WorldWideScience

Sample records for warrant closer scrutiny

  1. Closer Scrutiny.

    Science.gov (United States)

    Kennedy, Mike

    2001-01-01

    Examines strategies that some universities are using to make their stadium sporting events more secure in the post September 11 era. Schools reveal how they are minimizing their terrorism risks and providing a greater security presence. (GR)

  2. Questioning scrutiny: bioethics, sexuality, and gender identity.

    Science.gov (United States)

    Wahlert, Lance; Fiester, Autumn

    2012-09-01

    The clinic is a loaded space for LGBTQI persons. Historically a site of pathology and culturally a site of stigma, the contemporary clinic for queer patient populations and their loved ones is an ethically fraught space. This paper, which introduces the featured articles of this special issue of the Journal of Bioethical Inquiry on "Bioethics, Sexuality, and Gender Identity," begins by offering an analysis of scrutiny itself. How do we scrutinize? When is it apt for us to scrutinize? And what are the benefits and perils of clinical and bioethical scrutiny? Bearing in mind these questions, the second half of this paper introduces the feature articles in this special issue in response to such forms of scrutiny. How, why, when, and in what ways to sensitively scrutinize LGBTQI persons in the clinic are the aims of this piece.

  3. Database Security and the Problem of Polyinstantiation: a moral scrutiny

    Directory of Open Access Journals (Sweden)

    Mikko Siponen

    2002-11-01

    Full Text Available In the area of computer security the problem of polyinstantiation is widely recognized. The research on polyinstantiation can be considered morally questionable, since it involves lying. This being the case, a moral scrutiny on the problem of polyinstantiation is warranted. The morality of polyinstantiation shall be critically analysed from the viewpoint of a moral philosophical framework. The moral philosophical framework used includes 1 Kantian ethics, 2 the universality theses advocated by Hare, Rawls, Gewirth, Jewish-Christian ethics, and Confucian ethics, 3 utilitarianism, and 4 Theory of Information Ethics (IE by Floridi. The result of this analysis suggests that research and practice on polyinstantiation is morally questionable, at least in the light of the chosen moral philosophical theories. The aim of the paper is not, however, to deem polyinstantiation as morally wrong altogether, but to provide researchers and practitioners with tools and insights for analyzing the morality of polyinstantiation in different cases. Moreover, the results suggest that, as far as polyinstantiation is concerned, traditional ethics theories seem to be at least as adequate as IE.

  4. Trading Platform for the Global Warrant Markets

    Directory of Open Access Journals (Sweden)

    Iosif ZIMAN

    2011-01-01

    Full Text Available Global warrant markets are among the most active financial markets in the retail derivatives investment landscape currently. In this context some of the most relevant markets in the last years have been the ones across Asia and in particular Hong Kong, Korea and Japan. This paper introduces the financial instruments used in connection with the warrant markets, pre-sents and offers suggestions for setting up a generic warrant market making system and in-troduces the main concepts and components that need to be taken into account when develop-ing these systems targeting an exchange driven or E-Businesscontext.

  5. Spot on for liars! How public scrutiny influences ethical behavior.

    Science.gov (United States)

    Ostermaier, Andreas; Uhl, Matthias

    2017-01-01

    We examine whether people are more honest in public than in private. In a laboratory experiment, we have subjects roll dice and report outcomes either in public or in private. Higher reports yield more money and lies cannot be detected. We also elicit subjects' ethical mindsets and their expectations about others' reports. We find that outcome-minded subjects lie less in public to conform with their expectations about others' reports. Ironically, these expectations are false. Rule-minded subjects, in turn, do not respond to public scrutiny. These findings challenge the common faith in public scrutiny to promote ethical behavior. While public scrutiny eventually increases honesty, this effect is contingent on people's mindsets and expectations.

  6. Spot on for liars! How public scrutiny influences ethical behavior.

    Directory of Open Access Journals (Sweden)

    Andreas Ostermaier

    Full Text Available We examine whether people are more honest in public than in private. In a laboratory experiment, we have subjects roll dice and report outcomes either in public or in private. Higher reports yield more money and lies cannot be detected. We also elicit subjects' ethical mindsets and their expectations about others' reports. We find that outcome-minded subjects lie less in public to conform with their expectations about others' reports. Ironically, these expectations are false. Rule-minded subjects, in turn, do not respond to public scrutiny. These findings challenge the common faith in public scrutiny to promote ethical behavior. While public scrutiny eventually increases honesty, this effect is contingent on people's mindsets and expectations.

  7. Transparency Under Scrutiny: Information Disclosure in Global Environmental Governance.

    NARCIS (Netherlands)

    Gupta, A.

    2008-01-01

    Although transparency is a key concept of our times, it remains a relatively understudied phenomenon in global environmental politics. The link between transparency and accountable, legitimate and effective governance is assumed, yet the nature and workings of this link require further scrutiny.

  8. Particulate Matter: a closer look

    NARCIS (Netherlands)

    Buijsman E; Beck JP; Bree L van; Cassee FR; Koelemeijer RBA; Matthijsen J; Thomas R; Wieringa K; LED; MGO

    2005-01-01

    The summary in booklet form 'Fijn stof nader bekeken' (Particulate Matter: a closer look) , published in Dutch by the Netherlands Environmental Assessment Agency (MNP) and the Environment and Safety Division of the National Institute for Public Health and the Environment (RIVM), has been designed to

  9. The N2HDM under theoretical and experimental scrutiny

    Energy Technology Data Exchange (ETDEWEB)

    Mühlleitner, Margarete [Institute for Theoretical Physics, Karlsruhe Institute of Technology, 76128 Karlsruhe (Germany); Sampaio, Marco O.P. [Departamento de Física, Universidade de Aveiro and CIDMA, Campus de Santiago, 3810-183 Aveiro (Portugal); Santos, Rui [ISEL - Instituto Superior de Engenharia de Lisboa, Instituto Politécnico de Lisboa, 1959-007 Lisboa (Portugal); Centro de Física Teórica e Computacional, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, Edifício C8, 1749-016 Lisboa (Portugal); Wittbrodt, Jonas [Institute for Theoretical Physics, Karlsruhe Institute of Technology, 76128 Karlsruhe (Germany); Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, D-22607 Hamburg (Germany)

    2017-03-17

    The N2HDM is based on the CP-conserving 2HDM extended by a real scalar singlet field. Its enlarged parameter space and its fewer symmetry conditions as compared to supersymmetric models allow for an interesting phenomenology compatible with current experimental constraints, while adding to the 2HDM sector the possibility of Higgs-to-Higgs decays with three different Higgs bosons. In this paper the N2HDM is subjected to detailed scrutiny. Regarding the theoretical constraints we implement tests of tree-level perturbativity and vacuum stability. Moreover, we present, for the first time, a thorough analysis of the global minimum of the N2HDM. The model and the theoretical constraints have been implemented in ScannerS, and we provide N2HDECAY, a code based on HDECAY, for the computation of the N2HDM branching ratios and total widths including the state-of-the-art higher order QCD corrections and off-shell decays. We then perform an extensive parameter scan in the N2HDM parameter space, with all theoretical and experimental constraints applied, and analyse its allowed regions. We find that large singlet admixtures are still compatible with the Higgs data and investigate which observables will allow to restrict the singlet nature most effectively in the next runs of the LHC. Similarly to the 2HDM, the N2HDM exhibits a wrong-sign parameter regime, which will be constrained by future Higgs precision measurements.

  10. The N2HDM under theoretical and experimental scrutiny

    International Nuclear Information System (INIS)

    Mühlleitner, Margarete; Sampaio, Marco O.P.; Santos, Rui; Wittbrodt, Jonas

    2017-01-01

    The N2HDM is based on the CP-conserving 2HDM extended by a real scalar singlet field. Its enlarged parameter space and its fewer symmetry conditions as compared to supersymmetric models allow for an interesting phenomenology compatible with current experimental constraints, while adding to the 2HDM sector the possibility of Higgs-to-Higgs decays with three different Higgs bosons. In this paper the N2HDM is subjected to detailed scrutiny. Regarding the theoretical constraints we implement tests of tree-level perturbativity and vacuum stability. Moreover, we present, for the first time, a thorough analysis of the global minimum of the N2HDM. The model and the theoretical constraints have been implemented in ScannerS, and we provide N2HDECAY, a code based on HDECAY, for the computation of the N2HDM branching ratios and total widths including the state-of-the-art higher order QCD corrections and off-shell decays. We then perform an extensive parameter scan in the N2HDM parameter space, with all theoretical and experimental constraints applied, and analyse its allowed regions. We find that large singlet admixtures are still compatible with the Higgs data and investigate which observables will allow to restrict the singlet nature most effectively in the next runs of the LHC. Similarly to the 2HDM, the N2HDM exhibits a wrong-sign parameter regime, which will be constrained by future Higgs precision measurements.

  11. Brazil and CERN get closer

    CERN Multimedia

    2002-01-01

    The map of countries affiliated to CERN may in future include Brazil. On a visit to CERN last week, the Brazilian Minister of State for Science and Technology, Ronaldo Mota Sardenberg, expressed his country's interest in closer links to the Laboratory.   Luciano Maiani and the Brazilian Minister of State for Science and Technology Ronaldo Mota Sardenberg shake hands on CERN-Brazil co-operation. During his visit, the Minister and CERN Director General Luciano Maiani issued a joint statement for the continuation of a Co-operation Agreement first established in 1990. They also agreed to study the possibility of Brazil joining CERN-led Grid computing infrastructure projects. Brazilian physicists are already involved in the LHCb, ATLAS and CMS experiments. At the conclusion of the Minister's visit, he and Director-General Maiani agreed to establish a Working Group to examine ways of strengthening Brazil's links with CERN, and to prepare the way for a Brazilian request to CERN Council to become an Observer at th...

  12. Source Attributions and Persuasion: Perceived Honesty as a Determinant of Message Scrutiny.

    Science.gov (United States)

    Priester, Joseph R.; Petty, Richard E.

    1995-01-01

    Examined hypothesis that cognitive misers (CM)--individuals low in the need for cognition--forego effortful message scrutiny with a presumably truthful communicator. Results showed that CMs depended more on message scrutiny when a knowledgeable source is of questionable honesty than when the source's honesty is clear. Other factors are discussed.…

  13. victoria cross awards warrants concerning the victoria cross (1920)

    African Journals Online (AJOL)

    1. WARRANTS CONCERNING THE. VICTORIA CROSS (1920). In order to get a picture of the Royal Warrants promulgated from 1856 to 1920 in respect of the .... to confirmation by us. Eighthly. - It is ordained, where such an act shall not have been performed in the sight of a commanding officer as aforesaid, then the ...

  14. 19 CFR 162.11 - Authority to procure warrants.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Authority to procure warrants. 162.11 Section 162.11 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) INSPECTION, SEARCH, AND SEIZURE Search Warrants § 162.11 Authority to procure...

  15. Reliability in Plantinga´s Account of Epistemic Warrant

    Directory of Open Access Journals (Sweden)

    John C. Wingard, Jr.

    2002-12-01

    Full Text Available In das paper 1 consider the reliability condition in Alvin Platinga’s proper functionalist account of epistemic warrant I begin by reviewing m some detail the features of the reliability condition as Platinga has articulated a From there, 1 consider what is needed to ground or secure the sort of reliability which Plantinga has m mind, and argue that what is needed is a significant causal condition which has generally been overlooked Then, after identifying eight versions of the relevant sort of reliability, I exam me each alternative as to whether as requirement, along with Platinga’s other proposed conditions, would give us a satisfactory account of epistemic warrant I conclude that there is bale to no hope of formulating a reliability condition that would yield a satisfactory analysts of the sort Plantinga desires

  16. IFRS 8 Operating Segments - A Closer Look

    OpenAIRE

    Muthupandian, K S

    2008-01-01

    The International Accounting Standards Board issued the International Financial Reporting Standard 8 Operating Segments. Segment information is one of the most vital aspects of financial reporting for investors and other users. The IFRS 8 requires an entity to adopt the ‘management approach’ to reporting on the financial performance of its operating segments. This article presents a closer look of the standard (objective, scope, and disclosures).

  17. A closer look at web questionnaire design

    OpenAIRE

    Toepoel, V.

    2008-01-01

    This dissertation deals with the design of online questionnaires and its consequences for data quality: what is the effect of the number of items placed on a screen, the response categories, layout choices et cetera. It also focuses on attrition and panel conditioning: what do people learn from taking surveys both in content and in the response process. In short: A Closer Look at Web Questionnaire Design.

  18. Clinical pathways for inborn errors of metabolism: warranted and feasible

    Directory of Open Access Journals (Sweden)

    Demirdas Serwet

    2013-02-01

    Full Text Available Abstract Inborn errors of metabolism (IEMs are known for their low prevalence and multidisciplinary care mostly founded on expert opinion. Clinical pathways are multidisciplinary tools to organise care which provide a clear route to the best care and improve communication. In 2010 the Dutch Society for Children and Adults with an Inborn Error of Metabolism (VKS initiated development of clinical pathways for inborn errors of metabolism. In this letter to the editor we describe why it is warranted to develop clinical pathways for IEMs and shortly discuss the process of development for these pathways in the Netherlands.

  19. Positive mood can increase or decrease message scrutiny: the hedonic contingency view of mood and message processing.

    Science.gov (United States)

    Wegener, D T; Petty, R E; Smith, S M

    1995-07-01

    Currently dominant explanations of mood effects on persuasive message processing (i.e., cognitive capacity and feelings as information) predict that happy moods lead to less message scrutiny than neutral or sad moods. The hedonic contingency view (D. T. Wegener & R. E. Petty, 1994) predicts that happy moods can sometimes be associated with greater message processing activity because people in a happy mood are more attentive than neutral or sad people to the hedonic consequences of their actions. Consistent with this view, Experiment 1 finds that a happy mood can lead to greater message scrutiny than a neutral mood when the message is not mood threatening. Experiment 2 finds that a happy mood leads to greater message scrutiny than a sad mood when an uplifting message is encountered, but to less message scrutiny when a depressing message is encountered.

  20. Black-Scholes finite difference modeling in forecasting of call warrant prices in Bursa Malaysia

    Science.gov (United States)

    Mansor, Nur Jariah; Jaffar, Maheran Mohd

    2014-07-01

    Call warrant is a type of structured warrant in Bursa Malaysia. It gives the holder the right to buy the underlying share at a specified price within a limited period of time. The issuer of the structured warrants usually uses European style to exercise the call warrant on the maturity date. Warrant is very similar to an option. Usually, practitioners of the financial field use Black-Scholes model to value the option. The Black-Scholes equation is hard to solve analytically. Therefore the finite difference approach is applied to approximate the value of the call warrant prices. The central in time and central in space scheme is produced to approximate the value of the call warrant prices. It allows the warrant holder to forecast the value of the call warrant prices before the expiry date.

  1. Guarding EU-wide Counter-terrorism Policing: The Struggle for Sound Parliamentary Scrutiny of Europol

    Directory of Open Access Journals (Sweden)

    Claudia Hillebrand

    2011-12-01

    Full Text Available Since the terrorist attacks in New York and Washington, DC (2001, Madrid (2004 and London (2005, the European Union (EU has stepped up its efforts to develop new instruments and reinforce existing ones to fight terrorism jointly. One of the key aspects of the EU-wide fight against terrorism and serious crime is the facilitation and enforcement of information and intelligence exchange among law enforcement authorities and, to a limited extent, security and intelligence services. This article examines how far the EU’s commitment to democracy, accountability and transparency is actually fulfilled with respect to its efforts at fighting terrorism by drawing on the example of the activities of the European Police Office (Europol. Taking the European Parliament (EP and National Parliaments (NPs, but also inter-parliamentary forums, into account, the article analyses how, and to what extent, mechanisms of democratic accountability and, in particular, parliamentary scrutiny are in place to hold EU-wide counter-terrorism actors, such as Europol, to account. This is a particularly timely question given that Europol’s parliamentary scrutiny procedures are currently subject to considerable changes due to the change in its legal mandate as of 1 January 2010 and the entry into force of the Lisbon Treaty.

  2. Adaptation of warrant price with Black Scholes model and historical volatility

    Science.gov (United States)

    Aziz, Khairu Azlan Abd; Idris, Mohd Fazril Izhar Mohd; Saian, Rizauddin; Daud, Wan Suhana Wan

    2015-05-01

    This project discusses about pricing warrant in Malaysia. The Black Scholes model with non-dividend approach and linear interpolation technique was applied in pricing the call warrant. Three call warrants that are listed in Bursa Malaysia were selected randomly from UiTM's datastream. The finding claims that the volatility for each call warrants are different to each other. We have used the historical volatility which will describes the price movement by which an underlying share is expected to fluctuate within a period. The Black Scholes model price that was obtained by the model will be compared with the actual market price. Mispricing the call warrants will contribute to under or over valuation price. Other variables like interest rate, time to maturity date, exercise price and underlying stock price are involves in pricing call warrants as well as measuring the moneyness of call warrants.

  3. The effect of self-scrutiny on improving women’s self-esteem: A case study of Esfahan women

    Directory of Open Access Journals (Sweden)

    Farzaneh Monjezi

    2013-04-01

    Full Text Available The proposed study of this paper investigates the effect of self-scrutiny on improving women’s self-esteem among 50 women who live in city of Esfahan, Iran. There are five hypotheses associated with the proposed study of this paper, which investigate whether teaching self-scrutiny skills increase women’s total, educational-vocational, general, social and family self-esteem. The proposed study of this paper uses three groups of pre-test post-test and control groups and it has been executed among 50 women aged 20-35 who lived in city of Esfahan, Iran based on Coopersmith questionnaire. The results of ANOVA test confirm all five hypotheses of this survey. In other words, scrutiny skills increase women’s total, educational-vocational, general, social and family self-esteem after control group participate in our training programs.

  4. A long walk to obedience: Missiology and mission under scrutiny (1910-2010

    Directory of Open Access Journals (Sweden)

    Johannes J. Knoetze

    2017-05-01

    Full Text Available This article describes the discipline of missiology and mission over the last century since Edinburgh 1910 followed by two world wars to Edinburgh 2010, as a long walk to obedience – a walk in discerning God’s will. Even in biblical times, mission as spreading the gospel to those who do not yet believe in the Trinitarian God, was under scrutiny from within and outside the church (cf. Ac 10-11, 15 and Galatians. Throughout history until today it was never different. This article looks at the development of mission over the last 100 years from a Western (mainline missionary churches – MMCs perspective. The development of missiology as a subject and theological discipline will be described along the lines of some of the mission conferences. Attention will be given to the following questions: What does it mean to b eobedient to the mission calling in a broken and traumatised world? Is there a credible way of redeeming mission and missiology from its own past?

  5. EU Citizenship and European Arrest Warrant: The Same Rights for All?

    NARCIS (Netherlands)

    Marguery, T.P.

    2011-01-01

    In the case Wolzenburg, the principle of non-discrimination of European Union citizens is applied to the European arrest warrant. The implementation of the European arrest warrant by the Member States cannot escape a control of proportional- ity made by the Court. Member States may impose a period

  6. 8 CFR 287.3 - Disposition of cases of aliens arrested without warrant.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Disposition of cases of aliens arrested without warrant. 287.3 Section 287.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS FIELD OFFICERS; POWERS AND DUTIES § 287.3 Disposition of cases of aliens arrested without warrant...

  7. 8 CFR 287.9 - Criminal search warrant and firearms policies.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Criminal search warrant and firearms policies. 287.9 Section 287.9 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS FIELD OFFICERS; POWERS AND DUTIES § 287.9 Criminal search warrant and firearms policies. (a) A...

  8. Behavioral Preferences for Individual Securities : The Case for Call Warrants and Call Options

    NARCIS (Netherlands)

    Ter Horst, J.R.; Veld, C.H.

    2002-01-01

    Since 1998, large investment banks have flooded the European capital markets with issues of call warrants.This has led to a unique situation in the Netherlands, where now call warrants, traded on the stock exchange, and long-term call options, traded on the options exchange, exist.Both entitle their

  9. Homotopy Analysis Method for Boundary-Value Problem of Turbo Warrant Pricing under Stochastic Volatility

    Directory of Open Access Journals (Sweden)

    Hoi Ying Wong

    2013-01-01

    Full Text Available Turbo warrants are liquidly traded financial derivative securities in over-the-counter and exchange markets in Asia and Europe. The structure of turbo warrants is similar to barrier options, but a lookback rebate will be paid if the barrier is crossed by the underlying asset price. Therefore, the turbo warrant price satisfies a partial differential equation (PDE with a boundary condition that depends on another boundary-value problem (BVP of PDE. Due to the highly complicated structure of turbo warrants, their valuation presents a challenging problem in the field of financial mathematics. This paper applies the homotopy analysis method to construct an analytic pricing formula for turbo warrants under stochastic volatility in a PDE framework.

  10. Stormy weather. Echoes of Columbia/HCA heard as Tenet overhauls management amid scrutiny of outliner payments and investor protests.

    Science.gov (United States)

    Galloro, Vince

    2002-11-11

    What began as a small shower of questions quickly transformed into a storm of investor protest last week as Tenet Healthcare Corp. underwent a management overhaul and analysts asked questions about its fiscal future. Tenet's business strategy came under scrutiny because a large proportion of its Medicare revenue was generated by so-called outlier payments. Chairman and CEO Jeffrey Barbakow (left) says that's not how he wants to do business.

  11. 26 CFR 1.414(r)-6 - Qualified separate line of business-administrative scrutiny requirement-individual determinations.

    Science.gov (United States)

    2010-04-01

    ...-administrative scrutiny requirement-individual determinations. 1.414(r)-6 Section 1.414(r)-6 Internal Revenue... Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.414(r)-6 Qualified separate line of business... determined under § 1.414(r)-3) that does not satisfy any of the safe harbors in § 1.414(r)-5 for a testing...

  12. Move Closer: Towards Design Patterns To Support Initiating Social Encounters

    DEFF Research Database (Denmark)

    Mitchell, Robb; Boer, Laurens

    2017-01-01

    be addressed. Each inspirational design pattern offers strategies to make social interaction more likely through enabling, encouraging or excusing people to move closer together. The patterns are "Feel For Fun", "Conjoining Self Images", "Eye To Eye", and "Nudge People Together". Articulating possible...... approaches for increasing conviviality may broaden the repertoire of developers concerned with social settings and collaboration....

  13. Europe edges closer to an integrated science policy

    CERN Multimedia

    Schiermeier, Q

    2000-01-01

    At a meeting in Luxembourg last week, the research ministers of the 15 member states of the EU fixed a schedule for changes intended to forge closer links between the science activities and policies pursued by individual member states (1 page).

  14. Right-­turn traffic volume adjustment in traffic signal warrant analysis : final report.

    Science.gov (United States)

    2016-05-06

    This report was based on the research project, Right-Turn Traffic Volume Adjustment in Traffic Signal Warrants, sponsored by the Nevada Department of Transportation (NDOT) and SOLARIS. Right-turn traffic does not affect intersection performance in th...

  15. Right-\\0xADturn traffic volume adjustment in traffic signal warrant analysis : final report.

    Science.gov (United States)

    2016-05-06

    This report was based on the research project, Right-Turn Traffic Volume Adjustment in : Traffic Signal Warrants, sponsored by the Nevada Department of Transportation (NDOT) : and SOLARIS. Right-turn traffic does not affect intersection performance i...

  16. From Four to Two: Transformation of the Army Ordnance Officer and Warrant Officer Corps

    National Research Council Canada - National Science Library

    Napier, Joyce

    2003-01-01

    .... This study will examine how senior leaders within the Army and specifically the Ordnance Corps must change the officer and warrant officer force structure education system and leader development...

  17. Tax Policy and Sole Proprietorships: A Closer Look

    OpenAIRE

    Nelson, Susan C.

    2008-01-01

    The 21 million sole proprietorship returns filed in 2005 represent a wide variety of economic activity. This paper examines three major tax policy issues related to sole proprietorships—taxpayer compliance, taxpayer burden, and incentives for growth. It uses tax return data to take a closer look at sole proprietorships. It proposes a new taxonomy for describing these returns in an economically meaningful way, based on the principal factors of production that they use: their own labor, hired l...

  18. Enforcement Alert: Hazardous Waste Management Practices at Mineral Processing Facilities Under Scrutiny by U.S. EPA; EPA Clarifies 'Bevill Exclusion' Wastes and Establishes Disposal Standards

    Science.gov (United States)

    This is the enforcement alert for Hazardous Waste Management Practices at Mineral Processing Facilities Under Scrutiny by U.S. EPA; EPA Clarifies 'Bevill Exclusion' Wastes and Establishes Disposal Standards

  19. Intraday Trading Patterns in the Equity Warrants and Equity Options Markets: Australian Evidence

    Directory of Open Access Journals (Sweden)

    Lydia Segara

    2007-06-01

    Full Text Available This paper extends the microstructure literature, by examining the previouslyundocumented intraday trading patterns in trading volume, price volatility, order depthand relative spreads for both the warrant and option market in Australia. Comparisons ofintraday variations across these derivative securities allows for insight to be drawn intocompeting market microstructure theories and provides the opportunity to examinewhether market design differences explain variations in observed intraday patterns. Wefind that intraday trading patterns documented in the warrant and option markets can beexplained by their market designs, along with theories relating to time-varying informationasymmetry and time-varying hedging trades around nontrading periods.

  20. Show me the goods: The warranting effect of user-generated photographs in online auctions

    NARCIS (Netherlands)

    Johnson, B.K.; Vang, M.H.; van der Heide, B.

    2015-01-01

    Consumers using online auction websites face the challenge of appraising products at a distance. Sellers and buyers in online auctions navigate this challenge by displaying and evaluating various cues, a critical one being use of photographs. Warranting theory predicts that cues less subject to

  1. Angioedema Spotlight: A Closer Examination of Sacubitril/Valsartan Safety Results.

    Science.gov (United States)

    Owens, Ryan E; Oliphant, Carrie S

    2017-01-01

    Incorporation of neprilysin inhibition into heart failure pharmacotherapy regimens has recently been recommended by U.S. guidelines, based on results from the PARADIGM-HF trial comparing sacubitril/valsartan to enalapril. While most of the discussion has focused on efficacy, a closer examination of the safety results, particularly the incidence of angioedema during the run-in and double-blind periods, is also warranted. Although no major safety concerns were identified, an angioedema risk comparable to enalapril was found, primarily in the black population. Therefore, despite combination with an angiotensin receptor blocker, which historically has a lower incidence of angioedema, the addition of neprilysin inhibition yields an angioedema risk profile comparable to angiotensin converting enzyme (ACE) inhibitors. Clinicians should recognize this safety risk when prescribing sacubitril/valsartan and remain vigilant in counseling patients regarding the signs and symptoms of angioedema. As recommended by the guidelines, avoiding sacubitril/valsartan use concurrently or within 36 hours of the last dose of an ACE inhibitor or in patients with a history of angioedema is also crucial to minimize angioedema risk and prevent patient harm. © Copyright 2017 by the American Board of Family Medicine.

  2. Move Closer: Towards Design Patterns To Support Initiating Social Encounters

    DEFF Research Database (Denmark)

    Mitchell, Robb; Boer, Laurens

    2017-01-01

    This paper offers four inspirational design patterns concerned with reducing inhibitions for unacquainted co-located people to interact. These patterns identify impediments to interpersonal contact in relation to the distances between people and present diverse examples of how these challenges may...... be addressed. Each inspirational design pattern offers strategies to make social interaction more likely through enabling, encouraging or excusing people to move closer together. The patterns are "Feel For Fun", "Conjoining Self Images", "Eye To Eye", and "Nudge People Together". Articulating possible...

  3. Hepatic encephalopathy: Ever closer to its big bang.

    Science.gov (United States)

    Souto, Pablo A; Marcotegui, Ariel R; Orbea, Lisandro; Skerl, Juan; Perazzo, Juan Carlos

    2016-11-14

    Hepatic encephalopathy (HE) is a neuropsychiatric disorder that commonly complicates the course of patients with liver disease. Despite the fact that the syndrome was probably first recognized hundreds of years ago, the exact pathogenesis still remains unclear. Minimal hepatic encephalopathy (MHE) is the earliest form of HE and is estimated to affect more that 75% of patients with liver cirrhosis. It is characterized by cognitive impairment predominantly attention, reactiveness and integrative function with very subtle clinical manifestations. The development of MHE is associated with worsen in driving skills, daily activities and the increase of overall mortality. Skeletal muscle has the ability to shift from ammonia producer to ammonia detoxifying organ. Due to its large size, becomes the main ammonia detoxifying organ in case of chronic liver failure and muscular glutamine-synthase becomes important due to the failing liver and brain metabolic activity. Gut is the major glutamine consumer and ammonia producer organ in the body. Hepatocellular dysfunction due to liver disease, results in an impaired clearance of ammonium and in its inter-organ trafficking. Intestinal bacteria, can also represent an extra source of ammonia production and in cirrhosis, small intestinal bacterial overgrowth and symbiosis can be observed. In the study of HE, to get close to MHE is to get closer to its big bang; and from here, to travel less transited roads such as skeletal muscle and intestine, is to go even closer. The aim of this editorial is to expose this road for further and deeper work.

  4. A review on Black-Scholes model in pricing warrants in Bursa Malaysia

    Science.gov (United States)

    Gunawan, Nur Izzaty Ilmiah Indra; Ibrahim, Siti Nur Iqmal; Rahim, Norhuda Abdul

    2017-01-01

    This paper studies the accuracy of the Black-Scholes (BS) model and the dilution-adjusted Black-Scholes (DABS) model to pricing some warrants traded in the Malaysian market. Mean Absolute Error (MAE) and Mean Absolute Percentage Error (MAPE) are used to compare the two models. Results show that the DABS model is more accurate than the BS model for the selected data.

  5. Supernatural/Paranormal Phenomena: A Passionate Closer Look

    Science.gov (United States)

    Hameed, S.; Robinson, G.; Maulton, J.

    2003-05-01

    A collaboration between a psychologist, a philosopher, and an astronomer resulted in an inter-term (January) course, titled "Supernatural/Paranormal Phenomena: A Passionate Closer Look" at Smith College. The main purpose of the course was to provide students with the tools to evaluate the pseudo-sciences that are so enticing in today's complex and stressful world. We examined some of the reasons why people are attracted to New-Age enterprises that claim to: provide personal insight and social guidance from stars and planets; communicate with the dead; predict the future; prove contact with extraterrestrial beings. The course provided us with an opportunity to introduce the methodology of science and compare it with the claims made by the defenders of pseudo-sciences. We also conducted a survey of paranormal beliefs of enrolled students before and after our inter-term class.

  6. Norway [and the closer relations with the European Community

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    Opinion in Norway seems to have settled on the idea that having a closer relation to the EC is inevitable, although opinion is divided as to whether this will be a good thing. The plain fact is that with Denmark already involved and the Swedes thinking about it, some Norwegian politicians are nervous about being left out in the cold. However, this feeling of inevitability does not mean that the EC can treat Norway's curious economy like an oyster, to be cracked open and eaten at a time of its own choosing. The Norweigians are, after all, sitting on Western Europe's largest and most secure hydrocarbon reserves for export, and they also have hydropower. The situation in which these resources place Norway are examined with respect to EC membership. (author)

  7. Execution of the European Arrest Warrant by the Romanian Judicial Authorities

    Directory of Open Access Journals (Sweden)

    Ion Rusu

    2009-06-01

    Full Text Available The unprecedented development of criminality at the social and economical levels, the tendency toglobalize some categories of crimes, of maximum gravity, as terrorism, armament traffic, drug traffic orhuman traffic, have determined the world states to undertake specific measures to prevent, combat and finallyreduce it. The first and most important measure taken by the Europe’s Council, regarding the intensificationof judicial cooperation in criminal matters was the adoption of the European Convention on extradition, inParis on 13 December 1957, completed by the two Additional Protocols in Strasbourg, on 15 October 1975and 17 March 1978. In this context, the release of the Council’s Framework Decision on 13 June 2002 on theEuropean arrest warrant and the procedures of delivery among the member states (2002/584/JAI representeda natural decision, with the purpose of contributing at ensuring a free, secure and just European space. TheEuropean arrest warrant is a judicial decision through which a competent judicial authority of a EuropeanUnion member state solicits the arrest and delivery by another member state, in order to proceed to theprosecution, trial or execution of a penalty or safety measure that is privative of freedom.

  8. Diagnosing true virtue? Remote scenarios, warranted virtue attributions, and virtuous medical practice.

    Science.gov (United States)

    Oakley, Justin

    2016-02-01

    Immanuel Kant argues in the Foundations that remote scenarios are diagnostic of genuine virtue. When agents commonly thought to have a particular virtue fail to exhibit that virtue in an extreme situation, he argues, they do not truly have the virtue at all, and our propensities to fail in such ways indicate that true virtue might never have existed. Kant's suggestion that failure to show, say, courage in extraordinary circumstances necessarily silences one's claim to have genuine courage seems to rely on an implausibly demanding standard for warranted virtue attributions. In contrast to this approach, some philosophers-such as Robert Adams and John Doris-have argued for probabilistic accounts of warranted virtue attributions. But despite the initial plausibility of such accounts, I argue that a sole reliance on probabilistic approaches is inadequate, as they are insufficiently sensitive to considerations of credit and fault, which emerge when agents have developed various insurance strategies and protective capacities against their responding poorly to particular eventualities. I also argue that medical graduates should develop the sorts of virtuous dispositions necessary to protect patient welfare against various countervailing influences (even where such influences might be encountered only rarely), and that repeated failures to uphold the proper goals of medicine in emergency scenarios might indeed be diagnostic of whether an individual practitioner does have the relevant medical virtue. In closing, I consider the dispositions involved in friendship. I seek to develop a principled way of determining when remote scenarios can be illuminating of genuine friendship and genuine virtue.

  9. White certificates in an oligopoly market: closer to reality?

    Energy Technology Data Exchange (ETDEWEB)

    Oikonomou, Vlasis (SOM, Univ. of Groningen, Groningen (Netherlands)); Giacomo, Marina Di (Univ. of Torino, Dept. di Scienze Economiche e Finanziarie, Torino (Italy)); Russolillo, Daniele (Fondazione per l' Ambiente ' T. Fenoglio' (Italy)); Becchis, Franco (Univ. of East Piedmont, POLIS Dept., Environmental Economics (Italy))

    2009-07-01

    In this paper we depart from neoclassical assumptions of fully competitive energy markets, and attempt to represent an oligopolistic market, which is closer to reality than a fully competitive environment given the reconsolidation tendencies of energy companies. We focus mainly on the effects of energy policies for energy efficiency improvement, namely on supplier obligations and White Certificates in an oligopoly market. In particular we concentrate on two of the most common oligopolistic models: the Cournot and the Stackelberg model where agents are assumed to strategically interact (unlike perfect competition where firms behave atomistically). In these two game theoretically based models the behaviour of each market actor is based on a detailed decision tree, which determines the optimal move given the expectations on the competitor's strategy. According to our preliminary findings, the price of electricity is always higher under the symmetric Cournot model than the Stackelberg one, but the introduction of white certificate obligations should encompass larger increases in the electricity prices in a Stackelberg game. In order to test our theoretical findings we make use of a typical oligopolistic market in Italy, where we depict that a leader company can serve the main part of electricity and energy efficiency projects, through financing them with White Certificates, while the residual demand is more expensive and must be covered at a high cost from follower companies.

  10. Bringing MapReduce Closer To Data With Active Drives

    Science.gov (United States)

    Golpayegani, N.; Prathapan, S.; Warmka, R.; Wyatt, B.; Halem, M.; Trantham, J. D.; Markey, C. A.

    2017-12-01

    Moving computation closer to the data location has been a much theorized improvement to computation for decades. The increase in processor performance, the decrease in processor size and power requirement combined with the increase in data intensive computing has created a push to move computation as close to data as possible. We will show the next logical step in this evolution in computing: moving computation directly to storage. Hypothetical systems, known as Active Drives, have been proposed as early as 1998. These Active Drives would have a general-purpose CPU on each disk allowing for computations to be performed on them without the need to transfer the data to the computer over the system bus or via a network. We will utilize Seagate's Active Drives to perform general purpose parallel computing using the MapReduce programming model directly on each drive. We will detail how the MapReduce programming model can be adapted to the Active Drive compute model to perform general purpose computing with comparable results to traditional MapReduce computations performed via Hadoop. We will show how an Active Drive based approach significantly reduces the amount of data leaving the drive when performing several common algorithms: subsetting and gridding. We will show that an Active Drive based design significantly improves data transfer speeds into and out of drives compared to Hadoop's HDFS while at the same time keeping comparable compute speeds as Hadoop.

  11. Does Male Circumcision Protect against Sexually Transmitted Infections? Arguments and Meta-Analyses to the Contrary Fail to Withstand Scrutiny.

    Science.gov (United States)

    Morris, Brian J; Hankins, Catherine A; Tobian, Aaron A R; Krieger, John N; Klausner, Jeffrey D

    2014-01-01

    We critically evaluate a recent article by Van Howe involving 12 meta-analyses that concludes, contrary to current evidence, that male circumcision increases the risk of various common sexually transmitted infections (STIs). Our detailed scrutiny reveals that these meta-analyses (1) failed to include results of all relevant studies, especially data from randomized controlled trials, (2) introduced bias through use of inappropriate control groups, (3) altered original data, in the case of human papillomavirus (HPV), by questionable adjustments for "sampling bias," (4) failed to control for confounders through use of crude odds ratios, and (5) used unnecessarily complicated methods without adequate explanation, so impeding replication by others. Interventions that can reduce the prevalence of STIs are important to international health. Of major concern is the global epidemic of oncogenic types of HPV that contribute to the burden of genital cancers. Meta-analyses, when well conducted, can better inform public health policy and medical practice, but when seriously flawed can have detrimental consequences. Our critical evaluation leads us to reject the findings and conclusions of Van Howe on multiple grounds. Our timely analysis thus reaffirms the medical evidence supporting male circumcision as a desirable intervention for STI prevention.

  12. Buffered or under Scrutiny?

    DEFF Research Database (Denmark)

    Klopf, Patricia; Nell, Phillip C.; Puck, Jonas

    – they are to a stronger extent buffered from the external environment than small firms. Thus, this paper adds to previous research by disentangling the complex effects of size on the use of political strategies – a strand of literature which has been characterized by inconsistent findings in the past.......This paper investigates political strategies of MNE subsidiaries operating in emerging markets. Our findings support previous findings of more intense political strategies in the presence of stronger institutional pressures from public and private stakeholders. Furthermore, we hypothesize...

  13. Unreliable patient identification warrants ABO typing at admission to check existing records before transfusion.

    Science.gov (United States)

    Ferrera-Tourenc, V; Lassale, B; Chiaroni, J; Dettori, I

    2015-06-01

    This study describes patient identification errors leading to transfusional near-misses in blood issued by the Alps Mediterranean French Blood Establishment (EFSAM) to Marseille Public Hospitals (APHM) over an 18-month period. The EFSAM consolidates 14 blood banks in southeast France. It supplies 149 hospitals and maintains a centralized database on ABO types used at all area hospitals. As an added precaution against incompatible transfusion, the APHM requires ABO testing at each admission regardless of whether the patient has an ABO record. The study goal was to determine if admission testing was warranted. Discrepancies between ABO type determined by admission testing and records in the centralized database were investigated. The root cause for each discrepancy was classified as specimen collection or patient admission error. Causes of patient admission events were further subclassified as namesake (name similarity) or impersonation (identity fraud). The incidence of ABO discrepancies was 1:2334 including a 1:3329 incidence of patient admission events. Impersonation was the main cause of identity events accounting for 90.3% of cases. The APHM's ABO control policy prevented 19 incompatible transfusions. In relation to the 48,593 packed red cell units transfused, this would have corresponded to a risk of 1:2526. Collecting and storing ABO typing results in a centralized database is an essential public health tool. It allows crosschecking of current test results with past records and avoids redundant testing. However, as patient identification remains unreliable, ABO typing at each admission is still warranted to prevent transfusion errors. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  14. Placing the pieces: Reconstructing the original property mosaic in a warrant and patent watershed

    Science.gov (United States)

    Bain, D.J.; Brush, G.S.

    2005-01-01

    Recent research shows that land use history is an important determinant of current ecosystem function. In the United States, characterization of land use change following European settlement requires reconstruction of the original property mosaic. However, this task is difficult in unsystematically surveyed areas east of the Appalachian Mountains. The Gwynns Falls watershed (Baltimore, MD) was originally surveyed in the 1600-1700s under a system of warrants and patents (commonly known as 'metes and bounds'). A method for the reconstruction and mapping of warrant and patent properties is presented and used to map the original property mosaic in the Gwynns Falls watershed. Using the mapped mosaic, the persistence of properties and property lines in the current Gwynns Falls landscape is considered. The results of this research indicate that as in agricultural areas, the original property lines in the Gwynns Falls watershed are persistent. At the same time, the results suggest that the property mosaic in heavily urbanized/suburbanized areas is generally 'reset.' Further, trends in surveying technique, parcel size, and settlement patterns cause property line density and property shape complexity to increase in the less urbanized upper watershed. The persistence of original patterns may be damping expression of heterogeneity gradients in this urban landscape. This spatial pattern of complexity in the original mosaic is directly opposite of hypothesized patterns of landscape heterogeneity arising from urbanization. The technique reported here and the resulting observations are important for landscape pattern studies in areas settled under unsystematic survey systems, especially the heavily urbanized areas of the eastern United States. ?? 2004 Kluwer Academic Publishers.

  15. A service model for delivering care closer to home.

    Science.gov (United States)

    Dodd, Joanna; Taylor, Charlotte Elizabeth; Bunyan, Paul; White, Philippa Mary; Thomas, Siân Myra; Upton, Dominic

    2011-04-01

    Upton Surgery (Worcestershire) has developed a flexible and responsive service model that facilitates multi-agency support for adult patients with complex care needs experiencing an acute health crisis. The purpose of this service is to provide appropriate interventions that avoid unnecessary hospital admissions or, alternatively, provide support to facilitate early discharge from secondary care. Key aspects of this service are the collaborative and proactive identification of patients at risk, rapid creation and deployment of a reactive multi-agency team and follow-up of patients with an appropriate long-term care plan. A small team of dedicated staff (the Complex Care Team) are pivotal to coordinating and delivering this service. Key skills are sophisticated leadership and project management skills, and these have been used sensitively to challenge some traditional roles and boundaries in the interests of providing effective, holistic care for the patient.This is a practical example of early implementation of the principles underlying the Department of Health's (DH) recent Best Practice Guidance, 'Delivering Care Closer to Home' (DH, July 2008) and may provide useful learning points for other general practice surgeries considering implementing similar models. This integrated case management approach has had enthusiastic endorsement from patients and carers. In addition to the enhanced quality of care and experience for the patient, this approach has delivered value for money. Secondary care costs have been reduced by preventing admissions and also by reducing excess bed-days. The savings achieved have justified the ongoing commitment to the service and the staff employed in the Complex Care Team. The success of this service model has been endorsed recently by the 'Customer Care' award by 'Management in Practice'. The Surgery was also awarded the 'Practice of the Year' award for this and a number of other customer-focussed projects.

  16. Carotid sinus hypersensitivity: Entity warrants a caution in the critical care unit

    Directory of Open Access Journals (Sweden)

    Sugata Dasgupta

    2016-01-01

    Full Text Available Carotid sinus hypersensitivity (CSH syndrome is an entity caused by an overreaction of the carotid sinus baroreceptors to stimulation. Three subtypes of CSH syndrome are recognized according to the response to carotid sinus massage (CSM: Predominantly cardioinhibitory, predominantly vasodepressor and a mixed subtype. We report here the case of a middle-aged female patient admitted in our critical care unit with respiratory failure requiring mechanical ventilation. There were episodes of severe bradycardia whenever her head was rotated to any side, relieved on neutralizing head position and administering intravenous atropine. CSM revealed she had predominantly cardioinhibitory type of CSH syndrome. A cardioinhibitory form of hypersensitive carotid sinus reflex, which is idiopathic in causation, probably explains the severe bradycardia on head rotation seen in our patient. A heightened awareness of this syndrome is necessary for timely diagnosis and management. CSH syndrome results from an overreaction of the carotid sinus baroreceptors to stimulation, manifesting commonly as bradycardia, hypotension and syncope. It is an entity, which warrants caution during routine critical care practices.

  17. Financial oil derivatives: from options to oil warrants and synthetic oilfields

    International Nuclear Information System (INIS)

    Trabia, Xavier

    1992-01-01

    This study aims to shed light on some of the most interesting financial oil derivatives issued so far in order to assess the potential of this new wave of innovative funding instruments. In Part I some theoretical background is provided and applied to the problem of the American futures option. The ''binomial'' model for valuing future option contracts is presented and the most accurate alternatives for pricing American futures options are reviewed. The role of these numerical procedures in valuing more complex options involved in oil warrants is examined. Comments are made on the behaviour of volatility, which stands as a key interface between theory and practice in oil trading on the oil futures market. Part II of the study describes in detail some of the most famous new financial oil derivatives. Some final conclusions are drawn on the potential of oil trusts and synthetic oilfields to be involved in project and general funding in the oil industry. (44 figures, 11 tables, 53 references) (UK)

  18. One Step Closer to the Marketplace for State-of-the-Art Wind Turbine

    Science.gov (United States)

    Drivetrain | News | NREL One Step Closer to the Marketplace for State-of-the-Art Wind Turbine Drivetrain One Step Closer to the Marketplace for State-of-the-Art Wind Turbine Drivetrain April 1, 2016 modeling, and testing in state-of-the-art facilities designed to put the drivetrain through its paces

  19. The valuation of equity warrants under the fractional Vasicek process of the short-term interest rate

    Science.gov (United States)

    Xiao, Weilin; Zhang, Weiguo; Zhang, Xili; Chen, Xiaoyan

    2014-01-01

    Motivated by the empirical evidence of long range dependence in short-term interest rates and considering the long maturities of equity warrants, we propose the fractional Vasicek model to describe the dynamics of the short rate in the pricing environment of equity warrants. Using the partial differential equation approach, we present a valuation model for equity warrants under the assumption that the short rate follows the fractional Vasicek process. After identifying the pricing model for equity warrants, we provide the parameter estimation procedure for the proposed pricing model. Since obtaining the values of equity warrants from the proposed model needs to solve a nonlinear equation, we employ a hybrid intelligent algorithm to get around this optimization problem. Furthermore, to illustrate the practicality of our proposed model, we conduct an empirical study to ascertain the performance of our proposed model using the data from China’s warrant market and the China Foreign Exchange Trade System. The comparison of traditional models (such as the Black-Scholes model, the Noreen-Wolfson model, the Lauterbach-Schultz model, and the Ukhov model) with our proposed model is also presented. The empirical results show that the mean absolute percentage error of our pricing model is 10.30%. By contrast, the Black-Scholes model, the Noreen-Wolfson model, the Lauterbach-Schultz model, and the Ukhov model applied to the same warrant produce mean absolute errors of 35.26%, 37.67%, 33.40%, 32.81%, respectively. Thus the long memory property in stochastic interest rates cannot be ignored in determining the valuation of equity warrants.

  20. Predictive factors warrant screening for obstructive sleep apnea in COPD: a Taiwan National Survey

    Directory of Open Access Journals (Sweden)

    Hang LW

    2016-03-01

    questionnaire to assess COPD symptoms and OSA risk, comorbidities, and performance of daily activities. Data from COPD cohorts with and without risk of OSA were analyzed and compared. Results: Of 6,600 interviews completed, 404 subjects fit the epidemiological case definition of COPD – an overall prevalence of 6.1% in this national sample. Data on OSA risk were available for 292 of this COPD cohort, of whom 29.5% were at risk of OSA. Compared to those without risk of OSA, those with risk of OSA were significantly more likely to have hypertension or cardiovascular disease and diabetes, had significantly higher body mass index and COPD Assessment Test scores, and reported impaired work performance and leisure activities. Conclusion: Among adults in Taiwan who fulfill epidemiologic criteria for COPD, 29.5% have coexisting risk of OSA. Comorbid hypertension or cardiovascular disease and diabetes are common and significantly more prevalent among the COPD population at risk of OSA than those who are not. OSA screening is warranted in patients with COPD with those risk factors that are more prevalent in COPD with risk of OSA than without, to target early interventions to reduce adverse cardiovascular sequelae from overlap syndrome. Keywords: cardiovascular risk, COPD, coexistent, obstructive sleep apnea, OSA, overlap syndrome

  1. Getting closer: the effects of personalized and interactive online political communication

    NARCIS (Netherlands)

    Kruikemeier, S.; van Noort, G.; Vliegenthart, R.; de Vreese, C.H.

    2013-01-01

    Political parties and politicians increasingly use the possibilities of the Internet to communicate interactively with citizens and vice versa. The Internet also offers opportunities for individual politicians to profile themselves. These developments are often said to bring politics closer to

  2. Announcement effects of convertible bond loans versus warrant-bond loans : An empirical analysis for the Dutch market

    NARCIS (Netherlands)

    de Roon, F.A.; Veld, C.H.

    1995-01-01

    This study investigates the announcement effects of offerings of convertible bond loans and warrant-bond loans using data for the Dutch market. Using standard event study methodology it is found that on average stock prices show a positive but insignificant abnormal return for the announcement of a

  3. 20 CFR 416.934 - Impairments which may warrant a finding of presumptive disability or presumptive blindness.

    Science.gov (United States)

    2010-04-01

    ... Blindness Presumptive Disability and Blindness § 416.934 Impairments which may warrant a finding of presumptive disability or presumptive blindness. We may make findings of presumptive disability and... school, because of mental deficiency or is unable to attend any type of school (or if beyond school age...

  4. Peculiarities of the Enforcement of the European Arrest Warrant in the Case of an Illegal Liberty Deprivation

    Directory of Open Access Journals (Sweden)

    Minodora Ioana Rusu

    2010-06-01

    Full Text Available The illegal deprivation of liberty is, under the current context, one of the most serious offenses, being treated differently in the European Union. The need to prevent and combat this violation, it has led the European legislator to include it under different names in the European legislative act that governs the institution of the European arrest warrant. In this context, the European arrest warrant is the most important form of judicial cooperation in penal matters between the Member States of the EU, which is based on mutualrecognition of criminal judgments. The research conducted on how it is regulated the enforcement of the European arrest warrant in the case of illegal liberty deprivation in the European legislative act (the Framework Decision 2002/584/JHA leads to the conclusion that the legislature failed to mention the violation in question in the group of the violation for which it was not necessary the inspection of the double incrimination, but, still, including the offenses as kidnapping, illegal restraint and hostage-taking. Even if theRomanian legislator included this violation in the above mentioned group, this situation is not solved, because it will cause some problems in the request by the Romanian judicial authorities of the enforcement of such warrant. Another criticized issue, observed not only in the European legislative act, but also in the internal law, is related to the lack of stipulations, which can lead to the possibility of issuing and executing a European arrest warrant and for the execution of educational measures for illegal deprivation of liberty and also others. Also, in order to increase the effectiveness of the execution of a European arrest warrant, we consider that it should be granted executive powers of all courts of Romania. The originality of the work consists of the critical observations and the lege ferenda proposal which covers both the European legislativeact and the Romanian Law. At the same time

  5. A Closer Look at Deep Learning Neural Networks with Low-level Spectral Periodicity Features

    DEFF Research Database (Denmark)

    Sturm, Bob L.; Kereliuk, Corey; Pikrakis, Aggelos

    2014-01-01

    Systems built using deep learning neural networks trained on low-level spectral periodicity features (DeSPerF) reproduced the most “ground truth” of the systems submitted to the MIREX 2013 task, “Audio Latin Genre Classification.” To answer why this was the case, we take a closer look...

  6. Explore: An Action to Bring Science and Technology Closer to Secondary School

    Science.gov (United States)

    Torras-Melenchon, Nuria; Grau, M. Dolors; Font-Soldevila, Josep; Freixas, Josep

    2015-01-01

    This paper presents the experience of an initiative, the EXPLORE courses, designed to bring science and technology closer to secondary school. The EXPLORE courses, organised by "EXPLORATORI: Natural Resources" project, are particularly addressed to secondary school teachers and are conducted at Catalonia (North East of Spain). The main…

  7. Is Bringing Back Warrant Officers the Answer A Loot at How They Could Work in the Air Force Cyber Operations Career Field

    Science.gov (United States)

    2017-03-16

    fulfill that intent. In contrast, the Army, Navy and Marine Corps utilize warrant officers in a multitude of capacities, especially in highly... education and more generalized knowledge of commissioned officers. Warrant officer duties include supervising and managing the execution of cyberspace...trace his or her roots back to the British Royal Navy in the thirteenth century.28 The Crown awarded Royal Warrants to especially experienced sailors to

  8. IAS 8, Accounting Policies, Changes in Accounting Estimates and Errors – A Closer Look

    OpenAIRE

    Muthupandian, K S

    2008-01-01

    The International Accounting Standards Board issued the revised version of the International Accounting Standard 8, Accounting Policies, Changes in Accounting Estimates and Errors. The objective of IAS 8 is to prescribe the criteria for selecting, applying and changing accounting policies, together with the accounting treatment and disclosure of changes in accounting policies, changes in accounting estimates and the corrections of errors. This article presents a closer look of the standard (o...

  9. A closer relationship between working and learning? Employers and distance learners talk about developing work skills

    OpenAIRE

    Pegg, Ann

    2010-01-01

    Across Europe universities are expected to work more closely with employers to ensure that learners develop employability skills for the workplace. Policy discourse suggests that a closer relationship between universities and employers can act as a mechanism to develop employability skills more effectively. This article draws on a small qualitative case study which investigated the “Graduate@Work” initiative undertaken by the Open University. These distance learners, sponsored by their SME em...

  10. Conservation tax rebates under scrutiny

    International Nuclear Information System (INIS)

    Rodgers, L.M.

    1990-01-01

    This article describes federal legislative response to an Internal Revenue Service (IRS) ruling that rebates offered as incentives by utilities are taxable as gross income. A bill is being introduced that will reverse the situation. Statements from various conservation and industry organizations are offered in support of the bill. The IRS is also reviewing its ruling

  11. Scrutiny of Critical Thinking Concept

    Science.gov (United States)

    Atabaki, Ali Mohammad Siahi; Keshtiaray, Narges; Yarmohammadian, Mohammad H.

    2015-01-01

    Learning critical thinking skills are the goal of educational systems so the term "critical thinking" (CT) is frequently found in educational policy documents. Despite this frequency, however, precise understandings among teachers of what CT really means do not exit. The present study is designed to answer the following question. We can…

  12. Measuring the Effect of Housing Quality Interventions: The Case of the New Zealand “Rental Warrant of Fitness”

    Science.gov (United States)

    Telfar-Barnard, Lucy; Bennett, Julie; Howden-Chapman, Philippa; Jacobs, David E.; Ormandy, David; Cutler-Welsh, Matthew; Preval, Nicholas; Baker, Michael G.; Keall, Michael

    2017-01-01

    In New Zealand, as in many other countries, housing in the private-rental sector is in worse condition than in the owner-occupier housing sector. New Zealand residential buildings have no inspection regime after original construction signoff. Laws and regulations mandating standards for existing residential housing are outdated and spread over a range of instruments. Policies to improve standards in existing housing have been notoriously difficult to implement. In this methods paper, we describe the development and implementation of a rental Warrant of Fitness (WoF) intended to address these problems. Dwellings must pass each of 29 criteria for habitability, insulation, heating, ventilation, safety, amenities, and basic structural soundness to reach the WoF minimum standard. The WoF’s development was based on two decades of research on the impact of housing quality on health and wellbeing, and strongly influenced by the UK Housing Health and Safety Rating System and US federal government housing standards. Criteria were field-tested across a range of dwelling types and sizes, cities, and climate zones. The implementation stage of our WoF research consists of a non-random controlled quasi-experimental study in which we work with two city-level local government councils to implement the rental WoF, recruiting adjoining council areas as controls, and measuring changes in health, economic, and social outcomes. PMID:29112147

  13. Measuring the Effect of Housing Quality Interventions: The Case of the New Zealand “Rental Warrant of Fitness”

    Directory of Open Access Journals (Sweden)

    Lucy Telfar-Barnard

    2017-11-01

    Full Text Available In New Zealand, as in many other countries, housing in the private-rental sector is in worse condition than in the owner-occupier housing sector. New Zealand residential buildings have no inspection regime after original construction signoff. Laws and regulations mandating standards for existing residential housing are outdated and spread over a range of instruments. Policies to improve standards in existing housing have been notoriously difficult to implement. In this methods paper, we describe the development and implementation of a rental Warrant of Fitness (WoF intended to address these problems. Dwellings must pass each of 29 criteria for habitability, insulation, heating, ventilation, safety, amenities, and basic structural soundness to reach the WoF minimum standard. The WoF’s development was based on two decades of research on the impact of housing quality on health and wellbeing, and strongly influenced by the UK Housing Health and Safety Rating System and US federal government housing standards. Criteria were field-tested across a range of dwelling types and sizes, cities, and climate zones. The implementation stage of our WoF research consists of a non-random controlled quasi-experimental study in which we work with two city-level local government councils to implement the rental WoF, recruiting adjoining council areas as controls, and measuring changes in health, economic, and social outcomes.

