (RBC) with technetium 99m ( 99m Tc) depends on several factors, as the stannous ion (Sn ++ ) concentration, the time and temperature of incubation, the anticoagulant utilized, the presence of plasma proteins (PP) and others. Although the blinding of 99m Tc with hemoglobin and PP are similar, they appear to have specific characteristics as demonstrated by precipitation with alcohol, acetone, trichloroacetic acid, hydrochloric acid and mercury chloride. The bacterial cultures labeled with Technetium- 99m , at optimal Sn ++ ion concentration, presents a large stability and their viability is not altered by this treatment. The electrophoretic mobility, the hydrophobicity, the cationized ferritin distribution and the adherence to human buccal epithelial cells are not modified either. The possibility of labelling with 99m Tc of planaria and cercariae of Schistossoma mansoni evaluative cycle increases the utilization of this radionuclide to an experimental level. The results described with the labelling of these biological structures with 99m Tc demonstrated that stable labeled and viable operations are obtained. (author)

Tritiated bovine fibrinogen labelled in fibrinopeptide A region

International Nuclear Information System (INIS)

Wegrzynowicz, Z.; Kloczewiak, M.; Kopec, M.

1974-01-01

The method is described for labelling of bovine fibrinogen with 3 H-AcOAc. Preparations labelled at pH 7.8 with 10 to 40 molar excess of 3 H-AcOAc were found to contain 8 to 13 moles of acetyl residues per mole of fibrinogen. The content of clottable protein and UV spectra were unchanged as compared with control unlabelled preprations. The rate of clotting with thrombin was only slightly affected. The investigations on distribution of 3 H in products of proteolysis of 3 H-fibrinogen by thrombin and plasmin demonstrated a preferential labelling of fibrinopeptide A, absence of radioactive tracer in fibrinopeptide B, significantly higher specific radioactivity of fragment E than that of fragment D. Incorporation of the label into fibrinopeptide A opens the possibility for application of 3 H-fibrinogen as a convenient substrate for selective investigations on the enzymatic phase of clotting. (author)

Application of product life cycle concept to private label management

Directory of Open Access Journals (Sweden)

Sandra Horvat

2013-06-01

Full Text Available Private labels have recorded significant growth rates worldwide, becoming a serious threat to manufacturer brands. Development of private labels in many different product categories increased the complexity of their management. Therefore, this paper examines the possibility of using the product life cycle concept in private label management. Given that private labels are a specific brand type, it is necessary to adjust certain elements of the product life cycle concept, as it was developed on the basis of manufacturer brands. For instance, in the growth stage of the product life cycle, retailers expand private labels to a number of product categories and use the push strategy while manufacturers tend to expand their distribution network in the expansion of their brands and predominantly use the pull strategy in doing so. Furthermore, there is a focus shift from low-price strategy, predominantly used in the introduction phase, to increasing the quality and private label value in the later stages of the product life cycle.

Web server for priority ordered multimedia services

Science.gov (United States)

Celenk, Mehmet; Godavari, Rakesh K.; Vetnes, Vermund

2001-10-01

In this work, our aim is to provide finer priority levels in the design of a general-purpose Web multimedia server with provisions of the CM services. The type of services provided include reading/writing a web page, downloading/uploading an audio/video stream, navigating the Web through browsing, and interactive video teleconferencing. The selected priority encoding levels for such operations follow the order of admin read/write, hot page CM and Web multicasting, CM read, Web read, CM write and Web write. Hot pages are the most requested CM streams (e.g., the newest movies, video clips, and HDTV channels) and Web pages (e.g., portal pages of the commercial Internet search engines). Maintaining a list of these hot Web pages and CM streams in a content addressable buffer enables a server to multicast hot streams with lower latency and higher system throughput. Cold Web pages and CM streams are treated as regular Web and CM requests. Interactive CM operations such as pause (P), resume (R), fast-forward (FF), and rewind (RW) have to be executed without allocation of extra resources. The proposed multimedia server model is a part of the distributed network with load balancing schedulers. The SM is connected to an integrated disk scheduler (IDS), which supervises an allocated disk manager. The IDS follows the same priority handling as the SM, and implements a SCAN disk-scheduling method for an improved disk access and a higher throughput. Different disks are used for the Web and CM services in order to meet the QoS requirements of CM services. The IDS ouput is forwarded to an Integrated Transmission Scheduler (ITS). The ITS creates a priority ordered buffering of the retrieved Web pages and CM data streams that are fed into an auto regressive moving average (ARMA) based traffic shaping circuitry before being transmitted through the network.

