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Sample records for warm ischaemia-reperfusion injury

  1. Isoprostanes--markers of ischaemia reperfusion injury.

    LENUS (Irish Health Repository)

    Sakamoto, H

    2012-02-03

    Ischaemia reperfusion injury is a common and important phenomenon that occurs predictably in patients undergoing such procedures as cardiopulmonary bypass, thrombolysis, surgery under tourniquet, organ transplantation or embolectomy. Oxidative stress and the resulting lipid peroxidation play a major role in reperfusion injury. Membrane and cellular dysfunction result and, subsequently, organ injury or failure may ensue. Traditional methods of quantifying ischaemia reperfusion injury, including measurement of malondialdehyde, lack specificity and sensitivity. It was reported in 1990 that isoprostanes, a series of prostaglandin-like compounds, are produced by the free radical-catalyzed peroxidation of arachidonic acid. Measurement of the isoprostane concentration in urine or plasma provides the most reliable, non-invasive method currently available to assess oxidative stress in vivo. Serial measurement of isoprostanes in biological fluids has enhanced our understanding of the mechanisms underlying ischaemia reperfusion injury itself and its role in certain diseases. Furthermore, measurement of the isoprostane concentration provides a means to assess the effects of prophylactic and therapeutic interventions. In the future, the development of rapid, simple assays for isoprostanes offers the potential to assess prognosis during and after ischaemia reperfusion events.

  2. Intestinal Ischaemia-Reperfusion Injury and Semen Characteristics ...

    African Journals Online (AJOL)

    olayemitoyin

    Nigeria. Summary: Increasing production of goats takes their reproductive ... of testicular damage and infertility and is a form of ischaemia-reperfusion injury. ... concentration, percentage of normal sperm cells, abnormal sperm cells and ...

  3. Short communication:Intestinal Ischaemia-Reperfusion Injury and ...

    African Journals Online (AJOL)

    This study investigates the effect of intestinal ischaemia-reperfusion (IIR) injury on semen characteristics in WAD bucks. Six healthy adult male ... Many of the abnormalities involved midpiece and tail abnormalities which are very vital to propulsion and may cause an inability of the sperm cells to fertilize. This hitherto silent ...

  4. Honey improves spermatogenesis and hormone secretion in testicular ischaemia-reperfusion-induced injury in rats.

    Science.gov (United States)

    Gholami, M; Abbaszadeh, A; Khanipour Khayat, Z; Anbari, K; Baharvand, P; Gharravi, A M

    2018-02-01

    This study was conducted to survey the protective effect of pre-treatment with Persian honey during post-ischaemia reperfusion on ischaemia-reperfusion (IR)-induced testis injury. Animals were divided into four groups of IR, honey + ischaemia- reperfusion (HIR), vitamin C + ischaemia- reperfusion (VIR) and carbohydrates + ischaemia- reperfusion (CIR). The testes were examined for spermatogenesis index. Detection of single- and double-stranded DNA breaks at the early stages of apoptosis was performed. Total serum concentration of FSH, LH and testosterone was measured using ELISA. All data were expressed as mean ± SD in each group, and significance was set at p ≤ .05. Spermatogenesis index was significant in the HIR group (p honey decreases the cellular damage and apoptosis during testicular I/R injury, with significant protective effects on reproductive hormone production. © 2017 Blackwell Verlag GmbH.

  5. Ischaemia-reperfusion injury: a major protagonist in kidney transplantation.

    Science.gov (United States)

    Ponticelli, Claudio

    2014-06-01

    Ischaemia-reperfusion injury (IRI) is a frequent event in kidney transplantation, particularly when the kidney comes from a deceased donor. The brain death is usually associated with generalized ischaemia due to a hyperactivity of the sympathetic system. In spite of this, most donors have profound hypotension and require administration of vasoconstrictor agents. Warm ischaemia after kidney vessels clamping and the cold ischaemia after refrigeration also reduce oxygen and nutrients supply to tissues. The reperfusion further aggravates the state of oxidation and inflammation created by ischaemia. IRI first attacks endothelial cells and tubular epithelial cells. The lesions may be so severe that they lead to acute kidney injury (AKI) and delayed graft function (DGF), which can impair the graft survival. The unfavourable impact of DGF is worse when DGF is associated with acute rejection. Another consequence of IRI is the activation of the innate immunity. Danger signals released by dying cells alarm Toll-like receptors that, through adapter molecules and a chain of kinases, transmit the signal to transcription factors which encode the genes regulating inflammatory cells and mediators. In the inflammatory environment, dendritic cells (DCs) intercept the antigen, migrate to lymph nodes and present the antigen to immunocompetent cells, so activating the adaptive immunity and favouring rejection. Attempts to prevent IRI include optimal management of donor and recipient. Calcium-channel blockers, l-arginine and N-acetylcysteine could obtain a small reduction in the incidence of post-transplant DGF. Fenoldopam, Atrial Natriuretic Peptide, Brain Natriuretic Peptide and Dopamine proved to be helpful in reducing the risk of AKI in experimental models, but there is no controlled evidence that these agents may be of benefit in preventing DGF in kidney transplant recipients. Other antioxidants have been successfully used in experimental models of AKI but only a few studies of poor

  6. Stem cells and their role in renal ischaemia reperfusion injury.

    Science.gov (United States)

    Bagul, Atul; Frost, Jodie H; Drage, Martin

    2013-01-01

    Ischaemia-reperfusion injury (IRI) remains one of the leading causes of acute kidney injury (AKI). IRI is an underlying multifactorial pathophysiological process which affects the outcome in both native and transplanted patients. The high morbidity and mortality associated with IRI/AKI and disappointing results from current available clinical therapeutic approaches prompt further research. Stem cells (SC) are undifferentiated cells that can undergo both renewal and differentiation into one or more cell types which can possibly ameliorate IRI. To carry out a detailed literature analysis and construct a comprehensive literature review addressing the role of SC in AKI secondary to IRI. Evidence favouring the role of SC in renal IRI and evidence showing no benefits of SC in renal IRI are the two main aspects to be studied. The search strategy was based on an extensive search addressing MESH terms and free text terms. The majority of studies in the field of renal IRI and stem cell therapy show substantial benefits. Studies were mostly conducted in small animal models, thus underscoring the need for further pre-clinical studies in larger animal models, and results should be taken with caution. SC therapy may be promising though controversy exists in the exact mechanism. Thorough scientific exploration is required to assess mechanism, safety profile, reproducibility and methods to monitor administered SC. Copyright © 2012 S. Karger AG, Basel.

  7. Protective effects of Rosmarinic acid against renal ischaemia/reperfusion injury in rats

    International Nuclear Information System (INIS)

    Ozturk, H.; Ozturk, H.; Terzi, E.H.

    2014-01-01

    Objective: To investigate the potential protective effects of Rosmarinic acid (RA) on rats exposed to ischaemia/reperfusion renal injury. Methods: The prospective study was conducted at Abant Izzet Baysal University, Turkey, and comprised 21 male Spraque Dawley rats weighing 250-270g each. They were divided into three equal groups. Unilaterally nephrectomised rats were subjected to 60 minutes of left renal ischaemia followed by 60 minutes of reperfusion. Group 1 had shamoperated animals; group 2 had ischaemia/reperfusion untreated animals; and group 3 had ischaemia/reperfusion animals treated with rosmarinic acid. Serum creatinine, blood urea nitrogen, tissue malondialdehyde, glutathione peroxidase, superoxide dismutase and myeloperoxidase (MPO) activities, and light microscopic findings were evaluated. SPSS 17 was used for statistical analysis. Results: Treatment of rats with rosmarinic acid produced a reduction in the serum levels of creatinine and blood urea nitrogen compared to the other groups. However, no statistically significant difference was found. The levels of malondialdehyde and myeloperoxidase were decreased in the renal tissue of group 3, while glutathione peroxidose and superoxide dismutase levels remained unchanged. The injury score decreased in the treatment group rats compared to the untreated group. Rosmarinic acid significantly decreased focal glomerular necrosis, dilatation of Bowman's capsule, degeneration of tubular epithelium, necrosis in tubular epithelium, and tubular dilatation. Conclusions: Rosmarinic acid prevented ischaemia/reperfusion injury in the kidneys by decreasing oxidative stress. (author)

  8. Activated protein C attenuates acute ischaemia reperfusion injury in skeletal muscle.

    LENUS (Irish Health Repository)

    Dillon, J P

    2012-02-03

    Activated protein C (APC) is an endogenous anti-coagulant with anti-inflammatory properties. The purpose of the present study was to evaluate the effects of activated protein C in the setting of skeletal muscle ischaemia reperfusion injury (IRI). IRI was induced in rats by applying rubber bands above the levels of the greater trochanters bilaterally for a period of 2h followed by 12h reperfusion. Treatment groups received either equal volumes of normal saline or activated protein C prior to tourniquet release. Following 12h reperfusion, muscle function was assessed electrophysiologically by electrical field stimulation. The animals were then sacrificed and skeletal muscle harvested for evaluation. Activated protein C significantly attenuated skeletal muscle reperfusion injury as shown by reduced myeloperoxidase content, wet to dry ratio and electrical properties of skeletal muscle. Further in vitro work was carried out on neutrophils isolated from healthy volunteers to determine the direct effect of APC on neutrophil function. The effects of APC on TNF-alpha stimulated neutrophils were examined by measuring CD18 expression as well as reactive oxygen species generation. The in vitro work demonstrated a reduction in CD18 expression and reactive oxygen species generation. We conclude that activated protein C may have a protective role in the setting of skeletal muscle ischaemia reperfusion injury and that this is in part mediated by a direct inhibitory effect on neutrophil activation.

  9. Protective effect of Mangifera indica L. extract (Vimang) on the injury associated with hepatic ischaemia reperfusion.

    Science.gov (United States)

    Sánchez, Gregorio Martínez; Rodríguez H, María A; Giuliani, Attilia; Núñez Sellés, Alberto J; Rodríguez, Niurka Pons; León Fernández, Olga Sonia; Re, L

    2003-03-01

    The effect of Mangifera indica L. extract (Vimang) on treatment of injury associated with hepatic ischaemia/reperfusion was tested. Vimang protects from the oxidative damage induced by oxygen-based free radicals as shown in several in vitro test systems conducted. The ability of Vimang to reduce liver damage was investigated in rats undergoing right-lobe blood fl ow occlusion for 45 min followed by 45 min of reperfusion. The ischaemia/reperfusion model leads to an increase of transaminase (ALT and AST), membrane lipid peroxidation, tissue neutrophil in filtration, DNA fragmentation, loss of protein -SH groups, cytosolic Ca2+ overload and a decrease of catalase activity. Oral administration of Vimang (50, 110 and 250 mg/kg, b.w.) 7 days before reperfusion, reduced transaminase levels and DNA fragmentation in a dose dependent manner (p Vimang also restored the cytosolic Ca2+ levels and inhibited polymorphonuclear migration at a dose of 250 mg/kg b.w., improved the oxidation of total and non protein sulfhydryl groups and prevented modification in catalase activity, uric acid and lipid peroxidation markers (p Vimang could be a useful new natural drug for preventing oxidative damage during hepatic injury associated with free radical generation. Copyright 2003 John Wiley & Sons, Ltd.

  10. Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemia-reperfusion injury in heart

    NARCIS (Netherlands)

    Nederlof, Rianne; Eerbeek, Otto; Hollmann, Markus W.; Southworth, Richard; Zuurbier, Coert J.

    2014-01-01

    Mitochondrially bound hexokinase II (mtHKII) has long been known to confer cancer cells with their resilience against cell death. More recently, mtHKII has emerged as a powerful protector against cardiac cell death. mtHKII protects against ischaemia-reperfusion (IR) injury in skeletal muscle and

  11. Effects of Human Umbilical Cord Mesenchymal Stem Cells on Renal Ischaemia-reperfusion Injury in Rats

    Directory of Open Access Journals (Sweden)

    Zhenyu Qiu

    2014-08-01

    Full Text Available Objective This study aims to observe the function of umbilical cord-mesenchymal stem cells (UC-MSCs labelled with enhanced green fluorescent protein (eGFP in the repair of renal ischaemia-reperfusion (I/R injury, to determine the effects on inflammatory cascade in an established rat model and to explore possible pathogenesis. Materials and Methods Sixty rats were randomly divided into three groups: the sham-operated, I/R and UC-MSC treatment groups. All rats underwent right nephrectomy. Ischaemia was induced in the left kidney by occlusion of the renal artery and vein for 1hour, followed by reperfusion for 24 hours or 48 hours. Kidney samples were collected to observe morphological changes. Immunohistochemistry was performed to assess the expression of intercellular adhesion molecule 1 (ICAM-1 in the renal tissue sample, as well as the number of infiltrating polymorphonuclear neutrophils (PMNLs and UC-MSCs with positive eGFP. Results Renal histopathological damages and the expression of ICAM-1 and PMNL increased significantly in the I/R group compared with those in the sham-operated group, whereas the damages were less conspicuous in the UC-MSC treatment group. Conclusions Renal ICAM-1, which mediated PMNL infiltration and contributed to renal damage, was significantly up-regulated in the I/R group. UC-MSCs were identified to inhibit these pathological processes and protect the kidney from I/R injury.

  12. Protective effects of dexrazoxane against acute ischaemia/reperfusion injury of rat hearts

    Czech Academy of Sciences Publication Activity Database

    Neckář, Jan; Boudíková, Adéla; Mandíková, Petra; Štěrba, M.; Popelová, O.; Mikšík, Ivan; Dabrowská, L.; Mráz, J.; Geršl, V.; Kolář, František

    2012-01-01

    Roč. 90, č. 9 (2012), s. 1303-1310 ISSN 0008-4212 R&D Projects: GA AV ČR(CZ) IAAX01110901; GA ČR(CZ) GA305/09/0416 Institutional research plan: CEZ:AV0Z50110509 Keywords : heart * dexrazoxane * ischaemia * reperfusion * infarct size * arrhythmias * cardioprotection * reactive oxygen species Subject RIV: FR - Pharmacology ; Medidal Chemistry Impact factor: 1.556, year: 2012

  13. Mild episodes of tourniquet-induced forearm ischaemia-reperfusion injury results in leukocyte activation and changes in inflammatory and coagulation markers

    Directory of Open Access Journals (Sweden)

    Bastawrous Salah S

    2007-05-01

    Full Text Available Abstract Background Monocytes and neutrophils are examples of phagocytic leukocytes, with neutrophils being considered as the 'chief' phagocytic leukocyte. Both monocytes and neutrophils have been implicated to play a key role in the development of ischaemia-reperfusion injury, where they are intrinsically involved in leukocyte-endothelial cell interactions. In this pilot study we hypothesised that mild episodes of tourniquet induced forearm ischaemia-reperfusion injury results in leukocyte activation and changes in inflammatory and coagulation markers. Methods Ten healthy human volunteers were recruited after informed consent. None had any history of cardiovascular disease with each subject volunteer participating in the study for a 24 hour period. Six venous blood samples were collected from each subject volunteer at baseline, 10 minutes ischaemia, 5, 15, 30, 60 minutes and 24 hours reperfusion, by means of a cannula from the ante-cubital fossa. Monocyte and neutrophil leukocyte sub-populations were isolated by density gradient centrifugation techniques. Leukocyte trapping was investigated by measuring the concentration of leukocytes in venous blood leaving the arm. The cell surface expression of CD62L (L-selectin, CD11b and the intracellular production of hydrogen peroxide (H2O2 were measured via flow cytometry. C-reactive protein (CRP was measured using a clinical chemistry analyser. Plasma concentrations of D-dimer and von Willebrand factor (vWF were measured using enzyme-linked fluorescent assays (ELFA. Results During ischaemia-reperfusion injury, there was a decrease in CD62L and an increase in CD11b cell surface expression for both monocytes and neutrophils, with changes in the measured parameters reaching statistical significance (p =2O2 production by leukocyte sub-populations, which was measured as a marker of leukocyte activation. Intracellular production of H2O2 in monocytes during ischaemia-reperfusion injury reached statistical

  14. Tourniquet-induced ischaemia-reperfusion injury: the comparison of antioxidative effects of small-dose propofol and ketamine

    Directory of Open Access Journals (Sweden)

    Karaca Omer

    Full Text Available Abstract Objectives: The aim of the present study was to investigate the preventive effects of propofol and ketamine as small dose sedation during spinal anaesthesia on tourniquet-induced ischaemia-reperfusion injury. Methods: 30 patients were randomly assigned into two groups of 15 patients. In the propofol group, sedation was performed with propofol 0.2 mg·kg-1 followed by infusion at a rate of 2 mg·kg-1·h-1. In the ketamine group, a continuous infusion of ketamine 0.5 mg·kg-1·h-1 was used until the end of surgery. Intravenous administration of midazolam was not used in any patients. Ramsay sedation scale was used for assessing the sedation level. Venous blood samples were obtained before propofol and ketamine infusion (T1, at 30 minutes (min of tourniquet ischaemia (T2, and 5 min after tourniquet deflation (T3 for malondialdehyde (MDA measurements. Results: No differences were noted between the groups in haemodynamic (p > 0.05 and demographic data (p > 0.05. There was no statistically significant difference between the two groups in terms of T1, T2 and T3 periods (p > 0.05. There was a statistically increase observed in MDA values respectively both in Group P and Group K between the reperfusion period (1.95 ± 0.59, 2.31 ± 0.48 and pre-ischaemia (1.41 ± 0.38, 1.54 ± 0.45, and ischaemia (1.76 ± 0.70, 1.71 ± 0.38 (µmoL-1 periods (p < 0.05. Conclusions: Small-dose propofol and ketamine has similar potential to reduce the oxidative stress caused by tourniquet-induced ischaemia-reperfusion injury in patients undergoing arthroscopic knee surgery under spinal anaesthesia.

  15. Hydroxychloroquine Protects against Cardiac Ischaemia/Reperfusion Injury In Vivo via Enhancement of ERK1/2 Phosphorylation.

    Directory of Open Access Journals (Sweden)

    Lauren Bourke

    Full Text Available An increasing number of investigations including human studies demonstrate that pharmacological ischaemic preconditioning is a viable way to protect the heart from myocardial ischaemia/reperfusion (I/R injury. This study investigated the role of hydroxychloroquine (HCQ in the heart during I/R injury. In vitro and in vivo models of myocardial I/R injury were used to assess the effects of HCQ. It was found that HCQ was protective in neonatal rat cardiomyocytes through inhibition of apoptosis, measured by TUNEL and cleaved caspase-3. This protection in vitro was mediated through enhancement of ERK1/2 phosphorylation mediated by HCQ in a dose-dependent fashion. A decrease in infarct size was observed in an in vivo model of myocardial I/R injury in HCQ treated animals and furthermore this protection was blocked in the presence of the ERK1/2 inhibitor U0126. For the first time, we have shown that HCQ promotes a preconditioning like protection in an in vivo simulated rat myocardial I/R injury model. Moreover, it was shown that HCQ is protective via enhanced phosphorylation of the pro-survival kinase ERK1/2.

  16. Bilirubin provides perforator flap protection from ischaemia-reperfusion injury in a rat model: a preliminary result.

    Science.gov (United States)

    Kim, Sung Young; Rah, Dong Kyun; Chong, Yosep; Lee, Song Hyun; Park, Tae Hwan

    2016-10-01

    The use of bilirubin, a well-known and powerful antioxidant, has gained popularity in recent years because of its role in the prevention of ischaemic heart disease in patients with Gilbert's syndrome. We investigate the effects of bilirubin on ischaemia-reperfusion (I/R) injury using a rat perforator flap model. Forty-eight rats were randomly divided into two groups: experimental (bilirubin) group (n = 24) and control group (n = 24). In each group, elevated bilateral deep inferior epigastric perforator (DIEP) flaps were created. The right (no ischaemia side) and left (ischaemia side) DIEP flaps were separated according to the presence of ischaemia induction. Ischaemia was induced in anaesthetised rats by perforator clamping for 15 or 30 minutes. After surgery, the flap survival was assessed daily on postoperative days 0 to 5, and overall histological changes of DIEP flaps above the perforator were analysed at postoperative day 5. The flap survival rate in the bilirubin group was significantly higher than that in the control group at the ischaemia side following perforator clamping for 15 or 30 minutes (93·42 ± 4·48% versus 89·63 ± 3·98%, P = 0·002; and 83·96 ± 4·23% versus 36·46 ± 6·38%, P bilirubin was found to alleviate perforator flap necrosis caused by I/R injury in this experimental rat model. © 2015 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

  17. Involvement of protein kinase B and mitogen-activated protein kinases in experimental normothermic liver ischaemia-reperfusion injury.

    Science.gov (United States)

    Cursio, R; Filippa, N; Miele, C; Van Obberghen, E; Gugenheim, J

    2006-06-01

    This study evaluated the role of protein kinase B (PKB), phosphatidylinositol 3-kinase (PI3-K), Bcl-2-associated death protein (BAD) and mitogen-activated protein kinases (MAPKs) in normothermic ischaemia-reperfusion (IR)-induced apoptosis in rat liver. Rats were divided into two groups that received either phosphate-buffered saline (control) or the caspase inhibitor Z-Asp-2,6-dichorobenzoyloxymethylketone (Z-Asp-cmk), injected intravenously 2 min before the induction of 120 min of normothermic liver ischaemia. Liver apoptosis was assessed by the terminal deoxyribonucleotidyltransferase-mediated dUTP nick end labelling (TUNEL) method. PI3-K, PKB, BAD and MAPK activities were measured in ischaemic and non-ischaemic lobes at various times after reperfusion. The number of TUNEL-positive cells was significantly decreased after pretreatment with Z-Asp-cmk. In controls, PI3-K and PKB activities and BAD phosphorylation were inhibited in ischaemic liver lobes. The MAPKs (extracellular signal-regulated kinases, c-Jun N-terminal kinase and p38) showed different patterns of activation during IR. PKB activity was not modified by pretreatment with Z-Asp-cmk. Induction of apoptosis during IR liver injury might be triggered by inactivation of the antiapoptotic PI3-K-PKB pathway and activation of the proapoptotic MAPKs. Copyright (c) 2006 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

  18. Preserved cardiac mitochondrial function and reduced ischaemia/reperfusion injury afforded by chronic continuous hypoxia: Role of opioid receptors

    Czech Academy of Sciences Publication Activity Database

    Maslov, L. N.; Naryzhnaya, N. V.; Prokudina, E. S.; Kolář, František; Gorbunov, A. S.; Zhang, Y.; Wang, H.; Tsibulnikov, S.Yu.; Portnichenko, A. G.; Lasukova, T. V.; Lishmanov, Yu. B.

    2015-01-01

    Roč. 42, č. 5 (2015), s. 496-501 ISSN 1440-1681 R&D Projects: GA ČR(CZ) GAP303/12/1162 Institutional support: RVO:67985823 Keywords : cardioprotection * chronic hypoxia * ischaemia/reperfusion * mitochondrial function * opioid receptors Subject RIV: ED - Physiology Impact factor: 2.004, year: 2015

  19. Protective effect of hydroalcoholic extract of Andrographis paniculata on ischaemia-reperfusion induced myocardial injury in rats.

    Science.gov (United States)

    Ojha, Shreesh Kumar; Bharti, Saurabh; Joshi, Sujata; Kumari, Santosh; Arya, Dharamvir Singh

    2012-03-01

    Protecting myocardium from ischaemia-reperfusion (I-R) injury is important to reduce the complication of myocardial infarction (MI) and interventional revascularization procedures. In the present study, the cardioprotective potential of hydroalcoholic extract of Andrographis paniculata was evaluated against left anterior descending coronary artery (LADCA) ligation-induced I-R injury of myocardium in rats. MI was induced in rats by LADCA ligation for 45 min followed by reperfusion for 60 min. The rats were divided into five experimental groups viz., sham (saline treated, but LADCA was not ligated), I-R control (saline treated + I-R), benazepril (30 mg/kg + I-R), A. paniculata (200 mg/kg per se) and A. paniculata (200 mg/kg + I-R). A. paniculata was administered orally for 31 days. On day 31, rats were subjected to the I-R and cardiac function parameters were recorded. Further, rats were sacrificed and heart was excised for biochemical and histopathological studies. In I-R control group, LADCA ligation resulted in significant cardiac dysfunction evidenced by reduced haemodynamic parameters; mean arterial pressure (MAP) and heart rate (HR). The left ventricular contractile function was also altered. In I-R control group, I-R caused decline in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH) as well as leakage of myocytes injury marker enzymes, creatine phosphokinase-MB (CK-MB) isoenzyme and lactate dehydrogenase (LDH), and enhanced lipid peroxidation product, malonaldialdehyde (MDA). However, rats pretreated with A. paniculata 200 mg/kg showed favourable modulation of haemodynamic and left ventricular contractile function parameters, restoration of the myocardial antioxidants and prevention of depletion of myocytes injury marker enzymes along with inhibition of lipid peroxidation. Histopathological observations confirmed the protective effects of A. paniculata. The cardioprotective effects of A. paniculata were

  20. Protective agents used as additives in University of Wisconsin solution to promote protection against ischaemia-reperfusion injury in rat lung.

    Science.gov (United States)

    Chiang, C H; Wu, K; Yu, C P; Perng, W C; Yan, H C; Wu, C P; Chang, D M; Hsu, K

    1998-09-01

    1. An intervention to reduce ischaemia-reperfusion lung injury will be an important advance in transplant medicine. Although the mechanisms associated with producing ischaemia-reperfusion endothelial injury have not been completely elucidated, many of the injury mediators have been studied in detail. While no single pharmacological therapy is likely to be totally effective in eliminating this complex injury, we have developed a mixture of agents that are known to block pathways involved in producing ischaemia-reperfusion-associated lung vascular injury.2. The present study modified University of Wisconsin solution (UW) by adding one of the protective agents prostaglandin E1 (PGE1), dexamethasone (Dex) or dibutyryl cAMP (Bt2-cAMP), or a combination of these, to the perfusate of rat lungs exposed to 4 h of cold ischaemia followed by 1 h of reperfusion. Nine modified UW solutions were studied: (1) UW+Dex, (2) UW+PGE1, (3) UW+Bt2-cAMP, (4) UW+Dexx3, (5) UW+PGE1x3, (6) UW+Bt2-cAMPx3, (7) UW+Dex+PGE1, (8) UW+Dex+Bt2-cAMP, (9) UW+PGE1+Bt2-cAMP. These solutions were utilized in individual experiments to assess haemodynamic changes, lung weight gain, the capillary filtration coefficient (Kfc) and pathology in all lungs.3. The results indicate that lung weight gain and Kfc values were significantly lower than with UW alone in groups 1, 2 and 3, which contained only one additional protective agent. In groups 4, 5 and 6, which contain three times the concentration of each protective agent, both Kfc and lung weight gain were similar to those measured in groups 1, 2 and 3, i.e. lungs were protected but the protection was not dose dependent. In groups 7, 8 and 9, which contained two protective agents, lung weight gain and Kfc were greatly reduced compared with UW alone. Histopathological studies showed similar decreases in the injury profiles of lungs.4. Although UW contains several antioxidant protective agents such as allopurinol and glutathione, it did not provide effective

  1. Depletion of kidney CD11c+ F4/80+ cells impairs the recovery process in ischaemia/reperfusion-induced acute kidney injury.

    Science.gov (United States)

    Kim, Myung-Gyu; Boo, Chang Su; Ko, Yoon Sook; Lee, Hee Young; Cho, Won Yong; Kim, Hyoung Kyu; Jo, Sang-Kyung

    2010-09-01

    Recent studies provided evidence of the potential role of CD11c(+) F4/80(+) dendritic subset in mediating injury and repair. The purpose of this study was to examine the role of kidney CD11c(+) F4/80(+) dendritic subset in the recovery phase of ischaemia/reperfusion injury (IRI). Following ischaemia/reperfusion (I/R), liposome clodronate or phosphate buffered saline (PBS) was administered, and on day 7 biochemical and histologic kidney damage was assessed. Activation and depletion of CD11c(+) F4/80(+) dendritic subset were confirmed by flow cytometry. Isolation of kidney CD11c(+) cells on days 1 and 7 with in vitro culture for measuring cytokines was performed to define functional characteristics of these cells, and adoptive transfer of CD11c(+) cells was also done. Following kidney IRI, the percentage of CD11c(+) F4/80(+) kidney dendritic cell subset that co-expresses maturation marker increased. Liposome clodronate injection after I/R resulted in preferential depletion of CD11c(+) F4/80(+) kidney dendritic subset, and depletion of these cells was associated with persistent kidney injury, more apoptosis, inflammation and impaired tubular cell proliferation. CD11c(+) F4/80(+) cell depletion was also associated with higher tissue levels of pro-inflammatory cytokines and lower level of IL-10, indicating the persistence of inflammatory milieu. Isolated kidney CD11c(+) cells on day 7 showed different phenotype with increased production of IL-10 compared with those on day 1. Adoptive transfer of CD11c(+) cells partially reversed impaired tissue recovery. Our results suggest that kidney CD11c(+) F4/80(+) dendritic subset might contribute to the recovery process by dynamic phenotypic change from pro-inflammatory to anti-inflammatory with modulation of immune response.

  2. Protective Effect of Creatine Elevation against Ischaemia Reperfusion Injury Is Retained in the Presence of Co-Morbidities and during Cardioplegia.

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    Hannah J Whittington

    Full Text Available Ischaemic heart disease is most prevalent in the ageing population and often exists with other comorbidities; however the majority of laboratory research uses young, healthy animal models. Several recent workshops and focus meetings have highlighted the importance of using clinically relevant models to help aid translation to realistic patient populations. We have previously shown that mice over-expressing the creatine transporter (CrT-OE have elevated intracellular creatine levels and are protected against ischaemia-reperfusion injury. Here we test whether elevating intracellular creatine levels retains a cardioprotective effect in the presence of common comorbidities and whether it is additive to protection afforded by hypothermic cardioplegia.CrT-OE mice and wild-type controls were subjected to transverse aortic constriction for two weeks to induce compensated left ventricular hypertrophy (LVH. Hearts were retrogradely perfused in Langendorff mode for 15 minutes, followed by 20 minutes ischaemia and 30 minutes reperfusion. CrT-OE hearts exhibited significantly improved functional recovery (Rate pressure product during reperfusion compared to WT littermates (76% of baseline vs. 59%, respectively, P = 0.02. Aged CrT-OE mouse hearts (78±5 weeks also had enhanced recovery following 15 minutes ischaemia (104% of baseline vs. 67%, P = 0.0007. The cardioprotective effect of hypothermic high K+ cardioplegic arrest, as used during cardiac surgery and donor heart transplant, was further enhanced in prolonged ischaemia (90 minutes in CrT-OE Langendorff perfused mouse hearts (76% of baseline vs. 55% of baseline as seen in WT hearts, P = 0.02.These observations in clinically relevant models further support the development of modulators of intracellular creatine content as a translatable strategy for cardiac protection against ischaemia-reperfusion injury.

  3. Amelioration of renal ischaemia-reperfusion injury by liposomal delivery of curcumin to renal tubular epithelial and antigen-presenting cells.

    Science.gov (United States)

    Rogers, N M; Stephenson, M D; Kitching, A R; Horowitz, J D; Coates, P T H

    2012-05-01

    Renal ischaemia-reperfusion (IR) injury is an inevitable consequence of renal transplantation, causing significant graft injury, increasing the risk of rejection and contributing to poor long-term graft outcome. Renal injury is mediated by cytokine and chemokine synthesis, inflammation and oxidative stress resulting from activation of the NF-κB pathway. We utilized liposomal incorporation of a potent inhibitor of the NF-κB pathway, curcumin, to target delivery to renal tubular epithelial and antigen-presenting cells. Liposomes containing curcumin were administered before bilateral renal ischaemia in C57/B6 mice, with subsequent reperfusion. Renal function was assessed from plasma levels of urea and creatinine, 4 and 24 h after reperfusion. Renal tissue was examined for NF-κB activity and oxidative stress (histology, immunostaining) and for apoptosis (TUNEL). Cytokines and chemokines were measured by RT-PCR and Western blotting. Liposomal curcumin significantly improved serum creatinine, reduced histological injury and cellular apoptosis and lowered Toll-like receptor-4, heat shock protein-70 and TNF-α mRNA expression. Liposomal curcumin also reduced neutrophil infiltration and diminished inflammatory chemokine expression. Curcumin liposomes reduced intracellular superoxide generation and increased superoxide dismutase levels, decreased inducible NOS mRNA expression and 3-nitrotyrosine staining consistent with limitations in nitrosative stress and inhibited renal tubular mRNA and protein expression of thioredoxin-interacting protein. These actions of curcumin were mediated by inhibition of NF-κB, MAPK and phospho-S6 ribosomal protein. Liposomal delivery of curcumin promoted effective, targeted delivery of this non-toxic compound that provided cytoprotection via anti-inflammatory and multiple antioxidant mechanisms following renal IR injury. © 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.

  4. Crocin prevents retinal ischaemia/reperfusion injury-induced apoptosis in retinal ganglion cells through the PI3K/AKT signalling pathway.

    Science.gov (United States)

    Qi, Yun; Chen, Li; Zhang, Lei; Liu, Wen-Bo; Chen, Xiao-Yan; Yang, Xin-Guang

    2013-02-01

    Crocin is a pharmacologically active component of Crocus sativus L. (saffron) and has been reported to be useful in the treatment of neuronal damage. In the present study, we investigated the neuroprotective effect of crocin on retinal ganglion cells (RGCs) after retinal ischaemia/reperfusion (IR) injury, and our results show that crocin acts through the PI3K/AKT signalling pathway. Retinal IR injury was induced by raising the intraocular pressure of Sprague-Dawley rats to 110 mmHg for 60 min. The neuroprotective effect of crocin was determined by quantifying the surviving RGCs and apoptotic RGCs following IR injury by means of retrograde labelling and TUNEL staining, respectively. The phosphorylated AKT protein level was determined by western blot and immunohistochemical analysis. To determine the extent to which the PI3K/AKT pathway contributes to the neuroprotective effect of crocin, experiments were also performed using the PI3K inhibitor LY294002. Compared with the IR + vehicle group, crocin (50 mg/kg) treatment enhanced RGC survival by approximately 36% and decreased RGC apoptosis by 44% after retinal IR injury. Western blot and immunohistochemical analysis demonstrated that the PI3K/AKT pathway was activated by crocin in the ganglion cell layer after retinal IR injury. Intravitreal injection of LY294002 blocked the neuroprotective effect of crocin on IR-induced RGC death. In conclusion, crocin prevents retinal IR-induced apoptosis of RGCs by activating the PI3K/AKT signalling pathway. Copyright © 2012 Elsevier Ltd. All rights reserved.

  5. Growth hormone-releasing hormone promotes survival of cardiac myocytes in vitro and protects against ischaemia-reperfusion injury in rat heart.

    Science.gov (United States)

    Granata, Riccarda; Trovato, Letizia; Gallo, Maria Pia; Destefanis, Silvia; Settanni, Fabio; Scarlatti, Francesca; Brero, Alessia; Ramella, Roberta; Volante, Marco; Isgaard, Jorgen; Levi, Renzo; Papotti, Mauro; Alloatti, Giuseppe; Ghigo, Ezio

    2009-07-15

    The hypothalamic neuropeptide growth hormone-releasing hormone (GHRH) stimulates GH synthesis and release in the pituitary. GHRH also exerts proliferative effects in extrapituitary cells, whereas GHRH antagonists have been shown to suppress cancer cell proliferation. We investigated GHRH effects on cardiac myocyte cell survival and the underlying signalling mechanisms. Reverse transcriptase-polymerase chain reaction analysis showed GHRH receptor (GHRH-R) mRNA in adult rat ventricular myocytes (ARVMs) and in rat heart H9c2 cells. In ARVMs, GHRH prevented cell death and caspase-3 activation induced by serum starvation and by the beta-adrenergic receptor agonist isoproterenol. The GHRH-R antagonist JV-1-36 abolished GHRH survival action under both experimental conditions. GHRH-induced cardiac cell protection required extracellular signal-regulated kinase (ERK)1/2 and phosphoinositide-3 kinase (PI3K)/Akt activation and adenylyl cyclase/cAMP/protein kinase A signalling. Isoproterenol strongly upregulated the mRNA and protein of the pro-apoptotic inducible cAMP early repressor, whereas GHRH completely blocked this effect. Similar to ARVMs, in H9c2 cardiac cells, GHRH inhibited serum starvation- and isoproterenol-induced cell death and apoptosis through the same signalling pathways. Finally, GHRH improved left ventricular recovery during reperfusion and reduced infarct size in Langendorff-perfused rat hearts, subjected to ischaemia-reperfusion (I/R) injury. These effects involved PI3K/Akt signalling and were inhibited by JV-1-36. Our findings suggest that GHRH promotes cardiac myocyte survival through multiple signalling mechanisms and protects against I/R injury in isolated rat heart, indicating a novel cardioprotective role of this hormone.

  6. Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion.

    Science.gov (United States)

    Whittington, Hannah J; Ostrowski, Philip J; McAndrew, Debra J; Cao, Fang; Shaw, Andrew; Eykyn, Thomas R; Lake, Hannah; Tyler, Jack; Schneider, Jurgen E; Neubauer, Stefan; Zervou, Sevasti; Lygate, Craig A

    2018-03-02

    Mitochondrial creatine kinase (MtCK) couples ATP production via oxidative phosphorylation to phosphocreatine in the cytosol, which acts as a mobile energy store available for regeneration of ATP at times of high demand. We hypothesised that elevating MtCK would be beneficial in ischaemia-reperfusion (I/R) injury. Mice were created overexpressing the sarcomeric MtCK gene with αMHC promoter at the Rosa26 locus (MtCK-OE) and compared with wild-type (WT) littermates. MtCK activity was 27% higher than WT, with no change in other CK isoenzymes or creatine levels. Electron microscopy confirmed normal mitochondrial cell density and mitochondrial localisation of transgenic protein. Respiration in isolated mitochondria was unaltered and metabolomic analysis by 1H-NMR suggests that cellular metabolism was not grossly affected by transgene expression. There were no significant differences in cardiac structure or function under baseline conditions by cine-MRI or LV haemodynamics. In Langendorff-perfused hearts subjected to 20min ischaemia and 30 min reperfusion, MtCK-OE exhibited less ischaemic contracture and improved functional recovery (Rate pressure product 58% above WT; P < 0.001). These hearts had reduced myocardial infarct size, which was confirmed in vivo: 55±4% in WT vs 29±4% in MtCK-OE; P < 0.0001). Isolated cardiomyocytes from MtCK-OE hearts exhibited delayed opening of the mitochondrial permeability transition pore (mPTP) compared to WT, which was confirmed by reduced mitochondrial swelling in response to calcium. There was no detectable change in the structural integrity of the mitochondrial membrane. Modest elevation of MtCK activity in the heart does not adversely affect cellular metabolism, mitochondrial or in vivo cardiac function, but modifies mPTP opening to protect against I/R injury and improve functional recovery. Our findings support MtCK as a prime therapeutic target in myocardial ischaemia.

  7. Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor

    Science.gov (United States)

    Gobbetti, T; Ducheix, S; le Faouder, P; Perez, T; Riols, F; Boue, J; Bertrand-Michel, J; Dubourdeau, M; Guillou, H; Perretti, M; Vergnolle, N; Cenac, N

    2015-01-01

    Background and Purpose Long-term intake of dietary fatty acids is known to predispose to chronic inflammation, but their effects on acute intestinal ischaemia/reperfusion (I/R) injury is unknown. The aim of this study was to determine the consequences of a diet rich in n-3 or n-6 polyunsaturated fatty acids (PUFA) on intestinal I/R-induced damage. Experimental Approach Mice were fed three different isocaloric diets: a balanced diet used as a control and two different PUFA-enriched diets, providing either high levels of n-3 or of n-6 PUFA. Intestinal injury was evaluated after intestinal I/R. PUFA metabolites were quantitated in intestinal tissues by LC-MS/MS. Key Results In control diet-fed mice, intestinal I/R caused inflammation and increased COX and lipoxygenase-derived metabolites compared with sham-operated animals. Lipoxin A4 (LxA4) was significantly and selectively increased after ischaemia. Animals fed a high n-3 diet did not display a different inflammatory profile following intestinal I/R compared with control diet-fed animals. In contrast, intestinal inflammation was decreased in the I/R group fed with high n-6 diet and level of LxA4 was increased post-ischaemia compared with control diet-fed mice. Blockade of the LxA4 receptor (Fpr2), prevented the anti-inflammatory effects associated with the n-6 rich diet. Conclusions and Implications This study indicates that high levels of dietary n-6, but not n-3, PUFAs provides significant protection against intestinal I/R-induced damage and demonstrates that the endogenous production of LxA4 can be influenced by diet. PMID:25296998

  8. Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor.

    Science.gov (United States)

    Gobbetti, T; Ducheix, S; le Faouder, P; Perez, T; Riols, F; Boue, J; Bertrand-Michel, J; Dubourdeau, M; Guillou, H; Perretti, M; Vergnolle, N; Cenac, N

    2015-02-01

    Long-term intake of dietary fatty acids is known to predispose to chronic inflammation, but their effects on acute intestinal ischaemia/reperfusion (I/R) injury is unknown. The aim of this study was to determine the consequences of a diet rich in n-3 or n-6 polyunsaturated fatty acids (PUFA) on intestinal I/R-induced damage. Mice were fed three different isocaloric diets: a balanced diet used as a control and two different PUFA-enriched diets, providing either high levels of n-3 or of n-6 PUFA. Intestinal injury was evaluated after intestinal I/R. PUFA metabolites were quantitated in intestinal tissues by LC-MS/MS. In control diet-fed mice, intestinal I/R caused inflammation and increased COX and lipoxygenase-derived metabolites compared with sham-operated animals. Lipoxin A4 (LxA4 ) was significantly and selectively increased after ischaemia. Animals fed a high n-3 diet did not display a different inflammatory profile following intestinal I/R compared with control diet-fed animals. In contrast, intestinal inflammation was decreased in the I/R group fed with high n-6 diet and level of LxA4 was increased post-ischaemia compared with control diet-fed mice. Blockade of the LxA4 receptor (Fpr2), prevented the anti-inflammatory effects associated with the n-6 rich diet. This study indicates that high levels of dietary n-6, but not n-3, PUFAs provides significant protection against intestinal I/R-induced damage and demonstrates that the endogenous production of LxA4 can be influenced by diet. © 2014 The British Pharmacological Society.

  9. Transcriptional responses in the adaptation to ischaemia-reperfusion injury: a study of the effect of ischaemic preconditioning in total knee arthroplasty patients

    Directory of Open Access Journals (Sweden)

    Doran Peter P

    2010-05-01

    Full Text Available Abstract Background Ischaemic preconditioning (IPC has emerged as a method of reducing ischaemia-reperfusion injury. However, the complex mechanism through which IPC elicits this protection is not fully understood. The aim of this study was to investigate the genomic response induced by IPC in muscle biopsies taken from the operative leg of total knee arthroplasty patients in order to gain insight into the IPC mechanism. Methods Twenty patients, undergoing primary total knee arthroplasty, were randomly assigned to IPC (n = 10 and control (n = 10 groups. Patients in the IPC group received ischaemic preconditioning immediately prior to surgery. IPC was induced by three five-minute cycles of tourniquet insufflation interrupted by five-minute cycles of reperfusion. A muscle biopsy was taken from the operative knee of control and IPC-treated patients at the onset of surgery and, again, at one hour into surgery. The gene expression profile of muscle biopsies was determined using the Affymetrix Human U113 2.0 microarray system and validated using real-time polymerase chain reaction (RT-PCR. Measurements of C-reactive protein (CRP, erythrocyte sedimentation (ESR, white cell count (WCC, cytokines and haemoglobin were also made pre- and post-operatively. Results Microarray analysis revealed a significant increase in the expression of important oxidative stress defence genes, immediate early response genes and mitochondrial genes. Upregulation of pro-survival genes was also observed and correlated with a downregulation of pro-apoptotic gene expression. CRP, ESR, WCC, cytokine and haemoglobin levels were not significantly different between control and IPC patients. Conclusions The findings of this study suggest that IPC of the lower limb in total knee arthroplasty patients induces a protective genomic response, which results in increased expression of immediate early response genes, oxidative stress defence genes and pro-survival genes. These findings

  10. Transcriptional responses in the adaptation to ischaemia-reperfusion injury: a study of the effect of ischaemic preconditioning in total knee arthroplasty patients

    LENUS (Irish Health Repository)

    Murphy, Terence

    2010-05-10

    Abstract Background Ischaemic preconditioning (IPC) has emerged as a method of reducing ischaemia-reperfusion injury. However, the complex mechanism through which IPC elicits this protection is not fully understood. The aim of this study was to investigate the genomic response induced by IPC in muscle biopsies taken from the operative leg of total knee arthroplasty patients in order to gain insight into the IPC mechanism. Methods Twenty patients, undergoing primary total knee arthroplasty, were randomly assigned to IPC (n = 10) and control (n = 10) groups. Patients in the IPC group received ischaemic preconditioning immediately prior to surgery. IPC was induced by three five-minute cycles of tourniquet insufflation interrupted by five-minute cycles of reperfusion. A muscle biopsy was taken from the operative knee of control and IPC-treated patients at the onset of surgery and, again, at one hour into surgery. The gene expression profile of muscle biopsies was determined using the Affymetrix Human U113 2.0 microarray system and validated using real-time polymerase chain reaction (RT-PCR). Measurements of C-reactive protein (CRP), erythrocyte sedimentation (ESR), white cell count (WCC), cytokines and haemoglobin were also made pre- and post-operatively. Results Microarray analysis revealed a significant increase in the expression of important oxidative stress defence genes, immediate early response genes and mitochondrial genes. Upregulation of pro-survival genes was also observed and correlated with a downregulation of pro-apoptotic gene expression. CRP, ESR, WCC, cytokine and haemoglobin levels were not significantly different between control and IPC patients. Conclusions The findings of this study suggest that IPC of the lower limb in total knee arthroplasty patients induces a protective genomic response, which results in increased expression of immediate early response genes, oxidative stress defence genes and pro-survival genes. These findings indicate that

  11. Aerosolized PGE1, PGI2 and nitroprusside protect against vascular leakage in lung ischaemia-reperfusion.

    Science.gov (United States)

    Schütte, H; Löckinger, A; Seeger, W; Grimminger, F

    2001-07-01

    High permeability oedema is an important feature in lung injury secondary to ischaemia-reperfusion. This study investigated the influence of aerosolized prostaglandin E1 (PGE1), prostaglandin I2 (PCI2) and the nitric oxide (NO)-donor, sodium nitroprusside (SNP) on microvascular barrier function in pulmonary ischaemia-reperfusion. Buffer-perfused rabbit lungs were exposed to 180 or 210 min of warm ischaemia while maintaining anoxic ventilation and a positive intravascular pressure. Reperfusion provoked a transient, mostly precapillary elevation of vascular resistance, followed by a severe increase of the capillary filtration coefficient (Kfc) versus nonischaemic controls (3.17+/-0.34 versus 0.85+/-0.05 cm3 x s(-1) cmH2O(-1) x g(-1) x 10(-4) after 30 min of reperfusion), and progressive oedema formation. Short-term aerosolization of SNP, PGE1 or PGI2 at the beginning of ischaemia largely suppressed the Kfc increase (1.36+/-0.22, 1.32+/-0.23 and 1.32+/-0.22 cm3 x s(-1) x cmH2O(-1) x g(-1) x 10(-4), respectively) and oedema formation. In contrast, application prior to reperfusion was much less effective, with some reduction of Kfc increase by PGI2 and SNP and no effect of PGE, (1.79+/-0.31, 2.2+/-0.53 and 3.2+/-0.05 cm3 x s(-1) x cmH2O(-1) x g(-1) x 10(-4), respectively). Haemodynamics, including microvascular pressure, were only marginally affected by the chosen doses of aerosolized vasodilators. It is concluded that short-term aerosolization of prostaglandin E1, prostaglandin I2 and sodium nitroprusside at the onset of ischaemia is highly effective in maintaining endothelial barrier properties in pulmonary ischaemia-reperfusion. This effect is apparently attributable to nonvasodilatory mechanisms exerted by these agents. Alveolar deposition of prostaglandins and/or nitric oxide donors by the aerosol technique may offer pulmonary protection in ischaemia-reperfusion injury.

  12. Estudo da fração inspirada de oxigênio na isquemia-reperfusão pulmonar em ratos Study of ventilation with different inspired oxygen concentration on lung ischaemia-reperfusion injury in rats

    Directory of Open Access Journals (Sweden)

    Rafael José Silveira

    2004-10-01

    Full Text Available OBJETIVO: Estudar o efeito das frações inspiradas de oxigênio (FiO2 a 0,21, 0,40 e 1,00 na isquemia-reperfusão pulmonar. MÉTODOS: Foram utilizados 40 ratos Wistar, distribuídos aleatoriamente em quatro grupos. O grupo I foi o controle e, nos grupos II, III e IV, os animais foram ventilados durante a isquemia-reperfusão com FiO2 a 0,21, 0,40 e 1,00 respectivamente. O modelo utilizado foi de isquemia-reperfusão normotérmica, in situ. O tempo de isquemia foi de 30 minutos e o de reperfusão, de 10 minutos. Como parâmetros de avaliação, utilizou-se a pressão arterial média sistêmica (PAM, a relação entre a pressão parcial de oxigênio e a fração inspirada de oxigênio (PO2/FiO2, a dosagem da glutationa reduzida (GSH e das substâncias reativas ao ácido tiobarbitúrico (TBARS no tecido pulmonar e a relação entre o peso pulmonar úmido e o peso pulmonar seco. RESULTADOS: Os resultados mostraram que a ventilação com FiO2 a 0,21, quando comparada à ventilação com FiO2 a 0,40 e 1,00, durante o período de isquemia-reperfusão, apresentou menor diminuição da PAM, melhor relação PO2/FiO2, maior valor na medida da GSH, menor produção das TBARS e menor formação de edema pulmonar. CONCLUSÃO: A ventilação com baixa FiO2 (0,21 mostrou melhores resultados quando comparada àquelas realizadas com FiO2 mais elevadas (0,40 e 1,00 na isquemia-reperfusão pulmonar.PURPOSE: To evaluate the FiO2 effect at 0,21, 0,40 and 1,00 on the lung ischaemia-reperfusion injury. METHODS: Forty Wistar rats were randomly allocated in 4 groups. The group I was the control one, and in groups II, III, IV rats were ventilated during the ischaemia-reperfusion at 0,21, 0,40 and 1.00 FiO2 respectively. The ischaemia time was 30 minutes and the reperfusion time was 10 minutes. The model used was normothermic ischaemia-reperfusion, in situ. As assessment parameters, the systemic average arterial pressure (PAM, the oxygen arterial partial pressure

  13. Protective effects of udenafil citrate, piracetam and dexmedetomidine treatment on testicular torsion/detorsion-induced ischaemia/reperfusion injury in rats.

    Science.gov (United States)

    Tuglu, D; Yuvanc, E; Ozan, T; Bal, F; Yilmaz, E; Atasoy, P; Kisa, U; Batislam, E

    2016-08-01

    The aim of this study was to investigate the antioxidant properties of udenafil citrate (1.4 mg kg(-1) -2.8 mg kg(-1) ), dexmedetomidine 25 μg kg(-1) and piracetam 200 mg kg(-1) administered on ipsilateral/contralateral testes after ischaemia in a rat model of testicular torsion/detorsion (T/D) and define its protective effect histologically. Fifty-six Wistar albino rats were included and randomly assigned into 6 groups. No intervention was performed in control group (Group 1, n = 8) and in torsion/detorsion group, (Group 2, n = 8). Udenafil 1.4 mg kg(-1) was given to torsion/detorsion group (Group 3, n = 10), udenafil 2.8 mg kg(-1) was given to torsion/detorsion group (Group 4, n = 10), piracetam 200 mg kg(-1) was given to torsion/detorsion group (Group 5, n = 10) and dexmedetomidine 25 μg kg(-1) was given to torsion/detorsion group (Group 6, n = 10) intraperitoneally after 60 mins of testicular torsion. Biochemical and histopathological testicular injury were evaluated. When the tissue was examined by TOS values, Group 3, Group 4 and Group 5 were significantly lower than Group 2. In contrary Group 6 values were significantly higher than Group 2. The increasing doses of udenafil demonstrated antioxidant properties on the testis tissue and histopathological that protects the testicles. © 2015 Blackwell Verlag GmbH.

  14. Preventive Treatment with Ketamine Attenuates the Ischaemia-Reperfusion Response in a Chronic Postischaemia Pain Model

    Directory of Open Access Journals (Sweden)

    Suryamin Liman

    2015-01-01

    Full Text Available Ischemia and inflammation may be pathophysiological mechanisms of complex regional pain syndrome (CRPS. Ketamine has proposed anti-inflammatory effects and has been used for treating CRPS. This study aimed to evaluate anti-inflammatory and analgesic effects of ketamine after ischaemia-reperfusion injury in a chronic postischaemia pain (CPIP model of CRPS-I. Using this model, ischemia was induced in the hindlimbs of male Sprague-Dawley rats. Ketamine, methylprednisolone, or saline was administered immediately after reperfusion. Physical effects, (oedema, temperature, and mechanical and cold allodynia in the bilateral hindpaws, were assessed from 48 hours after reperfusion. Fewer (56% rats in the ketamine group developed CPIP at the 48th hour after reperfusion (nonsignificant. Ketamine treated rats showed a significantly lower temperature in the ischaemic hindpaw compared to saline (P<0.01 and methylprednisolone (P<0.05 groups. Mechanical and cold allodynia were significantly lower in the ischaemic side in the ketamine group (P<0.05. Proinflammatory cytokines TNF-α and IL-2 were significantly lower at the 48th hour after reperfusion in ketamine and methylprednisolone groups, compared to saline (all P<0.05. In conclusion, immediate administration of ketamine after an ischaemia-reperfusion injury can alleviate pain and inflammation in the CPIP model and has potential to treat postischaemic pain.

  15. Measurement of ischaemia-reperfusion in patients with intermittent claudication using NMR-based metabonomics.

    NARCIS (Netherlands)

    Coolen, S.A.; Daykin, C.A.; Duynhoven, J.P. van; Dorsten, F.A. van; Wulfert, F.; Mathot, J.; Scheltinga, M.R.M.; Stroosma, O.; Vader, H.L.; Wijnen, M.H.W.A.

    2008-01-01

    Intermittent claudication has proved to be a good in vivo model for ischaemia-reperfusion. For assessment of ischaemia-reperfusion damage, the known biochemical markers all have disadvantages with respect to sensitivity and interference with other physiological events. In this work, we studied the

  16. Dexmedetomidine protects from post-myocardial ischaemia reperfusion lung damage in diabetic rats

    Science.gov (United States)

    Kip, Gülay; Çelik, Ali; Bilge, Mustafa; Alkan, Metin; Kiraz, Hasan Ali; Özer, Abdullah; Şıvgın, Volkan; Erdem, Özlem; Arslan, Mustafa; Kavutçu, Mustafa

    2015-01-01

    Objective Diabetic complications and lipid peroxidation are known to have a close association. Lipid peroxidation commonly occurs at sites exposed to ischaemia, but distant organs and tissues also get damaged during ischaemia/reperfusion (I/R). Some of these targets are vital organs, such as the lung, liver, and kidney; the lung is the most frequently affected. The aim of our study was to investigate the effects of dexmedetomidine on I/R damage in lung tissue and on the oxidant/anti-oxidant system in diabetic rats. Material and methods Diabetes was induced with streptozotocin (55 mg/kg) in 18 Wistar Albino rats, which were then randomly divided into three groups (diabetes control (DC), diabetes plus ischaemia-reperfusion (DIR), and diabetes plus dexmedetomidine-ischaemia/reperfusion (DIRD)) after the effects of diabetes were clearly evident. The rats underwent a left thoracotomy and then ischaemia was produced in the myocardium muscle by a left anterior descending artery ligation for 30 min in the DIR and DIRD groups. I/R was performed for 120 min. The DIRD group received a single intraperitoneal dose of dexmedetomidine (100 µg/kg); the DIR group received no dexmedetomidine. Group DC was evaluated as the diabetic control group and also included six rats (C group) in which diabetes was not induced. These mice underwent only left thoracotomy and were closed without undergoing myocardial ischaemia. Histopathological changes, activities of catalase (CAT) and glutathione-S-transferase anti-oxidant enzymes, and malondialdehyde (MDA) levels were evaluated in the lung tissues of all rats. Results Neutrophil infiltration/aggregation was higher in the DIR group than in the C, DC, and DIRD groups (p=0.001, p=0.013, and p=0.042, respectively). The lung injury score was significantly higher in the DIR group than in the C and DC groups (p<0.0001 and p=0.024, respectively). The levels of MDA were significantly higher in the DIR group than in the C and DIRD groups. CAT activity

  17. Dexmedetomidine protects from post-myocardial ischaemia reperfusion lung damage in diabetic rats

    Directory of Open Access Journals (Sweden)

    Gülay Kip

    2015-09-01

    Full Text Available Objective: Diabetic complications and lipid peroxidation are known to have a close association. Lipid peroxidation commonly occurs at sites exposed to ischaemia, but distant organs and tissues also get damaged during ischaemia/reperfusion (I/R. Some of these targets are vital organs, such as the lung, liver, and kidney; the lung is the most frequently affected. The aim of our study was to investigate the effects of dexmedetomidine on I/R damage in lung tissue and on the oxidant/anti-oxidant system in diabetic rats. Material and methods: Diabetes was induced with streptozotocin (55 mg/kg in 18 Wistar Albino rats, which were then randomly divided into three groups (diabetes control (DC, diabetes plus ischaemia-reperfusion (DIR, and diabetes plus dexmedetomidine-ischaemia/reperfusion (DIRD after the effects of diabetes were clearly evident. The rats underwent a left thoracotomy and then ischaemia was produced in the myocardium muscle by a left anterior descending artery ligation for 30 min in the DIR and DIRD groups. I/R was performed for 120 min. The DIRD group received a single intraperitoneal dose of dexmedetomidine (100 µg/kg; the DIR group received no dexmedetomidine. Group DC was evaluated as the diabetic control group and also included six rats (C group in which diabetes was not induced. These mice underwent only left thoracotomy and were closed without undergoing myocardial ischaemia. Histopathological changes, activities of catalase (CAT and glutathione-S-transferase anti-oxidant enzymes, and malondialdehyde (MDA levels were evaluated in the lung tissues of all rats. Results: Neutrophil infiltration/aggregation was higher in the DIR group than in the C, DC, and DIRD groups (p=0.001, p=0.013, and p=0.042, respectively. The lung injury score was significantly higher in the DIR group than in the C and DC groups (p<0.0001 and p=0.024, respectively. The levels of MDA were significantly higher in the DIR group than in the C and DIRD groups. CAT

  18. Effects of Intestinal Ischaemia-Reperfusion Injury and Splenectomy ...

    African Journals Online (AJOL)

    The rats were splenectomized and then subjected to either 20minutes or one hour of superior mesenteric artery and collateral supply ischemia and one hour of reperfusion. Control rats were subjected to either 20minutes or one hour of ischemia and one hour of reperfusion only. Blood samples were collected before and ...

