Stiffness of lipid monolayers with phase coexistence.
Caruso, Benjamín; Mangiarotti, Agustín; Wilke, Natalia
2013-08-27
The surface dilational modulus--or compressibility modulus--has been previously studied for monolayers composed of pure materials, where a jump in this modulus was related with the onset of percolation as a result of the establishment of a connected structure at the molecular level. In this work, we focused on monolayers composed of two components of low lateral miscibility. Our aim was to investigate the compressibility of mixed monolayers at pressures and compositions in the two-phase region of the phase diagram, in order to analyze the effect of the mechanical properties of each phase on the stiffness of the composite. In nine different systems with distinct molecular dipoles and charges, the stiffness of each phase and the texture at the plane of the monolayer were studied. In this way, we were able to analyze the general compressibility of two-phase lipid monolayers, regardless of the properties of their constituent parts. The results are discussed in the light of the following two hypotheses: first, the stiffness of the composite could be dominated by the stiffness of each phase as a weighted sum according to the percentage of each phase area, regardless of the distribution of the phases in the plane of the monolayer. Alternatively, the stiffness of the composite could be dominated by the mechanical properties of the continuous phase. Our results were better explained by this latter proposal, as in all the analyzed mixtures it was found that the mechanical properties of the percolating phase were the determining factors. The value of the compression modulus was closer to the value of the connected phase than to that of the dispersed phase, indicating that the bidimensional composites displayed mechanical properties that were related to the properties of each phases in a rather complex manner.
Phase slips in superconducting weak links
Kimmel, Gregory; Glatz, Andreas; Aranson, Igor S.
2017-01-01
Superconducting vortices and phase slips are primary mechanisms of dissipation in superconducting, superfluid, and cold-atom systems. While the dynamics of vortices is fairly well described, phase slips occurring in quasi-one- dimensional superconducting wires still elude understanding. The main reason is that phase slips are strongly nonlinear time-dependent phenomena that cannot be cast in terms of small perturbations of the superconducting state. Here we study phase slips occurring in superconducting weak links. Thanks to partial suppression of superconductivity in weak links, we employ a weakly nonlinear approximation for dynamic phase slips. This approximation is not valid for homogeneous superconducting wires and slabs. Using the numerical solution of the time-dependent Ginzburg-Landau equation and bifurcation analysis of stationary solutions, we show that the onset of phase slips occurs via an infinite period bifurcation, which is manifested in a specific voltage-current dependence. Our analytical results are in good agreement with simulations.
Weak Second Order Explicit Stabilized Methods for Stiff Stochastic Differential Equations
Abdulle, Assyr
2013-01-01
We introduce a new family of explicit integrators for stiff Itô stochastic differential equations (SDEs) of weak order two. These numerical methods belong to the class of one-step stabilized methods with extended stability domains and do not suffer from the step size reduction faced by standard explicit methods. The family is based on the standard second order orthogonal Runge-Kutta-Chebyshev (ROCK2) methods for deterministic problems. The convergence, meansquare, and asymptotic stability properties of the methods are analyzed. Numerical experiments, including applications to nonlinear SDEs and parabolic stochastic partial differential equations are presented and confirm the theoretical results. © 2013 Society for Industrial and Applied Mathematics.
Precision phase estimation based on weak-value amplification
Qiu, Xiaodong; Xie, Linguo; Liu, Xiong; Luo, Lan; Li, Zhaoxue; Zhang, Zhiyou; Du, Jinglei
2017-02-01
In this letter, we propose a precision method for phase estimation based on the weak-value amplification (WVA) technique using a monochromatic light source. The anomalous WVA significantly suppresses the technical noise with respect to the intensity difference signal induced by the phase delay when the post-selection procedure comes into play. The phase measured precision of this method is proportional to the weak-value of a polarization operator in the experimental range. Our results compete well with the wide spectrum light phase weak measurements and outperform the standard homodyne phase detection technique.
Forearm Flexor Muscles in Children with Cerebral Palsy Are Weak, Thin and Stiff
Eva Pontén
2017-04-01
Full Text Available Children with cerebral palsy (CP often develop reduced passive range of motion with age. The determining factor underlying this process is believed to be progressive development of contracture in skeletal muscle that likely changes the biomechanics of the joints. Consequently, to identify the underlying mechanisms, we modeled the mechanical characteristics of the forearm flexors acting across the wrist joint. We investigated skeletal muscle strength (Grippit® and passive stiffness and viscosity of the forearm flexors in 15 typically developing (TD children (10 boys/5 girls, mean age 12 years, range 8–18 yrs and nine children with CP Nine children (6 boys/3 girls, mean age 11 ± 3 years (yrs, range 7–15 yrs using the NeuroFlexor® apparatus. The muscle stiffness we estimate and report is the instantaneous mechanical response of the tissue that is independent of reflex activity. Furthermore, we assessed cross-sectional area of the flexor carpi radialis (FCR muscle using ultrasound. Age and body weight did not differ significantly between the two groups. Children with CP had a significantly weaker (−65%, p < 0.01 grip and had smaller cross-sectional area (−43%, p < 0.01 of the FCR muscle. Passive stiffness of the forearm muscles in children with CP was increased 2-fold (p < 0.05 whereas viscosity did not differ significantly between CP and TD children. FCR cross-sectional area correlated to age (R2 = 0.58, p < 0.01, body weight (R2 = 0.92, p < 0.0001 and grip strength (R2 = 0.82, p < 0.0001 in TD children but only to grip strength (R2 = 0.60, p < 0.05 in children with CP. We conclude that children with CP have weaker, thinner, and stiffer forearm flexors as compared to typically developing children.
Temporally modulated phase retrieval method for weak temporal phase measurement of laser pulses
Qiao, Zhi; Wang, Xiaochao; Jing, Yuanyuan; Fan, Wei; Lin, Zunqi
2016-01-01
The measurement of weak temporal phase for picosecond and nanosecond laser pulses is important but quite difficult. We propose a simple iterative algorithm, which is based on a temporally movable phase modulation process, to retrieve the weak temporal phase of laser pulses. This unambiguous method can achieve a high accuracy and simultaneously measure the weak temporal phase and temporal profile of pulses, which are almost transform-limited. Detailed analysis shows that this iterative method has valuable potential applications in the characterization of pulses with weak temporal phase.
The effect of chain stiffness on the phase behaviour of isolated homopolymers
Doye, J.P.K.; Frenkel, D.
1998-01-01
We have studied the thermodynamics of isolated homopolymer chains of varying stiffness using a lattice model. A complex phase behaviour is found; phases include chain-folded ‘‘crystalline’’ structures, the disordered globule and the coil. It is found, in agreement with recent theoretical calculation
Enhancing Weak-Signal Carrier Phase Tracking in GNSS Receivers
James T. Curran
2015-01-01
Full Text Available Examining the performance of the GNSS PLL, this paper presents novel results describing the statistical properties of four popular phase estimators under both strong- and weak-signal conditions when subject to thermal noise, deterministic dynamics, and typical pedestrian motion. Design routines are developed which employ these results to enhance weak-signal performance of the PLL in terms of transient response, steady-state errors, and cycle-slips. By examining both single and data-pilot signals, it is shown that appropriate design and tuning of the PLL can significantly enhance tracking performance, in particular when used for pedestrian applications.
Estimation of quasi-stiffness of the human hip in the stance phase of walking.
Kamran Shamaei
Full Text Available This work presents a framework for selection of subject-specific quasi-stiffness of hip orthoses and exoskeletons, and other devices that are intended to emulate the biological performance of this joint during walking. The hip joint exhibits linear moment-angular excursion behavior in both the extension and flexion stages of the resilient loading-unloading phase that consists of terminal stance and initial swing phases. Here, we establish statistical models that can closely estimate the slope of linear fits to the moment-angle graph of the hip in this phase, termed as the quasi-stiffness of the hip. Employing an inverse dynamics analysis, we identify a series of parameters that can capture the nearly linear hip quasi-stiffnesses in the resilient loading phase. We then employ regression analysis on experimental moment-angle data of 216 gait trials across 26 human adults walking over a wide range of gait speeds (0.75-2.63 m/s to obtain a set of general-form statistical models that estimate the hip quasi-stiffnesses using body weight and height, gait speed, and hip excursion. We show that the general-form models can closely estimate the hip quasi-stiffness in the extension (R(2 = 92% and flexion portions (R(2 = 89% of the resilient loading phase of the gait. We further simplify the general-form models and present a set of stature-based models that can estimate the hip quasi-stiffness for the preferred gait speed using only body weight and height with an average error of 27% for the extension stage and 37% for the flexion stage.
Weak-signal Phase Calibration Strategies for Large DSN Arrays
Jones, Dayton L.
2005-01-01
The NASA Deep Space Network (DSN) is studying arrays of large numbers of small, mass-produced radio antennas as a cost-effective way to increase downlink sensitivity and data rates for future missions. An important issue for the operation of large arrays is the accuracy with which signals from hundreds of small antennas can be combined. This is particularly true at Ka band (32 GHz) where atmospheric phase variations can be large and rapidly changing. A number of algorithms exist to correct the phases of signals from individual antennas in the case where a spacecraft signal provides a useful signal-to-noise ratio (SNR) on time scales shorter than the atmospheric coherence time. However, for very weak spacecraft signals it will be necessary to rely on background natural radio sources to maintain array phasing. Very weak signals could result from a spacecraft emergency or by design, such as direct-to-Earth data transmissions from distant planetary atmospheric or surface probes using only low gain antennas. This paper considers the parameter space where external real-time phase calibration will be necessary, and what this requires in terms of array configuration and signal processing. The inherent limitations of this technique are also discussed.
Dasbiswas, K.; Majkut, S.; Discher, D. E.; Safran, Samuel A.
2015-01-01
Recent experiments show that both striation, an indication of the structural registry in muscle fibres, as well as the contractile strains produced by beating cardiac muscle cells can be optimized by substrate stiffness. Here we show theoretically how the substrate rigidity dependence of the registry data can be mapped onto that of the strain measurements. We express the elasticity-mediated structural registry as a phase-order parameter using a statistical physics approach that takes the noise and disorder inherent in biological systems into account. By assuming that structurally registered myofibrils also tend to beat in phase, we explain the observed dependence of both striation and strain measurements of cardiomyocytes on substrate stiffness in a unified manner. The agreement of our ideas with experiment suggests that the correlated beating of heart cells may be limited by the structural order of the myofibrils, which in turn is regulated by their elastic environment.
Dark Matter Decay between Phase Transitions at the Weak Scale
Baker, Michael J.; Kopp, Joachim
2017-08-01
We propose a new alternative to the weakly interacting massive particle paradigm for dark matter. Rather than being determined by thermal freeze-out, the dark matter abundance in this scenario is set by dark matter decay, which is allowed for a limited amount of time just before the electroweak phase transition. More specifically, we consider fermionic singlet dark matter particles coupled weakly to a scalar mediator S3 and to auxiliary dark sector fields, charged under the standard model gauge groups. Dark matter freezes out while still relativistic, so its abundance is initially very large. As the Universe cools down, the scalar mediator develops a vacuum expectation value (VEV), which breaks the symmetry that stabilizes dark matter. This allows dark matter to mix with charged fermions and decay. During this epoch, the dark matter abundance is reduced to give the value observed today. Later, the SM Higgs field also develops a VEV, which feeds back into the S3 potential and restores the dark sector symmetry. In a concrete model we show that this "VEV flip-flop" scenario is phenomenologically successful in the most interesting regions of its parameter space. We also comment on detection prospects at the LHC and elsewhere.
Weak intermolecular interactions in gas-phase NMR
Garbacz, Piotr; Jackowski, Karol; Moszynski, Robert; Jaszunski, Michal
2011-01-01
Gas-phase NMR spectra demonstrating the effect of weak intermolecular forces on the NMR shielding constants of the interacting species are reported. We analyse the interaction of the molecular hydrogen isotopomers with He, Ne, and Ar, and the interaction in the He-CO_2 dimer. The same effects are studied for all these systems in the ab initio calculations. The comparison of the experimental and computed shielding constants is shown to depend strongly on the treatment of the bulk susceptibility effects, which determine in practice the pressure dependence of the experimental values. Best agreement of the results is obtained when the bulk susceptibility correction in rare gas solvents is evaluated from the analysis of the He-rare gas interactions, and when the shielding of deuterium in D_2-rare gas systems is considered.
Fang, Chen; Yu, Yang; Li, Qin-Zheng; Zeng, Guihua
2015-01-01
We derive a general theory for the joint weak measurement with arbitrary postselection and employ it in the time-delay measurement. Especially, we study two special cases, i.e., the balanced and unbalanced postselection regimes, and present an experiment to verify the theoretical results. The experimental results show that under similar conditions, the signal-to-noise ratio of using joint weak measurement scheme remains higher than 12 dB when the measured time-delay is smaller the ultimate precision limit of the weak-value amplification scheme. Moreover, the joint weak measurement scheme is robust to the misalignment errors and the wavelength-dependency of optical components, which indicates its advantage of improving the measurement precision with convenient laboratory equipments.
Estimation of quasi-stiffness and propulsive work of the human ankle in the stance phase of walking.
Shamaei, Kamran; Sawicki, Gregory S; Dollar, Aaron M
2013-01-01
Characterizing the quasi-stiffness and work of lower extremity joints is critical for evaluating human locomotion and designing assistive devices such as prostheses and orthoses intended to emulate the biological behavior of human legs. This work aims to establish statistical models that allow us to predict the ankle quasi-stiffness and net mechanical work for adults walking on level ground. During the stance phase of walking, the ankle joint propels the body through three distinctive phases of nearly constant stiffness known as the quasi-stiffness of each phase. Using a generic equation for the ankle moment obtained through an inverse dynamics analysis, we identify key independent parameters needed to predict ankle quasi-stiffness and propulsive work and also the functional form of each correlation. These parameters include gait speed, ankle excursion, and subject height and weight. Based on the identified form of the correlation and key variables, we applied linear regression on experimental walking data for 216 gait trials across 26 subjects (speeds from 0.75-2.63 m/s) to obtain statistical models of varying complexity. The most general forms of the statistical models include all the key parameters and have an R(2) of 75% to 81% in the prediction of the ankle quasi-stiffnesses and propulsive work. The most specific models include only subject height and weight and could predict the ankle quasi-stiffnesses and work for optimal walking speed with average error of 13% to 30%. We discuss how these models provide a useful framework and foundation for designing subject- and gait-specific prosthetic and exoskeletal devices designed to emulate biological ankle function during level ground walking.
Estimation of quasi-stiffness and propulsive work of the human ankle in the stance phase of walking.
Kamran Shamaei
Full Text Available Characterizing the quasi-stiffness and work of lower extremity joints is critical for evaluating human locomotion and designing assistive devices such as prostheses and orthoses intended to emulate the biological behavior of human legs. This work aims to establish statistical models that allow us to predict the ankle quasi-stiffness and net mechanical work for adults walking on level ground. During the stance phase of walking, the ankle joint propels the body through three distinctive phases of nearly constant stiffness known as the quasi-stiffness of each phase. Using a generic equation for the ankle moment obtained through an inverse dynamics analysis, we identify key independent parameters needed to predict ankle quasi-stiffness and propulsive work and also the functional form of each correlation. These parameters include gait speed, ankle excursion, and subject height and weight. Based on the identified form of the correlation and key variables, we applied linear regression on experimental walking data for 216 gait trials across 26 subjects (speeds from 0.75-2.63 m/s to obtain statistical models of varying complexity. The most general forms of the statistical models include all the key parameters and have an R(2 of 75% to 81% in the prediction of the ankle quasi-stiffnesses and propulsive work. The most specific models include only subject height and weight and could predict the ankle quasi-stiffnesses and work for optimal walking speed with average error of 13% to 30%. We discuss how these models provide a useful framework and foundation for designing subject- and gait-specific prosthetic and exoskeletal devices designed to emulate biological ankle function during level ground walking.
Estimation of quasi-stiffness of the human knee in the stance phase of walking.
Kamran Shamaei
Full Text Available Biomechanical data characterizing the quasi-stiffness of lower-limb joints during human locomotion is limited. Understanding joint stiffness is critical for evaluating gait function and designing devices such as prostheses and orthoses intended to emulate biological properties of human legs. The knee joint moment-angle relationship is approximately linear in the flexion and extension stages of stance, exhibiting nearly constant stiffnesses, known as the quasi-stiffnesses of each stage. Using a generalized inverse dynamics analysis approach, we identify the key independent variables needed to predict knee quasi-stiffness during walking, including gait speed, knee excursion, and subject height and weight. Then, based on the identified key variables, we used experimental walking data for 136 conditions (speeds of 0.75-2.63 m/s across 14 subjects to obtain best fit linear regressions for a set of general models, which were further simplified for the optimal gait speed. We found R(2 > 86% for the most general models of knee quasi-stiffnesses for the flexion and extension stages of stance. With only subject height and weight, we could predict knee quasi-stiffness for preferred walking speed with average error of 9% with only one outlier. These results provide a useful framework and foundation for selecting subject-specific stiffness for prosthetic and exoskeletal devices designed to emulate biological knee function during walking.
Khogali, Shiemaa; Lucas, Brooke; Ammar, Tarek; Dejong, Danica; Barbalinardo, Michael; Hayward, Lawrence J; Renaud, Jean-Marc
2015-12-01
The mechanisms responsible for the onset and progressive worsening of episodic muscle stiffness and weakness in hyperkalemic periodic paralysis (HyperKPP) are not fully understood. Using a knock-in HyperKPP mouse model harboring the M1592V NaV1.4 channel mutant, we interrogated changes in physiological defects during the first year, including tetrodotoxin-sensitive Na(+) influx, hindlimb electromyographic (EMG) activity and immobility, muscle weakness induced by elevated [K(+)]e, myofiber-type composition, and myofiber damage. In situ EMG activity was greater in HyperKPP than wild-type gastrocnemius, whereas spontaneous muscle contractions were observed in vitro. We suggest that both the greater EMG activity and spontaneous contractions are related to periods of hyperexcitability during which fibers generate action potentials by themselves in the absence of any stimulation and that these periods are the cause of the muscle stiffness reported by patients. HyperKPP muscles had a greater sensitivity to the K(+)-induced force depression than wild-type muscles. So, an increased interstitial K(+) concentration locally near subsets of myofibers as a result of the hyperexcitability likely produced partial loss of force rather than complete paralysis. NaV1.4 channel protein content reached adult level by 3 weeks postnatal in both wild type and HyperKPP and apparent symptoms did not worsen after the first month of age suggesting (i) that the phenotypic behavior of M1592V HyperKPP muscles results from defective function of mutant NaV1.4 channels rather than other changes in protein expression after the first month and (ii) that the lag in onset during the first decade and the progression of human HyperKPP symptoms during adolescence are a function of NaV1.4 channel content. © 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.
Weak phases from B decays to kaons and charged pions
Dighe, Amol S.; Gronau, Michael; Rosner, Jonathan L.
1996-09-01
Phases of elements of the Cabibbo-Kobayashi-Maskawa (CKM) matrix can be obtained using decays of B mesons to π+π-, π+/-K-/+, and π+K0 or π-K¯0. For B0 or B¯0-->π+π-, one identifies the flavor of the neutral B meson at time of production and studies the time dependence of the decay rate. The other processes are self-tagging and only their rates need to be measured. By assuming flavor SU(3) symmetry and first-order SU(3) breaking, one can separately determine the phases γ≡Arg V*ub and α=π-β-γ, where β≡Arg V*td. Special cases include the vanishing of strong interaction phase differences between amplitudes, the possibility of recovering partial information when π+π- and π+/-K-/+ decays cannot be distinguished from one another, and the use of a correlation between γ and α in the region of allowed parameters.
Weak phases from B decays to kaons and charged pions
Dighe, A S; Rosner, Jonathan L; Dighe, Amol S; Gronau, Michael; Rosner, Jonathan L
1996-01-01
Phases of elements of the Cabibbo-Kobayashi-Maskawa (CKM) matrix can be obtained using decays of B mesons to \\pi^+ \\pi^-, \\pi^\\pm K^\\mp, and \\pi^+ K^0 or \\pi^- \\overline{K}^0. For B^0~{\\rm or}~ \\overline{B}^0 \\to \\pi^+ \\pi^-, one identifies the flavor of the neutral B meson at time of production and studies the time-dependence of the decay rate. The other processes are self-tagging and only their rates need be measured. By assuming flavor SU(3) symmetry and first-order SU(3) breaking, one can separately determine the phases \\gamma \\equiv {\\rm Arg}~V_{ub}^* and \\alpha = \\pi - \\beta - \\gamma, where \\beta \\equiv {\\rm Arg}~V_{td}^*. Special cases include the vanishing of strong interaction phase differences between amplitudes, the possibility of recovering partial information when \\pi^+ \\pi^- and \\pi^\\pm K^\\mp decays cannot be distinguished from one another, and the use of a correlation between \\gamma and \\alpha in the region of allowed parameters.
Detection of phase randomly distributed weak transient signal using chaos
无
2005-01-01
In practical communication and radar system s, the phase of the received signal is random, the arrival time is unknown, the lasting time is limited and the SNR is often very low. In order to realize the detection of the signal, the method of using a group of nonlinear differential equations is presented. The theory of this chaos-based detection is analyzed. Computer simulation indicates that the shortest lasting time of the transient signal that can be detected out is 12 periods, the detection error of arrival time is less than 7/8 signal's period, the detection characteristics are got using Monte-Carlo simulation.
Weak Phases From B Decays to Kaons and Charged Pions
1996-01-01
Phases of elements of the Cabibbo-Kobayashi-Maskawa (CKM) matrix can be obtained using decays of $B$ mesons to $\\pi^+ \\pi^-$, $\\pi^\\pm K^\\mp$, and $\\pi^+ K^0$ or $\\pi^- \\overline{K}^0$. For $B^0~{\\rm or}~ \\overline{B}^0 \\to \\pi^+ \\pi^-$, one identifies the flavor of the neutral $B$ meson at time of production and studies the time-dependence of the decay rate. The other processes are self-tagging and only their rates need be measured. By assuming flavor SU(3) symmetry and first-order SU(3) bre...
Efficient integration of stiff kinetics with phase change detection for reactive reservoir processes
Kristensen, Morten Rode; Gerritsen, Margot G.; Thomsen, Per Grove;
2007-01-01
We propose the use of implicit one-step Explicit Singly Diagonal Implicit Runge-Kutta (ESDIRK) methods for integration of the stiff kinetics in reactive, compositional and thermal processes that are solved using operator-splitting type approaches. To facilitate the algorithmic development we...
Phase-locking behavior in a high-frequency gymnotiform weakly electric fish, Adontosternarchus.
Kawasaki, Masashi; Leonard, John
2017-02-01
An apteronotid weakly electric fish, Adontosternarchus, emits high-frequency electric organ discharges (700-1500 Hz) which are stable in frequency if no other fish or artificial signals are present. When encountered with an artificial signal of higher frequency than the fish's discharge, the fish raised its discharge frequency and eventually matched its own frequency to that of the artificial signal. At this moment, phase locking was observed, where the timing of the fish's discharge was precisely stabilized at a particular phase of the artificial signal over a long period of time (up to minutes) with microsecond precision. Analyses of the phase-locking behaviors revealed that the phase values of the artificial stimulus at which the fish stabilizes the phase of its own discharge (called lock-in phases) have three populations between -180° and +180°. During the frequency rise and the phase-locking behavior, the electrosensory system is exposed to the mixture of feedback signals from its electric organ discharges and the artificial signal. Since the signal mixture modulates in both amplitude and phase, we explored whether amplitude or phase information participated in driving the phase-locking behavior, using a numerical model. The model which incorporates only amplitude information well predicted the three populations of lock-in phases. When phase information was removed from the electrosensory stimulus, phase-locking behavior was still observed. These results suggest that phase-locking behavior of Adontosternarchus requires amplitude information but not phase information available in the electrosensory stimulus.
A WEAKLY NONLINEAR WATER WAVE MODEL TAKING INTO ACCOUNT DISPERSION OF WAVE PHASE VELOCITY
李瑞杰; 李东永
2002-01-01
This paper presents a weakly nonlinear water wave model using a mild slope equation and a new explicit formulation which takes into account dispersion of wave phase velocity, approximates Hedges' (1987) nonlinear dispersion relationship, and accords well with the original empirical formula. Comparison of the calculating results with those obtained from the experimental data and those obtained from linear wave theory showed that the present water wave model considering the dispersion of phase velocity is rational and in good agreement with experiment data.
Coherent Control of Photofragment Distributions Using Laser Phase Modulation in the Weak-Field Limit
Garcia-Vela, Alberto; Henriksen, Niels Engholm
2015-01-01
The possibility of quantum interference control of the final state distributions of photodissociation fragments by means of pure phase modulation of the pump laser pulse in the weak-field regime is demonstrated theoretically for the first time. The specific application involves realistic wave pac...
Phase reduction of weakly perturbed limit cycle oscillations in time-delay systems
Novičenko, V.; Pyragas, K.
2012-06-01
The phase reduction method is applied to a general class of weakly perturbed time-delay systems exhibiting periodic oscillations. The adjoint equation with an appropriate initial condition for the infinitesimal phase response curve of a time-delay system is derived. The method is demonstrated numerically for the Mackey-Glass equation as well as for a chaotic Rössler system subject to a delayed feedback control (DFC). We show that the profile of the phase response curve of a periodic orbit stabilized by the DFC algorithm does not depend on the control matrix. This property is universal and holds for any dynamical system subject to the DFC.
Modulated magnetic phase of structurally heterogeneous easy-plane weak ferromagnets
Dzhuraev, D. R.; Niyazov, L. N.; Sokolov, B. Yu.
2016-06-01
The modulated magnetic phase of a structurally heterogeneous easy-plane weak ferromagnet is considered in terms of the thermodynamic Landau theory of phase transitions. The temperature and field dependences of the main magnetic order modulation parameters are determined. The results obtained are compared with the experimental data obtained for the orientational phase transition into a modulated magnetic state that occurs in hematite and iron borate crystals doped with diamagnetic ions to create structural heterogeneity. The proposed theoretical model is shown to describe the entire set of experimental results consistently with some exceptions.
Weak Finite—Size Dependence of Velocity and Strong Phase Dependence of Central Charge
LINZhi－Bin; ZHANGJun; 等
2002-01-01
We study the finite-size scaling behavior of velocity and central charge for different coupling constants and different phases in (1+1)-dimensional lattice model in very short chains.Using XXZ spin 1/2 chains with 15 or fewer sites,we demonstrate the weak finite-size dependence of spinon velocity for any magnitude of coupling strength Jz and the strong phase dependence of central charge.This behavior of velocity and central charge in different coupling constants and different phases gives a method to determine phase transitions of (1+1)-dimensional models.This method is simple and efficient by utilizing only the ground state energy of very short finite-size chains.It is also general and powerfur for various one-dimensional lattice models and it uncovers eventhe weakest berezinski-Kosterlitz-Thouless phase transitions.
Wang, Ting; Zhu, Yi-Chen; Sun, Zhi-Xuan; Wu, Li-Guang
2015-02-01
Photodegradation of pollutions by TiO2 under irradiation of weak UV and visible lights was one of the key points to expand the application of heterogeneous photocatalysis. Based on the adsorption phase synthesis, N doping and co-doping with N and Fe2O3 were employed to prepare TiO2 multi composite photocatalysts. The activity of these photocatalyts was evaluated by photodegradation of methyl-orange illuminated under weak UV and visible lights. Via UV-Vis diffuse reflectance spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy and photoluminescence spectra, the effects on the light absorption and visible response expansion of catalysts caused by different conditions were explored, such as sintering temperature, doping content of N and co-doping. Followed that, the changes in the photocatalytic activities were studied under the irradiation of weak light. The results showed that, N doping could enhance the light absorption of the catalysts, thus significantly enhanced their photocatalytic activity illuminated under UV weak light. All N-doped photocatalysts had a higher activity than the commercial available P25 photocatalyst. The visible response of catalysts was expanded little caused by N doping, thereby most catalysts doped by single N element had no activity illuminated by weak visible light. Only the catalyst doped with 5% of N element showed a weak activity after calcined at 900 degrees C . Due to the synergy effects between N doping and Fe2O3 coupling, co-doping did not only enhance the light absorption of the catalysts, but also significantly expanded the visible response of catalysts. So, co-doped catalysts showed a good catalytic activity when excited by weak visible light.
Phase conversion in a weakly first-order quark-hadron transition
Bessa, A; Mintz, B W
2008-01-01
We investigate the process of phase conversion in a thermally-driven {\\it weakly} first-order quark-hadron transition. This scenario is physically appealing even if the nature of this transition in equilibrium proves to be a smooth crossover for vanishing baryonic chemical potential. We construct an effective potential by combining the equation of state obtained within Lattice QCD for the partonic sector with that of a gas of resonances in the hadronic phase, and present numerical results on bubble profiles, nucleation rates and time evolution, including the effects from reheating on the dynamics for different expansion scenarios. Our findings confirm the standard picture of a cosmological first-order transition, in which the process of phase conversion is entirely dominated by nucleation, also in the case of a weakly first-order transition. On the other hand, we show that, even for expansion rates much lower than those expected in high-energy heavy ion collisions, nucleation is very unlikely, indicating that...
Weak Coupling Phase Structureof the Abelian Higgs Model at Finite Temperature
Jakovác, A
1993-01-01
Using the 1-loop reduced 3D action of the Abelian Higgs-model we discuss the order of its finite temperature phase transition. A two-variable saddle point approximation is proposed for the evaluation of the effective potential. The strength of the first order case scales like \\sim e^{3-6}. Analytic asymptotic weak coupling and numerical small coupling solutions are compared with special emphasis on the cancellation of divergences. (Figures are not included, can be sent upon request from jako@hercules.elte.hu .)
Weak phase alpha from B^0-> a_1^{+-}(1260) pi^{-+}
Gronau, M
2006-01-01
Quasi two-body decays B^0(t)-> a_1^{+-}(1260) pi^{-+} identified by four charged pions determine a phase alpha_eff, which is equal to the weak phase alpha in the limit of vanishing penguin amplitudes. Applying flavor SU(3) to these decays and to B->a_1 K and B->K_1 pi, with K_1 an admixture of K_1(1270) and K_1(1400), we derive expressions providing bounds on alpha-alpha_{eff}. Higher precision in alpha may be achieved by an overall fit to a complete set of SU(3) related measurements. A method is sketched applying isospin symmetry to time-dependent invariant mass distributions in B->pi^+ pi^- pi^0 pi^0.
Phase diagram of the t U2 Hamiltonian of the weak coupling Hubbard model
Yanagisawa, Takashi
2008-02-01
We determine the symmetry of Cooper pairs, on the basis of the perturbation theory in terms of the Coulomb interaction U, for the two-dimensional Hubbard model on the square lattice. The phase diagram is investigated in detail. The Hubbard model for small U is mapped on to an effective Hamiltonian with the attractive interaction using the canonical transformation: Heff = eSHe-S. The gap equation of the weak coupling formulation is solved without numerical ambiguity to determine the symmetry of Cooper pairs. The superconducting gap crucially depends on the position of the van Hove singularity. We show the phase diagram in the plane of the electron filling ne and the next nearest-neighbor transfer t'. The d-wave pairing is dominant for the square lattice in a wide range of ne and t'. The d-wave pairing is also stable for the square lattice with anisotropic t'. The three-band d-p model is also investigated, for which the d-wave pairing is stable in a wide range of ne and tpp (the transfer between neighboring oxygen atoms). In the weak coupling analysis, the second-neighbor transfer parameter -t' could not be so large so that the optimum doping rate is in the range of 0.8 < ne < 0.85.
Pratt, D. T.
1984-01-01
Conventional algorithms for the numerical integration of ordinary differential equations (ODEs) are based on the use of polynomial functions as interpolants. However, the exact solutions of stiff ODEs behave like decaying exponential functions, which are poorly approximated by polynomials. An obvious choice of interpolant are the exponential functions themselves, or their low-order diagonal Pade (rational function) approximants. A number of explicit, A-stable, integration algorithms were derived from the use of a three-parameter exponential function as interpolant, and their relationship to low-order, polynomial-based and rational-function-based implicit and explicit methods were shown by examining their low-order diagonal Pade approximants. A robust implicit formula was derived by exponential fitting the trapezoidal rule. Application of these algorithms to integration of the ODEs governing homogenous, gas-phase chemical kinetics was demonstrated in a developmental code CREK1D, which compares favorably with the Gear-Hindmarsh code LSODE in spite of the use of a primitive stepsize control strategy.
Soares, Ruben R G; Azevedo, Ana M; Van Alstine, James M; Aires-Barros, M Raquel
2015-08-01
For half a century aqueous two-phase systems (ATPSs) have been applied for the extraction and purification of biomolecules. In spite of their simplicity, selectivity, and relatively low cost they have not been significantly employed for industrial scale bioprocessing. Recently their ability to be readily scaled and interface easily in single-use, flexible biomanufacturing has led to industrial re-evaluation of ATPSs. The purpose of this review is to perform a SWOT analysis that includes a discussion of: (i) strengths of ATPS partitioning as an effective and simple platform for biomolecule purification; (ii) weaknesses of ATPS partitioning in regard to intrinsic problems and possible solutions; (iii) opportunities related to biotechnological challenges that ATPS partitioning may solve; and (iv) threats related to alternative techniques that may compete with ATPS in performance, economic benefits, scale up and reliability. This approach provides insight into the current status of ATPS as a bioprocessing technique and it can be concluded that most of the perceived weakness towards industrial implementation have now been largely overcome, thus paving the way for opportunities in fermentation feed clarification, integration in multi-stage operations and in single-step purification processes.
The Vev Flip-Flop: Dark Matter Decay between Weak Scale Phase Transitions
Baker, Michael J
2016-01-01
We propose a new alternative to the Weakly Interacting Massive Particle (WIMP) paradigm for dark matter. Rather than being determined by thermal freeze-out, the dark matter abundance in this scenario is set by dark matter decay, which is allowed for a limited amount of time just before the electroweak phase transition. More specifically, we consider dark matter particles coupled weakly to a scalar mediator $S$ and a SM fermion. Dark matter freezes out while still relativistic, so its abundance is initially very large. As the Universe cools down, the scalar mediator develops a vacuum expectation value (vev), which breaks the $\\mathbb{Z}_2$ symmetry that stabilises dark matter. This allows dark matter to mix with SM particles and decay. During this epoch, the dark matter abundance is reduced to give the value observed today. Later, the SM Higgs field also develops a vev, which feeds back into the $S$ potential and restores the $\\mathbb{Z}_2$ symmetry. In a concrete model we show that this "vev flip-flop" scenar...
On the convergence of the weakly compressible sharp-interface method for two-phase flows
Schranner, Felix S.; Hu, Xiangyu; Adams, Nikolaus A.
2016-11-01
A weakly compressible sharp-interface framework for two-phase flows is presented. Special emphasis is on investigating its convergence properties. For this purpose a well-defined set of benchmark configurations is introduced. These may serve as future references for the verification of sharp-interface methods. Global mass and momentum conservation is ensured by the conservative sharp-interface method. Viscous and capillary stresses are considered directly at the interface. A low-dissipation weakly compressible Roe Riemann solver, in combination with a 5th-order WENO scheme, leads to high spatial accuracy. A wavelet-based adaptive multi-resolution approach permits to combine computational efficiency with physical consistency. The first test configuration is a Rayleigh-Taylor instability at moderate Reynolds number and infinite Eötvös number. A second group of benchmark cases are isolated air bubbles rising in water at high Eötvös numbers, and low to high Reynolds numbers. With these test cases, three distinct types of complex interface evolution, which are typical for a wide range of industrial applications, are realized.
Theoretical study on phase conjugation in weakly injected vertical-cavity surface-emitting lasers
Zhang Wei-Li; Pan Wei; Luo Bin; Li Xiao-Feng; Zou Xi-Hua; Wang Meng-Yao
2008-01-01
This paper gives a detailed theoretical investigation on phase conjugation induced by nearly degenerate fourwave mixing in single mode vertical-cavity surface-emitting lasers (VCSELs) with~weak optical injection.Considering VCSELs that can work in linearly polarized or elliptically polarized states,it derives the theoretical expression of the conjugated field by small signal analysis based on the vectoral rate equations--the spin-flip model.For linearly polarized state,VCSELs show similar conjugate spectra to edge-emitting semiconductor lasers.For the eUiptically polarized state,dichroism and birefringence parameters as well as the spin-flip rate can change the conjugate spectra.Especially,when frequency detuning of the probe and pump waves is between the positive and negative relaxation oscillation frequency,changes are evident.For specific values of parameters,conjugate efficiency between 20 dB to 40 dB are obtained.
Torrents, Genís; Illa, Xavier; Vives, Eduard; Planes, Antoni
2017-01-01
A simple model for the growth of elongated domains (needle-like) during a martensitic phase transition is presented. The model is purely geometric and the only interactions are due to the sequentiality of the kinetic problem and to the excluded volume, since domains cannot retransform back to the original phase. Despite this very simple interaction, numerical simulations show that the final observed microstructure can be described as being a consequence of dipolar-like interactions. The model is analytically solved in 2D for the case in which two symmetry related domains can grow in the horizontal and vertical directions. It is remarkable that the solution is analytic both for a finite system of size L ×L and in the thermodynamic limit L →∞ , where the elongated domains become lines. Results prove the existence of criticality, i.e., that the domain sizes observed in the final microstructure show a power-law distribution characterized by a critical exponent. The exponent, nevertheless, depends on the relative probabilities of the different equivalent variants. The results provide a plausible explanation of the weak universality of the critical exponents measured during martensitic transformations in metallic alloys. Experimental exponents show a monotonous dependence with the number of equivalent variants that grow during the transition.
Gaitan, F.; Shenoy, S.R. [International Center for Theoretical Physics, P. O. Box 586, Miramare, 34100 Trieste (Italy)
1996-06-01
We examine the consequences of Berry{close_quote}s phase for the dynamics of Josephson junctions and junction arrays in which moving vortices are present. For both a large annular Josephson junction and a 2D junction array, Berry{close_quote}s phase produces a new current drive in the superconducting phase dynamics of these weak link systems. This Berry phase effect is shown to be physically inequivalent to a known effect in junction arrays associated with the Aharonov-Casher phase. {copyright} {ital 1996 The American Physical Society.}
Controlling Penguins : an estimate of penguin topologies contributing to the weak phase $\\phi$s.
AUTHOR|(INSPIRE)INSPIRE-00392811; Koppenburg, P.
The main focus of the current thesis is to provide the required ingredients for a high precision measurement of the weak phase φs. The latter is an important parameter related to CP violation, which, as explained throughout the current chapter, is related to the matter-antimatter asymmetry in the universe. Measuring φs enables one to look for de- viations from the established theory of elementary particles. Given the state of the art measurement of φs [1], it is clear that in order to probe potential deviations, φs needs to be measured with increased precision. However, entering this high precision regime one finds out that there are sub-leading contributions that need to be controlled first. Unless this is achieved, a high precision measurement of φs can not provide insight on possible deviations. While measuring φs is based on the analysis of B0s → J/ψφ decays, controlling these sub-leading contributions requires a different decay channel, like B0s → J/ψK∗0, which plays the role of a control ...
Weakly doped InP layers prepared by liquid phase epitaxy using a modulated cooling rate
Krukovskyi, R.; Mykhashchuk, Y.; Kost, Y.; Krukovskyi, S.; Saldan, I.
2017-04-01
Epitaxial structures based on InP are widely used to manufacture a number of devices such as microwave transistors, light-emitting diodes, lasers and Gunn diodes. However, their temporary instability caused by heterogeneity of resistivity along the layer thickness and the influence of various external or internal factors prompts the need for the development of a new reliable technology for their preparation. Weak doping by Yb, Al and Sn together with modulation of the cooling rate applied to prepare InP epitaxial layers is suggested to be adopted within the liquid phase epitaxy (LPE) method. The experimental results confirm the optimized conditions created to get a uniform electron concentration in the active n-InP layer. A sharp profile of electron concentration in the n+-InP(substrate)/n-InP/n+-InP epitaxial structure was observed experimentally at the proposed modulated cooling rate of 0.3 °С-1.5 °С min-1. The proposed technological method can be used to control the electrical and physical properties of InP epitaxial layers to be used in Gunn diodes.
Gao, Xiangwen; Chen, Yuhui; Johnson, Lee; Bruce, Peter G.
2016-08-01
On discharge, the Li-O2 battery can form a Li2O2 film on the cathode surface, leading to low capacities, low rates and early cell death, or it can form Li2O2 particles in solution, leading to high capacities at relatively high rates and avoiding early cell death. Achieving discharge in solution is important and may be encouraged by the use of high donor or acceptor number solvents or salts that dissolve the LiO2 intermediate involved in the formation of Li2O2. However, the characteristics that make high donor or acceptor number solvents good (for example, high polarity) result in them being unstable towards LiO2 or Li2O2. Here we demonstrate that introduction of the additive 2,5-di-tert-butyl-1,4-benzoquinone (DBBQ) promotes solution phase formation of Li2O2 in low-polarity and weakly solvating electrolyte solutions. Importantly, it does so while simultaneously suppressing direct reduction to Li2O2 on the cathode surface, which would otherwise lead to Li2O2 film growth and premature cell death. It also halves the overpotential during discharge, increases the capacity 80- to 100-fold and enables rates >1 mA cmareal-2 for cathodes with capacities of >4 mAh cmareal-2. The DBBQ additive operates by a new mechanism that avoids the reactive LiO2 intermediate in solution.
García-Vela, Alberto; Henriksen, Niels Engholm
2016-01-01
The role played by quantum interference in the laser phase modulation coherent control of photofragment distributions in the weak-field regime is investigated in detail in this work. The specific application involves realistic wave packet calculations of the transient vibrational populations of t...
Weldon, W. F.; Bacon, J. L.; Weeks, D. A.; Zowarka, R. C., Jr.
1991-01-01
Stiff guns have been operated with both plasma and solid armatures. A performance gain was seen in the plasma railgun as stiffness was increased. A stiff gun will help to maintain the bore shape and preserve the integrity of the seam between rail and insulator under the extreme asymmetric loads sustained during high-pressure operation. The hydraulically preloaded moly and ceramic gun has been fired six times at pressures as high as 87 ksi, and the bore still holds roughing vacuum up to two hours after the test. The elimination of seam leakage helps control bore erosion associated with plasma reconstitution from the rail and plasma perturbation that might result in loss-initiating instabilities. Reduced rail deflection allows solid and transitioning armatures to track the bore surface. An analysis of the strain energy associated with the deflection of the railgun structure is presented, and this mechanism is found to be a small fraction of the energy associated with armature loss and the rail resistive loss.
Five-phase induction motor drive for weak and remote grid system
Administrator
, LIBYA ... three-phase so the supply to multi-phase motors is invariably given from power electronic converters. Thus the paper ...... Printed Circuit Boards general. 6 ... flexible 3rd harmonic current injection for high specific torque, Conf. Rec.
Strength and weakness of phase I to IV trials, with an emphasis on translational aspects
Lønning, Per Eystein
2008-01-01
Although phase I to III trials represent the standard for introducing new drugs to clinical therapy, there has been increasing demand for translational research in oncology over the past decade. Thus, for most novel therapies such as 'targeted agents', a critical aspect for drug development in oncology has been to select the right patients for therapy. Translational research plays a pivotal role, not only in phase II trials but also in phase I and III and even in phase IV trials. The importan...
Avolio, Alberto
2013-04-01
Stiffness of large arteries has been long recognized as a significant determinant of pulse pressure. However, it is only in recent decades, with the accumulation of longitudinal data from large and varied epidemiological studies of morbidity and mortality associated with cardiovascular disease, that it has emerged as an independent predictor of cardiovascular risk. This has generated substantial interest in investigations related to intrinsic causative and associated factors responsible for the alteration of mechanical properties of the arterial wall, with the aim to uncover specific pathways that could be interrogated to prevent or reverse arterial stiffening. Much has been written on the haemodynamic relevance of arterial stiffness in terms of the quantification of pulsatile relationships of blood pressure and flow in conduit arteries. Indeed, much of this early work regarded blood vessels as passive elastic conduits, with the endothelial layer considered as an inactive lining of the lumen and as an interface to flowing blood. However, recent advances in molecular biology and increased technological sophistication for the detection of low concentrations of biochemical compounds have elucidated the highly important regulatory role of the endothelial cell affecting vascular function. These techniques have enabled research into the interaction of the underlying passive mechanical properties of the arterial wall with the active cellular and molecular processes that regulate the local environment of the load-bearing components. This review addresses these emerging concepts.
Dries, M., E-mail: manuel.dries@kit.edu [Laboratorium fuer Elektronenmikroskopie, Karlsruher Institut fuer Technologie (KIT), D-76128 Karlsruhe (Germany); Schultheiss, K.; Gamm, B. [Laboratorium fuer Elektronenmikroskopie, Karlsruher Institut fuer Technologie (KIT), D-76128 Karlsruhe (Germany); Rosenauer, A. [Institut fuer Festkoerperphysik, Universitaet Bremen, D-28359 Bremen (Germany); Schroeder, R.R. [BioQuant CellNetworks, Universitaet Heidelberg, D-69120 Heidelberg (Germany); Gerthsen, D. [Laboratorium fuer Elektronenmikroskopie, Karlsruher Institut fuer Technologie (KIT), D-76128 Karlsruhe (Germany)
2011-01-15
Transmission electron microscopy phase-contrast images taken by amorphous carbon film-based phase plates are affected by the scattering of electrons within the carbon film causing a modification of the image-wave function. Moreover, image artefacts are produced by non-centrosymmetric phase plate designs such as the Hilbert-phase plate. Various methods are presented to correct phase-contrast images with respect to the scattering of electrons and image artefacts induced by phase plates. The proposed techniques are not restricted to weak-phase objects and linear image formation. Phase-contrast images corrected by the presented methods correspond to those taken by an ideal centrosymmetric, matter-free phase plate and are suitable for object-wave reconstruction. -- Research Highlights: {yields} Object-wave reconstruction by phase plates considering nonlinear image formation. {yields} Requirement of three (five) images in case of Zernike- (Hilbert-) phase plates. {yields} Analytical correction of damping and/or image artefacts induced by phase plates.{yields} Validation by simulation of crystalline silicon.
Ludewig, Ronny; Nietzsche, Sandor; Scriba, Gerhard K E
2011-01-01
A CEC weak cation-exchange monolith has been prepared by in situ polymerization of acrylamide, methylenebisacrylamide and 4-acrylamidobutyric acid in a decanol-dimethylsulfoxide mixture as porogen. The columns were evaluated by SEM and characterized with regard to the separation of diastereomers and α/β-isomers of aspartyl peptides. Column preparation was reproducible as evidenced by comparison of the analyte retention times of several columns prepared simultaneously. Analyte separation was achieved using mobile phases consisting of acidic phosphate buffer and ACN. Under these conditions the peptides migrated due to their electrophoretic mobility but the EOF also contributed as driving force as a function of the pH of the mobile phase due to increasing dissociation of the carboxyl groups of the polymer. Raising the pH of the mobile phase also resulted in deprotonation of the peptides reducing analyte mobility. Due to these mechanisms each pair of diastereomeric peptides displayed the highest resolution at a different pH of the buffer component of the mobile phase. Comparing the weak-cation exchange monolith to an RP monolith and a strong cation-exchange monolith different elution order of some peptide diastereomers was observed, clearly illustrating that interactions with the stationary phase contribute to the CEC separations.
Phase Structure of Weak MgII Absorbers Star Forming Pockets Outside of Galaxies
Charlton, J C; Ding, J; Zonak, S G; Bond, N; Rigby, J R; Charlton, Jane C.; Churchill, Christopher W.; Ding, Jie; Zonak, Stephanie; Bond, Nicholas; Rigby, Jane R.
2001-01-01
A new and mysterious class of object has been revealed by the detection of numerous weak MgII doublets in quasar absorption line spectra. The properties of these objects will be reviewed. They are not in close proximity to luminous galaxies, yet they have metallicities close to the solar value; they are likely to be self-enriched. A significant fraction of the weak MgII absorbers are constrained to be less than 10 parsecs in size, yet they present a large cross-section for absorption, indicating that there are more than a million times more of them than there are luminous galaxies. They could be remnants of Population III star clusters or tracers of supernova remnants in a population of "failed dwarf galaxies" expected in cold dark matter structure formation scenarios.
Weak phases $\\gamma$ and $\\alpha$ from $B^{+}$, or $B^{0}$ and $B_{s}$ decays
Gronau, Michael; Gronau, Michael; Pirjol, Dan
1999-01-01
An improved method is presented for determining the weak angle $\\gamma$ of the unitarity triangle using decay rates for $B^+\\to K\\pi, B^+\\to K^+\\bar K^0$ and $B^+\\to \\pi^+\\eta$ (or $B^0\\to K\\pi$ and $B_s\\to K \\pi$), their CP-conjugate modes and the CP-averaged rate for $B^\\pm\\to\\pi^\\pm\\pi^{0}$. Using SU(3) symmetry, the annihilation (color-suppressed) contribution in $B^+(B^0)\\to K\\pi$ decays is subtracted away. Electroweak penguin effects are included in a model-independent way. The only significant SU(3) breaking effects are accounted for in the factorization approximation of tree amplitudes. The weak angle $\\alpha$ is obtained as a byproduct.
Yang, Dewen; Deng, Yuqun; Teng, Yan; Shi, Yanchao; Wu, Ping; Chen, Changhua
2017-05-01
Phase locking is the key point of coherent power combination, which is very important for the development of high power microwave sources. In this paper, theoretical analysis and particle-in-cell simulations investigate the influence of the diode voltage rise time on phase locking by the priming effect in a weakly resonant relativistic backward wave oscillator (RBWO). When the diode voltage rise time becomes long and the final output frequency remains unchanged, the initial operation frequency may fluctuate around a value which is not equal to the final output frequency. Moreover, this state may last for several nanoseconds and then jumps to the final output frequency, which is very important for phase locking. Besides, it is suggested that, due to the weak resonance of the RF cavity without the electron beam, the microwave signal with frequency which is much lower than the final output frequency is usually excited at the beginning of the starting process. Finally, it is found that, when the injected frequency approaches the frequency of the initial microwave signal, the phase locking by the priming effect in the RBWO with long voltage rise time is noticeably improved, and the starting process becomes more rapid as well. The simulation results agree well with theoretical analysis.
Tiwari, Ashwani K., E-mail: ashwani@iiserkol.ac.in [Indian Institute of Science Education and Research Kolkata, Mohanpur 741 246 (India); Henriksen, Niels E., E-mail: neh@kemi.dtu.dk [Department of Chemistry, Technical University of Denmark, Building 207, DK-2800 Kongens Lyngby (Denmark)
2016-01-07
We demonstrate theoretically that laser-induced coherent quantum interference control of asymptotic states of dissociating molecules is possible, starting from a single vibrational eigenstate, after the interaction with two laser pulses—at a fixed time delay—both operating in the weak-field limit. Thus, phase dependence in the interaction with the second fixed-energy phase-modulated pulse persists after the pulse is over. This is illustrated for the nonadiabatic process: I + Br{sup *}←IBr → I + Br, where the relative yield of excited Br{sup *} can be changed by pure phase modulation. Furthermore, a strong frequency dependence of the branching ratio is observed and related to the re-crossing dynamics of the avoided crossing in the above-mentioned process.
A comprehensive simulation of weak-light phase-locking for space-borne gravitational wave antenna
DONG YuHui; LIU HeShan; LUO ZiRen; LI YuQiong; JIN Gang
2016-01-01
A comprehensive simulation was performed to better understand the impacts and effects of the additional technical noises on weak-light phase-locking for LISA.The result showed that the phase of the slave laser tracked well with the received transmitting light under different noise level,and the locking precision was limited by the phase readout noise when the laser frequency noise and clock jitter noise were removed.This result was then confirmed by a benchtop experimental test.The required LISA noise floor was recovered from the simulation which proved the validity of the simulation program.In order to convert the noise function into real time data with random characteristics,an algorism based on Fourier transform was also invented.
Critical points in the Bragg glass phase of a weakly pinned crystal of Ca3Rh4Sn13
S Sarkar; A D Thakur; C V Tomy; G Balakrishnan; D McK Paul; S Ramakrishnan; A K Grover
2006-01-01
New experimental data are presented on the scan rate dependence of the magnetization hysteresis width () (∝ critical current density c()) in isothermal - scans in a weakly pinned single crystal of Ca3Rh4Sn13, which displays second magnetization peak (SMP) anomaly as distinct from the peak effect (PE). We observe an interesting modulation in the field dependence of a parameter which purports to measure the dynamical annealing of the disordered bundles of vortices injected through the sample edges towards the destined equilibrium vortex state at a given . These data, in conjunction with the earlier observations made while studying the thermomagnetic history dependence in c() in the tracing of the minor hysteresis loops, imply that the partially disordered state heals towards the more ordered state between the peak field of the SMP anomaly and the onset field of the PE. The vortex phase diagram in the given crystal of Ca3Rh4Sn13 has been updated in the context of the notion of the phase coexistence of the ordered and disordered regions between the onset field of the SMP anomaly and the spinodal line located just prior to the irreversibility line. A multi-critical point and a critical point in the (, ) region of the Bragg glass phase have been marked in this phase diagram and the observed behavior is discussed in the light of recent data on multi-critical point in the vortex phase diagram in a single crystal of Nb.
Ferwerda, H.A.; Hoenders, B.J.
1975-01-01
In this paper we discuss the reconstruction of a weak phase-amplitude object from its intensity image. This problem occurs in electron microscopy where the weak object approximation holds for not too low accelerating voltages (E>~100 keV). Isoplanatic imaging is assumed. The illumination is supposed
Li, Xibing; Shang, Xueyi; Morales-Esteban, A.; Wang, Zewei
2017-03-01
Seismic P phase arrival picking of weak events is a difficult problem in seismology. The algorithm proposed in this research is based on Empirical Mode Decomposition (EMD) and on the Akaike Information Criterion (AIC) picker. It has been called the EMD-AIC picker. The EMD is a self-adaptive signal decomposition method that not only improves Signal to Noise Ratio (SNR) but also retains P phase arrival information. Then, P phase arrival picking has been determined by applying the AIC picker to the selected main Intrinsic Mode Functions (IMFs). The performance of the EMD-AIC picker has been evaluated on the basis of 1938 micro-seismic signals from the Yongshaba mine (China). The P phases identified by this algorithm have been compared with manual pickings. The evaluation results confirm that the EMD-AIC pickings are highly accurate for the majority of the micro-seismograms. Moreover, the pickings are independent of the kind of noise. Finally, the results obtained by this algorithm have been compared to the wavelet based Discrete Wavelet Transform (DWT)-AIC pickings. This comparison has demonstrated that the EMD-AIC picking method has a better picking accuracy than the DWT-AIC picking method, thus showing this method's reliability and potential.
Schwahn, D
2002-01-01
Binary blends of statistical polybutadiene copolymers of different vinyl content and molar volume were explored by small-angle neutron scattering. These samples represent the most simple class of statistical copolymer mixtures. In spite of this simplicity, changes in vinyl content, molar volume, and deuterium and hydrogen content of the chains give rise to strong effects; phase separation occurs from minus 230 C to more than plus 200 C and can even reverse from an enthalpically driven one at low temperatures to an entropically driven one at high temperatures. The entropic and enthalpic terms of the Flory-Huggins parameter as determined from the experiment are in excellent agreement with lattice cluster theory calculations. (orig.)
Quantification of plaque stiffness by Brillouin microscopy (Conference Presentation)
Antonacci, Giuseppe; Pedrigi, Ryan; Krams, Rob; Török, Peter
2016-03-01
Spontaneous Brillouin scattering is an inelastic scattering process arising from inherent thermal density fluctuations, or acoustic phonons, propagating in a medium. Over the last few years, Brillouin spectroscopy has shown great potential to become a reliable non-invasive diagnostic tool due to its unique capability of retrieving viscoelastic properties of materials such as strain and stiffness. The detection of the weak scattered light, in addition to the resolution of the Brillouin peaks (typically shifted by few GHz from the central peak) represent one of the greatest challenges in Brillouin. The recent development of high sensitivity CCD cameras has brought Brillouin spectroscopy from a point sampling technique to a new imaging modality. Furthermore, the application of Virtually Imaged Phased Array (VIPA) etalons has dramatically reduced insertion loss simultaneously allowing fast (myocardial infarction yet it is not currently possible to credibly assess its stiffness due to lack of suitable methods.
Shu, Chuan-Cun; Henriksen, Niels E.
2012-01-01
We implement phase-only shaped laser pulses within quantum optimal control theory for laser-molecule interaction. This approach is applied to the indirect photofragmentation dynamics of NaI in the weak-field limit. It is shown that optimized phase-modulated pulses with a fixed frequency...
Zhao, Kailou; Yang, Fan; Xia, Hongjun; Wang, Fei; Song, Qingguo; Bai, Quan
2015-03-01
In this study, 3-diethylamino-1-propyne was covalently bonded to the azide-silica by a click reaction to obtain a novel dual-function mixed-mode chromatography stationary phase for protein separation with a ligand containing tertiary amine and two ethyl groups capable of electrostatic and hydrophobic interaction functionalities, which can display hydrophobic interaction chromatography character in a high-salt-concentration mobile phase and weak anion exchange character in a low-salt-concentration mobile phase employed for protein separation. As a result, it can be employed to separate proteins with weak anion exchange and hydrophobic interaction modes, respectively. The resolution and selectivity of the stationary phase were evaluated in both hydrophobic interaction and ion exchange modes with standard proteins, respectively, which can be comparable to that of conventional weak anion exchange and hydrophobic interaction chromatography columns. Therefore, the synthesized weak anion exchange/hydrophobic interaction dual-function mixed-mode chromatography column can be used to replace two corresponding conventional weak anion exchange and hydrophobic interaction chromatography columns to separate proteins. Based on this mixed-mode chromatography stationary phase, a new off-line two-dimensional liquid chromatography technology using only a single dual-function mixed-mode chromatography column was developed. Nine kinds of tested proteins can be separated completely using the developed method within 2.0 h.
... include: Arthritis Fractures Dislocations Bad sprains Tendon and muscle injuries Evaluating Hand Stiffness Your doctor will ask when the stiffness ... scan. CAUSES SIGNS AND ... stretching exercises for the joints and muscles to help loosen them. Different types of splints ...
Gritti, Fabrice; Guiochon, Georges
2009-03-06
The overloaded band profiles of five acido-basic compounds were measured, using weakly buffered mobile phases. Low buffer concentrations were selected to provide a better understanding of the band profiles recorded in LC/MS analyses, which are often carried out at low buffer concentrations. In this work, 10 microL samples of a 50 mM probe solution were injected into C(18)-bonded columns using a series of five buffered mobile phases at (SW)pH between 2 and 12. The retention times and the shapes of the bands were analyzed based on thermodynamic arguments. A new adsorption model that takes into account the simultaneous adsorption of the acidic and the basic species onto the endcapped adsorbent, predicts accurately the complex experimental profiles recorded. The adsorption mechanism of acido-basic compounds onto RPLC phases seems to be consistent with the following microscopic model. No matter whether the acid or the base is the neutral or the basic species, the neutral species adsorbs onto a large number of weak adsorption sites (their saturation capacity is several tens g/L and their equilibrium constant of the order of 0.1 L/g). In contrast, the ionic species adsorbs strongly onto fewer active sites (their saturation capacity is about 1g/L and their equilibrium constant of the order of a few L/g). From a microscopic point of view and in agreement with the adsorption isotherm of the compound measured by frontal analysis (FA) and with the results of Monte-Carlo calculations performed by Schure et al., the first type of adsorption sites are most likely located in between C(18)-bonded chains and the second type of adsorption sites are located deeper in contact with the silica surface. The injected concentration (50 mM) was too low to probe the weakest adsorption sites (saturation capacity of a few hundreds g/L with an equilibrium constant of one hundredth of L/g) that are located at the very interface between the C(18)-bonded layer and the bulk phase.
Ciccoto, Giuseppe; Blaya, Maike; Kelley, Roger E
2013-02-01
Recognizing stiff person syndrome is clinically important. It is uncommon, characterized by body stiffness associated with painful muscle spasms, and varies in location and severity. It is subdivided into stiff trunk versus stiff limb presentation, and as a progressive encephalomyelitis. Stiff person-type syndrome also reflects a paraneoplastic picture. Most patients demonstrate exaggerated lumbar lordosis. Roughly 60% of patients have antiglutamic acid decarboxylase antibodies in the blood and the cerebrospinal fluid. The differential diagnosis includes many severe conditions. There are reports of response to muscle relaxants, immunosuppressants, intravenous gamma globulin, plasma exchange, a number of anticonvulsants, and botulinum toxin.
Shu, Chuan-Cun; Henriksen, Niels E
2012-01-28
We implement phase-only shaped laser pulses within quantum optimal control theory for laser-molecule interaction. This approach is applied to the indirect photofragmentation dynamics of NaI in the weak-field limit. It is shown that optimized phase-modulated pulses with a fixed frequency distribution can substantially modify transient dissociation probabilities as well as the momentum distribution associated with the relative motion of Na and I.
Escher, Joachim; Matioc, Bogdan-Vasile
2011-01-01
We prove global existence of nonnegative weak solutions to a degenerate parabolic system which models the interaction of two thin fluid films in a porous medium. Furthermore, we show that these weak solutions converge at an exponential rate towards flat equilibria.
Estimating Gear Teeth Stiffness
Pedersen, Niels Leergaard
2013-01-01
The estimation of gear stiffness is important for determining the load distribution between the gear teeth when two sets of teeth are in contact. Two factors have a major influence on the stiffness; firstly the boundary condition through the gear rim size included in the stiffness calculation...... and secondly the size of the contact. In the FE calculation the true gear tooth root profile is applied. The meshing stiffness’s of gears are highly non-linear, it is however found that the stiffness of an individual tooth can be expressed in a linear form assuming that the contact length is constant....
Stiffness of compression devices
Giovanni Mosti
2013-03-01
Full Text Available This issue of Veins and Lymphatics collects papers coming from the International Compression Club (ICC Meeting on Stiffness of Compression Devices, which took place in Vienna on May 2012. Several studies have demonstrated that the stiffness of compression products plays a major role for their hemodynamic efficacy. According to the European Committee for Standardization (CEN, stiffness is defined as the pressure increase produced by medical compression hosiery (MCH per 1 cm of increase in leg circumference.1 In other words stiffness could be defined as the ability of the bandage/stockings to oppose the muscle expansion during contraction.
Samatham, S. Shanmukharao; Suresh, K. G.
2017-01-01
The detailed magnetic study of complex 3d-electron based Fe3Ga4 is reported. It undergoes paramagnetic to antiferromagnetic (TN) and antiferromagnetic to ferromagnetic (TC) transitions respectively around 380 and 70 K. The thermal hysteresis of field-cooled cooling (FCC) and field-cooled warming (FCW) hints at first order phase transition below Curie temperature. A weak phase coexistence of ferro and antiferromagnetic phases is suggested by exploring the arrest-like first-order phenomenon. In the intermediate temperature range, field-driven metamagnetic transition from antiferro to ferromagnetic phase is confirmed. Further bringing the system very near to TN, field-induced transitions disappear and above TN predominant paramagnetic contribution is evident. The magnetic H-T phase diagram distinguishing different magnetic phases of Fe3Ga4 is obtained.
Heersche, H.B.; Jarillo-Herrero, P.; Oostinga, J.B.; Vandersypen, L.M.K.; Morpurgoa, A.F.
2007-01-01
The electronic transport properties of graphene exhibit pronounced differences from those of conventional two dimensional electron systems investigated in the past. As a consequence, well established phenomena such as the integer quantum Hall effect and weak localization manifest themselves differen
Gustafson, Jonathan A.; Gorman, Shannon; Fitzgerald, G. Kelley; Farrokhi, Shawn
2017-01-01
Increased walking knee joint stiffness has been reported in patients with knee osteoarthritis (OA) as a compensatory strategy to improve knee joint stability. However, presence of episodic self-reported knee instability in a large subgroup of patients with knee OA may be a sign of inadequate walking knee joint stiffness. The objective of this work was to evaluate the differences in walking knee joint stiffness in patients with knee OA with and without self-reported instability and examine the relationship between walking knee joint stiffness with quadriceps strength, knee joint laxity, and varus knee malalignment. Overground biomechanical data at a self-selected gait velocity was collected for 35 individuals with knee OA without self-reported instability (stable group) and 17 individuals with knee OA and episodic self-reported instability (unstable group). Knee joint stiffness was calculated during the weight-acceptance phase of gait as the change in the external knee joint moment divided by the change in the knee flexion angle. The unstable group walked with lower knee joint stiffness (p=0.01), mainly due to smaller heel-contact knee flexion angles (pknee flexion excursions (pknee stable counterparts. No significant relationships were observed between walking knee joint stiffness and quadriceps strength, knee joint laxity or varus knee malalignment. Reduced walking knee joint stiffness appears to be associated with episodic knee instability and independent of quadriceps muscle weakness, knee joint laxity or varus malalignment. Further investigations of the temporal relationship between self-reported knee joint instability and walking knee joint stiffness are warranted. PMID:26481256
Gustafson, Jonathan A; Gorman, Shannon; Fitzgerald, G Kelley; Farrokhi, Shawn
2016-01-01
Increased walking knee joint stiffness has been reported in patients with knee osteoarthritis (OA) as a compensatory strategy to improve knee joint stability. However, presence of episodic self-reported knee instability in a large subgroup of patients with knee OA may be a sign of inadequate walking knee joint stiffness. The objective of this work was to evaluate the differences in walking knee joint stiffness in patients with knee OA with and without self-reported instability and examine the relationship between walking knee joint stiffness with quadriceps strength, knee joint laxity, and varus knee malalignment. Overground biomechanical data at a self-selected gait velocity was collected for 35 individuals with knee OA without self-reported instability (stable group) and 17 individuals with knee OA and episodic self-reported instability (unstable group). Knee joint stiffness was calculated during the weight-acceptance phase of gait as the change in the external knee joint moment divided by the change in the knee flexion angle. The unstable group walked with lower knee joint stiffness (p=0.01), mainly due to smaller heel-contact knee flexion angles (pknee flexion excursions (pknee stable counterparts. No significant relationships were observed between walking knee joint stiffness and quadriceps strength, knee joint laxity or varus knee malalignment. Reduced walking knee joint stiffness appears to be associated with episodic knee instability and independent of quadriceps muscle weakness, knee joint laxity or varus malalignment. Further investigations of the temporal relationship between self-reported knee joint instability and walking knee joint stiffness are warranted.
Multiple anesthetics for a patient with stiff-person syndrome.
Cassavaugh, Jessica M; Oravitz, Todd M
2016-06-01
Stiff-person syndrome is a progressive disease of muscle rigidity and spasticity due to a deficiency in the production of γ-aminobutyric acid. Because of the rarity of the condition, little is known about effects of anesthesia on patients with stiff-person syndrome. This report describes the clinical course for a single patient with stiff-person syndrome who received general anesthesia on 3 separate occasions. Her anesthetics included use of both neuromuscular blockade and volatile agents. Unlike several previous reports regarding anesthesia and stiff-person syndrome, the postoperative period for this patient did not require prolonged intubation or result in any residual weakness.
Gritti, Fabrice [University of Tennessee, Knoxville (UTK); Guiochon, Georges A [ORNL
2009-01-01
excellent agreement was achieved between experimental profiles and those calculated with a two-sites adsorption isotherm model at all {sub W}{sup S}pHs. The neutral species adsorbs strongly on a first type of sites that have a high density while the ionic species adsorb preferentially on a second type of sites that have a very low density. The evolution of the peak shape when the {sub W}{sup S}pH changes from acidic to basic is well explained by the weak buffer capacity of the mobile phase used compared to the concentration of the eluted compounds.
Paduani, C. [DF-UFSC, Florianopolis, CEP, SC (Brazil); Schaf, J. [IF-UFRGS, Porto Alegre, CEP, RS (Brazil); Persiano, A.I.C. [DF-ICEX-UFMG, Belo Horizonte, CEP, MG (Brazil); Raposo, M.T. [DCNAT-UFSJ, Sao Joao Del Rei, CEP, MG (Brazil); Ardisson, J.D. [CDTN, Belo Horizonte, CEP, MG (Brazil); Takeuchi, A.Y. [DF-UFES, Vitoria, CEP, ES (Brazil)
2009-06-15
In this work we report the observation of weak ferromagnetism in the hexagonal C14 Laves phase (s.g. P63/mmc) of the (Fe{sub 1-x}Ni{sub x}){sub 2}Nb system, which has been reported as nonmagnetic in the literature. A larger unit cell volume is observed as compared to Fe{sub 2}Nb. From low-temperature magnetization measurements it is found that the Ni substitution for Fe indeed leads to the onset of a weak ferromagnetic ordering in the C14 Laves phase of this pseudobinary system. (copyright 2009 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)
Effect of site disorder on the magnetic properties of weak itinerant ferromagnet Ni75Al25
Anita Semwal; S N Kaul
2003-03-01
Detailed study of Ni75Al25 samples with varying degree of site disorder reveals that site disorder promotes magnetic excitations such as spin waves and local spin-density ﬂuctuations and thereby reduces both spin-wave stiffness and Curie temperature. Irreversibility lines in the - phase diagram of the weak itinerant ferromagnet Ni75Al25 have been determined for the ﬁrst time and the effect of site disorder on them has been ascertained.
Nonomura, Yoshihiko; Tomita, Yusuke
2015-12-01
Recently we showed that the critical nonequilibrium relaxation in the Swendsen-Wang algorithm is widely described by the stretched-exponential relaxation of physical quantities in the Ising or Heisenberg models. Here we make a similar analysis in the Berezinsky-Kosterlitz-Thouless phase transition in the two-dimensional (2D) X Y model and in the first-order phase transition in the 2D q =5 Potts model and find that these phase transitions are described by the simple exponential relaxation and power-law relaxation of physical quantities, respectively. We compare the relaxation behaviors of these phase transitions with those of the second-order phase transition in the three- and four-dimensional X Y models and in the 2D q -state Potts models for 2 ≤q ≤4 and show that the species of phase transitions can be clearly characterized by the present analysis. We also compare the size dependence of relaxation behaviors of the first-order phase transition in the 2D q =5 and 6 Potts models and propose a quantitative criterion on "weakness" of the first-order phase transition.
Nanocharacterization of the negative stiffness of ferroelectric materials
Alipour Skandani, A.; Ctvrtlik, R.; Al-Haik, M.
2014-08-01
Phase changing materials such as ferroelectric materials could exhibit negative stiffness under certain thermomechanical environments. This negative stiffness is embodied by a deflection along the opposite direction of the applied load. So far negative stiffness materials were investigated with the specific morphology of embedded inclusions in stiff matrices then the resulting composite is studied to measure the behavior of each constituent indirectly. In this study, a modified nonisothermal nanoindentation method is developed to measure the negative stiffness of triglycine sulfate single crystal directly. This in-situ method is intended to first demonstrate the feasibility of detecting the negative stiffness via nanoindentation and nanocreep of a ferroelectric material at its Curie point and then to quantify the negative stiffness without the need for embedding the crystal within a stiffer matrix.
Ravi Mittal
2017-01-01
Full Text Available Posttraumatic stiff elbow is a frequent and disabling complication and poses serious challenges for its management. In this review forty studies were included to know about the magnitude of the problem, causes, pathology, prevention, and treatment of posttraumatic stiff elbow. These studies show that simple measures such as internal fixation, immobilization in extension, and early motion of elbow joint are the most important steps that can prevent elbow stiffness. It also supports conservative treatment in selected cases. There are no clear guidelines about the choice between the numerous procedures described in literature. However, this review article disproves two major beliefs-heterotopic ossification is a bad prognostic feature, and passive mobilization of elbow causes elbow stiffness.
Mittal, Ravi
2017-01-01
Posttraumatic stiff elbow is a frequent and disabling complication and poses serious challenges for its management. In this review forty studies were included to know about the magnitude of the problem, causes, pathology, prevention, and treatment of posttraumatic stiff elbow. These studies show that simple measures such as internal fixation, immobilization in extension, and early motion of elbow joint are the most important steps that can prevent elbow stiffness. It also supports conservative treatment in selected cases. There are no clear guidelines about the choice between the numerous procedures described in literature. However, this review article disproves two major beliefs-heterotopic ossification is a bad prognostic feature, and passive mobilization of elbow causes elbow stiffness.
Weak Convergence and Weak Convergence
Narita Keiko
2015-09-01
Full Text Available In this article, we deal with weak convergence on sequences in real normed spaces, and weak* convergence on sequences in dual spaces of real normed spaces. In the first section, we proved some topological properties of dual spaces of real normed spaces. We used these theorems for proofs of Section 3. In Section 2, we defined weak convergence and weak* convergence, and proved some properties. By RNS_Real Mizar functor, real normed spaces as real number spaces already defined in the article [18], we regarded sequences of real numbers as sequences of RNS_Real. So we proved the last theorem in this section using the theorem (8 from [25]. In Section 3, we defined weak sequential compactness of real normed spaces. We showed some lemmas for the proof and proved the theorem of weak sequential compactness of reflexive real Banach spaces. We referred to [36], [23], [24] and [3] in the formalization.
Shi, Y L; Wu, J X; Zhu, C J; Xu, J P; Yang, Y P
2015-01-01
We examine a Kerr phase gate in a semiconductor quantum well structure based on the tunnelling interference effect. We show that there exist a specific signal field detuning, at which the absorption/amplification of the probe field will be eliminated with the increase of the tunnelling interference. Simultaneously, the probe field will acquire a -\\pi phase shift at the exit of the medium. We demonstrate with numerical simulations that a complete 180^\\circ phase rotation for the probe field at the exit of the medium is achieved, which may result in many applications in information science and telecommunication.
Vigild, Martin Etchells; Eskimergen, Rüya; Mortensen, Kell
2004-01-01
Asymmetrically composed diblock copolymers exhibit multiphase behaviour and transit the lamellae, gyroid and hexagonal cylindrical phases before reaching the order–disorder temperature, TODT. During a heating experiment towards TODT we observe that birefringence measurements are more sensitive th...
Leg stiffness primarily depends on ankle stiffness during human hopping.
Farley, C T; Morgenroth, D C
1999-03-01
When humans hop in place or run forward, they adjust leg stiffness to accommodate changes in stride frequency or surface stiffness. The goal of the present study was to determine the mechanisms by which humans adjust leg stiffness during hopping in place. Five subjects hopped in place at 2.2 Hz while we collected force platform and kinematic data. Each subject completed trials in which they hopped to whatever height they chose ("preferred height hopping") and trials in which they hopped as high as possible ("maximum height hopping"). Leg stiffness was approximately twice as great for maximum height hopping as for preferred height hopping. Ankle torsional stiffness was 1.9-times greater while knee torsional stiffness was 1.7-times greater in maximum height hopping than in preferred height hopping. We used a computer simulation to examine the sensitivity of leg stiffness to the observed changes in ankle and knee stiffness. Our model consisted of four segments (foot, shank, thigh, head-arms-trunk) interconnected by three torsional springs (ankle, knee, hip). In the model, increasing ankle stiffness by 1.9-fold, as observed in the subjects, caused leg stiffness to increase by 2.0-fold. Increasing knee stiffness by 1.7-fold had virtually no effect on leg stiffness. Thus, we conclude that the primary mechanism for leg stiffness adjustment is the adjustment of ankle stiffness.
Behera, Prafulla
2017-01-01
The decay $\\textrm{B}_{\\textrm{s}}^{0} \\to \\textrm{J}/\\psi \\phi(1020) \\to \\mu^{+}\\mu^{-}K^{+}K^{-}$ is used to measure the CP-violating weak phase $\\phi_{\\textrm{s}}$ and the decay width difference $\\Delta \\Gamma_{\\textrm{s}}$ of the B$_{\\textrm{s}}^{0}$\\ light and heavy mass eigenstates with the CMS detector at the LHC. The analysis is performed using an integrated luminosity of 19.7 fb$^{-1}$ collected in pp collisions at a centre-of-mass energy of 8 TeV corresponds to a total of 49 200 reconstructed B$_{s}^{0}$ decays. A time-dependent and flavour-tagged angular analysis is performed. The weak phase is measured to be $\\phi_{\\textrm{s}} = - 0.075 \\pm 0.097 (\\textrm{stat.}) \\pm 0.031 (\\textrm{syst.})$ rad, and the decay width difference is $\\Delta \\Gamma_{s} = 0.095 \\pm 0.013 (\\textrm{stat.}) \\pm 0.007 (\\textrm{syst.}) ~\\textrm{ps}^{-1}$
Without the weak force, the sun wouldn't shine. The weak force causes beta decay, a form of radioactivity that triggers nuclear fusion in the heart of the sun. The weak force is unlike other forces: it is characterised by disintegration. In beta decay, a down quark transforms into an up quark and an electron is emitted. Some materials are more radioactive than others because the delicate balance between the strong force and the weak force varies depending on the number of particles in the atomic nucleus. We live in the midst of a natural radioactive background that varies from region to region. For example, in Cornwall where there is a lot of granite, levels of background radiation are much higher than in the Geneva region. Text for the interactive: Move the Geiger counter to find out which samples are radioactive - you may be surprised. It is the weak force that is responsible for the Beta radioactivity here. The electrons emitted do not cross the plastic cover. Why do you think there is some detected radioa...
Dynamic stiffness of suction caissons
Ibsen, Lars Bo; Liingaard, Morten; Andersen, Lars
The purpose of this report is to evaluate the dynamic soil-structure interaction of suction caissons for offshore wind turbines. The investigation is limited to a determination of the vertical dynamic stiffness of suction caissons. The soil surrounding the foundation is homogenous with linear...... of the skirt length, Poisson's ratio and the ratio between soil stiffness and skirt stiffness. Finally the dynamic behaviour at high frequencies is investigated....... viscoelastic properties. The dynamic stiffness of the suction caisson is expressed by dimensionless frequency-dependent dynamic stiffness coefficients corresponding to the vertical degree of freedom. The dynamic stiffness coefficients for the foundations are evaluated by means of a dynamic three...