Rapid localization of carbon 14-labeled molecules in biological samples by ion mass microscopy

International Nuclear Information System (INIS)

Hindie, E.; Escaig, F.; Coulomb, B.; Lebreton, C.; Galle, P.

1989-01-01

We report here on the ability of secondary ion mass spectrometry (SIMS) to provide rapid imaging of the intracellular distribution of 14 C-labeled molecules. The validity of this method, using mass discrimination of carbon 14 atoms, was assessed by imaging the distribution of two molecules of well-known metabolism, [ 14 C]-thymidine and [ 14 C]-uridine, incorporated by human fibroblasts in culture. As expected, 14 C ion images showed the presence of [ 14 C]-thymidine in the nucleus of dividing cells, whereas [ 14 C]-uridine was present in the cytoplasm as well as the nucleus of all cells, with a large concentration in the nucleoli. The time required to obtain the distribution images with the SMI 300 microscope was less than 6 min, whereas microautoradiography, the classical method for mapping the tissue distribution of 14 C-labeled molecules, usually requires exposure times of several months. Secondary ion mass spectrometry using in situ mass discrimination is proposed here as a very sensitive method which permits rapid imaging of the subcellular distribution of molecules labeled with carbon 14

Beginning ASPNET Web Pages with WebMatrix

CERN Document Server

Brind, Mike

2011-01-01

Learn to build dynamic web sites with Microsoft WebMatrix Microsoft WebMatrix is designed to make developing dynamic ASP.NET web sites much easier. This complete Wrox guide shows you what it is, how it works, and how to get the best from it right away. It covers all the basic foundations and also introduces HTML, CSS, and Ajax using jQuery, giving beginning programmers a firm foundation for building dynamic web sites.Examines how WebMatrix is expected to become the new recommended entry-level tool for developing web sites using ASP.NETArms beginning programmers, students, and educators with al

Thrombokinetics with In-111-oxine labelled platelets

International Nuclear Information System (INIS)

Uchida, Tatsumi; Yui, Tokuo; Muroi, Shuichi; Matsuda, Shin; Kariyone, Shigeo

1982-01-01

Indium-111-oxine has been employed as a redioactive platelet label for thrombosis imaging and thrombokinetic studies in man. To evaluate it's suitability for platelet survival and turnover, thrombokinetic studies were carried out in hematological normal subjects, in patients with idiopathic thrombocytopenic purpura (ITP) and chronic congestive splenomegaly. For In-111-oxine labelled platelets, platelets were collected by differential centrifugation from 44 ml of whole blood drawn into 6 ml of acid citrate dextrose solution. Platelet suspension was incubated with In-111-oxine, which was extracted before use by the method of Thakur and co-workers. The survival, recovery and turnover of In-111-labeled platelets were 8.6 +- 0.5 days, 63.0 +- 5.4% and 3.9 +- 0.3 x 10 4 / μl/day, respectively, which were similar with those of Cr-51 method. Platelet disappearance curves labelled with In-111 and Cr-51 simultaneously were similar in one case. In patients with ITP, platelet survival shortened in the same degree with Cr-51 method. The two simultaneous labeling studies between In-111 and Cr-51 showed no differences. In the patients with congestive splenomegaly, the same results were obtained. Thrombokinetic studies with In-111-oxine labelled platelets offer the advantages of reduced blood requirements, and the ability to perform external imaging of platelet distribution. (author)

E-Learning System Overview Based on Semantic Web

Science.gov (United States)

Alsultanny, Yas A.

2006-01-01

The challenge of the semantic web is the provision of distributed information with well-defined meaning, understandable for different parties. e-Learning is efficient task relevant and just-in-time learning grown from the learning requirements of the new dynamically changing, distributed business world. In this paper we design an e-Learning system…

Labeling of - N-Isopropil - p - I-Anphetamine (IMP-131I) and its biological distribution in rats

International Nuclear Information System (INIS)

Barboza, M.F. de; Goncalves, R.S.V.; Muramoto, E.

1988-09-01

The described labeling and purification preparation of N-Isopropil-p 131 I-anphetamine ( 131 I-IMP) represents a fast and efficient method to obtains a compound that fullfills all criterions of purity for its application 'IN VIVO'. The labeling yield was 68-78% and the radiochemical purity performed by paper chromatography and electrophorese was 97-99%. As demostrated in animal experiments, the cerebral affinity offers a possibility to study brain diseases in clinical studies when the product will be labelled with 123 I. (author) [pt

Non-visual Web Browsing: Beyond Web Accessibility.