  14. Discrete-Time Pricing and Optimal Exercise of American Perpetual Warrants in the Geometric Random Walk Model

    Energy Technology Data Exchange (ETDEWEB)

    Vanderbei, Robert J., E-mail: rvdb@princeton.edu [Princeton University, Department of Operations Research and Financial Engineering (United States); P Latin-Small-Letter-Dotless-I nar, Mustafa C., E-mail: mustafap@bilkent.edu.tr [Bilkent University, Department of Industrial Engineering (Turkey); Bozkaya, Efe B. [Sabanc Latin-Small-Letter-Dotless-I University, Faculty of Administrative Sciences (Turkey)

    2013-02-15

    An American option (or, warrant) is the right, but not the obligation, to purchase or sell an underlying equity at any time up to a predetermined expiration date for a predetermined amount. A perpetual American option differs from a plain American option in that it does not expire. In this study, we solve the optimal stopping problem of a perpetual American option (both call and put) in discrete time using linear programming duality. Under the assumption that the underlying stock price follows a discrete time and discrete state Markov process, namely a geometric random walk, we formulate the pricing problem as an infinite dimensional linear programming (LP) problem using the excessive-majorant property of the value function. This formulation allows us to solve complementary slackness conditions in closed-form, revealing an optimal stopping strategy which highlights the set of stock-prices where the option should be exercised. The analysis for the call option reveals that such a critical value exists only in some cases, depending on a combination of state-transition probabilities and the economic discount factor (i.e., the prevailing interest rate) whereas it ceases to be an issue for the put.

  15. 'Thinking ill of others without sufficient warrant?' Transcending the accuracy-inaccuracy dualism in prejudice and stereotyping research.

    Science.gov (United States)

    Dixon, John

    2017-03-01

    Research on prejudice seeks to understand and transform inaccurate beliefs about others. Indeed, historically such research has offered a cautionary tale of the biased nature of human cognition. Recently, however, this view has been challenged by work defending the essential rationality of intergroup perception, a theme captured controversially in Jussim and colleagues' (2009) research on the 'unbearable accuracy of stereotyping'. The present paper argues that in its own terms the 'rationalist turn' in socio-cognitive research on stereotyping presents an important challenge to the prejudice tradition, raising troubling questions about its conceptual and empirical foundations. However, it also argues for the necessity of transcending those terms. By focusing on the correspondence between individual beliefs and the supposedly 'objective' characteristics of others, we neglect the historical and discursive practices through which the social realities that we 'perceive' are actively constructed and institutionalized. We mask their social origins, contested and perspectival nature, relativity, and relationship to wider structures of power. By implication, moving beyond the Allportian perspective that has dominated both the prejudice tradition and the emerging stereotype accuracy paradigm, we may now need to prioritize other kinds of questions. Reversing Allport's famous definition of prejudice, it may now be time to ask: How, and with what consequences, does 'thinking ill of others' become sufficiently warranted? How does such thinking become part of institutionalized relations of power and an accepted way of perceiving, evaluating and treating others? What should social psychologists be doing to challenge this state of affairs? © 2017 The British Psychological Society.

  16. Measuring the Effect of Housing Quality Interventions: The Case of the New Zealand "Rental Warrant of Fitness".

    Science.gov (United States)

    Telfar-Barnard, Lucy; Bennett, Julie; Howden-Chapman, Philippa; Jacobs, David E; Ormandy, David; Cutler-Welsh, Matthew; Preval, Nicholas; Baker, Michael G; Keall, Michael

    2017-11-07

    In New Zealand, as in many other countries, housing in the private-rental sector is in worse condition than in the owner-occupier housing sector. New Zealand residential buildings have no inspection regime after original construction signoff. Laws and regulations mandating standards for existing residential housing are outdated and spread over a range of instruments. Policies to improve standards in existing housing have been notoriously difficult to implement. In this methods paper, we describe the development and implementation of a rental Warrant of Fitness (WoF) intended to address these problems. Dwellings must pass each of 29 criteria for habitability, insulation, heating, ventilation, safety, amenities, and basic structural soundness to reach the WoF minimum standard. The WoF's development was based on two decades of research on the impact of housing quality on health and wellbeing, and strongly influenced by the UK Housing Health and Safety Rating System and US federal government housing standards. Criteria were field-tested across a range of dwelling types and sizes, cities, and climate zones. The implementation stage of our WoF research consists of a non-random controlled quasi-experimental study in which we work with two city-level local government councils to implement the rental WoF, recruiting adjoining council areas as controls, and measuring changes in health, economic, and social outcomes.

  17. Discrete-Time Pricing and Optimal Exercise of American Perpetual Warrants in the Geometric Random Walk Model

    International Nuclear Information System (INIS)

    Vanderbei, Robert J.; Pınar, Mustafa Ç.; Bozkaya, Efe B.

    2013-01-01

    An American option (or, warrant) is the right, but not the obligation, to purchase or sell an underlying equity at any time up to a predetermined expiration date for a predetermined amount. A perpetual American option differs from a plain American option in that it does not expire. In this study, we solve the optimal stopping problem of a perpetual American option (both call and put) in discrete time using linear programming duality. Under the assumption that the underlying stock price follows a discrete time and discrete state Markov process, namely a geometric random walk, we formulate the pricing problem as an infinite dimensional linear programming (LP) problem using the excessive-majorant property of the value function. This formulation allows us to solve complementary slackness conditions in closed-form, revealing an optimal stopping strategy which highlights the set of stock-prices where the option should be exercised. The analysis for the call option reveals that such a critical value exists only in some cases, depending on a combination of state-transition probabilities and the economic discount factor (i.e., the prevailing interest rate) whereas it ceases to be an issue for the put.

  18. High-fertility phenotypes: two outbred mouse models exhibit substantially different molecular and physiological strategies warranting improved fertility.

    Science.gov (United States)

    Langhammer, Martina; Michaelis, Marten; Hoeflich, Andreas; Sobczak, Alexander; Schoen, Jennifer; Weitzel, Joachim M

    2014-01-01

    Animal models are valuable tools in fertility research. Worldwide, there are more than 400 transgenic or knockout mouse models available showing a reproductive phenotype; almost all of them exhibit an infertile or at least subfertile phenotype. By contrast, animal models revealing an improved fertility phenotype are barely described. This article summarizes data on two outbred mouse models exhibiting a 'high-fertility' phenotype. These mouse lines were generated via selection over a time period of more than 40 years and 161 generations. During this selection period, the number of offspring per litter and the total birth weight of the entire litter nearly doubled. Concomitantly with the increased fertility phenotype, several endocrine parameters (e.g. serum testosterone concentrations in male animals), physiological parameters (e.g. body weight, accelerated puberty, and life expectancy), and behavioral parameters (e.g. behavior in an open field and endurance fitness on a treadmill) were altered. We demonstrate that the two independently bred high-fertility mouse lines warranted their improved fertility phenotype using different molecular and physiological strategies. The fertility lines display female- as well as male-specific characteristics. These genetically heterogeneous mouse models provide new insights into molecular and cellular mechanisms that enhance fertility. In view of decreasing fertility in men, these models will therefore be a precious information source for human reproductive medicine. Translated abstract A German translation of abstract is freely available at http://www.reproduction-online.org/content/147/4/427/suppl/DC1.

  19. The Robobo Project: Bringing Educational Robotics Closer to Real-World Applications

    DEFF Research Database (Denmark)

    Bellas, Francisco; Naya, Martin; Varela, Gervasio

    2017-01-01

    The Robobo Project is a STEM-based project that aims to bring educational robotics, in primary and high school, closer to real-world applications. It is based on the use of a smartphone-based robotic platform called Robobo, a very flexible programming environment, and a set of lessons to integrate...... them. The smartphone provides high-level hardware capabilities in terms of sensors, communications and processing capabilities that allow to create more practical and realistic lessons that exploit human-robot interaction, with a small investment. In this paper, we present the main elements...

  20. Moving forward together, stronger, and closer: An interpretative phenomenological analysis of marital benefits in infertile couples.

    Science.gov (United States)

    Sauvé, Marie-Soleil; Péloquin, Katherine; Brassard, Audrey

    2018-03-01

    Some couples find in infertility the bonding opportunities that reinforce their relationship. Using an interpretative phenomenological analysis, this study examined marital benefits in three couples seeking fertility treatment. Interviews revealed five types of benefits: being engaged in a shared hardship, feeling closer to one another, feeling reassured in the relationship, developing a satisfying communication and support behaviors, and having faith in the couple's capacity to face adversity. A dyadic analysis also illustrated how marital benefits developed in each couple. Marital benefits nourished marital satisfaction, thus underscoring their importance to help couples cope through fertility treatment.

  1. A story of scrutiny and fear: Australian midwives' experiences of an external review of obstetric services, being involved with litigation and the impact on clinical practice.

    Science.gov (United States)

    Hood, Laraine; Fenwick, Jennifer; Butt, Janice

    2010-06-01

    to describe Australian midwives' experiences of an external review of obstetric services, involvement in legal proceedings and the impact on midwives' clinical practice and personal wellbeing. the external review process (commonly referred to as the 'Douglas Inquiry') was initiated by a state government and was in response to hospital staff and consumer complaints that focused on anomalies in client care and a significantly high rate of adverse outcomes and clinical errors. It took place within the context of a number of legal proceedings against medical practitioners. As a result, some midwives employed by the hospital were called to give evidence at a variety of legal forums. a qualitative study using an explorative descriptive design. Snowball sampling was used to invite 16 Australian midwives to participate in a tape-recorded interview. Thematic analysis and the techniques associated with constant comparison were used to analyse the data. Australian maternity tertiary referral centre. the analysis identified two overarching themes, 'A story of scrutiny' and 'A story of fear', each with a number of subthemes. 'A story of scrutiny' consists of three subthemes. 'A cloak and dagger affair' reflects the midwives' sense of being and feeling 'exposed' and 'vulnerable' whilst simultaneously being 'kept in the dark' and uninformed during the review process. The subtheme 'Being thrown to the wolves' describes the midwives' experiences of being involved, as witnesses, in medico-legal proceedings. The third subtheme, 'The Inquiry followed them home' outlines the effect on midwives' emotional wellbeing and personal relationships. The second major theme, 'A story of fear' again consists of a number of subthemes. 'Feeling unsafe at work: a culture of fear' describes the midwives' experiences of working within an environment they perceive as driven by the fear of litigation. In order to protect themselves and maintain a sense of control, the midwives adopted a number of

  2. Risk of breast cancer after a diagnosis of ovarian cancer in BRCA mutation carriers: Is preventive mastectomy warranted?

    Science.gov (United States)

    McGee, Jacob; Giannakeas, Vasily; Karlan, Beth; Lubinski, Jan; Gronwald, Jacek; Rosen, Barry; McLaughlin, John; Risch, Harvey; Sun, Ping; Foulkes, William D; Neuhausen, Susan L; Kotsopoulos, Joanne; Narod, Steven A

    2017-05-01

    Preventive breast surgery and MRI screening are offered to unaffected BRCA mutation carriers. The clinical benefit of these two modalities has not been evaluated among mutation carriers with a history of ovarian cancer. Thus, we sought to determine whether or not BRCA mutation carriers with ovarian cancer would benefit from preventive mastectomy or from MRI screening. First, the annual mortality rate for ovarian cancer patients was estimated for a cohort of 178 BRCA mutation carriers from Ontario, Canada. Next, the actuarial risk of developing breast cancer was estimated using an international registry of 509 BRCA mutation carriers with ovarian cancer. A series of simulations was conducted to evaluate the reduction in the probability of death (from all causes) associated with mastectomy and with MRI-based breast surveillance. Cox proportional hazards models were used to evaluate the impacts of mastectomy and MRI screening on breast cancer incidence as well as on all-cause mortality. Twenty (3.9%) of the 509 patients developed breast cancer within ten years following ovarian cancer diagnosis. The actuarial risk of developing breast cancer at ten years post-diagnosis, conditional on survival from ovarian cancer and other causes of mortality was 7.8%. Based on our simulation results, among all BRCA mutation-carrying patients diagnosed with stage III/IV ovarian cancer at age 50, the chance of dying before age 80 was reduced by less than 1% with MRI and by less than 2% with mastectomy. Greater improvements in survival with MRI or mastectomy were observed for women who had already survived 10years after ovarian cancer, and for women with stage I or II ovarian cancer. Among BRCA mutation-carrying ovarian cancer patients without a personal history of breast cancer, neither preventive mastectomy nor MRI screening is warranted, except for those who have survived ovarian cancer without recurrence for ten years and for those with early stage ovarian cancer. Copyright © 2017

  3. Does the health status of intimate partner violence victims warrant pharmacies as portals for public health promotion?

    Science.gov (United States)

    Cerulli, Catherine; Cerulli, Jennifer; Santos, Elizabeth J; Lu, Najii; He, Hua; Kaukeinen, Kimberly; White, Anne Marie; Tu, Xin

    To explore whether the health status of intimate partner violence (IPV) victims warrants pharmacies to be portals for public health promotion. Specific objectives included (1) identifying prevalence of IPV including domestic violence (DV) and sexual assault (SA) in a community sample, (2) describing characteristics and correlates of DV/SA between participants who reported and did not report DV/SA, and (3) exploring whether DV/SA status is related to mental health medication use. Cross sectional. Upstate New York during 2006. English- and Spanish-speaking respondents younger than 65 years of age answering four questions to assess DV/SA. Secondary analysis of a countywide random telephone survey, the 2006 Monroe County Adult Health Survey, which collects prevalence data on health behaviors and health status indicators. To determine whether those reporting DV/SA are at increased odds for mental health medication use, controlling for other sociodemographic- and health-related variables. The survey response rate was 30.3%, with 1,881 respondents meeting inclusion criteria. Those reporting DV/SA were almost twice as likely to use mental health medications. However, when controlling for other variables, only poor mental and physical health were significant in increasing the odds of mental health medication use. The analyses reported here suggest that DV/SA victims in a community sample use mental health medications. When controlling for other variables, survey respondents reported worse physical and mental health. If pharmacies are suitable portals for DV/SA outreach, curricula would need to provide the knowledge and skills needed to take an active role in this public health promotion.

  4. Is a comparative clinical trial for breast cancer tumor markers to monitor disease recurrence warranted? A value of information analysis.

    Science.gov (United States)

    Thariani, Rahber; Henry, Norah Lynn; Ramsey, Scott D; Blough, David K; Barlow, Bill; Gralow, Julie R; Veenstra, David L

    2013-05-01

    Breast cancer tumor markers are used by some clinicians to screen for disease recurrence risk. Since there is limited evidence of benefit, additional research may be warranted. To assess the potential value of a randomized clinical trial of breast tumor marker testing in routine follow-up of high-risk, stage II-III breast cancer survivors. We developed a decision-analytic model of tumor marker testing plus standard surveillance every 3-6 months for 5 years. The expected value of sample information was calculated using probabilistic simulations and was a function of: the probability of selecting the optimal monitoring strategy with current versus future information; the impact of choosing the nonoptimal strategy; and the size of the population affected. The value of information for a randomized clinical trial involving 9000 women was US$214 million compared with a cost of US$30-60 million to conduct such a trial. The probability of making an alternate, nonoptimal decision and choosing testing versus no testing was 32% with current versus future information from the trial. The impact of a nonoptimal decision was US$2150 and size of population impacted over 10 years was 308,000. The value of improved information on overall survival was US$105 million, quality of life US$37 million and test performance US$71 million. Conducting a randomized clinical trial of breast cancer tumor markers appears to offer a good societal return on investment. Retrospective analyses to assess test performance and evaluation of patient quality of life using tumor markers may also offer valuable areas of research. However, alternative investments may offer even better returns in investments and, as such, the trial concept deserves further study as part of an overall research-portfolio evaluation.

  5. West Nile Virus: High Transmission Rate in North-Western European Mosquitoes Indicates Its Epidemic Potential and Warrants Increased Surveillance.

    Directory of Open Access Journals (Sweden)

    Jelke J Fros

    Full Text Available West Nile virus (WNV is a highly pathogenic flavivirus transmitted by Culex spp. mosquitoes. In North America (NA, lineage 1 WNV caused the largest outbreak of neuroinvasive disease to date, while a novel pathogenic lineage 2 strain circulates in southern Europe. To estimate WNV lineage 2 epidemic potential it is paramount to know if mosquitoes from currently WNV-free areas can support further spread of this epidemic.We assessed WNV vector competence of Culex pipiens mosquitoes originating from north-western Europe (NWE in direct comparison with those from NA. We exposed mosquitoes to infectious blood meals of lineage 1 or 2 WNV and determined the infection and transmission rates. We explored reasons for vector competence differences by comparing intrathoracic injection versus blood meal infection, and we investigated the influence of temperature. We found that NWE mosquitoes are highly competent for both WNV lineages, with transmission rates up to 25%. Compared to NA mosquitoes, transmission rates for lineage 2 WNV were significantly elevated in NWE mosquitoes due to better virus dissemination from the midgut and a shorter extrinsic incubation time. WNV infection rates further increased with temperature increase.Our study provides experimental evidence to indicate markedly different risk levels between both continents for lineage 2 WNV transmission and suggests a degree of genotype-genotype specificity in the interaction between virus and vector. Our experiments with varying temperatures explain the current localized WNV activity in southern Europe, yet imply further epidemic spread throughout NWE during periods with favourable climatic conditions. This emphasizes the need for intensified surveillance of virus activity in current WNV disease-free regions and warrants increased awareness in clinics throughout Europe.

  6. The Commonwealth Games as an Example of Bringing States Closer Through Sport

    Directory of Open Access Journals (Sweden)

    Kobierecki Michał Marcin

    2017-03-01

    Full Text Available The aim of the article is to investigate the issue of positive sports diplomacy directed at bringing countries closer and deepening cooperation between them. Generally, sports diplomacy is a broader term and may include various ways of utilizing sport, both negative and positive, even for the sake of nation-branding. Positive sports diplomacy most commonly refers to bringing hostile states closer together, but it may also be used to deepen political alliances or foster friendship and cooperation between states that are not mutually hostile. The research focuses on the latter form of positive sports diplomacy. The investigation is a case study concerning the Commonwealth Games, a sports event that is held once every four years and gathers countries and territories that used to belong to the former British Empire. The research therefore aims to determine whether this event, the second largest multisport event in the world, is significant from political and diplomatic perspectives. A second research question concerns whether the Commonwealth Games should be seen as an attempt by Great Britain to maintain influence in its former colonies. The research attempts to test the hypothesis that the Commonwealth Games are an important contributor to sustaining ties between states of the former British Empire.

  7. The closer the relationship, the more the interaction on facebook? Investigating the case of Taiwan users.

    Science.gov (United States)

    Hsu, Chiung-Wen Julia; Wang, Ching-Chan; Tai, Yi-Ting

    2011-01-01

    This study argues for the necessity of applying offline contexts to social networking site research and the importance of distinguishing the relationship types of users' counterparts when studying Facebook users' behaviors. In an attempt to examine the relationship among users' behaviors, their counterparts' relationship types, and the users' perceived acquaintanceships after using Facebook, this study first investigated users' frequently used tools when interacting with different types of friends. Users tended to use less time- and effort-consuming and less privacy-concerned tools with newly acquired friends. This study further examined users' behaviors in terms of their closeness and intimacy and their perceived acquaintanceships toward four different types of friends. The study found that users gained more perceived acquaintanceships from less close friends with whom users have more frequent interaction but less intimate behaviors. As for closer friends, users tended to use more intimate activities to interact with them. However, these activities did not necessarily occur more frequently than the activities they employed with their less close friends. It was found that perceived acquaintanceships with closer friends were significantly lower than those with less close friends. This implies that Facebook is a mechanism for new friends, rather than close friends, to become more acquainted.

  8. It’s not the Fish that Stinks! EU Trade Relations with Morocco under the Scrutiny of the General Court of the European Union

    Directory of Open Access Journals (Sweden)

    Sandra Hummelbrunner

    2016-09-01

    Full Text Available The EU’s international agreements with Morocco on trade in agricultural and fishery products have drawn criticism due to their application to the disputed territory of Western Sahara, a territory that remains on the list of non-self-governing territories to be decolonised in accordance with the right of self-determination of the indigenous Sahrawi people. Recently, the Sahrawi liberation movement Front Polisario brought an action for annulment before the General Court of the European Union (GC against the Council Decision approving the conclusion of one such agreement, alleging multiple violations of European and international legal norms. Interestingly, although the GC concurred by annulling the Decision insofar as it applies to Western Sahara, it chose to exclusively base its judgment on EU fundamental rights, invoking the EU’s failure to ensure that the fundamental rights of the Sahrawi people were not infringed by applying the agreements to Western Sahara. By summarily setting aside Front Polisario’s other claims, several relevant questions of applicable international and European law, which warrant further discussion, remain. This article examines these questions using the GC’s judgment in Front Polisario, thereby combining general matters of international and European law with the specific circumstances of the EU-Morocco relations and Western Sahara.

  9. 'The Closer'-percutaneous vascular suture device: evaluation of safety and performance in neuroangiography

    International Nuclear Information System (INIS)

    Henk, Christine B.; Grampp, Stephan; Heimberger, Karl; Czerny, Christian; Schindler, Erwin; Mostbeck, Gerhard H.

    2003-01-01

    Objective: To evaluate the use of the suture mediated vascular closure device concerning practicability and safety in clinical angiography practice. Material and methods: One hundred and seventeen patients (59 female, 58 male, mean age 40.9±13.4) underwent percutaneous closure of common femoral arterial puncture sites following diagnostic neuroangiography using the suture device 'the Closer' (Perclose Inc., Redwood City, CA, USA). Primary success, early problems (within 24 h) and late complications were evaluated. Complications were graded as minor and severe with or without need of surgical intervention and categorized by type. Parameters such as age, gender, sheath size and number of previous arterial punctures were evaluated with respect to complications. Results: Percutaneous closure was primary successful in 85% (100/117). The overall complication rate was 32% (28% mild n=35, 4% severe n=6, which needed surgical intervention). All but one problem occurred within the first 24 h after the suture. Additional manual compression was necessary in 32 cases (25%). There was no significant difference in age and gender between the groups with and without complications. Sheath size was significantly larger (P<0.01) and numbers of preceding angiograms were significantly higher (P<0.01) in the complications group compared with uncomplicated cases. Conclusion: The evaluated percutaneous vascular suture device is useful in clinical practice but limitations concerning patient selection seem to emerge in order to avoid complications

  10. A Snapshot of Gender in Brazil Today : Institutions, Outcomes, and a Closer Look at Racial and Geographic Differences

    OpenAIRE

    Gukovas, Renata; Muller, Miriam; Pereira, Ana Claudia; Reimao, Maira Emy

    2016-01-01

    The Gender Diagnostic: ‘A Snapshot of Gender in Brazil Today: Institutions, Outcomes, and a Closer Look at Racial and Geographic Differences Gender issues in Brazil’ highlights progress on gender equality in the country and lays out the main areas of persisting challenges. It details gender outcomes beyond the national aggregate and emphasizes that gender inequality in Brazil has to be und...

  11. Warrant Officer Examinations. PR-4018

    Science.gov (United States)

    1944-10-10

    ccouunting, Administrative - Clcorica1, Judge, Advo Ge~nc. De~ptsAdxiiniistrati~ve 1 icl Adi isrtv - Supp:ly, generaile8 ~ Administrativo ’ - Supply, Air...chronological index if action in processing special and summary records of trial. Answers teleph.’nic inquirie’s pertaining to subject matter contain- ed...reproduction by lithopraphy, black and white process printing, and gelatin duplication; moy couidinnte and supervise procurement, storage, and distribution of

  12. GENERAL PRINCIPLES OF EU (CRIMINAL LAW: LEGALITY, EQUALITY, NON-DISCRIMINATION, SPECIALTY AND NE BIS IN IDEM IN THE FIELD OF THE EUROPEAN ARREST WARRANT

    Directory of Open Access Journals (Sweden)

    NOREL NEAGU

    2012-05-01

    Full Text Available This article deals with the case law of the Court of Justice of the European Union in the field of the European arrest warrant, critically analysing the principles invoked in several decisions validating the European legislation in the field: legality, equality and non-discrimination, specialty, ne bis in idem. The author concludes that an area of freedom, security and justice could be built on these principles, but further harmonisation of legislation needs to be realised to avoid a ”journey to the unknown” for European citizens in respect to legislation of other member states of the EU.

  13. SMARTPHONE-BASED DILATED FUNDUS PHOTOGRAPHY AND NEAR VISUAL ACUITY TESTING AS INEXPENSIVE SCREENING TOOLS TO DETECT REFERRAL WARRANTED DIABETIC EYE DISEASE.

    Science.gov (United States)

    Toy, Brian C; Myung, David J; He, Lingmin; Pan, Carolyn K; Chang, Robert T; Polkinhorne, Alison; Merrell, Douglas; Foster, Doug; Blumenkranz, Mark S

    2016-05-01

    To compare clinical assessment of diabetic eye disease by standard dilated examination with data gathered using a smartphone-based store-and-forward teleophthalmology platform. 100 eyes of 50 adult patients with diabetes from a health care safety-net ophthalmology clinic. All patients underwent comprehensive ophthalmic examination. Concurrently, a smartphone was used to estimate near visual acuity and capture anterior and dilated posterior segment photographs, which underwent masked, standardized review. Quantitative comparison of clinic and smartphone-based data using descriptive, kappa, Bland-Altman, and receiver operating characteristic analyses was performed. Smartphone visual acuity was successfully measured in all eyes. Anterior and posterior segment photography was of sufficient quality to grade in 96 and 98 eyes, respectively. There was good correlation between clinical Snellen and smartphone visual acuity measurements (rho = 0.91). Smartphone-acquired fundus photographs demonstrated 91% sensitivity and 99% specificity to detect moderate nonproliferative and worse diabetic retinopathy, with good agreement between clinic and photograph grades (kappa = 0.91 ± 0.1, P smartphone-based telemedicine system that demonstrated sensitivity and specificity to detect referral-warranted diabetic eye disease as a proof-of-concept. Additional studies are warranted to evaluate this approach to expanding screening for diabetic retinopathy.

  14. Matter of 381 Search Warrants Directed to Facebook, 2017 N.Y. Lexis 767, 2; 2017 NY Slip op. 02586, 2 (N.Y. April 4, 2017

    Directory of Open Access Journals (Sweden)

    Trad. Leopoldo Villar

    2017-08-01

    Full Text Available The growing importance of electronic communications gives a special interest to its protection, which involves several fundamental rights and guarantees such as freedom, privacy and property. Due to the importance of the discussion and the different positions it reflects on an issue of such sensitivity and pertinence in the world today, we publish below the translation of the decision by the Supreme Court of the State of New York of April 4, 2017, on the 381 search warrants directed to Facebook user accounts, ordered by the same Court in 2013 in response to a request by the New York County District Attorney, supported in turn by an affidavit given by a prosecutor in a criminal investigation. Facebook filed a motion seeking annulment of the search warrants and disclosure of the Prosecutor’s affidavit but both motions were rejected by the Appeals Division, whereupon Facebook appealed to the New York Supreme Court, which dismissed the appeal. Although most agreed that the appeal was not appropriate, the views of the judges contain interpretations that make their reading very useful and particularly the opinión given by the dissenting judge offers enriching arguments for defending the rights of users of electronic services.

  15. Security Sector Reform and the Serbian Conundrum: Are Security Sector Reform Efforts Bringing Serbia Closer to European Union and North Atlantic Treaty Organization Integration

    National Research Council Canada - National Science Library

    Lewis, Marion J

    2005-01-01

    .... In 2005, certain of the southern Slav nations have gained NATO and EU membership, as in the case of Slovenia, or have drawn ever closer to qualifying for membership, as in the case of Croatia and Bulgaria...

  16. The European Arrest Warrant in the Italian legal system. Between mutual recognition and mutual fear within the European area of Freedom, Security and Justice

    Directory of Open Access Journals (Sweden)

    Franco Impalà

    2005-12-01

    Full Text Available Italy was the last Member State to transpose the Framework Decision on the European Arrest Warrant. The Italian law entered into full force on 14 May 2005, a full sixteen months later than the appointed date. Conversely, whilst the Framework Decision aimed to speed up extradition between Member States, the Italian implementation law seems to complicate things, providing for dozens of new legal obstacles to surrender. In fact, the execution of an EAW in Italy threatens to become something highly unpredictable. The responsibility for this outcome is shared by the national and the European legislator. Perhaps the latter underestimated the seriousness of the conflict between Third Pillar law and domestic constitutional systems which aim to protect their acquis in the field of fundamental rights. Considering that many Member States seem to be struggling with similar problems, the first part of this article is devoted to describing the current scenario and analysing possible solutions at the supranational level, such as the establishment of a coherent system regulating the allocation of penal competences among Member States. In the next part, the problem of the Framework Decision’s incompatibility with the Italian Constitution will be discussed, and in the final part the Italian implementation law is analysed in more detail.

  17. LA Scrutiny in Iranians in England.

    Science.gov (United States)

    Shariati, Mohammad

    2003-01-01

    Presents three major types of language awareness elicited during a pilot study, using data collection instruments, such as interviews and tape recordings of the conversations of two groups of Iranian children living in the United Kingdom. (Author/VWL)

  18. After "Fisher": Academic Review and Judicial Scrutiny

    Science.gov (United States)

    La Noue, George R.

    2013-01-01

    This article describes the outcomes of the case "Fisher v. University of Texas at Austin," in which the plaintiff had accused the University of Texas (UT) of racial discrimination in the admission process. The author believes that the ruling of the court in this case makes it harder to hide race-based measures used in college admissions.…

  19. External costs of electricity production under scrutiny

    International Nuclear Information System (INIS)

    Wagner, H.J.; Melchert, A.

    1993-01-01

    After a short introduction into the problems and questions surrounding the issue of external costs Chapter 2 presents the most important results of the studies under review and analysis in this work. Occasionally, minor discrepancies were found between the results given in the summary of a study and the data reported in the relevant chapters. Chapter 3 identifies and discusses differences in perspective between the studies under consideration. Chapter 4 analyses the most important premises and parameters adopted in the studies for the calculation of overall costs and net benefits of the different modes of electricity production. This serves to probe the reliability of the data, plausibility of the premises, and nature of the presupposed relationships. Chapter 5 examines the relationships of time assumed in the studies and gives a first comment on the more advanced Prognos study. Chapter 6, finally, offers a summarizing evaluation. (orig./UA) [de

  20. HiRadMat: materials under scrutiny

    CERN Multimedia

    Anaïs Schaeffer

    2011-01-01

    CERN's new facility, HiRadMat (High Radiation to Materials), which is designed to test materials for the world's future particle accelerators, should be operational and welcoming its first experiments by the end of the year.   The HiRadMat facility, located in the TNC tunnel. The materials used in the LHC and its experiments are exposed to very high-energy particles. The LHC machine experts obviously didn't wait for the first collisions in the world's most powerful accelerator to put the materials through their paces - the equipment was validated following a series of stringent tests. And these tests will get even tougher now, with the arrival of HiRadMat. The tunnel that formerly housed the West Area Neutrino Facility (WANF) has been completely revamped to make way for CERN's latest facility, HiRadMat. Supported by the Radioprotection service, a team from the Engineering (EN) Department handled the dismantling operations from October 2009 to December 2010. "We could only work on disman...

  1. Windscale: a case study in public scrutiny

    International Nuclear Information System (INIS)

    Bugler, J.

    1978-01-01

    An account is given of the action in Parliament - and relevant action outside Parliament - leading to the setting up of a public inquiry into the application by British Nuclear Fuels Limited for planning permission to construct a thermal oxide reprocessing plant at their Windscale works. The hearings and the subsequent report by the inspector are also examined from the points of view of public involvement and parliamentary and government machinery. (U.K.)

  2. Composite Higgs under LHC Experimental Scrutiny

    Directory of Open Access Journals (Sweden)

    Mühlleitner M.

    2012-06-01

    Full Text Available The LHC has been built to understand the dynamics at the origin of the breaking of the electroweak symmetry. Weakly coupled models with a fundamental Higgs boson have focused most of the attention of the experimental searches. We will discuss here how to reinterpret these searches in the context of strongly coupled models where the Higgs boson emerges as a composite particle. In particular, we use LHC data to constrain the compositeness scale. We also briefly review the prospects to observe other bosonic and fermionic resonances of the strong sector.

  3. Closer to Nature?

    DEFF Research Database (Denmark)

    Borkfelt, Sune; Kondrup, Sara; Röcklinsberg, Helena

    2015-01-01

    discourses in order to sell one image of animal welfare in intensive animal production while the actual production at the same time presupposes a quite different paradigm of animal welfare. Specifically, product advertising utilizes representations tied to concepts of naturalness in depictions of both animal...... lives and product processes as “natural”. Product marketing suggests a coherence between nature, production process (farm, animal), and end product, thereby creating associations that the lives of production animals are lived in nature and that their products bring a wholesome and sustainable...

  4. Closer to Nature?

    DEFF Research Database (Denmark)

    Borkfelt, Sune; Kondrup, Sara; Röcklinsberg, Helena

    2015-01-01

    As public awareness of environmental issues and animal welfare has risen, catering to public concerns and views on these issues has become a potentially profitable strategy for marketing a number of product types, of which animal products such as dairy and meat are obvious examples. Our analysis ...... product marketing, discusses the ethical implications of this type of marketing communication, and stresses the need for transparency in the area of animal welfare....

  5. A need for closer examination of FASD by the criminal justice system: has the call been answered?

    Science.gov (United States)

    Gagnier, Karina Royer; Moore, Timothy E; Green, Melvyn

    2011-01-01

    Individuals with FASD exhibit deficits in many domains that can include memory, learning, behavioural inhibition, executive functioning, interpersonal skills, and language. These deficits have serious implications for affected persons when they become engaged in the legal system. In 2004, Moore and Green reviewed case law and psychological literature which suggested that FASD-related deficits placed affected individuals at a significant disadvantage in the justice system. According to them, this disadvantage stemmed from the limited awareness and knowledge of FASD demonstrated by key players in the justice system, as well as the scarcity of effective interventions in place to rehabilitate affected defendants. The aim of the current paper is to assess the extent to which awareness of FASD-related issues in the Canadian justice system has advanced since the publication of Moore and Green's conclusions. First, the deficits associated with FASD and their implications for the justice system are described. Next, recent case law and psychological evidence are reviewed as we consider issues of witness reliability and false confessions. The significance of FASD for sentencing, fitness to stand trial, and the Not Criminally Responsible by Reason of Mental Disorder defence are also briefly discussed. Finally, emerging system wide responses to FASD-related issues are presented. Overall, it appears that the call for closer examination of FASD by the justice system has been answered, but a need for increased education and awareness remains.

  6. Predictors for the development of referral-warranted retinopathy of prematurity in the telemedicine approaches to evaluating acute-phase retinopathy of prematurity (e-ROP) study.

    Science.gov (United States)

    Ying, Gui-Shuang; Quinn, Graham E; Wade, Kelly C; Repka, Michael X; Baumritter, Agnieshka; Daniel, Ebenezer

    2015-03-01

    Detection of treatment-requiring retinopathy of prematurity (ROP) involves serial eye examinations. An ROP prediction model using predictive factors could identify high-risk infants and reduce required eye examinations. To determine predictive factors for the development of referral-warranted (RW) ROP. This multicenter observational cohort study included secondary analysis of data from the Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity Study. Infants included in the study had a birth weight (BW) of less than 1251 g. Serial ROP examinations of premature infants who had 2 or more ROP examinations. Incidence of RW-ROP (defined as the presence of plus disease, zone I ROP, or ROP stage 3 or greater in either eye) and associations with predictive factors. Among 979 infants without RW-ROP at first study-related eye examination (median postmenstrual age, 33 weeks; range, 29-40 weeks) who underwent at least 2 eye examinations, 149 (15.2%) developed RW-ROP. In a multivariate model, significant predictors for RW-ROP were male sex (odds ratio [OR], 1.80; 95% CI, 1.13-2.86 vs female), nonblack race (OR, 2.76; 95% CI, 1.50-5.08 for white vs black race and OR, 4.81; 95% CI, 2.19-10.6 for other vs black race), low BW (OR, 5.16; 95% CI, 1.12-7.20 for ≤500 g vs >1100 g), younger gestational age (OR, 9.79; 95% CI, 3.49-27.5 for ≤24 weeks vs ≥28 weeks), number of quadrants with preplus disease (OR, 7.12; 95% CI, 2.53-20.1 for 1-2 quadrants and OR, 18.4; 95% CI, 4.28-79.4 for 3-4 quadrants vs no preplus disease), stage 2 ROP (OR, 4.13; 95% CI, 2.13-8.00 vs no ROP), the presence of retinal hemorrhage (OR, 4.36; 95% CI, 1.57-12.1 vs absence), the need for respiratory support (OR, 4.99; 95% CI, 1.89-13.2 for the need for controlled mechanical ventilator; OR, 11.0; 95% CI, 2.26-53.8 for the need for high-frequency oscillatory ventilation vs no respiratory support), and slow weight gain (OR, 2.44; 95% CI, 1.22-4.89 for weight gain ≤12 g/d vs >18 g

  7. Ahead of snap elections, Greenland’s independence ambitions could open a window for closer co-operation with the EU

    DEFF Research Database (Denmark)

    Gad, Ulrik Pram

    2014-01-01

    turmoil has undermined plans to use investment in extractive industries such as mining as the basis for an independent economy. He argues that the situation could present an opportunity for the EU to engage in closer bilateral co-operation with the country, particularly given Greenland’s natural resources...

  8. Ex Vivo and In Vivo Mice Models to Study Blastocystis spp. Adhesion, Colonization and Pathology: Closer to Proving Koch's Postulates.

    Directory of Open Access Journals (Sweden)

    Sitara S R Ajjampur

    Full Text Available Blastocystis spp. are widely prevalent extra cellular, non-motile anerobic protists that inhabit the gastrointestinal tract. Although Blastocystis spp. have been associated with gastrointestinal symptoms, irritable bowel syndrome and urticaria, their clinical significance has remained controversial. We established an ex vivo mouse explant model to characterize adhesion in the context of tissue architecture and presence of the mucin layer. Using confocal microscopy with tissue whole mounts and two axenic isolates of Blastocystis spp., subtype 7 with notable differences in adhesion to intestinal epithelial cells (IEC, isolate B (ST7-B and isolate H (more adhesive, ST7-H, we showed that adhesion is both isolate dependent and tissue trophic. The more adhesive isolate, ST7-H was found to bind preferentially to the colon tissue than caecum and terminal ileum. Both isolates were also found to have mucinolytic effects. We then adapted a DSS colitis mouse model as a susceptible model to study colonization and acute infection by intra-caecal inoculation of trophic Blastocystis spp.cells. We found that the more adhesive isolate ST7-H was also a better colonizer with more mice shedding parasites and for a longer duration than ST7-B. Adhesion and colonization was also associated with increased virulence as ST7-H infected mice showed greater tissue damage than ST7-B. Both the ex vivo and in vivo models used in this study showed that Blastocystis spp. remain luminal and predominantly associated with mucin. This was further confirmed using colonic loop experiments. We were also successfully able to re-infect a second batch of mice with ST7-H isolates obtained from fecal cultures and demonstrated similar histopathological findings and tissue damage thereby coming closer to proving Koch's postulates for this parasite.

  9. The change in capacity and service delivery at public and private hospitals in Turkey: a closer look at regional differences.

    Science.gov (United States)

    Aksan, Hediye A D; Ergin, Işıl; Ocek, Zeliha

    2010-11-01

    Substantial regional health inequalities have been shown to exist in Turkey for major health indicators. Turkish data on hospitals deserves a closer examination with a special emphasis on the regional differences in the context of the rapid privatization of the secondary or tertiary level health services.This study aims to evaluate the change in capacity and service delivery at public and private hospitals in Turkey between 2001-2006 and to determine the regional differences. Data for this retrospective study was provided from Statistical Almanacs of Inpatient Services (2001-2006). Hospitals in each of the 81 provinces were grouped into two categories: public and private. Provinces were grouped into six regions according to a development index composed by the State Planning Organisation. The number of facilities, hospital beds, outpatient admissions, inpatient admissions (per 100 000), number of deliveries and surgical operations (per 10 000) were calculated for public and private hospitals in each province and region. Regional comparisons were based on calculation of ratios for Region 1(R1) to Region 6(R6). Public facilities had a fundamental role in service delivery. However, private sector grew rapidly in Turkey between 2001-2006 in capacity and service delivery. In public sector, there were 2.3 fold increase in the number of beds in R1 to R6 in 2001. This ratio was 69.9 fold for private sector. The substantial regional inequalities in public and private sector decreased for the private sector enormously while a little decrease was observed for the public sector. In 2001 in R1, big surgical operations were performed six times more than R6 at the public sector whereas the difference was 117.7 fold for the same operations in the same regions for the private sector. These ratios decreased to 3.6 for the public sector and 13.9 for the private sector in 2006. The private health sector has grown enormously between 2001-2006 in Turkey including the less developed

  10. The change in capacity and service delivery at public and private hospitals in Turkey: A closer look at regional differences

    Directory of Open Access Journals (Sweden)

    Ergin Işıl

    2010-11-01

    Full Text Available Abstract Background Substantial regional health inequalities have been shown to exist in Turkey for major health indicators. Turkish data on hospitals deserves a closer examination with a special emphasis on the regional differences in the context of the rapid privatization of the secondary or tertiary level health services. This study aims to evaluate the change in capacity and service delivery at public and private hospitals in Turkey between 2001-2006 and to determine the regional differences. Methods Data for this retrospective study was provided from Statistical Almanacs of Inpatient Services (2001-2006. Hospitals in each of the 81 provinces were grouped into two categories: public and private. Provinces were grouped into six regions according to a development index composed by the State Planning Organisation. The number of facilities, hospital beds, outpatient admissions, inpatient admissions (per 100 000, number of deliveries and surgical operations (per 10 000 were calculated for public and private hospitals in each province and region. Regional comparisons were based on calculation of ratios for Region 1(R1 to Region 6(R6. Results Public facilities had a fundamental role in service delivery. However, private sector grew rapidly in Turkey between 2001-2006 in capacity and service delivery. In public sector, there were 2.3 fold increase in the number of beds in R1 to R6 in 2001. This ratio was 69.9 fold for private sector. The substantial regional inequalities in public and private sector decreased for the private sector enormously while a little decrease was observed for the public sector. In 2001 in R1, big surgical operations were performed six times more than R6 at the public sector whereas the difference was 117.7 fold for the same operations in the same regions for the private sector. These ratios decreased to 3.6 for the public sector and 13.9 for the private sector in 2006. Conclusions The private health sector has grown

  11. EURATOM research and training programme: towards a new way of developing-teaching science, closer to the end-users

    International Nuclear Information System (INIS)

    Van Goethem, G.

    2015-01-01

    important is public information and engagement in energy policy issues, notably in connection with nuclear decision making. In fact, a new way of 'developing - teaching science' is emerging in the EU, closer to the needs of the end-users, i.e.: society and industry. As a result, a strong scientific foundation is being established to support decision making in regulatory and/or industrial organisations, based on confirmed facts and research findings stemming from 'Best Available Science'. The article is followed by the slides of the presentation

  12. Use of social network sites and instant messaging does not lead to increased offline social network size, or to emotionally closer relationships with offline network members.

    Science.gov (United States)

    Pollet, Thomas V; Roberts, Sam G B; Dunbar, Robin I M

    2011-04-01

    The effect of Internet use on social relationships is still a matter of intense debate. This study examined the relationships between use of social media (instant messaging and social network sites), network size, and emotional closeness in a sample of 117 individuals aged 18 to 63 years old. Time spent using social media was associated with a larger number of online social network "friends." However, time spent using social media was not associated with larger offline networks, or feeling emotionally closer to offline network members. Further, those that used social media, as compared to non-users of social media, did not have larger offline networks, and were not emotionally closer to offline network members. These results highlight the importance of considering potential time and cognitive constraints on offline social networks when examining the impact of social media use on social relationships.

  13. Using the 2011 Mw9.0 Tohoku earthquake to test the Coulomb stress triggering hypothesis and to calculate faults brought closer to failure

    Science.gov (United States)

    Toda, Shinji; Lin, Jian; Stein, Ross S.

    2011-01-01

    The 11 March 2011 Tohoku Earthquake provides an unprecedented test of the extent to which Coulomb stress transfer governs the triggering of aftershocks. During 11-31 March, there were 177 aftershocks with focal mechanisms, and so the Coulomb stress change imparted by the rupture can be resolved on the aftershock nodal planes to learn whether they were brought closer to failure. Numerous source models for the mainshock have been inverted from seismic, geodetic, and tsunami observations. Here, we show that, among six tested source models, there is a mean 47% gain in positively-stressed aftershock mechanisms over that for the background (1997-10 March 2011) earthquakes, which serve as the control group. An aftershock fault friction of 0.4 is found to fit the data better than 0.0 or 0.8, and among all the tested models, Wei and Sladen (2011) produced the largest gain, 63%. We also calculate that at least 5 of the seven large, exotic, or remote aftershocks were brought ≥0.3 bars closer to failure. With these tests as confirmation, we calculate that large sections of the Japan trench megathrust, the outer trench slope normal faults, the Kanto fragment beneath Tokyo, and the Itoigawa-Shizuoka Tectonic Line, were also brought ≥0.3 bars closer to failure.

  14. The nuclear pacemaker: Is renewed interest warranted

    International Nuclear Information System (INIS)

    Parsonnet, V.; Berstein, A.D.; Perry, G.Y.

    1990-01-01

    From 1973 through 1987, 155 radioisotope-powered nuclear pacemakers were implanted in 132 patients at the Newark Beth Israel Medical Center. The longevity of the first 15 devices, all of which were fixed-rate (VOO) pacemakers, was significantly better than that of 15 lithium-chemistry demand (VVI) pacemakers used as control devices (p = 0.0002). Of the entire cohort of 155 nuclear pacemakers, 136 were VVI devices and 19 were VOO units. The patients with VOO pacemakers needed reoperations more often than did those with VVI pacemakers, chiefly for mode change (p less than 0.001). Power-source failure was observed in only 1 case, but 47 nuclear pacemakers were removed for other reasons, including component malfunction (15 units), mode change (12 units), high pacing thresholds (8 units) and lead or connector problems (5 units). The actuarial survival at 15 years was 99% for power sources and 82% for the entire pacing systems (pulse generators plus leads). The frequency of malignancy was similar to that of the population at large and primary tumor sites were randomly distributed. Deaths most commonly were due to cardiac causes (68%). Thus, nuclear pacemakers are safe and reliable and their greater initial cost appears to be offset by their longevity and the resulting decrease in the frequency of reoperations. It is reasonable to suggest that further use be made of long-lasting nuclear power sources for modern pacemakers and other implantable rhythm-management devices

  15. Measuring Distribution Performance? Benchmarking Warrants Your Attention

    Energy Technology Data Exchange (ETDEWEB)

    Ericson, Sean J [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Alvarez, Paul [The Wired Group

    2018-04-13

    Identifying, designing, and measuring performance metrics is critical to securing customer value, but can be a difficult task. This article examines the use of benchmarks based on publicly available performance data to set challenging, yet fair, metrics and targets.

  16. Bioactive endophytes warrant intensified exploration and conservation.

    Science.gov (United States)

    Smith, Stephen A; Tank, David C; Boulanger, Lori-Ann; Bascom-Slack, Carol A; Eisenman, Kaury; Kingery, David; Babbs, Beatrice; Fenn, Kathleen; Greene, Joshua S; Hann, Bradley D; Keehner, Jocelyn; Kelley-Swift, Elizabeth G; Kembaiyan, Vivek; Lee, Sun Jin; Li, Puyao; Light, David Y; Lin, Emily H; Ma, Cong; Moore, Emily; Schorn, Michelle A; Vekhter, Daniel; Nunez, Percy V; Strobel, Gary A; Donoghue, Michael J; Strobel, Scott A

    2008-08-25

    A key argument in favor of conserving biodiversity is that as yet undiscovered biodiversity will yield products of great use to humans. However, the link between undiscovered biodiversity and useful products is largely conjectural. Here we provide direct evidence from bioassays of endophytes isolated from tropical plants and bioinformatic analyses that novel biology will indeed yield novel chemistry of potential value. We isolated and cultured 135 endophytic fungi and bacteria from plants collected in Peru. nrDNAs were compared to samples deposited in GenBank to ascertain the genetic novelty of cultured specimens. Ten endophytes were found to be as much as 15-30% different than any sequence in GenBank. Phylogenetic trees, using the most similar sequences in GenBank, were constructed for each endophyte to measure phylogenetic distance. Assays were also conducted on each cultured endophyte to record bioactivity, of which 65 were found to be bioactive. The novelty of our contribution is that we have combined bioinformatic analyses that document the diversity found in environmental samples with culturing and bioassays. These results highlight the hidden hyperdiversity of endophytic fungi and the urgent need to explore and conserve hidden microbial diversity. This study also showcases how undergraduate students can obtain data of great scientific significance.

  17. Bioactive endophytes warrant intensified exploration and conservation.

    Directory of Open Access Journals (Sweden)

    Stephen A Smith

    2008-08-01

    Full Text Available A key argument in favor of conserving biodiversity is that as yet undiscovered biodiversity will yield products of great use to humans. However, the link between undiscovered biodiversity and useful products is largely conjectural. Here we provide direct evidence from bioassays of endophytes isolated from tropical plants and bioinformatic analyses that novel biology will indeed yield novel chemistry of potential value.We isolated and cultured 135 endophytic fungi and bacteria from plants collected in Peru. nrDNAs were compared to samples deposited in GenBank to ascertain the genetic novelty of cultured specimens. Ten endophytes were found to be as much as 15-30% different than any sequence in GenBank. Phylogenetic trees, using the most similar sequences in GenBank, were constructed for each endophyte to measure phylogenetic distance. Assays were also conducted on each cultured endophyte to record bioactivity, of which 65 were found to be bioactive.The novelty of our contribution is that we have combined bioinformatic analyses that document the diversity found in environmental samples with culturing and bioassays. These results highlight the hidden hyperdiversity of endophytic fungi and the urgent need to explore and conserve hidden microbial diversity. This study also showcases how undergraduate students can obtain data of great scientific significance.

  18. Greenhouse gas reductions; not warranted, not beneficial

    International Nuclear Information System (INIS)

    Green, K.

    2003-01-01

    This report deals with climate change and greenhouse gas emissions, especially regional climate change predictions, from a sceptic's point of view. It rejects all the conventional evidence supporting claims of extreme man-made climate changes, dismissing them as alarmist and inherently uncertain. Similarly, it characterizes policy prescriptions based on this evidence as faulty and as measures which, if implemented, would do both current and future generations considerably more harm than good. Calls for energy efficiency and conservation, reliance on renewable energy sources, improved efficiency of conventional vehicles, hybrid and fuel-cell-driven cars, reducing the amount of driving, establishing greenhouse gas registries, are all dismissed as impractical, imposing higher costs on energy generally, slowing economic growth in the process, and scaring people to adopt unwise public policies by exaggerating the certainty of predictions about man-made climate change. While dismissing the arguments advanced by 'old-school' environmentalists, the report does not question the validity of the overall theory or details of the core greenhouse effect, its main targets are the anthropogenic components of the observed temperature record, and the evidence of a clear cause-and-effect link between anthropogenic forcing and changes in the Earth's surface temperature. Overall, the report dismisses the 'conventional' view of the extent of climate change, the cause of that change and the risk it poses. It emphasizes the limitations on economic freedom that proposed policies would inflict, and argues in favour of more studies to provide the foundation for a societal response based on a solid understanding of the science behind climate change, and the impact of proposed policy options. 32 refs., 2 figs

  19. When does atopic dermatitis warrant systemic therapy?

    DEFF Research Database (Denmark)

    Simpson, Eric L; Bruin-Weller, Marjolein; Flohr, Carsten

    2017-01-01

    therapy in AD and provide a framework for evaluation before making this therapeutic decision with the patient. METHODS: A subgroup of the International Eczema Council determined aspects to consider before prescribing systemic therapy. Topics were assigned to expert reviewers who performed a topic...... systemic therapy include considering alternate or concomitant diagnoses, avoiding trigger factors, optimizing topical therapy, ensuring adequate patient/caregiver education, treating coexistent infection, assessing the impact on quality of life, and considering phototherapy. LIMITATIONS: Our work...

  20. When does atopic dermatitis warrant systemic therapy?

    DEFF Research Database (Denmark)

    Simpson, Eric L; Bruin-Weller, Marjolein; Flohr, Carsten

    2017-01-01

    -specific literature review, referred to guidelines when available, and provided interpretation and expert opinion. RESULTS: We recommend a systematic and holistic approach to assess patients with severe signs and symptoms of AD and impact on quality of life before systemic therapy. Steps taken before commencing......BACKGROUND: Although most patients with atopic dermatitis (AD) are effectively managed with topical medication, a significant minority require systemic therapy. Guidelines for decision making about advancement to systemic therapy are lacking. OBJECTIVE: To guide those considering use of systemic...... therapy in AD and provide a framework for evaluation before making this therapeutic decision with the patient. METHODS: A subgroup of the International Eczema Council determined aspects to consider before prescribing systemic therapy. Topics were assigned to expert reviewers who performed a topic...

  1. Enhanced sensitivity to the time variation of the fine-structure constant and mp/me in diatomic molecules: A closer examination of silicon monobromide

    International Nuclear Information System (INIS)

    Beloy, K.; Borschevsky, A.; Schwerdtfeger, P.; Flambaum, V. V.

    2010-01-01

    Recently it was pointed out that transition frequencies in certain diatomic molecules have an enhanced sensitivity to variations in the fine-structure constant α and the proton-to-electron mass ratio m p /m e due to a near cancellation between the fine structure and vibrational interval in a ground electronic multiplet [V. V. Flambaum and M. G. Kozlov, Phys. Rev. Lett. 99, 150801 (2007)]. One such molecule possessing this favorable quality is silicon monobromide. Here we take a closer examination of SiBr as a candidate for detecting variations in α and m p /m e . We analyze the rovibronic spectrum by employing the most accurate experimental data available in the literature and perform ab initio calculations to determine the precise dependence of the spectrum on variations in α. Furthermore, we calculate the natural linewidths of the rovibronic levels, which place a fundamental limit on the accuracy to which variations may be determined.

  2. At closer grips with ITP

    International Nuclear Information System (INIS)

    Heyns, A.du P.; Pieters, H.; Wessels, P.; Loetter, M.G.; Badenhorst, P.N.; Kotze, H.F.

    1986-01-01

    An excessive destruction of platelets characterises Immune Thrombocytopenic Purpura (ITP) - a relatively common blood disease, particularly in the young. With the use of In-111 as platelet label there was focused on the mean platelet life span, the efficacy of increased platelet production by the bone marrow in the face of increased platelet destruction, the role of the spleen in ITP, and the different patterns of platelet sequestration in this disease

  3. CERN/USSR: Closer collaboration

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    The decision of CERN Council to grant Observer status to the Soviet Union is a new milestone in a long history of collaboration between European and Soviet particle physicists which bodes well for the continued success of their research programmes

  4. Bringing fusion electric power closer

    International Nuclear Information System (INIS)

    Kintner, E.

    1977-01-01

    A review of the controlled fusion research program is given. The tokamak research program is described. Beam injection heating, control systems, and the safety of fusion reactors are topics that are also discussed

  5. Red - take a closer look.

    Directory of Open Access Journals (Sweden)

    Vanessa L Buechner

    Full Text Available Color research has shown that red is associated with avoidance of threat (e.g., failure or approach of reward (e.g., mating depending on the context in which it is perceived. In the present study we explored one central cognitive process that might be involved in the context dependency of red associations. According to our theory, red is supposed to highlight the relevance (importance of a goal-related stimulus and correspondingly intensifies the perceivers' attentional reaction to it. Angry and happy human compared to non-human facial expressions were used as goal-relevant stimuli. The data indicate that the color red leads to enhanced attentional engagement to angry and happy human facial expressions (compared to neutral ones - the use of non-human facial expressions does not bias attention. The results are discussed with regard to the idea that red induced attentional biases might explain the red-context effects on motivation.

  6. Looking closer at the Congo

    DEFF Research Database (Denmark)

    Jansson, Johanna; Jiang, Wenran

    2011-01-01

    An NGO report on Chinese investment in the Democratic Republic of Congo opens a vital debate, but its methodology leaves the reader wanting a fuller version of the facts, write Johanna Jansson and Jiang Wenran.......An NGO report on Chinese investment in the Democratic Republic of Congo opens a vital debate, but its methodology leaves the reader wanting a fuller version of the facts, write Johanna Jansson and Jiang Wenran....

  7. A TAD closer to ATM.

    Science.gov (United States)

    Aymard, Francois; Legube, Gaëlle

    2016-05-01

    Ataxia telangiectasia mutated (ATM) has been known for decades as the main kinase mediating the DNA double-strand break response. Our recent findings suggest that its major role at the sites of breaks likely resides in its ability to modify both the local chromatin landscape and the global chromosome organization in order to promote repair accuracy.

  8. Closer look at lunar volcanism

    International Nuclear Information System (INIS)

    Vaniman, D.T.; Heiken, G.; Taylor, G.J.

    1984-01-01

    Although the American Apollo and Soviet Luna missions concentrated on mare basalt samples, major questions remain about lunar volcanism. Lunar field work will be indispensable for resolving the scientific questions about ages, compositions, and eruption processes of lunar volcanism. From a utilitarian standpoint, a better knowledge of lunar volcanism will also yield profitable returns in lunar base construction (e.g., exploitation of rille or lava-tube structures) and in access to materials such as volatile elements, pure glass, or ilmenite for lunar industry

  9. Same-sex parenting and children's outcomes: A closer examination of the American psychological association's brief on lesbian and gay parenting.