Kleinert, H
2007-01-01
At ultralow temperatures, polymers exhibit quantum behavior, which is calculated here for the second and fourth moments of the end-to-end distribution in the large-stiffness regime. The result should be measurable for polymers in wide optical traps.
Lämmerhofer, Michael; Nogueira, Raquel; Lindner, Wolfgang
2011-06-01
We recently introduced a mixed-mode reversed-phase/weak anion-exchange type separation material based on silica particles which consisted of a hydrophobic alkyl strand with polar embedded groups (thioether and amide functionalities) and a terminal weak anion-exchange-type quinuclidine moiety. This stationary phase was designed to separate molecules by lipophilicity and charge differences and was mainly devised for peptide separations with hydroorganic reversed-phase type elution conditions. Herein, we demonstrate the extraordinary flexibility of this RP/WAX phase, in particular for peptide separations, by illustrating its applicability in various chromatographic modes. The column packed with this material can, depending on the solute character and employed elution conditions, exploit attractive or repulsive electrostatic interactions, and/or hydrophobic or hydrophilic interactions as retention and selectivity increments. As a consequence, the column can be operated in a reversed-phase mode (neutral compounds), anion-exchange mode (acidic compounds), ion-exclusion chromatography mode (cationic solutes), hydrophilic interaction chromatography mode (polar compounds), and hydrophobic interaction chromatography mode (e.g., hydrophobic peptides). Mixed-modes of these chromatographic retention principles may be materialized as well. This allows an exceptionally flexible adjustment of retention and selectivity by tuning experimental conditions. The distinct separation mechanisms will be outlined by selected examples of peptide separations in the different modes.
Fahr, A.; Braun, W.; Kurylo, M. J.
1993-01-01
Ultraviolet absorption cross sections of CH3CFCl2(HCFC-141b) were determined in the gas phase (190-260 nm) and liquid phase (230-260 mm) at 298 K. The liquid phase absorption cross sections were then converted into accurate gas phase values using a previously described procedure. It has been demonstrated that scattered light from the shorter-wavelength region (as little as several parts per thousand) can seriously compromise the absorption cross-section measurement, particularly at longer wavelengths where cross sections are low, and can be a source of discrepancies in the cross sections of weakly absorbing halocarbons reported in the literature. A modeling procedure was developed to assess the effect of scattered light on the measured absorption cross section in our experiments, thereby permitting appropriate corrections to be made on the experimental values. Modeled and experimental results were found to be in good agreement. Experimental results from this study were compared with other available determinations and provide accurate input for calculating the atmospheric lifetime of HCFC-141b.
Measuring the weak phase in the decay $B_s^0\\rightarrow \\phi\\phi$ at the LHCb experiment
Styles, N; Cowan, G; Muheim, F; Xie, Y
2010-01-01
The vector-vector penguin decay $B_s^0\\rightarrow \\phi\\phi$ provides a potential probe into new CP-violating physics beyond the standard model. Studies using the full angular decay information are presented to determine the sensitivity to the CP-violating phase $\\Phi$ and the linear polarisation fractions. This work uses DC06 Monte Carlo data. A sensitivity of $\\sigma$ ($\\Phi$) = 0.08 rad is expected with 10 fb$^{-1}$ of LHCb data. However, recent CDF measurements suggest a branching ratio of (2.4$\\pm$0.8) x 10$^{-1}$, and based on this central value, the sensitivity is expected to improve to $\\sigma(\\Phi)$ = 0.06 rad with 10 fb$^{-1}$. This sensitivity assumes an estimated yield of 4.6k signal events in 2 fb$^{-1}$, a B/S ratio of < 2.4 (at a 95% confidence level), and a tagging power of 6.8%.
Depression, Anxiety, and Arterial Stiffness
Seldenrijk, Adrie; van Hout, Hein P. J.; van Marwijk, Harm W. J.; de Groot, Eric; Gort, Johan; Rustemeijer, Cees; Diamant, Michaela; Penninx, Brenda W. J. H.
2011-01-01
Background: Arterial stiffness gains attention as a potential mechanism underlying the frequently found association between depression or anxiety and cardiovascular disease. However, observations regarding stiffness and psychopathology were often based on small samples. The current study aimed to
Genetics of Stiff Child Syndrome
J Gordon Millichap
2005-11-01
Full Text Available A Chinese boy with a DYT1 gene mutation presented with muscle stiffness, painful muscle spasms, myoclonus, and dystonia, compatible with stiff child syndrome, and is reported from Queen Mary Hospital, the University of Hong Kong.
Mazur, O. Yu.; Stefanovich, L. I.; Yurchenko, V. M.
2016-08-01
The kinetics of the formation and growth of 180° domains in a weak quasi-stationary external electric field has been considered in the framework of the phenomenological Ginzburg-Landau model using the example of sodium nitrite (NaNO2) crystals that undergo a first-order ferroelectric phase transition of the order-disorder type. The influence of the rate and temperature of quenching, as well as the strength of an external electric field, on the subsequent evolution of the system toward the thermodynamic equilibrium state has been analyzed. It has been shown that, by varying a weak external electric field applied to the ferroelectric crystal after quenching, it is possible to obtain both single-domain and multi-domain ordered structures. It has been established that the formation of nonequilibrium ("virtual") multi-domain structures of the asymmetric type is possible for particular strengths of the electric field applied to the ferroelectric after quenching. A similar effect can be achieved by varying the depth of quenching of the sample. It has been found that, if the size of the order parameter inhomogeneities formed at the stage of quenching does not exceed a critical value, they can be reoriented partially or completely into domains of opposite sign. For this purpose, the relaxation after quenching should be performed in an external electric field of the appropriate sign.
Fu, Houqiang; Lu, Zhijian; Zhao, Yuji [School of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, AZ 85287 (United States)
2016-06-15
We study the low efficiency droop characteristics of semipolar InGaN light-emitting diodes (LEDs) using modified rate equation incoporating the phase-space filling (PSF) effect where the results on c-plane LEDs are also obtained and compared. Internal quantum efficiency (IQE) of LEDs was simulated using a modified ABC model with different PSF filling (n{sub 0}), Shockley-Read-Hall (A), radiative (B), Auger (C) coefficients and different active layer thickness (d), where the PSF effect showed a strong impact on the simulated LED efficiency results. A weaker PSF effect was found for low-droop semipolar LEDs possibly due to small quantum confined Stark effect, short carrier lifetime, and small average carrier density. A very good agreement between experimental data and the theoretical modeling was obtained for low-droop semipolar LEDs with weak PSF effect. These results suggest the low droop performance may be explained by different mechanisms for semipolar LEDs.
Evidence of weak ferromagnetism in the C14 Laves phase (Fe{sub 1-x}Co{sub x}){sub 2}Nb system
Paduani, C. [DF-UFSC, Florianopolis, CEP 88040-900, SC (Brazil)], E-mail: paduani@fisica.ufsc.br; Schaf, J. [IF-UFRGS, Porto Alegre, CEP 91501-970, RS (Brazil); Persiano, A.I.C. [DF-ICEX-UFMG, Belo Horizonte, CP 702, 30161-970 MG (Brazil); Ardisson, J.D. [CDTN, Belo Horizonte, CEP 30123-970, MG (Brazil); Takeuchi, A.Y. [DF-UFES, Vitoria, CEP 29075-910, ES (Brazil); Raposo, M.T. [DCNAT-UFSJ, Sao Joao Del Rei, CEP 36300-000, MG (Brazil)
2009-04-17
In this work are studied the structure and magnetic properties of the (Fe{sub 1-x}Co{sub x}){sub 2}Nb alloys with X-ray diffraction and magnetization measurements. The results confirm the formation of the C14 Laves phase in the Co concentration range 0{<=}x{<=}0.55. The unit cell volume decreases with the increase of the cobalt concentration and is larger than in Fe{sub 2}Nb. Magnetization measurements indicate that this system is weakly ferromagnetic at low temperatures for x{<=}0.55. From the behavior of the M(T) curves a cluster-glass-like mechanism is predicted for this system below 50 K.
Faridzadeh, Monire; Gholami, Asghar; Ghassemlooy, Zabih; Rajbhandari, Sujan
2012-08-01
In this paper a hybrid modulation scheme based on pulse position modulation (PPM) and binary phase shift keying subcarrier intensity modulation (BPSK-SIM) schemes for free-space optical communications is proposed. The analytical bit error rate (BER) performance is investigated in weak and saturated turbulence channels and results are verified with the simulation data. Results show that performance of PPM-BPSK-SIM is superior to BPSK-SIM in all turbulence regimes; however, it outperforms 2-PPM for the turbulence variance σ(1)(2)>0.2. PPM-BPSK-SIM offers a signal-to-noise ratio (SNR) gain of 50 dB in the saturation regime compared to BPSK at a BER of 10(-6). The SNR gain in comparison to PPM improves as the strength of the turbulence level increases.
Yang, Fan; Bai, Quan; Zhao, Kailou; Gao, Dong; Tian, Lei
2015-02-01
A novel dual-function mixed-mode stationary phase based on poly(glycidyl methacrylate-co-ethylene dimethacrylate) microspheres was synthesized by thiol-ene click chemistry and characterized by infrared spectroscopy and elemental analysis. The new system displays both hydrophobic interaction chromatography (HIC) character in a high salt concentration mobile phase, and weak cation exchange (WCX) chromatography character in a low salt concentration mobile phase. It can be used to separate proteins in both ion-exchange chromatography (IEC) mode and HIC mode. The resolution and selectivity of the stationary phase were evaluated in both HIC mode and IEC mode using protein standards. In comparison with the conventional WCX and HIC columns, the results were satisfactory and acceptable. Protein mass and bioactivity recoveries of more than 96% can be achieved in both HIC mode and IEC mode using this column. The results indicate that the novel dual-function mixed-mode column in many cases can replace the use of two individual WCX and HIC columns. In addition, the effects on protein separation of different ligand structures in the dual-function stationary phase and the pH of the mobile phase used were also investigated in detail. The results show that electrostatic interaction of the ligand with proteins must match the hydrophobicity of the ligand, which is an important factor to prepare the dual-function stationary phase. On the basis of this dual-function mixed-mode chromatography column, a new two-dimensional liquid chromatography technology with a single column system was also developed in this study, and was used to renature and purify recombinant human interferon-γ from inclusion bodies. The mass recovery, purity, and specific bioactivity obtained for the purified recombinant human interferon-γ were 87.2%, 92.4%, and 2.8 × 10(7) IU/mg, respectively, in IEC mode, and 83.4%, 95.2%, and 4.3 × 10(7) IU/mg, respectively, in HIC mode. The results indicate that the
On gear tooth stiffness evaluation
Pedersen, Niels Leergaard; Jørgensen, Martin Felix
2014-01-01
The estimation of gear stiffness is important for determining the load distribution between the gear teeth when two sets of teeth are in contact. Two factors have a major influence on the stiffness; firstly the boundary condition through the gear rim size included in the stiffness calculation...... and secondly the size of the contact. In the FE calculation the true gear tooth root profile is applied. The meshing stiffnesses of gears are highly non-linear, it is however found that the stiffness of an individual tooth can be expressed in a linear form assuming that the contact width is constant. © 2014...
Selleri, Franco
2015-01-01
Weak Relativity is an equivalent theory to Special Relativity according to Reichenbach’s definition, where the parameter epsilon equals to 0. It formulates a Neo-Lorentzian approach by replacing the Lorentz transformations with a new set named “Inertial Transformations”, thus explaining the Sagnac effect, the twin paradox and the trip from the future to the past in an easy and elegant way. The cosmic microwave background is suggested as a possible privileged reference system. Most importantly, being a theory based on experimental proofs, rather than mutual consensus, it offers a physical description of reality independent of the human observation.
Stiffness, resilience, compressibility
Leu, Bogdan M. [Argonne National Laboratory, Advanced Photon Source (United States); Sage, J. Timothy, E-mail: jtsage@neu.edu [Northeastern University, Department of Physics and Center for Interdisciplinary Research on Complex Systems (United States)
2016-12-15
The flexibility of a protein is an important component of its functionality. We use nuclear resonance vibrational spectroscopy (NRVS) to quantify the flexibility of the heme iron environment in the electron-carrying protein cytochrome c by measuring the stiffness and the resilience. These quantities are sensitive to structural differences between the active sites of different proteins, as illustrated by a comparative analysis with myoglobin. The elasticity of the entire protein, on the other hand, can be probed quantitatively from NRVS and high energy-resolution inelastic X-ray scattering (IXS) measurements, an approach that we used to extract the bulk modulus of cytochrome c.
Adaptive gravity and joint stiffness compensation methods for force-controlled arm supports
Lobo Prat, J.; Keemink, Arvid Quintijn Leon; Koopman, Hubertus F.J.M.; Stienen, Arno; Veltink, Petrus H.; Braun, D.; Yu, H.; Campolo, D.
2015-01-01
People with muscular weakness can benefit from arm supports that compensate the weight of their arms. Due to the disuse of the arms, passive joint stiffness increases and providing only gravity compensation becomes insufficient to support the arm function. Hence, joint stiffness compensation is also
Pharmacological modulation of arterial stiffness.
Boutouyrie, Pierre
2011-09-10
Arterial stiffness has emerged as an important marker of cardiovascular risk in various populations and reflects the cumulative effect of cardiovascular risk factors on large arteries, which in turn is modulated by genetic background. Arterial stiffness is determined by the composition of the arterial wall and the arrangement of these components, and can be studied in humans non-invasively. Age and distending pressure are two major factors influencing large artery stiffness. Change in arterial stiffness with drugs is an important endpoint in clinical trials, although evidence for arterial stiffness as a therapeutic target still needs to be confirmed. Drugs that independently affect arterial stiffness include antihypertensive drugs, mostly blockers of the renin-angiotensin-aldosterone system, hormone replacement therapy and some antidiabetic drugs such as glitazones. While the quest continues for \\'de-stiffening drugs\\
Stiff directed lines in random media.
Boltz, Horst-Holger; Kierfeld, Jan
2013-07-01
We investigate the localization of stiff directed lines with bending energy by a short-range random potential. We apply perturbative arguments, Flory scaling arguments, a variational replica calculation, and functional renormalization to show that a stiff directed line in 1+d dimensions undergoes a localization transition with increasing disorder for d>2/3. We demonstrate that this transition is accessible by numerical transfer matrix calculations in 1+1 dimensions and analyze the properties of the disorder-dominated phase in detail. On the basis of the two-replica problem, we propose a relation between the localization of stiff directed lines in 1+d dimensions and of directed lines under tension in 1+3d dimensions, which is strongly supported by identical free-energy distributions. This shows that pair interactions in the replicated Hamiltonian determine the nature of directed line localization transitions with consequences for the critical behavior of the Kardar-Parisi-Zhang equation. We support the proposed relation to directed lines via multifractal analysis, revealing an analogous Anderson transition-like scenario and a matching correlation length exponent. Furthermore, we quantify how the persistence length of the stiff directed line is reduced by disorder.
Stiffness instability in short-range critical wetting
Jin, Albert J.; Fisher, Michael E.
1993-07-01
Recent theoretical work has shown that an interface separating two fluid phases suffers changes in its (bare) effective stiffness, Σ~(l)=Σ~∞+ΔΣ~(l), when located at a distance l from a planar wall: terms varying as lke-jκl appear in ΔΣ~ (where 0wetting the wall). This may induce first-order wetting transitions when critical wetting had been expected. This general behavior of ΔΣ~(l) is confirmed using an integral/adsorption constraint to determine l, in place of the original crossing constraint. The exact linearized functional renormalization-group technique is used to analyze the full wetting-phase diagram as a function of T, of ω=kBTcWκ2/4πΣ~(TcW), and of q, the amplitude of the -le-2κl term in ΔΣ~. For dimensions d>3, any positive q (as generally expected) yields first-order wetting. The same is true for d=3 provided ω1/2 nonclassical critical behavior is still found for small q0. Detailed expressions are obtained for , ξ∥, etc., in the various critical and first-order regions. Numerical estimates show that previous Ising-model simulations probably encountered weakly first-order wetting transitions which might explain discrepancies with earlier renormalization-group predictions.
Al Kaissi, Ali; Ryabykh, Sergey; Ochirova, Polina; Kenis, Vladimir; Hofstätter, Jochen G.; Grill, Franz; Ganger, Rudolf; Kircher, Susanne Gerit
2017-01-01
Marked ligamentous hyperlaxity and muscle weakness/wasting associated with awkward gait are the main deficits confused with the diagnosis of myopathy. Seven children (6 boys and 1 girl with an average age of 8 years) were referred to our department because of diverse forms of skeletal abnormalities. No definitive diagnosis was made, and all underwent a series of sophisticated investigations in other institutes in favor of myopathy. We applied our methodology through the clinical and radiographic phenotypes followed by targeted genotypic confirmation. Three children (2 boys and 1 girl) were compatible with the diagnosis of progressive pseudorheumatoid chondrodysplasia. The genetic mutation was correlated with the WISP 3 gene actively expressed by articular chondrocytes and located on chromosome 6. Klinefelter syndrome was the diagnosis in 2 boys. Karyotyping confirmed 47,XXY (aneuploidy of Klinefelter syndrome). And 2 boys were finally diagnosed with Morquio syndrome (MPS type IV A) as both showed missense mutations in the N-acetylgalactosamine-sulfate sulfatase gene. Misdiagnosis can lead to the initiation of a long list of sophisticated investigations. PMID:28210640
Sean P Parsons
2016-02-01
Full Text Available Pacemaker activities generated by networks of interstitial cells of Cajal (ICC, in conjunction with the enteric nervous system, orchestrate most motor patterns in the gastrointestinal tract. It was our objective to understand the role of network features of ICC associated with the myenteric plexus (ICC-MP in the shaping of motor patterns of the small intestine. To that end, a model of weakly coupled oscillators (oscillators influence each other's phase but not amplitude was created with most parameters derived from experimental data. The ICC network is a uniform two dimensional network coupled by gap junctions. All ICC generate pacemaker (slow wave activity with a frequency gradient in mice from 50/min at the proximal end of the intestine to 40/min at the distal end. Key features of motor patterns, directly related to the underlying pacemaker activity, are frequency steps and dislocations. These were accurately mimicked by reduction of coupling strength at a point in the chain of oscillators. When coupling strength was expressed as a product of gap junction density and conductance, and gap junction density was varied randomly along the chain (i.e. spatial noise with a long-tailed distribution, plateau steps occurred at points of low density. As gap junction conductance was decreased, the number of plateaus increased, mimicking the effect of the gap junction inhibitor carbenoxolone. When spatial noise was added to the natural interval gradient, as gap junction conductance decreased, the number of plateaus increased as before but in addition the phase waves frequently changed direction of apparent propagation, again mimicking the effect of carbenoxolone. In summary, key features of the motor patterns that are governed by pacemaker activity may be a direct consequence of biological noise, specifically spatial noise in gap junction coupling and pacemaker frequency.
Parsons, Sean P.; Huizinga, Jan D.
2016-01-01
Pacemaker activities generated by networks of interstitial cells of Cajal (ICC), in conjunction with the enteric nervous system, orchestrate most motor patterns in the gastrointestinal tract. It was our objective to understand the role of network features of ICC associated with the myenteric plexus (ICC-MP) in the shaping of motor patterns of the small intestine. To that end, a model of weakly coupled oscillators (oscillators influence each other's phase but not amplitude) was created with most parameters derived from experimental data. The ICC network is a uniform two dimensional network coupled by gap junctions. All ICC generate pacemaker (slow wave) activity with a frequency gradient in mice from 50/min at the proximal end of the intestine to 40/min at the distal end. Key features of motor patterns, directly related to the underlying pacemaker activity, are frequency steps and dislocations. These were accurately mimicked by reduction of coupling strength at a point in the chain of oscillators. When coupling strength was expressed as a product of gap junction density and conductance, and gap junction density was varied randomly along the chain (i.e., spatial noise) with a long-tailed distribution, plateau steps occurred at pointsof low density. As gap junction conductance was decreased, the number of plateaus increased, mimicking the effect of the gap junction inhibitor carbenoxolone. When spatial noise was added to the natural interval gradient, as gap junction conductance decreased, the number of plateaus increased as before but in addition the phase waves frequently changed direction of apparent propagation, again mimicking the effect of carbenoxolone. In summary, key features of the motor patterns that are governed by pacemaker activity may be a direct consequence of biological noise, specifically spatial noise in gap junction coupling and pacemaker frequency. PMID:26869875
Parsons, Sean P; Huizinga, Jan D
2016-01-01
Pacemaker activities generated by networks of interstitial cells of Cajal (ICC), in conjunction with the enteric nervous system, orchestrate most motor patterns in the gastrointestinal tract. It was our objective to understand the role of network features of ICC associated with the myenteric plexus (ICC-MP) in the shaping of motor patterns of the small intestine. To that end, a model of weakly coupled oscillators (oscillators influence each other's phase but not amplitude) was created with most parameters derived from experimental data. The ICC network is a uniform two dimensional network coupled by gap junctions. All ICC generate pacemaker (slow wave) activity with a frequency gradient in mice from 50/min at the proximal end of the intestine to 40/min at the distal end. Key features of motor patterns, directly related to the underlying pacemaker activity, are frequency steps and dislocations. These were accurately mimicked by reduction of coupling strength at a point in the chain of oscillators. When coupling strength was expressed as a product of gap junction density and conductance, and gap junction density was varied randomly along the chain (i.e., spatial noise) with a long-tailed distribution, plateau steps occurred at pointsof low density. As gap junction conductance was decreased, the number of plateaus increased, mimicking the effect of the gap junction inhibitor carbenoxolone. When spatial noise was added to the natural interval gradient, as gap junction conductance decreased, the number of plateaus increased as before but in addition the phase waves frequently changed direction of apparent propagation, again mimicking the effect of carbenoxolone. In summary, key features of the motor patterns that are governed by pacemaker activity may be a direct consequence of biological noise, specifically spatial noise in gap junction coupling and pacemaker frequency.
Koren, S A; Persinger, M A
2002-12-01
In 2002 Persinger, Roll, Tiller, Koren, and Cook considered whether there are physical processes by which recondite information exists within the space and time of objects or events. The stimuli that compose this information might be directly detected within the whole brain without being processed by the typical sensory modalities. We tested the artist Ingo Swann who can reliably draw and describe randomly selected photographs sealed in envelopes in another room. In the present experiment the photographs were immersed continuously in repeated presentations (5 times per sec.) of one of two types of computer-generated complex magnetic field patterns whose intensities were less than 20 nT over most of the area. WINDOWS-generated but not DOS-generated patterns were associated with a marked decrease in Mr. Swann's accuracy. Whereas the DOS software generated exactly the same pattern, WINDOWS software phase-modulated the actual wave form resulting in an infinite bandwidth and complexity. We suggest that information obtained by processes attributed to "paranormal" phenomena have physical correlates that can be masked by weak, infinitely variable magnetic fields.
Axial Dynamic Stiffness of Tubular Piles in Viscoelastic Soil
Bayat, Mehdi; Andersen, Lars Vabbersgaard; Ibsen, Lars Bo
2016-01-01
-resonance are presented .in series of Bessel's function. Important responses, such as dynamic stiffness and phase angle, are compared for different values of the loss factor as the material damping, Y0W1g's modulus and Poisson's ratio in a viscoelastic soil. Results are verified. with known results reported......, whilst the phase angle is independent of the properties of the soil. It is shown that the non-dimensional dynamic stiffness changes linearly with high-frequency load. The conclusion from the results of this study is that the material properties of soil are significant parameters in the dynamic stiffness...... when the dynamic vertical excitation is applied. The smooth surface along the entire interface is considered. The Betti reciprocal theorem along with Somigliana's identity and Green's function are employed to drive the dynamic stiffness of jacket structures. Modes of the resonance and anti...
Petty, Richard E.; And Others
1987-01-01
Addresses the major errors and misconceptions perpetuated by Stiff and Boster's response to criticism of Stiff's 1986 article. Focuses on the major conceptual and methodological issues of Stiff's model. (NKA)
Stiffness of desiccating insect wings
Mengesha, T E; Vallance, R R [Department of Mechanical Engineering, The George Washington University, 738 Phillips Hall, 801 22nd St NW, Washington, DC 20052 (United States); Mittal, R, E-mail: vallance@gwu.edu [Department of Mechanical Engineering, Johns Hopkins University, 126 Latrobe Hall, 3400 N Charles Street, Baltimore, MD 21218 (United States)
2011-03-15
The stiffness of insect wings is typically determined through experimental measurements. Such experiments are performed on wings removed from insects. However, the wings are subject to desiccation which typically leads to an increase in their stiffness. Although this effect of desiccation is well known, a comprehensive study of the rate of change in stiffness of desiccating insect wings would be a significant aid in planning experiments as well as interpreting data from such experiments. This communication presents a comprehensive experimental analysis of the change in mass and stiffness of gradually desiccating forewings of Painted Lady butterflies (Vanessa cardui). Mass and stiffness of the forewings of five butterflies were simultaneously measured every 10 min over a 24 h period. The averaged results show that wing mass declined exponentially by 21.1% over this time period with a time constant of 9.8 h, while wing stiffness increased linearly by 46.2% at a rate of 23.4 {mu}N mm{sup -1} h{sup -1}. For the forewings of a single butterfly, the experiment was performed over a period of 1 week, and the results show that wing mass declined exponentially by 52.2% with a time constant of 30.2 h until it reached a steady-state level of 2.00 mg, while wing stiffness increased exponentially by 90.7% until it reached a steady-state level of 1.70 mN mm{sup -1}. (communication)
Analytical theory for shape stiffness
无
2000-01-01
The shape stiffness of mill m is defined as the crosswise rigidity of the unit width of steel plate, that is, m=k/b. By differentiating the steel plate crown equation in the vector model of steel plate shape, a new concise equation for the shape stiffness, kc=m+q, is obtained. Furthermore, by combining the calculation equation for steel plate crown derived from Castigliano's theorem, an analytical calculation equation for the shape rigidity of rolled steel plate is derived. The correctness and practicability of the theory for the shape stiffness are demonstrated by comparing the results from the numerical calculation with the practical data of a rolling mill.
Analytical theory for shape stiffness
张进之
2000-01-01
The shape stiffness of mill m is defined as the crosswise rigidity of the unit width of steel plate, that is, m = k/b. By differentiating the steel plate crown equation in the vector model of steel plate shape, a new concise equation for the shape stiffness, kc = m + q, is obtained. Furthermore, by combining the calculation equation for steel plate crown derived from Castigliano’s theorem, an analytical calculation equation for the shape rigidity of rolled steel plate is derived. The correctness and practicability of the theory for the shape stiffness are demonstrated by comparing the results from the numerical calculation with the practical data of a rolling mill.
Ming, Xin; Han, Shu-ying; Qi, Zheng-chun; Sheng, Dong; Lian, Hong-zhen
2009-08-15
Although simple acids, replacing buffers, have been widely applied to suppress the ionization of weakly ionizable acidic analytes in reversed-phase liquid chromatography (RPLC), none of the previously reported works focused on the systematic studies about the retention behavior of the acidic solutes in this ion-suppression RPLC mode. The subject of this paper was therefore to investigate the retention behavior of monobasic weak acidic compounds using acetic, perchloric and phosphoric acids as the ion-suppressors. The apparent octanol-water partition coefficient (K" ow) was proposed to calibrate the octanol-water partition coefficient (K(ow)) of these weak acidic compounds, which resulted in a better linear correlation with log k(w), the logarithm of the hypothetical retention factor corresponding to neat aqueous fraction of hydroorganic mobile phase. This log K" ow-log k w linear correlation was successfully validated by the results of monocarboxylic acids and monohydrating phenols, and moreover by the results under diverse experimental conditions for the same solutes. This straightforward relationship not only can be used to effectively predict the retention values of weak acidic solutes combined with Snyder-Soczewinski equation, but also can offer a promising medium for directly measuring K(ow) data of these compounds via Collander equation. In addition, the influence of the different ion-suppressors on the retention of weak acidic compounds was also compared in this RPLC mode.
Csontos, József; Murphy, Richard F; Lovas, Sándor
2008-11-01
The energetics of intramolecular interactions on the conformational potential energy surface of the terminally protected N-Ac-Phe-Gly-Gly-NHMe (FGG), N-Ac-Trp-Gly-Gly-NHMe (WGG), and N-Ac-Tyr-Gly-Gly-NHMe (YGG) tripeptides was investigated. To identify the representative conformations, simulated annealing molecular dynamics (MD) and density functional theory (DFT) methods were used. The interaction energies were calculated at the BHandHLYP/aug-cc-pVTZ level of theory. In the global minima, 10%, 31%, and 10% of the stabilization energy come from weakly polar interactions, respectively, in FGG, WGG, and YGG. In the prominent cases 46%, 62%, and 46% of the stabilization energy is from the weakly polar interactions, respectively, in FGG, WGG, and YGG. On average, weakly polar interactions account for 15%, 34%, and 9% of the stabilization energies of the FGG, WGG, and YGG conformers, respectively. Thus, weakly polar interactions can make an important energetic contribution to protein structure and function.
Level Classifications of Foundation Stiffness
Ibsen, Lars Bo; Liingaard, Morten
2007-01-01
This article describes a foundation module developed and implemented in both HAWC and FLEX capable of to simulate the frequency dependent stiffness and damping of foundations e.g. pile, gravitation and bucket foundations.......This article describes a foundation module developed and implemented in both HAWC and FLEX capable of to simulate the frequency dependent stiffness and damping of foundations e.g. pile, gravitation and bucket foundations....
Weak Galois and Weak Cocleft Coextensions
J.N. Alonso (A)lvarez; J.M. Fernández Vilaboa; R. González Rodríguez; A.B. Rodríguez Raposo
2007-01-01
For a weak entwining structure (A, C,ψ) living in a braided monoidal category with equalizers and coequalizers, we formulate the notion of weak A-Galois coextension with normal basis and we show that these Galois coextensions are equivalent to the weak A-cocleft coextensions introduced by the authors.
Kaplan, L
1998-01-01
We examine the consequences of classical ergodicity for the localization properties of individual quantum eigenstates in the classical limit. We note that the well known Schnirelman result is a weaker form of quantum ergodicity than the one implied by random matrix theory. This suggests the possibility of systems with non-gaussian random eigenstates which are nonetheless ergodic in the sense of Schnirelman and lead to ergodic transport in the classical limit. These we call "weakly quantum ergodic.'' Indeed for a class of "slow ergodic" classical systems, it is found that each eigenstate becomes localized to an ever decreasing fraction of the available state space, in the semiclassical limit. Nevertheless, each eigenstate in this limit covers phase space evenly on any classical scale, and long-time transport properties betwen individual quantum states remain ergodic due to the diffractive effects which dominate quantum phase space exploration.
Arterial Stiffness: Recommendations and Standardization
Townsend, Raymond R.
2017-01-01
The use of arterial stiffness measurements in longitudinal cohorts of normal populations, hypertensive patients, diabetic patients, healthy elderly, and patients on hemodialysis have confirmed the value of this important measure of arterial health, and established its complementary role to measures of blood pressure. Its contribution to understanding cardiovascular and mortality risk beyond blood pressure measurements has moved measures of arterial stiffness into the ranks of factors such as elevated cholesterol, diabetes, and left ventricular hypertrophy in considering cardiovascular risk. The recent international collaboration's publication of reference ranges for normal people and those with hypertension, along with the American Heart Association's recent scientific statement on standardizing arterial stiffness measurements are important aspects to consider in future studies employing these valuable methods, particularly as interventions that not only lower blood pressure but improve arterial function are tested in the clinical arena. PMID:28275588
Jirar Topouchian
2007-09-01
Full Text Available Jirar Topouchian1, Ramzi El Feghali1, Bruno Pannier1, Shuyu Wang2, Feng Zhao3, Karel Smetana4, Koon Teo3, Roland Asmar11The CardioVascular Institute, Paris, France; 2Beijing Clinical Trial and Research Center, Beijing, China; 3Population Health Research Institute, Hamilton, Canada; 4Vojenska nemocnice Plzen, Pizen, Czech RepublicAbstract: The degree of arterial stiffness is correlated with the risk of cardiovascular diseases and it is a powerful predictor for morbidity and mortality. Studies have shown that arterial stiffness reduction is associated with an improvement in survival. Reduction of arterial stiffness by pharmacological drugs varies according to the drugs and doses used and duration of treatment. This effect on the arteries differs among the various classes of drugs and among individual drugs in the same class. Quantification of the stiffness and other properties of the arterial wall can be used to monitor the responses to therapy in individuals with hypertension and other cardiovascular diseases. These measures can then be used as surrogate markers for the risk of clinical events. Inhibition of the renin-angiotensin system (RAS is associated with an important decrease in cardiovascular risk. Findings from clinical trials support the hypothesis that the protective effects of RAS inhibition are partly independent from blood pressure reduction and related to several mechanisms including vascular protective effects. The aim of the TRanscend Arterial stiffNess Substudy (TRANS is to assess the effect of an angiotensin II receptor blocker (ARB, telmisartan, on the arterial stiffness in a subgroup of patients from the Telmisartan Randomized Assessment Study in aCE iNtolerant subjects with cardiovascular Disease (TRANSCEND trial. The TRANSCEND trial is an international, multicenter, randomized double blind placebo controlled trial of telmisartan that enrolled patients at high risk for cardiovascular events. Some clinical baseline data of the
Lase Ultrasonic Web Stiffness tester
Tim Patterson, Ph.D., IPST at Ga Tech
2009-01-12
The objective is to provide a sensor that uses non-contact, laser ultrasonics to measure the stiffness of paper during the manufacturing process. This will allow the manufacturer to adjust the production process in real time, increase filler content, modify fiber refining and as result produce a quality product using less energy. The sensor operates by moving back and forth across the paper web, at pre-selected locations firing a laser at the sheet, measuring the out-of-plane velocity of the sheet then using that measurement to calculate sheet stiffness.
Dynamic stiffness of suction caissons
Ibsen, Lars Bo; Liingaard, Morten; Andersen, Lars
This report concerns the dynamic soil-structure interaction of steel suction caissons applied as foundations for offshore wind turbines. An emphasis is put on torsional vibrations and coupled sliding/rocking motion, and the influence of the foundation geometry and the properties of the surrounding...... soil is examined. The soil is simplified as a homogenous linear viscoelastic material and the dynamic stiffness of the suction caisson is expressed in terms of dimensionless frequency-dependent coefficients corresponding to the different degrees of freedom. The dynamic stiffness coefficients...
An investigation on the behaviour and stiffness of reinforced concrete slabs subjected to torsion
Nguyen, M. C. T.; Pham, P. T.
2017-01-01
This paper presents an investigation on RC slab under torsion, by both experiment and finite element analysis. The torsion tests were done on three similar square RC slabs with dimensions of 1900×1900×150 mm. The behaviour of slabs at pre-cracking and post-cracking of concrete phases were investigated, via Load-displacement, twisting moment-curvature relationships, and torsional stiffness of slabs. The experimental results are compared with the FEA and the results in literatures. The torsional stiffness of slab at the phase of concrete cracked and steel yield is about 1/25 of the stiffness at the pre-cracking phase.
Biomechanical Effects of Stiffness in Parallel With the Knee Joint During Walking.
Shamaei, Kamran; Cenciarini, Massimo; Adams, Albert A; Gregorczyk, Karen N; Schiffman, Jeffrey M; Dollar, Aaron M
2015-10-01
The human knee behaves similarly to a linear torsional spring during the stance phase of walking with a stiffness referred to as the knee quasi-stiffness. The spring-like behavior of the knee joint led us to hypothesize that we might partially replace the knee joint contribution during stance by utilizing an external spring acting in parallel with the knee joint. We investigated the validity of this hypothesis using a pair of experimental robotic knee exoskeletons that provided an external stiffness in parallel with the knee joints in the stance phase. We conducted a series of experiments involving walking with the exoskeletons with four levels of stiffness, including 0%, 33%, 66%, and 100% of the estimated human knee quasi-stiffness, and a pair of joint-less replicas. The results indicated that the ankle and hip joints tend to retain relatively invariant moment and angle patterns under the effects of the exoskeleton mass, articulation, and stiffness. The results also showed that the knee joint responds in a way such that the moment and quasi-stiffness of the knee complex (knee joint and exoskeleton) remains mostly invariant. A careful analysis of the knee moment profile indicated that the knee moment could fully adapt to the assistive moment; whereas, the knee quasi-stiffness fully adapts to values of the assistive stiffness only up to ∼80%. Above this value, we found biarticular consequences emerge at the hip joint.
Liu, R. M.; Zhuo, W. Z.; Chen, J.; Qin, M. H.; Zeng, M.; Lu, X. B.; Gao, X. S.; Liu, J.-M.
2017-07-01
We study the thermal phase transition of the fourfold degenerate phases (the plaquette and single-stripe states) in the two-dimensional frustrated Ising model on the Shastry-Sutherland lattice using Monte Carlo simulations. The critical Ashkin-Teller-like behavior is identified both in the plaquette phase region and the single-stripe phase region. The four-state Potts critical end points differentiating the continuous transitions from the first-order ones are estimated based on finite-size-scaling analyses. Furthermore, a similar behavior of the transition to the fourfold single-stripe phase is also observed in the anisotropic triangular Ising model. Thus, this work clearly demonstrates that the transitions to the fourfold degenerate states of two-dimensional Ising antiferromagnets exhibit similar transition behavior.
Predicting phase shift of elastic waves in pipes due to fluid flow and imperfections
Thomsen, Jon Juel; Dahl, Jonas; Fuglede, Niels
2009-01-01
Flexural vibrations of a fluid-conveying pipe is investigated, with special consideration to the spatial shift in phase caused by fluid flow and various imperfections, e.g., non-ideal supports, non-uniform stiffness or mass, non-proportional damping, weak nonlinearity, and flow pulsation. This is......Flexural vibrations of a fluid-conveying pipe is investigated, with special consideration to the spatial shift in phase caused by fluid flow and various imperfections, e.g., non-ideal supports, non-uniform stiffness or mass, non-proportional damping, weak nonlinearity, and flow pulsation....... This is relevant for understanding wave propagation in elastic media in general, and for the design and trouble-shooting of phase-shift measuring devices such as Coriolis mass flowmeters in particular. A multiple time scaling perturbation analysis is employed for a simple model of a fluid-conveying pipe...
Effects of Stiffness on Short, Semiflexible Homopolymer Chains
Seaton, Daniel T.; Schnabel, Stefan; Bachmann, Michael; Landau, David P.
2012-08-01
Conformational and transition behavior of finite, semiflexible homopolymers is studied using an extension of the Wang-Landau algorithm. Generation of a flat distribution in the sampling parameters energy and stiffness allows for efficient investigation of transitions between various conformational phases. Of particular importance is the ability to predict behavior for a given stiffness value, where three classes of minimum energy conformations are expected: Solid-globular, rod-like and toroidal. We present first results highlighting the behavior of a single N = 20 length chain.
微弱信号相位检测的自适应陷波法及其应用%Adaptive Wave Trap in Phase Detection for Weak Signal and Its Application
李东; 蔡湘平
2012-01-01
针对微弱信号因噪声影响造成剧烈的相位变化,采用常规的方法无法检测出其相位的现象,提出了一种自适应陷波方法.该方法采用自适应陷波算法来滤出期望信号,再对陷波后信号进行带宽压缩以提高信噪比,从而准确检测出信号的相位.根据检测方法,研制出以数字信号处理器为核心的检测系统,并应用此系统检测石英晶体输出的微弱信号的相位差.试验表明,对于信噪比小于-60dB的微弱信号,系统相位检测精度达到2×10-6.%Affected by noise, the phase of weak signal often changes fiercely and can' t be detected with conventional method, thus the method of adaptive wave trap (notching filtering) is proposed. By adopting adaptive wave trap algorithm, the expected signal is filtered out, and then the bandwidth of signal after wave trap is compressed to improve signal-to-noise ratio, and thus the phase of signal is detected accurately. The detection system with the digital signal as the core is developed in accordance with the detection method, and the phase difference of the weak signal output by quartz crystal is detected by this system. The experiment verifies that to the weak signal that SNR is less than - 60 dB, the phase detection accuracy of the system can reach 2 × 10-6.
Yong Hua LI; Hai Bin KAN; Bing Jun YU
2004-01-01
In this paper, a special kind of partial algebras called projective partial groupoids is defined.It is proved that the inverse image of all projections of a fundamental weak regular *-semigroup under the homomorphism induced by the maximum idempotent-separating congruence of a weak regular *-semigroup has a projective partial groupoid structure. Moreover, a weak regular *-product which connects a fundamental weak regular *-semigroup with corresponding projective partial groupoid is defined and characterized. It is finally proved that every weak regular *-product is in fact a weak regular *-semigroup and any weak regular *-semigroup is constructed in this way.
S Sarkar; C V Tomy; A D Thakur; G Balakrishnan; D McK Paul; S Ramakrishnan; A K Grover
2006-01-01
We have studied metastability effects pertaining to the peak effect (PE) in critical current density (c) via isofield scans in AC susceptibility measurements in a weakly pinned single crystal of Yb3Rh4Sn13 (c(0) ≈ 7.6 K). The order-disorder transition in this specimen proceeds in a multi-step manner. The phase coexistence regime between the onset temperature of the PE and the spinodal temperature (where metastability effects cease) seems to comprise two parts, where ordered and disordered regions dominate the bulk behavior, respectively. The PE line in the vortex phase diagram is argued to terminate at the low field end at a critical point in the elastic (Bragg) glass phase.
Biomechanics of uphill walking using custom ankle-foot orthoses of three different stiffnesses.
Haight, Derek J; Russell Esposito, Elizabeth; Wilken, Jason M
2015-03-01
Ankle-foot orthoses (AFOs) can provide support and improve walking ability in individuals with plantarflexor weakness. Passive-dynamic AFO stiffness can be optimized for over-ground walking, however little research exists for uphill walking, when plantarflexor contributions are key. Compare uphill walking biomechanics (1) between dynamic AFO users and able-bodied control subjects. (2) between injured and sound limbs (3) across different AFO stiffnesses. Twelve patients with unilateral limb-salvage and twelve matched, able-bodied controls underwent biomechanical gait analysis when walking up a 10° incline. Three AFO stiffnesses were tested in the patient group: Nominal (clinically prescribed), Compliant (20% less stiff), and Stiff (20% more stiff). AFO users experienced less ankle motion and power generation, lower knee extensor moments, and greater hip flexion and power generation than controls during uphill walking. Despite these deviations, they walked at equivalent self-selected velocities and stride lengths. Asymmetries were present at the ankle and knee with decreased ankle motion and power, and lower knee extensor moments on the AFO limb. Stiffer AFOs increased knee joint flexion but a 40% range in AFO stiffness had few other effects on gait. Therefore, a wide range of clinically prescribed AFO stiffnesses may adequately assist uphill walking. Published by Elsevier B.V.
Explicit Time-Stepping for Stiff ODEs
Eriksson, Kenneth; Logg, Anders; 10.1137/S1064827502409626
2012-01-01
We present a new strategy for solving stiff ODEs with explicit methods. By adaptively taking a small number of stabilizing small explicit time steps when necessary, a stiff ODE system can be stabilized enough to allow for time steps much larger than what is indicated by classical stability analysis. For many stiff problems the cost of the stabilizing small time steps is small, so the improvement is large. We illustrate the technique on a number of well-known stiff test problems.
Axial Dynamic Stiffness of Tubular Piles in Viscoelastic Soil
Mehdi Bayat
2016-09-01
Full Text Available Large offshore wind turbines are founded on jacket structures. In this study, an elastic full-space jacket structure foundation in an elastic and viscoelastic medium is investigated by using boundary integral equations. The jacket structure foundation is modeled as a hollow, long circular cylinder when the dynamic vertical excitation is applied. The smooth surface along the entire interface is considered. The Betti reciprocal theorem along with Somigliana’s identity and Green’s function are employed to drive the dynamic stiffness of jacket structures. Modes of the resonance and anti-resonance are presented in series of Bessel’s function. Important responses, such as dynamic stiffness and phase angle, are compared for different values of the loss factor as the material damping, Young’s modulus and Poisson’s ratio in a viscoelastic soil. Results are verified with known results reported in the literature. It is observed that the dynamic stiffness fluctuates with the loss factor, and the turning point is independent of the loss factor while the turning point increases with load frequency. It is seen that the non-dimensional dynamic stiffness is dependent on Young’s modulus and Poisson’s ratio, whilst the phase angle is independent of the properties of the soil. It is shown that the non-dimensional dynamic stiffness changes linearly with high-frequency load. The conclusion from the results of this study is that the material properties of soil are significant parameters in the dynamic stiffness of jacket structures, and the presented approach can unfold the behavior of soil and give an approachable physical meaning for wave propagation.
Shoulder Stiffness : Current Concepts and Concerns
Itoi, Eiji; Arce, Guillermo; Bain, Gregory I.; Diercks, Ronald L.; Guttmann, Dan; Imhoff, Andreas B.; Mazzocca, Augustus D.; Sugaya, Hiroyuki; Yoo, Yon-Sik
2016-01-01
Shoulder stiffness can be caused by various etiologies such as immobilization, trauma, or surgical interventions. The Upper Extremity Committee of ISAKOS defined the term "frozen shoulder" as idiopathic stiff shoulder, that is, without a known cause. Secondary stiff shoulder is a term that should be
Energy-Efficient Variable Stiffness Actuators
Visser, Ludo C.; Carloni, Raffaella; Stramigioli, Stefano
2011-01-01
Variable stiffness actuators are a particular class of actuators that is characterized by the property that the apparent output stiffness can be changed independent of the output position. To achieve this, variable stiffness actuators consist of a number of elastic elements and a number of actuated
Precision Metrology Using Weak Measurements
Zhang, Lijian; Datta, Animesh; Walmsley, Ian A.
2015-05-01
Weak values and measurements have been proposed as a means to achieve dramatic enhancements in metrology based on the greatly increased range of possible measurement outcomes. Unfortunately, the very large values of measurement outcomes occur with highly suppressed probabilities. This raises three vital questions in weak-measurement-based metrology. Namely, (Q1) Does postselection enhance the measurement precision? (Q2) Does weak measurement offer better precision than strong measurement? (Q3) Is it possible to beat the standard quantum limit or to achieve the Heisenberg limit with weak measurement using only classical resources? We analyze these questions for two prototypical, and generic, measurement protocols and show that while the answers to the first two questions are negative for both protocols, the answer to the last is affirmative for measurements with phase-space interactions, and negative for configuration space interactions. Our results, particularly the ability of weak measurements to perform at par with strong measurements in some cases, are instructive for the design of weak-measurement-based protocols for quantum metrology.
Precision metrology using weak measurements.
Zhang, Lijian; Datta, Animesh; Walmsley, Ian A
2015-05-29
Weak values and measurements have been proposed as a means to achieve dramatic enhancements in metrology based on the greatly increased range of possible measurement outcomes. Unfortunately, the very large values of measurement outcomes occur with highly suppressed probabilities. This raises three vital questions in weak-measurement-based metrology. Namely, (Q1) Does postselection enhance the measurement precision? (Q2) Does weak measurement offer better precision than strong measurement? (Q3) Is it possible to beat the standard quantum limit or to achieve the Heisenberg limit with weak measurement using only classical resources? We analyze these questions for two prototypical, and generic, measurement protocols and show that while the answers to the first two questions are negative for both protocols, the answer to the last is affirmative for measurements with phase-space interactions, and negative for configuration space interactions. Our results, particularly the ability of weak measurements to perform at par with strong measurements in some cases, are instructive for the design of weak-measurement-based protocols for quantum metrology.
Zeng, Y. P.; Sharpe, S. W.; Reifschneider, D.; Wittig, C.; Beaudet, R. A.
1990-07-01
Pulsed, slotted nozzle expansions and tunable diode lasers were employed in the present recording of the rovibrational absorption spectra of weakly-bonded complexes of N2O with HF, DF, HCl, and HBr in the nu(3) region of N2O; the fast-scan technique used yielded 4000 resolution elements with a single opening of the nozzle. Of the two known NH- and OH-bonded isomers of N2O-HF, only linear ONN-HF was detected. High resolution spectra of NNO-HCl and NNO-HBr are presented. The qualitative changes observed in NNO-HX geometries and force fields are attributed to the competing effects of hydrogen-bonding and dispersion forces.
Singh, Santosh K.; Vaishnav, Jamuna K.; Das, Aloke
2016-09-01
In this study, interplay between a strong hydrogen bond and a very weak n → π* interaction has been probed through experiment for the first time. We have used resonant 2-photon ionization, Infrared-ultraviolet double resonance spectroscopy, and quantum chemistry calculation to determine the structures of 7-azaindole⋯2,6-difluoropyridine and 7-azaindole⋯2,3,5,6-tetrafluororpyridine complexes, which are stabilized by both hydrogen bonding and n → π* interaction. The structures of the complexes studied in the present work have been compared with the double hydrogen bonded (N-H⋯N and C-H⋯N) planar structure of 7-azaindole⋯2-fluoropyridine. It has been found that the strength of the N-H⋯N hydrogen bond in the 7-azaindole⋯2,6-substituted fluoropyridines is affected due to several factors. The main reason for huge reduction in the strength of this N-H⋯N hydrogen bond in these complexes is due to loss of the C-H⋯N hydrogen bond, through substitution of fluorine atoms in 2 and 6 positions, which induces major structural changes by bending the hydrogen bond and introducing the n → π* interaction. Effect of fluorination as well as presence of the n → π* interaction in these complexes also contributes to the reduction of the strength of the N-H⋯N interaction. Although it is difficult to quantify the role of the n → π* interaction to affect the strength of the hydrogen bond, observation of the structures, where a strong hydrogen bond and a weak n → π* interaction co-exist, is confirmed.
Negative stiffness in gear contact
Půst L.
2015-12-01
Full Text Available The tooth contact stiffness is very often included in dynamic mathematical models of gear drives. It is an important value for calculation of torsion eigenfrequencies as well as the dynamic properties of the whole transmission systems. Planetary gear drives have several advantages over simple parallel axis gears, especially due to theirs compact design and great torque-to-weight ratio caused by multiple parallel paths. However, the dimensional or mounting errors can cause that some planets have the tendency to take more load than the others. One of the ways how to improve load sharing is the application of flexible planetary pins or by using a free central wheel. However in such cases, the wheels motion is defined in one rotation coordinate and two translation coordinates — tangential and radial. The reaction force at radial change of axis distance is usually neglected. The focus of this contribution is to derive the stiffness of this radial connection and to analyse the influence of radial stiffness on planetary gear dynamics.
An integrated design of quasi-zero stiffness mechanism
Ahn, Hyeong Joon; Lim, Sung Hun; Park, Chang Kun [Soongsil University, Seoul (Korea, Republic of)
2016-03-15
Nonlinear Quasi-zero stiffness (QZS) mechanisms were studied to overcome the weakness of linear isolators. This paper presents an integrated design of the QZS mechanism. First, various types of QZS vibration mechanisms are analyzed and a generalized model for QZS mechanisms is derived. The generalized model consists of two main parts: link and horizontal spring. The motion equation of the QZS mechanism is a Duffing equation with nonlinear stiffness. Based on the generalized model, the design problem of the QZS mechanism is converted into the kinematic design of a link element. For simplicity, the link is generalized with a cam-roller mechanism. The integrated design approach shows that the QZS mechanism can have desired QZS characteristics with properly designed cam geometry.
Lower limb joint kinetics and ankle joint stiffness in the sprint start push-off.
Charalambous, Laura; Irwin, Gareth; Bezodis, Ian N; Kerwin, David
2012-01-01
Sprint push-off technique is fundamental to sprint performance and joint stiffness has been identified as a performance-related variable during dynamic movements. However, joint stiffness for the push-off and its relationship with performance (times and velocities) has not been reported. The aim of this study was to quantify and explain lower limb net joint moments and mechanical powers, and ankle stiffness during the first stance phase of the push-off. One elite sprinter performed 10 maximal sprint starts. An automatic motion analysis system (CODA, 200 Hz) with synchronized force plates (Kistler, 1000 Hz) collected kinematic profiles at the hip, knee, and ankle and ground reaction forces, providing input for inverse dynamics analyses. The lower-limb joints predominately extended and revealed a proximal-to-distal sequential pattern of maximal extensor angular velocity and positive power production. Pearson correlations revealed relationships (P < 0.05) between ankle stiffness (5.93 ± 0.75 N x m x deg(-1)) and selected performance variables. Relationships between negative power phase ankle stiffness and horizontal (r = -0.79) and vertical (r = 0.74) centre of mass velocities were opposite in direction to the positive power phase ankle stiffness (horizontal: r = 0.85; vertical: r = -0.54). Thus ankle stiffness may affect the goals of the sprint push-off in different ways, depending on the phase of stance considered.
Cofinitely weak supplemented modules
Alizade, Rafail; Büyükaşık, Engin
2003-01-01
We prove that a module M is cofinitely weak supplemented or briefly cws (i.e., every submodule N of M with M/N finitely generated, has a weak supplement) if and only if every maximal submodule has a weak supplement. If M is a cws-module then every M-generated module is a cws-module. Every module is cws if and only if the ring is semilocal. We study also modules, whose finitely generated submodules have weak supplements.
Measurement and Treatment of Passive Muscle Stiffness
Kirk, Henrik
This PhD thesis is based on research conducted at the University of Copenhagen and Helene Elsass Center from 2012 to 2015. Measurements and treatment of passive muscle stiffness in people with cerebral palsy (CP) comprise the focus of the thesis. The thesis summarizes the results from four studies...... stiffness. I introduce how to evaluate and distinguish between passive muscle stiffness and reflex-mediated stiffness in research and in clinical practice. Furthermore, I present ”the Portable Spasticity Assessment Device”, which was developed as a part of the PhD study. I discuss the validity......-mediated stiffness was considered a major problem. However, this study shows that significantly reduced RFD and increased passive muscle stiffness, rather than reflex-mediated stiffness, are the major contributors to impaired gait function in adults with CP, compared with neurologically healthy subjects. The third...
Berg, Rolf W.
1978-01-01
torsions and other noncubic features play a role, especially in spectra at low temperatures. Possible site symmetries of the [PtCl6]2− ion, which cannot have strictly Oh symmetry in either phase, have been deduced. The spectra of a mixed Pt : Te compound showed that the hexachlorometallate anions vibrate...... approximately independent of each other. The results have been compared with von der Ohe's recent extensive low temperature Raman study on protonated compounds with M=U, Sn, and Zr, and his conclusions are discussed. It is shown that crystals of this kind can be characterized by methyl–chlorine interaction...... and it is suggested that the phase transitions are caused by an ordering of rotationally disordered methyl groups via the formation of weak C–H···Cl hydrogen bonds at low temperatures. The transition temperatures and hence the interactions are shown to depend on both the kind of hydrogen isotope and metal present...
丁夏畦; 罗佩珠
2004-01-01
In this paper the authors introduce some new ideas on generalized numbers and generalized weak functions. They prove that the product of any two weak functions is a generalized weak function. So in particular they solve the problem of the multiplication of two generalized functions.
Vortex phase diagram studies in the weakly pinned single crystals of YNi2B2C and LuNi2B2C
D Jaiswal-Nagar; D Pal; M R Eskildsen; P C Canfield; H Takeya; S Ramakrishnan; A K Grover
2006-01-01
We present a study of magnetization measurements performed on the single crystals of YNi2B2C and LuNi2B2C. For both the compounds, we find flux jumps in magnetisation values in the respective field regions, where the structural transitions in the flux line lattice symmetry have been reported in these systems via the small angle neutron scattering experiments. The magnetisation hysteresis loops and the AC susceptibility measurements show pronounced peak effect as well as second magnetisation peak anomaly for both YNi2B2C and LuNi2B2C. Based on these results, a vortex phase diagram has been constructed for YNi2B2C for $H \\Arrowvert c$ depicting different glassy phases of the vortex matter.
Wu, Guoliang; Wang Co-First, Shujing; Tian, Zhou; Zhang, Ning; Sheng, Han; Dai, Weiguo; Qian, Feng
2017-07-25
Liquid-liquid phase separation (LLPS) has long been observed during the physical stability investigation of therapeutic protein formulations. The buffer conditions and the presence of various excipients are thought to play important roles in the formulation development of monoclonal antibodies (mAbs). In this study, the effects of several small-molecule excipients (histidine, alanine, glycine, sodium phosphate, sodium chloride, sorbitol and sucrose) with diverse physical-chemical properties on LLPS of a model IgG1 (JM2) solutions were investigated by multiple techniques, including UV-vis spectroscopy, circular dichroism, differential scanning calorimetry/fluorimetry, size exclusion chromatography and dynamic light scattering. The LLPS of JM2 was confirmed to be a thermodynamic equilibrium process with no structural changes or irreversible aggregation of proteins. Phase diagrams of various JM2 formulations were constructed, suggesting that the phase behavior of JM2 was dependent on the solution pH, ionic strength and the presence of other excipients such as glycine, alanine, sorbitol and sucrose. Furthermore, we demonstrated that for this mAb, the interaction parameter (kD) determined at low protein concentration appeared to be a good predictor for the occurrence of LLPS at high concentration. Copyright © 2017. Published by Elsevier B.V.
The Geometry And Significance Of Weak Energy
Parks, A D
2000-01-01
Summary: The theory of weak values for quantum mechanical observables has come to serve as a useful basis for contemporary discussions concerning such varied topics as the tunnelling-time controversy and quantum stochastic processes. An intrinsic complex-valued weak energy has recently been observed experimentally and reported in the literature. In this paper it is shown that: (a) the real and imaginary valued parts of this weak energy have geometric interpretations related to a phase acquired from parallel transport in Hilbert space and the variational dynamics occurring in the associated projective Hilbert space, respectively; (b) the weak energy defines functions which translate correlation amplitudes and probabilities in time; (c) correlation probabilities can be controlled by manipulating the weak energy and there exists a condition of weak stationarity that guarantees their time invariance; and (d) a time-weak energy uncertainty relation of the usual form prevails when a suitable set of dynamical constr...
Voluntary control of human jaw stiffness.
Shiller, Douglas M; Houle, Guillaume; Ostry, David J
2005-09-01
Recent studies of human arm movement have suggested that the control of stiffness may be important both for maintaining stability and for achieving differences in movement accuracy. In the present study, we have examined the voluntary control of postural stiffness in 3D in the human jaw. The goal is to address the possible role of stiffness control in both stabilizing the jaw and in achieving the differential precision requirements of speech sounds. We previously showed that patterns of kinematic variability in speech are systematically related to the stiffness of the jaw. If the nervous system uses stiffness control as a means to regulate kinematic variation in speech, it should also be possible to show that subjects can voluntarily modify jaw stiffness. Using a robotic device, a series of force pulses was applied to the jaw to elicit changes in stiffness to resist displacement. Three orthogonal directions and three magnitudes of forces were tested. In all conditions, subjects increased the magnitude of jaw stiffness to resist the effects of the applied forces. Apart from the horizontal direction, greater increases in stiffness were observed when larger forces were applied. Moreover, subjects differentially increased jaw stiffness along a vertical axis to counteract disturbances in this direction. The observed changes in the magnitude of stiffness in different directions suggest an ability to control the pattern of stiffness of the jaw. The results are interpreted as evidence that jaw stiffness can be adjusted voluntarily, and thus may play a role in stabilizing the jaw and in controlling movement variation in the orofacial system.
Superfluid stiffness of a driven dissipative condensate with disorder.
Janot, Alexander; Hyart, Timo; Eastham, Paul R; Rosenow, Bernd
2013-12-01
Observations of macroscopic quantum coherence in driven systems, e.g. polariton condensates, have strongly stimulated experimental as well as theoretical efforts during the last decade. We address the question of whether a driven quantum condensate is a superfluid, allowing for the effects of disorder and its nonequilibrium nature. We predict that for spatial dimensions d<4 the superfluid stiffness vanishes once the condensate exceeds a critical size, and treat in detail the case d=2. Thus a nonequilibrium condensate is not a superfluid in the thermodynamic limit, even for weak disorder, although superfluid behavior would persist in small systems.
GREEN＇S FUNCTION AND EFFECTIVE ELASTIC STIFFNESS TENSOR FOR ARBITRARY AGGREGATES OF CUBIC CRYSTALS
HuangMojia; ZhengChaomei
2004-01-01
A closed but approximate formula of Green's function for an arbitrary aggregate of cubic crystallites is given to derive the effective elastic stiffness tensor of the polycrystal. This formula, which includes three elastic constants of single cubic crystal and five texture coefficients,accounts for the effects of the orientation distribution function (ODF) up to terms linear in the texture coefficients. Thus it is expected that our formula would be applicable to arbitrary aggregates with weak texture or to materials such as aluminum whose single crystal has weak anisotropy.Three examples are presented to compare predictions from our formula with those from Nishioka and Lothe's formula and Synge's contour integral through numerical integration. As an application of Green's function, we briefly describe the procedure of deriving the effective elastic stiffness tensor for an orthorhombic aggregate of cubic crystallites. The comparison of the computational results given by the finite element method and our effective elastic stiffness tensor is made by an example.
Ventosa, Sergi; Romanowicz, Barbara
2015-11-01
Resolving the topography of the core-mantle boundary (CMB) and the structure and composition of the D″ region is key to improving our understanding of the interaction between the Earth's mantle and core. Observations of traveltimes and amplitudes of short-period teleseismic body waves sensitive to lowermost mantle provide essential constraints on the properties of this region. Major challenges are low signal-to-noise ratio of the target phases and interference with other mantle phases. In a previous paper (Part I), we introduced the slant-stacklet transform to enhance the signal of the core-reflected (PcP) phase and to isolate it from stronger signals in the coda of the P wave. Then we minimized a linear misfit between P and PcP waveforms to improve the quality of PcP-P traveltime difference measurements as compared to standard cross-correlation methods. This method significantly increases the quantity and the quality of PcP-P traveltime observations available for the modelling of structure near the CMB. Here we illustrate our approach in a series of regional studies of the CMB and D″ using PcP-P observations with unprecedented resolution from high-quality dense arrays located in North America and Japan for events with magnitude Mw>5.4 and distances up to 80°. In this process, we carefully analyse various sources of errors and show that mantle heterogeneity is the most significant. We find and correct bias due to mantle heterogeneities that is as large as 1 s in traveltime, comparable to the largest lateral PcP-P traveltime variations observed. We illustrate the importance of accurate mantle corrections and the need for higher resolution mantle models for future studies. After optimal mantle corrections, the main signal left is relatively long wavelength in the regions sampled, except at the border of the Pacific large-low shear velocity province (LLSVP). We detect the northwest border of the Pacific LLSVP in the western Pacific from array observations in
Leg and Joint Stiffness in Children with Spastic Diplegic Cerebral Palsy during Level Walking.
Ting-Ming Wang
Full Text Available Individual joint deviations are often identified in the analysis of cerebral palsy (CP gait. However, knowledge is limited as to how these deviations affect the control of the locomotor system as a whole when striving to meet the demands of walking. The current study aimed to bridge the gap by describing the control of the locomotor system in children with diplegic CP in terms of their leg stiffness, both skeletal and muscular components, and associated joint stiffness during gait. Twelve children with spastic diplegia CP and 12 healthy controls walked at a self-selected pace in a gait laboratory while their kinematic and forceplate data were measured and analyzed during loading response, mid-stance, terminal stance and pre-swing. For calculating the leg stiffness, each of the lower limbs was modeled as a non-linear spring, connecting the hip joint center and the corresponding center of pressure, with varying stiffness that was calculated as the slope (gradient of the axial force vs. the deformation curve. The leg stiffness was further decomposed into skeletal and muscular components considering the alignment of the lower limb. The ankle, knee and hip of the limb were modeled as revolute joints with torsional springs whose stiffness was calculated as the slope of the moment vs. the angle curve of the joint. Independent t-tests were performed for between-group comparisons of all the variables. The CP group significantly decreased the leg stiffness but increased the joint stiffness during stance phase, except during terminal stance where the leg stiffness was increased. They appeared to rely more on muscular contributions to achieve the required leg stiffness, increasing the muscular demands in maintaining the body posture against collapse. Leg stiffness plays a critical role in modulating the kinematics and kinetics of the locomotor system during gait in the diplegic CP.
Stiffness estimation of a parallel kinematic machine
无
2001-01-01
This paper presents a simple yet comprehensive approach to quickly estimating the stiff-ness of a tripod-based parallel kinematic machine. This approach can be implemented in two steps. Inthe first step, the machine structure is decomposed into two substructures associated with the machineframe and parallel mechanism. The stiffness models of these two substructures are formulated bymeans of virtual work principle. This is followed by the second step that enables the stiffness model ofthe machine structure as a whole to be achieved by linear superposition. The 3D representations of themachine stiffness within the usable workspace are depicted and the contributions of different componentrigidities to the machine stiffness are discussed. The result is compared with that obtained through finiteelement analysis.
Measurement and Treatment of Passive Muscle Stiffness
Kirk, Henrik
This PhD thesis is based on research conducted at the University of Copenhagen and Helene Elsass Center from 2012 to 2015. Measurements and treatment of passive muscle stiffness in people with cerebral palsy (CP) comprise the focus of the thesis. The thesis summarizes the results from four studies......, which aimed to investigate: 1) The development of a clinical method to evaluate and distinguish neural (reflex mediated stiffness) and non-neural (passive muscle stiffness) components of muscle stiffness in adults with CP by objective and reliable measurements. 2) The association between increased...... passive muscle, muscle strength and gait function in adults with CP 3) The effect of resistance training and gait training accordingly on muscle strength, passive muscle stiffness and functional gait in adults with CP. The first part of the thesis defines reflex mediated stiffness and passive muscle...
Kögel, Julius F; Linder, Thomas; Schröder, Fabian G; Sundermeyer, Jörg; Goll, Sascha K; Himmel, Daniel; Krossing, Ingo; Kütt, Karl; Saame, Jaan; Leito, Ivo
2015-04-01
Fluoro- and perfluoralkylsulfonyl pentafluoroanilides [HN(C6F5)(SO2X); X = F, CF3, C4F9, C8F17] are a class of imides with two different strongly electron-withdrawing substituents attached to a nitrogen atom. They are NH acids, the unsymmetrical hybrids of the well-known symmetrical bissulfonylimides and bispentafluorophenylamine. The syntheses, the structures of these perfluoroanilides, their solvates, and some selected lithium salts give rise to a structural variety beyond the symmetrical parent compounds. The acidities of representative subsets of these novel NH acids have been investigated experimentally and quantum-chemically and their gas-phase acidities (GAs) are reported, as well as the pKa values of these compounds in acetonitrile (MeCN) and DMSO solution. In quantum chemical investigations with the vertical and relaxed COSMO cluster-continuum models (vCCC/rCCC), the unusual situation is encountered that the DMSO-solvated acid Me2SO-H-N(SO2CF3)2, optimized in the gas phase (vCCC model), dissociates to Me2SO-H(+)-N(SO2CF3)2(-) during structural relaxation and full optimization with the solvation model turned on (rCCC model). This proton transfer underlines the extremely high acidity of HN(SO2CF3)2. The importance of this effect is studied computationally in DMSO and MeCN solution. Usually this effect is less pronounced in MeCN and is of higher importance in the more basic solvent DMSO. Nevertheless, the neglect of the structural relaxation upon solvation causes typical changes in the computational pKa values of 1 to 4 orders of magnitude (4-20 kJ mol(-1)). The results provide evidence that the published experimental DMSO pKa value of HN(SO2CF3)2 should rather be interpreted as the pKa of a Me2SO-H(+)-N(SO2CF3)2(-) contact ion pair.
Bae, Yong Ho; Mui, Keeley L; Hsu, Bernadette Y; Liu, Shu-Lin; Cretu, Alexandra; Razinia, Ziba; Xu, Tina; Puré, Ellen; Assoian, Richard K
2014-06-17
Tissue and extracellular matrix (ECM) stiffness is transduced into intracellular stiffness, signaling, and changes in cellular behavior. Integrins and several of their associated focal adhesion proteins have been implicated in sensing ECM stiffness. We investigated how an initial sensing event is translated into intracellular stiffness and a biologically interpretable signal. We found that a pathway consisting of focal adhesion kinase (FAK), the adaptor protein p130Cas (Cas), and the guanosine triphosphatase Rac selectively transduced ECM stiffness into stable intracellular stiffness, increased the abundance of the cell cycle protein cyclin D1, and promoted S-phase entry. Rac-dependent intracellular stiffening involved its binding partner lamellipodin, a protein that transmits Rac signals to the cytoskeleton during cell migration. Our findings establish that mechanotransduction by a FAK-Cas-Rac-lamellipodin signaling module converts the external information encoded by ECM stiffness into stable intracellular stiffness and mechanosensitive cell cycling. Thus, lamellipodin is important not only in controlling cellular migration but also for regulating the cell cycle in response to mechanical signals.
Performance Assessment of a New Variable Stiffness Probing System for Micro-CMMs
Khalid Alblalaihid
2016-04-01
Full Text Available When designing micro-scale tactile probes, a design trade-off must be made between the stiffness and flexibility of the probing element. The probe must be flexible enough to ensure sensitive parts are not damaged during contact, but it must be stiff enough to overcome attractive surface forces, ensure it is not excessively fragile, easily damaged or sensitive to inertial loads. To address the need for a probing element that is both flexible and stiff, a novel micro-scale tactile probe has been designed and tested that makes use of an active suspension structure. The suspension structure is used to modulate the probe stiffness as required to ensure optimal stiffness conditions for each phase of the measurement process. In this paper, a novel control system is presented that monitors and controls stiffness, allowing two probe stiffness values (“stiff” and “flexible” to be defined and switched between. During switching, the stylus tip undergoes a displacement of approximately 18 µm, however, the control system is able ensure a consistent flexible mode tip deflection to within 12 nm in the vertical axis. The overall uncertainty for three-dimensional displacement measurements using the probing system is estimated to be 58 nm, which demonstrates the potential of this innovative variable stiffness micro-scale probe system.
IMPACT OF OVERHEAT ON DISABLED SWIMMERS’ SKELETAL MUSCLE STIFFNESS
Prystupa Tetyana
2014-04-01
Full Text Available Contemporary athletic recovery involves the range of treatments combined with training and restitution processes and are designed to optimize rest as well as minimize the effects of sports overstrain. Sportsmen benefit enormously from recovery treatments during both preparation and competition phases as they help remove frequent pathogenic pre-start conditions which could reduce work capacity and affect adversely results achieved. Purpose: The paper is aimed to specify the impact of overheat on easing the stiffness of disabled sportspeople’s biceps muscle of arm and the central part of the deltoid muscle. It has been assumed that overheating in a Finnish sauna will facilitate muscle condition and recovery of a swimmer’s body. Material: The research involved 20 disabled swimmers - 10 competitors based in the Start sports club in Kalisz and 10 contestants based in Start sports club in Wroclaw. The Tonus-1 myotonometer was used to measure the stiffness of biceps muscle of arm (biceps brachii and the central part of the deltoid muscle (deltoideus - pars acromialic. The research was carried out in two stages: training mesocycle with no recovery and training mesocycle with recovery. The mesocycles comprised three one-week-long microcycles each. Results: The research proved the overheating to ease rest muscle stiffness . Conclusions: The upshot of the discussion was that the Finnish sauna has a tonic effect on a disable swimmer’s body. Reduction of post work-out muscle stiffness will facilitate effective recovery and bring forward next training activities.
Numerical Analysis of Plastic Gear Stiffness
无
2005-01-01
This paper established practical 3-D gear models to study the stiffness influencing factors of a loaded gear by finite element method, such as friction parameters, material properties, and gear structures. The research shows that, in elastic deformation, gear stiffness increases when sliding friction ability of contact pair decreases;meanwhile, the gear structure, especially asymmetric design in gear's shaft direction will also decrease gear stiffness.
Ambulatory arterial stiffness index: rationale and methodology
Dolan, Eamon; Li,Yan; Thijs, Lutgarde; McCormack, Patricia; Staessen, Jan A; O'Brien, Eoin; Stanton, Alice
2006-01-01
OBJECTIVES: Increased arterial stiffness is associated with the development of cardiovascular disease and may even predict its development at an early stage. Increased pulse pressure is seen as a marker of increased arterial stiffness and can be readily measured by ambulatory blood pressure monitoring. We propose another surrogate measure of arterial stiffness derived from ambulatory blood pressure monitoring that may predict cardiovascular mortality over and above pulse pressure, namely, the...
On Weakly Semicommutative Rings*
CHEN WEI-XING; CUI SHU-YING
2011-01-01
A ring R is said to be weakly scmicommutative if for any a, b ∈ R,ab = 0 implies aRb C_ Nil(R), where Nil(R) is the set of all nilpotcnt elements in R.In this note, we clarify the relationship between weakly semicommutative rings and NI-rings by proving that the notion of a weakly semicommutative ring is a proper generalization of NI-rings. We say that a ring R is weakly 2-primal if the set of nilpotent elements in R coincides with its Levitzki radical, and prove that if R is a weakly 2-primal ring which satisfies oα-condition for an endomorphism α of R (that is, ab = 0 （←→） aα(b) ＝ 0 where a, b ∈ R) then the skew polynomial ring R[π; αα]is a weakly 2-primal ring, and that if R is a ring and I is an ideal of R such that I and R/I are both weakly semicommutative then R is weakly semicommutative.Those extend the main results of Liang et al. 2007 (Taiwanese J. Math., 11(5)(2007),1359-1368) considerably. Moreover, several new results about weakly semicommutative rings and NI-rings are included.
A new approach to determine press stiffness
Arentoft, Mogens; Wanheim, Tarras
2004-01-01
A new procedure is proposed for measuring press stiffness, including separated horizontal and vertical loading of the press frame. The load can be eccentrically positioned for measuring rotational stiffnesses. Two loading devices and corresponding measuring equipment for registration of press...... deflections are designed. The press stiffness is presented as a 6 by 6 flexibility matrix. The approach has been tested by measuring the stiffness of a 5000 kN O-frame, ring element, hydraulic press, a 10000 kN O-frame, pillar element, hydraulic press and a 10000 kN O-frame, ring element mechanical press...
WAY TO DETERMINE STIFFNESS FUNCTION OF STRUCTURE
WANG De-ming; GAI Bing-zheng
2005-01-01
For calculating the stiffness function of a structure, the differential equation of the vibration of the structure was divided into the differential equation on the original stiffness function that was known, and Fredholm integral equation of the first kind on the undetermined stiffness function that was unknown. And the stable solutions of the integral equation, when the smooth factor was equal to zero, was solved by the extrapolation with p smooth factors. So the stiffness function of the structure is obtained. Applied examples show that the method is feasible and effective.
The Influence of phase-locked loop on the stability of single-phase grid-connected inverter
Zhang, Chong; Wang, Xiongfei; Blaabjerg, Frede;
2015-01-01
for avoiding the PLL induced instability in single-phase inverters. At last the relationship between PLL bandwidth and the Short Circuit Ratio (SCR) of the grid has been derived to guide the design of the PLL. Experimental results are presented in order to verify this analysis, and the resonant frequencies can...... admittance of single-phase current-controlled inverters with different grid stiffness is analyzed in this paper. It shows that the PLL introduces a negative paralleled admittance into the output admittance of the inverter, which may lead to unintentional low-order harmonic oscillation in a weak grid...
Shihab, S.; Thevenard, L.; Bardeleben, H. J. von; Gourdon, C. [CNRS, UMR7588, Institut des Nanosciences de Paris, 4 place Jussieu, 75005 Paris (France); Sorbonne Universités, UPMC Université Paris 06, UMR7588, 4 place Jussieu, 75005 Paris (France); Riahi, H. [Laboratoire Matériaux Molécules et Applications, IPEST, Université de Carthage, B.P. 51, 2075 La Marsa (Tunisia); Lemaître, A. [Laboratoire de Photonique et Nanostructures, CNRS, UPR 20, Route de Nozay, 91460 Marcoussis (France)
2015-04-06
We study the dependence of the spin stiffness constant on the phosphorus concentration in the ferromagnetic semiconductor (Ga,Mn)(As,P) with the aim of determining whether alloying with phosphorus is detrimental, neutral, or advantageous to the spin stiffness. Time-resolved magneto-optical experiments are carried out in thin epilayers. Laser pulses excite two perpendicular standing spin wave modes, which are exchange related. We show that the first mode is spatially uniform across the layer corresponding to a k≈0 wavevector. From the two frequencies and k-vector spacings we obtain the spin stiffness constant for different phosphorus concentrations using weak surface pinning conditions. The mode assessment is checked by comparison to the spin stiffness obtained from domain pattern analysis for samples with out-of-plane magnetization. The spin stiffness is found to exhibit little variation with phosphorus concentration in contradiction with ab-initio predictions.