Science.gov (United States)

Ramakrishnan, I V; Ashok, Vikas; Billah, Syed Masum

2017-07-01

People with vision impairments typically use screen readers to browse the Web. To facilitate non-visual browsing, web sites must be made accessible to screen readers, i.e., all the visible elements in the web site must be readable by the screen reader. But even if web sites are accessible, screen-reader users may not find them easy to use and/or easy to navigate. For example, they may not be able to locate the desired information without having to listen to a lot of irrelevant contents. These issues go beyond web accessibility and directly impact web usability. Several techniques have been reported in the accessibility literature for making the Web usable for screen reading. This paper is a review of these techniques. Interestingly, the review reveals that understanding the semantics of the web content is the overarching theme that drives these techniques for improving web usability.

In vivo distribution of Tc-99m labeled recombinant tissue-type plasminogen activator in control and thrombus-bearing rats

International Nuclear Information System (INIS)

Tsukamoto, Eriko

1992-01-01

In vivo distribution of Tc-99m labeled recombinant tissue-type plasminogen activator (Tc-99m-rt-PA) was studied in control rats and thrombus-bearing rats. To compare fibrin binding in vivo with that in vitro, Tc-99m-rt-PA binding to fibrin gel in vitro was also imaged. Rapid blood clearance and accumulation into the liver and kidneys were observed in both control and thrombus-bearing rats. Accumulation in the stomach, which indicates instability of labeled rt-PA in vivo, was very low until two hours after injection. Tc-99m-rt-PA accumulation in the clots was higher than that in skeletal and heart muscles, although it was lower than in blood, liver, and kidneys. Administration of aprotinin, an antifibrinolytic agent, significantly prolonged clot accumulation of Tc-99m-rt-PA at 30 minutes after injection. These results suggest that fibrinolysis is responsible for the low rt-PA concentration in the clots. A scintigram of a thrombus-bearing rat demonstrated increased radioactivity at the clot forming site. On the other hand, Tc-99m-labeled human albumin, which was used as a control, was not accumulated in the clot. Tc-99m-rt-PA binding to fibrin gel in vitro was clearly imaged. By comparison, in vivo fibrin binding of Tc-99m-rt-PA was much lower than in vitro. The reasons for low thrombus uptake in vivo may be: (1) biochemical inactivation of extrinsically administered rt-PA by t-PA inhibitor; (2) fibrinolysis by rt-PA activated plasminogen. Overcoming these limitations will enable Tc-99m-rt-PA to reach the stage of clinical trials. (author)

Maintaining Web Cache Coherency

Directory of Open Access Journals (Sweden)

2000-01-01

Full Text Available Document coherency is a challenging problem for Web caching. Once the documents are cached throughout the Internet, it is often difficult to keep them coherent with the origin document without generating a new traffic that could increase the traffic on the international backbone and overload the popular servers. Several solutions have been proposed to solve this problem, among them two categories have been widely discussed: the strong document coherency and the weak document coherency. The cost and the efficiency of the two categories are still a controversial issue, while in some studies the strong coherency is far too expensive to be used in the Web context, in other studies it could be maintained at a low cost. The accuracy of these analysis is depending very much on how the document updating process is approximated. In this study, we compare some of the coherence methods proposed for Web caching. Among other points, we study the side effects of these methods on the Internet traffic. The ultimate goal is to study the cache behavior under several conditions, which will cover some of the factors that play an important role in the Web cache performance evaluation and quantify their impact on the simulation accuracy. The results presented in this study show indeed some differences in the outcome of the simulation of a Web cache depending on the workload being used, and the probability distribution used to approximate updates on the cached documents. Each experiment shows two case studies that outline the impact of the considered parameter on the performance of the cache.

Web-based Analysis Services Report

CERN Document Server

AUTHOR|(CDS)2108758; Canali, Luca; Grancher, Eric; Lamanna, Massimo; McCance, Gavin; Mato Vila, Pere; Piparo, Danilo; Moscicki, Jakub; Pace, Alberto; Brito Da Rocha, Ricardo; Simko, Tibor; Smith, Tim; Tejedor Saavedra, Enric; CERN. Geneva. IT Department

2017-01-01

Web-based services (cloud services) is an important trend to innovate end-user services while optimising the service operational costs. CERN users are constantly proposing new approaches (inspired from services existing on the web, tools used in education or other science or based on their experience in using existing computing services). In addition, industry and open source communities have recently made available a large number of powerful and attractive tools and platforms that enable large scale data processing. “Big Data” software stacks notably provide solutions for scalable storage, distributed compute and data analysis engines, data streaming, web-based interfaces (notebooks). Some of those platforms and tools, typically available as open source products, are experiencing a very fast adoption in industry and science such that they are becoming “de facto” references in several areas of data engineering, data science and machine learning. In parallel to users' requests, WLCG is considering to c...