    Science.gov (United States)

    Marks, Loren

    2012-07-01

    In 2005, the American Psychological Association (APA) issued an official brief on lesbian and gay parenting. This brief included the assertion: "Not a single study has found children of lesbian or gay parents to be disadvantaged in any significant respect relative to children of heterosexual parents" (p. 15). The present article closely examines this assertion and the 59 published studies cited by the APA to support it. Seven central questions address: (1) homogeneous sampling, (2) absence of comparison groups, (3) comparison group characteristics, (4) contradictory data, (5) the limited scope of children's outcomes studied, (6) paucity of long-term outcome data, and (7) lack of APA-urged statistical power. The conclusion is that strong assertions, including those made by the APA, were not empirically warranted. Recommendations for future research are offered. Copyright © 2012 Elsevier Inc. All rights reserved.

  10. Social scaling of extrapersonal space: target objects are judged as closer when the reference frame is a human agent with available movement potentialities.

    Science.gov (United States)

    Fini, C; Brass, M; Committeri, G

    2015-01-01

    Space perception depends on our motion potentialities and our intended actions are affected by space perception. Research on peripersonal space (the space in reaching distance) shows that we perceive an object as being closer when we (Witt, Proffitt, & Epstein, 2005; Witt & Proffitt, 2008) or another actor (Costantini, Ambrosini, Sinigaglia, & Gallese, 2011; Bloesch, Davoli, Roth, Brockmole, & Abrams, 2012) can interact with it. Similarly, an object only triggers specific movements when it is placed in our peripersonal space (Costantini, Ambrosini, Tieri, Sinigaglia, & Committeri, 2010) or in the other's peripersonal space (Costantini, Committeri, & Sinigaglia, 2011; Cardellicchio, Sinigaglia, & Costantini, 2013). Moreover, also the extrapersonal space (the space outside reaching distance) seems to be perceived in relation to our movement capabilities: the more effort it takes to cover a distance, the greater we perceive the distance to be (Proffitt, Stefanucci, Banton, & Epstein, 2003; Sugovic & Witt, 2013). However, not much is known about the influence of the other's movement potentialities on our extrapersonal space perception. Three experiments were carried out investigating the categorization of distance in extrapersonal space using human or non-human allocentric reference frames (RF). Subjects were asked to judge the distance ("Near" or "Far") of a target object (a beach umbrella) placed at progressively increasing or decreasing distances until a change from near to far or vice versa was reported. In the first experiment we found a significant "Near space extension" when the allocentric RF was a human virtual agent instead of a static, inanimate object. In the second experiment we tested whether the "Near space extension" depended on the anatomical structure of the RF or its movement potentialities by adding a wooden dummy. The "Near space extension" was only observed for the human agent but not for the dummy. Finally, to rule out the possibility that the

  11. Varant Yatırımcısının Volatilite Algısına Etki Eden Faktörler: BIST’de Ampirik Bir Uygulama(Factors Affecting the Volatility Perception of Warrant Investors: An Empirical Research on BIST

    Directory of Open Access Journals (Sweden)

    İsrafil ZOR

    2013-12-01

    Full Text Available The aim of the study is to determine the factors that affect the volatility perception of warrant investors. By using 3.187 daily data of 61 call warrants whose underlying asset is BIST-30 Index and traded on BIST in 2012, firstly efficient option pricing model for the related market is confirmed and then volatilities that equalizes the efficient model prices to market prices are calculated and regression analysis is applied to determine factors that affect the volatility. The results of the analysis are revealed that if the closing price of the underlying asset, the days to maturity of the warrant and Turkish Lira Interbank rate increase, the volatility perceived by investors will decrease. Also, there is positive relationship between the closing price of warrants and the perceived volatility. In addition perceived volatility is higher on Monday and first decrease in inflation after 4 months increase reduces the perceived volatility.

  12. Neural Progenitors in the Developing Neocortex of the Northern Tree Shrew (Tupaia belangeri Show a Closer Relationship to Gyrencephalic Primates Than to Lissencephalic Rodents

    Directory of Open Access Journals (Sweden)

    Sebastian Römer

    2018-04-01

    Full Text Available The neocortex is the most complex part of the mammalian brain and as such it has undergone tremendous expansion during evolution, especially in primates. The majority of neocortical neurons originate from distinct neural stem and progenitor cells (NPCs located in the ventricular and subventricular zone (SVZ. Previous studies revealed that the SVZ thickness as well as the abundance and distribution of NPCs, especially that of basal radial glia (bRG, differ markedly between the lissencephalic rodent and gyrencephalic primate neocortex. The northern tree shrew (Tupaia belangeri is a rat-sized mammal with a high brain to body mass ratio, which stands phylogenetically mid-way between rodents and primates. Our study provides – for the first time – detailed data on the presence, abundance and distribution of bRG and other distinct NPCs in the developing neocortex of the northern tree shrew (Tupaia belangeri. We show that the developing tree shrew neocortex is characterized by an expanded SVZ, a high abundance of Pax6+ NPCs in the SVZ, and a relatively high percentage of bRG at peak of upper-layer neurogenesis. We further demonstrate that key features of tree shrew neocortex development, e.g., the presence, abundance and distribution of distinct NPCs, are closer related to those of gyrencephalic primates than to those of ferret and lissencephalic rodents. Together, our study provides novel insight into the evolution of bRG and other distinct NPCs in the neocortex development of Euarchontoglires and introduces the tree shrew as a potential novel model organism in the area of human brain development and developmental disorders.

  13. Poly (glycerol sebacate) elastomer supports bone regeneration by its mechanical properties being closer to osteoid tissue rather than to mature bone.

    Science.gov (United States)

    Zaky, S H; Lee, K W; Gao, J; Jensen, A; Verdelis, K; Wang, Y; Almarza, A J; Sfeir, C

    2017-05-01

    Mechanical load influences bone structure and mass. Arguing the importance of load-transduction, we investigated the mechanisms inducing bone formation using an elastomeric substrate. We characterized Poly (glycerol sebacate) (PGS) in vitro for its mechanical properties, compatibility with osteoprogenitor cells regarding adhesion, proliferation, differentiation under compression versus static cultures and in vivo for the regeneration of a rabbit ulna critical size defect. The load-transducing properties of PGS were compared in vitro to a stiffer poly lactic-co-glycolic-acid (PLA/PGA) scaffold of similar porosity and interconnectivity. Under cyclic compression for 7days, we report focal adhesion kinase overexpression on the less stiff PGS and upregulation of the transcription factor Runx2 and late osteogenic markers osteocalcin and bone sialoprotein (1.7, 4.0 and 10.0 folds increase respectively). Upon implanting PGS in the rabbit ulna defect, histology and micro-computed tomography analysis showed complete gap bridging with new bone by the PGS elastomer by 8weeks while minimal bone formation was seen in empty controls. Immunohistochemical analysis demonstrated the new bone to be primarily regenerated by recruited osteoprogenitors cells expressing periostin protein during early phase of maturation similar to physiological endochondral bone development. This study confirms PGS to be osteoconductive contributing to bone regeneration by recruiting host progenitor/stem cell populations and as a load-transducing substrate, transmits mechanical signals to the populated cells promoting differentiation and matrix maturation toward proper bone remodeling. We hence conclude that the material properties of PGS being closer to osteoid tissue rather than to mineralized bone, allows bone maturation on a substrate mechanically closer to where osteoprogenitor/stem cells differentiate to develop mature load-bearing bone. The development of effective therapies for bone and

  14. A Thorough Scrutiny of ELT Textbook Evaluations: A Review Inquiry

    Directory of Open Access Journals (Sweden)

    Reza Gholami

    2017-07-01

    Full Text Available It is thoroughly agreed that English language textbooks stand amongst the foremost components in any language classrooms worldwide, being referred to as valid, beneficial and labor-saving tools to fulfill an extensive range of needs. An ELT textbook is not merely a set of sheets of paper fastened together to hinge at one side, but is the beating heart of any education system whereupon the whole learning revolves. Notwithstanding their interminable benefits, it is admitted that still the compiled textbooks, especially the ones prescribed in Educational systems have to be evaluated and assessed to confirm whether they fulfil the objectives they are meant for or not, as it is said no perfect textbook exists. Having dealt with evaluation in general, this research meticulously elaborates on textbook evaluation more specifically concluding that there is a dearth of inquiry on textbook selection and evaluation. Afterwards, this research introduces the most common approaches for evaluating ELT textbooks and materials. The paper culminates with concluding remarks and implications, hoping to shed light on how textbook evaluation is practiced worldwide.

  15. Controversial EU deportation programme subjected to academic scrutiny

    DEFF Research Database (Denmark)

    Lemberg-Pedersen, Martin; McClelland, Ian

    2013-01-01

    On 3 May 2013, the Refugee Studies Centre hosted a workshop in Oxford, co-convened by Martin Lemberg-Pedersen (University of Copenhagen) and Dawn Chatty (RSC), to shed light on the little-publicised European Return Platform for Unaccompanied Minors (ERPUM)...

  16. Permits for coal-fired power plants under scrutiny

    International Nuclear Information System (INIS)

    Hoekstra, B.

    2011-01-01

    The attorney-general of the European Court of Justice offered advice to the European Judge on the prejudicial questions of the Department of Administrative Law of the Council of State in the framework of appeal cases against environmental permits of three planned power plants in the Netherlands. The advice may have large consequences for these permits. [nl

  17. Transplant ethics under scrutiny - responsibilities of all medical professionals.

    Science.gov (United States)

    Trey, Torsten; Caplan, Arthur L; Lavee, Jacob

    2013-02-01

    In this text, we present and elaborate ethical challenges in transplant medicine related to organ procurement and organ distribution, together with measures to solve such challenges. Based on internationally acknowledged ethical standards, we looked at cases of organ procurement and distribution practices that deviated from such ethical standards. One form of organ procurement is known as commercial organ trafficking, while in China the organ procurement is mostly based on executing prisoners, including killing of detained Falun Gong practitioners for their organs. Efforts from within the medical community as well as from governments have contributed to provide solutions to uphold ethical standards in medicine. The medical profession has the responsibility to actively promote ethical guidelines in medicine to prevent a decay of ethical standards and to ensure best medical practices.

  18. Transplant ethics under scrutiny – responsibilities of all medical professionals

    Science.gov (United States)

    Trey, Torsten; Caplan, Arthur L.; Lavee, Jacob

    2013-01-01

    In this text, we present and elaborate ethical challenges in transplant medicine related to organ procurement and organ distribution, together with measures to solve such challenges. Based on internationally acknowledged ethical standards, we looked at cases of organ procurement and distribution practices that deviated from such ethical standards. One form of organ procurement is known as commercial organ trafficking, while in China the organ procurement is mostly based on executing prisoners, including killing of detained Falun Gong practitioners for their organs. Efforts from within the medical community as well as from governments have contributed to provide solutions to uphold ethical standards in medicine. The medical profession has the responsibility to actively promote ethical guidelines in medicine to prevent a decay of ethical standards and to ensure best medical practices. PMID:23444249

  19. Electricity under the critical scrutiny of parliament and the people

    International Nuclear Information System (INIS)

    1982-01-01

    The history of electricity power generation in Switzerland over the last hundred years is examined from the point of view of its social and political implications. Particular attention is paid to the forthcoming decision by parliament regarding the construction of a new atomic power station at Kaiseraugst in view of the increasing anti-nuclear energy lobby in Switzerland itself and in West Germany to whom considerable quantities of electricity are ''exported''. (R.S.)

  20. IMO and stakeholders looking for improvements: Pricing system under scrutiny

    International Nuclear Information System (INIS)

    Anon

    2002-01-01

    Changing the way of how Ontario's electric market clearing price is established has been announced by the Independent Market Operator, in response to excessive price fluctuations following deregulation, and in spite of the considerable concern about how any change to the pricing system might affect investor confidence. To tackle the issue, an internal team was formed, with input to this team through the IMO's Marker Operations Standing Committee. The following pricing issues are considered to be in need of attention: (1) the discrepancy between real-time prices and published pre-dispatch prices; (2) the difference between prices paid for imported power and domestic power during times of shortage; (3) the inclusion of various factors, such as the additional cost of imported power in non-competitive parts of energy bills known as 'uplift charges'; (4) the failure of the market clearing price to reflect the value of power; (5) the use of non-market procedures that have an effect on price; and (6) adjustments to the offer stack designed to reduce volatility during ramp-up periods. The IMO emphasized its keen awareness of how much investor confidence is predicated on the assumption that market conditions alone will determine prices. Accordingly, its actions are guided strictly by the desire to support reliability and are not intended to be seen as intervening in the competitive market

  1. Legal and scientific scrutiny of forensic 'sciences' and 'experts'

    International Nuclear Information System (INIS)

    Metz, H.O.E.

    2002-01-01

    Full text: Traditional areas of forensic science, such as, handwriting and fingerprint examinations and the newer sciences such as molecular biology are increasingly being scrutinized and challenged by the legal and scientific communities. These older forensic disciplines are targets for critics and skeptics as they are not founded on the traditional sciences but have rather an empirical basis and are supported by what may be considered quasi-validated data. This paper discusses in broad terms the basis of these legal and scientific attitudes and the various solutions to overcoming these negative perceptions. Werner Heisenberg (1901-1976; German physicist) 'An Expert is someone who knows some of the worst mistakes that can be made in his subject and who manages to avoid them'. (author)

  2. Flexitime under Scrutiny: Research on Work Adjustment and Organizational Performance.

    Science.gov (United States)

    Barad, Cary B.

    1980-01-01

    Reports on an in-house study of flexible working hours conducted by the Social Security Administration. On the basis of the study, management agreed that flextime could be implemented throughout the agency wherever feasible and where employee interest was sufficiently high. (Author/IRT)

  3. Obesity, metabolic profile, and inhibition failure: Young women under scrutiny.

    Science.gov (United States)

    Catoira, N P; Tapajóz, F; Allegri, R F; Lajfer, J; Rodríguez Cámara, M J; Iturry, M L; Castaño, G O

    2016-04-01

    The prevalence of obesity, as well as evidence about this pathology as a risk factor for cognitive decline and dementia in the elderly, is increasing worldwide. Executive functions have been found to be compromised in most studies, although the specific results are dissimilar. Obese young women constitute an interesting study and intervention group, having been found to be unaffected by age and hormonal negative effects on cognition and considering that their health problems affect not only themselves but their families and offspring. The objective of the present study was to compare the executive performance of obese young women with that of a healthy control group. A cross-sectional study was done among premenopausal women from a public hospital in Buenos Aires. The sample comprised 113 participants (32 healthy controls and 81 obese women), who were evaluated for depressive and anxiety symptoms (Beck Depression Inventory-II and State-Trait Anxiety Inventory) and executive functioning (Trail-Making Test B, Stroop Color and Word Test, Wisconsin Card Sorting Test, and verbal fluency test). Statistical analysis was done by using the SPSS version 20.0 software. Among executive functions, a significant difference was found between groups in inhibition (pcognitive test and 2h post-load glucose level. Inhibition was decreased in our obese young women group, and glucose/lipid metabolism may be involved in this association. The cognitive impairment is comparable with that described in addictive conditions. Our conclusions support the concept of multidisciplinary management of obese patients from the time of diagnosis. Detecting and understanding cognitive dysfunction in this population is essential to providing appropriate treatment. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. A Thorough Scrutiny of ELT Textbook Evaluations: A Review Inquiry

    Science.gov (United States)

    Gholami, Reza; Noordin, Nooreen; Rafik-Galea, Shameem

    2017-01-01

    It is thoroughly agreed that English language textbooks stand amongst the foremost components in any language classrooms worldwide, being referred to as valid, beneficial and labor-saving tools to fulfill an extensive range of needs. An ELT textbook is not merely a set of sheets of paper fastened together to hinge at one side, but is the beating…

  5. Falling Behind: International Scrutiny of the Peaceful Atom

    Science.gov (United States)

    2008-02-01

    confused with critical masses .5 Significant quantity values currently in use by the IAEA are given in Table 1. In a previous Natural Resources... actinides and fission products would not add significantly to the plutonium mass , the state could divert the spiked plutonium to a small clandestine...and manufacturing processes and should not be 152 confused with critical masses . Significant quantities are used in establishing the quantity

  6. Describing the trajectory of language development in the presence of severe-to-profound hearing loss: a closer look at children with cochlear implants versus hearing aids.

    Science.gov (United States)

    Yoshinaga-Itano, Christine; Baca, Rosalinda L; Sedey, Allison L

    2010-10-01

    The objective of this investigation was to describe the language growth of children with severe or profound hearing loss with cochlear implants versus those children with the same degree of hearing loss using hearing aids. A prospective longitudinal observation and analysis. University of Colorado Department of Speech Language and Hearing Sciences. There were 87 children with severe-to-profound hearing loss from 48 to 87 months of age. All children received early intervention services through the Colorado Home Intervention Program. Most children received intervention services from a certified auditory-verbal therapist or an auditory-oral therapist and weekly sign language instruction from an instructor who was deaf or hard of hearing and native or fluent in American Sign Language. The Test of Auditory Comprehension of Language, 3rd Edition, and the Expressive One Word Picture Vocabulary Test, 3rd Edition, were the assessment tools for children 4 to 7 years of age. The expressive language subscale of the Minnesota Child Development was used in the infant/toddler period (birth to 36 mo). Average language estimates at 84 months of age were nearly identical to the normative sample for receptive language and 7 months delayed for expressive vocabulary. Children demonstrated a mean rate of growth from 4 years through 7 years on these 2 assessments that was equivalent to their normal-hearing peers. As a group, children with hearing aids deviated more from the age equivalent trajectory on the Test of Auditory Comprehension of Language, 3rd Edition, and the Expressive One Word Picture Vocabulary Test, 3rd Edition, than children with cochlear implants. When a subset of children were divided into performance categories, we found that children with cochlear implants were more likely to be "gap closers" and less likely to be "gap openers," whereas the reverse was true for the children with hearing aids for both measures. Children who are educated through oral-aural combined with

  7. Issues with Access to Acquisition Data and Information in the Department of Defense: A Closer Look at the Origins and Implementation of Controlled Unclassified Information Labels and Security Policy

    Science.gov (United States)

    2016-12-01

    by law. This representation of RAND intellectual property is provided for noncommercial use only. Unauthorized posting of this publication online is...Office of the Secretary of Defense asked RAND to take a closer look at several key sources of inefficiency by evaluating how marking and labeling CUI...ability of data users to properly identify, label, and, if needed, challenge improperly marked data. Identifying which unclassified but potentially

  8. Issues with Access to Acquisition Data and Information in the Department of Defense: A Closer Look at the Origins and Implementation of Controlled Unclassified Information Labels and Security Policy

    Science.gov (United States)

    2016-12-19

    directly affect the access and utility of acquisition databases. The current information security environment does not establish a consistent... information ” without a nondisclosure agreement • proposing a legislative amendment to 10 U.S.C. 2320, which allows access to technical data for providing...ISSUES WITH Access to Acquisition Data and Information IN THE DEPARTMENT OF DEFENSE A Closer Look at the Origins and Implementation of

  9. Works scheduling. Warranting the availability of your facilities is one of our daily challenge. Scheduling our works with you favors this availability; Programmation des travaux. Garantir la disponibilite de vos installations constitue l'un de nos defis quotidiens. Programmer nos travaux avec vous favorise cette disponibilite

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-12-01

    One of the missions of the French manager of the power transportation grid (RTE) is to maintain and improve the performance of the network in order to warrant the security and quality of power supplies. Thus, any maintenance or development works leading to the unavailableness of the client's power connection requires a precise scheduling of these works. The aim of this brochure is to describe the procedure to follow in this case. (J.S.)

  10. Funding of drugs: do vaccines warrant a different approach?

    Science.gov (United States)

    Beutels, Philippe; Scuffham, Paul A; MacIntyre, C Raina

    2008-11-01

    Vaccines have features that require special consideration when assessing their cost-effectiveness. These features are related to herd immunity, quality-of-life losses in young children, parental care and work loss, time preference, uncertainty, eradication, macroeconomics, and tiered pricing. Advisory committees on public funding for vaccines, or for pharmaceuticals in general, should be knowledgable about these special features. We discuss key issues and difficulties in decision making for vaccines against rotavirus, human papillomavirus, varicella-zoster virus, influenza virus, and Streptococcus pneumoniae. We argue that guidelines for economic evaluation should be reconsidered generally to recommend (1) modelling options for the assessment of interventions against infectious diseases; (2) a wider perspective to account for impacts on third parties, if relevant; (3) a wider scope of costs than health-care system costs alone, if appropriate; and (4) alternative discounting techniques to explore social time preference over long periods.

  11. Is cardiac surgery warranted in children with Down syndrome? A ...

    African Journals Online (AJOL)

    Objectives. To compare children with Down syndrome and children without Down syndrome and investigate whether there is a significant difference in the burden that is placed on the health care system between these two groups only in respect of the repair of congenital heart disease at Red Cross War Memorial Children's ...

  12. Benefits of an Air Force Contracting Warrant Officer Program

    Science.gov (United States)

    2011-12-01

    M., & Berry, J. W. (2011). The necessity of others is the mother of invention: instrinsic and prosocial motivations , perspective taking, and...Capital, Organizational Behavioral Assessment, Implementation Plan, Air Force 16. PRICE CODE 17. SECURITY CLASSIFICATION OF REPORT Unclassified...10 3. Motivation

  13. A universal freeze all strategy: why it is not warranted.

    Science.gov (United States)

    Ata, Baris; Seli, Emre

    2017-06-01

    There's some preclinical evidence of an adverse effect of multifollicular growth on endometrial function in assisted reproductive technology cycles. Universal elective frozen embryo transfer (eFET) in an unstimulated cycle is being promoted as a panacea, regardless of patient, and cycle characteristics. We review the clinical evidence on the effectiveness and safety of eFETs. Randomized controlled trials (RCTs) comparing fresh and eFET yield contradictory results in terms of live birth rates. RCTs mainly involve women with an excessive response to ovarian stimulation. Studies including women with a normal or low ovarian response are either patient/physician preference or retrospective studies, prone to bias. Yet, they yield contradictory results as well. Overall, eFET seems to have limited potential to improve effectiveness of assisted reproductive technology, which could be limited to hyper-responders. Other suggested advantages of eFET include better obstetric and perinatal outcome. However, recent studies show that frozen embryo transfers can be associated with serious complications including hypertensive disorders during pregnancy, placenta accreta, or increased perinatal mortality. The evidence behind advantages of eFET is of low quality. As such, switching to a universal eFET strategy does not seem justified. New RCTs including women from different strata of ovarian response are needed.

  14. Becoming a Graduate: The Warranting of an Emergent Identity

    Science.gov (United States)

    Holmes, Leonard M.

    2015-01-01

    Purpose: With expansion of higher education in most developed and developing economies, graduates constitute a large section of the workforce. However, even prior to the economic problems of the past few years, the transition from higher education into graduate employment has not been and is not straightforward. The purpose of this paper is to…

  15. Fumigant emission reductions with TIF warrant regulatory changes

    Directory of Open Access Journals (Sweden)

    Husein Ajwa

    2013-07-01

    Full Text Available With methyl bromide's phase-out, most growers have turned to alternative fumigants, particularly 1,3-dichloropropene (1,3-D and chloropicrin. These alternatives are tightly regulated because they are classified as toxic air contaminants and volatile organic compounds; the latter combine with other substances to produce ground-level ozone (smog. Two ambient air monitoring studies were conducted to evaluate the potential of totally impermeable film (TIF to reduce emissions from shank applications of chloropicrin and 1,3-D. In 2009, a study demonstrated that TIF reduced chloropicrin and 1,3-D peak emissions by 45% and 38%, respectively, but TIF did not reduce total emissions when it was cut after 6 days. In 2011, increasing the tarp period from 5 to 10 days decreased chloropicrin and 1,3-D peak emissions by 88% and 78%, and their total emissions by 64% and 43%, respectively. Concurrent dynamic flux chamber results corroborated the ambient air monitoring data. These studies provide regulatory agencies with mitigation measures that should allow continued fumigant use at efficacious application rates.

  16. Symbols and warrants for major traffic generator guide signing.

    Science.gov (United States)

    2009-09-01

    The Texas Manual on Uniform Traffic Control Devices (TMUTCD) provides the definition of regular traffic generators based on four population types but not for major traffic generators (MTGs). MTG signs have been considered to supplement the overall si...

  17. Temperature impacts on economic growth warrant stringent mitigation policy

    Science.gov (United States)

    Moore, Frances C.; Diaz, Delavane B.

    2015-02-01

    Integrated assessment models compare the costs of greenhouse gas mitigation with damages from climate change to evaluate the social welfare implications of climate policy proposals and inform optimal emissions reduction trajectories. However, these models have been criticized for lacking a strong empirical basis for their damage functions, which do little to alter assumptions of sustained gross domestic product (GDP) growth, even under extreme temperature scenarios. We implement empirical estimates of temperature effects on GDP growth rates in the DICE model through two pathways, total factor productivity growth and capital depreciation. This damage specification, even under optimistic adaptation assumptions, substantially slows GDP growth in poor regions but has more modest effects in rich countries. Optimal climate policy in this model stabilizes global temperature change below 2 °C by eliminating emissions in the near future and implies a social cost of carbon several times larger than previous estimates. A sensitivity analysis shows that the magnitude of climate change impacts on economic growth, the rate of adaptation, and the dynamic interaction between damages and GDP are three critical uncertainties requiring further research. In particular, optimal mitigation rates are much lower if countries become less sensitive to climate change impacts as they develop, making this a major source of uncertainty and an important subject for future research.

  18. The Warrant for Constructivist Practice within Educational Technology.

    Science.gov (United States)

    Bopry, Jeanette

    1999-01-01

    Discusses educational technology as a form of technical rationality and considers the conflict between practitioners' epistemological position as constructivists and technical rationality. Topics include cybernetics; autonomous systems theory; enactive constructivism; representation versus effective action; mind and memory; enaction in artificial…

  19. Do perfume additives termed human pheromones warrant being termed pheromones?

    Science.gov (United States)

    Winman, Anders

    2004-09-30

    Two studies of the effects of perfume additives, termed human pheromones by the authors, have conveyed the message that these substances can promote an increase in human sociosexual behaviour [Physiol. Behav. 75 (2003) R1; Arch. Sex. Behav. 27 (1998) R2]. The present paper presents an extended analysis of this data. It is shown that in neither study is there a statistically significant increase in any of the sociosexual behaviours for the experimental groups. In the control groups of both studies, there are, however, moderate but statistically significant decreases in the corresponding behaviour. Most notably, there is no support in data for the claim that the substances increase the attractiveness of the wearers of the substances to the other sex. It is concluded that more research using matched homogenous groups of participants is needed. Copyright 2004 Elsevier Inc.

  20. Funding of drugs : do vaccines warrant a different approach?

    NARCIS (Netherlands)

    Beutels, Philippe; Scuffham, Paul A.; MacIntyre, C. Raina

    2008-01-01

    Vaccines have features that require special consideration when assessing their cost-effectiveness. These features are related to herd immunity, quality-of-life losses in young children, parental care and work loss, time preference, uncertainty, eradication, macroeconomics, and tiered pricing.

  1. Students Build Mathematical Theory: Semantic Warrants in Argumentation

    Science.gov (United States)

    Walter, Janet G.; Barros, Tara

    2011-01-01

    In this paper, we explore the development of two grounded theories. One theory is mathematical and grounded in the work of university calculus students' collaborative development of mathematical methods for finding the volume of a solid of revolution, in response to mathematical necessity in problem solving, without prior instruction on solution…

  2. Adult-onset offenders: Is a tailored theory warranted?

    Science.gov (United States)

    Beckley, Amber L.; Caspi, Avshalom; Harrington, Honalee; Houts, Renate M.; Mcgee, Tara Renae; Morgan, Nick; Schroeder, Felix; Ramrakha, Sandhya; Poulton, Richie; Moffitt, Terrie E.

    2016-01-01

    Purpose To describe official adult-onset offenders, investigate their antisocial histories and test hypotheses about their origins. Methods We defined adult-onset offenders among 931 Dunedin Study members followed to age 38, using criminal-court conviction records. Results Official adult-onset offenders were 14% of men, and 32% of convicted men, but accounted for only 15% of convictions. As anticipated by developmental theories emphasizing early-life influences on crime, adult-onset offenders’ histories of antisocial behavior spanned back to childhood. Relative to juvenile-offenders, during adolescence they had fewer delinquent peers and were more socially inhibited, which may have protected them from conviction. As anticipated by theories emphasizing the importance of situational influences on offending, adult-onset offenders, relative to non-offenders, during adulthood more often had schizophrenia, bipolar disorder, and alcohol-dependence, had weaker social bonds, anticipated fewer informal sanctions, and self-reported more offenses. Contrary to some expectations, adult-onset offenders did not have high IQ or high socioeconomic-status families protecting them from juvenile conviction. Conclusions A tailored theory for adult-onset offenders is unwarranted because few people begin crime de novo as adults. Official adult-onset offenders fall on a continuum of crime and its correlates, between official non-offenders and official juvenile-onset offenders. Existing theories can accommodate adult-onset offenders. PMID:27134318

  3. Heely injuries: a new epidemic warranting a government health warning!

    Science.gov (United States)

    Lenehan, B; Callender, O; McIntyre, A; Boran, S; Moore, D; Fogarty, E; Dowling, F

    2007-08-01

    Heelys, the new craze gripping the nation, were first introduced to Ireland in 2005 having been available in the United States since 2000. Designed as "the only shoe with a removable wheel in the sole" and initially marketed among rollerbladers and skateboarders they have been adopted by children as contemporary footwear. From April to June 2006, all patients presenting to trauma orthopaedic services at our institutions with injuries sustained while wearing Heelys were included in this study. Thirty-nine patients are included in this study. The mean age was 9.1 years (range 7-13, median 9 years). Of the 39 patients referred to the orthopaedic service, 8 required admissions to hospital. One patient admitted following a head injury, required craniotomy and evacuation of an extradural haematoma. The significance of the injuries encountered demonstrates the potentially devastating results from the use of Heelys. The public perception of safety is incorrect and manufacturers rightly recommend strongly the use of safety gear.

  4. Instability in Thoracolumbar Trauma: Is a New Definition Warranted?

    Science.gov (United States)

    Abbasi Fard, Salman; Skoch, Jesse; Avila, Mauricio J; Patel, Apar S; Sattarov, Kamran V; Walter, Christina M; Baaj, Ali A

    2017-10-01

    Review of the articles. The objective of this study was to review all articles related to spinal instability to determine a consensus statement for a contemporary, practical definition applicable to thoracolumbar injuries. Traumatic fractures of the thoracolumbar spine are common. These injuries can result in neurological deficits, disability, deformity, pain, and represent a great economic burden to society. The determination of spinal instability is an important task for spine surgeons, as treatment strategies rely heavily on this assessment. However, a clinically applicable definition of spinal stability remains elusive. A review of the Medline database between 1930 and 2014 was performed limited to papers in English. Spinal instability, thoracolumbar, and spinal stability were used as search terms. Case reports were excluded. We reviewed listed references from pertinent search results and located relevant manuscripts from these lists as well. The search produced a total of 694 published articles. Twenty-five articles were eligible after abstract screening and underwent full review. A definition for spinal instability was described in only 4 of them. Definitions were primarily based on biomechanical and classification studies. No definitive parameters were outlined to define stability. Thirty-six years after White and Panjabi's original definition of instability, and many classification schemes later, there remains no practical and meaningful definition for spinal instability in thoracolumbar trauma. Surgeon expertise and experience remains an important factor in stability determination. We propose that, at an initial assessment, a distinction should be made between immediate and delayed instability. This designation should better guide surgeons in decision making and patient counseling.

  5. Closer look at white-coat hypertension.

    Science.gov (United States)

    Sipahioglu, Nurver Turfaner; Sipahioglu, Fikret

    2014-09-26

    This review aims to clarify novel concepts regarding the clinical and laboratory aspects of white-coat hypertension (WCHT). Recent studies on the clinical and biological implications of WCHT were compared with existing knowledge. Studies were included if the WCHT patients were defined according to the 2013 European Society of Hypertension guidelines, i.e., an office blood pressure (BP) of ≥ 140/90 mmHg, a home BP of ≤ 135/85 mmHg, and a mean 24-h ambulatory BP of ≤ 130/80 mmHg. WCHT studies published since 2000 were selected, although a few studies performed before 2000 were used for comparative purposes. True WCHT was defined as normal ABPM and home BP readings, and partial WCHT was defined as an abnormality in one of these two readings. The reported prevalence of WCHT was 15%-45%. The incidence of WCHT tended to be higher in females and in non-smokers. Compared with normotensive (NT) patients, WCHT was associated with a higher left ventricular mass index, higher lipid levels, impaired fasting glucose, and decreased arterial compliance. The circadian rhythm in WCHT patients was more variable than in NT patient's, with a higher pulse pressure and non-dipping characteristics. Compared with sustained hypertension patients, WCHT patients have a better 10-year prognosis; compared with NT patients, WCHT patients have a similar stroke risk, but receive more frequent drug treatment. There are conflicting results regarding WCHT and markers of endothelial damage, oxidative stress and inflammation, and the data imply that WCHT patients may have a worse prognosis. Nitric oxide levels are lower, and oxidative stress parameters are higher in WCHT patients than in NT patients, whereas the antioxidant capacity is lower in WCHT patients than in NT patients. Clinicians should be aware of the risk factors associated with WCHT and patients should be closely monitored especially to identify target organ damage and metabolic syndrome.

  6. A Closer Look at Jamnitzer's Polyhedra

    OpenAIRE

    van den Broeke, A.; Ruttkay, Z.M.; Sarhangi, R.; Sequin, C.

    2008-01-01

    The Renaissance artist Wentzel Jamnitzer designed series of intriguing polyhedra in perspective in his book “Perspectiva Corporum Regularium��?. In this paper we investigate the possible principles of the construction of the polyhedra and create 3D computer models of them. Comparing those to the originals, we get an idea of how successful he was in drawing the complex structures by imagination. Furthermore, we analyse Jamnitzer's use of linear perspective, an important key in creating such dr...

  7. Taking a Closer Look at Writing Conferences.

    Science.gov (United States)

    Florio-Ruane, Susan

    Current literature on writing instruction focuses on the writing conference, which accompanies a shift in emphasis from product to process and potentially transforms the teacher's role from task master and evaluator to respondent, opening the door to greater peer interaction in literacy learning. However desirable this ideal may be, extant…

  8. A closer look at prion strains

    Science.gov (United States)

    Solforosi, Laura; Milani, Michela; Mancini, Nicasio; Clementi, Massimo; Burioni, Roberto

    2013-01-01

    Prions are infectious proteins that are responsible for transmissible spongiform encephalopathies (TSEs) and consist primarily of scrapie prion protein (PrPSc), a pathogenic isoform of the host-encoded cellular prion protein (PrPC). The absence of nucleic acids as essential components of the infectious prions is the most striking feature associated to these diseases. Additionally, different prion strains have been isolated from animal diseases despite the lack of DNA or RNA molecules. Mounting evidence suggests that prion-strain-specific features segregate with different PrPSc conformational and aggregation states. Strains are of practical relevance in prion diseases as they can drastically differ in many aspects, such as incubation period, PrPSc biochemical profile (e.g., electrophoretic mobility and glycoform ratio) and distribution of brain lesions. Importantly, such different features are maintained after inoculation of a prion strain into genetically identical hosts and are relatively stable across serial passages. This review focuses on the characterization of prion strains and on the wide range of important implications that the study of prion strains involves. PMID:23357828

  9. KT gets even closer to CERN people

    CERN Multimedia

    2015-01-01

    For several years, the Knowledge Transfer (KT) group has been helping CERN people to disseminate their results, know-how and technologies to new fields of application. This may be anything from working with a school, hospital or a company through a licence or collaboration agreement, to securing CERN’s intellectual property rights or even starting a company. In order to maximise the impact of CERN’s work and to provide a service adapted to its users’ needs, the KT group has launched a survey.   Assessing the needs and wishes of the CERN personnel with regard to knowledge transfer activities: this is the goal of the survey that the KT group has launched this week. “Science and engineering are key disciplines in tackling the fundamental challenges facing the planet, such as energy, security, climate change, the sustainability of natural resources and economic resilience,” says Thierry Lagrange, head of the Finance, Procurement and Knowledge Transfer...

  10. Asia is Closer than You Think.

    Science.gov (United States)

    Conner, Mary E.

    1998-01-01

    Contends that regional studies, such as Asian studies, can engage students more actively than a traditional global approach to world history. Delineates the author's objectives in teaching a course in Asian studies. Outlines the subjects covered in the course's units on China, Japan, and Korea. (DSK)

  11. Prospects for Closer Israeli-NATO Cooperation

    Science.gov (United States)

    2015-09-01

    Actions and Arab Perceptions.” In The Middle East and the United States, 5th ed., edited by David W. Lesch and Mark L. Haas, 177–96. Boulder, CO...Ibid. 110 David W. Lesch, Mark L. Haas, eds., The Middle East and the United States, 5th ed. (Boulder, CO, Westview Press, 2014), 2 21 beginning...to Israel in 2005, NATO Secretary General Jaap de Hoop Scheffer stated, “the interplay of Middle Eastern and transatlantic security is becoming

  12. European Science Research Organisations forge closer ties

    CERN Multimedia

    2001-01-01

    Effective collaboration has always been one of the foundations of CERN's success. An essential ingredient for collaboration is communication and a new body EIROFORUM has just held its first meeting in Brussels with the aim of developing greater cross fertilization of ideas and projects. Seven organisations, CERN, EMBL (molecular biology), ESA (space activities), ESO (astronomy and astrophysics), ESRF (synchrotron radiation), ILL (neutron source) and EFDA (fusion) are currently members of EIROFORUM. Common interest between the organisations in computational grid development, materials science, instrumentation, public outreach and technology transfer has made EIROFRUM an essential group for maximising these European research organisations' resources. Increasing involvement in the Sixth Framework Programme, Europe's research guidelines for the next four years, is also one of the goals of the group. CERN takes over the chair of EIROFORUM in July 2001 and the next meeting will be held on site on 24 October .

  13. Nuclear Genome Size: Are We Getting Closer?

    Czech Academy of Sciences Publication Activity Database

    Doležel, Jaroslav; Greilhuber, J.

    77A, č. 7 (2010), s. 635-642 ISSN 1552-4922 R&D Projects : GA MŠk(CZ) LC06004 Institutional research plan: CEZ:AV0Z50380511 Keywords : cytometric techniques * reference standards * genome sequencing Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.749, year: 2010

  14. A closer look at adaptive regret

    NARCIS (Netherlands)

    D. Adamskyi (Dmitri); W.M. Koolen-Wijkstra (Wouter); A. Chernov (Alexey); V. Vovk

    2016-01-01

    textabstractFor the prediction with expert advice setting, we consider methods to construct algorithms that have low adaptive regret. The adaptive regret of an algorithm on a time interval [t1,t2] is the loss of the algorithm minus the loss of the best expert over that interval. Adaptive regret

  15. Opting out of an ever closer union

    DEFF Research Database (Denmark)

    Adler-Nissen, Rebecca

    2011-01-01

    How is sovereignty managed in the EU? This paper investigates the relationship between sovereignty and European integration through the prism of national opt-outs from EU treaties, addressing an apparent contradiction in contemporary European governance: the contrasting processes of integration...... and differentiation. On the one hand, European integration is increasing as states transfer sovereign competencies to the EU. On the other hand, we see a multitude of differentiation processes through which member states choose to disengage from the EU polity by negotiating exemptions or derogations. Drawing...... on Pierre Bourdieu’s political sociology, the paper argues that to understand how sovereignty is exercised and interpreted in the EU, it is necessary to focus not only on the constitutive and regulative dimensions of sovereignty, but equally on the practice dimension. This entails an exploration of how...

  16. Global aesthetic surgery statistics: a closer look.

    Science.gov (United States)

    Heidekrueger, Paul I; Juran, S; Ehrl, D; Aung, T; Tanna, N; Broer, P Niclas

    2017-08-01

    Obtaining quality global statistics about surgical procedures remains an important yet challenging task. The International Society of Aesthetic Plastic Surgery (ISAPS) reports the total number of surgical and non-surgical procedures performed worldwide on a yearly basis. While providing valuable insight, ISAPS' statistics leave two important factors unaccounted for: (1) the underlying base population, and (2) the number of surgeons performing the procedures. Statistics of the published ISAPS' 'International Survey on Aesthetic/Cosmetic Surgery' were analysed by country, taking into account the underlying national base population according to the official United Nations population estimates. Further, the number of surgeons per country was used to calculate the number of surgeries performed per surgeon. In 2014, based on ISAPS statistics, national surgical procedures ranked in the following order: 1st USA, 2nd Brazil, 3rd South Korea, 4th Mexico, 5th Japan, 6th Germany, 7th Colombia, and 8th France. When considering the size of the underlying national populations, the demand for surgical procedures per 100,000 people changes the overall ranking substantially. It was also found that the rate of surgical procedures per surgeon shows great variation between the responding countries. While the US and Brazil are often quoted as the countries with the highest demand for plastic surgery, according to the presented analysis, other countries surpass these countries in surgical procedures per capita. While data acquisition and quality should be improved in the future, valuable insight regarding the demand for surgical procedures can be gained by taking specific demographic and geographic factors into consideration.

  17. A TAD Closer to Understanding Dosage Compensation.

    Science.gov (United States)

    Wood, Andrew J; Bickmore, Wendy A

    2015-06-08

    Eukaryotic chromosomes are organized into topological domains, but how these are established and maintained is poorly understood. Writing in Nature, Crane et al. (2015) show that a specialized condensin complex enforces the domain boundaries along the C. elegans X chromosome to equalize transcription from the X between males and hermaphrodites. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. Getting logistics closer to end users

    NARCIS (Netherlands)

    Luis, J.G.; Hernández, J.G.; Rodriguez, G.P.; Carcel, G.H.; Hofman, W.

    2014-01-01

    Nowadays, logistics could make you purchase a book in Amazon and delivering it in 24-hours using a service from a logistics operator or a transport company. In a more complex scenario, an order could be traveling around the globe, passing from hand to hand between unknown actors for months. In most

  19. A closer look at web questionnaire design

    NARCIS (Netherlands)

    Toepoel, V.

    2008-01-01

    This dissertation deals with the design of online questionnaires and its consequences for data quality: what is the effect of the number of items placed on a screen, the response categories, layout choices et cetera. It also focuses on attrition and panel conditioning: what do people learn from

  20. A Closer Look at the Law.

    Science.gov (United States)

    McNamee, Mike

    1990-01-01

    Charities have an obligation to give donors "accurate and sufficient information concerning the deductibility of contributions." Donors must subtract any benefit of "substantial value" from their gifts. The value of a benefit is based on its fair market value, not on its cost to the charity. (MLW)

  1. Medical humanities: a closer look at learning.

    Science.gov (United States)

    Patterson, A; Sharek, D; Hennessy, M; Phillips, M; Schofield, S

    2016-06-01

    The inclusion of medical humanities with medical curricula is a question that has been the focus of attention for many within the evolving field. This study addressed the question from a medical education perspective and aimed to investigate what students at Trinity College Dublin learned from participating in a short medical humanities student-selected module in their first year of an undergraduate medical programme. A total of 156 students provided a written reflection on a memorable event that occurred during their student-selected module. The reflections were analysed using the Reflection Evaluation for Learners' Enhanced Competencies Tool (REFLECT) and through qualitative thematic analysis of the written reflections. Evidence of learning from the REFLECT quantitative analysis showed that 50% of students displayed higher levels of reflection when describing their experience. The reflection content analysis supported the heterogeneous nature of learning outcome for students, with evidence to support the idea that the module provided opportunities for students to explore their beliefs, ideas and feelings regarding a range of areas outside their current experience or world view, to consider the views of others that they may have not previously been aware of, to reflect on their current views, and to consider their future professional practice. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  2. A Closer Look at Jamnitzer's Polyhedra

    NARCIS (Netherlands)

    van den Broeke, A.; Ruttkay, Z.M.; Sarhangi, R.; Sequin, C.

    The Renaissance artist Wentzel Jamnitzer designed series of intriguing polyhedra in perspective in his book “Perspectiva Corporum Regularium��?. In this paper we investigate the possible principles of the construction of the polyhedra and create 3D computer models of them. Comparing those to the

  3. Analytical investigations closer to the patient.

    OpenAIRE

    Watson, D

    1980-01-01

    Do-it-yourself bioanalytical equipment that requires no analytical skill to operate is currently available for use in intensive care units, operating suites, side wards, health centres, clinics, general practitioners' surgeries, etc. Agreement is needed between the laboratory consultant and doctors and others using laboratory-type equipment and reagents in near-bedside analyses for diagnosis, clinical management, or health screening of their patients. Choice and safety of method procedure, op...

  4. Closer integration called for in Vihula

    Index Scriptorium Estoniae

    2011-01-01

    11. veebruaril Vihulas toimunud Balti ministrite nõukogu peaministrite mitteametlikul kohtumisel räägiti majanduspoliitika, energeetika ja digitaalse siseturu loomise teemadel. Läti peaministri Valdis Dombrovskise arvamused. Kohtumisest võttis osa ka Euroopa Komisjoni rahandus- ja majandusvolinik Olli Rehn

  5. News Conference: Physics brings the community together Training: CERN trains physics teachers Education: World conference fosters physics collaborations Lecture: Physics education live at ASE Prize: Physics teacher wins first Moore medal Festival: European presidents patronize Science on Stage festival Videoconference: Videoconference brings Durban closer to the classroom

    Science.gov (United States)

    2012-03-01

    Conference: Physics brings the community together Training: CERN trains physics teachers Education: World conference fosters physics collaborations Lecture: Physics education live at ASE Prize: Physics teacher wins first Moore medal Festival: European presidents patronize Science on Stage festival Videoconference: Videoconference brings Durban closer to the classroom

  6. Buffalo embryos produced by handmade cloning from oocytes selected using brilliant cresyl blue staining have better developmental competence and quality and are closer to embryos produced by in vitro fertilization in terms of their epigenetic status and gene expression pattern.

    Science.gov (United States)

    Mohapatra, Sushil K; Sandhu, Anjit; Neerukattu, Venkata S; Singh, Karn P; Selokar, Naresh L; Singla, Suresh K; Chauhan, Manmohan S; Manik, Radhey S; Palta, Prabhat

    2015-04-01

    We compared handmade cloned (HMC) buffalo blastocysts produced from oocytes stained with Brilliant Cresyl Blue (BCB) and classified into those with blue (BCB+) or colorless cytoplasm (BCB-). The blastocyst rate was higher (p<0.001) for BCB+ than for BCB- oocytes (43.41 ± 2.54 vs. 22.74 ± 1.76%). BCB+ blastocysts had inner cell mass (ICM) cell number, ICM-to-trophectoderm ratio, global level of H3K18ac, apoptotic index, and expression level of BCL-XL, but not that of CASPASE-3, similar to that of blastocysts produced through in vitro fertilization (IVF), which was higher (p<0.05) than that of BCB- blastocysts. The global level of H3K9me2, which was similar in BCB+ and BCB- blastocysts, was higher (p<0.01) than that in IVF blastocysts. The expression level of OCT4 and SOX2 was higher (p<0.05) and that of GATA2 was lower (p<0.05) in BCB+ than that in BCB- blastocysts, whereas that of DNMT1, DNMT3a, NANOG, and CDX2 was not significantly different between the two groups. The expression level of DNMT1, OCT4, NANOG, and SOX2 was lower (p<0.05) and that of CDX2 was higher (p<0.05) in BCB+ than in IVF blastocysts. In conclusion, because BCB+ blastocysts have better developmental competence and are closer to IVF blastocysts in terms of quality, epigenetic status, and gene expression than BCB- blastocysts, BCB staining can be used effectively for selection of developmentally competent oocytes for HMC.

  7. It's a sentence, not a word: insights from a keyword analysis in cancer communication.

    Science.gov (United States)

    Taylor, Kimberly; Thorne, Sally; Oliffe, John L

    2015-01-01

    Keyword analysis has been championed as a methodological option for expanding the insights that can be extracted from qualitative datasets using various properties available in qualitative software. Intrigued by the pioneering applications of Clive Seale and his colleagues in this regard, we conducted keyword analyses for word frequency and "keyness" on a qualitative database of interview transcripts from a study on cancer communication. We then subjected the results from these operations to an in-depth contextual inquiry by resituating word instances within their original speech contexts, finding that most of what had initially appeared as group variations broke down under close analysis. In this article, we illustrate the various threads of analysis, and explain how they unraveled under closer scrutiny. On the basis of this tentative exercise, we conclude that a healthy skepticism for the benefits of keyword analysis within a qualitative investigative process seems warranted. © The Author(s) 2014.

  8. Controversies on the beginning of human life - science and religions closer and closer.

    Science.gov (United States)

    Kurjak, Asim

    2017-04-01

    One of the most controversial topics in modern bioethics, science, and philosophy is the beginning of individual human life. In the seemingly endless debate, strongly stimulated by recent technologic advances in human reproduction, a synthesis between scientific data and hypothesis, philosophical thought, and issues of humanities has become a necessity to deal with ethical, juridical, and social problems. Furthermore, in this field there is a temptation to ask science to choose between opinions and beliefs, which neutralize one another. The question of when human life begins requires the essential aid of different forms of knowledge. Here we become involved in the juncture between science and religion, which needs to be carefully explored.

  9. Central pressures and central hemodynamic values in white coat hypertensives are closer to those of normotensives than to those of controlled hypertensives for similar age, gender, and 24-h and nocturnal blood pressures.

    Science.gov (United States)

    Almeida, Joana; Monteiro, José; Silva, José A; Bertoquini, Susana; Polónia, Jorge

    2016-11-01

    There is disagreement whether white coat hypertensives (WCH) have different hemodynamic and structural characteristics compared to normotensives (NT) and hypertensives (HT). We compared cardiovascular prognostic markers (pulse wave velocity [PWV] and aortic stiffness index [ASI]) and data on central hemodynamics and central pressures (augmentation index [AIx], augmentation pressure [AugP] and pulse pressure amplification [PPA]) from aortic pulse wave analysis between NT (n=175), WCH (n=315) and treated HT (n=691), all with 24-h blood pressure (BP) <130/80 and nocturnal BP <120/70 mmHg after matching for age, gender, body mass index (BMI) and and nocturnal BP. The groups were also compared separately in terms of 24-h systolic BP <120 mmHg and 120-129 mmHg. The percentage of non-dippers was 40.1% in NT, 34.5% in WCH and 38.3 in HT. For similar 24-h and nocturnal systolic BP (NT 109/64±7/5, WCH 110/66±7/6, HT 109/64±7/5 mmHg), aortic stiffness was greater in HT (n=691, PWV 10.8±2.6 m/s and ASI 0.33±0.16, p<0.01) than in WCH (n=316, PWV 9.7±2.4 m/s and ASI 0.28±0.17) and NT (n=175, PWV 9.5±2.0 m/s and ASI 0.29±0.15); AugP and AIx were higher (p<0.01) in HT (13.9±8.2 and 29.6±12.6 mmHg) than in WCH (11.5±8.5 mmHg and 24.9±15.2) and NT (11.0±6.4 mmHg and 26.6±11.5). PPA was lower (p<0.01) in HT (11.3±5.5 mmHg) than in WCH (13.2±7.1 mmHg) and in NT (12.4±4.9 mmHg). The findings were similar when the 24-h systolic BP <120 mmHg and 120-129 mmHg subgroups were analyzed separately. Our data suggest that for similar age, gender distribution, BMI, and 24-h and nocturnal BP, aortic stiffness, central aortic pressures and wave reflection in WCH are closer to those of NT than to those with treated HT. This supports the idea that white coat hypertension may be a more benign condition than treated hypertension for similar 24-h and particularly nocturnal BP levels. Copyright © 2016 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All

  10. The passage of Australia’s data retention regime: national security, human rights, and media scrutiny

    Directory of Open Access Journals (Sweden)

    Nicolas Suzor

    2017-03-01

    Full Text Available In 2015, the Australian government passed the Telecommunications (Interception and Access Amendment (Data Retention Act, which requires ISPs to collect metadata about their users and store this metadata for two years. From its conception, Australia’s data retention scheme has been controversial. In this article we examine how public interest concerns were addressed in Australian news media during the Act’s passage. The Act was ultimately passed with bipartisan support, despite serious deficiencies. We show how the Act’s complexity seemed to limit engaged critique in the mainstream media and how fears over terrorist attacks were exploited to secure the Act’s passage through parliament.

  11. Name-letter branding under scrutiny: real products, new algorithms, and the probability of buying.

    Science.gov (United States)

    Stieger, Stefan

    2010-06-01

    People like letters matching their own first and last name initials more than nonname letters. This name-letter effect has also been found for brands, i.e., people like brands resembling their own name letters (initial or first three). This has been termed name-letter branding effect. In the present study of 199 participants, ages 12 to 79 years, this name-letter branding effect was found for a modified design (1) using real products, (2) concentrating on product names rather than brand names, (3) using five different products for each letter of the Roman alphabet, (4) asking for the buying probability, and (5) using recently introduced algorithms, controlling for individual response tendencies (i.e., liking all letters more or less) and general normative popularity of particular letters (i.e., some letters are generally preferred more than other letters).

  12. From federated federalism to converging federalism? The case of EU subsidiarity scrutiny in Spain and Belgium

    NARCIS (Netherlands)

    Vandamme, T.

    2012-01-01

    In political science literature, federal systems may be classified as ‘dual’ or ‘co-operative’ polities. This contribution further explores this dichotomy between dual and co-operative systems from the perspective of Spain and Belgium, two EU member states that may be qualified as ‘dual’ systems.

  13. From federated federalism to harmonized federalism: the case of EU subsidiarity scrutiny in Spain and Belgium

    NARCIS (Netherlands)

    Vandamme, T.

    2011-01-01

    In political science literature, federal systems can be classified as ‘dual’ or ‘cooperative’ polities. Also for legal research, this classification has proven to be a good tool for analysis as evidenced by the recent work of Robert Schütze when he described the evolution of the EU from a dual to a

  14. A scrutiny of the educational value of EFL mobile learning applications

    Directory of Open Access Journals (Sweden)

    Cristina Calle Martínez

    2014-08-01

    Full Text Available Mobile learning is without any doubt the next step in the evolution of educational technology as it offers modern methods of support to the process of learning through the use of mobile instruments. However, although there are a huge number of educational applications in the market at the moment, the educational value of many of them is rather questionable. The final aim of the SO-CALL-ME ((Social Ontology-based Cognitively Augmented Language Learning Mobile Environment (FFI 2011-29829 research project is to design and create EFL mobile applications that successfully combine technical skills and a solid pedagogy. In this light, the present study is the third phase of a line of research which started in 2012. In the first phase 67 MALL applications in the context of EFL were assessed by means of a rubric not on their technical features but on their pedagogic goals. The results gave us an idea of the qualities and limitations of the apps examined. In the second phase, a quality guide was created as the basis for a more elaborate evaluation rubric. Out of the EFL apps previously analyzed with the first rubric, we chose four that fulfilled the features considered most important for the apps to be developed in a final stage of the research project. In the third phase, a rubric was used to evaluate the linguistic adequacy of EFL apps for listening. The present study offers the evaluation of a higher number of apps using the rubrics created in phases 2 and 3 in order to corroborate the first impressions as a final step before using the quality guide for the creation of EFL applications.

  15. Dematerialization—A Disputable Strategy for Resource Conservation Put under Scrutiny

    Directory of Open Access Journals (Sweden)

    Felix Müller

    2017-12-01

    Full Text Available Dematerialization is a paradigm in resource conservation strategies. Material use should be reduced so that resource consumption as a whole can be lowered. The benefit for humankind should be completely decoupled from the natural expenditure by a definite factor X. Instinctively, this approach is convincing, because our entire value-added chain is based on material transformation. Targets for mass-based indicators are found within the context of justification for ecological carrying capacity and intergenerational fairness, taking into account the economic and socio-political expectation of raw material scarcity. However, in light of further development of material flow indicators and the related dematerialization targets, the question arises as to what they actually stand for and what significance they have for resource conservation. Can it be assumed that pressure on the environment will decline steadily if the use of materials is reduced, whether for an economy or at the level of individual products or processes? The present narrative review paper has discussed this issue and takes into account the authors’ experience of the extended political and scientific discourse on dematerialization in Germany and Europe. As a result, a high “resource relevance” cannot be inferred from high physical material inputs at any of the levels considered. It has been shown that establishing mass-based indicators as control and target variables is questionable and that dematerialization exclusively based on such indicators without mapping other resources should be critically examined.

  16. Japan seeks targeted science funding and to use external scrutiny to increase competitiveness at universities

    CERN Multimedia

    Saegusa, A

    1999-01-01

    Japan's science policy committee is planning to prioritise research fields in an attempt to better support high-priority research areas such as information sciences and genome research. The Science and Technology Council has also asked for the formation of an independent body to externally evaluate the quality of university research (1 page).

  17. New arrangements, new scrutiny. The IRS reconsiders hospital-physician relationships at tax-exempt facilities.

    Science.gov (United States)

    Sullivan, T J

    1992-01-01

    The pressure to maintain adequate operating margins has forced many not-for-profit hospitals to adopt more overtly competitive behavior than they have in the past. However, in struggling to remain economically viable, these facilities should carefully avoid actions that would threaten their tax-exempt status. Not-for-profit facilities should be particularly careful that their arrangements with physicians, which often appear designed to increase referrals, do not violate the criteria according to which the Internal Revenue Code extends tax exemption to charitable organizations. Section 501(c)(3) of the code exempts organizations "no part of the net earnings of which inures to the benefit of any private shareholder or individual." According to this provision, "insiders" (i.e., those with a personal interest in or opportunity to influence organization activities from the inside) are entitled to no more than reasonable payment for their goods or services. The Internal Revenue Service (IRS) takes the position that, as employees or individuals having a close professional working relationship with a hospital, physicians are insiders. Thus a hospital that pays physicians what the IRS judges to be more than fair market value for services (or charges physicians less than fair market value for office rental) may find its exemption in jeopardy. If not-for-profit hospitals want to maintain their tax-exempt status, they must be certain the arrangements they enter into with physicians truly further their exempt purpose: to promote the health of the community.