  19. Effect of black tea consumption on brachial artery flow-mediated dilation and ischaemia-reperfusion in humans.

    Science.gov (United States)

    Schreuder, Tim H A; Eijsvogels, Thijs M H; Greyling, Arno; Draijer, Richard; Hopman, Maria T E; Thijssen, Dick H J

    2014-02-01

    Tea consumption is associated with reduced cardiovascular risk. Previous studies found that tea flavonoids work through direct effects on the vasculature, leading to dose-dependent improvements in endothelial function. Cardioprotective effects of regular tea consumption may relate to the prevention of endothelial ischaemia-reperfusion (IR) injury. Therefore, we examined the effect of black tea consumption on endothelial function and the ability of tea to prevent IR injury. In a randomized, crossover study, 20 healthy subjects underwent 7 days of tea consumption (3 cups per day) or abstinence from tea. We examined brachial artery (BA) endothelial function via flow-mediated dilation (FMD), using high resolution echo-Doppler, before and 90 min after tea or hot water consumption. Subsequently, we followed a 20-min ischaemia and 20-min reperfusion protocol of the BA after which we measured FMD to examine the potential of tea consumption to protect against IR injury. Tea consumption resulted in an immediate increase in FMD% (pre-consumption: 5.8 ± 2.5; post-consumption: 7.2 ± 3.2; p FMD (p FMD. However, the impact of the IR protocol on FMD was not influenced by tea consumption. Therefore, the cardioprotective association of tea ingestion relates to a direct effect of tea on the endothelium in humans in vivo.

  20. Effects of electroacupuncture on the cortical extracellular signal regulated kinase pathway in rats with cerebral ischaemia/reperfusion.

    Science.gov (United States)

    Wu, Chunxiao; Li, Chun; Zhou, Guoping; Yang, Lu; Jiang, Guimei; Chen, Jing; Li, Qiushi; Zhan, Zhulian; Xu, Xiuhong; Zhang, Xin

    2017-12-01

    To explore the effects of electroacupuncture (EA) on the phosphorylated extracellular signal regulated kinase (p-ERK) pathway of the cerebral cortex in a rat model of focal cerebral ischaemia/reperfusion (I/R). 160 adult Sprague-Dawley rats underwent middle carotid artery occlusion (MCAO) to establish I/R injury and were randomly divided into four groups (n=40 each) that remained untreated (I/R group) or received EA at LU5, LI4, ST36 and SP6 (I/R+EA group), the ERK inhibitor PD98059 (I/R+PD group), or both interventions (I/R+PD+EA groups). An additional 40 rats undergoing sham surgery formed a healthy control group. Eight rats from each group were sacrificed at the following time points: 2 hours, 6 hours, 1 day, 3 days and 1 week. Neurological function was assessed using neurological deficit scores, morphological examination was performed following haematoxylin-eosin staining of cortical tissues, and apoptotic indices were calculated after terminal deoxyribonucleotidyl transferase (TdT)-mediated biotin-16-dUTP nick-end labelling. Cortical protein and mRNA expression of p-ERK and ERK were measured by immunohistochemistry and real-time quantitative PCR, respectively. Compared with the I/R group, neurological deficit scores and apoptotic indices were lower in the I/R+EA group at 1 and 3 days, whereas mRNA/protein expression of ERK/p-ERK was higher in the EA group at all time points studied. Our results suggest that EA can alleviate neurological deficits and reduce cortical apoptosis in rats with I/R injury. These anti-apoptotic effects may be due to upregulation of p-ERK. Moreover, apoptosis appeared to peak at 1 day after I/R injury, which might therefore represent the optimal time point for targeting of EA. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  1. Protective effects of Urtica dioica L. on experimental testicular ischaemia reperfusion injury in rats.

    Science.gov (United States)

    Aktas, C; Erboga, M; Fidanol Erboga, Z; Bozdemir Donmez, Y; Topcu, B; Gurel, A

    2017-05-01

    In this study, it was aimed to examine the effects of Urtica dioica L. (UD) that has antioxidant feature in the experimental testicular I/R model in rats in terms of anti-apoptotic and antioxidative effects. In our study, 24 male rats were divided into three groups: control group, I/R group and I/R + UD (2 mg kg -1 ) group. Seminiferous tubule calibre measurement, Johnson score, haematoxylin-eosin staining, proliferative cell nucleus antigen (PCNA) immunohistochemical staining and TUNEL as histopathological have been conducted. The structural deterioration in the testicular on I/R group has reduced after the treatment of UD. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end labelling (TUNEL), and there was a rise in the expression of proliferating cell nuclear antigen (PCNA) in testis tissues of UD-treated rats in the I/R group. The I/R + UD group showed a decrease in malondialdehyde levels and an increase in the activities of superoxide dismutase, catalase and glutathione peroxidase in comparison with the I/R group. It could be concluded that protective effects of UD on the I/R testicles are via reduction of histological damage, apoptosis, oxidative stress and lipid peroxidation. © 2016 Blackwell Verlag GmbH.

  2. Thrombin inhibition with melagatran does not attenuate renal ischaemia-reperfusion injury in rats

    DEFF Research Database (Denmark)

    Nitescu, Nicoletta; Grimberg, Elisabeth; Ricksten, Sven-Erik

    2007-01-01

    characterized by tubular necrosis and atrophy, tubular cast formation and interstitial inflammation. In addition, there was significant vascular congestion in the inner stripe of the outer medullary zone. Melagatran treatment had no significant effects on any of the abnormalities in kidney morphology...

  3. Lower limb ischaemia and reperfusion injury in healthy volunteers measured by oxidative and inflammatory biomarkers

    DEFF Research Database (Denmark)

    Halladin, N. L.; Busch, Sarah Victoria Ekeløf; Alamili, M.

    2015-01-01

    OBJECTIVE: Ischaemia-reperfusion (IR) injury is partly caused by the release of reactive oxygen species and cytokines and may result in remote organ injury. Surgical patients are exposed to surgical stress and anaesthesia, both of which can influence the IR response. An IR model without these int......OBJECTIVE: Ischaemia-reperfusion (IR) injury is partly caused by the release of reactive oxygen species and cytokines and may result in remote organ injury. Surgical patients are exposed to surgical stress and anaesthesia, both of which can influence the IR response. An IR model without...... at any sampling time. CONCLUSION: Twenty minutes of lower limb ischaemia does not result in an ischaemia-reperfusion injury in healthy volunteers, measurable by oxidative and pro- and anti-inflammatory biomarkers in muscle biopsies and in the systemic circulation....

  4. The cardioprotective efficacy of TVP1022 in a rat model of ischaemia/reperfusion.

    Science.gov (United States)

    Ertracht, Offir; Liani, Esti; Bachner-Hinenzon, Noa; Bar-Am, Orit; Frolov, Luba; Ovcharenko, Elena; Awad, Huda; Blum, Shany; Barac, Yaron; Amit, Tamar; Adam, Dan; Youdim, Moussa; Binah, Ofer

    2011-06-01

    Because myocardial infarction is a major cause of morbidity and mortality worldwide, protecting the heart from the ischaemia and reperfusion (I/R) damage is the focus of intense research. Based on our in vitro findings showing that TVP1022 (the S-enantiomer of rasagiline, an anti-Parkinsonian drug) possesses cardioprotective effects, in the present study we investigated the hypothesis that TVP1022 can attenuate myocardial damage in an I/R model in rats. The model consisted of 30-min occlusion of the left anterior descending artery followed by 4 or 24 h reperfusion. In addition, we investigated the possible mechanisms of cardioprotection in H9c2 cells and neonatal rat ventricular myocytes (NRVM) exposed to oxidative stress induced by H(2) O(2) . TVP1022 (20 and 40 mg·kg(-1) ) administered 5 min before reperfusion followed by an additional dose 4 h after reperfusion reduced the infarct size and attenuated the decline in ventricular function. TVP1022 also attenuated I/R-induced deterioration in cardiac mitochondrial integrity evaluated by mitochondrial swelling capacity. In vitro, using H9c2 cells and NRVM, TVP1022 attenuated both serum free- and H(2) O(2) -induced damage, preserved mitochondrial membrane potential and Bcl-2 levels, inhibited mitochondrial cytochrome c release and the increase in cleaved caspase 9 and 3 levels, and enhanced the phosphorylation of protein kinase C and glycogen synthase kinase-3β. TVP1022 provided cardioprotection in a model of myocardial infarction, and therefore should be considered as a novel adjunctive therapy for attenuating myocardial damage resulting from I/R injuries. © 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.

  5. Cardioprotective effect of hyperthyroidism on the stunned rat heart during ischaemia-reperfusion: energetics and role of mitochondria.

    Science.gov (United States)

    Ragone, María Inés; Bonazzola, Patricia; Colareda, Germán A; Consolini, Alicia E

    2015-06-01

    What is the central question of this study? Hyperthyroidism is a cardiac risk factor, but thyroid therapy is used on myocardial stunning. What is the consequence of hyperthyroidism for mitochondrial metabolism and Ca(2+) handling of the postischaemic stunned heart? What is the main finding and its importance? Hyperthyroidism reduced stunning and improved muscle economy of the postischaemic rat heart. The activities of the mitochondrial sodium-calcium exchanger and mitochondrial K(+) channel in hyperthyroid rat hearts were different from those in the euthyroid rat hearts. These findings contribute to the understanding of mitochondrial bioenergetics in pathology and support thyroid therapy in the stunning induced by ischaemia. Transient ischaemia and hyperthyroidism are cardiovascular risk factors. Nevertheless, 3,5,3'-triiodothyronine/thyroxine therapy has been used to revert myocardial stunning. We studied the influence of hyperthyroidism on the role played by mitochondria in myocardial stunning consequent to ischaemia-reperfusion. Rats were injected s.c. daily with 20 μg kg(-1) triiodothyronine for 15 days (HpT group). Isolated ventricles from either HpT or euthyroid (EuT) rats were perfused in a calorimeter, and left intraventricular pressure (in millimetres of mercury) and heat release (Ht; in milliwatts per gram) were measured. Stunning was evoked by 20 min of no-flow ischaemia and 45 min reperfusion. The HpT hearts developed higher postischaemic contractile recovery (PICR) and improved total muscle economy (P/Ht) with lower diastolic contracture (ΔLVEDP) than EuT hearts. Release of Ca(2+) from the sarcoplasmic reticulum during reperfusion with 10 mm caffeine in low-[Na(+) ] Krebs solution evoked a higher contracture in EuT than in HpT hearts. Blockade of the mitochondrial sodium-calcium exchanger with clonazepam increased ΔLVEDP and reduced P/Ht and PICR in HpT but not in EuT hearts. The clonazepam-induced dysfunction in HpT hearts was reduced by

  6. Effects of defibrotide, a novel oligodeoxyribonucleotide, on ischaemia and reperfusion injury of the rat liver.

    Science.gov (United States)

    Kim, Kwang Joon; Shin, Yong Kyoo; Song, Jin Ho; Oh, Byung Kwon; Choi, Myung Sup; Sohn, Uy Dong

    2002-02-01

    1. The purpose of this study was to investigate the protective effects of defibrotide, a single-stranded polydeoxyribonucleotide, on ischaemia-reperfusion injury to the liver using a rat model. 2. Ischaemia of the left and median lobes was created by total inflow occlusion for 30 min followed by 60 min of reperfusion. Hepatic injury was assessed by the release of liver enzymes (alanine transferase, ALT and lactic dehydrogenase, LDH). Hepatic oxidant stress was measured by superoxide production, lipid peroxidation and nitrite/nitrate formation. Leukocyte-endothelium interaction and Kupffer cell mobilization were quantified by measuring hepatic myeloperoxidase (MPO), polymorphonuclear leukocyte adherence to superior mesenteric artery (SMA) and immunostaining of Kupffer cell. 3. Defibrotide treatment resulted in a significant inhibition of postreperfusion superoxide generation, lipid peroxidation, serum ALT activity, serum LDH activity, MPO activity, serum nitrite/nitrate level, leukocyte adherence to SMA, and Kupffer cell mobilization, indicating a significant attenuation of hepatic dysfunction. 4. A significant correlation existed between liver ischaemia/reperfusion and hepatic injury, suggesting that liver ischaemia/reperfusion injury is mediated predominantly by generation of oxygen free radicals and mobilization of Kupffer cells. 5. We conclude that defibrotide significantly protects the liver against liver ischaemia/reperfusion injury by interfering with Kupffer cell mobilization and formation of oxygen free radicals. This study provides strong evidence that defibrotide has important beneficial effects on acute inflammatory tissue injury such as that occurring in the reperfusion of the ischaemic liver.

  7. Human bone marrow mesenchymal stem cells for retinal vascular injury.

    Science.gov (United States)

    Wang, Jin-Da; An, Ying; Zhang, Jing-Shang; Wan, Xiu-Hua; Jonas, Jost B; Xu, Liang; Zhang, Wei

    2017-09-01

    To examine the potential of intravitreally implanted human bone marrow-derived mesenchymal stem cells (BMSCs) to affect vascular repair and the blood-retina barrier in mice and rats with oxygen-induced retinopathy, diabetic retinopathy or retinal ischaemia-reperfusion damage. Three study groups (oxygen-induced retinopathy group: 18 C57BL/6J mice; diabetic retinopathy group: 15 rats; retinal ischaemia-reperfusion model: 18 rats) received BMSCs injected intravitreally. Control groups (oxygen-induced retinopathy group: 12 C57BL/6J mice; diabetic retinopathy group: 15 rats; retinal ischaemia-reperfusion model: 18 rats) received an intravitreal injection of phosphate-buffered saline. We applied immunohistological techniques to measure retinal vascularization, spectroscopic measurements of intraretinally extravasated fluorescein-conjugated dextran to quantify the blood-retina barrier breakdown, and histomorphometry to assess retinal thickness and retinal ganglion cell count. In the oxygen-induced retinopathy model, the study group with intravitreally injected BMSCs as compared with the control group showed a significantly (p = 0.001) smaller area of retinal neovascularization. In the diabetic retinopathy model, study group and control group did not differ significantly in the amount of intraretinally extravasated dextran. In the retinal ischaemia-reperfusion model, on the 7th day after retina injury, the retina was significantly thicker in the study group than in the control group (p = 0.02), with no significant difference in the retinal ganglion cell count (p = 0.36). Intravitreally implanted human BMSCs were associated with a reduced retinal neovascularization in the oxygen-induced retinopathy model and with a potentially cell preserving effect in the retinal ischaemia-reperfusion model. Intravitreal BMSCs may be of potential interest for the therapy of retinal vascular disorders. © 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley

  8. Novel aspects of acute coronary syndromes, reperfusion injury and post-infarction myocardial fibrosis

    OpenAIRE

    Chan, William

    2017-01-01

    This thesis comprises 4 clinical studies aiming to explore the mechanisms related to coronary plaque destabilization, clinical outcomes of the no-reflow phenomenon, a novel treatment of ischaemia-reperfusion injury, and the pattern and temporal evolution of left ventricular myocardial fibrosis following myocardial infarction. Current risk prediction models for future cardiovascular events are derived from large scale population-based studies (such as that from the Framingham Heart Study),...

  9. Anti neuroinflammatory effect of Vildagliptin in ischaemia-reperfusion induced cerebral infarction in normal and STZ induced type-II diabetic rats

    Directory of Open Access Journals (Sweden)

    Kaleru Purnachander

    2016-03-01

    Full Text Available Diabetes is one of the major risk factor for cerebral ischemic stroke. Increased base line levels of oxidative stress in diabetes will lead to cerebral ischemic damage. In pathological conditions such as cerebral ischemia/reperfusion injury, free radicals cause oxidative stress and inflammation leading to increased injury of brain. Inflammation is one of the major pathological mechanisms involved in cerebral ischemia and reperfusion injury. Vildagliptin newer anti-diabetic drug of the class DPP-4 inhibitors is reported to have anti-inflammatory properties apart from its antihyperglycemic activity. Therefore the aim of the present study is to evaluate the anti-inflammatory effect of Vildagliptin against cerebral infarction induced ischemia reperfusion injury in normal and STZ induced diabetic Wistar rats. Cerebral infarction was induced by bilateral common carotid artery occlusion followed by 4 hr reperfusion. Percent infarction, inflammatory markers such as MPO, TNF-α, IL-6 and IL-10 were analysed. Treatment with Vildagliptin for a period of four weeks produced significant reduction in percent cerebral infarct volume. Vildagliptin at 10 mg/kg dose, showed significant reduction in markers like MPO, TNF-α, IL-6 and IL-1β in diabetic group when compared to normal group and in contrast significant increase in anti-inflammatory marker like IL-10 levels. Vildagliptin showed significant cerebroprotective effect by antiinflammatory mechanisms.

  10. Treatment of Tourniquet-Induced Ischemia Reperfusion Injury with Muscle Progenitor Cells

    Science.gov (United States)

    2011-09-01

    of loss in muscle-specific force following IRI is unclear, studies in aging and sports injury models show that muscle-specific force can be reduced... antioxidant effects of carvedilol in a rat model of ischaemia-reperfusion injury. J Int Med Res 2005;33:528. 13. Asami A, Orii M, Shirasugi N, et al...Lowe DA, et al. What mechanisms con- tribute to the strength loss that occurs during and in the recov- ery from skeletal muscle injury? J Orthop Sports

  11. Cardioprotective effects of benazepril, an angiotensin-converting enzyme inhibitor, in an ischaemia-reperfusion model of myocardial infarction in rats.

    Science.gov (United States)

    Charan Sahoo, Kanhei; Arora, Sachin; Goyal, Sameer; Kishore, Kamal; Ray, Ruma; Chandra Nag, Tapas; Singh Arya, Dharamvir

    2009-12-01

    The present study evaluated the effects of benazepril, an angiotensin-converting enzyme inhibitor on haemodynamic, biochemical, and immunohistochemical (Bax and Bcl-2 protein) indices in ischaemia and reperfusion (IR) injury. Male Wistar albino rats were divided into three groups and were orally administered saline once daily (IR-sham and IR-control) or benazepril (30 mg/kg/day; IR-benazepril) for 14 days. On the 15(th) day, in the IR-control and IR-benazepril groups, rats were subjected to left anterior descending coronary artery occlusion for 45 minutes followed by a one-hour reperfusion. Haemodynamic parameters were recorded and rats were sacrificed; hearts were isolated for biochemical estimation and immunohistochemistry. In the IR-control group, significant ventricular dysfunctions (pBenazepril pretreatment significantly improved mean arterial pressure (pbenazepril treatment significantly decreased the level of thiobarbituric acid reactive substances and restored the activity of lactate dehydrogenase towards normal value (pbenazepril upregulated Bcl-2 protein and decreased Bax protein expression, thus exhibiting anti-apoptotic effects. These beneficial effects of benazepril will have an important implication in the therapeutic use of benazepril in ischaemic heart disease.

  12. Intracoronary and systemic melatonin to patients with acute myocardial infarction

    DEFF Research Database (Denmark)

    Halladin, Natalie L; Busch, Sarah Ekeløf; Jensen, Svend Eggert

    2014-01-01

    INTRODUCTION: Ischaemia-reperfusion injury following acute myocardial infarctions (AMI) is an unavoidable consequence of the primary percutaneous coronary intervention (pPCI) procedure. A pivotal mechanism in ischaemia-reperfusion injury is the production of reactive oxygen species following...

  13. Ankle Injuries: Reduce the Risk by Using a Soccer-Specific Warm-up Routine

    Science.gov (United States)

    Elliott, Steven; Ellis, Margery; Combs, Sue; Hunt Long, Lynn

    2015-01-01

    Injuries to the ankle are among the most common injuries for soccer players at any age. Soccer coaches should be aware of current research and best practices that suggest it is possible to decrease the incidence of soccer players' ankle injuries by providing an appropriate warm-up to utilize prior to practices and games. This article introduces…

  14. Doxorubicin induced myocardial injury is exacerbated following ischaemic stress via opening of the mitochondrial permeability transition pore

    Energy Technology Data Exchange (ETDEWEB)

    Gharanei, M.; Hussain, A. [Department of Biomolecular and Sport Sciences, Coventry University, Cox Street, Coventry, CV1 5FB (United Kingdom); Janneh, O. [Department of Biomolecular and Sport Sciences, Coventry University, Cox Street, Coventry, CV1 5FB (United Kingdom); Pharmacology Research Laboratories, 70, Pembroke Place, The University of Liverpool, Liverpool. L69 3GF (United Kingdom); Maddock, H.L., E-mail: h.maddock@coventry.ac.uk [Department of Biomolecular and Sport Sciences, Coventry University, Cox Street, Coventry, CV1 5FB (United Kingdom)

    2013-04-15

    Chemotherapeutic agents such as doxorubicin are known to cause or exacerbate cardiovascular cell death when an underlying heart condition is present. However, the mechanism of doxorubicin-induced cardiotoxicity is unclear. Here we assess the cardiotoxic effects of doxorubicin in conditions of myocardial ischaemia reperfusion and the mechanistic basis of protection, in particular the role of the mitochondrial permeability transition pore (mPTP) in such protection. The effects of doxorubicin (1 μM) ± cyclosporine A (CsA, 0.2 μM; inhibits mPTP) were investigated in isolated male Sprague–Dawley rats using Langendorff heart and papillary muscle contraction models subjected to simulated ischaemia and reperfusion injury. Isolated rat cardiac myocytes were used in an oxidative stress model to study the effects of drug treatment on mPTP by confocal microscopy. Western blot analysis evaluated the effects of drug treatment on p-Akt and p-Erk 1/2 levels. Langendorff and the isometric contraction models showed a detrimental effect of doxorubicin throughout reperfusion/reoxygenation as well as increased p-Akt and p-Erk levels. Interestingly, CsA not only reversed the detrimental effects of doxorubicin, but also reduced p-Akt and p-Erk levels. In the sustained oxidative stress assay to study mPTP opening, doxorubicin decreased the time taken to depolarization and hypercontracture, but these effects were delayed in the presence of CsA. Collectively, our data suggest for the first that doxorubicin exacerbates myocardial injury in an ischaemia reperfusion model. If the inhibition of mPTP ameliorates the cardiotoxic effects of doxorubicin, then more selective inhibitors of mPTP should be further investigated for their utility in patients receiving doxorubicin. - Highlights: ► Doxorubicin exacerbates myocardial ischaemia reperfusion injury. ► Co-treatment with CsA protects against doxorubicin induced myocardial injury. ► CsA delays doxorubicin induced mPTP opening in laser

  15. Doxorubicin induced myocardial injury is exacerbated following ischaemic stress via opening of the mitochondrial permeability transition pore

    International Nuclear Information System (INIS)

    Gharanei, M.; Hussain, A.; Janneh, O.; Maddock, H.L.

    2013-01-01

    Chemotherapeutic agents such as doxorubicin are known to cause or exacerbate cardiovascular cell death when an underlying heart condition is present. However, the mechanism of doxorubicin-induced cardiotoxicity is unclear. Here we assess the cardiotoxic effects of doxorubicin in conditions of myocardial ischaemia reperfusion and the mechanistic basis of protection, in particular the role of the mitochondrial permeability transition pore (mPTP) in such protection. The effects of doxorubicin (1 μM) ± cyclosporine A (CsA, 0.2 μM; inhibits mPTP) were investigated in isolated male Sprague–Dawley rats using Langendorff heart and papillary muscle contraction models subjected to simulated ischaemia and reperfusion injury. Isolated rat cardiac myocytes were used in an oxidative stress model to study the effects of drug treatment on mPTP by confocal microscopy. Western blot analysis evaluated the effects of drug treatment on p-Akt and p-Erk 1/2 levels. Langendorff and the isometric contraction models showed a detrimental effect of doxorubicin throughout reperfusion/reoxygenation as well as increased p-Akt and p-Erk levels. Interestingly, CsA not only reversed the detrimental effects of doxorubicin, but also reduced p-Akt and p-Erk levels. In the sustained oxidative stress assay to study mPTP opening, doxorubicin decreased the time taken to depolarization and hypercontracture, but these effects were delayed in the presence of CsA. Collectively, our data suggest for the first that doxorubicin exacerbates myocardial injury in an ischaemia reperfusion model. If the inhibition of mPTP ameliorates the cardiotoxic effects of doxorubicin, then more selective inhibitors of mPTP should be further investigated for their utility in patients receiving doxorubicin. - Highlights: ► Doxorubicin exacerbates myocardial ischaemia reperfusion injury. ► Co-treatment with CsA protects against doxorubicin induced myocardial injury. ► CsA delays doxorubicin induced mPTP opening in laser

  16. The effect of prolonged of warm ischaemic injury on renal function in an experimental ex vivo normothermic perfusion system.

    Science.gov (United States)

    Hosgood, Sarah A; Shah, K; Patel, M; Nicholson, M L

    2015-06-30

    Donation after circulatory death (DCD) kidney transplants inevitably sustain a degree of warm ischaemic injury, which is manifested clinically as delayed graft function. The aim of this study was to define the effects of prolonged periods of warm ischaemic injury on renal function in a normothermic haemoperfused kidney model. Porcine kidneys were subjected to 15, 60, 90 (n = 6 per group) and 120 min (n = 4) of in situ warm ischaemia (WI) and then retrieved, flushed with cold preservation fluid and stored in ice for 2 h. Kidneys then underwent 3 h of normothermic reperfusion with a whole blood-based perfusate using an ex vivo circuit developed from clinical grade cardiopulmonary bypass technology. Creatinine clearance, urine output and fractional excretion of sodium deteriorated sequentially with increasing warm time. Renal function was severely compromised after 90 or 120 min of WI but haemodynamic, metabolic and histological parameters demonstrated the viability of kidneys subjected to prolonged warm ischaemia. Isolated kidney perfusion using a warm, oxygenated, red cell-based perfusate allows an accurate ex vivo assessment of the potential for recovery from warm ischaemic injury. Prolonged renal warm ischaemic injury caused a severe decrement in renal function but was not associated with tissue necrosis.

  17. S-Adenosylmethionine attenuates bile duct early warm ischemia reperfusion injury after rat liver transplantation.

    Science.gov (United States)

    Tang, Yong; Chu, Hongpeng; Cao, Guojun; Du, Xiaolong; Min, Xiaobo; Wan, Chidan

    2018-03-01

    Warm ischemia reperfusion injury (IRI) plays a key role in biliary complication, which is a substantial vulnerability of liver transplantation. The early pathophysiological changes of IRI are characterized by an excessive inflammatory response. S-Adenosylmethionine (SAM) is an important metabolic intermediate that modulates inflammatory reactions; however, its role in bile duct warm IRI is not known. In this study, male rats were treated with or without SAM (170 μmol/kg body weight) after orthotopic autologous liver transplantation. The histopathological observations showed that bile duct injury in the IRI group was more serious than in the SAM group. The alanine aminotransferase (ALT), alkaline phosphatase (ALP) and direct bilirubin (DBIL) levels in the serum of the IRI group were significantly increased compared to the SAM group (P liver and bile duct tissues, down-regulated TNF-α levels and up-regulated IL-10 expression in bile duct tissues compared to the IRI group (P livers were much higher compared to those in SAM-treated rats at 24 h after liver transplantation (P bile ducts against warm IRI by suppressing oxidative stress, inflammatory reactions and apoptosis of biliary epithelial cells after liver transplantation.α. Copyright © 2018 Elsevier Ltd. All rights reserved.

  18. The “FIFA 11+” warm-up programme for preventing injuries in soccer players: a systematic review

    Directory of Open Access Journals (Sweden)

    Alex de Andrade Fernandes

    Full Text Available Introduction Soccer is among the sports with the highest injury rate. A group of international experts from the Fédération Internationale de Football Association — FIFA’s Medical Assessment and Research Centre — have developed the “FIFA 11+”, a warm-up programme whose main goal is to reduce the risk of common injuries in both male and female soccer players. Objective To conduct a literature review in order to check the efficiency of the “FIFA 11 +” warm-up programme in preventing injuries in soccer players. Methods We conducted a systematic review of studies in the databases MEDLINE/PubMed, SciELO, ScienceDirect and SPORTDiscus, using the following keywords in combination with one another: “injury”, “prevention” and “warm-up”. Results Five studies met the inclusion criteria. In four studies, the authors conclude that the “FIFA 11 +” warm-up programme is effective for preventing injuries in soccer players. In one study, this protective effect was not observed. Conclusion The analyzed studies indicate that the FIFA 11+ warm-up programme for the prevention of sports injuries show positive signs that the use of the programme may help reduce the incidence of injuries in girls aged 13–17 years. In a male children population the results are inconclusive and further research is needed.

  19. Arterial Injury and Endothelial Repair: Rapid Recovery of Function after Mechanical Injury in Healthy Volunteers

    Directory of Open Access Journals (Sweden)

    Lindsey Tilling

    2014-01-01

    Full Text Available Objective. Previous studies suggest a protracted course of recovery after mechanical endothelial injury; confounders may include degree of injury and concomitant endothelial dysfunction. We sought to define the time course of endothelial function recovery using flow-mediated dilation (FMD, after ischaemia-reperfusion (IR and mechanical injury in patients and healthy volunteers. The contribution of circulating CD133+/CD34+/VEGFR2+ “endothelial progenitor” (EPC or repair cells to endothelial repair was also examined. Methods. 28 healthy volunteers aged 18–35 years underwent transient forearm ischaemia induced by cuff inflation around the proximal biceps and radial artery mechanical injury induced by inserting a wire through a cannula. A more severe mechanical injury was induced using an arterial sheath and catheter inserted into the radial artery of 18 patients undergoing angiography. Results. IR and mechanical injury produced immediate impairment of FMD (from 6.5 ± 1.2% to 2.9 ± 2.2% and from 7.4 ± 2.3% to 1.5 ± 1.6% for IR and injury, resp., each P<0.001 but recovered within 6 hours and 2 days, respectively. FMD took up to 4 months to recover in patients. Circulating EPC did not change significantly during the injury/recovery period in all subjects. Conclusions. Recovery of endothelial function after IR and mechanical injury is rapid and not associated with a change in circulating EPC.

  20. Endothelial Injury Associated with Cold or Warm Blood Cardioplegia during Coronary Artery Bypass Graft Surgery

    Directory of Open Access Journals (Sweden)

    Elmar W. Kuhn

    2015-01-01

    Full Text Available The aim of this investigation was to analyze the impact of intermittent cold blood cardioplegia (ICC and intermittent warm blood cardioplegia (IWC on endothelial injury in patients referred to elective on-pump coronary artery bypass graft (CABG surgery. Patients undergoing CABG procedures were randomized to either ICC or IWC. Myocardial injury was assessed by CK-MB and cardiac troponin T (cTnT. Endothelial injury was quantified by circulating endothelial cells (CECs, von Willebrand factor (vWF, and soluble thrombomodulin (sTM. Perioperative myocardial injury (PMI and major adverse cardiac events (MACE were recorded. Demographic data and preoperative risk profile of included patients (ICC: n=32, IWC: n=36 were comparable. No deaths, PMI, or MACE were observed. Levels of CK-MB and cTnT did not show intergroup differences. Concentrations of CECs peaked at 6 h postoperatively with significantly higher values for IWC-patients at 1 h (ICC: 10.1 ± 3.9/mL; IWC: 18.4 ± 4.1/mL; P=0.012 and 6 h (ICC: 19.3 ± 6.2/mL; IWC: 29.2 ± 6.7/mL; P<0.001. Concentrations of vWF (ICC: 178.4 ± 73.2 U/dL; IWC: 258.2 ± 89.7 U/dL; P<0.001 and sTM (ICC: 3.2 ± 2.1 ng/mL; IWC: 5.2 ± 2.4 ng/mL; P=0.011 were significantly elevated in IWC-group at 1 h postoperatively. This study shows that the use of IWC is associated with a higher extent of endothelial injury compared to ICC without differences in clinical endpoints.

  1. Livers from fasted rats acquire resistance to warm and cold ischemia injury.

    Science.gov (United States)

    Sumimoto, R; Southard, J H; Belzer, F O

    1993-04-01

    Successful liver transplantation is dependent upon many factors, one of which is the quality of the donor organ. Previous studies have suggested that the donor nutritional status may affect the outcome of liver transplantation and starvation, due to prolonged stay in the intensive care unit, may adversely affect the liver. In this study we have used the orthotopic rat liver transplant model to measure how fasting the donor affects the outcome of liver transplantation. Rat livers were preserved with UW solution either at 37 degrees C (warm ischemia for 45-60 min) or at 4 degrees C (cold ischemia for 30 or 44 hr). After preservation the livers were orthotopically transplanted and survival (for 7 days) was measured, as well as liver functions 6 hr after transplantation. After 45 min of warm ischemia 50% (3 of 6) animals survived when the liver was obtained from a fed donor about 80% (4 of 5) survived when the liver was obtained from a three-day-fasted donor. After 60 min warm ischemia no animal survived (0 of 8, fed group). However, if the donor was fasted for 3 days 89% (8 of 9) of the animals survived for 7 days. Livers cold-stored for 30 hr were 50% viable (3 of 6) and fasting for 1-3 days did not affect this outcome. However, if the donor was fasted for 4 days 100% (9 of 9) survival was obtained. After 44-hr preservation only 29% (2/7) of the recipients survived for 7 days. If the donor was fasted for 4 days, survival increased to 83% (5/6). Liver functions, bile production, and serum enzymes were better in livers from the fasted rats than from the fed rats. Fasting caused a 95% decrease in liver glycogen content. Even with this low concentration of glycogen, liver viability (animal survival) after warm or cold ischemia was not affected, and livers with a low glycogen content were fully viable. Thus liver glycogen does not appear to be important in liver preservation. This study shows that fasting the donor does not cause injury to the liver after warm or cold

  2. Intermittent warming of 'Tahiti' lime to prevent chilling injury during cold storage

    Directory of Open Access Journals (Sweden)

    Kluge Ricardo Alfredo

    2003-01-01

    Full Text Available Storage of 'Tahiti' limes (Citrus latifolia at low temperature allows the marketing period to be extended. However, the loss of the green skin color and the occurrence of chilling injury (CI prevent this extension. The purpose of this work was to verify the efficiency of intermittent warming (IW in 'Tahiti' lime quality maintenance during cold storage. Fruit were submitted to IW (20ºC for 48 hours every 7 or 14 days or 38ºC for 24 hours every 14 days during cold storage at 5ºC. Fruit were also stored at 5 and 10ºC continuously. The evaluations were carried out after 30 and 60 days of storage (+ 3 days of simulated marketing at 20ºC. CI occurrence on fruit was not verified after 30 days of storage. However, after 60 days of storage 60% of the fruit kept continuously at 5ºC presented CI, while fruit intermittently warmed had 10 to 12.5% CI. Fruit stored at 10ºC did not present CI, but they showed high degreening after 30 days of storage. Fruit warmed at 38ºC for 24 hours every 14 days developed rot, loss of green skin color and vitamin C, high respiratory rates, as well as high levels of ethanol and acetaldehyde in the juice. Fruit can be stored at 5ºC during 30 days, without risk of CI, while IW can be used to reduce CI after 60 days of storage.

  3. Pretreatment with soluble ST2 reduces warm hepatic ischemia/reperfusion injury

    International Nuclear Information System (INIS)

    Yin Hui; Huang Baojun; Yang Heng; Huang Yafei; Xiong Ping; Zheng Fang; Chen Xiaoping; Chen Yifa; Gong Feili

    2006-01-01

    The interleukin-1 receptor-like protein ST2 exists in both membrane-bound (ST2L) and soluble form (sST2). ST2L has been found to play an important regulatory role in Th2-type immune response, but the function of soluble form of ST2 remains to be elucidated. In this study, we report the protective effect of soluble ST2 on warm hepatic ischemia/reperfusion injury. We constructed a eukaryotic expression plasmid, psST2-Fc, which expresses functional murine soluble ST2-human IgG1 Fc (sST2-Fc) fusion protein. The liver damage after ischemia/reperfusion was significantly attenuated by the expression of this plasmid in vivo. sST2-Fc remarkably inhibited the activation of Kupffer cells and the production of proinflammatory mediators TNF-α and IL-6. Furthermore, the levels of TLR4 mRNA and the nuclear translocation of NF-κB were also suppressed by pretreatment with sST2-Fc. These results thus identified soluble ST2 as a negative regulator in hepatic I/R injury, possibly via ST2-TLR4 pathway

  4. Warm Up and Cool Down: Reduce Risk of Injury and Improve Athletic Performance

    Science.gov (United States)

    ... exercise, but more research is needed. Although there's controversy about whether warming up and cooling down can ... your agreement to the Terms and Conditions and Privacy Policy linked below. Terms and Conditions Privacy Policy ...

  5. Remote ischaemic preconditioning and prevention of cerebral injury.

    Science.gov (United States)

    Rehni, Ashish K; Shri, Richa; Singh, Manjeet

    2007-03-01

    Bilateral carotid artery occlusion of 10 min followed by reperfusion for 24 hr was employed in present study to produce ischaemia and reperfusion induced cerebral injury in mice. Cerebral infarct size was measured using triphenyltetrazolium chloride staining. Short-term memory was evaluated using elevated plus maze. Inclined beam walking test was employed to assess motor incoordination. Bilateral carotid artery occlusion followed by reperfusion produced cerebral infarction and impaired short-term memory, motor co-ordination and lateral push response. A preceding episode of mesenteric artery occlusion for 15 min and reperfusion of 15 min (remote mesenteric ischaemic preconditioning) prevented markedly ischaemia-reperfusion-induced cerebral injury measured in terms of infarct size, loss of short-term memory, motor coordination and lateral push response. Glibenclamide (5 mg/kg, iv) a KATP channel blocker and caffeine (7 mg/kg, iv) an adenosine receptor blocker attenuated the neuroprotective effect of remote mesenteric ischaemic preconditioning. It may be concluded that neuroprotective effect of remote mesenteric ischaemic preconditioning may be due to activation of adenosine receptors and consequent activation of KATP channels in mice.

  6. Impact of recombinant globular adiponectin on early warm ischemia-reperfusion injury in rat bile duct after liver transplantation.

    Science.gov (United States)

    Xia, Yang; Gong, Jian-Ping

    2014-09-19

    Adiponectin (APN) is an adipocyte protein with anti-diabetic properties, which has been recently revealed to have anti-inflammatory activity in organ ischemia- reperfusion injury (IRI). However, little is known about its function in bile duct IRI after liver transplantation. Therefore, we investigated whether APN affects early warm IRI in rat bile duct using a liver autologous transplantation model. In our study, rats were randomly divided into three experimental groups: a sham group, a IRI group, and a APN group. The serum enzyme levels and BDISS scores of bile duct histology associated with bile duct injury, decreased after administration of APN. Subsequently, the expression of proinflammatory cytokines, such as tumor necrosis factor(TNF-α),.interleukin-6(IL-6) and myeloperoxidase (MPO) decreased. Furthermore, pretreatment with APN suppressed the activation of nuclear factor-kappa B (NF-κB) (p65), a transcription factor involved in inflammatory reactions, compared to other two groups. Administration of APN also downregulated the expression of Fas protein and attenuated caspase-3 activity to decrease bile duct apoptosis. Our results illustrate that APN protects the rat bile duct against early warm IRI by suppressing the inflammatory response and hepatocyte apoptosis, and NF-κB (p65) plays an important role in this process.

  7. Dynamics of markers of markers of acute kidney injury when using epidural block during resection under warm ischemia

    Directory of Open Access Journals (Sweden)

    O. I. Kit

    2017-01-01

    Full Text Available Objective: to investigate the time course of changes in the early biomarkers of acute kidney injury in patients with clinically localized cancer during partial nephrectomy, as electively indicated, under thermal ischemia with prior epidural block.Materials and methods. To analyze the nephroprotective effect of an epidural block in kidney resection with warm ischemia, markers of acute kidney injury (cystatin C, interleukin 18, NGAL, L-FABP and KIM-1 were studied by ELISA in the blood and urine of 35 patients with local cancer with an epidural block (main group and 37 patients with local cancer without an epidural block (control group before surgery and 40 min after its beginning and on days 1 and 3 of the postoperative period. All patients were divided into 2 groups by the levels of cystatin C in the blood serum: 1000 ng/ml and lower, and over 1000 ng/ml.Results. Epidural block during the perioperative period in kidney resection with warm ischemia for patients with local cancer had an obvious nephroprotective effect allowing maintaining the initial renal functional parameters, in contrast to the standard disease management.

  8. Beneficial effects of enteral nutrition containing with hydrolyzed whey peptide on warm ischemia/reperfusion injury in the rat liver.

    Science.gov (United States)

    Hanaoka, Jun; Shimada, Mitsuo; Utsunomiya, Toru; Morine, Yuji; Imura, Satoru; Ikemoto, Tetsuya; Mori, Hiroki; Sugimoto, Koji; Saito, Yu; Yamada, Shinichiro; Asanoma, Michihito

    2014-01-01

    This study examined the efficacy of enteral nutrition containing hydrolyzed whey peptide (HWP) on warm ischemia/reperfusion (I/R) injury in the rat liver. Male Wistar rats were subjected to 30 min of warm hepatic ischemia followed by immediate p.o. intake of enteral nutrition with WHP (HWP group) or 20% glucose solution (control group) (0.025 mL/g). The animals were killed at 6 or 12 h after reperfusion. The serum aspartate aminotransferase (AST) and alanine aminotransferase alt (ALT) levels were measured. The necrotic areas were assessed histologically. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining and caspase-3 activation were assessed to evaluate apoptosis. The expressions of hepatic tumor necrosis factor (TNF)-α, interleukin (IL)-6 and nuclear factor (NF)-κB in the liver tissue were assessed by real time reverse transcription polymerase chain reaction. Significant reductions in the serum AST and ALT levels were seen in the HWP group compared with the control group at both 6 and 12 h after reperfusion. The necrotic areas and numbers of TUNEL positive cells were significantly decreased in the HWP group at 6 and 12 h after reperfusion. The caspase-3/7 activities were significantly decreased in HWP group at 6 and 12 h after reperfusion. The mRNA expressions of TNF-α and IL-6 were significantly reduced in the HWP group at 12 h after reperfusion. NF-κB mRNA expression was significantly increased in the HWP group at 6 and 12 h after reperfusion. Enteral nutrition containing HWP ameliorated the hepatic warm I/R injury possibly through the suppression of pro-inflammatory cytokine expressions and the induction of NF-κB in the rat liver. © 2013 The Japan Society of Hepatology.

  9. Riboflavin (vitamin B-2) reduces hepatocellular injury following liver ischaemia and reperfusion in mice.

    Science.gov (United States)

    Sanches, Sheila Cristina; Ramalho, Leandra Naira Z; Mendes-Braz, Mariana; Terra, Vânia Aparecida; Cecchini, Rubens; Augusto, Marlei Josiele; Ramalho, Fernando Silva

    2014-05-01

    Riboflavin has been shown to exhibit anti-inflammatory and antioxidant properties in the settings of experimental sepsis and ischaemia/reperfusion (I/R) injury. We investigated the effect of riboflavin on normothermic liver I/R injury. Mice were submitted to 60 min of ischaemia plus saline or riboflavin treatment (30 μmoles/kg BW) followed by 6 h of reperfusion. Hepatocellular injury was evaluated by aminotransferase levels, reduced glutathione (GSH) content and the histological damage score. Hepatic neutrophil accumulation was assessed using the naphthol method and by measuring myeloperoxidase activity. Hepatic oxidative/nitrosative stress was estimated by immunohistochemistry. Liver endothelial and inducible nitric oxide synthase (eNOS/iNOS) and nitric oxide (NO) amounts were assessed by immunoblotting and a chemiluminescence assay. Riboflavin significantly reduced serum and histological parameters of hepatocellular damage, neutrophil infiltration and oxidative/nitrosative stress. Furthermore, riboflavin infusion partially recovered hepatic GSH reserves and decreased the liver contents of eNOS/iNOS and NO. These data indicate that riboflavin exerts antioxidant and anti-inflammatory effects in the ischaemic liver, protecting hepatocytes against I/R injury. The mechanism of these effects appears to be related to the intrinsic antioxidant potential of riboflavin/dihydroriboflavin and to reduced hepatic expression of eNOS/iNOS and reduced NO levels, culminating in attenuation of oxidative/nitrosative stress and the acute inflammatory response. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Cellular infiltrates and injury evaluation in a rat model of warm pulmonary ischemia-reperfusion

    NARCIS (Netherlands)

    Van Putte, BP; Kesecioglu, J; Hendriks, JMH; Persy, VP; van Marck, E; Van Schil, PEY; De Broe, ME

    Introduction Beside lung transplantation, cardiopulmonary bypass, isolated lung perfusion and sleeve resection result in serious pulmonary ischemia - reperfusion injury, clinically known as acute respiratory distress syndrome. Very little is known about cells infiltrating the lung during ischemia -

  11. Predicting renal recovery after liver transplant with severe pretransplant subacute kidney injury: The impact of warm ischemia time.

    Science.gov (United States)

    Laskey, Heather L; Schomaker, Nathan; Hung, Kenneth W; Asrani, Sumeet K; Jennings, Linda; Nydam, Trevor L; Gralla, Jane; Wiseman, Alex; Rosen, Hugo R; Biggins, Scott W

    2016-08-01

    Identifying which liver transplantation (LT) candidates with severe kidney injury will have a full recovery of renal function after liver transplantation alone (LTA) is difficult. Avoiding unnecessary simultaneous liver-kidney transplantation (SLKT) can optimize the use of scarce kidney grafts. Incorrect predictions of spontaneous renal recovery after LTA can lead to increased morbidity and mortality. We retrospectively analyzed all LTA patients at our institution from February 2002 to February 2013 (n = 583) and identified a cohort with severe subacute renal injury (n = 40; creatinine <2 mg/dL in the 14-89 days prior to LTA and not on renal replacement therapy [RRT] yet, ≥2 mg/dL within 14 days of LTA and/or on RRT). Of 40 LTA recipients, 26 (65%) had renal recovery and 14 (35%) did not. The median (interquartile range) warm ischemia time (WIT) in recipients with and without renal recovery after LTA was 31 minutes (24-46 minutes) and 39 minutes (34-49 minutes; P = 0.02), respectively. Adjusting for the severity of the subacute kidney injury with either Acute Kidney Injury Network or Risk, Injury, Failure, Loss, and End-Stage Kidney Disease criteria, increasing WIT was associated with lack of renal recovery (serum creatinine <2 mg/dL after LTA, not on RRT), with an odds ratio (OR) of 1.08 (1.01-1.16; P = 0.03) and 1.09 (1.01-1.17; P = 0.02), respectively. For each minute of increased WIT, there was an 8%-9% increase in the risk of lack of renal recovery after LTA. In a separate cohort of 98 LTA recipients with subacute kidney injury, we confirmed the association of WIT and lack of renal recovery (OR, 1.04; P = 0.04). In LT candidates with severe subacute renal injury, operative measures to minimize WIT may improve renal recovery potentially avoiding RRT and the need for subsequent kidney transplant. Liver Transplantation 22 1085-1091 2016 AASLD. © 2016 American Association for the Study of Liver Diseases.

  12. The effectiveness of neuromuscular warm-up strategies, that require no additional equipment, for preventing lower limb injuries during sports participation: a systematic review.

    Science.gov (United States)

    Herman, Katherine; Barton, Christian; Malliaras, Peter; Morrissey, Dylan

    2012-07-19

    Lower limb injuries in sport are increasingly prevalent and responsible for large economic as well as personal burdens. In this review we seek to determine which easily implemented functional neuromuscular warm-up strategies are effective in preventing lower limb injuries during sports participation and in which sporting groups they are effective. Seven electronic databases were searched from inception to January 2012 for studies investigating neuromuscular warm-up strategies and injury prevention. The quality of each included study was evaluated using a modified version of the van Tulder scale. Data were extracted from each study and used to calculate the risk of injury following application of each evaluated strategy. Nine studies were identified including six randomized controlled trials (RCT) and three controlled clinical trials (CCT). Heterogeneity in study design and warm-up strategies prevented pooling of results. Two studies investigated male and female participants, while the remaining seven investigated women only. Risk Ratio (RR) statistics indicated 'The 11+' prevention strategy significantly reduces overall (RR 0.67, confidence interval (CI) 0.54 to 0.84) and overuse (RR 0.45, CI 0.28 to 0.71) lower limb injuries as well as knee (RR 0.48, CI 0.32 to 0.72) injuries among young amateur female footballers. The 'Knee Injury Prevention Program' (KIPP) significantly reduced the risk of noncontact lower limb (RR 0.5, CI 0.33 to 0.76) and overuse (RR 0.44, CI 0.22 to 0.86) injuries in young amateur female football and basketball players. The 'Prevent Injury and Enhance Performance' (PEP) strategy reduces the incidence of anterior cruciate ligament (ACL) injuries (RR 0.18, CI 0.08 to 0.42). The 'HarmoKnee' programme reduces the risk of knee injuries (RR 0.22, CI 0.06 to 0.76) in teenage female footballers. The 'Anterior Knee Pain Prevention Training Programme' (AKP PTP) significantly reduces the incidence of anterior knee pain (RR 0.27, CI 0.14 to 0.54) in

  13. The effectiveness of neuromuscular warm-up strategies, that require no additional equipment, for preventing lower limb injuries during sports participation: a systematic review

    Directory of Open Access Journals (Sweden)

    Herman Katherine

    2012-07-01

    Full Text Available Abstract Background Lower limb injuries in sport are increasingly prevalent and responsible for large economic as well as personal burdens. In this review we seek to determine which easily implemented functional neuromuscular warm-up strategies are effective in preventing lower limb injuries during sports participation and in which sporting groups they are effective. Methods Seven electronic databases were searched from inception to January 2012 for studies investigating neuromuscular warm-up strategies and injury prevention. The quality of each included study was evaluated using a modified version of the van Tulder scale. Data were extracted from each study and used to calculate the risk of injury following application of each evaluated strategy. Results Nine studies were identified including six randomized controlled trials (RCT and three controlled clinical trials (CCT. Heterogeneity in study design and warm-up strategies prevented pooling of results. Two studies investigated male and female participants, while the remaining seven investigated women only. Risk Ratio (RR statistics indicated 'The 11+' prevention strategy significantly reduces overall (RR 0.67, confidence interval (CI 0.54 to 0.84 and overuse (RR 0.45, CI 0.28 to 0.71 lower limb injuries as well as knee (RR 0.48, CI 0.32 to 0.72 injuries among young amateur female footballers. The 'Knee Injury Prevention Program' (KIPP significantly reduced the risk of noncontact lower limb (RR 0.5, CI 0.33 to 0.76 and overuse (RR 0.44, CI 0.22 to 0.86 injuries in young amateur female football and basketball players. The 'Prevent Injury and Enhance Performance' (PEP strategy reduces the incidence of anterior cruciate ligament (ACL injuries (RR 0.18, CI 0.08 to 0.42. The 'HarmoKnee' programme reduces the risk of knee injuries (RR 0.22, CI 0.06 to 0.76 in teenage female footballers. The 'Anterior Knee Pain Prevention Training Programme' (AKP PTP significantly reduces the incidence of anterior

  14. A Multinational Cluster Randomised Controlled Trial to Assess the Efficacy of '11+ Kids': A Warm-Up Programme to Prevent Injuries in Children's Football.

    Science.gov (United States)

    Rössler, Roland; Junge, Astrid; Bizzini, Mario; Verhagen, Evert; Chomiak, Jiri; Aus der Fünten, Karen; Meyer, Tim; Dvorak, Jiri; Lichtenstein, Eric; Beaudouin, Florian; Faude, Oliver

    2018-06-01

    The objective of this study was to assess the efficacy of a newly developed warm-up programme ('11+ Kids') regarding its potential to reduce injuries in children's football. Children's football teams (under 9 years, under 11 years, and under 13 years age groups) from Switzerland, Germany, the Czech Republic and the Netherlands were invited. Clubs were randomised to an intervention group and a control group, and followed for one season. The intervention group replaced their usual warm-up by '11+ Kids', while the control group warmed up as usual. The primary outcome was the overall risk of football-related injuries. Secondary outcomes were the risks of severe and lower extremity injuries. We calculated hazard ratios using extended Cox models, and performed a compliance analysis. In total, 292,749 h of football exposure of 3895 players were recorded. The mean age of players was 10.8 (standard deviation 1.4) years. During the study period, 374 (intervention group = 139; control group = 235) injuries occurred. The overall injury rate in the intervention group was reduced by 48% compared with the control group (hazard ratio 0.52; 95% confidence interval 0.32-0.86). Severe (74% reduction, hazard ratio 0.26; 95% confidence interval 0.10-0.64) and lower extremity injuries (55% reduction, hazard ratio 0.45; 95% confidence interval 0.24-0.84) were also reduced. Injury incidence decreased with increasing compliance. '11+ Kids' is efficacious in reducing injuries in children's football. We observed considerable effects for overall, severe and lower extremity injuries. The programme should be performed at least once per week to profit from an injury preventive effect. However, two sessions per week can be recommended to further increase the protective benefit. ClinicalTrials.gov identifier: NCT02222025.

  15. The Role of Mitochondrial Reactive Oxygen Species in Cardiovascular Injury and Protective Strategies

    Directory of Open Access Journals (Sweden)

    Danina M. Muntean

    2016-01-01

    Full Text Available Ischaemia/reperfusion (I/R injury of the heart represents a major health burden mainly associated with acute coronary syndromes. While timely coronary reperfusion has become the established routine therapy in patients with ST-elevation myocardial infarction, the restoration of blood flow into the previously ischaemic area is always accompanied by myocardial injury. The central mechanism involved in this phenomenon is represented by the excessive generation of reactive oxygen species (ROS. Besides their harmful role when highly generated during early reperfusion, minimal ROS formation during ischaemia and/or at reperfusion is critical for the redox signaling of cardioprotection. In the past decades, mitochondria have emerged as the major source of ROS as well as a critical target for cardioprotective strategies at reperfusion. Mitochondria dysfunction associated with I/R myocardial injury is further described and ultimately analyzed with respect to its role as source of both deleterious and beneficial ROS. Furthermore, the contribution of ROS in the highly investigated field of conditioning strategies is analyzed. In the end, the vascular sources of mitochondria-derived ROS are briefly reviewed.