[Consumer reaction to information on the labels of genetically modified food].

Science.gov (United States)

Sebastian-Ponce, Miren Itxaso; Sanz-Valero, Javier; Wanden-Berghe, Carmina

2014-02-01

To analyze consumer opinion on genetically modified foods and the information included on the label. A systematic review of the scientific literature on genetically modified food labeling was conducted consulting bibliographic databases (Medline - via PubMed -, EMBASE, ISI-Web of knowledge, Cochrane Library Plus, FSTA, LILACS, CINAHL and AGRICOLA) using the descriptors "organisms, genetically modified" and "food labeling". The search covered the first available date, up to June 2012, selecting relevant articles written in English, Portuguese or Spanish. Forty articles were selected after applying the inclusion and exclusion criteria. All of them should have conducted a population-based intervention focused on consumer awareness of genetically modified foods and their need or not, to include this on the label. The consumers expressed a preference for non-genetically modified products, and added that they were prepared to pay more for this but, ultimately, the product bought was that with the best price, in a market which welcomes new technologies. In 18 of the articles, the population was in favor of obligatory labelling, and in six, in favor of this being voluntary; seven studies showed the consumer knew little about genetically modified food, and in three, the population underestimated the quantity they consumed. Price was an influencing factor in all cases. Label should be homogeneous and clarify the degree of tolerance of genetically modified products in humans, in comparison with those non-genetically modified. Label should also present the content or not of genetically modified products and how these commodities are produced and should be accompanied by the certifying entity and contact information. Consumers express their preference for non-genetically modified products and they even notice that they are willing to pay more for it, but eventually they buy the item with the best price, in a market that welcomes new technologies.

Distribution of polycyclic aromatic hydrocarbons in the food web of a high mountain lake, Pyrenees, Catalonia, Spain.

Science.gov (United States)

Vives, Ingrid; Grimalt, Joan O; Ventura, Marc; Catalan, Jordi

2005-06-01

We investigated the contents of polycyclic aromatic hydrocarbons (PAHs) in the food web organisms included in the diet of brown trout from a remote mountain lake. The preferential habitat and trophic level of the component species have been assessed from the signature of stable isotopes (delta13C and delta15N). Subsequently, the patterns of accumulation and transformation of these hydrocarbons in the food chain have been elucidated. Most of the food web organisms exhibit PAH distributions largely dominated by phenanthrene, which agrees with its predominance in atmospheric deposition, water, and suspended particles. Total PAH levels are higher in the organisms from the littoral habitat than from the deep sediments or the pelagic water column. However, organisms from deep sediments exhibit higher proportions of higher molecular weight PAH than those in other lake areas. Distinct organisms exhibit specific features in their relative PAH composition that point to different capacities for uptake and metabolic degradation. Brown trout show an elevated capacity for metabolic degradation because they have lower PAH concentrations than food and they are enriched strongly in lower molecular weight compounds. The PAH levels in trout highly depend on organisms living in the littoral areas. Fish exposure to PAH, therefore, may vary from lake to lake according to the relative contribution of littoral organisms to their diet.

VideoWeb Dataset for Multi-camera Activities and Non-verbal Communication

Science.gov (United States)

Denina, Giovanni; Bhanu, Bir; Nguyen, Hoang Thanh; Ding, Chong; Kamal, Ahmed; Ravishankar, Chinya; Roy-Chowdhury, Amit; Ivers, Allen; Varda, Brenda

Human-activity recognition is one of the most challenging problems in computer vision. Researchers from around the world have tried to solve this problem and have come a long way in recognizing simple motions and atomic activities. As the computer vision community heads toward fully recognizing human activities, a challenging and labeled dataset is needed. To respond to that need, we collected a dataset of realistic scenarios in a multi-camera network environment (VideoWeb) involving multiple persons performing dozens of different repetitive and non-repetitive activities. This chapter describes the details of the dataset. We believe that this VideoWeb Activities dataset is unique and it is one of the most challenging datasets available today. The dataset is publicly available online at http://vwdata.ee.ucr.edu/ along with the data annotation.