  18. Permits for coal-fired power plants under scrutiny; Vergunningen kolencentrales onder vuur

    Energy Technology Data Exchange (ETDEWEB)

    Hoekstra, B. [Tauw, Deventer (Netherlands)

    2011-02-15

    The attorney-general of the European Court of Justice offered advice to the European Judge on the prejudicial questions of the Department of Administrative Law of the Council of State in the framework of appeal cases against environmental permits of three planned power plants in the Netherlands. The advice may have large consequences for these permits. [Dutch] De advocaat-generaal (A-G) van het Europese Hof van Justitie heeft haar advies uitgebracht aan de Europese rechter over de prejudiciele vragen van de Afdeling bestuursrechtspraak van de Raad van State in het kader van beroepszaken tegen de milieuvergunningen van een drietal geplande elektriciteitscentrales in Nederland. Het advies kan grote consequenties hebben voor deze vergunningen.

  19. The burden of poofs: criminal pathology, clinical scrutiny, and homosexual etiology in queer cinema.

    Science.gov (United States)

    Wahlert, Lance

    2013-06-01

    Given the resurgence of scientific studies on the etiology of homosexuality in the wake of the AIDS epidemic, this article considers the effects these studies had on contemporaneous queer filmmakers. By using the subject of criminality as a way to talk about homosexual causality, queer films of the 1990s illustrate that contemporary scientific studies on homosexuality were historically and politically situated in relation to cultural anxieties about other forms of deviance. This article focuses on films that dissect the hetero-normative tendency to amalgamate forms of deviance in order to distinguish between the diseased and the healthy. Such products of New Queer Cinema highlight this amalgamation of criminality and homosexuality in order to challenge demands by the LGBT community of the 1980s and 1990s for "more positive images" in film. This article argues that queer filmmakers have manipulated the image of the queer criminal to usurp the medical tendency to biologize and pathologize the notion of queer transgression. In such a way, queer films that enthusiastically dramatize the queer outlaw perpetuate myths about homosexuality in order to dissect and discredit them.

  20. Scrutiny of underdeveloped nanofluid MHD flow and heat conduction in a channel with porous walls

    Directory of Open Access Journals (Sweden)

    M. Fakour

    2014-11-01

    Full Text Available In this paper, laminar fluid flow and heat transfer in channel with permeable walls in the presence of a transverse magnetic field is investigated. Least square method (LSM for computing approximate solutions of nonlinear differential equations governing the problem. We have tried to show reliability and performance of the present method compared with the numerical method (Runge–Kutta fourth-rate to solve this problem. The influence of the four dimensionless numbers: the Hartmann number, Reynolds number, Prandtl number and Eckert number on non-dimensional velocity and temperature profiles are considered. The results show analytical present method is very close to numerically method. In general, increasing the Reynolds and Hartman number is reduces the nanofluid flow velocity in the channel and the maximum amount of temperature increase and increasing the Prandtl and Eckert number will increase the maximum amount of theta.

  1. A Scrutiny of the Equivalent Static Lateral Load Method of Design for Multistory Masonry Structures

    International Nuclear Information System (INIS)

    Touqan, A. R.; Helou, S. H.

    2008-01-01

    Building structures with a soft storey are gaining widespread popularity in urban areas due to the scarcity of land and due to the pressing need for wide open spaces at the entrance level. In earthquake prone zones dynamic analysis based on the Equivalent Static Lateral Load method is attractive to the novice and the design codes leave the choice of the analysis procedure up to the discretion of the designer. The following is a comparison of the said method with the more elaborate Response Spectrum Method of analysis as they apply to a repertoire of different structural models. The results clearly show that the former provides similar results of response in structures with gradual change in storey stiffness; while it is over conservative for a bare frame structure. It is however less conservative for structures with a soft storey

  2. Domestic scrutiny of European Union politics: Between whistle blowing and opposition control / Daniel Finke, Tanja Dannwolf

    Index Scriptorium Estoniae

    Finke, Daniel

    2013-01-01

    Artikkel käsitleb liikmesriikide järelevalvet Euroopa Liidu poliitika üle, küsides, miks ühed seadusandlikud ettepanekud kutsuvad esile parlamendikomisjonide põhjaliku kontrolli, teised läbivad komisjoni lihtsalt. Peale koalitsiooni järelevalve ELi asjade üle pööratakse tähelepanu opositsiooni kontrollivale tegevusele

  3. Interactions 1 as an ELT coursebook: a curricular and theory-based scrutiny

    Directory of Open Access Journals (Sweden)

    Sevilla Morales, Henry

    2015-09-01

    Full Text Available El presente artículo analiza la pertinencia del libro Interactions 1 como texto utilizado en el curso IO-5400 Comunicación Oral I, perteneciente al primer año de la carrera de Bachillerato en la Enseñanza del inglés en una universidad pública en Costa Rica. En este sentido, se estudia la metodología propuesta en el texto, su diseño (imágenes, estrategias didácticas para el desarrollo de habilidades orales y auditivas, recursos que acompañan el texto, entre otros y su enfoque curricular, a fin de determinar la congruencia entre los principios teóricos que establecen los autores acerca de la evaluación y el diseño de los recursos didácticos y el texto supra citado. Asimismo, se analizó la pertinencia de dicho texto con diferentes aspectos que contiene el currículo de la carrera como: el perfil de salida del estudiante, los objetivos y la metodología, entre otros. El estudio se basó en una metodología de investigación descriptiva donde se combinan estrategias para la recolección de la información, tales como listas de cotejo y escalas Likert. El análisis e interpretación de los datos se realizó mediante la triangulación de fuentes. El estudio devela, por una parte, que el nivel de coherencia del texto Interactions 1 con los principios teóricos para el diseño y la evaluación de recursos didácticos, es insuficiente con respecto a los criterios especializados para esta área. Por otra parte, en relación con los aspectos del currículo de la carrera, resulta aceptable en tanto el docente debe contextualizarlo y complementarlo con sus propios recursos y estrategias didácticas para que resulte totalmente satisfactorio al proceso de aprendizaje del idioma Inglés. El aporte fundamental del estudio comprueba la necesidad de utilizar criterios técnicos para el diseño de recursos didácticos afines al enfoque curricular de los planes de estudios de Enseñanza del Inglés.

  4. Axial buckling scrutiny of doubly orthogonal slender nanotubes via nonlocal continuum theory

    Energy Technology Data Exchange (ETDEWEB)

    Kiani, Keivan [K.N. Toosi University of Technolog, Tehran (Iran, Islamic Republic of)

    2015-10-15

    Using nonlocal Euler-Bernoulli beam theory, buckling behavior of elastically embedded Doubly orthogonal single-walled carbon nanotubes (DOSWCNTs) is studied. The nonlocal governing equations are obtained. In fact, these are coupled fourth-order integroordinary differential equations which are very difficult to be solved explicitly. As an alternative solution, Galerkin approach in conjunction with assumed mode method is employed, and the axial compressive buckling load of the nanosystem is evaluated. For DOSWCNTs with simply supported tubes, the influences of the slenderness ratio, aspect ratio, intertube free space, small-scale parameter, and properties of the surrounding elastic matrix on the axial buckling load of the nanosystem are addressed. The proposed model could be considered as a pivotal step towards better understanding the buckling behavior of more complex nanosystems such as doubly orthogonal membranes or even jungles of carbon nanotubes.

  5. Quality of environmental impact statements and variability of scrutiny by reviewers

    International Nuclear Information System (INIS)

    Peterson, Kaja

    2010-01-01

    Adequate provision of information is essential for decision making. This paper provides the results of the quality assessment of Environmental Impact Statements (EIS), documents prescribed by EIA Directive (337/85/EEC). The assessment was completed by several categories of reviewers in Estonia, which has been an EU member state since 2004. The quality assessment of EIS was based on the EC Guidance on EIS Review (2001). Firstly, the quality assessment of 50 randomly selected EIS was carried out by a single reviewer. Secondly, the individual grading among 24 independent reviewers of a single EIS was tested. Thirdly, a comparison of the results of 15 individual and 5 group assessments of the same EIS was conducted. The results from the quality assessment of the selected EIS demonstrate a satisfactory level of information provided for decision making; 68% of the sample EIS were positively graded. However, more than half of the 50 EIS were graded as 'just satisfactory'. Comparison between the individual and group assessment of the same EIS demonstrates that the group assessment is more critical than the individual assessment. This possibly results from a wider technical expertise and balancing of subjective values and perspectives among group members. Arguably, the current practice of EIA competent authorities assessing the quality of EIS with individuals could be revised. We discuss the effect of the group assessment on expanding the narrow technical expertise and the subjectivity of a single expert.

  6. Does Tacit Knowledge Predict Organizational Performance? A Scrutiny of Firms in the Upstream Sector in Nigeria

    Directory of Open Access Journals (Sweden)

    Vincent I.O Odiri

    2016-02-01

    Full Text Available This paper examined tacit knowledge so as to see whether tacit knowledge when properly put to use can lead to improved performance by upstream sector firms in Nigeria. Knowledge as we believe, is very vital to both corporate entities and individuals. Knowledge encompasses both explicit and tacit. This paper focused on one aspect of knowledge – ‘tacit’ which is in the psyche or brain of the individual possessing it. Inspite of the central role it plays, tacit knowledge has been downplayed by most firms. However, we adopted a survey research design via questionnaires administered to 504 employees randomly selected from 3 different oil firms. The data obtained were analyzed using inferential statistics. Also, multi-collinearity diagnoses of tacit knowledge and organizational performance was performed. The result suggests that tacit knowledge is linearly correlated with organizational performance. This implies that tacit knowledge predicts organizational performance. This study is significant in that the findings would be useful to management of firms, as it divulge how tacit knowledge when properly harnessed can lead to increased performance. Most prior studies in this area were conducted in other countries, hence our study is one of the first in Nigeria that examined tacit knowledge and organizational performance.

  7. College Affirmative Action Faces Much Tougher Scrutiny in New Supreme Court Review

    Science.gov (United States)

    Schmidt, Peter

    2012-01-01

    The Supreme Court's members generally are too decorous to exclaim "I told you so." But U.S. Supreme Court Justice Anthony M. Kennedy stands perched on the edge of an I-told-you-so moment, thanks to the court's decision to take up a challenge to a race-conscious college-admission policy that poses some of the same questions he had accused…

  8. INTERACTIONS 1 AS AN ELT COURSEBOOK: A CURRICULAR AND THEORY-BASED SCRUTINY

    Directory of Open Access Journals (Sweden)

    Henry Sevilla Morales

    2015-01-01

    Full Text Available El presente artículo analiza la pertinencia del libro Interactions 1 como texto utilizado en el curso IO-5400 Comunicación Oral I, perteneciente al primer año de la carrera de Bachillerato en la Enseñanza del inglés en una universidad pública en Costa Rica. En este sentido, se estudia la metodología propuesta en el texto, su diseño (imágenes, estrategias didácticas para el desarrollo de habilidades orales y auditivas, recursos que acompañan el texto, entre otros y su enfoque curricular, a fin de determinar la congruencia entre los principios teóricos que establecen los autores acerca de la evaluación y el diseño de los recursos didácticos y el texto supra citado. Asimismo, se analizó la pertinencia de dicho texto con diferentes aspectos que contiene el currículo de la carrera como: el perfil de salida del estudiante, los objetivos y la metodología, entre otros. El estudio se basó en una metodología de investigación descriptiva donde se combinan estrategias para la recolección de la información, tales como listas de cotejo y escalas Likert. El análisis e interpretación de los datos se realizó mediante la triangulación de fuentes. El estudio devela, por una parte, que el nivel de coherencia del texto Interactions 1 con los principios teóricos para el diseño y la evaluación de recursos didácticos, es insuficiente con respecto a los criterios especializados para esta área. Por otra parte, en relación con los aspectos del currículo de la carrera, resulta aceptable en tanto el docente debe contextualizarlo y complementarlo con sus propios recursos y estrategias didácticas para que resulte totalmente satisfactorio al proceso de aprendizaje del idioma Inglés. El aporte fundamental del estudio comprueba la necesidad de utilizar criterios técnicos para el diseño de recursos didácticos afines al enfoque curricular de los planes de estudios de Enseñanza del Inglés.

  9. Lessons for Tuberculosis from scrutiny of HIV/AIDS and Malaria UK Parliamentary Questions

    Directory of Open Access Journals (Sweden)

    Matt Oliver

    2015-03-01

    Conclusion: High volumes of WPQs targeting specific policy areas or geographical locations can play a role in increasing political commitment within government towards a certain disease or condition, however other factors, including high-level MP champions and party policy, can play an equally significant role. Nonetheless, evidence suggests that a broad base of political support (as manifested through WPQs is important to motivating a government response to a health issue and that the TB community should devote more effort to mobilising this wide political support.

  10. A scrutiny of tools used for assessment of hospital disaster preparedness in Iran.

    Science.gov (United States)

    Heidaranlu, Esmail; Ebadi, Abbas; Ardalan, Ali; Khankeh, Hamidreza

    2015-01-01

    In emergencies and disasters, hospitals are among the first and most vital organizations involved. To determine preparedness of a hospital to deal with crisis, health system requires tools compatible with the type of crisis. The present study aimed to evaluate the accuracy of tools used for assessment of hospitals preparedness for major emergencies and disasters in Iran. In this review study, all studies conducted on hospital preparedness to deal with disasters in Iran in the interim 2000-2015 were examined. The World Health Organization (WHO) criteria were used to assess focus of studies for entry in this study. Of the 36 articles obtained, 28 articles that met inclusion criteria were analyzed. In accordance with the WHO standards, focus of tools used was examined in three areas (structural, nonstructural, and functional). In nonstructural area, the most focus of preparation tools was on medical gases, and the least focus on office and storeroom furnishings and equipment. In the functional area, the most focus was on operational plan, and the least on business continuity. Half of the tools in domestic studies considered structural safety as indicator of hospital preparedness. The present study showed that tools used contain a few indicators approved by the WHO, especially in the functional area. Moreover, a lack of a standard indigenous tool was evident, especially in the functional area. Thus, to assess hospital disaster preparedness, the national health system requires new tools compatible with scientific tool design principles, to enable a more accurate prediction of hospital preparedness in disasters before they occur.

  11. Tin- and Lead-Based Perovskite Solar Cells under Scrutiny: An Environmental Perspective

    DEFF Research Database (Denmark)

    Serrano-Luján, Lucía; Espinosa Martinez, Nieves; Larsen-Olsen, Thue Trofod

    2015-01-01

    The effect of substituting lead with tin in perovskite-based solar cells (PSCs) has shows that lead is preferred over tin by a lower cumulative energy demand. The results, which also include end-of-life management, show that a recycling scenario that carefully handles emission of lead enables use...

  12. Who Becomes a Limited Duty Officer and Chief Warrant Officer? An Examination of Differences of Limited Duty Officers and Chief Warrant Officers

    National Research Council Canada - National Science Library

    Manuel, Walter F

    2006-01-01

    .... Descriptive statistics, correlation analysis was developed for year groups 1990 through 2005 to analyze the differences in background characteristics and military characteristics of both programs...

  13. Agreement Moves Nevada Solar Plant Step Closer to Reality

    Science.gov (United States)

    Secretary Christine Ervin, CSTRR President Rose McKinney-James and NREL Director Dr. Charles Gay today new partnership, NREL will make available its facilities to test renewable energy technologies, help other renewable technologies. NREL will support the efforts of DOE's Federal Energy Management Program

  14. Primary prevention of colorectal cancer: are we closer to reality?

    LENUS (Irish Health Repository)

    Qasim, Asghar

    2012-02-01

    Colorectal cancer is one of the leading causes of morbidity and mortality worldwide. An early detection of colorectal cancer determines therapeutic outcomes, while primary prevention remains a challenge. Our aim was to review the dietary, geographical and genetic factors in the causation and their possible role in the primary prevention of colorectal cancer. Data from experimental and clinical studies and population screening programmes were analysed to determine the factors responsible for causation of colorectal cancer. The role of dietary constituents, including the consumption of fat, red meat, fibre content, alcohol consumption, and other lifestyle issues, including obesity, lack of exercise and geographical variations in cancer prevalence were reviewed. The role of genetic and lifestyle factors in causation of colorectal cancer is evident from the experimental, clinical and population-based studies. Dietary factors, including the consumption of fat, fibre, red meat and alcohol, seem to have a significant influence in this regard. The role of micronutrients, vitamins, calcium may be relevant but remain largely unclear. In conclusion, there is ample evidence favouring the role of various dietary and lifestyle factors in the aetiology of colorectal cancer. Modification of these factors is an attractive option, which is likely to help in the primary prevention and reduced disease burden.

  15. Into the mire: A closer look at fossil fuel subsidies

    Directory of Open Access Journals (Sweden)

    Radoslaw (Radek Stefanski

    2016-03-01

    Full Text Available Threatened by climate change, governments the world over are attempting to nudge markets in the direction of less carbon-intensive energy. Perversely, many of these governments continue to subsidize fossil fuels, distorting markets and raising emissions. Determining how much money is involved is difficult, as neither the providers nor the recipients of those subsidies want to own up to them. This paper builds on a unique method to extract fossil fuel subsidies from patterns in countries’ carbon emission-to-GDP ratios. This approach is useful since it: 1 overcomes the problem of scarce data; 2 derives a wider and more comparable measure of subsidies than existing measures and 3 allows for the performance of counterfactuals which help measure the impact of subsidies on emissions and growth. The resultant 170-country, 30-year database finds that the financial and the environmental costs of such subsidies are enormous, especially in China and the U.S. The overwhelming majority of the world’s fossil fuel subsidies stem from China, the U.S. and the ex-USSR; as of 2010, this figure was $712 billion or nearly 80 per cent of the total world value of subsidies. For its part, Canada has been subsidizing rather than taxing fossil fuels since 1998. By 2010, Canadian subsidies sat at $13 billion, or 1.4 per cent of GDP. In that same year, the total global direct and indirect financial costs of all such subsidies amounted to $1.82 trillion, or 3.8 per cent of global GDP. Aside from the money saved, in 2010 a world without subsidies would have had carbon emissions 36 per cent lower than they actually were. Any government looking to ease strained budgets and make a significant (and cheap contribution to the fight against climate change must consider slashing fossil fuel subsidies. As the data show, this is a sound decision – fiscally and environmentally.

  16. Living closer to the environment: Housing design concept

    Directory of Open Access Journals (Sweden)

    Kosorić Vesna

    2011-01-01

    Full Text Available The main idea of this design concept is to strengthen the relationship and understanding between a man - resident and his environment. Residents are separated from the outdoor environment by glazing, which enables constant observation of environment from nearly all points of indoor space, encouraging positive feelings towards external world and understanding of the fragility of biosphere. Care for the environment should become a part of a man's nature and way of living, and it is the people who are expected to become the driving force of positive global changes towards sustainable development. The semisphere-like single family house of 14m in diameter has a multifunctional, multi-layer 'active' facade envelope. The envelope ensures constant visual contact of residents with the whole surroundings, while still providing comfort. The living space of the house reflects natural shapes which are organic rather than rectangular. Such indoor space becomes a part of the environment, rather than being protected, distanced and isolated from it. The house is designed to use solar energy 'passively' by absorption through insulated glazed envelope and 'actively' by outer skin layer on the first floor, made of stripes of flat semi-transparent polycrystalline photovoltaic (PV panels. In addition to its constructive role, the concrete core of the house acts as thermal mass and enables absorption and accumulation of thermal energy. The developed housing concept is applicable in different urban-design units and sets.

  17. Estonia in closer ties with Canada / Ella Karapetyan

    Index Scriptorium Estoniae

    Karapetyan, Ella

    2010-01-01

    Välisminister Urmas Paet kohtus Kanada välisministri Lawrence Cannoni ja kaitseminister Peter MacKay'ga. Kohtumisel räägiti Eesti panusest Afganistani ja Arktika arengusse. Välisminister kohtus ka eesti kogukonnaga

  18. Diseases and Molecular Diagnostics: A Step Closer to Precision Medicine.

    Science.gov (United States)

    Dwivedi, Shailendra; Purohit, Purvi; Misra, Radhieka; Pareek, Puneet; Goel, Apul; Khattri, Sanjay; Pant, Kamlesh Kumar; Misra, Sanjeev; Sharma, Praveen

    2017-10-01

    The current advent of molecular technologies together with a multidisciplinary interplay of several fields led to the development of genomics, which concentrates on the detection of pathogenic events at the genome level. The structural and functional genomics approaches have now pinpointed the technical challenge in the exploration of disease-related genes and the recognition of their structural alterations or elucidation of gene function. Various promising technologies and diagnostic applications of structural genomics are currently preparing a large database of disease-genes, genetic alterations etc., by mutation scanning and DNA chip technology. Further the functional genomics also exploring the expression genetics (hybridization-, PCR- and sequence-based technologies), two-hybrid technology, next generation sequencing with Bioinformatics and computational biology. Advances in microarray "chip" technology as microarrays have allowed the parallel analysis of gene expression patterns of thousands of genes simultaneously. Sequence information collected from the genomes of many individuals is leading to the rapid discovery of single nucleotide polymorphisms or SNPs. Further advances of genetic engineering have also revolutionized immunoassay biotechnology via engineering of antibody-encoding genes and the phage display technology. The Biotechnology plays an important role in the development of diagnostic assays in response to an outbreak or critical disease response need. However, there is also need to pinpoint various obstacles and issues related to the commercialization and widespread dispersal of genetic knowledge derived from the exploitation of the biotechnology industry and the development and marketing of diagnostic services. Implementation of genetic criteria for patient selection and individual assessment of the risks and benefits of treatment emerges as a major challenge to the pharmaceutical industry. Thus this field is revolutionizing current era and further it may open new vistas in the field of disease management.

  19. Minnesota Kids: A Closer Look. 2000 Data Book.

    Science.gov (United States)

    Coffin, Linda

    This Kids Count data book examines trends in the well-being of Minnesota's children. The statistical portrait is based on 11 indicators of child well-being: (1) child poverty rate; (2) children receiving free or reduced-price school lunch; (3) children in families receiving food stamps; (4) births to teenage mothers; (5) low birth weight rates;…

  20. Warning: Projects May Be Closer than They Appear

    Science.gov (United States)

    Africa, Colby

    2004-01-01

    I had been working for two years as the technical product manager for a large software company, when their partner company gave me a call. They needed good software engineers to customize a new version of software, and they thought I was their guy. They told me what they wanted to do to the software, and they even showed me some prototypes. Their idea was to take the basic software tool that the large company was producing and make it more accessible to the customer. They would do this by building in flexibility based on user skill level and organizational maturity. I thought that was a fascinating approach, and I bought into it in a big way. I decided to leave my job and join up with the smaller company as their director of software engineering.

  1. The tramway worksite edges ever closer to CERN

    CERN Multimedia

    DG Unit

    2009-01-01

    You will have probably noticed that worksite machinery has been installed opposite CERN’s Gate A. They are carrying out work in preparation for the major tramway worksite that is due to reach CERN in a few weeks’ time. This preliminary work should cause no disruption to traffic. Full information on the tramway worksite adjacent to CERN’s Meyrin site will be published in forthcoming issues of the Bulletin. The traffic arrangements on the outskirts of Meyrin village will be modified with effect from 2 February. The section of the Route de Meyrin between the Avenue de Vaudagne and the roundabout at the intersection with Avenue J.-D.-Maillard/Chemin de la Planche will be closed off to traffic. Access to the Hôpital de la Tour will remain unchanged. Diversion signs to the centre of the village will be in operation. More information at http://www.way-tram.ch

  2. QUANTUM COMPUTING: Quantum Entangled Bits Step Closer to IT.

    Science.gov (United States)

    Zeilinger, A

    2000-07-21

    In contrast to today's computers, quantum computers and information technologies may in future be able to store and transmit information not only in the state "0" or "1," but also in superpositions of the two; information will then be stored and transmitted in entangled quantum states. Zeilinger discusses recent advances toward using this principle for quantum cryptography and highlights studies into the entanglement (or controlled superposition) of several photons, atoms, or ions.

  3. SLAM POETRY: A SIMPLE WAY TO GET CLOSER WITH LITERATURE

    Directory of Open Access Journals (Sweden)

    Murti Ayu Wijayanti

    2017-04-01

    Full Text Available Teaching literature in teacher training faculty in which the students are prepared for being English teachers is always challenging as the students think that they have nothing to do with any kinds of literary work. It takes times to prepare them learn literature. Most students think that they have no talent in literature. Thus, it will certainly affect the teaching and learning process. While the lecturer is teaching, the students tend to listen and think of another else but literature. It therefore needs the lecturer‘s effort to deal with this challenge. One part of literary works taught which creates problem for most of students is poetry. One way to encourage students in learning poetry is slam poetry. Slam poetry is a kind of poetry competition which was firstly popularized in America in 1990s. A rumor that only beautiful and rhythmic poetry which is highly appreciated vanishes since the poet will only write what he or she understands. In slam poetry, the students themselves create their own poetry and present it in front of their classmates whereas other students will be the judges and decide who the winner of this slam poetry is. This method will encourage the students to learn poetry as well as appreciate it.

  4. Seaside recreation in Oslo : bringing Bispevika closer to the city

    OpenAIRE

    Kloster-Jensen, Erlend Andre Borka

    2017-01-01

    Oslo is a growing city. Instead of letting the city expand beyond its borders, the municipality wants to use sites by the Oslo fjord for urban growth. The planning agency of Oslo is currently working on redefining the seaside, with the intent of making it more accessible to the public. One of the agency’s efforts in providing seaside recreation for Oslo’s citizens is called Havnepromenaden, which is to become a 9-kilometer long promenade along the Oslo fjord. This thesis treats the topi...

  5. Closer to zero: Reflections on ten years of ART rollout

    African Journals Online (AJOL)

    Mostly I think that they felt helpless and were not aware of what was happening ... filled with passion to learn more about HIV and treatment options. But they were ... prevented access to treatment, but also resulted in many of those accessing ...

  6. Nuclear plant owners move closer to life extension

    International Nuclear Information System (INIS)

    Smith, D.J.

    1991-01-01

    A major debate is now underway about the safety of 40-year-old nuclear power plants. Under the Atomic Energy Act of 1954 a nuclear power plant's license is limited to a maximum of 40 years. Although the act permits the renewal of an operating license, it does not outline any standards or procedures for determining when or under what conditions a plant's operating license should be renewed. This paper reports that the Electric Power Research Institute (EPRI) and the U.S. Department of Energy (DOE) are co-sponsors of a program to demonstrate the license renewal process for two nuclear power plants - Yankee Atomic Electric's 175-MW Yankee PWR plant and Northern States Power's 536-MW Monticello BWR plant. The demonstration is known as the lead plant project. Yankee Atomic has already analyzed the plant's condition and evaluated aging using computer-based expert systems and the plant's operating experience. During these tests Yankee Atomic found embrittlement of the reactor vessel

  7. A closer look at prion strains: characterization and important implications.

    Science.gov (United States)

    Solforosi, Laura; Milani, Michela; Mancini, Nicasio; Clementi, Massimo; Burioni, Roberto

    2013-01-01

    Prions are infectious proteins that are responsible for transmissible spongiform encephalopathies (TSEs) and consist primarily of scrapie prion protein (PrP (Sc) ), a pathogenic isoform of the host-encoded cellular prion protein (PrP (C) ). The absence of nucleic acids as essential components of the infectious prions is the most striking feature associated to these diseases. Additionally, different prion strains have been isolated from animal diseases despite the lack of DNA or RNA molecules. Mounting evidence suggests that prion-strain-specific features segregate with different PrP (Sc) conformational and aggregation states. Strains are of practical relevance in prion diseases as they can drastically differ in many aspects, such as incubation period, PrP (Sc) biochemical profile (e.g., electrophoretic mobility and glycoform ratio) and distribution of brain lesions. Importantly, such different features are maintained after inoculation of a prion strain into genetically identical hosts and are relatively stable across serial passages. This review focuses on the characterization of prion strains and on the wide range of important implications that the study of prion strains involves.

  8. Cognitive-Behavioral Therapy and Neuroscience: Towards Closer Integration

    Directory of Open Access Journals (Sweden)

    Nataša Jokić-Begić

    2010-12-01

    Full Text Available The aim of this review article is to provide an integrative perspective by combining basic assumptions of cognitive behavioral therapy (CBT with neuroscience research results. In recent years, interdisciplinary research in the field of neuroscience has expanded our knowledge about neurobiological correlates of mental processes and changes occurring in the brain due to therapeutic interventions. The studies are largely based on non-invasive brain imaging techniques, such as functional neuroimaging technologies of positron emission tomography (PET and functional magnetic resonance imaging (fMRI. The neuroscientific investigations of basic CBT hypotheses have shown that (i functional and non-functional behavior and experiences may be learned through lifelong learning, due to brain neuroplasticity that continues across the entire lifespan; (ii cognitive activity contributes to dysfunctional behavior and emotional experience through focusing, selective perception, memory and recall, and characteristic cognitive distortion; on a neurobiological level, there is a relationship between top-down and bottom-up regulation of unpleasant emotional states; and (iii cognitive activity may be changed, as shown by therapeutic success achieved by metacognitive and mindfulness techniques, which also have their neurobiological correlates in the changes occurring in the cortical and subcortical structures and endocrine and immune systems. The empirical research also shows that neurobiological changes occur after CBT in patients with arachnophobia, obsessive-compulsive disorder, panic disorder, social phobia, major depressive disorder and chronic fatigue syndrome.disorder and chronic fatigue syndrome.

  9. The Human-Canine Bond: Closer than Family Ties?

    Science.gov (United States)

    Barker, Sandra B.; Barker, Randolph T.

    1988-01-01

    Used Family Life Space Diagram to compare relationship between human family members with the human-canine relationship. Subjects were 29 dog enthusiasts, 66 typical pet owners, and 27 elementary school students with dogs. Results suggest that individuals may perceive their relationship with their pet dog as being as close as their relationship…

  10. 26 CFR 301.7701(b)-2 - Closer connection exception.

    Science.gov (United States)

    2010-04-01

    ...) Duration and nature of tax home. The tax home maintained by the alien individual must be in existence for... exception. (a) In general. An alien individual who meets the substantial presence test may nevertheless be considered a nonresident alien for the current year if the following conditions are satisfied— (1) The...

  11. A closer look at the RD and RD∗ anomalies

    International Nuclear Information System (INIS)

    Bardhan, Debjyoti; Byakti, Pritibhajan; Ghosh, Diptimoy

    2017-01-01

    The measurement of R D (R D ∗ ), the ratio of the branching fraction of B̄→Dτν̄ τ (B̄→D ∗ τν̄ τ ) to that of B̄→Dlν̄ l (B̄→D ∗ lν̄ l ), shows 1.9σ(3.3σ) deviation from its Standard Model (SM) prediction. The combined deviation is at the level of 4σ according to the Heavy Flavour Averaging Group (HFAG). In this paper, we perform an effective field theory analysis (at the dimension 6 level) of these potential New Physics (NP) signals assuming SU(3) C ×SU(2) L ×U(1) Y gauge invariance. We first show that, in general, R D and R D ∗ are theoretically independent observables and hence, their theoretical predictions are not correlated. We identify the operators that can explain the experimental measurements of R D and R D ∗ individually and also together. Motivated by the recent measurement of the τ polarisation in B̄→D ∗ τν̄ τ decay, P τ (D ∗ ) by the Belle collaboration, we study the impact of a more precise measurement of P τ (D ∗ ) (and a measurement of P τ (D)) on the various possible NP explanations. Furthermore, we show that the measurement of R D ∗ in bins of q 2 , the square of the invariant mass of the lepton-neutrino system, along with the information on τ polarisation and the forward-backward asymmetry of the τ lepton, can completely distinguish the various operator structures. We also provide the full expressions of the double differential decay widths for the individual τ helicities in the presence of all the 10 dimension-6 operators that can contribute to these decays.

  12. A closer look at temperature changes with remote sensing

    Science.gov (United States)

    Metz, Markus; Rocchini, Duccio; Neteler, Markus

    2014-05-01

    Temperature is a main driver for important ecological processes. Time series temperature data provide key environmental indicators for various applications and research fields. High spatial and temporal resolution is crucial in order to perform detailed analyses in various fields of research. While meteorological station data are commonly used, they often lack completeness or are not distributed in a representative way. Remotely sensed thermal images from polar orbiting satellites are considered to be a good alternative to the scarce meteorological data as they offer almost continuous coverage of the Earth with very high temporal resolution. A drawback of temperature data obtained by satellites is the occurrence of gaps (due to clouds, aerosols) that must be filled. We have reconstructed a seamless and gap-free time series for land surface temperature (LST) at continental scale for Europe from MODIS LST products (Moderate Resolution Imaging Sensor instruments onboard the Terra and Aqua satellites), keeping the temporal resolution of four records per day and enhancing the spatial resolution from 1 km to 250 m. Here we present a new procedure to reconstruct MODIS LST time series with unprecedented detail in space and time, at the same time providing continental coverage. Our method constitutes a unique new combination of weighted temporal averaging with statistical modeling and spatial interpolation. We selected as auxiliary variables datasets which are globally available in order to propose a worldwide reproducible method. Compared to existing similar datasets, the substantial quantitative difference translates to a qualitative difference in applications and results. We consider both our dataset and the new procedure for its creation to be of utmost interest to a broad interdisciplinary audience. Moreover, we provide examples for its implications and applications, such as disease risk assessment, epidemiology, environmental monitoring, and temperature anomalies. In the near future, aggregated derivatives of our dataset (following the BIOCLIM variable scheme) will be freely made online available for direct usage in GIS based applications.

  13. A closer look at overuse injuries in the pediatric athlete.

    Science.gov (United States)

    Stracciolini, Andrea; Casciano, Rebecca; Friedman, Hilary Levey; Meehan, William P; Micheli, Lyle J

    2015-01-01

    To examine male-female differences in pediatric overuse sports injuries. Cross-sectional epidemiological study. Tertiary level sports medicine division in a large academic pediatric medical center. Five percent probability sample of patients 5 to 17 years seen from January 1, 2000 to December 31, 2009. About 3813 charts reviewed. Final study cohort included 1614 patients. Nonlinear decomposition analysis of male-female differences in overuse injuries. Age, body mass index, history of previous injury, and activity type (contact/collision, team vs individual, "high overuse"). Females sustained approximately half of the total injuries. Fifty-two percent of the injuries were overuse, 61% to the lower extremity. A high proportion of tennis players, swimmers, dancers, track athletes, runners, gymnasts, and cheerleaders were seen for overuse injuries. Females sustained more overuse injuries versus males (63% and 40%, respectively). Males playing team sports have a 5.3 times higher likelihood of being seen for an overuse injury compared with males not playing team sports (P sport participation increased overuse injury odds by a factor of 10 for males versus 3.6 for females (P ≤ 0.01 for males and females). Forty-six percent of the male-female difference in overuse injuries could be attributed to sport/activity characteristics-contact/collision, team, and high overuse. A large proportion of the sex discrepancy in overuse injuries in this cohort was attributed to compositional differences in sports played. Future research is needed to investigate the independent effect of sex on risk for pediatric sports injuries. This study provides a unique analysis of male-female differences in pediatric sports injuries and is the first study to estimate the impact of the different characteristics (ie, collision, team, high overuse) of sports children play on overuse injuries sustained by young athletes. The findings will help guide future prevention efforts.

  14. A Closer Look at Acid-Base Olfactory Titrations

    Science.gov (United States)

    Neppel, Kerry; Oliver-Hoyo, Maria T.; Queen, Connie; Reed, Nicole

    2005-01-01

    Olfactory titrations using raw onions and eugenol as acid-base indicators are reported. An in-depth investigation on olfactory titrations is presented to include requirements for potential olfactory indicators and protocols for using garlic, onions, and vanillin as acid-base olfactory indicators are tested.

  15. CERN gets closer to the “quartier international”

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    Born under the auspices of UNESCO, raised in one of the world's most international cities, European by nature and global in attitude, CERN is well placed to catalyse the energies arising from the different international organisations in Geneva and beyond. A positive boost was given to the relations between them just a couple of years ago and it is now yielding fruits.   CERN has the concept laid down in its Convention: the Organization was founded to do fundamental science but its main goals include fostering education, peaceful collaboration and knowledge transfer to society. Hence, the large overlap with many other international organisations appears crystal clear. However, if you are in the Geneva region and you follow the “International Organisations” signposting, you do not end up at CERN… “Despite being in the same region and having several goals in common, until recently there was no structured framework for the relationships between CERN an...

  16. Sexual Harassment and Experiential Education Programs: A Closer Look.

    Science.gov (United States)

    Loeffler, T. A.

    Sexual harassment can be devastating and have tremendous impact on the emotional well-being, physical health, and vocational success of those who experience it. It is especially important for outdoor education program staff to proactively address sexual harassment because these programs often take place in remote locations that may make escape…

  17. Beyond generics: A closer look at hybrid and hierarchical governance

    NARCIS (Netherlands)

    R.F. Speklé (Roland)

    2001-01-01

    textabstractSamenvatting (summary in Dutch) 1. Het thema van dit proefschrift Een van de invloedrijkste theoretische stromingen binnen de institutionele economie is de benadering die bekend staat als Transaction Cost Economics (TCE). TCE is een theorie die een verklaring wil bieden voor de relatie

  18. Taking a Closer Look at Your Informational Writing Instruction

    Science.gov (United States)

    Beschorner, Beth; Hall, Anna H.

    2018-01-01

    When students write informational text, they have the opportunity to engage with meaningful topics, become curious about the world, learn domain-specific knowledge, and use academic vocabulary. Given the possibilities for learning through writing informational text, it is important for teachers to reflect on and improve their informational writing…

  19. A closer look at the management, revocation and compensation ...

    African Journals Online (AJOL)

    This article examines the sections dealing with the management and control and revocation powers given to the Governors of the state as well as the compensation sections for acquisition of land compulsorily acquired for overriding public interest. It ends up with looking at the proposed amendments, the sections that is ...

  20. A CLOSER LOOK AT THE MANAGEMENT, REVOCATION AND ...

    African Journals Online (AJOL)

    OLAWUYI

    The coming of the LUA automatically changed the norm and accepted .... This in effect led to recognition of both customary rights of ... The rent review panel recommended that land ownership should be vested in the ... I (1983) (action commenced in October 1960, appeal heard and retrial ordered by the Supreme Court in ...

  1. Get a Little Closer: Further Examination of Nonverbal Comforting Strategies.

    Science.gov (United States)

    Bullis, Connie; Horn, Charlotte

    1995-01-01

    Tests whether a set of nonverbal comforting strategies and their relationships with affective orientation and gender in previous research are generalizable to a broader sample. Concludes gender differences in affective orientation, diversity and number of strategies, and use of specific strategies were supported. Finds that females were more…

  2. IAS 16 Property, Plant and Equipment - A Closer Look

    OpenAIRE

    Muthupandian, K S

    2009-01-01

    The International Accounting Standards Committee issued the the International Accounting Standard 16 Property, Plant and Equipment. The objective of IAS 16 is to prescribe the accounting treatment for Property, Plant and Equipment (PPE) so that users of the financial statements can discern information about an entity's investment in its PPE and the changes in such investment. The principal issues in accounting for PPE are the recognition of the assets, the determination of their carrying amou...

  3. Design Management and Business in Europe: A Closer Look

    NARCIS (Netherlands)

    Kathryn Best; Darragh Murphy; Gert Kootstra

    2010-01-01

    It is often said that European companies must stop trying to compete on price and concentrate more on developing products and services that offer customers and users a high level of added value. Design is an indispensable tool for such development and innovation, and this is why the findings of this

  4. Thymic pathology and cardiac myxomas: Coincidence or a closer relationship?

    Science.gov (United States)

    Moraitis, Sotirios D; Agrafiotis, Apostolos C; Pappas, Dimitrios; Pothitakis, Chrysovalantis; Stergianni, Maria; Koukis, Ioannis

    2018-04-30

    Myxomas are the most common benign cardiac tumors and are located more frequently in the left atrium. In the literature there are cases describing the coexistence of thymic tumors and cardiac myxomas. In the case reported herein, during the resection of a cardiac myxoma, an enlarged thymus gland was encountered and resected. The histological exam revealed a thymic hyperplasia. The aim of this case study is to assess the need of conducting further studies in order to identify a common histological pathway between thymic lesions and cardiac myxomas. The diagnosis of a cardiac myxoma could justify a further workup of the anterior mediastinum in order not to overlook a lesion of thymic origin.

  5. Closer to Learning: Social Networks, Trust, and Professional Communities

    Science.gov (United States)

    Liou, Yi-Hwa; Daly, Alan J.

    2014-01-01

    Researchers, educators, and policymakers suggest the use of professional learning communities as one important approach to the improvement of teaching and learning. However, relatively little research examines the interplay of professional interactions (structural social capital) around instructional practices and key elements of professional…

  6. A closer look at non-decoupling D-Terms

    CERN Document Server

    Staub, Florian

    2016-01-01

    Non-Decoupling D-Terms are an attractive possibility to enhance the tree-level mass of the standard model like Higgs boson in supersymmetric models. We discuss here for the case of a new Abelian gauge group two effects usually neglected in literature: (i) the size of the additional radiative corrections to the Higgs mass due to the presence of the new gauge coupling, and (ii) the impact of gauge kinetic mixing. It is shown that both effects reduce to some extent the positive effect of the non-decoupling D-terms on the Higgs mass.

  7. As polar ozone mends, UV shield closer to equator thins

    Science.gov (United States)

    Reese, April

    2018-02-01

    Thirty years after nations banded together to phase out chemicals that destroy stratospheric ozone, the gaping hole in Earth's ultraviolet radiation shield above Antarctica is shrinking. But new findings suggest that at midlatitudes, where most people live, the ozone layer in the lower stratosphere is growing more tenuous—for reasons that scientists are struggling to fathom. In an analysis published this week, researchers found that from 1998 to 2016, ozone in the lower stratosphere ebbed by 2.2 Dobson units—a measure of ozone thickness—even as concentrations in the upper stratosphere rose by about 0.8 Dobson units. The culprit may be ozone-eating chemicals such as dichloromethane that break down within 6 months after escaping into the air.

  8. Microwave irradiation - a closer look at heating efficiencies

    NARCIS (Netherlands)

    Hoogenboom, R.; Wilms, T.F.A.; Schubert, U.S.

    2008-01-01

    Microwave irradn. is rapidly evolving into a common heat source in different areas of chem. including medicinal and org. chem. as well as polymer chem. The major advantages of the use of microwave irradn. are the often obsd. faster and cleaner reactions and sometimes changes in selectivity. Although

  9. The Oral Introduction to the Instructional Film: A Closer Look.

    Science.gov (United States)

    Arwady, Joseph W.

    1980-01-01

    Discusses reasons for an oral introduction to instructional films, types of oral introductions--i.e., substantive, attention-directing, anxiety-inducing, and advance organizers--and research related to these four areas. Recommendations for the use of the oral introduction are also offered. (RAO)

  10. A Closer Look: The American Taxpayer Relief Act of 2012

    Science.gov (United States)

    Balmer, Mary

    2013-01-01

    School districts may be affected by the American Taxpayer Relief Act of 2012 with regard to fixed assets management and education entities. The act avoids the scheduled increases to individual income tax rates for most Americans and extends a host of expired and expiring tax provisions for both individuals and businesses. The provisions described…

  11. Closer to nature interactive installation design for elderly with dementia

    NARCIS (Netherlands)

    Valk, C.A.L.; Lin, X.; Fijes, L.M.G.; Rauterberg, G.W.M.; Hu, J.

    2017-01-01

    Dementia is a serious degenerative neurological condition that affects cognition and memory, often accompanied with depression and anxiety. As explicit memory deteriorates, the implicit memory remains, so sensory stimulation and tangible solutions become increasingly important to people with

  12. NREL Research Pushes Perovskites Closer to Market | News | NREL

    Science.gov (United States)

    even get close-to the above-20% efficiencies dominated by silicon solar panels. NREL researcher Kai Zhu ; Perovskites have a couple of major benefits over silicon solar panels. The silicon technology requires a high as excellent semiconductors. This means perovskite panels are more flexible than rigid silicon panels

  13. Impact of replacement of conventional Recloser with PulseCloser

    OpenAIRE

    Olgert Metko; Rajmonda Bualoti; Engjell Zeqo

    2011-01-01

    Conventional recloser stresses the circuit with current fault every time they reclose into a fault. After clearing a fault, a conventional recloser simply recloses the interrupters to continuously test the presence of the fault. If the fault is still there, the interrupters are tripped again. Then, after a time delay, the interrupters are reclosed. During reclosing operation of Automatic Recloser, including the faster recloser one, powerful transient processes occurs and significant amount of...

  14. A closer look at non-decoupling D-terms

    Directory of Open Access Journals (Sweden)

    Florian Staub

    2016-07-01

    Full Text Available Non-decoupling D-terms are an attractive possibility to enhance the tree-level mass of the standard model like Higgs boson in supersymmetric models. We discuss here for the case of a new Abelian gauge group two effects usually neglected in literature: (i the size of the additional radiative corrections to the Higgs mass due to the presence of the new gauge coupling, and (ii the impact of gauge kinetic mixing. It is shown that both effects reduce to some extent the positive effect of the non-decoupling D-terms on the Higgs mass.

  15. PERSPECTIVE: Keeping a closer eye on fossil fuel CO2

    Science.gov (United States)

    Nelson, Peter F.

    2009-12-01

    Peter F Nelson The world is watching expectantly as the clock winds down towards the United Nations Climate Change Conference (COP15; http://en.cop15.dk/) to be held 7-18 December 2009 in Copenhagen. While most are now convinced of the need for a strong and concerted response to the climate challenge, the exact nature and extent of that response remains uncertain. There is evidence (Barnett 2009) that current estimates of emissions now exceed all but the most extreme emission scenarios developed by the Intergovernmental Panel on Climate Change (IPCC). If that increase in emissions persists then temperature increases of 4 °C by 2060 have been predicted (Barnett 2009). An inevitable result of the potential for such extreme climate change is to advance the need for multiple adaptation strategies to decision making about, for example, infrastructure, urban planning and forest management. These strategies need to do more than incremental adaptation (Barnett 2009); instead transformative approaches may be required to adapt. The timing of the response is also proving to be a critical determining factor in the effectiveness of global actions. Using a simple conceptual model of emissions, Vaughan and co-workers (Vaughan et al 2009) show that avoiding dangerous climate change is more effective if such action begins early. Early action is also more effective than acting more aggressively later (Vaughan et al 2009). Uncertainties, although reduced, are still significant in the science of climate change. The interactions between control of particulate air pollutants and climate change are particularly challenging (Arneth et al 2009, Shindell et al 2009) but many other uncertainties require continuing research. The scientific uncertainties are only one aspect of an intense interdisciplinary, political, economic and cultural dialogue. It is clear that political will, economic interest, target setting for emissions reductions, adaptation, technology and financing (Pan 2009) will all have a major influence on progress to an international agreement. It is important that the political challenges are not underestimated. Long-term observers of the negotiations necessary for global agreements (Inman 2009) are pessimistic about the chances for success at COP15, and argue that agreements between smaller groups of countries may be more effective. China and other developing countries clearly expect greater emission cuts by developed nations as a condition for a successful deal (Pan 2009). Conversely, the constraints on US climate policies are considerable, notably those imposed by fears that an international agreement that does not include equitable emission control measures for developing countries like China and India, will compromise the agreement and reduce its effectiveness (Skodvin and Andresen 2009). In this context the need for earlier, and more reliable, information on emissions is a high priority. Myhre and coworkers (Myhre et al 2009) provide an efficient method for calculating global carbon dioxide emissions from fossil fuel combustion by combining industry statistics with data from the Carbon Dioxide Information Analysis Center (CDIAC; http://cdiac.ornl.gov/). Recent analyses of carbon dioxide emission data show a worrying acceleration in emissions, beyond even the most extreme IPCC projections, but are based largely on the CDIAC which gives information about emissions released two to three years before real time (Canadell et al 2007, Raupach et al 2007). The approach used by Myhre et al (2009) uses BP annual statistics of fossil fuel consumption and has a much shorter lag, of the order of six months. Of significant concern is that their analysis of the data also reveals that the recent strong increase in fossil fuel CO2 is largely driven by an increase in emissions from coal, most significantly in China. By contrast, emissions from oil and gas continue to follow longer-term historical trends. Earlier and accurate data on CO2 emissions is important for a range of reasons. It allows comparison with the scenarios developed by the IPCC; uncertainties in emission scenarios are one of the major sources of uncertainties in temperature projections, particularly at longer time scales, where temperature projections are increasingly dependent on specific emission scenarios (IPCC 2007). There have also been recent suggestions (Le Quere et al 2007) of a weakening of the oceanic sink for CO2, and earlier information on emission pathways will be important for testing this hypothesis. Some observers (Levi 2009) believe that the best outcome from COP15 may be an agreement on measurement, reporting and verification. While this may seem like a modest ambition, progress in this area is essential to a successful climate change measure and to compliance with any international agreement. As Levi (2009) points out, `such verification will help make it more politically feasible to undertake similar emissions-cutting actions elsewhere, including in the United States'. The approach of Myhre et al is a very useful tool in such independent verification. References Arneth A, Unger N, Kulmala M and Andreae M O 2009 Clean the air, heat the planet? Science 326 672-3 Barnett A 2009 No easy way out Nature Reports Climate Change 3 128-9 Canadell J G, Le Quere C, Raupach M R, Field C B, Buitenhuis, E T, Ciais P, Conway T J, Gillett N P, Houghton R A and Marland G 2007 Contributions to accelerating atmospheric CO2 growth from economic activity, carbon intensity, and efficiency of natural sinks Proc. Natl Acad. Sci. USA 104 18866-70 Inman M 2009 The climate change game Nature Reports Climate Change 3 130-3 IPCC 2007 Climate Change 2007: Synthesis Report. Contribution of Working Groups I, II and III to the Fourth Assessment Report of the Intergovernmental Report on Climate Change (Geneva: IPCC) 104pp Le Quere C, Rodenbeck C, Buitenhuis E T, Conway T J, Langenfelds R, Gomez A, Labuschagne C, Ramonet M, Nakazawa T, Metzl N, Gillett N and Heimann M 2007 Saturation of the Southern Ocean CO2 sink due to recent climate change Science 316 1735-8 Levi M A 2009 Copenhagen's inconvenient truth: how to salvage the climate conference Foreign Affairs 92-103 Myhre G, Alterskjaer K and Lowe D 2009 A fast method for updating global fossil fuel carbon dioxide emissions Environ. Res. Lett. 4 034012 Pan J 2009 China expects leadership from rich nations Nature 461 1055 Raupach M R, Marland G, Ciais P, Le Quere C, Canadell J G, Klepper G and Field C B 2007 Global and regional drivers of accelerating CO2 emissions Proc. Natl Acad. Sci. USA 104 10288-93 Shindell D T, Faluvegi G, Koch D M, Schmidt G A, Unger N and Bauer S E 2009 Improved attribution of climate forcing to emissions Science 326 716-8 Skodvin T and Andresen S 2009 An agenda for change in US climate policies? Presidential ambitions and congressional powers Int. Environ. Agreements: Politics Law Econ. 9 263-80 Vaughan N E, Lenton T M and Shepherd J G 2009 Climate change mitigation: trade-offs between delay and strength of action required Climatic Change 96 29-43

  16. Officials discuss closer ties in new power plant project

    Index Scriptorium Estoniae

    2009-01-01

    Venemaa suursaadik Lätis Alexander Veshnyakov ütles, et kui Läti otsustab uue gaasielektrijaama rajada, siis Venemaa on valmis sellesse projekti investeerima. Läti Venemaa-suunaline eksport-import

  17. Ilves wants closer cooperation on cyber-crime

    Index Scriptorium Estoniae

    2011-01-01

    Washingtonis toimunud iga-aastasel Trilateraalse Komisjoni konverentsil kutsus president Toomas Hendrik Ilves NATOt ja Euroopa Liitu üles koostööle küberkaitse arendamisel. Töövisiit Ameerika Ühendriikidesse 07.04.2011 - 10.04.2011

  18. The Rise of Female Sterilization: A Closer Look at Colombia.

    Science.gov (United States)

    Folch, Beatriz M; Betstadt, Sarah; Li, Dongmei; Whaley, Natalie

    2017-09-01

    Objective In the 1970s, OCPs and IUDs were the most popular contraceptive methods in Colombia. According to data from the most recent Demographic and Health Survey (DHS), sterilization has become the most common form of birth control in Colombia. This study aims to examine the characteristics of Colombian women desiring long-acting contraception. Methods This study uses the 2005 and 2010 Colombian DHS dataset. Women who choose long-acting contraception were divided into those using female sterilization and those using long-acting reversible contraception (LARC). A multivariate logistic regression model was used to compare demographic and social determinants of contraceptive choice among reproductive age women seeking long-acting contraception between the years 2005 and 2010. Results Among women using a long-acting contraceptive method in 2010, compared to 2005, women were significantly more likely to be sterilized (1.14 OR, 95% CI 1.09-1.18) and less likely to use LARC (0.88 OR, 95% CI 0.85-0.92). Of women seeking long-acting contraception, those exposed to a family planning provider were less likely to undergo sterilization (0.54 OR, 95% CI 0.51-0.58) and more likely to use LARC (1.84 OR, 95% CI 1.73-1.96). When compared to all contraceptive users, younger women and women with less than two children were more likely to use LARC than sterilization. Conclusion Between 2005 and 2010, an increase in the proportion of contracepting women being sterilized in Colombia occurred. Our findings suggest that exposure to a family planning provider and appropriate contraceptive counseling appears to be key determinants of long-acting contraceptive choice. To improve use of long-acting, effective contraception, efforts should be made to increase access to family planning providers.

  19. Inaction inertia, regret, and valuation : A closer look

    NARCIS (Netherlands)

    Zeelenberg, Marcel; Nijstad, Bernard A.; van Putten, Marijke; van Dijk, Eric

    Inaction inertia is the phenomenon that one is not likely to act on an attractive opportunity after having bypassed an even more attractive opportunity. So far, all published work has assumed a causal role for the emotion regret in this effect. In a series of 5 experiments we found no support for

  20. IAS 1 Presentation of Financial Statements - A Closer Look

    OpenAIRE

    Muthupandian, K S

    2008-01-01

    The International Accounting Standards Committee issued the International Accounting Standard 1 Presentation of Financial Statements. The objective of IAS 1 is to prescribe the basis for presentation of general purpose financial statements (GPFS), to ensure comparability both with the entity's financial statements of previous periods and with the financial statements of other entities. The objective of GPFS is to provide information about the financial position, financial performance, and cas...

  1. Minnesota Kids: A Closer Look. 1996 Data Book.

    Science.gov (United States)

    Kids Count Minnesota, Minneapolis.

    Minnesota KIDS COUNT focuses on key risk indicators for children and describes the condition of children in each of Minnesota's 87 counties. According to this second annual report, another generation of children is at risk of growing up with decreasing resources, evidenced by increasing arrest rates for violent crimes and substantiated reports of…

  2. A Closer Examination of the Academic Benefits of AP

    Science.gov (United States)

    McKillip, Mary E. M.; Rawls, Anita

    2013-01-01

    The authors sought to better understand the relationship between students participating in the Advanced Placement (AP) program and subsequent performance on the Scholastic Aptitude Test (SAT). Focusing on students graduating from U.S. public high schools in 2010, the authors used propensity scores to match junior year AP examinees in 3 subjects to…

  3. Bringing Model Checking Closer to Practical Software Engineering

    CERN Document Server

    AUTHOR|(CDS)2079681; Templon, J A; Willemse, T.A.C.

    Software grows in size and complexity, making it increasingly challenging to ensure that it behaves correctly. This is especially true for distributed systems, where a multitude of components are running concurrently, making it dicult to anticipate all the possible behaviors emerging in the system as a whole. Certain design errors, such as deadlocks and race-conditions, can often go unnoticed when testing is the only form of verication employed in the software engineering life-cycle. Even when bugs are detected in a running software, revealing the root cause and reproducing the behavior can be time consuming (and even impossible), given the lack of control the engineer has over the execution of the concurrent components, as well as the number of possible scenarios that could have produced the problem. This is especially pronounced for large-scale distributed systems such as the Worldwide Large Hadron Collider Computing Grid. Formal verication methods oer more rigorous means of determining whether a system sat...

  4. A closer look at the tritanopic convergence point

    NARCIS (Netherlands)

    Walraven, P.L.

    1974-01-01

    On the basis of new experimental data of tritanopic vision the convergence centre for tritanopia has been redetermined, and has turned out to bex' = 0.1747,y' = 0.0060 in the Judd 1951-chromaticity diagram. A consequence of this determination is that the blue system is more sensitive than was

  5. A Closer Look at the Transcriptome of Staphylococcus aureus

    NARCIS (Netherlands)

    Smits, N.J.P.

    2012-01-01

    Tight regulation of genes upon changing environments is important in establishing and maintaining infections by pathogens. In Staphylococcus aureus, gene expression and particularly controlled expression of various groups of genes dependent on growth and environmental conditions is essential for

  6. A closer look: the complexities of dental biofilm

    OpenAIRE

    Costerton, J.W.; Stoodley, P.

    2003-01-01

    Biofilms are the collections of bacteria and other microorganisms that assemble on surfaces. They are widespread in nature and can colonize natural, nonliving hard surfaces such as river rocks, man-made surfaces like the concrete found in industrial pipelines, and even plant and animal surfaces and, of course, the teeth and gums.Within this broad definition, dental plaque falls into one of many types of different biofilms. Loosely adherent plaque and the denser, more firmly attached plaque ma...