吴恒; 阮新波; 杨东升
2014-01-01
For grid-connected inverter, the current injected into utility network has to be synchronized with the grid voltage, and Phase-Locked Loop (PLL) is widely used as an efficient approach to detect grid phase angle. The inverter uses detected grid phase angle to generate synchronized current reference, thus PLL itself acts as a part of the control loop of the inverter and it will certainly affect system stability. This article focused on the single-phase LCL-type grid-connected inverter, and presented the small signal model of PLL. Meanwhile, the impedance-based stability criterion was developed. Based on the criterion, it was pointed out that in stiff grid, where the grid impedance can be neglected, the stability of the inverter will not be affected by PLL. But if the grid is weak, PLL has strong effect on the stability of the inverter, and the effect mainly depends on the bandwidth of PLL, load condition and power factor of the inverter. In order to ensure the stability of the system, a method which design the control parameters of PLL based on phase margin requirements was also proposed in this paper. The experimental results were given to verify the validity of theoretical analysis presented above.%为了保证并网逆变器的进网电流与电网电压同步，需要通过锁相环对电网电压进行锁相，并利用检测出的电网电压相位生成电流基准。该文以单相LCL型并网逆变器为例，建立锁相环的小信号模型，并根据该模型推导并网逆变器基于阻抗的稳定判据。通过分析该判据可知，在电网阻抗可忽略不计时，锁相环对并网逆变器的稳定性无影响；当电网阻抗不可忽略时，锁相环带宽、并网电流幅值给定和输出功率因数都会影响系统的稳定。为了保证系统在弱电网下的稳定性，给出一种基于相角裕度要求的锁相环参数设计方法，并进行实验验证，实验结果证明了理论分析的正确性。
Idiopathic isolated orbicularis weakness
MacVie, O P; Majid, M A; Husssin, H M; Ung, T; Manners, R M; Ormerod, I; Pawade, J; Harrad, R A
2012-01-01
Purpose Orbicularis weakness is commonly associated with seventh nerve palsy or neuromuscular and myopathic conditions such as myotonic dystrophy and myasethenia gravis. We report four cases of idiopathic isolated orbicularis weakness. Methods All four cases were female and the presenting symptoms of ocular irritation and epiphora had been present for over 7 years in three patients. All patients had lagophthalmos and three had ectropion. Three patients underwent full investigations which excluded known causes of orbicularis weakness. Two patients underwent oribularis oculi muscle biopsy and histological confirmation of orbicularis atrophy. Results All patients underwent surgery to specifically address the orbicularis weakness with satisfactory outcomes and alleviation of symptoms in all cases. Isolated orbicularis weakness may be a relatively common entity that is frequently overlooked. Conclusion Early recognition of this condition may lead to better management and prevent patients undergoing unnecessary surgical procedures. PMID:22322997
Stiff person syndrome: a case report.
Kelly, Patricia A; Kuberski, Carolyn
2014-08-01
The case report features a patient who had a diagnosis of a common type of breast cancer with an uncommon neurologic syndrome. She had extreme pain and progressive stiffness with cognitive and functional decline. This article includes the pathogenesis and treatment options for a rare, but treatable, autoimmune disorder of malignancy called stiff person syndrome.
Arterial Stiffness and Dialysis Calcium Concentration
Fabrice Mac-Way
2011-01-01
Full Text Available Arterial stiffness is the major determinant of isolated systolic hypertension and increased pulse pressure. Aortic stiffness is also associated with increased cardiovascular morbidity and mortality in patients with chronic kidney disease, hypertension, and general population. Hemodynamically, arterial stiffness results in earlier aortic pulse wave reflection leading to increased cardiac workload and decreased myocardial perfusion. Although the clinical consequence of aortic stiffness has been clearly established, its pathophysiology in various clinical conditions still remains poorly understood. The aim of the present paper is to review the studies that have looked at the impact of dialysis calcium concentration on arterial stiffness. Overall, the results of small short-term studies suggest that higher dialysis calcium is associated with a transient but significant increase in arterial stiffness. This calcium dependant increase in arterial stiffness is potentially explained by increased vascular smooth muscle tone of the conduit arteries and is not solely explained by changes in mean blood pressure. However, the optimal DCa remains to be determined, and long term studies are required to evaluate its impact on the progression of arterial stiffness.
Determination of 6 stiffnesses for a press
Arentoft, Mogens; Eriksen, Morten; Wanheim, Tarras
2000-01-01
the workpiece will result in deflections of the press, which will decrease the tolerances of the component. At present, it is possible to measure the reaction forces from the workpiece, for instance by use of the model material technique as described in [1-2]. If the stiffness and clearances of the press...... is known too, the final dimensions can be predicted by divide the force by the stiffness and add the clearance. If the stiffness of the press is known, it is possible to optimize the orientation of the workpiece too, so the direction, in which the best tolerances is demanded, is equal to the direction...... in which the press has the highest stiffness. Furthermore, knowledge about the stiffnesses of all presses in a production system makes it possible to choose the press which best fit to a specific process....
Measurement and Treatment of Passive Muscle Stiffness
Kirk, Henrik
2016-01-01
This PhD thesis is based on research conducted at the University of Copenhagen and Helene Elsass Center from 2012 to 2015. Measurements and treatment of passive muscle stiffness in people with cerebral palsy (CP) comprise the focus of the thesis. The thesis summarizes the results from four studies......, which aimed to investigate: 1) The development of a clinical method to evaluate and distinguish neural (reflex mediated stiffness) and non-neural (passive muscle stiffness) components of muscle stiffness in adults with CP by objective and reliable measurements 2) The association between increased......, and good correlation to measurements from a stationary dynamometer. The second part of the thesis discusses the finding of a significant correlation between gait function, reduced rate of force development (RFD), and increased passive muscle stiffness in adults with CP. Previously, the reflex...
Rolling Element Bearing Stiffness Matrix Determination (Presentation)
Guo, Y.; Parker, R.
2014-01-01
Current theoretical bearing models differ in their stiffness estimates because of different model assumptions. In this study, a finite element/contact mechanics model is developed for rolling element bearings with the focus of obtaining accurate bearing stiffness for a wide range of bearing types and parameters. A combined surface integral and finite element method is used to solve for the contact mechanics between the rolling elements and races. This model captures the time-dependent characteristics of the bearing contact due to the orbital motion of the rolling elements. A numerical method is developed to determine the full bearing stiffness matrix corresponding to two radial, one axial, and two angular coordinates; the rotation about the shaft axis is free by design. This proposed stiffness determination method is validated against experiments in the literature and compared to existing analytical models and widely used advanced computational methods. The fully-populated stiffness matrix demonstrates the coupling between bearing radial, axial, and tilting bearing deflections.
Stiffness Control of Surgical Continuum Manipulators
Mahvash, Mohsen; Dupont, Pierre E.
2013-01-01
This paper introduces the first stiffness controller for continuum robots. The control law is based on an accurate approximation of a continuum robot’s coupled kinematic and static force model. To implement a desired tip stiffness, the controller drives the actuators to positions corresponding to a deflected robot configuration that produces the required tip force for the measured tip position. This approach provides several important advantages. First, it enables the use of robot deflection sensing as a means to both sense and control tip forces. Second, it enables stiffness control to be implemented by modification of existing continuum robot position controllers. The proposed controller is demonstrated experimentally in the context of a concentric tube robot. Results show that the stiffness controller achieves the desired stiffness in steady state, provides good dynamic performance, and exhibits stability during contact transitions. PMID:24273466
Leg stiffness modulation during exhaustive stretch-shortening cycle exercise.
Kuitunen, S; Kyröläinen, H; Avela, J; Komi, P V
2007-02-01
The present study examined the effects of muscle activity modulation on leg stiffness during an exhaustive stretch-shortening cycle (SSC) exercise in eight male subjects. Reaction force, electromyography (EMG) of the soleus (Sol), gastrocnemius (Ga) and vastus lateralis (VL) muscles and sledge seat position were recorded during the SSC exercise, consisting of 100 maximal intermittent drop jumps followed by a continuous submaximal jumping until exhaustion, on a sledge apparatus. Metabolic loading was determined by measuring blood lactate (La). No change was found in leg stiffness during the maximal jumps, whereas the subsequent submaximal jumping induced a significant reduction by 27+/-12% (PEMG ratio between the braking and push-off phases in Sol (r=0.81, PEMG ratio at the end of the submaximal jumping in Sol (r=-0.88, Pmodulation between the braking and push-off phases in the triceps surae muscle, particularly in Ga, plays an important role in leg stiffness adjustments during fatiguing SSC exercise. It is suggested that efficient activity modulation (i.e. high EMG ratio) of the triceps surae muscle during an intensive fatiguing SSC exercise may postpone the exhaustion and development of metabolic fatigue.
Weak decays. [Lectures, phenomenology
Wojcicki, S.
1978-11-01
Lectures are given on weak decays from a phenomenological point of view, emphasizing new results and ideas and the relation of recent results to the new standard theoretical model. The general framework within which the weak decay is viewed and relevant fundamental questions, weak decays of noncharmed hadrons, decays of muons and the tau, and the decays of charmed particles are covered. Limitation is made to the discussion of those topics that either have received recent experimental attention or are relevant to the new physics. (JFP) 178 references
Weakly asymptotically hyperbolic manifolds
Allen, Paul T; Lee, John M; Allen, Iva Stavrov
2015-01-01
We introduce a class of "weakly asymptotically hyperbolic" geometries whose sectional curvatures tend to $-1$ and are $C^0$, but are not necessarily $C^1$, conformally compact. We subsequently investigate the rate at which curvature invariants decay at infinity, identifying a conformally invariant tensor which serves as an obstruction to "higher order decay" of the Riemann curvature operator. Finally, we establish Fredholm results for geometric elliptic operators, extending the work of Rafe Mazzeo and John M. Lee to this setting. As an application, we show that any weakly asymptotically hyperbolic metric is conformally related to a weakly asymptotically hyperbolic metric of constant negative curvature.
Landau Weak Crystallization Theory and its Applications
Kats, E. I.
Aim of this lecture is to explain main features and ingredients of weak first order phase transitions between liquid-like (uniform in space) and solid-like (non-uniform with characteristic wave vector q0) states. We illustrate how this theory (traditionally termed as Landau weak crystallization theory) works. We consider two examples describing universal temperature dependence of shear viscosity in liquids, and so-called main phase transition in membranes. Our results are in a good qualitative agreement with experimental data, offering a deeper understanding of this kind of phase transitions. We discuss also why and where predicted universal effects can be masked.
Aad, Georges; Abbott, Brad; Abdallah, Jalal; Abdel Khalek, Samah; Abdelalim, Ahmed Ali; Abdinov, Ovsat; Aben, Rosemarie; Abi, Babak; Abolins, Maris; AbouZeid, Ossama; Abramowicz, Halina; Abreu, Henso; Acerbi, Emilio; Acharya, Bobby Samir; Adamczyk, Leszek; Adams, David; Addy, Tetteh; Adelman, Jahred; Adomeit, Stefanie; Adragna, Paolo; Adye, Tim; Aefsky, Scott; Aguilar-Saavedra, Juan Antonio; Agustoni, Marco; Aharrouche, Mohamed; Ahlen, Steven; Ahles, Florian; Ahmad, Ashfaq; Ahsan, Mahsana; Aielli, Giulio; Akdogan, Taylan; Åkesson, Torsten Paul Ake; Akimoto, Ginga; Akimov, Andrei; Alam, Mohammad; Alam, Muhammad Aftab; Albert, Justin; Albrand, Solveig; Aleksa, Martin; Aleksandrov, Igor; Alessandria, Franco; Alexa, Calin; Alexander, Gideon; Alexandre, Gauthier; Alexopoulos, Theodoros; Alhroob, Muhammad; Aliev, Malik; Alimonti, Gianluca; Alison, John; Allbrooke, Benedict; Allport, Phillip; Allwood-Spiers, Sarah; Almond, John; Aloisio, Alberto; Alon, Raz; Alonso, Alejandro; Alonso, Francisco; Alvarez Gonzalez, Barbara; Alviggi, Mariagrazia; Amako, Katsuya; Amelung, Christoph; Ammosov, Vladimir; Amorim, Antonio; Amram, Nir; Anastopoulos, Christos; Ancu, Lucian Stefan; Andari, Nansi; Andeen, Timothy; Anders, Christoph Falk; Anders, Gabriel; Anderson, Kelby; Andreazza, Attilio; Andrei, George Victor; Anduaga, Xabier; Anger, Philipp; Angerami, Aaron; Anghinolfi, Francis; Anisenkov, Alexey; Anjos, Nuno; Annovi, Alberto; Antonaki, Ariadni; Antonelli, Mario; Antonov, Alexey; Antos, Jaroslav; Anulli, Fabio; Aoki, Masato; Aoun, Sahar; Aperio Bella, Ludovica; Apolle, Rudi; Arabidze, Giorgi; Aracena, Ignacio; Arai, Yasuo; Arce, Ayana; Arfaoui, Samir; Arguin, Jean-Francois; Arik, Engin; Arik, Metin; Armbruster, Aaron James; Arnaez, Olivier; Arnal, Vanessa; Arnault, Christian; Artamonov, Andrei; Artoni, Giacomo; Arutinov, David; Asai, Shoji; Asfandiyarov, Ruslan; Ask, Stefan; Åsman, Barbro; Asquith, Lily; Assamagan, Ketevi; Astbury, Alan; Atkinson, Markus; Aubert, Bernard; Auge, Etienne; Augsten, Kamil; Aurousseau, Mathieu; Avolio, Giuseppe; Avramidou, Rachel Maria; Axen, David; Azuelos, Georges; Azuma, Yuya; Baak, Max; Baccaglioni, Giuseppe; Bacci, Cesare; Bach, Andre; Bachacou, Henri; Bachas, Konstantinos; Backes, Moritz; Backhaus, Malte; Badescu, Elisabeta; Bagnaia, Paolo; Bahinipati, Seema; Bai, Yu; Bailey, David; Bain, Travis; Baines, John; Baker, Oliver Keith; Baker, Mark; Baker, Sarah; Banas, Elzbieta; Banerjee, Piyali; Banerjee, Swagato; Banfi, Danilo; Bangert, Andrea Michelle; Bansal, Vikas; Bansil, Hardeep Singh; Barak, Liron; Baranov, Sergei; Barbaro Galtieri, Angela; Barber, Tom; Barberio, Elisabetta Luigia; Barberis, Dario; Barbero, Marlon; Bardin, Dmitri; Barillari, Teresa; Barisonzi, Marcello; Barklow, Timothy; Barlow, Nick; Barnett, Bruce; Barnett, Michael; Baroncelli, Antonio; Barone, Gaetano; Barr, Alan; Barreiro, Fernando; Barreiro Guimarães da Costa, João; Barrillon, Pierre; Bartoldus, Rainer; Barton, Adam Edward; Bartsch, Valeria; Basye, Austin; Bates, Richard; Batkova, Lucia; Batley, Richard; Battaglia, Andreas; Battistin, Michele; Bauer, Florian; Bawa, Harinder Singh; Beale, Steven; Beau, Tristan; Beauchemin, Pierre-Hugues; Beccherle, Roberto; Bechtle, Philip; Beck, Hans Peter; Becker, Anne Kathrin; Becker, Sebastian; Beckingham, Matthew; Becks, Karl-Heinz; Beddall, Andrew; Beddall, Ayda; Bedikian, Sourpouhi; Bednyakov, Vadim; Bee, Christopher; Beemster, Lars; Begel, Michael; Behar Harpaz, Silvia; Beimforde, Michael; Belanger-Champagne, Camille; Bell, Paul; Bell, William; Bella, Gideon; Bellagamba, Lorenzo; Bellina, Francesco; Bellomo, Massimiliano; Belloni, Alberto; Beloborodova, Olga; Belotskiy, Konstantin; Beltramello, Olga; Benary, Odette; Benchekroun, Driss; Bendtz, Katarina; Benekos, Nektarios; Benhammou, Yan; Benhar Noccioli, Eleonora; Benitez Garcia, Jorge-Armando; Benjamin, Douglas; Benoit, Mathieu; Bensinger, James; Benslama, Kamal; Bentvelsen, Stan; Berge, David; Bergeaas Kuutmann, Elin; Berger, Nicolas; Berghaus, Frank; Berglund, Elina; Beringer, Jürg; Bernat, Pauline; Bernhard, Ralf; Bernius, Catrin; Berry, Tracey; Bertella, Claudia; Bertin, Antonio; Bertolucci, Federico; Besana, Maria Ilaria; Besjes, Geert-Jan; Besson, Nathalie; Bethke, Siegfried; Bhimji, Wahid; Bianchi, Riccardo-Maria; Bianco, Michele; Biebel, Otmar; Bieniek, Stephen Paul; Bierwagen, Katharina; Biesiada, Jed; Biglietti, Michela; Bilokon, Halina; Bindi, Marcello; Binet, Sebastien; Bingul, Ahmet; Bini, Cesare; Biscarat, Catherine; Bittner, Bernhard; Black, Kevin; Blair, Robert; Blanchard, Jean-Baptiste; Blanchot, Georges
2012-01-01
A measurement of $B_s^0 \\to J/\\psi \\phi$ decay parameters, including the CP-violating weak phase $\\phi_s$ and the decay width difference $\\Delta \\Gamma_s$ is reported, using 4.9 fb$^{-1}$ of integrated luminosity collected in 2011 by the ATLAS detector from LHC pp collisions at a centre-of-mass energy $\\sqrt{s}$ = 7 TeV. The mean decay width $\\Gamma_s$ and the transversity amplitudes $|A_0(0)|^2$ and $|A_{||}(0)|^2$ are also measured. The values reported for these parameters are: \\begin{eqnarray}\\cr \\phi_s = 0.22 \\pm 0.41 (stat.) \\pm 0.10 (syst.) rad\\cr \\Delta \\Gamma_s = 0.053 \\pm 0.021 (stat.) \\pm 0.008 (syst.) ps^{-1}\\cr \\Gamma_s = 0.677 \\pm 0.007 (stat.) \\pm 0.004 (syst.) ps^{-1}\\cr |A_0(0)|^2 = 0.528 \\pm 0.006 (stat.) \\pm 0.009 (syst.)\\cr |A_{||}(0)|^2 = 0.220 \\pm 0.008 (stat.) \\pm 0.007 (syst.)\\cr\\end{eqnarray} where the values quoted for $\\phi_s$ and $\\Delta \\Gamma_s$ correspond to the solution compatible with the external measurements to which the strong phase $\\delta$ perpendicular is constrained and ...
Aad, Georges; Abbott, Brad; Abdallah, Jalal; Abdel Khalek, Samah; Abdelalim, Ahmed Ali; Abdinov, Ovsat; Aben, Rosemarie; Abi, Babak; Abolins, Maris; AbouZeid, Ossama; Abramowicz, Halina; Abreu, Henso; Acerbi, Emilio; Acharya, Bobby Samir; Adamczyk, Leszek; Adams, David; Addy, Tetteh; Adelman, Jahred; Adomeit, Stefanie; Adragna, Paolo; Adye, Tim; Aefsky, Scott; Aguilar-Saavedra, Juan Antonio; Agustoni, Marco; Aharrouche, Mohamed; Ahlen, Steven; Ahles, Florian; Ahmad, Ashfaq; Ahsan, Mahsana; Aielli, Giulio; Akdogan, Taylan; Å kesson, Torsten Paul Ake; Akimoto, Ginga; Akimov, Andrei; Alam, Mohammad; Alam, Muhammad Aftab; Albert, Justin; Albrand, Solveig; Aleksa, Martin; Aleksandrov, Igor; Alessandria, Franco; Alexa, Calin; Alexander, Gideon; Alexandre, Gauthier; Alexopoulos, Theodoros; Alhroob, Muhammad; Aliev, Malik; Alimonti, Gianluca; Alison, John; Allbrooke, Benedict; Allport, Phillip; Allwood-Spiers, Sarah; Almond, John; Aloisio, Alberto; Alon, Raz; Alonso, Alejandro; Alonso, Francisco; Alvarez Gonzalez, Barbara; Alviggi, Mariagrazia; Amako, Katsuya; Amelung, Christoph; Ammosov, Vladimir; Amorim, Antonio; Amram, Nir; Anastopoulos, Christos; Ancu, Lucian Stefan; Andari, Nansi; Andeen, Timothy; Anders, Christoph Falk; Anders, Gabriel; Anderson, Kelby; Andreazza, Attilio; Andrei, George Victor; Anduaga, Xabier; Anger, Philipp; Angerami, Aaron; Anghinolfi, Francis; Anisenkov, Alexey; Anjos, Nuno; Annovi, Alberto; Antonaki, Ariadni; Antonelli, Mario; Antonov, Alexey; Antos, Jaroslav; Anulli, Fabio; Aoki, Masato; Aoun, Sahar; Aperio Bella, Ludovica; Apolle, Rudi; Arabidze, Giorgi; Aracena, Ignacio; Arai, Yasuo; Arce, Ayana; Arfaoui, Samir; Arguin, Jean-Francois; Arik, Engin; Arik, Metin; Armbruster, Aaron James; Arnaez, Olivier; Arnal, Vanessa; Arnault, Christian; Artamonov, Andrei; Artoni, Giacomo; Arutinov, David; Asai, Shoji; Asfandiyarov, Ruslan; Ask, Stefan; Å sman, Barbro; Asquith, Lily; Assamagan, Ketevi; Astbury, Alan; Atkinson, Markus; Aubert, Bernard; Auge, Etienne; Augsten, Kamil; Aurousseau, Mathieu; Avolio, Giuseppe; Avramidou, Rachel Maria; Axen, David; Azuelos, Georges; Azuma, Yuya; Baak, Max; Baccaglioni, Giuseppe; Bacci, Cesare; Bach, Andre; Bachacou, Henri; Bachas, Konstantinos; Backes, Moritz; Backhaus, Malte; Badescu, Elisabeta; Bagnaia, Paolo; Bahinipati, Seema; Bai, Yu; Bailey, David; Bain, Travis; Baines, John; Baker, Oliver Keith; Baker, Mark; Baker, Sarah; Banas, Elzbieta; Banerjee, Piyali; Banerjee, Swagato; Banfi, Danilo; Bangert, Andrea Michelle; Bansal, Vikas; Bansil, Hardeep Singh; Barak, Liron; Baranov, Sergei; Barbaro Galtieri, Angela; Barber, Tom; Barberio, Elisabetta Luigia; Barberis, Dario; Barbero, Marlon; Bardin, Dmitri; Barillari, Teresa; Barisonzi, Marcello; Barklow, Timothy; Barlow, Nick; Barnett, Bruce; Barnett, Michael; Baroncelli, Antonio; Barone, Gaetano; Barr, Alan; Barreiro, Fernando; Barreiro Guimarães da Costa, João; Barrillon, Pierre; Bartoldus, Rainer; Barton, Adam Edward; Bartsch, Valeria; Basye, Austin; Bates, Richard; Batkova, Lucia; Batley, Richard; Battaglia, Andreas; Battistin, Michele; Bauer, Florian; Bawa, Harinder Singh; Beale, Steven; Beau, Tristan; Beauchemin, Pierre-Hugues; Beccherle, Roberto; Bechtle, Philip; Beck, Hans Peter; Becker, Anne Kathrin; Becker, Sebastian; Beckingham, Matthew; Becks, Karl-Heinz; Beddall, Andrew; Beddall, Ayda; Bedikian, Sourpouhi; Bednyakov, Vadim; Bee, Christopher; Beemster, Lars; Begel, Michael; Behar Harpaz, Silvia; Beimforde, Michael; Belanger-Champagne, Camille; Bell, Paul; Bell, William; Bella, Gideon; Bellagamba, Lorenzo; Bellina, Francesco; Bellomo, Massimiliano; Belloni, Alberto; Beloborodova, Olga; Belotskiy, Konstantin; Beltramello, Olga; Benary, Odette; Benchekroun, Driss; Bendtz, Katarina; Benekos, Nektarios; Benhammou, Yan; Benhar Noccioli, Eleonora; Benitez Garcia, Jorge-Armando; Benjamin, Douglas; Benoit, Mathieu; Bensinger, James; Benslama, Kamal; Bentvelsen, Stan; Berge, David; Bergeaas Kuutmann, Elin; Berger, Nicolas; Berghaus, Frank; Berglund, Elina; Beringer, Jürg; Bernat, Pauline; Bernhard, Ralf; Bernius, Catrin; Berry, Tracey; Bertella, Claudia; Bertin, Antonio; Bertolucci, Federico; Besana, Maria Ilaria; Besjes, Geert-Jan; Besson, Nathalie; Bethke, Siegfried; Bhimji, Wahid; Bianchi, Riccardo-Maria; Bianco, Michele; Biebel, Otmar; Bieniek, Stephen Paul; Bierwagen, Katharina; Biesiada, Jed; Biglietti, Michela; Bilokon, Halina; Bindi, Marcello; Binet, Sebastien; Bingul, Ahmet; Bini, Cesare; Biscarat, Catherine; Bittner, Bernhard; Black, Kevin; Blair, Robert; Blanchard, Jean-Baptiste; Blanchot, Georges; Blazek, Tomas; Blocker, Craig; Blocki, Jacek; Blondel, Alain; Blum, Walter; Blumenschein, Ulrike; Bobbink, Gerjan; Bobrovnikov, Victor; Bocchetta, Simona Serena; Bocci, Andrea; Boddy, Christopher Richard; Boehler, Michael; Boek, Jennifer; Boelaert, Nele; Bogaerts, Joannes Andreas; Bogdanchikov, Alexander; Bogouch, Andrei; Bohm, Christian; Bohm, Jan; Boisvert, Veronique; Bold, Tomasz; Boldea, Venera; Bolnet, Nayanka Myriam; Bomben, Marco; Bona, Marcella; Boonekamp, Maarten; Booth, Chris; Bordoni, Stefania; Borer, Claudia; Borisov, Anatoly; Borissov, Guennadi; Borjanovic, Iris; Borri, Marcello; Borroni, Sara; Bortolotto, Valerio; Bos, Kors; Boscherini, Davide; Bosman, Martine; Boterenbrood, Hendrik; Bouchami, Jihene; Boudreau, Joseph; Bouhova-Thacker, Evelina Vassileva; Boumediene, Djamel Eddine; Bourdarios, Claire; Bousson, Nicolas; Boveia, Antonio; Boyd, James; Boyko, Igor; Bozovic-Jelisavcic, Ivanka; Bracinik, Juraj; Branchini, Paolo; Brandt, Andrew; Brandt, Gerhard; Brandt, Oleg; Bratzler, Uwe; Brau, Benjamin; Brau, James; Braun, Helmut; Brazzale, Simone Federico; Brelier, Bertrand; Bremer, Johan; Brendlinger, Kurt; Brenner, Richard; Bressler, Shikma; Britton, Dave; Brochu, Frederic; Brock, Ian; Brock, Raymond; Broggi, Francesco; Bromberg, Carl; Bronner, Johanna; Brooijmans, Gustaaf; Brooks, Timothy; Brooks, William; Brown, Gareth; Brown, Heather; Bruckman de Renstrom, Pawel; Bruncko, Dusan; Bruneliere, Renaud; Brunet, Sylvie; Bruni, Alessia; Bruni, Graziano; Bruschi, Marco; Buanes, Trygve; Buat, Quentin; Bucci, Francesca; Buchanan, James; Buchholz, Peter; Buckingham, Ryan; Buckley, Andrew; Buda, Stelian Ioan; Budagov, Ioulian; Budick, Burton; Büscher, Volker; Bugge, Lars; Bulekov, Oleg; Bundock, Aaron Colin; Bunse, Moritz; Buran, Torleiv; Burckhart, Helfried; Burdin, Sergey; Burgess, Thomas; Burke, Stephen; Busato, Emmanuel; Bussey, Peter; Buszello, Claus-Peter; Butler, Bart; Butler, John; Buttar, Craig; Butterworth, Jonathan; Buttinger, William; Byszewski, Marcin; Cabrera Urbán, Susana; Caforio, Davide; Cakir, Orhan; Calafiura, Paolo; Calderini, Giovanni; Calfayan, Philippe; Calkins, Robert; Caloba, Luiz; Caloi, Rita; Calvet, David; Calvet, Samuel; Camacho Toro, Reina; Camarri, Paolo; Cameron, David; Caminada, Lea Michaela; Caminal Armadans, Roger; Campana, Simone; Campanelli, Mario; Canale, Vincenzo; Canelli, Florencia; Canepa, Anadi; Cantero, Josu; Cantrill, Robert; Capasso, Luciano; Capeans Garrido, Maria Del Mar; Caprini, Irinel; Caprini, Mihai; Capriotti, Daniele; Capua, Marcella; Caputo, Regina; Cardarelli, Roberto; Carli, Tancredi; Carlino, Gianpaolo; Carminati, Leonardo; Caron, Bryan; Caron, Sascha; Carquin, Edson; Carrillo Montoya, German D; Carter, Antony; Carter, Janet; Carvalho, João; Casadei, Diego; Casado, Maria Pilar; Cascella, Michele; Caso, Carlo; Castaneda Hernandez, Alfredo Martin; Castaneda-Miranda, Elizabeth; Castillo Gimenez, Victoria; Castro, Nuno Filipe; Cataldi, Gabriella; Catastini, Pierluigi; Catinaccio, Andrea; Catmore, James; Cattai, Ariella; Cattani, Giordano; Caughron, Seth; Cavaliere, Viviana; Cavalleri, Pietro; Cavalli, Donatella; Cavalli-Sforza, Matteo; Cavasinni, Vincenzo; Ceradini, Filippo; Cerqueira, Augusto Santiago; Cerri, Alessandro; Cerrito, Lucio; Cerutti, Fabio; Cetin, Serkant Ali; Chafaq, Aziz; Chakraborty, Dhiman; Chalupkova, Ina; Chan, Kevin; Chang, Philip; Chapleau, Bertrand; Chapman, John Derek; Chapman, John Wehrley; Chareyre, Eve; Charlton, Dave; Chavda, Vikash; Chavez Barajas, Carlos Alberto; Cheatham, Susan; Chekanov, Sergei; Chekulaev, Sergey; Chelkov, Gueorgui; Chelstowska, Magda Anna; Chen, Chunhui; Chen, Hucheng; Chen, Shenjian; Chen, Xin; Chen, Yujiao; Cheplakov, Alexander; Cherkaoui El Moursli, Rajaa; Chernyatin, Valeriy; Cheu, Elliott; Cheung, Sing-Leung; Chevalier, Laurent; Chiefari, Giovanni; Chikovani, Leila; Childers, John Taylor; Chilingarov, Alexandre; Chiodini, Gabriele; Chisholm, Andrew; Chislett, Rebecca Thalatta; Chitan, Adrian; Chizhov, Mihail; Choudalakis, Georgios; Chouridou, Sofia; Christidi, Illectra-Athanasia; Christov, Asen; Chromek-Burckhart, Doris; Chu, Ming-Lee; Chudoba, Jiri; Ciapetti, Guido; Ciftci, Abbas Kenan; Ciftci, Rena; Cinca, Diane; Cindro, Vladimir; Ciocca, Claudia; Ciocio, Alessandra; Cirilli, Manuela; Cirkovic, Predrag; Citterio, Mauro; Ciubancan, Mihai; Clark, Allan G; Clark, Philip James; Clarke, Robert; Cleland, Bill; Clemens, Jean-Claude; Clement, Benoit; Clement, Christophe; Coadou, Yann; Cobal, Marina; Coccaro, Andrea; Cochran, James H; Cogan, Joshua Godfrey; Coggeshall, James; Cogneras, Eric; Colas, Jacques; Cole, Stephen; Colijn, Auke-Pieter; Collins, Neil; Collins-Tooth, Christopher; Collot, Johann; Colombo, Tommaso; Colon, German; Conde Muiño, Patricia; Coniavitis, Elias; Conidi, Maria Chiara; Consonni, Sofia Maria; Consorti, Valerio; Constantinescu, Serban; Conta, Claudio; Conti, Geraldine; Conventi, Francesco; Cooke, Mark; Cooper, Ben; Cooper-Sarkar, Amanda; Copic, Katherine; Cornelissen, Thijs; Corradi, Massimo; Corriveau, Francois; Cortes-Gonzalez, Arely; Cortiana, Giorgio; Costa, Giuseppe; Costa, María José; Costanzo, Davide; Côté, David; Courneyea, Lorraine; Cowan, Glen; Cowden, Christopher; Cox, Brian; Cranmer, Kyle; Crescioli, Francesco; Cristinziani, Markus; Crosetti, Giovanni; Crépé-Renaudin, Sabine; Cuciuc, Constantin-Mihai; Cuenca Almenar, Cristóbal; Cuhadar Donszelmann, Tulay; Curatolo, Maria; Curtis, Chris; Cuthbert, Cameron; Cwetanski, Peter; Czirr, Hendrik; Czodrowski, Patrick; Czyczula, Zofia; D'Auria, Saverio; D'Onofrio, Monica; D'Orazio, Alessia; Da Cunha Sargedas De Sousa, Mario Jose; Da Via, Cinzia; Dabrowski, Wladyslaw; Dafinca, Alexandru; Dai, Tiesheng; Dallapiccola, Carlo; Dam, Mogens; Dameri, Mauro; Damiani, Daniel; Danielsson, Hans Olof; Dao, Valerio; Darbo, Giovanni; Darlea, Georgiana Lavinia; Dassoulas, James; Davey, Will; Davidek, Tomas; Davidson, Nadia; Davidson, Ruth; Davies, Eleanor; Davies, Merlin; Davignon, Olivier; Davison, Adam; Davygora, Yuriy; Dawe, Edmund; Dawson, Ian; Daya-Ishmukhametova, Rozmin; De, Kaushik; de Asmundis, Riccardo; De Castro, Stefano; De Cecco, Sandro; de Graat, Julien; De Groot, Nicolo; de Jong, Paul; De La Taille, Christophe; De la Torre, Hector; De Lorenzi, Francesco; de Mora, Lee; De Nooij, Lucie; De Pedis, Daniele; De Salvo, Alessandro; De Sanctis, Umberto; De Santo, Antonella; De Vivie De Regie, Jean-Baptiste; De Zorzi, Guido; Dearnaley, William James; Debbe, Ramiro; Debenedetti, Chiara; Dechenaux, Benjamin; Dedovich, Dmitri; Degenhardt, James; Del Papa, Carlo; Del Peso, Jose; Del Prete, Tarcisio; Delemontex, Thomas; Deliyergiyev, Maksym; Dell'Acqua, Andrea; Dell'Asta, Lidia; Della Pietra, Massimo; della Volpe, Domenico; Delmastro, Marco; Delsart, Pierre-Antoine; Deluca, Carolina; Demers, Sarah; Demichev, Mikhail; Demirkoz, Bilge; Deng, Jianrong; Denisov, Sergey; Derendarz, Dominik; Derkaoui, Jamal Eddine; Derue, Frederic; Dervan, Paul; Desch, Klaus Kurt; Devetak, Erik; Deviveiros, Pier-Olivier; Dewhurst, Alastair; DeWilde, Burton; Dhaliwal, Saminder; Dhullipudi, Ramasudhakar; Di Ciaccio, Anna; Di Ciaccio, Lucia; Di Girolamo, Alessandro; Di Girolamo, Beniamino; Di Luise, Silvestro; Di Mattia, Alessandro; Di Micco, Biagio; Di Nardo, Roberto; Di Simone, Andrea; Di Sipio, Riccardo; Diaz, Marco Aurelio; Diehl, Edward; Dietrich, Janet; Dietzsch, Thorsten; Diglio, Sara; Dindar Yagci, Kamile; Dingfelder, Jochen; Dinut, Florin; Dionisi, Carlo; Dita, Petre; Dita, Sanda; Dittus, Fridolin; Djama, Fares; Djobava, Tamar; do Vale, Maria Aline Barros; Do Valle Wemans, André; Doan, Thi Kieu Oanh; Dobbs, Matt; Dobinson, Robert; Dobos, Daniel; Dobson, Ellie; Dodd, Jeremy; Doglioni, Caterina; Doherty, Tom; Doi, Yoshikuni; Dolejsi, Jiri; Dolenc, Irena; Dolezal, Zdenek; Dolgoshein, Boris; Dohmae, Takeshi; Donadelli, Marisilvia; Donini, Julien; Dopke, Jens; Doria, Alessandra; Dos Anjos, Andre; Dotti, Andrea; Dova, Maria-Teresa; Doxiadis, Alexander; Doyle, Tony; Dris, Manolis; Dubbert, Jörg; Dube, Sourabh; Duchovni, Ehud; Duckeck, Guenter; Duda, Dominik; Dudarev, Alexey; Dudziak, Fanny; Dührssen, Michael; Duerdoth, Ian; Duflot, Laurent; Dufour, Marc-Andre; Duguid, Liam; Dunford, Monica; Duran Yildiz, Hatice; Duxfield, Robert; Dwuznik, Michal; Dydak, Friedrich; Düren, Michael; Ebke, Johannes; Eckweiler, Sebastian; Edmonds, Keith; Edson, William; Edwards, Clive; Edwards, Nicholas Charles; Ehrenfeld, Wolfgang; Eifert, Till; Eigen, Gerald; Einsweiler, Kevin; Eisenhandler, Eric; Ekelof, Tord; El Kacimi, Mohamed; Ellert, Mattias; Elles, Sabine; Ellinghaus, Frank; Ellis, Katherine; Ellis, Nicolas; Elmsheuser, Johannes; Elsing, Markus; Emeliyanov, Dmitry; Engelmann, Roderich; Engl, Albert; Epp, Brigitte; Erdmann, Johannes; Ereditato, Antonio; Eriksson, Daniel; Ernst, Jesse; Ernst, Michael; Ernwein, Jean; Errede, Deborah; Errede, Steven; Ertel, Eugen; Escalier, Marc; Esch, Hendrik; Escobar, Carlos; Espinal Curull, Xavier; Esposito, Bellisario; Etienne, Francois; Etienvre, Anne-Isabelle; Etzion, Erez; Evangelakou, Despoina; Evans, Hal; Fabbri, Laura; Fabre, Caroline; Fakhrutdinov, Rinat; Falciano, Speranza; Fang, Yaquan; Fanti, Marcello; Farbin, Amir; Farilla, Addolorata; Farley, Jason; Farooque, Trisha; Farrell, Steven; Farrington, Sinead; Farthouat, Philippe; Fassi, Farida; Fassnacht, Patrick; Fassouliotis, Dimitrios; Fatholahzadeh, Baharak; Favareto, Andrea; Fayard, Louis; Fazio, Salvatore; Febbraro, Renato; Federic, Pavol; Fedin, Oleg; Fedorko, Wojciech; Fehling-Kaschek, Mirjam; Feligioni, Lorenzo; Fellmann, Denis; Feng, Cunfeng; Feng, Eric; Fenyuk, Alexander; Ferencei, Jozef; Fernando, Waruna; Ferrag, Samir; Ferrando, James; Ferrara, Valentina; Ferrari, Arnaud; Ferrari, Pamela; Ferrari, Roberto; Ferreira de Lima, Danilo Enoque; Ferrer, Antonio; Ferrere, Didier; Ferretti, Claudio; Ferretto Parodi, Andrea; Fiascaris, Maria; Fiedler, Frank; Filipčič, Andrej; Filthaut, Frank; Fincke-Keeler, Margret; Fiolhais, Miguel; Fiorini, Luca; Firan, Ana; Fischer, Gordon; Fisher, Matthew; Flechl, Martin; Fleck, Ivor; Fleckner, Johanna; Fleischmann, Philipp; Fleischmann, Sebastian; Flick, Tobias; Floderus, Anders; Flores Castillo, Luis; Flowerdew, Michael; Fonseca Martin, Teresa; Formica, Andrea; Forti, Alessandra; Fortin, Dominique; Fournier, Daniel; Fox, Harald; Francavilla, Paolo; Franchini, Matteo; Franchino, Silvia; Francis, David; Frank, Tal; Franz, Sebastien; Fraternali, Marco; Fratina, Sasa; French, Sky; Friedrich, Conrad; Friedrich, Felix; Froeschl, Robert; Froidevaux, Daniel; Frost, James; Fukunaga, Chikara; Fullana Torregrosa, Esteban; Fulsom, Bryan Gregory; Fuster, Juan; Gabaldon, Carolina; Gabizon, Ofir; Gadfort, Thomas; Gadomski, Szymon; Gagliardi, Guido; Gagnon, Pauline; Galea, Cristina; Gallas, Elizabeth; Gallo, Valentina Santina; Gallop, Bruce; Gallus, Petr; Gan, KK; Gao, Yongsheng; Gaponenko, Andrei; Garberson, Ford; Garcia-Sciveres, Maurice; García, Carmen; García Navarro, José Enrique; Gardner, Robert; Garelli, Nicoletta; Garitaonandia, Hegoi; Garonne, Vincent; Gatti, Claudio; Gaudio, Gabriella; Gaur, Bakul; Gauthier, Lea; Gauzzi, Paolo; Gavrilenko, Igor; Gay, Colin; Gaycken, Goetz; Gazis, Evangelos; Ge, Peng; Gecse, Zoltan; Gee, Norman; Geerts, Daniël Alphonsus Adrianus; Geich-Gimbel, Christoph; Gellerstedt, Karl; Gemme, Claudia; Gemmell, Alistair; Genest, Marie-Hélène; Gentile, Simonetta; George, Matthias; George, Simon; Gerlach, Peter; Gershon, Avi; Geweniger, Christoph; Ghazlane, Hamid; Ghodbane, Nabil; Giacobbe, Benedetto; Giagu, Stefano; Giakoumopoulou, Victoria; Giangiobbe, Vincent; Gianotti, Fabiola; Gibbard, Bruce; Gibson, Adam; Gibson, Stephen; Gillberg, Dag; Gillman, Tony; Gingrich, Douglas; Ginzburg, Jonatan; Giokaris, Nikos; Giordani, MarioPaolo; Giordano, Raffaele; Giorgi, Francesco Michelangelo; Giovannini, Paola; Giraud, Pierre-Francois; Giugni, Danilo; Giunta, Michele; Giusti, Paolo; Gjelsten, Bø rge Kile; Gladilin, Leonid; Glasman, Claudia; Glatzer, Julian; Glazov, Alexandre; Glitza, Karl-Walter; Glonti, George; Goddard, Jack Robert; Godfrey, Jennifer; Godlewski, Jan; Goebel, Martin; Göpfert, Thomas; Goeringer, Christian; Gössling, Claus; Goldfarb, Steven; Golling, Tobias; Gomes, Agostinho; Gomez Fajardo, Luz Stella; Gonçalo, Ricardo; Goncalves Pinto Firmino Da Costa, Joao; Gonella, Laura; Gonzalez, Saul; González de la Hoz, Santiago; Gonzalez Parra, Garoe; Gonzalez Silva, Laura; Gonzalez-Sevilla, Sergio; Goodson, Jeremiah Jet; Goossens, Luc; Gorbounov, Petr Andreevich; Gordon, Howard; Gorelov, Igor; Gorfine, Grant; Gorini, Benedetto; Gorini, Edoardo; Gorišek, Andrej; Gornicki, Edward; Gosdzik, Bjoern; Goshaw, Alfred; Gosselink, Martijn; Gostkin, Mikhail Ivanovitch; Gough Eschrich, Ivo; Gouighri, Mohamed; Goujdami, Driss; Goulette, Marc Phillippe; Goussiou, Anna; Goy, Corinne; Gozpinar, Serdar; Grabowska-Bold, Iwona; Grafström, Per; Grahn, Karl-Johan; Grancagnolo, Francesco; Grancagnolo, Sergio; Grassi, Valerio; Gratchev, Vadim; Grau, Nathan; Gray, Heather; Gray, Julia Ann; Graziani, Enrico; Grebenyuk, Oleg; Greenshaw, Timothy; Greenwood, Zeno Dixon; Gregersen, Kristian; Gregor, Ingrid-Maria; Grenier, Philippe; Griffiths, Justin; Grigalashvili, Nugzar; Grillo, Alexander; Grinstein, Sebastian; Gris, Philippe Luc Yves; Grishkevich, Yaroslav; Grivaz, Jean-Francois; Gross, Eilam; Grosse-Knetter, Joern; Groth-Jensen, Jacob; Grybel, Kai; Guest, Daniel; Guicheney, Christophe; Guindon, Stefan; Gul, Umar; Guler, Hulya; Gunther, Jaroslav; Guo, Bin; Guo, Jun; Gutierrez, Phillip; Guttman, Nir; Gutzwiller, Olivier; Guyot, Claude; Gwenlan, Claire; Gwilliam, Carl; Haas, Andy; Haas, Stefan; Haber, Carl; Hadavand, Haleh Khani; Hadley, David; Haefner, Petra; Hahn, Ferdinand; Haider, Stefan; Hajduk, Zbigniew; Hakobyan, Hrachya; Hall, David; Haller, Johannes; Hamacher, Klaus; Hamal, Petr; Hamer, Matthias; Hamilton, Andrew; Hamilton, Samuel; Han, Liang; Hanagaki, Kazunori; Hanawa, Keita; Hance, Michael; Handel, Carsten; Hanke, Paul; Hansen, John Renner; Hansen, Jø rgen Beck; Hansen, Jorn Dines; Hansen, Peter Henrik; Hansson, Per; Hara, Kazuhiko; Hare, Gabriel; Harenberg, Torsten; Harkusha, Siarhei; Harper, Devin; Harrington, Robert; Harris, Orin; Hartert, Jochen; Hartjes, Fred; Haruyama, Tomiyoshi; Harvey, Alex; Hasegawa, Satoshi; Hasegawa, Yoji; Hassani, Samira; Haug, Sigve; Hauschild, Michael; Hauser, Reiner; Havranek, Miroslav; Hawkes, Christopher; Hawkings, Richard John; Hawkins, Anthony David; Hawkins, Donovan; Hayakawa, Takashi; Hayashi, Takayasu; Hayden, Daniel; Hays, Chris; Hayward, Helen; Haywood, Stephen; He, Mao; Head, Simon; Hedberg, Vincent; Heelan, Louise; Heim, Sarah; Heinemann, Beate; Heisterkamp, Simon; Helary, Louis; Heller, Claudio; Heller, Matthieu; Hellman, Sten; Hellmich, Dennis; Helsens, Clement; Henderson, Robert; Henke, Michael; Henrichs, Anna; Henriques Correia, Ana Maria; Henrot-Versille, Sophie; Hensel, Carsten; Henß, Tobias; Hernandez, Carlos Medina; Hernández Jiménez, Yesenia; Herrberg, Ruth; Herten, Gregor; Hertenberger, Ralf; Hervas, Luis; Hesketh, Gavin Grant; Hessey, Nigel; Higón-Rodriguez, Emilio; Hill, John; Hiller, Karl Heinz; Hillert, Sonja; Hillier, Stephen; Hinchliffe, Ian; Hines, Elizabeth; Hirose, Minoru; Hirsch, Florian; Hirschbuehl, Dominic; Hobbs, John; Hod, Noam; Hodgkinson, Mark; Hodgson, Paul; Hoecker, Andreas; Hoeferkamp, Martin; Hoffman, Julia; Hoffmann, Dirk; Hohlfeld, Marc; Holder, Martin; Holmgren, Sven-Olof; Holy, Tomas; Holzbauer, Jenny; Hong, Tae Min; Hooft van Huysduynen, Loek; Horner, Stephan; Hostachy, Jean-Yves; Hou, Suen; Hoummada, Abdeslam; Howard, Jacob; Howarth, James; Hristova, Ivana; Hrivnac, Julius; Hryn'ova, Tetiana; Hsu, Pai-hsien Jennifer; Hsu, Shih-Chieh; Hu, Diedi; Hubacek, Zdenek; Hubaut, Fabrice; Huegging, Fabian; Huettmann, Antje; Huffman, Todd Brian; Hughes, Emlyn; Hughes, Gareth; Huhtinen, Mika; Hurwitz, Martina; Husemann, Ulrich; Huseynov, Nazim; Huston, Joey; Huth, John; Iacobucci, Giuseppe; Iakovidis, Georgios; Ibbotson, Michael; Ibragimov, Iskander; Iconomidou-Fayard, Lydia; Idarraga, John; Iengo, Paolo; Igonkina, Olga; Ikegami, Yoichi; Ikeno, Masahiro; Iliadis, Dimitrios; Ilic, Nikolina; Ince, Tayfun; Inigo-Golfin, Joaquin; Ioannou, Pavlos; Iodice, Mauro; Iordanidou, Kalliopi; Ippolito, Valerio; Irles Quiles, Adrian; Isaksson, Charlie; Ishino, Masaya; Ishitsuka, Masaki; Ishmukhametov, Renat; Issever, Cigdem; Istin, Serhat; Ivashin, Anton; Iwanski, Wieslaw; Iwasaki, Hiroyuki; Izen, Joseph; Izzo, Vincenzo; Jackson, Brett; Jackson, John; Jackson, Paul; Jaekel, Martin; Jain, Vivek; Jakobs, Karl; Jakobsen, Sune; Jakoubek, Tomas; Jakubek, Jan; Jana, Dilip; Jansen, Eric; Jansen, Hendrik; Jantsch, Andreas; Janus, Michel; Jarlskog, Göran; Jeanty, Laura; Jen-La Plante, Imai; Jennens, David; Jenni, Peter; Loevschall-Jensen, Ask Emil; Jež, Pavel; Jézéquel, Stéphane; Jha, Manoj Kumar; Ji, Haoshuang; Ji, Weina; Jia, Jiangyong; Jiang, Yi; Jimenez Belenguer, Marcos; Jin, Shan; Jinnouchi, Osamu; Joergensen, Morten Dam; Joffe, David; Johansen, Marianne; Johansson, Erik; Johansson, Per; Johnert, Sebastian; Johns, Kenneth; Jon-And, Kerstin; Jones, Graham; Jones, Roger; Jones, Tim; Joram, Christian; Jorge, Pedro; Joshi, Kiran Daniel; Jovicevic, Jelena; Jovin, Tatjana; Ju, Xiangyang; Jung, Christian; Jungst, Ralph Markus; Juranek, Vojtech; Jussel, Patrick; Juste Rozas, Aurelio; Kabana, Sonja; Kaci, Mohammed; Kaczmarska, Anna; Kadlecik, Peter; Kado, Marumi; Kagan, Harris; Kagan, Michael; Kajomovitz, Enrique; Kalinin, Sergey; Kalinovskaya, Lidia; Kama, Sami; Kanaya, Naoko; Kaneda, Michiru; Kaneti, Steven; Kanno, Takayuki; Kantserov, Vadim; Kanzaki, Junichi; Kaplan, Benjamin; Kapliy, Anton; Kaplon, Jan; Kar, Deepak; Karagounis, Michael; Karakostas, Konstantinos; Karnevskiy, Mikhail; Kartvelishvili, Vakhtang; Karyukhin, Andrey; Kashif, Lashkar; Kasieczka, Gregor; Kass, Richard; Kastanas, Alex; Kataoka, Mayuko; Kataoka, Yousuke; Katsoufis, Elias; Katzy, Judith; Kaushik, Venkatesh; Kawagoe, Kiyotomo; Kawamoto, Tatsuo; Kawamura, Gen; Kayl, Manuel; Kazama, Shingo; Kazanin, Vassili; Kazarinov, Makhail; Keeler, Richard; Kehoe, Robert; Keil, Markus; Kekelidze, George; Keller, John; Kenyon, Mike; Kepka, Oldrich; Kerschen, Nicolas; Kerševan, Borut Paul; Kersten, Susanne; Kessoku, Kohei; Keung, Justin; Khalil-zada, Farkhad; Khandanyan, Hovhannes; Khanov, Alexander; Kharchenko, Dmitri; Khodinov, Alexander; Khomich, Andrei; Khoo, Teng Jian; Khoriauli, Gia; Khoroshilov, Andrey; Khovanskiy, Valery; Khramov, Evgeniy; Khubua, Jemal; Kim, Hyeon Jin; Kim, Shinhong; Kimura, Naoki; Kind, Oliver; King, Barry; King, Matthew; King, Robert Steven Beaufoy; Kirk, Julie; Kiryunin, Andrey; Kishimoto, Tomoe; Kisielewska, Danuta; Kitamura, Takumi; Kittelmann, Thomas; Kiuchi, Kenji; Kladiva, Eduard; Klein, Max; Klein, Uta; Kleinknecht, Konrad; Klemetti, Miika; Klier, Amit; Klimek, Pawel; Klimentov, Alexei; Klingenberg, Reiner; Klinger, Joel Alexander; Klinkby, Esben; Klioutchnikova, Tatiana; Klok, Peter; Klous, Sander; Kluge, Eike-Erik; Kluge, Thomas; Kluit, Peter; Kluth, Stefan; Knecht, Neil; Kneringer, Emmerich; Knoops, Edith; Knue, Andrea; Ko, Byeong Rok; Kobayashi, Tomio; Kobel, Michael; Kocian, Martin; Kodys, Peter; Köneke, Karsten; König, Adriaan; Koenig, Sebastian; Köpke, Lutz; Koetsveld, Folkert; Koevesarki, Peter; Koffas, Thomas; Koffeman, Els; Kogan, Lucy Anne; Kohlmann, Simon; Kohn, Fabian; Kohout, Zdenek; Kohriki, Takashi; Koi, Tatsumi; Kolachev, Guennady; Kolanoski, Hermann; Kolesnikov, Vladimir; Koletsou, Iro; Koll, James; Kollefrath, Michael; Komar, Aston; Komori, Yuto; Kondo, Takahiko; Kono, Takanori; Kononov, Anatoly; Konoplich, Rostislav; Konstantinidis, Nikolaos; Koperny, Stefan; Korcyl, Krzysztof; Kordas, Kostantinos; Korn, Andreas; Korol, Aleksandr; Korolkov, Ilya; Korolkova, Elena; Korotkov, Vladislav; Kortner, Oliver; Kortner, Sandra; Kostyukhin, Vadim; Kotov, Sergey; Kotov, Vladislav; Kotwal, Ashutosh; Kourkoumelis, Christine; Kouskoura, Vasiliki; Koutsman, Alex; Kowalewski, Robert Victor; Kowalski, Tadeusz; Kozanecki, Witold; Kozhin, Anatoly; Kral, Vlastimil; Kramarenko, Viktor; Kramberger, Gregor; Krasny, Mieczyslaw Witold; Krasznahorkay, Attila; Kraus, Jana; Kreiss, Sven; Krejci, Frantisek; Kretzschmar, Jan; Krieger, Nina; Krieger, Peter; Kroeninger, Kevin; Kroha, Hubert; Kroll, Joe; Kroseberg, Juergen; Krstic, Jelena; Kruchonak, Uladzimir; Krüger, Hans; Kruker, Tobias; Krumnack, Nils; Krumshteyn, Zinovii; Kubota, Takashi; Kuday, Sinan; Kuehn, Susanne; Kugel, Andreas; Kuhl, Thorsten; Kuhn, Dietmar; Kukhtin, Victor; Kulchitsky, Yuri; Kuleshov, Sergey; Kummer, Christian; Kuna, Marine; Kunkle, Joshua; Kupco, Alexander; Kurashige, Hisaya; Kurata, Masakazu; Kurochkin, Yurii; Kus, Vlastimil; Kuwertz, Emma Sian; Kuze, Masahiro; Kvita, Jiri; Kwee, Regina; La Rosa, Alessandro; La Rotonda, Laura; Labarga, Luis; Labbe, Julien; Lablak, Said; Lacasta, Carlos; Lacava, Francesco; Lacker, Heiko; Lacour, Didier; Lacuesta, Vicente Ramón; Ladygin, Evgueni; Lafaye, Remi; Laforge, Bertrand; Lagouri, Theodota; Lai, Stanley; Laisne, Emmanuel; Lamanna, Massimo; Lambourne, Luke; Lampen, Caleb; Lampl, Walter; Lancon, Eric; Landgraf, Ulrich; Landon, Murrough; Lane, Jenna; Lang, Valerie Susanne; Lange, Clemens; Lankford, Andrew; Lanni, Francesco; Lantzsch, Kerstin; Laplace, Sandrine; Lapoire, Cecile; Laporte, Jean-Francois; Lari, Tommaso; Larner, Aimee; Lassnig, Mario; Laurelli, Paolo; Lavorini, Vincenzo; Lavrijsen, Wim; Laycock, Paul; Le Dortz, Olivier; Le Guirriec, Emmanuel; Le Maner, Christophe; Le Menedeu, Eve; LeCompte, Thomas; Ledroit-Guillon, Fabienne Agnes Marie; Lee, Hurng-Chun; Lee, Jason; Lee, Shih-Chang; Lee, Lawrence; Lefebvre, Michel; Legendre, Marie; Legger, Federica; Leggett, Charles; Lehmacher, Marc; Lehmann Miotto, Giovanna; Lei, Xiaowen; Leite, Marco Aurelio Lisboa; Leitner, Rupert; Lellouch, Daniel; Lemmer, Boris; Lendermann, Victor; Leney, Katharine; Lenz, Tatiana; Lenzen, Georg; Lenzi, Bruno; Leonhardt, Kathrin; Leontsinis, Stefanos; Lepold, Florian; Leroy, Claude; Lessard, Jean-Raphael; Lester, Christopher; Lester, Christopher Michael; Levêque, Jessica; Levin, Daniel; Levinson, Lorne; Lewis, Adrian; Lewis, George; Leyko, Agnieszka; Leyton, Michael; Li, Bo; Li, Haifeng; Li, Shu; Li, Xuefei; Liang, Zhijun; Liao, Hongbo; Liberti, Barbara; Lichard, Peter; Lichtnecker, Markus; Lie, Ki; Liebig, Wolfgang; Limbach, Christian; Limosani, Antonio; Limper, Maaike; Lin, Simon; Linde, Frank; Linnemann, James; Lipeles, Elliot; Lipniacka, Anna; Liss, Tony; Lissauer, David; Lister, Alison; Litke, Alan; Liu, Chuanlei; Liu, Dong; Liu, Hao; Liu, Jianbei; Liu, Lulu; Liu, Minghui; Liu, Yanwen; Livan, Michele; Livermore, Sarah; Lleres, Annick; Llorente Merino, Javier; Lloyd, Stephen; Lobodzinska, Ewelina; Loch, Peter; Lockman, William; Loddenkoetter, Thomas; Loebinger, Fred; Loginov, Andrey; Loh, Chang Wei; Lohse, Thomas; Lohwasser, Kristin; Lokajicek, Milos; Lombardo, Vincenzo Paolo; Long, Robin Eamonn; Lopes, Lourenco; Lopez Mateos, David; Lorenz, Jeanette; Lorenzo Martinez, Narei; Losada, Marta; Loscutoff, Peter; Lo Sterzo, Francesco; Losty, Michael; Lou, Xinchou; Lounis, Abdenour; Loureiro, Karina; Love, Jeremy; Love, Peter; Lowe, Andrew; Lu, Feng; Lubatti, Henry; Luci, Claudio; Lucotte, Arnaud; Ludwig, Andreas; Ludwig, Dörthe; Ludwig, Inga; Ludwig, Jens; Luehring, Frederick; Luijckx, Guy; Lukas, Wolfgang; Lumb, Debra; Luminari, Lamberto; Lund, Esben; Lund-Jensen, Bengt; Lundberg, Björn; Lundberg, Johan; Lundberg, Olof; Lundquist, Johan; Lungwitz, Matthias; Lynn, David; Lytken, Else; Ma, Hong; Ma, Lian Liang; Maccarrone, Giovanni; Macchiolo, Anna; Maček, Boštjan; Machado Miguens, Joana; Mackeprang, Rasmus; Madaras, Ronald; Maddocks, Harvey Jonathan; Mader, Wolfgang; Maenner, Reinhard; Maeno, Tadashi; Mättig, Peter; Mättig, Stefan; Magnoni, Luca; Magradze, Erekle; Mahboubi, Kambiz; Mahmoud, Sara; Mahout, Gilles; Maiani, Camilla; Maidantchik, Carmen; Maio, Amélia; Majewski, Stephanie; Makida, Yasuhiro; Makovec, Nikola; Mal, Prolay; Malaescu, Bogdan; Malecki, Pawel; Malecki, Piotr; Maleev, Victor; Malek, Fairouz; Mallik, Usha; Malon, David; Malone, Caitlin; Maltezos, Stavros; Malyshev, Vladimir; Malyukov, Sergei; Mameghani, Raphael; Mamuzic, Judita; Manabe, Atsushi; Mandelli, Luciano; Mandić, Igor; Mandrysch, Rocco; Maneira, José; Manfredini, Alessandro; Mangeard, Pierre-Simon; Manhaes de Andrade Filho, Luciano; Manjarres Ramos, Joany Andreina; Mann, Alexander; Manning, Peter; Manousakis-Katsikakis, Arkadios; Mansoulie, Bruno; Mapelli, Alessandro; Mapelli, Livio; March, Luis; Marchand, Jean-Francois; Marchese, Fabrizio; Marchiori, Giovanni; Marcisovsky, Michal; Marino, Christopher; Marroquim, Fernando; Marshall, Zach; Martens, Kalen; Marti, Lukas Fritz; Marti-Garcia, Salvador; Martin, Brian; Martin, Brian; Martin, Jean-Pierre; Martin, Tim; Martin, Victoria Jane; Martin dit Latour, Bertrand; Martin-Haugh, Stewart; Martinez, Mario; Martinez Outschoorn, Verena; Martyniuk, Alex; Marx, Marilyn; Marzano, Francesco; Marzin, Antoine; Masetti, Lucia; Mashimo, Tetsuro; Mashinistov, Ruslan; Masik, Jiri; Maslennikov, Alexey; Massa, Ignazio; Massaro, Graziano; Massol, Nicolas; Mastrandrea, Paolo; Mastroberardino, Anna; Masubuchi, Tatsuya; Matricon, Pierre; Matsunaga, Hiroyuki; Matsushita, Takashi; Mattravers, Carly; Maurer, Julien; Maxfield, Stephen; Mayne, Anna; Mazini, Rachid; Mazur, Michael; Mazzaferro, Luca; Mazzanti, Marcello; Mc Donald, Jeffrey; Mc Kee, Shawn Patrick; McCarn, Allison; McCarthy, Robert; McCarthy, Tom; McCubbin, Norman; McFarlane, Kenneth; Mcfayden, Josh; Mchedlidze, Gvantsa; Mclaughlan, Tom; McMahon, Steve; McPherson, Robert; Meade, Andrew; Mechnich, Joerg; Mechtel, Markus; Medinnis, Mike; Meera-Lebbai, Razzak; Meguro, Tatsuma; Mehdiyev, Rashid; Mehlhase, Sascha; Mehta, Andrew; Meier, Karlheinz; Meirose, Bernhard; Melachrinos, Constantinos; Mellado Garcia, Bruce Rafael; Meloni, Federico; Mendoza Navas, Luis; Meng, Zhaoxia; Mengarelli, Alberto; Menke, Sven; Meoni, Evelin; Mercurio, Kevin Michael; Mermod, Philippe; Merola, Leonardo; Meroni, Chiara; Merritt, Frank; Merritt, Hayes; Messina, Andrea; Metcalfe, Jessica; Mete, Alaettin Serhan; Meyer, Carsten; Meyer, Christopher; Meyer, Jean-Pierre; Meyer, Jochen; Meyer, Joerg; Meyer, Thomas Christian; Miao, Jiayuan; Michal, Sebastien; Micu, Liliana; Middleton, Robin; Migas, Sylwia; Mijović, Liza; Mikenberg, Giora; Mikestikova, Marcela; Mikuž, Marko; Miller, David; Miller, Robert; Mills, Bill; Mills, Corrinne; Milov, Alexander; Milstead, David; Milstein, Dmitry; Minaenko, Andrey; Miñano Moya, Mercedes; Minashvili, Irakli; Mincer, Allen; Mindur, Bartosz; Mineev, Mikhail; Ming, Yao; Mir, Lluisa-Maria; Mirabelli, Giovanni; Mitrevski, Jovan; Mitsou, Vasiliki A; Mitsui, Shingo; Miyagawa, Paul; Mjörnmark, Jan-Ulf; Moa, Torbjoern; Moeller, Victoria; Mönig, Klaus; Möser, Nicolas; Mohapatra, Soumya; Mohr, Wolfgang; Moles-Valls, Regina; Monk, James; Monnier, Emmanuel; Montejo Berlingen, Javier; Monticelli, Fernando; Monzani, Simone; Moore, Roger; Moorhead, Gareth; Mora Herrera, Clemencia; Moraes, Arthur; Morange, Nicolas; Morel, Julien; Morello, Gianfranco; Moreno, Deywis; Moreno Llácer, María; Morettini, Paolo; Morgenstern, Marcus; Morii, Masahiro; Morley, Anthony Keith; Mornacchi, Giuseppe; Morris, John; Morvaj, Ljiljana; Moser, Hans-Guenther; Mosidze, Maia; Moss, Josh; Mount, Richard; Mountricha, Eleni; Mouraviev, Sergei; Moyse, Edward; Mueller, Felix; Mueller, James; Mueller, Klemens; Müller, Thomas; Mueller, Timo; Muenstermann, Daniel; Munwes, Yonathan; Murray, Bill; Mussche, Ido; Musto, Elisa; Myagkov, Alexey; Myska, Miroslav; Nadal, Jordi; Nagai, Koichi; Nagai, Ryo; Nagano, Kunihiro; Nagarkar, Advait; Nagasaka, Yasushi; Nagel, Martin; Nairz, Armin Michael; Nakahama, Yu; Nakamura, Koji; Nakamura, Tomoaki; Nakano, Itsuo; Nanava, Gizo; Napier, Austin; Narayan, Rohin; Nash, Michael; Nattermann, Till; Naumann, Thomas; Navarro, Gabriela; Neal, Homer; Nechaeva, Polina; Neep, Thomas James; Negri, Andrea; Negri, Guido; Negrini, Matteo; Nektarijevic, Snezana; Nelson, Andrew; Nelson, Timothy Knight; Nemecek, Stanislav; Nemethy, Peter; Nepomuceno, Andre Asevedo; Nessi, Marzio; Neubauer, Mark; Neumann, Manuel; Neusiedl, Andrea; Neves, Ricardo; Nevski, Pavel; Newman, Paul; Nguyen Thi Hong, Van; Nickerson, Richard; Nicolaidou, Rosy; Nicquevert, Bertrand; Niedercorn, Francois; Nielsen, Jason; Nikiforou, Nikiforos; Nikiforov, Andriy; Nikolaenko, Vladimir; Nikolic-Audit, Irena; Nikolics, Katalin; Nikolopoulos, Konstantinos; Nilsen, Henrik; Nilsson, Paul; Ninomiya, Yoichi; Nisati, Aleandro; Nisius, Richard; Nobe, Takuya; Nodulman, Lawrence; Nomachi, Masaharu; Nomidis, Ioannis; Norberg, Scarlet; Nordberg, Markus; Norton, Peter; Novakova, Jana; Nozaki, Mitsuaki; Nozka, Libor; Nugent, Ian Michael; Nuncio-Quiroz, Adriana-Elizabeth; Nunes Hanninger, Guilherme; Nunnemann, Thomas; Nurse, Emily; O'Brien, Brendan Joseph; O'Neale, Steve; O'Neil, Dugan; O'Shea, Val; Oakes, Louise Beth; Oakham, Gerald; Oberlack, Horst; Ocariz, Jose; Ochi, Atsuhiko; Oda, Susumu; Odaka, Shigeru; Odier, Jerome; Ogren, Harold; Oh, Alexander; Oh, Seog; Ohm, Christian; Ohshima, Takayoshi; Okawa, Hideki; Okumura, Yasuyuki; Okuyama, Toyonobu; Olariu, Albert; Olchevski, Alexander; Olivares Pino, Sebastian Andres; Oliveira, Miguel Alfonso; Oliveira Damazio, Denis; Oliver Garcia, Elena; Olivito, Dominick; Olszewski, Andrzej; Olszowska, Jolanta; Onofre, António; Onyisi, Peter; Oram, Christopher; Oreglia, Mark; Oren, Yona; Orestano, Domizia; Orlando, Nicola; Orlov, Iliya; Oropeza Barrera, Cristina; Orr, Robert; Osculati, Bianca; Ospanov, Rustem; Osuna, Carlos; Otero y Garzon, Gustavo; Ottersbach, John; Ouchrif, Mohamed; Ouellette, Eric; Ould-Saada, Farid; Ouraou, Ahmimed; Ouyang, Qun; Ovcharova, Ana; Owen, Mark; Owen, Simon; Ozcan, Veysi Erkcan; Ozturk, Nurcan; Pacheco Pages, Andres; Padilla Aranda, Cristobal; Pagan Griso, Simone; Paganis, Efstathios; Pahl, Christoph; Paige, Frank; Pais, Preema; Pajchel, Katarina; Palacino, Gabriel; Paleari, Chiara; Palestini, Sandro; Pallin, Dominique; Palma, Alberto; Palmer, Jody; Pan, Yibin; Panagiotopoulou, Evgenia; Pani, Priscilla; Panikashvili, Natalia; Panitkin, Sergey; Pantea, Dan; Papadelis, Aras; Papadopoulou, Theodora; Paramonov, Alexander; Paredes Hernandez, Daniela; Park, Woochun; Parker, Andy; Parodi, Fabrizio; Parsons, John; Parzefall, Ulrich; Pashapour, Shabnaz; Pasqualucci, Enrico; Passaggio, Stefano; Passeri, Antonio; Pastore, Fernanda; Pastore, Francesca; Pásztor, Gabriella; Pataraia, Sophio; Patel, Nikhul; Pater, Joleen; Patricelli, Sergio; Pauly, Thilo; Pecsy, Martin; Pedraza Lopez, Sebastian; Pedraza Morales, Maria Isabel; Peleganchuk, Sergey; Pelikan, Daniel; Peng, Haiping; Penning, Bjoern; Penson, Alexander; Penwell, John; Perantoni, Marcelo; Perez, Kerstin; Perez Cavalcanti, Tiago; Perez Codina, Estel; Pérez García-Estañ, María Teresa; Perez Reale, Valeria; Perini, Laura; Pernegger, Heinz; Perrino, Roberto; Perrodo, Pascal; Peshekhonov, Vladimir; Peters, Krisztian; Petersen, Brian; Petersen, Jorgen; Petersen, Troels; Petit, Elisabeth; Petridis, Andreas; Petridou, Chariclia; Petrolo, Emilio; Petrucci, Fabrizio; Petschull, Dennis; Petteni, Michele; Pezoa, Raquel; Phan, Anna; Phillips, Peter William; Piacquadio, Giacinto; Picazio, Attilio; Piccaro, Elisa; Piccinini, Maurizio; Piec, Sebastian Marcin; Piegaia, Ricardo; Pignotti, David; Pilcher, James; Pilkington, Andrew; Pina, João Antonio; Pinamonti, Michele; Pinder, Alex; Pinfold, James; Pinto, Belmiro; Pizio, Caterina; Plamondon, Mathieu; Pleier, Marc-Andre; Plotnikova, Elena; Poblaguev, Andrei; Poddar, Sahill; Podlyski, Fabrice; Poggioli, Luc; Pohl, David-leon; Pohl, Martin; Polesello, Giacomo; Policicchio, Antonio; Polini, Alessandro; Poll, James; Polychronakos, Venetios; Pomeroy, Daniel; Pommès, Kathy; Pontecorvo, Ludovico; Pope, Bernard; Popeneciu, Gabriel Alexandru; Popovic, Dragan; Poppleton, Alan; Portell Bueso, Xavier; Pospelov, Guennady; Pospisil, Stanislav; Potrap, Igor; Potter, Christina; Potter, Christopher; Poulard, Gilbert; Poveda, Joaquin; Pozdnyakov, Valery; Prabhu, Robindra; Pralavorio, Pascal; Pranko, Aliaksandr; Prasad, Srivas; Pravahan, Rishiraj; Prell, Soeren; Pretzl, Klaus Peter; Price, Darren; Price, Joe; Price, Lawrence; Prieur, Damien; Primavera, Margherita; Prokofiev, Kirill; Prokoshin, Fedor; Protopopescu, Serban; Proudfoot, James; Prudent, Xavier; Przybycien, Mariusz; Przysiezniak, Helenka; Psoroulas, Serena; Ptacek, Elizabeth; Pueschel, Elisa; Purdham, John; Purohit, Milind; Puzo, Patrick; Pylypchenko, Yuriy; Qian, Jianming; Quadt, Arnulf; Quarrie, David; Quayle, William; Quinonez, Fernando; Raas, Marcel; Radescu, Voica; Radloff, Peter; Rador, Tonguc; Ragusa, Francesco; Rahal, Ghita; Rahimi, Amir; Rahm, David; Rajagopalan, Srinivasan; Rammensee, Michael; Rammes, Marcus; Randle-Conde, Aidan Sean; Randrianarivony, Koloina; Rauscher, Felix; Rave, Tobias Christian; Raymond, Michel; Read, Alexander Lincoln; Rebuzzi, Daniela; Redelbach, Andreas; Redlinger, George; Reece, Ryan; Reeves, Kendall; Reinherz-Aronis, Erez; Reinsch, Andreas; Reisinger, Ingo; Rembser, Christoph; Ren, Zhongliang; Renaud, Adrien; Rescigno, Marco; Resconi, Silvia; Resende, Bernardo; Reznicek, Pavel; Rezvani, Reyhaneh; Richter, Robert; Richter-Was, Elzbieta; Ridel, Melissa; Rijpstra, Manouk; Rijssenbeek, Michael; Rimoldi, Adele; Rinaldi, Lorenzo; Rios, Ryan Randy; Riu, Imma; Rivoltella, Giancesare; Rizatdinova, Flera; Rizvi, Eram; Robertson, Steven; Robichaud-Veronneau, Andree; Robinson, Dave; Robinson, James; Robson, Aidan; Rocha de Lima, Jose Guilherme; Roda, Chiara; Roda Dos Santos, Denis; Roe, Adam; Roe, Shaun; Røhne, Ole; Rolli, Simona; Romaniouk, Anatoli; Romano, Marino; Romeo, Gaston; Romero Adam, Elena; Rompotis, Nikolaos; Roos, Lydia; Ros, Eduardo; Rosati, Stefano; Rosbach, Kilian; Rose, Anthony; Rose, Matthew; Rosenbaum, Gabriel; Rosenberg, Eli; Rosendahl, Peter Lundgaard; Rosenthal, Oliver; Rosselet, Laurent; Rossetti, Valerio; Rossi, Elvira; Rossi, Leonardo Paolo; Rotaru, Marina; Roth, Itamar; Rothberg, Joseph; Rousseau, David; Royon, Christophe; Rozanov, Alexander; Rozen, Yoram; Ruan, Xifeng; Rubbo, Francesco; Rubinskiy, Igor; Ruckstuhl, Nicole; Rud, Viacheslav; Rudolph, Christian; Rudolph, Gerald; Rühr, Frederik; Ruiz-Martinez, Aranzazu; Rumyantsev, Leonid; Rurikova, Zuzana; Rusakovich, Nikolai; Rutherfoord, John; Ruwiedel, Christoph; Ruzicka, Pavel; Ryabov, Yury; Rybar, Martin; Rybkin, Grigori; Ryder, Nick; Saavedra, Aldo; Sadeh, Iftach; Sadrozinski, Hartmut; Sadykov, Renat; Safai Tehrani, Francesco; Sakamoto, Hiroshi; Salamanna, Giuseppe; Salamon, Andrea; Saleem, Muhammad; Salek, David; Salihagic, Denis; Salnikov, Andrei; Salt, José; Salvachua Ferrando, Belén; Salvatore, Daniela; Salvatore, Pasquale Fabrizio; Salvucci, Antonio; Salzburger, Andreas; Sampsonidis, Dimitrios; Samset, Björn Hallvard; Sanchez, Arturo; Sanchez Martinez, Victoria; Sandaker, Heidi; Sander, Heinz Georg; Sanders, Michiel; Sandhoff, Marisa; Sandoval, Tanya; Sandoval, Carlos; Sandstroem, Rikard; Sankey, Dave; Sansoni, Andrea; Santamarina Rios, Cibran; Santoni, Claudio; Santonico, Rinaldo; Santos, Helena; Saraiva, João; Sarangi, Tapas; Sarkisyan-Grinbaum, Edward; Sarri, Francesca; Sartisohn, Georg; Sasaki, Osamu; Sasaki, Yuichi; Sasao, Noboru; Satsounkevitch, Igor; Sauvage, Gilles; Sauvan, Emmanuel; Sauvan, Jean-Baptiste; Savard, Pierre; Savinov, Vladimir; Savu, Dan Octavian; Sawyer, Lee; Saxon, David; Saxon, James; Sbarra, Carla; Sbrizzi, Antonio; Scannicchio, Diana; Scarcella, Mark; Schaarschmidt, Jana; Schacht, Peter; Schaefer, Douglas; Schäfer, Uli; Schaepe, Steffen; Schaetzel, Sebastian; Schaffer, Arthur; Schaile, Dorothee; Schamberger, R~Dean; Schamov, Andrey; Scharf, Veit; Schegelsky, Valery; Scheirich, Daniel; Schernau, Michael; Scherzer, Max; Schiavi, Carlo; Schieck, Jochen; Schioppa, Marco; Schlenker, Stefan; Schmidt, Evelyn; Schmieden, Kristof; Schmitt, Christian; Schmitt, Sebastian; Schmitz, Martin; Schneider, Basil; Schnoor, Ulrike; Schoening, Andre; Schorlemmer, Andre Lukas; Schott, Matthias; Schouten, Doug; Schovancova, Jaroslava; Schram, Malachi; Schroeder, Christian; Schroer, Nicolai; Schultens, Martin Johannes; Schultes, Joachim; Schultz-Coulon, Hans-Christian; Schulz, Holger; Schumacher, Markus; Schumm, Bruce; Schune, Philippe; Schwanenberger, Christian; Schwartzman, Ariel; Schwegler, Philipp; Schwemling, Philippe; Schwienhorst, Reinhard; Schwierz, Rainer; Schwindling, Jerome; Schwindt, Thomas; Schwoerer, Maud; Sciolla, Gabriella; Scott, Bill; Searcy, Jacob; Sedov, George; Sedykh, Evgeny; Seidel, Sally; Seiden, Abraham; Seifert, Frank; Seixas, José; Sekhniaidze, Givi; Sekula, Stephen; Selbach, Karoline Elfriede; Seliverstov, Dmitry; Sellden, Bjoern; Sellers, Graham; Seman, Michal; Semprini-Cesari, Nicola; Serfon, Cedric; Serin, Laurent; Serkin, Leonid; Seuster, Rolf; Severini, Horst; Sfyrla, Anna; Shabalina, Elizaveta; Shamim, Mansoora; Shan, Lianyou; Shank, James; Shao, Qi Tao; Shapiro, Marjorie; Shatalov, Pavel; Shaw, Kate; Sherman, Daniel; Sherwood, Peter; Shibata, Akira; Shimizu, Shima; Shimojima, Makoto; Shin, Taeksu; Shiyakova, Maria; Shmeleva, Alevtina; Shochet, Mel; Short, Daniel; Shrestha, Suyog; Shulga, Evgeny; Shupe, Michael; Sicho, Petr; Sidoti, Antonio; Siegert, Frank; Sijacki, Djordje; Silbert, Ohad; Silva, José; Silver, Yiftah; Silverstein, Daniel; Silverstein, Samuel; Simak, Vladislav; Simard, Olivier; Simic, Ljiljana; Simion, Stefan; Simioni, Eduard; Simmons, Brinick; Simoniello, Rosa; Simonyan, Margar; Sinervo, Pekka; Sinev, Nikolai; Sipica, Valentin; Siragusa, Giovanni; Sircar, Anirvan; Sisakyan, Alexei; Sivoklokov, Serguei; Sjölin, Jörgen; Sjursen, Therese; Skinnari, Louise Anastasia; Skottowe, Hugh Philip; Skovpen, Kirill; Skubic, Patrick; Slater, Mark; Slavicek, Tomas; Sliwa, Krzysztof; Smakhtin, Vladimir; Smart, Ben; Smirnov, Sergei; Smirnov, Yury; Smirnova, Lidia; Smirnova, Oxana; Smith, Ben Campbell; Smith, Douglas; Smith, Kenway; Smizanska, Maria; Smolek, Karel; Snesarev, Andrei; Snow, Steve; Snow, Joel; Snyder, Scott; Sobie, Randall; Sodomka, Jaromir; Soffer, Abner; Solans, Carlos; Solar, Michael; Solc, Jaroslav; Soldatov, Evgeny; Soldevila, Urmila; Solfaroli Camillocci, Elena; Solodkov, Alexander; Solovyanov, Oleg; Solovyev, Victor; Soni, Nitesh; Sopko, Vit; Sopko, Bruno; Sosebee, Mark; Soualah, Rachik; Soukharev, Andrey; Spagnolo, Stefania; Spanò, Francesco; Spighi, Roberto; Spigo, Giancarlo; Spiwoks, Ralf; Spousta, Martin; Spreitzer, Teresa; Spurlock, Barry; St Denis, Richard Dante; Stahlman, Jonathan; Stamen, Rainer; Stanecka, Ewa; Stanek, Robert; Stanescu, Cristian; Stanescu-Bellu, Madalina; Stapnes, Steinar; Starchenko, Evgeny; Stark, Jan; Staroba, Pavel; Starovoitov, Pavel; Staszewski, Rafal; Staude, Arnold; Stavina, Pavel; Steele, Genevieve; Steinbach, Peter; Steinberg, Peter; Stekl, Ivan; Stelzer, Bernd; Stelzer, Harald Joerg; Stelzer-Chilton, Oliver; Stenzel, Hasko; Stern, Sebastian; Stewart, Graeme; Stillings, Jan Andre; Stockton, Mark; Stoerig, Kathrin; Stoicea, Gabriel; Stonjek, Stefan; Strachota, Pavel; Stradling, Alden; Straessner, Arno; Strandberg, Jonas; Strandberg, Sara; Strandlie, Are; Strang, Michael; Strauss, Emanuel; Strauss, Michael; Strizenec, Pavol; Ströhmer, Raimund; Strom, David; Strong, John; Stroynowski, Ryszard; Strube, Jan; Stugu, Bjarne; Stumer, Iuliu; Stupak, John; Sturm, Philipp; Styles, Nicholas Adam; Soh, Dart-yin; Su, Dong; Subramania, Halasya Siva; Succurro, Antonella; Sugaya, Yorihito; Suhr, Chad; Suk, Michal; Sulin, Vladimir; Sultansoy, Saleh; Sumida, Toshi; Sun, Xiaohu; Sundermann, Jan Erik; Suruliz, Kerim; Susinno, Giancarlo; Sutton, Mark; Suzuki, Yu; Suzuki, Yuta; Svatos, Michal; Swedish, Stephen; Sykora, Ivan; Sykora, Tomas; Sánchez, Javier; Ta, Duc; Tackmann, Kerstin; Taffard, Anyes; Tafirout, Reda; Taiblum, Nimrod; Takahashi, Yuta; Takai, Helio; Takashima, Ryuichi; Takeda, Hiroshi; Takeshita, Tohru; Takubo, Yosuke; Talby, Mossadek; Talyshev, Alexey; Tamsett, Matthew; Tanaka, Junichi; Tanaka, Reisaburo; Tanaka, Satoshi; Tanaka, Shuji; Tanasijczuk, Andres Jorge; Tani, Kazutoshi; Tannoury, Nancy; Tapprogge, Stefan; Tardif, Dominique; Tarem, Shlomit; Tarrade, Fabien; Tartarelli, Giuseppe Francesco; Tas, Petr; Tasevsky, Marek; Tassi, Enrico; Tatarkhanov, Mous; Tayalati, Yahya; Taylor, Christopher; Taylor, Frank; Taylor, Geoffrey; Taylor, Wendy; Teinturier, Marthe; Teischinger, Florian Alfred; Teixeira Dias Castanheira, Matilde; Teixeira-Dias, Pedro; Temming, Kim Katrin; Ten Kate, Herman; Teng, Ping-Kun; Terada, Susumu; Terashi, Koji; Terron, Juan; Testa, Marianna; Teuscher, Richard; Therhaag, Jan; Theveneaux-Pelzer, Timothée; Thoma, Sascha; Thomas, Juergen; Thompson, Emily; Thompson, Paul; Thompson, Peter; Thompson, Stan; Thomsen, Lotte Ansgaard; Thomson, Evelyn; Thomson, Mark; Thong, Wai Meng; Thun, Rudolf; Tian, Feng; Tibbetts, Mark James; Tic, Tomáš; Tikhomirov, Vladimir; Tikhonov, Yury; Timoshenko, Sergey; Tipton, Paul; Tisserant, Sylvain; Todorov, Theodore; Todorova-Nova, Sharka; Toggerson, Brokk; Tojo, Junji; Tokár, Stanislav; Tokushuku, Katsuo; Tollefson, Kirsten; Tomoto, Makoto; Tompkins, Lauren; Toms, Konstantin; Tonoyan, Arshak; Topfel, Cyril; Topilin, Nikolai; Torchiani, Ingo; Torrence, Eric; Torres, Heberth; Torró Pastor, Emma; Toth, Jozsef; Touchard, Francois; Tovey, Daniel; Trefzger, Thomas; Tremblet, Louis; Tricoli, Alesandro; Trigger, Isabel Marian; Trincaz-Duvoid, Sophie; Tripiana, Martin; Triplett, Nathan; Trischuk, William; Trocmé, Benjamin; Troncon, Clara; Trottier-McDonald, Michel; Trzebinski, Maciej; Trzupek, Adam; Tsarouchas, Charilaos; Tseng, Jeffrey; Tsiakiris, Menelaos; Tsiareshka, Pavel; Tsionou, Dimitra; Tsipolitis, Georgios; Tsiskaridze, Shota; Tsiskaridze, Vakhtang; Tskhadadze, Edisher; Tsukerman, Ilya; Tsulaia, Vakhtang; Tsung, Jieh-Wen; Tsuno, Soshi; Tsybychev, Dmitri; Tua, Alan; Tudorache, Alexandra; Tudorache, Valentina; Tuggle, Joseph; Turala, Michal; Turecek, Daniel; Turk Cakir, Ilkay; Turlay, Emmanuel; Turra, Ruggero; Tuts, Michael; Tykhonov, Andrii; Tylmad, Maja; Tyndel, Mike; Tzanakos, George; Uchida, Kirika; Ueda, Ikuo; Ueno, Ryuichi; Ugland, Maren; Uhlenbrock, Mathias; Uhrmacher, Michael; Ukegawa, Fumihiko; Unal, Guillaume; Undrus, Alexander; Unel, Gokhan; Unno, Yoshinobu; Urbaniec, Dustin; Usai, Giulio; Uslenghi, Massimiliano; Vacavant, Laurent; Vacek, Vaclav; Vachon, Brigitte; Vahsen, Sven; Valenta, Jan; Valentinetti, Sara; Valero, Alberto; Valkar, Stefan; Valladolid Gallego, Eva; Vallecorsa, Sofia; Valls Ferrer, Juan Antonio; Van Der Deijl, Pieter; van der Geer, Rogier; van der Graaf, Harry; Van Der Leeuw, Robin; van der Poel, Egge; van der Ster, Daniel; van Eldik, Niels; van Gemmeren, Peter; van Vulpen, Ivo; Vanadia, Marco; Vandelli, Wainer; Vaniachine, Alexandre; Vankov, Peter; Vannucci, Francois; Vari, Riccardo; Varol, Tulin; Varouchas, Dimitris; Vartapetian, Armen; Varvell, Kevin; Vassilakopoulos, Vassilios; Vazeille, Francois; Vazquez Schroeder, Tamara; Vegni, Guido; Veillet, Jean-Jacques; Veloso, Filipe; Veness, Raymond; Veneziano, Stefano; Ventura, Andrea; Ventura, Daniel; Venturi, Manuela; Venturi, Nicola; Vercesi, Valerio; Verducci, Monica; Verkerke, Wouter; Vermeulen, Jos; Vest, Anja; Vetterli, Michel; Vichou, Irene; Vickey, Trevor; Vickey Boeriu, Oana Elena; Viehhauser, Georg; Viel, Simon; Villa, Mauro; Villaplana Perez, Miguel; Vilucchi, Elisabetta; Vincter, Manuella; Vinek, Elisabeth; Vinogradov, Vladimir; Virchaux, Marc; Virzi, Joseph; Vitells, Ofer; Viti, Michele; Vivarelli, Iacopo; Vives Vaque, Francesc; Vlachos, Sotirios; Vladoiu, Dan; Vlasak, Michal; Vogel, Adrian; Vokac, Petr; Volpi, Guido; Volpi, Matteo; Volpini, Giovanni; von der Schmitt, Hans; von Radziewski, Holger; von Toerne, Eckhard; Vorobel, Vit; Vorwerk, Volker; Vos, Marcel; Voss, Rudiger; Voss, Thorsten Tobias; Vossebeld, Joost; Vranjes, Nenad; Vranjes Milosavljevic, Marija; Vrba, Vaclav; Vreeswijk, Marcel; Vu Anh, Tuan; Vuillermet, Raphael; Vukotic, Ilija; Wagner, Wolfgang; Wagner, Peter; Wahlen, Helmut; Wahrmund, Sebastian; Wakabayashi, Jun; Walch, Shannon; Walder, James; Walker, Rodney; Walkowiak, Wolfgang; Wall, Richard; Waller, Peter; Walsh, Brian; Wang, Chiho; Wang, Haichen; Wang, Hulin; Wang, Jike; Wang, Jin; Wang, Rui; Wang, Song-Ming; Wang, Tan; Warburton, Andreas; Ward, Patricia; Warsinsky, Markus; Washbrook, Andrew; Wasicki, Christoph; Watanabe, Ippei; Watkins, Peter; Watson, Alan; Watson, Ian; Watson, Miriam; Watts, Gordon; Watts, Stephen; Waugh, Anthony; Waugh, Ben; Weber, Michele; Weber, Pavel; Weidberg, Anthony; Weigell, Philipp; Weingarten, Jens; Weiser, Christian; Wellenstein, Hermann; Wells, Phillippa; Wenaus, Torre; Wendland, Dennis; Weng, Zhili; Wengler, Thorsten; Wenig, Siegfried; Wermes, Norbert; Werner, Matthias; Werner, Per; Werth, Michael; Wessels, Martin; Wetter, Jeffrey; Weydert, Carole; Whalen, Kathleen; Wheeler-Ellis, Sarah Jane; White, Andrew; White, Martin; White, Sebastian; Whitehead, Samuel Robert; Whiteson, Daniel; Whittington, Denver; Wicek, Francois; Wicke, Daniel; Wickens, Fred; Wiedenmann, Werner; Wielers, Monika; Wienemann, Peter; Wiglesworth, Craig; Wiik-Fuchs, Liv Antje Mari; Wijeratne, Peter Alexander; Wildauer, Andreas; Wildt, Martin Andre; Wilhelm, Ivan; Wilkens, Henric George; Will, Jonas Zacharias; Williams, Eric; Williams, Hugh; Willis, William; Willocq, Stephane; Wilson, John; Wilson, Michael Galante; Wilson, Alan; Wingerter-Seez, Isabelle; Winkelmann, Stefan; Winklmeier, Frank; Wittgen, Matthias; Wollstadt, Simon Jakob; Wolter, Marcin Wladyslaw; Wolters, Helmut; Wong, Wei-Cheng; Wooden, Gemma; Wosiek, Barbara; Wotschack, Jorg; Woudstra, Martin; Wozniak, Krzysztof; Wraight, Kenneth; Wright, Michael; Wrona, Bozydar; Wu, Sau Lan; Wu, Xin; Wu, Yusheng; Wulf, Evan; Wynne, Benjamin; Xella, Stefania; Xiao, Meng; Xie, Song; Xu, Chao; Xu, Da; Yabsley, Bruce; Yacoob, Sahal; Yamada, Miho; Yamaguchi, Hiroshi; Yamamoto, Akira; Yamamoto, Kyoko; Yamamoto, Shimpei; Yamamura, Taiki; Yamanaka, Takashi; Yamaoka, Jared; Yamazaki, Takayuki; Yamazaki, Yuji; Yan, Zhen; Yang, Haijun; Yang, Un-Ki; Yang, Yi; Yang, Zhaoyu; Yanush, Serguei; Yao, Liwen; Yao, Yushu; Yasu, Yoshiji; Ybeles Smit, Gabriel Valentijn; Ye, Jingbo; Ye, Shuwei; Yilmaz, Metin; Yoosoofmiya, Reza; Yorita, Kohei; Yoshida, Riktura; Young, Charles; Young, Christopher John; Youssef, Saul; Yu, Dantong; Yu, Jaehoon; Yu, Jie; Yuan, Li; Yurkewicz, Adam; Zabinski, Bartlomiej; Zaidan, Remi; Zaitsev, Alexander; Zajacova, Zuzana; Zanello, Lucia; Zanzi, Daniele; Zaytsev, Alexander; Zeitnitz, Christian; Zeman, Martin; Zemla, Andrzej; Zendler, Carolin; Zenin, Oleg; Ženiš, Tibor; Zinonos, Zinonas; Zenz, Seth; Zerwas, Dirk; Zevi della Porta, Giovanni; Zhan, Zhichao; Zhang, Dongliang; Zhang, Huaqiao; Zhang, Jinlong; Zhang, Xueyao; Zhang, Zhiqing; Zhao, Long; Zhao, Tianchi; Zhao, Zhengguo; Zhemchugov, Alexey; Zhong, Jiahang; Zhou, Bing; Zhou, Ning; Zhou, Yue; Zhu, Cheng Guang; Zhu, Hongbo; Zhu, Junjie; Zhu, Yingchun; Zhuang, Xuai; Zhuravlov, Vadym; Zieminska, Daria; Zimin, Nikolai; Zimmermann, Robert; Zimmermann, Simone; Zimmermann, Stephanie; Ziolkowski, Michael; Zitoun, Robert; Živković, Lidija; Zmouchko, Viatcheslav; Zobernig, Georg; Zoccoli, Antonio; zur Nedden, Martin; Zutshi, Vishnu; Zwalinski, Lukasz
2012-01-01
A measurement of $B_s^0 \\to J/\\psi \\phi$ decay parameters, including the CP-violating weak phase $\\phi_s$ and the decay width difference $\\Delta \\Gamma_s$ is reported, using 4.9 fb$^{-1}$ of integrated luminosity collected in 2011 by the ATLAS detector from LHC pp collisions at a centre-of-mass energy $\\sqrt{s}$ = 7 TeV. The mean decay width $\\Gamma_s$ and the transversity amplitudes $|A_0(0)|^2$ and $|A_{||}(0)|^2$ are also measured. The values reported for these parameters are: \\begin{eqnarray}\\cr \\phi_s = 0.22 \\pm 0.41 (stat.) \\pm 0.10 (syst.) rad\\cr \\Delta \\Gamma_s = 0.053 \\pm 0.021 (stat.) \\pm 0.008 (syst.) ps^{-1}\\cr \\Gamma_s = 0.677 \\pm 0.007 (stat.) \\pm 0.004 (syst.) ps^{-1}\\cr |A_0(0)|^2 = 0.528 \\pm 0.006 (stat.) \\pm 0.009 (syst.)\\cr |A_{||}(0)|^2 = 0.220 \\pm 0.008 (stat.) \\pm 0.007 (syst.)\\cr\\end{eqnarray} where the values quoted for $\\phi_s$ and $\\Delta \\Gamma_s$ correspond to the solution compatible with the external measurements to which the strong phase $\\delta$ perpendicular is constrained and ...