  16. The Relationship of Parental Warm Responsiveness and Negativity to Emerging Behavior Problems Following Traumatic Brain Injury in Young Children

    Science.gov (United States)

    Wade, Shari L.; Cassedy, Amy; Walz, Nicolay C.; Taylor, H. Gerry; Stancin, Terry; Yeates, Keith Owen

    2013-01-01

    Parenting behaviors play a critical role in the child's behavioral development, particularly for children with neurological deficits. This study examined the relationship of parental warm responsiveness and negativity to changes in behavior following traumatic brain injury (TBI) in young children relative to an age-matched cohort of children with orthopedic injuries (OI). It was hypothesized that responsive parenting would buffer the adverse effects of TBI on child behavior, whereas parental negativity would exacerbate these effects. Children, ages 3–7 years, hospitalized for TBI (n = 80) or OI (n = 113), were seen acutely and again 6 months later. Parent–child dyads were videotaped during free play. Parents completed behavior ratings (Child Behavior Checklist; T. M. Achenbach & L. A. Rescorla, 2001) at both visits, with baseline ratings reflecting preinjury behavior. Hypotheses were tested using multiple regression, with preinjury behavior ratings, race, income, child IQ, family functioning, and acute parental distress serving as covariates. Parental responsiveness and negativity had stronger associations with emerging externalizing behaviors and attention-deficit/hyperactivity disorder symptoms among children with severe TBI. Findings suggest that parenting quality may facilitate or impede behavioral recovery following early TBI. Interventions that increase positive parenting may partially ameliorate emerging behavior problems. PMID:21244154

  17. Epigenomic and transcriptomic approaches in the post-genomic era : Path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

    NARCIS (Netherlands)

    Perrino, Cinzia; Barabási, Albert Laszló; Condorelli, Gianluigi; Davidson, Sean Michael; De Windt, Leon J.; Dimmeler, Stefanie; Engel, Felix Benedikt; Hausenloy, Derek John; Hill, Joseph Addison; Van Laake, Linda Wilhelmina; Lecour, Sandrine; Leor, Jonathan; Madonna, Rosalinda; Mayr, Manuel; Prunier, Fabrice; Sluijter, Joost Petrus Geradus; Schulz, Rainer; Thum, Thomas; Ytrehus, Kirsti; Ferdinandy, Péter

    2017-01-01

    Despite advances in myocardial reperfusion therapies, acute myocardial ischaemia/reperfusion injury and consequent ischaemic heart failure represent the number one cause of morbidity and mortality in industrialized societies. Although different therapeutic interventions have been shown beneficial in

  18. Allowable warm ischemic time and morphological and biochemical changes in uterine ischemia/reperfusion injury in cynomolgus macaque: a basic study for uterus transplantation.

    Science.gov (United States)

    Kisu, Iori; Umene, Kiyoko; Adachi, Masataka; Emoto, Katsura; Nogami, Yuya; Banno, Kouji; Itagaki, Iori; Kawamoto, Ikuo; Nakagawa, Takahiro; Narita, Hayato; Yoshida, Atsushi; Tsuchiya, Hideaki; Ogasawara, Kazumasa; Aoki, Daisuke

    2017-10-01

    How long is the allowable warm ischemic time of the uterus and what morphological and biochemical changes are caused by uterine ischemia/reperfusion injury in cynomolgus macaques? Warm ischemia in the uterus of cynomolgus macaques is tolerated for up to 4 h and reperfusion after uterine ischemia caused no further morphological and biochemical changes. Uterus transplantation is a potential option for women with uterine factor infertility. The allowable warm ischemic time and ischemia/reperfusion injury of the uterus in humans and non-human primates is unknown. This experimental study included 18 female cynomolgus macaques with periodic menstruation. Animals were divided into six groups of three monkeys each: a control group and groups with uterine ischemia for 0.5, 1, 2, 4 and 8 h. Biopsies of uterine tissues were performed before blood flow blockage, after each blockage time, and after reperfusion for 3 h. Blood sampling was performed after each blockage time, and after reperfusion for 5, 15 and 30 min for measurement of biochemical data. Resumption of menstruation was monitored after the surgical procedure. Morphological, physiological and biochemical changes after ischemia and reperfusion were evaluated. Mild muscle degeneration and zonal degeneration were observed in all animals subjected to warm ischemia for 4 or 8 h, but there were no marked differences in the appearance of specimens immediately after ischemia and after reperfusion for 3 h in animals subjected to 4 or 8 h of warm ischemia. There were no significant changes in any biochemical parameters at any time point in each group. Periodical menstruation resumed in all animals with warm ischemia up to 4 h, but did not recover in animals with warm ischemia for 8 h with atrophic uteri. Warm ischemia in actual transplantation was not exactly mimicked in this study because uteri were not perfused, cooled, transplanted or reanastomosed with vessels. Results in non-human primates cannot always be extrapolated to

  19. Antioxidant effect of erdosteine and lipoic acid in ovarian ischemia-reperfusion injury.

    Science.gov (United States)

    Dokuyucu, R; Karateke, A; Gokce, H; Kurt, R K; Ozcan, O; Ozturk, S; Tas, Z A; Karateke, F; Duru, M

    2014-12-01

    To investigate the effects of erdosteine and alpha lipoic acid (ALA) in a rat model of ovarian ischaemia-reperfusion injury. Forty-eight female Wistar albino rats were separated, at random, into six groups of eight rats. The groups were classified as: sham, torsion, detorsion, detorsion+erdosteine 100mg/kg, detorsion+alpha lipoic acid (ALA) 100mg/kg, and detorsion+erdosteine+ALA. The investigators executing the biochemical and histological analyses were blinded to the randomization until the end of the study. The TOS (Total Oxidant Status) and OSI (Oxidative Stress Index) levels are higher in the Torsion and Detorsion groups when compared with the ones in the Sham group (pOSI and total histological score in the sham, torsion and detorsion groups (r=0.765, pOSI in the rats that received erdosteine and/or ALA were significantly lower compared with the sham, torsion and detorsion groups (pOSI were lower in the detorsion+erdosteine+ALA group compared with the detorsion+erdosteine and detorsion+ALA groups (pmodel; combination treatment had a greater effect than either agent alone. Treatment with erdosteine and/or ALA was found to preserve the loss of reproductive capacity normally observed after ovarian torsion. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  20. R1 autonomic nervous system in acute kidney injury.

    Science.gov (United States)

    Hering, Dagmara; Winklewski, Pawel J

    2017-02-01

    Acute kidney injury (AKI) is a rapid loss of kidney function resulting in accumulation of end metabolic products and associated abnormalities in fluid, electrolyte and acid-base homeostasis. The pathophysiology of AKI is complex and multifactorial involving numerous vascular, tubular and inflammatory pathways. Neurohumoral activation with heightened activity of the sympathetic nervous system and renin-angiotensin-aldosterone system play a critical role in this scenario. Inflammation and/or local renal ischaemia are underlying mechanisms triggering renal tissue hypoxia and resultant renal microcirculation dysfunction; a common feature of AKI occurring in numerous clinical conditions leading to a high morbidity and mortality rate. The contribution of renal nerves to the pathogenesis of AKI has been extensively demonstrated in a series of experimental models over the past decades. While this has led to better knowledge of the pathogenesis of human AKI, therapeutic approaches to improve patient outcomes are scarce. Restoration of autonomic regulatory function with vagal nerve stimulation resulting in anti-inflammatory effects and modulation of centrally-mediated mechanisms could be of clinical relevance. Evidence from experimental studies suggests that a therapeutic splenic ultrasound approach may prevent AKI via activation of the cholinergic anti-inflammatory pathway. This review briefly summarizes renal nerve anatomy, basic insights into neural control of renal function in the physiological state and the involvement of the autonomic nervous system in the pathophysiology of AKI chiefly due to sepsis, cardiopulmonary bypass and ischaemia/reperfusion experimental model. Finally, potentially preventive experimental pre-clinical approaches for the treatment of AKI aimed at sympathetic inhibition and/or parasympathetic stimulation are presented. © 2016 John Wiley & Sons Australia, Ltd.

  1. Protective effect of ebselen on experimental testicular torsion and detorsion injury.

    Science.gov (United States)

    Rifaioglu, M M; Motor, S; Davarci, I; Tuzcu, K; Sefil, F; Davarci, M; Nacar, A

    2014-12-01

    Ebselen is used as a drug in clinical trials against stroke, reperfusion injury with anti-atherosclerotic and renoprotective effects. The aim of this study is to investigate the protective effect of ebselen, on torsion/detorsion (T/D)-induced biochemical and histopathological changes in experimental testicular ischaemia/reperfusion injury. A total of 28 male Wistar Albino rats were divided into four groups: group 1(sham-operated group, n = 7), group 2(ebselen group, n = 7), group 3(torsion/detorsion + saline, n = 7) and group 4(T/D + 10 mg kg(-1) ebselen group, n = 7). The tissue homogenate samples were used for immediate nitric oxide (NO), malondialdehyde (MDA), superoxide dismutase, catalase and glutathione measurement. Testes in all groups were evaluated for the biochemical assay and histopathological examinations. To evaluate spermatogenesis, Johnsen scoring system was used. Testicular tissue MDA and NO levels in group 3 were significantly higher than in group 1 and 4. In histological evaluation of the testicular tissues, ebselen administration improved tubular histology significantly compared with T/D group. Significant increase in histological score was observed in the testis of group 3 compared with group 1 and 2. Histological score in group 4 significantly decreased compared with group 3. Johnson score was significantly lower in T/D group compared with all other three groups, ebselen administration increased the score significantly compared with T/D group. Ebselen reduced oxidative biochemical and histopathological damage in our testicular T/D rat model. © 2013 Blackwell Verlag GmbH.

  2. Mechanism of freeze-thaw injury and recovery: A cool retrospective and warming up to new ideas.

    Science.gov (United States)

    Arora, Rajeev

    2018-05-01

    Understanding cellular mechanism(s) of freeze-thaw injury (FTI) is key to the efforts for improving plant freeze-tolerance by cultural methods or molecular/genetic approaches. However, not much work has been done in the last 25+ years to advance our understanding of the nature and cellular loci of FTI. Currently, two FTI lesions are predominantly implicated: 1) structural and functional perturbations in plasma membrane; 2) ROS-induced oxidative damage. While both have stood the test of time, many questions remain unresolved and other potentially significant lesions need to be investigated. Additionally, molecular mechanism of post-thaw recovery (PTR), a critical component of frost-survival, has not been well investigated. Mechanistic understanding of repair after reversible injury could expand the options for strategies to improve frost-hardiness. In this review, without claiming to be exhaustive, I have attempted to synthesize major discoveries from last several decades on the mechanisms of FTI and the relatively little research conducted thus far on PTR mechanisms. It is followed by proposing of hypotheses for mechanism(s) for irreversible FTI or PTR involving cytosolic calcium and ROS signaling. Perspective is presented on some unresolved questions and research on new ideas to fill the knowledge gaps and advance the field. Copyright © 2018 Elsevier B.V. All rights reserved.

  3. Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.

    Directory of Open Access Journals (Sweden)

    Sevasti Zervou

    Full Text Available The creatine kinase (CK phosphagen system is fundamental to cellular energy homeostasis. Cardiomyocytes express three CK isoforms, namely the mitochondrial sarcomeric CKMT2 and the cytoplasmic CKM and CKB. We hypothesized that augmenting CK in vitro would preserve cell viability and function and sought to determine efficacy of the various isoforms. The open reading frame of each isoform was cloned into pcDNA3.1, followed by transfection and stable selection in human embryonic kidney cells (HEK293. CKMT2- CKM- and CKB-HEK293 cells had increased protein and total CK activity compared to non-transfected cells. Overexpressing any of the three CK isoforms reduced cell death in response to 18h hypoxia at 1% O2 followed by 2h re-oxygenation as assayed using propidium iodide: by 33% in CKMT2, 47% in CKM and 58% in CKB compared to non-transfected cells (P<0.05. Loading cells with creatine did not modify cell survival. Transient expression of CK isoforms in HL-1 cardiac cells elevated isoenzyme activity, but only CKMT2 over-expression protected against hypoxia (0.1% for 24h and reoxygenation demonstrating 25% less cell death compared to non-transfected control (P<0.01. The same cells were not protected from doxorubicin toxicity (250nM for 48h, in contrast to the positive control. These findings support increased CK activity as protection against ischaemia-reperfusion injury, in particular, protection via CKMT2 in a cardiac-relevant cell line, which merits further investigation in vivo.

  4. The 6-hydroxychromanol derivative SUL-109 ameliorates renal injury after deep hypothermia and rewarming in rats.

    Science.gov (United States)

    Vogelaar, Pieter C; Roorda, Maurits; de Vrij, Edwin L; Houwertjes, Martin C; Goris, Maaike; Bouma, Hjalmar; van der Graaf, Adrianus C; Krenning, Guido; Henning, Robert H

    2018-04-11

    Mitochondrial dysfunction plays an important role in kidney damage in various pathologies, including acute and chronic kidney injury and diabetic nephropathy. In addition to the well-studied ischaemia/reperfusion (I/R) injury, hypothermia/rewarming (H/R) also inflicts acute kidney injury. Substituted 6-hydroxychromanols are a novel class of mitochondrial medicines that ameliorate mitochondrial oxidative stress and protect the mitochondrial network. To identify a novel 6-hydroxychromanol that protects mitochondrial structure and function in the kidney during H/R, we screened multiple compounds in vitro and subsequently assessed the efficacy of the 6-hydroxychromanol derivatives SUL-109 and SUL-121 in vivo to protect against kidney injury after H/R in rats. Human proximal tubule cell viability was assessed following exposure to H/R for 48/4 h in the presence of various 6-hydroxychromanols. Selected compounds (SUL-109, SUL-121) or vehicle were administered to ketamine-anaesthetized male Wistar rats (IV 135 µg/kg/h) undergoing H/R at 15°C for 3 h followed by rewarming and normothermia for 1 h. Metabolic parameters and body temperature were measured throughout. In addition, renal function, renal injury, histopathology and mitochondrial fitness were assessed. H/R injury in vitro lowered cell viability by 94 ± 1%, which was counteracted dose-dependently by multiple 6-hydroxychomanols derivatives. In vivo, H/R in rats showed kidney injury molecule 1 expression in the kidney and tubular dilation, accompanied by double-strand DNA breaks and protein nitrosylation. SUL-109 and SUL-121 ameliorated tubular kidney damage, preserved mitochondrial mass and maintained cortical adenosine 5'-triphosphate (ATP) levels, although SUL-121 did not reduce protein nitrosylation. The substituted 6-hydroxychromanols SUL-109 and SUL-121 ameliorate kidney injury during in vivo H/R by preserving mitochondrial mass, function and ATP levels. In addition, both 6-hydroxychromanols

  5. Inhibition of warm ischemic injury to rat liver, pancreas, and heart grafts by controlling the nutritional status of both donor and recipient.

    Science.gov (United States)

    Nishihara, V; Sumimoto, R; Fukuda, Y; Southard, J H; Asahara, T; Dohi, K

    1997-01-01

    In this study, we tested the effect of donor fasting with or without the use of an essential fatty acids deficiency (EFAD) diet in the recipient using rat heart, pancreas, and liver transplant models. We then compared the survivals, tumor necrosis factor alpha (TNF-alpha) response, and white cell accumulation in rats in order to clarify the mechanisms of the beneficial effect of donor fasting and recipient EFAD. It was found that when the grafts were obtained from fasted donors and then transplanted into fed recipients, the survival rate was significantly higher for all three grafts than for those obtained from fed rats and transplanted into fed rats. The best survival was seen for pancreas grafts obtained from fasted donors and then transplanted into EFAD recipients. TNF-alpha secretion was significantly suppressed in both fasted and EFAD rats, and both the total cell count and neutrophil count were suppressed in EFAD rats. These results clearly indicate that in addition to liver grafts, both heart and pancreas grafts obtained from fasted animals are more tolerant to warm ischemic injury. Furthermore, the combination of donor fasting and recipient EFAD acts synergistically to inhibit the post-transplantation inflammatory reaction (through decreased TNF-alpha secretion and white cell accumulation), thus resulting in an improved survival.

  6. Global warming

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    Canada's Green Plan strategy for dealing with global warming is being implemented as a multidepartmental partnership involving all Canadians and the international community. Many of the elements of this strategy are built on an existing base of activities predating the Green Plan. Elements of the strategy include programs to limit emissions of greenhouse gases, such as initiatives to encourage more energy-efficient practices and development of alternate fuel sources; studies and policy developments to help Canadians prepare and adapt to climate change; research on the global warming phenomenon; and stimulation of international action on global warming, including obligations arising out of the Framework Convention on Climate Change. All the program elements have been approved, funded, and announced. Major achievements to date are summarized, including improvements in the Energy Efficiency Act, studies on the socioeconomic impacts of global warming, and participation in monitoring networks. Milestones associated with the remaining global warming initiatives are listed

  7. Timely Diagnosis of Acute Kidney Injury Using Kinetic eGFR and the Creatinine Excretion to Production Ratio, E/eG - Creatinine Can Be Useful!

    Science.gov (United States)

    Endre, Zoltán H; Pianta, Timothy J; Pickering, John W

    2016-01-01

    Post transplant repeated measurements of urine volume and serum creatinine (sCr) are used to assess kidney function. Under non-steady state conditions, repeated measurement of sCr allows calculation of the kinetic estimated GFR (KeGFR). Additional measurement of urinary creatinine allows the calculation of the creatinine excretion to (estimated) production ratio (E/eG). We hypothesized that post-transplant KeGFR and E/eG would predict delayed graft function (DGF), as early as 4 h and outperform a validated clinical model at 12 h. This was a retrospective analysis of prospectively acquired data in a study of 56 recipients of deceased-donor kidney transplant. We assessed predictive performance with the area under the receiver operator characteristic curve (AUC) and the added value to a clinical model with integrated discrimination improvement analysis. At 4 h, the AUC for E/eG was 0.87 (95% CI 0.77-0.96) and for KeGFR 0.69 (95% CI 0.56-0.83). Both E/eG and KeGFR improved the risk prediction of a clinical model for DGF by 32 and 18%, and for non-DGF by 17 and 10%, respectively. While E/eG had better predictive performance of DGF than KeGFR, KeGFR might also facilitate perioperative management including drug dosing after kidney transplantation. Together these measurements may facilitate the possibility of conducting trials of early intervention to ameliorate the adverse effects of ischaemia-reperfusion injury on long-term DGF. © 2016 S. Karger AG, Basel.

  8. Effect of black tea consumption on brachial artery flow-mediated dilation and ischaemia-reperfusion in humans.

    NARCIS (Netherlands)

    Schreuder, T.H.A.; Eijsvogels, T.M.H.; Greyling, A.; Draijer, R.; Hopman, M.T.E.; Thijssen, D.H.J.

    2014-01-01

    Tea consumption is associated with reduced cardiovascular risk. Previous studies found that tea flavonoids work through direct effects on the vasculature, leading to dose-dependent improvements in endothelial function. Cardioprotective effects of regular tea consumption may relate to the prevention

  9. Global warming

    International Nuclear Information System (INIS)

    Houghton, John

    2005-01-01

    'Global warming' is a phrase that refers to the effect on the climate of human activities, in particular the burning of fossil fuels (coal, oil and gas) and large-scale deforestation, which cause emissions to the atmosphere of large amounts of 'greenhouse gases', of which the most important is carbon dioxide. Such gases absorb infrared radiation emitted by the Earth's surface and act as blankets over the surface keeping it warmer than it would otherwise be. Associated with this warming are changes of climate. The basic science of the 'greenhouse effect' that leads to the warming is well understood. More detailed understanding relies on numerical models of the climate that integrate the basic dynamical and physical equations describing the complete climate system. Many of the likely characteristics of the resulting changes in climate (such as more frequent heat waves, increases in rainfall, increase in frequency and intensity of many extreme climate events) can be identified. Substantial uncertainties remain in knowledge of some of the feedbacks within the climate system (that affect the overall magnitude of change) and in much of the detail of likely regional change. Because of its negative impacts on human communities (including for instance substantial sea-level rise) and on ecosystems, global warming is the most important environmental problem the world faces. Adaptation to the inevitable impacts and mitigation to reduce their magnitude are both necessary. International action is being taken by the world's scientific and political communities. Because of the need for urgent action, the greatest challenge is to move rapidly to much increased energy efficiency and to non-fossil-fuel energy sources

  10. Preconditioning with Azadirachta indica ameliorates cardiorenal dysfunction through reduction in oxidative stress and extracellular signal regulated protein kinase signalling

    Directory of Open Access Journals (Sweden)

    Temidayo Olutayo Omóbòwálé

    2016-10-01

    Conclusions: Together, A. indica and vitamin C prevented IRI-induced cardiorenal dysfunction via reduction in oxidative stress, improvement in antioxidant defence system and increase in the ERK1/2 expressions. Therefore, A. indica can be a useful chemopreventive agent in the prevention and treatment of conditions associated with intestinal ischaemia-reperfusion injury.

  11. Browse Title Index

    African Journals Online (AJOL)

    Items 201 - 250 of 643 ... Vol 7, No 2 (2004), Effect of soya bean diet preparations on some ... Vol 20, No 3 (2017), Effects of diets containing unripe plantain diet on brain serotonin ... of Intestinal Ischaemia-Reperfusion Injury and Splenectomy on ...

  12. The concept of anaesthetic-induced cardioprotection: mechanisms of action

    NARCIS (Netherlands)

    Weber, Nina C.; Schlack, Wolfgang

    2005-01-01

    The mechanisms by which ischaemia reperfusion injury can be influenced have been the subject of extensive research in the last decades. Early restoration of arterial blood flow and surgical measures to improve the ischaemic tolerance of the tissue are the main therapeutic options currently in

  13. Hepatic regeneration and functional recovery following partial liver resection in an experimental model of hepatic steatosis treated with omega-3 fatty acids

    NARCIS (Netherlands)

    Marsman, H. A.; de Graaf, W.; Heger, M.; van Golen, R. F.; ten Kate, F. J. W.; Bennink, R.; van Gulik, T. M.

    2013-01-01

    Omega-3 fatty acids (FAs) have been shown to reduce experimental hepatic steatosis and protect the liver from ischaemia-reperfusion injury. The aim of this study was to examine the effects of omega-3 FAs on regeneration of steatotic liver. Steatosis was induced in rats by a 3-week

  14. Global warming

    CERN Document Server

    Hulme, M

    1998-01-01

    Global warming-like deforestation, the ozone hole and the loss of species- has become one of the late 20the century icons of global environmental damage. The threat, is not the reality, of such a global climate change has motivated governments. businesses and environmental organisations, to take serious action ot try and achieve serious control of the future climate. This culminated last December in Kyoto in the agreement for legally-binding climate protocol. In this series of three lectures I will provide a perspective on the phenomenon of global warming that accepts the scientific basis for our concern, but one that also recognises the dynamic interaction between climate and society that has always exited The future will be no different. The challenge of global warning is not to pretend it is not happening (as with some pressure groups), nor to pretend it threatens global civilisation (as with other pressure groups), and it is not even a challenge to try and stop it from happening-we are too far down the ro...

  15. Multifactorial Biological Modulation of Warm Ischemia Reperfusion Injury in Liver Transplantation From Non-Heart-Beating Donors Eliminates Primary Nonfunction and Reduces Bile Salt Toxicity

    NARCIS (Netherlands)

    Monbaliu, Diethard; Vekemans, Katrien; Hoekstra, Harm; Vaahtera, Lauri; Libbrecht, Louis; Derveaux, Katelijne; Parkkinen, Jaakko; Liu, Qiang; Heedfeld, Veerle; Wylin, Tine; Deckx, Hugo; Zeegers, Marcel; Balligand, Erika; Buurman, Wim; van Pelt, Jos; Porte, Robert J.; Pirenne, Jacques

    Objective: To design a multifactorial biological modulation approach targeting ischemia reperfusion injury to augment viability of porcine liver grafts from non-heart-beating donors (NHBD). Background Data: Liver Transplantation (LTx) from NHBD is associated with an increased risk of primary

  16. Pretreatment of liver grafts in vivo by γ-aminobutyric acid receptor regulation reduces cold ischemia/warm reperfusion injury in rat

    Science.gov (United States)

    Hori, Tomohide; Gardner, Lindsay B.; Hata, Toshiyuki; Chen, Feng; Baine, Ann-Marie T.; Uemoto, Shinji; Nguyen, Justin H.

    2014-01-01

    Summary Background: Gamma-aminobutyric acid (GABA) is found throughout the body. The regulation of GABA receptor (GABAR) reduces oxidative stress (OS). Ischemia/reperfusion injury after orthotopic liver transplantation (OLT) causes OS-induced graft damage. The effects of GABAR regulation in donors in vivo were investigated. Material/Methods: Donor rats received saline, a GABAR agonist or GABAR antagonist 4 h before surgery. Recipient rats were divided into four groups according to the donor treatments: laparotomy, OLT with saline, OLT with GABAR agonist and OLT with GABAR antagonist. Histopathological, biochemical and immunohistological examinations were performed at 6, 12 and 24 h after OLT. Protein assays were performed at 6 h after OLT. The 4-hydroxynonenal (4-HNE), ataxia-telangiectasia mutated kinase (ATM), phosphorylated histone H2AX (γH2AX), phosphatidylinositol-3 kinase (PI3K), Akt and superoxide dismutase (SOD) were assessed by western blot analysis. Results: In the univariate analysis, histopathological and biochemical profiles verified that the GABAR agonist reduced graft damage. Immunohistology revealed that the GABAR agonist prevented the induction of apoptosis. Measurement of 4-4-HNE levels confirmed OS-induced damage after OLT, and the GABAR agonist improved this damage. In the γH2AX, PI3K, Akt and antioxidant enzymes (SODs), ATM and H2AX were greatly increased after OLT, and were reduced by the GABAR agonist. In the multivariate analyses between multiple groups, histopathological assessment, aspartate aminotransferase level, immunohistological examinations for apoptotic induction and γH2AX showed statistical differences. Conclusions: A specific agonist demonstrated regulation of GABAR in vivo in the liver. This activation in vivo reduced OS after OLT via the ATM/H2AX pathway. PMID:23792534

  17. Sudden Stratospheric Warming Compendium

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Sudden Stratospheric Warming Compendium (SSWC) data set documents the stratospheric, tropospheric, and surface climate impacts of sudden stratospheric warmings. This...

  18. Cold injuries.

    Science.gov (United States)

    Kruse, R J

    1995-01-01

    There are two categories of cold injury. The first is hypothermia, which is a systemic injury to cold, and the second is frostbite, which is a local injury. Throughout history, entire armies, from George Washington to the Germans on the Russian Front in World War II, have fallen prey to prolonged cold exposure. Cold injury is common and can occur in all seasons if ambient temperature is lower than the core body temperature. In the 1985 Boston Marathon, even though it was 76 degrees and sunny, there were 75 runners treated for hypothermia. In general, humans adapt poorly to cold exposure. Children are at particular risk because of their relatively greater surface area/body mass ratio, causing them to cool even more rapidly than adults. Because of this, the human's best defense against cold injury is to limit his/her exposure to cold and to dress appropriately. If cold injury has occurred and is mild, often simple passive rewarming such as dry blankets and a warm room are sufficient treatment.

  19. Warm Mix Asphalt

    Science.gov (United States)

    2009-04-17

    State of Alaska State of Alaska - Warm Mix Project Warm Mix Project: Location - Petersburg, Alaska which is Petersburg, Alaska which is located in the heart of Southeast Alaska located in the heart of Southeast Alaska's Inside Passage at the tip of M...

  20. Warm fresh whole blood and thoracic traumain iraq and afghanistan.

    Science.gov (United States)

    Keneally, Ryan J; Parsons, Andrew M; Willett, Peter B

    2015-01-01

    Thoracic trauma occurred in 10% of the patients seen at US military treatment facilities in Iraq and Afghanistan and 52% of those patients were transfused. Among those transfused, 281 patients received warm fresh whole blood. A previous report documented improved survival with warm fresh whole blood in patients injured in combat without stratification by injury pattern. A later report described an increase in acute lung injuries after its administration. Survivorship and warm fresh whole blood have never been analyzed in a subpopulation at highest risk for lung injuries, such as patients with thoracic trauma. There may be a heterogeneous relationship between whole blood and survival based on likelihood of a concomitant pulmonary injury. In this report, the relationship between warm fresh whole blood and survivorship was analyzed among patients at highest risk for concomitant pulmonary injuries. Patients with thoracic trauma who received a transfusion were identified in the Joint Theater Trauma Registry. Gross mortality rates were compared between whole blood recipients and patients transfused with component therapy only. The association between each blood component and mortality was determined in a regression model. The overall mortality risk was compared between warm fresh whole blood recipients and non-recipients. Patients transfused with warm fresh whole blood in addition to component therapy had a higher mortality rate than patients transfused only separated blood components (21.3% vs. 12.8%, P warm fresh whole blood in addition to component therapy was not associated with increased mortality risk compared with the transfusion of component therapy only (OR 1.247 [95% CI 0.760-2.048], P = 0.382). Patients with combat related thoracic trauma transfused with warm fresh whole blood were not at increased risk for mortality compared to those who received component therapy alone when controlling for covariates.

  1. Pre-ischemic mitochondrial substrate constraint by inhibition of malate-aspartate shuttle preserves mitochondrial function after ischemia-reperfusion

    DEFF Research Database (Denmark)

    Jespersen, Nichlas Riise; Yokota, Takashi; Støttrup, Nicolaj Brejnholt

    2017-01-01

    KEY POINTS: Pre-ischaemic administration of aminooxiacetate (AOA), an inhibitor of the malate-aspartate shuttle (MAS), provides cardioprotection against ischaemia-reperfusion injury. The underlying mechanism remains unknown. We examined whether transient inhibition of the MAS during ischaemia......, but not IPC, reduced the myocardial interstitial concentration of tricarboxylic acid cycle intermediates at the onset of reperfusion. The results obtained in the present study demonstrate that metabolic regulation by inhibition of the MAS at the onset of reperfusion may be beneficial for the preservation...... of mitochondrial function during late reperfusion in an IR-injured heart. ABSTRACT: Mitochondrial dysfunction plays a central role in ischaemia-reperfusion (IR) injury. Pre-ischaemic administration of aminooxyacetate (AOA), an inhibitor of the malate-aspartate shuttle (MAS), provides cardioprotection against IR...

  2. Nitric oxide : An ally in extracorporeal circulation?

    OpenAIRE

    Melki, Vilyam

    2016-01-01

    Many complications associated with heart surgery are due to the negative effects of extracorporeal circulation (ECC). Some of these complications may be attributed to ECC-induced activation of inflammation and coagulation pathways. The inflammatory reaction may be caused by the interaction of blood components with air and the artificial surfaces of the ECC, from substances produced due to ischaemia-reperfusion injury of the heart and lungs, and from increased release of endotoxin from ischemi...

  3. Global Warming: A Myth?

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 6; Issue 7. Global Warming: A Myth? - Credibility of Climate Scenarios Predicted by Systems Simulations. Deepanjan Majumdar. General Article Volume 6 Issue 7 July 2001 pp 13-21 ...

  4. Warm and Cool Dinosaurs.

    Science.gov (United States)

    Mannlein, Sally

    2001-01-01

    Presents an art activity in which first grade students draw dinosaurs in order to learn about the concept of warm and cool colors. Explains how the activity also helped the students learn about the concept of distance when drawing. (CMK)

  5. Global warming yearbook: 1998

    Energy Technology Data Exchange (ETDEWEB)

    Arris, L. [ed.

    1999-02-01

    The report brings together a year`s worth of global warming stories - over 280 in all - in one convenient volume. It provides a one-stop report on the scientific, political and industrial implications of global warming. The report includes: detailed coverage of negotiations on the Kyoto Protocol; scientific findings on carbon sources and sinks, coral bleaching, Antarctic ice shelves, plankton, wildlife and tree growth; new developments on fuel economy, wind power, fuel cells, cogeneration, energy labelling and emissions trading.

  6. Media Pembelajaran Global Warming

    OpenAIRE

    Tham, Fikri Jufri; Liliana, Liliana; Purba, Kristo Radion

    2016-01-01

    Computer based learning media is one of the media has an important role in learning. Learning media will be attractive when packaged through interactive media , such as interactive media created in paper manufacture " instructional media global warming" . The advantage gained is that it can increase knowledge, generally educate people to be more concerned about the environment , and also can be a means of entertainment. This application is focused to learn about global warming and packaged in...

  7. Refrigeration and global warming

    International Nuclear Information System (INIS)

    Anon.

    1997-01-01

    Some aspects of global warming in general, and the implications for refrigerants and refrigerator efficiency in particular, are briefly considered in a question and answer format. The concepts of Global Warming Potential (GWP) and Total Equivalent Warming Impact (TEWI) are explained. GWP is an index which allows a simple comparison to be make between the warming effects of different gases on a kg to kg basis relative to carbon. The GWP depends both on the lifetime of a substance in the atmosphere and its infra-red absorption capacity. The overall warming effect of operating a refrigeration system for its entire life is measured by its TEWI. Chloroflourocarbons (CFCs) which have been widely used as refrigerants are powerful greenhouse gases with high GWPs. Because of the bank of CFCs in refrigerating systems, their levels in the atmosphere are still increasing and it will be some time before refrigerant changes will be effective in reducing the warming effects of refrigerant releases. Hydrocarbons, hydroflourocarbons and ammonia all have a part to play as substitute refrigerants. Refrigerator efficiency is very important in terms of reducing CO 2 emissions. (UK)

  8. Retinal vascular injuries and intravitreal human embryonic stem cell-derived haemangioblasts.

    Science.gov (United States)

    Wang, Jin-Da; An, Ying; Zhang, Jing-Shang; Wan, Xiu-Hua; Zhang, Wei; Lanza, Robert; Lu, Shi-Jiang; Jonas, Jost B; Xu, Liang

    2017-09-01

    To investigate whether intravitreally applied haemangioblasts (HB) derived from human embryonic stem cells (hESCs) are helpful for the repair of vascular damage caused in animals by an oxygen-induced retinopathy (OIR), by an induced diabetic retinopathy (DR) or by an induced retinal ischaemia with subsequent reperfusion. Human embryonic stem cell-derived HBs were transplanted intravitreally into C57BL/6J mice (OIR model), into male Wistar rats with an induced DR and into male Wistar rats undergoing induced retinal ischaemia with subsequent reperfusion. Control groups of animals received an intravitreal injection of endothelial cells (ECs) or phosphate-buffered saline (PBS). We examined the vasculature integrity in the mice with OIR, the blood-retina barrier in the rats with induced DR, and retinal thickness and retinal ganglion cell density in retina flat mounts of the rats with the retinal ischaemic-reperfusion retinopathy. In the OIR model, the study group versus control groups showed a significantly (p < 0.001) smaller retinal avascular area [5.1 ± 2.7%;n = 18 animals versus 12.2 ± 2.8% (PBS group; n = 10 animals) and versus 11.8 ± 3.7% (EC group; n = 8 animals)] and less retinal neovascularization [6.3 ± 2.5%;n = 18 versus 15.2 ± 6.3% (n = 10; PBS group) and versus 15.8 ± 3.3% (n = 8; EC group)]. On retinal flat mounts, hESC-HBs were integrated into damaged retinal vessels and stained positive for PECAM (CD31) as EC marker. In the DR model, the study group versus the EC control group showed a significantly (p = 0.001) better blood-retina barrier function as measured at 2 days after the intravitreal injections [study group: 20.2 ± 12.8 μl/(g × hr); n = 6; versus EC control group: 52.9 ± 9.9 μl/(g × hr; n = 6)]. In the retinal ischaemia-reperfusion model, the groups did not differ significantly in retinal thickness and retinal ganglion cell density at 2, 5 and 7 days after baseline. By integrating into

  9. Global warming on trial

    International Nuclear Information System (INIS)

    Broeker, W.S.

    1992-01-01

    Jim Hansen, a climatologist at NASA's Goddard Space Institute, is convinced that the earth's temperature is rising and places the blame on the buildup of greenhouse gases in the atmosphere. Unconvinced, John Sununu, former White House chief of staff, doubts that the warming will be great enough to produce serious threat and fears that measures to reduce the emissions would throw a wrench into the gears that drive the Unites States' troubled economy. During his three years at the White House, Sununu's view prevailed, and although his role in the debate has diminished, others continue to cast doubt on the reality of global warming. A new lobbying group called the Climate Council has been created to do just this. Burning fossil fuels is not the only problem; a fifth of emissions of carbon dioxide now come from clearing and burning forests. Scientists are also tracking a host of other greenhouse gases that emanate from a variety of human activities; the warming effect of methane, chlorofluorocarbons and nitrous oxide combined equals that of carbon dioxide. Although the current warming from these gases may be difficult to detect against the background noise of natural climate variation, most climatologists are certain that as the gases continue to accumulate, increases in the earth's temperature will become evident even to skeptics. If the reality of global warming were put on trial, each side would have trouble making its case. Jim Hansen's side could not prove beyond a reasonable doubt that carbon dioxide and other greenhouse gases have warmed the planet. But neither could John Sununu's side prove beyond a reasonable doubt that the warming expected from greenhouse gases has not occurred. To see why each side would have difficulty proving its case, this article reviews the arguments that might be presented in such a hearing

  10. Long range global warming

    International Nuclear Information System (INIS)

    Rolle, K.C.; Pulkrabek, W.W.; Fiedler, R.A.

    1995-01-01

    This paper explores one of the causes of global warming that is often overlooked, the direct heating of the environment by engineering systems. Most research and studies of global warming concentrate on the modification that is occurring to atmospheric air as a result of pollution gases being added by various systems; i.e., refrigerants, nitrogen oxides, ozone, hydrocarbons, halon, and others. This modification affects the thermal radiation balance between earth, sun and space, resulting in a decrease of radiation outflow and a slow rise in the earth's steady state temperature. For this reason the solution to the problem is perceived as one of cleaning up the processes and effluents that are discharged into the environment. In this paper arguments are presented that suggest, that there is a far more serious cause for global warming that will manifest itself in the next two or three centuries; direct heating from the exponential growth of energy usage by humankind. Because this is a minor contributor to the global warming problem at present, it is overlooked or ignored. Energy use from the combustion of fuels and from the output of nuclear reactions eventually is manifest as warming of the surroundings. Thus, as energy is used at an ever increasing rate the consequent global warming also increases at an ever increasing rate. Eventually this rate will become equal to a few percent of solar radiation. When this happens the earth's temperature will have risen by several degrees with catastrophic results. The trends in world energy use are reviewed and some mathematical models are presented to suggest future scenarios. These models can be used to predict when the global warming problem will become undeniably apparent, when it will become critical, and when it will become catastrophic

  11. G-warm inflation

    Energy Technology Data Exchange (ETDEWEB)

    Herrera, Ramón, E-mail: ramon.herrera@pucv.cl [Instituto de Física, Pontificia Universidad Católica de Valparaíso, Avenida Brasil 2950, Casilla 4059, Valparaíso (Chile)

    2017-05-01

    A warm inflationary universe in the context of Galileon model or G-model is studied. Under a general formalism we study the inflationary dynamics and the cosmological perturbations considering a coupling of the form G (φ, X )= g (φ) X . As a concrete example, we consider an exponential potential together with the cases in which the dissipation and Galilean coefficients are constants. Also, we study the weak regime given by the condition R <1+3 gH φ-dot , and the strong regime in which 1< R +3 gH φ-dot . Additionally, we obtain constraints on the parameters during the evolution of G-warm inflation, assuming the condition for warm inflation in which the temperature T > H , the conditions or the weak and strong regimes, together with the consistency relation r = r ( n {sub s} ) from Planck data.

  12. G-warm inflation

    Science.gov (United States)

    Herrera, Ramón

    2017-05-01

    A warm inflationary universe in the context of Galileon model or G-model is studied. Under a general formalism we study the inflationary dynamics and the cosmological perturbations considering a coupling of the form G(phi,X)=g(phi) X. As a concrete example, we consider an exponential potential together with the cases in which the dissipation and Galilean coefficients are constants. Also, we study the weak regime given by the condition RR+3gHdot phi. Additionally, we obtain constraints on the parameters during the evolution of G-warm inflation, assuming the condition for warm inflation in which the temperature T>H, the conditions or the weak and strong regimes, together with the consistency relation r=r(ns) from Planck data.

  13. The global warming problem

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    In this chapter, a discussion is presented of the global warming problem and activities contributing to the formation of acid rain, urban smog and to the depletion of the ozone layer. Globally, about two-thirds of anthropogenic carbon dioxide emissions arise from fossil-fuel burning; the rest arise primarily from deforestation. Chlorofluorocarbons are the second largest contributor to global warming, accounting for about 20% of the total. The third largest contributor is methane, followed by ozone and nitrous oxide. A study of current activities in the US that contribute to global warming shows the following: electric power plants account for about 33% of carbon dioxide emissions; motor vehicles, planes and ships (31%); industrial plants (24%); commercial and residential buildings (11%)

  14. Greenhouse Warming Research

    DEFF Research Database (Denmark)

    Sørensen, Bent Erik

    2016-01-01

    The changing greenhouse effect caused by natural and anthropogenic causes is explained and efforts to model the behavior of the near-surface constituents of the Earth's land, ocean and atmosphere are discussed. Emissions of various substances and other aspects of human activity influence...... the greenhouse warming, and the impacts of the warming may again impact the wellbeing of human societies. Thus physical modeling of the near-surface ocean-soil-atmosphere system cannot be carried out without an idea of the development of human activities, which is done by scenario analysis. The interactive...

  15. Warm pre-stressing

    International Nuclear Information System (INIS)

    Hedner, G.

    1983-01-01

    Literature survey and critical evaluation of the phenomenon of warm pre-stressing (WPS) is presented. It is found that the cause of it is not clear and a calculated control is missing. The effect of irradiation is unknown, and the influence of WPS on the behaviour of reactor vessels is discussed. (G.B.)

  16. Being Warm-Hearted

    Institute of Scientific and Technical Information of China (English)

    李函; 任汉鼎

    2017-01-01

    Good morning,ladies and gentlemen.It’s my honor to address[向……致辞] you.My English name is Isabella.I’m a high school student of 17.I have some good personality traits[特点],including being warm-hearted.So here comes my topic:Being

  17. Warm and Cool Cityscapes

    Science.gov (United States)

    Jubelirer, Shelly

    2012-01-01

    Painting cityscapes is a great way to teach first-grade students about warm and cool colors. Before the painting begins, the author and her class have an in-depth discussion about big cities and what types of buildings or structures that might be seen in them. They talk about large apartment and condo buildings, skyscrapers, art museums,…

  18. The global warming scare

    International Nuclear Information System (INIS)

    Sunavala, P.D.

    1992-01-01

    It is argued that the present propaganda about the global warming with its disastrous consequences is a scare spread by some First World countries, especially the United States, to prevent the rapid industrialization of developing third world countries. (author). 6 refs., 1 tab

  19. Paralyzed warming world

    Czech Academy of Sciences Publication Activity Database

    Ač, Alexander

    2010-01-01

    Roč. 2, č. 2 (2010), s. 81-86 ISSN 1876-8156 Institutional research plan: CEZ:AV0Z60870520 Keywords : global warming * climate Subject RIV: EH - Ecology, Behaviour http://ojs.ubvu.vu.nl/alf/article/view/134/250

  20. Reconstructing warm inflation

    Science.gov (United States)

    Herrera, Ramón

    2018-03-01

    The reconstruction of a warm inflationary universe model from the scalar spectral index n_S(N) and the tensor to scalar ratio r( N) as a function of the number of e-folds N is studied. Under a general formalism we find the effective potential and the dissipative coefficient in terms of the cosmological parameters n_S and r considering the weak and strong dissipative stages under the slow roll approximation. As a specific example, we study the attractors for the index n_S given by nS-1∝ N^{-1} and for the ratio r∝ N^{-2}, in order to reconstruct the model of warm inflation. Here, expressions for the effective potential V(φ ) and the dissipation coefficient Γ (φ ) are obtained.

  1. Thinking About Global Warming

    International Nuclear Information System (INIS)

    Baron, J.

    2006-01-01

    Attitudes toward global warming are influenced by various heuristics, which may distort policy away from what is optimal for the well-being of people. These possible distortions, or biases, include: a focus on harms that we cause, as opposed to those that we can remedy more easily; a feeling that those who cause a problem should fix it; a desire to undo a problem rather than compensate for its presence; parochial concern with one's own group (nation); and neglect of risks that are not available. Although most of these biases tend to make us attend relatively too much to global warming, other biases, such as wishful thinking, cause us to attend too little. I discuss these possible effects and illustrate some of them with an experiment conducted on the World Wide Web

  2. Climate change - global warming

    International Nuclear Information System (INIS)

    Ciconkov, Risto

    2001-01-01

    An explanation about climate, weather, climate changes. What is a greenhouse effect, i.e. global warming and reasons which contribute to this effect. Greenhouse gases (GHG) and GWP (Global Warming Potential) as a factor for estimating their influence on the greenhouse effect. Indicators of the climate changes in the previous period by known international institutions, higher concentrations of global average temperature. Projecting of likely scenarios for the future climate changes and consequences of them on the environment and human activities: industry, energy, agriculture, water resources. The main points of the Kyoto Protocol and problems in its realization. The need of preparing a country strategy concerning the acts of the Kyoto Protocol, suggestions which could contribute in the preparation of the strategy. A special attention is pointed to the energy, its resources, the structure of energy consumption and the energy efficiency. (Author)

  3. Warm natural inflation

    International Nuclear Information System (INIS)

    Mishra, Hiranmaya; Mohanty, Subhendra; Nautiyal, Akhilesh

    2012-01-01

    In warm inflation models there is the requirement of generating large dissipative couplings of the inflaton with radiation, while at the same time, not de-stabilising the flatness of the inflaton potential due to radiative corrections. One way to achieve this without fine tuning unrelated couplings is by supersymmetry. In this Letter we show that if the inflaton and other light fields are pseudo-Nambu-Goldstone bosons then the radiative corrections to the potential are suppressed and the thermal corrections are small as long as the temperature is below the symmetry breaking scale. In such models it is possible to fulfil the contrary requirements of an inflaton potential which is stable under radiative corrections and the generation of a large dissipative coupling of the inflaton field with other light fields. We construct a warm inflation model which gives the observed CMB-anisotropy amplitude and spectral index where the symmetry breaking is at the GUT scale.

  4. Slowing global warming

    International Nuclear Information System (INIS)

    Flavin, C.

    1990-01-01

    According to the authors, global warming promises to be one of the central environmental issues of the nineties. After a decade of scientific concern but popular neglect, the eighties ended with a growing political as well as scientific consensus that the world can no longer afford to procrastinate about this issue. This paper reports on coping with global warming which, according to the author, will force societies to move rapidly into uncharted terrain, reversing powerful trends that have dominated the industrial age. This challenge cannot be met without a strong commitment on the part of both individual consumers and governments. In terms of the earth's carbon balance, the unprecedented policy changes that have now become urgent include a new commitment to greater energy efficiency and renewable energy sources, a carbon tax on fossil fuels, a reversal of deforestation in tropical countries, and the rapid elimination of CFCs

  5. Military Implications of Global Warming.

    Science.gov (United States)

    1999-05-20

    U.S. environmental issues also have important global implications. This paper analyzes current U.S. Policy as it pertains to global warming and climate...for military involvement to reduce global warming . Global warming and other environmental issues are important to the U.S. military. As the United

  6. EFFECTS OF GLOBAL WARMING

    OpenAIRE

    Dr. Basanti Jain

    2017-01-01

    The abnormal increase in the concentration of the greenhouse gases is resulting in higher temperatures. We call this effect is global warming. The average temperature around the world has increased about 1'c over 140 years, 75% of this has risen just over the past 30 years. The solar radiation, as it reaches the earth, produces "greenhouse effect" in the atmosphere. The thick atmospheric layers over the earth behaves as a glass surface, as it permits short wave radiations from coming in, but ...

  7. Mesoamerican Nephropathy or Global Warming Nephropathy?

    Science.gov (United States)

    Roncal-Jimenez, Carlos A; García-Trabanino, Ramon; Wesseling, Catharina; Johnson, Richard J

    2016-01-01

    An epidemic of chronic kidney disease (CKD) of unknown cause has emerged along the Pacific Coast of Central America. The disease primarily affects men working manually outdoors, and the major group affected is sugarcane workers. The disease presents with an asymptomatic rise in serum creatinine that progresses to end-stage renal disease over several years. Renal biopsies show chronic tubulointerstitial disease. While the cause remains unknown, recent studies suggest that it is driven by recurrent dehydration in the hot climate. Potential mechanisms include the development of hyperosmolarity with the activation of the aldose reductase-fructokinase pathway in the proximal tubule leading to local injury and inflammation, and the possibility that renal injury may be the consequence of repeated uricosuria and urate crystal formation as a consequence of both increased generation and urinary concentration, similar to a chronic tumor lysis syndrome. The epidemic is postulated to be increasing due to the effects of global warming. An epidemic of CKD has led to the death of more than 20,000 lives in Central America. The cause is unknown, but appears to be due to recurrent dehydration. Potential mechanisms for injury are renal damage as a consequence of recurrent hyperosmolarity and/or injury to the tubules from repeated episodes of uricosuria. The epidemic of CKD in Mesoamerica may be due to chronic recurrent dehydration as a consequence of global warming and working conditions. This entity may be one of the first major diseases attributed to climate change and the greenhouse effect. © 2016 S. Karger AG, Basel.

  8. Warm natural inflation

    International Nuclear Information System (INIS)

    Mishra, Hiranmaya; Mohanty, Subhendra; Nautiyal, Akhilesh

    2013-01-01

    In warm inflation models there is the requirement of generating large dissipative couplings of the inflation with radiation, while at the same Âătime, not de-stabilising the flatness of the inflation potential due to radiative corrections. One way to achieve this without fine tuning unrelated couplings is by supersymmetry. In this talk we will discuss warm inflation with Pseudo-Nambu-Goldstone Bosons (PNGB). In this case inflation and other light fields are PNGB. So, the radiative corrections to the potential are suppressed and the thermal Âăcorrections are small as long as the temperature is below the symmetry breaking scale. In such models it is possible to fulfill the contrary requirements of an inflation potential which is stable under radiative corrections and the generation of a large dissipative coupling of the inflation field with other light fields. This warm inflation model with PNGB gives the observed CMB-anisotropy amplitude and spectral index having the symmetry breaking scale at the GUT scale. (author)

  9. Global warning, global warming

    International Nuclear Information System (INIS)

    Benarde, M.A.

    1992-01-01

    This book provides insights into the formidable array of issues which, in a warmer world, could impinge upon every facet of readers lives. It examines climatic change and long-term implications of global warming for the ecosystem. Topics include the ozone layer and how it works; the greenhouse effect; the dangers of imbalance and its effects on human and animal life; disruptions to the basic ecology of the planet; and the real scientific evidence for and against aberrant climatic shifts. The author also examines workable social and political programs and changes that must be instituted to avoid ecological disaster

  10. Global Warming: A Reduced Threat?.

    Science.gov (United States)

    Michaels, Patrick J.; Stooksbury, David E.

    1992-10-01

    One popular and apocalyptic vision of the world influenced by increasing concentrations of infrared-absorbing trace gases is that of ecological disaster brought about by rapidly rising temperatures, sea level, and evaporation rates. This vision developed from a suite of climate models that have since considerably changed in both their dynamics and their estimates of prospective warming. Observed temperatures indicate that much more warming should already have taken place than predicted by earlier models in the Northern Hemisphere, and that night, rather than day, readings in that hemisphere show a relative warming. A high-latitude polar-night warming or a general night warming could be either benign or beneficial. A large number of plant species show both increased growth and greater water-use efficiency under enhanced carbon dioxide.An extensive body of evidence now indicates that anthropo-generated sulfate emissions are mitigating some of the warming, and that increased cloudiness as a result of these emissions will further enhance night, rather than day, warming. The sulfate emissions, though, are not sufficient to explain all of the night warming. However, the sensitivity of climate to anthropogenerated aerosols, and the general lack of previously predicted warming, could drastically alter the debate on global warming in favor of less expensive policies.

  11. Antarctica: Cooling or Warming?

    Science.gov (United States)

    Bunde, Armin; Ludescher, Josef; Franzke, Christian

    2013-04-01

    We consider the 14 longest instrumental monthly mean temperature records from the Antarctica and analyse their correlation properties by wavelet and detrended fluctuation analysis. We show that the stations in the western and the eastern part of the Antarctica show significant long-term memory governed by Hurst exponents close to 0.8 and 0.65, respectively. In contrast, the temperature records at the inner part of the continent (South Pole and Vostok), resemble white noise. We use linear regression to estimate the respective temperature differences in the records per decade (i) for the annual data, (ii) for the summer and (iii) for the winter season. Using a recent approach by Lennartz and Bunde [1] we estimate the respective probabilities that these temperature differences can be exceeded naturally without inferring an external (anthropogenic) trend. We find that the warming in the western part of the continent and the cooling at the South Pole is due to a gradually changes in the cold extremes. For the winter months, both cooling and warming are well outside the 95 percent confidence interval, pointing to an anthropogenic origin. In the eastern Antarctica, the temperature increases and decreases are modest and well within the 95 percent confidence interval. [1] S. Lennartz and A. Bunde, Phys. Rev. E 84, 021129 (2011)

  12. Daytime warming has stronger negative effects on soil nematodes than night-time warming

    OpenAIRE

    Yan, Xiumin; Wang, Kehong; Song, Lihong; Wang, Xuefeng; Wu, Donghui

    2017-01-01

    Warming of the climate system is unequivocal, that is, stronger warming during night-time than during daytime. Here we focus on how soil nematodes respond to the current asymmetric warming. A field infrared heating experiment was performed in the western of the Songnen Plain, Northeast China. Three warming modes, i.e. daytime warming, night-time warming and diurnal warming, were taken to perform the asymmetric warming condition. Our results showed that the daytime and diurnal warming treatmen...

  13. Global Warming on Triton

    Science.gov (United States)

    Elliot, J. L.; Hammel, H. B.; Wasserman, L. H.; Franz, O. G.; McDonald, S. W.; Person, M. J.; Olkin, C. B.; Dunham, E. J.; Spencer, J. R.; Stansberry, J. A.; hide

    1998-01-01

    Triton, Neptune's largest moon, has been predicted to undergo significant seasonal changes that would reveal themselves as changes in its mean frost temperature. But whether this temperature should at the present time be increasing, decreasing or constant depends on a number of parameters (such as the thermal properties of the surface, and frost migration patterns) that are unknown. Here we report observations of a recent stellar occultation by Triton which, when combined with earlier results, show that Triton has undergone a period of global warming since 1989. Our most conservative estimates of the rate of temperature and surface-pressure increase during this period imply that the atmosphere is doubling in bulk every 10 years, significantly faster than predicted by any published frost model for Triton. Our result suggests that permanent polar caps on Triton play a c dominant role in regulating seasonal atmospheric changes. Similar processes should also be active on Pluto.

  14. Structure of Warm Nuclei

    International Nuclear Information System (INIS)

    Aaberg, S.; Uhrenholt, H.

    2009-01-01

    We study the structure of nuclei in the energy region between the ground state and the neutron separation energy, here called warm nuclei. The onset of chaos in the nucleus as excitation energy is increased is briefly reviewed. Chaos implies fluctuations of energies and wave functions qualitatively the same for all chaotic nuclei. On the other hand, large structure effects are seen, e.g. in the level-density function at same excitation energies. A microscopic model for the level density is reviewed and we discuss effects on structure of the total level-density function, parity enhancement, and the spin distribution function. Comparisons to data are performed at the neutron separation energy for all observed nuclei, and structure of the level-density function for a few measured cases. The role of structure effects in the level-density function for fission dynamics is exemplified.

  15. Interacting warm dark matter

    International Nuclear Information System (INIS)

    Cruz, Norman; Palma, Guillermo; Zambrano, David; Avelino, Arturo

    2013-01-01

    We explore a cosmological model composed by a dark matter fluid interacting with a dark energy fluid. The interaction term has the non-linear λρ m α ρ e β form, where ρ m and ρ e are the energy densities of the dark matter and dark energy, respectively. The parameters α and β are in principle not constrained to take any particular values, and were estimated from observations. We perform an analytical study of the evolution equations, finding the fixed points and their stability properties in order to characterize suitable physical regions in the phase space of the dark matter and dark energy densities. The constants (λ,α,β) as well as w m and w e of the EoS of dark matter and dark energy respectively, were estimated using the cosmological observations of the type Ia supernovae and the Hubble expansion rate H(z) data sets. We find that the best estimated values for the free parameters of the model correspond to a warm dark matter interacting with a phantom dark energy component, with a well goodness-of-fit to data. However, using the Bayesian Information Criterion (BIC) we find that this model is overcame by a warm dark matter – phantom dark energy model without interaction, as well as by the ΛCDM model. We find also a large dispersion on the best estimated values of the (λ,α,β) parameters, so even if we are not able to set strong constraints on their values, given the goodness-of-fit to data of the model, we find that a large variety of theirs values are well compatible with the observational data used

  16. Local warming: daily temperature change influences belief in global warming.

    Science.gov (United States)

    Li, Ye; Johnson, Eric J; Zaval, Lisa

    2011-04-01

    Although people are quite aware of global warming, their beliefs about it may be malleable; specifically, their beliefs may be constructed in response to questions about global warming. Beliefs may reflect irrelevant but salient information, such as the current day's temperature. This replacement of a more complex, less easily accessed judgment with a simple, more accessible one is known as attribute substitution. In three studies, we asked residents of the United States and Australia to report their opinions about global warming and whether the temperature on the day of the study was warmer or cooler than usual. Respondents who thought that day was warmer than usual believed more in and had greater concern about global warming than did respondents who thought that day was colder than usual. They also donated more money to a global-warming charity if they thought that day seemed warmer than usual. We used instrumental variable regression to rule out some alternative explanations.

  17. The challenge of global warming

    International Nuclear Information System (INIS)

    Bryner, G.C.

    1992-01-01

    The chapter outlines the science of global warming, the likely consequences of global warming and some of the major challenges in dealing with global climate change. Some of the major international organisations concerned with environmental issues are listed. International agreements might be used to limit emissions of greenhouse gases. 32 refs., 2 tabs

  18. Global warming and prairie wetlands

    International Nuclear Information System (INIS)

    Poiani, K.A.; Johnson, W.C.