76 FR 39477 - Revisions and Additions to Motor Vehicle Fuel Economy Label

Science.gov (United States)

2011-07-06

...The Environmental Protection Agency (EPA) and the National Highway Traffic Safety Administration (NHTSA) are issuing a joint final rule establishing new requirements for the fuel economy and environment label that will be posted on the window sticker of all new automobiles sold in the U.S. The labeling requirements apply for model year 2013 and later vehicles with a voluntary manufacturer option for model year 2012. The labeling requirements apply to passenger cars, light-duty trucks, and medium duty passenger vehicles such as larger sport-utility vehicles and vans. The redesigned label provides expanded information to American consumers about new vehicle fuel economy and fuel consumption, greenhouse gas and smog-forming emissions, and projected fuel costs and savings, and also includes a smartphone interactive code that permits direct access to additional Web resources. Specific label designs are provided for gasoline, diesel, ethanol flexible fuel, compressed natural gas, electric, plug-in hybrid electric, and hydrogen fuel cell vehicles. This rulemaking is in response to provisions in the Energy Independence and Security Act of 2007 that imposed several new labeling requirements and new advanced-technology vehicles entering the market. NHTSA and EPA believe that these changes will help consumers to make more informed vehicle purchase decisions, particularly as the future automotive marketplace provides more diverse vehicle technologies from which consumers may choose. These new label requirements do not affect the methodologies that EPA uses to generate consumer fuel economy estimates, or the automaker compliance values for NHTSA's corporate average fuel economy and EPA's greenhouse gas emissions standards. This action also finalizes a number of technical corrections to EPA's light-duty greenhouse gas emission standards program.

A comparative study of preliminary dosimetry for human based on distribution data in rats with 111In, 90Y, 153Sm, and 177Lu labeled rituximab

Directory of Open Access Journals (Sweden)

Radfar Edalat

2012-01-01

Full Text Available Radio immunotherapy is one of the most important and effective therapies for B-cell non Hoddgkin’s lymphoma treatment. Today, anti CD-20 antibodies labeled with beta emitter radionuclides are used in radio immunotherapy. Various radionuclides for labeling anti CD-20 antibodies have been studied and developed for the treatment and diagnosis of malignancies. This paper describes the preparation, bio-distribution and absorbed dose rate of 111In, 90Y, 177Lu, and 153Sm labeled anti CD-20 antibodies (rituximab in human organs, after injection to rats. The macro cyclic bifunctional chelating agent, N-succinimidyl-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid (DOTA-NHS for conjugation to antibody, was used to prepare DOTA-rituximab. The conjugates were purified by molecular filtration, the average number of DOTA conjugated per mAb was calculated and total concentration was determined by spectrophotometric method. Radio-labeling was performed at 40 °C for 24 hours. After the quality control studies, the final radioactive solution was injected intravenously into rats through their tail vein. The tissue uptakes of each injection were measured. Then we calculated S values for 177Lu and 153Sm by using specific absorbed fractions and data used in the manner of radio-labeled analysis and dosimetry for humans. The absorbed dose rate of each organ was calculated in the specific time by medical internal radiation dose method with linear approximation in the activity measurements.

99mTc labeling of the scorpion (Tityus serrulatus) antivenom

International Nuclear Information System (INIS)

Cardoso, D.S.; Nunan, E.A.; Toledo, V.P.C.P.; Moraes-Santos, T.; Cardoso, V.N.

2008-01-01

F(ab') 2 is the fragment involved in the immunotherapy for scorpion stings and it would be convenient to label it with 99m Tc for organ distribution and pharmacokinetics studies. The aim of the present study was to label scorpion antivenom F(ab') 2 with 99m Tc keeping its biological activity, integrity and stability. High labeling yield was obtained using stannous chloride and sodium borohydride. Stability, immunoreactivity and integrity of 99m Tc-F(ab') 2 was preserved. It was not observed any difference between potencies of unlabeled and labeled antivenom. 99m Tc-F(ab') 2 can be a useful tool for use in biodistribution and pharmacokinetics studies on the evaluation of the efficacy of the antivenom against scorpion envenomation. (author)

Label Review Training: Module 1: Label Basics, Page 21

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. Learn about types of labels.

Label Review Training: Module 1: Label Basics, Page 22

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. Learn about what labels require review.

Label Review Training: Module 1: Label Basics, Page 19

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. This section covers supplemental distributor labeling.

Distribution of distances between DNA barcode labels in nanochannels close to the persistence length

Science.gov (United States)

Reinhart, Wesley F.; Reifenberger, Jeff G.; Gupta, Damini; Muralidhar, Abhiram; Sheats, Julian; Cao, Han; Dorfman, Kevin D.

2015-02-01

We obtained experimental extension data for barcoded E. coli genomic DNA molecules confined in nanochannels from 40 nm to 51 nm in width. The resulting data set consists of 1 627 779 measurements of the distance between fluorescent probes on 25 407 individual molecules. The probability density for the extension between labels is negatively skewed, and the magnitude of the skewness is relatively insensitive to the distance between labels. The two Odijk theories for DNA confinement bracket the mean extension and its variance, consistent with the scaling arguments underlying the theories. We also find that a harmonic approximation to the free energy, obtained directly from the probability density for the distance between barcode labels, leads to substantial quantitative error in the variance of the extension data. These results suggest that a theory for DNA confinement in such channels must account for the anharmonic nature of the free energy as a function of chain extension.