Weak Signal Detection Based on Phase Locked Loop and Chaotic Oscillator%基于锁相环和浞沌振子的微弱信号检测
张瑜; 贺秋瑞
2012-01-01
In order to detect accurately the amplitude and frequency of a nV-level sine signal,a hybrid detection system of weak signal based on phase locked loop and chaotic oscillator was built.First,by locking the measured signal which is input to phase locked loop,the signal frequency detection is completed.Then,taking the phase locked loop output signal whose frequency is known as the internal motive power signal of the chaos system,the amplitude of the input measured signal to the chaos system can be detected by Duffing oscillator.Simulation results show that: the hybrid system can detect the frequency and the amplitude of a nv-level weak signal at the same time; the lowest SNR of the signal is -22.23dB,and the hybrid system is easy to operate,which needs small amount of work and is easy to realize.%为精确检测纳伏级微弱正弦信号的频率和幅值,构建了基于锁相环和Duffing振子的微弱信号混合检测系统.首先通过锁定输入锁相环的待测信号,完成信号频率的检测;然后利用锁相环输出的已知频率信号作为混沌系统的内置策动力信号,将输入到混沌系统的待测信号用Duffing振子进行幅值检测.仿真结果表明,混合系统可同时完成纳伏级微弱正弦信号的频率和幅值的检测,检测信号的最低信噪比为-22.23dB,且操作简单,工作量小,易于实现.
Jesse, Stephen [ORNL; Mirman, B [Suffolk University, Boston; Kalinin, Sergei V [ORNL
2006-01-01
Piezoresponse force microscopy (PFM) and spectroscopy of domain structure and switching dynamics at small excitation voltages require resonance enhancement of the surface displacements. The contact stiffness depends strongly on local elastic properties and topography resulting in significant variations of the resonant frequency. Moreover, the resonant response is determined both by the Q factor and the electromechanical activity. Here we develop a resonance-enhanced PFM that allows mapping of the local electromechanical activity, contact stiffness, and loss factor, thus avoiding limitations inherent to conventional frequency tracking. We anticipate that this method will be instrumental in imaging weakly piezoelectric materials and probing inelastic phenomena in ferroelectrics.
Hosoya, Akio
2010-01-01
We develop a formal theory of the weak values with emphasis on the consistency conditions and a probabilistic interpretation in the counter-factual processes. We present the condition for the choice of the post-selected state to give a negative weak value of a given projection operator and strange values of an observable in general. The general framework is applied to Hardy's paradox and the spin $1/2$ system to explicitly address the issues of counter-factuality and strange weak values. The counter-factual arguments which characterize the paradox specifies the pre-selected state and a complete set of the post-selected states clarifies how the strange weak values emerge.
Effects of Quadriceps Muscle Fatigue on Stiff-Knee Gait in Patients with Hemiparesis
Boudarham, Julien; Roche, Nicolas; Pradon, Didier; Delouf, Eric; Bensmail, Djamel; Zory, Raphael
2014-01-01
The relationship between neuromuscular fatigue and locomotion has never been investigated in hemiparetic patients despite the fact that, in the clinical context, patients report to be more spastic or stiffer after walking a long distance or after a rehabilitation session. The aim of this study was to evaluate the effects of quadriceps muscle fatigue on the biomechanical gait parameters of patients with a stiff-knee gait (SKG). Thirteen patients and eleven healthy controls performed one gait analysis before a protocol of isokinetic quadriceps fatigue and two after (immediately after and after 10 minutes of rest). Spatiotemporal parameters, sagittal knee and hip kinematics, rectus femoris (RF) and vastus lateralis (VL) kinematics and electromyographic (EMG) activity were analyzed. The results showed that quadriceps muscle weakness, produced by repetitive concentric contractions of the knee extensors, induced an improvement of spatiotemporal parameters for patients and healthy subjects. For the patient group, the increase in gait velocity and step length was associated with i) an increase of sagittal hip and knee flexion during the swing phase, ii) an increase of the maximal normalized length of the RF and VL and of the maximal VL lengthening velocity during the pre-swing and swing phases, and iii) a decrease in EMG activity of the RF muscle during the initial pre-swing phase and during the latter 2/3 of the initial swing phase. These results suggest that quadriceps fatigue did not alter the gait of patients with hemiparesis walking with a SKG and that neuromuscular fatigue may play the same functional role as an anti-spastic treatment such as botulinum toxin-A injection. Strength training of knee extensors, although commonly performed in rehabilitation, does not seem to be a priority to improve gait of these patients. PMID:24718087
Effects of quadriceps muscle fatigue on stiff-knee gait in patients with hemiparesis.
Julien Boudarham
Full Text Available The relationship between neuromuscular fatigue and locomotion has never been investigated in hemiparetic patients despite the fact that, in the clinical context, patients report to be more spastic or stiffer after walking a long distance or after a rehabilitation session. The aim of this study was to evaluate the effects of quadriceps muscle fatigue on the biomechanical gait parameters of patients with a stiff-knee gait (SKG. Thirteen patients and eleven healthy controls performed one gait analysis before a protocol of isokinetic quadriceps fatigue and two after (immediately after and after 10 minutes of rest. Spatiotemporal parameters, sagittal knee and hip kinematics, rectus femoris (RF and vastus lateralis (VL kinematics and electromyographic (EMG activity were analyzed. The results showed that quadriceps muscle weakness, produced by repetitive concentric contractions of the knee extensors, induced an improvement of spatiotemporal parameters for patients and healthy subjects. For the patient group, the increase in gait velocity and step length was associated with i an increase of sagittal hip and knee flexion during the swing phase, ii an increase of the maximal normalized length of the RF and VL and of the maximal VL lengthening velocity during the pre-swing and swing phases, and iii a decrease in EMG activity of the RF muscle during the initial pre-swing phase and during the latter 2/3 of the initial swing phase. These results suggest that quadriceps fatigue did not alter the gait of patients with hemiparesis walking with a SKG and that neuromuscular fatigue may play the same functional role as an anti-spastic treatment such as botulinum toxin-A injection. Strength training of knee extensors, although commonly performed in rehabilitation, does not seem to be a priority to improve gait of these patients.
Effects of quadriceps muscle fatigue on stiff-knee gait in patients with hemiparesis.
Boudarham, Julien; Roche, Nicolas; Pradon, Didier; Delouf, Eric; Bensmail, Djamel; Zory, Raphael
2014-01-01
The relationship between neuromuscular fatigue and locomotion has never been investigated in hemiparetic patients despite the fact that, in the clinical context, patients report to be more spastic or stiffer after walking a long distance or after a rehabilitation session. The aim of this study was to evaluate the effects of quadriceps muscle fatigue on the biomechanical gait parameters of patients with a stiff-knee gait (SKG). Thirteen patients and eleven healthy controls performed one gait analysis before a protocol of isokinetic quadriceps fatigue and two after (immediately after and after 10 minutes of rest). Spatiotemporal parameters, sagittal knee and hip kinematics, rectus femoris (RF) and vastus lateralis (VL) kinematics and electromyographic (EMG) activity were analyzed. The results showed that quadriceps muscle weakness, produced by repetitive concentric contractions of the knee extensors, induced an improvement of spatiotemporal parameters for patients and healthy subjects. For the patient group, the increase in gait velocity and step length was associated with i) an increase of sagittal hip and knee flexion during the swing phase, ii) an increase of the maximal normalized length of the RF and VL and of the maximal VL lengthening velocity during the pre-swing and swing phases, and iii) a decrease in EMG activity of the RF muscle during the initial pre-swing phase and during the latter 2/3 of the initial swing phase. These results suggest that quadriceps fatigue did not alter the gait of patients with hemiparesis walking with a SKG and that neuromuscular fatigue may play the same functional role as an anti-spastic treatment such as botulinum toxin-A injection. Strength training of knee extensors, although commonly performed in rehabilitation, does not seem to be a priority to improve gait of these patients.
Genetic determinants of arterial stiffness: Results from the Rotterdam Study
M.P.S. Sie (Mark)
2007-01-01
textabstractArterial stiffness increases with age. It is also associated with various diseases, such as diabetes mellitus and hypertension. Recently, arterial stiffness has also been found to independently predict cardiovascular disease. The pathogenesis of arterial stiffness, however, has n
Influence of the addendum modification on spur gear back-side mesh stiffness and dynamics
Yu, Wennian; Mechefske, Chris K.; Timusk, Markus
2017-02-01
This paper analytically investigates the relationship between the drive-side and back-side mesh stiffness for spur gear pairs with various addendum modifications. A time-varying asymmetric mesh stiffness model was built and employed in two typical gear dynamic models to simulate the effect of the addendum modification on gear dynamics. The results reveal that correlation of the back-side mesh stiffness with drive-side mesh stiffness is mainly affected by the tooth thickness at the pitch circle. Since tooth addendum modification directly determines the tooth thickness at the pitch circle, it significantly influences gear back-side tooth impact as it can alter the phase shift of the back-side mesh stiffness with regard to the drive-side mesh stiffness. Therefore, a precise time-varying asymmetric mesh stiffness model should be used to analyze gear dynamics when the gears are working under light load or idling conditions where back-side tooth impact is most likely to happen.
刘桂花; 曹小娇; 王卫
2015-01-01
One of the main electrical characteristics of weak grid is the high grid impedance, which will easily lead to grid voltage waveform distortion. Distorted grid voltage can resultin deviation or failure of the phase-locked loop of photovoltaic (PV) inverter, and power quality will deteriorate. In order to tackle this problem, targeting on the LC-type PV inverter,a synchronization method is proposed based on the second order generalized integrator frequency locked loop (SOGI-FLL). Initially, the impact of various grid states, especially the weak grid, on the inverter is analyzed. Then the operation principle of SOGI-FLL and its implementation method are set forth in detail. Simulation and experimental results demonstrate the validity of this synchronization method in grid voltage disturbance and zero-crossing oscillation. This synchronization method has strong robustness and adaptability for grid voltage changes. Compared with the conventional zero-crossing synchronization method, the SOGI-FLL synchronization method can improve the reliability of grid-connected PV inverters under weak grid.%弱电网的主要电气特性之一为高电网阻抗.高电网阻抗易导致电网电压波形畸变,畸变的电网电压会使光伏并网逆变器锁相环出现偏差甚至失效,并导致并网电能质量变差.针对这一问题,以LC型单相光伏并网逆变器为研究对象,提出采用基于2阶广义积分器锁频环(second order generalized integrator frequency locked loop,SOGI-FLL)同步方法来实现逆变器与弱电网的同步.在分析不同电网状态尤其是弱电网对逆变器影响的基础上,详细阐述SOGI-FLL的工作原理和实现方法.仿真和实验结果表明,该同步方法在电网电压扰动及过零点震荡情况下均可稳定可靠工作,对电网电压变化具有较强的鲁棒性和适应性,与传统过零同步方法相比,SOGI-FLL同步方法可提高弱电网下光伏并网逆变器的可靠性.
Stiff substrates enhance cultured neuronal network activity.
Zhang, Quan-You; Zhang, Yan-Yan; Xie, Jing; Li, Chen-Xu; Chen, Wei-Yi; Liu, Bai-Lin; Wu, Xiao-an; Li, Shu-Na; Huo, Bo; Jiang, Lin-Hua; Zhao, Hu-Cheng
2014-08-28
The mechanical property of extracellular matrix and cell-supporting substrates is known to modulate neuronal growth, differentiation, extension and branching. Here we show that substrate stiffness is an important microenvironmental cue, to which mouse hippocampal neurons respond and integrate into synapse formation and transmission in cultured neuronal network. Hippocampal neurons were cultured on polydimethylsiloxane substrates fabricated to have similar surface properties but a 10-fold difference in Young's modulus. Voltage-gated Ca(2+) channel currents determined by patch-clamp recording were greater in neurons on stiff substrates than on soft substrates. Ca(2+) oscillations in cultured neuronal network monitored using time-lapse single cell imaging increased in both amplitude and frequency among neurons on stiff substrates. Consistently, synaptic connectivity recorded by paired recording was enhanced between neurons on stiff substrates. Furthermore, spontaneous excitatory postsynaptic activity became greater and more frequent in neurons on stiff substrates. Evoked excitatory transmitter release and excitatory postsynaptic currents also were heightened at synapses between neurons on stiff substrates. Taken together, our results provide compelling evidence to show that substrate stiffness is an important biophysical factor modulating synapse connectivity and transmission in cultured hippocampal neuronal network. Such information is useful in designing instructive scaffolds or supporting substrates for neural tissue engineering.
Dynamic stiffness of suction caissons - vertical vibrations
Ibsen, Lars Bo; Liingaard, M.; Andersen, Lars
2006-12-15
The dynamic response of offshore wind turbines are affected by the properties of the foundation and the subsoil. The purpose of this report is to evaluate the dynamic soil-structure interaction of suction caissons for offshore wind turbines. The investigation is limited to a determination of the vertical dynamic stiffness of suction caissons. The soil surrounding the foundation is homogenous with linear viscoelastic properties. The dynamic stiffness of the suction caisson is expressed by dimensionless frequency-dependent dynamic stiffness coefficients corresponding to the vertical degree of freedom. The dynamic stiffness coefficients for the foundations are evaluated by means of a dynamic three-dimensional coupled Boundary Element/Finite Element model. Comparisons are made with known analytical and numerical solutions in order to evaluate the static and dynamic behaviour of the Boundary Element/Finite Element model. The vertical frequency dependent stiffness has been determined for different combinations of the skirt length, Poisson's ratio and the ratio between soil stiffness and skirt stiffness. Finally the dynamic behaviour at high frequencies is investigated. (au)
Weak stripe domains vibrations description using Thiele equation
Talbi, Y; Roussigne, Y; Djemia, P; Labrune, M, E-mail: talbi@1pmtm.univ-paris13.f [Laboratoire PMTM, CNRS UPR 9001, Universite Paris 13, 93430 Villetaneuse (France)
2010-01-01
We have performed strip line ferromagnetic resonance on weak stripe domains in permalloy layers. We used Thiele equation of motion to interprete our experimental data : the lowest frequency mode corresponds to the motion of vortices inside the layer, its frequency is evaluated through the relation {omega} = k/G where G is the gyrovector magnitude and k is a stiffness which mainly depends on demagnetizing effects.
Accelerated Solutions for Transcendental Stiffness Matrix Eigenproblems
F.W. Williams
1996-01-01
Full Text Available This article outlines many existing and forthcoming methods that can be used alone, or in various combinations, to accelerate the solutions of the transcendental stiffness matrix eigenproblems that arise when the stiffness matrix is assembled from exact member stiffnesses, which are obtained by solving the member differential equations exactly. Thus distributed member mass and/or the flexural effect of axial loading are incorporated exactly, and the solutions are the natural frequencies for vibration problems or the critical load factors for buckling problems.
Strength and stiffness variation of frozen soils according to confinement during freezing
SangYeob Kim; JongSub Lee
2015-01-01
When water between soil particles is frozen, the strength and stiffness behavior of soils significantly change. Thus, nu-merous experimental studies in the laboratory have been carried out to characterize the strength and stiffness of frozen soils. The goals of this study are to evaluate the strength characteristics of frozen soils, which underwent confinement in freezing and shearing stages, and to estimate the stiffness variation by shear wave velocity during shear phase. The specimens are prepared in a brass cell by mixing sand and silt with 10% degree of saturation at a relative density of 60%. The applied normal stresses as confining stresses are 5, 10, 25 and 50 kPa. When the temperature of the specimens is lowered up to−5 °C, direct shear tests are carried out. Furthermore, shear waves are continuously measured through bender elements during shearing stage for the investigation of stiffness change. Test results show that shear strength and stiffness are significantly affected by the confining stress in freezing and shearing phases. This study suggests that the strength and stiffness of frozen soils may be dependent on the confining stresses applied during freezing and shearing.
Stiffness matrix determination of composite materials using lamb wave group velocity measurements
Putkis, O.; Croxford, A. J.
2013-04-01
The use of Lamb waves in Non-Destructive Evaluation (NDE) and Structural Health Monitoring (SHM) is gaining popularity due to their ability to travel long distances without significant attenuation, therefore offering large area inspections with a small number of sensors. The design of a Lamb-wave-based NDE/SHM system for composite materials is more complicated than for metallic materials due to the directional dependence of Lamb wave propagation characteristics such as dispersion and group velocity. Propagation parameters can be theoretically predicted from known material properties, specifically the stiffness matrix and density. However, in practice it is difficult to obtain the stiffness matrix of a particular material or structure with high accuracy, hence introducing errors in theoretical predictions and inaccuracies in the resulting propagation parameters. Measured Lamb wave phase velocities can be used to infer the stiffness matrix, but the measurements are limited to the principal directions due to the steering effect (different propagation directions of phase and corresponding group velocities). This paper proposes determination of the stiffness matrix from the measured group velocities, which can be unambiguously measured in any direction. A highly anisotropic carbon-fibre-reinforced polymer plate is chosen for the study. The influence of different stiffness matrix elements on the directional group velocity profile is investigated. Thermodynamic Simulated Annealing (TSA) is used as a tool for inverse, multi variable inference of the stiffness matrix. A good estimation is achieved for particular matrix elements.
Zondervan, Robert L; Popovich, John M; Radcliffe, Clark J; Pathak, Pramod K; Reeves, N Peter
2016-02-29
While the impact of load magnitude on spine dynamic parameters (stiffness and damping) has been reported, it is unclear how load history (exposure to prolonged loading) affects spine dynamic parameters in sagittal rotation. Furthermore, it is unknown if both spine stiffness and damping are equally affected to prolonged loading. Using a pendulum testing apparatus, the effect of load magnitude and load history on spine sagittal rotational stiffness and damping was assessed. Nine porcine lumbar functional spine units (FSUs) were tested in an increasing compressive load phase (ICP: 44.85, 68.55, 91.75, 114.6kg) and then a decreasing compressive load phase (DCP: 91.75, 68.55, and 44.85kg). Each trial consisted of flexing the FSU 5° and allowing it to oscillate unconstrained. During the ICP, both stiffness and damping linearly increased with load. However, in the DCP, stiffness and damping values were significantly higher than the identical load collected during the ICP, suggesting load history affects sagittal rotational dynamic parameters. In addition, spine damping was more affected by load history than spine stiffness. These results highlight the importance of controlling load magnitude and history when assessing spine dynamic parameters.
Joyal, André
2009-01-01
We define weak units in a semi-monoidal 2-category $\\CC$ as cancellable pseudo-idempotents: they are pairs $(I,\\alpha)$ where $I$ is an object such that tensoring with $I$ from either side constitutes a biequivalence of $\\CC$, and $\\alpha: I \\tensor I \\to I$ is an equivalence in $\\CC$. We show that this notion of weak unit has coherence built in: Theorem A: $\\alpha$ has a canonical associator 2-cell, which automatically satisfies the pentagon equation. Theorem B: every morphism of weak units is automatically compatible with those associators. Theorem C: the 2-category of weak units is contractible if non-empty. Finally we show (Theorem E) that the notion of weak unit is equivalent to the notion obtained from the definition of tricategory: $\\alpha$ alone induces the whole family of left and right maps (indexed by the objects), as well as the whole family of Kelly 2-cells (one for each pair of objects), satisfying the relevant coherence axioms.
Vaibhavi Umesh
Full Text Available The aggressive and rapidly lethal brain tumor glioblastoma (GBM is associated with profound tissue stiffening and genomic lesions in key members of the epidermal growth factor receptor (EGFR pathway. Previous studies from our laboratory have shown that increasing microenvironmental stiffness in culture can strongly enhance glioma cell behaviors relevant to tumor progression, including proliferation, yet it has remained unclear whether stiffness and EGFR regulate proliferation through common or independent signaling mechanisms. Here we test the hypothesis that microenvironmental stiffness regulates cell cycle progression and proliferation in GBM tumor cells by altering EGFR-dependent signaling. We began by performing an unbiased reverse phase protein array screen, which revealed that stiffness modulates expression and phosphorylation of a broad range of signals relevant to proliferation, including members of the EGFR pathway. We subsequently found that culturing human GBM tumor cells on progressively stiffer culture substrates both dramatically increases proliferation and facilitates passage through the G1/S checkpoint of the cell cycle, consistent with an EGFR-dependent process. Western Blots showed that increasing microenvironmental stiffness enhances the expression and phosphorylation of EGFR and its downstream effector Akt. Pharmacological loss-of-function studies revealed that the stiffness-sensitivity of proliferation is strongly blunted by inhibition of EGFR, Akt, or PI3 kinase. Finally, we observed that stiffness strongly regulates EGFR clustering, with phosphorylated EGFR condensing into vinculin-positive focal adhesions on stiff substrates and dispersing as microenvironmental stiffness falls to physiological levels. Our findings collectively support a model in which tissue stiffening promotes GBM proliferation by spatially and biochemically amplifying EGFR signaling.
Vascular Aging and Arterial Stiffness.
Mikael, Luana de Rezende; Paiva, Anelise Machado Gomes de; Gomes, Marco Mota; Sousa, Ana Luiza Lima; Jardim, Paulo César Brandão Veiga; Vitorino, Priscila Valverde de Oliveira; Euzébio, Maicon Borges; Sousa, Wátila de Moura; Barroso, Weimar Kunz Sebba
2017-06-29
Cardiovascular diseases (CVD) account annually for almost one third of all deaths worldwide. Among the CVD, systemic arterial hypertension (SAH) is related to more than half of those outcomes. Type 2 diabetes mellitus is an independent risk factor for SAH because it causes functional and structural damage to the arterial wall, leading to stiffness. Several studies have related oxidative stress, production of free radicals, and neuroendocrine and genetic changes to the physiopathogenesis of vascular aging. Indirect ways to analyze that aging process have been widely studied, pulse wave velocity (PWV) being considered gold standard to assess arterial stiffness, because there is large epidemiological evidence of its predictive value for cardiovascular events, and it requires little technical knowledge to be performed. A pulse wave is generated during each cardiac contraction and travels along the arterial bed until finding peripheral resistance or any bifurcation point, determining the appearance of a reflected wave. In young individuals, arteries tend to be more elastic, therefore, the reflected wave occurs later in the cardiac cycle, reaching the heart during diastole. In older individuals, however, the reflected wave occurs earlier, reaching the heart during systole. Because PWV is an important biomarker of vascular damage, highly valuable in determining the patient's global cardiovascular risk, we chose to review the articles on vascular aging in the context of cardiovascular risk factors and the tools available to the early identification of that damage. Resumo As doenças cardiovasculares são anualmente responsáveis por quase um terço do total de mortes no mundo. Dentre elas, a hipertensão arterial sistêmica (HAS) está relacionada com mais da metade desses desfechos. O diabetes mellitus tipo 2 é visto com um fator de risco independente para HAS por causar lesões funcionais e estruturais na parede arterial, ocasionando-lhe enrijecimento. Diversos estudos
Stiff Neck, Torticollis, and Pseudotumor Cerebri
J Gordon Millichap
2002-05-01
Full Text Available Three prepubertal children diagnosed with pseudotumor cerebri and presenting with stiff neck and torticollis are reported from Schneider Children’s Medical Center, Sackler School of Medicine, Tel Aviv, Israel.
Observed variations of monopile foundation stiffness
Kallehave, Dan; Thilsted, C.L.; Diaz, Alberto Troya
2015-01-01
The soil-structure stiffness of monopile foundations for offshore wind turbines has a high impact on the fatigue loading during normal operating conditions. Thus, a robust design must consider the evolution of pile-soil stiffness over the lifetime of the wind farm. This paper present and discuss...... full-scale measurements obtained from one offshore wind turbine structure located within Horns Reef II offshore wind farm. Data are presented for a 2.5 years period and covers normal operating conditions and one larger storm event. A reduction of the pile-soil stiffness was observed during the storm...... events, followed by a complete regain to a pre-storm level when the storm subsided. In additional, no long term variations of the pile-soil stiffness was observed. The wind turbine is located in dense to very dense sand deposits....
Strength and stiffness of engineering systems
Leckie, Frederick A
2009-01-01
This book on the stiffness and strength of engineering systems integrates a wide array of topics into a unified text, including plasticity, fracture, composite materials, energy approaches, and mechanics of microdevices (MEMs)..
Vascular Stiffness in Insulin Resistance and Obesity
Guanghong eJia
2015-08-01
Full Text Available Obesity, insulin resistance, and type 2 diabetes are associated with a substantially increased prevalence of vascular fibrosis and stiffness, with attendant increased risk of cardiovascular and chronic kidney disease. Although the underlying mechanisms and mediators of vascular stiffness are not well understood, accumulating evidence supports the role of metabolic and immune dysregulation related to increased adiposity, activation of the renin angiotensin aldosterone system, reduced bioavailable nitric oxide, increased vascular extracellular matrix (ECM and ECM remodeling in the pathogenesis of vascular stiffness. This review will give a brief overview of the relationship between obesity, insulin resistance and increased vascular stiffness to provide a contemporary understanding of the proposed underlying mechanisms and potential therapeutic strategies.
Stiff person syndrome and myasthenia gravis.
Saravanan P
2002-01-01
Full Text Available Association of stiff person syndrome, an immune related disorder of anterior horn cells and myasthenia gravis an endplate disorder with similar pathogenesis, is rare. This communication documents this association in the Indian literature for the first time.
Determination of 6 stiffnesses for a press
Arentoft, Mogens; Eriksen, Morten; Wanheim, Tarras
2000-01-01
The industry is increasingly demanding for better tolerances at cold forged products caused by the tough competition at the market. Near net-shape or net-shape production save resources for machining and reduce therefore also the material costs. During the forming process, the reaction forces fro...... in which the press has the highest stiffness. Furthermore, knowledge about the stiffnesses of all presses in a production system makes it possible to choose the press which best fit to a specific process....... is known too, the final dimensions can be predicted by divide the force by the stiffness and add the clearance. If the stiffness of the press is known, it is possible to optimize the orientation of the workpiece too, so the direction, in which the best tolerances is demanded, is equal to the direction...
Yanwei Guan
2016-07-01
Full Text Available In this paper, a stiffness match method is proposed to reduce the vibration sensitivity of micromachined tuning fork gyroscopes. Taking advantage of the coordinate transformation method, a theoretical model is established to analyze the anti-phase vibration output caused by the stiffness mismatch due to the fabrication imperfections. The analytical solutions demonstrate that the stiffness mismatch is proportional to the output induced by the external linear vibration from the sense direction in the anti-phase mode frequency. In order to verify the proposed stiffness match method, a tuning fork gyroscope (TFG with the stiffness match electrodes is designed and implemented using the micromachining technology and the experimental study is carried out. The experimental tests illustrate that the vibration output can be reduced by 73.8% through the stiffness match method than the structure without the stiffness match. Therefore, the proposed stiffness match method is experimentally validated to be applicable to vibration sensitivity reduction in the Micro-Electro-Mechanical-Systems (MEMS tuning fork gyroscopes without sacrificing the scale factor.
Guan, Yanwei; Gao, Shiqiao; Liu, Haipeng; Jin, Lei; Zhang, Yaping
2016-07-22
In this paper, a stiffness match method is proposed to reduce the vibration sensitivity of micromachined tuning fork gyroscopes. Taking advantage of the coordinate transformation method, a theoretical model is established to analyze the anti-phase vibration output caused by the stiffness mismatch due to the fabrication imperfections. The analytical solutions demonstrate that the stiffness mismatch is proportional to the output induced by the external linear vibration from the sense direction in the anti-phase mode frequency. In order to verify the proposed stiffness match method, a tuning fork gyroscope (TFG) with the stiffness match electrodes is designed and implemented using the micromachining technology and the experimental study is carried out. The experimental tests illustrate that the vibration output can be reduced by 73.8% through the stiffness match method than the structure without the stiffness match. Therefore, the proposed stiffness match method is experimentally validated to be applicable to vibration sensitivity reduction in the Micro-Electro-Mechanical-Systems (MEMS) tuning fork gyroscopes without sacrificing the scale factor.
Guan, Yanwei; Gao, Shiqiao; Liu, Haipeng; Jin, Lei; Zhang, Yaping
2016-01-01
In this paper, a stiffness match method is proposed to reduce the vibration sensitivity of micromachined tuning fork gyroscopes. Taking advantage of the coordinate transformation method, a theoretical model is established to analyze the anti-phase vibration output caused by the stiffness mismatch due to the fabrication imperfections. The analytical solutions demonstrate that the stiffness mismatch is proportional to the output induced by the external linear vibration from the sense direction in the anti-phase mode frequency. In order to verify the proposed stiffness match method, a tuning fork gyroscope (TFG) with the stiffness match electrodes is designed and implemented using the micromachining technology and the experimental study is carried out. The experimental tests illustrate that the vibration output can be reduced by 73.8% through the stiffness match method than the structure without the stiffness match. Therefore, the proposed stiffness match method is experimentally validated to be applicable to vibration sensitivity reduction in the Micro-Electro-Mechanical-Systems (MEMS) tuning fork gyroscopes without sacrificing the scale factor. PMID:27455272
Weakly circadian cells improve resynchrony.
Alexis B Webb
Full Text Available The mammalian suprachiasmatic nuclei (SCN contain thousands of neurons capable of generating near 24-h rhythms. When isolated from their network, SCN neurons exhibit a range of oscillatory phenotypes: sustained or damping oscillations, or arrhythmic patterns. The implications of this variability are unknown. Experimentally, we found that cells within SCN explants recover from pharmacologically-induced desynchrony by re-establishing rhythmicity and synchrony in waves, independent of their intrinsic circadian period We therefore hypothesized that a cell's location within the network may also critically determine its resynchronization. To test this, we employed a deterministic, mechanistic model of circadian oscillators where we could independently control cell-intrinsic and network-connectivity parameters. We found that small changes in key parameters produced the full range of oscillatory phenotypes seen in biological cells, including similar distributions of period, amplitude and ability to cycle. The model also predicted that weaker oscillators could adjust their phase more readily than stronger oscillators. Using these model cells we explored potential biological consequences of their number and placement within the network. We found that the population synchronized to a higher degree when weak oscillators were at highly connected nodes within the network. A mathematically independent phase-amplitude model reproduced these findings. Thus, small differences in cell-intrinsic parameters contribute to large changes in the oscillatory ability of a cell, but the location of weak oscillators within the network also critically shapes the degree of synchronization for the population.
Wang, Shao-Teng; Yang, Hua; Gao, Wen; Li, Hui-Jun; Li, Ping
2016-02-05
The analysis of trace constituents in herbal medicines has always been a challenge due to complex matrices and structural diversities. In this work, a pH-sensitive solid phase extraction (SPE) procedure capable of enriching trace polyphenols in Bistort Rhizoma (BR) was proposed and preliminary chemical characterization was accomplished by high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-QTOF MS). A weak anion-exchange SPE column packed with divinylbenzene/vinylpyrrolidone bonding quaternary amine group was employed for anionic extraction, and the target fraction was obtained by eluting with acidic methanol (apparent pH 1.9). On the other hand, the MS/MS fragmentation rules of four reference polyphenols in negative ion mode were outlined. Using these rules, a total of 31 polyphenols including 20 benzoyl derivatives and 11 caffeoyl derivatives were screened out from BR extract, of which 26 trace members were found for the first time in this herb. Those findings demonstrated that the anion-exchange SPE could enhance the detection capability and selectivity for plant polyphenols in the LC-MS analysis and the strategy for deducing structures could be applied for analysis of polyphenols in BR and other herbal medicines.
Numerical assessment of the stiffness index.
Epstein, Sally; Vergnaud, Anne-Claire; Elliott, Paul; Chowienczyk, Phil; Alastruey, Jordi
2014-01-01
Elevated systemic vascular stiffness is associated with increased risk of cardiovascular disease. It has been suggested that the time difference between the two characteristic peaks of the digital volume pulse (DVP) measured at the finger using photoplethysmography is related to the stiffness of the arterial tree, and inversely proportional to the stiffness index (SI). However, the precise physical meaning of the SI and its relation to aortic pulse wave velocity (aPWV) is yet to be ascertained. In this study we investigated numerically the effect of changes in arterial wall stiffness, peripheral resistances, peripheral compliances or peripheral wave reflections on the SI and aPWV. The SI was calculated from the digital area waveform simulated using a nonlinear one-dimensional model of pulse wave propagation in a 75-artery network, which includes the larger arteries of the hand. Our results show that aPWV is affected by changes in aortic stiffness, but the SI is primarily affected by changes in the stiffness of all conduit vessels. Thus, the SI is not a direct substitute for aPWV. Moreover, our results suggest that peripheral reflections in the upper body delay the time of arrival of the first peak in the DVP. The second peak is predominantly caused by the impedance mismatch within the 75 arterial segments, rather than by peripheral reflections.
Stiffness of Railway Soil-Steel Structures
Machelski, Czesław
2015-12-01
The considerable influence of the soil backfill properties and that of the method of compacting it on the stiffness of soil-steel structures is characteristic of the latter. The above factors (exhibiting randomness) become apparent in shell deformation measurements conducted during construction and proof test loading. A definition of soil-shell structure stiffness, calculated on the basis of shell deflection under the service load, is proposed in the paper. It is demonstrated that the stiffness is the inverse of the deflection influence function used in structural mechanics. The moving load methodology is shown to be useful for testing, since it makes it possible to map the shell deflection influence line also in the case of group loads (concentrated forces), as in bridges. The analyzed cases show that the shell's span, geometry (static scheme) and the height of earth fill influence the stiffness of the structure. The soil-steel structure's characteristic parameter in the form of stiffness k is more suitable for assessing the quality of construction works than the proposed in code geometric index ω applied to beam structures. As shown in the given examples, parameter k is more effective than stiffness parameter λ used to estimate the deformation of soil-steel structures under construction. Although the examples concern railway structures, the methodology proposed in the paper is suitable also for road bridges.
Autoresonance versus localization in weakly coupled oscillators
Kovaleva, Agnessa; Manevitch, Leonid I.
2016-04-01
We study formation of autoresonance (AR) in a two-degree of freedom oscillator array including a nonlinear (Duffing) oscillator (the actuator) weakly coupled to a linear attachment. Two classes of systems are studied. In the first class of systems, a periodic force with constant (resonance) frequency is applied to a nonlinear oscillator (actuator) with slowly time-decreasing stiffness. In the systems of the second class a nonlinear time-invariant oscillator is subjected to an excitation with slowly increasing frequency. In both cases, the attached linear oscillator and linear coupling are time-invariant, and the system is initially engaged in resonance. This paper demonstrates that in the systems of the first type AR in the nonlinear actuator entails oscillations with growing amplitudes in the linear attachment while in the system of the second type energy transfer from the nonlinear actuator is insufficient to excite high-energy oscillations of the attachment. It is also shown that a slow change of stiffness may enhance the response of the actuator and make it sufficient to support oscillations with growing energy in the attachment even beyond the linear resonance. Explicit asymptotic approximations of the solutions are obtained. Close proximity of the derived approximations to exact (numerical) results is demonstrated.
Webb, Muriel; Shibolet, Oren; Halpern, Zamir; Nagar, Meital; Amariglio, Ninette; Levit, Stella; Steinberg, David M; Santo, Erwin; Salomon, Ophira
2015-09-01
Liver stiffness and spleen stiffness in patients with myelofibrosis have traditionally been assessed through manual palpation and thus influenced by interobserver variability. In this article, for the first time, liver stiffness and spleen stiffness of patients with myelofibrosis were evaluated through FibroScan and shear wave elastography (SWE). Nine patients with myelofibrosis comprised the study group. They were compared with 11 patients with liver cirrhosis and 8 healthy volunteers. Before the FibroScan study, all patients underwent ultrasound study to delineate the left intercostal space for validated measurements. In patients with myelofibrosis, the mean stiffness of the spleen was 41.3 and 32.9 kilopascals (kPa) through FibroScan and SWE, respectively. The mean stiffness of the liver was 7.8 kPa through FibroScan and 10.4 kPa through SWE. The stiffness of the spleen in patients with cirrhosis was even higher, reaching a mean of 58.5 kPa through FibroScan and 40.5 kPa through SWE. The means were considerably lower among the healthy controls (13.5 and 18.1 kPa, respectively). The correlation between spleen stiffness among the patients with cirrhosis is negative and opposite in direction (r = -0.35) in comparison with the patients with myelofibrosis (r = 0.78). Among the patients with liver cirrhosis and myelofibrosis, spleen size was weakly related to spleen stiffness as assessed through SWE (r = 0.49) but had almost no relation to the FibroScan measure (r = 0.13). The FibroScan and SWE of the spleen have little ability to distinguish between the patients with myelofibrosis and cirrhosis, but they do differentiate both patient groups from the healthy controls. The stiffness of spleen and liver as measured through FibroScan and SWE was not correlated to the longevity of myelofibrosis.
Aortic stiffness in patients with cardiac syndrome X.
Gorgulu, Sevket; Uslu, Nevzat; Eren, Mehmet; Celik, Seden; Yildirim, Aydin; Dagdeviren, Bahadir; Tezel, Tuna
2003-12-01
Recently, the close relationship between aortic stiffness and cardiovascular mortality has aroused the interest of investigators in carrying out studies related to aortic stiffness. This study aims to investigate the aortic stiffness parameters in patients with cardiac syndrome X, a disorder that is believed to be a generalized disturbance of the vasodilator function of small arteries. 18 patients with typical chest pain and angiographically normal coronary arteries associated with a positive exercise test were included in the study. The control group consisted of 27 patients with angiographically normal coronary arteries and no ischaemia on exercise testing. Antianginal medication was withheld 4 weeks before the study and transthoracic echocardiography was performed using a Hewlett-Packard Sonos 1500 instrument with a 2.5 MHz phased array transducer. Ascending aorta diameters were measured on the M-mode tracing at a level 3 cm above the aortic valve. Diameter change, pulse pressure, aortic strain and distensibility were measured as aortic stiffness parameters. The aortic diameter change was less in the syndrome X group than in the control group (0.15 +/- 0.04 cm/m2 vs. 0.28 +/- 0.12 cm/m2, p < 0.001). Likewise, aortic strain (9 +/- 3% vs. 18 +/- 8%, p < 0.001) and distensibility (4.01 +/- 1.71 cm2 x dyn(-1) x 10(-3) vs. 9.95 +/- 5.08 cm2 x dyn(-1) x 10(-3), p < 0.001) was significantly lower in the syndrome X group than in the control group. The deterioration in aortic elasticity properties in patients with cardiac syndrome X suggests that this disease may be a more generalized disturbance of the vasculature.
A heroin addict with focal weakness.
Galassi, Giuliana; Ariatti, Alessandra; Gozzi, Manuela; Cavazza, Stefano
2013-05-01
A 24-year-old female with 5 year history of heroin abuse experienced painless stiffness of elbow joints and weakness of shoulder and upper limb muscles. She was injecting herself 4-6 times daily alternatively in the upper extremities, sparing the lower limbs. Electromyography (EMG) showed myopathic changes in clinically affected and unaffected muscles. Magnetic resonance imaging (MRI) revealed muscle fibrosis in directly injected muscles, whereas in subcutaneous fat and within muscles of anterior and posterior compartments of both thighs, not directly injected, there were signal changes supportive of oedema and inflammation. EMG and MRI were congruent in showing abnormalities in muscles not directly injected, suggesting long distant effects of heroin or adulterants with a mechanism either toxic or immunologically mediated.
WEAK CONVERGENCE OF SOME SERIES
2000-01-01
This paper continues the study of [1] on weak functions.The weak convergence theory is investigated in complex analysis,Fourier transform and Mellin transform.A Mobius inverse formula of weak functions is obtained.
Kohlenbach, Ulrich Wilhelm
2002-01-01
We show that the so-called weak Markov's principle (WMP) which states that every pseudo-positive real number is positive is underivable in E-HA + AC. Since allows one to formalize (atl eastl arge parts of) Bishop's constructive mathematics, this makes it unlikely that WMP can be proved within the...
On closed weak supplemented modules
ZENG Qing-yi; SHI Mei-hua
2006-01-01
A module M is called closed weak supplemented if for any closed submodule N of M, there is a submodule K of M such that M=K+N and K(c)N＜＜M. Any direct summand of closed weak supplemented module is also closed weak supplemented.Any nonsingular image of closed weak supplemented module is closed weak supplemented. Nonsingular V-rings in which all nonsingular modules are closed weak supplemented are characterized in Section 4.
Psychometric Testing of the Gordon Facial Muscle Weakness Assessment Tool
Gordon, Shirley C.; Blum, Cynthia Ann; Parcells, Dax Andrew
2010-01-01
School nurses may be the first health professionals to assess the onset of facial paralysis/muscle weakness in school-age children. The purpose of this study was to test the psychometric properties of the Gordon Facial Muscle Weakness Assessment Tool (GFMWT) developed by Gordon. Data were collected in two phases. In Phase 1, 4 content experts…
Effects of experimentally increased trunk stiffness on thorax and pelvis rotations during walking.
Wu, Wen Hua; Lin, Xiao Cong; Meijer, Onno G; Gao, Jin Tuan; Hu, Hai; Prins, Maarten R; Liang, Bo Wei; Zhang, Li Qun; Van Dieën, Jaap H; Bruijn, Sjoerd M
2014-02-01
Patients with non-specific low back pain, or a similar disorder, may stiffen their trunk, which probably alters their walking coordination. To study the direct effects of increasing trunk stiffness, we experimentally increased trunk stiffness during walking, and compared the results with what is known from the literature about gait coordination with, e.g., low back pain. Healthy subjects walked on a treadmill at 3 speeds (0.5, 1.0 and 1.5m/s), in three conditions (normal, while contracting their abdominal muscles, or wearing an orthopedic brace that limits trunk motions). Kinematics of the legs, thorax and pelvis were recorded, and relative Fourier phases and amplitudes of segment motions were calculated. Increasing trunk stiffness led to a lower thorax-pelvis relative phase, with both a decrease in thorax-leg relative phase, and an increase in pelvis-leg relative phase, as well as reduced rotational amplitude of thorax relative to pelvis. While lower thorax-pelvis relative phase was also found in patients with low back pain, higher pelvis-leg relative phase has never been reported in patients with low back pain or related disorders. These results suggest that increasing trunk stiffness in healthy subjects causes short-term gait coordination changes which are different from those seen in patients with back pain. Copyright © 2013 Elsevier B.V. All rights reserved.
van Sloten, Thomas T; Protogerou, Athanase D; Henry, Ronald MA; Schram, Miranda T; Launer, Lenore J; Stehouwer, Coen DA
2017-01-01
Arterial stiffness may be a cause of cerebral small vessel disease and cognitive impairment. We therefore performed a systematic review and meta-analysis of studies on the association between stiffness, cerebral small vessel disease and cognitive impairment. For the associations between stiffness (i.e. carotid-femoral pulse wave velocity (cfPWV), brachial-ankle PWV (baPWV), carotid stiffness and pulse pressure) on the one hand and cerebral small vessel disease and cognitive impairment on the other, we identified 23 (n=15,666/22 cross-sectional/3 longitudinal) and 41 studies (n=57,671/30 cross-sectional/15 longitudinal), respectively. Pooled analyses of cross-sectional studies showed that greater stiffness was associated with markers of cerebral small vessel disease with odds ratios, per +1 SD, of 1.29 to 1.32 (P<.001). Studies on cognitive impairment could not be pooled due to large heterogeneity. Some (but not all) studies showed an association between greater stiffness and cognitive impairment, and the strength of this association was relatively weak. The present study supports the hypothesis that greater arterial stiffness is a contributor to microvascular brain disease. PMID:25827412
The stable stiffness triangle - drained sand during deformation cycles
Sabaliauskas, Tomas; Ibsen, Lars Bo
2017-01-01
Cyclic, drained sand stiffness was observed using the Danish triaxial appa- ratus. New, deformation dependant soil property (the stable stiffness triangle) was detected. Using the the stable stiffness triangle, secant stiffness of drained sand was plausible to predict (and control) even during ir...
The Effect of Rib Shape on Stiffness.
Holcombe, Sven A; Wang, Stewart C; Grotberg, James B
2016-11-01
This study investigates the isolated effect of rib shape on the mechanical characteristics of ribs subjected to multiple forms of loading. It aims to measure the variation in stiffness due to shape that is seen throughout the population and, in particular, provide a tool for researchers to better understand the influence of shape on resulting stiffness. A previously published six-parameter shape model of the central axis of human ribs was used. It has been shown to accurately model the overall rib path using intrinsic geometric properties such as size, aspect ratio, and skewness, through shapes based on logarithmic spirals with high curvature continuity. In this study the model was fitted to 19,500 ribs from 989 adult female and male CT scans having demographic distributions matching the US adult population. Mechanical loading was simulated through a simplified finite element model aimed at isolating rib shape from other factors influencing mechanical response. Four loading scenarios were used representing idealized free and constrained loading conditions in axial (body-anterior) and lateral directions. Characteristic rib stiffness and maximum stress location were tracked as simulation output measures. Regression models of rib stiffness found that all shape model parameters added information when predicting stiffness under each loading condition, with their linear combination able to account for 95% of the population stiffness variation due to shape in midlevel ribs for free axial loading, and 92%-98% in other conditions. Full regression models including interactive terms explained up to 99% of population variability. Results allow researchers to better evaluate the differences in stiffness results that are obtained from physical testing by providing a framework with which to explain variation due to rib shape.
Physical inactivity and arterial stiffness in COPD
Sievi NA
2015-09-01
Full Text Available Noriane A Sievi,1 Daniel Franzen,1 Malcolm Kohler,1,2 Christian F Clarenbach1 1Division of Pulmonology, University Hospital of Zurich, 2Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland Background: Arterial stiffness is an important predictor of cardiovascular risk besides classic cardiovascular risk factors. Previous studies showed that arterial stiffness is increased in patients with COPD compared to healthy controls and exercise training may reduce arterial stiffness. Since physical inactivity is frequently observed in patients with COPD and exercise training may improve arterial stiffness, we hypothesized that low daily physical activity may be associated with increased arterial stiffness. Methods: In 123 patients with COPD (72% men; mean [standard deviation] age: 62 [7.5] years; median [quartile] forced expiratory volume in 1 second 35 [27/65] %predicted, arterial stiffness was assessed by augmentation index (AI. Daily physical activity level (PAL was measured by an activity monitor (SenseWear Pro™ >1 week. The association between AI and PAL was investigated by univariate and multivariate regression analysis, taking into account disease-specific characteristics and comorbidities. Results: Patients suffered from moderate (35%, severe (32%, and very severe (33% COPD, and 22% were active smokers. Median (quartile PAL was 1.4 (1.3/1.5 and mean (standard deviation AI 26% (9.2%. PAL showed a negative association with AI (B=-9.32, P=0.017 independent of age, sex, blood pressure, and airflow limitation. Conclusion: In COPD patients, a higher PAL seems to favorably influence arterial stiffness and therefore may reduce cardiovascular risk. Clinical Trial Registration: www.ClinicalTrials.gov, NCT01527773 Keywords: activity monitor, airflow limitation, COPD, physical activity level
Waves in geomaterials exhibiting negative stiffness behaviour
Esin, Maxim; Dyskin, Arcady; Pasternak, Elena
2016-04-01
Negative stiffness denotes the type of material behaviour when the force applied to the body decreases the body's deformation increases. Some geomaterials, for instance, rocks, demonstrate behaviour of this type at certain loads: during the compression tests the loading curves exhibit descending branch (post-peak softening). One of the possible mechanisms of the negative stiffness appearance in geomaterials is rotation of non-spherical grains. It is important to emphasize that in this case the descending branch may be reversible given that the testing machine is stiff enough (in general case it means an importance of boundary conditions). Existence of geomaterials with a negative modulus associated with rotations may have significant importance. In particular, important is understanding of the wave propagation in such materials. We study the stability of geomaterials with negative stiffness inclusions and wave propagation in it using two approaches: Cosserat continuum and discrete mass-spring models. In both cases we consider the rotational degrees of freedom in addition to the conventional translational ones. We show that despite non positiveness of the energy the materials with negative stiffness elements can be stable if certain conditions are met. In the case of Cosserat continuum the Cosserat shear modulus (the modulus relating the non-symmetrical part of shear stress and internal rotations) is allowed to assume negative values as long as its value does not exceed the value of the standard (positive) shear modulus. In the case of discrete mass-spring systems (with translational and rotational springs) the concentration of negative stiffness springs and the absolute values of negative spring stiffness are limited. The critical concentration when the system loses stability and the amplitude of the oscillations tends to infinity is equal to 1/2 and 3/5 for two- and three-dimensional cases respectively.
Weak crystallization theory of metallic alloys
Martin, Ivar; Gopalakrishnan, Sarang; Demler, Eugene A.
2016-06-01
Crystallization is one of the most familiar, but hardest to analyze, phase transitions. The principal reason is that crystallization typically occurs via a strongly first-order phase transition, and thus rigorous treatment would require comparing energies of an infinite number of possible crystalline states with the energy of liquid. A great simplification occurs when crystallization transition happens to be weakly first order. In this case, weak crystallization theory, based on unbiased Ginzburg-Landau expansion, can be applied. Even beyond its strict range of validity, it has been a useful qualitative tool for understanding crystallization. In its standard form, however, weak crystallization theory cannot explain the existence of a majority of observed crystalline and quasicrystalline states. Here we extend the weak crystallization theory to the case of metallic alloys. We identify a singular effect of itinerant electrons on the form of weak crystallization free energy. It is geometric in nature, generating strong dependence of free energy on the angles between ordering wave vectors of ionic density. That leads to stabilization of fcc, rhombohedral, and icosahedral quasicrystalline (iQC) phases, which are absent in the generic theory with only local interactions. As an application, we find the condition for stability of iQC that is consistent with the Hume-Rothery rules known empirically for the majority of stable iQC; namely, the length of the primary Bragg-peak wave vector is approximately equal to the diameter of the Fermi sphere.
Variable stiffness design of redundantly actuated planar rotational parallel mechanisms
Li Kangkang; Jiang Hongzhou; Cui Zuo; Huang Qun
2017-01-01
Redundantly actuated planar rotational parallel mechanisms (RAPRPMs) adapt to the requirements of robots under different working conditions by changing the antagonistic internal force to tune their stiffness. The geometrical parameters of the mechanism impact the performances of modulating stiffness. Analytical expressions relating stiffness and geometrical parameters of the mechanism were formulated to obtain the necessary conditions of variable stiffness. A novel method of variable stiffness design was presented to optimize the geometrical parameters of the mechanism. The stiffness variation with the internal force was maximized. The dynamic change of stiffness with the dynamic location of the mechanism was minimized, and the robustness of stiff-ness during the motion of the mechanism was ensured. This new approach to variable stiffness design can enable off-line planning of the internal force to avoid the difficulties of on-line control of the internal force.
Nonlinear model of space manipulator joint considering time-variant stiffness and backlash
Yang, Tianfu; Yan, Shaoze; Han, Zengyao
2015-04-01
Modeling of space manipulator joints has been studied for years but accurate positioning control is still unsatisfactory. One of the primary reasons is that, in the past researches, effects of the high-ratio reducers in the joints have usually been neglected. In this paper, a nonlinear dynamic model of the manipulator joint with planetary gear train transmission is developed by considering time-variant joint stiffness, backlash and reduction ratio. Based on the gear parameters and meshing phase relationship, the stiffness of the joint model is presented, in which the time-variant stiffness of 2K-H planetary gear train and the backlash are taken into consideration. The backlash effect is modeled as an alternate engagement mechanism, and the transmitted torque is defined as a dead zone function. This model is simulated on a two-link space manipulator system. The results show that the time-variant stiffness effect can be simplified as a constant value in most cases when other shafting parts are flexible, while if the total stiffness is approximate to the nonlinear stiffness, the positioning accuracy is reduced if neglecting the time-variant part. On the other hand, the backlash is the main source of positioning error and impact. Minimizing backlash is the most effective way to improve positioning accuracy and avoid the impact in the gearing system.
McGee, K P; Lake, D; Mariappan, Y; Manduca, A; Ehman, R L [Department of Radiology, Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN 55905 (United States); Hubmayr, R D [Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN 55905 (United States); Ansell, K, E-mail: mcgee.kiaran@mayo.edu [Schaeffer Academy, 2700 Schaeffer Lane NE, Rochester, MN 55906 (United States)
2011-07-21
Magnetic resonance elastography (MRE) is a non-invasive phase-contrast-based method for quantifying the shear stiffness of biological tissues. Synchronous application of a shear wave source and motion encoding gradient waveforms within the MRE pulse sequence enable visualization of the propagating shear wave throughout the medium under investigation. Encoded shear wave-induced displacements are then processed to calculate the local shear stiffness of each voxel. An important consideration in local shear stiffness estimates is that the algorithms employed typically calculate shear stiffness using relatively high signal-to-noise ratio (SNR) MRE images and have difficulties at an extremely low SNR. A new method of estimating shear stiffness based on the principal spatial frequency of the shear wave displacement map is presented. Finite element simulations were performed to assess the relative insensitivity of this approach to decreases in SNR. Additionally, ex vivo experiments were conducted on normal rat lungs to assess the robustness of this approach in low SNR biological tissue. Simulation and experimental results indicate that calculation of shear stiffness by the principal frequency method is less sensitive to extremely low SNR than previously reported MRE inversion methods but at the expense of loss of spatial information within the region of interest from which the principal frequency estimate is derived.
Weak Polarized Electron Scattering
Erler, Jens; Mantry, Sonny; Souder, Paul A
2014-01-01
Scattering polarized electrons provides an important probe of the weak interactions. Precisely measuring the parity-violating left-right cross section asymmetry is the goal of a number of experiments recently completed or in progress. The experiments are challenging, since A_{LR} is small, typically between 10^(-4) and 10^(-8). By carefully choosing appropriate targets and kinematics, various pieces of the weak Lagrangian can be isolated, providing a search for physics beyond the Standard Model. For other choices, unique features of the strong interaction are studied, including the radius of the neutron density in heavy nuclei, charge symmetry violation, and higher twist terms. This article reviews the theory behind the experiments, as well as the general techniques used in the experimental program.
Groothuis, S.S.; Carloni, R.; Stramigioli, S.
2016-01-01
This paper presents a proof of concept of a variable stiffness actuator (VSA) that uses only one (high power) input motor. In general, VSAs use two (high power) motors to be able to control both the output position and the output stiffness, which possibly results in a heavy, and bulky system. In thi
Suzuki, M.
1988-04-01
Dynamical mechanism of composite W and Z is studied in a 1/N field theory model with four-fermion interactions in which global weak SU(2) symmetry is broken explicitly by electromagnetic interaction. Issues involved in such a model are discussed in detail. Deviation from gauge coupling due to compositeness and higher order loop corrections are examined to show that this class of models are consistent not only theoretically but also experimentally.
Biomarkers of Hemodynamic Stress and Aortic Stiffness after STEMI: A Cross-Sectional Analysis
Sebastian Johannes Reinstadler
2015-01-01
Full Text Available Aim. Increased aortic stiffness might adversely affect cardiac structure, function, and perfusion. Release of biomarkers of hemodynamic stress is thought to be enhanced by these alterations. We aimed to evaluate the association between biomarkers of hemodynamic stress and aortic stiffness assessed at a chronic stage after ST-segment elevation myocardial infarction (STEMI. Methods. Fifty-four patients four months after STEMI were enrolled in this cross-sectional, single-center study. N-terminal pro–B-type natriuretic peptide (NT-proBNP, mid-regional pro–A-type natriuretic peptide (MR-proANP, and mid-regional proadrenomedullin (MR-proADM levels were measured by established assays. Aortic stiffness was assessed by the measurement of pulse wave velocity using phase-contrast cardiovascular magnetic resonance. Results. NT-proBNP, MR-proANP, and MR-proADM concentrations were all correlated with aortic stiffness in univariate analysis (r=0.378, r=0.425, and r=0.532; all P<0.005, resp.. In multiple linear regression analysis, NT-proBNP (β=0.316, P=0.005 and MR-proADM (β=0.284, P<0.020 levels were associated with increased aortic stiffness independently of age, blood pressure, and renal function. NT-proBNP was the strongest predictor for high aortic stiffness (area under the curve: 0.82, 95% CI 0.67–0.96. Conclusion. At a chronic stage after STEMI, concentrations of biomarkers for hemodynamic stress, especially NT-proBNP, are positively correlated with aortic stiffness. These biomarkers might also be useful as predictors of high aortic stiffness after STEMI.
Revealed Quantum Information in Weak Interaction Processes
Hiesmayr, B C
2014-01-01
We analyze the achievable limits of the quantum information processing of the weak interaction revealed by hyperons with spin. We find that the weak decay process corresponds to an interferometric device with a fixed visibility and fixed phase difference for each hyperon. Nature chooses rather low visibilities expressing a preference to parity conserving or violating processes (except for the decay $\\Sigma^+\\longrightarrow p \\pi^0$). The decay process can be considered as an open quantum channel that carries the information of the hyperon spin to the angular distribution of the momentum of the daughter particles. We find a simple geometrical information theoretic interpretation of this process: two quantization axes are chosen spontaneously with probabilities $\\frac{1\\pm\\alpha}{2}$ where $\\alpha$ is proportional to the visibility times the real part of the phase shift. Differently stated the weak interaction process corresponds to spin measurements with an imperfect Stern-Gerlach apparatus. Equipped with this...
[Stiff-person syndrome and related autoantibodies].
Tomioka, Ryo; Tanaka, Keiko
2013-04-01
Central nervous system hyperexcitability disorders, known as stiff-man/person syndrome (SPS), are thought to be related to the regulatory disturbance of inhibitory synaptic transmission of motor neurons in the brainstem and spinal cord. SPS is characterized by stiffness and spasms of the axis and limbs and is divided into two clinical subgroups: classic SPS, which affects the lumbar, trunk, and proximal limb muscles, and SPS-plus syndrome. The latter comprises (1) the stiff-limb subtype, in which symptom is limited to the lower limbs; (2) jerking stiff-man syndrome, characterized by chronically progressive stiffness and myoclonus; and (3) acute-onset and progressive encephalomyelitis with rigidity and myoclonus. Almost 80% of patients with classic SPS harbor autoantibodies against glutamic acid decarboxylase 65 (GAD65). In approximately 30-40% of patients, SPS accompanies type I diabetes, and anti-GAD65 antibodies are detected frequently in type I diabetes. However, the antibody-recognizing epitopes might be different between SPS and diabetes. Other autoantibodies against glycine receptor α1 (12% of patients with SPS) and GABA(A)-receptor associated protein (70% of patients with SPS) have been reported. In paraneoplastic SPS, anti-amphiphysin antibodies have been shown in patients with breast cancer or small cell lung cancer. One case of mediastinal tumor with anti-gephyrin antibodies has also been reported. However, the roles of these autoantibodies in the pathomechanisms of SPS have not yet been elucidated.
Big Bang nucleosynthesis with a stiff fluid
Dutta, Sourish
2010-01-01
Models that lead to a cosmological stiff fluid component, with a density $\\rho_S$ that scales as $a^{-6}$, where $a$ is the scale factor, have been proposed recently in a variety of contexts. We calculate numerically the effect of such a stiff fluid on the primordial element abundances. Because the stiff fluid energy density decreases with the scale factor more rapidly than radiation, it produces a relatively larger change in the primordial helium-4 abundance than in the other element abundances, relative to the changes produced by an additional radiation component. We show that the helium-4 abundance varies linearly with the density of the stiff fluid at a fixed fiducial temperature. Taking $\\rho_{S10}$ and $\\rho_{R10}$ to be the stiff fluid energy density and the standard density in relativistic particles, respectively, at $T = 10$ MeV, we find that the change in the primordial helium abundance is well-fit by $\\Delta Y_p = 0.00024(\\rho_{S10}/\\rho_{R10})$. The changes in the helium-4 abundance produced by ad...
Torso flexion modulates stiffness and reflex response.
Granata, K P; Rogers, E
2007-08-01
Neuromuscular factors that contribute to spinal stability include trunk stiffness from passive and active tissues as well as active feedback from reflex response in the paraspinal muscles. Trunk flexion postures are a recognized risk factor for occupational low-back pain and may influence these stabilizing control factors. Sixteen healthy adult subjects participated in an experiment to record trunk stiffness and paraspinal muscle reflex gain during voluntary isometric trunk extension exertions. The protocol was designed to achieve trunk flexion without concomitant influences of external gravitational moment, i.e., decouple the effects of trunk flexion posture from trunk moment. Systems identification analyses identified reflex gain by quantifying the relation between applied force disturbances and time-dependent EMG response in the lumbar paraspinal muscles. Trunk stiffness was characterized from a second order model describing the dynamic relation between the force disturbances versus the kinematic response of the torso. Trunk stiffness increased significantly with flexion angle and exertion level. This was attributed to passive tissue contributions to stiffness. Reflex gain declined significantly with trunk flexion angle but increased with exertion level. These trends were attributed to correlated changes in baseline EMG recruitment in the lumbar paraspinal muscles. Female subjects demonstrated greater reflex gain than males and the decline in reflex gain with flexion angle was greater in females than in males. Results reveal that torso flexion influences neuromuscular factors that control spinal stability and suggest that posture may contribute to the risk of instability injury.
Zhao, Miao; Wu, Xiao-Jie; Fan, Ya-Xin; Guo, Bei-Ning; Zhang, Jing
2016-05-30
A rapid ultra high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) assay method was developed for determination of CMS and formed colistin in human plasma and urine. After extraction on a 96-well SPE Supra-Clean Weak Cation Exchange (WCX) plate, the eluents were mixed and injected into the UHPLC-MS/MS system directly. A Phonomenex Kinetex XB-C18 analytical column was employed with a mobile phase consisting of solution "A" (acetonitrile:methanol, 1:1, v/v) and solution "B" (0.1% formic acid in water, v/v). The flow rate was 0.4 mL/min with gradient elution over 3.5 min. Ions were detected in ESI positive ion mode and the precursor-product ion pairs were m/z 390.7/101.3 for colistin A, m/z 386.0/101.2 for colistin B, and m/z 402.3/101.2 for polymyxin B1 (IS), respectively. The lower limit of quantification (LLOQ) was 0.0130 and 0.0251 mg/L for colistin A and colistin B in both plasma and urine with accuracy (relative error, %) <± 12.6% and precision (relative standard deviation, %) <± 10.8%. Stability of CMS was demonstrated in biological samples before and during sample treatment, and in the extract. This new analytical method provides high-throughput treatment and optimized quantification of CMS and colistin, which offers a highly efficient tool for the analysis of a large number of clinical samples as well as routine therapeutic drug monitoring.