  7. Ilves urges closer ties while in Austria / Ella Karapetyan

    Index Scriptorium Estoniae

    Karapetyan, Ella

    2010-01-01

    President Toomas Hendrik Ilvese ametlik visiit Austria Vabariiki 22.11.2010 - 24.11.2010. Eesti riigipea pidas kõne Austria Majanduskojas Eesti-Austria majandusfoorumil, kohtus Alam-Austria Liidumaa parlamendi presidendi Hanz Penz'i ning Austria presidendi Heinz Fischeriga. Presidentide kohtumisel räägiti EL-i laienemispoliitikast, energiajulgeoleku probleemidest, Euroopa naabruspoliitikast ja idapartnerlusest

  8. Isolated elders demonstration project : closer to home - a descriptive evaluation

    OpenAIRE

    Cusack, Sandra A.

    1996-01-01

    The purpose of this demonstration project is to support isolated elders through outreach. The goal is to get seniors "out of their homes" and back into the community, assisting them to make decisions and take action on their own behalf. The process involved training a group of volunteers to interview elders, using a mini-life review technique to encourage reminiscence. In listening to their stories, the volunteer's task was to discover the elder's needs and barriers to socialization, and to l...

  9. Teacher Education in Sub-Saharan Africa: Closer Perspectives

    Science.gov (United States)

    Griffin, Rosarii, Ed.

    2012-01-01

    In the drive to achieve universal primary education as one of the Millennium Development Goals, there is an increasing recognition of the urgency of focusing on teacher education to both meet the demand for more than one million qualified teachers required to achieve this goal within sub-Saharan Africa, as well as to combat the sometimes poor…

  10. Self-esteem: a closer look at clinical interventions.

    Science.gov (United States)

    Meisenhelder, J B

    1985-01-01

    Self-esteem, a positive regard for oneself, is a universal need for every human being and a key component in restoring and maintaining mental and physical health. Yet, this important concept is remarkably neglected in nursing literature and easily overlooked in clinical practice. This article examines the existing research on the antecedents of self-esteem and compiles a list of factors which can facilitate the nurse's therapeutic effect on her client's positive self-concept. From this list, specific nursing interventions are provided for raising and maintaining a client's self-esteem. Since the impact of nursing interventions varies with clinical circumstances, the nursing actions are correlated with their most effective health care settings. This article provides a global and practical approach to the enhancement of clients' self-esteem.

  11. An Evaluation of the Limited Contract Warrant Experiment at March AFB.

    Science.gov (United States)

    1986-09-01

    than $1,000, and these account for only 4.5% of the total dollars expended (23). Statistics for the entire Air Force reflect a similar situation. In FY...sent with the workbook for the person administering the course.(2 1:1) The subjects covered in the coursebook are: Introduction to Defense Small...7 course as statistics are maintained by each of the 112 chapters separately. (56) There are some private consultants who provide training in this

  12. Pediatric near-drowning events: do they warrant trauma team activation?

    Science.gov (United States)

    Chotai, Pranit N; Manning, Lisa; Eithun, Benjamin; Ross, Joshua C; Eubanks, James W; Hamner, Chad; Gosain, Ankush

    2017-05-15

    The purpose of this study was to determine the incidence of traumatic injuries, factors associated with mortality, and need for pediatric trauma surgery involvement for drowning and near-drowning events in children. An institutional review board-approved, retrospective chart review was performed at three American College of Surgeons-verified Pediatric Trauma Centers (2011-2014). Patients with International Classification of Diseases, Ninth Revision, codes or E-codes for fatal-nonfatal drowning, fall into water, accidental drowning, or submersion were included. Bivariate analysis using chi-square or Fisher exact test for nominal variables and Mann-Whitney U test for continuous variables was performed. A total of 363 patients (median 3.17 y [18 d-17 y]) met the inclusion criteria. Drowning sites included pool (81.5%), bathtub (12.9%), and natural water (5.2%). A witnessed fall or dive was reported in 34.9%, 57.9% did not fall or dive, and 7% had an unwitnessed event. Most patients did not undergo cervical spine (83%) or brain imaging (75.5%). Seven patients (1.92%) had associated soft tissue injuries. Two patients (0.006%) received surgical intervention (bronchoscopy and extracorporeal membrane oxygenation) within 24 h of presentation. Only 2.2% were admitted to the pediatric trauma service. The percentage of patients discharged home from the emergency department was 10.2%. Overall mortality was 12.4%. Factors associated with mortality included transfer from outside hospital (P = 0.016), presence of hypothermia on arrival (P drowning in a pool (P = 0.013), or undergoing brain cooling at admission (P = 0.011). This is the largest reported series of pediatric near-drowning events. Only rarely did patients require immediate surgical attention and the majority were admitted to nonsurgical services. These data suggest that routine pediatric trauma surgery service involvement in patients with near-drowning events may be unnecessary. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Radiotherapy for esthesioneuroblastoma: is elective nodal irradiation warranted in the multimodality treatment approach?

    Science.gov (United States)

    Noh, O Kyu; Lee, Sang-wook; Yoon, Sang Min; Kim, Sung Bae; Kim, Sang Yoon; Kim, Chang Jin; Jo, Kyung Ja; Choi, Eun Kyung; Song, Si Yeol; Kim, Jong Hoon; Ahn, Seung Do

    2011-02-01

    The role of elective nodal irradiation (ENI) in radiotherapy for esthesioneuroblastoma (ENB) has not been clearly defined. We analyzed treatment outcomes of patients with ENB and the frequency of cervical nodal failure in the absence of ENI. Between August 1996 and December 2007, we consulted with 19 patients with ENB regarding radiotherapy. Initial treatment consisted of surgery alone in 2 patients; surgery and postoperative radiotherapy in 4; surgery and adjuvant chemotherapy in 1; surgery, postoperative radiotherapy, and chemotherapy in 3; and chemotherapy followed by radiotherapy or concurrent chemoradiotherapy in 5. Five patients did not receive planned radiotherapy because of disease progression. Including 2 patients who received salvage radiotherapy, 14 patients were treated with radiotherapy. Elective nodal irradiation was performed in 4 patients with high-risk factors, including 3 with cervical lymph node metastasis at presentation. Fourteen patients were analyzable, with a median follow-up of 27 months (range, 7-64 months). The overall 3-year survival rate was 73.4%. Local failure occurred in 3 patients (21.4%), regional cervical failure in 3 (21.4%), and distant failure in 2 (14.3%). No cervical nodal failure occurred in patients treated with combined systemic chemotherapy regardless of ENI. Three cervical failures occurred in the 4 patients treated with ENI or neck dissection (75%), none of whom received systemic chemotherapy. ENI during radiotherapy for ENB seems to play a limited role in preventing cervical nodal failure. Omitting ENI may be an option if patients are treated with a combination of radiotherapy and chemotherapy. Copyright © 2011 Elsevier Inc. All rights reserved.

  14. Paranormal phenomena in the medical literature sufficient smoke to warrant a search for fire.

    Science.gov (United States)

    Bobrow, Robert S

    2003-06-01

    Paranormal phenomena - events that cannot be explained by existing science - are regularly reported in medicine. Surveys have shown that a majority of the population of the United States and Great Britain hold at least one paranormal belief. Information was retrieved by MEDLINE searches using keywords 'paranormal' and 'psychic', and from the author's own collection. Reports are predominantly by physicians, and from peer-reviewed, MEDLINE-indexed literature. This is a representative sample, as there is no database for paranormal medical phenomena. Presented and discussed are: a case of systemic lupus erythematosis ameliorated by witchcraft; an analysis of studies on distant healing; acupuncture, as a bridge between what is now accepted but recently would have been deemed paranormal; a carefully-done study of a psychic; auditory hallucinations informing a patient, correctly, that she had a brain tumor; two nearly-identical lay press reports of self-predicted death; lycanthropy (the delusion of being an animal); the development of Carl Jung's collective unconscious; hypnosis - still questioned despite documented therapeutic benefit, and a well-researched report of a person speaking a foreign language, apparently unlearned (xenoglossy) while hypnotized; and multiple examples of children who spout the details of the life of an unknown, deceased person. The inability of existing paradigms to explain these observations does not negate them; rather, it elucidates a need for more research.

  15. Hypothyroidism in adults. Levothyroxine if warranted by clinical and laboratory findings, not for simple TSH elevation.

    Science.gov (United States)

    2015-10-01

    Hypothyroidism is a common disorder due to inadequate thyroid hormone secretion. When a patient has signs and symptoms suggestive of hypothyroidism, how is it determined whether thyroid hormone replacement therapy will have a favourable harm-benefit balance? How should treatment be managed? To answer these questions, we conducted a review of the literature using the standard Prescrire methodology. The symptoms of hypothyroidism are due to slow metabolism (constipation, fatigue, sensitivity to cold, weight gain, etc.) and to polysaccharide accumulation in certain tissues, leading to hoarseness, eyelid swelling, etc. A blood TSH concentration of less than 4 or 5 mlU/L rules out peripheral hypothyroidism. TSH levels increase with age. Between 30% and 60% of high TSH levels are not confirmed on a second blood test. In overt hypothyroidism, the TSH level is high and the free T4 (thyroxine) level is low. Most of these patients are symptomatic. So-called subclinical hypothyroidism, which is rarely symptomatic, is characterised by high blood TSH levels and normal free T4 levels. The natural history of hypothyroidism depends on its cause. In chronic autoimmune thyroiditis, the most common form seen in rich countries, hypothyroidism generally worsens over time. However, other situations can lead to transient hypothyroidism that may last several weeks or months. Subclinical hypothyroidism, as the name implies, is usually asymptomatic. The risk of progression to overt hypothyroidism is about 3% to 4% per year overall but increases with the initial TSH level. Treatment guidelines are mainly based on physiological and pharmacological considerations and generally recommend levothyroxine therapy. The adverse effects of levothyroxine are signs of thyrotoxicosis in case of overdose (tachycardia, tremor, sweating, etc.). Even a slight overdose carries a risk of osteoporotic fractures and atrial fibrillation, especially in the elderly. In young adults, levothyroxine is usually started at a dose of about 1.5 microg/kg per day, taken on an empty stomach. Elderly patients and those with coronary artery disease should start at a lower dose: 12.5 to 50 microg per day. Treatment monitoring is based mainly on blood TSH assay. Dose adjustment should only be considered after 6 to 12 weeks, given the long half-life of levothyroxine. Certain drugs, such as iron and calcium, reduce the gastrointestinal absorption of levothyroxine. Enzyme inducers reduce its efficacy. In 2015, there is no robust evidence that levothyroxine therapy has any tangible benefit in patients with subclinical hypothyroidism. Some practice guidelines recommend treatment when the TSH level is above 10 mIU/L, or sometimes trial treatment for a few months for patients with symptoms suggestive of hypothyroidism. In practice, replacement therapy is needed for patients with overt hypothyroidism and a blood TSH concentration above 10 mIU/L. The main challenge is to recognise transient hypothyroidism, which does not require life-long treatment. When the TSH is only slightly elevated, there is a risk of attributing non-specific symptoms to an abnormal laboratory result and prescribing unnecessary treatment. Watchful waiting is an alternative to routine levothyroxine prescription in case of TSH elevation.

  16. Patient attributes warranting consideration in clinical practice guidelines, health workforce planning and policy

    Directory of Open Access Journals (Sweden)

    Segal Leonie

    2011-09-01

    Full Text Available Abstract Background In order for clinical practice guidelines (CPGs to meet their broad objective of enhancing the quality of care and supporting improved patient outcomes, they must address the needs of diverse patient populations. We set out to explore the patient attributes that are likely to demand a unique approach to the management of chronic disease, and which are crucial if evidence or services planning is to reflect clinic populations. These were incorporated into a new conceptual framework; using diabetes mellitus as an exemplar. Methods The patient attributes that informed the framework were identified from CPGs, the diabetes literature, an expert academic panel, and two cross-disciplinary panels; and agreed upon using a modified nominal group technique. Results Full consensus was reached on twenty-four attributes. These factors fell into one of three themes: (1 type/stage of disease, (2 morbid events, and (3 factors impacting on capacity to self-care. These three themes were incorporated in a convenient way in the workforce evidence-based (WEB model. Conclusions While biomedical factors are frequently recognised in published clinical practice guidelines, little attention is given to attributes influencing a person's capacity to self-care. Paying explicit attention to predictable threats to effective self-care in clinical practice guidelines, by drawing on the WEB model, may assist in refinements that would address observed disparities in health outcomes across socio-economic groups. The WEB model also provides a framework to inform clinical training, and health services and workforce planning and research; including the assessment of healthcare needs, and the allocation of healthcare resources.

  17. Twenty Years of Brassinosteroids : Steroidal Plant Hormones Warrant Better Crops for the XXI Century

    NARCIS (Netherlands)

    Khripach, V.; Zhabinskii, V.; Groot, de C.P.G.M.

    2000-01-01

    The discovery of brassinosteroids (BS) just over 20 years ago opened a new era in studies of bio-regulation in living organisms. Previously, the only known role of steroids as hormones was in animals and fungi; now a steroidal hormone in plants had been added. Progress in brassinosteroid research

  18. An Attitude Survey Analysis of CONUS Air Force Jet Propulsion Technicians Towards the Warranted Tool Program.

    Science.gov (United States)

    1983-09-01

    34 eN #0 R CC "B N "C "w "D C NO" NCC NCO3814 "" NEtV U A" "I"e0 R ""A e H" NO" NO" e" " " o񓼕.91 CC "E3" 34 NC" "B" C"DT NCTM CAN NfDe N[N C3N NBC

  19. Three Pervasive Presuppositions about Human Life and Ethics Strongly Warrant Analysis

    NARCIS (Netherlands)

    Miller, Lantz E.

    2017-01-01

    Common philosophical discussions concerning the ethics of human interaction with the biosphere and universe have been significantly informed by certain presuppositions: (1) nature is conquerable; (2) human cultural and social (contrasted with moral) progress is somewhat like a thing, beyond human

  20. 32 CFR Appendix D to Part 275 - Obtaining Access By Search Warrant

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) MISCELLANEOUS OBTAINING INFORMATION FROM FINANCIAL INSTITUTIONS: RIGHT TO FINANCIAL PRIVACY ACT... of Criminal Procedure. B. Unless a delay of notice has been obtained under provisions of Appendix H... following purpose: [state purpose]. You may have rights under the Right to Financial Privacy Act of 1978.” C...

  1. Hepatic pseudoaneurysm after traumatic liver injury; is CT follow-up warranted?

    DEFF Research Database (Denmark)

    Østerballe, Lene; Helgstrand, Frederik; Axelsen, Thomas

    2014-01-01

    INTRODUCTION: Hepatic pseudoaneurysm (HPA) is a rare complication after liver trauma, yet it is potentially fatal, as it can lead to sudden severe haemorrhage. The risk of developing posttraumatic HPA is one of the arguments for performing follow-up CT of patients with liver injuries. The aim...... no treatment failures. There was no correlation between the severity of the liver injury and development of HPA. 5 out of 7 patients were asymptomatic and would have been discharged without treatment if the protocol did not include a default follow-up CT. CONCLUSIONS: In conclusion, this study shows that HPA...

  2. Isolated metastasis of colon cancer to the scapula: is surgical resection warranted?

    Directory of Open Access Journals (Sweden)

    Onesti Jill K

    2011-10-01

    Full Text Available Abstract Background Distant metastases from colon cancer spread most frequently to the liver and the lung. Risk factors include positive lymph nodes and high grade tumors. Isolated metastases to the appendicular skeleton are very rare, particularly in the absence of identifiable risk factors. Case report The patient was a 55 year old male with no previous personal or family history of colon cancer. Routine screening revealed a sigmoid adenocarcinoma. He underwent resection with primary anastomosis and was found to have Stage IIA colon cancer. He declined chemotherapy as part of a clinical trial, and eight months later was found to have an isolated metastasis in his right scapula. This was treated medically, but grew to 12 × 15 cm. The patient underwent a curative forequarter amputation and is now more than four years from his original colon surgery. Discussion Stage IIA colon cancers are associated with a high five year survival rate, and chemotherapy is not automatically given. If metastases occur, they are likely to arise from local recurrence or follow lymphatic dissemination to the liver or lungs. Isolated skeletal metastases are quite rare and are usually confined to the axial skeleton. To our knowledge, this is the first reported case of an isolated scapular metastasis in a patient with node negative disease. The decision to treat the recurrence with radiation and chemotherapy did not reduce the tumor, and a forequarter amputation was eventually required. Conclusion This case highlights the importance of adequately analyzing the stage of colon cancer and offering appropriate treatment. Equally important is the early involvement of a surgeon in discussing the timing of the treatment for recurrence. Perhaps if the patient had received chemotherapy or earlier resection, he could have been spared the forequarter amputation. The physician must also be aware of the remote possibility of an unusual presentation of metastasis in order to pursue timely work up.

  3. Right-Turn Traffic Volume Adjustments in Traffic Signal Warrant Analysis

    Science.gov (United States)

    2015-01-01

    To accomplish this research, a comprehensive literature review of existing guidelines and findings based on national and local studies was conducted. Ultimately, guidelines for consistent application for adjusting right-turn traffic volumes were deve...

  4. Developing Air Defense Artillery Warrant Officers Cognitive Skills: An Analysis of Training Needs

    Science.gov (United States)

    2018-02-01

    Northrop Grumman Corporation 3565 Macon Road Columbus, GA 31907 8. PERFORMING ORGANIZATION REPORT NUMBER...coordinating the activities of enhanced operators for the maintenance of computers, commercial off the shelf and common hardware and software including...contingency missions. They advise the commander on capabilities and limitations of the AMD system. They supervise maintenance of equipment in AMD units as

  5. Do ultra-orphan medicinal products warrant ultra-high prices? A review

    Directory of Open Access Journals (Sweden)

    Picavet E

    2013-06-01

    Full Text Available Eline Picavet,1 David Cassiman,2 Steven Simoens1 1Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium; 2Department of Hepatology, University Hospital Leuven, Leuven, Belgium Abstract: Ultra-orphan medicinal products (ultra-OMPs are intended for the treatment, prevention, or diagnosis of ultra-rare diseases, ie, life-threatening or chronically debilitating diseases that affect less than one per 50,000 individuals. Recently, high prices for ultra-OMPs have given rise to debate on the sustainability and justification of these prices. The aim of this article is to review the international scientific literature on the pricing of ultra-OMPs and to provide an overview of the current knowledge on the drivers of ultra-OMP pricing. The pricing process of ultra-OMPs is a complex and nontransparent issue. Evidence in the literature seems to indicate that ultra-OMPs are priced according to rarity and what the manufacturer believes the market will bear. Additionally, there appears to be a trend between the price of an ultra-OMP and the number of available alternatives. Patients, third-party payers, and pharmaceutical companies could benefit from more transparent pricing strategies. With a view to containing health care costs, it is likely that cost-sharing strategies, such as performance-based risk sharing arrangements, will become increasingly more important. However, it is vital that any measures for price control are consistent with the intended goals of the incentives to promote the development of new OMPs. Ideally, a balance must be struck between attaining affordable prices for ultra-OMPs and securing a realistic return on investment for the pharmaceutical industry. Keywords: ultra-orphan medicinal product, ultra-rare disease, pricing

  6. Life cycle analysis of organic tandem solar cells: When are they warranted?

    DEFF Research Database (Denmark)

    Espinosa Martinez, Nieves; Krebs, Frederik C

    2014-01-01

    in their making when compared with the single junction solar cell has to be justified and compensated by a higher efficiency. A central question to ask is how much energy you need to invest in a system in order for it to produce energy and return the investment at least once and preferably a number of times....... As an initial investigation into the potential viability of the tandem or multi-junction approach we have engaged in a detailed analysis based on the manufacturing energy for each step within the tandem module supply chain for full ambient processing of thin flexible polymer tandem solar cells prepared entirely...

  7. Habits of cell phone usage and sperm quality - does it warrant attention?

    Science.gov (United States)

    Zilberlicht, Ariel; Wiener-Megnazi, Zofnat; Sheinfeld, Yulia; Grach, Bronislava; Lahav-Baratz, Shirly; Dirnfeld, Martha

    2015-09-01

    Male infertility constitutes 30-40% of all infertility cases. Some studies have shown a continuous decline in semen quality since the beginning of the 20th century. One postulated contributing factor is radio frequency electromagnetic radiation emitted from cell phones. This study investigates an association between characteristics of cell phone usage and semen quality. Questionnaires accessing demographic data and characteristics of cell phone usage were completed by 106 men referred for semen analysis. Results were analysed according to WHO 2010 criteria. Talking for ≥1 h/day and during device charging were associated with higher rates of abnormal semen concentration (60.9% versus 35.7%, P cell phone usage may bear adverse effects on sperm concentration. Investigation using large-scale studies is thus needed. Copyright © 2015 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  8. 26 CFR 1.1504-4 - Treatment of warrants, options, convertible obligations, and other similar interests.

    Science.gov (United States)

    2010-04-01

    ... the option in absolute terms and in relation to the fair market value of the stock or the exercise... the option is subject (e.g., a public offering of the issuing corporation's stock or reaching a... income. It is anticipated that P, S, and T will continue their earnings histories for several more years...

  9. Detecting and developing youth athlete potential: different strokes for different folks are warranted.

    Science.gov (United States)

    Suppiah, Haresh T; Low, Chee Yong; Chia, Michael

    2015-07-01

    Sport talent identification and development (TI and TD) in youth continues to attract strong interest among coaches, sport scientists and sport administrators. TI for sport in youth with the anticipation of future elite level sport achievement is both an art and a science, and is strongly influenced by within athlete and extraneous-to-athlete factors (ecosystem of support or the lack of). The returns from investment on current TI and TD models of sport in youth are subpar in that few continue in the sport to achieve podium positions at the elite sport level in adulthood. Why, where and how one succeeds in sport, and what that success means to the athlete and stakeholders are dependent on the culture and context of the country. We advocate harnessing the power of sport to help in youth development, to be holistic in its nurturance, to allow for individual idiosyncratic expressions of the athletes, to provide for talent transfer across sport, and to facilitate key stakeholders to 'join' hands to work for the common interest and understanding for as many youth and adults so as to provide them with opportunities through support and coaching to compete at the different levels of competition in sport. Governments, policy makers and administrators of sport must decide, within their specific circumstances, if TI and TD in sport in youth is serving a meaningful purpose and is a viable return on investment; in short, is it mission possible or is it… a quest for the Holy Grail for a podium finish in elite level sport competition? Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  10. Adverse pathology and undetectable ultrasensitive prostate-specific antigen after radical prostatectomy: is adjuvant radiation warranted?

    Science.gov (United States)

    Simon, Ross M; Howard, Lauren E; Freedland, Stephen J; Aronson, William J; Terris, Martha K; Kane, Christopher J; Amling, Christopher L; Cooperberg, Matthew R; Vidal, Adriana C

    2016-06-01

    To determine if men with adverse pathology but undetectable ultrasensitive (<0.01 ng/mL) PSA are at high-risk for biochemical recurrence (BCR), or if there is a subset of patients at low-risk for whom the benefit of adjuvant radiation therapy might be limited. We evaluated 411 patients treated with RP from 2001 to 2013 without adjuvant radiation who had an undetectable (<0.01 ng/mL) PSA level after RP but with adverse pathology [positive surgical margins (PSMs), extraprostatic extension (EPE), and/or seminal vesicle invasion (SVI)]. Multivariable Cox regression analyses tested the relationship between pathological characteristics and BCR to identify groups of men at highest risk of early BCR. On multivariable analysis, only pathological Gleason 7 (4 + 3), Gleason ≥8, and SVI independently predicted BCR (P = 0.019, P < 0.001, and P = 0.001, respectively), although on two-way analysis men with Gleason 7 (4 + 3) did not have significantly higher rates of BCR compared with patients with Gleason ≤6 (log-rank, P = 0.074). Men with either Gleason ≥8 (with PSMs or EPE) or SVI (15% of the cohort) defined a high-risk group vs men without these characteristics (3-year BCR risk of 50.4% vs 11.9%, log-rank, P < 0.001). Among men with adverse pathology but an undetectable (<0.01 ng/mL) PSA level after RP, the benefits of adjuvant radiation are probably limited except for men with Gleason 8-10 (with PSMs or EPE) or SVI who are at high-risk of early BCR. © 2015 The Authors BJU International © 2015 BJU International Published by John Wiley & Sons Ltd.

  11. Expeditionary Forensic Support to Joint Force Commanders: What Changes or Considerations are Warranted?

    Science.gov (United States)

    2012-04-10

    builders . Human Intelligence (HUMINT) and Signals Intelligence (SIGINT) could then also be prioritized and employed accordingly for optimal 8...responsibility for digital and multimedia forensics, and DIA responsibility for forensic intelligence activities and programs.31 The Army is also currently...aligning functional oversight of Forensics, Biometrics, Law Enforcement, Detainee Operations, and Physical Security 11 under one overarching

  12. Symmetry warrants rational cooperation by co-action in Social Dilemmas.

    Science.gov (United States)

    Sasidevan, V; Sinha, Sitabhra

    2015-08-12

    Is it rational for selfish individuals to cooperate? The conventional answer based on analysis of games such as the Prisoners Dilemma (PD) is that it is not, even though mutual cooperation results in a better outcome for all. This incompatibility between individual rationality and collective benefit lies at the heart of questions about the evolution of cooperation, as illustrated by PD and similar games. Here, we argue that this apparent incompatibility is due to an inconsistency in the standard Nash framework for analyzing non-cooperative games and propose a new paradigm, that of the co-action equilibrium. As in the Nash solution, agents know that others are just as rational as them and taking this into account lead them to realize that others will independently adopt the same strategy, in contrast to the idea of unilateral deviation central to Nash equilibrium thinking. Co-action equilibrium results in better collective outcomes for games representing social dilemmas, with relatively "nicer" strategies being chosen by rational selfish individuals. In particular, the dilemma of PD gets resolved within this framework, suggesting that cooperation can evolve in nature as the rational outcome even for selfish agents, without having to take recourse to additional mechanisms for promoting it.

  13. Does prospect theory warrant a paradigm shift in the economics of risk?

    Directory of Open Access Journals (Sweden)

    PL Mohapi

    2014-07-01

    Full Text Available This paper assesses whether a paradigm shift should be made from expected utility framework to prospect theory framework – in the economics of choice under risk. A brief overview of the subject is outlined, starting with expected utility theory and noting its descriptive limitations. Proposed theories to make up for these limitations is also provided. Prospect theory emerged as the most serious challenger to expected utility theory. A review of some descriptive predictions of prospect theory, suggests that there is no scientific reason why expected utility should not be ousted from dominance by prospect theory. The shift to prospect theory however is not without costs. Conceptual complexities and non-universality of application associated with prospect theory should be embraced with the shift while not entirely abandoning expected utility theory.

  14. Limitations of metformin use in patients with kidney disease: are they warranted?

    Science.gov (United States)

    Vasisht, K P; Chen, S-C; Peng, Y; Bakris, G L

    2010-12-01

    To show that metformin, one of the most widely used agents, is contraindicated in patients with diabetes having chronic kidney disease (CKD) (i.e. serum creatinine >1.5 mg/dl) secondary to fear of lactic acidosis. The overall incidence of lactic acidosis is estimated at an upper limit of eight cases per 100 000 patient-years. We evaluated metformin use in two cohorts, one from the University of Chicago Diabetes Center and the other from National Health and Nutrition Examination Survey (NHANES) 1999-2006. Estimated glomerular filtration rate (eGFR) was calculated using the re-expressed Modification of Diet in Renal Disease (MDRD) Study equation and compared to serum creatinine. We hypothesized that metformin is used in patients with undetected advanced CKD (i.e. serum creatinine is ≥1.5 mg/dl). A chi-squared test was used to compare per cent differences of metformin use across demographic variables and eGFR in the NHANES cohort. At the University of Chicago Diabetes Center, 36 of 234 (15.3%) patients with an eGFR of metformin. Data from NHANES, age >18 years and eGFR metformin. We conclude that metformin utilization occurs with a higher frequency than predicted by serum creatinine in people with eGFR <60 ml/min/1.73 m(2) . Given the very low incidence of lactic acidosis, the recommendation should be changed to reflect eGFR cut-off values rather than serum creatinine. © 2010 Blackwell Publishing Ltd.

  15. Occurrence of DNET and other brain tumors in Noonan syndrome warrants caution with growth hormone therapy.

    Science.gov (United States)

    McWilliams, Geoffrey D; SantaCruz, Karen; Hart, Blaine; Clericuzio, Carol

    2016-01-01

    Noonan syndrome (NS) is an autosomal dominant developmental disorder caused by mutations in the RAS-MAPK signaling pathway that is well known for its relationship with oncogenesis. An 8.1-fold increased risk of cancer in Noonan syndrome has been reported, including childhood leukemia and solid tumors. The same study found a patient with a dysembryoplastic neuroepithelial tumor (DNET) and suggested that DNET tumors are associated with NS. Herein we report an 8-year-old boy with genetically confirmed NS and a DNET. Literature review identified eight other reports, supporting the association between NS and DNETs. The review also ascertained 13 non-DNET brain tumors in individuals with NS, bringing to 22 the total number of NS patients with brain tumors. Tumor growth while receiving growth hormone (GH) occurred in our patient and one other patient. It is unknown whether the development or progression of tumors is augmented by GH therapy, however there is concern based on epidemiological, animal and in vitro studies. This issue was addressed in a 2015 Pediatric Endocrine Society report noting there is not enough data available to assess the safety of GH therapy in children with neoplasia-predisposition syndromes. The authors recommend that GH use in children with such disorders, including NS, be undertaken with appropriate surveillance for malignancies. Our case report and literature review underscore the association of NS with CNS tumors, particularly DNET, and call attention to the recommendation that clinicians treating NS patients with GH do so with awareness of the possibility of increased neoplasia risk. © 2015 Wiley Periodicals, Inc.

  16. 78 FR 20717 - Endangered and Threatened Wildlife and Plants; Proposed Endangered, Threatened, and Not Warranted...

    Science.gov (United States)

    2013-04-05

    ...). Although indirect age validation studies for S. lewini are still inconclusive, bomb radiocarbon and calcein... the ESA: Northwest Atlantic and Gulf of Mexico (NW Atlantic & GOM DPS); Central and Southwest Atlantic... States (from New Jersey to Florida) to Brazil, including the Gulf of Mexico and Caribbean Sea. In the...

  17. Transforming Warrant Officer Career College Instructor Assessment for the Army Learning Model

    Science.gov (United States)

    2014-09-01

    Career College (WOCC) to reflect the Army Learning Model (ALM)’s emphasis on adult pedagogical approaches. An instructor guide was also developed to...and digital communications, building of effective relationships through interpersonal tact, influence, and communication. • Critical thinking and...students to learn. Foster respect and rapport in the instructor-student relationship and the student-student relationship . Encourage student

  18. 28 CFR 2.47 - Warrant placed as a detainer and dispositional review.

    Science.gov (United States)

    2010-07-01

    ... notified of his right to request counsel under the provisions of § 2.48(b) to assist him in completing this... original sentence is not interrupted by a new conviction (e.g., YCA; NARA; Mexican or Canadian treaty cases...

  19. Approach to the Pediatric Patient with Graves’ Disease: When Is Definitive Therapy Warranted?

    Science.gov (United States)

    2011-03-01

    in children Signs Symptoms Goiter Hyperactivity Tachycardia Palpitations Weight loss Sleep disturbance Heat intolerance Fatigue Tremor Poor school...service for reeval-uation of Graves’ disease (GD). She had been diag- nosed with hyperthyroidism 3 yr earlier and treated with methimazole (MMI) titrated...to secondhand smoke. On physical examination, the patient had a heart rate of 105 beats per minute, blood pressure of 114/55 mm Hg, weight of 61 kg

  20. Radiotherapy for Esthesioneuroblastoma: Is Elective Nodal Irradiation Warranted in the Multimodality Treatment Approach?

    International Nuclear Information System (INIS)

    Noh, O Kyu; Lee, Sang-wook; Yoon, Sang Min; Kim, Sung Bae; Kim, Sang Yoon; Kim, Chang Jin; Jo, Kyung Ja; Choi, Eun Kyung; Song, Si Yeol; Kim, Jong Hoon; Ahn, Seung Do

    2011-01-01

    Purpose: The role of elective nodal irradiation (ENI) in radiotherapy for esthesioneuroblastoma (ENB) has not been clearly defined. We analyzed treatment outcomes of patients with ENB and the frequency of cervical nodal failure in the absence of ENI. Methods and Materials: Between August 1996 and December 2007, we consulted with 19 patients with ENB regarding radiotherapy. Initial treatment consisted of surgery alone in 2 patients; surgery and postoperative radiotherapy in 4; surgery and adjuvant chemotherapy in 1; surgery, postoperative radiotherapy, and chemotherapy in 3; and chemotherapy followed by radiotherapy or concurrent chemoradiotherapy in 5. Five patients did not receive planned radiotherapy because of disease progression. Including 2 patients who received salvage radiotherapy, 14 patients were treated with radiotherapy. Elective nodal irradiation was performed in 4 patients with high-risk factors, including 3 with cervical lymph node metastasis at presentation. Results: Fourteen patients were analyzable, with a median follow-up of 27 months (range, 7-64 months). The overall 3-year survival rate was 73.4%. Local failure occurred in 3 patients (21.4%), regional cervical failure in 3 (21.4%), and distant failure in 2 (14.3%). No cervical nodal failure occurred in patients treated with combined systemic chemotherapy regardless of ENI. Three cervical failures occurred in the 4 patients treated with ENI or neck dissection (75%), none of whom received systemic chemotherapy. Conclusions: ENI during radiotherapy for ENB seems to play a limited role in preventing cervical nodal failure. Omitting ENI may be an option if patients are treated with a combination of radiotherapy and chemotherapy.

  1. Focal thyroid incidentalomas identified with whole-body FDG-PET warrant further investigation.

    LENUS (Irish Health Repository)

    Prichard, R S

    2012-02-01

    Fluorodeoxyglucose (FDG) whole body positron emission computed tomography (PET-CT) detects clinically occult malignancy. The aim of this study was to assess the prevalence and significance of focal thyroid 18F - fluorodeoxyglucose uptake. A retrospective review of all patients who had FDG PET-CT examinations, in a single tertiary referral centre was performed. PET scan findings and the final pathological diagnosis were collated. 2105 scans were reviewed. Focal uptake was identified in 35 (1.66%) patients. Final surgical histology was available on eight patients, which confirmed papillary carcinoma in four (20%) patients and lymphoma and metastatic disease in two patients respectively. This gave an overall malignancy rate in focal thyroid uptake of at least 33%. Thyroid incidentalomas occurred with a frequency of 2.13%, with an associated malignancy rate of at least 33% in focal thyroid uptake. The high malignancy rate associated with focal thyroid uptake mandates further investigation in medically fit patients.

  2. Transcatheter Arterial Embolization for Upper Gastrointestinal Nonvariceal Hemorrhage: Is Empiric Embolization Warranted?

    Energy Technology Data Exchange (ETDEWEB)

    Arrayeh, Elnasif; Fidelman, Nicholas, E-mail: nicholas.fidelman@ucsf.edu; Gordon, Roy L.; LaBerge, Jeanne M.; Kerlan, Robert K. [University of California San Francisco, Department of Radiology (United States); Klimov, Alexander; Bloom, Allan I. [Hadassah Hospital, Department of Radiology (Israel)

    2012-12-15

    Purpose: To determine whether transcatheter arterial embolization performed in the setting of active gastric or duodenal nonvariceal hemorrhage is efficacious when the bleeding source cannot be identified angiographically. Methods: Records of 115 adult patients who underwent visceral angiography for endoscopically documented gastric (50 patients) or duodenal (65 patients) nonvariceal hemorrhage were retrospectively reviewed. Patients were subdivided into three groups according to whether angiographic evidence of arterial hemorrhage was present and whether embolization was performed (group 1 = no abnormality, no embolization; group 2 = no abnormality, embolization performed [empiric embolization]; and group 3 = abnormality present, embolization performed). Thirty-day rates and duration of primary hemostasis and survival were compared.ResultsFor patients with gastric sources of hemorrhage, the rate of primary hemostasis at 30 days after embolization was greater when embolization was performed in the setting of a documented angiographic abnormality than when empiric embolization was performed (67% vs. 42%). The rate of primary hemostasis at 30 days after angiography was greater for patients with duodenal bleeding who either underwent empiric embolization (60%) or embolization in the setting of angiographically documented arterial hemorrhage (58%) compared with patients who only underwent diagnostic angiogram (33%). Patients with duodenal hemorrhage who underwent embolization were less likely to require additional invasive procedures to control rebleeding (p = 0.006). Conclusion: Empiric arterial embolization may be advantageous in patients with a duodenal source of hemorrhage but not in patients with gastric hemorrhage.

  3. Warranting Failure: The "System" that Breeds Poverty and Starves Public Schools

    Science.gov (United States)

    Alexander, Kern; Salmon, Richard G.

    2007-01-01

    The inscription on the internal pedestal of the Statue of Liberty proclaiming "Give me your tired, your poor, your huddled masses" today is an ideal of another age. Compared with those of other developing countries, U.S. poverty rates are extraordinarily high, as are the odds of remaining in poverty intergenerationally. No longer do…

  4. Clozapine-Induced Myocarditis: Is Mandatory Monitoring Warranted for Its Early Recognition?

    Directory of Open Access Journals (Sweden)

    T. A. Munshi

    2014-01-01

    Full Text Available Clozapine is an atypical antipsychotic used for treatment resistant schizophrenia. Its potential to induce agranulocytosis is well known but it can also cause myocarditis. Clozapine is the only antipsychotic known to induce this side effect, typically early in the treatment, and literature is scarce on this condition. We are presenting a case report of a 21-year-old schizophrenic male who developed myocarditis within 3 weeks of starting on clozapine for his treatment resistant psychosis. We then aim to review some of the available literature and raise awareness among physicians as this condition can potentially be fatal if not detected early.

  5. Dewey's Epistemology: An Argument for Warranted Assertions, Knowing, and Meaningful Classroom Practice

    Science.gov (United States)

    Boyles, Deron R.

    2006-01-01

    In an effort to navigate the treacherous path between professionalism and social relevancy, this essay takes up an area of professional philosophy--epistemology--with the intention of reclaiming the integrative role John Dewey held for philosophy and classroom practice. Deron Boyles asserts that epistemology can and should represent an area of…

  6. 75 FR 77496 - Endangered and Threatened Species; Proposed Threatened and Not Warranted Status for Subspecies...

    Science.gov (United States)

    2010-12-10

    ... concern, related by the common driver of carbon dioxide (CO 2 ) emissions, is the modification of habitat... suggested that ecological influences or sexual selection, and not a geographical feature restricting gene.... The IPCC AR4 used a range of future greenhouse gas (GHG) emissions produced under six ``marker...

  7. A COGNITIVE-AXIOLOGICAL APPROACH TO PRINT ECO-ADVERTISEMENTS IN THE ECONOMIST: THE ENERGY SECTOR UNDER SCRUTINY

    Directory of Open Access Journals (Sweden)

    Ángel Felices Lago

    2009-10-01

    Full Text Available In this paper we intend to map out some of the dominant values in print advertisements announcing different types of environmentally friendly products and services from energy (oil, electricity, etc. and heavy industry corporations. We will analyse the qualities and values explicitly linked to ecological samples through metaphors, metonymies and image schemas and the way in which they are introduced in advertising
    discourse. To this end, we have selected a corpus of sample advertisements published in 12 editions of The Economist, a well-known, prestigious business magazine. The Lakoffian semantics analysis will be used in order to give us a more reliable estimate of values and metaphorical processes linked to environmental topics as well as an account of the cognitive and discursive means used to denote them.

  8. 26 CFR 1.414(r)-5 - Qualified separate line of business-administrative scrutiny requirement-safe harbors.

    Science.gov (United States)

    2010-04-01

    ... categories (among others): transportation equipment and services; banking, insurance, and finance; machinery... services in either the banking, insurance, or financial industry category, or the entertainment, sports, or... SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Pension, Profit...

  9. Scrutiny of the ASTRO consensus definition of biochemical failure in irradiated prostate cancer patients demonstrates its usefulness and robustness

    International Nuclear Information System (INIS)

    Hanlon, Alexandra L.; Hanks, Gerald E.

    2000-01-01

    Purpose: The goals of this study are: (1) to establish the robustness of the Fox Chase Cancer Center (FCCC) and the American Society for Therapeutic Radiology and Oncology (ASTRO) consensus definitions of failure by comparing biochemical estimates under various modifications of the censoring and failure time components to their respective unaltered definitions; (2) to isolate the source of variation between the two definitions of failure; and (3) to describe the hazard of failure over time for each definition. Methods: Between May 1989 and May 1997, 670 men were treated at Fox Chase Cancer Center for localized prostate cancer using three-dimensional conformal radiation therapy (3DCRT). These men were stratified into three groups for analysis: 111 men treated with adjuvant hormones; 204 men treated with radiation therapy alone and presenting with more favorable prognosis tumor characteristics; 255 men treated with radiation therapy alone and presenting with less favorable prognosis tumor characteristics. For each group, biochemical failure was estimated and compared using the FCCC and ASTRO definitions of failure. The robustness of each definition was evaluated by comparing estimates under the definition as stated to those under various modifications of the censoring and failure components. Analyses were also performed while excluding slow-progressing patients. To isolate the source of variation between the two failure definitions, estimates were compared for patients with agreement in failure status. Estimates of biochemical failure, and thus hazard rates, were made using Kaplan-Meier methodology. Results: ASTRO biochemical failure estimates were higher than the FCCC failure estimates in the first 5 years post-treatment. Beyond 5 years, ASTRO estimates level off, while the FCCC failure estimates continued to increase. These failure patterns were similar in all patient groups; however, patients treated with adjuvant hormones had a much higher risk of failure immediately following treatment under the ASTRO definition. Modifying the censoring pattern had little effect on failure estimates in any patient group, regardless of definition used. The exclusion of patients with slow prostate-specific antigen (PSA) doubling time did not result in biochemical estimates that differed significantly from those for all patients. The analysis of patients with agreement in failure status continued to demonstrate significant differences in estimates between the two definitions, and thus differences may be attributed to the specification of time to failure. For all patient groups, hazard rates were dependent upon failure definition: under the FCCC failure definition, patients were at constant risk of failure over the observation period; under the ASTRO failure definition, patients were at risk of failure during the first 4 years following treatment, and then at low risk of failure beyond 5 years. Conclusions: Both FCCC and ASTRO failure definitions were robust to modifications in censoring and the inclusion of patients with long doubling times. The ASTRO failure definition was robust to specifying the time to failure at first rise, as opposed to midway between nadir and first rise. Similarities in estimates for all patients versus patients with agreeing failure status suggest that differences in failure definition lie in the specification of time to failure. The ASTRO definition of failure is more appropriate because it does not impose an empirical failure marker but is based on the initiation of biochemical rise. The use of the ASTRO consensus definition demonstrated little risk of biochemical failure 4 years beyond treatment. The ASTRO failure definition should be adopted in all research involving biochemical failure analysis of men treated with radiation therapy

  10. The meaning of ice: scientific scrutiny and the visual record obtained from the British polar expeditions between 1772 and 1854

    OpenAIRE

    Ware, Trevor David Oliver

    2014-01-01

    This thesis is an analysis of the work produced by artists accompanying naval expeditions to the Arctic and Antarctic regions between 1772 and 1854. The expeditions were mainly by sea and supplemented in the Arctic by some overland. Their aims were scientific and organised chiefly, but not exclusively, in conjunction with the Royal Society of London. Various British Governments sought strategic advantages along with international recognition for finding both a Southern Continent and a North W...

  11. A scrutiny of matrix metalloproteinases in osteoclasts: evidence for heterogeneity and for the presence of MMPs synthesized by other cells

    DEFF Research Database (Denmark)

    Andersen, Thomas L; del Carmen Ovejero, Maria; Kirkegaard, Tove

    2004-01-01

    osteoclasts appears insensitive to MMP inhibitors. Our study shows that the confusion about osteoclastic MMPs in the literature reflects the remarkable ability of osteoclasts to adapt to their environment, as required by the structural or functional diversity of bone tissue. Our observations provide basic...... information needed for understanding the emerging role of MMPs in controlling cell signaling and bone resorption....

  12. Blog-Based Professional Development of English Teachers in Mumbai: The Potential of Innovative Practice under Scrutiny

    Science.gov (United States)

    Khan, Atiya

    2017-01-01

    The professional development of teachers in India is still, by and large, based on formal and outdated professional learning traditions, often characterised by crash courses and one-off workshops. In education, blogs have proven to be an effective means of establishing and maintaining collaborative learning networks and helping members reflect on…

  13. Under scrutiny. As public anxiety grows over health care horror stories, consumers are starting to fight back. Guess who's winning.

    Science.gov (United States)

    Bilchik, G S

    1996-05-05

    "We're getting dozens of calls every day from people who are frustrated and fed up," says one health care consumer rights advocate. The scenario is familiar: first come the horror stories, then trailblazing, media-engaging lawsuits, and finally the public learning curve starts to accelerate. Then the heat gets turned up on the government to act. That's where we're at right now. Where will we be tomorrow?

  14. Ciências da Educação em questão The Sciences of Education under scrutiny

    Directory of Open Access Journals (Sweden)

    Tarso Mazzotti

    2006-12-01

    Full Text Available As Ciências da Educação encontram-se em uma 'dispersão epistemológica' (Tardy, 1989, o que não é sua exclusividade, pois isso também ocorre com as Ciências do Homem, uma vez que ambas estão atadas ao programa de cientificidade que retira as pessoas do lugar de produção do conhecimento, tanto no paradigma moderno quanto no pós-moderno. Propõe-se, aqui, uma teoria humanista do conhecimento, na qual as três espécies de silogismo - entimema, dialético e demonstrativo - são consideradas complementares no processo de instituição dos conhecimentos, com base em critérios próprios das metodologias ou regras do fazer ou algoritmos reconhecidos pelos grupos sociais que as sustentam. Tais regras do fazer ou algoritmos não constituem uma lógica natural, uma vez que qualquer lógica é um cálculo. Os algoritmos para a produção de conhecimentos encontram-se na relação inseparável entre o orador (ethos, o auditório (pathos e o discurso (lógos, na qual são validados os argumentos. Donde, uma teoria humanista do conhecimento permite a sublimação da referida 'dispersão epistemológica', isso porque deixa explícita as situações nas quais um conhecimento é validado. Assim sendo, as metodologias são garantias razoáveis, não determinantes dos conhecimentos confiáveis, pois seus fiadores são os grupos sociais que os admitem e sustentam.The Sciences of Education experience an "epistemological dispersion" (Tardy, 1989, in which they are not alone, for the same happens to the Sciences of Man, both being attached to the program of scientificity that removes people from the place of production of knowledge, be it under the modern paradigm, be it under the postmodern. What is proposed here is a humanist theory of knowledge in which the three kinds of syllogism - enthymeme, dialectical, and demonstrative - are regarded as complementary in the process of establishing knowledge, based on criteria proper to the methodologies or rules of doing, or to algorithms recognized by the social groups that give support to them. Such rules of doing or algorithms do not constitute a natural logic, since any logic is a calculation. The algorithms for the production of knowledge are found in the indissoluble relation between the orator (ethos, the audience (pathos and the discourse (logos, where the arguments are validated. Hence, a humanist theory of knowledge allows the sublimation of the above-mentioned "epistemological dispersion", for it makes explicit the situations in which a piece of knowledge is validated. Thus, the methodologies are reasonable guarantees, but do not determine reliable knowledge, because its guarantors are the social groups that admit and support it.

  15. A Comparative In Vivo Scrutiny of Biosynthesized Copper and Zinc Oxide Nanoparticles by Intraperitoneal and Intravenous Administration Routes in Rats.

    Science.gov (United States)

    C, Ashajyothi; K Handral, Harish; Kelmani R, Chandrakanth

    2018-04-03

    During the present time, anti-microbial features of copper (Cu) and zinc oxide (ZnO) nanoparticles (NPs) are extensively used to combat the growth of pathogenic microbes. CuNPs and ZnONPs are recurrently used in cosmetics, medicine and food additives, and their potential for toxic impacts on human and ecosystem is of high concern. In this study, the fate and toxicity of 16- to 96-nm-ranged biosynthesized copper (Bio-CuNPs) and zinc oxide (Bio-ZnONPs) was assessed in male Wistar rats. In vivo exposures of the two nanoparticles are achieved through two different administration routes namely, intraperitoneal (i/p) and intravenous (i/v) injections. The three different concentrations, no observable adverse effect concentration (NOAEC), inhibitory concentration (IC 50 ) and total lethal concentration (TLC), were appraised at the dose range of 6.1 to 19.82 μg/kg and 11.14 to 30.3 μg/kg for Bio-CuNPs and Bio-ZnONPs respectively, for both i/p and i/v routes on 14th and 28th day of observation. These dose ranges are considered based on the previous study of antibacterial dose on multidrug-resistant pathogenic bacteria. In this study, we investigated the toxic effect of Bio-CuNPs and Bio-ZnONPs on animal behaviour, animal mass, haematologic indices, organ indices and histopathology of liver, spleen, kidney and brain organs. We found that i/v and i/p administration of Bio-ZnONPs in three different doses did not cause mortality and body weight was slightly reduced up to second week of administration compared with the vehicle control group. At the dose ranges of 11-16 μg/kg (i/v) and 24-30 μg/kg (i/p), no significant changes were observed in the serum creatinine level as well as serum ALT, serum AST level and ALP level which were 40.7 mg/dl, 37.9 IU/L and 82.4 IU/L normal as compared to vehicle control on 14th and 28th day of observation. These findings are confirmed in liver, kidney and spleen indices and histopathology studies. Furthermore, liver and kidney injury occurred when the concentrations of Bio-CuNPs were at 9.5 μg/kg (IC 50 ) and 11.7 μg/kg (TLC) for i/v route of administration. Similarly, increase in serum ALT (67.7 mg/dl), AST level (70 IU/L) and ALP (128 IU/L) was also observed. And the body weight was significantly lower than in the control group after 14th day, and there were statistically significant differences observed by this route; interestingly, the toxicity of Bio-CuNPs in serum is prolonged (up to 28th day). Effect of Bio-CuNPs through i/p route was considerably low as compare to the control. Results of the present study revealed that Bio-ZnONPs have no effect on kidney and liver function biomarkers (both i/v and i/p) as compared to Bio-CuNPs. Graphical abstract As shown in graphical abstract (Fig. 1), our aim is to assess the toxicity of Bio-CuNPs and Bio-ZnONPs through in vivo protocol. According to Kahru and Dubourguier reviews, AgNPs, CuNPs and ZnONPs have been historically used as biocides, for preventing the growth of microorganisms and algae (Kahru and Dubourguier 2010). Therefore, as like pesticides, nanomaterials should be monitored for their toxic response toward non-target species, including humans and animals. To gain a better understanding whether the accidental release of metal-containing NPs may pose a threat to non-target species, assessing of toxic effect is indispensable.The 'non-target organism' is an organism which will be exposed to NPs after their incidental release into the environment.

  16. How to Fairly Allocate Scarce Medical Resources: Ethical Argumentation under Scrutiny by Health Professionals and Lay People.

    Directory of Open Access Journals (Sweden)

    Pius Krütli

    Full Text Available Societies are facing medical resource scarcities, inter alia due to increased life expectancy and limited health budgets and also due to temporal or continuous physical shortages of resources like donor organs. This makes it challenging to meet the medical needs of all. Ethicists provide normative guidance for how to fairly allocate scarce medical resources, but legitimate decisions require additionally information regarding what the general public considers to be fair. The purpose of this study was to explore how lay people, general practitioners, medical students and other health professionals evaluate the fairness of ten allocation principles for scarce medical resources: 'sickest first', 'waiting list', 'prognosis', 'behaviour' (i.e., those who engage in risky behaviour should not be prioritized, 'instrumental value' (e.g., health care workers should be favoured during epidemics, 'combination of criteria' (i.e., a sequence of the 'youngest first', 'prognosis', and 'lottery' principles, 'reciprocity' (i.e., those who provided services to the society in the past should be rewarded, 'youngest first', 'lottery', and 'monetary contribution'.1,267 respondents to an online questionnaire were confronted with hypothetical situations of scarcity regarding (i donor organs, (ii hospital beds during an epidemic, and (iii joint replacements. Nine allocation principles were evaluated in terms of fairness for each type of scarcity along 7-point Likert scales. The relationship between demographic factors (gender, age, religiosity, political orientation, and health status and fairness evaluations was modelled with logistic regression.Medical background was a major predictor of fairness evaluations. While general practitioners showed different response patterns for all three allocation situations, the responses by lay people were very similar. Lay people rated 'sickest first' and 'waiting list' on top of all allocation principles-e.g., for donor organs 83.8% (95% CI: [81.2%-86.2%] rated 'sickest first' as fair ('fair' is represented by scale points 5-7, and 69.5% [66.2%-72.4%] rated 'waiting list' as fair. The corresponding results for general practitioners: 'prognosis' 79.7% [74.2%-84.9%], 'combination of criteria' 72.6% [66.4%-78.5%], and 'sickest first' 74.5% [68.6%-80.1%; these were the highest-rated allocation principles for donor organs allocation. Interestingly, only 44.3% [37.7%-50.9%] of the general practitioners rated 'instrumental value' as fair for the allocation of hospital beds during a flu epidemic. The fairness evaluations by general practitioners obtained for joint replacements: 'sickest first' 84.0% [78.8%-88.6%], 'combination of criteria' 65.6% [59.2%-71.8%], and 'prognosis' 63.7% [57.1%-70.0%]. 'Lottery', 'reciprocity', 'instrumental value', and 'monetary contribution' were considered very unfair allocation principles by both groups. Medical students' ratings were similar to those of general practitioners, and the ratings by other health professionals resembled those of lay people.Results are partly at odds with current conclusions proposed by some ethicists. A number of ethicists reject 'sickest first' and 'waiting list' as morally unjustifiable allocation principles, whereas those allocation principles received the highest fairness endorsements by lay people and to some extent also by health professionals. Decision makers are advised to consider whether or not to give ethicists, health professionals, and the general public an equal voice when attempting to arrive at maximally endorsed allocations of scarce medical resources.

  17. Under consumers' scrutiny - an investigation into consumers' attitudes and concerns about nudging in the realm of health behavior.

    Science.gov (United States)

    Junghans, Astrid F; Cheung, Tracy T L; De Ridder, Denise D T

    2015-04-09

    Nudging strategies have recently attracted attention from scholars and policy makers for their potential in influencing people's behaviors on large scales. But is the fact that nudges do not forbid any choice-options or significantly alter people's economic incentives sufficient to conclude that nudges should be implemented? While this is discussed amongst scholars from various disciplines the voices of consumers, the target-group of nudges, remain unheard. Since understanding their knowledge about nudging and their opinions on being nudged are crucial for the evaluation of the moral appropriateness of nudging, the current study examines consumers' knowledge of and attitudes toward nudging in general and the realm of health behavior. In this qualitative investigation in-depth semi-structured interviews with UK consumers were conducted to examine consumers' attitudes to four domains of inquiry around which the scholarly discussions about nudging have revolved: consumers' approval of nudging, consumers' views on the origin of nudges, consumers' perceived effectiveness of nudging, and consumers' concerns about manipulative aspects of nudging. Interviews revealed that consumers are largely unfamiliar with the concept of nudging altogether. Once defined and explained to them most consumers approve of the concept, especially in the realm of health behavior, given particular conditions: 1. Nudges should be designed for benefiting individuals and society; 2. consumers comprehend the decision-making context and the reasoning behind the promotion of the targeted behavior. Interviews revealed very limited concerns with manipulative aspects of nudges. These findings call for better information-management to ensure consumers knowledge of nudges and awareness of their current implementation. Under that condition the findings encourage the implementation of nudges benefitting individuals and society in domains that consumers comprehend, such as health behaviors. Further research is required to clarify consumers' concerns and requirements for nudges in more complex domains such as financial decisions and retirement plans.

  18. Under consumers' scrutiny - an investigation into consumers' attitudes and concerns about nudging in the realm of health behavior

    NARCIS (Netherlands)

    Junghans, Astrid F; Cheung, Tracy T L; De Ridder, Denise D T

    2015-01-01

    BACKGROUND: Nudging strategies have recently attracted attention from scholars and policy makers for their potential in influencing people's behaviors on large scales. But is the fact that nudges do not forbid any choice-options or significantly alter people's economic incentives sufficient to

  19. How to Fairly Allocate Scarce Medical Resources: Ethical Argumentation under Scrutiny by Health Professionals and Lay People.