    1991-01-01

    In this article, the authors discuss current understanding and projections of global warming; review wetland vegetation dynamics to establish the strong relationship among climate, wetland hydrology, vegetation patterns and waterfowl habitat; discuss the potential effects of a greenhouse warming on these relationships; and illustrate the potential effects of climate change on wetland habitat by using a simulation model

  19. Warm Bodies: A Student Perspective.

    Science.gov (United States)

    Schario, Tracy A.

    A participant in forensic tournament competition presents her perspective as well as overall student reaction to the function of "warm bodies," competitors who are entered in a tournament by the coach or tournament director only to meet qualifying requirements. Overall, participants in an informal survey believed that the warm body…

  20. Comparison of the WarmCloud and Bair Hugger Warming Devices for the Prevention of Intraoperative Hypothermia in Patients Undergoing Orthotopic Liver Transplantation: A Randomized Clinical Trial

    Science.gov (United States)

    Pearce, Brett; Mattheyse, Linda; Ellard, Louise; Desmond, Fiona; Pillai, Param; Weinberg, Laurence

    2018-01-01

    Background The avoidance of hypothermia is vital during prolonged and open surgery to improve patient outcomes. Hypothermia is particularly common during orthotopic liver transplantation (OLT) and associated with undesirable physiological effects that can adversely impact on perioperative morbidity. The KanMed WarmCloud (Bromma, Sweden) is a revolutionary, closed-loop, warm-air heating mattress developed to maintain normothermia and prevent pressure sores during major surgery. The clinical effectiveness of the WarmCloud device during OLT is unknown. Therefore, we conducted a randomized controlled trial to determine whether the WarmCloud device reduces hypothermia and prevents pressure injuries compared with the Bair Hugger underbody warming device. Methods Patients were randomly allocated to receive either the WarmCloud or Bair Hugger warming device. Both groups also received other routine standardized multimodal thermoregulatory strategies. Temperatures were recorded by nasopharyngeal temperature probe at set time points during surgery. The primary endpoint was nasopharyngeal temperature recorded 5 minutes before reperfusion. Secondary endpoints included changes in temperature over the predefined intraoperative time points, number of patients whose nadir temperature was below 35.5°C and the development of pressure injuries during surgery. Results Twenty-six patients were recruited with 13 patients randomized to each group. One patient from the WarmCloud group was excluded because of a protocol violation. Baseline characteristics were similar. The mean (standard deviation) temperature before reperfusion was 36.0°C (0.7) in the WarmCloud group versus 36.3°C (0.6) in the Bairhugger group (P = 0.25). There were no statistical differences between the groups for any of the secondary endpoints. Conclusions When combined with standardized multimodal thermoregulatory strategies, the WarmCloud device does not reduce hypothermia compared with the Bair Hugger device in

  1. Forests and global warming

    International Nuclear Information System (INIS)

    Curren, T.

    1991-04-01

    The importance of forests to Canada, both in economic and environmental terms, is indisputable. A warmer global climate may well have profound effects on the Canadian boreal forest, and at least some of the effects will not be beneficial. With the state of the current knowledge of climate processes and climate change it is not possible to predict the extent or rate of projected changes of anthropogenic origin. Given these uncertainties, the appropriate course of action for the Canadian forest sector is to develop policies and strategies which will make good sense under the current climatic regime, and which will also be appropriate for actions in a warmer climate scenario. The business as usual approach is not acceptable in the context of pollution control as it has become clear that anthropogenic emissions of greenhouse gases and other pollutants must be substantially reduced, both to prevent (or at least slow the rate of) possible global warming, and to reduce impacts on the biophysical environment and human health. Effective mitigative actions must be introduced on both a national and global scale. Forest management policies more effectively geared to the sustainability of forests are needed. The programs that are developed out of such policies must be cognizant of the real possibility that climate in the present boreal forest regions may change in the near future. 13 refs

  2. Recent warming of lake Kivu.

    Science.gov (United States)

    Katsev, Sergei; Aaberg, Arthur A; Crowe, Sean A; Hecky, Robert E

    2014-01-01

    Lake Kivu in East Africa has gained notoriety for its prodigious amounts of dissolved methane and dangers of limnic eruption. Being meromictic, it is also expected to accumulate heat due to rising regional air temperatures. To investigate the warming trend and distinguish between atmospheric and geothermal heating sources, we compiled historical temperature data, performed measurements with logging instruments, and simulated heat propagation. We also performed isotopic analyses of water from the lake's main basin and isolated Kabuno Bay. The results reveal that the lake surface is warming at the rate of 0.12°C per decade, which matches the warming rates in other East African lakes. Temperatures increase throughout the entire water column. Though warming is strongest near the surface, warming rates in the deep waters cannot be accounted for solely by propagation of atmospheric heat at presently assumed rates of vertical mixing. Unless the transport rates are significantly higher than presently believed, this indicates significant contributions from subterranean heat sources. Temperature time series in the deep monimolimnion suggest evidence of convection. The progressive deepening of the depth of temperature minimum in the water column is expected to accelerate the warming in deeper waters. The warming trend, however, is unlikely to strongly affect the physical stability of the lake, which depends primarily on salinity gradient.

  3. Recent warming of lake Kivu.

    Directory of Open Access Journals (Sweden)

    Sergei Katsev

    Full Text Available Lake Kivu in East Africa has gained notoriety for its prodigious amounts of dissolved methane and dangers of limnic eruption. Being meromictic, it is also expected to accumulate heat due to rising regional air temperatures. To investigate the warming trend and distinguish between atmospheric and geothermal heating sources, we compiled historical temperature data, performed measurements with logging instruments, and simulated heat propagation. We also performed isotopic analyses of water from the lake's main basin and isolated Kabuno Bay. The results reveal that the lake surface is warming at the rate of 0.12°C per decade, which matches the warming rates in other East African lakes. Temperatures increase throughout the entire water column. Though warming is strongest near the surface, warming rates in the deep waters cannot be accounted for solely by propagation of atmospheric heat at presently assumed rates of vertical mixing. Unless the transport rates are significantly higher than presently believed, this indicates significant contributions from subterranean heat sources. Temperature time series in the deep monimolimnion suggest evidence of convection. The progressive deepening of the depth of temperature minimum in the water column is expected to accelerate the warming in deeper waters. The warming trend, however, is unlikely to strongly affect the physical stability of the lake, which depends primarily on salinity gradient.

  4. Global warming: the complete briefing

    Energy Technology Data Exchange (ETDEWEB)

    Houghton, J

    1994-01-01

    The science of global warming, its impacts, and what action might be taken, are described in this book, in a way which the intelligent non-scientist can understand. It also examines ethical and moral issues of concern about global warming, considering mankind as stewards of the earth. Chapter headings of the book are: global warming and climate change; the greenhouse effect; the greenhouse gases; climates of the past; modelling the climate; climate change and business-as-usual; the impacts of climate change; why should we be concerned ; weighing the uncertainty; action to slow and stabilize climate change; energy and transport for the future; and the global village.

  5. Amplified Arctic warming by phytoplankton under greenhouse warming.

    Science.gov (United States)

    Park, Jong-Yeon; Kug, Jong-Seong; Bader, Jürgen; Rolph, Rebecca; Kwon, Minho

    2015-05-12

    Phytoplankton have attracted increasing attention in climate science due to their impacts on climate systems. A new generation of climate models can now provide estimates of future climate change, considering the biological feedbacks through the development of the coupled physical-ecosystem model. Here we present the geophysical impact of phytoplankton, which is often overlooked in future climate projections. A suite of future warming experiments using a fully coupled ocean-atmosphere model that interacts with a marine ecosystem model reveals that the future phytoplankton change influenced by greenhouse warming can amplify Arctic surface warming considerably. The warming-induced sea ice melting and the corresponding increase in shortwave radiation penetrating into the ocean both result in a longer phytoplankton growing season in the Arctic. In turn, the increase in Arctic phytoplankton warms the ocean surface layer through direct biological heating, triggering additional positive feedbacks in the Arctic, and consequently intensifying the Arctic warming further. Our results establish the presence of marine phytoplankton as an important potential driver of the future Arctic climate changes.

  6. Fewer bacteria in warm water

    International Nuclear Information System (INIS)

    Bagh, Lene

    1999-01-01

    There has been many suggestions to how the ideal warm water system should be. Particularly whether warm water containers or heat exchangers in larger houses are the best solutions in order to maintain a water quality with low levels of bacteria. In an investigation made by Statens Byggeforskningsinstitutt (Denmark) regarding ''Bacterial growth in warm water installations with heat exchangers'' there were used several heat exchangers made by Gjelsted and Lund of three of which had HWAT heating cables. The bacterial content was low from these exchangers compared to exchangers with circulation. The article presents promising results from a study where the method was investigated over a longer period in two new larger warm water systems. Some energy conservation aspects are discussed

  7. Warm mix asphalt : final report.

    Science.gov (United States)

    2014-11-01

    The performance of pavements constructed using warm mix asphalt (WMA) technology were : compared to the performance of conventional hot mix asphalt (HMA) pavements placed on the : same project. Measurements of friction resistance, rutting/wear, ride ...

  8. Authropogenic Warming in North Alaska?.

    Science.gov (United States)

    Michaels, Patrick J.; Sappington, David E.; Stooksbury, David E.

    1988-09-01

    Using permafrost boreholes, Lachenbruch and Marshall recently reported evidence for a 2°-4°C warming in North Alaska occurring at some undetermined time during the last century. Popular accounts suggest their findings are evidence for anthropogenic warming caused by trace gases. Analyses of North Alaskan 1000-500 mb thickness onwards back to 1948 indicate that the warming was prior to that date. Relatively sparse thermometric data for the early twentieth century from Jones et al. are too noisy to support any trend since the data record begins in 1910, or to apply to any subperiod of climatic significance. Any warming detected from the permafrost record therefore occurred before the major emissions of thermally active trace gases.

  9. Global warming and nuclear power

    International Nuclear Information System (INIS)

    Hodgson, P.E.

    1999-01-01

    The problems of pollution, global warming and renewable energy sources are not going to go away. Governments need to act with urgency if they are to produce a long-term energy policy. This paper looks at the current energy situation, and how this would project into the future without the instigation of radical changes. It concludes that nuclear is the best option available for averting a growing energy, pollution and global warming crisis. (author)

  10. Global warming: A vicious circle

    International Nuclear Information System (INIS)

    Sinclair, J.

    1991-01-01

    As a result of increasing atmospheric concentrations of greenhouse gases the planet is already committed to regional droughts, storms, disruption of fisheries and the extinction of many plant and animal species. But current predictions of global warming do not take into account the reactions and interactions of the planet's land, ocean and ice masses to the rise in temperatures. It seems likely that the greenhouse effect will give rise to positive feedback reactions, leading to greater global warming than predicted

  11. Sphingosine-1-phosphate signalling induces the production of Lcn-2 by macrophages to promote kidney regeneration

    DEFF Research Database (Denmark)

    Sola, Anna; Weigert, Andreas; Jung, Michaela

    2011-01-01

    the kidney. The present study describes a mechanism for renal tissue regeneration after ischaemia/reperfusion injury. Following injury, apoptotic cell-derived sphingosine-1-phosphate (S1P) or exogenously administered sphingosine analogue FTY720 activates macrophages to support the proliferation and healing...... of renal epithelium, once inflammatory conditions are terminated. Both suppression of inflammation and renal regeneration might require S1P receptor 3 (S1P3) signalling and downstream release of neutrophil gelatinase-associated lipocalin (NGAL/Lcn-2) from macrophages. Overall, our data point...

  12. Sports Injuries

    Science.gov (United States)

    ... sometimes you can injure yourself when you play sports or exercise. Accidents, poor training practices, or improper ... can also lead to injuries. The most common sports injuries are Sprains and strains Knee injuries Swollen ...

  13. Golf Injuries

    Science.gov (United States)

    ... Our Newsletter Donate Blog Skip breadcrumb navigation Preventing Golf Injuries Golf looks like an easy game to ... WHAT TYPES OF INJURIES ARE MOST COMMON IN GOLF? Acute injuries are usually the result of a ...

  14. Unexpected Impacts of Global warming on Extreme Warm Spells

    Science.gov (United States)

    Sardeshmukh, P. D.; Compo, G. P.; McColl, C.; Penland, C.

    2017-12-01

    It is generally presumed that the likelihood of extreme warm spells around the globe has increased, and will continue to increase, due to global warming. However, we find that this is generally not true in three very different types of global observational datasets and uncoupled atmospheric model simulations of the 1959 to 2012 period with prescribed observed global SSTs, sea ice, and radiative forcing changes. While extreme warm spells indeed became more common in many regions, in many other regions their likelihood remained almost the same or even decreased from the first half to the second half of this period. Such regions of unexpected changes covered nearly 40 percent of the globe in both winter and summer. The basic reason for this was a decrease of temperature variability in such regions that offset or even negated the effect of the mean temperature shift on extreme warm spell probabilities. The possibility of such an impact on extreme value probabilities was highlighted in a recent paper by Sardeshmukh, Compo, and Penland (Journal of Climate 2015). The consistency of the changes in extreme warm spell probabilities among the different observational datasets and model simulations examined suggests that they are robust regional aspects of global warming associated with atmospheric circulation changes. This highlights the need for climate models to represent not just the mean regional temperature signals but also the changes in subseasonal temperature variability associated with global warming. However, current climate models (both CMIP3 and CMIP5) generally underestimate the magnitude of the changes in the atmospheric circulation and associated temperature variability. A likely major cause of this is their continuing underestimation of the magnitude of the spatial variation of tropical SST trends. By generating an overly spatially bland tropical SST warming in response to changes in radiative forcing, the models spuriously mute tropically

  15. The Great Warming Brian Fagan

    Science.gov (United States)

    Fagan, B. M.

    2010-12-01

    The Great Warming is a journey back to the world of a thousand years ago, to the Medieval Warm Period. Five centuries of irregular warming from 800 to 1250 had beneficial effects in Europe and the North Atlantic, but brought prolonged droughts to much of the Americas and lands affected by the South Asian monsoon. The book describes these impacts of warming on medieval European societies, as well as the Norse and the Inuit of the far north, then analyzes the impact of harsh, lengthy droughts on hunting societies in western North America and the Ancestral Pueblo farmers of Chaco Canyon, New Mexico. These peoples reacted to drought by relocating entire communities. The Maya civilization was much more vulnerable that small-scale hunter-gatherer societies and subsistence farmers in North America. Maya rulers created huge water storage facilities, but their civilization partially collapsed under the stress of repeated multiyear droughts, while the Chimu lords of coastal Peru adapted with sophisticated irrigation works. The climatic villain was prolonged, cool La Niñalike conditions in the Pacific, which caused droughts from Venezuela to East Asia, and as far west as East Africa. The Great Warming argues that the warm centuries brought savage drought to much of humanity, from China to Peru. It also argues that drought is one of the most dangerous elements in today’s humanly created global warming, often ignored by preoccupied commentators, but with the potential to cause over a billion people to starve. Finally, I use the book to discuss the issues and problems of communicating multidisciplinary science to the general public.

  16. Active Movement Warm-Up Routines

    Science.gov (United States)

    Walter, Teri; Quint, Ashleigh; Fischer, Kim; Kiger, Joy

    2011-01-01

    This article presents warm-ups that are designed to physiologically and psychologically prepare students for vigorous physical activity. An active movement warm-up routine is made up of three parts: (1) active warm-up movement exercises, (2) general preparation, and (3) the energy system. These warm-up routines can be used with all grade levels…

  17. How warm days increase belief in global warming

    Science.gov (United States)

    Zaval, Lisa; Keenan, Elizabeth A.; Johnson, Eric J.; Weber, Elke U.

    2014-02-01

    Climate change judgements can depend on whether today seems warmer or colder than usual, termed the local warming effect. Although previous research has demonstrated that this effect occurs, studies have yet to explain why or how temperature abnormalities influence global warming attitudes. A better understanding of the underlying psychology of this effect can help explain the public's reaction to climate change and inform approaches used to communicate the phenomenon. Across five studies, we find evidence of attribute substitution, whereby individuals use less relevant but available information (for example, today's temperature) in place of more diagnostic but less accessible information (for example, global climate change patterns) when making judgements. Moreover, we rule out alternative hypotheses involving climate change labelling and lay mental models. Ultimately, we show that present temperature abnormalities are given undue weight and lead to an overestimation of the frequency of similar past events, thereby increasing belief in and concern for global warming.

  18. Warm measurements of CBA superconducting magnets

    International Nuclear Information System (INIS)

    Engelmann, R.; Herrera, J.; Kahn, S.; Kirk, H.; Willen, E.; Yamin, P.

    1983-01-01

    We present results on magnetic field measurements of CBA dipole magnets in the warm (normal conductor) and cryogenic (superconducting) states. We apply two methods for the warm measurements, a dc and ac method. We find a good correlation between warm and cryogenic measurements which lends itself to a reliable diagnosis of magnet field errors using warm measurements early in the magnet assembly process. We further find good agreement between the two warm measurement methods, both done at low currents

  19. Peranan Environmental Accounting Terhadap Global Warming

    OpenAIRE

    Martusa, Riki

    2009-01-01

    This article explores about is global warming. The distortion of nature causes global warming. Industrial sector is one of global warming incurred. Some nations create a group to cope this matter. They try to reduce carbon emission as one of global warming causes by controlling industrial carbon emission through financial reporting. This article explores normatively roles of environmental accounting in cope with global warming.  

  20. The politics of global warming

    International Nuclear Information System (INIS)

    Moss, N.

    1991-01-01

    The probable warming of the world over the next few decades due to human activity presents a unique threat. The threat of global warming has been brought about by the activities of the entire human race, and only action by a large part of the human race can slow down the process or halt it. Other unwanted effects of industrial activity are trans-national, and require international agreements to regulate them, most obviously radioactivity from nuclear power accidents, acid rain and river pollution; but climatic change, unlike these, is global. International negotiations are going on now to deal with the problem of global warming, mostly by reducing the emission of gases that contribute to it. These are preliminary, yet already different perceptions and conflicting interests are emerging. The aim of the present negotiations is a convention for the UN Conference on Environment and Development (UNCED) to be held in June 1992, the so-called ''Earth Summit''. (author)

  1. Efficiency, sustainability and global warming

    International Nuclear Information System (INIS)

    Woodward, Richard T.; Bishop, Richard C.

    1995-01-01

    Economic analyses of global warming have typically been grounded in the theory of economic efficiency. Such analyses may be inappropriate because many of the underlying concerns about climate change are rooted not in efficiency, but in the intergenerational allocation of economic endowments. A simple economic model is developed which demonstrates that an efficient economy is not necessarily a sustainable economy. This result leads directly to questions about the policy relevance of several economic studies of the issue. We then consider policy alternatives to address global warming in the context of economies with the dual objectives of efficiency and sustainability, with particular attention to carbon-based taxes

  2. Global Warming: Physics and Facts

    International Nuclear Information System (INIS)

    Levi, B.G.; Hafemeister, D.; Scribner, R.

    1992-01-01

    This report contains papers on: A tutorial on global atmospheric energetics and the greenhouse effect; global climate models: what and how; comparison of general circulation models; climate and the earth's radiation budget; temperature and sea level change; short-term climate variability and predictions; the great ocean conveyor; trace gases in the atmosphere: temporal and spatial trends; the geochemical carbon cycle and the uptake of fossil fuel CO 2 ; forestry and global warming; the physical and policy linkages; policy implications of greenhouse warming; options for lowering US carbon dioxide emissions; options for reducing carbon dioxide emissions; and science and diplomacy: a new partnership to protect the environment

  3. Effects of different re-warm up activities in football players' performance.

    Directory of Open Access Journals (Sweden)

    Eduardo Abade

    Full Text Available Warm up routines are commonly used to optimize football performance and prevent injuries. Yet, official pre-match protocols may require players to passively rest for approximately 10 to 15 minutes between the warm up and the beginning of the match. Therefore, the aim of this study was to explore the effect of different re-warm up activities on the physical performance of football players. Twenty-Two Portuguese elite under-19 football players participated in the study conducted during the competitive season. Different re-warm up protocols were performed 6 minutes after the same standardized warm up in 4 consecutive days in a crossover controlled approach: without, eccentric, plyometric and repeated changes of direction. Vertical jump and Sprint performances were tested immediately after warm up and 12 minutes after warm up. Results showed that repeated changes of direction and plyometrics presented beneficial effects to jump and sprint. Different practical implications may be taken from the eccentric protocol since a vertical jump impairment was observed, suggesting a possibly harmful effect. The absence of re-warm up activities may be detrimental to players' physical performance. However, the inclusion of re-warm up prior to match is a complex issue, since the manipulation of volume, intensity and recovery may positively or negatively affect the subsequent performance. In fact, this exploratory study shows that eccentric exercise may be harmful for physical performance when performed prior a football match. However, plyometric and repeated changes of direction exercises seem to be simple, quick and efficient activities to attenuate losses in vertical jump and sprint capacity after warm up. Coaches should aim to develop individual optimal exercise modes in order to optimize physical performance after re warm activities.

  4. The effect of midazolam on neutrophil mitogen-activated protein kinase.

    LENUS (Irish Health Repository)

    Ghori, Kamran

    2010-06-01

    Neutrophil p38 mitogen-activated protein kinase (MAPK) is a key enzyme in the intracellular signalling pathway that is responsible for many neutrophil functions, which are important in neutrophil-endothelial interaction. The imidazole compounds are inhibitors of this enzyme system. The objectives of this in-vitro investigation were to examine the effect of midazolam on neutrophil p38 MAPK activation (phosphorylation) following in-vitro ischaemia-reperfusion injury, and the expression of adhesion molecule CD11b\\/CD18.

  5. The epidemiology of golfrelated injuries in Australian amateur ...

    African Journals Online (AJOL)

    the golf swing (44.8%). Age, warm-up status, conditioning habits, wearing a golf glove/s and injury acquired in other sports / activities were significantly associated with risk of golf injury (p < 0.05). Equipment use such as type of golf club shaft used, type of shoes used and other factors studied were not statistically significant.

  6. Penile Replantation After Five Hours of Warm Ischemia

    Directory of Open Access Journals (Sweden)

    Fernando N. Facio Jr.

    2015-05-01

    Full Text Available Although a rare occurrence, this event may occur as a result of self-mutilation among individuals with psychiatric disturbances or due to work-related accidents, iatrogenic injuries or the actions of individuals motivated by jealously, rage and feelings of betrayal. In western societies, most penile amputations are the result of self-aggression during a psychotic episode, the treatment of victims involves resuscitation, stabilization and immediate psychiatric support. The amputated tissue must be preserved under hypothermic conditions. Micro-surgery is currently the most widely employed method for penile replantation. This paper describes a successful case of penile replantation following 5 hours of warm ischemia.

  7. Versions of the Waste Reduction Model (WARM)

    Science.gov (United States)

    This page provides a brief chronology of changes made to EPA’s Waste Reduction Model (WARM), organized by WARM version number. The page includes brief summaries of changes and updates since the previous version.

  8. Documentation for the Waste Reduction Model (WARM)

    Science.gov (United States)

    This page describes the WARM documentation files and provides links to all documentation files associated with EPA’s Waste Reduction Model (WARM). The page includes a brief summary of the chapters documenting the greenhouse gas emission and energy factors.

  9. Global warming: Clouds cooled the Earth

    Science.gov (United States)

    Mauritsen, Thorsten

    2016-12-01

    The slow instrumental-record warming is consistent with lower-end climate sensitivity. Simulations and observations now show that changing sea surface temperature patterns could have affected cloudiness and thereby dampened the warming.

  10. Eye Injuries

    Science.gov (United States)

    ... that you could lose your vision. Most eye injuries are preventable. If you play sports or work in certain jobs, you may need protection. The most common type of injury happens when something irritates the ...

  11. Ocular Injuries

    African Journals Online (AJOL)

    GB

    2015-04-02

    Apr 2, 2015 ... KEYWORDS: Bangers, eye injuries, holidays, Nigeria ... antibiotic and cycloplegic eye drops, antibiotic ointment at night and .... Adeoti C. O, Bello T. O., Ashaye A. O. Blinding ... Can fireworks-related injuries to children during ...

  12. ACL Injuries

    Science.gov (United States)

    ... while doing things like skiing, playing soccer or football, and jumping on a trampoline. When you injure ... severity of the injury, age, physical condition, medical history, and other injuries or illnesses. People who are ...

  13. Knee Injuries

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Knee Injuries KidsHealth / For Teens / Knee Injuries What's in ... can do to protect them. What's in a Knee? The knee is a joint , actually the largest ...

  14. Musculoskeletal injuries in break-dancers.

    Science.gov (United States)

    Cho, Chul Hyun; Song, Kwang Soon; Min, Byung Woo; Lee, Sung Moon; Chang, Hyuk Won; Eum, Dae Seup

    2009-11-01

    Since no epidemiologic studies have been reported about musculoskeletal injuries in break-dancers, there are no data on the rates and patterns of musculoskeletal injuries in this population that clinicians can use to find ways to decrease injury rate. We believe that the incidence of injuries in break-dancers is higher than assumed and that injury rates and patterns differ between professional and amateur dancers. Descriptive epidemiologic study. Of a total of 42 study subjects, 23 were professional dancers and 19 were amateur dancers. Injury frequency, site and type, along with the presence of supervised training, the use of protective devices and warm-up exercises done were recorded. Of the 42 study subjects, excluding two amateur dancers, 40 (95.2%) had had musculoskeletal injuries at more than one site. The mean number of sites per dancer was 4.60. The frequency of injury depended on the site and was as follows: wrist (69.0%), finger (61.9%), knee (61.9%), shoulder (52.4%), lumbar spine (50.0%), elbow (42.9%), cervical spine (38.1%), ankle (38.1%), foot (28.6%) and hip (16.7%). Sprain, strain and tendinitis were the most common injuries, accounting for the most cases. Of the 42 dancers, 13 (31%) had had fractures or dislocations. Eight (19.1%) learned break-dancing under supervised instruction, 17 (40.5%) used protective devices and 28 (66.7%) performed warm-up exercises before dancing. There were significant differences in age, dance career length, amount of dance training, mean number of injury sites and the presence of supervised training between professionals and amateurs (Pnature of the activities that result in both unusual and common injuries in break-dancers and educate them about safety. Careful screening, instruction and supervised training of break-dancers will help to prevent injuries.

  15. Cosmic rays and global warming

    Energy Technology Data Exchange (ETDEWEB)

    Erlykin, A.D. [P.N. Lebedev Physical Institute, Moscow (Russian Federation); Sloan, T. [Lancaster University (United Kingdom); Wolfendale, A.W. [Durham University (United Kingdom)

    2010-07-01

    The possible effects of cosmic rays on clouds could contribute to global warming. The argument is that the observed increased solar activity during the last century caused a decrease in the ionization due to cosmic rays since the lower energy cosmic particles are deflected by the magnetic field created by the increasing solar wind. This would lead to a decrease in cloud cover allowing more heating of the earth by the sun. Meteorological data combined to solar activity observations and simulations show that any effect of solar activity on clouds and the climate is likely to be through irradiance rather than cosmic rays. Since solar irradiance transfers 8 orders of magnitude more energy to the atmosphere than cosmic rays it is more plausible that this can produce a real effect. The total contribution of variable solar activity to global warming is shown to be less than 14% of the total temperature rise. (A.C.)

  16. Global Warming and Financial Umbrellas

    International Nuclear Information System (INIS)

    Dosi, C.; Moretto, M.

    2001-10-01

    A new instrument for hedging weather risks has made its appearance in the financial arena. Trade in 'weather derivatives' has taken off in the US, and interest is growing elsewhere. Whilst such contracts may be simply interpreted as a new tool for solving a historical problem, the question addressed in this paper is if, besides other factors, the appearance of weather derivatives is somehow related to anthropogenic climate change. Our tentative answer is positive. Since 'global warming' does not simply mean an increase in averaged temperatures, but increased climate variability, and increased frequency and magnitude of weather extremes, derivative contracts may potentially become a useful tool for hedging some weather risks, insofar as they may provide coverage at a lower cost than standard insurance schemes. Keywords: Global warming, climate variability, insurance coverage, weather derivatives

  17. Warm Debris Disks from WISE

    Science.gov (United States)

    Padgett, Deborah L.

    2011-01-01

    "The Wide Field Infrared Survey Explorer (WISE) has just completed a sensitive all-sky survey in photometric bands at 3.4, 4.6, 12, and 22 microns. We report on a preliminary investigation of main sequence Hipparcos and Tycho catalog stars with 22 micron emission in excess of photospheric levels. This warm excess emission traces material in the circumstellar region likely to host terrestrial planets and is preferentially found in young systems with ages warm debris disk candidates are detected among FGK stars and a similar number of A stars within 120 pc. We are in the process of obtaining spectra to determine spectral types and activity level of these stars and are using HST, Herschel and Keck to characterize the dust, multiplicity, and substellar companions of these systems. In this contribution, we will discuss source selection methods and individual examples from among the WISE debris disk candidates. "

  18. Global Warming Blame the Sun

    CERN Document Server

    Calder, N

    1997-01-01

    Concern about climate change reaches a political peak at a UN conference in Kyoto, 1-10 December, but behind the scenes the science is in turmoil. A challenge to the hypothesis that greenhouse gases are responsible for global warming comes from the discovery that cosmic rays from the Galaxy are involved in making clouds (Svensmark and Friis-Christensen, 1997). During the 20th Century the wind from the Sun has grown stronger and the count of cosmic rays has diminished. With fewer clouds, the EarthÕs surface has warmed up. This surprising mechanism explains the link between the Sun and climate change that astronomers and geophysicists have suspected for 200 years.

  19. Plant movements and climate warming

    DEFF Research Database (Denmark)

    De Frenne, Pieter; Coomes, David A.; De Schrijver, An

    2014-01-01

    environments can establish in nonlocal sites. •We assess the intraspecific variation in growth responses to nonlocal soils by planting a widespread grass of deciduous forests (Milium effusum) into an experimental common garden using combinations of seeds and soil sampled in 22 sites across its distributional...... range, and reflecting movement scenarios of up to 1600 km. Furthermore, to determine temperature and forest-structural effects, the plants and soils were experimentally warmed and shaded. •We found significantly positive effects of the difference between the temperature of the sites of seed and soil...... collection on growth and seedling emergence rates. Migrant plants might thus encounter increasingly favourable soil conditions while tracking the isotherms towards currently ‘colder’ soils. These effects persisted under experimental warming. Rising temperatures and light availability generally enhanced plant...

  20. Autophagy and Liver Ischemia-Reperfusion Injury

    Directory of Open Access Journals (Sweden)

    Raffaele Cursio

    2015-01-01

    Full Text Available Liver ischemia-reperfusion (I-R injury occurs during liver resection, liver transplantation, and hemorrhagic shock. The main mode of liver cell death after warm and/or cold liver I-R is necrosis, but other modes of cell death, as apoptosis and autophagy, are also involved. Autophagy is an intracellular self-digesting pathway responsible for removal of long-lived proteins, damaged organelles, and malformed proteins during biosynthesis by lysosomes. Autophagy is found in normal and diseased liver. Although depending on the type of ischemia, warm and/or cold, the dynamic process of liver I-R results mainly in adenosine triphosphate depletion and in production of reactive oxygen species (ROS, leads to both, a local ischemic insult and an acute inflammatory-mediated reperfusion injury, and results finally in cell death. This process can induce liver dysfunction and can increase patient morbidity and mortality after liver surgery and hemorrhagic shock. Whether autophagy protects from or promotes liver injury following warm and/or cold I-R remains to be elucidated. The present review aims to summarize the current knowledge in liver I-R injury focusing on both the beneficial and the detrimental effects of liver autophagy following warm and/or cold liver I-R.

  1. Global warming and climate change

    International Nuclear Information System (INIS)

    1992-10-01

    A panel discussion was held to discuss climate change. Six panelists made presentations that summarized ozone depletion and climate change, discussed global responses, argued against the conventional scientific and policy dogmas concerning climate change, examined the effects of ultraviolet radiation on phytoplankton, examined the effects of carbon taxes on Canadian industry and its emissions, and examined the political and strategic aspects of global warming. A question session followed the presentations. Separate abstracts have been prepared for the six presentations

  2. Global warming and economic growth

    International Nuclear Information System (INIS)

    Gonand, Frederic

    2015-01-01

    The macro-economic impacts of climate change and of policies to reduce carbon content should be moderate on a global basis for the planet - a few hundredths of a % of world GDP on an annual basis, but significant for some regions (Asia-Pacific notably). The probability of extreme climatic events justifies with effect from today the implementation of measures that will carry a cost in order to limit global warming. (author)

  3. Nitrous oxide and global warming

    International Nuclear Information System (INIS)

    Kroeze, C.

    1994-01-01

    The climatic impact of nitrous oxide (N 2 O) emissions is calculated annually for the period 1900-2100, using a globally averaged computer model. Emissions of N 2 O have been increasing up top an estimated 12.7 Tg N/year in 1990 by human activities and global warming. If the current trends continue, emissions are estimated to be 25.7 Tg N/year by 2100, with fossil-fuel use and human food production as major contributors. The resulting equilibrium temperature increase (0.37 degree C) exceeds the forcing derived from climate goals that may be considered environmentally desirable. Limiting equilibrium warming to 0.1 degree C per decade would require anthropogenic-induced and warming-induced N 2 O emissions to be reduced by 80% relative to current trends and to be stabilized from 2050, so that 10.7 Tg N/year is emitted by 2100. To stabilize the current concentration or climate forcing of N 2 , substantially larger cuts are needed. However, even in an optimistic scenario, emissions keep increasing up to 14.4. Tg N/year by 2100. A major reason is the close connection between N 2 O emissions and human food production. Synthetic fertilizer use, land-use change, and production of manure increase almost inevitably as the human population grows. Thus if global warming is to be limited to 0.1 degree C per decade it may be necessary to set emission reductions for other greenhouse gases relatively high to compensate for growth in climatic forcing by N 2 O

  4. Hamstring Injury

    Science.gov (United States)

    Hamstring injury Overview A hamstring injury occurs when you strain or pull one of your hamstring muscles — the group of three muscles that run along ... You may be more likely to get a hamstring injury if you play soccer, basketball, football, tennis ...

  5. Orienteering injuries

    OpenAIRE

    Folan, Jean M.

    1982-01-01

    At the Irish National Orienteering Championships in 1981 a survey of the injuries occurring over the two days of competition was carried out. Of 285 individual competitors there was a percentage injury rate of 5.26%. The article discusses the injuries and aspects of safety in orienteering.

  6. Movement of global warming issues

    International Nuclear Information System (INIS)

    Sugiyama, Taishi

    2015-01-01

    This paper summarizes the report of IPCC (Intergovernmental Panel on Climate Change), and the movement of the global warming issues as seen from the United Nations Framework Convention on Climate Change (Conference of the Parties: COP) and the policy discussions in Japan. From the Fifth Assessment Report published by IPCC, it shows the following items: (1) increasing trends of greenhouse effect gas emissions during 1970 and 2010, (2) trends in world's greenhouse effect gas emissions according to income segment, and (3) factor analysis of changes in greenhouse effect gas emissions. Next, it takes up the greenhouse gas emission scenario of IPCC, shows the scenario due to temperature rise pattern, and introduces the assumption of emission reduction due to BECCS. Regarding the 2 deg. scenario that has become a hot topic in international negotiations, it describes the reason for difficulties in its implementation. In addition, as the international trends of global warming, it describes the agreement of numerical targets for emissions at COP3 (Kyoto Conference) and the subsequent movements. Finally, it introduces Japan's measures against global warming, as well as the future movement. (A.O.)

  7. Global warming: Economic policy responses

    International Nuclear Information System (INIS)

    Dornbusch, R.; Poterba, J.M.

    1991-01-01

    This volume contains the proceedings of a conference that brought together economic experts from Europe, the US, Latin America, and Japan to evaluate key issues in the policy debate in global warming. The following issues are at the center of debates on alternative policies to address global warming: scientific evidence on the magnitude of global warming and the extent to which it is due to human activities; availability of economic tools to control the anthropogenic emissions of greenhouse gases, and how vigorously should they be applied; and political economy considerations which influence the design of an international program for controlling greenhouse gases. Many perspectives are offered on the approaches to remedying environmental problems that are currently being pursued in Europe and the Pacific Rim. Deforestation in the Amazon is discussed, as well as ways to slow it. Public finance assessments are presented of both the domestic and international policy issues raised by plans to levy a tax on the carbon emissions from various fossil fuels. Nine chapters have been processed separately for inclusion in the appropriate data bases

  8. World warms to nuclear power

    International Nuclear Information System (INIS)

    Mortimer, N.

    1989-01-01

    The greenhouse effect and global warming is a major environmental issue. The nuclear industry has taken this opportunity to promote itself as providing clean energy without implication in either the greenhouse effect or acid rain. However, it is acknowledged that nuclear power does have its own environment concerns. Two questions are posed -does nuclear power contribute to carbon dioxide emissions and can nuclear power provide a realistic long-term solution to global warming? Although nuclear power stations do not emit carbon dioxide, emissions occur during the manufacture of reactor components, the operation of the nuclear fuel cycle and especially, during the mining and processing of the uranium ore. It is estimated that the supply of high grade ores will last only 23 years, beyond that the carbon dioxide emitted during the processing is estimated to be as great as the carbon dioxide emitted from an coal-fired reactor. Fast breeder reactors are dismissed as unable to provide an answer, so it is concluded that nuclear technology has only a very limited role to play in countering global warming.(UK)

  9. Greenhouse gases and global warming

    International Nuclear Information System (INIS)

    1995-01-01

    From previous articles we have learned about the complexities of our environment, its atmosphere and its climate system. we have also learned that climate change and, therefore global warm and cool periods are naturally occurring phenomena. Moreover, all scientific evidence suggests that global warming, are likely to occur again naturally in the future. However, we have not yet considered the role of the rates of climate change in affecting the biosphere. It appears that how quickly the climate changes may be more important than the change itself. In light of this concern, let us now consider the possibility that, is due to human activity. We may over the next century experience global warming at rates and magnitudes unparalleled in recent geologic history. The following questions are answered; What can we learn from past climates? What do we know about global climates over the past 100 years? What causes temperature change? What are the greenhouse gases? How much have concentration of greenhouse gases increased in recent years? Why are increases in concentrations of greenhouse of concern? What is the e nhanced greenhouse effect ? How can human activity impact the global climate? What are some reasons for increased concentrations of greenhouse gases? What are fossil fuel and how do they transform into greenhouse gases? Who are the biggest emitters of greenhouse gases? Why are canada per capita emissions of greenhouse gases relatively high? (Author)

  10. Pains and Injuries Caused by Practicing Martial Arts

    OpenAIRE

    Diviš, Ondřej

    2008-01-01

    Title: Pains and Injuries Caused by Practicing Martial Arts Objective: To ascertain, by the means of survey, the most common kinetic system pains and sports injuries as a result of practicing martial arts. Additionally, to collect the data about warm-up, compensation exercises and regeneration and determine the effectofthese on the frequency ofkinetic system pains and sport injuries. Methods: 81 respondents from 5 different martial arts took part in the survey. Each questionnaire illustrates ...

  11. Site and Type Assessments of Sports Injuries in Archers

    Directory of Open Access Journals (Sweden)

    Gizem Kocaman

    2018-03-01

    Conclusion: Most archers are injured in the shoulder, neck and back areas. These injuries are mostly seen as muscle pain. The vast majority of injuries occur in training. In archers, shoulder, neck, and back areas should be more strengthened to reduce injuries. Extra warm-up programmes special to muscles in these sections should be especially applied in trainings and competitions. Shooting techniques are to be correctly applied.

  12. Warm Dense Matter: An Overview

    International Nuclear Information System (INIS)

    Kalantar, D H; Lee, R W; Molitoris, J D

    2004-01-01

    This document provides a summary of the ''LLNL Workshop on Extreme States of Materials: Warm Dense Matter to NIF'' which was held on 20, 21, and 22 February 2002 at the Wente Conference Center in Livermore, CA. The warm dense matter regime, the transitional phase space region between cold material and hot plasma, is presently poorly understood. The drive to understand the nature of matter in this regime is sparking scientific activity worldwide. In addition to pure scientific interest, finite temperature dense matter occurs in the regimes of interest to the SSMP (Stockpile Stewardship Materials Program). So that obtaining a better understanding of WDM is important to performing effective experiments at, e.g., NIF, a primary mission of LLNL. At this workshop we examined current experimental and theoretical work performed at, and in conjunction with, LLNL to focus future activities and define our role in this rapidly emerging research area. On the experimental front LLNL plays a leading role in three of the five relevant areas and has the opportunity to become a major player in the other two. Discussion at the workshop indicated that the path forward for the experimental efforts at LLNL were two fold: First, we are doing reasonable baseline work at SPLs, HE, and High Energy Lasers with more effort encouraged. Second, we need to plan effectively for the next evolution in large scale facilities, both laser (NIF) and Light/Beam sources (LCLS/TESLA and GSI) Theoretically, LLNL has major research advantages in areas as diverse as the thermochemical approach to warm dense matter equations of state to first principles molecular dynamics simulations. However, it was clear that there is much work to be done theoretically to understand warm dense matter. Further, there is a need for a close collaboration between the generation of verifiable experimental data that can provide benchmarks of both the experimental techniques and the theoretical capabilities. The conclusion of this

  13. Impact and prevention on global warming

    International Nuclear Information System (INIS)

    Park, Heon Ryeol

    2003-11-01

    This book deals with impact and prevention on global warming with eight chapters, which introduce the change after the earth was born and natural environment, how is global atmospheric environment under the control of radiant energy? What does global warming look with the earth history like? What's the status of global warming so far? How does climate change happen? What is the impact by global warming and climate change and for preservation of global environment of 21 century with consumption of energy, measure and prospect on global warming. It has reference, index and three appendixes.

  14. Methods of patient warming during abdominal surgery.

    Directory of Open Access Journals (Sweden)

    Li Shao

    Full Text Available BACKGROUND: Keeping abdominal surgery patients warm is common and warming methods are needed in power outages during natural disasters. We aimed to evaluate the efficacy of low-cost, low-power warming methods for maintaining normothermia in abdominal surgery patients. METHODS: Patients (n = 160 scheduled for elective abdominal surgery were included in this prospective clinical study. Five warming methods were applied: heated blood transfusion/fluid infusion vs. unheated; wrapping patients vs. not wrapping; applying moist dressings, heated or not; surgical field rinse heated or not; and applying heating blankets or not. Patients' nasopharyngeal and rectal temperatures were recorded to evaluate warming efficacy. Significant differences were found in mean temperatures of warmed patients compared to those not warmed. RESULTS: When we compared temperatures of abdominal surgery patient groups receiving three specific warming methods with temperatures of control groups not receiving these methods, significant differences were revealed in temperatures maintained during the surgeries between the warmed groups and controls. DISCUSSION: The value of maintaining normothermia in patients undergoing abdominal surgery under general anesthesia is accepted. Three effective economical and practically applicable warming methods are combined body wrapping and heating blanket; combined body wrapping, heated moist dressings, and heating blanket; combined body wrapping, heated moist dressings, and warmed surgical rinse fluid, with or without heating blanket. These methods are practically applicable when low-cost method is indeed needed.

  15. Global warming and obesity: a systematic review.

    Science.gov (United States)

    An, R; Ji, M; Zhang, S

    2018-02-01

    Global warming and the obesity epidemic are two unprecedented challenges mankind faces today. A literature search was conducted in the PubMed, Web of Science, EBSCO and Scopus for articles published until July 2017 that reported findings on the relationship between global warming and the obesity epidemic. Fifty studies were identified. Topic-wise, articles were classified into four relationships - global warming and the obesity epidemic are correlated because of common drivers (n = 21); global warming influences the obesity epidemic (n = 13); the obesity epidemic influences global warming (n = 13); and global warming and the obesity epidemic influence each other (n = 3). We constructed a conceptual model linking global warming and the obesity epidemic - the fossil fuel economy, population growth and industrialization impact land use and urbanization, motorized transportation and agricultural productivity and consequently influences global warming by excess greenhouse gas emission and the obesity epidemic by nutrition transition and physical inactivity; global warming also directly impacts obesity by food supply/price shock and adaptive thermogenesis, and the obesity epidemic impacts global warming by the elevated energy consumption. Policies that endorse deployment of clean and sustainable energy sources, and urban designs that promote active lifestyles, are likely to alleviate the societal burden of global warming and obesity. © 2017 World Obesity Federation.

  16. Global warming-setting the stages

    International Nuclear Information System (INIS)

    1994-01-01

    Most of us have heard or read about global warming. However, the messages we receive are often in conflict, raising more questions than answer. Is global warming a good or a bad thing? has it already started or is it part of our future? Are we, or are we not doing anything about it? Should we be concerned? This primer on Global Warming is designed to clear up some of this confusion by providing basic scientific information on global warming issue. It is clear that there is still much to learn about global warming. However, it is also clear that there is a lot that we already know - and that dose provide cause for concern. We must understand the global warming issue if we are to make wise decisions and take responsible actions in response to the challenges and opportunities posed by global warming. Chapter 1 of 'the primer on global Warming' set the stage with a brief overview of science of global warming within the context of climate change. In addition, it introduces the specific issues that surround the global warming problem. As far as the science of global warming is concerned the following questions are discussed. What is global climate? Is climate change natural? What causes climate to vary on a global scale? How does the composition of the atmosphere relate to climate change. but there are also certain issues discussed here which surround the global warming such as: If climate varies naturally, why is there a concern about 'global warming'? What are the potential consequences of 'global warning'. What human activities contribute to 'global warming'. (Author)

  17. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Cord Injury What is a Spinal Cord Injury Levels of Injury and What They Mean Animated Spinal ... Cord Injury What is a Spinal Cord Injury Levels of Injury and What They Mean Animated Spinal ...

  18. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Injury Chart Spinal Cord Injury Facts and Figures Care and Treatment After SCI Spinal Cord Injury Rehabilitation ... Injury Chart Spinal Cord Injury Facts and Figures Care and Treatment After SCI Spinal Cord Injury Rehabilitation ...

  19. Global Warming and Its Health Impact.

    Science.gov (United States)

    Rossati, Antonella

    2017-01-01

    Since the mid-19th century, human activities have increased greenhouse gases such as carbon dioxide, methane, and nitrous oxide in the Earth's atmosphere that resulted in increased average temperature. The effects of rising temperature include soil degradation, loss of productivity of agricultural land, desertification, loss of biodiversity, degradation of ecosystems, reduced fresh-water resources, acidification of the oceans, and the disruption and depletion of stratospheric ozone. All these have an impact on human health, causing non-communicable diseases such as injuries during natural disasters, malnutrition during famine, and increased mortality during heat waves due to complications in chronically ill patients. Direct exposure to natural disasters has also an impact on mental health and, although too complex to be quantified, a link has even been established between climate and civil violence. Over time, climate change can reduce agricultural resources through reduced availability of water, alterations and shrinking arable land, increased pollution, accumulation of toxic substances in the food chain, and creation of habitats suitable to the transmission of human and animal pathogens. People living in low-income countries are particularly vulnerable. Climate change scenarios include a change in distribution of infectious diseases with warming and changes in outbreaks associated with weather extreme events. After floods, increased cases of leptospirosis, campylobacter infections and cryptosporidiosis are reported. Global warming affects water heating, rising the transmission of water-borne pathogens. Pathogens transmitted by vectors are particularly sensitive to climate change because they spend a good part of their life cycle in a cold-blooded host invertebrate whose temperature is similar to the environment. A warmer climate presents more favorable conditions for the survival and the completion of the life cycle of the vector, going as far as to speed it up

  20. Global Warming and Its Health Impact

    Directory of Open Access Journals (Sweden)

    Antonella Rossati

    2017-01-01

    Full Text Available Since the mid-19th century, human activities have increased greenhouse gases such as carbon dioxide, methane, and nitrous oxide in the Earth's atmosphere that resulted in increased average temperature. The effects of rising temperature include soil degradation, loss of productivity of agricultural land, desertification, loss of biodiversity, degradation of ecosystems, reduced fresh-water resources, acidification of the oceans, and the disruption and depletion of stratospheric ozone. All these have an impact on human health, causing non-communicable diseases such as injuries during natural disasters, malnutrition during famine, and increased mortality during heat waves due to complications in chronically ill patients. Direct exposure to natural disasters has also an impact on mental health and, although too complex to be quantified, a link has even been established between climate and civil violence. Over time, climate change can reduce agricultural resources through reduced availability of water, alterations and shrinking arable land, increased pollution, accumulation of toxic substances in the food chain, and creation of habitats suitable to the transmission of human and animal pathogens. People living in low-income countries are particularly vulnerable. Climate change scenarios include a change in distribution of infectious diseases with warming and changes in outbreaks associated with weather extreme events. After floods, increased cases of leptospirosis, campylobacter infections and cryptosporidiosis are reported. Global warming affects water heating, rising the transmission of water-borne pathogens. Pathogens transmitted by vectors are particularly sensitive to climate change because they spend a good part of their life cycle in a cold-blooded host invertebrate whose temperature is similar to the environment. A warmer climate presents more favorable conditions for the survival and the completion of the life cycle of the vector, going as far

  1. US demilitarization and global warming

    International Nuclear Information System (INIS)

    Heyes, A.G.; Liston-Heyes, C.; Royal Holloway and Bedford New College, London

    1993-01-01

    In the paper input-output methods are used to generate ballpark empirical estimates of the implications for global warming of the projected demilitarization of the US federal budget. The impact is found to be qualitatively ambiguous, and highly sensitive to the manner in which the funds saved are distributed. The effect is adverse where the budgetary savings are used to fund economy-wide cuts in personal taxation and/or deficit reduction. In other cases the effect may be neutral or beneficial. (author)

  2. Synergistic effects of remote perconditioning with terminal blood cardioplegia in an in vivo piglet model.

    Science.gov (United States)

    Abe, Takayuki; Morita, Kiyozo; Shinohara, Gen; Hashimoto, Kazuhiro; Nishikawa, Masako

    2017-09-01

    This study tested the hypothesis that remote perconditioning offers effective and synergistic cardioprotection to terminal warm blood cardioplegia for prompt ventricular recovery after prolonged cardioplegic arrest in an in vivo piglet model. Twenty-four piglets were subjected to 120 min of single-dose cardioplegic arrest and were divided into 4 groups according to the mode of reperfusion: control (simple aortic unclamp), remote perconditioning, terminal warm blood cardioplegia or remote perconditioning + terminal warm blood cardioplegia; remote perconditioning (4 cycles of 5-min ischaemia-reperfusion of the lower limb) was applied prior to aortic unclamping. Left ventricular systolic and diastolic functions were assessed by pressure-volume loop analysis at baseline and after 60 min of reperfusion. Biochemical injury was evaluated by plasma troponin T level. The control group showed decreased end-systolic elastance, preload recruitable stroke work and inverse of end-diastolic pressure-volume relationship of 51.3 ± 14.0%, 46.1 ± 22.5% and 34.8 ± 14.9%, respectively. Percentage recovery of end-systolic elastance and preload recruitable stroke work were significantly better with terminal warm blood cardioplegia (with or without remote perconditioning) (end-systolic elastance: 95% confidence interval, 38.6-84.1; preload recruitable stroke work: 95% confidence interval, 0.4-54.3). Percentage recovery of inverse of end-diastolic pressure-volume relationship was significantly better in the remote perconditioning groups (with or without terminal warm blood cardioplegia) (95% confidence interval, 1.6-41.6). No synergistic effects of remote perconditioning and terminal warm blood cardioplegia on troponin T release were noted. Remote perconditioning offers promising synergistic cardioprotection to terminal warm blood cardioplegia, implicating potential clinical benefit by contributing to prompt left ventricular functional recovery during paediatric open

  3. Recognition and Prevention of Rugby Injuries.

    Science.gov (United States)

    Tomasin, J D; Martin, D F; Curl, W W

    1989-06-01

    In brief: Rugby is a popular, strenuous contact sport that demands almost continuous action by the players. Players, coaches, and physicians must be aware of the potential for and types of injuries that occur during matches and of ways to avoid, or at least reduce, this number and severity. Minor and moderate injuries are more frequent than severe injuries, but all must be regarded seriously. Concussions, although relatively rare, can have serious consequences, and cervical spine injuries can be catastrophic. Player fitness and conditioning and a pregame warm-up are all essential for preventing injuries. Equally important are coaching, adherence to the rules of the game, and avoidance of dangerous play. If these measures are practiced consistently, rugby will be safer.

  4. Metabolic changes in the pig liver during warm ischemia and reperfusion measured by microdialysis

    DEFF Research Database (Denmark)

    Kannerup, Anne-Sofie; Funch-Jensen, Peter; Grønbaek, Henning

    2008-01-01

    AIM: Portal triad clamping can cause ischemia-reperfusion injury. The aim of the study was to monitor metabolic changes by microdialysis before, during, and after warm ischemia in the pigliver. MATERIAL AND METHODS: Eight pigs underwent laparotomy followed by ischemia by Pringle's maneuver. One...... in transaminase levels was observed. CONCLUSIONS: During and after warm ischemia, there were profound metabolic changes in the pigliver observed with an increase in lactate, glucose, glycerol, and the lactate-pyruvate ratio. There were no differences between the four liver lobes, indicating the piglivers...

  5. Paragliding injuries.

    OpenAIRE

    Krüger-Franke, M; Siebert, C H; Pförringer, W

    1991-01-01

    Regulations controlling the sport of paragliding were issued in April 1987 by the German Department of Transportation. The growing popularity of this sport has led to a steady increase in the number of associated injuries. This study presents the incidence, localization and degree of injuries associated with paragliding documented in Germany, Austria and Switzerland. The 283 injuries suffered by 218 paragliders were documented in the period 1987-1989: 181 occurred during landing, 28 during st...

  6. Global warming potential of pavements

    Energy Technology Data Exchange (ETDEWEB)

    Santero, Nicholas J [Department of Civil and Environmental Engineering, 407 McLaughlin Hall, University of California, Berkeley, CA 94720-1712 (United States); Horvath, Arpad, E-mail: njsantero@cal.berkeley.ed, E-mail: horvath@ce.berkeley.ed [Department of Civil and Environmental Engineering, 215B McLaughlin Hall, University of California, Berkeley, CA 94720-1712 (United States)

    2009-09-15

    Pavements comprise an essential and vast infrastructure system supporting our transportation network, yet their impact on the environment is largely unquantified. Previous life-cycle assessments have only included a limited number of the applicable life-cycle components in their analysis. This research expands the current view to include eight different components: materials extraction and production, transportation, onsite equipment, traffic delay, carbonation, lighting, albedo, and rolling resistance. Using global warming potential as the environmental indicator, ranges of potential impact for each component are calculated and compared based on the information uncovered in the existing research. The relative impacts between components are found to be orders of magnitude different in some cases. Context-related factors, such as traffic level and location, are also important elements affecting the impacts of a given component. A strategic method for lowering the global warming potential of a pavement is developed based on the concept that environmental performance is improved most effectively by focusing on components with high impact potentials. This system takes advantage of the fact that small changes in high-impact components will have more effect than large changes in low-impact components.

  7. Global warming potential of pavements

    International Nuclear Information System (INIS)

    Santero, Nicholas J; Horvath, Arpad

    2009-01-01

    Pavements comprise an essential and vast infrastructure system supporting our transportation network, yet their impact on the environment is largely unquantified. Previous life-cycle assessments have only included a limited number of the applicable life-cycle components in their analysis. This research expands the current view to include eight different components: materials extraction and production, transportation, onsite equipment, traffic delay, carbonation, lighting, albedo, and rolling resistance. Using global warming potential as the environmental indicator, ranges of potential impact for each component are calculated and compared based on the information uncovered in the existing research. The relative impacts between components are found to be orders of magnitude different in some cases. Context-related factors, such as traffic level and location, are also important elements affecting the impacts of a given component. A strategic method for lowering the global warming potential of a pavement is developed based on the concept that environmental performance is improved most effectively by focusing on components with high impact potentials. This system takes advantage of the fact that small changes in high-impact components will have more effect than large changes in low-impact components.

  8. Economic approaches to greenhouse warming

    International Nuclear Information System (INIS)

    Nordhaus, W.D.

    1991-01-01

    Global environmental problems raise a host of major policy questions. They are all scientifically complex and controversial, and no scientific consensus is likely to emerge until irreversible decisions have been made. The costs and benefits of these changes transcend national boundaries, and nations, which cannot appropriate the global costs and benefits of such changes, are unlikely to be able or willing to make efficient decisions on how to combat these global externalities. In addition, these concerns sometimes have impacts over hundreds of years and thereby strain political decision making, which often functions effectively only when the crisis is at hand. This chapter considers some of the economic issues involved in deciding how to react to the threat of global warming. The author first reviews the theory and evidence on the greenhouse effect. He then presents evidence on the impacts of greenhouse warming, the costs of stabilizing climate, and the kinds of adaptations that might be available. In the final section, he reviews the policy initiatives that nations might follow in the near term

  9. Paragliding injuries.

    Science.gov (United States)

    Krüger-Franke, M; Siebert, C H; Pförringer, W

    1991-06-01

    Regulations controlling the sport of paragliding were issued in April 1987 by the German Department of Transportation. The growing popularity of this sport has led to a steady increase in the number of associated injuries. This study presents the incidence, localization and degree of injuries associated with paragliding documented in Germany, Austria and Switzerland. The 283 injuries suffered by 218 paragliders were documented in the period 1987-1989: 181 occurred during landing, 28 during starting procedures and nine during flight. The mean patient age was 29.6 years. There were 34.9% spinal injuries, 13.4% upper extremity injuries and 41.3% lower limb injuries. Over half of these injuries were treated surgically and in 54 instances permanent disability remained. In paragliding the lower extremities are at greatest risk of injury during landing. Proper equipment, especially sturdy footwear, exact training in landing techniques as well as improved instruction in procedures during aborted or crash landings is required to reduce the frequency of these injuries.