Label Review Training: Module 1: Label Basics, Page 15

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. Learn about the consequences of improper labeling.

Label Review Training: Module 1: Label Basics, Page 14

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. Learn about positive effects from proper labeling.

Label Review Training: Module 1: Label Basics, Page 18

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. This section discusses the types of labels.

Label Review Training: Module 1: Label Basics, Page 26

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. Learn about mandatory and advisory label statements.

Intrinsic labeling of alpha-fetoprotein with 65Zn

International Nuclear Information System (INIS)

Preiss, I.L.

1994-01-01

Many enzymes, proteins, and large molecules bind a variety of inorganic ions. The replacement of a specific metal ion with another element can disrupt the biodistribution and biochemistry of the host molecule. Alpha-fetoprotein (AFP) is a known oncofetal antigen. The authors have demonstrated that the substitution of Cu or Pb on AFP inhibits the transplacental migration of AFP and may lead to fetal demise. It is evident that in labeling with a radiotracer in order to observe the true distribution of a molecule, one must select a radioisotope of an element which is naturally bound to the host molecule. It has been demonstrated that AFP binds Zn in vivo. Thus, substituting 65 Zn for natural Zn produces an intrinsic label for AFP. The authors discuss the methodology for stripping and labeling of AFP with 65 Zn. The biodistribution of labeled AFP is compared with that of 65 Zn 2+ in healthy and diseased (hepatoma) animals

Eelgrass (Zostera marina) food web structure in different environmental settings

DEFF Research Database (Denmark)

Thormar, Jonas Gjaldbæk; Hasler-Sheetal, Harald; Baden, Susanne

2016-01-01

his study compares the structure of eelgrass (Zostera marina L.) meadows and associated food webs in two eelgrass habitats in Denmark, differing in exposure, connection to the open sea, nutrient enrichment and water transparency. Meadow structure strongly reflected the environmental conditions...... composition and food web structure also differed markedly between sites with the eutrophicated, enclosed site having higher biomass of consumers and less complex food web. These relationships resulted in a column shaped biomass distribution of the consumers at the eutrophicated site whereas the less nutrient...

Label Review Training: Module 1: Label Basics, Page 24

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. This page is about which labels require review.

Label Review Training: Module 1: Label Basics, Page 27

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. See examples of mandatory and advisory label statements.

Label Review Training: Module 1: Label Basics, Page 17

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. See an overview of the importance of labels.

Web Caching

Indian Academy of Sciences (India)

leveraged through Web caching technology. Specifically, Web caching becomes an ... Web routing can improve the overall performance of the Internet. Web caching is similar to memory system caching - a Web cache stores Web resources in ...

Label Review Training: Module 1: Label Basics, Page 23

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. Lists types of labels that do not require review.

Development of web database system for JAERI ERL-FEL

International Nuclear Information System (INIS)

Kikuzawa, Nobuhiro

2005-01-01

The accelerator control system for the JAERI ERL-FEL is a PC-based distributed control system. The accelerator status record is stored automatically through the control system to analyze the influence on the electron beam. In order to handle effectively a large number of stored data, it is necessary that the required data can be searched and visualized in easy operation. For this reason, a web database (DB) system which can search of the required data and display visually on a web browser was developed by using open source software. With introduction of this system, accelerator operators can monitor real-time information anytime, anywhere through a web browser. Development of the web DB system is described in this paper. (author)

Development of web database system for JAERI ERL-FEL

Energy Technology Data Exchange (ETDEWEB)

Kikuzawa, Nobuhiro [Japan Atomic Energy Research Inst., Kansai Research Establishment, Advanced Photon Research Center, Tokai, Ibaraki (Japan)

2005-06-01

The accelerator control system for the JAERI ERL-FEL is a PC-based distributed control system. The accelerator status record is stored automatically through the control system to analyze the influence on the electron beam. In order to handle effectively a large number of stored data, it is necessary that the required data can be searched and visualized in easy operation. For this reason, a web database (DB) system which can search of the required data and display visually on a web browser was developed by using open source software. With introduction of this system, accelerator operators can monitor real-time information anytime, anywhere through a web browser. Development of the web DB system is described in this paper. (author)

Uptake of labelled tallysomycin by solid Ehrlich ascites tumors in mice

International Nuclear Information System (INIS)

Liniecki, J.; Rembelska, M.; Koniarek, B.