    Science.gov (United States)

    Krütli, Pius; Rosemann, Thomas; Törnblom, Kjell Y; Smieszek, Timo

    2016-01-01

    Societies are facing medical resource scarcities, inter alia due to increased life expectancy and limited health budgets and also due to temporal or continuous physical shortages of resources like donor organs. This makes it challenging to meet the medical needs of all. Ethicists provide normative guidance for how to fairly allocate scarce medical resources, but legitimate decisions require additionally information regarding what the general public considers to be fair. The purpose of this study was to explore how lay people, general practitioners, medical students and other health professionals evaluate the fairness of ten allocation principles for scarce medical resources: 'sickest first', 'waiting list', 'prognosis', 'behaviour' (i.e., those who engage in risky behaviour should not be prioritized), 'instrumental value' (e.g., health care workers should be favoured during epidemics), 'combination of criteria' (i.e., a sequence of the 'youngest first', 'prognosis', and 'lottery' principles), 'reciprocity' (i.e., those who provided services to the society in the past should be rewarded), 'youngest first', 'lottery', and 'monetary contribution'. 1,267 respondents to an online questionnaire were confronted with hypothetical situations of scarcity regarding (i) donor organs, (ii) hospital beds during an epidemic, and (iii) joint replacements. Nine allocation principles were evaluated in terms of fairness for each type of scarcity along 7-point Likert scales. The relationship between demographic factors (gender, age, religiosity, political orientation, and health status) and fairness evaluations was modelled with logistic regression. Medical background was a major predictor of fairness evaluations. While general practitioners showed different response patterns for all three allocation situations, the responses by lay people were very similar. Lay people rated 'sickest first' and 'waiting list' on top of all allocation principles-e.g., for donor organs 83.8% (95% CI: [81.2%-86.2%]) rated 'sickest first' as fair ('fair' is represented by scale points 5-7), and 69.5% [66.2%-72.4%] rated 'waiting list' as fair. The corresponding results for general practitioners: 'prognosis' 79.7% [74.2%-84.9%], 'combination of criteria' 72.6% [66.4%-78.5%], and 'sickest first' 74.5% [68.6%-80.1%); these were the highest-rated allocation principles for donor organs allocation. Interestingly, only 44.3% [37.7%-50.9%] of the general practitioners rated 'instrumental value' as fair for the allocation of hospital beds during a flu epidemic. The fairness evaluations by general practitioners obtained for joint replacements: 'sickest first' 84.0% [78.8%-88.6%], 'combination of criteria' 65.6% [59.2%-71.8%], and 'prognosis' 63.7% [57.1%-70.0%]. 'Lottery', 'reciprocity', 'instrumental value', and 'monetary contribution' were considered very unfair allocation principles by both groups. Medical students' ratings were similar to those of general practitioners, and the ratings by other health professionals resembled those of lay people. Results are partly at odds with current conclusions proposed by some ethicists. A number of ethicists reject 'sickest first' and 'waiting list' as morally unjustifiable allocation principles, whereas those allocation principles received the highest fairness endorsements by lay people and to some extent also by health professionals. Decision makers are advised to consider whether or not to give ethicists, health professionals, and the general public an equal voice when attempting to arrive at maximally endorsed allocations of scarce medical resources.

  20. Polymorphisms in the vitamin D receptor and their associations with risk of schizophrenia and selected anthropometric measures.

    Science.gov (United States)

    Handoko, H Y; Nancarrow, D J; Mowry, B J; McGrath, J J

    2006-01-01

    The association between vitamin D levels and skeletal growth has long been recognized. However, exposure to low levels of vitamin D during early life is also known to alter brain development, and is a candidate risk factor for schizophrenia. This study examines the association between four polymorphisms in the vitamin D receptor (VDR) and 1) risk of schizophrenia, and 2) three anthropometric variables (height, head size, and head shape). Four single-nucleotide polymorphisms (SNPs; rs10735810/FokI, rs1544410/BsmI, rs7975232/ApaI, and rs731236/TaqI) in the VDR gene were genotyped in 179 individuals with schizophrenia and 189 healthy controls. No significant associations were detected between any of the four VDR SNPs and risk of schizophrenia. Patients were slightly but significantly shorter compared to controls. Of the four SNPs, only rs10735810/FokI was associated with any of the anthropometric measures: the M4 isoform of this SNP was significantly associated with larger head size (P = 0.002). In light of the evidence demonstrating a role for vitamin D during brain development, the association between polymorphisms in VDR and brain development warrants closer scrutiny.

  1. Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood.

    Directory of Open Access Journals (Sweden)

    Sukanta Saha

    2009-03-01

    Full Text Available BACKGROUND: Advanced paternal age (APA is associated with an increased risk of neurodevelopmental disorders such as autism and schizophrenia, as well as with dyslexia and reduced intelligence. The aim of this study was to examine the relationship between paternal age and performance on neurocognitive measures during infancy and childhood. METHODS AND FINDINGS: A sample of singleton children (n = 33,437 was drawn from the US Collaborative Perinatal Project. The outcome measures were assessed at 8 mo, 4 y, and 7 y (Bayley scales, Stanford Binet Intelligence Scale, Graham-Ernhart Block Sort Test, Wechsler Intelligence Scale for Children, Wide Range Achievement Test. The main analyses examined the relationship between neurocognitive measures and paternal or maternal age when adjusted for potential confounding factors. Advanced paternal age showed significant associations with poorer scores on all of the neurocognitive measures apart from the Bayley Motor score. The findings were broadly consistent in direction and effect size at all three ages. In contrast, advanced maternal age was generally associated with better scores on these same measures. CONCLUSIONS: The offspring of older fathers show subtle impairments on tests of neurocognitive ability during infancy and childhood. In light of secular trends related to delayed fatherhood, the clinical implications and the mechanisms underlying these findings warrant closer scrutiny.

  2. Mitigation and Compensation under EU Nature Conservation Law in the Flemish Region: Beyond the Deadlock for Development Projects?

    Directory of Open Access Journals (Sweden)

    Hendrik Schoukens

    2014-05-01

    Full Text Available For years, the predicament of many of the European protected habitats and species in the Flemish Region, as in many other Member States, passed relatively unnoticed. The lack of proper rules and clear implementation rules fuelled the impression amongst project developers and planning authorities that the impacts of project developments on biodiversity did not really warrant closer assessment. However, in the past ten years, strict national case law has significantly altered this view. Faced with tighter judicial scrutiny, the Habitats and Birds Directives were seen as an important obstacle to project development. Hence mitigation and compensation have now come up as novel approaches to better align spatial aspirations with the conservation of nature. In reality, mitigation was often used as a cover-up for projects that would not fit the strict requirements enshrined in the derogatory clauses. Interestingly, the Belgian Council of State showed itself quite cautious in reasserting the lax view of some planning authorities on mitigation and compensation. In reviewing the legality of several new approaches to mitigation and compensation, the Belgian Council of State, which was initially very cautious in quashing decisions that would actually jeopardise major infrastructure developments, has rendered some compelling rulings on the specific application of mitigation and compensatory measures in a spatial planning context. By letting the objectives of EU nature conservation law prevail in the face of economic interests, the recent case law of the Belgian Council of State can be seen as a remarkable example of judicial environmental activism.

  3. Complementing the surveillance law principles of the Court of Strasbourg with its environmental law principles. An integrated technology approach to a human rights framework for surveillance

    NARCIS (Netherlands)

    de Hert, P.J.A.; Galetta, Antonella

    2014-01-01

    If one looks at the case law of the European Court of Human Rights on surveillance matters, a well mature set of principles emerge, namely: legality, legitimacy, proportionality (the standard check) and, if the Court is "on it", also necessity and subsidiarity (the closer scrutiny check). We pass

  4. International Law as an Argumentative Practice: On Wohlrapp’s Concept of Argument

    NARCIS (Netherlands)

    Venzke, I.

    2016-01-01

    It has become a commonplace to view international law as an argumentative practice. This commonplace, it is argued, clouds strong differences that re-emerge with closer scrutiny. What, specifically, is the place of reason, rhetoric or violence in the practice of arguing? The present article explores

  5. Autonomy and Accountability in Schools Serving Disadvantaged Communities

    Science.gov (United States)

    Klein, Esther Dominique

    2017-01-01

    Purpose: Increased school autonomy and accountability have been a common denominator of national reforms in otherwise heterogeneous governance systems in Europe and the USA. The paper argues that because schools serving disadvantaged communities (SSDCs) often have lower average performance, they are more often sanctioned or under closer scrutiny,…

  6. How Do Pre-Service Teachers' Reflective Processes Differ in Relation to Different Contexts?

    Science.gov (United States)

    Kaasila, Raimo; Lauriala, Anneli

    2012-01-01

    Reflective practice represents a central theme in teacher education. The focus of this study is to look at pre-service teachers' reflection processes and their breadth and depth in four different contexts. Our research data consist of 53 pre-service teachers' mathematics portfolios, from which three were selected for closer scrutiny. The chosen…

  7. Integrated development planning in South Africa: lessons for international peacebuiling?

    CSIR Research Space (South Africa)

    Gueli, R

    2007-01-01

    Full Text Available to overcome Apartheid’s violent history, deserves closer scrutiny by international peacebuilding experts. This is because South Africa’s approach to development – although not perfect – is centred on integrated governance and has, to some extent, played...

  8. Judicial "translation" and contextualisation of values: rethinking the ...

    African Journals Online (AJOL)

    The relevance of Mayelane v Ngwenyama (2013 4 SA 415 (CC)) has not been exhausted. Particularly the constitutional mandate undertaken by the Constitutional Court to "develop" customary law deserves closer scrutiny. In Mayelane the Constitutional Court, in seeking to vindicate the dignity and equality of women in ...

  9. The construction of 'social constructionism': A case study in the rhetoric of debate

    NARCIS (Netherlands)

    Katzko, M.W.

    2002-01-01

    There is a dimension to the ongoing debate on `constructionism' that deserves closer scrutiny. In this paper I wish to draw attention to some features of the debate as movements in opposition, illustrated with examples comparing the articles in Theory & Psychology, 11(3), with literature outside

  10. Aligning Olympic Education with the Liberal Arts: A Curriculum Blueprint from Taiwan

    Science.gov (United States)

    Hsu, Li-Hong Leo; Kohe, Geoffery Zain

    2015-01-01

    Background: For some time the Olympics have enjoyed a relatively cosy, and quite unsurprising, relationship with Physical Education and its practitioners. Yet, as academics continue their critiques of all matters Olympic, this seemingly symbiotic partnership is being placed under much closer scrutiny. The debates are typically orientated around…

  11. Scientia Militaria: South African Journal of Military Studies

    African Journals Online (AJOL)

    In this regard, the constituent elements of good order at sea house a more critical line to view security off Africa through safe access to resources (food and minerals), safe sea routes, as well as dominium and jurisdiction. Opposition to threats off the African coast tends to privilege naval responses, but closer scrutiny reflects ...

  12. Audiovisual aid viewing immediately before pediatric induction moderates the accompanying parents' anxiety

    NARCIS (Netherlands)

    Berghmans, Johan; Weber, Frank; van Akoleyen, Candyce; Utens, Elisabeth; Adriaenssens, Peter; Klein, Jan; Himpe, Dirk

    2012-01-01

    Parents accompanying their child during induction of anesthesia experience stress. The impact of audiovisual aid (AVA) on parental state anxiety and assessment of the child's anxiety at induction have been studied previously but need closer scrutiny. One hundred and twenty parents whose children

  13. BIOSENSOR TECHNOLOGY EVALUATIONS FOR REAL-TIME/SOURCE WATER PROTECTION

    Science.gov (United States)

    Recent advances in electronics and computer technology have made great strides in the field of remote sensing and biomonitoring. The quality of drinking water sources has come under closer scrutiny in recent years. Issues ranging from ecological to public health and national se...

  14. Timber net value and physical output changes following wildfire in the northern Rocky Mountains: estimates for specific fire situations

    Science.gov (United States)

    Patrick J. Flowers; Patricia B. Shinkle; Daria A. Cain; Thomas J. Mills

    1985-01-01

    In the last decade, the fire management program of the Forest Service, U.S. Department of Agriculture, has come under closer scrutiny because of ever-rising program costs. The Forest Service has responded by conducting several studies analyzing the economic efficiency of its fire management program. Some components of the analytical models have been difficult to...

  15. TRADITIONAL REMEDIES IN CHILDREN AROUND EASTERN ...

    African Journals Online (AJOL)

    hi-tech

    2003-08-08

    Aug 8, 2003 ... remain largely unproven by the scientific method and the concern about adverse effects have led to closer scrutiny of these products (4). Whereas most traditional remedies are safe, the potential for adverse effects or intoxication exists, as does the possibility of interaction with conventional drugs (2, 5-8).

  16. Corporate Social Responsibility: Practices of Ethics in Higher Education Institutions

    Science.gov (United States)

    Law, Marla S.

    2016-01-01

    The purpose of this study was to explore and examine perceptions among public and private higher education leaders in Pennsylvania regarding their institutions Corporate Social Responsibility (CSR) codes of conduct, ethics training programs, and practices of ethics. Highly publicized misconduct incidents warranted the need for scrutiny of the…

  17. Politics and Policies of Promoting Multilingualism in the European Union

    Science.gov (United States)

    Romaine, Suzanne

    2013-01-01

    This article examines the politics of policies promoting multilingualism in the European Union (EU), specifically in light of the recently released European Union Civil Society Platform on Multilingualism. As the most far-reaching and ambitious policy document issued by the European Commission, the Platform warrants close scrutiny at a significant…

  18. 78 FR 65541 - Federal Agricultural Mortgage Corporation Funding and Fiscal Affairs; Farmer Mac Liquidity...

    Science.gov (United States)

    2013-11-01

    ... attention issues and concerns that they believe warrant further or heightened FCA scrutiny. The second...; Divide the 90-day liquidity reserve into three tiers so Farmer Mac has a sufficient amount of cash and... that can be traded at fair value and an explicit public backstop.'' From the FCA's perspective, whether...

  19. Accounting for Systems Analysts in the 21st Century

    Science.gov (United States)

    Giordano, Thomas; McAleer, Brenda; Szakas, Joseph S.

    2010-01-01

    Computer Information System (CIS) majors are required to successfully complete an introductory accounting course. Given the current forces in the financial world, the appropriateness of this course warrants scrutiny as to whether it properly serves the student, and the degree to which it continues to meet the IS 2002 outcomes. The current business…

  20. Cancer patients treated with sunitinib or sorafenib have sufficient antibody and cellular immune responses to warrant influenza vaccination.

    Science.gov (United States)

    Mulder, Sasja F; Jacobs, Joannes F M; Olde Nordkamp, Michel A M; Galama, Joep M D; Desar, Ingrid M E; Torensma, Ruurd; Teerenstra, Steven; Mulders, Peter F A; Vissers, Kris C P; Punt, Cornelis J A; de Vries, I Jolanda M; van Herpen, Carla M L

    2011-07-01

    The tyrosine kinase inhibitors sorafenib and sunitinib have efficacy in several types of cancer. Recent studies indicate that these agents affect the immune system. The way it affects the immune response to influenza vaccination is unknown. The aim of this study was to elucidate the specific immune response to seasonal flu vaccination in cancer patients treated with sunitinib or sorafenib. Sunitinib- or sorafenib-treated cancer patients were vaccinated against seasonal influenza with an inactivated vaccine. Healthy controls and patients with metastatic renal cell cancer (mRCC) without systemic treatment (nontreated mRCC controls) were included for comparison. Antibody responses were measured at baseline, day 8, and day 22 by a standard hemagglutination inhibition assay and cellular T-cell responses at baseline and day 8 by proliferation assay and secretion of cytokines. Forty subjects were enrolled: 16 patients treated with sunitinib, 6 patients with sorafenib, 7 nontreated mRCC controls, and 11 healthy controls. All patients treated with sunitinib and sorafenib developed seroprotection rates comparable with controls. Functional T-cell reactivity was observed in all groups, except for patients treated with sorafenib who showed a decreased proliferation rate and IFN-γ/IL-2 production and increased IL-10 compared with healthy controls. We conclude that influenza vaccination should be recommended to cancer patients treated with sunitinib or sorafenib.

  1. Cancer patients treated with sunitinib or sorafenib have sufficient antibody and cellular immune responses to warrant influenza vaccination

    NARCIS (Netherlands)

    Mulder, Sasja F.; Jacobs, Joannes F. M.; Olde Nordkamp, Michel A. M.; Galama, Joep M. D.; Desar, Ingrid M. E.; Torensma, Ruurd; Teerenstra, Steven; Mulders, Peter F. A.; Vissers, Kris C. P.; Punt, Cornelis J. A.; de Vries, I. Jolanda M.; van Herpen, Carla M. L.

    2011-01-01

    The tyrosine kinase inhibitors sorafenib and sunitinib have efficacy in several types of cancer. Recent studies indicate that these agents affect the immune system. The way it affects the immune response to influenza vaccination is unknown. The aim of this study was to elucidate the specific immune

  2. Cancer patients treated with sunitinib or sorafenib have sufficient antibody and cellular immune responses to warrant influenza vaccination

    NARCIS (Netherlands)

    Mulder, S.F.; Jacobs, J.F.M.; Olde Nordkamp, M.A.M.; Galama, J.M.D.; Desar, I.M.E.; Torensma, R.; Teerenstra, S.; Mulders, P.F.; Vissers, K.C.P.; Punt, C.J.A.; Vries, I.J.M. de; Herpen, C.M.L. van

    2011-01-01

    PURPOSE: The tyrosine kinase inhibitors sorafenib and sunitinib have efficacy in several types of cancer. Recent studies indicate that these agents affect the immune system. The way it affects the immune response to influenza vaccination is unknown. The aim of this study was to elucidate the

  3. Contrast blush in pediatric blunt splenic trauma does not warrant the routine use of angiography and embolization.

    Science.gov (United States)

    Bansal, Samiksha; Karrer, Frederick M; Hansen, Kristine; Partrick, David A

    2015-08-01

    Splenic artery embolization (SAE) in the presence of contrast blush (CB) has been recommended to reduce the failure rate of nonoperative management. We hypothesized that the presence of CB on computed tomography has minimal impact on patient outcomes. A retrospective review was conducted of all children (splenic trauma over a 10-year period at a level 1 pediatric trauma center. Data are presented as mean ± standard error of mean. Seven hundred forty children sustained blunt abdominal trauma, of which 549 had an identified solid organ injury. Blunt splenic injury was diagnosed in 270 of the 740 patients. All patients were managed nonoperatively without SAE. CB was seen on computed tomography in 47 patients (17.4%). There were no significant differences in the need for blood transfusion (12.5% vs 11.1%) or length of stay (3.1 vs 3.3 days) or need for splenectomy when compared in children with or without CB. Pediatric trauma patients with blunt splenic injuries can be safely managed without SAE and physiologic response and hemodynamic stability should be the primary determinants of appropriate management. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. What level of concern is warranted with respect to release of production waters on the Grand Banks of Newfoundland?

    International Nuclear Information System (INIS)

    Andrews, C.; Payne, J.; Guiney, J.; Lee, K.

    2009-01-01

    The Terra Nova, Hibernia, White Rose and Hebron offshore fields are situated in an important fishing area at the edge of the Grand Banks of Newfoundland. The offshore oil and gas industry must consider its potential effects on fisheries and the environment. This presentation discussed the potential scale and nature of any impacts at individual development sites. Most information from field and laboratory studies suggests that offshore impacts will likely be minimal with little potential for any impacts beyond individual rig sites. Fishery closure zones around rigs could occasionally act as nursery areas or marine protected areas. The authors noted that such general statements should be approached with caution given that some uncertainties remain about the effects of oil development, including the potential for chronic effects of produced water on fish and other biota. The presentation reviewed recent laboratory and field studies carried out under the Program of Energy Research and Development (PERD) to 2008. Industry Environmental Effects Management (EEM) programs in the Grand Banks are presently geared towards providing early warning of any impacts on fish health, fish quality, sediment toxicity, and primary productivity. EEM programs also help reveal new insights which are not possible through laboratory studies.

  5. Does the evidence about health risks associated with nitrate ingestion warrant an increase of the nitrate standard for drinking water?

    Science.gov (United States)

    van Grinsven, Hans JM; Ward, Mary H; Benjamin, Nigel; de Kok, Theo M

    2006-01-01

    Several authors have suggested that it is safe to raise the health standard for nitrate in drinking water, and save money on measures associated with nitrate pollution of drinking water resources. The major argument has been that the epidemiologic evidence for acute and chronic health effects related to drinking water nitrate at concentrations near the health standard is inconclusive. With respect to the chronic effects, the argument was motivated by the absence of evidence for adverse health effects related to ingestion of nitrate from dietary sources. An interdisciplinary discussion of these arguments led to three important observations. First, there have been only a few well-designed epidemiologic studies that evaluated ingestion of nitrate in drinking water and risk of specific cancers or adverse reproductive outcomes among potentially susceptible subgroups likely to have elevated endogenous nitrosation. Positive associations have been observed for some but not all health outcomes evaluated. Second, the epidemiologic studies of cancer do not support an association between ingestion of dietary nitrate (vegetables) and an increased risk of cancer, because intake of dietary nitrate is associated with intake of antioxidants and other beneficial phytochemicals. Third, 2–3 % of the population in Western Europe and the US could be exposed to nitrate levels in drinking water exceeding the WHO standard of 50 mg/l nitrate, particularly those living in rural areas. The health losses due to this exposure cannot be estimated. Therefore, we conclude that it is not possible to weigh the costs and benefits from changing the nitrate standard for drinking water and groundwater resources by considering the potential consequences for human health and by considering the potential savings due to reduced costs for nitrate removal and prevention of nitrate pollution. PMID:16989661

  6. Does the evidence about health risks associated with nitrate ingestion warrant an increase of the nitrate standard for drinking water?

    Science.gov (United States)

    van Grinsven, Hans J M; Ward, Mary H; Benjamin, Nigel; de Kok, Theo M

    2006-09-21

    Several authors have suggested that it is safe to raise the health standard for nitrate in drinking water, and save money on measures associated with nitrate pollution of drinking water resources. The major argument has been that the epidemiologic evidence for acute and chronic health effects related to drinking water nitrate at concentrations near the health standard is inconclusive. With respect to the chronic effects, the argument was motivated by the absence of evidence for adverse health effects related to ingestion of nitrate from dietary sources. An interdisciplinary discussion of these arguments led to three important observations. First, there have been only a few well-designed epidemiologic studies that evaluated ingestion of nitrate in drinking water and risk of specific cancers or adverse reproductive outcomes among potentially susceptible subgroups likely to have elevated endogenous nitrosation. Positive associations have been observed for some but not all health outcomes evaluated. Second, the epidemiologic studies of cancer do not support an association between ingestion of dietary nitrate (vegetables) and an increased risk of cancer, because intake of dietary nitrate is associated with intake of antioxidants and other beneficial phytochemicals. Third, 2-3 % of the population in Western Europe and the US could be exposed to nitrate levels in drinking water exceeding the WHO standard of 50 mg/l nitrate, particularly those living in rural areas. The health losses due to this exposure cannot be estimated. Therefore, we conclude that it is not possible to weigh the costs and benefits from changing the nitrate standard for drinking water and groundwater resources by considering the potential consequences for human health and by considering the potential savings due to reduced costs for nitrate removal and prevention of nitrate pollution.

  7. When pathological and radiological correlation is achieved, excision of fibroadenoma with lobular neoplasia on core biopsy is not warranted.

    Science.gov (United States)

    Fives, C; O'Neill, C J; Murphy, R; Corrigan, M A; O'Sullivan, M J; Feeley, L; Bennett, M W; O'Connell, F; Browne, T J

    2016-12-01

    The diagnosis and management of lobular neoplasia (LN) including lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia (ALH) remains controversial. Current management options after a core needle biopsy (CNB) with lobular neoplasia (LN) incorporating both ALH and LCIS include excision biopsy or careful clinical and radiologic follow up. A retrospective analysis of the surgical database at Cork University Hospital was performed to identify all core needle biopsies from January 1st 2010 to 31st December 2013 with a diagnosis of FA who subsequently underwent surgical excision biopsy. All cases with associated LN including ALH and classical LCIS were selected. We excluded cases with coexistent ductal carcinoma in situ (DCIS), invasive carcinoma, LN associated with necrosis, pleomorphic lobular carcinoma in situ (PLCIS) or lesions which would require excision in their own right (papilloma, radial scar, atypical ductal hyperplasia (ADH) or flat epithelial atypia (FEA)). Cases in which the radiologic targeted mass was discordant with a diagnosis of FA were also excluded. 2878 consecutive CNB with a diagnosis of FA were identified. 25 cases had a diagnosis of concomitant ALH or classical LCIS. Our study cohort consisted of 21 women with a mean age 53 years (age range 41-70 years). The core biopsy diagnosis was of LCIS and FA in 16 cases and ALH and FA in 5 cases. On excision biopsy, a FA was confirmed in all 21 cases. In addition to the FA, residual LCIS was present in 14 cases with residual ALH in 2 cases. One of the twenty-one cases (4.8%) was upgraded to invasive ductal carcinoma on excision. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Your Photos Or Mine: An Examination of the Laws Governing Warranted Searches and Subpoenas for the Photojournalist's Work Product.

    Science.gov (United States)

    Sherer, Michael D.

    Noting that there are no easy answers when a photojournalist is subjected to a legal request for his or her work products from governmental officials, this paper examines how state and federal laws and court decisions have both enhanced and inhibited a photojournalist's right to protect negatives, photographs, films, and videotapes from government…

  9. Do all patients with idiopathic pulmonary fibrosis warrant a trial of therapeutic intervention? A pro-con perspective.

    Science.gov (United States)

    Moodley, Yuben; Corte, Tamera; Richeldi, Luca; King, Talmadge E

    2015-04-01

    Idiopathic pulmonary fibrosis (IPF) is an incurable condition that is characterized by progressive pulmonary fibrosis, architectural distortion of the lung and loss of gas exchange units. Until recently, there was no effective treatment for this condition. However, there were two landmark trials published earlier this year, which have changed the management of this condition. Pirfenidone (Assessment of Pirfenidone to Confirm Efficacy and Safety in Idiopathic Pulmonary Fibrosis trial) and nintedanib (Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis-1 and -2 trials) have both demonstrated positive outcomes in patients with IPF. In this perspective, we critically discuss the role of these agents in IPF and in the broader pulmonary fibrosis population. © 2015 Asian Pacific Society of Respirology.

  10. How much complexity is warranted in a rainfall-runoff model? Findings obtained from symbolic regression, using Eureqa

    Science.gov (United States)

    Abrahart, R. J.; Beriro, D. J.

    2012-04-01

    The information content in a rainfall-runoff record is sufficient to support models of only very limited complexity (Jakeman and Hornberger, 1993). This begs the question of what limits should observed data place on the allowable complexity of rainfall-runoff models? Eureqa1 (Schmidt and Lipson, 2009) - pronounced "eureka" - is a software tool for finding equations and detecting mathematical relationships in a dataset. The challenge, for both software and modeller, is to identify, by means of symbolic regression, the simplest mathematical formulas which describe the underlying mechanisms that produced the data. It actually delivers, however, a series of preferred modelling solutions comprising one champion for each specific level of complexity i.e. related to solution enlargement involving the progressive incorporation of additional permitted factors (internal operators/ external drivers). The potential benefit of increased complexity can as a result be assessed in a rational manner. Eureqa is free to download and use; and, in the current study, has been employed to construct a set of rainfall-runoff transfer function models for the Annapolis River at Wilmot, in north-western Nova Scotia, Canada. The climatic conditions in this catchment present an interesting set of modelling challenges; daily variations and seasonal changes in temperature, snowfall and retention result in great difficulty for runoff prediction by means of a data-driven approach. Data from 10 years of daily observations are used in the present study (01/01/2000-31/12/2009): comprising [i] discharge, [ii] total rainfall (excluding snowfall), [iii] total snowfall, [iv] thickness of snow cover, and [v] maximum and [vi] minimum temperature. Precipitation occurs throughout the whole year being slightly lower during summer. Snowfall is common from November until April and rare hurricane weather may occur in autumn. The average maximum temperature is below 0 0C in January and February, but significant variation may result, producing milder weather and snowmelt throughout the winter. The average minimum temperature is below 0 0C during half of the year, such that freezing and melting occur frequently. The principal rainfall-runoff drivers are found to be lagged discharge and lagged precipitation, as expected. The complexity-accuracy trade-off, is nevertheless found to exhibit threshold behaviour, in which snow cover is eventually included at higher levels of complexity to account for multifaceted cold season processes.

  11. Chronic rectal bleeding after high dose conformal treatment of prostate cancer warrants modification of existing morbidity scales

    International Nuclear Information System (INIS)

    Hanlon, A.L.; Schulthiess, T.E.; Hunt, M.A.; Movsas, B.; Peter, R.; Hanks, G.E.

    1996-01-01

    Purpose: Serious late morbidity (Grade (3(4))) from the conformal treatment of prostate cancer has been reported in <1% to 6% of patients. This study demonstrates that the reported frequency of Grade (3(4)) complications varies by the morbidity scale selected and that no existing morbidity scale adequately represents chronic rectal bleeding, which is our most frequent persisting late sequela of high dose conformal treatment. Materials and Methods: Between (5(89)) and (12(93)), 352 patients with T1-3 NXM0 prostate cancers were treated with our 4-field conformal technique without special rectal blocking. This technique includes a 1 cm margin from the CTV to the PTV in all directions. The median follow-up for these patients was 38 mos (4 to 78), and the median ICRU reporting point dose was 74 Gy (63 to 81). Patients are followed at six month intervals, and no patient is lost to follow-up. Three morbidity scales are assessed, the RTOG, the late effects group (LENT), and our modification of the LENT (FC-LENT). This modification registers chronic rectal bleeding requiring more than two coagulations as a grade 3 event. Estimates for Grade (3(4)) late GI complication rates were determined using Kaplan-Meier methodology. Differences in morbidity rates were evaluated using the log-rank test and differences in time to latency of complications were evaluated using the nonparametric Wilcoxon test. The duration of severe symptoms with chronic rectal bleeding is measured from the first to the last transrectal coagulation. Results: Sixteen patients developed Grade (3(4)) complications by one of the three morbidity scales. Two patients required surgery (colostomy, sigmoid resection), 5 required a transfusion, and 9 required more than two coagulations. The median latency to the third coagulation (plus or minus transfusions) was 24 mos (17 to 40). The median duration of bleeding between the first and last coagulation was 6 mos (3 to 25), illustrating the chronicity of this problem. The median latency for the other Grade (3(4)) complications (surgery or transfusion alone) was 10 mos (9 to 32). This latency is significantly shorter than for three or more coagulations (p=.01). The five year actuarial rate of Grade (3(4)) complications by each scale are: RTOG .7%, LENT 2%, FC-LENT 6% (p=.002). The rate of chronic rectal bleeding increases with increasing dose and is low in patients treated with conventional technique due to lower doses. Conclusions: (1) Chronic rectal bleeding is our most frequent complication of conformal treatment of prostate cancer requiring multiple coagulations or transfusions. This complication appears later in follow-up (24 mos versus 10 mos) and is present for a long duration (6 mos). We believe this justifies the inclusion of chronic rectal bleeding requiring multiple procedures as a Grade 3 event. Special rectal blocking that reduces the rectal margin around the prostate for some or all of the treatment reduces the frequency of chronic rectal bleeding, although one must be very cautious to not shield cancers occupying the posterior lobe; of the prostate. (2) Our data illustrates that published morbidity rates are highly dependent on the morbidity scale selected, as our data show .7% RTOG, 2% LENT and 6% with the FC-LENT. Obviously, a uniform scale is required that includes the serious late effects associated with the conformal treatment of prostate cancer

  12. Chronic rectal bleeding after high-dose conformal treatment of prostate cancer warrants modification of existing morbidity scales

    International Nuclear Information System (INIS)

    Hanlon, Alexandra L.; Schultheiss, Timothy E.; Hunt, Margie A.; Movsas, Benjamin; Peter, Ruth S.; Hanks, Gerald E.

    1997-01-01

    Purpose: Serious late morbidity (Grade (3(4))) from the conformal treatment of prostate cancer has been reported in <1% to 6% of patients based on existing late gastrointestinal (GI) morbidity scales. None of the existing morbidity scales include our most frequently observed late GI complication, which is chronic rectal bleeding requiring multiple fulgerations. This communication documents the frequency of rectal bleeding requiring multiple fulgerations and illustrates the variation in reported late serious GI complication rates by the selection of morbidity scale. Methods and Materials: Between May 1989 and December 1993, 352 patients with T1-T3 nonmetastatic prostate cancers were treated with our four-field conformal technique without special rectal blocking. This technique includes a 1-cm margin from the clinical target volume (CTV) to the planning target volume (PTV) in all directions. The median follow-up for these patients was 36 months (range 2-76), and the median center of prostate dose was 74 Gy (range 63-81). Three morbidity scales are assessed: the Radiation Therapy Oncology Group (RTOG), the Late Effects Normal Tissue Task Force (LENT), and our modification of the LENT (FC-LENT). This modification registers chronic rectal bleeding requiring at least one blood transfusion and/or more than two coagulations as a Grade 3 event. Estimates for Grade (3(4)) late GI complication rates were determined using Kaplan-Meier methodology. The duration of severe symptoms with chronic rectal bleeding is measured from the first to the last transrectal coagulation. Latency is measured from the end of radiotherapy to surgery, first blood transfusion, or third coagulation procedure. Results: Sixteen patients developed Grade (3(4)) complications by one of the three morbidity scales. Two patients required surgery (colostomy or sigmoid resection), three required multiple blood transfusions, two required one or two blood transfusions, and nine required at least three coagulations. The median duration of bleeding for those patients requiring multiple procedures was 7 months (range 3-33) and the median latency was 22 months (range 9-40). The 5-year actuarial rate of Grade (3(4)) complications by each scale are: RTOG 0.7%, LENT 2%, and FC-LENT 6%. The rate of chronic rectal bleeding increases with increasing dose and is low in patients treated with conventional techniques owing to lower doses. Conclusion: Chronic rectal bleeding requiring any blood transfusion(s) or multiple coagulation procedures is our most frequently observed complication. This complication appears late in follow-up and is present for a long duration. We believe this justifies the inclusion of chronic rectal bleeding requiring multiple coagulation procedures as a Grade 3 event in future morbidity scales. Our data illustrate that published Grade (3(4)) morbidity rates are highly dependent on the morbidity scale selected, as our data show 0.7% RTOG, 2% LENT, and 6% FC-LENT. Obviously, a uniform scale is required that includes the newly recognized serious late effects associated with the conformal treatment of prostate cancer

  13. Why Research on the Pharmacogenetics of Atypical Antipsychotic-Induced Weight Gain in Individuals with Intellectual Disabilities Is Warranted

    Science.gov (United States)

    Sleister, Heidi M.; Valdovinos, Maria Gabriela

    2011-01-01

    Weight gain is an often-observed side effect of atypical antipsychotics (AAPs) and is particularly significant in individuals with intellectual disabilities (ID). The majority of individuals treated with AAPs will gain at least 10% of their initial body weight over the course of therapy (Umbricht & Kane, 1996). One's genetic constitution is an…

  14. Does the evidence about health risks associated with nitrate ingestion warrant an increase of the nitrate standard for drinking water?

    Directory of Open Access Journals (Sweden)

    Benjamin Nigel

    2006-09-01

    Full Text Available Abstract Several authors have suggested that it is safe to raise the health standard for nitrate in drinking water, and save money on measures associated with nitrate pollution of drinking water resources. The major argument has been that the epidemiologic evidence for acute and chronic health effects related to drinking water nitrate at concentrations near the health standard is inconclusive. With respect to the chronic effects, the argument was motivated by the absence of evidence for adverse health effects related to ingestion of nitrate from dietary sources. An interdisciplinary discussion of these arguments led to three important observations. First, there have been only a few well-designed epidemiologic studies that evaluated ingestion of nitrate in drinking water and risk of specific cancers or adverse reproductive outcomes among potentially susceptible subgroups likely to have elevated endogenous nitrosation. Positive associations have been observed for some but not all health outcomes evaluated. Second, the epidemiologic studies of cancer do not support an association between ingestion of dietary nitrate (vegetables and an increased risk of cancer, because intake of dietary nitrate is associated with intake of antioxidants and other beneficial phytochemicals. Third, 2–3 % of the population in Western Europe and the US could be exposed to nitrate levels in drinking water exceeding the WHO standard of 50 mg/l nitrate, particularly those living in rural areas. The health losses due to this exposure cannot be estimated. Therefore, we conclude that it is not possible to weigh the costs and benefits from changing the nitrate standard for drinking water and groundwater resources by considering the potential consequences for human health and by considering the potential savings due to reduced costs for nitrate removal and prevention of nitrate pollution.

  15. Hepatitis A vaccine. A new convenient single-dose schedule with booster when long-term immunization is warranted

    DEFF Research Database (Denmark)

    Victor, J; Knudsen, J D; Nielsen, L P

    1994-01-01

    A total of 162 anti-HAV-negative healthy adults were immunized with a single high dose (1440 ELISA units = 1 ml) of inactivated hepatitis A vaccine and a booster was given at month 6. Antibodies were measured after modification of a commercial ELISA kit, enabling quantification of titres down to 6...

  16. When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council.

    Science.gov (United States)

    Simpson, Eric L; Bruin-Weller, Marjolein; Flohr, Carsten; Ardern-Jones, Michael R; Barbarot, Sebastien; Deleuran, Mette; Bieber, Thomas; Vestergaard, Christian; Brown, Sara J; Cork, Michael J; Drucker, Aaron M; Eichenfield, Lawrence F; Foelster-Holst, Regina; Guttman-Yassky, Emma; Nosbaum, Audrey; Reynolds, Nick J; Silverberg, Jonathan I; Schmitt, Jochen; Seyger, Marieke M B; Spuls, Phyllis I; Stalder, Jean-Francois; Su, John C; Takaoka, Roberto; Traidl-Hoffmann, Claudia; Thyssen, Jacob P; van der Schaft, Jorien; Wollenberg, Andreas; Irvine, Alan D; Paller, Amy S

    2017-10-01

    Although most patients with atopic dermatitis (AD) are effectively managed with topical medication, a significant minority require systemic therapy. Guidelines for decision making about advancement to systemic therapy are lacking. To guide those considering use of systemic therapy in AD and provide a framework for evaluation before making this therapeutic decision with the patient. A subgroup of the International Eczema Council determined aspects to consider before prescribing systemic therapy. Topics were assigned to expert reviewers who performed a topic-specific literature review, referred to guidelines when available, and provided interpretation and expert opinion. We recommend a systematic and holistic approach to assess patients with severe signs and symptoms of AD and impact on quality of life before systemic therapy. Steps taken before commencing systemic therapy include considering alternate or concomitant diagnoses, avoiding trigger factors, optimizing topical therapy, ensuring adequate patient/caregiver education, treating coexistent infection, assessing the impact on quality of life, and considering phototherapy. Our work is a consensus statement, not a systematic review. The decision to start systemic medication should include assessment of severity and quality of life while considering the individual's general health status, psychologic needs, and personal attitudes toward systemic therapies. Copyright © 2017 American Academy of Dermatology, Inc. All rights reserved.

  17. Metabolomic analysis reveals amino-acid responses to an oral glucose tolerance test in women with prior history of gestational diabetes mellitus

    Directory of Open Access Journals (Sweden)

    R. Bentley-Lewis, MD, MBA, MMSc

    2014-06-01

    Conclusions: Greater change in metabolite levels after a glucose challenge was significantly associated with a longer duration of breastfeeding and higher BMI. Further exploration of these preliminary observations and closer examination of the specific pathways implicated are warranted.

  18. Practical Aspects of the Use of Healthcare Failure Mode and Effects Analysis Tool in The Risk Management of Pediatric Emergency Department: The Scrutiny in Iran

    Directory of Open Access Journals (Sweden)

    Yasamin Molavi-Taleghani

    2018-03-01

    Full Text Available Aim: The Emergency Department is one of the most challenging wards of the hospital for studying patient safety and the prevention of treatment errors is the basic rule in the quality of health care. The present study was conducted to evaluate the selected risk processes of Pediatric Emergency of Qaem Educational Hospital in Mashhad by the Healthcare Failure Mode and Effects Analysis (HFMEA methodology. Materials and Methods: A mixed method was used to analyze failure modes and their effects with HFMEA. Five high-risk processes of the Pediatric Emergency were identified and analyzed. To classify failure modes, nursing errors in clinical management model; for classifying factors affecting error, the approved model by the United Kingdom National Health System; and for determining solutions for improvement, Theory of Inventive Problem Solving was used. Results: In 5 selected processes, 28 steps, 80 sub-processes and 254 potential failure modes were identified with HFMEA. Thirty-seven (14.5% failure modes as high-risk errors were detected and transferred to the decision tree. The most and the least failure modes were placed in the categories of care errors as 62.3%, and knowledge and skill as 8.1% respectively. Also, 23.6% of preventive measures were in the category of human resource management strategy. Conclusion: Using the proactive method of HFMEA for identifying the possible failure of treatment procedures, determining the effective cause on each failure mode and proposing the improvement strategies, has high efficiency and effectiveness.

  19. Medical professionalism of foreign-born and foreign-trained physicians under close scrutiny: A qualitative study with stakeholders in Germany

    Science.gov (United States)

    Ismail, Fatiha; Marckmann, Georg; Kuehlmeyer, Katja

    2018-01-01

    Hospitals in Germany employ increasing numbers of foreign-born and foreign-trained (FB&FT) physicians. Studies have investigated how FB&FT physicians experience their professional integration into the German healthcare system, however, the perspectives of stakeholders working with and shaping the work experiences of FB&FT physicians in German hospitals have so far been neglected. This study explores relevant stakeholders’ opinions and attitudes towards FB&FT physicians—which likely influence how these physicians settle in—and how these opinions were formed. We conducted a qualitative interview study with 25 stakeholders working in hospitals or in health policy development. The interviews were analyzed within a constructivist research paradigm using methods derived from Grounded Theory (situational analysis as well as open, axial and selective coding). We found that stakeholders tended to focus on problems in FB&FT physicians’ work performance. Participants criticized FB&FT physicians’ work for deviating from presumably shared professional standards (skill or knowledge and behavioral standards). The professional standards invoked to justify problem-focused statements comprised the definition of an ideal behavior, attitude or ability and a tolerance range that was adapted in a dynamic process. Behavior falling outside the tolerance range was criticized as unacceptable, requiring action to prevent similar deviations in the future. Furthermore, we derived three strategies (minimization, homogenization and quality management) proposed by participants to manage deviations from assumed professional standards by FB&FT physicians. We critically reflect on the social processes of evaluation and problematization and question the legitimacy of professional standards invoked. We also discuss discriminatory tendencies visible in evaluative statements of some participants as well as in some of the strategies proposed. We suggest it will be key to develop and implement better support strategies for FB&FT physicians while also addressing problematic attitudes within the receiving system to further professional integration. PMID:29447259

  20. Spatiotemporal Evolution of Ebola Virus Disease at Sub-National Level during the 2014 West Africa Epidemic: Model Scrutiny and Data Meagreness.

    Directory of Open Access Journals (Sweden)

    Eva Santermans

    Full Text Available The Ebola outbreak in West Africa has infected at least 27,443 individuals and killed 11,207, based on data until 24 June, 2015, released by the World Health Organization (WHO. This outbreak has been characterised by extensive geographic spread across the affected countries Guinea, Liberia and Sierra Leone, and by localized hotspots within these countries. The rapid recognition and quantitative assessment of localised areas of higher transmission can inform the optimal deployment of public health resources.A variety of mathematical models have been used to estimate the evolution of this epidemic, and some have pointed out the importance of the spatial heterogeneity apparent from incidence maps. However, little is known about the district-level transmission. Given that many response decisions are taken at sub-national level, the current study aimed to investigate the spatial heterogeneity by using a different modelling framework, built on publicly available data at district level. Furthermore, we assessed whether this model could quantify the effect of intervention measures and provide predictions at a local level to guide public health action. We used a two-stage modelling approach: a a flexible spatiotemporal growth model across all affected districts and b a deterministic SEIR compartmental model per district whenever deemed appropriate.Our estimates show substantial differences in the evolution of the outbreak in the various regions of Guinea, Liberia and Sierra Leone, illustrating the importance of monitoring the outbreak at district level. We also provide an estimate of the time-dependent district-specific effective reproduction number, as a quantitative measure to compare transmission between different districts and give input for informed decisions on control measures and resource allocation. Prediction and assessing the impact of control measures proved to be difficult without more accurate data. In conclusion, this study provides us a useful tool at district level for public health, and illustrates the importance of collecting and sharing data.

  1. Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1.

    Directory of Open Access Journals (Sweden)

    Alexandr N Simonov

    Full Text Available Cytochrome P450c17 (P450 17A1, CYP17A1 is a critical enzyme in the synthesis of androgens and is now a target enzyme for the treatment of prostate cancer. Cytochrome P450c17 can exhibit either one or two physiological enzymatic activities differentially regulated by cytochrome b5. How this is achieved remains unknown. Here, comprehensive in silico, in vivo and in vitro analyses were undertaken. Fluorescence Resonance Energy Transfer analysis showed close interactions within living cells between cytochrome P450c17 and cytochrome b5. In silico modeling identified the sites of interaction and confirmed that E48 and E49 residues in cytochrome b5 are essential for activity. Quartz crystal microbalance studies identified specific protein-protein interactions in a lipid membrane. Voltammetric analysis revealed that the wild type cytochrome b5, but not a mutated, E48G/E49G cyt b5, altered the kinetics of electron transfer between the electrode and the P450c17. We conclude that cytochrome b5 can influence the electronic conductivity of cytochrome P450c17 via allosteric, protein-protein interactions.

  2. The Federal Government's Presumption in Procurement Affirmative Action Programs That Americans of Thirty-Seven Nationalities or Ethnicities are Disadvantaged is on a Collision Course With Strict Scrutiny

    National Research Council Canada - National Science Library

    Sabin, Sean

    2003-01-01

    Federal affirmative action procurement programs have evolved tremendously since President Roosevelt issued an executive order that prohibited federal government contractors from engaging in discrimination...

  3. Medical professionalism of foreign-born and foreign-trained physicians under close scrutiny: A qualitative study with stakeholders in Germany.

    Science.gov (United States)

    Klingler, Corinna; Ismail, Fatiha; Marckmann, Georg; Kuehlmeyer, Katja

    2018-01-01

    Hospitals in Germany employ increasing numbers of foreign-born and foreign-trained (FB&FT) physicians. Studies have investigated how FB&FT physicians experience their professional integration into the German healthcare system, however, the perspectives of stakeholders working with and shaping the work experiences of FB&FT physicians in German hospitals have so far been neglected. This study explores relevant stakeholders' opinions and attitudes towards FB&FT physicians-which likely influence how these physicians settle in-and how these opinions were formed. We conducted a qualitative interview study with 25 stakeholders working in hospitals or in health policy development. The interviews were analyzed within a constructivist research paradigm using methods derived from Grounded Theory (situational analysis as well as open, axial and selective coding). We found that stakeholders tended to focus on problems in FB&FT physicians' work performance. Participants criticized FB&FT physicians' work for deviating from presumably shared professional standards (skill or knowledge and behavioral standards). The professional standards invoked to justify problem-focused statements comprised the definition of an ideal behavior, attitude or ability and a tolerance range that was adapted in a dynamic process. Behavior falling outside the tolerance range was criticized as unacceptable, requiring action to prevent similar deviations in the future. Furthermore, we derived three strategies (minimization, homogenization and quality management) proposed by participants to manage deviations from assumed professional standards by FB&FT physicians. We critically reflect on the social processes of evaluation and problematization and question the legitimacy of professional standards invoked. We also discuss discriminatory tendencies visible in evaluative statements of some participants as well as in some of the strategies proposed. We suggest it will be key to develop and implement better support strategies for FB&FT physicians while also addressing problematic attitudes within the receiving system to further professional integration.

  4. Psychotherapy integration under scrutiny: investigating the impact of integrating emotion-focused components into a CBT-based approach: a study protocol of a randomized controlled trial.

    Science.gov (United States)

    Babl, Anna; Grosse Holtforth, Martin; Heer, Sara; Lin, Mu; Stähli, Annabarbara; Holstein, Dominique; Belz, Martina; Egenolf, Yvonne; Frischknecht, Eveline; Ramseyer, Fabian; Regli, Daniel; Schmied, Emma; Flückiger, Christoph; Brodbeck, Jeannette; Berger, Thomas; Caspar, Franz

    2016-11-24

    This currently recruiting randomized controlled trial investigates the effects of integrating components of Emotion-Focused Therapy (EFT) into Psychological Therapy (PT), an integrative form of cognitive-behavioral therapy in a manner that is directly mirroring common integrative practice in the sense of assimilative integration. Aims of the study are to understand how both, an existing therapy approach as well as the elements to be integrated, are affected by the integration and to clarify the role of emotional processing as a mediator of therapy outcome. A total of 130 adults with a diagnosed unipolar depressive, anxiety or adjustment disorder (seeking treatment at a psychotherapy outpatient clinic) are randomized to either treatment as usual (PT) with integrated emotion-focused components (TAU + EFT) or PT (TAU). Primary outcome variables are psychopathology and symptom severity at the end of therapy and at follow up; secondary outcome variables are interpersonal problems, psychological wellbeing, quality of life, attainment of individual therapy goals, and emotional competency. Furthermore, process variables such as the quality of the therapeutic relationship are studied as well as aptitude-treatment interactions. Variables are assessed at baseline, after 8 and 16 sessions, at the end of therapy, after 25 ± 3 sessions, and at 6, 12 and 36 month follow-up. Underlying mechanisms of change are investigated. Statistical analyses will be conducted using the appropriate multilevel approaches, mainly two-level regression and growth analysis. The results of this study will indicate whether the integration of emotion-focused elements into treatment as usual increases the effectiveness of Psychological Therapy. If advantages are found, which may be limited to particular variables or subgroups of patients, recommendations for a systematic integration, and caveats if also disadvantages are detected, can be formulated. On a more abstract level, a cognitive behavioral (represented by PT) and humanistic/experiential (represented by EFT) approach will be integrated. It must be emphasized that mimicking common practice in the development and continued education of psychotherapists, EFT is not integrated as a whole, but only elements of EFT that are considered particularly important, and can be trained in an 8-day training plus supervision of therapies. ClinicalTrials.gov, NCT02822443 , 22 June 2016, retrospectively registered.

  5. The association between delusional-like experiences, and tobacco, alcohol or cannabis use: a nationwide population-based survey

    Directory of Open Access Journals (Sweden)

    Saha Sukanta

    2011-12-01

    Full Text Available Abstract Background Previous population-based studies have found that delusional-like experiences (DLE are prevalent in the community, and are associated with a wide range of mental health disorders including substance use. The aim of the study was to explore the association between DLE and three commonly used substances - tobacco, alcohol and cannabis. Methods Subjects were drawn from the Australian National Survey of Mental Health and Wellbeing 2007. The Composite International Diagnostic Interview was used to identify DLE, common psychiatric disorders, and substance use. We examined the relationship between the variables of interest using logistic regression, adjusting for potential confounding factors. Results Of 8 773 participants, 8.4% (n = 776 subjects endorsed one or more DLE. With respect to tobacco use, compared to nonusers, DLE were more common in those who (a had daily use, (b commenced usage aged 15 years or less, and (c those who smoked heavily (23 or more cigarettes per day. Participants with cannabis use disorders were more likely to endorse DLE; this association was most prominent in those with an onset of 16 years or younger. In contrast, the pattern of association between DLE versus alcohol use or dependence was less consistent, however those with early onset alcohol use disorders were more likely to endorse DLE probe items. Conclusions While cannabis use disorders have been previously linked with DLE, our findings linking alcohol and tobacco use and DLE suggest that the influence of these substances on psychosis-related outcomes warrants closer scrutiny in longitudinal prospective studies.

  6. How tobacco companies ensure prime placement of their advertising and products in stores: interviews with retailers about tobacco company incentive programmes.

    Science.gov (United States)

    Feighery, E C; Ribisl, K M; Clark, P I; Haladjian, H H

    2003-06-01

    About 81% of cigarette manufacturers' marketing expenditures in the USA is spent to promote cigarette sales in stores. Relatively little is known about how these expenditures help the manufacturers achieve their marketing goals in stores. A better understanding of how tobacco companies influence the retail environment would help researchers and tobacco control activists to monitor industry presence in stores. To describe the types of tobacco company incentive programmes offered to retailers, how these programmes impact the store environments, and possible visual indicators of retailer participation in incentive programmes. In-depth qualitative interviews with a convenience sample of 29 tobacco retailers were conducted in 2001. USA. The types and requirements of retailer incentive programmes provided by tobacco companies, and how participation in a programme alters their stores. The retailers provided insights into how tobacco companies convey promotional allowances and special offers to them and how these incentives shape the retail environment. Retailers noted that tobacco companies exert substantial control over their stores by requiring placement of products in the most visible locations, and of specific amounts and types of advertising in prime locations in the store. Retailers also described how tobacco companies reduce prices by offering them volume based discounts, "buy two, get one free" specials, and "buying down" the price of existing product. Tobacco companies are concentrating their marketing dollars at the point-of-sale to the extent that the store is their primary communication channel with customers. As a result, all shoppers regardless of age or smoking status are exposed to pro-smoking messages. Given the financial resources spent by tobacco companies in stores, this venue warrants closer scrutiny by researchers and tobacco control advocates.

  7. Tapping the grapevine: a closer look at word-of-mouth as a recruitment source.

    Science.gov (United States)

    Van Hoye, Greet; Lievens, Filip

    2009-03-01

    To advance knowledge of word-of-mouth as a company-independent recruitment source, this study draws on conceptualizations of word-of-mouth in the marketing literature. The sample consisted of 612 potential applicants targeted by the Belgian Defense. Consistent with the recipient-source framework, time spent receiving positive word-of-mouth was determined by the traits of the recipient (extraversion and conscientiousness), the characteristics of the source (perceived expertise), and their mutual relationship (tie strength). Only conscientiousness and source expertise were determinants of receiving negative word-of-mouth. In line with the accessibility-diagnosticity model, receiving positive employment information through word-of-mouth early in the recruitment process was positively associated with perceptual (organizational attractiveness) and behavioral outcomes (actual application decisions), beyond potential applicants' exposure to other recruitment sources. (c) 2009 APA, all rights reserved.

  8. A closer look at RapidArc (registered) radiosurgery plans using very small fields

    International Nuclear Information System (INIS)

    Fog, Lotte S; Rasmussen, Jens F B; Aznar, Marianne; Kjaer-Kristoffersen, Flemming; Vogelius, Ivan R; Engelholm, Svend Aage; Bangsgaard, Jens Peter

    2011-01-01

    RapidArc (registered) has become the treatment of choice for an increasing number of treatment sites in many clinics. The extensive use of multiple subfields in RapidArc (registered) treatments presents unique challenges, especially for small targets treated in few fractions. In this work, very small static fields and subsequently RapidArc (registered) and conventional plans for two targets (0.4 and 9.9 cm 3 ) were investigated. Doses from static fields 1-4 MLC leaves (0.25-1.00 cm) wide, and larger fields with 1-4 MLC leaves closed in their centres, were measured using the portal dosimeter-based QA system EPIQA (v 1.3) and gafchromic film. RapidArc and conventional plans for two tumours were then measured using EPIQA, gafchromic EBT2 film and the phantom-based QA system Delta4. Eclipse 8.6 and 8.9, grid spacings of 1.25 and 2.50 mm and a Varian HD linac were used. For static fields one MLC leaf wide, the dose was underestimated by Eclipse by as much as 53% (v 8.6, 2.5 mm grid). Eclipse underestimated the dose downstream from a few MLC leaves closed in the centre of a large MLC field by as much as 30%. Eclipse consistently overestimated the width of the penumbra by about 100%. For the conventional plans, there was good agreement between the calculated and measured dose for the 9.9 cm 3 PTV, but a 10% underdose was observed for the 0.4 cm 3 PTV. For the RapidArc (registered) plans, the measured dose for the 9.9 cm 3 PTV was in good agreement with the calculated one. However, for the 0.4 cm 3 PTV about 10% overdosing was detected (Eclipse v 8.6, 2.5 mm grid spacing). EPIQA data indicated that the measured dose profiles were overmodulated compared to the calculated one. The use of small subfields, typically a few MLC leaves wide, or larger fields with one or a few MLC leaves closed in its centre can result in significant errors in the dose calculation. The detector systems used vary in their ability to detect the discrepancies. Using a smaller grid size and newer version of Eclipse reduces the discrepancies observed in this work but does not eliminate them.

  9. EU-Korea Conference on Science and Technology Closer to Humanity-Greenness

    CERN Document Server

    Lee, Joung Hwan; Kim, Jung-Sik; EU- Korea Conference on Science and Technology

    2010-01-01

    Current research fields in science and technology were presented and discussed at the EKC2008, informing about the interests and directions of the scientists and engineers in EU countries and Korea. The Conference has emerged from the idea of bringing together EU and Korea to get to know each other better, especially in fields of science and technology.

  10. Sleep and Physiological Dysregulation: A Closer Look at Sleep Intraindividual Variability.

    Science.gov (United States)

    Bei, Bei; Seeman, Teresa E; Carroll, Judith E; Wiley, Joshua F

    2017-09-01

    Variable daily sleep (ie, higher intraindividual variability; IIV) is associated with negative health consequences, but potential physiological mechanisms are poorly understood. This study examined how the IIV of sleep timing, duration, and quality is associated with physiological dysregulation, with diurnal cortisol trajectories as a proximal outcome and allostatic load (AL) as a multisystem distal outcome. Participants are 436 adults (Mage ± standard deviation = 54.1 ± 11.7, 60.3% women) from the Midlife in the United States study. Sleep was objectively assessed using 7-day actigraphy. Diurnal cortisol was measured via saliva samples (four/day for 4 consecutive days). AL was measured using 23 biomarkers from seven systems (inflammatory, hypothalamic-pituitary-adrenal axis, metabolic glucose and lipid, cardiovascular, parasympathetic, sympathetic) using a validated bifactor model. Linear and quadratic effects of sleep IIV were estimated using a validated Bayesian model. Controlling for covariates, more variable sleep timing (p = .04 for risetime, p = .097 for bedtime) and total sleep time (TST; p = .02), but not mean sleep variables, were associated with flatter cortisol diurnal slope. More variable sleep onset latency and wake after sleep onset, later average bedtime, and shorter TST were associated with higher AL adjusting for age and sex (p-values sleep patterns were associated with blunted diurnal cortisol trajectories but not with higher multisystem physiological dysregulation. The associations between sleep IIV and overall health are likely complex, including multiple biopsychosocial determinants and require further investigation. © Sleep Research Society 2017. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.