  10. Daytime warming has stronger negative effects on soil nematodes than night-time warming

    Science.gov (United States)

    Yan, Xiumin; Wang, Kehong; Song, Lihong; Wang, Xuefeng; Wu, Donghui

    2017-03-01

    Warming of the climate system is unequivocal, that is, stronger warming during night-time than during daytime. Here we focus on how soil nematodes respond to the current asymmetric warming. A field infrared heating experiment was performed in the western of the Songnen Plain, Northeast China. Three warming modes, i.e. daytime warming, night-time warming and diurnal warming, were taken to perform the asymmetric warming condition. Our results showed that the daytime and diurnal warming treatment significantly decreased soil nematodes density, and night-time warming treatment marginally affected the density. The response of bacterivorous nematode and fungivorous nematode to experimental warming showed the same trend with the total density. Redundancy analysis revealed an opposite effect of soil moisture and soil temperature, and the most important of soil moisture and temperature in night-time among the measured environment factors, affecting soil nematode community. Our findings suggested that daily minimum temperature and warming induced drying are most important factors affecting soil nematode community under the current global asymmetric warming.

  11. The physics and history of global warming

    International Nuclear Information System (INIS)

    Hu Yongyun

    2012-01-01

    Global warming is not only a hot research area in atmospheric sciences and even all Earth sciences but is also a controversial topic in the international community. The purpose of this paper is not to clarify these controversies, but instead, to address the physical basis on which our understanding of global warming is founded, and to briefly review the nearly 200-year history of global warming sciences. We hope the paper will help readers, who have no background in the atmospheric and climate sciences, understand scientific issues of global warming. (author)

  12. Whiplash injuries.

    Science.gov (United States)

    Malanga, Gerard; Peter, Jason

    2005-10-01

    Whiplash injuries are very common and usually are associated with rear-end collisions. However, a whiplash injury can be caused by any event that results in hyperextension and flexion of the cervical spine. These injuries are of serious concern to all consumers due to escalating cost of diagnosis, treatment, insurance, and litigation. Most acute whiplash injury cases respond well to conservative treatments, which result in resolution of symptoms usually within weeks to a few months after the injury occurred. Chronic whiplash injuries often are harder to diagnose and treat and often result in poor outcomes. Current research shows that various structures in the cervical spine receive nociceptive innervation and potentially may be the cause of chronic pain symptoms. One potential pain generator showing promise is the facet or zygapophyseal joints. Various researchers have proven that these joints are injured during whiplash injuries and that diagnosis and temporary pain relief can be obtained with facet joint injections. The initial evaluation of any patient should follow an organized and stepwise approach, and more serious causes of neck pain must first be ruled out through the history, physical examination, and diagnostic testing. Treatment regimens should be evidence-based, focusing on treatments that have proven to be effective in treating acute and chronic whiplash injuries.

  13. Ocular Injury

    Science.gov (United States)

    ... trauma can happen at home, school, play or sports. Most common injuries are scratches to the cornea or blunt trauma. Approved and tested eye and face protection is essential to prevent injuries. Sports such as hockey, baseball, racquet ball, squash, and ...

  14. Rowing Injuries

    DEFF Research Database (Denmark)

    Thornton, Jane S; Vinther, Anders; Wilson, Fiona

    2017-01-01

    understanding in pre-participation screening, training load, emerging concepts surrounding back and rib injury, and relative energy deficiency in sport. Through a better understanding of the nature of the sport and mechanisms of injury, physicians and other healthcare providers will be better equipped to treat...

  15. Trampoline injuries.

    Science.gov (United States)

    Nysted, M; Drogset, J O

    2006-12-01

    To describe the mechanism, location and types of injury for all patients treated for trampoline-associated injuries at St Olav's University Hospital, Trondheim, Norway, from March 2001to October 2004. Patients were identified from a National Injury Surveillance System. All patients were asked to complete a standard questionnaire at their first visit at the hospital. Most data were recorded prospectively, but data on the mechanism of injury, the number of participants on the trampoline at the time of injury, adult supervision and whether the activity occurred at school or in another organised setting were collected retrospectively. A total of 556 patients, 56% male and 44% female, were included. The mean age of patients was 11 (range 1-62) years. 77% of the injuries occurred on the body of the trampoline, including falls on to the mat, collisions with another jumper, falls on to the frame or the springs, and performing a somersault, whereas 22% of the people fell off the trampoline. In 74% of the cases, more than two people were on the trampoline, with as many as nine trampolinists noted at the time of injury. For children Trampolining can cause serious injuries, especially in the neck and elbow areas of young children. The use of a trampoline is a high-risk activity. However, a ban is not supported. The importance of having safety guidelines for the use of trampolines is emphasised.

  16. The effect of warm-ups with stretching on the isokinetic moments of collegiate men.

    Science.gov (United States)

    Park, Hyoung-Kil; Jung, Min-Kyung; Park, Eunkyung; Lee, Chang-Young; Jee, Yong-Seok; Eun, Denny; Cha, Jun-Youl; Yoo, Jaehyun

    2018-02-01

    Performing warm-ups increases muscle temperature and blood flow, which contributes to improved exercise performance and reduced risk of injuries to muscles and tendons. Stretching increases the range of motion of the joints and is effective for the maintenance and enhancement of exercise performance and flexibility, as well as for injury prevention. However, stretching as a warm-up activity may temporarily decrease muscle strength, muscle power, and exercise performance. This study aimed to clarify the effect of stretching during warm-ups on muscle strength, muscle power, and muscle endurance in a nonathletic population. The subjects of this study consisted of 13 physically active male collegiate students with no medical conditions. A self-assessment questionnaire regarding how well the subjects felt about their physical abilities was administered to measure psychological readiness before and after the warm-up. Subjects performed a non-warm-up, warm-up, or warm-up regimen with stretching prior to the assessment of the isokinetic moments of knee joints. After the measurements, the respective variables were analyzed using nonparametric tests. First, no statistically significant intergroup differences were found in the flexor and extensor peak torques of the knee joints at 60°/sec, which were assessed to measure muscle strength. Second, no statistically significant intergroup differences were found in the flexor and extensor peak torques of the knee joints at 180°/sec, which were assessed to measure muscle power. Third, the total work of the knee joints at 240°/sec, intended to measure muscle endurance, was highest in the aerobic-stretch-warm-ups (ASW) group, but no statistically significant differences were found among the groups. Finally, the psychological readiness for physical activity according to the type of warm-up was significantly higher in ASW. Simple stretching during warm-ups appears to have no effect on variables of exercise physiology in nonathletes

  17. Warm liquid calorimetry for LHC

    CERN Document Server

    Geulig,E; Wallraff,W; Bézaguet, Alain-Arthur; Cavanna, F; Cinnini, P; Cittolin, Sergio; Dreesen, P; Demoulin, M; Dunps, L; Fucci, A; Gallay, G; Givernaud, Alain; Gonidec, A; Jank, Werner; Maurin, Guy; Placci, Alfredo; Porte, J P; Radermacher, E; Samyn, D; Schinzel, D; Schmidt, W F; CERN. Geneva. Detector Research and Development Committee

    1990-01-01

    Results from the beam tests of the U/TMP "warm liquid" calorimeter show that such a technique is very promising for the LHC. Our aim is to extend this programme and design a calorimeter that can satisfy the requirements of high rates, high radiation levels, compensation, uniformity and granularity, as well as fully contain hadronic showers. We propose to construct liquid ionization chambers operated at very high fields, capable of collecting the total charge produced by ionizing particles within times comparable to the bunch crossing time of the future Collider. For this reason we plan to extend the current programme on tetramethylpentane (TMP) to tetramethylsilane (TMSi). An electromagnetic calorimeter consisting of very high field ionization chambers filled with TMSi as sensitive medium with Uranium and/or other high density material as absorber will first be built (to be followed by a full-scale calorimeter module), on which newly designed fast amplifiers and readout electronics will be tested. In addition...

  18. The tragedy of global warming

    International Nuclear Information System (INIS)

    Dominique Auverlot

    2014-01-01

    The author first evokes the consequences of global warming: ocean acidity, ice melt, sea level rise, repeated and always more intense extreme climatic events (a list of the main meteorological and climatic events which occurred in 2013 is given). He outlines that these phenomena happen more quickly than foreseen. He notices that these facts confirm the content of the different IPCC reports. The author outlines the need to reduce greenhouse gas emissions. He discusses the evolutions of these emissions between 1970 and 2010 in the different countries with respect to their level of economic development. It clearly appears that developed countries produce more emissions, and have only stabilized their emission level whereas emerging countries have notably increased their emissions. Developed and emerging countries should therefore act as quickly as possible

  19. Automobility: Global Warming as Symptomatology

    Directory of Open Access Journals (Sweden)

    Gary Backhaus

    2009-04-01

    Full Text Available The argument of this paper is that sustainability requires a new worldview-paradigm. It critically evaluates Gore’s liberal-based environmentalism in order to show how “shallow ecologies” are called into question by deeper ecologies. This analysis leads to the notion that global warming is better understood as a symptom indicative of the worldview that is the source for environmental crises. Heidegger’s ontological hermeneutics and its critique of modern technology show that the modern worldview involves an enframing (a totalizing technological ordering of the natural. Enframing reveals entities as standing reserve (on demand energy suppliers. My thesis maintains that enframing is geographically expressed as automobility. Because of the energy needs used to maintain automobility, reaching the goal of sustainability requires rethinking the spatial organization of life as a function of stored energy technologies.

  20. Warm anisotropic inflationary universe model

    International Nuclear Information System (INIS)

    Sharif, M.; Saleem, Rabia

    2014-01-01

    This paper is devoted to the study of warm inflation using vector fields in the background of a locally rotationally symmetric Bianchi type I model of the universe. We formulate the field equations, and slow-roll and perturbation parameters (scalar and tensor power spectra as well as their spectral indices) in the slow-roll approximation. We evaluate all these parameters in terms of the directional Hubble parameter during the intermediate and logamediate inflationary regimes by taking the dissipation factor as a function of the scalar field as well as a constant. In each case, we calculate the observational parameter of interest, i.e., the tensor-scalar ratio in terms of the inflaton. The graphical behavior of these parameters shows that the anisotropic model is also compatible with WMAP7 and the Planck observational data. (orig.)

  1. Warm anisotropic inflationary universe model

    Energy Technology Data Exchange (ETDEWEB)

    Sharif, M.; Saleem, Rabia [University of the Punjab, Department of Mathematics, Lahore (Pakistan)

    2014-02-15

    This paper is devoted to the study of warm inflation using vector fields in the background of a locally rotationally symmetric Bianchi type I model of the universe. We formulate the field equations, and slow-roll and perturbation parameters (scalar and tensor power spectra as well as their spectral indices) in the slow-roll approximation. We evaluate all these parameters in terms of the directional Hubble parameter during the intermediate and logamediate inflationary regimes by taking the dissipation factor as a function of the scalar field as well as a constant. In each case, we calculate the observational parameter of interest, i.e., the tensor-scalar ratio in terms of the inflaton. The graphical behavior of these parameters shows that the anisotropic model is also compatible with WMAP7 and the Planck observational data. (orig.)

  2. How to stop global warming

    International Nuclear Information System (INIS)

    Goldenberg, J.

    1990-01-01

    This paper reports on how to stop global warming. At the Toronto Conference on Climate Change in 1988, the world's industrialized nations agreed on a goal of cutting greenhouse gas emissions 20 percent by the year 2005. This would not stabilize atmospheric levels of greenhouse gases but would at least slow their accumulation. Although difficult to achieve, the Toronto goal is certainly reachable. Newer, more efficient technologies can lower energy consumption without effecting economic output. CFC- substitutes can provide refrigeration. In fact, an international carbon tax of just $1 per barrel of oil, or $6 per ton of coal, would generate more than enough revenue to pay for the necessary fuel-saving measures. This tax could result from an international agreement similar to the 1987 Montreal Protocol, which obliges its signatories to cut down on production of CFCs

  3. The economics of global warming

    International Nuclear Information System (INIS)

    Pillet, G.; Hediger, W.; Kypreos, S.; Corbaz, C.

    1993-05-01

    The global warming threat is challenging the world community to both international cooperation and national policy action. This report focuses on the necessity to alternate between ''global and national climate policies''. The Swiss perspective is at issue. The economic rationales for comparing national climate policy options are analyzed. This report explicitly focusses on the fundamental role of the normative framework and the related environmental-economic requisites for establishing an efficient national climate policy and computing a ''carbon tax''. Finally, the latest results of the energy and greenhouse gas scenarios for Switzerland, elaborated on within the network of the IEA/ETSAP Project, Annex IV, ''Greenhouse Gases and National Energy Options: Technologies and Costs for Reducing Emissions of Greenhouse Gases'', illustrate Switzerland's difficulties in reducing greenhouse gas emissions at ''reasonable cost'' compared with other countries. This should make Switzerland very sensitive to the implementation of efficient environmental-policy instruments and international cooperation. (author) figs., tabs., refs

  4. The Triaging and Treatment of Cold-Induced Injuries.

    Science.gov (United States)

    Sachs, Christoph; Lehnhardt, Marcus; Daigeler, Adrien; Goertz, Ole

    2015-10-30

    In Central Europe, cold-induced injuries are much less common than burns. In a burn center in western Germany, the mean ratio of these two types of injury over the past 10 years was 1 to 35. Because cold-induced injuries are so rare, physicians often do not know how to deal with them. This article is based on a review of publications (up to December 2014) retrieved by a selective search in PubMed using the terms "freezing," "frostbite injury," "non-freezing cold injury," and "frostbite review," as well as on the authors' clinical experience. Freezing and cold-induced trauma are part of the treatment spectrum in burn centers. The treatment of cold-induced injuries is not standardized and is based largely on case reports and observations of use. distinction is drawn between non-freezing injuries, in which there is a slow temperature drop in tissue without freezing, and freezing injuries in which ice crystals form in tissue. In all cases of cold-induced injury, the patient should be slowly warmed to 22°-27°C to prevent reperfusion injury. Freezing injuries are treated with warming of the body's core temperature and with the bathing of the affected body parts in warm water with added antiseptic agents. Any large or open vesicles that are already apparent should be debrided. To inhibit prostaglandin-mediated thrombosis, ibuprofen is given (12 mg/kg body weight b.i.d.). The treatment of cold-induced injuries is based on their type, severity, and timing. The recommendations above are grade C recommendations. The current approach to reperfusion has yielded promising initial results and should be further investigated in prospective studies.

  5. Keeping cool on global warming

    International Nuclear Information System (INIS)

    Seitz, F.; Hawkins, W.; Nierenberg, W.; Salmon, J.; Jastrow, R.; Moore, J.H.

    1992-01-01

    A number of scientific groups have concluded that the greenhouse effect caused by the man-made emissions of carbon dioxide and other bases has produced much or all of the rise in global temperatures. They predict that there will be an increase in greenhouse gases equivalent to a doubling of carbon dioxide by the middle of the 21st century, and that this will cause the temperature of the earth to rise by as much as 5C. According to these scientists, a temperature rise of this magnitude would cause major disruptions in the earth's ecosystem, including severe summer drought in the midwestern US and other agricultural regions. The worst-case scenarios predict a major rise in sea level as a result of the greenhouse warming, inundating areas of New York, Miami and other coastal cities as well as low-lying river deltas and islands. The lives of hundreds of millions of people would be disrupted. The available data on climate change, however, do not support these predictions, nor do they support the idea that human activity has caused, or will cause, a dangerous increase in global temperatures. As the authors make this statement, they are aware that it contradicts widespread popular opinion, as well as the technical judgments of some of their colleagues. But it would be imprudent to ignore the facts on global warming that have accumulated over the last two years. These facts indicate that theoretical estimates of the greenhouse problem have greatly exaggerated its seriousness. Enormous economic stakes ride on forthcoming government decisions regarding carbon taxes and other restrictions on CO 2 emissions. Due attention must therefore be given to the scientific evidence, no matter how contrary to popular opinion its implications appear to be. This article discusses the scientific evidence

  6. Design and performance of combined infrared canopy and belowground warming in the B4WarmED (Boreal Forest Warming at an Ecotone in Danger) experiment.

    Science.gov (United States)

    Rich, Roy L; Stefanski, Artur; Montgomery, Rebecca A; Hobbie, Sarah E; Kimball, Bruce A; Reich, Peter B

    2015-06-01

    Conducting manipulative climate change experiments in complex vegetation is challenging, given considerable temporal and spatial heterogeneity. One specific challenge involves warming of both plants and soils to depth. We describe the design and performance of an open-air warming experiment called Boreal Forest Warming at an Ecotone in Danger (B4WarmED) that addresses the potential for projected climate warming to alter tree function, species composition, and ecosystem processes at the boreal-temperate ecotone. The experiment includes two forested sites in northern Minnesota, USA, with plots in both open (recently clear-cut) and closed canopy habitats, where seedlings of 11 tree species were planted into native ground vegetation. Treatments include three target levels of plant canopy and soil warming (ambient, +1.7°C, +3.4°C). Warming was achieved by independent feedback control of voltage input to aboveground infrared heaters and belowground buried resistance heating cables in each of 72-7.0 m(2) plots. The treatments emulated patterns of observed diurnal, seasonal, and annual temperatures but with superimposed warming. For the 2009 to 2011 field seasons, we achieved temperature elevations near our targets with growing season overall mean differences (∆Tbelow ) of +1.84°C and +3.66°C at 10 cm soil depth and (∆T(above) ) of +1.82°C and +3.45°C for the plant canopies. We also achieved measured soil warming to at least 1 m depth. Aboveground treatment stability and control were better during nighttime than daytime and in closed vs. open canopy sites in part due to calmer conditions. Heating efficacy in open canopy areas was reduced with increasing canopy complexity and size. Results of this study suggest the warming approach is scalable: it should work well in small-statured vegetation such as grasslands, desert, agricultural crops, and tree saplings (<5 m tall). © 2015 John Wiley & Sons Ltd.

  7. Acute Warm-up Effects in Submaximal Athletes: An EMG Study of Skilled Violinists.

    Science.gov (United States)

    McCrary, J Matt; Halaki, Mark; Sorkin, Evgeny; Ackermann, Bronwen J

    2016-02-01

    Warm-up is commonly recommended for injury prevention and performance enhancement across all activities, yet this recommendation is not supported by evidence for repetitive submaximal activities such as instrumental music performance. The objective of this study is to quantify the effects of cardiovascular, core muscle, and musical warm-ups on muscle activity levels, musical performance, and subjective experience in skilled violinists. Fifty-five undergraduate, postgraduate, or professional violinists performed five randomly ordered 45-s musical excerpts of varying physical demands both before and after a randomly assigned 15-min, moderate-intensity cardiovascular, core muscle, musical (technical violin exercises), or inactive control warm-up protocol. Surface EMG data were obtained for 16 muscles of the trunk, shoulders, and right arm during each musical performance. Sound recording and perceived exertion (RPE) data were also obtained. Sound recordings were randomly ordered and rated for performance quality by blinded adjudicators. Questionnaire data regarding participant pain sites and fitness levels were used to stratify participants according to pain and fitness levels. Data were analyzed using two- and three-factor ANCOVA (surface EMG and sound recording) and Wilcoxon matched pairs tests (RPE). None of the three warm-up protocols had significant effects on muscle activity levels (P ≥ 0.10). Performance quality did not significantly increase (P ≥ 0.21). RPE significantly decreased (P warm-up for each of the three experimental warm-ups; control condition RPE did not significantly decrease (P > 0.23). Acute physiological and musical benefits from cardiovascular, core muscle, and musical warm-ups in skilled violinists are limited to decreases in RPE. This investigation provides data from the performing arts in support of sports medical evidence suggesting that warm-up only effectively enhances maximal strength and power performance.

  8. Injury - kidney and ureter

    Science.gov (United States)

    ... kidney; Ureteral injury; Pre-renal failure - injury, Post-renal failure - injury; Kidney obstruction - injury Images Kidney anatomy Kidney - blood and urine flow References Molitoris BA. Acute kidney injury. In: Goldman ...

  9. Spinal Cord Injury 101

    Medline Plus

    Full Text Available menu Understanding Spinal Cord Injury What is a Spinal Cord Injury Levels of Injury and What They Mean Animated Spinal Cord Injury Chart Spinal Cord Injury Facts and Figures Care and Treatment After SCI Spinal ...

  10. Repetitive Stress Injuries

    Science.gov (United States)

    ... Safe Videos for Educators Search English Español Repetitive Stress Injuries KidsHealth / For Teens / Repetitive Stress Injuries What's ... t had any problems since. What Are Repetitive Stress Injuries? Repetitive stress injuries (RSIs) are injuries that ...

  11. Using isotopes for global warming observation

    International Nuclear Information System (INIS)

    Namata, K.

    2002-01-01

    This paper, based on a literature review, discusses the main aspects of using isotopic techniques to obtain information about global warming. The rapid increase concentration of carbon dioxide (CO 2 ) and methane (CH 4 ) in the atmosphere will result in global warming by the greenhouse effect, and the isotopic techniques constitute an efficient tool to explain this complex environmental phenomenon. (author)

  12. Mitigation of global warming through renewable biomass

    International Nuclear Information System (INIS)

    Dhillon, R.S.; Wuehlisch, George von

    2013-01-01

    Rising level of atmospheric CO 2 and consequent global warming is evident. Global surface temperature have already increased by 0.8 °C over the 20th century and is projected to increase by 1.4–5.8 °C during the twenty-first century. The global warming will continue till atmospheric concentrations of the major greenhouse gases are stabilized. Among them, CO 2 is mainly responsible and is expected to account for about 60% of the warming over the next century. This study reviews advances on causes and consequences of global climate change and its impact on nature and society. Renewable biomass has tremendous potential to mitigate the global warming. Renewable biomass is expected to play a multifunctional role including food production, source of energy and fodder, biodiversity conservation, yield of goods and services to the society as well as mitigation of the impact of climate change. The review highlights the different management and research strategies in forestry, agriculture, agroforestry and grasslands to mitigate the global warming. -- Highlights: ► Rising level of atmospheric CO 2 and consequent global warming is evident. ► CO 2 is mainly responsible for global warming. ► Global temperature is predicted to increase by 1.4–5.8 °C during 21st century. ► Renewable biomass has great potential to mitigate the global warming

  13. Strategies for mitigation of global warming

    DEFF Research Database (Denmark)

    Meyer, Niels I

    2009-01-01

    The paper analyses the international negotions on climate change leading up to COP15 in Copenhagen. Supplementary policies for mitigation of global warming are proposed.......The paper analyses the international negotions on climate change leading up to COP15 in Copenhagen. Supplementary policies for mitigation of global warming are proposed....

  14. Global Warming: Understanding and Teaching the Forecast.

    Science.gov (United States)

    Andrews, Bill

    1994-01-01

    A resource for the teaching of the history and causes of climate change. Discusses evidence of climate change from the Viking era, early ice ages, the most recent ice age, natural causes of climate change, human-made causes of climate change, projections of global warming, and unequal warming. (LZ)

  15. Global Warming: Lessons from Ozone Depletion

    Science.gov (United States)

    Hobson, Art

    2010-01-01

    My teaching and textbook have always covered many physics-related social issues, including stratospheric ozone depletion and global warming. The ozone saga is an inspiring good-news story that's instructive for solving the similar but bigger problem of global warming. Thus, as soon as students in my physics literacy course at the University of…

  16. National Security Implications of Global Warming Policy

    Science.gov (United States)

    2010-03-01

    Although numerous historical examples demonstrate how actual climate change has contributed to the rise and fall of powers, global warming , in and of...become convinced that global warming is universally bad and humans are the primary cause, political leaders may develop ill-advised policies restricting

  17. Exploring the Sociopolitical Dimensions of Global Warming

    Science.gov (United States)

    Sadler, Troy D.; Klosterman, Michelle L.

    2009-01-01

    The authors present an activity to help high school students conceptualize the sociopolitical complexity of global warming through an exploration of varied perspectives on the issue. They argue that socioscientific issues such as global warming present important contexts for learning science and that the social and political dimensions of these…

  18. Global Warming: How Much and Why?

    Science.gov (United States)

    Lanouette, William

    1990-01-01

    Summarizes the history of the study of global warming and includes a discussion of the role of gases, like carbon dioxide, methane, and chlorofluorocarbon (CFC). Discusses modern research on the global warming, including computer modelling and the super-greenhouse effect. (YP)

  19. Catching a Cold When It's Warm

    Science.gov (United States)

    ... Print this issue Catching a Cold When It’s Warm What’s the Deal with Summertime Sniffles? En español ... more unfair than catching a cold when it’s warm? How can cold symptoms arise when it’s not ...

  20. Turkish Students' Ideas about Global Warming

    Science.gov (United States)

    Kilinc, Ahmet; Stanisstreet, Martin; Boyes, Edward

    2008-01-01

    A questionnaire was used to explore the prevalence of ideas about global warming in Year 10 (age 15-16 years) school students in Turkey. The frequencies of individual scientific ideas and misconceptions about the causes, consequences and "cures" of global warming were identified. In addition, several general findings emerged from this…

  1. Awareness And Perception of Global Warming Among ...

    African Journals Online (AJOL)

    BACKGROUND: Increase in the emission of green house gases and the attendant climatic changes have led to the phenomenon of global warming with all its catastrophic consequences. OBJECTIVE: To assess knowledge and perception of the concept of global warming among undergraduate medical students

  2. Badminton injuries.

    Science.gov (United States)

    Krøner, K; Schmidt, S A; Nielsen, A B; Yde, J; Jakobsen, B W; Møller-Madsen, B; Jensen, J

    1990-01-01

    In a one year period, from 1 January 1986 to 31 December 1986, 4303 patients with sports injuries were treated at Aarhus Amtssygehus and Aarhus Kommunehospital. The mean age was 21.6 years (range 7-72 years) and 2830 were men. Two hundred and seventeen badminton injuries occurred in 208 patients (136 men) with a mean age of 29.6 years (range 7-57 years), constituting 4.1 percent of all sport injuries in Aarhus. Joints and ligaments were injured in 58.5 percent of the patients, most frequently located in the lower limb and significantly more often among patients younger than 30 years of age. Muscle injury occurred in 19.8 percent of the patients. This type of injury was significantly more frequent among patients older than 30 years of age. Most injuries were minor. However, 6.8 percent of the patients were hospitalized and 30.9 percent received additional treatment by a physician. As the risk of injury varies with age, attempts to plan training individually and to institute prophylactic measures should be made. PMID:2078802

  3. Efficacy of the FIFA 11+ Warm-Up Programme in Male Youth Football: A Cluster Randomised Controlled Trial

    Science.gov (United States)

    Owoeye, Oluwatoyosi B. A.; Akinbo, Sunday R. A.; Tella, Bosede A.; Olawale, Olajide A.

    2014-01-01

    The FIFA 11+ is a structured warm-up programme specially designed to prevent injuries among football players from age 14 years and above. However, studies to prove its efficacy are generally few and it is yet to be tested in male youth footballers and among African players. The purpose of the study was to examine the efficacy of the FIFA 11+ programme in reducing the risk of injuries among male youth football players of the Lagos Junior League. A cluster randomised controlled trial was conducted. All the 20 teams (414 players aged 14 -19 years) in the Premier League division were block-randomised into either an intervention (INT) or a control (CON) group. The INT group performed the FIFA 11+ exercises as warm-up during training sessions and the CON group performed usual warm-up. Participating teams were prospectively followed through an entire league season of 6 months in which they were visited every week to assess injured players for time-loss injuries in both groups. The primary outcomes were any injury to the players, injuries by type of exposure and injuries specific to the lower extremities. The secondary outcomes were injuries reported by body location, aetiology, mechanism and severity. In total, 130 injuries were recorded affecting 104 (25%) of the 416 players. Team and player compliance with the INT was 60% and 74% respectively. Based on the primary outcome measures of the study, the FIFA 11+ programme significantly reduced the overall rate of injury in the INT group by 41% [RR = 0.59 (95% CI: 0.40 – 0.86; p = 0.006)] and all lower extremity injuries by 48% [RR = 0.52 (95% CI: 0.34 – 0.82; p = 0.004)]. However, the rate of injury reduction based on secondary outcomes mostly did not reach the level of statistical significance. The FIFA 11+ programme is effective in reducing the rates of injuries in male youth football players. Key points The FIFA 11+ has only been tested in randomised controlled trials conducted on female youth football players; this

  4. Spinal injury

    Science.gov (United States)

    ... Dallas, TX: American Red Cross; 2016. Kaji AH, Newton EJ, Hockberger RS. Spinal injuries. In: Marx JA, ... member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www. ...

  5. Chilling injury

    African Journals Online (AJOL)

    ahar

    2013-12-18

    Dec 18, 2013 ... ROS avoidance genes play pivotal role in defense mechanism against chilling injury derived oxidative stress. ... Low temperature storage is a postharvest technology ..... crops is highly dependent on ethylene production and.

  6. Injury Statistics

    Science.gov (United States)

    ... Power Saws for 2001 05/15/2002 Nail Gun Related Injuries and Deaths Home Maintenance & Construction 05/ ... Information (FOIA) Inspector General No Fear Act Data USA.gov Report an Unsafe Product Contact Us: 800- ...

  7. Electrical injury

    Science.gov (United States)

    ... RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 134. Price LA, Loiacono LA. Electrical and lightning injury. In: Cameron JL, Cameron AM, eds. Current Surgical ...

  8. Ear Injury

    Science.gov (United States)

    ... of different injuries can affect the outer ear. Cauliflower ear (subperichondrial hematoma) A blunt blow to the ... to a deformed ear. This deformity, called a cauliflower ear, is common among wrestlers, boxers, and rugby ...

  9. Global warming and nuclear power

    Energy Technology Data Exchange (ETDEWEB)

    Hodgson, P.E. [Nuclear and Particle Physics Laboratory, Department of Physics, Oxford Univ., Oxford (United Kingdom)

    1999-09-01

    The concentration of carbon dioxide in the atmosphere is steadily increasing and it is widely believed that this will lead to global warming that will have serious consequences for life on earth. The Intergovernmental Panel on Climate Change has estimated that the temperature of the earth will increase by between 1 and 3.5 degrees in the next century. This will melt some of the Antarctic ice cap, raise the sea level and flood many low-lying countries, and also produce unpredictable changes in the earth's climate. The possible ways of reducing carbon dioxide emission are discussed. It is essential to reduce the burning of fossil fuels, but then how are we to obtain the energy we need? We can try to reduce energy use, but we will still need to generate large amounts energy. Some possible ways of doing this are by using wind and solar generators, by hydroelectric and tidal plants, and also by nuclear power. These possibilities will be critically examined. (author)

  10. Global warming and nuclear power

    International Nuclear Information System (INIS)

    Hodgson, P.E.

    1999-01-01

    The concentration of carbon dioxide in the atmosphere is steadily increasing and it is widely believed that this will lead to global warming that will have serious consequences for life on earth. The Intergovernmental Panel on Climate Change has estimated that the temperature of the earth will increase by between 1 and 3.5 degrees in the next century. This will melt some of the Antarctic ice cap, raise the sea level and flood many low-lying countries, and also produce unpredictable changes in the earth's climate. The possible ways of reducing carbon dioxide emission are discussed. It is essential to reduce the burning of fossil fuels, but then how are we to obtain the energy we need? We can try to reduce energy use, but we will still need to generate large amounts energy. Some possible ways of doing this are by using wind and solar generators, by hydroelectric and tidal plants, and also by nuclear power. These possibilities will be critically examined. (author)

  11. Comparing the Immediate Effects of a Total Motion Release Warm-up and a Dynamic Warm-up Protocol on the Dominant Shoulder in Baseball Athletes.

    Science.gov (United States)

    Gamma, Stephen C; Baker, Russell; May, James; Seegmiller, Jeff G; Nasypany, Alan; Iorio, Steven M

    2018-04-10

    Gamma, SC, Baker, R, May, J, Seegmiller, JG, Nasypany, A, and Iorio, SM. Comparing the immediate effects of a total motion release warm-up and a dynamic warm-up protocol on the dominant shoulder in baseball athletes. J Strength Cond Res XX(X): 000-000, 2017-A decrease in total range of motion (ROM) of the dominant shoulder may predispose baseball athletes to increased shoulder injury risk; the most effective technique for improving ROM is unknown. The purpose of this study was to compare the immediate effects of Total Motion Release (TMR) to a generic dynamic warm-up program in baseball athletes. Baseball athletes (n = 20) were randomly assigned to an intervention group: TMR group (TMRG; n = 10) or traditional warm-up group (TWG; n = 10). Shoulder ROM measurements were recorded for internal rotation (IR) and external rotation (ER), the intervention was applied, and postmeasurements were recorded. Each group then received the other intervention and postmeasurements were again recorded. The time main effect (p ≤ 0.001) and the time × group interaction effect were significant (p ≤ 0.001) for IR and ER. Post hoc analysis revealed that TMR produced significant increases in mean IR (p ≤ 0.005, d = 1.52) and ER (p ≤ 0.018, d = 1.22) of the dominant shoulder initially. When groups crossed-over, the TMRG experienced a decrease in mean IR and ER after the dynamic warm-up, whereas the TWG experienced a significant increase in mean IR (p ≤ 0.001, d = 3.08) and ER (p ≤ 0.001, d = 2.56) after TMR intervention. Total Motion Release increased IR and ER of the dominant shoulder more than a dynamic warm-up. Dynamic warm-up after TMR also resulted in decreased IR and ER; however, TMR after dynamic warm-up significantly improved IR and ER. Based on these results, TMR is more effective than a generic dynamic warm-up for improving dominant shoulder ROM in baseball players.

  12. Climatic warming destabilizes forest ant communities.

    Science.gov (United States)

    Diamond, Sarah E; Nichols, Lauren M; Pelini, Shannon L; Penick, Clint A; Barber, Grace W; Cahan, Sara Helms; Dunn, Robert R; Ellison, Aaron M; Sanders, Nathan J; Gotelli, Nicholas J

    2016-10-01

    How will ecological communities change in response to climate warming? Direct effects of temperature and indirect cascading effects of species interactions are already altering the structure of local communities, but the dynamics of community change are still poorly understood. We explore the cumulative effects of warming on the dynamics and turnover of forest ant communities that were warmed as part of a 5-year climate manipulation experiment at two sites in eastern North America. At the community level, warming consistently increased occupancy of nests and decreased extinction and nest abandonment. This consistency was largely driven by strong responses of a subset of thermophilic species at each site. As colonies of thermophilic species persisted in nests for longer periods of time under warmer temperatures, turnover was diminished, and species interactions were likely altered. We found that dynamical (Lyapunov) community stability decreased with warming both within and between sites. These results refute null expectations of simple temperature-driven increases in the activity and movement of thermophilic ectotherms. The reduction in stability under warming contrasts with the findings of previous studies that suggest resilience of species interactions to experimental and natural warming. In the face of warmer, no-analog climates, communities of the future may become increasingly fragile and unstable.

  13. Global warming and climate change: control methods

    International Nuclear Information System (INIS)

    Laal, M.; Aliramaie, A.

    2008-01-01

    This paper aimed at finding causes of global warming and ways to bring it under control. Data based on scientific opinion as given by synthesis reports of news, articles, web sites, and books. global warming is the observed and projected increases in average temperature of Earth's atmosphere and oceans. Carbon dioxide and other air pollution that is collecting in the atmosphere like a thickening blanket, trapping the sun's heat and causing the planet to warm up. Pollution is one of the biggest man-made problems. Burning fossil fuels is the main factor of pollution. As average temperature increases, habitats, species and people are threatened by drought, changes in rainfall, altered seasons, and more violent storms and floods. Indeed the life cycle of nuclear power results in relatively little pollution. Energy efficiency, solar, wind and other renewable fuels are other weapons against global warming . Human activity, primarily burning fossil fuels, is the major driving factor in global warming . Curtailing the release of carbon dioxide into the atmosphere by reducing use of oil, gasoline, coal and employment of alternate energy, sources are the tools for keeping global warming under control. global warming can be slowed and stopped, with practical actions thal yield a cleaner, healthier atmosphere

  14. Urban warming reduces aboveground carbon storage

    DEFF Research Database (Denmark)

    Meineke, Emily; Youngsteadt, Elsa; Dunn, Robert Roberdeau

    2016-01-01

    sequestration (carbon stored per year) of mature trees. Urban warming increased herbivorous arthropod abundance on trees, but these herbivores had negligible effects on tree carbon sequestration. Instead, urban warming was associated with an estimated 12% loss of carbon sequestration, in part because...... photosynthesis was reduced at hotter sites. Ecosystem service assessments that do not consider urban conditions may overestimate urban tree carbon storage. Because urban and global warming are becoming more intense, our results suggest that urban trees will sequester even less carbon in the future....

  15. An Analysis of Historical Global Warming and Social Engagement

    OpenAIRE

    Train, Joseph; Roizenman, David; Damiani, Seth; Rochwerg, Ronny

    2018-01-01

    The goal of this paper is to determine whether there is a correlation between awareness of global warming, and where global warming occurs. This theory is carried out by analyzing maps containing various forms of data that have to do with global warming, such as precipitation and surface temperature, and comparing it with a map of engagement from tweets which mention global warming. This paper found that there is no solid correlation between mentioning global warming in tweets and global warm...

  16. Studies on possibility for alleviation of lifestyle diseases by low-dose irradiation or radon inhalation

    International Nuclear Information System (INIS)

    Kataoka, T.; Sakoda, A.; Yoshimoto, M.; Nakagawa, S.; Toyota, T.; Nishiyama, Y.; Yamato, K.; Ishimori, Y.; Kawabe, A.; Hanamoto, K.; Taguchi, T.; Yamaoka, K.

    2011-01-01

    Our previous studies showed the possibility that activation of the anti-oxidative function alleviates various oxidative damages, which are related to lifestyle diseases. Results showed that, low-dose X-ray irradiation activated superoxide dismutase and inhibits oedema following ischaemia-reperfusion. To alleviate ischaemia-reperfusion injury with transplantation, the changes of the anti-oxidative function in liver graft using low-dose X-ray irradiation immediately after exenteration were examined. Results showed that liver grafts activate the anti-oxidative function as a result of irradiation. In addition, radon inhalation enhances the anti-oxidative function in some organs, and alleviates alcohol-induced oxidative damage of mouse liver. Moreover, in order to determine the most effective condition of radon inhalation, mice inhaled radon before or after carbon tetrachloride (CCl 4 ) administration. Results showed that radon inhalation alleviates CCl 4 -induced hepatopathy, especially prior inhalation. It is highly possible that adequate activation of anti-oxidative functions induced by low-dose irradiation can contribute to preventing or reducing oxidative damages, which are related to lifestyle diseases. (authors)

  17. Chest Injuries Associated with Head Injury

    African Journals Online (AJOL)

    Traumatic brain injury (TBI) is a common cause of mortality and severe morbidity. Although there have been significant advances in management, associated severe injuries, in particular chest injuries, remain a major challenge. Extracranial injuries, especially chest injuries increase mortality in patients with TBI in both short.

  18. Ecological stability in response to warming

    NARCIS (Netherlands)

    Fussmann, Katarina E.; Schwarzmueller, Florian; Brose, Ulrich; Jousset, Alexandre|info:eu-repo/dai/nl/370632656; Rall, Bjoern C.

    That species' biological rates including metabolism, growth and feeding scale with temperature is well established from warming experiments(1). The interactive influence of these changes on population dynamics, however, remains uncertain. As a result, uncertainty about ecological stability in

  19. Global temperatures and the global warming ``debate''

    Science.gov (United States)

    Aubrecht, Gordon

    2009-04-01

    Many ordinary citizens listen to pronouncements on talk radio casting doubt on anthropogenic global warming. Some op-ed columnists likewise cast doubts, and are read by credulous citizens. For example, on 8 March 2009, the Boston Globe published a column by Jeff Jacoby, ``Where's global warming?'' According to Jacoby, ``But it isn't such hints of a planetary warming trend that have been piling up in profusion lately. Just the opposite.'' He goes on to write, ``the science of climate change is not nearly as important as the religion of climate change,'' and blamed Al Gore for getting his mistaken views accepted. George Will at the Washington Post also expressed denial. As a result, 44% of U.S. voters, according to the January 19 2009 Rasmussen Report, blame long-term planetary trends for global warming, not human beings. Is there global cooling, as skeptics claim? We examine the temperature record.

  20. Global Surface Warming Hiatus Analysis Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data were used to conduct the study of the global surface warming hiatus, an apparent decrease in the upward trend of global surface temperatures since 1998....

  1. A review of warm mix asphalt.

    Science.gov (United States)

    2008-12-01

    Warm Mix Asphalt (WMA) technology, recently developed in Europe, is gaining strong interest in the US. By : lowering the viscosity of asphalt binder and/or increasing the workability of mixture using minimal heat, WMA : technology allows the mixing, ...

  2. Effects of global warming on respiratory diseases

    African Journals Online (AJOL)

    Abe Olugbenga

    and tuberculosis), parasitic lung diseases, chronic obstructive pulmonary disease ... Methods: A literature search on global warming and respiratory diseases was carried out through the internet .... (COPD) The main factor to consider here is.

  3. Teaching cases on transportation and global warming.

    Science.gov (United States)

    2013-03-01

    This project developed a series of three teaching cases that explore the implications of global : warming for transportation policy in the United States. The cases are intended to be used in : graduate and undergraduate courses on transportation poli...

  4. Self-interacting warm dark matter

    International Nuclear Information System (INIS)

    Hannestad, Steen; Scherrer, Robert J.

    2000-01-01

    It has been shown by many independent studies that the cold dark matter scenario produces singular galactic dark halos, in strong contrast with observations. Possible remedies are that either the dark matter is warm so that it has significant thermal motion or that the dark matter has strong self-interactions. We combine these ideas to calculate the linear mass power spectrum and the spectrum of cosmic microwave background (CMB) fluctuations for self-interacting warm dark matter. Our results indicate that such models have more power on small scales than is the case for the standard warm dark matter model, with a CMB fluctuation spectrum which is nearly indistinguishable from standard cold dark matter. This enhanced small-scale power may provide better agreement with the observations than does standard warm dark matter. (c) 2000 The American Physical Society

  5. Reconciling controversies about the 'global warming hiatus'.

    Science.gov (United States)

    Medhaug, Iselin; Stolpe, Martin B; Fischer, Erich M; Knutti, Reto

    2017-05-03

    Between about 1998 and 2012, a time that coincided with political negotiations for preventing climate change, the surface of Earth seemed hardly to warm. This phenomenon, often termed the 'global warming hiatus', caused doubt in the public mind about how well anthropogenic climate change and natural variability are understood. Here we show that apparently contradictory conclusions stem from different definitions of 'hiatus' and from different datasets. A combination of changes in forcing, uptake of heat by the oceans, natural variability and incomplete observational coverage reconciles models and data. Combined with stronger recent warming trends in newer datasets, we are now more confident than ever that human influence is dominant in long-term warming.

  6. Abrupt warming of the Red Sea

    KAUST Repository

    Raitsos, D. E.; Hoteit, Ibrahim; Prihartato, Perdana; Chronis, T.; Triantafyllou, G.; Abualnaja, Y.

    2011-01-01

    marine temperature. The comparisons with Northern Hemisphere temperatures revealed that the observed warming is part of global climate change trends. The hitherto results also raise additional questions regarding other broader climatic impacts over

  7. Global warming and north-south solidarity

    International Nuclear Information System (INIS)

    Islam, S.

    1998-01-01

    The discussion on climate change is based on 'contradictory certainties'. All sides claim to have found the truth. Much has been written and said about the connection between global warming, biodiversity and over population. The impoverished countries of the South se the insatiable intentions of the North as the major threat to the environment; and global warming as an excuse for stopping the economic development of the south

  8. Attribution of polar warming to human influence

    OpenAIRE

    Gillett, NP; Stone, DA; Stott, PA; Nozawa, T; Karpechko, AY; Hegerl, GC; Wehner, MF; Jones, PD

    2008-01-01

    The polar regions have long been expected to warm strongly as a result of anthropogenic climate change, because of the positive feedbacks associated with melting ice and snow. Several studies have noted a rise in Arctic temperatures over recent decades, but have not formally attributed the changes to human influence, owing to sparse observations and large natural variability. Both warming and cooling trends have been observed in Antarctica, which the Intergovernmental Panel on Climate Change ...

  9. Scaling Potential Evapotranspiration with Greenhouse Warming (Invited)

    Science.gov (United States)

    Scheff, J.; Frierson, D. M.

    2013-12-01

    Potential evapotranspiration (PET) is a supply-independent measure of the evaporative demand of a terrestrial climate, of basic importance in climatology, hydrology, and agriculture. Future increases in PET from greenhouse warming are often cited as key drivers of global trends toward drought and aridity. The present work computes recent and business-as-usual-future Penman-Monteith (i.e. physically-based) PET fields at 3-hourly resolution in 14 modern global climate models. The %-change in local annual-mean PET over the upcoming century is almost always positive, modally low double-digit in magnitude, usually increasing with latitude, yet quite divergent between models. These patterns are understood as follows. In every model, the global field of PET %-change is found to be dominated by the direct, positive effects of constant-relative-humidity warming (via increasing vapor pressure deficit and increasing Clausius-Clapeyron slope.) This direct-warming term very accurately scales as the PET-weighted (warm-season daytime) local warming, times 5-6% per degree (related to the Clausius-Clapeyron equation), times an analytic factor ranging from about 0.25 in warm climates to 0.75 in cold climates, plus a small correction. With warming of several degrees, this product is of low double-digit magnitude, and the strong temperature dependence gives the latitude dependence. Similarly, the inter-model spread in the amount of warming gives most of the spread in this term. Additional spread in the total change comes from strong disagreement on radiation, relative-humidity, and windspeed changes, which make smaller yet substantial contributions to the full PET %-change fields.

  10. Mediterranean climate change and Indian Ocean warming

    International Nuclear Information System (INIS)

    Hoerling, M.; Eischeid, J.; Hurrel, J.

    2006-01-01

    General circulation model (GCM) responses to 20. century changes in sea surface temperatures (SSTs) and greenhouse gases are diagnosed, with emphasis on their relationship to observed regional climate change over the Mediterranean region. A major question is whether the Mediterranean region's drying trend since 1950 can be understood as a consequence of the warming trend in tropical SSTs. We focus on the impact of Indian Ocean warming, which is itself the likely result of increasing greenhouse gases. It is discovered that a strong projection onto the positive polarity of the North Atlantic Oscillation (NAO) index characterizes the atmospheric response structure to the 1950-1999 warming of Indian Ocean SSTs. This influence appears to be robust in so far as it is reproduced in ensembles of experiments using three different GCMs. Both the equilibrium and transient responses to Indian Ocean warming are examined. Under each scenario, the latitude of prevailing mid latitude westerlies shifts poleward during the November-April period. The consequence is a drying of the Mediterranean region, whereas northern Europe and Scandinavia receive increased precipitation in concert with the poleward shift of storminess. The IPCC (TAR) 20. century coupled ocean-atmosphere simulations forced by observed greenhouse gas changes also yield a post-1950 drying trend over the Mediterranean. We argue that this feature of human-induced regional climate change is the outcome of a dynamical feedback, one involving Indian Ocean warming and a requisite adjustment of atmospheric circulation systems to such ocean warming

  11. Global warming and nuclear power

    Energy Technology Data Exchange (ETDEWEB)

    Wood, L., LLNL

    1998-07-10

    -fold reduction might be attained. Even the first such halving of carbon intensivity of stationary-source energy production world-wide might permit continued slow power-demand growth in the highly developed countries and rapid development of the other 80% of the world, both without active governmental suppression of fossil fuel usage - while also stabilizing carbon input-rates into the Earth`s atmosphere. The second two-fold reduction might obviate most global warming concerns.

  12. The importance of warm season warming to western U.S. streamflow changes

    Science.gov (United States)

    Das, T.; Pierce, D.W.; Cayan, D.R.; Vano, J.A.; Lettenmaier, D.P.

    2011-01-01

    Warm season climate warming will be a key driver of annual streamflow changes in four major river basins of the western U.S., as shown by hydrological model simulations using fixed precipitation and idealized seasonal temperature changes based on climate projections with SRES A2 forcing. Warm season (April-September) warming reduces streamflow throughout the year; streamflow declines both immediately and in the subsequent cool season. Cool season (October-March) warming, by contrast, increases streamflow immediately, partially compensating for streamflow reductions during the subsequent warm season. A uniform warm season warming of 3C drives a wide range of annual flow declines across the basins: 13.3%, 7.2%, 1.8%, and 3.6% in the Colorado, Columbia, Northern and Southern Sierra basins, respectively. The same warming applied during the cool season gives annual declines of only 3.5%, 1.7%, 2.1%, and 3.1%, respectively. Copyright 2011 by the American Geophysical Union.

  13. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Spinal Cord Injury Facts and Figures Care and Treatment After SCI Spinal Cord Injury Rehabilitation Pediatric Spinal ... Spinal Cord Injury Facts and Figures Care and Treatment After SCI Spinal Cord Injury Rehabilitation Pediatric Spinal ...

  14. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Cord Injury Rehabilitation Pediatric Spinal Cord Injuries Video Library SCI Medical Experts People Living with SCI Personal ... Cord Injury Rehabilitation Pediatric Spinal Cord Injuries Video Library SCI Medical Experts People Living with SCI Personal ...

  15. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Cord Injury Diane M. Rowles, MS, NP How Family Life Changes After Spinal Cord Injury Nancy Rosenberg, ... Children with Spinal Cord Injury Patricia Mucia, RN Family Life After Pediatric Spinal Injury Dawn Sheaffer, MSW ...

  16. Dealing with Sports Injuries

    Science.gov (United States)

    ... Videos for Educators Search English Español Dealing With Sports Injuries KidsHealth / For Teens / Dealing With Sports Injuries ... a long way toward preventing injuries. Types of Sports Injuries Common reasons why teens get injured playing ...

  17. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Animated Spinal Cord Injury Chart Spinal Cord Injury Facts and Figures Care and Treatment After SCI Spinal ... Animated Spinal Cord Injury Chart Spinal Cord Injury Facts and Figures Care and Treatment After SCI Spinal ...

  18. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Topic Resources Peer Counseling Blog About Media Donate Spinal Cord Injury Medical Expert Videos Topics menu Topics Spinal Cord Injury 101 Adult Injuries Spinal Cord Injury 101 David ...

  19. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Topic Resources Peer Counseling Blog About Media Donate Spinal Cord Injury Medical Expert Videos Topics menu Topics Spinal Cord Injury 101 Adult Injuries Spinal Cord Injury 101 ...

  20. The administration of renoprotective agents extends warm ischemia in a rat model.

    Science.gov (United States)

    Cohen, Jacob; Dorai, Thambi; Ding, Cheng; Batinic-Haberle, Ines; Grasso, Michael

    2013-03-01

    Extended warm ischemia time during partial nephrectomy leads to considerable renal injury. Using a rat model of renal ischemia, we examined the ability of a unique renoprotective cocktail to ameliorate warm ischemia-reperfusion injury and extend warm ischemia time. A warm renal ischemia model was developed using Sprague-Dawley rats, clamping the left renal artery for 40, 50, 60, and 70 minutes, followed by 48 hours of reperfusion. An improved renoprotective cocktail referred to as I-GPM (a mixture of specific renoprotective growth factors, porphyrins, and mitochondria-protecting amino acids) was administered -24 hours, 0 hours, and +24 hours after surgery. At 48 hours, both kidneys were harvested and examined with hematoxylin and eosin and periodic acid-Schiff stains for the analysis of renal tubular necrosis. Creatinine, protein, and gene expression levels were also analyzed to evaluate several ischemia-specific and antioxidant response markers. I-GPM treated kidneys showed significant reversal of morphologic changes and a significant reduction in specific ischemic markers lipocalin-2, galectin-3, GRP-78, and HMGB1 compared with ischemic controls. These experiments also showed an upregulation of the stress response protein, heat shock protein (HSP)-70, as well as the phosphorylated active form of the transcription factor, heat shock factor (HSF)-1. In addition, quantitative RT-PCR analyses revealed a robust upregulation of several antioxidant pathway response genes in I-GPM treated animals. By histopathologic and several molecular measures, our unique renoprotective cocktail mitigated ischemia-reperfusion injury. Our cocktail minimized oxidative stress in an ischemic kidney rat model while at the same time protecting the global parenchymal function during extended periods of ischemia.

  1. Joint-position sense is altered by football pre-participation warm-up exercise and match induced fatigue.

    Science.gov (United States)

    Salgado, Eduardo; Ribeiro, Fernando; Oliveira, José

    2015-06-01

    The demands to which football players are exposed during the match may augment the risk of injury by decreasing the sense of joint position. This study aimed to assess the effect of pre-participation warm-up and fatigue induced by an official football match on the knee-joint-position sense of football players. Fourteen semi-professional male football players (mean age: 25.9±4.6 years old) volunteered in this study. The main outcome measures were rate of perceived exertion and knee-joint-position sense assessed at rest, immediately after a standard warm-up (duration 25 min), and immediately after a competitive football match (90 minutes duration). Perceived exertion increased significantly from rest to the other assessments (rest: 8.6±2.0; after warm-up: 12.1±2.1; after football match: 18.5±1.3; pfootball match compared to both rest (pfootball match-induced fatigue. Warm-up exercises could contribute to knee injury prevention, whereas the deleterious effect of match-induced fatigue on the sensorimotor system could ultimately contribute to knee instability and injury. Copyright © 2014 Elsevier B.V. All rights reserved.

  2. The effect of warm-up, static stretching and dynamic stretching on hamstring flexibility in previously injured subjects

    Directory of Open Access Journals (Sweden)

    Murray Elaine

    2009-04-01

    Full Text Available Abstract Background Warm-up and stretching are suggested to increase hamstring flexibility and reduce the risk of injury. This study examined the short-term effects of warm-up, static stretching and dynamic stretching on hamstring flexibility in individuals with previous hamstring injury and uninjured controls. Methods A randomised crossover study design, over 2 separate days. Hamstring flexibility was assessed using passive knee extension range of motion (PKE ROM. 18 previously injured individuals and 18 uninjured controls participated. On both days, four measurements of PKE ROM were recorded: (1 at baseline; (2 after warm-up; (3 after stretch (static or dynamic and (4 after a 15-minute rest. Participants carried out both static and dynamic stretches, but on different days. Data were analysed using Anova. Results Across both groups, there was a significant main effect for time (p 0.05. Using ANCOVA to adjust for the non-significant (p = 0.141 baseline difference between groups, the previously injured group demonstrated a greater response to warm-up and static stretching, however this was not statistically significant (p = 0.05. Conclusion Warm-up significantly increased hamstring flexibility. Static stretching also increased hamstring flexibility, whereas dynamic did not, in agreement with previous findings on uninjured controls. The effect of warm-up and static stretching on flexibility was greater in those with reduced flexibility post-injury, but this did not reach statistical significance. Further prospective research is required to validate the hypothesis that increased flexibility improves outcomes. Trial Registration ACTRN12608000638336

  3. Fingertip Injuries

    Science.gov (United States)

    ... All Topics A-Z Videos Infographics Symptom Picker Anatomy Bones Joints Muscles Nerves Vessels Tendons About Hand Surgery What is a Hand Surgeon? What is a Hand Therapist? Media Find a Hand Surgeon Home Anatomy Fingertip Injury Email to a friend * required fields ...

  4. Musculoskeletal injuries

    International Nuclear Information System (INIS)

    Gigirey, V

    2012-01-01

    This presentation is about musculoskeletal injuries and the diagnosis of osseous tumors. The use of the radiology, bone scintigraphy, computed tomography and magnetic resonance contribute to detect the localization of the osseous lesions as well as the density (lytic, sclerotic, mixed) and the benign and malignant tumors.

  5. Can Global Warming be Stopped?

    Science.gov (United States)

    Luria, M.