Stefan Groothuis
2014-06-01
Full Text Available In this paper, a novel variable stiffness mechanism is presented, which is capable of achieving an output stiffness with infinite range and an unlimited output motion, i.e., the mechanism output is completely decoupled from the rotor motion, in the zero stiffness configuration. The mechanism makes use of leaf springs, which are engaged at different positions by means of two movable supports, to realize the variable output stiffness. The Euler–Bernoulli leaf spring model is derived and validated through experimental data. By shaping the leaf springs, it is shown that the stiffness characteristic of the mechanism can be changed to fulfill different application requirements. Alternative designs can achieve the same behavior with only one leaf spring and one movable support pin.
Robertson, G A J; Coleman, S G S; Keating, J F
2009-08-01
We reviewed 100 patients retrospectively following primary ACL reconstruction with quadruple hamstring autografts to evaluate the incidence and factors associated with postoperative stiffness. Stiffness was defined as any loss of motion using the contra-lateral leg as a control. The median delay between injury and operation was 15 months. The incidence of stiffness was 12% at 6 months post-reconstruction. Both incomplete attendance at physiotherapy (pAnterior knee pain was also associated with the stiffness (p<0.029). Factors that failed to show a significant association with the stiffness included associated MCL sprain at injury (p=0.32), post-injury stiffness (p=1.00) and concomitant menisectomy at reconstruction (p=0.54). Timing of surgery also did not appear to influence the onset of stiffness (median delays: 29 months for stiff patients; 14 months for non-stiff patients). The rate of stiffness fell to 5% at 12 months postreconstruction, without operative intervention.
Khomchenko, V. A., E-mail: uladzimir@fis.uc.pt; Paixão, J. A. [CEMDRX/Department of Physics, University of Coimbra, P-3004-516 Coimbra (Portugal); Pereira, L. C. J. [Unidade de Ciências Químicas e Radiofarmacêuticas, IST/CTN, Instituto Superior Técnico, Universidade Técnica de Lisboa/CFMCUL, P-2686-953 Sacavém (Portugal)
2014-04-28
Crystal structure, microstructure, local ferroelectric, and magnetic properties of the Bi{sub 0.9}Nd{sub 0.1}Fe{sub 1−x}Ti{sub x}O{sub 3} samples have been investigated at room temperature to reveal the effect of Ti{sup 4+} doping on the multiferroic behavior of the lanthanide-modified compound representing a polar (space group R3c) antiferromagnetic phase of the Bi{sub 1−x}Ln{sub x}FeO{sub 3} perovskites. Ti doping results in a gradual suppression of the rhombohedral distortions, however, symmetry of the crystal structure remains the same in the entire concentration range allowing the single-phase perovskites to be obtained (x ≤ 0.08). The doping tends to reduce existing lone-pair cation-driven polar displacements, thus giving rise to a decrease of the ferroelectric polarization in the Bi{sub 0.9}Nd{sub 0.1}Fe{sub 1−x}Ti{sub x}O{sub 3} (x→0.08) series. A drastic (from ∼10 μm for x = 0 to ∼1 μm for 0.02 ≤ x ≤ 0.08) decrease of the average grain size induced by the doping is accompanied by the formation of a ferroelectric domain structure with the average domain width of ∼40 nm. Finally, the doping was shown to induce an antiferromagnetic to weak ferromagnetic transformation. The maximum remanent magnetization observed in the Bi{sub 0.9}Nd{sub 0.1}Fe{sub 1−x}Ti{sub x}O{sub 3} series at x ∼ 0.05 coincides with the locked magnetization releasing upon the magnetic field-induced suppression of the magnetic cycloid in pure BiFeO{sub 3}.
Li, Jiasong; Han, Zhaolong; Singh, Manmohan; Twa, Michael D.; Larin, Kirill V.
2014-11-01
Structurally degenerative diseases, such as keratoconus, can significantly alter the stiffness of the cornea, directly affecting the quality of vision. Ultraviolet-induced collagen cross-linking (CXL) effectively increases corneal stiffness and is applied clinically to treat keratoconus. However, measured corneal stiffness is also influenced by intraocular pressure (IOP). Therefore, experimentally measured changes in corneal stiffness may be attributable to the effects of CXL, changes in IOP, or both. We present a noninvasive measurement method using phase-stabilized swept-source optical coherence elastography to distinguish between CXL and IOP effects on measured corneal stiffness. This method compared the displacement amplitude attenuation of a focused air-pulse-induced elastic wave. The damping speed of the displacement amplitudes at each measurement position along the wave propagation were compared for different materials. This method was initially tested on gelatin and agar phantoms of the same stiffness for validation. Consequently, untreated and CXL-treated porcine corneas of the same measured stiffness, but at different IOPs, were also evaluated. The results suggest that this noninvasive method may have the potential to detect the early stages of ocular diseases such as keratoconus or may be applied during CLX procedures by factoring in the effects of IOP on the measured corneal stiffness.
Haagerup, Uffe; Knudby, Søren
2015-01-01
The weak Haagerup property for locally compact groups and the weak Haagerup constant were recently introduced by the second author [27]. The weak Haagerup property is weaker than both weak amenability introduced by Cowling and the first author [9] and the Haagerup property introduced by Connes [6......] and Choda [5]. In this paper, it is shown that a connected simple Lie group G has the weak Haagerup property if and only if the real rank of G is zero or one. Hence for connected simple Lie groups the weak Haagerup property coincides with weak amenability. Moreover, it turns out that for connected simple...... Lie groups the weak Haagerup constant coincides with the weak amenability constant, although this is not true for locally compact groups in general. It is also shown that the semidirect product R2 × SL(2,R) does not have the weak Haagerup property....
Electrochemical stiffness in lithium-ion batteries
Tavassol, Hadi; Jones, Elizabeth M. C.; Sottos, Nancy R.; Gewirth, Andrew A.
2016-11-01
Although lithium-ion batteries are ubiquitous in portable electronics, increased charge rate and discharge power are required for more demanding applications such as electric vehicles. The high-rate exchange of lithium ions required for more power and faster charging generates significant stresses and strains in the electrodes that ultimately lead to performance degradation. To date, electrochemically induced stresses and strains in battery electrodes have been studied only individually. Here, a new technique is developed to probe the chemomechanical response of electrodes by calculating the electrochemical stiffness via coordinated in situ stress and strain measurements. We show that dramatic changes in electrochemical stiffness occur due to the formation of different graphite-lithium intercalation compounds during cycling. Our analysis reveals that stress scales proportionally with the lithiation/delithiation rate and strain scales proportionally with capacity (and inversely with rate). Electrochemical stiffness measurements provide new insights into the origin of rate-dependent chemomechanical degradation and the evaluation of advanced battery electrodes.
Red wine, arterial stiffness and central hemodynamics.
Karatzi, Kalliopi; Papaioannou, Theodore G; Papamichael, Christos; Lekakis, John; Stefanadis, Christodoulos; Zampelas, Antonis
2009-01-01
Red wine is considered to reduce cardiovascular risk and decrease peripheral systolic and diastolic blood pressure. Central aortic pressures are often more sensitive clinical and prognostic factors than peripheral pressures, while arterial stiffness is an independent prognostic factor for cardiovascular events. Great efforts are being made to find natural sources of improving health. In order to clarify the mechanisms under which a widely used drink, like red wine, is affecting heart and vessels, we aimed to review the available data regarding the effects of red wine on arterial stiffness, wave reflections and central blood pressures. The effect of red wine on central hemodynamics has been poorly explored with divergent results. Possible consequences of acute and long-term intake on arterial stiffness, wave reflections and central pressures are not clear. This might make someone skeptical when suggesting the consumption of a glass of red wine, although its cardioprotective actions (when moderately consumed) are already shown from epidemiological studies.
Dynamic stiffness model of spherical parallel robots
Cammarata, Alessandro; Caliò, Ivo; D`Urso, Domenico; Greco, Annalisa; Lacagnina, Michele; Fichera, Gabriele
2016-12-01
A novel approach to study the elastodynamics of Spherical Parallel Robots is described through an exact dynamic model. Timoshenko arches are used to simulate flexible curved links while the base and mobile platforms are modelled as rigid bodies. Spatial joints are inherently included into the model without Lagrangian multipliers. At first, the equivalent dynamic stiffness matrix of each leg, made up of curved links joined by spatial joints, is derived; then these matrices are assembled to obtain the Global Dynamic Stiffness Matrix of the robot at a given pose. Actuator stiffness is also included into the model to verify its influence on vibrations and modes. The latter are found by applying the Wittrick-Williams algorithm. Finally, numerical simulations and direct comparison to commercial FE results are used to validate the proposed model.
Weak martingale Hardy spaces and weak atomic decompositions
HOU; Youliang; REN; Yanbo
2006-01-01
In this paper we define some weak martingale Hardy spaces and three kinds of weak atoms. They are the counterparts of martingale Hardy spaces and atoms in the classical martingale Hp-theory. And then three atomic decomposition theorems for martingales in weak martingale Hardy spaces are proved. With the help of the weak atomic decompositions of martingale, a sufficient condition for a sublinear operator defined on the weak martingale Hardy spaces to be bounded is given. Using the sufficient condition, we obtain a series of martingale inequalities with respect to the weak Lp-norm, the inequalities of weak (p ,p)-type and some continuous imbedding relationships between various weak martingale Hardy spaces. These inequalities are the weak versions of the basic inequalities in the classical martingale Hp-theory.
Variable stiffness and damping magnetorheological isolator
Yang ZHOU; Xingyu WANG; Xianzhou ZHANG; Weihua LI
2009-01-01
This paper presents the development and characterization of a magnetorheological (MR) fluid-based variable stiffness and damping isolator. The prototype of the MR fluid isolator is fabricated, and its dynamic behavior is measured under various applied magnetic fields. The parameters of the model under various magnetic fields are identified, and the dynamic perfor-mance of the isolator is evaluated in simulation. Experi-mental results indicate that both the stiffness and damping capability of the developed MR isolator can be controlled by an external magnetic field.
Inversion assuming weak scattering
Xenaki, Angeliki; Gerstoft, Peter; Mosegaard, Klaus
2013-01-01
The study of weak scattering from inhomogeneous media or interface roughness has long been of interest in sonar applications. In an acoustic backscattering model of a stationary field of volume inhomogeneities, a stochastic description of the field is more useful than a deterministic description...... due to the complex nature of the field. A method based on linear inversion is employed to infer information about the statistical properties of the scattering field from the obtained cross-spectral matrix. A synthetic example based on an active high-frequency sonar demonstrates that the proposed...
Erler, Jens
2013-01-01
This is a review of electroweak precision physics with particular emphasis on low-energy precision measurements in the neutral current sector of the electroweak theory and includes future experimental prospects and the theoretical challenges one faces to interpret these observables. Within the minimal Standard Model they serve as determinations of the weak mixing angle which are competitive with and complementary to those obtained near the Z-resonance. In the context of new physics beyond the Standard Model these measurements are crucial to discriminate between models and to reduce the allowed parameter space within a given model. We illustrate this for the minimal supersymmetric Standard Model with or without R-parity.
Measurement of weak radioactivity
Theodorsson , P
1996-01-01
This book is intended for scientists engaged in the measurement of weak alpha, beta, and gamma active samples; in health physics, environmental control, nuclear geophysics, tracer work, radiocarbon dating etc. It describes the underlying principles of radiation measurement and the detectors used. It also covers the sources of background, analyzes their effect on the detector and discusses economic ways to reduce the background. The most important types of low-level counting systems and the measurement of some of the more important radioisotopes are described here. In cases where more than one type can be used, the selection of the most suitable system is shown.
Weakly broken galileon symmetry
Pirtskhalava, David [Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126 Pisa (Italy); Santoni, Luca; Trincherini, Enrico [Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126 Pisa (Italy); INFN, Sezione di Pisa, Piazza dei Cavalieri 7, 56126 Pisa (Italy); Vernizzi, Filippo [Institut de Physique Théorique, Université Paris Saclay, CEA, CNRS, Gif-sur-Yvette cédex, F-91191 (France)
2015-09-01
Effective theories of a scalar ϕ invariant under the internal galileon symmetryϕ→ϕ+b{sub μ}x{sup μ} have been extensively studied due to their special theoretical and phenomenological properties. In this paper, we introduce the notion of weakly broken galileon invariance, which characterizes the unique class of couplings of such theories to gravity that maximally retain their defining symmetry. The curved-space remnant of the galileon’s quantum properties allows to construct (quasi) de Sitter backgrounds largely insensitive to loop corrections. We exploit this fact to build novel cosmological models with interesting phenomenology, relevant for both inflation and late-time acceleration of the universe.
Spatial-domain interactions between ultra-weak optical beams
Khadka, Utsab; Xiao, Min
2013-01-01
We have observed the spatial interactions between two ultra-weak optical beams that are initially collinear and non-overlapping. The weak beams are steered towards each other by a spatially varying cross-Kerr refractive index waveguide written by a strong laser beam in a three-level atomic medium utilizing quantum coherence. After being brought together, the weak beams show controllable phase-dependent outcomes. This is the first observation of soliton-like interactions between weak beams and can be useful for all-optically tunable beam-combining, switching and gates for weak photonic signals.
Modulation of fixation stiffness from flexible to stiff in a rat model of bone healing.
Bartnikowski, Nicole; Claes, Lutz E; Koval, Lidia; Glatt, Vaida; Bindl, Ronny; Steck, Roland; Ignatius, Anita; Schuetz, Michael A; Epari, Devakara R
2016-11-14
Background and purpose - Constant fixator stiffness for the duration of healing may not provide suitable mechanical conditions for all stages of bone repair. We therefore investigated the influence of stiffening fixation on callus stiffness and morphology in a rat diaphyseal osteotomy model to determine whether healing time was shortened and callus stiffness increased through modulation of fixation from flexible to stiff. Material and methods - An external unilateral fixator was applied to the osteotomized femur and stiffened by decreasing the offset of the inner fixator bar at 3, 7, 14, and 21 days after operation. After 5 weeks, the rats were killed and healing was evaluated with mechanical, histological, and microcomputed tomography methods. Constant fixation stiffness control groups with either stiff or flexible fixation were included for comparison. Results - The callus stiffness of the stiff group and all 4 experimental groups was greater than in the flexible group. The callus of the flexible group was larger but contained a higher proportion of unmineralized tissue and cartilage. The stiff and modulated groups (3, 7, 14, and 21 days) all showed bony bridging at 5 weeks, as well as signs of callus remodeling. Stiffening fixation at 7 and 14 days after osteotomy produced the highest degree of callus bridging. Bone mineral density in the fracture gap was highest in animals in which the fixation was stiffened after 14 days. Interpretation - The predicted benefit of a large robust callus formed through early flexible fixation could not be shown, but the benefits of stabilizing a flexible construct to achieve timely healing were demonstrated at all time points.
Alberico, W M
2004-01-01
The focus of these Lectures is on the weak decay modes of hypernuclei, with special attention to Lambda-hypernuclei. The subject involves many fields of modern theoretical and experimental physics, from nuclear structure to the fundamental constituents of matter and their interactions. The various weak decay modes of Lambda-hypernuclei are described: the mesonic mode and the non-mesonic ones. The latter are the dominant decay channels of medium--heavy hypernuclei, where, on the contrary, the mesonic decay is disfavoured by Pauli blocking effect on the outgoing nucleon. In particular, one can distinguish between one-body and two-body induced decays. Theoretical models employed to evaluate the (partial and total) decay widths of hypernuclei are illustrated, and their results compared with existing experimental data. Open problems and recent achievements are extensively discussed, in particular the determination of the ratio Gamma_n/Gamma_p, possible tests of the Delta I=1/2 rule in non-mesonic decays and the pu...
Jolley, Sarah E; Bunnell, Aaron E; Hough, Catherine L
2016-11-01
Survivorship after critical illness is an increasingly important health-care concern as ICU use continues to increase while ICU mortality is decreasing. Survivors of critical illness experience marked disability and impairments in physical and cognitive function that persist for years after their initial ICU stay. Newfound impairment is associated with increased health-care costs and use, reductions in health-related quality of life, and prolonged unemployment. Weakness, critical illness neuropathy and/or myopathy, and muscle atrophy are common in patients who are critically ill, with up to 80% of patients admitted to the ICU developing some form of neuromuscular dysfunction. ICU-acquired weakness (ICUAW) is associated with longer durations of mechanical ventilation and hospitalization, along with greater functional impairment for survivors. Although there is increasing recognition of ICUAW as a clinical entity, significant knowledge gaps exist concerning identifying patients at high risk for its development and understanding its role in long-term outcomes after critical illness. This review addresses the epidemiologic and pathophysiologic aspects of ICUAW; highlights the diagnostic challenges associated with its diagnosis in patients who are critically ill; and proposes, to our knowledge, a novel strategy for identifying ICUAW. Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
Improved Quantum Signature Scheme with Weak Arbitrator
Su, Qi; Li, Wen-Min
2013-09-01
In this paper, we find a man-in-the-middle attack on the quantum signature scheme with a weak arbitrator (Luo et al., Int. J. Theor. Phys., 51:2135, 2012). In that scheme, the authors proposed a quantum signature based on quantum one way function which contains both verifying the signer phase and verifying the signed message phase. However, after our analysis we will show that Eve can adopt different strategies in respective phases to forge the signature without being detected. Then we present an improved scheme to increase the security.
Orbai, Ana-Maria; Smith, Katherine C; Bartlett, Susan J; De Leon, Elaine; Bingham, Clifton O
2014-11-01
Stiffness is a well-recognized symptom of rheumatoid arthritis (RA). It is frequently queried during clinic visits as an indicator of disease activity and was included in the 1961 and 1987 RA classification criteria. Little is known about how people with RA experience stiffness and its impact on their lives. We conducted 4 focus groups including 20 people with RA (4-6 participants per group) from 1 academic clinical practice and 1 private practice to generate accounts of stiffness experiences. Qualitative inductive thematic data analysis was conducted. Five overarching themes were identified: relationship of stiffness with other symptoms, exacerbating or alleviating factors and self-management, stiffness timing and location, individual meanings of stiffness experiences, and impact of stiffness on daily life. Focus group discussions revealed individual stiffness experiences as diverse and complex. Several stiffness features were endorsed by a majority of participants, but few, if any, were universally experienced; thus, the significance of stiffness as an expression of the disease varied widely. Discussions yielded descriptions of how individual limits imposed by RA in general and stiffness in particular may change over time and were intertwined with adaptations to preserve participation in valued life activities. These results concerning the diversity of the stiffness experience, consequential adaptations, and its impact suggest that a more individualized approach to stiffness measurement may be needed to improve stiffness assessments. Copyright © 2014 by the American College of Rheumatology.
Plant fibre composites - porosity and stiffness
Madsen, Bo; Thygesen, Anders; Lilholt, Hans
2009-01-01
Plant fibre composites contain typically a relatively large amount of porosity which influences their performance. A model, based on a modified rule of mixtures, is presented to include the influence of porosity on the composite stiffness. The model integrates the volumetric composition of the co......Plant fibre composites contain typically a relatively large amount of porosity which influences their performance. A model, based on a modified rule of mixtures, is presented to include the influence of porosity on the composite stiffness. The model integrates the volumetric composition...... of the composites with their mechanical properties. The fibre weight fraction is used as an independent parameter to calculate the complete volumetric composition. A maximum obtainable stiffness of the composites is calculated at a certain transition fibre weight fraction, which is characterised by a best possible...... combination of high fibre volume fraction and low porosity. The model is validated with experimental data from the literature on several types of composites. A stiffness diagram is presented to demonstrate that the calculations can be used for tailoring and design of composites with a given profile...
[Anaesthetic management of Stiff Man syndrome].
Marín, T; Hernando, D; Kinast, N; Churruca, I; Sabate, S
2015-04-01
Stiff Man syndrome or stiff-person syndrome is a rare autoimmune disorder. It is characterized by increased axial muscular tone and limb musculature, and painful spasms triggered by stimulus. The case is presented of a 44-year-old man with stiff-person syndrome undergoing an injection of botulinum toxin in the urethral sphincter under sedation. Before induction, all the surgical team were ready in order to minimise the anaesthetic time. The patient was monitored by continuous ECG, SpO2 and non-invasive blood pressure. He was induced with fractional dose of propofol 150 mg, fentanyl 50 μg and midazolam 1mg. Despite careful titration, the patient had an O2 saturation level of 90%,which was resolved by manual ventilation. There was no muscle rigidity or spasm during the operation. Post-operative recovery was uneventful and the patient was discharged 2 days later. A review of other cases is presented. The anaesthetic concern in patients with stiff-person syndrome is the interaction between the anaesthetic agents, the preoperative medication, and the GABA system. For a safe anaesthetic management, total intravenous anaesthesia is recommended instead of inhalation anaesthetics, as well as the close monitoring of the respiratory function and the application of the electrical nerve stimulator when neuromuscular blockers are used.
Non-singular inhomogeneous stiff fluid cosmology
Fernández-Jambrina, L
2009-01-01
In this talk we show a stiff fluid solution of the Einstein equations for a cylindrically symmetric spacetime. The main features of this metric are that it is non-separable in comoving coordinates for the congruence of the worldlineS of the fluid and that it yields regular curvature invariants.
Monitoring the Bending Stiffness of DNA
Yuan, Chongli; Lou, Xiongwen; Rhoades, Elizabeth; Chen, Huimin; Archer, Lynden
2007-03-01
In eukaryotic cells, the accessibility of genomic sequences provides an inherent regulation mechanism for gene expression through variations in bending stiffness encoded by the nucleic acid sequence. Cyclization of dsDNA is the prevailing method for determining DNA bending stiffness. Recent cyclization data for short dsDNA raises several fundamental questions about the soundness of the cyclization method, particularly in cases where the probability of highly bent DNA conformations is low. We herein evaluate the role of T4 DNA ligase in the cyclization reaction by inserting an environmental sensitive base analogue, 2-amino purine, to the DNA molecule. By monitoring the 2-AP fluorescence under standard cyclization conditions, it is found that in addition to trapping highly-bent cyclic DNA conformations, T4 DNA ligase enhances the apparent base pair flip out rate, thus exaggerating the measured flexibility. This result is further confirmed using fluorescence anisotropy experiments. We show that fluorescence resonance energy transfer (FRET) measurements on suitably labeled dsDNA provides an alternative approach for quantifying the bending stiffness of short fragments. DNA bending stiffness results obtained using FRET are compared with literature values.
Measurement and Treatment of Passive Muscle Stiffness
Kirk, Henrik
This PhD thesis is based on research conducted at the University of Copenhagen and Helene Elsass Center from 2012 to 2015. Measurements and treatment of passive muscle stiffness in people with cerebral palsy (CP) comprise the focus of the thesis. The thesis summarizes the results from four studies...
Influence of footings stiffness on punching resistance
Ĺudovít Fillo
2016-03-01
Full Text Available The presented paper brings new aspects of punching resistance due to influence of footing stiffness and consequential ground stresses distribution. Diagrams of design load versus effective depth were created coming from new design criteria which depend on the maximum punching resistance defined from shear-bending failure and on the maximum punching resistance defined from crushing of concrete struts.
Improved Stiff ODE Solvers for Combustion CFD
Imren, A.; Haworth, D. C.
2016-11-01
Increasingly large chemical mechanisms are needed to predict autoignition, heat release and pollutant emissions in computational fluid dynamics (CFD) simulations of in-cylinder processes in compression-ignition engines and other applications. Calculation of chemical source terms usually dominates the computational effort, and several strategies have been proposed to reduce the high computational cost associated with realistic chemistry in CFD. Central to most strategies is a stiff ordinary differential equation (ODE) solver to compute the change in composition due to chemical reactions over a computational time step. Most work to date on stiff ODE solvers for computational combustion has focused on backward differential formula (BDF) methods, and has not explicitly considered the implications of how the stiff ODE solver couples with the CFD algorithm. In this work, a fresh look at stiff ODE solvers is taken that includes how the solver is integrated into a turbulent combustion CFD code, and the advantages of extrapolation-based solvers in this regard are demonstrated. Benefits in CPU time and accuracy are demonstrated for homogeneous systems and compression-ignition engines, for chemical mechanisms that range in size from fewer than 50 to more than 7,000 species.
Smith, Eric A.; Mehta, Amita V.
2008-01-01
The Mediterranean Sea is a noted 'concentration" basin in that it almost continuously exhibits positive evaporation minus precipitation (E - P ) properties -- throughout the four seasons and from one year to the next. Nonetheless, according to the ECMWF Era-40 48-year (1958-2005) climate reanalysis dataset, for various phases of the North Atlantic Oscillation (NAO) when the pressure gradient between Portugal and Iceland becomes either very relaxed (large negative NAO-Index) or in transition (small positive or negative NAO-Index), the atmospheric moisture source properties of the basin become weak, at times even reversed for several months (i.e., negative E - P). This behavior poses numerous questions concerning how and why these events occur. Moreover, it begs the question of what it would take for the basin to reach its tipping point in which P would exceed E throughout the rainy season (some six months) on an annually persistent basis -- and the sea would possibly transform to a recurring "dilution" basin. This talk investigates these questions by: (1) establishing over a period from 1979 to present, based on detailed analyses of satellite retrieval products from a combination of NASA-AQUA, NOAA-LEO, NASA/JAXA Scatterometer, and NASA-TRMM platforms, plus additional specialized satellite data products and ancillary meteorological datasets, the actual observation-based behavior of E - P, (2) diagnosing the salient physical and meteorological mechanisms that lead to the weaker E - P events during the analysis period, partly based on analyzing surface and upper air data at discrete stations in the western and eastern Mediterranean -- while at the same time evaluating the quality of the ERA-40 data over this same time period, (3) conducting GCM and high-resolution regional modeling experiments to determine if perturbed but realistic meteorological background conditions could maintain Mediterranean as a "dilution" basin through the October to March rainy season on
ON THE STIFFNESS OF DEMINERALIZED DENTIN MATRICES
Ryou, Heonjune; Turco, Gianluca; Breschi, Lorenzo; Tay, Franklin R.; Pashley, David H.; Arola, Dwayne
2015-01-01
Resin bonding to dentin requires the use of self-etching primers or acid etching to decalcify the surface and expose a layer of collagen fibrils of the dentin matrix. Acid-etching reduces the stiffness of demineralized dentin from approximately 19 GPa to 1 MPa, requiring that it floats in water to prevent it from collapsing during bonding procedures. Several publications show that crosslinking agents like gluteraladehyde, carbodiimide or grape seed extract can stiffen collagen and improve resin-dentin bond strength. Objective The objective was to assess a new approach for evaluating the changes in stiffness of decalcified dentin by polar solvents and a collagen cross-linker. Methods Fully demineralized dentin beams and sections of etched coronal dentin were subjected to indentation loading using a cylindrical flat indenter in water, and after treatment with ethanol or ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). The stiffness was measured as a function of strain and as a function of loading rate from 1 to 50 µm/sec. Results At a strain of 0.25% the elastic modulus of the fully demineralized dentin was approximately 0.20 MPa. It increased to over 0.90 MPa at strains of 1%. Exposure to ethanol caused an increase in elastic modulus of up to four times. Increasing the loading rate from 1 to 50 µm/sec caused an increase in the apparent modulus of up to three times in both water and ethanol. EDC treatment caused increases in the stiffness in fully demineralized samples and in acid-etched demineralized dentin surfaces in situ. Significance Changes in the mechanical behavior of demineralized collagen matrices can be measured effectively under hydration via indentation with cylindrical flat indenters. This approach can be used for quantifying the effects of bonding treatments on the properties of decalcified dentin after acid etching, as well as to follow the loss of stiffness over time due to enzymatic degradation. PMID:26747822
Evaluation of Compressive Strength and Stiffness of Grouted Soils by Using Elastic Waves
In-Mo Lee
2014-01-01
Full Text Available Cement grouted soils, which consist of particulate soil media and cementation agents, have been widely used for the improvement of the strength and stiffness of weak ground and for the prevention of the leakage of ground water. The strength, elastic modulus, and Poisson’s ratio of grouted soils have been determined by classical destructive methods. However, the performance of grouted soils depends on several parameters such as the distribution of particle size of the particulate soil media, grouting pressure, curing time, curing method, and ground water flow. In this study, elastic wave velocities are used to estimate the strength and elastic modulus, which are generally obtained by classical strength tests. Nondestructive tests by using elastic waves at small strain are conducted before and during classical strength tests at large strain. The test results are compared to identify correlations between the elastic wave velocity measured at small strain and strength and stiffness measured at large strain. The test results show that the strength and stiffness have exponential relationship with elastic wave velocities. This study demonstrates that nondestructive methods by using elastic waves may significantly improve the strength and stiffness evaluation processes of grouted soils.
Interactions between time-varying mesh stiffness and clearance non-linearities in a geared system
Kahraman, A.; Singh, R.
1991-04-01
Frequency response characteristics of a non-linear geared rotor-bearing system with time-varying mesh stiffness k h( overlinet) are examined in this paper. First, the single-degree-of-freedom spur gear pair model with backlash is extended to include sinusoidal or periodic mesh stiffness k h( overlinet) . Second, a three-degree-of-freedom model with k h( overlinet) and clearance non-lineariries associated with gear backlash and rolling element bearings, as excited by the static transmission error overlinee( overlinet) under a mean torque load, is developed. The governing equations are solved using digital simulation technique and only the primary resonances are studied. Resonances of the corresponding linear time-varying system associated with parametric and external excitations are identified using the method of multiple scales and digital simulation. Interactions between the mesh stiffness variation and clearance non-linearities have been investigated; a strong interaction between time-varying mesh stiffness k h( overlinet) and gear backlash is found, whereas the coupling between k h( overlinet) and bearing non-linearities is weak. Finally, our time-varying non-linear formulations yield reasonably good predictions when compared with the benchmark experimental results available in the literature.
A review on in situ stiffness adjustment methods in MEMS
de Laat, M. L. C.; Pérez Garza, H. H.; Herder, J. L.; Ghatkesar, M. K.
2016-06-01
In situ stiffness adjustment in microelectromechanical systems is used in a variety of applications such as radio-frequency mechanical filters, energy harvesters, atomic force microscopy, vibration detection sensors. In this review we provide designers with an overview of existing stiffness adjustment methods, their working principle, and possible adjustment range. The concepts are categorized according to their physical working principle. It is concluded that the electrostatic adjustment principle is the most applied method, and narrow to wide ranges in stiffness can be achieved. But in order to obtain a wide range in stiffness change, large, complex devices were designed. Mechanical stiffness adjustment is found to be a space-effective way of obtaining wide changes in stiffness, but these methods are often discrete and require large tuning voltages. Stiffness adjustment through stressing effects or change in Young’s modulus was used only for narrow ranges. The change in second moment of inertia was used for stiffness adjustment in the intermediate range.
Laterality and imbalance of muscle stiffness relate to personality.
Nakaya, Naoki; Kumano, Hiroaki; Minoda, Keiji; Kanazawa, Motoyori; Fukudo, Shin
2004-01-01
The authors' purpose in this study was to test the hypothesis that laterality and imbalance of muscle stiffness relate to personality. The authors selected 23 healthy volunteers and divided them into two groups based on the predominance of muscle stiffness on the left or right side. Imbalance of muscle stiffness was calculated as the absolute value of the difference of muscle stiffness between the right and left sides. The authors evaluated personality with the Japanese version of the Eysenck Personality Questionnaire. Subjects with left predominant muscle stiffness of the rectal abdominis had significantly higher neuroticism score than those with right predominant muscle stiffness. Subjects with more imbalance of muscle stiffness in the latissimus dorsi and in the trapezius had significantly higher neuroticism and psychoticism scores than those with less imbalance. The findings suggest that laterality and imbalance of muscle stiffness relate to personality.
Wykretowicz, Andrzej; Adamska, Karolina; Guzik, Przemyslaw; Krauze, Tomasz; Wysocki, Henryk
2007-10-01
1. Obesity appears to influence vascular stiffness, an important cardiovascular risk factor. An accurate picture of arterial stiffness may be obtained when a combination of various techniques is used. 2. The purpose of the present study was to assess whether the body mass index (BMI) and body fat content obtained by bioimpedance were of equal value in estimating the influence of body fatness on various indices of vascular stiffness and wave reflection. 3. A total of 175 healthy subjects was studied. Anthropometric measurements and total body bio-impedance analysis were performed to assess fat mass as a proportion of total body composition. Arterial stiffness and wave reflection were assessed using digital volume pulse analysis and tonometric measurement of the wave reflection indices and central haemodynamics. 4. Significant differences in the stiffness index (SI(DVP); P < 0.0001), peripheral augmentation index (pAI(x); P < 0.0001), central augmentation index (cAI(x); P < 0.0001), peripheral pulse pressure (pPP; P = 0.026) and central pulse pressure (cPP; P < 0.0001) were found when the population examined was divided accordingly to tertile of body fat content. However, subdividing various indices of arterial stiffness according to the tertile of BMI did not reveal any significant differences between groups, except for pPP and cPP. 5. Body fat content was significantly correlated with SI(DVP), pAI(x), cAI(x), pPP and cPP. The BMI correlated weakly with SI(DVP), pPP and cPP. 6. In conclusion, the BMI is not very useful in predicting changes in arterial stiffness and wave reflection due to obesity. However, stiffness and wave reflection indices derived from digital volume pulse analysis, the characteristics of radial and aortic pressure waveforms and peripheral and aortic pulse pressure are all related to body fat content, as estimated by bioimpedance.
Lamb Wave Stiffness Characterization of Composites Undergoing Thermal-Mechanical Aging
Seale, Michael D.; Madaras, Eric I.
2004-01-01
The introduction of new, advanced composite materials into aviation systems requires a thorough understanding of the long term effects of combined thermal and mechanical loading upon those materials. Analytical methods investigating the effects of intense thermal heating combined with mechanical loading have been investigated. The damage mechanisms and fatigue lives were dependent on test parameters as well as stress levels. Castelli, et al. identified matrix dominated failure modes for out-of-phase cycling and fiber dominated damage modes for in-phase cycling. In recent years, ultrasonic methods have been developed that can measure the mechanical stiffness of composites. To help evaluate the effect of aging, a suitably designed Lamb wave measurement system is being used to obtain bending and out-of-plane stiffness coefficients of composite laminates undergoing thermal-mechanical loading. The system works by exciting an antisymmetric Lamb wave and calculating the velocity at each frequency from the known transducer separation and the measured time-of-flight. The same peak in the waveforms received at various distances is used to measure the time difference between the signals. The velocity measurements are accurate and repeatable to within 1% resulting in reconstructed stiffness values repeatable to within 4%. Given the material density and plate thickness, the bending and out-of-plane shear stiffnesses are calculated from a reconstruction of the dispersion curve. A mechanical scanner is used to move the sensors over the surface to map the time-of-flight, velocity, or stiffnesses of the entire specimen. Access to only one side of the material is required and no immersion or couplants are required because the sensors are dry coupled to the surface of the plate. In this study, the elastic stiffnesses D(sub 11), D(sub 22), A(sub 44), and A(sub 55) as well as time-of-flight measurements for composite samples that have undergone combined thermal and mechanical aging for
Analysis of phase-locked loop influence on the stability of single-phase grid-connected inverter
Zhang, Chong; Wang, Xiongfei; Blaabjerg, Frede
2015-01-01
A controlled power inverter can cause instability at the point of common coupling (PCC) with its output filter and the grid. This paper analyzes the influence of the Phase-Locked Loop (PLL) on the output admittance of single-phase current-controlled inverters with different grid stiffness. It shows...... that the PLL introduces a paralleled admittance into the output admittance of the inverter, which may lead to unintentional low-order harmonic oscillation in a weak grid. Moreover, the Second Order Generalized Integrator PLL (SOGI-PLL) is also modeled. It is found that the quadrature signal generator of SOGI...... plays a stabilizing role in grid-inverter interactions, which thus provides a promising candidate for avoiding the PLL-induced instability in single-phase inverters. Simulation results are presented for verifying the theoretical analysis. The possible instability due to different PLL bandwidth is also...
How Crouch Gait Can Dynamically Induce Stiff-Knee Gait
Van der Krogt, M.M.; Bregman, D.J.J.; Wisse, M.; Doorenbosch, C.A.M.; Harlaar, J.; Collins, S.H.
Children with cerebral palsy frequently experience foot dragging and tripping during walking due to a lack of adequate knee flexion in swing (stiff-knee gait). Stiff-knee gait is often accompanied by an overly flexed knee during stance (crouch gait). Studies on stiff-knee gait have mostly focused on
How Crouch Gait Can Dynamically Induce Stiff-Knee Gait
Van der Krogt, M.M.; Bregman, D.J.J.; Wisse, M.; Doorenbosch, C.A.M.; Harlaar, J.; Collins, S.H.
Children with cerebral palsy frequently experience foot dragging and tripping during walking due to a lack of adequate knee flexion in swing (stiff-knee gait). Stiff-knee gait is often accompanied by an overly flexed knee during stance (crouch gait). Studies on stiff-knee gait have mostly focused on
A novel energy-efficient rotational variable stiffness actuator
Rao, Shodhan; Carloni, Raffaella; Stramigioli, Stefano
2011-01-01
This paper presents the working principle, the design and realization of a novel rotational variable stiffness actuator, whose stiffness can be varied independently of its output angular position. This actuator is energy-efficient, meaning that the stiffness of the actuator can be varied by keeping
A novel energy-efficient rotational variable stiffness actuator
Rao, S.; Carloni, Raffaella; Stramigioli, Stefano
This paper presents the working principle, the design and realization of a novel rotational variable stiffness actuator, whose stiffness can be varied independently of its output angular position. This actuator is energy-efficient, meaning that the stiffness of the actuator can be varied by keeping
Dosen, K
2010-01-01
An operad (this paper deals with non-symmetric operads) may be conceived as a partial algebra with a family of insertion operations, Gerstenhaber's circle-i products, which satisfy two kinds of associativity, one of them involving commutativity. A Cat-operad is an operad enriched over the category Cat of small categories, as a 2-category with small hom-categories is a category enriched over Cat. The notion of weak Cat-operad is to the notion of Cat-operad what the notion of bicategory is to the notion of 2-category. The equations of operads like associativity of insertions are replaced by isomorphisms in a category. The goal of this paper is to formulate conditions concerning these isomorphisms that ensure coherence, in the sense that all diagrams of canonical arrows commute. This is the sense in which the notions of monoidal category and bicategory are coherent. The coherence proof in the paper is much simplified by indexing the insertion operations in a context-independent way, and not in the usual manner. ...
[Stiff person syndrome--case report].
Tomczykiewicz, Kazimierz; Pastuszak, Zanna; Staszewski, Jacek; Stepień, Adam
2014-01-01
Stiff person syndrome (SPS) is the rare disease and cause great inefficient. It is characterized by progressive stiffness muscles of trunk and the limbs on which the cramps of muscles overlap. In the electrophysiological investigation of the patients the involuntary discharge of motor unit potentials find and also simultaneous contraction agonistic and antagonistic muscles. SPS is presented with insulin-dependent diabetes mellitus often or is the symptom of the paraneoplastic syndrome. It is commonly associated with high anti-glutamic acid decarboxylaze (GAD) antibody titters in the serum of the blood of patients. Establishing the diagnosis can cause difficulties. We observed the patient in the last period about the atypical course the disease. The diagnosis was confirmed occurrences of the high titters of antibodies anti-GAD, the discharge of motor unit potential in paraspinal muscles in the rest and good response the treatment with diazepamem.
The Stress and Stiffness Analysis of Diaphragm
Qu Dongyue
2017-01-01
Full Text Available Diaphragm coupling with its simple structure, small size, high reliability, which can compensate for its input and output displacement deviation by its elastic deformation, is widely used in aerospace, marine, and chemical etc. This paper uses the ANSYS software and its APDL language to analysis the stress distribution when the diaphragm under the load of torque, axial deviation, centrifugal force, angular deviation and multiple loads. We find that the value of maximum stress usually appears in the outer or inner transition region and the axial deviation has a greater influence to the distribution of the stress. Based on above, we got three kinds of stiffness for axial, angular and torque, which the stiffness of diaphragm is nearly invariable. The results can be regard as an important reference for design and optimization of diaphragm coupling.
Electron profile stiffness and critical gradient studies
DeBoo, J. C.; Petty, C. C.; White, A. E.; Burrell, K. H.; Doyle, E. J.; Hillesheim, J. C.; Holland, C.; McKee, G. R.; Rhodes, T. L.; Schmitz, L.; Smith, S. P.; Wang, G.; Zeng, L.
2012-08-01
Electron profile stiffness was studied in DIII-D L-mode discharges by systematically varying the heat flux in a narrow region with electron cyclotron heating and measuring the local change produced in ∇Te. Electron stiffness was found to slowly increase with toroidal rotation velocity. A critical inverse temperature gradient scale length 1/LC ˜ 3 m-1 was identified at ρ =0.6 and found to be independent of rotation. Both the heat pulse diffusivity and the power balance diffusivity, the latter determined by integrating the measured dependence of the heat pulse diffusivity on -∇Te, were fit reasonably well by a model containing a critical inverse temperature gradient scale length and varying linearly with 1/LT above the threshold.
Lada, Aleksandra; Ibsen, Lars Bo; Nicolai, Giulio
In the paper the experimental results of small-scale tests on a stiff monopile are presented to outline the change in stiffness during the cyclic loading and the change in the ultimate pile capacity. The results confirm the increase of stiffness and the increase in bearing capacity resulting from...... cyclic loading. Performed analysis provides a better understanding of the problem and reveals some correlations that can be useful in the future design of stiff monopiles....
Wen-ku Shi; Cheng Liu; Zhi-yong Chen; Wei He; Qing-hua Zu
2016-01-01
The composite stiffness of parabolic leaf springs with variable stiffness is difficult to calculate using traditional integral equations. Numerical integration or FEA may be used but will require computer-aided software and long calculation times. An efficient method for calculating the composite stiffness of parabolic leaf springs with variable stiffness is developed and evaluated to reduce the complexity of calculation and shorten the calculation time. A simplified model for double-leaf spr...
Weak localization in few-layer black phosphorus
Du, Yuchen; Neal, Adam T.; Zhou, Hong; Ye, Peide D.
2016-06-01
We have conducted a comprehensive investigation into the magneto-transport properties of few-layer black phosphorus in terms of phase coherence length, phase coherence time, and mobility via weak localization measurement and Hall-effect measurement. We present magnetoresistance data showing the weak localization effect in bare p-type few-layer black phosphorus and reveal its strong dependence on temperature and carrier concentration. The measured weak localization agrees well with the Hikami-Larkin-Nagaoka model and the extracted phase coherence length of 104 nm at 350 mK, decreasing as ˜T-0.513+-0.053 with increased temperature. Weak localization measurement allows us to qualitatively probe the temperature-dependent phase coherence time τ ϕ , which is in agreement with the theory of carrier interaction in the diffusive regime. We also observe the universal conductance fluctuation phenomenon in few-layer black phosphorus within moderate magnetic field and low temperature regime.
Stiff modes in spinvalve simulations with OOMMF
Mitropoulos, Spyridon [Department of Computer and Informatics Engineering, TEI of Eastern Macedonia and Thrace, Kavala (Greece); Tsiantos, Vassilis, E-mail: tsianto@teikav.edu.gr [Department of Electrical Engineering, TEI of Eastern Macedonia and Thrace, Kavala, 65404 Greece (Greece); Ovaliadis, Kyriakos [Department of Electrical Engineering, TEI of Eastern Macedonia and Thrace, Kavala, 65404 Greece (Greece); Kechrakos, Dimitris [Department of Education, ASPETE, Heraklion, Athens (Greece); Donahue, Michael [Applied and Computational Mathematics Division, NIST, Gaithersburg, MD (United States)
2016-04-01
Micromagnetic simulations are an important tool for the investigation of magnetic materials. Micromagnetic software uses various techniques to solve differential equations, partial or ordinary, involved in the dynamic simulations. Euler, Runge-Kutta, Adams, and BDF (Backward Differentiation Formulae) are some of the methods used for this purpose. In this paper, spinvalve simulations are investigated. Evidence is presented showing that these systems have stiff modes, and that implicit methods such as BDF are more effective than explicit methods in such cases.
MIGRAINE, CAROTID STIFFNESS AND GENETIC POLYMORPHISM.
Kes, Vanja Basić; Jurasić, Miljenka-Jelena; Zavoreo, Iris; Corić, Lejla; Rotim, Kresimir
2015-12-01
Recently migraine has been associated with increased arterial stiffness, procoagulant state, increased incidence of cerebral white matter lesions (WML) and stroke. Our aim was to compare the characteristics of migraineurs to headache free controls regarding their functional carotid ultrasound parameters. Sixty patients (45 women) with migraine (mean age 40.42 ± 10.61 years) were compared with 45 controls (30 women) with no prior history of repeating headache (mean age 38.94 ± 5.46 years) using E-tracking software on Alpha 10 ultrasound platform. Student's t-test was used on statistical analysis with alpha < 0.05. All tested carotid vascular parameters were worse in patients with migraine including increased intima-media thickness, greater carotid diameter and carotid diameter change, as well as several arterial stiffness indices. Additionally, patients with migraine had greater incidence of homozygous mutations for procoagulant genes (MTHFR (C677T), PAI-1 and ACE I/D) than expected. Computed tomography and magnetic resonance imaging of the brain showed WML in 11 patients, four of them migraine with aura patients. Since we established increased carotid stiffness and higher frequency of procoagulant gene mutations in migraineurs, we propose prospective ultrasound monitoring in such patients, especially those with detected WML, in order to timely commence more active and specific preventive stroke management strategies.
Bending stiffness and interlayer shear modulus of few-layer graphene
Chen, Xiaoming; Yi, Chenglin; Ke, Changhong, E-mail: cke@binghamton.edu [Department of Mechanical Engineering, State University of New York at Binghamton, Binghamton, New York 13902 (United States)
2015-03-09
Interlayer shear deformation occurs in the bending of multilayer graphene with unconstrained ends, thus influencing its bending rigidity. Here, we investigate the bending stiffness and interlayer shear modulus of few-layer graphene through examining its self-folding conformation on a flat substrate using atomic force microscopy in conjunction with nonlinear mechanics modeling. The results reveal that the bending stiffness of 2–6 layers graphene follows a square-power relationship with its thickness. The interlayer shear modulus is found to be in the range of 0.36–0.49 GPa. The research findings show that the weak interlayer shear interaction has a substantial stiffening effect for multilayer graphene.
Synchronization of cardiorhythm by weak external forcing
V. S. Anishchenko
2000-01-01
Full Text Available We study the possibility to synchronize cardiorhythm of a human by periodic and aperiodic sequences of light and sound pulses. Aperiodic forcing is defined by variation of RR intervals of another subject. Phase locking between cardiorhythm and weak external forcing is detected on finite time intervals. We observe the 1:1 synchronization for periodic forcing and n:m synchronization for aperiodic one.
Weak Total Resolvability In Graphs
Casel Katrin
2016-02-01
Full Text Available A vertex v ∈ V (G is said to distinguish two vertices x, y ∈ V (G of a graph G if the distance from v to x is di erent from the distance from v to y. A set W ⊆ V (G is a total resolving set for a graph G if for every pair of vertices x, y ∈ V (G, there exists some vertex w ∈ W − {x, y} which distinguishes x and y, while W is a weak total resolving set if for every x ∈ V (G−W and y ∈ W, there exists some w ∈ W −{y} which distinguishes x and y. A weak total resolving set of minimum cardinality is called a weak total metric basis of G and its cardinality the weak total metric dimension of G. Our main contributions are the following ones: (a Graphs with small and large weak total metric bases are characterised. (b We explore the (tight relation to independent 2-domination. (c We introduce a new graph parameter, called weak total adjacency dimension and present results that are analogous to those presented for weak total dimension. (d For trees, we derive a characterisation of the weak total (adjacency metric dimension. Also, exact figures for our parameters are presented for (generalised fans and wheels. (e We show that for Cartesian product graphs, the weak total (adjacency metric dimension is usually pretty small. (f The weak total (adjacency dimension is studied for lexicographic products of graphs.
A General Formulation for the Stiffness Matrix of Parallel Mechanisms
Quennouelle, Cyril
2012-01-01
Starting from the definition of a stiffness matrix, the authors present a new formulation of the Cartesian stiffness matrix of parallel mechanisms. The proposed formulation is more general than any other stiffness matrix found in the literature since it can take into account the stiffness of the passive joints, it can consider additional compliances in the joints or in the links and it remains valid for large displacements. Then, the validity, the conservative property, the positive definiteness and the relation with other formulations of stiffness matrices are discussed theoretically. Finally, a numerical example is given in order to illustrate the correctness of this matrix.
Ratnasamy Muniandy
2006-01-01
Full Text Available Stone Matrix Asphalt (SMA is a gap-graded mix that is gaining popularity worldwide. Generally, gap graded mixes are thought to be weak in fatigue resistance. In this study, cellulose fibers were pre-blended in PG64-22 binder with fiber proportions of 0.2%, 0.4%, 0.6%, 0.8% and 1.0% by weight of aggregates. The fiber-modified binder showed improved rheological properties and showed that the PG64-22 binder can be modified and raised to PG70-22 grade. The cellulose oil palm fiber (COPF was found to improve the diameteral fatigue performance of SMA design mix. The fatigue life increased to a maximum at a fiber content of about 0.6%, whilst the tensile stress and stiffness also showed a similar trend in performance. The initial strains of the mix were lowest at a fiber content of 0.6%.
Regional brain stiffness changes across the Alzheimer's disease spectrum.
Murphy, Matthew C; Jones, David T; Jack, Clifford R; Glaser, Kevin J; Senjem, Matthew L; Manduca, Armando; Felmlee, Joel P; Carter, Rickey E; Ehman, Richard L; Huston, John
2016-01-01
Magnetic resonance elastography (MRE) is an MRI-based technique to noninvasively measure tissue stiffness. Currently well established for clinical use in the liver, MRE is increasingly being investigated to measure brain stiffness as a novel biomarker of a variety of neurological diseases. The purpose of this work was to apply a recently developed MRE pipeline to measure regional brain stiffness changes in human subjects across the Alzheimer's disease (AD) spectrum, and to gain insights into the biological processes underlying those stiffness changes by correlating stiffness with existing biomarkers of AD. The results indicate that stiffness changes occur mostly in the frontal, parietal and temporal lobes, in accordance with the known topography of AD pathology. Furthermore, stiffness in those areas correlates with existing imaging biomarkers of AD including hippocampal volumes and amyloid PET. Additional analysis revealed preliminary but significant evidence that the relationship between brain stiffness and AD severity is nonlinear and non-monotonic. Given that similar relationships have been observed in functional MRI experiments, we used task-free fMRI data to test the hypothesis that brain stiffness was sensitive to structural changes associated with altered functional connectivity. The analysis revealed that brain stiffness is significantly and positively correlated with default mode network connectivity. Therefore, brain stiffness as measured by MRE has potential to provide new and essential insights into the temporal dynamics of AD, as well as the relationship between functional and structural plasticity as it relates to AD pathophysiology.
Cosmology with a stiff matter era
Chavanis, Pierre-Henri
2015-11-01
We consider the possibility that the Universe is made of a dark fluid described by a quadratic equation of state P =K ρ2 , where ρ is the rest-mass density and K is a constant. The energy density ɛ =ρ c2+K ρ2 is the sum of two terms: a rest-mass term ρ c2 that mimics "dark matter" (P =0 ) and an internal energy term u =K ρ2=P that mimics a "stiff fluid" (P =ɛ ) in which the speed of sound is equal to the speed of light. In the early universe, the internal energy dominates and the dark fluid behaves as a stiff fluid (P ˜ɛ , ɛ ∝a-6). In the late universe, the rest-mass energy dominates and the dark fluid behaves as pressureless dark matter (P ≃0 , ɛ ∝a-3). We provide a simple analytical solution of the Friedmann equations for a universe undergoing a stiff matter era, a dark matter era, and a dark energy era due to the cosmological constant. This analytical solution generalizes the Einstein-de Sitter solution describing the dark matter era, and the Λ CDM model describing the dark matter era and the dark energy era. Historically, the possibility of a primordial stiff matter era first appeared in the cosmological model of Zel'dovich where the primordial universe is assumed to be made of a cold gas of baryons. A primordial stiff matter era also occurs in recent cosmological models where dark matter is made of relativistic self-gravitating Bose-Einstein condensates (BECs). When the internal energy of the dark fluid mimicking stiff matter is positive, the primordial universe is singular like in the standard big bang theory. It expands from an initial state with a vanishing scale factor and an infinite density. We consider the possibility that the internal energy of the dark fluid is negative (while, of course, its total energy density is positive), so that it mimics anti-stiff matter. This happens, for example, when the BECs have an attractive self-interaction with a negative scattering length. In that case, the primordial universe is nonsingular and
On prestress stiffness analysis of bolt-plate contact assemblies
Pedersen, Niels Leergaard; Pedersen, Pauli
2008-01-01
Bolt connections are among the most important connections used in structures. The stiffnesses of the bolt and of the connected members are the primary qualities that control the lifetime of the connection. The stiffness of the bolt can be estimated rather easily, in contrast to the member stiffness......, but with finite element (FE) and contact analysis, it is possible to find the stiffness of the member. In the case of many connections and for practical applications, it is not suitable to make a full FE analysis. The purpose of the present paper is to find simplified expressions for the stiffness of the member......, including the case when the width of the member is limited. The calculation of the stiffness is based on the FE, including the solution to the contact problem, and we express the stiffness as a function of the elastic energy in the structure, whereby the definition of the displacements related...
Weak compactness of biharmonic maps
Shenzhou Zheng
2012-10-01
Full Text Available This article shows that if a sequence of weak solutions of a perturbed biharmonic map satisfies $Phi_ko 0$ in $(W^{2,2}^*$ and $u_kightharpoonup u$ weakly in $W^{2,2}$, then $u$ is a biharmonic map. In particular, we show that the space of biharmonic maps is sequentially compact under the weak-$W^{2,2}$ topology.
Elastic stiffness and damping measurements in titanium alloys using atomic force acoustic microscopy
Kalyan Phani, M. [Metallurgy and Materials Group, Indira Gandhi Centre for Atomic Research, Kalpakkam, 603102 Tamil Nadu (India); Kumar, Anish, E-mail: anish@igcar.gov.in [Metallurgy and Materials Group, Indira Gandhi Centre for Atomic Research, Kalpakkam, 603102 Tamil Nadu (India); Arnold, W. [Department of Materials and Materials Technology, Saarland University, Campus D 2.2, D-66123 Saarbrücken (Germany); 1. Physikalisches Institut, Georg-August-Universität, Friedrich Hund Platz 1, D-37077 Göttingen (Germany); Samwer, K. [1. Physikalisches Institut, Georg-August-Universität, Friedrich Hund Platz 1, D-37077 Göttingen (Germany)
2016-08-15
Atomic force acoustic microscopy (AFAM) has been used to study the distribution of elastic stiffness and damping properties across different phases, such as α &β phases in a β titanium alloy (Ti−10V−4.5Fe−1.5Al) and α, β and α′ phases in an α + β alloy (Ti−6Al−4V). Contact-resonance spectra were obtained with a 100 nm spatial resolution in various specimens of the two titanium alloys heat-treated at different temperatures. The study indicates that the metastable β phase has the minimum modulus and maximum damping followed by α′ and α-phases. Employing the rule of mixtures, the average modulus measured by AFAM was then compared with the modulus obtained by ultrasonic velocity measurements. The error in the average modulus values obtained by both techniques is discussed. - Highlights: • Mapping of elastic stiffness and damping across various phases in titanium alloys. • Influence of alloy chemistry and crystal orientation on the results are discussed. • β phase has the minimum modulus and maximum damping followed by α′ and α-phases. • Average modulus of sample calculated from AFAM measurements on individual phases.
Thompson′s quadricepsplasty for stiff knee
Kundu Z
2007-01-01
Full Text Available Background : Stiffness of the knee after trauma and/or surgery for femoral fractures is one of the most common complications and is difficult to treat. Stiffness in extension is more common and can be reduced by vigorous physiotherapy. If it does not improve then quadricepsplasty is indicated. The present study was undertaken to evaluate the results of Thompsons quadricepsplasty. Materials and Methods : 22 male patients (age range 20-45 years with posttraumatic knee stiffness following distal femoral fractures underwent Thompson′s quadricepsplasty where knee flexion range was less than 45°. The index injury in these patients was treated with plaster cast (n=5, plates (n=3, intramedullary nailing (n=3 and external fixator for open fractures (n=9. Thompson′s quadricepsplasty was performed in all the patients using anterior approach, with incision extending from upper thigh to tibial tubercle. Release of rectus femoris from underlying vastus intermedius and release of intraarticular adhesions were performed. After surgery the patients needed parentral analgesia for three days and then oral analgesics for three weeks. Active assisted knee mobilization exercises were started on the first post-operative day. Continous passive motion machine was used from the same day. Supervised physiotherapy was continued in hospital for six weeks followed by intensive knee flexion and extension exercise including cycling at home for atleast another six months. Results : Out of 22 patients, 20 had excellent to good results and two patients had poor results using criteria devised by Judet. One poor result was due to peroperative fracture of patella which was then internally fixed and hence the flexion of knee could not be started immediately. There was peroperative avulsion of tibial tuberosity in another patient who finally gained less than 50° knee flexion and hence a poor result. Conclusion : Thompsons quadricepsplasty followed by a strict and rigourous
Cryotherapy induces an increase in muscle stiffness.
Point, Maxime; Guilhem, Gaël; Hug, François; Nordez, Antoine; Frey, Alain; Lacourpaille, Lilian
2017-03-06
Although cold application (i.e., cryotherapy) may be useful to treat sports injuries and to prevent muscle damage, it is unclear whether it has adverse effects on muscle mechanical properties. This study aimed to determine the effect of air-pulsed cryotherapy on muscle stiffness estimated using ultrasound shear wave elastography. Myoelectrical activity, ankle passive torque, shear modulus (an index of stiffness) and muscle temperature of the gastrocnemius medialis were measured before, during an air-pulsed cryotherapy (-30°) treatment of 4 sets of 4 minutes with 1 min recovery in between, and during a 40-min post-cryotherapy period. Muscle temperature significantly decreased after the second set of treatment (10 min: 32.3 ± 2.5°C; P < 0.001), peaked at 29 min (27.9 ± 2.2°C; P < 0.001) and remained below baseline values at 60 minutes (29.5 ± 2.0°C; P < 0.001). Shear modulus increased by +11.5 ± 11.8% after the second set (10 min; P = 0.011), peaked at 30 min (+34.7 ± 42.6%; P < 0.001) and remained elevated until the end of the post-treatment period (+25.4 ± 17.1%; P < 0.001). These findings provide evidence that cryotherapy induces an increase in muscle stiffness. This acute change in muscle mechanical properties may lower the amount of stretch that the muscle tissue is able to sustain without subsequent injury. This should be considered when using cryotherapy in athletic practice. This article is protected by copyright. All rights reserved.
Laser application on haptics: Tactile stiffness measurement
Scalise, L.; Memeo, M.; Cannella, F.; Valente, M.; Caldwell, D. G.; Tomasini, E. P.
2012-06-01
There is a great interest in exploring the proprieties of the sense of the touch, its detailed knowledge in fact is a key issue in the area of robotics, haptics and human-machine interaction. In this paper, the authors focus their attention on a novel measurement method for the assessment of the tactile stiffness based on a original test rig; tactile stiffness is defined as the ratio between force, exerted by the finger, and the displacement of the finger tip operated during the test. To reach this scope, the paper describes a specific experimental test-rig used for the evaluation of subject tactile sensitivity, where finger force applied during tests as well as displacement and velocity of displacement, operated by the subject under investigation, are measured. Results show that tactile stiffness is linear respect to stimuli spatial difference (which is proportional to the difficulty to detect the variation of them). In particular, it has been possible to relate the force and displacement measured during the tests. The relationship between the response of the subject to the grating, velocity and force is determined. These results permit to carry out the further experimental tests on the same subject avoiding the use of a load cell and therefore simplifying the measurement test rig and data post-processing. Indeed, the first aspect (use of a load cell) can be relevant, because the grating positions are different, requiring a specific re-calibration and setting before each trial; while the second aspect allows simplify the test rig complexity and the processing algorithm.
[Systemic lupus erythematosus and weakness].
Vinagre, Filipe; Santos, Maria José; da Silva, José Canas
2006-01-01
We report a case of a 13-year old young girl, with Juvenile Systemic Lupus Erythematosus and recent onset of muscle weakness. Investigations lead to the diagnosis of Myasthenia Gravis. The most important causes of muscle weakness in lupus patients are discussed.
Three-dimensional stiffness of the carpal arch.
Gabra, Joseph N; Li, Zong-Ming
2016-01-01
The carpal arch of the wrist is formed by irregularly shaped carpal bones interconnected by numerous ligaments, resulting in complex structural mechanics. The purpose of this study was to determine the three-dimensional stiffness characteristics of the carpal arch using displacement perturbations. It was hypothesized that the carpal arch would exhibit an anisotropic stiffness behavior with principal directions that are oblique to the conventional anatomical axes. Eight (n=8) cadavers were used in this study. For each specimen, the hamate was fixed to a custom stationary apparatus. An instrumented robot arm applied three-dimensional displacement perturbations to the ridge of trapezium and corresponding reaction forces were collected. The displacement-force data were used to determine a three-dimensional stiffness matrix using least squares fitting. Eigendecomposition of the stiffness matrix was used to identify the magnitudes and directions of the principal stiffness components. The carpal arch structure exhibited anisotropic stiffness behaviors with a maximum principal stiffness of 16.4±4.6N/mm that was significantly larger than the other principal components of 3.1±0.9 and 2.6±0.5N/mm (pcarpal tunnel which is accounted for by the stiff transverse ligaments that tightly bind distal carpal arch. The minimal principal stiffness is attributed to the less constraining articulation between the trapezium and scaphoid. This study provides advanced characterization of the wrist׳s three-dimensional structural stiffness for improved insight into wrist biomechanics, stability, and function.
Effective stiffness and formation of secondary structures in a protein-like model
Škrbić, Tatjana; Hoang, Trinh X.; Giacometti, Achille
2016-08-01
We use Wang-Landau and replica exchange techniques to study the effect of an increasing stiffness on the formation of secondary structures in protein-like systems. Two possible models are considered. In both models, a polymer chain is formed by tethered beads where non-consecutive backbone beads attract each other via a square-well potential representing the tendency of the chain to fold. In addition, smaller hard spheres are attached to each non-terminal backbone bead along the direction normal to the chain to mimic the steric hindrance of side chains in real proteins. The two models, however, differ in the way bending rigidity is enforced. In the first model, partial overlap between consecutive beads is allowed. This reduces the possible bending angle between consecutive bonds thus producing an effective entropic stiffness that competes with a short-range attraction, and leads to the formation of secondary structures characteristic of proteins. We discuss the low-temperature phase diagram as a function of increasing interpenetration and find a transition from a planar, beta-like structure, to helical shape. In the second model, an energetic stiffness is explicitly introduced by imposing an infinitely large energy penalty for bending above a critical angle between consecutive bonds, and no penalty below it. The low-temperature phase of this model does not show any sign of protein-like secondary structures. At intermediate temperatures, however, where the chain is still in the coil conformation but stiffness is significant, we find the two models to predict a quite similar dependence of the persistence length as a function of the stiffness. This behaviour is rationalized in terms of a simple geometrical mapping between the two models. Finally, we discuss the effect of shrinking side chains to zero and find the above mapping to still hold true.
Síndrome stiff skin: relato de caso Stiff skin syndrome: case report
Adriana Gutstein da Fonseca Amorim
2011-08-01
Full Text Available Síndrome stiff skin é doença rara, esclerodermiforme, de etiologia desconhecida, caracterizada por endurecimento pétreo da pele, hipertricose leve e limitação da mobilidade articular. Não há tratamento efetivo até o momento. Exercícios e reabilitação são importantes para manter a qualidade de vida do paciente. Os autores apresentam caso de um menino de dois anos de idade com endurecimento cutâneo progressivo desde os oito meses de idade e restrição secundária da mobilidade articular, diagnosticado como Síndrome stiff skinStiff skin syndrome is a rare scleroderma-like disorder of unknown etiology characterized by stone-hard indurations of skin, mild hypertrichosis and limited joint mobility. No effective treatment has yet been found. Exercises and rehabilitative therapy are important in maintaining the patient's quality of life. The authors present a case of a two-year-old boy with progressive skin hardening since he was eightmonth old and secondary restricted joint mobility, diagnosed as Stiff skin syndrome
The flexural stiffness and tension state of basalt filter
Khalmuradovich, Sattarov Laziz; Ahmedovich, Kurbanov Abdirahim
2017-03-01
In recent years, there is a growing demand in Uzbekistan for new, cheap and competitive products from local raw materials, the demand being directly connected with the expansion and development opportunities of the mining, metallurgical and processing industries. In such conditions, the need for providing a solution of the problems faced by these industries is a very urgent one and requires further comprehensive studies. One of these tasks includes assessment of the force parameters and bending stiffness of basalt fibre filters, aimed at further improving the efficiency of local basalt raw materials and aiding in the manufacture of new, long-lasting, reliable and high-quality products. In this case, we studied the interaction of basalt fibre filter with a gas or liquid medium, the deformed state of the fibres under the action force of the gas or liquid, and the filter recovery process after removal of the load, all of which occur during mechanical filtration. These tasks are of interest because during the mechanical filtration of a gas or liquid (hereinafter, mechanical filtration) from solids, all attention is paid to the quality of the filtering process. The filtering quality, as known, is determined by the degree of contamination in the liquid undergoing treatment, duration of separation of the pulp into solid and liquid phases during the decantation process of the mixture and the amount of gas/ liquid released into the atmosphere along with carbon monoxide and toxic impurities. At the same time, the state and behaviour of the filtering material remain as minor factors, the consideration of which can play a decisive role in the establishment of filter life and work capacity. Solutions to these problems are very urgent and allow one to create new technologies for the production of basalt filters based on force parameters and bending stiffness, wherein the purification occurs without the intervention of chemicals.
Multifunctional Stiff Carbon Foam Derived from Bread.
Yuan, Ye; Ding, Yujie; Wang, Chunhui; Xu, Fan; Lin, Zaishan; Qin, Yuyang; Li, Ying; Yang, Minglong; He, Xiaodong; Peng, Qingyu; Li, Yibin
2016-07-06
The creation of stiff yet multifunctional three-dimensional porous carbon architecture at very low cost is still challenging. In this work, lightweight and stiff carbon foam (CF) with adjustable pore structure was prepared by using flour as the basic element via a simple fermentation and carbonization process. The compressive strength of CF exhibits a high value of 3.6 MPa whereas its density is 0.29 g/cm(3) (compressive modulus can be 121 MPa). The electromagnetic interference (EMI) shielding effectiveness measurements (specific EMI shielding effectiveness can be 78.18 dB·cm(3)·g(-1)) indicate that CF can be used as lightweight, effective shielding material. Unlike ordinary foam structure materials, the low thermal conductivity (lowest is 0.06 W/m·K) with high resistance to fire makes CF a good candidate for commercial thermal insulation material. These results demonstrate a promising method to fabricate an economical, robust carbon material for applications in industry as well as topics regarding environmental protection and improvement of energy efficiency.
Elastic metamaterial beam with remotely tunable stiffness
Qian, Wei [University of Michigan–Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University, Shanghai 200240 (China); Yu, Zhengyue [School of Naval Architecture, Ocean & Civil Engineering, Shanghai Jiao Tong University, Shanghai 200240 (China); Wang, Xiaole [School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240 (China); Lai, Yun [College of Physics, Optoelectronics and Energy & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215006 (China); Yellen, Benjamin B., E-mail: yellen@duke.edu [University of Michigan–Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University, Shanghai 200240 (China); Department of Mechanical Engineering and Materials Science, Duke University, P.O. Box 90300, Hudson Hall, Durham, North Carolina 27708 (United States)
2016-02-07
We demonstrate a dynamically tunable elastic metamaterial, which employs remote magnetic force to adjust its vibration absorption properties. The 1D metamaterial is constructed from a flat aluminum beam milled with a linear array of cylindrical holes. The beam is backed by a thin elastic membrane, on which thin disk-shaped permanent magnets are mounted. When excited by a shaker, the beam motion is tracked by a Laser Doppler Vibrometer, which conducts point by point scanning of the vibrating element. Elastic waves are unable to propagate through the beam when the driving frequency excites the first elastic bending mode in the unit cell. At these frequencies, the effective mass density of the unit cell becomes negative, which induces an exponentially decaying evanescent wave. Due to the non-linear elastic properties of the membrane, the effective stiffness of the unit cell can be tuned with an external magnetic force from nearby solenoids. Measurements of the linear and cubic static stiffness terms of the membrane are in excellent agreement with experimental measurements of the bandgap shift as a function of the applied force. In this implementation, bandgap shifts by as much as 40% can be achieved with ∼30 mN of applied magnetic force. This structure has potential for extension in 2D and 3D, providing a general approach for building dynamically tunable elastic metamaterials for applications in lensing and guiding elastic waves.
Elastic metamaterial beam with remotely tunable stiffness
Qian, Wei; Yu, Zhengyue; Wang, Xiaole; Lai, Yun; Yellen, Benjamin B.
2016-02-01
We demonstrate a dynamically tunable elastic metamaterial, which employs remote magnetic force to adjust its vibration absorption properties. The 1D metamaterial is constructed from a flat aluminum beam milled with a linear array of cylindrical holes. The beam is backed by a thin elastic membrane, on which thin disk-shaped permanent magnets are mounted. When excited by a shaker, the beam motion is tracked by a Laser Doppler Vibrometer, which conducts point by point scanning of the vibrating element. Elastic waves are unable to propagate through the beam when the driving frequency excites the first elastic bending mode in the unit cell. At these frequencies, the effective mass density of the unit cell becomes negative, which induces an exponentially decaying evanescent wave. Due to the non-linear elastic properties of the membrane, the effective stiffness of the unit cell can be tuned with an external magnetic force from nearby solenoids. Measurements of the linear and cubic static stiffness terms of the membrane are in excellent agreement with experimental measurements of the bandgap shift as a function of the applied force. In this implementation, bandgap shifts by as much as 40% can be achieved with ˜30 mN of applied magnetic force. This structure has potential for extension in 2D and 3D, providing a general approach for building dynamically tunable elastic metamaterials for applications in lensing and guiding elastic waves.
Performance of Variable Negative Stiffness MRE Vibration Isolation System
Run-pu Li
2015-01-01
Full Text Available Magnetorheological elastomer (MRE vibration isolation devices can improve a system’s vibration response via adjustable stiffness and damping under different magnetic fields. Combined with negative stiffness design, these MRE devices can reduce a system’s stiffness and improve the vibration control effect significantly. This paper develops a variable negative stiffness MRE isolation device by combining an improved separable iron core with laminated MREs. The relationship between the negative stiffness and the performance of the device is obtained by mathematical transformation. Its vibration response under simple harmonic excitation at small amplitude and the impact of the volume fraction of soft magnetic particles on the isolation system are also analyzed. The results show that the negative stiffness produced by the magnetic force is a major factor affecting the capacity of the isolation system. Compared to devices of the same size, the isolation system equipped with low-particle volume fraction MREs demonstrates better performance.
Dynamic Vibration Absorber with Negative Stiffness for Rotor System
Hongliang Yao
2016-01-01
Full Text Available To suppress the vibration of a rotor system, a vibration absorber combining negative stiffness with positive stiffness together is proposed in this paper. Firstly, the negative stiffness producing mechanism using ring type permanent magnets is presented and the characteristics of the negative stiffness are analyzed. Then, the structure of the absorber is proposed; the principles and nonlinear dynamic characteristics of the absorber-rotor system are studied numerically. Finally, experiments are carried out to verify the numerical conclusions. The results show that the proposed vibration absorber is effective to suppress the vibration of the rotor system, the nonlinearity of the negatives stiffness affects the vibration suppression effect little, and the negative stiffness can broaden the effective vibration control frequency range of the absorber.
ARTERIAL STIFFNESS AND CHRONIC KIDNEY DISEASE: CAUSES AND CONSEQUENCES
J. D. Kobalava
2015-09-01
Full Text Available Chronic kidney disease (CKD is associated with increased cardiovascular risk. CKD is characterized by accelerated aging of vessels in which the age-related arterial stiffness increase is exacerbated by a number of uremia-related processes. Increased arterial stiffness is associated with structural and functional disorders, as well as with the increase in cardiovascular mortality in patients with CKD. Increased arterial stiffness is diagnosed at an early stage of CKD. Modern understanding of the mechanisms of increased risk of cardiovascular complications in CKD, the factors contributing to the loss of elasticity of the arteries, arterial stiffness increase consequences are analyzed. Data illustrating the twoway interaction between CKD and arterial stiffness and mechanisms of accelerated progression of arterial stiffness in CKD are presented.
Stiffness Evolution in Frozen Sands Subjected to Stress Changes
Dai, Sheng
2017-04-21
Sampling affects all soils, including frozen soils and hydrate-bearing sediments. The authors monitor the stiffness evolution of frozen sands subjected to various temperature and stress conditions using an oedometer cell instrumented with P-wave transducers. Experimental results show the stress-dependent stiffness of freshly remolded sands, the dominant stiffening effect of ice, creep after unloading, and the associated exponential decrease in stiffness with time. The characteristic time for stiffness loss during creep is of the order of tens of minutes; therefore it is inevitable that frozen soils experience sampling disturbances attributable to unloading. Slow unloading minimizes stiffness loss; conversely, fast unloading causes a pronounced reduction in stiffness probably attributable to the brittle failure of ice or ice-mineral bonding.
How Does Ankle-foot Orthosis Stiffness Affect Gait in Patients With Lower Limb Salvage?
2014-05-10
tested and between the patient and control groups. Results An increase in AFO compliance resulted in 20% to 26% less knee flexion relative to the...was calculated from the forward progression of a marker on the seventh cervical vertebrae and corresponded to a dimensionless Froude number of 0.16...in a 20% decrease in stance phase knee flexion relative to the nominal strut (p = 0.003) and a 26% decrease relative to the stiff strut (p = 0.001
Uchiyama, Takanori; Saito, Kaito; Shinjo, Katsuya
2015-12-01
The aims of this study were to develop a method to extract the evoked mechanomyogram (MMG) during cycling exercise and to clarify muscle stiffness at various cadences, workloads, and power. Ten young healthy male participants were instructed to pedal a cycle ergometer at cadences of 40 and 60 rpm. The loads were 4.9, 9.8, 14.7, and 19.6 N, respectively. One electrical stimulus per two pedal rotations was applied to the vastus lateralis muscle at a knee angle of 80° in the down phase. MMGs were measured using a capacitor microphone, and the MMGs were divided into stimulated and non-stimulated sequences. Each sequence was synchronously averaged. The synchronously averaged non-stimulated MMG was subtracted from the synchronously averaged stimulated MMG to extract an evoked MMG. The evoked MMG system was identified and the poles of the transfer function were calculated. The poles and mass of the vastus lateralis muscle were used to estimate muscle stiffness. Results showed that muscle stiffness was 186-626 N /m and proportional to the workloads and power. In conclusion, our method can be used to assess muscle stiffness proportional to the workload and power.
Cartesian stiffness matrix of manipulators with passive joints: analytical approach
Pashkevich, Anatoly; Caro, Stéphane; Chablat, Damien
2011-01-01
The paper focuses on stiffness matrix computation for manipulators with passive joints. It proposes both explicit analytical expressions and an efficient recursive procedure that are applicable in general case and allow obtaining the desired matrix either in analytical or numerical form. Advantages of the developed technique and its ability to produce both singular and non-singular stiffness matrices are illustrated by application examples that deal with stiffness modeling of two Stewart-Gough platforms.
Properties of the grasp stiffness matrix and conservative control strategies
Kao, I.; Ngo, C. [State Univ. of New York, Stony Brook, NY (United States)
1999-02-01
In this paper, the authors present fundamental properties of stiffness matrices as applied in analysis of grasping and dexterous manipulation in configuration spaces and linear Euclidean R{sup 3x3} space without rotational components. A conservative-stiffness matrix in such spaces needs to satisfy both symmetric and exact differential criteria. Two types of stiffness matrices are discussed: constant and configuration-dependent matrices are discussed: constant and configuration-dependent matrices. The symmetric part of a constant-stiffness matrix can be derived from a conservative quadratic potential function in the Hermitian form; while the skew-symmetric part is a function of the nonconservative curl vector field of the grasp. A configuration-dependent stiffness matrix needs to be symmetric and must simultaneously satisfy the exact differential condition to be conservative. The theory is most relevant to the Cartesian stiffness control, where the stiffness of the end effector is usually constant, such as that in RCC wrists. Conservative control strategies are proposed for a configuration-dependent stiffness matrix. One of the most important results of this paper is the nonconservative congruence mapping of stiffness between the joint and Cartesian spaces. In general, the congruence transformation (or its inverse transformation), K{sub {theta}} = J{sub {theta}}{sup T}K{sub p}J{sub {theta}}, is a nonconservative mapping over finite paths for a configuration-dependent Jacobian. Thus, to obtain a conservative system with respect to the Cartesian space, one has to either find the corresponding K{sub {theta}} at every configuration due to the constant and symmetric Cartesian stiffness matrix, or determine symmetric yet configuration-varying K{sub {theta}} at every configuration due to the constant and symmetric Cartesian stiffness matrix, or determine the symmetric yet configuration-varying K{sub {theta}} which makes the resulting configuration-dependent K{sub p
Contribution of the transverse arch to foot stiffness in humans
Yawar, Ali; Korpas, Lucia; Lugo-Bolanos, Maria; Mandre, Shreyas; Venkadesan, Madhusudhan
2017-01-01
Stiffness of the human foot is central to its mechanical function, such as elastic energy storage and propulsion. Its doubly-arched structure, manifested as longitudinal and transverse arches, is thought to underlie the stiff nature. However, previous studies have focused solely on the longitudinal arch, and little is known about whether and how the transverse arch impacts the foot's stiffness. The common observation that a flexible currency bill significantly stiffens upon curling it transve...