  11. Are Brands Postmodern Relics? Taking a Closer Look at New Sacred Objects

    Directory of Open Access Journals (Sweden)

    Stéphane DUFOUR

    2011-01-01

    Full Text Available Ever since the Church lost its monopoly on the sacred, no longer able to solely determine its form or contents, the social sphere has gradually taken over this value, applying it to new human and social objects. As a result, the modes of expression of the sacred have multiplied, along with the subjective and intimate experiences of modern individualism. Among the vast number of potential manifestations of this value, to which almost everything now seems to aspire, this paper will concentrate on commercial brands as vectors of meaning, with the hypothesis that some of them seek to position themselves, in postmodern society, as new figures of the sacred. This area of study is close to that of the sociologist Adam Arvidsson, when he describes brands as religious objects. If brands are less interested in selling products than in creating an affective experience, Arvidsson assimilates them to modern relics. However, this paper goes beyond metaphors, to examine the rhetorical strategies (discourse, rituals, representations, imagery through which brands construct meaning around sacred objects. Situated between a branch of marketing which concentrates on sacralising commercial products, and a theory popular in the English-speaking world, which has illustrated how the media work to sacralise products and brands, this paper uses a communicational approach to analyse the construction of meaning, by brands looking to make themselves (appear sacred.

  12. A Closer Look at Revealed Comparative Advantage: Gross-versus Value Added Trade Flows

    OpenAIRE

    Brakman, Steven; van Marrewijk, Charles

    2015-01-01

    With the availability of international value added trade data it has become evident that gross export data and value added data do not provide the same information. Although gross exports crosses national borders and is the target of trade policy, value added data tell us what fragment in the production chain is internationally competitive in a particular country. With respect to comparative advantage the differences between the two types of data are often illustrated by means of examples usi...

  13. Closer to Nature: the Ethics of ‘Green’ Representations in Animal Product Marketing

    DEFF Research Database (Denmark)

    Borkfelt, Sune; Kondrup, Sara Vincentzen; Gjerris, Mickey

    2013-01-01

    – thus attempting to display a green, eco-, climate-, and animal friendly production. The tension between marketing and the idea of ethical consumerism is apparent as the need for independent information to make value-based choices is challenged by the liberal rules of the market and more specifically......Empirical cases from the Danish food market are examined in order to critically discuss the respective modes of communication in light of the premises of socially responsible consumer marketing. This analysis suggests that specific marketing instruments are used to sell animal products by blurring...... by the lack of a restrictive food labelling policy. The relationship between the ways in which animal welfare is communicated and emphasized through food marketing, and commonly held perceptions of acceptable standards for animal welfare, is discussed and the need for transparency in the area of animal...

  14. GETTING CLOSER TO EU STANDARDS - GEORGIA FISCAL GOVERNANCE ADJUSTMENT AND ITS IMPLICATIONS

    Directory of Open Access Journals (Sweden)

    David OBOLADZE

    2016-11-01

    Full Text Available This study focuses on fiscal governance from the perspective of developing the public finance management of Georgia. The paper investigates the fiscal governance framework in European Union countries and examines the impact of fiscal rules and budget procedures in EU countries. Well-designed fiscal frameworks are generally associated with better budgetary outcomes in terms of deficit and debt control. Following a thorough investigation of the current stance of fiscal governance in Georgia, the paper analyses the main medium and long term perspectives for Georgia to approximate with EU fiscal governance. The main objective of this paper is to provide policy guidelines needed for the appropriate and necessary reforms to ensure comprehensive, coherent and consistent fiscal governance framework for Georgia, which will improve the performance of public finance management and national economy of Georgia.

  15. Automatic quality improvement reports in the intensive care unit: One step closer toward meaningful use.

    Science.gov (United States)

    Dziadzko, Mikhail A; Thongprayoon, Charat; Ahmed, Adil; Tiong, Ing C; Li, Man; Brown, Daniel R; Pickering, Brian W; Herasevich, Vitaly

    2016-05-04

    To examine the feasibility and validity of electronic generation of quality metrics in the intensive care unit (ICU). This minimal risk observational study was performed at an academic tertiary hospital. The Critical Care Independent Multidisciplinary Program at Mayo Clinic identified and defined 11 key quality metrics. These metrics were automatically calculated using ICU DataMart, a near-real time copy of all ICU electronic medical record (EMR) data. The automatic report was compared with data from a comprehensive EMR review by a trained investigator. Data was collected for 93 randomly selected patients admitted to the ICU during April 2012 (10% of admitted adult population). This study was approved by the Mayo Clinic Institution Review Board. All types of variables needed for metric calculations were found to be available for manual and electronic abstraction, except information for availability of free beds for patient-specific time-frames. There was 100% agreement between electronic and manual data abstraction for ICU admission source, admission service, and discharge disposition. The agreement between electronic and manual data abstraction of the time of ICU admission and discharge were 99% and 89%. The time of hospital admission and discharge were similar for both the electronically and manually abstracted datasets. The specificity of the electronically-generated report was 93% and 94% for invasive and non-invasive ventilation use in the ICU. One false-positive result for each type of ventilation was present. The specificity for ICU and in-hospital mortality was 100%. Sensitivity was 100% for all metrics. Our study demonstrates excellent accuracy of electronically-generated key ICU quality metrics. This validates the feasibility of automatic metric generation.

  16. The Internal Frontier: How Art at Once Problematizes Borders and Draws us Closer to Them

    Directory of Open Access Journals (Sweden)

    Kasia Ozga

    2017-11-01

    In the artworks, migration is transformed from an isolated act to a shared human experience. The images, at once precise and indeterminate, maintain the dual symbolism of the border as barrier and as springboard, simultaneously inhibiting and enabling interactions between individuals and select geographic locations. Just as migrants lead us to re-evaluate our physical and mental borders, critical cultural production can contest the impact and staying power of borders by underscoring how establishing and overriding boundaries enable us to claim and reclaim who we are.

  17. New technology allows closer study of neutrinos; researchers credit specialized telescope

    CERN Multimedia

    Huang, N

    2002-01-01

    With the help of a newly designed telescope, University of California-Berkeley scientists and an international team of researchers have made a recent breakthrough in the study of neutrino emissions from the sun. The turning point is the Sudbury Neutrino Observatory in Canada. This telescope is the first of its kind to be sensitive enough to detect all types of neutrinos (1 page).

  18. Measuring Excellence: A Closer Look at Malcolm Baldrige National Quality Award Winners in the Manufacturing Category

    Directory of Open Access Journals (Sweden)

    Brian Cazzell

    2009-05-01

    Full Text Available The Malcolm Baldrige National Quality Award is the nation’s highest quality award. The application and review process is outlined in this work. The objective of this study was to examine the five previous winners in the Manufacturing category and to establish a firm conclusion about the award’s impact. The impact of the award was examined in several categories including financial performance, market share, and employee productivity. This study explored the accomplishments of each company and compared the common factors they shared with one another. It was found that all five companies experienced tremendous financial growth on average of 100% in either sales or revenue as a result of their dedication to quality which ultimately led to winning the MBNQA.

  19. A closer look at the probabilities of the notorious three prisoners.

    Science.gov (United States)

    Falk, R

    1992-06-01

    The "problem of three prisoners", a counterintuitive teaser, is analyzed. It is representative of a class of probability puzzles where the correct solution depends on explication of underlying assumptions. Spontaneous beliefs concerning the problem and intuitive heuristics are reviewed. The psychological background of these beliefs is explored. Several attempts to find a simple criterion to predict whether and how the probability of the target event will change as a result of obtaining evidence are examined. However, despite the psychological appeal of these attempts, none proves to be valid in general. A necessary and sufficient condition for change in the probability of the target event, following observation of new data, is proposed. That criterion is an extension of the likelihood-ratio principle (which holds in the case of only two complementary alternatives) to any number of alternatives. Some didactic implications concerning the significance of the chance set-up and reliance on analogies are discussed.

  20. Large hadron collider will get us closer to the Big Bang

    CERN Multimedia

    Khadilkar, Dhananjay

    2006-01-01

    The LHC consists of a 27 km tunnel located 100 meters under the ground near Geneva in Switzerland, lined with hundreds of superconducting magnets which will accelerate protons and subsequently collide them at mind-boggling energies of 14 terra electorn Volts. The result will be conditions prevalent just microseconds after the Big Band 15 billion years ago (1/2 page)

  1. One Step Closer to Mars with Aquaponics: Cultivating Citizen Science in K12 Schools

    Science.gov (United States)

    Kolattukudy, Maria; Puranik, Niyati; Sane, Nishant; Bisht, Kritika; Saffat, Nabeeha; Gupta, Anika; McHugh, Anne; Detweiler, Angela; Bebout, Brad; Everroad, R. Craig

    2017-01-01

    The Microbial Ecology and Biogeochemistry Research Laboratory at NASA Ames Research Center focuses primarily on the nutrient cycling and diversity of complex microbial communities. NASA is interested in the composition and functioning of microbial mat communities as these processes fundamentally shape the form and function of these analogs for the earliest forms of life on Earth (3.6 billion years ago), and likely will on other planets as well. Aquaponics systems are supported by microbial communities who perform many complex ecosystem services, including cycling nitrogen. Microbes are integral to the stability and productivity of aquaponics systems, which are analogous to microbial communities in food production systems that are essential for building efficient life support systems for long-distance space travel. Students at Meadow Park Middle School created 10 parallel aquaponics systems and took temporal microbial samples to characterize whether any macro-ecology variables impacted or changed the microbial diversity of these systems. Students additionally created a website so that other classrooms can pursue similar projects in their own schools (https://go.nasa.gov/2uJhxmF). Our lab at NASA Ames has sequenced water samples from each of the 10 tanks at 3 timepoints using a MinION sequencer. MPMS students will be involved in the analysis of the bioinformatics data generated through this collaboration. Our ongoing collaboration aims to collect and analyze data in the classroom setting that has utility for research scientists, while involving students as collaborators in the research process.

  2. The concentration of sexual behaviours in the USA: a closer examination of subpopulations.

    Science.gov (United States)

    Leichliter, Jami S; Chesson, Harrell W; Sternberg, Maya; Aral, Sevgi O

    2010-12-01

    To examine the frequency of three sexual behaviours from the most active to the least active members of the population in various subpopulations using measures of inequality. Data from a US national probability sample of the population aged 15-44 years (National Survey of Family Growth) were used. Gini coefficients and Lorenz curves were calculated in order to examine the concentration of three sexual behaviours: vaginal sex acts (past 4 weeks) and number of opposite-sex partners (past 12 months; lifetime). Analyses were conducted separately for men and women and subpopulations of interest (by age, race/ethnicity, educational level and poverty level). The sexual behaviours examined were concentrated within the most active members of the population. This concentration was most pronounced for vaginal sex acts in the past 4 weeks and lifetime opposite-sex partners, with the top 5% of each population accounting for more of the sexual behaviour than the bottom 50% of the population. Sexual behaviours were most concentrated among adolescents, the least educated and the most impoverished. Some subpopulations had similar mean or median numbers of sex acts (or sex partners), but had different degrees of concentration of these behaviours. Finally, the most impoverished men and women had the highest concentration levels for two of the three sexual behaviours (vaginal sex acts, opposite-sex partners in past 12 months). Given that sexual behaviours tended to be highly concentrated in subpopulations that are often at the highest risk of sexually transmitted infections, targeted interventions may be the most efficient method to reduce risk in these groups while minimising potential unintended consequences.

  3. Phd study of reliability and validity: One step closer to a standardized music therapy assessment model

    DEFF Research Database (Denmark)

    Jacobsen, Stine Lindahl

    The paper will present a phd study concerning reliability and validity of music therapy assessment model “Assessment of Parenting Competences” (APC) in the area of families with emotionally neglected children. This study had a multiple strategy design with a philosophical base of critical realism...... and pragmatism. The fixed design for this study was a between and within groups design in testing the APCs reliability and validity. The two different groups were parents with neglected children and parents with non-neglected children. The flexible design had a multiple case study strategy specifically...

  4. A Closer Look: Examining Teachers' Language around UDL, Inclusive Classrooms, and Intellectual Disability

    Science.gov (United States)

    Lowrey, K. Alisa; Hollingshead, Aleksandra; Howery, Kathy

    2017-01-01

    The purpose of this study was to examine the language teachers used to discuss inclusion, Universal Design for Learning (UDL), and learners with intellectual disability (ID) in an effort to better understand how teachers describe the relationship between those three. Utilizing a secondary analysis procedure, interview transcripts from seven…

  5. A Closer Look at the Akan Relativiser1 Kofi Busia Abrefa Abstract ...

    African Journals Online (AJOL)

    2016-10-31

    fishing net', Adam [ádàm̀] 'the name of a person',. Ado [àdʊ̀] 'the name of a .... for a detailed analysis on the downstepped H in Akan). Therefore, our decision to adopt Fiedler and Schwarz's (2005) representation. [â] at the ...

  6. A closer look at the size of the gaze-liking effect: a preregistered replication.

    Science.gov (United States)

    Tipples, Jason; Pecchinenda, Anna

    2018-04-30

    This study is a direct replication of gaze-liking effect using the same design, stimuli and procedure. The gaze-liking effect describes the tendency for people to rate objects as more likeable when they have recently seen a person repeatedly gaze toward rather than away from the object. However, as subsequent studies show considerable variability in the size of this effect, we sampled a larger number of participants (N = 98) than the original study (N = 24) to gain a more precise estimate of the gaze-liking effect size. Our results indicate a much smaller standardised effect size (d z  = 0.02) than that of the original study (d z  = 0.94). Our smaller effect size was not due to general insensitivity to eye-gaze effects because the same sample showed a clear (d z  = 1.09) gaze-cuing effect - faster reaction times when eyes looked toward vs away from target objects. We discuss the implications of our findings for future studies wishing to study the gaze-liking effect.

  7. Looking Closer at the Effects of Framing on Risky Choice: An Item Response Theory Analysis.

    Science.gov (United States)

    Sickar; Highhouse

    1998-07-01

    Item response theory (IRT) methodology allowed an in-depth examination of several issues that would be difficult to explore using traditional methodology. IRT models were estimated for 4 risky-choice items, answered by students under either a gain or loss frame. Results supported the typical framing finding of risk-aversion for gains and risk-seeking for losses but also suggested that a latent construct we label preference for risk was influential in predicting risky choice. Also, the Asian Disease item, most often used in framing research, was found to have anomalous statistical properties when compared to other framing items. Copyright 1998 Academic Press.

  8. Keeping Your Friends Close and Your Enemies Closer: Operational Design for a Nuclear-Armed Iran

    Science.gov (United States)

    2006-05-25

    using stealth and rapid mobility to achieve their missions.”112 Another definition of “special operation” from Lutwak et al is “self-contained acts of...war mounted by self-sufficient forces operating within hostile territory.” Lutwak et al further state “there is no absolute...kinds.” Moreover, Lutwak et al list six planning principles for successful operations. Among these is “surprise is paramount to all else.” 113

  9. Bringing science education in and out of school closer together - (Symposium) SBBq Brazil

    OpenAIRE

    Dillon, J.; King’s College London, United Kingdom

    2013-01-01

    Throughout the world, and for many decades, science-rich cultural institutions, such as zoos, aquaria, museums, and others, have collaborated with schools to provide students, teachers and families with opportunities  to expand their experiences and understanding of science. Programmes include supplementary classroom experiences; integrated core academic curricula; student science learning communities located in afterschool, summer, and weekend programmes; teacher professional development opp...

  10. Depression in later life: A closer look at the gender gap.

    Science.gov (United States)

    Acciai, Francesco; Hardy, Melissa

    2017-11-01

    Gender differences in depressive symptoms have been extensively documented, with women reporting a higher number of depressive symptoms than men. However, studies offer different explanations for why such a gap exists. The goal of the current paper is to analyze how much of the observed gender gap in depression may be attributed to (1) compositional versus (2) reporting differences or (3) differences in reactivity to adversities. We contribute to this literature by testing, net of compositional differences, whether the relationship between reporting behavior and depressive symptoms is gendered and whether accounting for the possibility of gender-specific reactivity alters the structure of the gender gap at older ages. Our results show that the observed gender gap in depression (1) only partially derives from compositional differences; (2) is not an artifact of a gender-specific reporting style; and remarkably (3) men appear more sensitive to adversities. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Prospects for Finland and Sweden to Pursue Closer Defense Cooperation With NATO

    Science.gov (United States)

    2016-09-01

    in my naval career. I would also like to recognize Professor Jeff Kline for taking special interest in my thesis topic and for providing the...Challenges for Disarmament and Peace Operations on the Political Agenda, eds. Peter Fischer - Bollin and Thomas Knirsch. VII Conference on Forte de Copacabana...Agenda, edited by Peter Fischer -Bollin and Thomas Knirsch. VII Conference on Forte de Copacabana International Security. Rio de Janeiro: Konrad-Adenauer

  12. Leader Behavior in a Police Command Bureaucracy: A Closer Look at the Quasi-Military Model.

    Science.gov (United States)

    Jermier, John M.; Berkes, Leslie J.

    1979-01-01

    Relationships among instrumental, supportive, and participative leader behaviors, task variability and task interdependence, and job satisfaction and organizational commitment were examined in a police command bureaucracy. (Author)

  13. The Impact of the Recession on Public Library Use in Colorado: A Closer Look

    Science.gov (United States)

    Lance, Keith Curry; Hofschire, Linda; Daisey, Jamie

    2011-01-01

    This report shares the statistical trends for public library use in Colorado before and since the onset of the latest recession. It also includes the voices of librarians from around the state, offering their observations and stories of how public libraries are helping in these difficult times. To determine the impact of the Great Recession on use…

  14. Financial wellness awareness: A step closer to achieve Millennium Development Goals for Pakistan.

    Science.gov (United States)

    Rehman, Rehana; Katpar, Shahjahan; Khan, Rakhshaan; Hussain, Mehwish

    2015-01-01

    To explore financial wellness (FW) awareness amongst public and private sector medical college students of Karachi. A cross sectional questionnaire based survey was conducted on medical students from 3 public and 5 private sector medical colleges of Karachi from February 2011 to December 2011. All ethnic groups having age range of 18-23 years were included. A questionnaire tailored from wellness wheel evaluated the responses of FW on a four point Likert's scale ranging from 0-3(never, sometimes, mostly, and always). Factor analysis explored common FW factors among both public and private sector medical college (MC) students. Private MC Students were better in terms of making short and long terms financial goals compared to students in public sector. The students of public MC were more focused to make and restricting to given budgets (p=0.05). The FW element of keeping savings in bank account was responded more by private MC candidates (P thrift as well (P bank accounts. They were however deficient in the knowledge of making and restricting themselves to budgets.

  15. Persistent poor glycaemic control in adult Type 1 diabetes. A closer look at the problem

    NARCIS (Netherlands)

    DeVries, J. H.; Snoek, F. J.; Heine, R. J.

    2004-01-01

    Around 25% of the adult Type 1 diabetes population is in persistent poor glycaemic control and thus at increased risk of developing microvascular complications. We here discuss correlates of long-standing poor glycaemic control and review the efficacy of clinical strategies designed to overcome

  16. Search for CP violation in B0 [and D0] decays II: A closer look

    International Nuclear Information System (INIS)

    Bigi, I.I.

    1987-04-01

    Recent findings from UA1 and ARGUS on B 0 - anti B 0 mixing brighten considerably the prospects of findings CP violation in B 0 decays. We sketch some semi-quantitative scenarios where we also address technical issues like the amount of time that is necessary. We point out that searching for the reaction Υ(4s) → B 0 anti B 0 → f 1 , f 2 , (where f/sub x/ = line integral), where f 1 , f 2 are CP eigenstates of the same CP parity has a good chance of revealing CP violation. The tight upper bound on D 0 - anti D 0 mixing, namely 0.5-1%, still allows for CP asymmetries of up to 5% in (-) D 0 → K + K - , K/sub s/K + K -

  17. Bringing the beneficiary closer: Explanations for volunteering time in Dutch private development initiatives

    NARCIS (Netherlands)

    Kinsbergen, S.; Tolsma, J.; Ruiter, S.

    2013-01-01

    In the Netherlands, charitable behavior for international development purposes is subject to important changes. Whereas established development organizations suffer from a declining support base, private development initiatives (PDIs) that execute concrete, small-scale projects within direct

  18. Moving improvement research closer to practice: the Researcher-in-Residence model

    Science.gov (United States)

    Marshall, Martin; Pagel, Christina; French, Catherine; Utley, Martin; Allwood, Dominique; Fulop, Naomi; Pope, Catherine; Banks, Victoria; Goldmann, Allan

    2014-01-01

    The traditional separation of the producers of research evidence in academia from the users of that evidence in healthcare organisations has not succeeded in closing the gap between what is known about the organisation and delivery of health services and what is actually done in practice. As a consequence, there is growing interest in alternative models of knowledge creation and mobilisation, ones which emphasise collaboration, active participation of all stakeholders, and a commitment to shared learning. Such models have robust historical, philosophical and methodological foundations but have not yet been embraced by many of the people working in the health sector. This paper presents an emerging model of participation, the Researcher-in-Residence. The model positions the researcher as a core member of a delivery team, actively negotiating a body of expertise which is different from, but complementary to, the expertise of managers and clinicians. Three examples of in-residence models are presented: an anthropologist working as a member of an executive team, operational researchers working in a front-line delivery team, and a Health Services Researcher working across an integrated care organisation. Each of these examples illustrates the contribution that an embedded researcher can make to a service-based team. They also highlight a number of unanswered questions about the model, including the required level of experience of the researcher and their areas of expertise, the institutional facilitators and barriers to embedding the model, and the risk that the independence of an embedded researcher might be compromised. The Researcher-in-Residence model has the potential to engage both academics and practitioners in the promotion of evidence-informed service improvement, but further evaluation is required before the model should be routinely used in practice. PMID:24894592

  19. Washington Meets Wall Street: A Closer Examination of the Presidential Cycle Puzzle

    NARCIS (Netherlands)

    Kraeussl, R.G.W.; Lucas, A.; Rijsbergen, D.R.; van der Sluis, P.J.; Vrugt, E.B.

    2014-01-01

    We show that the annual excess return of the S&P 500 is almost 10 percent higher during the last two years of the presidential cycle than during the first two years. This pattern cannot be explained by business-cycle variables capturing time-varying risk premia, differences in risk levels, or by

  20. Exercise-Induced Muscle Damage and Hypertrophy: A Closer Look Reveals the Jury is Still Out

    OpenAIRE

    Schoenfeld, Brad; Contreras, Bret

    2018-01-01

    This letter is a response to the paper by Damas et al (2017) titled, “The development of skeletal muscle hypertrophy through resistance training: the role of muscle damage and muscle protein synthesis,” which, in part, endeavored to review the role of exercise-induced muscle damage on muscle hypertrophy. We feel there are a number of issues in interpretation of research and extrapolation that preclude drawing the inference expressed in the paper that muscle damage neither explains nor potenti...

  1. A Closer Examination of Bipolar Disorder in School-Age Children

    Science.gov (United States)

    Bardick, Angela D.; Bernes, Kerry B.

    2005-01-01

    Children who present with severe behavioral concerns may be diagnosed as having other commonly diagnosed childhood disorders, such as attention deficit hyperactivity disorder, oppositional defiant disorder, and/or conduct disorder, among others, when they may be suffering from early-onset bipolar disorder. Awareness of the symptoms of early-onset…

  2. The march to reliable metrics: a half-century of coming closer to the truth

    NARCIS (Netherlands)

    Smit, E.G.; Neijens, P.C.

    2011-01-01

    Reach and frequency are key concepts advertisers face when selecting media for their campaigns. Around the world, the advertising industry relies on audience research for insights into how different media outlets perform on these key concepts. In this contribution, the authors discuss the

  3. Keeping Your Friends Close and Your Enemies Closer: Operational Design for a Nuclear-Armed Iran

    National Research Council Canada - National Science Library

    Umstead, Robert K

    2006-01-01

    The Islamic Republic of Iran (IRI) has pursued a nuclear program since 1985. By February 2006, with the last round of international negotiations having failed, and the International Atomic Energy Agency (IAEA...

  4. The adverse outcome pathway for skin sensitisation: Moving closer to replacing animal testing.

    Science.gov (United States)

    Schultz, Terry W; Dimitrova, Gergana; Dimitrov, Sabcho; Mekenyan, Ovanes G

    2016-10-01

    This article outlines the work of the Organisation for Economic Co-operation and Development (OECD) that led to being jointly awarded the 2015 Lush Black Box Prize. The award-winning work centred on the development of 'The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins'. This Adverse Outcome Pathway (AOP) has provided the mechanistic basis for the integration of skin sensitisation-related information. Recent developments in integrated approaches to testing and assessment, based on the AOP, are summarised. The impact of the AOP on regulatory policy and on the Three Rs are discussed. An overview of the next generation of the skin sensitisation AOP module in the OECD QSAR Toolbox, based on more-recent work at the Laboratory of Mathematical Chemistry, is also presented. 2016 FRAME.

  5. Discounting and the social cost of carbon: A closer look at uncertainty

    NARCIS (Netherlands)

    Guo, J.K.; Hepburn, C.; Tol, R.S.J.; Anthoff, D.

    2006-01-01

    Recently, in the economics literature, several papers have put forward arguments for using a declining discount rate in social-cost benefit analysis. This paper examines the impact of employing a declining discount rate on the social cost of carbon-the marginal social damage from a ton of emitted

  6. A Closer Look at Transcendence and Its Relationship to Mental Health.

    Science.gov (United States)

    Peteet, John R

    2018-04-01

    Experiences of transcendence can promote growth, creativity and altruism, but often exist in tension with critical thought and can feature problematically in certain mental disorders. Identification of the core elements in the experience of transcendence-suspending disbelief, being moved or inspired, surrendering oneself and identifying within a larger context, can clarify its relationship to psychopathology, and the basis for a clinician's role. To help individuals engage transcendent resources well, clinicians can help patients recognize how depression and trauma may interfere with engagement, masochistic and magical tendencies may distort healthy self-surrender, and vulnerability to social pressure may interfere with mature identification with a larger context or community.

  7. G protein-coupled receptor modulation with pepducins: moving closer to the clinic

    DEFF Research Database (Denmark)

    Dimond, Patricia; Carlson, Kenneth; Bouvier, Michel

    2011-01-01

    At the 2nd Pepducin Science Symposium held in Cambridge, Massachusetts, on November 4–5, 2010, investigators working in G protein–coupled receptor (GPCR) research convened to discuss progress since last year's inaugural conference. This year's symposium focused on increasing knowledge of the stru...

  8. Separate Tracks or Real Synergy? Achieving a Closer Relationship between Education and SD, Post-2015

    Science.gov (United States)

    Sterling, Stephen

    2014-01-01

    This article is based upon a longer concept paper commissioned by UNESCO in preparation for the World Conference on ESD, and entitled "Winning the Future We Want--the pivotal role of education and learning". Neither this article nor the original paper necessarily represents UNESCO'S views. The brief for this paper was to make a…

  9. Internal and External Determinants of Economic Growth: A closer look at Pakistan’s Economy

    Directory of Open Access Journals (Sweden)

    Muhammad Jamil

    2013-09-01

    Full Text Available This study aims to investigate the impact of internal and external determinants of economic growth on the economic growth of Pakistan. Major internal determinants include stock of physical capital and developmental expenditures, while external determinants include trade openness and real effective exchange rate. In doing so, study utilizes the annual time series data from 1972 to 2011. Advanced Autoregressive Distributed Lag model (ARDL approach has been employed for co-integration and error correction model (ECM for short-run results. Empirical investigations indicate that developmental expenditures, physical capital and trade openness are positively correlated with economic growth in long run, while real effective exchange rate negatively and significantly affect economic growth in long run in case of Pakistan.

  10. Avian Colibacillosis and Salmonellosis: A Closer Look at Epidemiology, Pathogenesis, Diagnosis, Control and Public Health Concerns

    Directory of Open Access Journals (Sweden)

    S. M. Lutful Kabir

    2010-01-01

    Full Text Available Avian colibacillosis and salmonellosis are considered to be the major bacterial diseases in the poultry industry world-wide. Colibacillosis and salmonellosis are the most common avian diseases that are communicable to humans. This article provides the vital information on the epidemiology, pathogenesis, diagnosis, control and public health concerns of avian colibacillosis and salmonellosis. A better understanding of the information addressed in this review article will assist the poultry researchers and the poultry industry in continuing to make progress in reducing and eliminating avian colibacillosis and salmonellosis from the poultry flocks, thereby reducing potential hazards to the public health posed by these bacterial diseases.

  11. Hidden sector dark matter and the Galactic Center gamma-ray excess: a closer look

    Science.gov (United States)

    Escudero, Miguel; Witte, Samuel J.; Hooper, Dan

    2017-11-01

    Stringent constraints from direct detection experiments and the Large Hadron Collider motivate us to consider models in which the dark matter does not directly couple to the Standard Model, but that instead annihilates into hidden sector particles which ultimately decay through small couplings to the Standard Model. We calculate the gamma-ray emission generated within the context of several such hidden sector models, including those in which the hidden sector couples to the Standard Model through the vector portal (kinetic mixing with Standard Model hypercharge), through the Higgs portal (mixing with the Standard Model Higgs boson), or both. In each case, we identify broad regions of parameter space in which the observed spectrum and intensity of the Galactic Center gamma-ray excess can easily be accommodated, while providing an acceptable thermal relic abundance and remaining consistent with all current constraints. We also point out that cosmic-ray antiproton measurements could potentially discriminate some hidden sector models from more conventional dark matter scenarios.

  12. [Pasteurella] caballi infection not limited to horses - a closer look at taxon 42 of Bisgaard

    DEFF Research Database (Denmark)

    Christensen, Henrik; Hommez, J.; Olsen, John Elmerdahl

    2006-01-01

    Aim To investigate if taxon 42 of Bisgaard isolated from pigs represents genuine [Pasteurella] caballi which has previously only been isolated from horses. Methods and Results A total of 15 field isolates from horses and pigs from 5 different countries representing three continents were to subjec...

  13. A Closer Look on Spatiotemporal Variations of Dissolved Oxygen in Waste Stabilization Ponds Using Mixed Models

    Directory of Open Access Journals (Sweden)

    Long Ho

    2018-02-01

    Full Text Available Dissolved oxygen is an essential controlling factor in the performance of facultative and maturation ponds since both take many advantages of algal photosynthetic oxygenation. The rate of this photosynthesis strongly depends on the time during the day and the location in a pond system, whose roles have been overlooked in previous guidelines of pond operation and maintenance (O&M. To elucidate these influences, a linear mixed effect model (LMM was built on the data collected from three intensive sampling campaigns in a waste stabilization pond in Cuenca, Ecuador. Within two parallel lines of facultative and maturation ponds, nine locations were sampled at two depths in each pond. In general, the output of the mixed model indicated high spatial autocorrelations of data and wide spatiotemporal variations of the oxygen level among and within the ponds. Particularly, different ponds showed different patterns of oxygen dynamics, which were associated with many factors including flow behavior, sludge accumulation, algal distribution, influent fluctuation, and pond function. Moreover, a substantial temporal change in the oxygen level between day and night, from zero to above 20 mg O2·L−1, was observed. Algal photosynthetic activity appeared to be the main reason for these variations in the model, as it was facilitated by intensive solar radiation at high altitude. Since these diurnal and spatial patterns can supply a large amount of useful information on pond performance, insightful recommendations on dissolved oxygen (DO monitoring and regulations were delivered. More importantly, as a mixed model showed high predictive performance, i.e., high goodness-of-fit (R2 of 0.94, low values of mean absolute error, we recommended this advanced statistical technique as an effective tool for dealing with high autocorrelation of data in pond systems.

  14. Looking back and moving forward: A closer look at the Dutch gender quota

    Directory of Open Access Journals (Sweden)

    Annika Galle

    2016-12-01

    Full Text Available The Dutch Civil Code stipulates that, for balanced gender representation, 30% of seats on the boards of large corporations should be occupied by women. If a company does not meet this requirement, the company is compelled to be transparent in its annual report by means of the ‘comply or explain’ principle. This article analyses the application of this rule through content analysis of the annual reports of 52 listed companies in 2012 and 49 in 2013. The article discusses whether this rule has the desired effect of creating transparency on the gender quota. The conclusion is that ‘the comply or explain’ mechanism is inadequate without further measures, including sanctions. For 2012, 21% of the companies researched made no mention in their annual report of the application of the gender quota. In 2013, 18% of the companies made no mention of it. The companies that did indicate that they did not meet the quota failed to provide the required transparency. The reasons cited for not meeting the quota are nothing more than clichéd phrases, lacking any specificity. If the Netherlands wants to achieve the European and Dutch targets with the aid of the ’comply or explain’ mechanism, the government will have to introduce additional mechanisms, including sanctions - or, alternatively, steer an entirely different course.

  15. A closer study of methanol adsorption and its impact on solute retentions in supercritical fluid chromatography.

    Science.gov (United States)

    Glenne, Emelie; Öhlén, Kristina; Leek, Hanna; Klarqvist, Magnus; Samuelsson, Jörgen; Fornstedt, Torgny

    2016-04-15

    Surface excess adsorption isotherms of methanol on a diol silica adsorbent were measured in supercritical fluid chromatography (SFC) using a mixture of methanol and carbon dioxide as mobile phase. The tracer pulse method was used with deuterium labeled methanol as solute and the tracer peaks were detected using APCI-MS over the whole composition range from neat carbon dioxide to neat methanol. The results indicate that a monolayer (4Å) of methanol is formed on the stationary phase. Moreover, the importance of using the set or the actual methanol fractions and volumetric flows in SFC was investigated by measuring the mass flow respective pressure and by calculations of the actual volume fraction of methanol. The result revealed a significant difference between the value set and the actually delivered volumetric methanol flow rate, especially at low modifier fractions. If relying only on the set methanol fraction in the calculations, the methanol layer thickness should in this system be highly overestimated. Finally, retention times for a set of solutes were measured and related to the findings summarized above concerning methanol adsorption. A strongly non-linear relationship between the logarithms of the retention factors and the modifier fraction in the mobile phase was revealed, prior to the established monolayer. At modifier fractions above that required for establishment of the methanol monolayer, this relationship turns linear which explains why the solute retention factors are less sensitive to changes in modifier content in this region. Copyright © 2016 Elsevier B.V. All rights reserved.

  16. Schizophrenia genomics and proteomics: are we any closer to biomarker discovery?

    Directory of Open Access Journals (Sweden)

    Kramer Alon

    2009-01-01

    Full Text Available Abstract The field of proteomics has made leaps and bounds in the last 10 years particularly in the fields of oncology and cardiovascular medicine. In comparison, neuroproteomics is still playing catch up mainly due to the relative complexity of neurological disorders. Schizophrenia is one such disorder, believed to be the results of multiple factors both genetic and environmental. Affecting over 2 million people in the US alone, it has become a major clinical and public health concern worldwide. This paper gives an update of schizophrenia biomarker research as reviewed by Lakhan in 2006 and gives us a rundown of the progress made during the last two years. Several studies demonstrate the potential of cerebrospinal fluid as a source of neuro-specific biomarkers. Genetic association studies are making headway in identifying candidate genes for schizophrenia. In addition, metabonomics, bioinformatics, and neuroimaging techniques are aiming to complete the picture by filling in knowledge gaps. International cooperation in the form of genomics and protein databases and brain banks is facilitating research efforts. While none of the recent developments described here in qualifies as biomarker discovery, many are likely to be stepping stones towards that goal.

  17. Tiny cells meet big questions: a closer look at bacterial cell biology.

    Science.gov (United States)

    Goley, Erin D

    2013-04-01

    While studying actin assembly as a graduate student with Matt Welch at the University of California at Berkeley, my interest was piqued by reports of surprising observations in bacteria: the identification of numerous cytoskeletal proteins, actin homologues fulfilling spindle-like functions, and even the presence of membrane-bound organelles. Curiosity about these phenomena drew me to Lucy Shapiro's lab at Stanford University for my postdoctoral research. In the Shapiro lab, and now in my lab at Johns Hopkins, I have focused on investigating the mechanisms of bacterial cytokinesis. Spending time as both a eukaryotic cell biologist and a bacterial cell biologist has convinced me that bacterial cells present the same questions as eukaryotic cells: How are chromosomes organized and accurately segregated? How is force generated for cytokinesis? How is polarity established? How are signals transduced within and between cells? These problems are conceptually similar between eukaryotes and bacteria, although their solutions can differ significantly in specifics. In this Perspective, I provide a broad view of cell biological phenomena in bacteria, the technical challenges facing those of us who peer into bacterial cells, and areas of common ground as research in eukaryotic and bacterial cell biology moves forward.

  18. A Closer Look at Cancer Imaging Tools | NIH MedlinePlus the Magazine

    Science.gov (United States)

    Skip to main content NIH MedlinePlus the Magazine NIH MedlinePlus Salud Download the Current Issue PDF [3.1 mb] Trusted Health Information from the National Institutes of Health Home Current Issue ...

  19. A closer look at racial differences in the reporting of self-assessed ...

    African Journals Online (AJOL)

    2011-10-05

    Oct 5, 2011 ... to as 'non-whites' under ... respect to the perception and reporting of SAH between members of different race groups in ... better than that of Black African persons with the health of ... straightforward to explain current racial differences in health .... the reporting of SAH, it risks the possibility of fomenting.

  20. A closer look at racial differences in the reporting of self-assessed ...

    African Journals Online (AJOL)

    2011-10-05

    Oct 5, 2011 ... this study analysed racial differences in SAH alongside ... The analysis revealed a number of differences when compared to the usual .... likely to report poorer health than a comparable person from ... face-to-face interview by a trained fieldworker. ... Data was analysed using quantitative data analysis.

  1. A closer looking at dimming and brightening in China during 1961–2005

    Directory of Open Access Journals (Sweden)

    X. Xia

    2010-05-01

    Full Text Available This study investigates dimming and brightening of surface solar radiation (SSR during 1961–2005 in China as well as its relationships to total cloud cover (TCC. This is inferred from daily ground-based observational records at 45 pyranometer stations. A statistical method is introduced to study contributions of changes in the frequency of TCC categories and their atmospheric transparency to the secular SSR trend. The surface records suggest a renewed dimming beyond 2000 in North China after the stabilization in the 1990s; however, a slight brightening appears beyond 2000 in South China. Inter-annual variability of SSR is negatively correlated with that of TCC, but there is a positive correlation between decadal variability of SSR and TCC in most cases. The dimming during 1961–1990 is exclusively attributable to decreased atmospheric transparency, a portion of which is offset by TCC frequency changes in Northeast and Southwest China. The dimming during 1961–1990 in Northwest and Southeast China primarily results from decreased atmospheric transparency under all sky conditions and the percentage of dimming stemming from TCC frequency changes is 11% in Northwest and 2% in Southeast China. Decreased atmospheric transparencies during 1991–2005 in North China in most cases lead to the dimming. TCC frequency changes also contribute to the dimming during this period in North China. This feature is more pronounced in summer and winter when TCC frequency changes can account for more than 80% of dimming. In South China, increased atmospheric transparencies lead to the brightening during 1991–2005. A substantial contribution by TCC frequency changes to the brightening is also evident in spring and autumn.

  2. A closer looking at dimming and brightening in China during 1961-2005

    Energy Technology Data Exchange (ETDEWEB)

    Xia, X. [Chinese Academy of Sciences, Beijing (China). LAGEO, Inst. of Atmospheric Physics

    2010-07-01

    This study investigates dimming and brightening of surface solar radiation (SSR) during 1961-2005 in China as well as its relationships to total cloud cover (TCC). This is inferred from daily ground-based observational records at 45 pyranometer stations. A statistical method is introduced to study contributions of changes in the frequency of TCC categories and their atmospheric transparency to the secular SSR trend. The surface records suggest a renewed dimming beyond 2000 in North China after the stabilization in the 1990s; however, a slight brightening appears beyond 2000 in South China. Inter-annual variability of SSR is negatively correlated with that of TCC, but there is a positive correlation between decadal variability of SSR and TCC in most cases. The dimming during 1961-1990 is exclusively attributable to decreased atmospheric transparency, a portion of which is offset by TCC frequency changes in Northeast and Southwest China. The dimming during 1961-1990 in Northwest and Southeast China primarily results from decreased atmospheric transparency under all sky conditions and the percentage of dimming stemming from TCC frequency changes is 11% in Northwest and 2% in Southeast China. Decreased atmospheric transparencies during 1991- 2005 in North China in most cases lead to the dimming. TCC frequency changes also contribute to the dimming during this period in North China. This feature is more pronounced in summer and winter when TCC frequency changes can account for more than 80% of dimming. In South China, increased atmospheric transparencies lead to the brightening during 1991-2005. A substantial contribution by TCC frequency changes to the brightening is also evident in spring and autumn. (orig.)

  3. The auditory dynamic attending theory revisited: A closer look at the pitch comparison task.

    Science.gov (United States)

    Bauer, Anna-Katharina R; Jaeger, Manuela; Thorne, Jeremy D; Bendixen, Alexandra; Debener, Stefan

    2015-11-11

    The dynamic attending theory as originally proposed by Jones, 1976. Psychol. Rev. 83(5), 323-355 posits that tone sequences presented at a regular rhythm entrain attentional oscillations and thereby facilitate the processing of sounds presented in phase with this rhythm. The increased interest in neural correlates of dynamic attending requires robust behavioral indicators of the phenomenon. Here we aimed to replicate and complement the most prominent experimental implementation of dynamic attending (Jones et al., 2002. Psychol. Sci. 13(4), 313-319). The paradigm uses a pitch comparison task in which two tones, the initial and the last of a longer series, have to be compared. In-between the two, distractor tones with variable pitch are presented, at a regular pace. A comparison tone presented in phase with the entrained rhythm is hypothesized to lead to better behavioral performance. Aiming for a conceptual replication, four different variations of the original paradigm were created which were followed by an exact replication attempt. Across all five experiments, only 40 of the 140 tested participants showed the hypothesized pattern of an inverted U-shaped profile in task accuracy, and the group average effects did not replicate the pattern reported by Jones et al., 2002. Psychol. Sci. 13(4), 313-319 in any of the five experiments. However, clear evidence for a relationship between musicality and overall behavioral performance was found. This study casts doubt on the suitability of the pitch comparison task for demonstrating auditory dynamic attending. We discuss alternative tasks that have been shown to support dynamic attending theory, thus lending themselves more readily to studying its neural correlates. This article is part of a Special Issue entitled SI: Prediction and Attention. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

  4. The best of shape: 3-D scanning in South Africa gives aggregate a closer look

    CSIR Research Space (South Africa)

    Anochie-Boateng, Joseph

    2011-09-01

    Full Text Available The author of this article is conducting research in South Africa which addresses the difficulties in pavement design in developing methods and procedures for accurate quantification of aggregate shape and surface properties, which are well known...

  5. Artificial versus Natural Reuse of CO2 for DME Production: Are We Any Closer?

    Directory of Open Access Journals (Sweden)

    Mariano Martín

    2017-04-01

    Full Text Available This work uses a mathematical optimization approach to analyze and compare facilities that either capture carbon dioxide (CO2 artificially or use naturally captured CO2 in the form of lignocellulosic biomass toward the production of the same product, dimethyl ether (DME. In nature, plants capture CO2 via photosynthesis in order to grow. The design of the first process discussed here is based on a superstructure optimization approach in order to select technologies that transform lignocellulosic biomass into DME. Biomass is gasified; next, the raw syngas must be purified using reforming, scrubbing, and carbon capture technologies before it can be used to directly produce DME. Alternatively, CO2 can be captured and used to produce DME via hydrogenation. Hydrogen (H2 is produced by splitting water using solar energy. Facilities based on both photovoltaic (PV solar or concentrated solar power (CSP technologies have been designed; their monthly operation, which is based on solar availability, is determined using a multi-period approach. The current level of technological development gives biomass an advantage as a carbon capture technology, since both water consumption and economic parameters are in its favor. However, due to the area required for growing biomass and the total amount of water consumed (if plant growing is also accounted for, the decision to use biomass is not a straightforward one.

  6. Confronting zoonoses through closer collaboration between medicine and veterinary medicine (as 'one medicine').

    Science.gov (United States)

    Kahn, Laura H; Kaplan, Bruce; Steele, James H

    2007-01-01

    In the 19th century, the concept of 'one medicine' was embraced by leaders in the medical and veterinary medical communities. In the 20th century, collaborative efforts between medicine and veterinary medicine diminished considerably. While there have been some notable exceptions, such as Calvin W. Schwabe's proposal for unifying human and veterinary medicine and joint efforts by the Food and Agriculture Organization and World Health Organization to control zoonotic diseases, 'one medicine' has languished in the modern milieu of clinical care, public health, and biomedical research. Risks of zoonotic disease transmission are rarely discussed in clinical care which is of particular concern if humans and/or animals are immunosuppressed. Physicians and veterinarians should advise their patients and pet-owning clients that some animals should not be pets. The risk of zoonotic disease acquisition can be considerable in the occupational setting. Collaborative efforts in biomedical research could do much to improve human and animal health. As the threat of zoonotic diseases continues to increase in the 21st century, medicine and veterinary medicine must revive 'one medicine' in order to adequately address these challenges. 'One medicine' revival strategies must involve medical and veterinary medical education, clinical care, public health and biomedical research.

  7. “Click for Closer Care”: A Content Analysis of Community Pharmacy Websites in Four Countries

    NARCIS (Netherlands)

    Zwier, S.

    Background: Combinations of professional and commercial communication are typically very controversial, particularly in health care communication on the Internet. Websites of licensed community pharmacies on the other hand tend to raise remarkably little controversy, although they typically contain

  8. Closer clutch inspection—quicker egg ejection: timing of host responses toward parasitic eggs

    Czech Academy of Sciences Publication Activity Database

    Požgayová, Milica; Procházka, Petr; Polačiková, Lenka; Honza, Marcel

    2011-01-01

    Roč. 22, č. 1 (2011), s. 46-51 ISSN 1045-2249 R&D Projects: GA AV ČR IAA600930605; GA AV ČR IAA600930903; GA ČR(CZ) GD524/05/H536; GA MŠk LC06073 Institutional research plan: CEZ:AV0Z60930519 Keywords : Acrocephalus arundinaceus * brood parasitism * egg discrimination * egg ejection time * great reed warbler * nest inspection Subject RIV: EG - Zoology Impact factor: 3.083, year: 2011

  9. A CLOSER LOOK AT (LACK OF OBVIATION PHENOMENA IN ROMANIAN SUBJUNCTIVE COMPLEMENTS

    Directory of Open Access Journals (Sweden)

    Maria Aurelia Cotfas

    2011-05-01

    Full Text Available The paper looks at Romanian subjunctive complements selected by volitional verbs and considers the interpretation of their null subjects and why – unlike the case of other Romance languages – these can co-refer with a main clause antecedent (what has been called “lack of obviation” in the literature. What we want to show (against claims made by Roussou 2001 and Landau 2004 is that null subject ca-subjunctives in Romanian do not trigger obviation (disjoint subjects and that obviation effects in such contexts can appear not because of ca, but in cases where the subject of the subjunctive complement is an overt 3rd person pronoun whose phi-features match those of the main clause subject. Supporting evidence for the different interpretation of null vs. overt pronouns comes from Reinhart’s (1999, 2000 variable binding vs. co-valuation (Rule I and Ariel’s (1991, 1994 Accessibility Theory.

  10. A closer look at (lack of obviation phenomena in Romanian subjunctive complements

    Directory of Open Access Journals (Sweden)

    Maria Aurelia Cotfas

    2011-01-01

    Full Text Available The paper looks at Romanian subjunctive complements selected by volitional verbs and considers the interpretation of their null subjects and why – unlike the case of other Romance languages – these can co-refer with a main clause antecedent (what has been called “lack of obviation” in the literature. What we want to show (against claims made by Roussou 2001 and Landau 2004 is that null subject ca-subjunctives in Romanian do not trigger obviation (disjoint subjects and that obviation effects in such contexts can appear not because of ca, but in cases where the subject of the subjunctive complement is an overt 3rd person pronoun whose phi-features match those of the main clause subject. Supporting evidence for the different interpretation of null vs. overt pronouns comes from Reinhart’s (1999, 2000 variable binding vs. co-valuation (Rule I and Ariel’s (1991, 1994 Accessibility Theory.

  11. Wildlife trade in Brazil: a closer look at wild pets welfare issues.

    Science.gov (United States)

    Kuhnen, V V; Kanaan, V T

    2014-02-01

    Wild animals have been kept as pets for centuries, in Brazil companionship is one of the main reasons why wild species are legally bred and traded. This paper is an attempt to call the attention for problems concerning the welfare of wild pets involved in the trading system in Brazil. Some issues presented are: a) the significant increase in the number of wildlife breeders and traders and the difficulties faced by of the Brazilian government in controlling this activity; b) the main welfare issues faced by breeders and owners of wild pets; and c) the destination of wild pets no longer wanted. Finally, some recommendations are made having the welfare of the animals as a priority.

  12. A Closer Look at the Pangasinan Verbal Affixes maN- and oN-

    Directory of Open Access Journals (Sweden)

    Francisco C. Rosario, Jr.

    2017-12-01

    Full Text Available The main objective of this paper is to present a simple description and discussion of the semantic and grammatical functions of the Pangasinan verbal affixes maN- and oN-. The semantic description of the functions of these Pangasinan verbal affixes was based on the meanings derived from the combination of the verbal affix and a list of compatible verb roots. Verb roots that are semantically related were also identified and classified to present an evidence that support the view that in particular semantic classes of verb roots, the root-affix correspondence is regular. The grammatical functions, on the other hand, were determined based on the type of arguments selected by the verbs, which were derived using the two verbal affixes. At least 370 verb roots were analyzed to identify the semantic and grammatical functions of these verbal affixes.

  13. Labeling of genetically modified food: closer to reality in the United States?

    Science.gov (United States)

    Wohlers, Anton E

    2013-01-01

    Within the broader context of several related biotech developments, including the proliferation of GM food in American grocery stories, the recent decision by Whole Foods Market, Inc. to require the labeling of all genetically modified (GM) organism products sold in its stores by 2018, and the development of GM animals for consumption, this essay asks whether the United States is inching towards a policy of mandatory GM food labeling. The analysis highlights aspects of the biotechnology policy debate in the United States and European Union, and traces public opinion as well as grassroots and legislative efforts aimed at GM food labeling. Findings show that activities at the federal level do not suggest any major regulatory changes regarding labeling in the near future; however, a growing number of individual states are considering GM food labeling legislation and political momentum in favor of labeling has picked up in recent years. Voluntary labeling by food companies may also become increasingly common.

  14. The crossover of work engagement between working couples : a closer look at the role of empathy

    NARCIS (Netherlands)

    Bakker, A.B.; Demerouti, E.

    2009-01-01

    Purpose – The purpose of this paper is to examine the role of empathy (empathic concern and perspective taking) in the crossover process. Specifically, it aims to test whether empathy moderates the crossover effect of women's work engagement to their men's work engagement. Additionally, it seeks to

  15. Bringing employees closer : the effect of proximity on communication when teams function under time pressure

    NARCIS (Netherlands)

    Chong, S.F.D.; Eerde, van W.; Rutte, C.G.; Chai, K.H.

    2012-01-01

    Some studies have assumed close proximity to improve team communication on the premise that reduced physical distance increases the chance of contact and information exchange. However, research showed that the relationship between team proximity and team communication is not always straightforward

  16. Is the US Investing Wisely in Latin America? Let Us Take a Closer Look at Ecuador

    Science.gov (United States)

    2009-04-01

    voluntad política del Ecuador para profundizar los lazos con Iran”, www.elciudadano.gov.ec 74 Ibid 75 CRS Report for Congress, “Venezuela: Political...www.elciudadano.gov.ec, January 9, 2009. El Ciudadano. “Presidente Correa destacó la voluntad política del Ecuador para profundizar los lazos con

  17. A closer look at acute heart failure: Putting Portuguese and European data into perspective.

    Science.gov (United States)

    Fonseca, Cândida; Araújo, Inês; Marques, Filipa; Brás, Daniel; Bettencourt, Paulo

    2016-05-01

    Acute heart failure (AHF) is a heterogeneous clinical syndrome requiring urgent therapy. The prognosis is poor after the index hospitalization, with a high risk for rehospitalization and early death. The costs of managing AHF are thus increasing rapidly. A literature review was performed to gather and compare data on prevalence and treatment and to identify gaps in AHF management, based on European and Portuguese studies. A literature search from 1995 to 2014 was conducted in selected databases (BIOSIS Previews, EMBASE and Ovid MEDLINE). Seven Portuguese and nine European studies were analyzed. The mean age of AHF patients was ≥65 years and 30-50% were women. Coronary artery disease (42.3% vs. 61.9%) and hypertension (53.3% vs. 76.7%) were identified as primary etiologies in Europe and in Portugal. Similar proportions of heart failure with preserved ejection fraction were found in the Portuguese (19.9-44.7%) and European (32.8-39.1%) studies. Overall, all-cause mortality rates were comparable (six months: 9.3-25.5% vs. 13.5-27.4%; one year: 15.9-31% vs. 17.4-46.5%), as was in-hospital mortality (5.5-14% vs. 3.8-12%) in Portuguese and European studies, respectively. Length of stay was comparable. The studies were performed in very different hospital settings and data on treatment were scarce. Gaps were identified in treatment and clinical pathways of patients with AHF. Based on the results of this review, collection and investigation of data on the disease and treatment solutions, training in disease management, and improved organization of healthcare should be the subject of further investment. Copyright © 2016 Sociedade Portuguesa de Cardiologia. Published by Elsevier España. All rights reserved.

  18. Preferences of newborn mice for odours indicating closer genetic relatedness: is experience necessary?

    Science.gov (United States)

    Todrank, Josephine; Busquet, Nicolas; Baudoin, Claude; Heth, Giora

    2005-10-07

    Evidence from studies with adult rodents indicates that individual recognition enables distinctions between familiar individuals irrespective of relatedness (but including close kin) and a separate mechanism enables discriminations based on genetic relatedness without prior familiarity. For example, adult mice could assess the extent of their genetic relatedness to unfamiliar individuals using perceptual similarities between their individual odours. The ontogeny of this genetic relatedness assessment mechanism, however, had not been investigated. Here, in two-choice tests, newborn mice differentially preferred odours of more genetically similar lactating females (paternal aunts to unrelated conspecific and conspecific to heterospecific) even without prior direct exposure to adults with the tested genotypes. The results provide a direct demonstration of genetic relatedness assessment abilities in newborns and show that experience with parental odours is not necessary for genetic relatedness distinctions. Future studies will be necessary to determine whether exposure to odours of other foetuses in the womb or littermates shortly after birth affects this genetic relatedness assessment process.

  19. Environmental and Financial Performance of Fossil Fuel Firms : A Closer Inspection of their Interaction

    NARCIS (Netherlands)

    Gonenc, Halit; Scholtens, Bert

    We investigate the relationship between environmental and financial performance of fossil fuel firms. To this extent, we analyze a large international sample of firms in chemicals, oil, gas, and coal with respect to several environmental indicators in relation to financial performance for the period

  20. A closer look at forests on the edge: future development on private forests in three states.

    Science.gov (United States)

    Eric White; Rhonda. Mazza

    2008-01-01

    Privately owned forests provide many public benefits, including clean water and air, wildlife habitat, and recreational opportunities. By 2030, 44.2 million acres of rural private forest land across the conterminous United States are projected to experience substantial increases in residential development. As housing density increases, the public benefits provided by...

  1. Personality and Party Ideology Among Politicians. A Closer Look at Political Elites From Canada and Belgium

    Science.gov (United States)

    Joly, Jeroen K.; Hofmans, Joeri; Loewen, Peter

    2018-01-01

    We examined the relationship between Big Five personality and the political ideology of elected politicians. To this end, we studied 303 politicians from Flanders, Wallonia, and Canada, relating their self-reported Big Five scores to a partisanship-based measure of political ideology. Our findings show that, in line with the congruency model of personality, Openness to Experience is the best and most consistent correlate of political ideology, with politicians high on Openness to Experience being more likely to be found among the more progressive left-wing political parties. PMID:29719525

  2. Estimating misclassification error: a closer look at cross-validation based methods

    Directory of Open Access Journals (Sweden)

    Ounpraseuth Songthip

    2012-11-01

    Full Text Available Abstract Background To estimate a classifier’s error in predicting future observations, bootstrap methods have been proposed as reduced-variation alternatives to traditional cross-validation (CV methods based on sampling without replacement. Monte Carlo (MC simulation studies aimed at estimating the true misclassification error conditional on the training set are commonly used to compare CV methods. We conducted an MC simulation study to compare a new method of bootstrap CV (BCV to k-fold CV for estimating clasification error. Findings For the low-dimensional conditions simulated, the modest positive bias of k-fold CV contrasted sharply with the substantial negative bias of the new BCV method. This behavior was corroborated using a real-world dataset of prognostic gene-expression profiles in breast cancer patients. Our simulation results demonstrate some extreme characteristics of variance and bias that can occur due to a fault in the design of CV exercises aimed at estimating the true conditional error of a classifier, and that appear not to have been fully appreciated in previous studies. Although CV is a sound practice for estimating a classifier’s generalization error, using CV to estimate the fixed misclassification error of a trained classifier conditional on the training set is problematic. While MC simulation of this estimation exercise can correctly represent the average bias of a classifier, it will overstate the between-run variance of the bias. Conclusions We recommend k-fold CV over the new BCV method for estimating a classifier’s generalization error. The extreme negative bias of BCV is too high a price to pay for its reduced variance.