    2013-12-01

    Earlier this year, the CO2 levels exceeded the 400 ppm level and there is no sign that the 1-2 ppm annual increase is going to slow down. Concerns regarding the danger of global warming have been reported in numerous occasions for more than a generation, ever since CO2 levels reached the 350 ppm range in the mid 1980's. Nevertheless, all efforts to slow down the increase have showed little if any effect. Mobile sources, including surface and marine transportation and aviation, consist of 20% of the global CO2 emission. The only realistic way to reduce the mobile sources' CO2 signature is by improved fuel efficiency. However, any progress in this direction is more than compensated by continuous increased demand. Stationary sources, mostly electric power generation, are responsible for the bulk of the global CO2 emission. The measurements have shown, that the effect of an increase in renewable sources, like solar wind and geothermal, combined with conversion from coal to natural gas where possible, conservation and efficiency improvement, did not compensate the increased demand mostly in developing countries. Increased usage of nuclear energy can provide some relief in carbon emission but has the potential of even greater environmental hazard. A major decrease in carbon emission can be obtained by either significant reduction in the cost of non-carbon based energy sources or by of carbon sequestration. The most economical way to make a significant decrease in carbon emission is to apply carbon sequestration technology at large point sources that use coal. Worldwide there are about 10,000 major sources that burn >7 billion metric tons of coal which generate the equivalent of 30 trillion kwh. There is a limited experience in CO2 sequestration of such huge quantities of CO2, however, it is estimated that the cost would be US$ 0.01-0.1 per kwh. The cost of eliminating this quantity can be estimated at an average of 1.5 trillion dollars annually. The major emitters, US

  6. Efficacy of the FIFA 11+ Warm-Up Programme in Male Youth Football: A Cluster Randomised Controlled Trial

    Directory of Open Access Journals (Sweden)

    Oluwatoyosi B. A. Owoeye

    2014-06-01

    Full Text Available The FIFA 11+ is a structured warm-up programme specially designed to prevent injuries among football players from age 14 years and above. However, studies to prove its efficacy are generally few and it is yet to be tested in male youth footballers and among African players. The purpose of the study was to examine the efficacy of the FIFA 11+ programme in reducing the risk of injuries among male youth football players of the Lagos Junior League. A cluster randomised controlled trial was conducted. All the 20 teams (414 players aged 14 -19 years in the Premier League division were block-randomised into either an intervention (INT or a control (CON group. The INT group performed the FIFA 11+ exercises as warm-up during training sessions and the CON group performed usual warm-up. Participating teams were prospectively followed through an entire league season of 6 months in which they were visited every week to assess injured players for time-loss injuries in both groups. The primary outcomes were any injury to the players, injuries by type of exposure and injuries specific to the lower extremities. The secondary outcomes were injuries reported by body location, aetiology, mechanism and severity. In total, 130 injuries were recorded affecting 104 (25% of the 416 players. Team and player compliance with the INT was 60% and 74% respectively. Based on the primary outcome measures of the study, the FIFA 11+ programme significantly reduced the overall rate of injury in the INT group by 41% [RR = 0.59 (95% CI: 0.40 – 0.86; p = 0.006] and all lower extremity injuries by 48% [RR = 0.52 (95% CI: 0.34 – 0.82; p = 0.004]. However, the rate of injury reduction based on secondary outcomes mostly did not reach the level of statistical significance. The FIFA 11+ programme is effective in reducing the rates of injuries in male youth football players.

  7. Warm Absorber Diagnostics of AGN Dynamics

    Science.gov (United States)

    Kallman, Timothy

    Warm absorbers and related phenomena are observable manifestations of outflows or winds from active galactic nuclei (AGN) that have great potential value. Understanding AGN outflows is important for explaining the mass budgets of the central accreting black hole, and also for understanding feedback and the apparent co-evolution of black holes and their host galaxies. In the X-ray band warm absorbers are observed as photoelectric absorption and resonance line scattering features in the 0.5-10 keV energy band; the UV band also shows resonance line absorption. Warm absorbers are common in low luminosity AGN and they have been extensively studied observationally. They may play an important role in AGN feedback, regulating the net accretion onto the black hole and providing mechanical energy to the surroundings. However, fundamental properties of the warm absorbers are not known: What is the mechanism which drives the outflow?; what is the gas density in the flow and the geometrical distribution of the outflow?; what is the explanation for the apparent relation between warm absorbers and the surprising quasi-relativistic 'ultrafast outflows' (UFOs)? We propose a focused set of model calculations that are aimed at synthesizing observable properties of warm absorber flows and associated quantities. These will be used to explore various scenarios for warm absorber dynamics in order to answer the questions in the previous paragraph. The guiding principle will be to examine as wide a range as possible of warm absorber driving mechanisms, geometry and other properties, but with as careful consideration as possible to physical consistency. We will build on our previous work, which was a systematic campaign for testing important class of scenarios for driving the outflows. We have developed a set of tools that are unique and well suited for dynamical calculations including radiation in this context. We also have state-of-the-art tools for generating synthetic spectra, which are

  8. Global warming from an energy perspective

    International Nuclear Information System (INIS)

    Edwards, A.G.

    1991-01-01

    Global climate change and energy are integrally related. The majority of greenhouse gas emissions are the result of energy production and use; at the same time, warming will affect energy patterns in California through physical increases in energy demand, physical changes in energy supply, and changes in both energy end-use patterns and supplies resulting from climate-change policies. There seems to be a growing political consensus that the world (as well as the state) needs to act soon to minimize further commitment to future warming. While California is not likely to experience the physical changes resulting from a warmer climate for years or perhaps decades, policy responses to the warming issue may cause more immediate impacts. This chapter will discuss how policy response to potential warming may be the most significant early impact of the issue on California's energy system. Makers of energy policy face the dilemma of deciding how to respond to the climate warming issue in the face of scientific uncertainties about its timing and seriousness. The chapter will conclude by presenting a conceptual framework for dealing with this dilemma, along with general recommendations for action

  9. Global warming without global mean precipitation increase?

    Science.gov (United States)

    Salzmann, Marc

    2016-06-01

    Global climate models simulate a robust increase of global mean precipitation of about 1.5 to 2% per kelvin surface warming in response to greenhouse gas (GHG) forcing. Here, it is shown that the sensitivity to aerosol cooling is robust as well, albeit roughly twice as large. This larger sensitivity is consistent with energy budget arguments. At the same time, it is still considerably lower than the 6.5 to 7% K(-1) decrease of the water vapor concentration with cooling from anthropogenic aerosol because the water vapor radiative feedback lowers the hydrological sensitivity to anthropogenic forcings. When GHG and aerosol forcings are combined, the climate models with a realistic 20th century warming indicate that the global mean precipitation increase due to GHG warming has, until recently, been completely masked by aerosol drying. This explains the apparent lack of sensitivity of the global mean precipitation to the net global warming recently found in observations. As the importance of GHG warming increases in the future, a clear signal will emerge.

  10. Global warming: Towards a strategy for Ontario

    International Nuclear Information System (INIS)

    1990-01-01

    A discussion paper is provided as background to a proposed public review of a strategy for Ontario's response to global warming. Global warming arises from the generation of greenhouse gases, which come from the use of fossil fuels, the use of chlorofluorocarbons, and deforestation. Energy policy is the backbone of achieving climate stability since the burning of fossil fuels releases most of the greenhouse gases, mainly carbon dioxide. Canada is, by international standards, a very energy-intensive country and is among the world's largest emitters of carbon dioxide on a per capita basis. Ontario is the largest energy-using province in Canada, and fossil fuels represent over 80% of provincial energy use. A proposed goal for Ontario is to provide leadership in stabilizing atmospheric concentrations of the greenhouse gases, while minimizing the social, economic, and environmental costs in Ontario of adapting to global warming. A proposed first step to address global warming is to achieve reductions in expected emissions of the greenhouse gases, especially carbon dioxide, so that levels by the year 2000 are lower than in 1989. Current policies and regulations helping to reduce the greenhouse effect include some of the current controls on automotive emissions and the adoption by the provincial electric utility of targets to reduce electricity demand. New initiatives include establishment of minimum energy efficiency standards and reduction of peak-day electricity use. Action steps for future consideration are detailed in the categories of greenhouse gas emissions reductions, carbon dioxide absorption, and research and analysis into global warming

  11. Thyroid storm and warm autoimmune hemolytic anemia.

    Science.gov (United States)

    Moore, Joseph A; Gliga, Louise; Nagalla, Srikanth

    2017-08-01

    Graves' disease is often associated with other autoimmune disorders, including rare associations with autoimmune hemolytic anemia (AIHA). We describe a unique presentation of thyroid storm and warm AIHA diagnosed concurrently in a young female with hyperthyroidism. The patient presented with nausea, vomiting, diarrhea and altered mental status. Laboratory studies revealed hemoglobin 3.9g/dL, platelets 171×10 9 L -1 , haptoglobin storm and warm AIHA. She was started on glucocorticoids to treat both warm AIHA and thyroid storm, as well as antithyroid medications, propranolol and folic acid. Due to profound anemia and hemodynamic instability, the patient was transfused two units of uncrossmatched packed red blood cells slowly and tolerated this well. She was discharged on methimazole as well as a prolonged prednisone taper, and achieved complete resolution of the thyrotoxicosis and anemia at one month. Hyperthyroidism can affect all three blood cell lineages of the hematopoietic system. Anemia can be seen in 10-20% of patients with thyrotoxicosis. Several autoimmune processes can lead to anemia in Graves' disease, including pernicious anemia, celiac disease, and warm AIHA. This case illustrates a rarely described presentation of a patient with Graves' disease presenting with concurrent thyroid storm and warm AIHA. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. The effect of warm-up, static stretching and dynamic stretching on hamstring flexibility in previously injured subjects.

    LENUS (Irish Health Repository)

    O'Sullivan, Kieran

    2009-01-01

    BACKGROUND: Warm-up and stretching are suggested to increase hamstring flexibility and reduce the risk of injury. This study examined the short-term effects of warm-up, static stretching and dynamic stretching on hamstring flexibility in individuals with previous hamstring injury and uninjured controls. METHODS: A randomised crossover study design, over 2 separate days. Hamstring flexibility was assessed using passive knee extension range of motion (PKE ROM). 18 previously injured individuals and 18 uninjured controls participated. On both days, four measurements of PKE ROM were recorded: (1) at baseline; (2) after warm-up; (3) after stretch (static or dynamic) and (4) after a 15-minute rest. Participants carried out both static and dynamic stretches, but on different days. Data were analysed using Anova. RESULTS: Across both groups, there was a significant main effect for time (p < 0.001). PKE ROM significantly increased with warm-up (p < 0.001). From warm-up, PKE ROM further increased with static stretching (p = 0.04) but significantly decreased after dynamic stretching (p = 0.013). The increased flexibility after warm-up and static stretching reduced significantly (p < 0.001) after 15 minutes of rest, but remained significantly greater than at baseline (p < 0.001). Between groups, there was no main effect for group (p = 0.462), with no difference in mean PKE ROM values at any individual stage of the protocol (p > 0.05). Using ANCOVA to adjust for the non-significant (p = 0.141) baseline difference between groups, the previously injured group demonstrated a greater response to warm-up and static stretching, however this was not statistically significant (p = 0.05). CONCLUSION: Warm-up significantly increased hamstring flexibility. Static stretching also increased hamstring flexibility, whereas dynamic did not, in agreement with previous findings on uninjured controls. The effect of warm-up and static stretching on flexibility was greater in those with reduced

  13. Evaluation of the warm-up habits and knowledge levels in amateur athletes

    Directory of Open Access Journals (Sweden)

    Hasan Aykut Aysan

    2011-06-01

    Full Text Available The aim of this study was to evaluate the warm-up habit and level of knowledge in the amateur athletes.Materials and methods: A total of 510 amateur athletes aged between 17 and 30 years with the mean sport age of 6.2±3.4 years were included. There were 360 males (mean age 22.4±2.0 years and 150 females (mean age 21.2±2.1 years. Warm-up habits of athletes were obtained using by the Likert-type survey questionnaire consisting of 20 questions. The reliability coefficient of the survey had been calculated as cronbach alph=0.647, KMO=0.715, Barlett=1968.711 (p<0.05.Results: It was observed that 56.3% of the athletes had sportive success in elite level and 25% of the male athletes and 32% of the female athletes had never injured before. Item of “warm-up has no effect on the performance of the athlete” was rejected with the mean score of 2.70±0.93, item of “warm-up lessens the risk of being injured for the athletes” was accepted by majority (83.9%. Of all athletes, 83.9% of them had been injured more than once. The warm-up habit was found to be performed in 47.8% at pre-training or pre-competition periods, however cool-down habit was found in 17.3% of athletes at the end of activity.Conclusion: There was a common belief that warm-up had a positive effect on the performance of the athletes, reduced the risk of injury, increased the movement angle of joints. But it can be said that habits of the amateurs was not at a sufficient level. J Clin Exp Invest 2011;2(2:181-6

  14. Developmental and physiological challenges of octopus (Octopus vulgaris) early life stages under ocean warming.

    Science.gov (United States)

    Repolho, Tiago; Baptista, Miguel; Pimentel, Marta S; Dionísio, Gisela; Trübenbach, Katja; Lopes, Vanessa M; Lopes, Ana Rita; Calado, Ricardo; Diniz, Mário; Rosa, Rui

    2014-01-01

    The ability to understand and predict the effects of ocean warming (under realistic scenarios) on marine biota is of paramount importance, especially at the most vulnerable early life stages. Here we investigated the impact of predicted environmental warming (+3 °C) on the development, metabolism, heat shock response and antioxidant defense mechanisms of the early stages of the common octopus, Octopus vulgaris. As expected, warming shortened embryonic developmental time by 13 days, from 38 days at 18 °C to 25 days at 21 °C. Concomitantly, survival decreased significantly (~29.9 %). Size at hatching varied inversely with temperature, and the percentage of smaller premature paralarvae increased drastically, from 0 % at 18 °C to 17.8 % at 21 °C. The metabolic costs of the transition from an encapsulated embryo to a free planktonic form increased significantly with warming, and HSP70 concentrations and glutathione S-transferase activity levels were significantly magnified from late embryonic to paralarval stages. Yet, despite the presence of effective antioxidant defense mechanisms, ocean warming led to an augmentation of malondialdehyde levels (an indicative of enhanced ROS action), a process considered to be one of the most frequent cellular injury mechanisms. Thus, the present study provides clues about how the magnitude and rate of ocean warming will challenge the buffering capacities of octopus embryos and hatchlings' physiology. The prediction and understanding of the biochemical and physiological responses to warmer temperatures (under realistic scenarios) is crucial for the management of highly commercial and ecologically important species, such as O. vulgaris.

  15. Nerve injury caused by mandibular block analgesia

    DEFF Research Database (Denmark)

    Hillerup, S; Jensen, Rigmor H

    2006-01-01

    Fifty-four injection injuries in 52 patients were caused by mandibular block analgesia affecting the lingual nerve (n=42) and/or the inferior alveolar nerve (n=12). All patients were examined with a standardized test of neurosensory functions. The perception of the following stimuli was assessed......: feather light touch, pinprick, sharp/dull discrimination, warm, cold, point location, brush stroke direction, 2-point discrimination and pain perception. Gustation was tested for recognition of sweet, salt, sour and bitter. Mandibular block analgesia causes lingual nerve injury more frequently than...... inferior alveolar nerve injury. All grades of loss of neurosensory and gustatory functions were found, and a range of persisting neurogenic malfunctions was reported. Subjective complaints and neurosensory function tests indicate that lingual nerve lesions are more incapacitating than inferior alveolar...

  16. Studies of global warming and global energy

    International Nuclear Information System (INIS)

    Inaba, Atsushi

    1993-01-01

    Global warming caused by increase in atmospheric CO 2 concentration has been the focus of many recent global energy studies. CO 2 is emitted to the atmosphere mainly from the combustion of fossil fuels. This means that global warming is fundamentally a problem of the global energy system. An analysis of the findings of recent global energy studies is made in this report. The results are categorized from the viewpoint of concern about global warming. The analysis includes energy use and CO 2 emissions, measures taken to restrain CO 2 emissions and the cost of such measure, and suggestions for long term global energy generation. Following this comparative analysis, each of the studies is reviewed in detail. (author) 63 refs

  17. The impacts and costs of global warming

    International Nuclear Information System (INIS)

    Eyre, N.J.

    1991-01-01

    There is now a scientific consensus that current rates of accumulation of greenhouses gases in the atmosphere will result in significant global warming and climate change. These changes are likely to have important impacts on a wide range of human activities and the natural environment. There has now been a considerable weight of literature published on the impacts of global warming, much of it very recent. This report seeks to summarise the important results, to analyse the uncertainties and to make a preliminary analysis of the feasibility of monetarising these environmental costs. The impacts of global warming are divided into ten major categories: agriculture, forests and forestry, terrestrial ecosystems and biodiversity, hydrology and water resources, sea level rise and coastal zones, energy, infrastructure/transport/industry, human health and air quality, oceans, and cryospheric impacts. The results of major summary reports are analysed, notably the report of Working Group II of the Intergovernmental Panel on Climate Change (the IPCC). (author)

  18. Exercise Science Principles and the Vocal Warm-up: Implications for Singing Voice Pedagogy.

    Science.gov (United States)

    Hoch, Matthew; Sandage, Mary J

    2018-01-01

    Principles from exercise science literature were applied to singing warm-up pedagogy as a method for examining parallels between athletic and voice training. Analysis of the use of exercise principles in vocal warm-up should illuminate aspects of voice training that may be further developed in the future. A selected canon of standard voice pedagogy texts and well-regarded warm-up methods were evaluated for use of exercise science principles for skill acquisition and fatigue resistance. Exercises were then categorized according to whether they were used for the purpose of skill acquisition (specificity), training up to tasks (overload), or detraining (reversibility). A preliminary review of well-established voice pedagogy programs reveals a strong bias toward the skill acquisition aspects of vocal warm-up, with little commentary on the fatigue management aspects. Further, the small number of vocalises examined that are not skill-acquisition oriented fall into a third "habilitative" category that likewise does not relate to overload but may play a role in offsetting reversibility. Although a systematic pedagogy for skill acquisition has emerged in the literature and practice of voice pedagogy, a parallel pedagogy for fatigue management has yet to be established. Identification of a systematic pedagogy for training up to specific singing genres and development of a singing maintenance program to avoid detraining may help the singer avoid injury. Copyright © 2018 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  19. Warm Inflation with Nonminimal Derivative Coupling

    International Nuclear Information System (INIS)

    Rashidi, N.; Nozari, Kourosh; Shoukrani, M.

    2014-01-01

    We study the effects of the nonminimal derivative coupling on the dissipative dynamics of the warm inflation where the scalar field is nonminimally coupled to gravity via its kinetic term. We present a detailed calculation of the cosmological perturbations in this setup. We use the recent observational data from the joint data set of WMAP9 + BAO + H 0 and also the Planck satellite data to constrain our model parameters for natural and chaotic inflation potentials. We study also the levels of non-Gaussianity in this warm inflation model and we confront the result with recent observational data from the Planck satellite

  20. Is the enhancement of global warming important?

    International Nuclear Information System (INIS)

    Symons, M.C.R.; Barrett, J.

    2001-01-01

    There is no doubt that global warming is important; without it the Earth's surface would have a mean temperature of 33 o C lower than it has currently. The IPCC maintains that human activities are to blame for the observed increase in the concentration of carbon dioxide in the atmosphere since pre-industrial times. There are some doubts about whether global warming is being enhanced by the activities of the human race. This article reviews these doubts and the proposed remedies to the alleged enhancement. (author)

  1. Methane Cycling in a Warming Wetland

    Science.gov (United States)

    Noyce, G. L.; Megonigal, P.; Rich, R.; Kirwan, M. L.; Herbert, E. R.

    2017-12-01

    Coastal wetlands are global hotspots of carbon (C) storage, but the future of these systems is uncertain. In June 2016, we initiated an in-situ, active, whole-ecosystem warming experiment in the Smithsonian's Global Change Research Wetland to quantify how warming and elevated CO2 affect the stability of coastal wetland soil C pools and contemporary rates of C sequestration. Transects are located in two plant communities, dominated by C3 sedges or C4 grasses. The experiment has a gradient design with air and soil warming treatments ranging from ambient to +5.1 °C and heated plots consistently maintain their target temperature year-round. In April 2017, an elevated CO2 treatment was crossed with temperature in the C3community. Ongoing measurements include soil elevation, C fluxes, porewater chemistry and redox potential, and above- and below-ground growth and biomass. In both years, warming increased methane (CH4) emissions (measured at 3-4 week intervals) from spring through fall at the C3 site, but had little effect on emissions from the C4 site. Winter (Dec-Mar) emissions showed no treatment effect. Stable isotope analysis of dissolved CH4 and DIC also indicated that warming had differing effects on CH4 pathways in the two vegetation communities. To better understand temperature effects on rates of CH4 production and oxidation, 1 m soil cores were collected from control areas of the marsh in summer 2017 and incubated at temperatures ranging from 4 °C to 35 °C. Warming increased CH4 production and oxidation rates in surface samples and oxidation rates in the rooting zone samples from both sites, but temperature responses in deep (1 m) soil samples were minimal. In the surface and rooting zone samples, production rates were also consistently higher in C3 soils compared to C4 soils, but, contrary to our expectations, the temperature response was stronger in the C4 soils. However, oxidation in C3 rooting zone samples did have a strong temperature response. The

  2. Forecasting effects of global warming on biodiversity

    DEFF Research Database (Denmark)

    Botkin, D.B.; Saxe, H.; Araújo, M.B.

    2007-01-01

    The demand for accurate forecasting of the effects of global warming on biodiversity is growing, but current methods for forecasting have limitations. In this article, we compare and discuss the different uses of four forecasting methods: (1) models that consider species individually, (2) niche...... and theoretical ecological results suggest that many species could be at risk from global warming, during the recent ice ages surprisingly few species became extinct. The potential resolution of this conundrum gives insights into the requirements for more accurate and reliable forecasting. Our eight suggestions...

  3. Global warming potential impact of bioenergy systems

    DEFF Research Database (Denmark)

    Tonini, Davide; Hamelin, L.; Wenzel, H.

    environmental consequences related to land use changes. In this study the global warming potential impact associated with six alternative bioenergy systems based on willow and Miscanthus was assessed by means of life-cycle assessment. The results showed that bioenergy production may generate higher global...... warming impacts than the reference fossil fuel system, when the impacts from indirect land use changes are accounted for. In a life-cycle perspective, only highly-efficient co-firing with fossil fuel achieved a (modest) GHG emission reduction....

  4. Global Warming - Are We on Thin Ice?

    Science.gov (United States)

    Tucker, Compton J.

    2007-01-01

    The evidence for global warming is very conclusive for the past 400-500 years. Prior to the 16th century, proxy surface temperature data are regionally good but lack a global distribution. The speaker will review surface temperature reconstruction based upon ice cores, coral cores, tree rings, deep sea sediments, and bore holes and discuss the controversy surrounding global warming. This will be contrasted with the excellent data we have from the satellite era of earth observations the past 30+ years that enables the quantitative study of climate across earth science disciplines.

  5. Winter warming from large volcanic eruptions

    Science.gov (United States)

    Robock, Alan; Mao, Jianping

    1992-01-01

    An examination of the Northern Hemisphere winter surface temperature patterns after the 12 largest volcanic eruptions from 1883-1992 shows warming over Eurasia and North America and cooling over the Middle East which are significant at the 95-percent level. This pattern is found in the first winter after tropical eruptions, in the first or second winter after midlatitude eruptions, and in the second winter after high latitude eruptions. The effects are independent of the hemisphere of the volcanoes. An enhanced zonal wind driven by heating of the tropical stratosphere by the volcanic aerosols is responsible for the regions of warming, while the cooling is caused by blocking of incoming sunlight.

  6. A real-time Global Warming Index.

    Science.gov (United States)

    Haustein, K; Allen, M R; Forster, P M; Otto, F E L; Mitchell, D M; Matthews, H D; Frame, D J

    2017-11-13

    We propose a simple real-time index of global human-induced warming and assess its robustness to uncertainties in climate forcing and short-term climate fluctuations. This index provides improved scientific context for temperature stabilisation targets and has the potential to decrease the volatility of climate policy. We quantify uncertainties arising from temperature observations, climate radiative forcings, internal variability and the model response. Our index and the associated rate of human-induced warming is compatible with a range of other more sophisticated methods to estimate the human contribution to observed global temperature change.

  7. Use of emulsion for warm mix asphalt

    Directory of Open Access Journals (Sweden)

    Mahabir Panda

    2017-06-01

    Full Text Available Due to increase in energy costs and emission problems in hot mix asphalt usually used, it brought a great interest to the researchers to develop the warm mix technology for pavement constructions. Commonly known as warm mix asphalt (WMA, it is a typical method in the bituminous paving technology, which allows production and placement of bituminous mixes at lower temperatures than that used for hot mix asphalt (HMA. The WMA involves an environmental friendly production process that utilises organic additives, chemical additives and water based technologies. The organic and chemical additives are normally very costly and still involve certain amount of environmental issues. These factors motivated the authors to take up this technology using simple, environment friendly and somewhat cost effective procedure. In this study, an attempt has been made to prepare warm mixes by first pre-coating the aggregates with medium setting bitumen emulsion (MS and then mixing the semi-coated aggregates with VG 30 bitumen at a lower temperature than normally required. After a number of trials it was observed that mostly three mixing temperatures, namely temperatures 110 °C, 120 °C and 130 °C were appropriate to form the bituminous mixes with satisfactory homogeneity and consistency and as such were maintained throughout this study. Marshall samples for paving mixes were prepared using this procedure for dense bituminous macadam (DBM gradings as per the specifications of Ministry of Road Transport and Highways (MORTH and subsequently Marshall properties of the resultant mixes were studied with the main objective of deciding the different parameters that were considered for development of appropriate warm mix asphalt. In this study it has been observed that out of three mixing temperatures tried, the mixes prepared at 120 °C with bitumen-emulsion composition of 80B:20E for DBM warm mix, offer highest Marshall stability and highest indirect tensile strength

  8. Humid Heat Waves at different warming levels

    Science.gov (United States)

    Russo, S.; Sillmann, J.; Sterl, A.

    2017-12-01

    The co-occurrence of consecutive hot and humid days during a heat wave can strongly affect human health. Here, we quantify humid heat wave hazard in the recent past and at different levels of global warming.We find that the magnitude and apparent temperature peak of heat waves, such as the ones observed in Chicago in 1995 and China in 2003, have been strongly amplified by humidity. Climate model projections suggest that the percentage of area where heat wave magnitude and peak are amplified by humidity increases with increasing warming levels. Considering the effect of humidity at 1.5o and 2o global warming, highly populated regions, such as the Eastern US and China, could experience heat waves with magnitude greater than the one in Russia in 2010 (the most severe of the present era).The apparent temperature peak during such humid-heat waves can be greater than 55o. According to the US Weather Service, at this temperature humans are very likely to suffer from heat strokes. Humid-heat waves with these conditions were never exceeded in the present climate, but are expected to occur every other year at 4o global warming. This calls for respective adaptation measures in some key regions of the world along with international climate change mitigation efforts.

  9. Abrupt warming of the Red Sea

    KAUST Repository

    Raitsos, D. E.

    2011-07-19

    Coral reef ecosystems, often referred to as “marine rainforests,” concentrate the most diverse life in the oceans. Red Sea reef dwellers are adapted in a very warm environment, fact that makes them vulnerable to further and rapid warming. The detection and understanding of abrupt temperature changes is an important task, as ecosystems have more chances to adapt in a slowly rather than in a rapid changing environment. Using satellite derived sea surface and ground based air temperatures, it is shown that the Red Sea is going through an intense warming initiated in the mid-90s, with evidence for an abrupt increase after 1994 (0.7°C difference pre and post the shift). The air temperature is found to be a key parameter that influences the Red Sea marine temperature. The comparisons with Northern Hemisphere temperatures revealed that the observed warming is part of global climate change trends. The hitherto results also raise additional questions regarding other broader climatic impacts over the area.

  10. CERN plans global-warming experiment

    CERN Multimedia

    De Laine, M

    1998-01-01

    A controversial theory that proposes that cosmic rays are responsible for global warming, is going to be tested at CERN. Experimentalists will use a cloud chamber to mimic the Earth's atmosphere in order to try and find out if cloud formation is influenced by solar activity (1 page).

  11. The global warming hiatus: Slowdown or redistribution?

    Science.gov (United States)

    Yan, Xiao-Hai; Boyer, Tim; Trenberth, Kevin; Karl, Thomas R.; Xie, Shang-Ping; Nieves, Veronica; Tung, Ka-Kit; Roemmich, Dean

    2016-11-01

    Global mean surface temperatures (GMST) exhibited a smaller rate of warming during 1998-2013, compared to the warming in the latter half of the 20th Century. Although, not a "true" hiatus in the strict definition of the word, this has been termed the "global warming hiatus" by IPCC (2013). There have been other periods that have also been defined as the "hiatus" depending on the analysis. There are a number of uncertainties and knowledge gaps regarding the "hiatus." This report reviews these issues and also posits insights from a collective set of diverse information that helps us understand what we do and do not know. One salient insight is that the GMST phenomenon is a surface characteristic that does not represent a slowdown in warming of the climate system but rather is an energy redistribution within the oceans. Improved understanding of the ocean distribution and redistribution of heat will help better monitor Earth's energy budget and its consequences. A review of recent scientific publications on the "hiatus" shows the difficulty and complexities in pinpointing the oceanic sink of the "missing heat" from the atmosphere and the upper layer of the oceans, which defines the "hiatus." Advances in "hiatus" research and outlooks (recommendations) are given in this report.

  12. Qualitative models of global warming amplifiers

    NARCIS (Netherlands)

    Milošević, U.; Bredeweg, B.; de Kleer, J.; Forbus, K.D.

    2010-01-01

    There is growing interest from ecological experts to create qualitative models of phenomena for which numerical information is sparse or missing. We present a number of successful models in the field of environmental science, namely, the domain of global warming. The motivation behind the effort is

  13. NASA: Black soot fuels global warming

    CERN Multimedia

    2003-01-01

    New research from NASA's Goddard Space Center scientists suggests emissions of black soot have been altering the way sunlight reflects off Earth's snow. The research indicates the soot could be responsible for as much as 25 percent of global warming over the past century (assorted news items, 1 paragraph each).

  14. Wind changes above warm Agulhas Current eddies

    CSIR Research Space (South Africa)

    Roualt, M

    2016-10-01

    Full Text Available Sea-surface temperature (SST), altimetry derived sea-level anomalies (SLA) and surface current are used south of the Agulhas Current to identify warm core mesoscale ocean eddies presenting a distinct SST perturbation superior to 1(supo...

  15. Wind changes above warm Agulhas Current eddies

    CSIR Research Space (South Africa)

    Rouault, M

    2016-01-01

    Full Text Available speeds above the eddies at the instantaneous scale; 20 % of cases had incomplete data due to partial global coverage by the scatterometer for one path. For cases where the wind is stronger above warm eddies, there is no relationship between the increase...

  16. Can warming particles enter global climate discussions?

    International Nuclear Information System (INIS)

    Bond, Tami C

    2007-01-01

    'Soot' or 'black carbon', which comes from incomplete combustion, absorbs light and warms the atmosphere. Although there have been repeated suggestions that reduction of black carbon could be a viable part of decreasing global warming, it has not yet been considered when choosing actions to reduce climatic impact. In this paper, I examine four conceptual barriers to the consideration of aerosols in global agreements. I conclude that some of the major objections to considering aerosols under hemispheric or global agreements are illusory because: (1) a few major sources will be addressed by local regulations, but the remainder may not be addressed by traditional air quality management; (2) climate forcing by carbon particles is not limited to 'hot spots'-about 90% of it occurs at relatively low concentrations; (3) while aerosol science is complex, the most salient characteristics of aerosol behavior can be condensed into tractable metrics including, but not limited to, the global warming potential; (4) despite scientific uncertainties, reducing all aerosols from major sources of black carbon will reduce direct climate warming with a very high probability. This change in climate forcing accounts for at least 25% of the accompanying CO 2 forcing with significant probability (25% for modern diesel engines, 90% for superemitting diesels, and 55% for cooking with biofuels). Thus, this fraction of radiative forcing should not be ignored

  17. Greenhouse warming and changes in sea level

    NARCIS (Netherlands)

    Oerlemans, J.

    1989-01-01

    It is likely that the anticipated warming due to the effect of increasing concentration of carbon dioxide and other greenhouse gases will lead to a further and faster rise in world mean sea level. There are many processes in the climate system controlling sea level, but the most important

  18. Dynamical Analysis of the Global Warming

    Directory of Open Access Journals (Sweden)

    J. A. Tenreiro Machado

    2012-01-01

    Full Text Available Global warming is a major concern nowadays. Weather conditions are changing, and it seems that human activity is one of the main causes. In fact, since the beginning of the industrial revolution, the burning of fossil fuels has increased the nonnatural emissions of carbon dioxide to the atmosphere. Carbon dioxide is a greenhouse gas that absorbs the infrared radiation produced by the reflection of the sunlight on the Earth’s surface, trapping the heat in the atmosphere. Global warming and the associated climate changes are being the subject of intensive research due to their major impact on social, economic, and health aspects of human life. This paper studies the global warming trend in the perspective of dynamical systems and fractional calculus, which is a new standpoint in this context. Worldwide distributed meteorological stations and temperature records for the last 100 years are analysed. It is shown that the application of Fourier transforms and power law trend lines leads to an assertive representation of the global warming dynamics and a simpler analysis of its characteristics.

  19. Laboratory evaluation of warm mix asphalt.

    Science.gov (United States)

    2011-09-14

    "Hot Mix Asphalt (HMA) has been traditionally produced at a discharge temperature of between : 280F (138C) and 320 F (160C), resulting in high energy (fuel) costs and generation of greenhouse : gases. The goal for Warm Mix Asphalt (WMA) is to...

  20. Warm damper for a superconducting rotor

    International Nuclear Information System (INIS)

    Hooper, G.D.

    1984-01-01

    A warm damper for a superconducting rotor is described which uses a laminar assembly of a conductive tube and a plurality of support tubes. The conductive tube is soldered to axially adjacent support tubes and the resulting composite tube is explosively welded to two or more support tubes disposed adjacent to its radially inner and outer surfaces

  1. Abrupt warming of the Red Sea

    Science.gov (United States)

    Raitsos, D. E.; Hoteit, I.; Prihartato, P. K.; Chronis, T.; Triantafyllou, G.; Abualnaja, Y.

    2011-07-01

    Coral reef ecosystems, often referred to as “marine rainforests,” concentrate the most diverse life in the oceans. Red Sea reef dwellers are adapted in a very warm environment, fact that makes them vulnerable to further and rapid warming. The detection and understanding of abrupt temperature changes is an important task, as ecosystems have more chances to adapt in a slowly rather than in a rapid changing environment. Using satellite derived sea surface and ground based air temperatures, it is shown that the Red Sea is going through an intense warming initiated in the mid-90s, with evidence for an abrupt increase after 1994 (0.7°C difference pre and post the shift). The air temperature is found to be a key parameter that influences the Red Sea marine temperature. The comparisons with Northern Hemisphere temperatures revealed that the observed warming is part of global climate change trends. The hitherto results also raise additional questions regarding other broader climatic impacts over the area.

  2. Can Global Warming Heat Up Environmental Education?

    Science.gov (United States)

    Mazzatenta, Claudio

    2008-01-01

    Bronx Community College (CUNY) launched "Global Warming Campus Awareness and Action Days" in celebration of Earth Day, 2007. The purpose of this program was to raise awareness of environmental issues in the college population, especially students. To let more students have a grasp of what Environmental Education (EE) is all about, the author…

  3. Global warming -- Science and anti-science

    Energy Technology Data Exchange (ETDEWEB)

    Preining, O. [Univ. of Vienna, Wien (Austria). Inst. for Experimental Physics]|[Austrian Academy of Sciences, Wien (Austria). Clean Air Commission

    1995-06-01

    The global warming debate has sparked many facts activities in almost all sectors of human endeavors. There are the hard facts, the measurements of the greenhouse gases, the statistics of human activities responsible for emissions, the demographic figures. There are the soft facts, the interpretations of the hard facts requiring additional assumptions. There are the media, the press, television, for whom environmental problems make good stories, these can be used to rise emotions, to make heroes and antiheroes. There are politicians, the global warming debate can be used even in electron campaigns. Global warming is a topic within and beyond science. The judgment (and hence use) of scientific facts is overwhelmingly influenced by the ``Weltbild`` (underlying beliefs how the world operates), and consequently opposing positions of well-known scientists arise. There are the attempts to invent futures of man on Earth: policies, regulations, laws on nation, international, and global levels shall facilitate a change in the basic behavior of all men. The global warming issue has many facets and cannot be successfully discussed without including, e.g., the North-South dialogue, world population, etc.

  4. Warm Hydroforming of Lightweight Metal Sheets

    International Nuclear Information System (INIS)

    Aginagalde, A.; Orus, A.; Esnaola, J. A.; Torca, I.; Galdos, L.; Garcia, C.

    2007-01-01

    Hydroforming is well known in steel applications for automotive industry, where complicated shapes can be get with high strength to weight ratios. Nevertheless, the poor formability of light alloys at room temperature has limited the application of hydroforming technology for aluminum and magnesium parts. Increasing the temperature of these materials allows substantially greater elongation without fracture. Warm forming strategy is applied in conventional processes, such as rolling and forging, in order to get complex shapes, but still rare in hydroforming technology. This is the technical base of this research project: the development of the hydroforming process at warm working temperatures. The main tasks of the initial phases of the research were the material characterization, and the heated fluid and tooling system design and set up for warm hydroforming of lightweight alloys. Once these goals were accomplished the present paper shows the obtained results. The uniaxial tensile deformation of 5754H111, 6082-T6, 6082-O and AZ31B at the temperature range of 25 deg. C - 250 deg. C is presented as the output of the material characterization task. Both the system features and the results obtained for a bulge test geometry carried out with a warm hydroforming system are also presented. The selected alloys show an improvement in formability at the studied temperature range under both uniaxial and biaxial state of stress

  5. National contributions to observed global warming

    International Nuclear Information System (INIS)

    Matthews, H Damon; Graham, Tanya L; Keverian, Serge; Lamontagne, Cassandra; Seto, Donny; Smith, Trevor J

    2014-01-01

    There is considerable interest in identifying national contributions to global warming as a way of allocating historical responsibility for observed climate change. This task is made difficult by uncertainty associated with national estimates of historical emissions, as well as by difficulty in estimating the climate response to emissions of gases with widely varying atmospheric lifetimes. Here, we present a new estimate of national contributions to observed climate warming, including CO 2 emissions from fossil fuels and land-use change, as well as methane, nitrous oxide and sulfate aerosol emissions While some countries’ warming contributions are reasonably well defined by fossil fuel CO 2 emissions, many countries have dominant contributions from land-use CO 2 and non-CO 2 greenhouse gas emissions, emphasizing the importance of both deforestation and agriculture as components of a country’s contribution to climate warming. Furthermore, because of their short atmospheric lifetime, recent sulfate aerosol emissions have a large impact on a country’s current climate contribution We show also that there are vast disparities in both total and per-capita climate contributions among countries, and that across most developed countries, per-capita contributions are not currently consistent with attempts to restrict global temperature change to less than 2 °C above pre-industrial temperatures. (paper)

  6. Impact of warm winters on microbial growth

    Science.gov (United States)

    Birgander, Johanna; Rousk, Johannes; Axel Olsson, Pål

    2014-05-01

    Growth of soil bacteria has an asymmetrical response to higher temperature with a gradual increase with increasing temperatures until an optimum after which a steep decline occurs. In laboratory studies it has been shown that by exposing a soil bacterial community to a temperature above the community's optimum temperature for two months, the bacterial community grows warm-adapted, and the optimum temperature of bacterial growth shifts towards higher temperatures. This result suggests a change in the intrinsic temperature dependence of bacterial growth, as temperature influenced the bacterial growth even though all other factors were kept constant. An intrinsic temperature dependence could be explained by either a change in the bacterial community composition, exchanging less tolerant bacteria towards more tolerant ones, or it could be due to adaptation within the bacteria present. No matter what the shift in temperature tolerance is due to, the shift could have ecosystem scale implications, as winters in northern Europe are getting warmer. To address the question of how microbes and plants are affected by warmer winters, a winter-warming experiment was established in a South Swedish grassland. Results suggest a positive response in microbial growth rate in plots where winter soil temperatures were around 6 °C above ambient. Both bacterial and fungal growth (leucine incorporation, and acetate into ergosterol incorporation, respectively) appeared stimulated, and there are two candidate explanations for these results. Either (i) warming directly influence microbial communities by modulating their temperature adaptation, or (ii) warming indirectly affected the microbial communities via temperature induced changes in bacterial growth conditions. The first explanation is in accordance with what has been shown in laboratory conditions (explained above), where the differences in the intrinsic temperature relationships were examined. To test this explanation the

  7. Frequency of Deep Convective Clouds and Global Warming

    Science.gov (United States)

    Aumann, Hartmut H.; Teixeira, Joao

    2008-01-01

    This slide presentation reviews the effect of global warming on the formation of Deep Convective Clouds (DCC). It concludes that nature responds to global warming with an increase in strong convective activity. The frequency of DCC increases with global warming at the rate of 6%/decade. The increased frequency of DCC with global warming alone increases precipitation by 1.7%/decade. It compares the state of the art climate models' response to global warming, and concludes that the parametrization of climate models need to be tuned to more closely emulate the way nature responds to global warming.

  8. ORBITAL INJURIES

    Directory of Open Access Journals (Sweden)

    Andrej Kansky

    2002-12-01

    Full Text Available Background. Orbit is involved in 40% of all facial fractures. There is considerable variety in severity, ranging from simple nondisplaced to complex comminuted fractures. Complex comminuted fractures (up to 20% are responsible for the majority of complications and unfavorable results. Orbital fractures are classified as internal orbital fractures, zygomatico-orbital fractures, naso-orbito-ethmoidal fractures and combined fractures. The ophtalmic sequelae of midfacial fractures are usually edema and ecchymosis of the soft tissues, subconjuctival hemorrhage, diplopia, iritis, retinal edema, ptosis, enophthalmos, ocular muscle paresis, mechanical restriction of ocular movement and nasolacrimal disturbances. More severe injuries such as optic nerve trauma and retinal detachments have also been reported. Within the wide range of orbital fractures small group of complex fractures causes most of the sequelae. Therefore identification of severe injuries and adequate treatment is of major importance. The introduction of craniofacial techniques made possible a wide exposure even of large orbital wall defects and their reconstruction by bone grafts. In spite of significant progress, repair of complex orbital wall defects remains a problem even for the experienced surgeons.Results. In 1999 121 facial injuries were treated at our department (Clinical Centre Ljubljana Dept. Of Maxillofacial and Oral Surgery. Orbit was involved in 65% of cases. Isolated inner orbital fractures presented 4% of all fractures. 17 (14% complex cases were treated, 5 of them being NOE, 5 orbital (frame and inner walls, 3 zygomatico-orbital, 2 FNO and 2 maxillo-orbital fractures.Conclusions. Final result of the surgical treatment depends on severity of maxillofacial trauma. Complex comminuted fractures are responsable for most of the unfavorable results and ocular function is often permanently damaged (up to 75% in these fractures.

  9. Time-dependent postural control adaptations following a neuromuscular warm-up in female handball players: a randomized controlled trial.

    Science.gov (United States)

    Steib, Simon; Zahn, Peter; Zu Eulenburg, Christine; Pfeifer, Klaus; Zech, Astrid

    2016-01-01

    Female handball athletes are at a particular risk of sustaining lower extremity injuries. The study examines time-dependent adaptations of static and dynamic balance as potential injury risk factors to a specific warm-up program focusing on neuromuscular control. Fourty one (24.0 ± 5.9 years) female handball athletes were randomized to an intervention or control group. The intervention group implemented a 15-min specific neuromuscular warm-up program, three times per week for eleven weeks, whereas the control group continued with their regular warm-up. Balance was assessed at five time points. Measures included the star excursion balance test (SEBT), and center of pressure (COP) sway velocity during single-leg standing. No baseline differences existed between groups in demographic data. Adherence to neuromuscular warm-up was 88.7 %. Mean COP sway velocity decreased significantly over time in the intervention group (-14.4 %; p  control group (-6.2 %; p  = 0.056). However, these effects did not differ significantly between groups ( p  = .098). Mean changes over time in the SEBT score were significantly greater ( p  = .014) in the intervention group (+5.48) compared to the control group (+3.45). Paired t-tests revealed that the first significant balance improvements were observed after 6 weeks of training. A neuromuscular warm-up positively influences balance variables associated with an increased risk of lower extremity injuries in female handball athletes. The course of adaptations suggests that a training volume of 15 min, three times weekly over at least six weeks produces measurable changes. Retrospectively registered on 4th October 2016. Registry: clinicaltrials.gov. Trial number: NCT02925377.

  10. Warmed local anesthetic reduces pain of infiltration.

    Science.gov (United States)

    Fialkov, J A; McDougall, E P

    1996-01-01

    The effect of warming local anesthetic on the amount of pain experienced during local infiltration was tested by comparing equal volumes of 40 degrees C- and 21 degrees C-infiltrates in each of 26 subjects. Six subjects were patients undergoing excision of two benign asymptomatic nevi in separate locations, and 20 subjects were healthy adult volunteers who were injected in bilateral antebrachial sites. The warmed and room temperature solutions were randomized to each side, so that each subject received both temperature injections in random order. All subjects and the injector were blinded. The rate of injection was time-controlled (0.05 ml/sec). Following both injections, subjects were asked to rate the pain experienced at each site. In addition, the subject was asked if there was no difference, a slight difference, or a substantial difference between the two sites. A two-tailed paired t-test was used to analyze the mean difference in pain scores for all subjects. Paired analysis of the pain scores for each subject eliminated intersubject variance of pain tolerance. The mean difference in pain score between the room temperature and warmed solutions was +1.5 (p < 0.0001). Of the 21 subjects (81%) who found the warmed solution less painful, 11 (52%) found the difference to be significant, while 10 (48%) found the difference to be slight. Two subjects (8%) found no difference between the two, while 3 subjects (11%) found the colder solution slightly less painful. We conclude that warming local anesthetic to 40 degrees C prior to subcutaneous injection is a simple, inexpensive means of reducing the pain of local infiltration.

  11. Experimental winter warming modifies thermal performance and primes acorn ants for warm weather

    DEFF Research Database (Denmark)

    MacLean, Heidi J.; Penick, Clint A.; Dunn, Robert R.

    2017-01-01

    The frequency of warm winter days is increasing under global climate change, but how organisms respond to warmer winters is not well understood. Most studies focus on growing season responses to warming. Locomotor performance is often highly sensitive to temperature, and can determine fitness...... outcomes through a variety of mechanisms including resource acquisition and predator escape. As a consequence, locomotor performance, and its impacts on fitness, may be strongly affected by winter warming in winter-active species. Here we use the acorn ant, Temnothorax curvispinosus, to explore how thermal...... performance (temperature-driven plasticity) in running speed is influenced by experimental winter warming of 3–5 °C above ambient in a field setting. We used running speed as a measure of performance as it is a common locomotor trait that influences acquisition of nest sites and food in acorn ants...

  12. Increasing occurrence of cold and warm extremes during the recent global warming slowdown.

    Science.gov (United States)

    Johnson, Nathaniel C; Xie, Shang-Ping; Kosaka, Yu; Li, Xichen

    2018-04-30

    The recent levelling of global mean temperatures after the late 1990s, the so-called global warming hiatus or slowdown, ignited a surge of scientific interest into natural global mean surface temperature variability, observed temperature biases, and climate communication, but many questions remain about how these findings relate to variations in more societally relevant temperature extremes. Here we show that both summertime warm and wintertime cold extreme occurrences increased over land during the so-called hiatus period, and that these increases occurred for distinct reasons. The increase in cold extremes is associated with an atmospheric circulation pattern resembling the warm Arctic-cold continents pattern, whereas the increase in warm extremes is tied to a pattern of sea surface temperatures resembling the Atlantic Multidecadal Oscillation. These findings indicate that large-scale factors responsible for the most societally relevant temperature variations over continents are distinct from those of global mean surface temperature.

  13. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... About Media Donate Spinal Cord Injury Medical Expert Videos ... Home Kim Eberhardt Muir, MS Coping with a New Injury Robin Dorman, PsyD Sex and Fertility After Spinal Cord Injury Diane M. ...

  14. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... spinal cord injury? play_arrow What kind of surgery is common after a spinal cord injury? play_ ... How soon after a spinal cord injury should surgery be performed? play_arrow Is it common to ...

  15. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... L Sarah Harrison, OT Anne Bryden, OT The Role of the Social Worker after Spinal Cord Injury ... a spinal cord injury important? play_arrow What role does “compression” play in a spinal cord injury? ...

  16. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Injury Facts and Figures Care and Treatment After SCI Spinal Cord Injury Rehabilitation Pediatric Spinal Cord Injuries Video Library SCI Medical Experts People Living with SCI Personal Experiences ...

  17. Radiotherapy injuries in children

    International Nuclear Information System (INIS)

    Kalifa, G.; Bennet, J.; Couanet, D.; Masselot, J.

    1985-01-01

    Side effects of radiotherapy in pediatrics are reviewed including bone injuries and radio-induced bone tumors; nervous system injuries with emphasis on hypothalamus, pituitary gland, brain and spinal cord; lung, digestive system and urinary tract injuries [fr

  18. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Counseling Blog About Media Donate Spinal Cord Injury Medical Expert Videos Topics menu Topics Spinal Cord Injury ... Jennifer Piatt, PhD David Chen, MD Read Bio Medical Director, Spinal Cord Injury Rehabilitation Program, Rehabilitation Institute ...

  19. Facial Sports Injuries

    Science.gov (United States)

    ... Marketplace Find an ENT Doctor Near You Facial Sports Injuries Facial Sports Injuries Patient Health Information News ... should receive immediate medical attention. Prevention Of Facial Sports Injuries The best way to treat facial sports ...

  20. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Blog About Media Donate Spinal Cord Injury Medical Expert Videos Topics menu Topics Spinal Cord Injury 101 ... arrow What is the “Spinal Cord Injury Model Systems” program? play_arrow What are the most promising ...

  1. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... RN Pediatric Injuries Pediatric Spinal Cord Injury 101 Lawrence Vogel, MD The Basics of Pediatric SCI Rehabilitation ... Rogers, PT Recreational Therapy after Spinal Cord Injury Jennifer Piatt, PhD David Chen, MD Read Bio Medical ...

  2. Preventing Knee Injuries

    Science.gov (United States)

    ... Our Newsletter Donate Blog Skip breadcrumb navigation Preventing Knee Injuries Knee injuries in children and adolescent athletes ... this PDF Share this page: WHAT ARE COMMON KNEE INJURIES? Pain Syndromes One of the most common ...

  3. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Spinal Cord Injury 101 Lawrence Vogel, MD The Basics of Pediatric SCI Rehabilitation Sara Klaas, MSW Transitions for Children with Spinal Cord Injury Patricia Mucia, RN Family Life After Pediatric Spinal Injury Dawn Sheaffer, MSW Rehabilitation ...

  4. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Spinal Cord Injury 101 David Chen, MD Preventing Pressure Sores Mary Zeigler, MS Transition from Hospital to ... a spinal cord injury? play_arrow Why are high-dose steroids often used right after an injury? ...

  5. Warming up and cooling down (image)

    Science.gov (United States)

    ... for 5 to 10 minutes, one may avoid injury and build endurance over time. Cooling down after exercise by walking slowly, then stretching muscles, may also prevent strains and blood pressure fluctuation.

  6. Intensified Arctic warming under greenhouse warming by vegetation–atmosphere–sea ice interaction

    International Nuclear Information System (INIS)

    Jeong, Jee-Hoon; Kug, Jong-Seong; Linderholm, Hans W; Chen, Deliang; Kim, Baek-Min; Jun, Sang-Yoon

    2014-01-01

    Observations and modeling studies indicate that enhanced vegetation activities over high latitudes under an elevated CO 2 concentration accelerate surface warming by reducing the surface albedo. In this study, we suggest that vegetation-atmosphere-sea ice interactions over high latitudes can induce an additional amplification of Arctic warming. Our hypothesis is tested by a series of coupled vegetation-climate model simulations under 2xCO 2 environments. The increased vegetation activities over high latitudes under a 2xCO 2 condition induce additional surface warming and turbulent heat fluxes to the atmosphere, which are transported to the Arctic through the atmosphere. This causes additional sea-ice melting and upper-ocean warming during the warm season. As a consequence, the Arctic and high-latitude warming is greatly amplified in the following winter and spring, which further promotes vegetation activities the following year. We conclude that the vegetation-atmosphere-sea ice interaction gives rise to additional positive feedback of the Arctic amplification. (letter)

  7. Irrigation enhances local warming with greater nocturnal warming effects than daytime cooling effects

    Science.gov (United States)

    Chen, Xing; Jeong, Su-Jong

    2018-02-01

    To meet the growing demand for food, land is being managed to be more productive using agricultural intensification practices, such as the use of irrigation. Understanding the specific environmental impacts of irrigation is a critical part of using it as a sustainable way to provide food security. However, our knowledge of irrigation effects on climate is still limited to daytime effects. This is a critical issue to define the effects of irrigation on warming related to greenhouse gases (GHGs). This study shows that irrigation led to an increasing temperature (0.002 °C year-1) by enhancing nighttime warming (0.009 °C year-1) more than daytime cooling (-0.007 °C year-1) during the dry season from 1961-2004 over the North China Plain (NCP), which is one of largest irrigated areas in the world. By implementing irrigation processes in regional climate model simulations, the consistent warming effect of irrigation on nighttime temperatures over the NCP was shown to match observations. The intensive nocturnal warming is attributed to energy storage in the wetter soil during the daytime, which contributed to the nighttime surface warming. Our results suggest that irrigation could locally amplify the warming related to GHGs, and this effect should be taken into account in future climate change projections.

  8. [Effects of the of renal warm ischemia time on the recovery of filtration function in the experiment].

    Science.gov (United States)

    Guseinov, R G; Popov, S V; Gorshkov, A N; Sivak, K V; Martov, A G

    2017-12-01

    To investigate experimentally ultrastructural and biochemical signs of acute injury to the renal parenchyma after warm renal ischemia of various duration and subsequent reperfusion. The experiments were performed on 44 healthy conventional female rabbits of the "Chinchilla" breed weighted 2.6-2.7 kg, which were divided into four groups. In the first, control, group included pseudo-operated animals. In the remaining three groups, an experimental model of warm ischemia of renal tissue was created, followed by a 60-minute reperfusion. The renal warm ischemia time was 30, 60 and 90 minutes in the 2nd, 3rd and 4th groups, respectively. Electron microscopy was used to study ultrastructural disturbances of the renal parenchyma. Biochemical signs of acute kidney damage were detected by measuring the following blood serum and/or urine analytes: NGAL, cystatin C, KIM-1, L-FABP, interleukin-18. The glomerular filtration was evaluated by creatinine clearance, which was determined on days 1, 5, 7, 14, 21 and 35 of follow-up. A 30-minute renal warm ischemia followed by a 60-minute reperfusion induced swelling and edema of the brush membrane, vacuolation of the cytoplasm of the endothelial cells of the proximal tubules, and microvilli restructuring. The observed disorders were reversible, and the epithelial cells retained their viability. After 60 minutes of ischemia and 60 minutes of reperfusion, the observed changes in the ultrastructure of the epithelial cells were much more pronounced, some of the epithelial cells were in a state of apoptosis. 90 min of ischemia and 60 min of reperfusion resulted in electron-microscopic signs of the mass cellular death of the tubular epithelium. Concentration in serum and/or biochemical urine markers of acute renal damage increased sharply after ischemic-reperfusion injury. Restoration of indicators was observed only in cases when the renal warm ischemia time did not exceed 60 minutes. The decrease in creatinine clearance occurred in the

  9. Alabama warm mix asphalt field study : final report.

    Science.gov (United States)

    2010-05-01

    The Alabama Department of Transportation hosted a warm mix asphalt field demonstration in August 2007. The warm mix asphalt technology demonstrated was Evotherm Dispersed Asphalt Technology. The WMA and hot mix asphalt produced for the demonstration ...

  10. Eutrophication and warming boost cyanobacterial biomass and microcystins

    NARCIS (Netherlands)

    Lurling, Miguel; Oosterhout, Jean; Faassen, Els

    2017-01-01

    Eutrophication and warming are key drivers of cyanobacterial blooms, but their combined effects on microcystin (MC) concentrations are less studied. We tested the hypothesis that warming promotes cyanobacterial abundance in a natural plankton community and that eutrophication enhances cyanobacterial

  11. Mild Traumatic Brain Injury

    Science.gov (United States)

    ... mild Traumatic Brain Injury Resilience Families with Kids Depression Families & Friendships Tobacco Life Stress Spirituality Anger Physical Injury Stigma Health & Wellness Work Adjustment Community Peer-2-Peer Forum ...

  12. Baseball and softball injuries.

    Science.gov (United States)

    Wang, Quincy

    2006-05-01

    Baseball and softball injuries can be a result of both acute and overuse injuries. Soft tissue injuries include contusions, abrasions, and lacerations. Return to play is allowed when risk of further injury is minimized. Common shoulder injuries include those to the rotator cuff, biceps tendon, and glenoid labrum. Elbow injuries are common in baseball and softball and include medial epicondylitis, ulnar collateral ligament injury, and osteochondritis dissecans. Typically conservative treatment with relative rest, medication, and a rehabilitation program will allow return to play. Surgical intervention may be needed for certain injuries or conservative treatment failure.

  13. Implications of global warming on human health

    International Nuclear Information System (INIS)

    Singh, R.K.; Syam, P.V.S.