1983-01-01

Tumor and normal tissue uptake of 51 Cr- or 57 Co-labelled bleomycin (BLEO) and tallysomycin (TLM) was compared in female solid Ehrlich ascites tumor mice of Swiss strain. The complexes were administered intraperitoneally: 30-50 μg of each complex with an activity of 40-120 μCi. Activity distribution factors (ADF) and tumor/non-tumor ratios for blood, bone, skeletal muscles, kidneys and liver were determined. The ratios were generally higher for complexes labelled with 57 Co than for the 51 Cr-labelled ones; bleomycin appears equivalent or superior to tallysomycin. (orig.) [de

AIRSAR Automated Web-based Data Processing and Distribution System

Science.gov (United States)

Chu, Anhua; vanZyl, Jakob; Kim, Yunjin; Lou, Yunling; Imel, David; Tung, Wayne; Chapman, Bruce; Durden, Stephen

2005-01-01

In this paper, we present an integrated, end-to-end synthetic aperture radar (SAR) processing system that accepts data processing requests, submits processing jobs, performs quality analysis, delivers and archives processed data. This fully automated SAR processing system utilizes database and internet/intranet web technologies to allow external users to browse and submit data processing requests and receive processed data. It is a cost-effective way to manage a robust SAR processing and archival system. The integration of these functions has reduced operator errors and increased processor throughput dramatically.

Distributing flight dynamics products via the World Wide Web

Science.gov (United States)

Woodard, Mark; Matusow, David

1996-01-01

The NASA Flight Dynamics Products Center (FDPC), which make available selected operations products via the World Wide Web, is reported on. The FDPC can be accessed from any host machine connected to the Internet. It is a multi-mission service which provides Internet users with unrestricted access to the following standard products: antenna contact predictions; ground tracks; orbit ephemerides; mean and osculating orbital elements; earth sensor sun and moon interference predictions; space flight tracking data network summaries; and Shuttle transport system predictions. Several scientific data bases are available through the service.

Multiscale phenomenology of the cosmic web

NARCIS (Netherlands)

Aragón-Calvo, Miguel A.; van de Weygaert, Rien; Jones, Bernard J. T.

2010-01-01

We analyse the structure and connectivity of the distinct morphologies that define the cosmic web. With the help of our multiscale morphology filter (MMF), we dissect the matter distribution of a cosmological Lambda cold dark matter N-body computer simulation into cluster, filaments and walls. The

Label Review Training: Module 1: Label Basics, Page 16

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. Learn about the importance of labels and the role in enforcement.

Efficient Multi-Label Feature Selection Using Entropy-Based Label Selection

Directory of Open Access Journals (Sweden)

Jaesung Lee

2016-11-01

Full Text Available Multi-label feature selection is designed to select a subset of features according to their importance to multiple labels. This task can be achieved by ranking the dependencies of features and selecting the features with the highest rankings. In a multi-label feature selection problem, the algorithm may be faced with a dataset containing a large number of labels. Because the computational cost of multi-label feature selection increases according to the number of labels, the algorithm may suffer from a degradation in performance when processing very large datasets. In this study, we propose an efficient multi-label feature selection method based on an information-theoretic label selection strategy. By identifying a subset of labels that significantly influence the importance of features, the proposed method efficiently outputs a feature subset. Experimental results demonstrate that the proposed method can identify a feature subset much faster than conventional multi-label feature selection methods for large multi-label datasets.

Association of perception of front-of-pack labels with dietary, lifestyle and health characteristics.

Science.gov (United States)

Méjean, Caroline; Macouillard, Pauline; Péneau, Sandrine; Lassale, Camille; Hercberg, Serge; Castetbon, Katia

2014-01-01

To identify patterns of perception of front-of-pack (FOP) nutrition labels and determine dietary, lifestyle and health profiles related to such patterns. Cross-sectional. 28,952 French adults participating in the web-based Nutrinet-Santé cohort. Perception was measured using indicators of understanding and acceptability for three simple FOP labels ("green tick", the logo of the French Nutrition and Health Program and "simple traffic lights" (STL)), and two detailed FOP formats ("multiple traffic lights" (MTL) and "color range" logo (CR)), placed on ready-to-eat soup packages. Dietary intake data were collected using three web-based 24 h records. Associations of perception patterns with individual characteristics, including diet, lifestyle and health status, were examined using analysis of covariance and logistic regression, adjusted for socio-demographic and economic factors. No clear trend emerged concerning differences in dietary intake between perception groups. Low physical activity and obesity were more frequent in the 'favorable to STL' group (respectively, 20.7% and 10.7%). The 'favorable to MTL' group included the highest percentage of individuals who declared type 2 diabetes (2.2%). Persons with hypertension were proportionally more numerous in the 'favorable to MTL' and the 'favorable to CR logo' groups (respectively, 9.5% and 9.3%). After adjustment for socio-demographic and economic factors, no FOP label stood out as being more suitable than another for reaching populations with poor diet. However, both STL and MTL may be most appropriate for increasing awareness of healthy eating among groups at higher risk of nutrition-related chronic diseases.