Stiffness matrix of manipulators with passive joints: computational aspects
Klimchik, Alexandr; Caro, Stéphane; Chablat, Damien; 10.1109/TRO.2012.2187395
2012-01-01
The paper focuses on stiffness matrix computation for manipulators with passive joints, compliant actuators and flexible links. It proposes both explicit analytical expressions and an efficient recursive procedure that are applicable in the general case and allow obtaining the desired matrix either in analytical or numerical form. Advantages of the developed technique and its ability to produce both singular and non-singular stiffness matrices are illustrated by application examples that deal with stiffness modeling of two Stewart-Gough platforms.
Arterial stiffness, hypertension, and rational use of nebivolol
Enrico Agabiti-Rosei
2009-05-01
Full Text Available Enrico Agabiti-Rosei, Enzo Porteri, Damiano RizzoniClinica Medica, Department of Medical and Surgical Sciences, University of Brescia, ItalyAbstract: Arterial stiffness plays a key role in the pathophysiology of the cardiovascular system. Some indices of arterial stiffness (pulse wave velocity, augmentation index, characteristics of central blood pressure waveform may be presently calculated and evaluated in the clinical setting. Age and blood pressure are the two major clinical determinants of increased arterial stiffness, while molecular determinants of arterial stiffness are related to fibrotic components of the extracellular matrix, mainly elastin, collagen and fibronectin. Increased arterial stiffness has been consistently observed in conditions such as hypertension, dyslipidemia and diabetes. Arterial stiffness evaluated by means of carotid-femoral pulse wave velocity yielded prognostic significance beyond and above traditional risk factors. A more favorable effect of calcium channel blockers, diuretics and ACE inhibitors compared with β-blockers on indices of arterial stiffness was observed in several studies. It is conceivable that newer β-blockers with additional vasodilating properties, such as nebivolol, which has favorable effects on carbohydrate and lipid metabolism, as well as on endothelial function and on oxidative stress, may have favorable effects on arterial stiffness, compared with atenolol. In fact, in recent studies, nebivolol was demonstrated to improve artery stiffness to a greater extent than older β-blockers. Because endothelial dysfunction and increased arterial stiffness play an important role in the early atherosclerotic processes and are associated with poor outcomes and increased mortality, independently of blood pressure, the ability of nebivolol to enhance release of endothelium-derived nitric oxide, and consequently improve endothelial function and arterial stiffness, may have significant clinical
Therapeutic modification of arterial stiffness: An update and comprehensive review
Wu, Ching-Fen; Liu, Pang-Yen; Wu, Tsung-Jui; Hung, Yuan; Yang, Shih-Ping; Lin, Gen-Min
2015-01-01
Arterial stiffness has been recognized as a marker of cardiovascular disease and associated with long-term worse clinical outcomes in several populations. Age, hypertension, smoking, and dyslipidemia, known as traditional vascular risk factors, as well as diabetes, obesity, and systemic inflammation lead to both atherosclerosis and arterial stiffness. Targeting multiple modifiable risk factors has become the main therapeutic strategy to improve arterial stiffness in patients at high cardiovas...
Strength and Stiffness Development in Soft Soils: A FESEM aided Soil Microstructure Viewpoint
Wijeyesekera, D. C.; Ho, M. H.; Bai, X.; Bakar, I.
2016-07-01
This paper opens with an overview of the debatable definition of soft soil that goes beyond a (CH) organic / inorganic clay and OH peat to include weakly cemented periglacial deposits of loess and alike. It then outlines the findings obtained from stiffness test on cement-stabilised soft clay. The findings are complemented with a microstructure viewpoint obtained using field emission scanning electron microscope (FESEM). Research also comprised of making cylindrical stabilised clay samples, prepared in the laboratory with various rubber chips contents and cement, and then aged for 28 days. The samples were then subjected to unconfined compressive strength (UCS) test and observations were also made of its microstructure using the FESEM. The impact of the soil microstructure on the stiffness result was studied both with the stabilized soil and also of some of the natural undisturbed loess soils. Sustainability aspect and the potential of the use of rubber chips and sand as additives to cement stabilisation are also discussed. The overall test results indicated that rubber chips and sand contributed to the improvement in unconfined compressive strength (qu). The derogatory influence of moisture on the stiffness of the stabilised clay was studied simultaneously. SEM micrographs are presented that show bonding of cement, rubber chips/ sand and soft clay, granular units and aggregated / agglomerated units in loess. The paper concludes with observations on the dependence of soil microstructure on the soil strength and deformability and even collapsibility of the loess. Current practices adopted as engineering solutions to these challenging soils are outlined.
Low frequency noise reduction using stiff light composite panels
DENG Yongchang; LIN Weizheng
2003-01-01
The experiment presented in this paper is to investigate and analyze the noise reduction at low frequency using stiff light composite panels. Since these composite panels are made of lightweight and stiff materials, this actuation strategy will enable the creation of composite panels for duct noise control without using traditional heavy structural mass. The results suggest that the mass-spring resonance absorption in the case of a comparatively stiff thick panel with a thin flexible plate is more efficient with minimum weight, when subjected to low-frequency (<500 Hz). The efficiency of the panel absorber depends on the mass of the thin flexible plate and the stiffness of the panel.
Tensile Stiffness Analysis on Ocean Dynamic Power Umbilical
汤明刚; 阎军; 王野; 岳前进
2014-01-01
Tensile stiffness of ocean dynamic power umbilical is an important design parameter for functional implementation and structural safety. A column with radial stiffness which is wound by helical steel wires is constructed to predict the tensile stiffness value of umbilicals in the paper. The relationship between the tension and axial deformation is expressed analytically so the radial contraction of the column is achieved in the relationship by use of a simple finite element method. With an agreement between the theoretical prediction and the tension test results, the method is proved to be simple and efficient for the estimation of tensile stiffness of the ocean dynamic power umbilical.
Stiffness Analysis Of Multi-Chain Parallel Robotic Systems
Pashkevich, Anatoly; Chablat, Damien; Wenger, Philippe
2009-01-01
The paper presents a new stiffness modelling method for multi-chain parallel robotic manipulators with flexible links and compliant actuating joints. In contrast to other works, the method involves a FEA-based link stiffness evaluation and employs a new solution strategy of the kinetostatic equations, which allows computing the stiffness matrix for singular postures and to take into account influence of the external forces. The advantages of the developed technique are confirmed by application examples, which deal with stiffness analysis of a parallel manipulator of the Orthoglide family
Stiffness Analysis Of Multi-Chain Parallel Robotic Systems
Pashkevich, Anatoly; Wenger, Philippe
2008-01-01
The paper presents a new stiffness modelling method for multi-chain parallel robotic manipulators with flexible links and compliant actuating joints. In contrast to other works, the method involves a FEA-based link stiffness evaluation and employs a new solution strategy of the kinetostatic equations, which allows computing the stiffness matrix for singular postures and to take into account influence of the internal forces. The advantages of the developed technique are confirmed by application examples, which deal with stiffness analysis of the Orthoglide manipulator.
A novel variable stiffness mechanism for dielectric elastomer actuators
Li, Wen-Bo; Zhang, Wen-Ming; Zou, Hong-Xiang; Peng, Zhi-Ke; Meng, Guang
2017-08-01
In this paper, a novel variable stiffness mechanism is proposed for the design of a variable stiffness dielectric elastomer actuator (VSDEA) which combines a flexible strip with a DEA in a dielectric elastomer minimum energy structure. The DEA induces an analog tuning of the transverse curvature of the strip, thus conveniently providing a voltage-controllable flexural rigidity. The VSDEA tends to be a fully flexible and compact structure with the advantages of simplicity and fast response. Both experimental and theoretical investigations are carried out to reveal the variable stiffness performances of the VSDEA. The effect of the clamped location on the bending stiffness of the VSDEA is analyzed, and then effects of the lengths, the loading points and the applied voltages on the bending stiffness are experimentally investigated. An analytical model is developed to verify the availability of this variable stiffness mechanism, and the theoretical results demonstrate that the bending stiffness of the VSDEA decreases as the applied voltage increases, which agree well with the experimental data. Moreover, the experimental results show that the maximum change of the relative stiffness can reach about 88.80%. It can be useful for the design and optimization of active variable stiffness structures and DEAs for soft robots, vibration control, and morphing applications.
Relationship of rolling bearing stiffness with diameter of roller
郭茂林; 王刚; 张瑞
2002-01-01
The theoretical formula of roller bearing stiffness is induced and compared with its empirical formula.In the experience formula the stiffness of roller bearing has nothing to do with the roller diameter. The relation-ship of roller bearing stiffness with roller diameter was studied using Hz contacting theory. It is concluded thatconclusion in experience formula is only approximate result of data processing under special conditions, and therelation between stiffness of roller bearing and roller diameter must be taken into consideration while designingor selecting roller bearings.
Arterial stiffness: pathophysiology and clinical impact.
London, Gérard M; Marchais, Sylvain J; Guerin, Alain P; Pannier, Bruno
2004-01-01
The ill effects of hypertension are usually attributed to a reduction in the caliber or the number of arterioles, resulting in an increase in total peripheral resistance (TPR). This definition does not take into account the fact that BP is a cyclic phenomenon with systolic and diastolic BP being the limits of these oscillations. The appropriate term to define the arterial factor(s) opposing LV ejection is aortic input impedance which depends on TPR, arterial distensibility (D), and wave reflections (WR). D defines the capacitive properties of arterial stiffness, whose role is to dampen pressure and flow oscillations and to transform pulsatile flow and pressure in arteries into a steady flow and pressure in peripheral tissues. Stiffness is the reciprocal value of D. These parameters are BP dependent, and arteries become stiffer at high pressure. In to D which provides information about the elasticity> of artery as a hollow structure, the elastic incremental modulus (Einc) characterizes the properties of the arterial wall biomaterials, independently of vessel geometry. As an alternative, arterial D can be evaluated by measuring the pulse wave velocity (PWV) which increases with the stiffening of arteries. Arterial stiffening increases left ventricular (LV) afterload and alters the coronary perfusion. With increased PWV, the WR impacts on the aorta during systole, increasing systolic pressures and myocardial oxygen consumption, and decreasing diastolic BP and coronary flow. The arterial stiffness is altered primarily in association with increased collagen content and alterations of extracellular matrix (arteriosclerosis) as classically observed during aging or in arterial hypertension. The arterial stiffening estimated by changes in aortic PWV and intensity of WR are independent predictors of survival in end stage renal disease (ESRD) and general population. Improvement of arterial stiffening could be obtained by antihypertensive treatmen as observed with the calcium
Kochmann, D. M.; Drugan, W. J.
2016-06-01
An elastic system containing a negative-stiffness element tuned to produce positive-infinite system stiffness, although statically unstable as is any such elastic system if unconstrained, is proved to be stabilized by rotation-produced gyroscopic forces at sufficiently high rotation rates. This is accomplished in possibly the simplest model of a composite structure (or solid) containing a negative-stiffness component that exhibits all these features, facilitating a conceptually and mathematically transparent, completely closed-form analysis.
Acute muscular weakness in children
Ricardo Pablo Javier Erazo Torricelli
Full Text Available ABSTRACT Acute muscle weakness in children is a pediatric emergency. During the diagnostic approach, it is crucial to obtain a detailed case history, including: onset of weakness, history of associated febrile states, ingestion of toxic substances/toxins, immunizations, and family history. Neurological examination must be meticulous as well. In this review, we describe the most common diseases related to acute muscle weakness, grouped into the site of origin (from the upper motor neuron to the motor unit. Early detection of hyperCKemia may lead to a myositis diagnosis, and hypokalemia points to the diagnosis of periodic paralysis. Ophthalmoparesis, ptosis and bulbar signs are suggestive of myasthenia gravis or botulism. Distal weakness and hyporeflexia are clinical features of Guillain-Barré syndrome, the most frequent cause of acute muscle weakness. If all studies are normal, a psychogenic cause should be considered. Finding the etiology of acute muscle weakness is essential to execute treatment in a timely manner, improving the prognosis of affected children.
Vichare, Shirish; Sen, Shamik; Inamdar, Mandar M
2014-02-28
Mechanosensing by adherent cells is usually studied by quantifying cell responses on hydrogels that are covalently linked to a rigid substrate. Atomic force microscopy (AFM) represents a convenient way of characterizing the mechanoadaptation response of adherent cells on hydrogels of varying stiffness and thickness. Since AFM measurements reflect the effective cell stiffness, therefore, in addition to measuring real cytoskeletal alterations across different conditions, these measurements might also be influenced by the geometry and physical properties of the substrate itself. To better understand how the physical attributes of the gel influence AFM stiffness measurements of cells, we have used finite element analysis to simulate the indentation of cells of various spreads resting on hydrogels of varying stiffness and thickness. Consistent with experimental results, our simulation results indicate that for well spread cells, stiffness values are significantly over-estimated when experiments are performed on cells cultured on soft and thin gels. Using parametric studies, we have developed scaling relationships between the effective stiffness probed by AFM and the bulk cell stiffness, taking cell and tip geometry, hydrogel properties, nuclear stiffness and cell contractility into account. Finally, using simulated mechanoadaptation responses, we have demonstrated that a cell stiffening response may arise purely due to the substrate properties. Collectively, our results demonstrate the need to take hydrogel properties into account while estimating cell stiffness using AFM indentation.
Discrete computational mechanics for stiff phenomena
Michels, Dominik L.
2016-11-28
Many natural phenomena which occur in the realm of visual computing and computational physics, like the dynamics of cloth, fibers, fluids, and solids as well as collision scenarios are described by stiff Hamiltonian equations of motion, i.e. differential equations whose solution spectra simultaneously contain extremely high and low frequencies. This usually impedes the development of physically accurate and at the same time efficient integration algorithms. We present a straightforward computationally oriented introduction to advanced concepts from classical mechanics. We provide an easy to understand step-by-step introduction from variational principles over the Euler-Lagrange formalism and the Legendre transformation to Hamiltonian mechanics. Based on such solid theoretical foundations, we study the underlying geometric structure of Hamiltonian systems as well as their discrete counterparts in order to develop sophisticated structure preserving integration algorithms to efficiently perform high fidelity simulations.
Determining cantilever stiffness from thermal noise
Jannis Lübbe
2013-03-01
Full Text Available We critically discuss the extraction of intrinsic cantilever properties, namely eigenfrequency fn, quality factor Qn and specifically the stiffness kn of the nth cantilever oscillation mode from thermal noise by an analysis of the power spectral density of displacement fluctuations of the cantilever in contact with a thermal bath. The practical applicability of this approach is demonstrated for several cantilevers with eigenfrequencies ranging from 50 kHz to 2 MHz. As such an analysis requires a sophisticated spectral analysis, we introduce a new method to determine kn from a spectral analysis of the demodulated oscillation signal of the excited cantilever that can be performed in the frequency range of 10 Hz to 1 kHz regardless of the eigenfrequency of the cantilever. We demonstrate that the latter method is in particular useful for noncontact atomic force microscopy (NC-AFM where the required simple instrumentation for spectral analysis is available in most experimental systems.
Vibration control via stiffness switching of magnetostrictive transducers
Scheidler, Justin J.; Asnani, Vivake M.; Dapino, Marcelo J.
2016-04-01
In this paper, a computational study is presented of structural vibration control that is realized by switching a magneto-strictive transducer between high and low stiffness states. Switching is accomplished by either changing the applied magnetic field with a voltage excitation or changing the shunt impedance on the transducer's coil (i.e., the magneto-strictive material's magnetic boundary condition). Switched-stiffness vibration control is simulated using a lumped mass supported by a damper and the magneto-strictive transducer (mount), which is represented by a nonlinear, electromechanical model. Free vibration of the mass is calculated while varying the mount's stiffness according to a reference switched-stiffness vibration control law. The results reveal that switching the magnetic field produces the desired change in stiffness, but also an undesired actuation force that can significantly degrade the vibration control. Hence, a modified switched-stiffness control law that accounts for the actuation force is proposed and implemented for voltage-controlled stiffness switching. The influence of the magneto-mechanical bias condition is also discussed. Voltage-controlled stiffness switching is found to introduce damping equivalent to a viscous damping factor up to about 0.13; this is shown to primarily result from active vibration reduction caused by the actuation force. The merit of magneto-strictive switched-stiffness vibration control is then quantified by comparing the results of voltage- and shunt-controlled stiffness switching to the performance of optimal magneto-strictive shunt damping. For the cases considered, optimal resistive shunt damping performed considerably better than both voltage- and shunt-controlled stiffness switching.
Arterial stiffness, hypertension, and rational use of nebivolol.
Agabiti-Rosei, Enrico; Porteri, Enzo; Rizzoni, Damiano
2009-01-01
Arterial stiffness plays a key role in the pathophysiology of the cardiovascular system. Some indices of arterial stiffness (pulse wave velocity, augmentation index, characteristics of central blood pressure waveform) may be presently calculated and evaluated in the clinical setting. Age and blood pressure are the two major clinical determinants of increased arterial stiffness, while molecular determinants of arterial stiffness are related to fibrotic components of the extracellular matrix, mainly elastin, collagen and fibronectin. Increased arterial stiffness has been consistently observed in conditions such as hypertension, dyslipidemia and diabetes. Arterial stiffness evaluated by means of carotid-femoral pulse wave velocity yielded prognostic significance beyond and above traditional risk factors. A more favorable effect of calcium channel blockers, diuretics and ACE inhibitors compared with beta-blockers on indices of arterial stiffness was observed in several studies. It is conceivable that newer beta-blockers with additional vasodilating properties, such as nebivolol, which has favorable effects on carbohydrate and lipid metabolism, as well as on endothelial function and on oxidative stress, may have favorable effects on arterial stiffness, compared with atenolol. In fact, in recent studies, nebivolol was demonstrated to improve artery stiffness to a greater extent than older beta-blockers. Because endothelial dysfunction and increased arterial stiffness play an important role in the early atherosclerotic processes and are associated with poor outcomes and increased mortality, independently of blood pressure, the ability of nebivolol to enhance release of endothelium-derived nitric oxide, and consequently improve endothelial function and arterial stiffness, may have significant clinical implications for the use of this agent in the treatment of hypertension and cardiovascular diseases.
Arthroscopic capsular release for refractory shoulder stiffness.
Fernandes, Marcos Rassi
2013-01-01
To evaluate the results of the arthroscopic treatment of refractory adhesive capsulitis of the shoulder with two to nine years of follow-up, comparing the pre- and postoperative range of motion. This was an observational study (case series) of 18 patients who underwent arthroscopic capsular release for refractory shoulder stiffness. The mean age was of 53.6 years (range: 39 to 68), with female predominance (77.77%) and nine cases left shoulders. There were 6 primary (33.33%) and 12 secondary cases (66.67%). Arthroscopic capsular release was performed in all patients after a mean of 9.33 months of physical therapy (range: 6 to 20 months) with a minimum follow-up of two years (range: 26 to 110 months). The mean active and passive forward flexion, external rotation and internal rotation increased from 94.4°/103.3°, 11.9°/21.9°, and S1/L5 vertebral level, respectively, to 151.1°/153.8°, 57.2°/64.4°, and T12/T10 vertebral level, respectively. There was a significant difference between the pre- and postoperative range of motion (p < 0.001). According to the Constant-Murley functional score (ROM), the value increased from 14 (preoperative mean) to 30 points (postoperative mean). Postoperatively, all patients showed diminished shoulder pain (none or mild/15 or 10 points in the Constant-Murley score). Arthroscopic treatment is an effective treatment for refractory shoulder stiffness. Copyright © 2013 Elsevier Editora Ltda. All rights reserved.
Clinical Study of Tuina for Stiff Neck
吴耀持; 张峻峰; 汪崇淼; 王健雄; 张沈煜
2009-01-01
Objective: To observe the clinical effect of Tuina for stiffneck. Methods: All of 216 cases with stiff neck were randomly allocated into a tuina group (110 cases) and a control group (106 cases). The patients in the tuina group were treated with "Three Parts, Four Points,Five Manipulation" tuina therapy, while those in the control group were treated with pucturing Wailaogong (Ex-UE 8), Houxi (SI 3), Jianjing (GB 21) and Ashi points in the affected side,Once a day, and 3 times constitute one treatment course. The effect was observed after 2-course treatments. Result: The effective rate in the tuina group and the control group was 93.64% and 83.02%, respectively, and there was statistical difference between the two groups (P < 0.05).Conclusion: The tuina therapy of "Three Parts, Four Points, Five Manipulations" is better than simple acupuncture therapy in treating stiff neck.%目的:观察推拿治疗落枕的临床疗效.方法:将216例落枕患者随机分为推拿组110例和对照组106例,推拿组用"三部四穴五法"推拿法治疗,对照组针刺患侧外劳宫、后溪、肩井和阿是穴.每日1次,3次为1个疗程;治疗2个疗程后观察疗效. 结果:推拿组有效率为93.64%,对照组为83.02%,两者比较有统计学意义(P<0.05)结论:"三部四穴五法"推拿法治疗落枕明显优于单纯针刺疗法.
Symmetry restoration at finite temperature with weak magnetic fields
Navarro, Jorge; Tejeda-Yeomans, Maria Elena; Ayala, Alejandro; Piccinelli, Gabriella
2010-01-01
We study symmetry restoration at finite temperature in the standard model during the electroweak phase transition in the presence of a weak magnetic field. We compute the finite temperature effective potential up to the contribution of ring diagrams, using the broken phase degrees of freedom, and keep track of the gauge parameter dependence of the results. We show that under these conditions, the phase transition becomes stronger first order.
Su, Y.; Teo, S. K.; Tan, R. S.; Lim, C. W.; Zhong, L.
2013-02-01
Ischemic dilated cardiomyopathy (IDCM) is a degenerative disease of the myocardial tissue accompanied by left ventricular (LV) structural changes such as interstitial fibrosis. This can induce increased passive stiffness of the LV wall. However, quantification of LV passive wall stiffness in vivo is extremely difficult, particularly in ventricles with complex geometry. Therefore, we sought to (i) develop a computer-based assessment of LV passive wall stiffness from cardiac magnetic resonance (CMR) imaging in terms of a nominal stiffness index (E*); and (ii) investigate whether E* can offer an insight into cardiac mechanics in IDCM. CMR scans were performed in 5 normal subjects and 5 patients with IDCM. For each data sample, an in-house software was used to generate a 1-to-1 corresponding mesh pair of the LV from the ED and ES phases. The E* values are then computed as a function of local ventricular wall strain. We found that E* in the IDCM group (40.66 - 215.12) was at least one order of magnitude larger than the normal control group (1.00 - 6.14). In addition, the IDCM group revealed much higher inhomogeneity of E* values manifested by a greater spread of E* values throughout the LV. In conclusion, there is a substantial elevated ventricular stiffness index in IDCM. This would suggest that E* could be used as discriminator for early detection of disease state. The computational performance per data sample took approximately 25 seconds, which demonstrates its clinical potential as a real-time cardiac assessment tool.
Effect of joule temperature jump on tension and stiffness of skinned rabbit muscle fibers.
Bershitsky SYu; Tsaturyan, A K
1989-11-01
The effects of a temperature jump (T-jump) from 5-7 degrees C to 26-33 degrees C were studied on tension and stiffness of glycerol-extracted fibers from rabbit psoas muscle in rigor and during maximal Ca2+ activation. The T-jump was initiated by passing an alternating current pulse (30 kHz, up to 2.5 kV, duration 0.2 ms) through a fiber suspended in air. In rigor the T-jump induces a drop of both tension and stiffness. During maximal activation, the immediate stiffness dropped by (4.4 +/- 1.6) x 10(-3)/1 degree C (mean + SD) in response to the T-jump, and this was followed by a monoexponential stiffness rise by a factor of 1.59 +/- 0.14 with a rate constant ks = 174 +/- 42 s-1 (mean +/- SD, n = 8). The data show that the fiber stiffness, determined by the cross-bridge elasticity, in both rigor and maximal activation is not rubber-like. In the activated fibers the T-jump induced a biexponential tension rise by a factor of 3.45 +/- 0.76 (mean +/- SD, n = 8) with the rate constants 500-1,000 s-1 for the first exponent and 167 +/- 39 s-1 (mean +/- SD, n = 8) for the second exponent. The data are in accordance with the assumption that the first phase of the tension transient after the T-jump is due to a force-generating step in the attached cross-bridges, whereas the second one is related to detachment and reattachment of cross-bridges.
... stroke After injury to a nerve During a flare-up of multiple sclerosis (MS) You may feel ... Duchenne) Myotonic dystrophy POISONING Botulism Poisoning ( insecticides , nerve gas) Shellfish poisoning OTHER Not enough healthy red blood ...
High Weak Order Methods for Stochastic Differential Equations Based on Modified Equations
Abdulle, Assyr
2012-01-01
© 2012 Society for Industrial and Applied Mathematics. Inspired by recent advances in the theory of modified differential equations, we propose a new methodology for constructing numerical integrators with high weak order for the time integration of stochastic differential equations. This approach is illustrated with the constructions of new methods of weak order two, in particular, semi-implicit integrators well suited for stiff (meansquare stable) stochastic problems, and implicit integrators that exactly conserve all quadratic first integrals of a stochastic dynamical system. Numerical examples confirm the theoretical results and show the versatility of our methodology.
A Stiffness Estimator for Agonistic-Antagonistic Variable-Stiffness-Actuator Devices
Menard, Tomas; Grioli, Giorgio; Bicchi, Antonio
2014-01-01
International audience; Safe Physical Human Robot Interaction, conservation of energy and adaptability are just the main robotic applications that prompted the development of a number of Variable Stiffness Actuators (VSA). Implemented in a variety of ways, they use various technologies, and feature the most diverse mechanical solutions, all of which share a fundamentally unavoidable nonlinear behavior. The control schemes proposed for these actuators typically aim at independent control of th...
General Torsional Stiffness Matching of Off-road Vehicle
HUANG Song
2009-01-01
Increasing frame torsional stiffness of off-road vehicle will lead to the decrease of body torsional deformation, but the increase of torsional loads of flame and suspension system and the decrease of wheel adhesive weight. In severe case, a certain wheel will be out of contact with road surface. Appropriate matching of body, flame and suspension torsional stiffnesses is a difficult problem for off-road vehicle design. In this paper, these theoretically analytic models of the entire vehicle, body, frame and suspension torsional stiffness are constructed based on the geometry and mechanism of a light off-road vehicle's body, frame and suspension. The body and frame torsional stiffnesses can be calculated by applying body CAE method, meanwhile the suspension's rolling angle stiffness can be obtained by the bench test of the suspension's elastic elements. Through fixing the entire vehicle, using sole timber to raise wheels to simulate the road impact on a certain wheel, the entire vehicle torsional stiffness can be calculated on the geometric relation and loads of testing. Finally some appropriate matching principles of the body, frame and suspension torsional stiffness are summarized according to the test and analysis results. The conclusion can reveal the significance of the suspension torsional stiffness on off-road vehicle's torsion-absorbing capability. The results could serve as a reference for the design of other off-road vehicles.
Mechanically stiff, electrically conductive composites of polymers and carbon nanotubes
Worsley, Marcus A.; Kucheyev, Sergei O.; Baumann, Theodore F.; Kuntz, Joshua D.; Satcher, Jr., Joe H.; Hamza, Alex V.
2015-07-21
Using SWNT-CA as scaffolds to fabricate stiff, highly conductive polymer (PDMS) composites. The SWNT-CA is immersing in a polymer resin to produce a SWNT-CA infiltrated with a polymer resin. The SWNT-CA infiltrated with a polymer resin is cured to produce the stiff and electrically conductive composite of carbon nanotube aerogel and polymer.
Extracellular Matrix Stiffness Regulates Osteogenic Differentiation through MAPK Activation.
Jun-Ha Hwang
Full Text Available Mesenchymal stem cell (MSC differentiation is regulated by the extracellular matrix (ECM through activation of intracellular signaling mediators. The stiffness of the ECM was shown to be an important regulatory factor for MSC differentiation, and transcriptional coactivator with PDZ-binding motif (TAZ was identified as an effector protein for MSC differentiation. However, the detailed underlying mechanism regarding the role of ECM stiffness and TAZ in MSC differentiation is not yet fully understood. In this report, we showed that ECM stiffness regulates MSC fate through ERK or JNK activation. Specifically, a stiff hydrogel matrix stimulates osteogenic differentiation concomitant with increased nuclear localization of TAZ, but inhibits adipogenic differentiation. ERK and JNK activity was significantly increased in cells cultured on a stiff hydrogel. TAZ activation was induced by ERK or JNK activation on a stiff hydrogel because exposure to an ERK or JNK inhibitor significantly decreased the nuclear localization of TAZ, indicating that ECM stiffness-induced ERK or JNK activation is important for TAZ-driven osteogenic differentiation. Taken together, these results suggest that ECM stiffness regulates MSC differentiation through ERK or JNK activation.
Association of Parental Hypertension With Arterial Stiffness in Nonhypertensive Offspring
Andersson, Charlotte; Quiroz, Rene; Enserro, Danielle
2016-01-01
High arterial stiffness seems to be causally involved in the pathogenesis of hypertension. We tested the hypothesis that offspring of parents with hypertension may display higher arterial stiffness before clinically manifest hypertension, given that hypertension is a heritable condition. We compa...
Alcohol intake and aortic stiffness in young men and women
Elzen, A.P. van den; Sierksma, A.; Oren, A.; Vos, L.E.; Witteman, J.C.; Grobbee, D.E.; Hendriks, H.F.; Uiterwaal, C.S.; Bots, M.L.
2005-01-01
Background: Moderate alcohol consumption has been shown to protect against cardiovascular disease. Aortic stiffness can be regarded as a marker of cardiovascular disease risk. Previously we have shown an inverse to J-shaped association between alcohol intake and aortic stiffness in middle-aged and e
Extracellular Matrix Stiffness Regulates Osteogenic Differentiation through MAPK Activation.
Hwang, Jun-Ha; Byun, Mi Ran; Kim, A Rum; Kim, Kyung Min; Cho, Hang Jun; Lee, Yo Han; Kim, Juwon; Jeong, Mi Gyeong; Hwang, Eun Sook; Hong, Jeong-Ho
2015-01-01
Mesenchymal stem cell (MSC) differentiation is regulated by the extracellular matrix (ECM) through activation of intracellular signaling mediators. The stiffness of the ECM was shown to be an important regulatory factor for MSC differentiation, and transcriptional coactivator with PDZ-binding motif (TAZ) was identified as an effector protein for MSC differentiation. However, the detailed underlying mechanism regarding the role of ECM stiffness and TAZ in MSC differentiation is not yet fully understood. In this report, we showed that ECM stiffness regulates MSC fate through ERK or JNK activation. Specifically, a stiff hydrogel matrix stimulates osteogenic differentiation concomitant with increased nuclear localization of TAZ, but inhibits adipogenic differentiation. ERK and JNK activity was significantly increased in cells cultured on a stiff hydrogel. TAZ activation was induced by ERK or JNK activation on a stiff hydrogel because exposure to an ERK or JNK inhibitor significantly decreased the nuclear localization of TAZ, indicating that ECM stiffness-induced ERK or JNK activation is important for TAZ-driven osteogenic differentiation. Taken together, these results suggest that ECM stiffness regulates MSC differentiation through ERK or JNK activation.
A METHOD FOR STIFFNESS MATRIX OF TRIANGULAR TORUS ELEMENT
Durmuş GÜNAY
1996-01-01
Full Text Available The matrices of constants for the stiffness matrices of triangular torus elements family are generated on computer by using the expression given in literature. After the matrices are generated once, it is easy to obtain the stiffness matrices for all member of family of triangular torus elements without need for numerical integration.
Mechanical stiffness: a global parameter associated to elite sprinters performance
Fernando López Mangini
Full Text Available Abstract This study analyzes vertical stiffness as a global parameter that could be directly associated to sprinter's performance. We evaluated vertical stiffness, performance, heart rate and lactate concentration on fifteen male sprinters that ran on a treadmill at gait transition speed and 13 km h−1. Vertical Stiffness was determined by the ratio of the vertical acceleration peak and maximum displacement of the center of mass. Physiological parameters were measured throughout the experimental procedure and performance was estimated by athlete's time records on 100 m track race. As expected, vertical stiffness and heart rate increased with running speed. We found a high correlation between heart rate and vertical stiffness at gait transition speed. However, at 13 km h−1, lactate peak showed a higher correlation with vertical stiffness, suggesting a greater participation of the anaerobic system. An inverse relationship between performance and vertical stiffness was found, where faster athletes were the stiffer ones. Performance and lactate peak presented the same inverse relationship; faster athletes had higher lactate peaks. As a result, faster athletes were stiffer and consume more energy. All in all, these findings suggest that mechanical stiffness could be a potential global parameter to evaluate performance in sprinters.
Modeling and design of energy efficient variable stiffness actuators
Visser, L.C.; Carloni, Raffaella; Ünal, Ramazan; Stramigioli, Stefano
In this paper, we provide a port-based mathematical framework for analyzing and modeling variable stiffness actuators. The framework provides important insights in the energy requirements and, therefore, it is an important tool for the design of energy efficient variable stiffness actuators. Based
Reference values for local arterial stiffness. Part B : femoral artery
Bossuyt, Jelle; Engelen, Lian; Ferreira, Isabel; Stehouwer, Coen D; Boutouyrie, Pierre; Laurent, Stéphane; Segers, Patrick; Reesink, Koen; Van Bortel, Luc M
2015-01-01
OBJECTIVE: Carotid-femoral pulse wave velocity (PWV) is considered the gold standard measure of arterial stiffness, representing mainly aortic stiffness. As compared with the elastic carotid and aorta, the more muscular femoral artery may be differently associated with cardiovascular risk factors (C
叶文江; 王梦莹; 邢红玉; 安亚帅; 秦相磊
2015-01-01
The microwave modulation induced by liquid crystals is determined by the orientation of liquid crystal molecules under an external applied voltage. The anchoring of substrate has an important effect on the liquid crystal orientation, which results in the change of microwave modulation. In this paper, the microwave modulation property of 90◦ twisted nematic liquid crystals with weak anchoring without chiral dopant is studied. Based on the elastic theory of liquid crystals and the variational theory, the equations of equilibrium state and the boundary condition are given, and the variations of phase-shift per unit-length with voltage for different anchoring energy coeﬃcients and pre-tilt angles are also simulated using the finite-difference iterative method. Results are as follows: (1) The influence of pre-tilt angle on microwave phase-shift is related to the applied voltage. When the voltage applied to the liquid crystal cell is from 0.5 to 1.6 V, with increasing pre-tilt angle, the microwave phase-shift per unit-length and the phase-shift difference relative to the strong anchoring 90◦ twisted nematic liquid crystal with pre-tilt angle 0◦ will all increase, and the applied voltage for the maximum phase-shift difference decreases. When the applied voltages are from 1.6 to 3.0 V, the microwave phase-shift per unit-length and the phase-shift difference all decrease with increasing pre-tilt angle. When the applied voltages are near 1.6 V or larger than 3.0 V, the phase-shift per unit-length has little change. (2) The anchoring energy strength has a great influence on microwave phase-shift. As the anchoring strength decreases, the microwave phase shift per unit-length and the phase-shift difference will increase, also the tunable range of microwave phase-shift increases more and more obviously. This research provides a theoretical foundation for the design of the liquid crystal modulator.
Peripheral facial weakness (Bell's palsy).
Basić-Kes, Vanja; Dobrota, Vesna Dermanović; Cesarik, Marijan; Matovina, Lucija Zadro; Madzar, Zrinko; Zavoreo, Iris; Demarin, Vida
2013-06-01
Peripheral facial weakness is a facial nerve damage that results in muscle weakness on one side of the face. It may be idiopathic (Bell's palsy) or may have a detectable cause. Almost 80% of peripheral facial weakness cases are primary and the rest of them are secondary. The most frequent causes of secondary peripheral facial weakness are systemic viral infections, trauma, surgery, diabetes, local infections, tumor, immune disorders, drugs, degenerative diseases of the central nervous system, etc. The diagnosis relies upon the presence of typical signs and symptoms, blood chemistry tests, cerebrospinal fluid investigations, nerve conduction studies and neuroimaging methods (cerebral MRI, x-ray of the skull and mastoid). Treatment of secondary peripheral facial weakness is based on therapy for the underlying disorder, unlike the treatment of Bell's palsy that is controversial due to the lack of large, randomized, controlled, prospective studies. There are some indications that steroids or antiviral agents are beneficial but there are also studies that show no beneficial effect. Additional treatments include eye protection, physiotherapy, acupuncture, botulinum toxin, or surgery. Bell's palsy has a benign prognosis with complete recovery in about 80% of patients, 15% experience some mode of permanent nerve damage and severe consequences remain in 5% of patients.
Khachatryan, Vardan; Tumasyan, Armen; Adam, Wolfgang; Aşılar, Ece; Bergauer, Thomas; Brandstetter, Johannes; Brondolin, Erica; Dragicevic, Marko; Erö, Janos; Flechl, Martin; Friedl, Markus; Fruehwirth, Rudolf; Ghete, Vasile Mihai; Hartl, Christian; Hörmann, Natascha; Hrubec, Josef; Jeitler, Manfred; Knünz, Valentin; König, Axel; Krammer, Manfred; Krätschmer, Ilse; Liko, Dietrich; Matsushita, Takashi; Mikulec, Ivan; Rabady, Dinyar; Rahbaran, Babak; Rohringer, Herbert; Schieck, Jochen; Schöfbeck, Robert; Strauss, Josef; Treberer-Treberspurg, Wolfgang; Waltenberger, Wolfgang; Wulz, Claudia-Elisabeth; Mossolov, Vladimir; Shumeiko, Nikolai; Suarez Gonzalez, Juan; Alderweireldt, Sara; Cornelis, Tom; De Wolf, Eddi A; Janssen, Xavier; Knutsson, Albert; Lauwers, Jasper; Luyckx, Sten; Ochesanu, Silvia; Rougny, Romain; Van De Klundert, Merijn; Van Haevermaet, Hans; Van Mechelen, Pierre; Van Remortel, Nick; Van Spilbeeck, Alex; Abu Zeid, Shimaa; Blekman, Freya; D'Hondt, Jorgen; Daci, Nadir; De Bruyn, Isabelle; Deroover, Kevin; Heracleous, Natalie; Keaveney, James; Lowette, Steven; Moreels, Lieselotte; Olbrechts, Annik; Python, Quentin; Strom, Derek; Tavernier, Stefaan; Van Doninck, Walter; Van Mulders, Petra; Van Onsem, Gerrit Patrick; Van Parijs, Isis; Barria, Patrizia; Brun, Hugues; Caillol, Cécile; Clerbaux, Barbara; De Lentdecker, Gilles; Delannoy, Hugo; Fasanella, Giuseppe; Favart, Laurent; Gay, Arnaud; Grebenyuk, Anastasia; Karapostoli, Georgia; Lenzi, Thomas; Léonard, Alexandre; Maerschalk, Thierry; Marinov, Andrey; Perniè, Luca; Randle-conde, Aidan; Reis, Thomas; Seva, Tomislav; Vander Velde, Catherine; Vanlaer, Pascal; Yonamine, Ryo; Zenoni, Florian; Zhang, Fengwangdong; Beernaert, Kelly; Benucci, Leonardo; Cimmino, Anna; Crucy, Shannon; Dobur, Didar; Fagot, Alexis; Garcia, Guillaume; Gul, Muhammad; Mccartin, Joseph; Ocampo Rios, Alberto Andres; Poyraz, Deniz; Ryckbosch, Dirk; Salva Diblen, Sinem; Sigamani, Michael; Strobbe, Nadja; Tytgat, Michael; Van Driessche, Ward; Yazgan, Efe; Zaganidis, Nicolas; Basegmez, Suzan; Beluffi, Camille; Bondu, Olivier; Brochet, Sébastien; Bruno, Giacomo; Castello, Roberto; Caudron, Adrien; Ceard, Ludivine; Da Silveira, Gustavo Gil; Delaere, Christophe; Favart, Denis; Forthomme, Laurent; Giammanco, Andrea; Hollar, Jonathan; Jafari, Abideh; Jez, Pavel; Komm, Matthias; Lemaitre, Vincent; Mertens, Alexandre; Nuttens, Claude; Perrini, Lucia; Pin, Arnaud; Piotrzkowski, Krzysztof; Popov, Andrey; Quertenmont, Loic; Selvaggi, Michele; Vidal Marono, Miguel; Beliy, Nikita; Hammad, Gregory Habib; Aldá Júnior, Walter Luiz; Alves, Gilvan; Brito, Lucas; Correa Martins Junior, Marcos; Hamer, Matthias; Hensel, Carsten; Mora Herrera, Clemencia; Moraes, Arthur; Pol, Maria Elena; Rebello Teles, Patricia; Belchior Batista Das Chagas, Ewerton; Carvalho, Wagner; Chinellato, Jose; Custódio, Analu; Melo Da Costa, Eliza; De Jesus Damiao, Dilson; De Oliveira Martins, Carley; Fonseca De Souza, Sandro; Huertas Guativa, Lina Milena; Malbouisson, Helena; Matos Figueiredo, Diego; Mundim, Luiz; Nogima, Helio; Prado Da Silva, Wanda Lucia; Santoro, Alberto; Sznajder, Andre; Tonelli Manganote, Edmilson José; Vilela Pereira, Antonio; Ahuja, Sudha; Bernardes, Cesar Augusto; De Souza Santos, Angelo; Dogra, Sunil; Tomei, Thiago; De Moraes Gregores, Eduardo; Mercadante, Pedro G; Moon, Chang-Seong; Novaes, Sergio F; Padula, Sandra; Romero Abad, David; Ruiz Vargas, José Cupertino; Aleksandrov, Aleksandar; Hadjiiska, Roumyana; Iaydjiev, Plamen; Rodozov, Mircho; Stoykova, Stefka; Sultanov, Georgi; Vutova, Mariana; Dimitrov, Anton; Glushkov, Ivan; Litov, Leander; Pavlov, Borislav; Petkov, Peicho; Ahmad, Muhammad; Bian, Jian-Guo; Chen, Guo-Ming; Chen, He-Sheng; Chen, Mingshui; Cheng, Tongguang; Du, Ran; Jiang, Chun-Hua; Plestina, Roko; Romeo, Francesco; Shaheen, Sarmad Masood; Tao, Junquan; Wang, Chunjie; Wang, Zheng; Zhang, Huaqiao; Asawatangtrakuldee, Chayanit; Ban, Yong; Li, Qiang; Liu, Shuai; Mao, Yajun; Qian, Si-Jin; Wang, Dayong; Xu, Zijun; Zou, Wei; Avila, Carlos; Cabrera, Andrés; Chaparro Sierra, Luisa Fernanda; Florez, Carlos; Gomez, Juan Pablo; Gomez Moreno, Bernardo; Sanabria, Juan Carlos; Godinovic, Nikola; Lelas, Damir; Puljak, Ivica; Ribeiro Cipriano, Pedro M; Antunovic, Zeljko; Kovac, Marko; Brigljevic, Vuko; Kadija, Kreso; Luetic, Jelena; Micanovic, Sasa; Sudic, Lucija; Attikis, Alexandros; Mavromanolakis, Georgios; Mousa, Jehad; Nicolaou, Charalambos; Ptochos, Fotios; Razis, Panos A; Rykaczewski, Hans; Bodlak, Martin; Finger, Miroslav; Finger Jr, Michael; El Sawy, Mai
2016-06-10
The CP-violating weak phase $ \\mathrm{ \\phi_s } $ of the $ \\mathrm{ B^0_s } $ meson and the decay width difference $\\Delta \\Gamma_{ \\mathrm{s} }$ of the $ \\mathrm{ B^0_s } $ light and heavy mass eigenstates are measured with the CMS detector at the LHC using a data sample of $ \\mathrm{ B^0_s } \\to \\mathrm{J} / \\psi \\phi(1020) \\to \\mu^+ \\mu^- \\mathrm{ K^{+} K^{-} } $ decays. The analysed data set corresponds to an integrated luminosity of 19.7 fb$^{-1}$ collected in pp collisions at a centre-of-mass energy of 8 TeV. A total of 49 200 reconstructed $ \\mathrm{ B^0_s } $ decays are used to extract the values of $\\mathrm{ \\phi_s }$ and $\\Delta \\Gamma_{ \\mathrm{s} }$ by performing a time-dependent and flavour tagged angular analysis of the $ \\mu^+ \\mu^- \\mathrm{ K^{+} K^{-} } $ final state. The weak phase is measured to be $ \\mathrm{ \\phi_s } = -0.075 \\pm 0.097 \\text{(stat)} \\pm 0.031 \\text{(syst)} $ rad, and the decay width difference is $ \\Delta \\Gamma_{ \\mathrm{s} } = 0.095 \\pm 0.013 \\text{(stat)} \\pm 0.007 \\tex...
Khachatryan, Vardan; Tumasyan, Armen; Adam, Wolfgang; Aşılar, Ece; Bergauer, Thomas; Brandstetter, Johannes; Brondolin, Erica; Dragicevic, Marko; Erö, Janos; Flechl, Martin; Friedl, Markus; Fruehwirth, Rudolf; Ghete, Vasile Mihai; Hartl, Christian; Hörmann, Natascha; Hrubec, Josef; Jeitler, Manfred; Knünz, Valentin; König, Axel; Krammer, Manfred; Krätschmer, Ilse; Liko, Dietrich; Matsushita, Takashi; Mikulec, Ivan; Rabady, Dinyar; Rahbaran, Babak; Rohringer, Herbert; Schieck, Jochen; Schöfbeck, Robert; Strauss, Josef; Treberer-Treberspurg, Wolfgang; Waltenberger, Wolfgang; Wulz, Claudia-Elisabeth; Mossolov, Vladimir; Shumeiko, Nikolai; Suarez Gonzalez, Juan; Alderweireldt, Sara; Cornelis, Tom; De Wolf, Eddi A; Janssen, Xavier; Knutsson, Albert; Lauwers, Jasper; Luyckx, Sten; Ochesanu, Silvia; Rougny, Romain; Van De Klundert, Merijn; Van Haevermaet, Hans; Van Mechelen, Pierre; Van Remortel, Nick; Van Spilbeeck, Alex; Abu Zeid, Shimaa; Blekman, Freya; D'Hondt, Jorgen; Daci, Nadir; De Bruyn, Isabelle; Deroover, Kevin; Heracleous, Natalie; Keaveney, James; Lowette, Steven; Moreels, Lieselotte; Olbrechts, Annik; Python, Quentin; Strom, Derek; Tavernier, Stefaan; Van Doninck, Walter; Van Mulders, Petra; Van Onsem, Gerrit Patrick; Van Parijs, Isis; Barria, Patrizia; Brun, Hugues; Caillol, Cécile; Clerbaux, Barbara; De Lentdecker, Gilles; Delannoy, Hugo; Fasanella, Giuseppe; Favart, Laurent; Gay, Arnaud; Grebenyuk, Anastasia; Karapostoli, Georgia; Lenzi, Thomas; Léonard, Alexandre; Maerschalk, Thierry; Marinov, Andrey; Perniè, Luca; Randle-conde, Aidan; Reis, Thomas; Seva, Tomislav; Vander Velde, Catherine; Vanlaer, Pascal; Yonamine, Ryo; Zenoni, Florian; Zhang, Fengwangdong; Beernaert, Kelly; Benucci, Leonardo; Cimmino, Anna; Crucy, Shannon; Dobur, Didar; Fagot, Alexis; Garcia, Guillaume; Gul, Muhammad; Mccartin, Joseph; Ocampo Rios, Alberto Andres; Poyraz, Deniz; Ryckbosch, Dirk; Salva Diblen, Sinem; Sigamani, Michael; Strobbe, Nadja; Tytgat, Michael; Van Driessche, Ward; Yazgan, Efe; Zaganidis, Nicolas; Basegmez, Suzan; Beluffi, Camille; Bondu, Olivier; Brochet, Sébastien; Bruno, Giacomo; Castello, Roberto; Caudron, Adrien; Ceard, Ludivine; Da Silveira, Gustavo Gil; Delaere, Christophe; Favart, Denis; Forthomme, Laurent; Giammanco, Andrea; Hollar, Jonathan; Jafari, Abideh; Jez, Pavel; Komm, Matthias; Lemaitre, Vincent; Mertens, Alexandre; Nuttens, Claude; Perrini, Lucia; Pin, Arnaud; Piotrzkowski, Krzysztof; Popov, Andrey; Quertenmont, Loic; Selvaggi, Michele; Vidal Marono, Miguel; Beliy, Nikita; Hammad, Gregory Habib; Aldá Júnior, Walter Luiz; Alves, Gilvan; Brito, Lucas; Correa Martins Junior, Marcos; Hamer, Matthias; Hensel, Carsten; Mora Herrera, Clemencia; Moraes, Arthur; Pol, Maria Elena; Rebello Teles, Patricia; Belchior Batista Das Chagas, Ewerton; Carvalho, Wagner; Chinellato, Jose; Custódio, Analu; Da Costa, Eliza Melo; De Jesus Damiao, Dilson; De Oliveira Martins, Carley; Fonseca De Souza, Sandro; Huertas Guativa, Lina Milena; Malbouisson, Helena; Matos Figueiredo, Diego; Mundim, Luiz; Nogima, Helio; Prado Da Silva, Wanda Lucia; Santoro, Alberto; Sznajder, Andre; Tonelli Manganote, Edmilson José; Vilela Pereira, Antonio; Ahuja, Sudha; Bernardes, Cesar Augusto; De Souza Santos, Angelo; Dogra, Sunil; Tomei, Thiago; De Moraes Gregores, Eduardo; Mercadante, Pedro G; Moon, Chang-Seong; Novaes, Sergio F; Padula, Sandra; Romero Abad, David; Ruiz Vargas, José Cupertino; Aleksandrov, Aleksandar; Hadjiiska, Roumyana; Iaydjiev, Plamen; Rodozov, Mircho; Stoykova, Stefka; Sultanov, Georgi; Vutova, Mariana; Dimitrov, Anton; Glushkov, Ivan; Litov, Leander; Pavlov, Borislav; Petkov, Peicho; Ahmad, Muhammad; Bian, Jian-Guo; Chen, Guo-Ming; Chen, He-Sheng; Chen, Mingshui; Cheng, Tongguang; Du, Ran; Jiang, Chun-Hua; Plestina, Roko; Romeo, Francesco; Shaheen, Sarmad Masood; Tao, Junquan; Wang, Chunjie; Wang, Zheng; Zhang, Huaqiao; Asawatangtrakuldee, Chayanit; Ban, Yong; Li, Qiang; Liu, Shuai; Mao, Yajun; Qian, Si-Jin; Wang, Dayong; Xu, Zijun; Zou, Wei; Avila, Carlos; Cabrera, Andrés; Chaparro Sierra, Luisa Fernanda; Florez, Carlos; Gomez, Juan Pablo; Gomez Moreno, Bernardo; Sanabria, Juan Carlos; Godinovic, Nikola; Lelas, Damir; Puljak, Ivica; Ribeiro Cipriano, Pedro M; Antunovic, Zeljko; Kovac, Marko; Brigljevic, Vuko; Kadija, Kreso; Luetic, Jelena; Micanovic, Sasa; Sudic, Lucija; Attikis, Alexandros; Mavromanolakis, Georgios; Mousa, Jehad; Nicolaou, Charalambos; Ptochos, Fotios; Razis, Panos A; Rykaczewski, Hans; Bodlak, Martin; Finger, Miroslav; Finger Jr, Michael; El Sawy, Mai; El-khateeb, Esraa; Elkafrawy, Tamer; Mohamed, Amr; Radi, Amr; Salama, Elsayed; Calpas, Betty; Kadastik, Mario; Murumaa, Marion; Raidal, Martti; Tiko, Andres; Veelken, Christian; Eerola, Paula; Pekkanen, Juska; Voutilainen, Mikko; Härkönen, Jaakko; Jarvinen, Terhi; Karimäki, Veikko; Kinnunen, Ritva; Lampén, Tapio; Lassila-Perini, Kati; Lehti, Sami; Lindén, Tomas; Luukka, Panja-Riina; Mäenpää, Teppo; Peltola, Timo; Tuominen, Eija; Tuominiemi, Jorma; Tuovinen, Esa; Wendland, Lauri; Talvitie, Joonas; Tuuva, Tuure; Besancon, Marc; Couderc, Fabrice; Dejardin, Marc; Denegri, Daniel; Fabbro, Bernard; Faure, Jean-Louis; Favaro, Carlotta; Ferri, Federico; Ganjour, Serguei; Givernaud, Alain; Gras, Philippe; Hamel de Monchenault, Gautier; Jarry, Patrick; Locci, Elizabeth; Machet, Martina; Malcles, Julie; Rander, John; Rosowsky, André; Titov, Maksym; Zghiche, Amina; Antropov, Iurii; Baffioni, Stephanie; Beaudette, Florian; Busson, Philippe; Cadamuro, Luca; Chapon, Emilien; Charlot, Claude; Dahms, Torsten; Davignon, Olivier; Filipovic, Nicolas; Florent, Alice; Granier de Cassagnac, Raphael; Lisniak, Stanislav; Mastrolorenzo, Luca; Miné, Philippe; Naranjo, Ivo Nicolas; Nguyen, Matthew; Ochando, Christophe; Ortona, Giacomo; Paganini, Pascal; Pigard, Philipp; Regnard, Simon; Salerno, Roberto; Sauvan, Jean-Baptiste; Sirois, Yves; Strebler, Thomas; Yilmaz, Yetkin; Zabi, Alexandre; Agram, Jean-Laurent; Andrea, Jeremy; Aubin, Alexandre; Bloch, Daniel; Brom, Jean-Marie; Buttignol, Michael; Chabert, Eric Christian; Chanon, Nicolas; Collard, Caroline; Conte, Eric; Coubez, Xavier; Fontaine, Jean-Charles; Gelé, Denis; Goerlach, Ulrich; Goetzmann, Christophe; Le Bihan, Anne-Catherine; Merlin, Jeremie Alexandre; Skovpen, Kirill; Van Hove, Pierre; Gadrat, Sébastien; Beauceron, Stephanie; Bernet, Colin; Boudoul, Gaelle; Bouvier, Elvire; Carrillo Montoya, Camilo Andres; Chierici, Roberto; Contardo, Didier; Courbon, Benoit; Depasse, Pierre; El Mamouni, Houmani; Fan, Jiawei; Fay, Jean; Gascon, Susan; Gouzevitch, Maxime; Ille, Bernard; Lagarde, Francois; Laktineh, Imad Baptiste; Lethuillier, Morgan; Mirabito, Laurent; Pequegnot, Anne-Laure; Perries, Stephane; Ruiz Alvarez, José David; Sabes, David; Sgandurra, Louis; Sordini, Viola; Vander Donckt, Muriel; Verdier, Patrice; Viret, Sébastien; Xiao, Hong; Toriashvili, Tengizi; Tsamalaidze, Zviad; Autermann, Christian; Beranek, Sarah; Edelhoff, Matthias; Feld, Lutz; Heister, Arno; Kiesel, Maximilian Knut; Klein, Katja; Lipinski, Martin; Ostapchuk, Andrey; Preuten, Marius; Raupach, Frank; Schael, Stefan; Schulte, Jan-Frederik; Verlage, Tobias; Weber, Hendrik; Wittmer, Bruno; Zhukov, Valery; Ata, Metin; Brodski, Michael; Dietz-Laursonn, Erik; Duchardt, Deborah; Endres, Matthias; Erdmann, Martin; Erdweg, Sören; Esch, Thomas; Fischer, Robert; Güth, Andreas; Hebbeker, Thomas; Heidemann, Carsten; Hoepfner, Kerstin; Klingebiel, Dennis; Knutzen, Simon; Kreuzer, Peter; Merschmeyer, Markus; Meyer, Arnd; Millet, Philipp; Olschewski, Mark; Padeken, Klaas; Papacz, Paul; Pook, Tobias; Radziej, Markus; Reithler, Hans; Rieger, Marcel; Scheuch, Florian; Sonnenschein, Lars; Teyssier, Daniel; Thüer, Sebastian; Cherepanov, Vladimir; Erdogan, Yusuf; Flügge, Günter; Geenen, Heiko; Geisler, Matthias; Hoehle, Felix; Kargoll, Bastian; Kress, Thomas; Kuessel, Yvonne; Künsken, Andreas; Lingemann, Joschka; Nehrkorn, Alexander; Nowack, Andreas; Nugent, Ian Michael; Pistone, Claudia; Pooth, Oliver; Stahl, Achim; Aldaya Martin, Maria; Asin, Ivan; Bartosik, Nazar; Behnke, Olaf; Behrens, Ulf; Bell, Alan James; Borras, Kerstin; Burgmeier, Armin; Cakir, Altan; Calligaris, Luigi; Campbell, Alan; Choudhury, Somnath; Costanza, Francesco; Diez Pardos, Carmen; Dolinska, Ganna; Dooling, Samantha; Dorland, Tyler; Eckerlin, Guenter; Eckstein, Doris; Eichhorn, Thomas; Flucke, Gero; Gallo, Elisabetta; Garay Garcia, Jasone; Geiser, Achim; Gizhko, Andrii; Gunnellini, Paolo; Hauk, Johannes; Hempel, Maria; Jung, Hannes; Kalogeropoulos, Alexis; Karacheban, Olena; Kasemann, Matthias; Katsas, Panagiotis; Kieseler, Jan; Kleinwort, Claus; Korol, Ievgen; Lange, Wolfgang; Leonard, Jessica; Lipka, Katerina; Lobanov, Artur; Lohmann, Wolfgang; Mankel, Rainer; Marfin, Ihar; Melzer-Pellmann, Isabell-Alissandra; Meyer, Andreas Bernhard; Mittag, Gregor; Mnich, Joachim; Mussgiller, Andreas; Naumann-Emme, Sebastian; Nayak, Aruna; Ntomari, Eleni; Perrey, Hanno; Pitzl, Daniel; Placakyte, Ringaile; Raspereza, Alexei; Roland, Benoit; Sahin, Mehmet Özgür; Saxena, Pooja; Schoerner-Sadenius, Thomas; Schröder, Matthias; Seitz, Claudia; Spannagel, Simon; Trippkewitz, Karim Damun; Walsh, Roberval; Wissing, Christoph; Blobel, Volker; Centis Vignali, Matteo; Draeger, Arne-Rasmus; Erfle, Joachim; Garutti, Erika; Goebel, Kristin; Gonzalez, Daniel; Görner, Martin; Haller, Johannes; Hoffmann, Malte; Höing, Rebekka Sophie; Junkes, Alexandra; Klanner, Robert; Kogler, Roman; Lapsien, Tobias; Lenz, Teresa; Marchesini, Ivan; Marconi, Daniele; Meyer, Mareike; Nowatschin, Dominik; Ott, Jochen; Pantaleo, Felice; Peiffer, Thomas; Perieanu, Adrian; Pietsch, Niklas; Poehlsen, Jennifer; Rathjens, Denis; Sander, Christian; Schettler, Hannes; Schleper, Peter; Schlieckau, Eike; Schmidt, Alexander; Schwandt, Joern; Seidel, Markus; Sola, Valentina; Stadie, Hartmut; Steinbrück, Georg; Tholen, Heiner; Troendle, Daniel; Usai, Emanuele; Vanelderen, Lukas; Vanhoefer, Annika; Vormwald, Benedikt; Akbiyik, Melike; Barth, Christian; Baus, Colin; Berger, Joram; Böser, Christian; Butz, Erik; Chwalek, Thorsten; Colombo, Fabio; De Boer, Wim; Descroix, Alexis; Dierlamm, Alexander; Fink, Simon; Frensch, Felix; Giffels, Manuel; Gilbert, Andrew; Hartmann, Frank; Heindl, Stefan Michael; Husemann, Ulrich; Katkov, Igor; Kornmayer, Andreas; Lobelle Pardo, Patricia; Maier, Benedikt; Mildner, Hannes; Mozer, Matthias Ulrich; Müller, Thomas; Müller, Thomas; Plagge, Michael; Quast, Gunter; Rabbertz, Klaus; Röcker, Steffen; Roscher, Frank; Simonis, Hans-Jürgen; Stober, Fred-Markus Helmut; Ulrich, Ralf; Wagner-Kuhr, Jeannine; Wayand, Stefan; Weber, Marc; Weiler, Thomas; Wöhrmann, Clemens; Wolf, Roger; Anagnostou, Georgios; Daskalakis, Georgios; Geralis, Theodoros; Giakoumopoulou, Viktoria Athina; Kyriakis, Aristotelis; Loukas, Demetrios; Psallidas, Andreas; Topsis-Giotis, Iasonas; Agapitos, Antonis; Kesisoglou, Stilianos; Panagiotou, Apostolos; Saoulidou, Niki; Tziaferi, Eirini; Evangelou, Ioannis; Flouris, Giannis; Foudas, Costas; Kokkas, Panagiotis; Loukas, Nikitas; Manthos, Nikolaos; Papadopoulos, Ioannis; Paradas, Evangelos; Strologas, John; Bencze, Gyorgy; Hajdu, Csaba; Hazi, Andras; Hidas, Pàl; Horvath, Dezso; Sikler, Ferenc; Veszpremi, Viktor; Vesztergombi, Gyorgy; Zsigmond, Anna Julia; Beni, Noemi; Czellar, Sandor; Karancsi, János; Molnar, Jozsef; Szillasi, Zoltan; Bartók, Márton; Makovec, Alajos; Raics, Peter; Trocsanyi, Zoltan Laszlo; Ujvari, Balazs; Mal, Prolay; Mandal, Koushik; Sahoo, Niladribihari; Swain, Sanjay Kumar; Bansal, Sunil; Beri, Suman Bala; Bhatnagar, Vipin; Chawla, Ridhi; Gupta, Ruchi; Bhawandeep, Bhawandeep; Kalsi, Amandeep Kaur; Kaur, Anterpreet; Kaur, Manjit; Kumar, Ramandeep; Mehta, Ankita; Mittal, Monika; Singh, Jasbir; Walia, Genius; Kumar, Ashok; Bhardwaj, Ashutosh; Choudhary, Brajesh C; Garg, Rocky Bala; Kumar, Ajay; Malhotra, Shivali; Naimuddin, Md; Nishu, Nishu; Ranjan, Kirti; Sharma, Ramkrishna; Sharma, Varun; Banerjee, Sunanda; Bhardwaj, Rishika; Bhattacharya, Satyaki; Chatterjee, Kalyanmoy; Dey, Sourav; Dutta, Suchandra; Jain, Sandhya; Majumdar, Nayana; Modak, Atanu; Mondal, Kuntal; Mukherjee, Swagata; Mukhopadhyay, Supratik; Roy, Ashim; Roy, Debarati; Roy Chowdhury, Suvankar; Sarkar, Subir; Sharan, Manoj; Abdulsalam, Abdulla; Chudasama, Ruchi; Dutta, Dipanwita; Jha, Vishwajeet; Kumar, Vineet; Mohanty, Ajit Kumar; Pant, Lalit Mohan; Shukla, Prashant; Topkar, Anita; Aziz, Tariq; Banerjee, Sudeshna; Bhowmik, Sandeep; Chatterjee, Rajdeep Mohan; Dewanjee, Ram Krishna; Dugad, Shashikant; Ganguly, Sanmay; Ghosh, Saranya; Guchait, Monoranjan; Gurtu, Atul; Kole, Gouranga; Kumar, Sanjeev; Mahakud, Bibhuprasad; Maity, Manas; Majumder, Gobinda; Mazumdar, Kajari; Mitra, Soureek; Mohanty, Gagan Bihari; Parida, Bibhuti; Sarkar, Tanmay; Sudhakar, Katta; Sur, Nairit; Sutar, Bajrang; Wickramage, Nadeesha; Chauhan, Shubhanshu; Dube, Sourabh; Sharma, Seema; Bakhshiansohi, Hamed; Behnamian, Hadi; Etesami, Seyed Mohsen; Fahim, Ali; Goldouzian, Reza; Khakzad, Mohsen; Mohammadi Najafabadi, Mojtaba; Naseri, Mohsen; Paktinat Mehdiabadi, Saeid; Rezaei Hosseinabadi, Ferdos; Safarzadeh, Batool; Zeinali, Maryam; Felcini, Marta; Grunewald, Martin; Abbrescia, Marcello; Calabria, Cesare; Caputo, Claudio; Colaleo, Anna; Creanza, Donato; Cristella, Leonardo; De Filippis, Nicola; De Palma, Mauro; Fiore, Luigi; Iaselli, Giuseppe; Maggi, Giorgio; Maggi, Marcello; Miniello, Giorgia; My, Salvatore; Nuzzo, Salvatore; Pompili, Alexis; Pugliese, Gabriella; Radogna, Raffaella; Ranieri, Antonio; Selvaggi, Giovanna; Silvestris, Lucia; Venditti, Rosamaria; Verwilligen, Piet; Abbiendi, Giovanni; Battilana, Carlo; Benvenuti, Alberto; Bonacorsi, Daniele; Braibant-Giacomelli, Sylvie; Brigliadori, Luca; Campanini, Renato; Capiluppi, Paolo; Castro, Andrea; Cavallo, Francesca Romana; Chhibra, Simranjit Singh; Codispoti, Giuseppe; Cuffiani, Marco; Dallavalle, Gaetano-Marco; Fabbri, Fabrizio; Fanfani, Alessandra; Fasanella, Daniele; Giacomelli, Paolo; Grandi, Claudio; Guiducci, Luigi; Marcellini, Stefano; Masetti, Gianni; Montanari, Alessandro; Navarria, Francesco; Perrotta, Andrea; Rossi, Antonio; Rovelli, Tiziano; Siroli, Gian Piero; Tosi, Nicolò; Travaglini, Riccardo; Cappello, Gigi; Chiorboli, Massimiliano; Costa, Salvatore; Giordano, Ferdinando; Potenza, Renato; Tricomi, Alessia; Tuve, Cristina; Barbagli, Giuseppe; Ciulli, Vitaliano; Civinini, Carlo; D'Alessandro, Raffaello; Focardi, Ettore; Gonzi, Sandro; Gori, Valentina; Lenzi, Piergiulio; Meschini, Marco; Paoletti, Simone; Sguazzoni, Giacomo; Tropiano, Antonio; Viliani, Lorenzo; Benussi, Luigi; Bianco, Stefano; Fabbri, Franco; Piccolo, Davide; Primavera, Federica; Calvelli, Valerio; Ferro, Fabrizio; Lo Vetere, Maurizio; Monge, Maria Roberta; Robutti, Enrico; Tosi, Silvano; Brianza, Luca; Dinardo, Mauro Emanuele; Fiorendi, Sara; Gennai, Simone; Gerosa, Raffaele; Ghezzi, Alessio; Govoni, Pietro; Malvezzi, Sandra; Manzoni, Riccardo Andrea; Marzocchi, Badder; Menasce, Dario; Moroni, Luigi; Paganoni, Marco; Pedrini, Daniele; Ragazzi, Stefano; Redaelli, Nicola; Tabarelli de Fatis, Tommaso; Buontempo, Salvatore; Cavallo, Nicola; Di Guida, Salvatore; Esposito, Marco; Fabozzi, Francesco; Iorio, Alberto Orso Maria; Lanza, Giuseppe; Lista, Luca; Meola, Sabino; Merola, Mario; Paolucci, Pierluigi; Sciacca, Crisostomo; Thyssen, Filip; Azzi, Patrizia; Bacchetta, Nicola; Benato, Lisa; Bisello, Dario; Boletti, Alessio; Carlin, Roberto; Checchia, Paolo; Dall'Osso, Martino; Dorigo, Tommaso; Gasparini, Fabrizio; Gasparini, Ugo; Gonella, Franco; Gozzelino, Andrea; Kanishchev, Konstantin; Lacaprara, Stefano; Margoni, Martino; Maron, Gaetano; Meneguzzo, Anna Teresa; Michelotto, Michele; Pazzini, Jacopo; Pozzobon, Nicola; Ronchese, Paolo; Simonetto, Franco; Torassa, Ezio; Tosi, Mia; Zanetti, Marco; Zotto, Pierluigi; Zucchetta, Alberto; Zumerle, Gianni; Braghieri, Alessandro; Magnani, Alice; Montagna, Paolo; Ratti, Sergio P; Re, Valerio; Riccardi, Cristina; Salvini, Paola; Vai, Ilaria; Vitulo, Paolo; Alunni Solestizi, Luisa; Biasini, Maurizio; Bilei, Gian Mario; Ciangottini, Diego; Fanò, Livio; Lariccia, Paolo; Mantovani, Giancarlo; Menichelli, Mauro; Saha, Anirban; Santocchia, Attilio; Spiezia, Aniello; Androsov, Konstantin; Azzurri, Paolo; Bagliesi, Giuseppe; Bernardini, Jacopo; Boccali, Tommaso; Broccolo, Giuseppe; Castaldi, Rino; Ciocci, Maria Agnese; Dell'Orso, Roberto; Donato, Silvio; Fedi, Giacomo; Foà, Lorenzo; Giassi, Alessandro; Grippo, Maria Teresa; Ligabue, Franco; Lomtadze, Teimuraz; Martini, Luca; Messineo, Alberto; Palla, Fabrizio; Rizzi, Andrea; Savoy-Navarro, Aurore; Serban, Alin Titus; Spagnolo, Paolo; Squillacioti, Paola; Tenchini, Roberto; Tonelli, Guido; Venturi, Andrea; Verdini, Piero Giorgio; Barone, Luciano; Cavallari, Francesca; D'imperio, Giulia; Del Re, Daniele; Diemoz, Marcella; Gelli, Simone; Jorda, Clara; Longo, Egidio; Margaroli, Fabrizio; Meridiani, Paolo; Organtini, Giovanni; Paramatti, Riccardo; Preiato, Federico; Rahatlou, Shahram; Rovelli, Chiara; Santanastasio, Francesco; Traczyk, Piotr; Amapane, Nicola; Arcidiacono, Roberta; Argiro, Stefano; Arneodo, Michele; Bellan, Riccardo; Biino, Cristina; Cartiglia, Nicolo; Costa, Marco; Covarelli, Roberto; Degano, Alessandro; Dellacasa, Giulio; Demaria, Natale; Finco, Linda; Mariotti, Chiara; Maselli, Silvia; Migliore, Ernesto; Monaco, Vincenzo; Monteil, Ennio; Musich, Marco; Obertino, Maria Margherita; Pacher, Luca; Pastrone, Nadia; Pelliccioni, Mario; Pinna Angioni, Gian Luca; Ravera, Fabio; Romero, Alessandra; Ruspa, Marta; Sacchi, Roberto; Solano, Ada; Staiano, Amedeo; Tamponi, Umberto; Belforte, Stefano; Candelise, Vieri; Casarsa, Massimo; Cossutti, Fabio; Della Ricca, Giuseppe; Gobbo, Benigno; La Licata, Chiara; Marone, Matteo; Schizzi, Andrea; Zanetti, Anna; Kropivnitskaya, Anna; Nam, Soon-Kwon; Kim, Dong Hee; Kim, Gui Nyun; Kim, Min Suk; Kong, Dae Jung; Lee, Sangeun; Oh, Young Do; Sakharov, Alexandre; Son, Dong-Chul; Brochero Cifuentes, Javier Andres; Kim, Hyunsoo; Kim, Tae Jeong; Ryu, Min Sang; Song, Sanghyeon; Choi, Suyong; Go, Yeonju; Gyun, Dooyeon; Hong, Byung-Sik; Jo, Mihee; Kim, Hyunchul; Kim, Yongsun; Lee, Byounghoon; Lee, Kisoo; Lee, Kyong Sei; Lee, Songkyo; Park, Sung Keun; Roh, Youn; Yoo, Hwi Dong; Choi, Minkyoo; Kim, Hyunyong; Kim, Ji Hyun; Lee, Jason Sang Hun; Park, Inkyu; Ryu, Geonmo; Choi, Young-Il; Choi, Young Kyu; Goh, Junghwan; Kim, Donghyun; Kwon, Eunhyang; Lee, Jongseok; Yu, Intae; Juodagalvis, Andrius; Vaitkus, Juozas; Ahmed, Ijaz; Ibrahim, Zainol Abidin; Komaragiri, Jyothsna Rani; Md Ali, Mohd Adli Bin; Mohamad Idris, Faridah; Wan Abdullah, Wan Ahmad Tajuddin; Yusli, Mohd Nizam; Casimiro Linares, Edgar; Castilla-Valdez, Heriberto; De La Cruz-Burelo, Eduard; Heredia-De La Cruz, Ivan; Hernandez-Almada, Alberto; Lopez-Fernandez, Ricardo; Sánchez Hernández, Alberto; Carrillo Moreno, Salvador; Vazquez Valencia, Fabiola; Pedraza, Isabel; Salazar Ibarguen, Humberto Antonio; Morelos Pineda, Antonio; Krofcheck, David; Butler, Philip H; Ahmad, Ashfaq; Ahmad, Muhammad; Hassan, Qamar; Hoorani, Hafeez R; Khan, Wajid Ali; Khurshid, Taimoor; Shoaib, Muhammad; Bialkowska, Helena; Bluj, Michal; Boimska, Bożena; Frueboes, Tomasz; Górski, Maciej; Kazana, Malgorzata; Nawrocki, Krzysztof; Romanowska-Rybinska, Katarzyna; Szleper, Michal; Zalewski, Piotr; Brona, Grzegorz; Bunkowski, Karol; Doroba, Krzysztof; Kalinowski, Artur; Konecki, Marcin; Krolikowski, Jan; Misiura, Maciej; Olszewski, Michal; Walczak, Marek; Bargassa, Pedrame; Beirão Da Cruz E Silva, Cristóvão; Di Francesco, Agostino; Faccioli, Pietro; Ferreira Parracho, Pedro Guilherme; Gallinaro, Michele; Leonardo, Nuno; Lloret Iglesias, Lara; Nguyen, Federico; Rodrigues Antunes, Joao; Seixas, Joao; Toldaiev, Oleksii; Vadruccio, Daniele; Varela, Joao; Vischia, Pietro; Afanasiev, Serguei; Bunin, Pavel; Gavrilenko, Mikhail; Golutvin, Igor; Gorbunov, Ilya; Kamenev, Alexey; Karjavin, Vladimir; Konoplyanikov, Viktor; Lanev, Alexander; Malakhov, Alexander; Matveev, Viktor; Moisenz, Petr; Palichik, Vladimir; Perelygin, Victor; Shmatov, Sergey; Shulha, Siarhei; Skatchkov, Nikolai; Smirnov, Vitaly; Zarubin, Anatoli; Golovtsov, Victor; Ivanov, Yury; Kim, Victor; Kuznetsova, Ekaterina; Levchenko, Petr; Murzin, Victor; Oreshkin, Vadim; Smirnov, Igor; Sulimov, Valentin; Uvarov, Lev; Vavilov, Sergey; Vorobyev, Alexey; Andreev, Yuri; Dermenev, Alexander; Gninenko, Sergei; Golubev, Nikolai; Karneyeu, Anton; Kirsanov, Mikhail; Krasnikov, Nikolai; Pashenkov, Anatoli; Tlisov, Danila; Toropin, Alexander; Epshteyn, Vladimir; Gavrilov, Vladimir; Lychkovskaya, Natalia; Popov, Vladimir; Pozdnyakov, Ivan; Safronov, Grigory; Spiridonov, Alexander; Vlasov, Evgueni; Zhokin, Alexander; Bylinkin, Alexander; Andreev, Vladimir; Azarkin, Maksim; Dremin, Igor; Kirakosyan, Martin; Leonidov, Andrey; Mesyats, Gennady; Rusakov, Sergey V; Vinogradov, Alexey; Baskakov, Alexey; Belyaev, Andrey; Boos, Edouard; Dubinin, Mikhail; Dudko, Lev; Ershov, Alexander; Gribushin, Andrey; Klyukhin, Vyacheslav; Kodolova, Olga; Lokhtin, Igor; Myagkov, Igor; Obraztsov, Stepan; Petrushanko, Sergey; Savrin, Viktor; Snigirev, Alexander; Azhgirey, Igor; Bayshev, Igor; Bitioukov, Sergei; Kachanov, Vassili; Kalinin, Alexey; Konstantinov, Dmitri; Krychkine, Victor; Petrov, Vladimir; Ryutin, Roman; Sobol, Andrei; Tourtchanovitch, Leonid; Troshin, Sergey; Tyurin, Nikolay; Uzunian, Andrey; Volkov, Alexey; Adzic, Petar; Ekmedzic, Marko; Milosevic, Jovan; Rekovic, Vladimir; Alcaraz Maestre, Juan; Calvo, Enrique; Cerrada, Marcos; Chamizo Llatas, Maria; Colino, Nicanor; De La Cruz, Begona; Delgado Peris, Antonio; Domínguez Vázquez, Daniel; Escalante Del Valle, Alberto; Fernandez Bedoya, Cristina; Fernández Ramos, Juan Pablo; Flix, Jose; Fouz, Maria Cruz; Garcia-Abia, Pablo; Gonzalez Lopez, Oscar; Goy Lopez, Silvia; Hernandez, Jose M; Josa, Maria Isabel; Navarro De Martino, Eduardo; Pérez-Calero Yzquierdo, Antonio María; Puerta Pelayo, Jesus; Quintario Olmeda, Adrián; Redondo, Ignacio; Romero, Luciano; Soares, Mara Senghi; Albajar, Carmen; de Trocóniz, Jorge F; Missiroli, Marino; Moran, Dermot; Cuevas, Javier; Fernandez Menendez, Javier; Folgueras, Santiago; Gonzalez Caballero, Isidro; Palencia Cortezon, Enrique; Vizan Garcia, Jesus Manuel; Cabrillo, Iban Jose; Calderon, Alicia; Castiñeiras De Saa, Juan Ramon; De Castro Manzano, Pablo; Duarte Campderros, Jordi; Fernandez, Marcos; Garcia-Ferrero, Juan; Gomez, Gervasio; Lopez Virto, Amparo; Marco, Jesus; Marco, Rafael; Martinez Rivero, Celso; Matorras, Francisco; Munoz Sanchez, Francisca Javiela; Piedra Gomez, Jonatan; Rodrigo, Teresa; Rodríguez-Marrero, Ana Yaiza; Ruiz-Jimeno, Alberto; Scodellaro, Luca; Vila, Ivan; Vilar Cortabitarte, Rocio; Abbaneo, Duccio; Auffray, Etiennette; Auzinger, Georg; Bachtis, Michail; Baillon, Paul; Ball, Austin; Barney, David; Benaglia, Andrea; Bendavid, Joshua; Benhabib, Lamia; Benitez, Jose F; Berruti, Gaia Maria; Bloch, Philippe; Bocci, Andrea; Bonato, Alessio; Botta, Cristina; Breuker, Horst; Camporesi, Tiziano; Cerminara, Gianluca; Colafranceschi, Stefano; D'Alfonso, Mariarosaria; D'Enterria, David; Dabrowski, Anne; Daponte, Vincenzo; David Tinoco Mendes, Andre; De Gruttola, Michele; De Guio, Federico; De Roeck, Albert; De Visscher, Simon; Di Marco, Emanuele; Dobson, Marc; Dordevic, Milos; Dorney, Brian; Du Pree, Tristan; Dünser, Marc; Dupont, Niels; Elliott-Peisert, Anna; Franzoni, Giovanni; Funk, Wolfgang; Gigi, Dominique; Gill, Karl; Giordano, Domenico; Girone, Maria; Glege, Frank; Guida, Roberto; Gundacker, Stefan; Guthoff, Moritz; Hammer, Josef; Harris, Philip; Hegeman, Jeroen; Innocente, Vincenzo; Janot, Patrick; Kirschenmann, Henning; Kortelainen, Matti J; Kousouris, Konstantinos; Krajczar, Krisztian; Lecoq, Paul; Lourenco, Carlos; Lucchini, Marco Toliman; Magini, Nicolo; Malgeri, Luca; Mannelli, Marcello; Martelli, Arabella; Masetti, Lorenzo; Meijers, Frans; Mersi, Stefano; Meschi, Emilio; Moortgat, Filip; Morovic, Srecko; Mulders, Martijn; Nemallapudi, Mythra Varun; Neugebauer, Hannes; Orfanelli, Styliani; Orsini, Luciano; Pape, Luc; Perez, Emmanuelle; Peruzzi, Marco; Petrilli, Achille; Petrucciani, Giovanni; Pfeiffer, Andreas; Piparo, Danilo; Racz, Attila; Rolandi, Gigi; Rovere, Marco; Ruan, Manqi; Sakulin, Hannes; Schäfer, Christoph; Schwick, Christoph; Sharma, Archana; Silva, Pedro; Simon, Michal; Sphicas, Paraskevas; Spiga, Daniele; Steggemann, Jan; Stieger, Benjamin; Stoye, Markus; Takahashi, Yuta; Treille, Daniel; Triossi, Andrea; Tsirou, Andromachi; Veres, Gabor Istvan; Wardle, Nicholas; Wöhri, Hermine Katharina; Zagoździńska, Agnieszka; Zeuner, Wolfram Dietrich; Bertl, Willi; Deiters, Konrad; Erdmann, Wolfram; Horisberger, Roland; Ingram, Quentin; Kaestli, Hans-Christian; Kotlinski, Danek; Langenegger, Urs; Renker, Dieter; Rohe, Tilman; Bachmair, Felix; Bäni, Lukas; Bianchini, Lorenzo; Buchmann, Marco-Andrea; Casal, Bruno; Dissertori, Günther; Dittmar, Michael; Donegà, Mauro; Eller, Philipp; Grab, Christoph; Heidegger, Constantin; Hits, Dmitry; Hoss, Jan; Kasieczka, Gregor; Lustermann, Werner; Mangano, Boris; Marionneau, Matthieu; Martinez Ruiz del Arbol, Pablo; Masciovecchio, Mario; Meister, Daniel; Micheli, Francesco; Musella, Pasquale; Nessi-Tedaldi, Francesca; Pandolfi, Francesco; Pata, Joosep; Pauss, Felicitas; Perrozzi, Luca; Quittnat, Milena; Rossini, Marco; Starodumov, Andrei; Takahashi, Maiko; Tavolaro, Vittorio Raoul; Theofilatos, Konstantinos; Wallny, Rainer; Aarrestad, Thea Klaeboe; Amsler, Claude; Caminada, Lea; Canelli, Maria Florencia; Chiochia, Vincenzo; De Cosa, Annapaola; Galloni, Camilla; Hinzmann, Andreas; Hreus, Tomas; Kilminster, Benjamin; Lange, Clemens; Ngadiuba, Jennifer; Pinna, Deborah; Robmann, Peter; Ronga, Frederic Jean; Salerno, Daniel; Yang, Yong; Cardaci, Marco; Chen, Kuan-Hsin; Doan, Thi Hien; Jain, Shilpi; Khurana, Raman; Konyushikhin, Maxim; Kuo, Chia-Ming; Lin, Willis; Lu, Yun-Ju; Yu, Shin-Shan; Kumar, Arun; Bartek, Rachel; Chang, Paoti; Chang, You-Hao; Chang, Yu-Wei; Chao, Yuan; Chen, Kai-Feng; Chen, Po-Hsun; Dietz, Charles; Fiori, Francesco; Grundler, Ulysses; Hou, George Wei-Shu; Hsiung, Yee; Liu, Yueh-Feng; Lu, Rong-Shyang; Miñano Moya, Mercedes; Petrakou, Eleni; Tsai, Jui-fa; Tzeng, Yeng-Ming; Asavapibhop, Burin; Kovitanggoon, Kittikul; Singh, Gurpreet; Srimanobhas, Norraphat; Suwonjandee, Narumon; Adiguzel, Aytul; Cerci, Salim; Demiroglu, Zuhal Seyma; Dozen, Candan; Girgis, Semiray; Gokbulut, Gul; Guler, Yalcin; Gurpinar, Emine; Hos, Ilknur; Kangal, Evrim Ersin; Kayis Topaksu, Aysel; Onengut, Gulsen; Ozdemir, Kadri; Ozturk, Sertac; Tali, Bayram; Topakli, Huseyin; Vergili, Mehmet; Zorbilmez, Caglar; Akin, Ilina Vasileva; Bilin, Bugra; Bilmis, Selcuk; Isildak, Bora; Karapinar, Guler; Yalvac, Metin; Zeyrek, Mehmet; Yetkin, Elif Asli; Gülmez, Erhan; Kaya, Mithat; Kaya, Ozlem; Yetkin, Taylan; Cankocak, Kerem; Sen, Sercan; Vardarlı, Fuat