    1997-01-01

    Due to the build up of green house gases in atmosphere, less heat escapes through the atmosphere promoting global warming. This may result in world wide droughts, sea-level rise inundating islands and coastal countries, cataclysmic hurricanes etc. Human health as a result of these changes, will be affected both physiologically and psychologically. Physiological effects may be more pronounced in cases occurring due to changes in rainfall and temperature patterns, food production amounts, water availability, etc. Psychological impact may be more in cases of catastrophes like floods, hurricanes or famine. In this paper, an attempt has been made to highlight the implications of global warming on human health due to temperature change. Food production changes and ultra-violet radiation effects and cataclysmic disaster effects. (author)

  14. Magnetic fusion development for global warming suppression

    International Nuclear Information System (INIS)

    Li Jiangang; Zhang Jie; Duan Xuru

    2010-01-01

    Energy shortage and environmental pollution are two critical issues for human beings in the 21st century. There is an urgent need for new sustainable energy to meet the fast growing demand for clean energy. Fusion is one of the few options which may be able to satisfy the requirement for large scale sustainable energy generation and global warming suppression and therefore must be developed as quickly as possible. Fusion research has been carried out for the past 50 years. It is too long to wait for another 50 years to generate electricity by fusion. A much more aggressive approach should be taken with international collaboration towards the early use of fusion energy to meet the urgent needs for energy and global warming suppression.

  15. Viscous warm inflation: Hamilton-Jacobi formalism

    Science.gov (United States)

    Akhtari, L.; Mohammadi, A.; Sayar, K.; Saaidi, Kh.

    2017-04-01

    Using Hamilton-Jacobi formalism, the scenario of warm inflation with viscous pressure is considered. The formalism gives a way of computing the slow-rolling parameter without extra approximation, and it is well-known as a powerful method in cold inflation. The model is studied in detail for three different cases of the dissipation and bulk viscous pressure coefficients. In the first case where both coefficients are taken as constant, it is shown that the case could not portray warm inflationary scenario compatible with observational data even it is possible to restrict the model parameters. For other cases, the results shows that the model could properly predicts the perturbation parameters in which they stay in perfect agreement with Planck data. As a further argument, r -ns and αs -ns are drown that show the acquired result could stand in acceptable area expressing a compatibility with observational data.

  16. Is man responsible for global warming?

    International Nuclear Information System (INIS)

    Legendre, A.

    2009-01-01

    According to politicians, ecologists and mass media, it is now certain that with our CO 2 emissions, we are all responsible for a major global warming to come with dramatic consequences. But, is this affirmation indisputable? Are we all responsible for the rise of sea level and the summer thawing of the arctic ice shelf? Is this expected global warming without precedent? And is CO 2 , necessary for life, the cause of our misfortune? The answers commonly claimed are maybe more complex in reality and the climate question more subtle than it looks like. This book tries to decode the wheels of the climate machine and the share of human responsibility in climate change. (J.S.)

  17. Indian Ocean warming modulates Pacific climate change

    Science.gov (United States)

    Luo, Jing-Jia; Sasaki, Wataru; Masumoto, Yukio

    2012-01-01

    It has been widely believed that the tropical Pacific trade winds weakened in the last century and would further decrease under a warmer climate in the 21st century. Recent high-quality observations, however, suggest that the tropical Pacific winds have actually strengthened in the past two decades. Precise causes of the recent Pacific climate shift are uncertain. Here we explore how the enhanced tropical Indian Ocean warming in recent decades favors stronger trade winds in the western Pacific via the atmosphere and hence is likely to have contributed to the La Niña-like state (with enhanced east–west Walker circulation) through the Pacific ocean–atmosphere interactions. Further analysis, based on 163 climate model simulations with centennial historical and projected external radiative forcing, suggests that the Indian Ocean warming relative to the Pacific’s could play an important role in modulating the Pacific climate changes in the 20th and 21st centuries. PMID:23112174

  18. Indian Ocean warming modulates Pacific climate change.

    Science.gov (United States)

    Luo, Jing-Jia; Sasaki, Wataru; Masumoto, Yukio

    2012-11-13

    It has been widely believed that the tropical Pacific trade winds weakened in the last century and would further decrease under a warmer climate in the 21st century. Recent high-quality observations, however, suggest that the tropical Pacific winds have actually strengthened in the past two decades. Precise causes of the recent Pacific climate shift are uncertain. Here we explore how the enhanced tropical Indian Ocean warming in recent decades favors stronger trade winds in the western Pacific via the atmosphere and hence is likely to have contributed to the La Niña-like state (with enhanced east-west Walker circulation) through the Pacific ocean-atmosphere interactions. Further analysis, based on 163 climate model simulations with centennial historical and projected external radiative forcing, suggests that the Indian Ocean warming relative to the Pacific's could play an important role in modulating the Pacific climate changes in the 20th and 21st centuries.

  19. Warm Debris Disk Candidates from WISE

    Science.gov (United States)

    Padgett, Deborah; Stapelfeldt, Karl; Liu, Wilson; Leisawitz, David

    2011-01-01

    The Wide Field Infrared Survey Explorer (WISE) has just completed a sensitive all-sky survey in photometric bands at 3.4, 4.6, 12, and 22 microns. We report on a preliminary investigation of main sequence Hipparcos and Tycho catalog stars with 22 micron emission in excess of photospheric levels. This warm excess emission traces material in the circumstellar region likely to host terrestrial planets and is preferentially found in young systems with ages warm debris disk candidates are detected among FGK stars and 150 A stars within 120 pc. We are in the process of obtaining spectra to determine spectral types and activity level of these stars and are using HST, Herschel and Keck to characterize the dust, multiplicity, and substellar companions of these systems. In this contribution, we will discuss source selection methods and individual examples from among the WISE debris disk candidates.

  20. Radiation injury

    International Nuclear Information System (INIS)

    Hubner, K.F.

    1988-01-01

    Radiation accidents and incidents continue to be of great interest and concern to the public. Issues such as the threat of nuclear war, the Chernobyl reactor accident, or reports of sporadic incidences of accidental radiation exposure keep this interest up and maintain a high level of fear among the public. In this climate of real concern and radiation phobia, physicians should not only be prepared to answer questions about acute or late effects of ionizing radiation, but also be able to participate in the initial assessment and management of individuals who have been exposed to ionizing radiation or contaminated with radioactive material. Some of the key facts about radiation injury and its medical treatment are discussed by the author

  1. Oxidative Stress after Surgery on the Immature Heart

    Directory of Open Access Journals (Sweden)

    Daniel Fudulu

    2016-01-01

    Full Text Available Paediatric heart surgery is associated with increased inflammation and the production of reactive oxygen species. Use of the extracorporeal cardiopulmonary bypass during correction of congenital heart defects generates reactive oxygen species by various mechanisms: haemolysis, neutrophil activation, ischaemia reperfusion injury, reoxygenation injury, or depletion of the endogenous antioxidants. The immature myocardium is more vulnerable to reactive oxygen species because of developmental differences compared to the adult heart but also because of associated congenital heart diseases that can deplete its antioxidant reserve. Oxidative stress can be manipulated by various interventions: exogenous antioxidants, use of steroids, cardioplegia, blood prime strategies, or miniaturisation of the cardiopulmonary bypass circuit. However, it is unclear if modulation of the redox pathways can alter clinical outcomes. Further studies powered to look at clinical outcomes are needed to define the role of oxidative stress in paediatric patients.

  2. Book ReviewL Global Warming

    OpenAIRE

    Nadia Astriani

    2015-01-01

    Global Warming is part of Greenhaven’s Contemporary Issues Companion series published by, Thomson Gale on 2005. Each volume of the anthologyseries focuses on a topic of current interest, presenting informative and thought-provoking selection written from wide-variety viewpoints. It is an ideal launching point for research on a particular topic. Each anthology in the series is composed of readings taken from an extensive gamut of resources, including periodical, newspapers, books, governmentdo...

  3. Global warming : a guide to the science

    International Nuclear Information System (INIS)

    Soon, W.; Baliunas, S.L.; Robinson, A.B.; Robinson, Z.W.

    2001-01-01

    This guide dispels the popular hypothesis that increases in carbon dioxide in the atmosphere resulting from increased industrial activity have caused global warming. The report suggests that there is no evidence of catastrophic anthropogenic global warming and that temperature changes over the last 100 years has been due mostly to natural phenomena. The global temperature has increased by about 0.5 to 0.6 degrees C in the past 100 years, and this, before most of the greenhouse gases were added to the air by human activities such as burning of fossil fuels. The initial major rise in temperature was in 1940, before the rise in carbon dioxide levels, therefore, it was suggested that this warming must have been natural in origin. Computer based simulations of the climate system forecast disastrous rises in global temperature. But it was argued that current climate models are not accurate in forecasting future climate change because it is not possible to isolate the effect of an increased concentration of atmospheric carbon dioxide on climate because about 5 million different variables have to be considered with all their important impacts and interactions. Science indicates that at most, a little warming will occur and certainly better plant grown which should be of great benefit to mankind. It was concluded that the human condition can be improved through unconstrained access to energy, but use of energy may also produce local unwanted pollutants as a by product. The sources of true environmental pollution can be mitigated based on rational considerations of the risks of pollutants and benefits of energy use. refs., figs

  4. Greenhouse gas emissions increase global warming

    OpenAIRE

    Mohajan, Haradhan

    2011-01-01

    This paper discusses the greenhouse gas emissions which cause the global warming in the atmosphere. In the 20th century global climate change becomes more sever which is due to greenhouse gas emissions. According to International Energy Agency data, the USA and China are approximately tied and leading global emitters of greenhouse gas emissions. Together they emit approximately 40% of global CO2 emissions, and about 35% of total greenhouse gases. The developed and developing industrialized co...

  5. Climate change and global warming potentials

    International Nuclear Information System (INIS)

    Vate, J.F. van de

    1996-01-01

    Climate change and the global budgets of the two main energy consumption related greenhouse gases, CO 2 and CH 4 , are discussed. The global warming potential (GWP) of the non-CO 2 greenhouse gases is defined and the large range of GWPs of CH 4 in the literature is discussed. GWPs are expected to play an important role in energy policies and negotiations concerning lowering greenhouse gas emissions. (author). 20 refs, 4 figs, 4 tabs

  6. Soft radiative strength in warm nuclei

    International Nuclear Information System (INIS)

    Becker, J A; Bernstein, L A; Garrett, P E; Nelson, R O; Schiller, A; Voinov, A; Agvaanluvsan, U; Algin, E; Belgya, T; Chankova, R; Guttormsen, M; Mitchell, G E; Rekstad, J; Siem, S

    2004-01-01

    Unresolved transitions in the nuclear γ-ray cascade produced in the decay of excited nuclei are best described by statistical concepts: a continuous radiative strength function (RSF) and level density yield mean values of transition matrix elements. Data on the soft (E γ < 3-4 MeV) RSF for transitions between warm states (i.e. states several MeV above the yrast line) have, however, remained elusive

  7. Global warming: Sea ice and snow cover

    International Nuclear Information System (INIS)

    Walsh, J.E.

    1993-01-01

    In spite of differences among global climate simulations under scenarios where atmospheric CO 2 is doubled, all models indicate at least some amplification of greenouse warming at the polar regions. Several decades of recent data on air temperature, sea ice, and snow cover of the high latitudes of the Northern Hemisphere are summarized to illustrate the general compatibility of recent variations in those parameters. Despite a data void over the Arctic Ocean, some noteworthy patterns emerge. Warming dominates in winter and spring, as projected by global climate models, with the warming strongest over subpolar land areas of Alaska, northwestern Canada, and northern Eurasia. A time-longitude summary of Arctic sea ice variations indicates that timescales of most anomalies range from several months to several years. Wintertime maxima of total sea ice extent contain no apparent secular trends. The statistical significance of trends in recent sea ice variations was evaluated by a Monte Carlo procedure, showing a statistically significant negative trend in the summer. Snow cover data over the 20-y period of record show a noticeable decrease of Arctic snow cover in the late 1980s. This is of potential climatic significance since the accompanying decrease of surface albedo leads to a rapid increase of solar heating. 21 refs., 3 figs., 1 tab

  8. Global Warming: Claims, Science, and Consequences

    Science.gov (United States)

    Gould, Laurence I.

    2007-04-01

    Widespread (and seemingly dominant) claims about the dire consequences of anthropogenic global warming (AGW) have been propagated by both scientists and politicians and have been prominently featured by much of the mass media. This talk will examine some of those claims --- such as those made in the popular pro-AGW film, An Inconvenient Truth^1 --- from the perspectives of science^2 and scientific methodology^3. Some of the issues considered will be: What are the major ``greenhouse gases''? To what extent is global warming a result of human influences through an increase of ``greenhouse gases''? Is an increase in (1) global temperature and (2) carbon dioxide bad/good? What are some meanings that can be given to the term ``consensus'' in science? What are the estimated financial and other costs of governments implementing the Kyoto accords? Links to readings and videos will be given at the conclusion of the talk. ^1Gore, Al, An Inconvenient Truth: The Planetary Emergency of Global Warming and What We Can Do About It -- (Rodale Press, May, 2006). ^2Marlo Lewis, ``A Skeptic's Guide to An Inconvenient Truth'' http://www.cei.org/pages/aitresponse-book.cfm ^3Aaron Wildavsky, But Is It True? A Citizen's Guide to Environmental Health and Safety Issues (Harvard University Press, 1995), Intro. and Chap. 11. To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2007.NES07.C1.6

  9. Climate. Meeting the challenge of global warming

    International Nuclear Information System (INIS)

    Masson-Delmotte, Valerie; Mann, Michael; Greene, Charles; Salas y Melia, David; Dufresne, Jean-Louis; Journe, Venance; Guegan, Jean-Francois; ); Bopp, Laurent; Magnan, Alexandre; Gattuso, Jean-Pierre; Bally, Rene; Duponnois, Robin; Giodda, Alain; MOATTI, JEAN-PAUL; Recio, Carlos; Santana, Luis; Hulot, Nicolas; Criqui, Patrick; Meritet, Sophie; Jacobson, Mark; Delucchi, Mark; Julliard, Romain; Balibar, Sebastien; Prevot, Anne-Caroline; Colleony, Agathe; Mangin, Loic

    2015-01-01

    The contributions of this publication first discuss and comment the cost of inaction in front of global warming. The authors deny the existence of a climate pause, explain the existence of harsh winters in Europe in the context of global warming, outline that models developed and used in the 1960 already predicted the present trend, discuss the complex relationships between climate change and health, outline the threats on the oceans (acidification, impact on marine species, level rise) and consequently on mankind. A second set of contributions addresses opportunities to be implemented now: to plant trees along the Sahara, the example of an ecologic island (El Hierro, Canaries Islands), the commitment of communities, associations and citizens, the necessary energy transition, innovation at the service of climate, the role of finances and investments. The third set of contributions addresses perspectives: to do without fossil energies, how to reduce the impact of global warming in cities (by planting trees and closing shutters), the emergence of participative science, arguments against climate sceptics, a difficult change of behaviours

  10. Is global warming mostly at night?

    International Nuclear Information System (INIS)

    Kukla, G.; Quayle, R.G.; Karl, T.

    1994-01-01

    The release of greenhouse gases is expected to lead to substantial future warming. The global mean temperature has indeed risen in recent decades. The causes of the observed warming, and its relation to the greenhouse gas buildup are, however, still debated. One important aspect of the observed temperature change relates to its asymmetry during the day and night. The day-night temperature difference over land in North America, most of Eurasia, Oceania, and portions of Africa and Australia shows a decrease since about 1950. The changes of the daily mean temperature in these areas are principally due to the rising night or early morning temperature, and are accompanied by increasing cloudiness. Their results support the notion that the increase of cloud cover, possibly due to industrial sulfur emissions, mitigates the greenhouse warming. The causes of the changing diurnal temperature range and of the increasing cloudiness will have to be clarified and the future SO 2 emissions reliably projected before any trustworthy prediction of future climates can be made. 37 refs., 7 figs., 2 tabs

  11. Toward international law on global warming

    International Nuclear Information System (INIS)

    Shultz, E.B. Jr.; Johns, C.; Pauken, M.T.

    1991-01-01

    Legal precedent in the history of international environmental law is considered. Then, the legal principles, rights and obligations related to transboundary environmental interference are drawn from the precedent. From this legal and historical background, and a brief overview of the principal technical aspects of the emerging global warming problem, the authors suggest a number of possible international protocols. These include outlines of multilateral treaties on energy efficiency, reduction in utilization of coal, increased adoption efficiency, reduction in utilization of coal, increased adoption of renewable and solar energy, and stimulation of several types of forestation, with creation of practical regimes and remedies. Each protocol has its own environmental social and economic merits and urgency, apart from the prevention of global warming. In each suggested protocol, the political obstacles are analyzed. Suggestions are presented for reduction of levels of disagreement standing in the way of obtaining viable treaties likely to be upheld in practice by the signatories. An agenda for study and action is presented, on the assumption that prudence dictates that international environmental law must be expanded as soon as feasible to regulate global warming

  12. Scientists' views about attribution of global warming.

    Science.gov (United States)

    Verheggen, Bart; Strengers, Bart; Cook, John; van Dorland, Rob; Vringer, Kees; Peters, Jeroen; Visser, Hans; Meyer, Leo

    2014-08-19

    Results are presented from a survey held among 1868 scientists studying various aspects of climate change, including physical climate, climate impacts, and mitigation. The survey was unique in its size, broadness and level of detail. Consistent with other research, we found that, as the level of expertise in climate science grew, so too did the level of agreement on anthropogenic causation. 90% of respondents with more than 10 climate-related peer-reviewed publications (about half of all respondents), explicitly agreed with anthropogenic greenhouse gases (GHGs) being the dominant driver of recent global warming. The respondents' quantitative estimate of the GHG contribution appeared to strongly depend on their judgment or knowledge of the cooling effect of aerosols. The phrasing of the IPCC attribution statement in its fourth assessment report (AR4)-providing a lower limit for the isolated GHG contribution-may have led to an underestimation of the GHG influence on recent warming. The phrasing was improved in AR5. We also report on the respondents' views on other factors contributing to global warming; of these Land Use and Land Cover Change (LULCC) was considered the most important. Respondents who characterized human influence on climate as insignificant, reported having had the most frequent media coverage regarding their views on climate change.

  13. National action strategy on global warming

    International Nuclear Information System (INIS)

    1990-11-01

    A document prepared by a committee of Canadian environmental ministries proposes a strategic framework for a national action plan concerning global warming. The strategy would be carried out jointly by governments and all other sectors of the economy, taking into account the present state of scientific knowledge on global warming. Within this framework, the governments in cooperation with interested parties would take certain measures in their respective areas of competence. The main recommendations of the document include the following. The action strategy should comprise 3 elements: limiting emissions of greenhouse gases; forecasting climatic changes which Canada could undergo due to global warming and preparing for such changes; and improving scientific knowledge and the capacity to predict climatic changes. Limitations on this strategy should take into account such matters as the interaction of greenhouse gases with other pollutants, the importance of the international context, the need to adapt to new discoveries, and the importance of regional differences. Implementation of the strategy should incorporate widespread consultation of all affected sectors, sustained work on establishing international conventions and protocols on reducing greenhouse gas emissions, objectives and schedules for such reductions, and stepwise actions to control emissions in order to enable an adequate evaluation of the consequences and effectiveness of such measures. 10 figs., 2 tabs

  14. Global Warming: Evidence from Satellite Observations

    Science.gov (United States)

    Prabhakara, C.; Iacovazzi, R., Jr.; Yoo, J.-M.

    2001-01-01

    Observations made in Channel 2 (53.74 GHz) of the Microwave Sounding Unit (MSU) radiometer, flown on-board sequential, sun-synchronous, polar orbiting NOAA operational satellites, indicate that the mean temperature of the atmosphere over the globe increased during the period 1980 to 1999. In this study we have minimized systematic errors in the time series introduced by the satellite orbital drift in an objective manner. This is done with the help the onboard warm black body temperature, which is used in the calibration of the MSU radiometer. The corrected MSU Channel 2 observations of the NOAA satellite series reveal that the vertically weighted global mean temperature of the atmosphere, with a peak weight near the mid-troposphere, warmed at the rate of 0.13 K per decade (with an uncertainty of 0.05 K per decade) during 1980 to 1999. The global warming deduced from conventional meteorological data that have been corrected for urbanization effects agrees reasonably with this satellite deuced result.

  15. Global warming and allergy in Asia Minor.

    Science.gov (United States)

    Bajin, Munir Demir; Cingi, Cemal; Oghan, Fatih; Gurbuz, Melek Kezban

    2013-01-01

    The earth is warming, and it is warming quickly. Epidemiological studies have demonstrated that global warming is correlated with the frequency of pollen-induced respiratory allergy and allergic diseases. There is a body of evidence suggesting that the prevalence of allergic diseases induced by pollens is increasing in developed countries, a trend that is also evident in the Mediterranean area. Because of its mild winters and sunny days with dry summers, the Mediterranean area is different from the areas of central and northern Europe. Classical examples of allergenic pollen-producing plants of the Mediterranean climate include Parietaria, Olea and Cupressaceae. Asia Minor is a Mediterranean region that connects Asia and Europe, and it includes considerable coastal areas. Gramineae pollens are the major cause of seasonal allergic rhinitis in Asia Minor, affecting 1.3-6.4 % of the population, in accordance with other European regions. This article emphasizes the importance of global climate change and anticipated increases in the prevalence and severity of allergic disease in Asia Minor, mediated through worsening air pollution and altered local and regional pollen production, from an otolaryngologic perspective.

  16. Effects of Global Warming on Vibrio Ecology.

    Science.gov (United States)

    Vezzulli, Luigi; Pezzati, Elisabetta; Brettar, Ingrid; Höfle, Manfred; Pruzzo, Carla

    2015-06-01

    Vibrio-related infections are increasing worldwide both in humans and aquatic animals. Rise in global sea surface temperature (SST), which is approximately 1 °C higher now than 140 years ago and is one of the primary physical impacts of global warming, has been linked to such increases. In this chapter, major known effects of increasing SST on the biology and ecology of vibrios are described. They include the effects on bacterial growth rate, both in the field and in laboratory, culturability, expression of pathogenicity traits, and interactions with aquatic organisms and abiotic surfaces. Special emphasis is given to the effect of ocean warming on Vibrio interactions with zooplankters, which represent one of the most important aquatic reservoirs for these bacteria. The reported findings highlight the biocomplexity of the interactions between vibrios and their natural environment in a climate change scenario, posing the need for interdisciplinary studies to properly understand the connection between ocean warming and persistence and spread of vibrios in sea waters and the epidemiology of the diseases they cause.

  17. Is Detrusor Contraction during Rapid Bladder Filling Caused by Cold or Warm Water? A Randomized, Controlled, Double-Blind Trial.

    Science.gov (United States)

    Kozomara, Marko; Mehnert, Ulrich; Seifert, Burkhardt; Kessler, Thomas M

    2018-01-01

    We investigated whether detrusor contraction during rapid bladder filling is provoked by cold or warm water. Patients with neurogenic lower urinary tract dysfunction were included in this randomized, controlled, double-blind trial. At the end of a standard urodynamic investigation patients underwent 2 bladder fillings using a 4C ice water test or a 36C warm water test saline solution at a filling speed of 100 ml per minute. The order was randomly selected, and patients and investigators were blinded to the order. The primary outcome measure was detrusor overactivity, maximum detrusor pressure and maximum bladder filling volume during the ice and warm water tests. Nine women and 31 men were the subject of data analysis. Neurogenic lower urinary tract dysfunction was caused by spinal cord injury in 33 patients and by another neurological disorder in 7. Irrespective of test order detrusor overactivity occurred significantly more often during the ice water test than during the warm water test (30 of 40 patients or 75% vs 25 of 40 or 63%, p = 0.02). When comparing the ice water test to the warm water test, maximum detrusor pressure was significantly higher and maximum bladder filling volume was significantly lower during the ice water test (each p warm water first) had no effect on the parameters. Our findings imply that the more frequent detrusor overactivity, higher maximum detrusor pressure and lower bladder filling volume during the ice water test compared to the warm water test were caused by cold water. This underlies the theory of a C-fiber mediated bladder cooling reflex in humans. Copyright © 2018 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  18. Warm-up and performance in competitive swimming.

    Science.gov (United States)

    Neiva, Henrique P; Marques, Mário C; Barbosa, Tiago M; Izquierdo, Mikel; Marinho, Daniel A

    2014-03-01

    Warm-up before physical activity is commonly accepted to be fundamental, and any priming practices are usually thought to optimize performance. However, specifically in swimming, studies on the effects of warm-up are scarce, which may be due to the swimming pool environment, which has a high temperature and humidity, and to the complexity of warm-up procedures. The purpose of this study is to review and summarize the different studies on how warming up affects swimming performance, and to develop recommendations for improving the efficiency of warm-up before competition. Most of the main proposed effects of warm-up, such as elevated core and muscular temperatures, increased blood flow and oxygen delivery to muscle cells and higher efficiency of muscle contractions, support the hypothesis that warm-up enhances performance. However, while many researchers have reported improvements in performance after warm-up, others have found no benefits to warm-up. This lack of consensus emphasizes the need to evaluate the real effects of warm-up and optimize its design. Little is known about the effectiveness of warm-up in competitive swimming, and the variety of warm-up methods and swimming events studied makes it difficult to compare the published conclusions about the role of warm-up in swimming. Recent findings have shown that warm-up has a positive effect on the swimmer's performance, especially for distances greater than 200 m. We recommend that swimmers warm-up for a relatively moderate distance (between 1,000 and 1,500 m) with a proper intensity (a brief approach to race pace velocity) and recovery time sufficient to prevent the early onset of fatigue and to allow the restoration of energy reserves (8-20 min).

  19. Glycogen synthase kinase 3β promotes liver innate immune activation by restraining AMP-activated protein kinase activation.

    Science.gov (United States)

    Zhou, Haoming; Wang, Han; Ni, Ming; Yue, Shi; Xia, Yongxiang; Busuttil, Ronald W; Kupiec-Weglinski, Jerzy W; Lu, Ling; Wang, Xuehao; Zhai, Yuan

    2018-02-13

    Glycogen synthase kinase 3β (Gsk3β [Gsk3b]) is a ubiquitously expressed kinase with distinctive functions in different types of cells. Although its roles in regulating innate immune activation and ischaemia and reperfusion injuries (IRIs) have been well documented, the underlying mechanisms remain ambiguous, in part because of the lack of cell-specific tools in vivo. We created a myeloid-specific Gsk3b knockout (KO) strain to study the function of Gsk3β in macrophages in a murine liver partial warm ischaemia model. Compared with controls, myeloid Gsk3b KO mice were protected from IRI, with diminished proinflammatory but enhanced anti-inflammatory immune responses in livers. In bone marrow-derived macrophages, Gsk3β deficiency resulted in an early reduction of Tnf gene transcription but sustained increase of Il10 gene transcription on Toll-like receptor 4 stimulation in vitro. These effects were associated with enhanced AMP-activated protein kinase (AMPK) activation, which led to an accelerated and higher level of induction of the novel innate immune negative regulator small heterodimer partner (SHP [Nr0b2]). The regulatory function of Gsk3β on AMPK activation and SHP induction was confirmed in wild-type bone marrow-derived macrophages with a Gsk3 inhibitor. Furthermore, we found that this immune regulatory mechanism was independent of Gsk3β Ser9 phosphorylation and the phosphoinositide 3-kinase-Akt signalling pathway. In vivo, myeloid Gsk3β deficiency facilitated SHP upregulation by ischaemia-reperfusion in liver macrophages. Treatment of Gsk3b KO mice with either AMPK inhibitor or SHP small interfering RNA before the onset of liver ischaemia restored liver proinflammatory immune activation and IRI in these otherwise protected hosts. Additionally, pharmacological activation of AMPK protected wild-type mice from liver IRI, with reduced proinflammatory immune activation. Inhibition of the AMPK-SHP pathway by liver ischaemia was demonstrated in tumour resection

  20. GLOBAL WARMING: IS A NEW THREAT?

    Energy Technology Data Exchange (ETDEWEB)

    Ayca Eminoglu

    2008-09-30

    In the Post Cold War era, the concepts of ''security'', ''national security'', and ''international security'' have changed with regard to their contents and meanings. Such developments made states to renew their national security policies. Security is a special form of politics as well. All security issues are political problems but not all political conflicts are security issues. In the Post Cold War era, differentiating and increasing numbers of elements that constitutes threat changed the concept of threat and widen the capacity of security. In this term, many elements lost its effect of being a threat but also new threatening elements emerged. Environmental problems, human rights, mass migration, micro nationalism, ethnic conflicts, religious fundamentalism, contagious diseases, international terrorism, economic instabilities, drug and weapon smuggling and human trafficking are the new problems emerged in international security agenda. Environmental problems no longer take place in security issues and can be mentioned as a ''low security'' issue. They are threats to the global commons i.e. the oceans, the seas, the ozone layer and the climate system, which are life supports for mankind as a whole. Global warming is one of the most important environmental issues of our day that effects human life in every field and can be defined as a 'serious threat to international security'. Because of global warming, environmental changes will occur and these changes will cause conflicting issues in international relations. Because of global warming dwindling freshwater supplies, food shortages, political instability and other conflicts may take place. Some IR scholars see a need for global cooperation in order to face the threat. At the background of global warming and its effects, states have to get preventive measures and normally, each state form its own measures, therefore as a

  1. Patterns of work injuries

    DEFF Research Database (Denmark)

    Lander, Flemming; Nielsen, Kent Jacob; Rasmussen, Kurt

    2014-01-01

    To compare work injuries treated in an emergency department (ED) and injuries reported to the Danish Working Environment Authority (DWEA).......To compare work injuries treated in an emergency department (ED) and injuries reported to the Danish Working Environment Authority (DWEA)....

  2. Sports-specific injuries.

    Science.gov (United States)

    Plancher, K D; Minnich, J M

    1996-04-01

    Injuries to the upper extremities can happen in any sport. Injury patterns are common to specific sports. Understanding which injuries occur with these sports allows the examiner to diagnose and treat the athlete easily. This article reviews some of the injuries common in sports such as bicycling, golf, gymnastics, martial arts, racquet sports, and weightlifting.

  3. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... injury? play_arrow How does the spinal cord work? play_arrow Why is the level of a spinal cord injury important? play_arrow What role does “compression” play in a spinal cord injury? play_arrow Why are high-dose steroids often used right after an injury? play_arrow What is meant ...

  4. Dietary red palm oil supplementation reduces myocardial infarct size in an isolated perfused rat heart model

    Directory of Open Access Journals (Sweden)

    Esterhuyse Adriaan J

    2010-06-01

    Full Text Available Abstract Background and Aims Recent studies have shown that dietary red palm oil (RPO supplementation improves functional recovery following ischaemia/reperfusion in isolated hearts. The main aim of this study was to investigate the effects of dietary RPO supplementation on myocardial infarct size after ischaemia/reperfusion injury. The effects of dietary RPO supplementation on matrix metalloproteinase-2 (MMP2 activation and PKB/Akt phosphorylation were also investigated. Materials and methods Male Wistar rats were divided into three groups and fed a standard rat chow diet (SRC, a SRC supplemented with RPO, or a SRC supplemented with sunflower oil (SFO, for a five week period, respectively. After the feeding period, hearts were excised and perfused on a Langendorff perfusion apparatus. Hearts were subjected to thirty minutes of normothermic global ischaemia and two hours of reperfusion. Infarct size was determined by triphenyltetrazolium chloride staining. Coronary effluent was collected for the first ten minutes of reperfusion in order to measure MMP2 activity by gelatin zymography. Results Dietary RPO-supplementation decreased myocardial infarct size significantly when compared to the SRC-group and the SFO-supplemented group (9.1 ± 1.0% versus 30.2 ± 3.9% and 27.1 ± 2.4% respectively. Both dietary RPO- and SFO-supplementation were able to decrease MMP2 activity when compared to the SRC fed group. PKB/Akt phosphorylation (Thr 308 was found to be significantly higher in the dietary RPO supplemented group when compared to the SFO supplemented group at 10 minutes into reperfusion. There was, however, no significant changes observed in ERK phosphorylation. Conclusions Dietary RPO-supplementation was found to be more effective than SFO-supplementation in reducing myocardial infarct size after ischaemia/reperfusion injury. Both dietary RPO and SFO were able to reduce MMP2 activity, which suggests that MMP2 activity does not play a major role in

  5. Why tropical forest lizards are vulnerable to climate warming

    Science.gov (United States)

    Huey, Raymond B.; Deutsch, Curtis A.; Tewksbury, Joshua J.; Vitt, Laurie J.; Hertz, Paul E.; Álvarez Pérez, Héctor J.; Garland, Theodore

    2009-01-01

    Biological impacts of climate warming are predicted to increase with latitude, paralleling increases in warming. However, the magnitude of impacts depends not only on the degree of warming but also on the number of species at risk, their physiological sensitivity to warming and their options for behavioural and physiological compensation. Lizards are useful for evaluating risks of warming because their thermal biology is well studied. We conducted macrophysiological analyses of diurnal lizards from diverse latitudes plus focal species analyses of Puerto Rican Anolis and Sphaerodactyus. Although tropical lowland lizards live in environments that are warm all year, macrophysiological analyses indicate that some tropical lineages (thermoconformers that live in forests) are active at low body temperature and are intolerant of warm temperatures. Focal species analyses show that some tropical forest lizards were already experiencing stressful body temperatures in summer when studied several decades ago. Simulations suggest that warming will not only further depress their physiological performance in summer, but will also enable warm-adapted, open-habitat competitors and predators to invade forests. Forest lizards are key components of tropical ecosystems, but appear vulnerable to the cascading physiological and ecological effects of climate warming, even though rates of tropical warming may be relatively low. PMID:19324762

  6. Managing eye injuries

    Directory of Open Access Journals (Sweden)

    Dorothy Mutie

    2016-01-01

    Full Text Available Based on what you found during the eye examination, classify the injury as a non-mechanical injury (chemical or thermal injury, a non-globe injury (orbital or adnexal injury or as a mechanical globe injury. In the case of mechanical globe injuries, it is important to classify the injury according to the Birmingham Eye Trauma Terminology System (BETTS and write it down in the patient’s notes; this will help to ensure that everyone involved in caring for the patient will have a consistent understanding of the type of injury. The resulting uniformity of terminology also helps with research, making it possible to compare data and do audits of injuries – which is essential for prevention.

  7. Global warming 2007. An update to global warming: the balance of evidence and its policy implications.

    Science.gov (United States)

    Keller, Charles F

    2007-03-09

    In the four years since my original review (Keller[25]; hereafter referred to as CFK03), research has clarified and strengthened our understanding of how humans are warming the planet. So many of the details highlighted in the IPCC's Third Assessment Report[21] and in CFK03 have been resolved that I expect many to be a bit overwhelmed, and I hope that, by treating just the most significant aspects of the research, this update may provide a road map through the expected maze of new information. In particular, while most of CFK03 remains current, there are important items that have changed: Most notable is the resolution of the conundrum that mid-tropospheric warming did not seem to match surface warming. Both satellite and radiosonde (balloon-borne sensors) data reduction showed little warming in the middle troposphere (4-8 km altitude). In the CFK03 I discussed potential solutions to this problem, but at that time there was no clear resolution. This problem has now been solved, and the middle troposphere is seen to be warming apace with the surface. There have also been advances in determinations of temperatures over the past 1,000 years showing a cooler Little Ice Age (LIA) but essentially the same warming during medieval times (not as large as recent warming). The recent uproar over the so-called "hockey stick" temperature determination is much overblown since at least seven other groups have made relatively independent determinations of northern hemisphere temperatures over the same time period and derived essentially the same results. They differ on how cold the LIA was but essentially agree with the Mann's hockey stick result that the Medieval Warm Period was not as warm as the last 25 years. The question of the sun's influence on climate continues to generate controversy. It appears there is a growing consensus that, while the sun was a major factor in earlier temperature variations, it is incapable of having caused observed warming in the past quarter

  8. LATERAL ANKLE INJURY

    OpenAIRE

    Pollard, Henry; Sim, Patrick; McHardy, Andrew

    2002-01-01

    Background: Injury to the ankle joint is the most common peripheral joint injury. The sports that most commonly produce high ankle injury rates in their participating athletes include: basketball, netball, and the various codes of football. Objective: To provide an up to date understanding of manual therapy relevant to lateral ligament injury of the ankle. A discussion of the types of ligament injury and common complicating factors that present with lateral ankle pain is presented along with ...

  9. Effect of donor fasting on survival of pancreas and heart grafts after warm ischemia.

    Science.gov (United States)

    Nishihara, M; Sumimoto, R; Asahara, T; Fukuda, Y; Southard, J H; Dohi, K

    1996-09-01

    Livers from fasted animals are believed to be more vulnerable to ischemic injury than those from fed donors. However, we have recently shown the opposite: livers from fasted rats were more tolerant to ischemic injury. Indeed, the survival rate of 60 min warm ischemic damaged livers increased from 0 to 90% if donor rats were fasted for three days. In this study, we examined how donor fasting affects the outcome of pancreas and heart preservation. BN rats were used as both donors and recipients, and recipients of pancreatic grafts were rendered diabetic prior to transplantation. Pancreatic or heart grafts were subjected to 90 min or 25 min of warm ischemia and were transplanted into the right side of the necks of recipients rats. The viability rate of hearts transplanted from fed donors into fed recipients was only about 11% (1/9) after transplantation. However, the viability rate with fasted donors was 75% (6/8). The rate of successful pancreatic grafting from fed donors into fed recipients was 28.6% (2/7), and that from fasted donors to fed recipients was 41.7% (5/12). These results confirm that the nutritional status of the donor is an important factor in the outcome of not only liver, but also pancreas and heart preservation during transplantation, although the effect of fasting on pancreatic graft is marginal.

  10. Can air pollutant controls change global warming?

    International Nuclear Information System (INIS)

    Strefler, Jessica; Luderer, Gunnar; Kriegler, Elmar; Meinshausen, Malte

    2014-01-01

    Highlights: • Air pollution policies do not affect long-term climate targets. • Reduction of aerosols counteracts a fraction of the reduction of Kyoto forcing. • Air pollution policies may affect the rate of climate change in the short term. • There is no tradeoff between clean air and climate policies. - Abstract: In this paper we analyze the interaction between climate and air pollution policies using the integrated assessment model REMIND coupled to the reduced-form climate model MAGICC. Since overall, aerosols tend to cool the atmosphere, there is a concern that a reduction of pollutant emissions could accelerate global warming and offset the climate benefits of carbon dioxide emission reductions. We investigate scenarios which independently reduce emissions from either large-scale sources, such as power plants, or small-scale sources, such as cooking and heating stoves. Large-scale sources are likely to be easier to control, but their aerosol emissions are characterized by a relatively high sulfur content, which tends to result in atmospheric cooling. Pollution from small-scale sources, by contrast, is characterized by a high share of carbonaceous aerosol, which is an important contributor to global warming. We find that air pollution policies can significantly reduce aerosol emissions when no climate policies are in place. Stringent climate policies lead to a large reduction of fossil fuel use, and therefore result in a concurrent reduction of air pollutant emissions. These reductions partly reduce aerosol masking, thus initially counteracting the reduction of greenhouse gas forcing, however not overcompensating it. If climate policies are in place, air pollution policies have almost no impacts on medium- and long-term radiative forcing. Therefore there is no conflict of objectives between clean air and limiting global warming. We find that the stringency of air pollution policies may influence the rate of global temperature change in the first decade

  11. Can global warming save nuclear power?

    International Nuclear Information System (INIS)

    Pearce, D.

    1994-01-01

    Nuclear powered electricity generation in the United Kingdom has an uncertain future. The relative costs of generating electricity by nuclear fission compared to other means and the need for a desirable mixture or ''portfolio'' of energy sources in the electricity industry are identified as the key to this uncertainty. The author argues that Government commitments to reducing Carbon Monoxide (CO) emissions, and hence global warming, may strengthen arguments in favour of a firm commitment to nuclear power, as even modern fossil-fuelled power plants emit nearly 90 times as much CO as nuclear plants. (UK)

  12. Marine ecosystems in alteration under global warming

    International Nuclear Information System (INIS)

    Prestrud, Paal

    2004-01-01

    It is commonly thought among fishermen, researchers and in the fishing industries that the administration and harvesting of the fish resources is more important for the stock of fish than are changes in the climate. However, many scientific investigations now link changes in temperature with changes in the spreading, survival and beginning of life processes. There is solid evidence that there are important changes in progress in the North Atlantic marine ecosystem caused by global warming. If the heating of the water masses continues, it will probably have a large impact on the ocean's productivity and consequently for the fishing industry

  13. Resource Letter: GW-1: Global warming

    Science.gov (United States)

    Firor, John W.

    1994-06-01

    This Resource Letter provides a guide to the literature on the possibility of a human-induced climate change—a global warming. Journal articles and books are cited for the following topics: the Greenhouse Effect, sources of infrared-trapping gases, climate models and their uncertainties, verification of climate models, past climate changes, and economics, ethics, and politics of policy responses to climate change. [The letter E after an item indicates elementary level or material of general interest to persons becoming informed in the field. The letter I, for intermediate level, indicates material of somewhat more specialized nature, and the letter A indicates rather specialized or advanced material.

  14. Scientists' Views about Attribution of Global Warming

    Science.gov (United States)

    Verheggen, Bart; Strengers, Bart; Cook, John; van Dorland, Rob; Vringer, Kees; Peters, Jeroen; Visser, Hans; Meyer, Leo

    2015-04-01

    What do scientists think? That is an important question when engaging in science communication, in which an attempt is made to communicate the scientific understanding to a lay audience. To address this question we undertook a large and detailed survey among scientists studying various aspects of climate change , dubbed "perhaps the most thorough survey of climate scientists ever" by well-known climate scientist and science communicator Gavin Schmidt. Among more than 1800 respondents we found widespread agreement that global warming is predominantly caused by human greenhouse gases. This consensus strengthens with increased expertise, as defined by the number of self-reported articles in the peer-reviewed literature. 90% of respondents with more than 10 climate-related peer-reviewed publications (about half of all respondents), agreed that anthropogenic greenhouse gases are the dominant cause of recent global warming, i.e. having contributed more than half of the observed warming. With this survey we specified what the consensus position entails with much greater specificity than previous studies. The relevance of this consensus for science communication will be discussed. Another important result from our survey is that the main attribution statement in IPCC's fourth assessment report (AR4) may lead to an underestimate of the greenhouse gas contribution to warming, because it implicitly includes the lesser known masking effect of cooling aerosols. This shows the importance of the exact wording in high-profile reports such as those from IPCC in how the statement is perceived, even by fellow scientists. The phrasing was improved in the most recent assessment report (AR5). Respondents who characterized the human influence on climate as insignificant, reported having the most frequent media coverage regarding their views on climate change. This shows that contrarian opinions are amplified in the media in relation to their prevalence in the scientific community. This

  15. An observational study on the temperature rising effects in water warming canal and water warming pond

    Energy Technology Data Exchange (ETDEWEB)

    Hong, J. B.; Hong, S. B. [Rural Development Cooperation, Seoul (Korea, Republic of)

    1990-09-15

    The power water flowed out from the multipurpose darn influences the ecosystem approximately because of the low water temperature. An appropriate counter measure to the rising water temperature is needed for growing crops especially when the temperature is below 18°C in the source of the irrigation water This observational study is practiced in Yong-Doo water warming canal and pond in the down stream of Choong-Ju multipurpose dam and is practiced for analyse and compare the rising effects in actural water temperature by actual measurement with the rising effects of planned water temperatuer by the basic theoritical method and for the help to present the direction in plan establishment through investigate the results afterwards. The results are as follows. 1. The degree of the rise of the water temperature can be decided by θ{sub x} = θ{sub 0} + K (L/(v * h)) * (T - θ{sub 0}) Then, K values of a factor representing the characteristics of the water warming canal were 0.00002043 for the type I. and 0.0000173 for the type II. respectively. 2. A variation of water temperature which produced by the difference effective temperature and water temperature in the water warming canal was θ{sub x1} = 16.5 + 15.9 (1-e{sup -0.00018x}), θ{sub x2} = 18.8 + 8.4(1-e{sup -0.000298x}) for the type I. and θ{sub x} = 19.6 + 12.8 (1-e{sup -0.00041x}) for the type II. 3. It was shown that the effects of the rise of water temperature for the type I. water warming canal were greater than that of type II. as a resultes of broadening the surface of the canal compared with the depth of water, coloring the surface of water canal and installing the resistance block. 4. In case of the type I. water warming canal, the equation between the air temperature and the degree of the rise of water temprature could be made; Y = 0.4134X + 7.728 In addition, in case of the type II. water warming canal, the correlation was very low. 5. A monthly variation of the water temperature in the water warming

  16. An Investigation of Knee Injury Prevalence and its Mechanism among Premier League Soccer Referees in Iran

    Directory of Open Access Journals (Sweden)

    Hamid Mahdavi Mohtasham

    2017-03-01

    Conclusion: The results of this study highlight the importance of including special training in warm-up programs such as interval training, proprioception exercises, strength training (e.g. Nordic hamstring, flexibility training, and muscular endurance training which have been designed to prevent knee injuries. The results help to design and set-up an injury prevention program for the Referees Committee of the Iranian Football Federation.

  17. Uses of warmed water in agriculture. Final report

    International Nuclear Information System (INIS)

    Garrett, R.E.

    1978-11-01

    Energy in the form of warmed water is available from condenser cooling water from fossil fuel or nuclear-electric power-generating facilities, geothermal power plants, geothermal fluids, or spent steam and cooling water from industrial processes. A re-analysis of the characteristics of possible agricultural uses of warmed water has revealed the need to decouple considerations of warmed water sources from those of warmed water users. Conflicting objectives and managerial requirements seem to preclude an integrated system approach. Rather an interface must be established with separate costs and benefits identified for a reliable warmed water source and for its various potential uses. These costs and benefits can be utilized as a basis for decisions separately by the energy supplier and the prospective energy users. A method of classifying uses of warmed water according to need, volume, objective, temperature, and quality is presented and preliminary classifications are discussed for several potential agricultural uses of warmed water. Specific uses for soil warming, space heating in greenhouses, and irrigation are noted. Specific uses in aquaculture for catfish, lobster, and prawn production are discussed. Warmed water use in animal shelters is mentioned. Low-quality heat is required for methane generation from biomass and warmed water heating could be utilized in this industry. 53 references

  18. The role of perioperative warming in surgery: a systematic review

    Directory of Open Access Journals (Sweden)

    Muhammad Shafique Sajid

    Full Text Available OBJECTIVE: The objective of this review was to systematically analyze the trials on the effectiveness of perioperative warming in surgical patients. METHODS: A systematic review of the literature was undertaken. Clinical trials on perioperative warming were selected according to specific criteria and analyzed to generate summative data expressed as standardized mean difference (SMD. RESULTS: Twenty-five studies encompassing 3,599 patients in various surgical disciplines were retrieved from the electronic databases. Nineteen randomized trials on 1785 patients qualified for this review. The no-warming group developed statistically significant hypothermia. In the fixed effect model, the warming group had significantly less pain and lower incidence of wound infection, compared with the no-warming group. In the random effect model, the warming group was also associated with lower risk of post-anesthetic shivering. Both in the random and the fixed effect models, the warming group was associated with significantly less blood loss. However, there was significant heterogeneity among the trials. CONCLUSION: Perioperative warming of surgical patients is effective in reducing postoperative wound pain, wound infection and shivering. Systemic warming of the surgical patient is also associated with less perioperative blood loss through preventing hypothermia-induced coagulopathy. Perioperative warming may be given routinely to all patients of various surgical disciplines in order to counteract the consequences of hypothermia.

  19. [Sport injuries in full contact and semi-contact karate].

    Science.gov (United States)

    Greier, K; Riechelmann, H; Ziemska, J

    2014-03-01

    Karate enjoys great popularity both in professional and recreational sports and can be classified into full, half and low contact styles. The aim of this study was the analysis of sports injuries in Kyokushinkai (full contact) and traditional Karate (semi-contact). In a retrospective study design, 215 active amateur karateka (114 full contact, 101 semi-contact) were interviewed by means of a standardised questionnaire regarding typical sport injuries during the last 36 months. Injuries were categorised into severity grade I (not requiring medical treatment), grade II (single medical treatment), grade III (several outpatient medical treatments) and grade IV (requiring hospitalisation). In total, 217 injuries were reported in detail. 125 injuries (58%) occurred in full contact and 92 (42%) in semi-contact karate. The time related injury rate of full contact karateka was 1.9/1000 h compared to 1.3/1000 h of semi-contact karateka (p injuries were musculoskeletal contusions (33% full contact, 20% semi-contact), followed by articular sprains with 19% and 16%. The lower extremity was affected twice as often in full contact (40%) as in semi-contact (20%) karate. Training injuries were reported by 80% of the full contact and 77% of the semi-contact karateka. Most injuries, both in training and competition, occurred in kumite. 75% of the reported injuries of full contact and 70% of semi-contact karateka were classified as low grade (I or II). The high rate of injuries during training and kumite (sparring) points to specific prevention goals. The emphasis should be put on proprioceptive training and consistent warm-up. In the actual competition the referees play a vital role regarding prevention. © Georg Thieme Verlag KG Stuttgart · New York.

  20. Blunt gastric injuries.

    Science.gov (United States)

    Oncel, Didem; Malinoski, Darren; Brown, Carlos; Demetriades, Demetrios; Salim, Ali

    2007-09-01

    Gastric rupture after blunt abdominal trauma is a rare injury with few reports in the literature. The purpose of this study was to review our experience with blunt gastric injuries and compare outcomes with small bowel or colon injuries. All patients with hollow viscus perforations after blunt abdominal trauma from 1992 to 2005 at our level I trauma center were reviewed. Of 35,033 blunt trauma admissions, there were 268 (0.7%) patients with a total of 319 perforating hollow viscus injuries, 25 (0.07%) of which were blunt gastric injuries. When compared with the small bowel or colon injuries, the blunt gastric injury group had a higher Injury Severity Score (22 versus 17, P = 0.04), more patients with a chest Abbreviated Injury Score greater than 2 (36% versus 12%, P < 0.01), and a shorter interval from injury to laparotomy (221 versus 366 minutes, P = 0.017). Multivariate analysis identified five independent risk factors for mortality: age older than 55 years, head Abbreviated Injury Score greater than 2, chest Abbreviated Injury Score greater than 2, the presence of hypotension on admission, and Glasgow Coma Scale 8 or less. The results of this study suggest that mortality in patients with blunt hollow viscus injuries can be attributed to concurrent head and chest injuries, but not the specific hollow viscus organ that is injured.

  1. Recently amplified arctic warming has contributed to a continual global warming trend

    Science.gov (United States)

    Huang, Jianbin; Zhang, Xiangdong; Zhang, Qiyi; Lin, Yanluan; Hao, Mingju; Luo, Yong; Zhao, Zongci; Yao, Yao; Chen, Xin; Wang, Lei; Nie, Suping; Yin, Yizhou; Xu, Ying; Zhang, Jiansong

    2017-12-01

    The existence and magnitude of the recently suggested global warming hiatus, or slowdown, have been strongly debated1-3. Although various physical processes4-8 have been examined to elucidate this phenomenon, the accuracy and completeness of observational data that comprise global average surface air temperature (SAT) datasets is a concern9,10. In particular, these datasets lack either complete geographic coverage or in situ observations over the Arctic, owing to the sparse observational network in this area9. As a consequence, the contribution of Arctic warming to global SAT changes may have been underestimated, leading to an uncertainty in the hiatus debate. Here, we constructed a new Arctic SAT dataset using the most recently updated global SATs2 and a drifting buoys based Arctic SAT dataset11 through employing the `data interpolating empirical orthogonal functions' method12. Our estimate of global SAT rate of increase is around 0.112 °C per decade, instead of 0.05 °C per decade from IPCC AR51, for 1998-2012. Analysis of this dataset shows that the amplified Arctic warming over the past decade has significantly contributed to a continual global warming trend, rather than a hiatus or slowdown.

  2. Impact of biofuels on contrail warming

    Science.gov (United States)

    Caiazzo, Fabio; Agarwal, Akshat; Speth, Raymond L.; Barrett, Steven R. H.

    2017-11-01

    Contrails and contrail-cirrus may be the largest source of radiative forcing (RF) attributable to aviation. Biomass-derived alternative jet fuels are a potentially major way to mitigate the climate impacts of aviation by reducing lifecycle CO2 emissions. Given the up to 90% reduction in soot emissions from paraffinic biofuels, the potential for a significant impact on contrail RF due to the reduction in contrail-forming ice nuclei (IN) remains an open question. We simulate contrail formation and evolution to quantify RF over the United States under different emissions scenarios. Replacing conventional jet fuels with paraffinic biofuels generates two competing effects. First, the higher water emissions index results in an increase in contrail occurrence (~ +8%). On the other hand, these contrails are composed of larger diameter crystals (~ +58%) at lower number concentrations (~ -75%), reducing both contrail optical depth (~ -29%) and albedo (~ -32%). The net changes in contrail RF induced by switching to biofuels range from -4% to +18% among a range of assumed ice crystal habits (shapes). In comparison, cleaner burning engines (with no increase in water emissions index) result in changes to net contrail RF ranging between -13% and +5% depending on habit. Thus, we find that even 67% to 75% reductions in aircraft soot emissions are insufficient to substantially reduce warming from contrails, and that the use of biofuels may either increase or decrease contrail warming—contrary to previous expectations of a significant decrease in warming.

  3. Canada and global warming: Meeting the challenge

    International Nuclear Information System (INIS)

    1991-01-01

    Canada accounts for ca 2% of total world emissions of greenhouse gases. Carbon dioxide emissions are by far the largest greenhouse gas source in Canada, primarily from energy consumption. On a per capita basis, Canada ranks second among industrialized countries in terms of energy related carbon dioxide emissions. Canada's northern geography and climate, its export-oriented economy with energy-intensive resource industries, and its relatively small population dispersed over a wide land mass contribute to this high per-capita value. The effects of global warming induced by greenhouse gases are outlined, including a reduction in water supplies, droughts affecting agriculture and forestry, and large-scale thawing of permafrost. A national strategy to respond to global warming has been developed which includes limiting and reducing greenhouse gas emissions, preparing for potential climatic changes, and improving scientific understanding and predictive capabilities with respect to climate change. Details of this strategy are outlined, including provincial and territorial strategies in partnership with the national strategy. 11 figs., 2 tabs

  4. Climate warming: what we can actually expect

    International Nuclear Information System (INIS)

    Delbecq, Denis; Lemarchand, Fabienne; Boucher, Olivier; Dessus, Benjamin; Laponche, Bernard; Le Treut, Herve

    2013-01-01

    As the next IPCC (Intergovernmental Panel on Climate Change) report is soon to be published, a paleo-climatologist answers few questions about issues related to climate change (recent climate events, slower temperature increase during the past ten years, lessons learned from the previous IPCC report, evolutions of models, remaining opportunities to limit temperature increase to 2 degrees). A second article comments climate modelling improvements (finer description of oceans, atmosphere and ice field, introduction of new mechanisms in IPCC models such as carbon cycle, vegetation evolution, aerosols and atmospheric chemistry, models relying on greenhouse gas emission principles and not on socioeconomic scenarios any longer). A third article outlines that Earth has never been so warm since 1850 and proposes some explanations about the fact that warming has slowed down during the last ten years. A fourth article discusses how greenhouse gas emissions can be reduced, notices that their accounting underestimates the short-term and medium-term impact of methane emission reduction, and stresses the importance of an increased attention to methane emissions

  5. Identifying the Molecular Origin of Global Warming

    Science.gov (United States)

    Bera, Partha P.; Francisco, Joseph S.; Lee, Timothy J.

    2009-01-01

    We have investigated the physical characteristics of greenhouse gases (GHGs) to assess which properties are most important in determining the efficiency of a GHG. Chlorofluorcarbons (CFCs), hydrofluorocarbons (HFCs), perfluorocarbons (PFCs), nitrogen fluorides, and various other known atmospheric trace molecules have been included in this study. Compounds containing the halogens F or Cl have in common very polar X-F or X-Cl bonds, particularly the X-F bonds. It is shown that as more F atoms bond to the same central atom, the bond dipoles become larger as a result of the central atom becoming more positive. This leads to a linear increase in the total or integrated XF bond dipole derivatives for the molecule, which leads to a non-linear (quadratic) increase in infrared (IR) intensity. Moreover, virtually all of the X-F bond stretches occur in the atmospheric IR window as opposed to X-H stretches, which do not occur in the atmospheric window. It is concluded that molecules possessing several F atoms will always have a large radiative forcing parameter in the calculation of their global warming potential. Some of the implications for global warming and climate change are discussed.

  6. What if mankind warms the earth

    International Nuclear Information System (INIS)

    Kellogg, W.W.