  3. Research that Helps Move Us Closer to a World where Each Child Thrives.

    Science.gov (United States)

    Diamond, Adele

    Schools are curtailing programs in arts, physical exercise, and play so more time and resources can be devoted to academic instruction. Yet indications are that the arts (e.g., music, dance, or theatre) and physical activity (e.g., sports, martial arts, or youth circus) are crucial for all aspects of children's development - including success in school . Thus in cutting those activities, schools may be impeding academic success, not aiding it. Correlational and retrospective studies have laid the groundwork, as have moving personal accounts, case studies, and theoretical arguments. The time is ripe for rigorous studies to investigate causality (Do arts and physical activities actually produce academic benefits or would kids in those activities have succeeded anyway?) and what characteristics of programs account for the benefits. Instead of simply claiming that the arts and/or physical activities can transform kids' lives, that needs to be demonstrated, and granting agencies need to be more open to funding rigorous research of real-world arts and physical-activity programs.

  4. A Closer Look: The Representation of Slavery in the "Dear America" Series

    Science.gov (United States)

    Williams, T. Lee

    2009-01-01

    The "Dear America" series is one of the most successful brands in children's literature. It inspired the publisher, Scholastic Books, to produce four related series that include more than 90 titles. Each book seeks to personalize important events in American history through the diary of a fictionalized main character. According to the publisher,…

  5. Reliability of Portfolio: A Closer Look at Findings from Recent Publications

    Science.gov (United States)

    Oskay, Ozge Ozyalcin; Schallies, Michael; Morgil, Inci

    2008-01-01

    In this review article, conventional portfolio assessment and new developments in portfolio assessment are investigated. The concept of portfolio, portfolio building steps, contents of portfolio, evaluation of portfolio, advantages, disadvantages and concerns in using portfolio as well as validity and reliability of portfolio assessment are…

  6. A closer look at the relationship between the default network, mind wandering, negative mood, and depression.

    Science.gov (United States)

    Konjedi, Shaghayegh; Maleeh, Reza

    2017-08-01

    By a systematic analysis of the current literature on the neural correlates of mind wandering, that is, the default network (DN), and by shedding light on some determinative factors and conditions which affect the relationship between mind wandering and negative mood, we show that (1) mind wandering per se does not necessarily have a positive correlation with negative mood and, on the higher levels, depression. We propose that negative mood as a consequence of mind wandering generally depends on two determinative conditions, that is, whether mind wandering is with or without meta-awareness and whether mind wandering occurs during high or low vigilance states; (2) increased activity of the DN is not necessarily followed by an increase in unhappiness and depression. We argue that while in some kinds of meditation practices we witness an increase in the structure and in the activity of the DN, no increase in unhappiness and depression is observed.

  7. "Click for Closer Care": A Content Analysis of Community Pharmacy Websites in Four Countries.

    Science.gov (United States)

    Zwier, Sandra

    2017-06-14

    Combinations of professional and commercial communication are typically very controversial, particularly in health care communication on the Internet. Websites of licensed community pharmacies on the other hand tend to raise remarkably little controversy, although they typically contain controversial combinations of clinical and commercial services previously unprecedented in professional health care communication. The aim of this study was to fill the void of knowledge about the combination of clinical and commercial services presented on the websites of licensed community pharmacies. A content analysis of clinical and commercial services presented in a random sample of 200 licensed community pharmacy websites from Great Britain, the Netherlands, the Canadian provinces British Columbia and Manitoba, and the Australian states New South Wales and Western Australia was conducted. The top five specific services mentioned on the community pharmacy websites were cosmetic products (126/200, 63.0%), medication refill request options (124/200, 62.0%), over-the-counter medicine (115/200, 57.5%), complementary and alternative medicine (107/200, 53.5%), and home medical aids (98/200, 49.0%). On average, 72.5% (145/200) of the community pharmacy websites across the 4 countries included a combination of clinical and commercial services. A combination of clinical and commercial services was more often present on chain pharmacy websites (120/147, 82.8%) than single pharmacy websites (25/53, 47%; Ppharmacy websites, followed by the Australian, British, and Dutch pharmacy websites, respectively (Ppharmacies' homepages contained a combination of clinical and commercial images (107/200, 53.5%), and almost half of the homepage menus contained a combination of clinical and commercial items (99/200, 49.5%). The latter were, again, more common on chain pharmacy than single pharmacy websites (Ppharmacies in Great Britain, the Netherlands, Canada, and Australia combine clinical services with commercial services. Previous research into the presence of a combination of commercial and professional services suggests that such a combination may lead to increased interest in commercial services that may be unnecessary or inappropriate to patients' health. ©Sandra Zwier. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 14.06.2017.

  8. Bringing healthcare closer to home: one province's approach to home care.

    Science.gov (United States)

    Witmer, E

    2000-01-01

    Ontario is implementing a number of steps to address the growing need for home care and continuing care. One of these steps is the establishment of Ontario's network of 43 Community Care Access Centres (CCACs). Responsible for aiding Ontario residents who seek community-based long-term healthcare, CCACs coordinate access to home services such as nursing and homemaking, manage placement to long-term care facilities and provide information and referral services. In 2000/01 the Ontario government announced 92.5 million Canadian dollars in new funding for long-term community services. This new funding includes 70.1 million Canadian dollars for CCACs. During this time, the provincial government will spend more than 1.6 billion Canadian dollars for long-term-care community-based services. Of this amount, 1.1 Canadian dollars billion will go to CCACs. Community Care Access Centres served more than 400,000 people in 1998/99 and are estimated to serve more than 420,000 in 2000/01. The administrative funds saved by this province-wide system are reinvested in front-line health services.

  9. Covenants Not to Compete in Employment Contracts: Worth a Closer Look in the Classroom

    Science.gov (United States)

    Murphy, Tonia Hap

    2015-01-01

    The topic of noncompetes is a rich one for a business law or legal environment course. It presents opportunities to tie law and policy, law and ethics, law and strategy. It exemplifies the challenges businesses and employees may face in a changing, complex, uncertain legal environment. Accordingly, this article provides materials on noncompetes…

  10. Closer to the Core: A Multi-Informant Longitudinal Perspective on Personality

    NARCIS (Netherlands)

    Luan, Ziyan

    2018-01-01

    As a multifaceted construct, personality is like a mountain. It may take on different shapes when looking from different perspectives – far or near, high or low, outside or inside. Its view may be colored when looking through different lenses. The current personality literature is primarily built on

  11. Are we closer to the vision? A proposed framework for incorporating omics into environmental assessments.

    Science.gov (United States)

    Martyniuk, Christopher J

    2018-04-01

    Environmental science has benefited a great deal from omics-based technologies. High-throughput toxicology has defined adverse outcome pathways (AOPs), prioritized chemicals of concern, and identified novel actions of environmental chemicals. While many of these approaches are conducted under rigorous laboratory conditions, a significant challenge has been the interpretation of omics data in "real-world" exposure scenarios. Clarity in the interpretation of these data limits their use in environmental monitoring programs. In recent years, one overarching objective of many has been to address fundamental questions concerning experimental design and the robustness of data collected under the broad umbrella of environmental genomics. These questions include: (1) the likelihood that molecular profiles return to a predefined baseline level following remediation efforts, (2) how reference site selection in an urban environment influences interpretation of omics data and (3) what is the most appropriate species to monitor in the environment from an omics point of view. In addition, inter-genomics studies have been conducted to assess transcriptome reproducibility in toxicology studies. One lesson learned from inter-genomics studies is that there are core molecular networks that can be identified by multiple laboratories using the same platform. This supports the idea that "omics-networks" defined a priori may be a viable approach moving forward for evaluating environmental impacts over time. Both spatial and temporal variability in ecosystem structure is expected to influence molecular responses to environmental stressors, and it is important to recognize how these variables, as well as individual factor (i.e. sex, age, maturation), may confound interpretation of network responses to chemicals. This mini-review synthesizes the progress made towards adopting these tools into environmental monitoring and identifies future challenges to be addressed, as we move into the next era of high throughput sequencing. A conceptual framework for validating and incorporating molecular networks into environmental monitoring programs is proposed. As AOPs become more defined and their potential in environmental monitoring assessments becomes more recognized, the AOP framework may prove to be the conduit between omics and penultimate ecological responses for environmental risk assessments. Copyright © 2018 Elsevier B.V. All rights reserved.

  12. Bringing a Global Issue Closer to Home: The OSU Climate Change Webinar Series

    Science.gov (United States)

    Jentes Banicki, J.; Dierkes, C.

    2012-12-01

    When people think about the effects of climate change, many will still picture that iconic lone polar bear clinging to a shrinking iceberg in Antarctica. But many don't realize that the impacts that we will face here at home could also be severe, directly affecting the food we eat, the health we have, and the natural environments we appreciate. To help better explain and ultimately localize those impacts for Great Lakes residents, 10 departments within Ohio State University partnered in 2009 to create the Global Change, Local Impact webinar series. The monthly series brings in experts from around the Great Lakes region to discuss issues and impacts we will encounter regionally as our climate changes. Originally designed as a small series for Ohioans, the series has broadened to focus on Great Lakes-related issues, with more than 4,500 attendees representing 500 organizations in governmental agencies, academia, non-profit groups, private industry, and the legislature from around the country. Over the past two years, the OSU Climate Team expanded its educational reach by partnering with external groups like the Centers for Disease Control and Prevention, Great Lakes Regional Water Program, National Oceanic and Atmospheric Administration, and the Great Lakes Sea Grant Network to help deliver the most knowledgeable experts and resources for each Great Lake-focused climate topic and archive those resources on its www.changingclimate.osu.edu web site. As a result of these collaborative efforts, participants say the webinars are one of their primary resources for climate-related research information in the region, with 80-90% polled saying they use this information as an unbiased resource to help not only understand how climate change could affect local concerns like public health, agriculture, and infrastructure, but what they in their vocations and daily lives can do to prepare for it. For scientists and practitioners, this series serves as the perfect low carbon venue to share climate research and response projects with a diverse group of individuals. For webinar attendees, real-time and recorded webinars provide access to current research data and the ability to interact with like-minded colleagues working to mitigate and adapt to regional impacts of climate change. This presentation will provide an overview of this ongoing project, as well as the available online climate resources and webinar survey results from the series.

  13. NO to ¥E$? Enhancing Economic Integration in East Asia through Closer Monetary Cooperation

    OpenAIRE

    Lamberte, Mario B.; Milo, Melanie S.; Pontines, Victor

    2001-01-01

    This paper has reviewed four major developments in the last 30 years: the collapse of the Bretton Woods arrangements; deepening of economic integration worldwide; the frequency and severity of the crises that affected not only developing economies but developed economies as well; and the formation of the Euroland. Against this background was the increasing intra-regional trade and investment in East Asia. Existing empirical studies generally show that East Asia has satisfied the economic crit...

  14. A Closer Look at the Brain As Related to Teachers and Learners.

    Science.gov (United States)

    Haglund, Elaine

    1981-01-01

    Recent findings related to neurological research include: (1) the Proster Theory implies that the brain works by sets of programs or prosters; (2) the Brain Growth Spurts theory defines the growth of the brain in spurts with cycles of rest; and (3) in the Hemispheric Specialization Theory, the left and right hemispheres of the brain have specific…

  15. A Closer Look at the Design of Cutterheads for Hard Rock Tunnel-Boring Machines

    Directory of Open Access Journals (Sweden)

    Jamal Rostami

    2017-12-01

    Full Text Available The success of a tunnel-boring machine (TBM in a given project depends on the functionality of all components of the system, from the cutters to the backup system, and on the entire rolling stock. However, no part of the machine plays a more crucial role in the efficient operation of the machine than its cutterhead. The design of the cutterhead impacts the efficiency of cutting, the balance of the head, the life of the cutters, the maintenance of the main bearing/gearbox, and the effectiveness of the mucking along with its effects on the wear of the face and gage cutters/muck buckets. Overall, cutterhead design heavily impacts the rate of penetration (ROP, rate of machine utilization (U, and daily advance rate (AR. Although there has been some discussion in commonly available publications regarding disk cutters, cutting forces, and some design features of the head, there is limited literature on this subject because the design of cutterheads is mainly handled by machine manufacturers. Most of the design process involves proprietary algorithms by the manufacturers, and despite recent attention on the subject, the design of rock TBMs has been somewhat of a mystery to most end-users. This paper is an attempt to demystify the basic concepts in design. Although it may not be sufficient for a full-fledged design by the readers, this paper allows engineers and contractors to understand the thought process in the design steps, what to look for in a proper design, and the implications of the head design on machine operation and life cycle. Keywords: TBM cutterhead design, Cutterhead layout, Disk cutters, Cutting pattern, TBM efficiency

  16. Feeling Closer to the Future Self and Doing Better: Temporal Psychological Mechanisms Underlying Academic Performance

    Science.gov (United States)

    Adelman, Robert Mark; Herrmann, Sarah D.; Bodford, Jessica E.; Barbour, Joseph E.; Graudejus, Oliver; Okun, Morris A.; Kwan, Virginia S. Y.

    2017-01-01

    This research examined the function of future self-continuity and its potential downstream consequences for academic performance through relations with other temporal psychological factors and self-control. We also addressed the influence of cultural factors by testing whether these relations differed by college generation status. Undergraduate…

  17. A closer look at visually guided saccades in autism and Asperger’s disorder

    Directory of Open Access Journals (Sweden)

    Beth eJohnson

    2012-11-01

    Full Text Available Motor impairments have been found to be a significant clinical feature associated with autism and Asperger’s disorder (AD in addition to core symptoms of communication and social cognition deficits. Motor deficits in high-functioning autism (HFA and AD may differentiate these disorders, particularly with respect to the role of the cerebellum in motor functioning. Current neuroimaging and behavioural evidence suggests greater disruption of the cerebellum in HFA than AD. Investigations of ocular motor functioning have previously been used in clinical populations to assess the integrity of the cerebellar networks, through examination of saccade accuracy and the integrity of saccade dynamics. Previous investigations of visually guided saccades in HFA and AD have only assessed basic saccade metrics, such as latency, amplitude and gain, as well as peak velocity. We used a simple visually guided saccade paradigm to further characterize the profile of visually guided saccade metrics and dynamics in HFA and AD. It was found that children with HFA, but not AD, were more inaccurate across both small (5° and large (10° target amplitudes, and final eye position was hypometric at 10°. These findings suggest greater functional disturbance of the cerebellum in HFA than AD, and suggest fundamental difficulties with visual error monitoring in HFA.

  18. A CLOSER LOOK AT THE LkCa 15 PROTOPLANETARY DISK

    International Nuclear Information System (INIS)

    Andrews, Sean M.; Rosenfeld, Katherine A.; Wilner, David J.; Bremer, Michael

    2011-01-01

    We present 870 μm observations of dust continuum emission from the LkCa 15 protoplanetary disk at high angular resolution (with a characteristic scale of 0.''25 = 35 AU), obtained with the IRAM Plateau de Bure interferometer and supplemented by slightly lower resolution observations from the Submillimeter Array. We fit these data with simple morphological models to characterize the spectacular ring-like emission structure of this disk. Our analysis indicates that a small amount of 870 μm dust emission (∼5 mJy) originates inside a large (40-50 AU radius) low optical depth cavity. This result can be interpreted either in the context of an abrupt decrease by a factor of ∼5 in the radial distribution of millimeter-sized dust grains or as indirect evidence for a gap in the disk, in agreement with previous inferences from the unresolved infrared spectrum and scattered light images. A preliminary model focused on the latter possibility suggests the presence of a low-mass (planetary) companion, having properties commensurate with those inferred from the recent discovery of LkCa 15b.

  19. How to bring issues of health and safety closer to young workers during their work training

    Directory of Open Access Journals (Sweden)

    Helena Mesarič

    2016-06-01

    Full Text Available The data collected by the European Community indicates that the young, economically active population, aged from 18 to 24 years, is more likely to suffer from occupational injuries and occupational diseases in comparison with the rest of the working population, due to the lack of experience and knowledge about health and safety in the workplace, and insufficient training for safe and healthy work practices. Employers must establish an adequate system to ensure workplace health and safety, with an emphasis on providing safety training for pupils and students undergoing apprenticeship and the newly-employed young people. The Ministry of Labour, Family, Social Affairs and Equal Opportunities runs a series of projects aiming to promote health and safety culture among young people in Slovenia. The goal of the national programme for introducing occupational health and safety into the education process is offering a variety of tools and devices for educators and teachers, which can be employed to introduce the issues of occupational health and safety to young people in an exciting and engaging manner.

  20. Surgical interventions for meniscal tears: a closer look at the evidence

    NARCIS (Netherlands)

    Mutsaerts, Eduard L. A. R.; van Eck, Carola F.; van de Graaf, Victor A.; Doornberg, Job N.; van den Bekerom, Michel P. J.

    2016-01-01

    The aim of the present study was to compare the outcomes of various surgical treatments for meniscal injuries including (1) total and partial meniscectomy; (2) meniscectomy and meniscal repair; (3) meniscectomy and meniscal transplantation; (4) open and arthroscopic meniscectomy and (5) various

  1. Surgical interventions for meniscal tears: a closer look at the evidence.

    Science.gov (United States)

    Mutsaerts, Eduard L A R; van Eck, Carola F; van de Graaf, Victor A; Doornberg, Job N; van den Bekerom, Michel P J

    2016-03-01

    The aim of the present study was to compare the outcomes of various surgical treatments for meniscal injuries including (1) total and partial meniscectomy; (2) meniscectomy and meniscal repair; (3) meniscectomy and meniscal transplantation; (4) open and arthroscopic meniscectomy and (5) various different repair techniques. The Bone, Joint and Muscle Trauma Group Register, Cochrane Database, MEDLINE, EMBASE and CINAHL were searched for all (quasi) randomized controlled clinical trials comparing various surgical techniques for meniscal injuries. Primary outcomes of interest included patient-reported outcomes scores, return to pre-injury activity level, level of sports participation and persistence of pain using the visual analogue score. Where possible, data were pooled and a meta-analysis was performed. A total of nine studies were included, involving a combined 904 subjects, 330 patients underwent a meniscal repair, 402 meniscectomy and 160 a collagen meniscal implant. The only surgical treatments that were compared in homogeneous fashion across more than one study were the arrow and inside-out technique, which showed no difference for re-tear or complication rate. Strong evidence-based recommendations regarding the other surgical treatments that were compared could not be made. This meta-analysis illustrates the lack of level I evidence to guide the surgical management of meniscal tears. Level I meta-analysis.

  2. Is the Perspective of a Closer French Policy toward Russian a threat for Eastern European Countries?

    Directory of Open Access Journals (Sweden)

    Karim BELGACEM

    2016-12-01

    Full Text Available The current world is not moving as all specialists predicted. Brexit, Trump, everyone was wrong. This paper will have two targets: describing the French policy toward Russia, making a perspective on the future policy, whatever the new French presidency in 2017, Francois Hollande will transmit the key to his successor with new election. He refused to compete for a second mandate. It is good to remind that Hollande was involving in the Ukrainian affairs and had managed with Germany the Minsk I and II agreements. He also had suspended Mistral ships selling and approving sanctions against Russia. How will be the future with François Fillon, Marine Le Pen or other? The analysis will be focusing on the future relationships toward Russia and Eastern European Countries.

  3. A Closer look on Ineffectiveness in Riau Mainland Expenditure: Local Government Budget Case

    Science.gov (United States)

    Yandra, Alexsander; Roserdevi Nasution, Sri; Harsini; Wardi, Jeni

    2018-05-01

    this study discussed about the issues on ineffectiveness of expenditure by one Indonesia local Government in Riau. This Provence were amounted Rp. 10.7 trillion through Local Government Budget (APBD) in 2015. According to data from Financial Management Board and Regions Assets (BPKAD) APBD Riau in 2015 stood at approximately 37.58% until October 2015,another data taken from the Ministry of Home Affairs, Riau regional budget, from January to December 2015, it shows the lowest in Indonesia which amounted to 59.6%. The percentage described the lacking implementation of the budget, this can be interpreted that Riau government is less optimal and irrelevant in spending the budget in 2015. Through a theoretical approach to government spending, the implementation of public policies showed the ineffectiveness of the budget that have implicated towards regional development. As regional budget is only the draft in achieving the targets. Budget management in 2015 by the provincial administration through the Local Government Unit (SKPD) shows unsynchronized between the Medium Term Development Plan with the work program from SKPD.

  4. Bringing cancer care closer to home: Mauritania opens first nuclear medicine centre

    International Nuclear Information System (INIS)

    Omar, Yusuf

    2015-01-01

    The opening of the Islamic Republic of Mauritania’s first ever nuclear medicine centre with IAEA support in late 2014 will lead to improved access to modern diagnostics and treatment, as well as lower costs. The new facility is part of the country’s National Oncology Centre, which opened in 2010, with support from the IAEA. The centres offer comprehensive services in diagnosing, treating and managing cancer and other diseases in Mauritania and the surrounding region.

  5. Come Closer to Feminism: Gratitude as Activist Encounter in Women's and Gender Studies 101

    Science.gov (United States)

    Hogan, Katie

    2014-01-01

    Many teachers of introductory women's and gender studies find themselves in the position of introducing bad news to an already hostile audience. To deal directly with this dilemma, author Katie Hogan has approached student resistance to women's and gender studies (WGST) with carefully constructed syllabi designed to encourage…

  6. Natural gas pricing reform in China: Getting closer to a market system?

    International Nuclear Information System (INIS)

    Paltsev, Sergey; Zhang, Danwei

    2015-01-01

    Recent policy in China targets an increase in the contribution of natural gas to the nation's energy supply. Historically, China's natural gas prices have been highly regulated with a goal to protect consumers. The old pricing regime failed to provide enough incentives for natural gas suppliers, which often resulted in natural gas shortage. A new gas pricing reform was tested in Guangdong and Guangxi provinces in 2011, and introduced nationwide in 2013. The reform is aimed at creating a more market-based pricing mechanism. We show that a substantial progress toward a better predictability and transparency of prices has been made. The prices are now more connected with the international fuel oil and liquid petroleum gas prices. The government's approach for a temporary two-tier pricing when some volumes are still traded at old prices reduced a potential opposition during the new regime implementation. Some limitations of the natural gas pricing remain as it created biased incentives for producers and favors large natural gas suppliers. The pricing reform at its current stage falls short of establishing a complete market mechanism driven by an interaction of supply and demand of natural gas in China. - Highlights: • China's reform of natural gas pricing is in effect nationwide from 2013. • Prices are now connected to international fuel oil and liquid petroleum gas prices. • The reform benefits domestic producers and importers of natural gas. • There are still price distortions between industrial and residential sector. • The reform needs to create a system where both supply and demand are considered.

  7. A closer look at Arctic ozone loss and polar stratospheric clouds

    Directory of Open Access Journals (Sweden)

    N. R. P. Harris

    2010-09-01

    Full Text Available The empirical relationship found between column-integrated Arctic ozone loss and the potential volume of polar stratospheric clouds inferred from meteorological analyses is recalculated in a self-consistent manner using the ERA Interim reanalyses. The relationship is found to hold at different altitudes as well as in the column. The use of a PSC formation threshold based on temperature dependent cold aerosol formation makes little difference to the original, empirical relationship. Analysis of the photochemistry leading to the ozone loss shows that activation is limited by the photolysis of nitric acid. This step produces nitrogen dioxide which is converted to chlorine nitrate which in turn reacts with hydrogen chloride on any polar stratospheric clouds to form active chlorine. The rate-limiting step is the photolysis of nitric acid: this occurs at the same rate every year and so the interannual variation in the ozone loss is caused by the extent and persistence of the polar stratospheric clouds. In early spring the ozone loss rate increases as the solar insolation increases the photolysis of the chlorine monoxide dimer in the near ultraviolet. However the length of the ozone loss period is determined by the photolysis of nitric acid which also occurs in the near ultraviolet. As a result of these compensating effects, the amount of the ozone loss is principally limited by the extent of original activation rather than its timing. In addition a number of factors, including the vertical changes in pressure and total inorganic chlorine as well as denitrification and renitrification, offset each other. As a result the extent of original activation is the most important factor influencing ozone loss. These results indicate that relatively simple parameterisations of Arctic ozone loss could be developed for use in coupled chemistry climate models.

  8. Getting Closer to the Action: Using the Virtual Enactment Method to Understand Burglary

    NARCIS (Netherlands)

    Meenaghan, Amy; Nee, Claire; Van Gelder, Jean Louis; Otte, Marco; Vernham, Zarah

    In this article we describe a new method, the Virtual Enactment Method (VEM), to enhance offender recall and motivation to disclose information by having burglars reflect on their experience while committing a crime in a simulated virtual environment. Participants, a sample of 61 incarcerated

  9. Getting closer to people: family planning provision by drug shops in Uganda

    Science.gov (United States)

    Akol, Angela; Chin-Quee, Dawn; Wamala-Mucheri, Patricia; Namwebya, Jane Harriet; Mercer, Sarah Jilani; Stanback, John

    2014-01-01

    ABSTRACT Background: Private-sector drug shops are often the first point of health care in sub-Saharan Africa. Training and supporting drug shop and pharmacy staff to provide a wide range of contraceptive methods and information is a promising high-impact practice for which more information is needed to fully document implementation experience and impact. Methods: Between September 2010 and March 2011, we trained 139 drug shop operators (DSOs) in 4 districts of Uganda to safely administer intramuscular DMPA (depot medroxyprogesterone acetate) contraceptive injections. In 2012, we approached 54 of these DSOs and interviewed a convenience sample of 585 of their family planning clients to assess clients' contraceptive use and perspectives on the quality of care and satisfaction with services. Finally, we compared service statistics from April to June 2011 from drug shops, community health workers (CHWs), and government clinics in 3 districts to determine the drug shop market share of family planning services. Results: Most drug shop family planning clients interviewed were women with low socioeconomic status. The large majority (89%) were continuing family planning users. DMPA was the preferred contraceptive. Almost half of the drug shop clients had switched from other providers, primarily from government health clinics, mostly as a result of more convenient locations, shorter waiting times, and fewer stock-outs in drug shops. All clients reported that the DSOs treated them respectfully, and 93% trusted the drug shop operator to maintain privacy. Three-quarters felt that drug shops offered affordable family planning services. Most of the DMPA clients (74%) were very satisfied with receiving their method from the drug shop and 98% intended to get the next injection from the drug shop. Between April and June 2011, clinics, CHWs, and drug shops in 3 districts delivered equivalent proportions of couple-years of protection, with drug shops leading marginally at 36%, followed by clinics (33%) and CHWs (31%). Conclusion: Drug shops can be a viable and convenient source of short-acting contraceptive methods, including DMPA, serving as a complement to government services. Family planning programs in Uganda and elsewhere should consider including drug shops in the network of community-based family planning providers. PMID:25611480

  10. Correlation between Grade Point Averages and Student Evaluation of Teaching Scores: Taking a Closer Look

    Science.gov (United States)

    Griffin, Tyler J.; Hilton, John, III.; Plummer, Kenneth; Barret, Devynne

    2014-01-01

    One of the most contentious potential sources of bias is whether instructors who give higher grades receive higher ratings from students. We examined the grade point averages (GPAs) and student ratings across 2073 general education religion courses at a large private university. A moderate correlation was found between GPAs and student evaluations…

  11. Sensitive periods in epigenetics: bringing us closer to complex behavioral phenotypes.

    Science.gov (United States)

    Nagy, Corina; Turecki, Gustavo

    2012-08-01

    Genetic studies have attempted to elucidate causal mechanisms for the development of complex disease, but genome-wide associations have been largely unsuccessful in establishing these links. As an alternative link between genes and disease, recent efforts have focused on mechanisms that alter the function of genes without altering the underlying DNA sequence. Known as epigenetic mechanisms, these include DNA methylation, chromatin conformational changes through histone modifications, ncRNAs and, most recently, 5-hydroxymethylcytosine. Although DNA methylation is involved in normal development, aging and gene regulation, altered methylation patterns have been associated with disease. It is generally believed that early life constitutes a period during which there is increased sensitivity to the regulatory effects of epigenetic mechanisms. The purpose of this review is to outline the contribution of epigenetic mechanisms to genomic function, particularly in the development of complex behavioral phenotypes, focusing on the sensitive periods.

  12. A closer look at RapidArc® radiosurgery plans using very small fields

    DEFF Research Database (Denmark)

    Fog, Lotte S; Rasmussen, Jens F B; Aznar, Marianne

    2011-01-01

    and subsequently RapidArc® and conventional plans for two targets (0.4 and 9.9 cm(3)) were investigated. Doses from static fields 1-4 MLC leaves (0.25-1.00 cm) wide, and larger fields with 1-4 MLC leaves closed in their centres, were measured using the portal dosimeter-based QA system EPIQA (v¿1.3) and gafchromic...... by Eclipse by as much as 53% (v¿8.6, 2.5 mm grid). Eclipse underestimated the dose downstream from a few MLC leaves closed in the centre of a large MLC field by as much as 30%. Eclipse consistently overestimated the width of the penumbra by about 100%. For the conventional plans, there was good agreement...... v 8.6, 2.5 mm grid spacing). EPIQA data indicated that the measured dose profiles were overmodulated compared to the calculated one. The use of small subfields, typically a few MLC leaves wide, or larger fields with one or a few MLC leaves closed in its centre can result in significant errors...

  13. Big Data, Big Questions: A Closer Look at the Yale–Classical Archives Corpus (c. 2015

    Directory of Open Access Journals (Sweden)

    Trevor deClerq

    2016-07-01

    Full Text Available This paper responds to the article by Christopher White and Ian Quinn, in which these authors introduce the Yale-Classical Archives Corpus (YCAC. I begin by making some general observations about the corpus, especially with regard to ramifications of the keyboard-performance origins of many pieces in the original MIDI collection. I then assess the accuracy of the scale-degree and local-key fields in the database, which were generated by the Bellman-Budge key-finding algorithm. I point out that some of the inaccuracies from the key-finding algorithm's output may influence the results we obtain from statistical studies of this corpus. I also offer an alternative analysis to the authors' finding that the ratio of V7 to V chords increases over time in common-practice music. Specifically, I conjecture that this finding may be the result of (or related to increasing instrumental resources over time. I close with some recommendations for future versions of the corpus, such as enabling end users to help repair transcription errors as well as offer ground truths for harmonic analyses and key area information.

  14. Single top quark t W + X production at the LHC a closer look

    CERN Document Server

    Belyaev, A.

    2001-01-01

    We have reexamined the tW+X single top-quark production process which is important at the LHC contrary to the Tevatron. The special attention was paid to the treatment of the 2->2[Wt] process and the part of it's next-to-leading correction: 2->3[Wtb] process. We show that 2->3[Wtb] process has to be correctly taken into account with a proper subtraction of the top pair contribution and that it has qualitatively different kinematical distributions from the 2->2[Wt] process. We present the total cross section of the tW+X production to be about 62 pb at QCD scale be taken as a top quark mass, suggest the method of combining Wt and Wtb processes with gauge invariant subtraction of the tt-bar part which allows to reproduce correct kinematical properties and perform a proper event simulation of the tW+X process in the whole kinematical region.

  15. A closer look at the quadruply lensed quasar PSOJ0147: spectroscopic redshifts and microlensing effect

    Science.gov (United States)

    Lee, Chien-Hsiu

    2018-04-01

    I present a timely spectroscopic follow-up of the newly discovered, quadruply lensed quasar PSOJ0147 from the Pan-STARRS 1 survey. The newly acquired optical spectra with GMOS onboard the Gemini North Telescope allow us to pin down the redshifts of both the foreground lensing galaxy and the background lensed quasar to be z = 0.572 and 2.341, providing a firm basis for cosmography with future high-cadence photometric monitoring. I also inspect difference spectra from two of the quasar images, revealing the microlensing effect. Long-term spectroscopic follow-ups will shed lights on the structure of the active galactic nucleus and its environment.

  16. Does wearable device bring distraction closer to drivers? Comparing smartphones and Google Glass.

    Science.gov (United States)

    He, Jibo; McCarley, Jason S; Crager, Kirsten; Jadliwala, Murtuza; Hua, Lesheng; Huang, Sheng

    2018-07-01

    Head-up and wearable displays, such as Google Glass™, are sometimes marketed as safe in-vehicle alternatives to phone-based displays, as they allow drivers to receive messages without eye-off-the-road glances. However, head-up displays can still compromise driver performance (e.g., He et al., 2015b), as the distracting effect of interacting with any device will depend on the user's multitasking strategies. The present experiment examined drivers' interaction with a head-down smartphone display and a wearable head-up display. Participants performed a simulated driving task while receiving and responding to text messages via smartphone or the head-mounted display (HMD) on the Google Glass™. Incoming messages were signaled by an auditory alert, and responses were made vocally. When using Google Glass, participants' responses were quicker than that of smartphone, and the time to engage in a task did not vary according to lane-keeping difficulty. Results suggest that a willingness to engage more readily in distracting tasks may offset the potential safety benefits of wearable devices. Copyright © 2018 Elsevier Ltd. All rights reserved.

  17. A Closer Look: Examining Teachers' Language Around UDL, Inclusive Classrooms, and Intellectual Disability.

    Science.gov (United States)

    Lowrey, K Alisa; Hollingshead, Aleksandra; Howery, Kathy

    2017-02-01

    The purpose of this study was to examine the language teachers used to discuss inclusion, Universal Design for Learning (UDL), and learners with intellectual disability (ID) in an effort to better understand how teachers describe the relationship between those three. Utilizing a secondary analysis procedure, interview transcripts from seven general education teachers were reanalyzed to identify language used by teachers to refer to inclusive educational settings, the implementation of UDL, and learners with intellectual disability. The identified themes were then juxtaposed against the UDL framework (principles, guidelines, and checkpoints) and the current literature related to UDL and inclusive education. We end with recommendations for future practice and research involving inclusive classrooms, UDL, and learners with ID.

  18. Stress and the multiple-role woman: taking a closer look at the "superwoman".

    Science.gov (United States)

    Sumra, Monika K; Schillaci, Michael A

    2015-01-01

    In the academic literature there is debate as to whether women who engage in multiple social roles experience more or less stress than women in fewer roles. For the present research we examined the relationship between levels of engagement in seven distinct roles and perceived stress and life satisfaction in a small non-random sample of women in North America (N = 308). We did not find a significant correlation between role engagement and perceived stress, though we did find a small but significant positive correlation between role engagement and life satisfaction. Similarly, in a subset of the participants (N = 31), there was not a significant relationship between the level of role engagement and physiological stress as measured by hair or urinary cortisol levels. We found a significant negative correlation between perceived stress and life satisfaction, and role satisfaction. The results from multiple regression models did not identify the level of role engagement as a significant predictor of either perceived stress or life satisfaction. Role satisfaction in addition to several life style variables such as the frequency of sex and exercise were identified as significant predictors of both outcome variables. We also examined the popularized notion of the "superwoman", which we defined as women who fell within the 4th quartile of role engagement, or those engaged in the wife/mother/worker/homemaker role combination. Based on popular discourses surrounding the superwoman we expected that superwomen would exhibit higher levels of perceived stress. Our results revealed that superwomen do not experience a significantly higher level of perceived stress than non-superwomen. The results of our study therefore suggest that multiple role engagement in women, even at a relatively high level as experienced by "superwomen", is not associated with significantly higher stress, or reduced life satisfaction.

  19. Care closer to home - what does it offer? [PhD abstract

    DEFF Research Database (Denmark)

    Overgaard, Charlotte

    2012-01-01

    The thesis represents an empirical study of safety and quality of maternity care in freestanding midwifery units in Denmark. It is publication-based and consists of a thesis overview and three peer-reviewed publications. A multidisciplinary and mixed-methods approach is applied and the work...

  20. Flexibility Versus Expertise: A Closer Look at the Employment of United States Air Force Imagery Analysts

    Science.gov (United States)

    2017-10-01

    for career broadening, and then back to still imagery or FMV as 13 a senior NCO. Along the way, they might gain experience on advanced sensors... advanced analytical skills. More in-depth research and analysis is required for still imagery products and those Airmen typically focus on one target...16 EVALUATION CRITERIA – CAREER MANAGEMENT

  1. Bringing science education in and out of school closer together - (Symposium SBBq Brazil

    Directory of Open Access Journals (Sweden)

    J. Dillon

    2013-05-01

    Full Text Available Throughout the world, and for many decades, science-rich cultural institutions, such as zoos, aquaria, museums, and others, have collaborated with schools to provide students, teachers and families with opportunities  to expand their experiences and understanding of science. Programmes include supplementary classroom experiences; integrated core academic curricula; student science learning communities located in afterschool, summer, and weekend programmes; teacher professional development opportunities and communities; and even district infrastructure efforts around issues such as standards and assessment development or teacher preparation. Throughout the world, thesecollaborations have allowed students, and also teachers, to explore, understand, and care about a wide range of natural settings, phenomena, and cultural and historical objects. They have helped students to notice, consider, and investigate relationships between human social behavior and environmental consequences. They have  provided contexts, materials, rationales, and support for students and teachers to engage deeply in scientific inquiry processes of learning. These experiences—with an array of real-life settings, plants, animals, professional science communities, objects, scientific instrumentation, and current research and data—have been shown to spark curiosity, generate questions, and lead to a depth of understanding andcommitment in ways that are often less possible when the same material is encountered in books or on screens. This paper draws on theoretical perspectives as well as practical examples, focusing on inquiry-based science education, to show that formal-informal collaborations fall within the core activities  of both schools and organisations working in informal contexts including museums, youth programmes, and libraries. The paper argues that what is needed are more intentional and strategic deployments of resources, leading to collaborations that build on the particular affordances and strengths of different institutional types to meet shared goals  of making science learning more accessible and compelling to young people in our communities.

  2. Moving Closer to EarthScope: A Major New Initiative for the Earth Sciences*

    Science.gov (United States)

    Simpson, D.; Blewitt, G.; Ekstrom, G.; Henyey, T.; Hickman, S.; Prescott, W.; Zoback, M.

    2002-12-01

    EarthScope is a scientific research and infrastructure initiative designed to provide a suite of new observational facilities to address fundamental questions about the evolution of continents and the processes responsible for earthquakes and volcanic eruptions. The integrated observing systems that will comprise EarthScope capitalize on recent developments in sensor technology and communications to provide Earth scientists with synoptic and high-resolution data derived from a variety of geophysical sensors. An array of 400 broadband seismometers will spend more than ten years crossing the contiguous 48 states and Alaska to image features that make up the internal structure of the continent and underlying mantle. Additional seismic and electromagnetic instrumentation will be available for high resolution imaging of geological targets of special interest. A network of continuously recording Global Positioning System (GPS) receivers and sensitive borehole strainmeters will be installed along the western U.S. plate boundary. These sensors will measure how western North America is deforming, what motions occur along faults, how earthquakes start, and how magma flows beneath active volcanoes. A four-kilometer deep observatory bored directly into the San Andreas fault will provide the first opportunity to observe directly the conditions under which earthquakes occur, to collect fault rocks and fluids for laboratory study, and to monitor continuously an active fault zone at depth. All data from the EarthScope facilities will be openly available in real-time to maximize participation from the scientific community and to provide on-going educational outreach to students and the public. EarthScope's sensors will revolutionize observational Earth science in terms of the quantity, quality and spatial extent of the data they provide. Turning these data into exciting scientific discovery will require new modes of experimentation and interdisciplinary cooperation from the Earth science community. A broad sector of the university research community has joined with federal agencies to stimulate the development of facility plans and move EarthScope forward as a coordinated national initiative. With strong prospects for funding next year, the time is right for bold new ideas on how to maximize the use of these powerful new resources in the Earth scientist's toolkit. * On behalf of the EarthScope Working Group

  3. Phenomenology of bouncing black holes in quantum gravity: a closer look

    International Nuclear Information System (INIS)

    Barrau, Aurélien; Bolliet, Boris; Weimer, Celine; Vidotto, Francesca

    2016-01-01

    It was recently shown that black holes could be bouncing stars as a consequence of quantum gravity. We investigate the astrophysical signals implied by this hypothesis, focusing on primordial black holes. We consider different possible bounce times and study the integrated diffuse emission

  4. Patterns of impact in the weatherization assistance program: A closer look

    Energy Technology Data Exchange (ETDEWEB)

    Berry, L.G.; Brown, M.A.

    1994-06-01

    In 1990, the US Department of Energy (DOE) initiated a nationwide evaluation of the Weatherization Program. The second phase of the Single-Family Study, which is the subject of this report, is part of this coordinated evaluation effort. In the first chapter the goals and overall design of the study are presented. Chapter 2 discussed methodology, the sample selection process, and data collection procedures. The following chapters (3, 4, and 5) compare the four sets of comparison groups. In Chapter 3, the results of extensive descriptions and measurements of dwelling characteristics, and of blower door, heating system efficiency, and carbon monoxide (CO) tests are compared for control, weatherized, and treated dwellings. In Chapter 4, characteristics of weatherized dwellings with especially high versus those with especially low energy savings are examined. Dwelling characteristic, the presence and amounts of specific weatherization measures, and occupant characteristics and behaviors are examined as factors that may explain variations in energy savings. Chapter 5 presents comparisons of pairs of higher- versus lower-savings agencies in each of several climate regions. These comparison examined differences in housing stocks, service delivery procedures, weatherization measures installed, and allocation of agency funds. The focus here is on the identification of more and less effective weatherization practices and of promising future directions for the Program. This report adds to the earlier one by comparing the practices of lower-savings agencies with those of the higher-saving ones. Chapter 6 compares occupant perceptions of comfort, health, safety, and energy affordability for the weatherized versus control group clients, for the high- versus low-saving dwellings, and the higher-versus lower-saving agencies. Chapter 7 summarizes this study`s findings and presents recommendations.

  5. A Closer Look at the Impact of Globalization on Science Education

    Science.gov (United States)

    Clothey, Rebecca; Mills, Michelle; Baumgarten, Jacqueline

    2010-01-01

    This paper provides a historical overview of globalisation in order to illustrate how globalisation both shapes and is shaped by external forces. The authors use this perspective to generate a dialogue about the science education project "The Case of Sustainability by the Bay", and raise some questions to further the discussion on the impact of…

  6. Plant identification credibility in ethnobotany: a closer look at Polish ethnographic studies

    Directory of Open Access Journals (Sweden)

    Łuczaj Łukasz J

    2010-12-01

    Full Text Available Abstract Background This paper is an attempt to estimate the percentage of erroneously identified taxa in ethnographic studies concerning the use of plants and to propose a code for recording credibility of identification in historical ethnobotany publications. Methods A sample of Polish-language ethnobotanical literature (45 published sources from 1874-2005 and four collections of voucher specimens (from 1894-1975 were analyzed. Errors were detected in the publications by comparing the data with existing knowledge on the distribution of plant names and species ranges. The voucher specimens were re-examined. A one-letter code was invented for quick identification of the credibility of data published in lists of species compiled from historical or ethnographic sources, according to the source of identification: voucher specimen, Latin binominal, botanical expert, obvious widespread name, folk name, mode of use, range, physical description or photograph. To test the use of the code an up-to-date list of wild food plants used in Poland was made. Results A significant difference between the ratio of mistakes in the voucher specimen collections and the ratio of detectable mistakes in the studies without herbarium documentation was found. At least 2.3% of taxa in the publications were identified erroneously (mean rate was 6.2% per publication, and in half of these mistakes even the genus was not correct. As many as 10.0% of voucher specimens (on average 9.2% per collection were originally erroneously identified, but three quarters of the identification mistakes remained within-genus. The species of the genera Thymus, Rumex and Rubus were most often confused within the genus. Not all of the invented credibility codes were used in the list of wild food plants, but they may be useful for other researchers. The most often used codes were the ones signifying identification by: voucher specimen, botanical expert and by a common name used throughout the country. Conclusions The results of this study support the rigorous use of voucher specimens in ethnobotany, although they also reveal a relatively high percentage of misidentified taxa in the specimens studied. The invented credibility coding system may become a useful tool for communication between historical ethnobotanists, particularly in creating larger databases.

  7. AP Report to the Nation: A Closer Look at the Nation and Florida

    Science.gov (United States)

    Sawtell, Ellen A.; Gillie, Jacqueline M.; Smith, Patricia Z.

    2012-01-01

    In February 2012, the College Board published The 8th Annual AP Report to the Nation. This session provides a deeper dive into key information for the United States with an emphasis on Florida, and participants hear how one school in Florida utilizes AP Potential™ to help build their AP Program. Participants also learn about AP participation and…

  8. A closer look on the polyhydroxybutyrate- (PHB-) negative phenotype of Ralstonia eutropha PHB-4.

    Science.gov (United States)

    Raberg, Matthias; Voigt, Birgit; Hecker, Michael; Steinbüchel, Alexander

    2014-01-01

    The undefined poly(3-hydroxybutyrate)- (PHB-) negative mutant R. eutropha PHB-4 was generated in 1970 by 1-nitroso-3-nitro-1-methylguanidine (NMG) treatment. Although being scientific relevant, its genotype remained unknown since its isolation except a recent first investigation. In this study, the mutation causing the PHA-negative phenotype of R. eutropha PHB-4 was confirmed independently: sequence analysis of the phaCAB operon identified a G320A mutation in phaC yielding a stop codon, leading to a massively truncated PhaC protein of 106 amino acids (AS) in R. eutropha PHB-4 instead of 589 AS in the wild type. No other mutations were observed within the phaCAB operon. As further mutations probably occurred in the genome of mutant PHB-4 potentially causing secondary effects on the cells' metabolism, the main focus of the study was to perform a 2D PAGE-based proteome analysis in order to identify differences in the proteomes of the wild type and mutant PHB-4. A total of 20 differentially expressed proteins were identified which provide valuable insights in the metabolomic changes of mutant PHB-4. Besides excretion of pyruvate, mutant PHB-4 encounters the accumulation of intermediates such as pyruvate and acetyl-CoA by enhanced expression of the observed protein species: (i) ThiJ supports biosynthesis of cofactor TPP and thereby reinforces the 2-oxoacid dehydrogenase complexes as PDHC, ADHC and OGDHC in order to convert pyruvate at a higher rate and the (ii) 3-isopropylmalate dehydrogenase LeuB3 apparently directs pyruvate to synthesis of several amino acids. Different (iii) acylCoA-transferases enable transfer reactions between organic acid intermediates, and (iv) citrate lyase CitE4 regenerates oxaloacetate from citrate for conversion with acetyl-CoA in the TCC in an anaplerotic reaction. Substantial amounts of reduction equivalents generated in the TCC are countered by (v) synthesis of more ubiquinones due to enhanced synthesis of MenG2 and MenG3, thereby improving the respiratory chain which accepts electrons from NADH and succinate.

  9. Patient Outcomes as Transformative Mechanisms to Bring Health Information Technology Industry and Research Informatics Closer Together.

    Science.gov (United States)

    Krive, Jacob

    2015-01-01

    Despite the fast pace of recent innovation within the health information technology and research informatics domains, there remains a large gap between research and academia, while interest in translating research innovations into implementations in the patient care settings is lacking. This is due to absence of common outcomes and performance measurement targets, with health information technology industry employing financial and operational measures and academia focusing on patient outcome concerns. The paper introduces methodology for and roadmap to introduction of common objectives as a way to encourage better collaboration between industry and academia using patient outcomes as a composite measure of demonstrated success from health information systems investments. Along the way, the concept of economics of health informatics, or "infonomics," is introduced to define a new way of mapping future technology investments in accordance with projected clinical impact.

  10. 'A closer look upon whiplash, postconcussion syndrome and posttraumatic headache. Differences and similarities'

    DEFF Research Database (Denmark)

    Kasch, Helge

    2017-01-01

    Summary Post-whiplash, -concussion and -traumatic headache are all well-known entities described after accidents. Over the years they gave rise to discussion about the cause, treatment and consequences. Over the years the frequency of each of these diagnoses has varied. But are they really three...

  11. The structure of executive functions in children: A closer examination of inhibition, shifting, and updating

    NARCIS (Netherlands)

    van der Ven, S.H.G.; Kroesbergen, E.H.; Boom, J.; Leseman, P.P.M.

    2013-01-01

    An increasing number of studies has investigated the latent factor structure of executive functions. Some studies found a three-factor structure of inhibition, shifting, and updating, but others could not replicate this finding. We assumed that the task choices and scoring methods might be

  12. The structure of executive functions in children: a closer examination of inhibition, shifting, and updating.

    Science.gov (United States)

    van der Ven, Sanne H G; Kroesbergen, Evelyn H; Boom, Jan; Leseman, Paul P M

    2013-03-01

    An increasing number of studies has investigated the latent factor structure of executive functions. Some studies found a three-factor structure of inhibition, shifting, and updating, but others could not replicate this finding. We assumed that the task choices and scoring methods might be responsible for these contradictory findings. Therefore, we selected tasks in which input modality was varied, controlled for baseline speed, and used both speed and accuracy scores, in order to investigate whether a three factor model with inhibition, shifting, and updating could still be replicated. In a group of 211 children, who were tested at the beginning of grade 1, at approximately 6 years of age, and again after 18 months, the best fitting model was not the three-factor model, but instead consisted of an updating factor and a combined inhibition and shifting factor, besides two baseline speed factors (verbal and motor). We argue that these results might indicate that the structural organization of executive functions might be different in children than in adults, but that there might also be an alternative explanation: the distinction in executive functions might not accurately represent cognitive structures but instead be a methodological artefact. © 2012 The British Psychological Society.

  13. Look closer: Time sequence photography of Roosters Comb in the Sheep Creek Range, Nevada

    Science.gov (United States)

    The importance of understanding natural landscape changes is key in properly determining rangeland ecology. Time sequence photography allows a snapshot of a landscape to be documented and enables the ability to compare natural changes overtime. Photographs of Roosters Comb were taken from the same v...

  14. A Closer Look at Eduardo M. Torner's Bibliographic Survey of Spain's Traditional Music and Dance

    Directory of Open Access Journals (Sweden)

    J. Katz, Israel

    2004-12-01

    Full Text Available Eduardo M. Torner (1881-1955 was among the most notable pioneers who contributed to the nascent field of ethnomusicology in Spain. His early field researches in Asturias and Galicia yielded exemplary publications and his associates included such outstanding figures as Ramón Menéndez Pidal, Manuel Manrique de Lara, Jesús Bal y Gay, and Kurt Schindler. The two bibliographies contained in this article, which Torner included among the essays in his classic Temas folklóricos: Música y Poesía (Madrid, 1935, represent but a mere sampling of the 4,000 entries he is purported to have gathered concering Spain's tradidonal music and dance. Fleeing first to Valencia and then to Barcelona at the outbreak of the Civil War, he utlimately sought refuge in London, where he continued his researches until his death. During the transitional period from Valencia to England, he lost his precious collection of photographs, historical documents, and personal manuscripts, together with his massive bibliographical compilation. Here I have reordered the bibliographies from Temas folklóricos, insuring that all his entries are accurate and complete, adding personal comments to Tomer's observations, and providing four indices: 1 Abbreviations and publications surveyed; 2 Authors; 3 Geographic locales, and 4 Subject matter.

    Eduardo M. Torner (1881-1935 fue uno de los más notables pioneros que contribuyeron al surgimiento de la etnomusicología en España. Sus primeras investigaciones de campo en Asturias y Galicia produjeron publicaciones modélicas, y se relacionó por su trabajo con figuras tan eminentes como Ramón Menéndez Pidal, Manuel Manrique de Lara, Jesús Bal y Gay y Kurt Schindler. Las dos bibliografías contenidas en este artículo que Torner incluyó entre los ensayos de su trabajo clásico Temas folklóricos: Música y Poesía (Madrid, 1935, no representan sino una mera muestra de las 4.000 entradas que se cree que recogió relativas a la música tradicional y danzas de España. Huyendo primeramente a Valencia y después a Barcelona al comienzo de la Guerra Civil, buscó por último refugio en Londres, donde continuó sus investigaciones hasta su fallecimiento. Durante el período de traslado de Valencia a Inglaterra, extravió su preciosa colección de fotografías, documentos históricos y manuscritos personales, junto con su enorme compilación de fichas bibliográficas. En este artículo he reordenado las bibliografías contenidas en Temas folklóricos, asegurándome de que todas sus citas sean exactas y completas, he añadido comentarios personales a las observaciones de Torner, y he elaborado también los siguientes índices: 1 Abreviaciones, incluyendo las publicaciones utilizadas; 2 Onomástico; 3 Toponímico; y 4 Materias.

  15. A closer look at the history and genetics of Tourette syndrome

    OpenAIRE

    Díaz-Anzaldúa, Adriana; Rouleau, Guy A.

    2008-01-01

    Tourette syndrome (TS) was named after Georges Albert Edouard Brutus Gilles de la Tourette, who made its first formal description at the end of the 19th century. Nevertheless, some evidence indicates the disorder may have been recognised at least two thousand years ago. Tic like behaviours were recorded by Aretaeus of Cappadocia and several centuries later by Sprenger and Kraemer, followed by other descriptions. The English writer Samuel Johnson, author of the first English Language Dictionar...

  16. Preventive and therapeutic challenges in combating Zika virus infection: are we getting any closer?

    Science.gov (United States)

    Singh, Meera V; Weber, Emily A; Singh, Vir B; Stirpe, Nicole E; Maggirwar, Sanjay B

    2017-06-01

    The neuroteratogenic nature of Zika Virus (ZIKV) infection has converted what would have been a tropical disease into a global threat. Zika is transmitted vertically via infected placental cells especially in the first and second trimesters. In the developing central nervous system (CNS), ZIKV can infect and induce apoptosis of neural progenitor cells subsequently causing microcephaly as well as other neuronal complications in infants. Its ability to infect multiple cell types (placental, dermal, and neural) and increased environmental stability as compared to other flaviviruses (FVs) has broadened the transmission routes for ZIKV infection from vector-mediated to transmitted via body fluids. To further complicate the matters, it is genetically similar (about 40%) with the four serotypes of dengue virus (DENV), so much so that it can almost be called a fifth DENV serotype. This homology poses the risk of causing cross-reactive immune responses and subsequent antibody-dependent enhancement (ADE) of infection in case of secondary infections or for immunized individuals. All of these factors complicate the development of a single preventive vaccine candidate or a pharmacological intervention that will completely eliminate or cure ZIKV infection. We discuss all of these factors in detail in this review and conclude that a combinatorial approach including immunization and treatment might prove to be the winning strategy.

  17. Gated communities and urban sustainability: taking a closer look at the future

    CSIR Research Space (South Africa)

    Landman, K

    2000-08-01

    Full Text Available residents and to be detrimental to long-term urban sustainability and political stability. It could just be that the very measure that is implemented to address crime and instability after a while becomes a major source of conflict20. • Urban... impact on the quality of life in an area and on building a liveable and vibrant city. It could also lead to the formation of political pressure groups and attempts to pressurise the local government into making certain decisions. It could not only...

  18. A Closer Look at Dark Toxicity of the Photosensitizer TMPyP in Bacteria.

    Science.gov (United States)

    Eckl, Daniel B; Dengler, Linda; Nemmert, Marina; Eichner, Anja; Bäumler, Wolfgang; Huber, Harald

    2018-01-01

    Photodynamic inactivation of bacteria (PIB) is based on photosensitizers which absorb light and generate reactive oxygen species (ROS), killing cells via oxidation. PIB is evaluated by comparing viability with and without irradiation, where reduction of viability in the presence of the photosensitizer without irradiation is considered as dark toxicity. This effect is controversially discussed for photosensitizers like TMPyP (5,10,15,20-Tetrakis(1-methyl-4-pyridinio)porphyrin tetra(p-toluensulfonate). TMPyP shows a high absorption coefficient for blue light and a high yield of ROS production, especially singlet oxygen. Escherichia coli and Bacillus atrophaeus were incubated with TMPyP and irradiated with different light sources at low radiant exposures (μW per cm²), reflecting laboratory conditions of dark toxicity evaluation. Inactivation of E. coli occurs for blue light, while no effect was detectable for wavelengths >450 nm. Being more susceptible toward PIB, growth of B. atrophaeus is even reduced for light with emission >450 nm. Decreasing the light intensities to nW per cm² for B. atrophaeus, application of TMPyP still caused bacterial killing. Toxic effects of TMPyP disappeared after addition of histidine, quenching residual ROS. Our experiments demonstrate that the evaluation of dark toxicity of a powerful photosensitizer like TMPyP requires low light intensities and if necessary additional application of substances quenching any residual ROS. © 2017 The American Society of Photobiology.

  19. Tiny cells meet big questions: a closer look at bacterial cell biology

    OpenAIRE

    Goley, Erin D.

    2013-01-01

    While studying actin assembly as a graduate student with Matt Welch at the University of California at Berkeley, my interest was piqued by reports of surprising observations in bacteria: the identification of numerous cytoskeletal proteins, actin homologues fulfilling spindle-like functions, and even the presence of membrane-bound organelles. Curiosity about these phenomena drew me to Lucy Shapiro's lab at Stanford University for my postdoctoral research. In the Shapiro lab, and now in my lab...

  20. Misplaying the Angles: A Closer Look at the Illinois Tuition Tax Credit Law.

    Science.gov (United States)

    Pathak, Arohi; Wessely, Mike; Mincberg, Elliot

    In 1999, Illinois enacted its tuition tax credit law, which offers tax credits to taxpayers whose own children are attending school, as opposed to tax credits to businesses and/or individuals who contribute to tuition scholarship programs. Recent data suggest that the Illinois tax credit program is benefiting middle- and upper-class families more…