Ilkehan; Grynyov, Boris; Levchuk, Leonid; Sorokin, Pavel; Aggleton, Robin; Ball, Fionn; Beck, Lana; Brooke, James John; Clement, Emyr; Cussans, David; Flacher, Henning; Goldstein, Joel; Grimes, Mark; Heath, Greg P; Heath, Helen F; Jacob, Jeson; Kreczko, Lukasz; Lucas, Chris; Meng, Zhaoxia; Newbold, Dave M; Paramesvaran, Sudarshan; Poll, Anthony; Sakuma, Tai; Seif El Nasr-storey, Sarah; Senkin, Sergey; Smith, Dominic; Smith, Vincent J; Barducci, Daniele; Bell, Ken W; Belyaev, Alexander; Brew, Christopher; Brown, Robert M; Cieri, Davide; Cockerill, David JA; Coughlan, John A; Harder, Kristian; Harper, Sam; Olaiya, Emmanuel; Petyt, David; Shepherd-Themistocleous, Claire; Thea, Alessandro; Thomas, Laurent; Tomalin, Ian R; Williams, Thomas; Womersley, William John; Worm, Steven; Baber, Mark; Bainbridge, Robert; Buchmuller, Oliver; Bundock, Aaron; Burton, Darren; Casasso, Stefano; Citron, Matthew; Colling, David; Corpe, Louie; Cripps, Nicholas; Dauncey, Paul; Davies, Gavin; De Wit, Adinda; Della Negra, Michel; Dunne, Patrick; Elwood, Adam; Ferguson, William; Fulcher, Jonathan; Futyan, David; Hall, Geoffrey; Iles, Gregory; Kenzie, Matthew; Lane, Rebecca; Lucas, Robyn; Lyons, Louis; Magnan, Anne-Marie; Malik, Sarah; Nash, Jordan; Nikitenko, Alexander; Pela, Joao; Pesaresi, Mark; Petridis, Konstantinos; Raymond, David Mark; Richards, Alexander; Rose, Andrew; Seez, Christopher; Tapper, Alexander; 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Tadel, Matevz; Vartak, Adish; Wasserbaech, Steven; Welke, Charles; Würthwein, Frank; Yagil, Avraham; Zevi Della Porta, Giovanni; Barge, Derek; Bradmiller-Feld, John; Campagnari, Claudio; Dishaw, Adam; Dutta, Valentina; Flowers, Kristen; Franco Sevilla, Manuel; Geffert, Paul; George, Christopher; Golf, Frank; Gouskos, Loukas; Gran, Jason; Incandela, Joe; Justus, Christopher; Mccoll, Nickolas; Mullin, Sam Daniel; Richman, Jeffrey; Stuart, David; Suarez, Indara; To, Wing; West, Christopher; Yoo, Jaehyeok; Anderson, Dustin; Apresyan, Artur; Bornheim, Adolf; Bunn, Julian; Chen, Yi; Duarte, Javier; Mott, Alexander; Newman, Harvey B; Pena, Cristian; Pierini, Maurizio; Spiropulu, Maria; Vlimant, Jean-Roch; Xie, Si; Zhu, Ren-Yuan; Andrews, Michael Benjamin; Azzolini, Virginia; Calamba, Aristotle; Carlson, Benjamin; Ferguson, Thomas; Paulini, Manfred; Russ, James; Sun, Menglei; Vogel, Helmut; Vorobiev, Igor; Cumalat, John Perry; Ford, William T; Gaz, Alessandro; Jensen, Frank; Johnson, Andrew; Krohn, Michael; Mulholland, Troy; Nauenberg, Uriel; Stenson, Kevin; Wagner, Stephen Robert; Alexander, James; Chatterjee, Avishek; Chaves, Jorge; Chu, Jennifer; Dittmer, Susan; Eggert, Nicholas; Mirman, Nathan; Nicolas Kaufman, Gala; Patterson, Juliet Ritchie; Rinkevicius, Aurelijus; Ryd, Anders; Skinnari, Louise; Soffi, Livia; Sun, Werner; Tan, Shao Min; Teo, Wee Don; Thom, Julia; Thompson, Joshua; Tucker, Jordan; Weng, Yao; Wittich, Peter; Abdullin, Salavat; Albrow, Michael; Anderson, Jacob; Apollinari, Giorgio; Bauerdick, Lothar AT; Beretvas, Andrew; Berryhill, Jeffrey; Bhat, Pushpalatha C; Bolla, Gino; Burkett, Kevin; Butler, Joel Nathan; Cheung, Harry; Chlebana, Frank; Cihangir, Selcuk; Elvira, Victor Daniel; Fisk, Ian; Freeman, Jim; Gottschalk, Erik; Gray, Lindsey; Green, Dan; Grünendahl, Stefan; Gutsche, Oliver; Hanlon, Jim; Hare, Daryl; Harris, Robert M; Hirschauer, James; Hu, Zhen; Jindariani, Sergo; Johnson, Marvin; Joshi, Umesh; Jung, Andreas Werner; Klima, Boaz; Kreis, Benjamin; Kwan, Simon; Lammel, Stephan; Linacre, Jacob; Lincoln, Don; Lipton, Ron; Liu, Tiehui; Lopes De Sá, Rafael; Lykken, Joseph; Maeshima, Kaori; Marraffino, John Michael; Martinez Outschoorn, Verena Ingrid; Maruyama, Sho; Mason, David; McBride, Patricia; Merkel, Petra; Mishra, Kalanand; Mrenna, Stephen; Nahn, Steve; Newman-Holmes, Catherine; O'Dell, Vivian; Pedro, Kevin; Prokofyev, Oleg; Rakness, Gregory; Sexton-Kennedy, Elizabeth; Soha, Aron; Spalding, William J; Spiegel, Leonard; Taylor, Lucas; Tkaczyk, Slawek; Tran, Nhan Viet; Uplegger, Lorenzo; Vaandering, Eric Wayne; Vernieri, Caterina; Verzocchi, Marco; Vidal, Richard; Weber, Hannsjoerg Artur; Whitbeck, Andrew; Yang, Fan; Acosta, Darin; Avery, Paul; Bortignon, Pierluigi; Bourilkov, Dimitri; Carnes, Andrew; Carver, Matthew; Curry, David; Das, Souvik; Di Giovanni, Gian Piero; Field, Richard D; Furic, Ivan-Kresimir; Hugon, Justin; Konigsberg, Jacobo; Korytov, Andrey; Low, Jia Fu; Ma, Peisen; Matchev, Konstantin; Mei, Hualin; Milenovic, Predrag; Mitselmakher, Guenakh; Rank, Douglas; Rossin, Roberto; Shchutska, Lesya; Snowball, Matthew; Sperka, David; Terentyev, Nikolay; Wang, Jian; Wang, Sean-Jiun; Yelton, John; Hewamanage, Samantha; Linn, Stephan; Markowitz, Pete; Martinez, German; Rodriguez, Jorge Luis; Ackert, Andrew; Adams, Jordon Rowe; Adams, Todd; Askew, Andrew; Bochenek, Joseph; Diamond, Brendan; Haas, Jeff; Hagopian, Sharon; Hagopian, Vasken; Johnson, Kurtis F; Khatiwada, Ajeeta; Prosper, Harrison; Veeraraghavan, Venkatesh; Weinberg, Marc; Baarmand, Marc M; Bhopatkar, Vallary; Hohlmann, Marcus; Kalakhety, Himali; Noonan, Daniel; Roy, Titas; Yumiceva, Francisco; Adams, Mark Raymond; Apanasevich, Leonard; Berry, Douglas; Betts, Russell Richard; Bucinskaite, Inga; Cavanaugh, Richard; Evdokimov, Olga; Gauthier, Lucie; Gerber, Cecilia Elena; Hofman, David Jonathan; Kurt, Pelin; O'Brien, Christine; Sandoval Gonzalez, Irving Daniel; Silkworth, Christopher; Turner, Paul; Varelas, Nikos; Wu, Zhenbin; Zakaria, Mohammed; Bilki, Burak; Clarida, Warren; Dilsiz, Kamuran; Durgut, Süleyman; Gandrajula, Reddy Pratap; Haytmyradov, Maksat; Khristenko, Viktor; Merlo, Jean-Pierre; Mermerkaya, Hamit; Mestvirishvili, Alexi; Moeller, Anthony; Nachtman, Jane; Ogul, Hasan; Onel, Yasar; Ozok, Ferhat; Penzo, Aldo; Snyder, Christina; Tan, Ping; Tiras, Emrah; Wetzel, James; Yi, Kai; Anderson, Ian; Barnett, Bruce Arnold; Blumenfeld, Barry; Fehling, David; Feng, Lei; Gritsan, Andrei; Maksimovic, Petar; Martin, Christopher; Osherson, Marc; Swartz, Morris; Xiao, Meng; Xin, Yongjie; You, Can; Baringer, Philip; Bean, Alice; Benelli, Gabriele; Bruner, Christopher; Kenny III, Raymond Patrick; Majumder, Devdatta; Malek, Magdalena; Murray, Michael; Sanders, Stephen; Stringer, Robert; Wang, Quan; Ivanov, Andrew; Kaadze, Ketino; Khalil, Sadia; Makouski, Mikhail; Maravin, Yurii; Mohammadi, Abdollah; Saini, Lovedeep Kaur; Skhirtladze, Nikoloz; Toda, Sachiko; Lange, David; Rebassoo, Finn; Wright, Douglas; Anelli, Christopher; Baden, Drew; Baron, Owen; Belloni, Alberto; Calvert, Brian; Eno, Sarah Catherine; Ferraioli, Charles; Gomez, Jaime; Hadley, Nicholas John; Jabeen, Shabnam; Kellogg, Richard G; Kolberg, Ted; Kunkle, Joshua; Lu, Ying; Mignerey, Alice; Shin, Young Ho; Skuja, Andris; Tonjes, Marguerite; Tonwar, Suresh C; Apyan, Aram; Barbieri, Richard; Baty, Austin; Bierwagen, Katharina; Brandt, Stephanie; Busza, Wit; Cali, Ivan Amos; Demiragli, Zeynep; Di Matteo, Leonardo; Gomez Ceballos, Guillelmo; Goncharov, Maxim; Gulhan, Doga; Iiyama, Yutaro; Innocenti, Gian Michele; Klute, Markus; Kovalskyi, Dmytro; Lai, Yue Shi; Lee, Yen-Jie; Levin, Andrew; Luckey, Paul David; Marini, Andrea Carlo; Mcginn, Christopher; Mironov, Camelia; Niu, Xinmei; Paus, Christoph; Ralph, Duncan; Roland, Christof; Roland, Gunther; Salfeld-Nebgen, Jakob; Stephans, George; Sumorok, Konstanty; Varma, Mukund; Velicanu, Dragos; Veverka, Jan; Wang, Jing; Wang, Ta-Wei; Wyslouch, Bolek; Yang, Mingming; Zhukova, Victoria; Dahmes, Bryan; Finkel, Alexey; Gude, Alexander; Hansen, Peter; Kalafut, Sean; Kao, Shih-Chuan; Klapoetke, Kevin; Kubota, Yuichi; Lesko, Zachary; Mans, Jeremy; Nourbakhsh, Shervin; Ruckstuhl, Nicole; Rusack, Roger; Tambe, Norbert; Turkewitz, Jared; Acosta, John Gabriel; Oliveros, Sandra; Avdeeva, Ekaterina; Bloom, Kenneth; Bose, Suvadeep; Claes, Daniel R; Dominguez, Aaron; Fangmeier, Caleb; Gonzalez Suarez, Rebeca; Kamalieddin, Rami; Keller, Jason; Knowlton, Dan; Kravchenko, Ilya; Lazo-Flores, Jose; Meier, Frank; Monroy, Jose; Ratnikov, Fedor; Siado, Joaquin Emilo; Snow, Gregory R; Alyari, Maral; Dolen, James; George, Jimin; Godshalk, Andrew; Harrington, Charles; Iashvili, Ia; Kaisen, Josh; Kharchilava, Avto; Kumar, Ashish; Rappoccio, Salvatore; Alverson, George; Barberis, Emanuela; Baumgartel, Darin; Chasco, Matthew; Hortiangtham, Apichart; Massironi, Andrea; Morse, David Michael; Nash, David; Orimoto, Toyoko; Teixeira De Lima, Rafael; Trocino, Daniele; Wang, Ren-Jie; Wood, Darien; Zhang, Jinzhong; Hahn, Kristan Allan; Kubik, Andrew; Mucia, Nicholas; Odell, Nathaniel; Pollack, Brian; Pozdnyakov, Andrey; Schmitt, Michael; Stoynev, Stoyan; Sung, Kevin; Trovato, Marco; Velasco, Mayda; Brinkerhoff, Andrew; Dev, Nabarun; Hildreth, Michael; Jessop, Colin; Karmgard, Daniel John; Kellams, Nathan; Lannon, Kevin; Lynch, Sean; Marinelli, Nancy; Meng, Fanbo; Mueller, Charles; Musienko, Yuri; Pearson, Tessa; Planer, Michael; Reinsvold, Allison; Ruchti, Randy; Smith, Geoffrey; Taroni, Silvia; Valls, Nil; Wayne, Mitchell; Wolf, Matthias; Woodard, Anna; Antonelli, Louis; Brinson, Jessica; Bylsma, Ben; Durkin, Lloyd Stanley; Flowers, Sean; Hart, Andrew; Hill, Christopher; Hughes, Richard; Ji, Weifeng; Kotov, Khristian; Ling, Ta-Yung; Liu, Bingxuan; Luo, Wuming; Puigh, Darren; Rodenburg, Marissa; Winer, Brian L; Wulsin, Howard Wells; Driga, Olga; Elmer, Peter; Hardenbrook, Joshua; Hebda, Philip; Koay, Sue Ann; Lujan, Paul; Marlow, Daniel; Medvedeva, Tatiana; Mooney, Michael; Olsen, James; Palmer, Christopher; Piroué, Pierre; Quan, Xiaohang; Saka, Halil; Stickland, David; Tully, Christopher; Werner, Jeremy Scott; Zuranski, Andrzej; Malik, Sudhir; Barnes, Virgil E; Benedetti, Daniele; Bortoletto, Daniela; Gutay, Laszlo; Jha, Manoj; Jones, Matthew; Jung, Kurt; Kress, Matthew; Miller, David Harry; Neumeister, Norbert; Radburn-Smith, Benjamin Charles; Shi, Xin; Shipsey, Ian; Silvers, David; Sun, Jian; Svyatkovskiy, Alexey; Wang, Fuqiang; Xie, Wei; Xu, Lingshan; Parashar, Neeti; Stupak, John; Adair, Antony; Akgun, Bora; Chen, Zhenyu; Ecklund, Karl Matthew; Geurts, Frank JM; Guilbaud, Maxime; Li, Wei; Michlin, Benjamin; Northup, Michael; Padley, Brian Paul; Redjimi, Radia; Roberts, Jay; Rorie, Jamal; Tu, Zhoudunming; Zabel, James; Betchart, Burton; Bodek, Arie; de Barbaro, Pawel; Demina, Regina; Eshaq, Yossof; Ferbel, Thomas; Galanti, Mario; Garcia-Bellido, Aran; Han, Jiyeon; Harel, Amnon; Hindrichs, Otto; Khukhunaishvili, Aleko; Petrillo, Gianluca; Verzetti, Mauro; Demortier, Luc; Arora, Sanjay; Barker, Anthony; Chou, John Paul; Contreras-Campana, Christian; Contreras-Campana, Emmanuel; Duggan, Daniel; Ferencek, Dinko; Gershtein, Yuri; Gray, Richard; Halkiadakis, Eva; Hidas, Dean; Hughes, Elliot; Kaplan, Steven; Kunnawalkam Elayavalli, Raghav; Lath, Amitabh; Nash, Kevin; Panwalkar, Shruti; Park, Michael; Salur, Sevil; Schnetzer, Steve; Sheffield, David; Somalwar, Sunil; Stone, Robert; Thomas, Scott; Thomassen, Peter; Walker, Matthew; Foerster, Mark; Riley, Grant; Rose, Keith; Spanier, Stefan; York, Andrew; Bouhali, Othmane; Castaneda Hernandez, Alfredo; Dalchenko, Mykhailo; De Mattia, Marco; Delgado, Andrea; Dildick, Sven; Eusebi, Ricardo; Flanagan, Will; Gilmore, Jason; Kamon, Teruki; Krutelyov, Vyacheslav; Mueller, Ryan; Osipenkov, Ilya; Pakhotin, Yuriy; Patel, Rishi; Perloff, Alexx; Rose, Anthony; Safonov, Alexei; Tatarinov, Aysen; Ulmer, Keith; Akchurin, Nural; Cowden, Christopher; Damgov, Jordan; Dragoiu, Cosmin; Dudero, Phillip Russell; Faulkner, James; Kunori, Shuichi; Lamichhane, Kamal; Lee, Sung Won; Libeiro, Terence; Undleeb, Sonaina; Volobouev, Igor; Appelt, Eric; Delannoy, Andrés G; Greene, Senta; Gurrola, Alfredo; Janjam, Ravi; Johns, Willard; Maguire, Charles; Mao, Yaxian; Melo, Andrew; Ni, Hong; Sheldon, Paul; Snook, Benjamin; Tuo, Shengquan; Velkovska, Julia; Xu, Qiao; Arenton, Michael Wayne; Boutle, Sarah; Cox, Bradley; Francis, Brian; Goodell, Joseph; Hirosky, Robert; Ledovskoy, Alexander; Li, Hengne; Lin, Chuanzhe; Neu, Christopher; Wolfe, Evan; Wood, John; Xia, Fan; Clarke, Christopher; Harr, Robert; Karchin, Paul Edmund; Kottachchi Kankanamge Don, Chamath; Lamichhane, Pramod; Sturdy, Jared; Belknap, Donald; Carlsmith, Duncan; Cepeda, Maria; Christian, Allison; Dasu, Sridhara; Dodd, Laura; Duric, Senka; Friis, Evan; Gomber, Bhawna; Hall-Wilton, Richard; Herndon, Matthew; Hervé, Alain; Klabbers, Pamela; Lanaro, Armando; Levine, Aaron; Long, Kenneth; Loveless, Richard; Mohapatra, Ajit; Ojalvo, Isabel; Perry, Thomas; Pierro, Giuseppe Antonio; Polese, Giovanni; Ross, Ian; Ruggles, Tyler; Sarangi, Tapas; Savin, Alexander; Sharma, Archana; Smith, Nicholas; Smith, Wesley H; Taylor, Devin; Woods, Nathaniel
2016-01-01
The CP-violating weak phase $ \\mathrm{ \\phi_s } $ of the $ \\mathrm{ B^0_s } $ meson and the decay width difference $\\Delta \\Gamma_{ \\mathrm{s} }$ of the $ \\mathrm{ B^0_s } $ light and heavy mass eigenstates are measured with the CMS detector at the LHC using a data sample of $ \\mathrm{ B^0_s } \\to \\mathrm{J} / \\psi \\phi(1020) \\to \\mu^+ \\mu^- \\mathrm{ K^{+} K^{-} } $ decays. The analysed data set corresponds to an integrated luminosity of 19.7 fb$^{-1}$ collected in pp collisions at a centre-of-mass energy of 8 TeV. A total of 49 200 reconstructed $ \\mathrm{ B^0_s } $ decays are used to extract the values of $\\mathrm{ \\phi_s }$ and $\\Delta \\Gamma_{ \\mathrm{s} }$ by performing a time-dependent and flavour tagged angular analysis of the $ \\mu^+ \\mu^- \\mathrm{ K^{+} K^{-} } $ final state. The weak phase is measured to be $ \\mathrm{ \\phi_s } = -0.075 \\pm 0.097 \\text{(stat)} \\pm 0.031 \\text{(syst)} $ rad, and the decay width difference is $ \\Delta \\Gamma_{ \\mathrm{s} } = 0.095 \\pm 0.013 \\text{(stat)} \\pm 0.007 \\tex...
Stiffness Analysis and Improvement of Bolt-Plate Contact Assemblies
Pedersen, Niels Leergaard; Pedersen, Pauli
2008-01-01
In a previous study it was shown that, a simplified expression for the stiffness of the plate member in a bolt-plate assembly can be found. The stiffnesses of the bolt and the connected plates are the primary quantities that control the lifetime of a dynamically loaded connection. The present study...... of stiffnesses is extended to include different material parameters by including the influence of Poisson's ratio. Two simple practical formulas are suggested and their accuracies are documented for different bolts and different material (Poisson's ratio). Secondly, the contact analysis between the bolt head...... and the plate is extended by the possibility of designing a gap, that is, a nonuniform distance between the bolt and plate before prestressing. Designing the gap function generates the possibility for a better stress field by which the stiffness of the bolt is lowered, and at the same time the stiffness...
Musculo-tendon length and lengthening velocity of rectus femoris in stiff knee gait.
Jonkers, Ilse; Stewart, Caroline; Desloovere, Kaat; Molenaers, Guy; Spaepen, Arthur
2006-02-01
Inappropriate activity of M. rectus femoris (RF) during swing is believed to contribute to stiff knee gait in cerebral palsy. This study used musculoskeletal modeling techniques to analyze rectus femoris musculo-tendon (MT) length and lengthening velocity during stiff knee gait in 35 children with diplegic cerebral palsy (CP). Duncan Ely test scores were used to categorize the patients into four groups with increasing levels of rectus femoris spasticity. Knee kinematics confirmed a significant reduction and delay of maximal peak knee flexion during swing in the patient groups compared to reference values. Maximal musculo-tendon length of M. rectus femoris was reduced and occurred prematurely in swing. Musculo-tendon lengthening velocity was significantly reduced and the timing of the maximal lengthening velocity was shifted into stance phase. The present study demonstrates altered dynamic behavior of the M. rectus femoris in stiff knee gait and the results indicate that maximal knee flexion in swing was not a valid reference for the MT length of the M. rectus femoris. Furthermore, in the patient group maximal musculo-tendon lengthening velocity of the muscle related to the stance phase rather than the stance-swing transition.
Radotić, Ksenija; Roduit, Charles; Simonović, Jasna; Hornitschek, Patricia; Fankhauser, Christian; Mutavdžić, Dragosav; Steinbach, Gabor; Dietler, Giovanni; Kasas, Sandor
2012-08-08
Cell-wall mechanical properties play a key role in the growth and the protection of plants. However, little is known about genuine wall mechanical properties and their growth-related dynamics at subcellular resolution and in living cells. Here, we used atomic force microscopy (AFM) stiffness tomography to explore stiffness distribution in the cell wall of suspension-cultured Arabidopsis thaliana as a model of primary, growing cell wall. For the first time that we know of, this new imaging technique was performed on living single cells of a higher plant, permitting monitoring of the stiffness distribution in cell-wall layers as a function of the depth and its evolution during the different growth phases. The mechanical measurements were correlated with changes in the composition of the cell wall, which were revealed by Fourier-transform infrared (FTIR) spectroscopy. In the beginning and end of cell growth, the average stiffness of the cell wall was low and the wall was mechanically homogenous, whereas in the exponential growth phase, the average wall stiffness increased, with increasing heterogeneity. In this phase, the difference between the superficial and deep wall stiffness was highest. FTIR spectra revealed a relative increase in the polysaccharide/lignin content.
Warping the Weak Gravity Conjecture
Karta Kooner
2016-08-01
Full Text Available The Weak Gravity Conjecture, if valid, rules out simple models of Natural Inflation by restricting their axion decay constant to be sub-Planckian. We revisit stringy attempts to realise Natural Inflation, with a single open string axionic inflaton from a probe D-brane in a warped throat. We show that warped geometries can allow the requisite super-Planckian axion decay constant to be achieved, within the supergravity approximation and consistently with the Weak Gravity Conjecture. Preliminary estimates of the brane backreaction suggest that the probe approximation may be under control. However, there is a tension between large axion decay constant and high string scale, where the requisite high string scale is difficult to achieve in all attempts to realise large field inflation using perturbative string theory. We comment on the Generalized Weak Gravity Conjecture in the light of our results.
Interpolation for weak Orlicz spaces with condition
JIAO Yong; PENG LiHua; LIU PeiDe
2008-01-01
An interpolation theorem for weak Orlicz spaces generalized by N-functions satisfying M△ condition is given.It is proved to be true for weak Orlicz martingale spaces by weak atomic decomposition of weak Hardy martingale spaces.And applying the interpolation theorem,we obtain some embedding relationships among weak Orlicz martingale spaces.
Teodorescu, Kinneret; Bouchigny, Sylvain; Korman, Maria
2013-08-01
In this study, we explored the time course of haptic stiffness discrimination learning and how it was affected by two experimental factors, the addition of visual information and/or knowledge of results (KR) during training. Stiffness perception may integrate both haptic and visual modalities. However, in many tasks, the visual field is typically occluded, forcing stiffness perception to be dependent exclusively on haptic information. No studies to date addressed the time course of haptic stiffness perceptual learning. Using a virtual environment (VE) haptic interface and a two-alternative forced-choice discrimination task, the haptic stiffness discrimination ability of 48 participants was tested across 2 days. Each day included two haptic test blocks separated by a training block Additional visual information and/or KR were manipulated between participants during training blocks. Practice repetitions alone induced significant improvement in haptic stiffness discrimination. Between days, accuracy was slightly improved, but decision time performance was deteriorated. The addition of visual information and/or KR had only temporary effects on decision time, without affecting the time course of haptic discrimination learning. Learning in haptic stiffness discrimination appears to evolve through at least two distinctive phases: A single training session resulted in both immediate and latent learning. This learning was not affected by the training manipulations inspected. Training skills in VE in spaced sessions can be beneficial for tasks in which haptic perception is critical, such as surgery procedures, when the visual field is occluded. However, training protocols for such tasks should account for low impact of multisensory information and KR.
Wen-ku Shi
2016-01-01
Full Text Available The composite stiffness of parabolic leaf springs with variable stiffness is difficult to calculate using traditional integral equations. Numerical integration or FEA may be used but will require computer-aided software and long calculation times. An efficient method for calculating the composite stiffness of parabolic leaf springs with variable stiffness is developed and evaluated to reduce the complexity of calculation and shorten the calculation time. A simplified model for double-leaf springs with variable stiffness is built, and a composite stiffness calculation method for the model is derived using displacement superposition and material deformation continuity. The proposed method can be applied on triple-leaf and multileaf springs. The accuracy of the calculation method is verified by the rig test and FEA analysis. Finally, several parameters that should be considered during the design process of springs are discussed. The rig test and FEA analytical results indicate that the calculated results are acceptable. The proposed method can provide guidance for the design and production of parabolic leaf springs with variable stiffness. The composite stiffness of the leaf spring can be calculated quickly and accurately when the basic parameters of the leaf spring are known.
Electromagnetism in nonleptonic weak interactions
Ecker, G. E-mail: ecker@doppler.thp.univie.ac.at; Isidori, G.; Mueller, G.; Neufeld, H.; Pich, A
2000-12-18
We construct a low-energy effective field theory that permits the complete treatment of isospin-breaking effects in nonleptonic weak interactions to next-to-leading order. To this end, we enlarge the chiral Lagrangian describing strong and {delta}S=1 weak interactions by including electromagnetic terms with the photon as additional dynamical degree of freedom. The complete and minimal list of local terms at next-to-leading order is given. We perform the one-loop renormalization at the level of the generating functional and specialize to K{yields}{pi}{pi} decays.
Cosmology and the weak interaction
Schramm, D.N. (Fermi National Accelerator Lab., Batavia, IL (USA)):(Chicago Univ., IL (USA))
1989-12-01
The weak interaction plays a critical role in modern Big Bang cosmology. This review will emphasize two of its most publicized cosmological connections: Big Bang nucleosynthesis and Dark Matter. The first of these is connected to the cosmological prediction of Neutrino Flavours, N{sub {nu}} {approximately} 3 which is now being confirmed at SLC and LEP. The second is interrelated to the whole problem of galaxy and structure formation in the universe. This review will demonstrate the role of the weak interaction both for dark matter candidates and for the problem of generating seeds to form structure. 87 refs., 3 figs., 5 tabs.
Weak disorder in Fibonacci sequences
Ben-Naim, E [Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Krapivsky, P L [Department of Physics and Center for Molecular Cybernetics, Boston University, Boston, MA 02215 (United States)
2006-05-19
We study how weak disorder affects the growth of the Fibonacci series. We introduce a family of stochastic sequences that grow by the normal Fibonacci recursion with probability 1 - {epsilon}, but follow a different recursion rule with a small probability {epsilon}. We focus on the weak disorder limit and obtain the Lyapunov exponent that characterizes the typical growth of the sequence elements, using perturbation theory. The limiting distribution for the ratio of consecutive sequence elements is obtained as well. A number of variations to the basic Fibonacci recursion including shift, doubling and copying are considered. (letter to the editor)
Sato, Eugene J; Killian, Megan L; Choi, Anthony J; Lin, Evie; Esparza, Mary C; Galatz, Leesa M; Thomopoulos, Stavros; Ward, Samuel R
2014-09-01
Rotator cuff tears can cause irreversible changes (e.g., fibrosis) to the structure and function of the injured muscle(s). Fibrosis leads to increased muscle stiffness resulting in increased tension at the rotator cuff repair site. This tension influences repairability and healing potential in the clinical setting. However, the micro- and meso-scale structural and molecular sources of these whole-muscle mechanical changes are poorly understood. Here, single muscle fiber and fiber bundle passive mechanical testing was performed on rat supraspinatus and infraspinatus muscles with experimentally induced massive rotator cuff tears (Tenotomy) as well as massive tears with chemical denervation (Tenotomy + BTX) at 8 and 16 weeks post-injury. Titin molecular weight, collagen content, and myosin heavy chain profiles were measured and correlated with mechanical variables. Single fiber stiffness was not different between controls and experimental groups. However, fiber bundle stiffness was significantly increased at 8 weeks in the Tenotomy + BTX group compared to Tenotomy or control groups. Many of the changes were resolved by 16 weeks. Only fiber bundle passive mechanics was weakly correlated with collagen content. These data suggest that tendon injury with concomitant neuromuscular compromise results in extra-cellular matrix production and increases in stiffness of the muscle, potentially complicating subsequent attempts for surgical repair. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
Influence of environmental noise on the weak value amplification
Zhu, Xuannmin; Zhang, Yu-Xiang
2016-08-01
Quantum systems are always disturbed by environmental noise. We have investigated the influence of the environmental noise on the amplification in weak measurements. Three typical quantum noise processes are discussed in this article. The maximum expectation values of the observables of the measuring device decrease sharply with the strength of the depolarizing and phase damping channels, while the amplification effect of weak measurement is immune to the amplitude damping noise. To obtain significantly amplified signals, we must ensure that the preselection quantum systems are kept away from the depolarizing and phase damping processes.
The gearing function of running shoe longitudinal bending stiffness.
Willwacher, Steffen; König, Manuel; Braunstein, Björn; Goldmann, Jan-Peter; Brüggemann, Gert-Peter
2014-07-01
The purpose of the present study was to investigate whether altered longitudinal bending stiffness (LBS) levels of the midsole of a running shoe lead to a systematic change in lower extremity joint lever arms of the ground reaction force (GRF). Joint moments and GRF lever arms in the sagittal plane were determined from 19 male subjects running at 3.5 m/s using inverse dynamics procedures. LBS was manipulated using carbon fiber insoles of 1.9 mm and 3.2 mm thickness. Increasing LBS led to a significant shift of joint lever arms to a more anterior position. Effects were more pronounced at distal joints. Ankle joint moments were not significantly increased in the presence of higher GRF lever arms when averaged over all subjects. Still, two individual strategies (1: increase ankle joint moments while keeping push-off times almost constant, 2: decrease ankle joint moments and increase push-off times) could be identified in response to increased ankle joint lever arms that might reflect individual differences between subjects with respect to strength capacities or anthropometric characteristics. The results of the present study indicate that LBS systematically influences GRF lever arms of lower extremity joints during the push-off phase in running. Further, individual responses to altered LBS levels could be identified that could aid in finding optimum LBS values for a given individual. Copyright © 2014 Elsevier B.V. All rights reserved.
The cohomology group of weak entwining structure
2007-01-01
In this paper, we reveal that a weak entwining structure admits a rich cohomology theory. As an application we compute the cohomology of a weak entwining structure associated to a weak coalgebra-Galois extension.
Noninvasive pulse wave analysis for the determination of central artery stiffness
Wittrock, Marc; Scholze, Alexandra; Compton, Friederike;
2009-01-01
Central artery stiffness predicts cardiovascular structural damage and clinical outcome. It is controversial whether central artery stiffness can be determined by noninvasive measurements. We compared noninvasive determination of central artery stiffness obtained from applanation tonometry of the...
Second threshold in weak interactions
Veltman, M.J.G.
1977-01-01
The point of view that weak interactions must have a second threshold below 300 – 600 GeV is developed. Above this threshold new physics must come in. This new physics may be the Higgs system, or some other nonperturbative system possibly having some similarities to the Higgs system. The limit of la
Beam splitting on weak illumination.
Snyder, A W; Buryak, A V; Mitchell, D J
1998-01-01
We demonstrate, in both two and three dimensions, how a self-guided beam in a non-Kerr medium is split into two beams on weak illumination. We also provide an elegant physical explanation that predicts the universal character of the observed phenomenon. Possible applications of our findings to guiding light with light are also discussed.
Weak measurements and supraluminal communication
Belinsky, A V
2016-01-01
There is suggested a version of the experiment with a correlated pair of particles in the entangled state. The experiment demonstrates that, in the case of weak and/or non-demolition measurements of one of the particles, it is possible to transmit information with a speed not limited by velocity of light.
Thomys, Janus; Zhang, Xiaohong
2013-01-01
We describe weak-BCC-algebras (also called BZ-algebras) in which the condition (x∗y)∗z = (x∗z)∗y is satisfied only in the case when elements x, y belong to the same branch. We also characterize ideals, nilradicals, and nilpotent elements of such algebras. PMID:24311983
Eldercare at Home: Bone Weakness
... socialize. This can make exercising fun. If you don't exercise, your bones and muscles will become weak and your chances of falling will increase. Let’s exercise together. I will pick you up and we will go to the mall and walk for a little ...
Submanifolds Weakly Associated with Graphs
A Carriazo; L M Fernández; A Rodríguez-Hidalgo
2009-06-01
We establish an interesting link between differential geometry and graph theory by defining submanifolds weakly associated with graphs. We prove that, in a local sense, every submanifold satisfies such an association, and other general results. Finally, we study submanifolds associated with graphs either in low dimensions or belonging to some special families.
Controlled Unusual Stiffness of Mechanical Metamaterials.
Lee, Wooju; Kang, Da-Young; Song, Jihwan; Moon, Jun Hyuk; Kim, Dongchoul
2016-02-03
Mechanical metamaterials that are engineered with sub-unit structures present unusual mechanical properties depending on the loading direction. Although they show promise, their practical utility has so far been somewhat limited because, to the best of our knowledge, no study about the potential of mechanical metamaterials made from sophisticatedly tailored sub-unit structures has been made. Here, we present a mechanical metamaterial whose mechanical properties can be systematically designed without changing its chemical composition or weight. We study the mechanical properties of triply periodic bicontinuous structures whose detailed sub-unit structure can be precisely fabricated using various sub-micron fabrication methods. Simulation results show that the effective wave velocity of the structures along with different directions can be designed to introduce the anisotropy of stiffness by changing a volume fraction and aspect ratio. The ratio of Young's modulus to shear modulus can be increased by up to at least 100, which is a 3500% increase over that of isotropic material (2.8, acrylonitrile butadiene styrene). Furthermore, Poisson's ratio of the constituent material changes the ratio while Young's modulus does not influence it. This study presents the promising potential of mechanical metamaterials for versatile industrial and biomedical applications.
STIFFNESS MODIFICATION OF COTTON IN CHITOSAN TREATMENT
CAMPOS Juan
2017-05-01
Full Text Available Chitosan is a biopolymer obtained from chitin, and among their most important aspects highlights its applications in a lot of industrial sectors due to its intrinsic properties, especially in the textile sector. In the last years, chitosan is widely used in the cotton and wool finishing processes due to its bond between them and its properties as an antifungical and antimicrobial properties. In this paper three different molecular weight chitosan are used in the finishing process of cotton to evaluate its influence in the surface properties modification. In order to evaluate the effect of the treatment with chitosan, flexural stiffness test is performed in warp and weft direction, and then the total value is calculated. The cotton fabric is treated with 5 g/L of different types of chitosan in an impregnation bath. This study shows the extent of surface properties modification of the cotton provided by three types of chitosan treatment. The results show that all types of chitosan modify the cotton flexural rigidity properties but the one which modifies it in a relevant manner is chitosan originated from shrimps. Chitosan, textile, flexural stiffnes, chitin, cotton.
Variable Volumetric Stiffness Fluid Mount Design
Nader Vahdati
2004-01-01
Full Text Available Passive fluid mounts are commonly used in the automotive and aerospace applications to isolate the cabin from the engine noise and vibration. Due to manufacturing and material variabilities, no two identical fluid mount designs act the same. So, fluid mounts are tuned one by one before it is shipped out to customers. In some cases, for a batch of fluid mounts manufactured at the same time, one is tuned and the rest is set to the same settings. In some cases they are shipped as is with its notch frequency not being in its most optimum location. Since none of the passive fluid mount parameters are controllable, the only way to tune the mount is to redesign the mount by changing fluid, changing inertia track length or diameter, or changing rubber stiffness. This trial and error manufacturing process is very costly. To reduce the fluid mount notch frequency tuning cycle time, a new fluid mount design is proposed. In this new fluid mount design, the notch frequency can be easily modified without the need for any redesigns. In this paper, the new design concept, and its mathematical model and simulation results will be presented.
Investigation of the torsional stiffness of flexible disc coupling
Buryy, A.; Simonovsky, V.; Obolonik, V.
2017-08-01
Calculation of flexible coupling torsional stiffness is required when analyzing the torsional vibrations of the reciprocating machinery train. While having the lowest torsional stiffness of all the elements of the train, flexible coupling has a significant influence on the natural frequencies of torsional vibration. However, considering structural complexity of coupling, precise definition of its torsional stiffness is quite a difficult task. The paper presents a method for calculating the torsional stiffness of flexible disc coupling based on the study of its finite element model response under the action of torque. The analysis of the basic parameters that quantitatively and qualitatively affect the coupling torsional stiffness has been also provided. The results of the calculation as well as model adequacy, sufficient for practical application, have been confirmed at the experimental measurement of flexible disc coupling torsional stiffness. The obtained elastic characteristics (dependences of applied torque and torsional stiffness versus twist angle) are nonlinear in the initial stage of loading. This feature should be taken into account when creating reliable mathematical models of torsional vibrations of reciprocating machinery trains containing flexible disc couplings.
Stiffness identification of four-point-elastic-support rigid plate
彭利平; 刘初升; 武继达; 王帅
2015-01-01
As the stiffness of the elastic support varies with the physical-chemical erosion and mechanical friction, model catastrophe of a single degree-of-freedom (DOF) isolation system may occur. A 3-DOF four-point-elastic-support rigid plate (FERP) structure is presented to describe the catastrophic isolation system. Based on the newly-established structure, theoretical derivation for stiffness matrix calculation by free response (SMCbyFR) and the method of stiffness identification by stiffness matrix disassembly (SIbySMD) are proposed. By integrating the SMCbyFR and the SIbySMD and defining the stiffness assurance criterion (SAC), the procedures for stiffness identification of a FERP structure (SIFERP) are summarized. Then, a numerical example is adopted for the SIFERP validation, in which the simulated tested free response data are generated by the numerical methods, and operation for filtering noise is conducted to imitate the practical application. Results in the numerical example demonstrate the feasibility and accuracy of the developed SIFERP for stiffness identification.
Stiffness and Angular Deflection analysis of Revolute Manipulator
Pundru Srinivasa Rao
2014-03-01
Full Text Available This paper proposed to determine the Cartesian stiffness matrix and angular deflection analysis of revolute manipulator. The selected manipulator has rigid fixed link, two movable links and two rotary joints with joint stiffness coefficients are taken into account. The kinematic model of revolute joint manipulator has considered as a planar kinematic chain, which is composed by rigid fixed link and two revolute joints with clearance and deformable elements. The calculation of stiffness matrix depends on Jacobian matrix and change of configuration. The rotational joints are modeled as torsion springs with the same stiffness constant. The relative angular deflections are proportional to the actuated torques taken into account. The subject of this paper has to describe a method for stiffness analysis of serial manipulator. In the present work is to derive the stiffness matrix and angular deflection equations in the Robotic manipulator under the consideration of two-link optimum geometry model for rotary joint manipulator. The stiffness values are measured by displacements of its revolute links loaded by force.
Substrate stiffness regulates extracellular matrix deposition by alveolar epithelial cells
Eisenberg, Jessica L; Safi, Asmahan; Wei, Xiaoding; Espinosa, Horacio D; Budinger, GR Scott; Takawira, Desire; Hopkinson, Susan B; Jones, Jonathan CR
2012-01-01
Aim The aim of the study was to address whether a stiff substrate, a model for pulmonary fibrosis, is responsible for inducing changes in the phenotype of alveolar epithelial cells (AEC) in the lung, including their deposition and organization of extracellular matrix (ECM) proteins. Methods Freshly isolated lung AEC from male Sprague Dawley rats were seeded onto polyacrylamide gel substrates of varying stiffness and analyzed for expression and organization of adhesion, cytoskeletal, differentiation, and ECM components by Western immunoblotting and confocal immunofluorescence microscopy. Results We observed that substrate stiffness influences cell morphology and the organization of focal adhesions and the actin cytoskeleton. Surprisingly, however, we found that substrate stiffness has no influence on the differentiation of type II into type I AEC, nor does increased substrate stiffness lead to an epithelial–mesenchymal transition. In contrast, our data indicate that substrate stiffness regulates the expression of the α3 laminin subunit by AEC and the organization of both fibronectin and laminin in their ECM. Conclusions An increase in substrate stiffness leads to enhanced laminin and fibronectin assembly into fibrils, which likely contributes to the disease phenotype in the fibrotic lung. PMID:23204878
Simvastatin Ameliorates Matrix Stiffness-Mediated Endothelial Monolayer Disruption.
Lampi, Marsha C; Faber, Courtney J; Huynh, John; Bordeleau, Francois; Zanotelli, Matthew R; Reinhart-King, Cynthia A
2016-01-01
Arterial stiffening accompanies both aging and atherosclerosis, and age-related stiffening of the arterial intima increases RhoA activity and cell contractility contributing to increased endothelium permeability. Notably, statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors whose pleiotropic effects include disrupting small GTPase activity; therefore, we hypothesized the statin simvastatin could be used to attenuate RhoA activity and inhibit the deleterious effects of increased age-related matrix stiffness on endothelial barrier function. Using polyacrylamide gels with stiffnesses of 2.5, 5, and 10 kPa to mimic the physiological stiffness of young and aged arteries, endothelial cells were grown to confluence and treated with simvastatin. Our data indicate that RhoA and phosphorylated myosin light chain activity increase with matrix stiffness but are attenuated when treated with the statin. Increases in cell contractility, cell-cell junction size, and indirect measurements of intercellular tension that increase with matrix stiffness, and are correlated with matrix stiffness-dependent increases in monolayer permeability, also decrease with statin treatment. Furthermore, we report that simvastatin increases activated Rac1 levels that contribute to endothelial barrier enhancing cytoskeletal reorganization. Simvastatin, which is prescribed clinically due to its ability to lower cholesterol, alters the endothelial cell response to increased matrix stiffness to restore endothelial monolayer barrier function, and therefore, presents a possible therapeutic intervention to prevent atherogenesis initiated by age-related arterial stiffening.
Martial arts training attenuates arterial stiffness in middle aged adults.
Douris, Peter C; Ingenito, Teresa; Piccirillo, Barbara; Herbst, Meredith; Petrizzo, John; Cherian, Vincen; McCutchan, Christopher; Burke, Caitlin; Stamatinos, George; Jung, Min-Kyung
2013-09-01
Arterial stiffness increases with age and is related to an increased risk of coronary artery disease. Poor trunk flexibility has been shown to be associated with arterial stiffness in middle-aged subjects. The purpose of our research study was to measure arterial stiffness and flexibility in healthy middle-aged martial artists compared to age and gender matched healthy sedentary controls. Ten martial artists (54.0 ± 2.0 years), who practice Soo Bahk Do (SBD), a Korean martial art, and ten sedentary subjects (54.7 ± 1.8 years) for a total of twenty subjects took part in this cross-sectional study. Arterial stiffness was assessed in all subjects using pulse wave velocity (PWV), a recognized index of arterial stiffness. Flexibility of the trunk and hamstring were also measured. The independent variables were the martial artists and matched sedentary controls. The dependent variables were PWV and flexibility. There were significant differences, between the SBD practitioners and sedentary controls, in PWV (P = 0.004), in trunk flexibility (P= 0.002), and in hamstring length (P= 0.003). The middle-aged martial artists were more flexible in their trunk and hamstrings and had less arterial stiffness compared to the healthy sedentary controls. The flexibility component of martial art training or flexibility exercises in general may be considered as a possible intervention to reduce the effects of aging on arterial stiffness.
Simvastatin Ameliorates Matrix Stiffness-Mediated Endothelial Monolayer Disruption.
Marsha C Lampi
Full Text Available Arterial stiffening accompanies both aging and atherosclerosis, and age-related stiffening of the arterial intima increases RhoA activity and cell contractility contributing to increased endothelium permeability. Notably, statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA reductase inhibitors whose pleiotropic effects include disrupting small GTPase activity; therefore, we hypothesized the statin simvastatin could be used to attenuate RhoA activity and inhibit the deleterious effects of increased age-related matrix stiffness on endothelial barrier function. Using polyacrylamide gels with stiffnesses of 2.5, 5, and 10 kPa to mimic the physiological stiffness of young and aged arteries, endothelial cells were grown to confluence and treated with simvastatin. Our data indicate that RhoA and phosphorylated myosin light chain activity increase with matrix stiffness but are attenuated when treated with the statin. Increases in cell contractility, cell-cell junction size, and indirect measurements of intercellular tension that increase with matrix stiffness, and are correlated with matrix stiffness-dependent increases in monolayer permeability, also decrease with statin treatment. Furthermore, we report that simvastatin increases activated Rac1 levels that contribute to endothelial barrier enhancing cytoskeletal reorganization. Simvastatin, which is prescribed clinically due to its ability to lower cholesterol, alters the endothelial cell response to increased matrix stiffness to restore endothelial monolayer barrier function, and therefore, presents a possible therapeutic intervention to prevent atherogenesis initiated by age-related arterial stiffening.
Fabrication of Janus hydrogels with stiffness gradient using drop coalescence
Lee, Donghee; Golden, Kale; Ryu, Sangjin
2016-11-01
The stiffness of the extracellular matrix (ECM) regulates cellular behaviors, and polyacrylamide (PAAM) gels with stiffness gradient have been used to simulate inhomogeneous ECM and to study the effects of the ECM stiffness on cells. Such hydrogel substrates with stiffness gradient can be fabricated with relatively complicated methods using microfluidics and moving masks. In our study, we develop a simpler method for fabricating Janus hydrogel which has a gradient of stiffness. Two prepolymer solutions were prepared for soft and stiff gel compositions, respectively, and one drop of each solution was placed on a hydrophobic patterned glass. Then, these two drops were gently squeezed by another glass being slowly lowered until coalescence, and gel polymerization was initiated after a certain time period for mixing. The motion of the drops was guided by the hydrophobic pattern. AFM nano-indentation showed that the fabricated Janus PAAM gels have a stiffness gradient which could be controlled by increasing mixing time. This study was supported by Bioengineering for Human Health Grant from UNL and UNMC.
On the weak project construction cost management
高守刚; 姜婧; 李玲
2013-01-01
the weak cost management is the most talked about topics in the weak industry, but also the basis of the weak construction business management and focus. With the increasingly fierce market competition, weak construction enterprises, the competition among enterprises wil gradual y transition from product quality competition to price competition. To strengthen the management of the weak construction enterprises cost, cut public spending ef iciency, improve market competitiveness, wil be the main way most weak construction corporate earnings and long-term business strategy. Based on the to weak project construction cost management based on analysis of the type of project construction costs, and further proposed the weak project construction cost management measures.
Large Artery Stiffness Assessment Using SphygmoCor Technology
Butlin, Mark; Qasem, Ahmad
2017-01-01
Large artery stiffness assessment has been an integral part of the SphygmoCor technology since 1998. Aortic stiffness is approximated with non-invasive measurement of carotid-femoral pulse wave velocity, with improvements made with time to make the assessment procedure quicker and more user independent. Also standard in the devices is the ability to reliably calculate the central aortic waveform shape from a peripheral pressure waveform from either the brachial or radial artery. This waveform contains much information beyond peak and trough (systolic and diastolic pressure). Relative waveform features such as the augmentation index, wave reflection magnitude, reflection time index, and subendocardial viability ratio are parameters that are influenced by the stiffness of systemic arteries. This article briefly describes these parameters related to large artery stiffness and provides reference to validation and repeatability studies relative to the clinical use of the SphygmoCor devices. It is beyond the scope to review here the 424 original research articles that have employed SphygmoCor devices in measuring arterial stiffness. Instead, the method of measurement across the devices is described, including tonometry, volumetric displacement through cuff placement around limbs, and ambulatory monitoring. Key population and subpopulation studies are cited where the average stiffness parameter progression with age and gender, as measured by SphygmoCor devices, is quantified in the healthy and general population. Finally, with reference to guidelines from working groups on arterial stiffness and hypertension, the clinical utility of large artery stiffness measurement is discussed in the context of the arterial stiffness parameters provided by the SphygmoCor systems. PMID:28229053
A modified beam stiffness matrix for superconductor elements
Gori, R.; Schrefler, B.A. (Padua Univ. (Italy). Ist. di Scienza e Tecnica delle Costruzioni)
1989-10-01
The components of the stiffness matrix of superconductor elements are derived taking into account the effects of the wrapping of superconductor strands around the internal insulating strip and of possible stabilizing profiles around conductor core. It is already known that the inclination of the strands referred to the longitudinal axis of the superconductor produces a reduction of the axial stiffness and a considerable increase in torsional stiffness. Here also the effects of bending are taken into account, completing hence the previous investigation. Examples relating to superconductors proposed for the Toroidal Field Coil of the Next European Torus are shown. In that instance the strand transposition is carried out by roebling. (orig.).
PARALLEL COMPOUND METHODS FOR SOLVING PARTITIONED STIFF SYSTEMS
Li-rong Chen; De-gui Liu
2001-01-01
This paper deals with the solution of partitioned systems of nonlinear stiff differential equations. Given a differential system, the user may specify some equations to be stiff and others to be nonstiff. For the numerical solution of such a system Parallel Compound Methods(PCMs) are studied. Nonstiff equations are integrated by a parallel explicit RK method while a parallel Rosenbrock method is used for the stiff part of the system. Their order conditions, their convergence and their numerical stability are discussed,and the numerical tests are conducted on a personal computer and a parallel computer.
The Dynamic Stiffness of Surface Footings for Offshore Wind Turbines
Vahdatirad, Mohammadjavad; Andersen, Lars; Clausen, Johan;
2011-01-01
This study concerns the dynamic stiffness of foundations for large offshore wind turbines. Especially, the purpose of the analysis is to quantify the uncertainties related to the first natural frequency of a turbine supported by a surface footing on layered soil. The dynamic properties...... due to sediment transportation. Further, the stiffness and density of the materials within a single layer is subject to uncertainties. This leads to uncertainties of the dynamic stiffness of the foundation and therefore the natural frequencies. The aim of the study is to quantify the level...... of uncertainties and discuss the utilization of reliability-based design of surface footings for wind turbines....
Hormones and arterial stiffness in patients with chronic kidney disease.
Gungor, Ozkan; Kircelli, Fatih; Voroneanu, Luminita; Covic, Adrian; Ok, Ercan
2013-01-01
Cardiovascular disease constitutes the major cause of mortality in patients with chronic kidney disease. Arterial stiffness is an important contributor to the occurrence and progression of cardiovascular disease. Various risk factors, including altered hormone levels, have been suggested to be associated with arterial stiffness. Based on the background that chronic kidney disease predisposes individuals to a wide range of hormonal changes, we herein review the available data on the association between arterial stiffness and hormones in patients with chronic kidney disease and summarize the data for the general population.
A novel energy-efficient rotational variable stiffness actuator.
Rao, Shodhan; Carloni, Raffaella; Stramigioli, Stefano
2011-01-01
This paper presents the working principle, the design and realization of a novel rotational variable stiffness actuator, whose stiffness can be varied independently of its output angular position. This actuator is energy-efficient, meaning that the stiffness of the actuator can be varied by keeping constant the internal stored energy of the actuator. The principle of the actuator is an extension of the principle of translational energy-efficient actuator vsaUT. A prototype based on the principle has been designed, in which ball-bearings and linear slide guides have been used in order to reduce losses due to friction.
Space group constraints on weak indices in topological insulators
Varjas, Dániel; de Juan, Fernando; Lu, Yuan-Ming
2017-07-01
Lattice translation symmetry gives rise to a large class of "weak" topological insulators (TIs), characterized by translation-protected gapless surface states and dislocation bound states. In this work we show that space group symmetries lead to constraints on the weak topological indices that define these phases. In particular, we show that screw rotation symmetry enforces the Hall conductivity in planes perpendicular to the screw axis to be quantized in multiples of the screw rank, which generally applies to interacting systems. We further show that certain 3D weak indices associated with quantum spin Hall effects (class AII) are forbidden by the Bravais lattice and by glide or even-fold screw symmetries. These results put strong constraints on weak TI candidates in the experimental and numerical search for topological materials, based on the crystal structure alone.
Arterial pressure suffices to increase liver stiffness.
Piecha, Felix; Peccerella, Teresa; Bruckner, Tom; Seitz, Helmut-Karl; Rausch, Vanessa; Mueller, Sebastian
2016-11-01
Noninvasive measurement of liver stiffness (LS) has been established to screen for liver fibrosis. Since LS is also elevated in response to pressure-related conditions such as liver congestion, this study was undertaken to learn more about the role of arterial pressure on LS. LS was measured by transient elastography (μFibroscan platform, Echosens, Paris, France) during single intravenous injections of catecholamines in anesthetized rats with and without thioacetamide (TAA)-induced fibrosis. The effect of vasodilating glycerol trinitrate (GTN) on LS was also studied. Pressures in the abdominal aorta and caval and portal veins were measured in real time with the PowerLab device (AD Instruments, Dunedin, New Zealand). Baseline LS values in all rats (3.8 ± 0.5 kPa, n = 25) did not significantly differ from those in humans. Epinephrine and norepinephrine drastically increased mean arterial pressure (MAP) from 82 to 173 and 156 mmHg. Concomitantly, LS almost doubled from 4 to 8 kPa, while central venous pressure remained unchanged. Likewise, portal pressure only showed a slight and delayed increase. In the TAA-induced fibrosis model, LS increased from 9.5 ± 1.0 to 25.6 ± 14.7 kPa upon epinephrine injection and could efficiently be decreased by GTN. We finally show a direct association in humans in a physiological setting of elevated cardiac output and MAP. During continuous spinning at 200 W, MAP increased from 84 ± 8 to 99 ± 11 mmHg while LS significantly increased from 4.4 ± 1.8 to 6.7 ± 2.1 kPa. In conclusion, our data show that arterial pressure suffices to increase LS. Moreover, lowering MAP efficiently decreases LS in fibrotic livers that are predominantly supplied by arterial blood. Copyright © 2016 the American Physiological Society.
Palmer, Ty B; Jenkins, Nathaniel D M; Thompson, Brennan J; Smith, Douglas B; Cramer, Joel T
2014-01-01
We examined the relationship between passive stiffness of posterior hip and thigh muscles and muscle power output before and after normalization of passive stiffness to muscle cross-sectional area (CSA). Pearson correlation coefficients (r) were used to assess the relationships between the normalized and non-normalized slopes of the initial (phase 1) and final (phase 2) portions of the angle-torque curve and peak power output (Pmax). A significant positive relationship was observed between the non-normalized slope of phase 1 and Pmax (r = 0.723; P ≤ 0.001); however, no correlations were observed between the normalized slope of phase 1 and Pmax (r = 0.244; P = 0.299) nor between Pmax and the normalized and non-normalized slopes of phase 2 (r = -0.159-0.418; P = 0.067-0.504). The findings suggest that muscle size, rather than stiffness, accounted for a significant portion of the variance in muscle power output. Copyright © 2013 Wiley Periodicals, Inc.
Hall, Lawrence J; Ruderman, Joshua T
2014-01-01
The measured values of the weak scale, $v$, and the first generation masses, $m_{u,d,e}$, are simultaneously explained in the multiverse, with all these parameters scanning independently. At the same time, several remarkable coincidences are understood. Small variations in these parameters away from their measured values lead to the instability of hydrogen, the instability of heavy nuclei, and either a hydrogen or a helium dominated universe from Big Bang Nucleosynthesis. In the 4d parameter space of $(m_u,m_d,m_e,v)$, catastrophic boundaries are reached by separately increasing each parameter above its measured value by a factor of $(1.4,1.3,2.5,\\sim5)$, respectively. The fine-tuning problem of the weak scale in the Standard Model is solved: as $v$ is increased beyond the observed value, it is impossible to maintain a significant cosmological hydrogen abundance for any values of $m_{u,d,e}$ that yield both hydrogen and heavy nuclei stability. For very large values of $v$ a new regime is entered where weak in...
"INTRAOPERATIVE SPINAL STIFFNESS MEASUREMENT IN MANAGEMENT OF SPINAL CANAL STENOSIS "
M. Karami
2005-08-01
Full Text Available In this study to determine whether spine stiffness is predictive of clinical results after lumbar spinal fusion for spinal stenosis, a total of 78 patients were measured intraoperatively with Kocher clamp manual distraction technique to determine motion segment stiffness then spinal fusion was performed for any loose segment. Statistical analysis revealed that stiffness measurement correlate with clinical results of surgery. During a minimum of 2 years follow up after surgery, patients who had loose motion segment before or after decompression and were fused had the same level of satisfaction with surgical results as patients without loose segments and fusion. We concluded that intraoperative spinal stiffness measurement provide a good indicator to spine fusion after lumbar canal stenosis surgery.
Polyester mooring stiffness modeling for deepwater floating system
Chen Yongjun; Qu Yan; Zhang Tianyu
2013-01-01
Polyester mooring has become increasing popular to serve as permanent station-keeping system for deepwater floating system during recent years.Comparing to the traditional steel wire mooring,polyester mooring provides significant benefits in deepwater,such as reduced installed capital expenditure (CAPEX) and smaller vertical loads on host platform.Polyester rope is a visco-elastic material,and its stiffness is nonlinear and affected by mean load,load range,loading period and loading history.There is a perception that the polyester stiffness model has significant impact on the floating system' s performance.This paper presents a detailed description and comparison of two stiffness models and three analytic approaches,and provides a systematic study of the impact of polyester mooring stiffness modeling on the deepwater floating system performance.
Introduction to the Points Singly Used for Stiff Neck
李鸿超; 余光辉
2004-01-01
@@ In acupuncture treatment of stiff neck, based on the patients' individual conditions, flexible application of different single points can quickly bring about good therapeutic results. The following is a collection of the points singly used for stiffneck.
Torque-stiffness-controlled dynamic walking with central pattern generators.
Huang, Yan; Vanderborght, Bram; Van Ham, Ronald; Wang, Qining
2014-12-01
Walking behavior is modulated by controlling joint torques in most existing passivity-based bipeds. Controlled Passive Walking with adaptable stiffness exhibits controllable natural motions and energy efficient gaits. In this paper, we propose torque-stiffness-controlled dynamic bipedal walking, which extends the concept of Controlled Passive Walking by introducing structured control parameters and a bio-inspired control method with central pattern generators. The proposed walking paradigm is beneficial in clarifying the respective effects of the external actuation and the internal natural dynamics. We present a seven-link biped model to validate the presented walking. Effects of joint torque and joint stiffness on gait selection, walking performance and walking pattern transitions are studied in simulations. The work in this paper develops a new solution of motion control of bipedal robots with adaptable stiffness and provides insights of efficient and sophisticated walking gaits of humans.
Identification of dynamic stiffness matrix of bearing joint region
Feng HU; Bo WU; Youmin HU; Tielin SHI
2009-01-01
The paper proposes an identification method of the dynamic stiffness matrix of a bearing joint region on the basis of theoretical analysis and experiments. The author deduces an identification model of the dynamic stiffness matrix from the synthetic substructure method. The dynamic stiffness matrix of the bearing joint region can be identified by measuring the matrix of frequency response function (FRFs) of the substructure (axle) and whole structure (assembly of the axle, bearing, and bearing housing) in different positions. Considering difficulty in measuring angular displacement, applying moment, and directly measuring relevant FRFs of rotational degree of freedom, the author employs an accurately calibrated finite element model of the unconstrained structure for indirect estimation. With experiments and simulation analysis, FRFs related with translational degree of freedom, which is estimated through the finite element model, agrees with experimental results, and there is very high reliability in the identified dynamic stiffness matrix of the bearing joint region.
Gallstone disease is associated with arterial stiffness progression.
Yu, Kai-Jing; Zhang, Ji-Rong; Li, Ying; Huang, Xiaoyi; Liu, Tiemin; Li, Chuanfu; Wang, Rui-Tao
2017-01-01
Gallstones have been linked to dyslipidemia, metabolic syndrome and cardiovascular disease. Arterial stiffness is an indicator of subclinical atherosclerosis. The aim of this study was to prospectively examine the relationship between gallstone disease and arterial stiffness progression in 347 men and 454 women. These subjects were followed for 7 years. Arterial stiffness progression was measured based on increases in brachial-ankle pulse wave velocity. Changes in brachial-ankle pulse wave velocity during the study period were significantly greater in patients with gallstones than in subjects without gallstones. After adjusting for multiple risk factors, gallstone disease was found to be a significant and independent predictor of brachial-ankle pulse wave velocity progression (β=0.189; Pgallstone disease is an independent predictor of arterial stiffness progression, even after adjusting for other cardiovascular risk factors.
Accuracy Improvement for Stiffness Modeling of Parallel Manipulators
Pashkevich, Anatoly; Chablat, Damien; Wenger, Philippe
2009-01-01
The paper focuses on the accuracy improvement of stiffness models for parallel manipulators, which are employed in high-speed precision machining. It is based on the integrated methodology that combines analytical and numerical techniques and deals with multidimensional lumped-parameter models of the links. The latter replace the link flexibility by localized 6-dof virtual springs describing both translational/rotational compliance and the coupling between them. There is presented detailed accuracy analysis of the stiffness identification procedures employed in the commercial CAD systems (including statistical analysis of round-off errors, evaluating the confidence intervals for stiffness matrices). The efficiency of the developed technique is confirmed by application examples, which deal with stiffness analysis of translational parallel manipulators.
Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis
Saneyasu, Takaoki; Akhtar, Riaz
2016-01-01
Tissue and matrix stiffness affect cell properties during morphogenesis, cell growth, differentiation, and migration and are altered in the tissue remodeling following injury and the pathological progression. However, detailed molecular mechanisms underlying alterations of stiffness in vivo are still poorly understood. Recent engineering technologies have developed powerful techniques to characterize the mechanical properties of cell and matrix at nanoscale levels. Extracellular matrix (ECM) influences mechanical tension and activation of pathogenic signaling during the development of chronic fibrotic diseases. In this short review, we will focus on the present knowledge of the mechanisms of how ECM stiffness is regulated during the development of liver fibrosis and the molecules involved in ECM stiffness as a potential therapeutic target for liver fibrosis. PMID:27800489
Wing/store flutter with nonlinear pylon stiffness
Desmarais, R. N.; Reed, W. H., III
1980-01-01
Recent wind tunnel tests and analytical studies show that a store mounted on a pylon with soft pitch stiffness provides substantial increase in flutter speed of fighter aircraft and reduces dependency of flutter on mass and inertia of the store. This concept, termed the decoupler pylon, utilizes a low frequency control system to maintain pitch alignment of the store during maneuvers and changing flight conditions. Under rapidly changing transient loads, however, the alignment control system may allow the store to momentarily bottom against a relatively stiff backup structure in which case the pylon stiffness acts as a hardening nonlinear spring. Such structural nonlinearities are known to affect not only the flutter speed but also the basic behavior of the instability. The influence of pylon stiffness nonlinearities or the flutter characteristics of wing mounted external stores is examined.
Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis
Takaoki Saneyasu
2016-01-01
Full Text Available Tissue and matrix stiffness affect cell properties during morphogenesis, cell growth, differentiation, and migration and are altered in the tissue remodeling following injury and the pathological progression. However, detailed molecular mechanisms underlying alterations of stiffness in vivo are still poorly understood. Recent engineering technologies have developed powerful techniques to characterize the mechanical properties of cell and matrix at nanoscale levels. Extracellular matrix (ECM influences mechanical tension and activation of pathogenic signaling during the development of chronic fibrotic diseases. In this short review, we will focus on the present knowledge of the mechanisms of how ECM stiffness is regulated during the development of liver fibrosis and the molecules involved in ECM stiffness as a potential therapeutic target for liver fibrosis.
The measurement of plain weft-knitted fabric stiffness
Haji Mohamad, Ayhan; Cassidy, Thomas; Brydon, Alan; Halley, Dave
2012-05-01
A new instrument and a test method are presented in this paper that can evaluate the stiffness of plain weft-knitted fabrics. The WIRA Instrumentation Tester can measure torsion data for various flexible fibre assemblies whilst they are being twisted. The torsional properties of two types of fabrics, namely nonwoven and knitted fabrics, were analyzed. Then, comparisons between bending rigidity and torsional rigidity have been conducted using FAST-2, Shirley, Heart Loop and the new WIRA method for the assessment of fabric stiffness. The results show high correlation between bending rigidity and torsional rigidity in assessment of nonwoven fabric stiffness; they also reveal that the WIRA tester and torsional rigidity are more suitable for characterizing the stiffness of plain weft-knitted fabrics than the other test methods.
A new variable stiffness suspension system: passive case
O. M. Anubi
2013-02-01
Full Text Available This paper presents the design, analysis, and experimental validation of the passive case of a variable stiffness suspension system. The central concept is based on a recently designed variable stiffness mechanism. It consists of a horizontal control strut and a vertical strut. The main idea is to vary the load transfer ratio by moving the location of the point of attachment of the vertical strut to the car body. This movement is controlled passively using the horizontal strut. The system is analyzed using an L2-gain analysis based on the concept of energy dissipation. The analyses, simulation, and experimental results show that the variable stiffness suspension achieves better performance than the constant stiffness counterpart. The performance criteria used are; ride comfort, characterized by the car body acceleration, suspension deflection, and road holding, characterized by tire deflection.
Mesenchymal stem cell adhesion but not plasticity is affected by high substrate stiffness
Janice Kal Van Tam, Koichiro Uto, Mitsuhiro Ebara, Stefania Pagliari, Giancarlo Forte and Takao Aoyagi
2012-01-01
Full Text Available The acknowledged ability of synthetic materials to induce cell-specific responses regardless of biological supplies provides tissue engineers with the opportunity to find the appropriate materials and conditions to prepare tissue-targeted scaffolds. Stem and mature cells have been shown to acquire distinct morphologies in vitro and to modify their phenotype when grown on synthetic materials with tunable mechanical properties. The stiffness of the substrate used for cell culture is likely to provide cells with mechanical cues mimicking given physiological or pathological conditions, thus affecting the biological properties of cells. The sensitivity of cells to substrate composition and mechanical properties resides in multiprotein complexes called focal adhesions, whose dynamic modification leads to cytoskeleton remodeling and changes in gene expression. In this study, the remodeling of focal adhesions in human mesenchymal stem cells in response to substrate stiffness was followed in the first phases of cell–matrix interaction, using poly-ε-caprolactone planar films with similar chemical composition and different elasticity. As compared to mature dermal fibroblasts, mesenchymal stem cells showed a specific response to substrate stiffness, in terms of adhesion, as a result of differential focal adhesion assembly, while their multipotency as a bulk was not significantly affected by matrix compliance. Given the sensitivity of stem cells to matrix mechanics, the mechanobiology of such cells requires further investigations before preparing tissue-specific scaffolds.
Preliminary study on the effect of stiffness on lamb wave propagation in bovine corneas.
Zhang, Xin-Yu; Yin, Yin; Guo, Yan-Rong; Diao, Xian-Fen; Chen, Xin
2013-01-01
The viscoelastic properties of human cornea could provide valuable information for various clinical applications. Particularly, it will be helpful to achieve a patient-specific biomechanical optimization in LASIK refractive surgery, early detection of corneal ecstatic disease or improved accuracy of intraocular pressure (IOP) measurement. However, there are few techniques that are capable of accurately assessing the corneal elasticity in situ in a nondestructive fashion. In order to develop a quantitative method for assessing both elasticity and viscosity of the cornea, we use ultrasound radiation force to excite Lamb waves in cornea, and a pulse echo transducer to track the tissue vibration. The fresh postmortem bovine eyes were treated via collagen cross-linking to make the cornea stiff. The effect of stiffness was studied by comparing the propagation of Lamb waves in normal and treated corneas. It was found that the waveform of generated Lamb waves changed significantly due to the increase in higher modes in treated corneas. This result indicated that the generated waveform was a complex of multiple harmonics and the varied stiffness will affect the energy distribution over different components. Therefore, it is important for assessing the viscoelastic properties of the cornea to know the components of Lamb wave and calculate the phase velocity appropriately.
Arterial stiffness & Sri Lankan chronic kidney disease of unknown origin
Fiona Gifford; Robert Kimmitt; Chula Herath; Webb, David J.; Vanessa Melville; Sisira Siribaddana; Michael Eddleston; Neeraj Dhaun
2016-01-01
Chronic kidney disease (CKD) is common and independently associated with cardiovascular disease (CVD). Arterial stiffness contributes to CVD risk in CKD. In many developing countries a considerable proportion of CKD remains unexplained, termed CKDu. We assessed arterial stiffness in subjects with Sri Lankan CKDu, in matched controls without CKD and in those with defined CKD. Aortic blood pressure (BP), pulse wave velocity (PWV) and augmentation index (AIx) were assessed in 130 subjects (50 wi...