Labeled factor IX kinetics in patients with hemophilia-B

International Nuclear Information System (INIS)

Smith, K.J.; Thompson, A.R.

1981-01-01

Labeled factor IX was infused five time into four patients with hemophilia-B. Ten-minute plasma recovery average 35% (SD +/- 2) and the mean T 1/2 beta-phase elimination was 23 hr (+/- 5). No alteration in the postinfusion 125I-factor-IX could be detected by radioautography of plasma samples run on polyacrylamide gels or on crossed-immunoelectrophoresis. Label was excreted into the urine as free 125I-iodide. Kinetics were similar when the labeled preparation was infused alone or with a commercial concentrate containing unlabeled factor IX. Infusion of factor IX in man is best described by a two-compartment open pharmacokinetic model where factor IX is distributed in a space larger than the plasma volume

Modern spectrometric methods for the analysis of labelled compounds

International Nuclear Information System (INIS)

Kaspersen, F.M.; Funke, C.W.; Wagenaars, G.N.; Jacobs, P.L.

1988-01-01

A proper analysis of chemical compounds should give information about the chemical identity (not only the structure but also enantiomeric form), the chemical purity and chemical composition (e.g. giving information about counter-ions, solvents of crystallization). For labelled compounds information is also needed about isotopic purity (defined as the % of isotope present in the compound), the position/distribution of the isotope in the molecule and degree of labelling/specific activity. In the past ten years the possibilities for spectrometric analyses of labelled compounds have increased enormously and this chapter will give an overview of these methods with the exception of (radio)chromatography that will be dealt with in another chapter. (author)

Model-Checking Web Services Business Activity Protocols

DEFF Research Database (Denmark)

Marques, Abinoam P.; Ravn, Anders Peter; Srba, Jiri

2013-01-01

Web Services Business Activity specification defines two coordination protocols BAwCC (Business Agreement with Coordination Completion) and BAwPC (Business Agreement with Participant Completion)that ensure a consistent agreement on the outcome of long-running distributed applications. In order...

A Survey on Trust-Based Web Service Provision Approaches

DEFF Research Database (Denmark)

Dragoni, Nicola

2010-01-01

The basic tenet of Service-Oriented Computing (SOC) is the possibility of building distributed applications on the Web by using Web Services as fundamental building blocks. The proliferation of such services is considered the second wave of evolution in the Internet age, moving the Web from...... a collection of pages to a collections of services. Consensus is growing that this Web Service “revolution” won't eventuate until we resolve trust-related issues. Indeed, the intrinsic openness of the SOC vision makes crucial to locate useful services and recognize them as trustworthy. In this paper we review...... the field of trust-based Web Service selection, providing a structured classification of current approaches and highlighting the main limitations of each class and of the overall field. As a result, we claim that a soft notion of trust lies behind such weaknesses and we advocate the need of a new approach...

Multi-label Learning with Missing Labels Using Mixed Dependency Graphs

KAUST Repository

Wu, Baoyuan; Jia, Fan; Liu, Wei; Ghanem, Bernard; Lyu, Siwei

2018-01-01

This work focuses on the problem of multi-label learning with missing labels (MLML), which aims to label each test instance with multiple class labels given training instances that have an incomplete/partial set of these labels (i.e., some

WebSelF: A Web Scraping Framework

DEFF Research Database (Denmark)

Thomsen, Jakob; Ernst, Erik; Brabrand, Claus

2012-01-01

We present, WebSelF, a framework for web scraping which models the process of web scraping and decomposes it into four conceptually independent, reusable, and composable constituents. We have validated our framework through a full parameterized implementation that is flexible enough to capture...... previous work on web scraping. We have experimentally evaluated our framework and implementation in an experiment that evaluated several qualitatively different web scraping constituents (including previous work and combinations hereof) on about 11,000 HTML pages on daily versions of 17 web sites over...... a period of more than one year. Our framework solves three concrete problems with current web scraping and our experimental results indicate that com- position of previous and our new techniques achieve a higher degree of accuracy, precision and specificity than existing techniques alone....

Stem cell monitoring with a direct or indirect labeling method

Energy Technology Data Exchange (ETDEWEB)