Substrate stiffness regulates extracellular matrix deposition by alveolar epithelial cells
Jessica L Eisenberg
2011-01-01
Full Text Available Jessica L Eisenberg1,2, Asmahan Safi3, Xiaoding Wei3, Horacio D Espinosa3, GR Scott Budinger2, Desire Takawira1, Susan B Hopkinson1, Jonathan CR Jones1,21Department of Cell and Molecular Biology, 2Division of Pulmonary Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; 3Department of Mechanical Engineering, Northwestern University, Evanston, IL, USAAim: The aim of the study was to address whether a stiff substrate, a model for pulmonary fibrosis, is responsible for inducing changes in the phenotype of alveolar epithelial cells (AEC in the lung, including their deposition and organization of extracellular matrix (ECM proteins.Methods: Freshly isolated lung AEC from male Sprague Dawley rats were seeded onto polyacrylamide gel substrates of varying stiffness and analyzed for expression and organization of adhesion, cytoskeletal, differentiation, and ECM components by Western immunoblotting and confocal immunofluorescence microscopy.Results: We observed that substrate stiffness influences cell morphology and the organization of focal adhesions and the actin cytoskeleton. Surprisingly, however, we found that substrate stiffness has no influence on the differentiation of type II into type I AEC, nor does increased substrate stiffness lead to an epithelial–mesenchymal transition. In contrast, our data indicate that substrate stiffness regulates the expression of the α3 laminin subunit by AEC and the organization of both fibronectin and laminin in their ECM.Conclusions: An increase in substrate stiffness leads to enhanced laminin and fibronectin assembly into fibrils, which likely contributes to the disease phenotype in the fibrotic lung.Keywords: alveolar epithelial cells, fibrosis, extracellular matrix, substrate stiffness
Stiffness selection in synthesis of mechatronic discrete systems
Buchacz, Andrzej; Gałęziowski, Damian
2016-11-01
In the paper, the known algorithm of designing of mechatronic discrete systems has been decomposed. As a result, detailed analysis of stiffness selection, during the process of distribution of dynamical characteristics functions, has been done. Based on synthesized one degree of freedom system that utilize piezostack actuator, detailed constrains related to the stiffness and their impact for mechanical, dimensionless and mechatronic parameters, have been investigated. The work extends the known problem of vibration control in discrete mechatronic systems
Weak gravity conjecture and effective field theory
Saraswat, Prashant
2017-01-01
The weak gravity conjecture (WGC) is a proposed constraint on theories with gauge fields and gravity, requiring the existence of light charged particles and/or imposing an upper bound on the field theory cutoff Λ . If taken as a consistency requirement for effective field theories (EFTs), it rules out possibilities for model building including some models of inflation. I demonstrate simple models which satisfy all forms of the WGC, but which through Higgsing of the original gauge fields produce low-energy EFTs with gauge forces that badly violate the WGC. These models illustrate specific loopholes in arguments that motivate the WGC from a bottom-up perspective; for example the arguments based on magnetic monopoles are evaded when the magnetic confinement that occurs in a Higgs phase is accounted for. This indicates that the WGC should not be taken as a veto on EFTs, even if it turns out to be a robust property of UV quantum gravity theories. However, if the latter is true, then parametric violation of the WGC at low energy comes at the cost of nonminimal field content in the UV. I propose that only a very weak constraint is applicable to EFTs, Λ ≲(log 1/g )-1 /2Mpl , where g is the gauge coupling, motivated by entropy bounds. Remarkably, EFTs produced by Higgsing a theory that satisfies the WGC can saturate but not violate this bound.
Do weak global stresses synchronize earthquakes?
Bendick, R.; Bilham, R.
2017-08-01
Insofar as slip in an earthquake is related to the strain accumulated near a fault since a previous earthquake, and this process repeats many times, the earthquake cycle approximates an autonomous oscillator. Its asymmetric slow accumulation of strain and rapid release is quite unlike the harmonic motion of a pendulum and need not be time predictable, but still resembles a class of repeating systems known as integrate-and-fire oscillators, whose behavior has been shown to demonstrate a remarkable ability to synchronize to either external or self-organized forcing. Given sufficient time and even very weak physical coupling, the phases of sets of such oscillators, with similar though not necessarily identical period, approach each other. Topological and time series analyses presented here demonstrate that earthquakes worldwide show evidence of such synchronization. Though numerous studies demonstrate that the composite temporal distribution of major earthquakes in the instrumental record is indistinguishable from random, the additional consideration of event renewal interval serves to identify earthquake groupings suggestive of synchronization that are absent in synthetic catalogs. We envisage the weak forces responsible for clustering originate from lithospheric strain induced by seismicity itself, by finite strains over teleseismic distances, or by other sources of lithospheric loading such as Earth's variable rotation. For example, quasi-periodic maxima in rotational deceleration are accompanied by increased global seismicity at multidecadal intervals.
Droplet breakup dynamics of weakly viscoelastic fluids
Marshall, Kristin; Walker, Travis
2016-11-01
The addition of macromolecules to solvent, even in dilute quantities, can alter a fluid's response in an extensional flow. For low-viscosity fluids, the presence of elasticity may not be apparent when measured using a standard rotational rheometer, yet it may still alter the response of a fluid when undergoing an extensional deformation, especially at small length scales where elastic effects are enhanced. Applications such as microfluidics necessitate investigating the dynamics of fluids with elastic properties that are not pronounced at large length scales. In the present work, a microfluidic cross-slot configuration is used to study the effects of elasticity on droplet breakup. Droplet breakup and the subsequent iterated-stretching - where beads form along a filament connecting two primary droplets - were observed for a variety of material and flow conditions. We present a relationship on the modes of bead formation and how and when these modes will form based on key parameters such as the properties of the outer continuous-phase fluid. The results are vital not only for simulating the droplet breakup of weakly viscoelastic fluids but also for understanding how the droplet breakup event can be used for characterizing the extensional properties of weakly-viscoelastic fluids.
Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases
Ioana Mozos
2017-08-01
Full Text Available Arterial stiffness predicts an increased risk of cardiovascular events. Inflammation plays a major role in large arteries stiffening, related to atherosclerosis, arteriosclerosis, endothelial dysfunction, smooth muscle cell migration, vascular calcification, increased activity of metalloproteinases, extracellular matrix degradation, oxidative stress, elastolysis, and degradation of collagen. The present paper reviews main mechanisms explaining the crosstalk between inflammation and arterial stiffness and the most common inflammatory markers associated with increased arterial stiffness, considering the most recent clinical and experimental studies. Diverse studies revealed significant correlations between the severity of arterial stiffness and inflammatory markers, such as white blood cell count, neutrophil/lymphocyte ratio, adhesion molecules, fibrinogen, C-reactive protein, cytokines, microRNAs, and cyclooxygenase-2, in patients with a broad variety of diseases, such as metabolic syndrome, diabetes, coronary heart disease, peripheral arterial disease, malignant and rheumatic disorders, polycystic kidney disease, renal transplant, familial Mediterranean fever, and oral infections, and in women with preeclampsia or after menopause. There is strong evidence that inflammation plays an important and, at least, partly reversible role in the development of arterial stiffness, and inflammatory markers may be useful additional tools in the assessment of the cardiovascular risk in clinical practice. Combined assessment of arterial stiffness and inflammatory markers may improve non-invasive assessment of cardiovascular risk, enabling selection of high-risk patients for prophylactic treatment or more regular medical examination. Development of future destiffening therapies may target pro-inflammatory mechanisms.
Non-crossbridge stiffness in active muscle fibres.
Colombini, Barbara; Nocella, Marta; Bagni, Maria Angela
2016-01-01
Stretching of an activated skeletal muscle induces a transient tension increase followed by a period during which the tension remains elevated well above the isometric level at an almost constant value. This excess of tension in response to stretching has been called 'static tension' and attributed to an increase in fibre stiffness above the resting value, named 'static stiffness'. This observation was originally made, by our group, in frog intact muscle fibres and has been confirmed more recently, by us, in mammalian intact fibres. Following stimulation, fibre stiffness starts to increase during the latent period well before crossbridge force generation and it is present throughout the whole contraction in both single twitches and tetani. Static stiffness is dependent on sarcomere length in a different way from crossbridge force and is independent of stretching amplitude and velocity. Static stiffness follows a time course which is distinct from that of active force and very similar to the myoplasmic calcium concentration time course. We therefore hypothesize that static stiffness is due to a calcium-dependent stiffening of a non-crossbridge sarcomere structure, such as the titin filament. According to this hypothesis, titin, in addition to its well-recognized role in determining the muscle passive tension, could have a role during muscle activity.
Evaluation of arterial stiffness in nondiabetic chronic kidney disease patients
Bodanapu Mastanvalli
2017-01-01
Full Text Available Chronic kidney disease (CKD is a growing problem worldwide. Clinical and epidemiologic studies have shown that structural and functional changes that occur in major arteries are a major contributing factor to the high mortality in uremic patients. Recent studies have shown a stepwise increase of the carotid-femoral pulse wave velocity (cfPWV from CKD Stage 1 to Stage 5. We evaluated the cfPWV and augmentation index (AIx, as indirect markers of arterial stiffness in patients with nondiabetic CKD and compared the values with normal population; we also evaluated the relationship between various stages of CKD and arterial stiffness markers. This cross-sectional study was carried out in the Department of Nephrology for a duration of two years from January 15, 2012, to January 14, 2014. Fifty patients with nondiabetic CKD were studied along with 50 healthy volunteers who did not have CKD, who served as controls. Assessment of arterial stiffness (blood pressure, PWV, heart rate, aortic augmentation pressure, and AIx was performed using the PeriScope device. PWV positively correlated with systolic and diastolic blood pressure, mean aortic arterial pressure, serum creatinine, and serum uric acid and negatively correlated with estimated glomerular filtration rate. Arterial stiffness increased as CKD stage increased and was higher in nondiabetic CKD group than in the general population. Arterial stiffness progressed gradually from CKD Stage 2 to 5, and then abruptly, in dialysis patients. Measures to decrease the arterial stiffness and its influence on decreasing cardiovascular events need further evaluation.
A multiwell platform for studying stiffness-dependent cell biology.
Justin D Mih
Full Text Available Adherent cells are typically cultured on rigid substrates that are orders of magnitude stiffer than their tissue of origin. Here, we describe a method to rapidly fabricate 96 and 384 well platforms for routine screening of cells in tissue-relevant stiffness contexts. Briefly, polyacrylamide (PA hydrogels are cast in glass-bottom plates, functionalized with collagen, and sterilized for cell culture. The Young's modulus of each substrate can be specified from 0.3 to 55 kPa, with collagen surface density held constant over the stiffness range. Using automated fluorescence microscopy, we captured the morphological variations of 7 cell types cultured across a physiological range of stiffness within a 384 well plate. We performed assays of cell number, proliferation, and apoptosis in 96 wells and resolved distinct profiles of cell growth as a function of stiffness among primary and immortalized cell lines. We found that the stiffness-dependent growth of normal human lung fibroblasts is largely invariant with collagen density, and that differences in their accumulation are amplified by increasing serum concentration. Further, we performed a screen of 18 bioactive small molecules and identified compounds with enhanced or reduced effects on soft versus rigid substrates, including blebbistatin, which abolished the suppression of lung fibroblast growth at 1 kPa. The ability to deploy PA gels in multiwell plates for high throughput analysis of cells in tissue-relevant environments opens new opportunities for the discovery of cellular responses that operate in specific stiffness regimes.
Rotational and peak torque stiffness of rugby shoes.
Ballal, Moez S; Usuelli, Federico Giuseppe; Montrasio, Umberto Alfieri; Molloy, Andy; La Barbera, Luigi; Villa, Tomaso; Banfi, Giuseppe
2014-09-01
Sports people always strive to avoid injury. Sports shoe designs in many sports have been shown to affect traction and injury rates. The aim of this study is to demonstrate the differing stiffness and torque in rugby boots that are designed for the same effect. Five different types of rugby shoes commonly worn by scrum forwards were laboratory tested for rotational stiffness and peak torque on a natural playing surface generating force patterns that would be consistent with a rugby scrum. The overall internal rotation peak torque was 57.75±6.26 Nm while that of external rotation was 56.55±4.36 Nm. The Peak internal and external rotational stiffness were 0.696±0.1 and 0.708±0.06 Nm/deg respectively. Our results, when compared to rotational stiffness and peak torques of football shoes published in the literature, show that shoes worn by rugby players exert higher rotational and peak torque stiffness compared to football shoes when tested on the same natural surfaces. There was significant difference between the tested rugby shoes brands. In our opinion, to maximize potential performance and lower the potential of non-contact injury, care should be taken in choosing boots with stiffness appropriate to the players main playing role. Copyright © 2014 Elsevier Ltd. All rights reserved.
Leg stiffness of sprinters using running-specific prostheses
McGowan, Craig P.; Grabowski, Alena M.; McDermott, William J.; Herr, Hugh M.; Kram, Rodger
2012-01-01
Running-specific prostheses (RSF) are designed to replicate the spring-like nature of biological legs (bioL) during running. However, it is not clear how these devices affect whole leg stiffness characteristics or running dynamics over a range of speeds. We used a simple spring–mass model to examine running mechanics across a range of speeds, in unilateral and bilateral transtibial amputees and performance-matched controls. We found significant differences between the affected leg (AL) of unilateral amputees and both ALs of bilateral amputees compared with the bioL of non-amputees for nearly every variable measured. Leg stiffness remained constant or increased with speed in bioL, but decreased with speed in legs with RSPs. The decrease in leg stiffness in legs with RSPs was mainly owing to a combination of lower peak ground reaction forces and increased leg compression with increasing speeds. Leg stiffness is an important parameter affecting contact time and the force exerted on the ground. It is likely that the fixed stiffness of the prosthesis coupled with differences in the limb posture required to run with the prosthesis limits the ability to modulate whole leg stiffness and the ability to apply high vertical ground reaction forces during sprinting. PMID:22337629
Sex Differences in Limb and Joint Stiffness in Recreational Runners
Sinclair Jonathan
2015-09-01
Full Text Available Purpose. Female runners are known to be at greater risk from chronic running injuries than age-matched males, although the exact mechanisms are often poorly understood. The aim of the current investigation was to determine if female recreational runners exhibit distinct limb and joint stiffness characteristics in relation to their male counterparts. Methods. Fourteen male and fourteen female runners ran over a force platform at 4.0 m · s-1. Lower limb kinematics were collected using an eight-camera optoelectric motion capture system operating at 250 Hz. Measures of limb and joint stiffness were calculated as a function of limb length and joint moments divided by the extent of limb and joint excursion. All stiffness and joint moment parameters were normalized to body mass. Sex differences in normalized limb and knee and ankle joint stiffness were examined statistically using independent samples t tests. Results. The results indicate that normalized limb (male = 0.18 ± 0.07, female = 0.37 ± 0.10 kN · kg · m-1 and knee stiffness (male = 5.59 ± 2.02, female = 7.34 ± 1.78 Nm · kg · rad-1 were significantly greater in female runners. Conclusions. On the basis that normalized knee and limb stiffness were shown to be significantly greater in female runners, the findings from the current investigation may provide further insight into the aetiology of the distinct injury patterns observed between sexes.
Stiffness mapping prostate biopsy samples using a tactile sensor.
Peng, Qiyu; Omata, Sadao; Peehl, Donna M; Constantinou, Chris E
2011-01-01
Previous studies have demonstrated that the stiffness of cancerous cells reflects their pathological stage and progression rates, with increased cancerous cell stiffness associated with increased aggressiveness. Therefore, the elasticity of the cancerous cells has the potential to be used as an indicator of the cancer's aggressiveness. However, the sensitivity and resolution of current palpation and imaging techniques are not sufficient to detect small cancerous tissues. In previous studies, we developed a tactile-based device to map with high resolution the stiffness of a tissue section. The purpose of this study is to evaluate this device using different tissues (BPH, Cancer and PZ) collected from human prostates. The preliminary results show that the tactile device is sensitive enough to tell the differences of the stiffness of different tissues. The results also disclosed the factors (humidity, temperature and tissue degradation) which could dramatically affect the results of stiffness mapping. The tactile technology described in this paper has the potential to help disclose the underlying mechanical mechanisms that lead to increased stiffness in prostate tumors.
Ambike, S; Zhou, T; Zatsiorsky, V M; Latash, M L
2015-07-01
This study used the framework of the referent configuration hypothesis and slow changes in the external conditions during vertical oscillation of a hand-held object to infer the characteristics of hypothetical control variables. The study had two main objectives: (1) to show that hypothetical control variables, namely, referent coordinates and apparent stiffness of vertical hand position and grip force can be measured in an experiment; and (2) to establish relation(s) between these control variables that yield the classic grip-force-load-force coupling. Healthy subjects gripped a handle and performed vertical oscillations between visual targets at one of five metronome-prescribed frequencies. A HapticMaster robot was used to induce slow changes in the vertical force applied to the handle, while the size of the handle was changed slowly leading to changes in the grip aperture. The subjects were instructed not to react to possible changes in the external forces. A linear, second-order model was used to reconstruct the referent coordinate and apparent stiffness values for each phase of the vertical oscillation cycle using across-cycle regressions. The reconstructed time profiles of the referent coordinates and apparent stiffness showed consistent trends across subjects and movement frequencies. To validate the method, these values were used to predict the vertical force and the grip force applied to the handle for movement cycles that were not utilized in the reconstruction process. Analysis of the coupling between the four variables, two referent coordinates and two apparent stiffness values, revealed a single strong constraint reflecting the coupling between the grip force and vertical force. We view these data as providing experimental support for the idea of controlling natural, multi-muscle actions with shifts in a low-dimensional set of referent coordinates.
Modeling, Modal Properties, and Mesh Stiffness Variation Instabilities of Planetary Gears
Parker, Robert G.; Lin, Jian; Krantz, Timothy L. (Technical Monitor)
2001-01-01
Planetary gear noise and vibration are primary concerns in their applications in helicopters, automobiles, aircraft engines, heavy machinery and marine vehicles. Dynamic analysis is essential to the noise and vibration reduction. This work analytically investigates some critical issues and advances the understanding of planetary gear dynamics. A lumped-parameter model is built for the dynamic analysis of general planetary gears. The unique properties of the natural frequency spectra and vibration modes are rigorously characterized. These special structures apply for general planetary gears with cyclic symmetry and, in practically important case, systems with diametrically opposed planets. The special vibration properties are useful for subsequent research. Taking advantage of the derived modal properties, the natural frequency and vibration mode sensitivities to design parameters are investigated. The key parameters include mesh stiffnesses, support/bearing stiffnesses, component masses, moments of inertia, and operating speed. The eigen-sensitivities are expressed in simple, closed-form formulae associated with modal strain and kinetic energies. As disorders (e.g., mesh stiffness variation. manufacturing and assembling errors) disturb the cyclic symmetry of planetary gears, their effects on the free vibration properties are quantitatively examined. Well-defined veering rules are derived to identify dramatic changes of natural frequencies and vibration modes under parameter variations. The knowledge of free vibration properties, eigen-sensitivities, and veering rules provide important information to effectively tune the natural frequencies and optimize structural design to minimize noise and vibration. Parametric instabilities excited by mesh stiffness variations are analytically studied for multi-mesh gear systems. The discrepancies of previous studies on parametric instability of two-stage gear chains are clarified using perturbation and numerical methods. The
Stiffness comparison of mushroom and straight SS and TMA lingual archwires.
Lombardo, Luca; Carlucci, Antonella; Palone, Mario; Mollica, Francesco; Siciliani, Giuseppe
2016-12-01
The aim of this study is to investigate the relative stiffness of straight and mushroom lingual archwires of different diameters, cross sections and alloys, plotting their load/deflection graphs and using a modified three-point bending test. Fujita's mushroom archwires and straight lingual archwires of different diameters, cross sections and alloys were derived by a virtual set-up of an equal malocclusion and were cut at their straight distal portion. These distal portions were tested using a modified three-point bending test by an Instron 4467 dynamometer and the forces, were exerted at 1-mm deflection and were compared on each resulting load/deflection curve by means of ANOVA (p < 0.05). All upper lingual mushroom wires exerted significantly lower forces than the straight wire. Lower mushroom archwires were stiffer than their upper counterparts, which were longer and featured inset bends. In the lower arch, similar levels of forces were recorded for the two types of wire. Load-deflection curves were higher for the straight wires, and stiffness increased proportionally with their diameter. The stiffness of an archwire is a function of its diameter, length and the alloy it is made from. In lower lingual wires, there is little difference in stiffness between mushroom and straight wires, but in upper wires, the straight version is considerably stiffer. The greater bearing effect exhibited by the straight wire in the working and finishing phases makes it less susceptible to bowing effect and therefore preferable for sliding mechanics during en masse retraction, particularly in the upper arch.
Biological effects due to weak magnetic field on plants
Belyavskaya, N. A.
2004-01-01
Throughout the evolution process, Earth's magnetic field (MF, about 50 μT) was a natural component of the environment for living organisms. Biological objects, flying on planned long-term interplanetary missions, would experience much weaker magnetic fields, since galactic MF is known to be 0.1-1 nT. However, the role of weak magnetic fields and their influence on functioning of biological organisms are still insufficiently understood, and is actively studied. Numerous experiments with seedlings of different plant species placed in weak magnetic field have shown that the growth of their primary roots is inhibited during early germination stages in comparison with control. The proliferative activity and cell reproduction in meristem of plant roots are reduced in weak magnetic field. Cell reproductive cycle slows down due to the expansion of G 1 phase in many plant species (and of G 2 phase in flax and lentil roots), while other phases of cell cycle remain relatively stabile. In plant cells exposed to weak magnetic field, the functional activity of genome at early pre-replicate period is shown to decrease. Weak magnetic field causes intensification of protein synthesis and disintegration in plant roots. At ultrastructural level, changes in distribution of condensed chromatin and nucleolus compactization in nuclei, noticeable accumulation of lipid bodies, development of a lytic compartment (vacuoles, cytosegresomes and paramural bodies), and reduction of phytoferritin in plastids in meristem cells were observed in pea roots exposed to weak magnetic field. Mitochondria were found to be very sensitive to weak magnetic field: their size and relative volume in cells increase, matrix becomes electron-transparent, and cristae reduce. Cytochemical studies indicate that cells of plant roots exposed to weak magnetic field show Ca 2+ over-saturation in all organelles and in cytoplasm unlike the control ones. The data presented suggest that prolonged exposures of plants to weak
Santos, Gilmar F; Gomes, Aline A; Sacco, Isabel C N; Ackermann, Marko
2017-08-01
Diabetic neuropathic individuals present massive muscle strength reduction at the ankle plantar- and dorsiflexors and increased joint stiffness. Our aim is to investigate the adaptation strategies to these musculoskeletal alterations during walking by means of predictive simulations. We used a seven segment planar musculoskeletal model actuated by eight Hill-type muscles in each leg. The effect of all passive tissue in muscles and other joint structures was modeled by net passive joint moment curves. The predictive simulations were generated by solving an optimal control problem that minimized a cost function, including effort and tracking terms, using direct collocation and a commercial optimal control package. We simulate four conditions to represent the weakening of the distal muscles triceps sural (TS) and tibialis anterior (TA), and five conditions to represent the effect of increasing nonlinear ankle stiffness in flexion. The weakening of the distal muscles leads to a delayed action of the TS and a progressive decrease of the gastrocnemius peak force in the push-off phase. This distal deficit is compensated by a larger hip flexion moment resulting from an increase in the iliopsoas muscle force in this phase, known as the hip strategy. The adaptation mechanisms observed in response to an increase in ankle stiffness include the hip strategy and the exploitation of the passive joint structures as springs, which store energy during midstance and release it during push-off, reducing TS force and power in this phase and leading to a consistent decrease in the overall muscle force levels. Copyright © 2017 Elsevier B.V. All rights reserved.
Loram, Ian D; Lakie, Martin
2002-12-15
During quiet standing the human "inverted pendulum" sways irregularly. In previous work where subjects balanced a real inverted pendulum, we investigated what contribution the intrinsic mechanical ankle stiffness makes to achieve stability. Using the results of a plausible model, we suggested that intrinsic ankle stiffness is inadequate for providing stability. Here, using a piezo-electric translator we applied small, unobtrusive mechanical perturbations to the foot while the subject was standing freely. These short duration perturbations had a similar size and velocity to movements which occur naturally during quiet standing, and they produced no evidence of any stretch reflex response in soleus, or gastrocnemius. Direct measurement confirms our earlier conclusion; intrinsic ankle stiffness is not quite sufficient to stabilise the body or pendulum. On average the directly determined intrinsic stiffness is 91 +/- 23 % (mean +/- S.D.) of that necessary to provide minimal stabilisation. The stiffness was substantially constant, increasing only slightly with ankle torque. This stiffness cannot be neurally regulated in quiet standing. Thus we attribute this stiffness to the foot, Achilles' tendon and aponeurosis rather than the activated calf muscle fibres. Our measurements suggest that the triceps surae muscles maintain balance via a spring-like element which is itself too compliant to guarantee stability. The implication is that the brain cannot set ankle stiffness and then ignore the control task because additional modulation of torque is required to maintain balance. We suggest that the triceps surae muscles maintain balance by predictively controlling the proximal offset of the spring-like element in a ballistic-like manner.
Water Sorption and Hindered Diffusion with Different Chain Stiffness of Superabsorbent Polymer
Chun, Myung-Suk; Lee, Dae-Young [Korea Institute of Science and Technology, Seoul (Korea, Republic of)
2015-01-15
Water sorption and diffusion are essential physicochemical properties of a high-performance superabsorbent polymer (SAP). We combine the Park model with the obstruction-scaling model and the water clustering in confined spaces of the polymer hydrogel. Special attention is focused on elucidating the effect of chain stiffness by considering the conformation of the polymer chain. Theoretical model parameters are determined from the best fits by simultaneous nonlinear regressions for both sorption and corrected diffusion data based on previous experiments with poly(acrylamide-co-sodium acrylate) hydrogel. Predictions show that the hindered water diffusivity leads to a sigmoid curve with relative humidity a{sub w}, where it increases monotonically up to aw{sub ≅} 0.6 due to the swelling but decreases at higher a{sub w} caused by water clustering. Water diffusion decreases with increasing chain stiffness, and the larger persistence length provides a smaller opening radius in void spaces regarding the weak elastic deformation of hydrogel under the applied stress.
Optimal Load and Stiffness for Displacement-Constrained Vibration Energy Harvesters
Halvorsen, Einar
2016-01-01
The power electronic interface to a vibration energy harvester not only provides ac-dc conversion, but can also set the electrical damping to maximize output power under displacement-constrained operation. This is commonly exploited for linear two-port harvesters by synchronous switching to realize a Coulomb-damped resonant generator, but has not been fully explored when the harvester is asynchronously switched to emulate a resistive load. In order to understand the potential of such an approach, the optimal values of load resistance and other control parameters need to be known. In this paper we determine analytically the optimal load and stiffness of a harmonically driven two-port harvester with displacement constraints. For weak-coupling devices, we do not find any benefit of load and stiffness adjustment beyond maintaining a saturated power level. For strong coupling we find that the power can be optimized to agree with the velocity damped generator beyond the first critical force for displacement-constra...
Elastic metamaterials for independent realization of negativity in density and stiffness.
Oh, Joo Hwan; Kwon, Young Eui; Lee, Hyung Jin; Kim, Yoon Young
2016-03-23
In this paper, we present the first realization of an elastic metamaterial allowing independent tuning of negative density and stiffness for elastic waves propagating along a designated direction. In electromagnetic (or acoustic) metamaterials, it is now possible to tune permittivity (bulk modulus) and permeability (density) independently. Apparently, the tuning methods seem to be directly applicable for elastic case, but no realization has yet been made due to the unique tensorial physics of elasticity that makes wave motions coupled in a peculiar way. To realize independent tunability, we developed a single-phased elastic metamaterial supported by theoretical analysis and numerical/experimental validations.
Strengths, weaknesses, opportunities and threats
Bull, J. W.; Jobstvogt, N.; Böhnke-Henrichs, A.;
2016-01-01
environmental awareness. Threats include resistance to change, and difficulty with interdisciplinary collaboration. Consideration of SWOT themes suggested five strategic areas for developing and implementing ES.The ES concept could improve decision-making related to natural resource use, and interpretation...... facilitate interdisciplinary research, ensuring decision-making that supports sustainable development........ Such an assessment could form the basis for improving ES thinking, further embedding it into environmental decisions and management.The Young Ecosystem Services Specialists (YESS) completed a Strengths-Weaknesses-Opportunities-Threats (SWOT) analysis of ES through YESS member surveys. Strengths include the approach...
Weak Precedence Story Parsing Grammar
张松懋
1995-01-01
Story understanding is one of the important branches of natural language understanding research in AI techniques.The story understanding approach based on Story Parsing Grammar (SPG) involves that SPG is used to represent different abstracting processes of stories with different levels in story understanding and that the story understanding process is converted to the recognition process of stories using the syntactic parser of SPG.This kind of story understanding is called story parsing.In this paper,firstly a subclass of SPG,called Weak Precedence SPG(WPSPG),is defined.Afterwards the syntactic parsing algorithm of WPSPG is studied.An example of story parsing is also given.
Weakly distributive domains(Ⅱ)
JIANG Ying; ZHANG Guo-Qiang
2007-01-01
In our previous work(Inform.and Comput.,2005,202:87-103),we have shown that for any ω-algebraic meet-cpo D,if all higher-order stable function spaces built from D are ω-algebraic,then D is finitary.This accomplishes the first of a possible,two-step process in solving the problem raised(LNCS,1991,530:16-33;Domainsand lambda-calculi,Cambridge Univ.Press,1998)whetherthe category of stable bifinite domains of Amadio-Droste-G(o)bel(LNCS,1991,530:16-33;Theor.Comput.Sci.,1993,111:89-101)is the largest cartesian closed full subcategory within the category of ω-algebraic meet-cpos with stable functions.This paper presents the results of the second step,which is to show that for any ω-algebraic meet-cpo D satisfying axioms M and I to be contained in a cartesian closed full sub-category using ω-algebraic meet-cpos with stable functions,it must not violate M I∞.We introduce a new class of domains called weakly distributive domains and show that for these domains to be in a cartesian closed category using ω-algebraic meet-cpos,property M I must not be violated.Further,we demonstrate that principally distributive domains(those for which each principle ideal is distributive)form a proper subclass of weakly distributive domains,and Birkhoff's M3 and N5(Introduction to Lattices and order,Cambridge Univ.Press,2002)are weakly distributive(but non-distributive).Then,we establish characterization results for weakly distributive domains.We also introduce the notion of meet-generators in constructing stable functions and show that if an ω-algebraic meet-cpo D contains an infinite number of meet-generators,then[D→D]fails I.However,the original problem of Amadio and Curien remains open.
Alvarez, Daniel; Orozco, Federico; Mella, José María; Anders, Maria; Antinucci, Florencia; Mastai, Ricardo
2015-01-01
The introduction of noninvasive liver stiffness (LS) determination has heralded a new stage in the diagnosis and treatment of liver fibrosis. We evaluated the effect of food intake on LS in patients with different degrees of liver disease. We evaluated 24 patients (F≤1, n=11 and F> 1, n=13). LS (Fibroscan®) and portal blood flow (PBF) (Doppler ultrasound) were studied before and 30min after ingestion of a standard liquid meal. Food intake increased PBF (51±10%, p1). Hemodynamic and LS values returned to baseline pre-meal levels within 2hours. LS increases markedly after ingestion of a standard meal, irrespective of the degree of fibrosis. Our results strongly suggest that LS should be measured in fasting conditions. Copyright © 2015 Elsevier España, S.L.U. and AEEH y AEG. All rights reserved.
Optimal Weak Lensing Skewness Measurements
Zhang, T J; Zhang, P; Dubinski, J; Zhang, Tong-Jie; Pen, Ue-Li; Zhang, Pengjie; Dubinski, John
2003-01-01
Weak lensing measurements are entering a precision era to statistically map the distribution of matter in the universe. The most common measurement has been of the variance of the projected surface density of matter, which corresponds to the induced correlation in alignments of background galaxies. This measurement of the fluctuations is insensitive to the total mass content, like using waves on the ocean to measure its depths. But when the depth is shallow as happens near a beach, waves become skewed. Similarly, a measurement of skewness in the projected matter distribution directly measures the total matter content of the universe. While skewness has already been convincingly detected, its constraint on cosmology is still weak. We address optimal analyses for the CFHT Legacy Survey in the presence of noise. We show that a compensated Gaussian filter with a width of 2.5 arc minutes optimizes the cosmological constraint, yielding $\\Delta \\Omega_m/\\Omega_m\\sim 10%$. This is significantly better than other filt...
Hall, Lawrence J.; Pinner, David; Ruderman, Joshua T.
2014-12-01
The measured values of the weak scale, v, and the first generation masses, m u, d, e , are simultaneously explained in the multiverse, with all these parameters scanning independently. At the same time, several remarkable coincidences are understood. Small variations in these parameters away from their measured values lead to the instability of hydrogen, the instability of heavy nuclei, and either a hydrogen or a helium dominated universe from Big Bang Nucleosynthesis. In the 4d parameter space of ( m u , m d , m e , v), catastrophic boundaries are reached by separately increasing each parameter above its measured value by a factor of (1.4, 1.3, 2.5, ˜ 5), respectively. The fine-tuning problem of the weak scale in the Standard Model is solved: as v is increased beyond the observed value, it is impossible to maintain a significant cosmological hydrogen abundance for any values of m u, d, e that yield both hydrogen and heavy nuclei stability.
Weak Quasielastic Production of Hyperons
Athar, M Sajjad; Alam, M Rafi; Chauhan, S; Singh, S K
2016-01-01
We present the results for antineutrino induced quasielastic hyperon production from nucleon and nuclear targets \\cite{Alam:2014bya,Singh:2006xp}. The inputs are the nucleon-hyperon(N--Y) transition form factors determined from the analysis of neutrino-nucleon scattering and semileptonic decays of neutron and hyperons using SU(3) symmetry. The calculations for the nuclear targets are done in local density approximation. The nuclear medium effects(NME) like Fermi motion, Pauli blocking and final state interaction(FSI) effects due to hyperon-nucleon scattering have been taken into account. The hyperons giving rise to pions through weak decays also contribute to the weak pion production in addition to the $\\Delta$ excitation mechanism which dominates in the energy region of $<$ 0.7 GeV. We also present the results of longitudinal and perpendicular components of polarization of final hyperon \\cite{Akbar:2016awk}. These measurements in the future accelerator experiments with antineutrinos may give some informat...
Weak lensing and cosmological investigation
Acquaviva, V
2005-01-01
In the last few years the scientific community has been dealing with the challenging issue of identifying the dark energy component. We regard weak gravitational lensing as a brand new, and extremely important, tool for cosmological investigation in this field. In fact, the features imprinted on the cosmic microwave background radiation by the lensing from the intervening distribution of matter represent a pretty unbiased estimator, and can thus be used for putting constraints on different dark energy models. This is true in particular for the magnetic-type B-modes of CMB polarization, whose unlensed spectrum at large multipoles (l approximately=1000) is very small even in presence of an amount of gravitational waves as large as currently allowed by the experiments: therefore, on these scales the lensing phenomenon is the only responsible for the observed power, and this signal turns out to be a faithful tracer of the dark energy dynamics. We first recall the formal apparatus of the weak lensing in extended t...
Political corruption and weak state
Stojiljković Zoran
2013-01-01
Full Text Available The author starts from the hypothesis that it is essential for the countries of the region to critically assess the synergy established between systemic, political corruption and a selectively weak, “devious” nature of the state. Moreover, the key dilemma is whether the expanded practice of political rent seeking supports the conclusion that the root of all corruption is in the very existence of the state - particularly in excessive, selective and deforming state interventions and benefits that create a fertile ground for corruption? The author argues that the destructive combination of weak government and rampant political corruption is based on scattered state intervention, while also rule the parties cartel in the executive branch subordinate to parliament, the judiciary and the police. Corrupt exchange takes place with the absence of strong institutional framework and the precise rules of the political and electoral games, control of public finances and effective political and anti-monopoly legislation and practice included. Exit from the current situation can be seen in the realization of effective anticorruption strategy that integrates preventive and repressive measures and activities and lead to the establishment of principles of good governance. [Projekat Ministarstva nauke Republike Srbije, br. 179076: Politički identitet Srbije u regionalnom i globalnom kontekstu
Eliana Henriques de Brito
1990-01-01
Full Text Available In continuing from previous papers, where we studied the existence and uniqueness of the global solution and its asymptotic behavior as time t goes to infinity, we now search for a time-periodic weak solution u(t for the equation whose weak formulation in a Hilbert space H isddt(u′,v+δ(u′,v+αb(u,v+βa(u,v+(G(u,v=(h,vwhere: ′=d/dt; (′ is the inner product in H; b(u,v, a(u,v are given forms on subspaces U⊂W, respectively, of H; δ>0, α≥0, β≥0 are constants and α+β>0; G is the Gateaux derivative of a convex functional J:V⊂H→[0,∞ for V=U, when α>0 and V=W when α=0, hence β>0; v is a test function in V; h is a given function of t with values in H.
Human plantarflexor stiffness to multiple single-stretch trials.
Blanpied, P; Smidt, G L
1992-01-01
The purpose of this investigation was to determine the influence of different stretch velocities, different rates of pre-stretch force development, and different pre-stretch muscle lengths on the intrinsic stiffness exhibited by the quasi-statically contracting active human plantarflexors during multiple single-stretch trials at 20-60% of maximum isometric contraction. Subjects were positioned prone, with the knee flexed 1.57 rad(90 degrees), shank stabilized, and foot secured in a hard plastic orthotic. Slowly increasing isometric plantarflexion force was produced until the plantarflexors were stretched by a rapid 0.2 rad (12 degrees) dorsiflexion movement. Plantarflexion forces and ankle positions were determined during these stretches as well as during resting stretches when the muscle was inactive. Resting forces were subtracted from the active trials, forces converted to torques, and stiffnesses determined for the first 62 ms of the stretch. The slope of the stiffness vs pre-stretch torque relationship averaged 4.30 +/- 0.34 Nm rad-1 Nm-1. Little difference was found between stiffness determined through the single-stretch method and the results of previous studies employing different mechanical inputs. Differences in stiffnesses with different stretching velocities were caused by computational artifact rather than by differences in intrinsic muscular reaction. Faster rates of pre-stretch force increase prior to the stretch resulted in slightly lower stiffnesses. Different pre-stretch muscle lengths apparently did not result in different stiffnesses. The shape of the torque vs displacement curve was remarkably insensitive to the planned manipulations of the testing conditions, responding in a stereotypical manner.
Substrate stiffness regulates filopodial activities in lung cancer cells.
Yu-Ren Liou
Full Text Available Microenvironment stiffening plays a crucial role in tumorigenesis. While filopodia are generally thought to be one of the cellular mechanosensors for probing environmental stiffness, the effects of environmental stiffness on filopodial activities of cancer cells remain unclear. In this work, we investigated the filopodial activities of human lung adenocarcinoma cells CL1-5 cultured on substrates of tunable stiffness using a novel platform. The platform consists of an optical system called structured illumination nano-profilometry, which allows time-lapsed visualization of filopodial activities without fluorescence labeling. The culturing substrates were composed of polyvinyl chloride mixed with an environmentally friendly plasticizer to yield Young's modulus ranging from 20 to 60 kPa. Cell viability studies showed that the viability of cells cultured on the substrates was similar to those cultured on commonly used elastomers such as polydimethylsiloxane. Time-lapsed live cell images were acquired and the filopodial activities in response to substrates with varying degrees of stiffness were analyzed. Statistical analyses revealed that lung cancer cells cultured on softer substrates appeared to have longer filopodia, higher filopodial densities with respect to the cellular perimeter, and slower filopodial retraction rates. Nonetheless, the temporal analysis of filopodial activities revealed that whether a filopodium decides to extend or retract is purely a stochastic process without dependency on substrate stiffness. The discrepancy of the filopodial activities between lung cancer cells cultured on substrates with different degrees of stiffness vanished when the myosin II activities were inhibited by treating the cells with blebbistatin, which suggests that the filopodial activities are closely modulated by the adhesion strength of the cells. Our data quantitatively relate filopodial activities of lung cancer cells with environmental stiffness and
油膜刚度变化对转子刚度的影响%Oil Loyer Stiffness Change Affect On Rotale Stiffness
叶荣学; 孙伟
2013-01-01
In this paper,analyzed oil layer thick change affect oil layer stiffness,oil layer stiffness change affect rotate stiffness,relate stiffness change affect vibpation amplitude.%分析了油膜厚度变化对油膜刚度的影响、油膜刚度变化对转子刚度的影响、转子刚度变化对振幅的影响.
Stiffness Analysis of Corrugated Flexure Beam Used in Compliant Mechanisms
WANG Nianfeng; LIANG Xiaohe; ZHANG Xianmin
2015-01-01
Conventional flexible joints generally have limited range of motion and high stress concentration. To overcome these shortcomings, corrugated flexure beam(CF beam) is designed because of its large flexibility obtained from longer overall length on the same span. The successful design of compliant mechanisms using CF beam requires manipulation of the stiffnesses as the design variables. Empirical equations of the CF beam stiffness components, except of the torsional stiffness, are obtained by curve-fitting method. The application ranges of all the parameters in each empirical equation are also discussed. The ratio of off-axis to axial stiffness is considered as a key characteristic of an effective compliant joint. And parameter study shows that the radius of semi-circular segment and the length of straight segment contribute most to the ratio. At last, CF beam is used to design translational and rotational flexible joints, which also verifies the validity of the empirical equations. CF beam with large flexibility is presented, and empirical equations of its stiffness are proposed to facilitate the design of flexible joint with large range of motion.
Dynamic stiffness for thin-walled structures by power series
ZHU Bin; LEUNG A.Y.T.
2006-01-01
The dynamic stiffness method is introduced to analyze thin-walled structures including thin-walled straight beams and spatial twisted helix beam. A dynamic stiffness matrix is formed by using frequency dependent shape functions which are exact solutions of the governing differential equations. With the obtained thin-walled beam dynamic stiffness matrices, the thin-walled frame dynamic stiffness matrix can also be formulated by satisfying the required displacements compatibility and forces equilibrium, a method which is similar to the finite element method (FEM). Then the thin-walled structure natural frequencies can be found by equating the determinant of the system dynamic stiffness matrix to zero. By this way, just one element and several elements can exactly predict many modes of a thin-walled beam and a spatial thin-walled frame, respectively. Several cases are studied and the results are compared with the existing solutions of other methods. The natural frequencies and buckling loads of these thin-walled structures are computed.
Dynamically tuned magnetostrictive spring with electrically controlled stiffness
Scheidler, Justin J.; Asnani, Vivake M.; Dapino, Marcelo J.
2016-03-01
This paper presents the design and testing of an electrically controllable magnetostrictive spring that has a dynamically tunable stiffness (i.e., a magnetostrictive Varispring). The device enables in situ stiffness tuning or stiffness switching for vibration control applications. Using a nonlinear electromechanical transducer model and an analytical solution of linear, mechanically induced magnetic diffusion, Terfenol-D is shown to have a faster rise time to stepped voltage inputs and a significantly higher magnetic diffusion cut-off frequency relative to Galfenol. A Varispring is manufactured using a laminated Terfenol-D rod. Further rise time reductions are achieved by minimizing the rod’s diameter and winding the electromagnet with larger wire. Dynamic tuning of the Varispring’s stiffness is investigated by measuring the Terfenol-D rod’s strain response to dynamic, compressive, axial forces in the presence of sinusoidal or square wave control currents. The Varispring’s rise time is \\lt 1 ms for 1 A current switches. Continuous modulus changes up to 21.9 GPa and 500 Hz and square wave modulus changes (dynamic {{Δ }}E effect) up to 12.3 GPa and 100 Hz are observed. Stiffness tunability and tuning bandwidth can be considerably increased by operating about a more optimal bias stress and improving the control of the electrical input.
Dynamic stiffness matrix of partial-interaction composite beams
Guangjian Bao
2015-03-01
Full Text Available Composite beams have a wide application in building and bridge engineering because of their advantages of mechanical properties, constructability and economic performance. Unlike static characteristics, the methods of studying the dynamic characteristics of partial-interaction composite beams were limited, especially dynamic stiffness matrix method. In this article, the dynamic stiffness matrix of partial-interaction composite beams was derived based on the assumption of the Euler–Bernoulli beam theory, and then it was used to predict the frequencies of the free vibration of the single-span composite beams with various boundary conditions or different axial forces. The corresponding vibration modes and buckling loads were also obtained. From the comparison with the existing results, the numerical results obtained by the proposed method agreed reasonably with those in the literatures. The dynamic stiffness matrix method is an accurate method which can determine natural vibration frequencies and vibration mode shapes in any precision theoretically. As a result, when the higher precision or natural frequencies of higher order are required, the dynamic stiffness matrix method is superior when compared to other approximate and numerical methods. The dynamic stiffness matrix method can also be combined with the finite-element method to calculate the free vibration frequencies and natural mode shapes of composite beams in complex conditions.
Foundation stiffness in the linear modeling of wind turbines
Chiang, Chih-Hung; Yu, Chih-Peng; Chen, Yan-Hao; Lai, Jiunnren; Hsu, Keng-Tsang; Cheng, Chia-Chi
2017-04-01
Effects of foundation stiffness on the linear vibrations of wind turbine systems are of concerns for both planning and construction of wind turbine systems. Current study performed numerical modeling for such a problem using linear spectral finite elements. The effects of foundation stiffness were investigated for various combinations of shear wave velocity of soil, size of tower base plate, and pile length. Multiple piles are also included in the models such that the foundation stiffness can be analyzed more realistically. The results indicate that the shear wave velocity of soil and the size of tower base plate have notable effects on the dominant frequency of the turbine-tower system. The larger the lateral dimension, the stiffer the foundation. Large pile cap and multiple spaced piles result in higher stiffness than small pile cap and a mono-pile. The lateral stiffness of a mono-pile mainly depends on the shear wave velocity of soil with the exception for a very short pile that the end constraints may affect the lateral vibration of the superstructure. Effective pile length may be determined by comparing the simulation results of the frictional pile to those of the end-bearing pile.
NAFLD and Increased Aortic Stiffness: Parallel or Common Physiopathological Mechanisms?
Villela-Nogueira, Cristiane A.; Leite, Nathalie C.; Cardoso, Claudia R. L.; Salles, Gil F.
2016-01-01
Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver diseases worldwide. Liver inflammation and fibrosis related to NAFLD contribute to disease progression and increasing liver-related mortality and morbidity. Increasing data suggest that NAFLD may be linked to atherosclerotic vascular disease independent of other established cardiovascular risk factors. Central arterial stiffness has been recognized as a measure of cumulative cardiovascular risk marker load, and the measure of carotid-femoral pulse wave velocity (cf-PWV) is regarded as the gold standard assessment of aortic stiffness. It has been shown that increased aortic stiffness predicts cardiovascular morbidity and mortality in several clinical settings, including type 2 diabetes mellitus, a well-known condition associated with advanced stages of NAFLD. Furthermore, recently-published studies reported a strong association between NAFLD and increased arterial stiffness, suggesting a possible link in the pathogenesis of atherosclerosis and NAFLD. We sought to review the published data on the associations between NAFLD and aortic stiffness, in order to better understand the interplay between these two conditions and identify possible common physiopathological mechanisms. PMID:27104526
Variable stiffness sandwich panels using electrostatic interlocking core
Heath, Callum J. C.; Bond, Ian P.; Potter, Kevin D.
2016-04-01
Structural topology has a large impact on the flexural stiffness of a beam structure. Reversible attachment between discrete substructures allows for control of shear stress transfer between structural elements, thus stiffness modulation. Electrostatic adhesion has shown promise for providing a reversible latching mechanism for controllable internal connectivity. Building on previous research, a thin film copper polyimide laminate has been used to incorporate high voltage electrodes to Fibre Reinforced Polymer (FRP) sandwich structures. The level of electrostatic holding force across the electrode interface is key to the achievable level of stiffness modulation. The use of non-flat interlocking core structures can allow for a significant increase in electrode contact area for a given core geometry, thus a greater electrostatic holding force. Interlocking core geometries based on cosine waves can be Computer Numerical Control (CNC) machined from Rohacell IGF 110 Foam core. These Interlocking Core structures could allow for enhanced variable stiffness functionality compared to basic planar electrodes. This novel concept could open up potential new applications for electrostatically induced variable stiffness structures.
Crosstalk between oxidative and nitrosative stress and arterial stiffness.
Mozos, Ioana; Luca, Constantin Tudor
2017-02-01
Arterial stiffness, the expression of reduced arterial elasticity, is an effective predictor of cardiovascular disorders. Oxidative stress is an imbalance between exposure to toxic reactive oxygen species (ROS) and antioxidant systems. The increase in reactive nitrogen species (RNS) is termed nitrosative stress. We review the main mechanisms and products linking arterial stiffness with oxidative and nitrosative stress in several disorders, focusing on recent experimental and clinical data, and the mechanisms explaining benefits of antioxidant therapy. Oxidative and nitrosative stress play important roles in arterial stiffness elevation in several disorders, including diabetes mellitus, hypertension, metabolic syndrome, obesity, peripheral arterial disease, chronic obstructive pulmonary disease, systemic lupus erythematosus, thalassemia, Kawasaki disease and malignant disorders. Oxidative and nitrosative stress are responsible for endothelial dysfunction due to uncoupling of the nitric oxide synthase, oxidative damage to lipids, proteins and DNA in vascular endothelial cells, associated with inflammation, arteriosclerosis and atherosclerosis. Regular physical exercise, caloric restriction, red wine, statins, sartans, metformin, oestradiol, curcumin and combinations of antioxidant vitamins are therapeutic strategies that may decrease arterial stiffness and oxidative stress thus reducing the risk of cardiovascular events. ROS and RNS represent potential therapeutic targets for preventing progression of arterial stiffness.
Mechanical Genomics Identifies Diverse Modulators of Bacterial Cell Stiffness.
Auer, George K; Lee, Timothy K; Rajendram, Manohary; Cesar, Spencer; Miguel, Amanda; Huang, Kerwyn Casey; Weibel, Douglas B
2016-06-22
Bacteria must maintain mechanical integrity to withstand the large osmotic pressure differential across the cell membrane and wall. Although maintaining mechanical integrity is critical for proper cellular function, a fact exploited by prominent cell-wall-targeting antibiotics, the proteins that contribute to cellular mechanics remain unidentified. Here, we describe a high-throughput optical method for quantifying cell stiffness and apply this technique to a genome-wide collection of ∼4,000 Escherichia coli mutants. We identify genes with roles in diverse functional processes spanning cell-wall synthesis, energy production, and DNA replication and repair that significantly change cell stiffness when deleted. We observe that proteins with biochemically redundant roles in cell-wall synthesis exhibit different stiffness defects when deleted. Correlating our data with chemical screens reveals that reducing membrane potential generally increases cell stiffness. In total, our work demonstrates that bacterial cell stiffness is a property of both the cell wall and broader cell physiology and lays the groundwork for future systematic studies of mechanoregulation.
Casimir torque in weak coupling
Milton, Kimball A; Long, William
2013-01-01
In this paper, dedicated to Johan H{\\o}ye on the occasion of his 70th birthday, we examine manifestations of Casimir torque in the weak-coupling approximation, which allows exact calculations so that comparison with the universally applicable, but generally uncontrolled, proximity force approximation may be made. In particular, we examine Casimir energies between planar objects characterized by $\\delta$-function potentials, and consider the torque that arises when angles between the objects are changed. The results agree very well with the proximity force approximation when the separation distance between the objects is small compared with their sizes. In the opposite limit, where the size of one object is comparable to the separation distance, the shape dependence starts becoming irrelevant. These calculations are illustrative of what to expect for the torques between, for example, conducting planar objects, which eventually should be amenable to both improved theoretical calculation and experimental verific...
WANG Baocang; LIU Shuanggen; HU Yupu
2006-01-01
The security of the RSA system with the prime pairs of some special form is investigated. A new special-purpose algorithm for factoring RSA numbers is proposed. The basic idea of the method is to factor RSA numbers by factoring a well-chosen quadratic polynomial with integral coefficients. When viewed as a general-purpose algorithm, the new algorithm has a high computational complexity. It is shown that the RSA number n=pq can be easily factored if p and q have the special form of p=as+b, q=cs+d, where a, b, c, d are relatively small numbers. Such prime pairs (p, q) are the weak keys of RSA, so when we generate RSA modulus, we should avoid using such prime pairs (p, q).
Albracht, Kirsten; Arampatzis, Adamantios
2013-06-01
The purpose of the present study was to investigate whether increased tendon-aponeurosis stiffness and contractile strength of the triceps surae (TS) muscle-tendon units induced by resistance training would affect running economy. Therefore, an exercise group (EG, n = 13) performed a 14-week exercise program, while the control group (CG, n = 13) did not change their training. Maximum isometric voluntary contractile strength and TS tendon-aponeurosis stiffness, running kinematics and fascicle length of the gastrocnemius medialis (GM) muscle during running were analyzed. Furthermore, running economy was determined by measuring the rate of oxygen consumption at two running velocities (3.0, 3.5 ms(-1)). The intervention resulted in a ∼7 % increase in maximum plantarflexion muscle strength and a ∼16 % increase in TS tendon-aponeurosis stiffness. The EG showed a significant ∼4 % reduction in the rate of oxygen consumption and energy cost, indicating a significant increase in running economy, while the CG showed no changes. Neither kinematics nor fascicle length and elongation of the series-elastic element (SEE) during running were affected by the intervention. The unaffected SEE elongation of the GM during the stance phase of running, in spite of a higher tendon-aponeurosis stiffness, is indicative of greater energy storage and return and a redistribution of muscular output within the lower extremities while running after the intervention, which might explain the improved running economy.
Effect of sliding friction on the dynamics of spur gear pair with realistic time-varying stiffness
He, Song; Gunda, Rajendra; Singh, Rajendra
2007-04-01
The chief objective of this article is to propose a new method of incorporating the sliding friction and realistic time-varying stiffness into an analytical (multi-degree-of-freedom) spur gear model and to evaluate their effects. An accurate finite element/contact mechanics analysis code is employed, in the "static" mode, to compute the mesh stiffness at every time instant under a range of loading conditions. Here, the time-varying stiffness is calculated as an effective function which may also include the effect of profile modifications. The realistic mesh stiffness is then incorporated into the linear time-varying spur gear model with the contributions of sliding friction. Proposed methods are illustrated via two spur gear examples and validated by using the finite element in the "dynamic" mode as experimental results. A key question whether the sliding friction is indeed the source of the off-line-of-action forces and motions is then answered by our analytical model. Finally, the effect of the profile modification on the dynamic transmission error has been analytically examined under the influence of sliding friction. For instance, the linear tip relief introduces an amplification in the off-line-of-action forces and motions due to an out of phase relationship between the normal load and friction forces.
Shi, Pujiang; Laude, Augustinus; Yeong, Wai Yee
2017-04-01
In this article, mouse fibroblast cells (L929) were seeded on 2%, 5%, and 10% alginate hydrogels, and they were also bio-printed with 2%, 5%, and 10% alginate solutions individually to form constructs. The elastic and viscous moduli of alginate solutions, their interior structure and stiffness, interactions of cells and alginate, cell viability, migration and morphology were investigated by rheometer, MTT assay, scanning electron microscope (SEM), and fluorescent microscopy. The three types of bio-printed scaffolds of distinctive stiffness were prepared, and the seeded cells showed robust viability either on the alginate hydrogel surfaces or in the 3D bio-printed constructs. Majority of the proliferated cells in the 3D bio-printed constructs weakly attached to the surrounding alginate matrix. The concentration of alginate solution and hydrogel stiffness influenced cell migration and morphology, moreover the cells formed spheroids in the bio-printed 10% alginate hydrogel construct. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1009-1018, 2017.
Output-Based Control of Robots with Variable Stiffness Actuation
Gianluca Palli
2011-01-01
Full Text Available The output-based control of a redundant robotic manipulator with relevant and adjustable joint stiffness is addressed. The proposed controller is configured as a cascade system that allows the decoupling of the actuators dynamics from the arm dynamics and the consequent reduction of the order of the manipulator dynamic model. Moreover, the proposed controller does not require the knowledge of the whole robot state: only the positions of the actuators and of the joints are necessary. This approach represents a significant simplification with respect to previously proposed state feedback techniques. The problem of controlling simultaneously the position trajectory and the desired stiffness in both the joint and work space is investigated, and the relations between the manipulator redundancy and the selection of both the joint and work space stiffness of the manipulator are discussed. The effectiveness of the proposed approach is verified by simulations of a 3 degrees of freedom planar manipulator.
Associations between bicycling and carotid arterial stiffness in adolescents
Ried-Larsen, M; Grøntved, A; Østergaard, Lars;
2015-01-01
The aim of the study was to investigate the associations between bicycling and carotid arterial stiffness, independent of objectively measured moderate-and-vigorous physical activity. This cross-sectional study included 375 adolescents (age 15.7 ± 0.4 years) from the Danish site of the European...... Youth Heart Study. Total frequency of bicycle usage was assessed by self-report, and carotid arterial stiffness was assessed using B-mode ultrasound. After adjusting for pubertal status, body height, and objectively measured physical activity and other personal lifestyle and demographic factors, boys...... modulus [standard beta -0.48 (95% CI -0.91 to -0.06)]. Similar trends were observed when investigating the association between commuter bicycling and carotid arterial stiffness. These associations were not observed in girls. Our observations suggest that increasing bicycling in adolescence may...
Semiactive variable stiffness control for parametric vibration of cables
Li Hui; Chen Wenli; Ou Jinping
2006-01-01
In this paper, a semiactive variable stiffness (SVS) device is used to decrease cable oscillations caused by parametric excitation, and the equation of motion of the parametric vibration of the cable with this SVS device is presented.The ON/OFF control algorithm is used to operate the SVS control device. The vibration response of the cable with the SVS device is numerically studied for a variety of additional stiffness combinations in both the frequency and time domains and for both parametric and classical resonance vibration conditions. The numerical studies further consider the cable sag effect.From the numerical results, it is shown that the SVS device effectively suppresses the cable resonance vibration response, and as the stiffness of the device increases, the device achieves greater suppression of vibration. Moreover, it was shown that the SVS device increases the critical axial displacement of the excitation under cable parametric vibration conditions.
Micromechanical analysis of the behavior of stiff clay
Zhen-Yu Yin; Ching S. Chang; Pierre-Yves Hicher; Jian-Hua Wang
2011-01-01
Cementations formed in geological timescale are observed in various stiff clays.A micromechanical stress strain model is developed for modeling the effect of cementation on the deformation behavior of stiff clay.The proposed approach considers explicitly cementations at intercluster contacts,which is different from conventional model.The concept of inter-cluster bonding is introduced to account for an additional cohesion in shear sliding and a higher yield stress in normal compression.A damage law for inter-cluster bonding is proposed at cluster contacts for the debonding process during mechanical loading.The model is used to simulate numerous stress-path tests on Vallericca stiff clay.The applicability of the present model is evaluated through comparisons between the predicted and the measured results.In order to explain the stress-induced anisotropy arising from extemally applied load,the evolution of local stresses and local strains at inter-cluster planes are discussed.
Enhanced stiffness modeling of manipulators with passive joints
Pashkevich, Anatoly; Chablat, Damien
2011-01-01
The paper presents a methodology to enhance the stiffness analysis of serial and parallel manipulators with passive joints. It directly takes into account the loading influence on the manipulator configuration and, consequently, on its Jacobians and Hessians. The main contributions of this paper are the introduction of a non-linear stiffness model for the manipulators with passive joints, a relevant numerical technique for its linearization and computing of the Cartesian stiffness matrix which allows rank-deficiency. Within the developed technique, the manipulator elements are presented as pseudo-rigid bodies separated by multidimensional virtual springs and perfect passive joints. Simulation examples are presented that deal with parallel manipulators of the Ortholide family and demonstrate the ability of the developed methodology to describe non-linear behavior of the manipulator structure such as a sudden change of the elastic instability properties (buckling).
Mixed, Nonsplit, Extended Stability, Stiff Integration of Reaction Diffusion Equations
Alzahrani, Hasnaa H.
2016-07-26
A tailored integration scheme is developed to treat stiff reaction-diffusion prob- lems. The construction adapts a stiff solver, namely VODE, to treat reaction im- plicitly together with explicit treatment of diffusion. The second-order Runge-Kutta- Chebyshev (RKC) scheme is adjusted to integrate diffusion. Spatial operator is de- scretised by second-order finite differences on a uniform grid. The overall solution is advanced over S fractional stiff integrations, where S corresponds to the number of RKC stages. The behavior of the scheme is analyzed by applying it to three simple problems. The results show that it achieves second-order accuracy, thus, preserving the formal accuracy of the original RKC. The presented development sets the stage for future extensions, particularly, to multidimensional reacting flows with detailed chemistry.
Design and Construction of a Spring Stiffness Testing Machine
Olugboji Oluwafemi Ayodeji
2015-04-01
Full Text Available A spring stiffness testing machine was produced which differentiates a good spring from bad one using hydraulic principle and locally sourced materials were used to produce at relative low cost and high efficiency. It also categories each spring by stiffness into one of several distinct categories based on its performance under test. This is to ensure that in the final assembly process, springs with similar performance characteristics are mated to ensure a better ride, more précised handling and improved overall vehicle or equipment performance. The construction of the machine involves basically the fabrication process which includes such operation as cutting, benching, welding, grinding, drilling, machining, casting and screw fastening. Taken into consideration under test, were types of compression springs with varying spring loading and their different displacement recorded at different pressures to compare their stiffness.
Estimation of Stiffness Parameter on the Common Carotid Artery
Koya, Yoshiharu; Mizoshiri, Isao; Matsui, Kiyoaki; Nakamura, Takashi
The arteriosclerosis is on the increase with an aging or change of our living environment. For that reason, diagnosis of the common carotid artery using echocardiogram is doing to take precautions carebropathy. Up to the present, several methods to measure stiffness parameter of the carotid artery have been proposed. However, they have analyzed at the only one point of common carotid artery. In this paper, we propose the method of analysis extended over a wide area of common carotid artery. In order to measure stiffness parameter of common carotid artery from echocardiogram, it is required to detect two border curves which are boundaries between vessel wall and blood. The method is composed of two steps. The first step is the detection of border curves, and the second step is the calculation of stiffness parameter using diameter of common carotid artery. Experimental results show the validity of the proposed method.
Morphological Computation of Haptic Perception of a Controllable Stiffness Probe.
Nantachai Sornkarn
Full Text Available When people are asked to palpate a novel soft object to discern its physical properties such as texture, elasticity, and even non-homogeneity, they not only regulate probing behaviors, but also the co-contraction level of antagonistic muscles to control the mechanical impedance of fingers. It is suspected that such behavior tries to enhance haptic perception by regulating the function of mechanoreceptors at different depths of the fingertips and proprioceptive sensors such as tendon and spindle sensors located in muscles. In this paper, we designed and fabricated a novel two-degree of freedom variable stiffness indentation probe to investigate whether the regulation of internal stiffness, indentation, and probe sweeping velocity (PSV variables affect the accuracy of the depth estimation of stiff inclusions in an artificial silicon phantom using information gain metrics. Our experimental results provide new insights into not only the biological phenomena of haptic perception but also new opportunities to design and control soft robotic probes.
Design of Stiffness for Air Spring Based on ABAQUS
Hongguang Li
2013-01-01
Full Text Available In this paper, an axisymmetric finite element (FE model of an air spring was carried out with the software ABAQUS to design its target vertical stiffness. The bellows was simulated by the reinforced surface element. The compressed gas in the cavity of the air spring was represented by the hydrostatic fluid element. The target stiffness is obtained by modifying the valid area of the cross section. At last, the results of experiment coincided well with the simulation data. The study shows that the static stiffness of air spring is sensitive to the effective area of the cross section. The conclusion has certain practical significance for the design and the optimization of the same kind of air spring.
Stiffness control of magnetorheological gels for adaptive tunable vibration absorber
Kim, Hyun Kee; Kim, Hye Shin; Kim, Young-Keun
2017-01-01
In this study, a stiffness feedback control system for magnetorheological (MR) gel—a smart material of variable stiffness—is proposed, toward the design of a tunable vibration absorber that can adaptively tune to a time varying disturbance in real time. A PID controller was designed to track the required stiffness of the MR gel by controlling the magnitude of the target external magnetic field pervading the MR gel. This paper proposes a novel magnetic field generator that could produce a variable magnetic field with low energy consumption. The performance of the MR gel stiffness control was validated through experiments that showed the MR gel absorber system could be automatically tuned from 56 Hz to 67 Hz under a field of 100 mT to minimize the vibration of the primary system.
Effective Stiffness: Generalizing Effective Resistance Sampling to Finite Element Matrices
Avron, Haim
2011-01-01
We define the notion of effective stiffness and show that it can used to build sparsifiers, algorithms that sparsify linear systems arising from finite-element discretizations of PDEs. In particular, we show that sampling $O(n\\log n)$ elements according to probabilities derived from effective stiffnesses yields an high quality preconditioner that can be used to solve the linear system in a small number of iterations. Effective stiffness generalizes the notion of effective resistance, a key ingredient of recent progress in developing nearly linear symmetric diagonally dominant (SDD) linear solvers. Solving finite elements problems is of considerably more interest than the solution of SDD linear systems, since the finite element method is frequently used to numerically solve PDEs arising in scientific and engineering applications. Unlike SDD systems, which are relatively easy to precondition, there has been limited success in designing fast solvers for finite element systems, and previous algorithms usually tar...
Mahanta, J.; P. K. Das
2012-01-01
A new class of fuzzy closed sets, namely fuzzy weakly closed set in a fuzzy topological space is introduced and it is established that this class of fuzzy closed sets lies between fuzzy closed sets and fuzzy generalized closed sets. Alongwith the study of fundamental results of such closed sets, we define and characterize fuzzy weakly compact space and fuzzy weakly closed space.
Twisting theory for weak Hopf algebras
CHEN Ju-zhen; ZHANG Yan; WANG Shuan-hong
2008-01-01
The main aim of this paper is to study the twisting theory of weak Hopf algebras and give an equivalence between the (braided) monoidal categories of weak Hopf bimodules over the original and the twisted weak Hopf algebra to generalize the result from Oeckl (2000).
Reconstruction of weak quasi-Hopf algebras
Häring, Reto Andreas
1995-01-01
All rational semisimple braided tensor categories are representation categories of weak quasi Hopf algebras. To proof this result we construct for any given category of this kind a weak quasi tensor functor to the category of finite dimensional vector spaces. This allows to reconstruct a weak quasi Hopf algebra with the given category as its representation category.
Colloquium: Understanding quantum weak values: Basics and applications
Dressel, Justin; Malik, Mehul; Miatto, Filippo M.; Jordan, Andrew N.; Boyd, Robert W.
2014-01-01
Since its introduction 25 years ago, the quantum weak value has gradually transitioned from a theoretical curiosity to a practical laboratory tool. While its utility is apparent in the recent explosion of weak value experiments, its interpretation has historically been a subject of confusion. Here a pragmatic introduction to the weak value in terms of measurable quantities is presented, along with an explanation for how it can be determined in the laboratory. Further, its application to three distinct experimental techniques is reviewed. First, as a large interaction parameter it can amplify small signals above technical background noise. Second, as a measurable complex value it enables novel techniques for direct quantum state and geometric phase determination. Third, as a conditioned average of generalized observable eigenvalues it provides a measurable window into nonclassical features of quantum mechanics. In this selective review, a single experimental configuration to discuss and clarify each of these applications is used.
Modifiable risk factors for increased arterial stiffness in outpatient nephrology.
Usama Elewa
Full Text Available Arterial stiffness, as measured by pulse wave velocity (PWV, is an independent predictor of cardiovascular events and mortality. Arterial stiffness increases with age. However, modifiable risk factors such as smoking, BP and salt intake also impact on PWV. The finding of modifiable risk factors may lead to the identification of treatable factors, and, thus, is of interest to practicing nephrologist. We have now studied the prevalence and correlates of arterial stiffness, assessed by PWV, in 191 patients from nephrology outpatient clinics in order to identify modifiable risk factors for arterial stiffness that may in the future guide therapeutic decision-making. PWV was above normal levels for age in 85/191 (44.5% patients. Multivariate analysis showed that advanced age, systolic BP, diabetes mellitus, serum uric acid and calcium polystyrene sulfonate therapy or calcium-containing medication were independent predictors of PWV. A new parameter, Delta above upper limit of normal PWV (Delta PWV was defined to decrease the weight of age on PWV values. Delta PWV was calculated as (measured PWV - (upper limit of the age-adjusted PWV values for the general population. Mean±SD Delta PWV was 0.76±1.60 m/sec. In multivariate analysis, systolic blood pressure, active smoking and calcium polystyrene sulfonate therapy remained independent predictors of higher delta PWV, while age, urinary potassium and beta blocker therapy were independent predictors of lower delta PWV. In conclusion, arterial stiffness was frequent in nephrology outpatients. Systolic blood pressure, smoking, serum uric acid, calcium-containing medications, potassium metabolism and non-use of beta blockers are modifiable factors associated with increased arterial stiffness in Nephrology outpatients.
Modifiable risk factors for increased arterial stiffness in outpatient nephrology.
Elewa, Usama; Fernandez-Fernandez, Beatriz; Alegre, Raquel; Sanchez-Niño, Maria D; Mahillo-Fernández, Ignacio; Perez-Gomez, Maria Vanessa; El-Fishawy, Hussein; Belal, Dawlat; Ortiz, Alberto
2015-01-01
Arterial stiffness, as measured by pulse wave velocity (PWV), is an independent predictor of cardiovascular events and mortality. Arterial stiffness increases with age. However, modifiable risk factors such as smoking, BP and salt intake also impact on PWV. The finding of modifiable risk factors may lead to the identification of treatable factors, and, thus, is of interest to practicing nephrologist. We have now studied the prevalence and correlates of arterial stiffness, assessed by PWV, in 191 patients from nephrology outpatient clinics in order to identify modifiable risk factors for arterial stiffness that may in the future guide therapeutic decision-making. PWV was above normal levels for age in 85/191 (44.5%) patients. Multivariate analysis showed that advanced age, systolic BP, diabetes mellitus, serum uric acid and calcium polystyrene sulfonate therapy or calcium-containing medication were independent predictors of PWV. A new parameter, Delta above upper limit of normal PWV (Delta PWV) was defined to decrease the weight of age on PWV values. Delta PWV was calculated as (measured PWV) - (upper limit of the age-adjusted PWV values for the general population). Mean±SD Delta PWV was 0.76±1.60 m/sec. In multivariate analysis, systolic blood pressure, active smoking and calcium polystyrene sulfonate therapy remained independent predictors of higher delta PWV, while age, urinary potassium and beta blocker therapy were independent predictors of lower delta PWV. In conclusion, arterial stiffness was frequent in nephrology outpatients. Systolic blood pressure, smoking, serum uric acid, calcium-containing medications, potassium metabolism and non-use of beta blockers are modifiable factors associated with increased arterial stiffness in Nephrology outpatients.
[Stiff baby syndrome is a rare cause of neonatal hypertonicity].
Rønne, Maria Sode; Nielsen, Preben Berg; Mogensen, Christian Backer
2014-02-24
Stiff baby syndrome (hyperekplexia) is a rare genetic disorder. The condition can easily be misdiagnosed as epilepsy or severe sepsis because of hypertonicity and seizure-like episodes and has an increased risk of severe apnoea and sudden infant death. Tapping of the nasal bridge inducing a startle response is the clinical hallmark. We report cases of two sisters born with stiff baby syndrome with hypertonicity, exaggerated startle reaction and cyanosis. The syndrome has a good prognosis if treated with clonazepam and both cases were developmental normal after one year.
Diagnosis and clinical assessment of a stiff shoulder.
Armstrong, Alison
2015-04-01
The assessment of a stiff shoulder is explored, the necessary investigations to reach a diagnosis are discussed, and the likely causes that can contribute to a frozen shoulder are described. Two flow diagrams are included to help in reaching a conclusion when seeing a patient with a stiff shoulder. The key elements to reaching that conclusion are: carefully listening to the patients story, noting whether there has been a history of trauma, as well as a careful and thorough examination and a plain X-ray with two views.
Fast Stiffness Matrix Calculation for Nonlinear Finite Element Method
Emir Gülümser
2014-01-01
Full Text Available We propose a fast stiffness matrix calculation technique for nonlinear finite element method (FEM. Nonlinear stiffness matrices are constructed using Green-Lagrange strains, which are derived from infinitesimal strains by adding the nonlinear terms discarded from small deformations. We implemented a linear and a nonlinear finite element method with the same material properties to examine the differences between them. We verified our nonlinear formulation with different applications and achieved considerable speedups in solving the system of equations using our nonlinear FEM compared to a state-of-the-art nonlinear FEM.
Beam section stiffness properties usig 3D finite elements
Couturier, Philippe; Krenk, Steen; Høgsberg, Jan Becker
2013-01-01
The cross-section properties of a beam is characterized by a six by six stiffness matrix, relating the six generalized strains to the conjugate section forces. The problem is formulated as a single-layer finite element model of a slice of the beam, on which the six deformation modes are imposed via...... Lagrange multipliers. The Lagrange multipliers represent the constraining forces, and thus combine to form the cross-section stiffness matrix. The theory is illustrated by a simple isotropic cross-section....
Simplified formula for isoparametric quadrilateral element stiffness matrix
Changlian, X.
1987-02-01
Homogeneous parallelogram and quasi-parallelogram elements are usually used in finite element seismic modeling. Theoretically, the coordinates of element nodes may be arbitrary values on condition that elements are successive and not superposed. Isoparametric quadrilateral elements, whose nodes are presumed to be in laterally uniform distribution, are used so that not only unit stiffness matrix formula is essentially simplified to cut computing time but also finite element method remains flexible enough to be used in complex modeling. Simplified formulae for computing the stiffness matrices in four cases are derived, which, compared with corresponding Gauss integration algorithm, can cut 94-98% computing time.
Weight reduction and aortic stiffness in obese children and adolescents
Hvidt, K. N.; Olsen, M. H.; Ibsen, H.
2015-01-01
Little is known about the effect of weight reduction on aortic stiffness and especially so in the young. The present study investigates whether weight reduction influences aortic stiffness in obese children and adolescents. Carotid-femoral pulse wave velocity (cfPWV) and augmentation index at heart...... rate 75 (AIx@HR75) were measured in 72 obese patients aged 10-18 years at baseline and after 1-year of lifestyle intervention (follow-up). We found that although the degree of obesity decreased (Delta body mass index z-score: -0.24 +/- 0.45, P ....27 +/- 0.47 ms(-1), P obesity measures. No significant change...
An asymptotic approach to the adhesion of thin stiff films
Dumont, Serge; Rizzoni, Raffaella
2013-01-01
In this paper, the asymptotic first order analysis, both mathematical and numerical, of two structures bonded together is presented. Two cases are considered, the gluing of an elastic structure with a rigid body and the gluing of two elastic structures. The glue is supposed to be elastic and to have its stiffness of the same order than those of the elastic structures. An original numerical method is developed to solve the mechanical problem of stiff interface at order 1, based on the Nitsche's method. Several numerical examples are provided to show the efficiency of both the analytical approximation and the numerical method.
Experimental measurement of the stiffness of the cupula.
Grant, J W; Van Buskirk, W C
1976-06-01
An experimental procedure is described which consists of cutting the canal duct, inserting a micropipette and administering known volumetric displacements to the cupula. The cupula is made visible by dying the endolymph. Known displacements are administered to the cupula, and the time constant of the return to its equilibrium position is measured. With this information, the stiffness of the cupula is calculated. The experiment was successfully carried out on five White King pigeons. The mean stiffness found in somewhat less than other results reported in the literature, and reasons for this discrepancy are noted.
A Weak Quantum Blind Signature with Entanglement Permutation
Lou, Xiaoping; Chen, Zhigang; Guo, Ying
2015-09-01
Motivated by the permutation encryption algorithm, a weak quantum blind signature (QBS) scheme is proposed. It involves three participants, including the sender Alice, the signatory Bob and the trusted entity Charlie, in four phases, i.e., initializing phase, blinding phase, signing phase and verifying phase. In a small-scale quantum computation network, Alice blinds the message based on a quantum entanglement permutation encryption algorithm that embraces the chaotic position string. Bob signs the blinded message with private parameters shared beforehand while Charlie verifies the signature's validity and recovers the original message. Analysis shows that the proposed scheme achieves the secure blindness for the signer and traceability for the message owner with the aid of the authentic arbitrator who plays a crucial role when a dispute arises. In addition, the signature can neither be forged nor disavowed by the malicious attackers. It has a wide application to E-voting and E-payment system, etc.
Weakly Distributive Modules. Applications to Supplement Submodules
Engin Büyükaşik; Yilmaz M Demirci
2010-11-01
In this paper, we define and study weakly distributive modules as a proper generalization of distributive modules. We prove that, weakly distributive supplemented modules are amply supplemented. In a weakly distributive supplemented module every submodule has a unique coclosure. This generalizes a result of Ganesan and Vanaja. We prove that -projective duo modules, in particular commutative rings, are weakly distributive. Using this result we obtain that in a commutative ring supplements are unique. This generalizes a result of Camillo and Lima. We also prove that any weakly distributive $\\oplus$-supplemented module is quasi-discrete.
Weakly relativistic dispersion of Bernstein waves
Robinson, P. A.
1988-01-01
Weakly relativistic effects on the dispersion of Bernstein waves are investigated for waves propagating nearly perpendicular to a uniform magnetic field in a Maxwellian plasma. Attention is focused on those large-wave-vector branches that are either weakly damped or join continuously onto weakly damped branches since these are the modes of most interest in applications. The transition between dispersion at perpendicular and oblique propagation is examined and major weakly relativistic effects can dominate even in low-temperature plasmas. A number of simple analytic criteria are obtained which delimit the ranges of harmonic number and propagation angle within which various types of weakly damped Bernstein modes can exist.
Weakly relativistic dispersion of Bernstein waves
Robinson, P. A.
1988-01-01
Weakly relativistic effects on the dispersion of Bernstein waves are investigated for waves propagating nearly perpendicular to a uniform magnetic field in a Maxwellian plasma. Attention is focused on those large-wave-vector branches that are either weakly damped or join continuously onto weakly damped branches since these are the modes of most interest in applications. The transition between dispersion at perpendicular and oblique propagation is examined and major weakly relativistic effects can dominate even in low-temperature plasmas. A number of simple analytic criteria are obtained which delimit the ranges of harmonic number and propagation angle within which various types of weakly damped Bernstein modes can exist.