    1977-01-01

    There are a variety of human activities that are being pursued on such a large scale that they may influence regional and global climate. Virtually all of these activities, including the addition of carbon dioxide and particles to the atmosphere, are expected on theoretical grounds to cause an increase in mean surface temperature in the decades ahead, and by 2000 AD the total warming effect will probably be larger than any of the natural climate fluctuations during the past 1,000 years or more. It is therefore pertinent ot inquire what a warmer earth might be like; and to obtain a first rough answer we turn to our mathematical models of the atmosphere, and also to the conditions that have been deduced for the period about 4,000 to 8,000 years ago when the earth was apparently several degress warmer the now. Atan now. At that time some areas that are now subtropical deserts received more rainfall, and there were other areas in the middle latitudes that were drier. There are several important implications for society if mankind does succeed in warming the earth - and a number of still unanswered questions as well. (orig.) [de

  7. Anthropogenic warming exacerbates European soil moisture droughts

    Science.gov (United States)

    Samaniego, L.; Thober, S.; Kumar, R.; Wanders, N.; Rakovec, O.; Pan, M.; Zink, M.; Sheffield, J.; Wood, E. F.; Marx, A.

    2018-05-01

    Anthropogenic warming is anticipated to increase soil moisture drought in the future. However, projections are accompanied by large uncertainty due to varying estimates of future warming. Here, using an ensemble of hydrological and land-surface models, forced with bias-corrected downscaled general circulation model output, we estimate the impacts of 1-3 K global mean temperature increases on soil moisture droughts in Europe. Compared to the 1.5 K Paris target, an increase of 3 K—which represents current projected temperature change—is found to increase drought area by 40% (±24%), affecting up to 42% (±22%) more of the population. Furthermore, an event similar to the 2003 drought is shown to become twice as frequent; thus, due to their increased occurrence, events of this magnitude will no longer be classified as extreme. In the absence of effective mitigation, Europe will therefore face unprecedented increases in soil moisture drought, presenting new challenges for adaptation across the continent.

  8. Dynamics of polynomial Chaplygin gas warm inflation

    Energy Technology Data Exchange (ETDEWEB)

    Jawad, Abdul [COMSATS Institute of Information Technology, Department of Mathematics, Lahore (Pakistan); Chaudhary, Shahid [Sharif College of Engineering and Technology, Department of Mathematics, Lahore (Pakistan); Videla, Nelson [Pontificia Universidad Catolica de Valparaiso, Instituto de Fisica, Valparaiso (Chile)

    2017-11-15

    In the present work, we study the consequences of a recently proposed polynomial inflationary potential in the context of the generalized, modified, and generalized cosmic Chaplygin gas models. In addition, we consider dissipative effects by coupling the inflation field to radiation, i.e., the inflationary dynamics is studied in the warm inflation scenario. We take into account a general parametrization of the dissipative coefficient Γ for describing the decay of the inflaton field into radiation. By studying the background and perturbative dynamics in the weak and strong dissipative regimes of warm inflation separately for the positive and negative quadratic and quartic potentials, we obtain expressions for the most relevant inflationary observables as the scalar power spectrum, the scalar spectral, and the tensor-to-scalar ratio. We construct the trajectories in the n{sub s}-r plane for several expressions of the dissipative coefficient and compare with the two-dimensional marginalized contours for (n{sub s}, r) from the latest Planck data. We find that our results are in agreement with WMAP9 and Planck 2015 data. (orig.)

  9. Acting green elicits a literal warm glow

    Science.gov (United States)

    Taufik, Danny; Bolderdijk, Jan Willem; Steg, Linda

    2015-01-01

    Environmental policies are often based on the assumption that people only act environmentally friendly if some extrinsic reward is implicated, usually money. We argue that people might also be motivated by intrinsic rewards: doing the right thing (such as acting environmentally friendly) elicits psychological rewards in the form of positive feelings, a phenomenon known as warm glow. Given the fact that people's psychological state may affect their thermal state, we expected that this warm glow could express itself quite literally: people who act environmentally friendly may perceive the temperature to be higher. In two studies, we found that people who learned they acted environmentally friendly perceived a higher temperature than people who learned they acted environmentally unfriendly. The underlying psychological mechanism pertains to the self-concept: learning you acted environmentally friendly signals to yourself that you are a good person. Together, our studies show that acting environmentally friendly can be psychologically rewarding, suggesting that appealing to intrinsic rewards can be an alternative way to encourage pro-environmental actions.

  10. Warm water upwelling in the Cenozoic Era

    Science.gov (United States)

    Zhang, Y.

    2017-12-01

    Modern observations show that the occurrence of wind-driven upwelling is often tied to cold sea surface temperatures (SSTs). However, SST reconstructions indicate that globally, the upwelling regions were much warmer in the Miocene and Pliocene. This questions the overall strength of deep-water upwelling in the geological past, with important implications for the associated atmospheric, climatic and biogeochemical processes, and the fate of upwelling regions in a high-CO2 world. We recently showed that the eastern equatorial Pacific (EEP) was characterized by strong air-sea disequilibrium of CO2 during the late Miocene - Pliocene. Combined with export productivity proxies, we interpreted these as signs of vigorous upwelling. The upwelled waters were nutrient- and CO2-rich, but warm. The cause of the "excess" warming in the upwelling regions is linked to the source waters which originated from the higher latitudes. In other words, the reduced east (upwelling) to west (non-upwelling) temperature gradients along the equator in major ocean basins are rooted in the reduced meridional temperature gradients. To further test this hypothesis, we examine the history of the EEP and temperature gradients during the even-warmer Eocene - middle Miocene.

  11. The carbon cycle and global warming

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    Five land-use-based approaches can be used to slow the buildup of CO 2 in the atmosphere: slowing or stopping the loss of existing forests, thus preserving current carbon reservoirs; adding to the planet's vegetative cover through reforestation or other means, thus enlarging living terrestrial carbon reservoirs; increasing the carbon stored in nonliving carbon reservoirs such as agricultural soils; increasing the carbon stored in artificial reservoirs, including timber products; and substituting sustainable biomass energy sources for fossil fuel consumption, thus reducing energy-related carbon emissions. These approaches are all based on the same basic premise: adding to the planet's net carbon stores in vegetative cover or soil, or preventing any net loss, will help moderate global warming by keeping atmospheric CO 2 levels lower than they would otherwise be. Because biotic policy options appear capable of contributing significantly to the mitigation of global warming while also furthering many other public policy objectives, their role deserves careful consideration on a country-by-country basis

  12. Ethical choices and global climate warming

    Energy Technology Data Exchange (ETDEWEB)

    Dotto, L

    1994-01-01

    The ethical implications of global warming are discussed, and a summary is presented of a study on ethics and climate change. Deciding the 'best' approaches depends on point of view, whether this be of a Canadian, a Somali, great grandchildren, the Amazon rain forest or a kangaroo. The spectrum of possible actions runs from avoidance to adaptation. Avoidance focuses on strategies to reduce the greenhouse effect by curtailing greenhouse gas emissions or preventing these emissions from reaching the atmosphere. Adaptation strategies help to cope with the negative consequences of allowing emissions to continue. Philosophers and ethicists have expressed a wide range of opinions on the consequences, responsibilities, limitations, and legal mechanisms involved in determining global warming action. A profound shift in corporate thinking is called for, with less emphasis on short-term bottom line. The role of governments and other institutions is debated, and questions are raised about the economic strategies that will best protect the interests of future generations. Energy efficiency and conservation must be reflected in the economic equation. Public cynicism with regard to political leaders is such that they are unlikely to credited with any degree of ethical motivation, a view that may be unwarranted. Ethical principles must become more central in the formulation of policies.

  13. Urological injuries following trauma

    International Nuclear Information System (INIS)

    Bent, C.; Iyngkaran, T.; Power, N.; Matson, M.; Hajdinjak, T.; Buchholz, N.; Fotheringham, T.

    2008-01-01

    Blunt renal trauma is the third most common injury in abdominal trauma following splenic and hepatic injuries, respectively. In the majority, such injuries are associated with other abdominal organ injuries. As urological injuries are not usually life-threatening, and clinical signs and symptoms are non-specific, diagnosis is often delayed. We present a practical approach to the diagnosis and management of these injuries based on our experience in a busy inner city trauma hospital with a review of the current evidence-based practice. Diagnostic imaging signs are illustrated

  14. Urological injuries following trauma

    Energy Technology Data Exchange (ETDEWEB)

    Bent, C. [Department of Diagnostic Imaging, Barts and The London NHS Trust, London (United Kingdom)], E-mail: clare.bent@bartsandthelondon.nhs.uk; Iyngkaran, T.; Power, N.; Matson, M. [Department of Diagnostic Imaging, Barts and The London NHS Trust, London (United Kingdom); Hajdinjak, T.; Buchholz, N. [Department of Urology, Barts and The London NHS Trust, London (United Kingdom); Fotheringham, T. [Department of Diagnostic Imaging, Barts and The London NHS Trust, London (United Kingdom)

    2008-12-15

    Blunt renal trauma is the third most common injury in abdominal trauma following splenic and hepatic injuries, respectively. In the majority, such injuries are associated with other abdominal organ injuries. As urological injuries are not usually life-threatening, and clinical signs and symptoms are non-specific, diagnosis is often delayed. We present a practical approach to the diagnosis and management of these injuries based on our experience in a busy inner city trauma hospital with a review of the current evidence-based practice. Diagnostic imaging signs are illustrated.

  15. Spinal injury in sport

    Energy Technology Data Exchange (ETDEWEB)

    Barile, Antonio [Department of Radiology, University of L' Aquila, S. Salvatore Hospital, Via Vetoio, Coppito, 67100 L' Aquila (Italy)]. E-mail: antonio.barile@cc.univaq.it; Limbucci, Nicola [Department of Radiology, University of L' Aquila, S. Salvatore Hospital, Via Vetoio, Coppito, 67100 L' Aquila (Italy); Splendiani, Alessandra [Department of Radiology, University of L' Aquila, S. Salvatore Hospital, Via Vetoio, Coppito, 67100 L' Aquila (Italy); Gallucci, Massimo [Department of Radiology, University of L' Aquila, S. Salvatore Hospital, Via Vetoio, Coppito, 67100 L' Aquila (Italy); Masciocchi, Carlo [Department of Radiology, University of L' Aquila, S. Salvatore Hospital, Via Vetoio, Coppito, 67100 L' Aquila (Italy)

    2007-04-15

    Spinal injuries are very common among professional or amateur athletes. Spinal sport lesions can be classified in overuse and acute injuries. Overuse injuries can be found after years of repetitive spinal load during sport activity; however specific overuse injuries can also be found in adolescents. Acute traumas are common in contact sports. Most of the acute injuries are minor and self-healing, but severe and catastrophic events are possible. The aim of this article is to review the wide spectrum of spinal injuries related to sport activity, with special regard to imaging finding.

  16. Trauma: Spinal Cord Injury.

    Science.gov (United States)

    Eckert, Matthew J; Martin, Matthew J

    2017-10-01

    Injuries to the spinal column and spinal cord frequently occur after high-energy mechanisms of injury, or with lower-energy mechanisms, in select patient populations like the elderly. A focused yet complete neurologic examination during the initial evaluation will guide subsequent diagnostic procedures and early supportive measures to help prevent further injury. For patients with injury to bone and/or ligaments, the initial focus should be spinal immobilization and prevention of inducing injury to the spinal cord. Spinal cord injury is associated with numerous life-threatening complications during the acute and long-term phases of care that all acute care surgeons must recognize. Published by Elsevier Inc.

  17. Upper extremity golf injuries.

    Science.gov (United States)

    Cohn, Michael A; Lee, Steven K; Strauss, Eric J

    2013-01-01

    Golf is a global sport enjoyed by an estimated 60 million people around the world. Despite the common misconception that the risk of injury during the play of golf is minimal, golfers are subject to a myriad of potential pathologies. While the majority of injuries in golf are attributable to overuse, acute traumatic injuries can also occur. As the body's direct link to the golf club, the upper extremities are especially prone to injury. A thorough appreciation of the risk factors and patterns of injury will afford accurate diagnosis, treatment, and prevention of further injury.

  18. Spinal injury in sport

    International Nuclear Information System (INIS)

    Barile, Antonio; Limbucci, Nicola; Splendiani, Alessandra; Gallucci, Massimo; Masciocchi, Carlo

    2007-01-01

    Spinal injuries are very common among professional or amateur athletes. Spinal sport lesions can be classified in overuse and acute injuries. Overuse injuries can be found after years of repetitive spinal load during sport activity; however specific overuse injuries can also be found in adolescents. Acute traumas are common in contact sports. Most of the acute injuries are minor and self-healing, but severe and catastrophic events are possible. The aim of this article is to review the wide spectrum of spinal injuries related to sport activity, with special regard to imaging finding

  19. Urological injuries following trauma.

    Science.gov (United States)

    Bent, C; Iyngkaran, T; Power, N; Matson, M; Hajdinjak, T; Buchholz, N; Fotheringham, T

    2008-12-01

    Blunt renal trauma is the third most common injury in abdominal trauma following splenic and hepatic injuries, respectively. In the majority, such injuries are associated with other abdominal organ injuries. As urological injuries are not usually life-threatening, and clinical signs and symptoms are non-specific, diagnosis is often delayed. We present a practical approach to the diagnosis and management of these injuries based on our experience in a busy inner city trauma hospital with a review of the current evidence-based practice. Diagnostic imaging signs are illustrated.

  20. Feedback attribution of the land-sea warming contrast in a global warming simulation of the NCAR CCSM4

    International Nuclear Information System (INIS)

    Sejas, Sergio A; Albert, Oriene S; Cai, Ming; Deng, Yi

    2014-01-01

    One of the salient features in both observations and climate simulations is a stronger land warming than sea. This paper provides a quantitative understanding of the main processes that contribute to the land-sea warming asymmetry in a global warming simulation of the NCAR CCSM4. The CO 2 forcing alone warms the surface nearly the same for both land and sea, suggesting that feedbacks are responsible for the warming contrast. Our analysis on one hand confirms that the principal contributor to the above-unity land-to-sea warming ratio is the evaporation feedback; on the other hand the results indicate that the sensible heat flux feedback has the largest land-sea warming difference that favors a greater ocean than land warming. Therefore, the results uniquely highlight the importance of other feedbacks in establishing the above-unity land-to-sea warming ratio. Particularly, the SW cloud feedback and the ocean heat storage in the transient response are key contributors to the greater warming over land than sea. (letter)

  1. Comparison of Distal Limb Warming With Fluidotherapy and Warm Water Immersion for Mild Hypothermia Rewarming.

    Science.gov (United States)

    Kumar, Parveen; McDonald, Gerren K; Chitkara, Radhika; Steinman, Alan M; Gardiner, Phillip F; Giesbrecht, Gordon G

    2015-09-01

    The purpose of the study was to determine the effectiveness of Fluidotherapy rewarming through the distal extremities for mildly hypothermic, vigorously shivering subjects. Fluidotherapy is a dry heat modality in which cellulose particles are suspended by warm air circulation. Seven subjects (2 female) were cooled on 3 occasions in 8˚C water for 60 minutes, or to a core temperature of 35°C. They were then dried and rewarmed in a seated position by 1) shivering only; 2) Fluidotherapy applied to the distal extremities (46 ± 1°C, mean ± SD); or 3) water immersion of the distal extremities (44 ± 1°C). The order of rewarming followed a balanced design. Esophageal temperature, skin temperature, heart rate, oxygen consumption, and heat flux were measured. The warm water produced the highest rewarming rate, 6.1°C·h(-1), 95% CI: 5.3-6.9, compared with Fluidotherapy, 2.2°C·h(-1), 95% CI: 1.4-3.0, and shivering only, 2.0°C·h(-1), 95% CI: 1.2-2.8. The Fluidotherapy and warm water conditions increased skin temperature and inhibited shivering heat production, thus reducing metabolic heat production (166 ± 42 W and 181 ± 45 W, respectively), compared with shivering only (322 ± 142 W). Warm water provided a significantly higher net heat gain (398.0 ± 52 W) than shivering only (288.4 ± 115 W). Fluidotherapy was not as effective as warm water for rewarming mildly hypothermic subjects. Although Fluidotherapy is more portable and technically simpler, it provides a lower rate of rewarming that is similar to shivering only. It does help decrease shivering heat production, lowering energy expenditure and cardiac work, and could be considered in a hospital setting, if convenient. Copyright © 2015 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.

  2. Consistency of the tachyon warm inflationary universe models

    International Nuclear Information System (INIS)

    Zhang, Xiao-Min; Zhu, Jian-Yang

    2014-01-01

    This study concerns the consistency of the tachyon warm inflationary models. A linear stability analysis is performed to find the slow-roll conditions, characterized by the potential slow-roll (PSR) parameters, for the existence of a tachyon warm inflationary attractor in the system. The PSR parameters in the tachyon warm inflationary models are redefined. Two cases, an exponential potential and an inverse power-law potential, are studied, when the dissipative coefficient Γ = Γ 0 and Γ = Γ(φ), respectively. A crucial condition is obtained for a tachyon warm inflationary model characterized by the Hubble slow-roll (HSR) parameter ε H , and the condition is extendable to some other inflationary models as well. A proper number of e-folds is obtained in both cases of the tachyon warm inflation, in contrast to existing works. It is also found that a constant dissipative coefficient (Γ = Γ 0 ) is usually not a suitable assumption for a warm inflationary model

  3. [Startup mechanism of moxibustion warming and dredging function].

    Science.gov (United States)

    Huang, Kaiyu; Liang, Shuang; Sun, Zheng; Zhang, Jianbin

    2017-09-12

    With "moxibustion" and "warm stimulation" as the keywords, the literature on moxibustion mechanism of warming and dredging from June 1st, 1995 to June 1st, 2016 was collected from PubMed, China National Knowledge Infrastructure (CNKI) and Wanfang database. The startup mechanism of moxibustion warming and dredging function was analyzed in terms of moxibustion warming stimulation. The results were found that moxibustion was based on local rising temperature of acupoint. It activated local specific receptors, heat sensitive immune cells, heat shock proteins and so on to start the warming and dredging function and produce various local effects. The warming stimulation signals as well as subsequent effects through nerve and body fluid pathways induced the effects of further specific target organs and body systems.

  4. Ocean acidification ameliorates harmful effects of warming in primary consumer.

    Science.gov (United States)

    Pedersen, Sindre Andre; Hanssen, Anja Elise

    2018-01-01

    Climate change-induced warming and ocean acidification are considered two imminent threats to marine biodiversity and current ecosystem structures. Here, we have for the first time examined an animal's response to a complete life cycle of exposure to co-occurring warming (+3°C) and ocean acidification (+1,600 μatm CO 2 ), using the key subarctic planktonic copepod, Calanus finmarchicus , as a model species. The animals were generally negatively affected by warming, which significantly reduced the females' energy status and reproductive parameters (respectively, 95% and 69%-87% vs. control). Unexpectedly, simultaneous acidification partially offset the negative effect of warming in an antagonistic manner, significantly improving reproductive parameters and hatching success (233%-340% improvement vs. single warming exposure). The results provide proof of concept that ocean acidification may partially offset negative effects caused by warming in some species. Possible explanations and ecological implications for the observed antagonistic effect are discussed.

  5. Comparison of oxidative/antioxidative status of penile corpus cavernosum blood and peripheral venous blood.

    Science.gov (United States)

    Yeni, E; Gulum, M; Selek, S; Erel, O; Unal, D; Verit, A; Savas, M

    2005-01-01

    The aim of the study is to determine and to compare the oxidative and antioxidative status of penile corpus cavernosum and peripheral venous blood. A total of 28 adult healthy males were included in the study. Whole blood was simultaneously withdrawn from penile corpus cavernosum and the cubital vein and their plasma separated. Total antioxidant capacity (TAC), vitamin C, total protein, albumin, uric acid, bilirubin and total peroxide (TP) levels of both plasma samples were measured and compared. While TAC, total protein, albumin, bilirubin and uric acid levels were higher, vitamin C levels were lower in cavernosal blood than that of peripheral blood. On the other hand, TP level was found to be higher in penile blood samples than that of peripheral blood. We thought that the normal erectile process of the penile cavernosal body leads to increased production of oxidants as in the mechanism of ischaemia-reperfusion; however, the increase of TAC can prevent development of oxidative injury.

  6. Effect of methylprednisolone on the oxidative burst activity, adhesion molecules and clinical outcome following open heart surgery

    DEFF Research Database (Denmark)

    Toft, P; Christiansen, K; Tønnesen, Else Kirstine

    1997-01-01

    Following cardiac surgery with cardiopulmonary bypass (CPB), activated granulocytes may be involved with ischaemia/ reperfusion injury. The purpose of this study was to investigate whether steroids could reduce the oxidative burst activity of granulocytes, the expression of adhesion molecules...... on granulocytes and improve clinical outcome. Sixteen patients undergoing open heart surgery participated in the study. Eight were randomized to receive methylprednisolone (30 mg/kg intravenously) at the start of anaesthesia while eight patients served as a control group. The oxidative burst was measured flow...... not improve the weaning from the ventilator or reduce the stay in the intensive-care unit. In conclusion, treatment with steroids prevented hyperthermia following open heart surgery with CPB and reduced capillary leak during ECC. Methylprednisolone, however, did not reduce the oxidative burst activity...

  7. Impact of Global Warming on Flora and Fauna

    OpenAIRE

    , A. Srivastava; , S. Srivastav

    2011-01-01

    The paper, illustrated with graphs, discusses the impact of global warming on şora & fauna, its underlying causes, and attempts to trim down it with the collaboration of all individuals. The paper relates that, as an outcome of global warming, climate changes have reached anomalous levels with rainfall and hurricanes of unusual intensity. Everyday gases such as carbon dioxide are released to warm the earth, allowing it to be a place that can be inhabited by şora & fauna. Howev...

  8. Human-caused Indo-Pacific warm pool expansion

    OpenAIRE

    Weller, Evan; Min, Seung-Ki; Cai, Wenju; Zwiers, Francis W.; Kim, Yeon-Hee; Lee, Donghyun

    2016-01-01

    The Indo-Pacific warm pool (IPWP) has warmed and grown substantially during the past century. The IPWP is Earth?s largest region of warm sea surface temperatures (SSTs), has the highest rainfall, and is fundamental to global atmospheric circulation and hydrological cycle. The region has also experienced the world?s highest rates of sea-level rise in recent decades, indicating large increases in ocean heat content and leading to substantial impacts on small island states in the region. Previou...

  9. The epidemiology, evaluation, and management of stingray injuries.

    Science.gov (United States)

    Diaz, James H

    2007-01-01

    A descriptive analysis and review of the world's salient scientific literature on stingray injuries was conducted in light of recent high-profile cases of fatal and near-fatal thoracic stingray injuries to guide clinicians in evaluating and managing stingray injuries. Data was extracted from observational and longitudinal studies over the period, 1950-2006, to permit (1) a stratification of stingray injuries as bites, penetrating lacerations with and without envenoming, and combinations of deeply penetrating and envenoming wounds; and (2) an assessment of new management strategies for thoracoabdominal penetrating trauma and non-healing, necrotic stingray wounds. Unlike their Chondrichthyes classmates, the sharks, stingrays are docile and non-aggressive; and will not attack with their spined tails, unless provoked. Although some occupations are predisposed to stingray injuries, most stingray injuries can be avoided by observing seafloors and adopting simple practices when wading, swimming, diving, or fishing in temperate oceans and some tropical freshwater river systems. All stingray injuries should be managed initially with wound irrigation to dislodge retained spine fragments and envenoming tissues and warm water immersion to inactivate heat-labile toxins.

  10. Epidemiology of golf related musculo-skeletal injuries

    Directory of Open Access Journals (Sweden)

    Dhillon Mandeep

    2006-01-01

    Full Text Available Background : Golfing has become an increasingly popular sport enjoyed by both men and women. Although the game is not viewed as hazardous, golfers do sustain injuries connected with the game. However, golf injuries have received little attention in the literature and there is no study from Asia. Methods : A prospective study was undertaken to analyze the incidence, cause and type of injury among amateur golfers. Open ended questionnaires were sent to 1000 golfers; 240 responded (Av age 51 years, 200 males and 40 females. The respondents played an average of 2 rounds per week. Results : One hundered and ten (46% responders had sustained one or more orthopaedic injuries. Both among men and women, the lower back was the most common site of injury followed by shoulder and dorsal spine. There was a difference in the injury pattern in skilled and relatively unskilled players. Lack of warm up, excessive practice and improper swing mechanics were the most common causes. Conclusion : Golf injuries perhaps could be prevented or reduced by proper technique, controlled practice routines, physical conditioning and pre-play stretching exercises. The most important factor in this playing population seems to be prevention.

  11. Key Injury and Violence Data

    Science.gov (United States)

    ... Traumatic Brain Injury Violence Prevention Key Injury and Violence Data Recommend on Facebook Tweet Share Compartir Injuries ... of death among persons 1-44. Injury- and violence-related deaths are only part of the problem ...

  12. Global warming and neurodegenerative disorders: speculations on their linkage

    Science.gov (United States)

    Habibi, Laleh; Perry, George; Mahmoudi, Morteza

    2014-01-01

    Climate change is having considerable impact on biological systems. Eras of ice ages and warming shaped the contemporary earth and origin of creatures including humans. Warming forces stress conditions on cells. Therefore, cells evolved elaborate defense mechanisms, such as creation of heat shock proteins, to combat heat stress. Global warming is becoming a crisis and this process would yield an undefined increasing rate of neurodegenerative disorders in future decades. Since heat stress is known to have a degenerative effects on neurons and, conversely, cold conditions have protective effect on these cells, we hypothesize that persistent heat stress forced by global warming might play a crucial role in increasing neurodegenerative disorders. PMID:25671171

  13. The Basketball warms-ups - theoretical assumptions and practical solutions

    OpenAIRE

    Sebastian Łubiński; Jan Kosendiak

    2017-01-01

    Many authors emphasize the importance of warm-up. Warm-up in team games aims at enhancing the body adaptation to the physical activity and to activate physiological functions from the rest state to the active state. Warm-up brings many different benefits, for example: physiological, psychological, and preventive, regardless of the classification of the above. From a psychological standpoint, the warm-up is performed to create the body "alertness", activity and readiness, and a willingness to ...

  14. Global warming and neurodegenerative disorders: speculations on their linkage.

    Science.gov (United States)

    Habibi, Laleh; Perry, George; Mahmoudi, Morteza

    2014-01-01

    Climate change is having considerable impact on biological systems. Eras of ice ages and warming shaped the contemporary earth and origin of creatures including humans. Warming forces stress conditions on cells. Therefore, cells evolved elaborate defense mechanisms, such as creation of heat shock proteins, to combat heat stress. Global warming is becoming a crisis and this process would yield an undefined increasing rate of neurodegenerative disorders in future decades. Since heat stress is known to have a degenerative effects on neurons and, conversely, cold conditions have protective effect on these cells, we hypothesize that persistent heat stress forced by global warming might play a crucial role in increasing neurodegenerative disorders.

  15. Understanding the challenges of global warming

    International Nuclear Information System (INIS)

    Smith, P.

    2003-01-01

    The evolution of the threat of global warming and the chronology of the last half century of efforts to prevent it from overwhelming humanity is chronicled. It was in the 1970s when it was first realized that the cumulative total of atmospheric carbon dioxide from fossil fuel burning had been steadily rising from the pre-industrial 280 ppmv (parts per million by volume) to 325 ppmv, approximately parallel with the rise of industrialization. Nevertheless, the first attempt at a global accord to reduce emissions was not made until 1992, when the Rio de Janeiro Earth Summit tried, but miserably failed to reach agreement, having been prevented from achieving anything of substance by a loose-knit group of nations and commercial interests. Binding agreements were finally reached at the next scheduled international meeting in Kyoto, Japan, in 1997. There is a detailed discussion of the Kyoto Protocols, the measures that Annex One nations such as Canada have to do to achieve the six per cent reductions targets below 1990 levels of emissions by 2010, and estimates of the costs involved. These discussions of proposed actions are balanced by a display of examples of the the growing volume of arguments advanced by opponents who not only disagree about what can be done to reduce emissions, but that there is anything that needs to be done at all. Central to their arguments is the denial that human activities are responsible for global warming, disregarding the overwhelming evidence by 3000+ leading scientists of the Intergovernmental Panel on Climate Change that most of the global warming over the last 50 years is attributable to human activities. The rest of the article details what can and needs to be done to reverse the cumulative impact of greenhouse gas emissions, how we can produce the energy we need at the lowest environmental cost, and the types of energy (solar, wind, biomass, natural gas) that result in the smallest GHG emissions. Familiar arguments are recited to

  16. Head injury - first aid

    Science.gov (United States)

    ... medlineplus.gov/ency/article/000028.htm Head injury - first aid To use the sharing features on this page, ... a concussion can range from mild to severe. First Aid Learning to recognize a serious head injury and ...

  17. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... of Spinal Cord Injury Rehabilitation Kristine Cichowski, MS Occupational Therapy after Spinal Cord Injury Katie Powell, OT ... does not provide medical advice, recommend or endorse health care products or services, or control the information ...

  18. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... How Peer Counseling Works Julie Gassaway, MS, RN Pediatric Injuries Pediatric Spinal Cord Injury 101 Lawrence Vogel, MD The Basics of Pediatric SCI Rehabilitation Sara Klaas, MSW Transitions for Children ...

  19. Elbow Injuries and Disorders

    Science.gov (United States)

    ... Many things can make your elbow hurt. A common cause is tendinitis, an inflammation or injury to the tendons that attach muscle to bone. Tendinitis of the elbow is a sports injury, often from playing tennis or golf. You ...

  20. Posterior Cruciate Ligament Injury

    Science.gov (United States)

    ... your knee is bent also can cause this injury. Risk factors Being in a motor vehicle accident and participating in sports such as football and soccer are the most common risk factors for a PCL injury. Complications In ...

  1. Brain injury - discharge

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000163.htm Brain injury - discharge To use the sharing features on ... know was in the hospital for a serious brain injury. At home, it will take time for ...

  2. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... of spinal cord injuries? play_arrow What does stem-cell research on animals tell us? play_arrow When can we expect stem-cell treatments to become available for spinal cord injuries? ...

  3. Football injuries: current concepts.

    Science.gov (United States)

    Olson, David E; Sikka, Robby Singh; Hamilton, Abigail; Krohn, Austin

    2011-01-01

    Football is one of the most popular sports in the United States and is the leading cause of sports-related injury. A large focus in recent years has been on concussions, sudden cardiac death, and heat illness, all thought to be largely preventable health issues in the young athlete. Injury prevention through better understanding of injury mechanisms, education, proper equipment, and practice techniques and preseason screening may aid in reducing the number of injuries. Proper management of on-field injuries and health emergencies can reduce the morbidity associated with these injuries and may lead to faster return to play and reduced risk of future injury. This article reviews current concepts surrounding frequently seen football-related injuries.

  4. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... spinal cord injuries? play_arrow What does stem-cell research on animals tell us? play_arrow When can we expect stem-cell treatments to become available for spinal cord injuries? ...

  5. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Anne Bryden, OT The Role of the Social Worker after Spinal Cord Injury Patti Rogers, SW Marguerite ... arrow Why are high-dose steroids often used right after an injury? play_arrow What is meant ...

  6. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Spinal Cord Injuries Video Library SCI Medical Experts People Living with SCI Personal Experiences by Topic Resources ... Spinal Cord Injuries Video Library SCI Medical Experts People Living with SCI Personal Experiences by Topic Resources ...

  7. Mountain Biking Injuries.

    Science.gov (United States)

    Ansari, Majid; Nourian, Ruhollah; Khodaee, Morteza

    With the increasing popularity of mountain biking, also known as off-road cycling, and the riders pushing the sport into extremes, there has been a corresponding increase in injury. Almost two thirds of acute injuries involve the upper extremities, and a similar proportion of overuse injuries affect the lower extremities. Mountain biking appears to be a high-risk sport for severe spine injuries. New trends of injury patterns are observed with popularity of mountain bike trail parks and freeride cycling. Using protective gear, improving technical proficiency, and physical fitness may somewhat decrease the risk of injuries. Simple modifications in bicycle-rider interface areas and with the bicycle (bike fit) also may decrease some overuse injuries. Bike fit provides the clinician with postural correction during the sport. In this review, we also discuss the importance of race-day management strategies and monitoring the injury trends.

  8. Eye Injuries at Work

    Science.gov (United States)

    ... National Standards Institute (ANSI) to meet their eye protection standards. If an eye injury occurs, see an ophthalmologist or go to the emergency room immediately, even if the eye injury appears minor. Delaying medical attention can result in permanent vision ...

  9. Injury & Safety Report - Legacy

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Injury & Safety Report is a mandatory post trip legal document observers fill out to report any injuries they have incurred, illnesses they have had, or...

  10. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Injury Diane M. Rowles, MS, NP How Family Life Changes After Spinal Cord Injury Nancy Rosenberg, PsyD ... Rehabilitation Donald Peck Leslie, MD Adjusting to Social Life in a Wheelchair Lisa Rosen, MS Spasticity, Physical ...

  11. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Medical Experts People Living with SCI Personal Experiences by Topic Resources Peer ... Injuries Spinal Cord Injury 101 David Chen, MD Preventing Pressure Sores Mary Zeigler, MS Transition from Hospital to ...

  12. Skateboarding injuries of today

    OpenAIRE

    Forsman, L; Eriksson, A

    2001-01-01

    Background—Skateboarding injuries have increased with the rise in popularity of the sport, and the injury pattern can be expected to have changed with the development of both skateboard tricks and the materials used for skateboard construction.

  13. Traumatic Brain Injury

    Science.gov (United States)

    ... brain injury Some traumatic brain injuries have lasting effects, and some do not. You may be left with disabilities. These can be physical, behavioral, communicative, and/or mental. Customized treatment helps you to have as full ...

  14. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Living with SCI Personal Experiences by Topic Resources Peer ... Adult Injuries Spinal Cord Injury 101 David Chen, MD Preventing Pressure Sores Mary Zeigler, MS Transition from Hospital to ...

  15. Softball Pitching and Injury.

    Science.gov (United States)

    Lear, Aaron; Patel, Niraj

    2016-01-01

    The windmill softball pitch generates considerable forces about the athlete's shoulder and elbow. The injury pattern of softball pitchers seems to be primarily overuse injury, and they seem not to suffer the same volume of injury that baseball pitchers do. This article will explore softball pitching techniques, kinetics and kinematics of the windmill pitch, epidemiology of softball pitchers, and discuss possible etiologies of softball pitching injuries.

  16. Climate changes instead of global warming

    Directory of Open Access Journals (Sweden)

    Radovanović Milan M.

    2014-01-01

    Full Text Available Air temperature changes on Earth in recent years are the subject of numerous and increasingly interdisciplinary research. In contrast to, conditionally speaking, generally accepted views that these changes are conditioned primarily by anthropogenic activity, more results appear to suggest that it is dominant natural processes about. Whether because of the proven existence of areas in which downtrends are registered or the stagnation of air temperature, as opposed to areas where the increase is determined, in scientific papers, as well as the media, the increasingly present is the use of the term climate changes instead of the global warming. In this paper, we shall try to present arguments for the debate relating to the official view of the IPCC, as well as research indicating the opposite view.

  17. Global Warming and the Microwave Background

    Directory of Open Access Journals (Sweden)

    Robitaille P.-M.

    2009-04-01

    Full Text Available In the work, the importance of assigning the microwave background to the Earth is ad- dressed while emphasizing the consequences for global climate change. Climate mod- els can only produce meaningful forecasts when they consider the real magnitude of all radiative processes. The oceans and continents both contribute to terrestrial emis- sions. However, the extent of oceanic radiation, particularly in the microwave region, raises concerns. This is not only since the globe is covered with water, but because the oceans themselves are likely to be weaker emitters than currently believed. Should the microwave background truly be generated by the oceans of the Earth, our planet would be a much less efficient emitter of radiation in this region of the electromagnetic spectrum. Furthermore, the oceans would appear unable to increase their emissions in the microwave in response to temperature elevation, as predicted by Stefan’s law. The results are significant relative to the modeling of global warming.

  18. Frontiers and challenges in warm dense matter

    CERN Document Server

    Desjarlais, Michael; Redmer, Ronald; Trickey, Samuel

    2014-01-01

    Warm Dense Matter (WDM) occupies a loosely defined region of phase space intermediate between solid, liquid, gas, and plasma, and typically shares characteristics of two or more of these phases. WDM is generally associated with the combination of strongly coupled ions and moderately degenerate electrons, and careful attention to quantum physics and electronic structure is essential. The lack of a small perturbation parameter greatly limits approximate attempts at its accurate description. Since WDM resides at the intersection of solid state and high energy density physics, many high energy density physics (HEDP) experiments pass through this difficult region of phase space. Thus, understanding and modeling WDM is key to the success of experiments on diverse facilities. These include the National Ignition Campaign centered on the National Ignition Facility (NIF), pulsed-power driven experiments on the Z machine, ion-beam-driven WDM experiments on the NDCX-II, and fundamental WDM research at the Linear Coherent...

  19. Slow coolant phaseout could worsen warming

    Science.gov (United States)

    Reese, April

    2018-03-01

    In the summer of 2016, temperatures in Phalodi, an old caravan town on a dry plain in northwestern India, reached a blistering 51°C—a record high during a heat wave that claimed more than 1600 lives across the country. Wider access to air conditioning (AC) could have prevented many deaths—but only 8% of India's 249 million households have AC. As the nation's economy booms, that figure could rise to 50% by 2050. And that presents a dilemma: As India expands access to a life-saving technology, it must comply with international mandates—the most recent imposed just last fall—to eliminate coolants that harm stratospheric ozone or warm the atmosphere.

  20. Decarbonization and sequestration for mitigating global warming

    International Nuclear Information System (INIS)

    Steinberg, M.

    2000-01-01

    Mitigating the global warming greenhouse effect while maintaining a fossil fuel economy, requires improving efficiency of utilization of fossil fuels, use of high hydrogen content fossil fuels, decarbonization of fossil fuels, and sequestering of carbon and CO 2 applied to all the sectors of the economy, electric power generation, transportation, and industrial, and domestic power and heat generation. Decarbonization means removal of carbon as C or CO 2 either before or after fossil fuel combustion and sequestration means disposal of the recovered C or CO 2 including its utilization. Removal and recovery of CO 2 from power generation plants and sequestration in the ocean represents one possibility of making a major impact on reducing CO 2 emissions to the atmosphere. This paper will briefly review the progress made in ocean disposal and present some alternative schemes. (author)

  1. American lay conceptions of global warming

    International Nuclear Information System (INIS)

    Kempton, W.

    1990-01-01

    Ethnographic interviews were conducted with Americans from all walks of life in order to understand how ordinary citizens conceptualize global climate change and make value judgments about it. Most informants had heard of the greenhouse effect, but they held fundamental misconceptions that were shared across individuals. Many of these misconceptions derive from the process of fitting a new concept, global warming, into four preexisting categories: stratospheric ozone depletion, plant photosynthesis, tropospheric pollution, and personally-experienced seasonal and geographic temperature variation. Informants readily accepted that human activities could change climate and weather patterns. Indeed, most reported they had already observed changes in weather patterns, some citing space shots or atomic bomb testing as causes. Few informants connected the greenhouse effect to energy or fuel consumption, although the connection was easily understood when explained by the interviewers

  2. Warm Dark Matter from keVins

    International Nuclear Information System (INIS)

    King, Stephen F.; Merle, Alexander

    2012-01-01

    We propose a simple model for Warm Dark Matter (WDM) in which two fermions are added to the Standard Model: (quasi-) stable ''keVins'' (keV inert fermions) which account for WDM and their unstable brothers, the ''GeVins'' (GeV inert fermions), both of which carry zero electric charge and zero lepton number, and are (approximately) ''inert'', in the sense that their only interactions are via suppressed couplings to the Z. We consider scenarios in which stable keVins are thermally produced and their abundance is subsequently diluted by entropy production from the decays of the heavier unstable GeVins. This mechanism could be implemented in a wide variety of models, including E 6 inspired supersymmetric models or models involving sterile neutrinos

  3. Warm pre-stressing, preliminary experiments

    International Nuclear Information System (INIS)

    Hedner, G.

    1984-09-01

    The beneficial effect of warm pre-stressing, WPS, on apparent fracture thoughness at low temperature is well established. Tests are usually performed with constant load during the cooling part of the load cycle. In practice load variations may occur during this part. The present paper reports a preliminary study of the influence of superimposed fatigue loads. It is found that if crack propagation occurs during cooling+fatigue loading, then the maximum load during the fatigue load cycle is the preload to be used for WPS consideration. A few tests were preformed to study the effect of preload reversal. Tensile preload was followed by a compressive load and after unloading the specimens were cooled and fractured. It was found that for the high preload level used in the tests, the beneficial effect of the tensile preload could be totally annihilated by the compressive preload. (author)

  4. Use of nuclear energy and land warming

    Energy Technology Data Exchange (ETDEWEB)

    Barbosa, Jose Alberto Maia; Sordi, Gian Maria Agostino Angelo; Frazao, Selma Violato; Zago, Franco Raphael do Carmo [Instituto de Pesquisas Energeticas e Nucleares (IPEN-CNEN/SP), Sao Paulo, SP (Brazil)], E-mail: blosspriester@gmail.com, E-mail: gmsordi@ipen.br, E-mail: selma.violato@terra.com.br, E-mail: fzago@ipen.br

    2007-07-01

    The world is facing an energy requirement that hardly will be covered by renewable sources actually researched. Though there is almost unanimity in the scientific community about the fact that nuclear energy is still a better option to replace oil and coal, environmental restrictions go on vigorous. And consequently, this non-consensus on nuclear energy benefits, greenhouse effect and weakening of ozone layer go on causing the land warming. In Brazil, nuclear plants are competitive and are capable to produce energy in a safe way, thus contributing to the stabilization of the national electric system and to the expansion of installed capacity and as alternative source of energy and applications for peaceful purposes, preserving the environment and planet inhabitants. (author)

  5. Microwave sounding units and global warming

    Science.gov (United States)

    Gary, Bruce L.; Keihm, Stephen J.

    1991-01-01

    A recent work of Spencer and Christy (1990) on precise monitoring of global temperature trends from satellites is critically examined. It is tentatively concluded in the present comment that remote sensing using satellite microwave radiometers can in fact provide a means for the monitoring of troposphere-averaged air temperature. However, for this to be successful more than one decade of data will be required to overcome the apparent inherent variability of global average air temperature. It is argued that the data set reported by Spencer and Christy should be subjected to careful review before it is interpreted as evidence of the presence or absence of global warming. In a reply, Christy provides specific responses to the commenters' objections.

  6. Natural gas industry and global warming

    International Nuclear Information System (INIS)

    Staropoli, R.; Darras, M.

    1997-01-01

    Natural gas has a very good potential compared to other fossil fuels as regard to global warming because of its high content of hydrogen, and its versatility in uses. To take full advantage of this potential, further development of gas designed boilers and furnaces, gas catalytic combustion, fuel cells are needed, but progresses in the recent years have been very promising. The natural gas industry' environmental potential is discussed. Regarding methane emission, progresses have been done is Western Europe on the distribution network, and some improvement are underway. It is however important to rationalize the effort by acting on the most emitting subsystem: this can be achieved by cooperation along the whole gas chain. (R.P.)

  7. Ocean deoxygenation in a warming world.

    Science.gov (United States)

    Keeling, Ralph E; Körtzinger, Arne; Gruber, Nicolas

    2010-01-01

    Ocean warming and increased stratification of the upper ocean caused by global climate change will likely lead to declines in dissolved O2 in the ocean interior (ocean deoxygenation) with implications for ocean productivity, nutrient cycling, carbon cycling, and marine habitat. Ocean models predict declines of 1 to 7% in the global ocean O2 inventory over the next century, with declines continuing for a thousand years or more into the future. An important consequence may be an expansion in the area and volume of so-called oxygen minimum zones, where O2 levels are too low to support many macrofauna and profound changes in biogeochemical cycling occur. Significant deoxygenation has occurred over the past 50 years in the North Pacific and tropical oceans, suggesting larger changes are looming. The potential for larger O2 declines in the future suggests the need for an improved observing system for tracking ocean 02 changes.

  8. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... the spinal cord work? play_arrow Why is the level of a spinal cord injury important? play_arrow What role does “compression” play in a spinal cord injury? play_arrow Why are high-dose steroids often used right after an injury? play_arrow What is meant ...

  9. HAND INJURIES IN VOLLEYBALL

    NARCIS (Netherlands)

    BHAIRO, NH; NIJSTEN, MWN; VANDALEN, KC; TENDUIS, HJ

    We studied the long-term sequelae of hand injuries as a result of playing volleyball. In a retrospective study, 226 patients with injuries of the hand who were seen over a 5-year period at our Trauma Department, were investigated. Females accounted for 66 % of all injuries. The mean age was 26

  10. Lightning injury: a review.

    Science.gov (United States)

    Ritenour, Amber E; Morton, Melinda J; McManus, John G; Barillo, David J; Cancio, Leopoldo C

    2008-08-01

    Lightning is an uncommon but potentially devastating cause of injury in patients presenting to burn centers. These injuries feature unusual symptoms, high mortality, and significant long-term morbidity. This paper will review the epidemiology, physics, clinical presentation, management principles, and prevention of lightning injuries.

  11. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Cord Injury Allen Heinemann, PhD How Peer Counseling Works Julie Gassaway, MS, RN Pediatric Injuries Pediatric Spinal ... injury? play_arrow How does the spinal cord work? play_arrow Why is the level of a ...

  12. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... arrow What is the “Spinal Cord Injury Model Systems” program? play_arrow What are the most promising new treatments for spinal cord injuries? play_arrow What are the latest developments in the use of electrical stimulation for spinal cord injuries? play_arrow ...

  13. Injury prevention in football

    African Journals Online (AJOL)

    other sports,[1,2] and youth football players are no exception to this. ... at risk of sports injury because of high levels of exposure at a time of major physiological change.[4] The ..... As part of injury prevention, adequate injury management and.

  14. Spinal Cord Injuries

    Science.gov (United States)

    ... forth between your body and your brain. A spinal cord injury disrupts the signals. Spinal cord injuries usually begin with a blow that fractures or ... down on the nerve parts that carry signals. Spinal cord injuries can be complete or incomplete. With a complete ...

  15. Rotator Cuff Injuries.

    Science.gov (United States)

    Connors, G. Patrick

    Many baseball players suffer from shoulder injuries related to the rotator cuff muscles. These injuries may be classified as muscular strain, tendonitis or tenosynovitis, and impingement syndrome. Treatment varies from simple rest to surgery, so it is important to be seen by a physician as soon as possible. In order to prevent these injuries, the…

  16. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Spinal Cord Injury Guy W. Fried, MD Substance Abuse and Spinal Cord Injury Allen Heinemann, PhD How ... arrow Why are high-dose steroids often used right after an injury? play_arrow What is meant ...

  17. Knee injuries in football

    African Journals Online (AJOL)

    swimming and basketball.1 In 2001 it was reported to have injury rates of 1 000 times ... knee injury in football are the age of the player, a previous injury and the ligamentous .... football is possible, although the success rates may vary from ...

  18. Groin injuries in atheletes

    DEFF Research Database (Denmark)

    Hölmich, Per

    2017-01-01

    Groin injuries have a bad reputation as very difficult to diagnose and treat. However, this is not justified and in the last two decades an increasing number of good scientific papers have been published. The key to the groin injuries is the anatomy. Groin injuries are related to muscles, tendons...

  19. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... Abuse and Spinal Cord Injury Allen Heinemann, PhD How Peer Counseling Works Julie Gassaway, MS, RN Pediatric Injuries Pediatric Spinal ... What is a spinal cord injury? play_arrow How does the spinal cord work? play_arrow Why is the level of a ...

  20. Assessment of Ankle Injuries

    Science.gov (United States)

    Mai, Nicholas; Cooper, Leslie

    2009-01-01

    School nurses are faced with the challenge of identifying and treating ankle injuries in the school setting. There is little information guiding the assessment and treatment of these children when an injury occurs. It is essential for school nurses to understand ankle anatomy, pathophysiology of the acute ankle injury, general and orthopedic…

  1. [Acute kidney injury

    NARCIS (Netherlands)

    Hageman, D.; Kooman, J.P.; Lance, M.D.; van Heurn, L.W.; Snoeijs, M.G.

    2012-01-01

    - 'Acute kidney injury' is modern terminology for a sudden decline in kidney function, and is defined by the RIFLE classification (RIFLE is an acronym for Risk, Injury, Failure, Loss and End-stage kidney disease).- Acute kidney injury occurs as a result of the combination of reduced perfusion in the

  2. Effects of back warming in cocoon stars

    International Nuclear Information System (INIS)

    Donnison, J.R.; Williams, I.P.

    1976-01-01

    It is stated that dust shells frequently surround young stars, and attempts have been made to determine some of the properties of these shells. It is probable that the dust absorbs the outgoing radiation from the star and re-emits it in the infrared. If the dust shell does absorb radiation both its inner and outer surfaces will re-emit a certain proportion and some radiation will return to the central star, causing what amounts to 'warming of its own back'. It is interesting to consider how such a star evolves, compared with evolution of a normal pre-main-sequence star. A model for a contracting star that is receiving radiation from an external source has been developed by the authors in connection with the evolution of Jupiter within the radiation field of the Sun (Astrophys. Space Sci., 29:387 (1974)), and this model is here applied to the situation just described. It is emphasised that the discussion is concerned only with the evolution of the central star, the dust being regarded merely as a means of redirecting radiation back on to the surface of this star. Amongst conclusions reached is that a thin shell will cause no significant change in the structure and evolution of the central star, whilst the presence of a thick shell has a substantial effect on the star, slowing down is evolution. Whilst a dust shell is present the star cannot be seen, but only the dust shell emitting in the infrared, but once the dust shell clears the star is seen in a position and with an age that differs considerably from what it would have had if it had evolved without 'back warming' from the dust shell. (U.K.)

  3. Competitive advantage on a warming planet.

    Science.gov (United States)

    Lash, Jonathan; Wellington, Fred

    2007-03-01

    Whether you're in a traditional smokestack industry or a "clean" business like investment banking, your company will increasingly feel the effects of climate change. Even people skeptical about global warming's dangers are recognizing that, simply because so many others are concerned, the phenomenon has wide-ranging implications. Investors already are discounting share prices of companies poorly positioned to compete in a warming world. Many businesses face higher raw material and energy costs as more and more governments enact policies placing a cost on emissions. Consumers are taking into account a company's environmental record when making purchasing decisions. There's also a burgeoning market in greenhouse gas emission allowances (the carbon market), with annual trading in these assets valued at tens of billions of dollars. Companies that manage and mitigate their exposure to the risks associated with climate change while seeking new opportunities for profit will generate a competitive advantage over rivals in a carbon-constrained future. This article offers a systematic approach to mapping and responding to climate change risks. According to Jonathan Lash and Fred Wellington of the World Resources Institute, an environmental think tank, the risks can be divided into six categories: regulatory (policies such as new emissions standards), products and technology (the development and marketing of climate-friendly products and services), litigation (lawsuits alleging environmental harm), reputational (how a company's environmental policies affect its brand), supply chain (potentially higher raw material and energy costs), and physical (such as an increase in the incidence of hurricanes). The authors propose a four-step process for responding to climate change risk: Quantify your company's carbon footprint; identify the risks and opportunities you face; adapt your business in response; and do it better than your competitors.

  4. Are Claims of Global Warming Being Suppressed?

    Science.gov (United States)

    Crowley, Thomas J.

    2006-02-01

    Over the last few years, I have heard many rumors that climate science relevant to the global warming discussion is being suppressed by the Bush Administration. One cannot do much about third-hand information. However, on 29 January, the New York Times published a front page article on NASA efforts to suppress statements about global warming by James Hansen, director of the NASA Goddard Institute for Space Studies. A claim by one government scientist, though, no matter how distinguished, still requires examples from other scientists before a general conclusion can be drawn about the overall scope of the problem. But if the charges are more widespread, then some government scientists might be reluctant to make such claims, because they might feel that their positions were jeopardized. Therefore, an alternate way may be needed to determine the scope of the issue, while still safeguarding government workers from possible retaliation. -On 30 January, Rep. Sherwood Boehlert (R-N.Y.), chairman of the U.S. House of Representatives Committee on Science, wrote a letter to NASA Administrator Michael Griffin addressing many of the concerns Crowley has raised. Boehlert wrote,``It ought to go without saying that government scientists must be free to describe their scientific conclusions and the implications of those conclusions to their fellow scientists, policymakers and the general public.'' He continued,``Good science cannot long persist in an atmosphere of intimidation. Political figures ought to be reviewing their public statements to make sure they are consistent with the best available science; scientists should not be reviewing their statements to make sure they are consistent with the current political orthodoxy.'' I commend Rep. Boehlert for his quick and clear statement of the importance of unfettered communication of science. -FRED SPILHAUS, Editor

  5. Global warming - Time to get things done

    International Nuclear Information System (INIS)

    Cognasse, Olivier; Dumas, Arnaud; Dupin, Ludovic; Moragues, Manuel; Rouaud, Pierre-Olivier

    2016-01-01

    A set of articles is proposed just before the COP22 in Morocco. A first article comments the content of the Paris agreement signed at the end of the COP21, evokes some commitments adopted by various countries to play a role in the struggle against global warming, mentions the various institutional steps before the COP22 in Marrakech, and evokes the commitment of the private sector. A second article highlights that actors of the finance sector trend to take the climate risk always more into account in their investments: this can be noticed with the development of green bonds. Then, in an interview, Nicolas Hulot comments the challenges and stakes of the COP22, outlines that everything is still to be done regarding the struggle against global warming and the decrease of the use of fossil energies, comments political and social consequences, criticizes the behaviour and approach of industries, notably Monsanto, and concludes by the need of a new tax policy. The next article discusses the recent evolutions of energy mixes in different countries and at the World level: slow decrease of carbon share, issue of the importance of nuclear energy, impact of carbon price, development of wind and solar energy everywhere. The other articles concern Morocco. An article then comments the Moroccan energy policy which is characterized by massive investments in green energies even if fossil energies are still prevailing. These developments are financed through a performing system based on public-private partnership. An article addresses the project of rehabilitation of a landfill by Suez in Meknes, and another one a Renault-Nissan factory, near Tangier, where water recycling is remarkable. The last article proposes a brief overview of the development of public and urban transport in Morocco: electric buses, tramways, project of a TGV line

  6. Injuries in synchronized skating.

    Science.gov (United States)

    Dubravcic-Simunjak, S; Kuipers, H; Moran, J; Simunjak, B; Pecina, M

    2006-06-01

    Synchronized skating is a relatively new competitive sport and data about injuries in this discipline are lacking. Therefore the purpose of this study was to investigate the frequency and pattern of acute and overuse injuries in synchronized skaters. Before and during the World Synchronized Skating Championship 2004, a questionnaire inquiring about the frequency of injuries in this skating discipline was given to 23 participating teams. A total of 514 women and 14 men senior skaters completed the questionnaires (100 % response). Two hundred and eighteen (42.4 %) female and 6 (42.9 %) male skaters had suffered from acute injuries during their synchronized skating career. As some skaters had suffered from more than one injury, the total number of acute injuries in females was 398 and in males 14. In female skaters 19.8 % of acute injuries were head injuries, 7.1 % trunk, 33.2 % upper, and 39.9 % lower extremity injuries. In male skaters 14.3 % were head injuries, 28.6 % upper, and 57.1 % lower extremity injuries, with no report of trunk injuries. Sixty-nine female and 2 male skaters had low back problems and 112 female and 2 male skaters had one or more overuse syndromes during their skating career. Of 155 overuse injuries in female skaters, 102 (65.8 %) occurred during their figure skating career, while 53 injuries (34.2 %) only occurred when they skated in synchronized skating teams. In male skaters, out of 5 overuse injuries, 4 (80 %) occurred in their figure skating career, while 1 (20 %) occurred during their synchronized skating career. Out of the total of 412 injuries, 338 (82 %) occurred during on-ice practice, while 74 (18 %) happened during off-ice training. Ninety-one (26.9 %) acute injures occurred while practicing individual elements, and 247 (73.1 %) on-ice injuries occurred while practicing different team elements. We conclude that injuries in synchronized skating should be of medical concern due to an increasing number of acute injuries, especially

  7. Change of ENSO characteristics in response to global warming

    Science.gov (United States)

    Sun, X.; Xia, Y.; Yan, Y.; Feng, W.; Huang, F.; Yang, X. Q.

    2017-12-01

    By using datasets of HadISST monthly SST from 1895 to 2014 and 600-year simulations of two CESM model experiments with/without doubling of CO2 concentration, ENSO characteristics are compared pre- and post- global warming. The main results are as follows. Due to global warming, the maximum climatological SST warming occurs in the tropical western Pacific (La Niña-like background warming) and the tropical eastern Pacific (El Niño-like background warming) for observations and model, respectively, resulting in opposite zonal SST gradient anomalies in the tropical Pacific. The La Niña-like background warming induces intense surface divergence in the tropical central Pacific, which enhances the easterly trade winds in the tropical central-western Pacific and shifts the strongest ocean-atmosphere coupling westward, correspondingly. On the contrary, the El Niño-like background warming causes westerly winds in the whole tropical Pacific and moves the strongest ocean-atmosphere coupling eastward. Under the La Niña-like background warming, ENSO tends to develop and mature in the tropical central Pacific, because the background easterly wind anomaly weakens the ENSO-induced westerly wind anomaly in the tropical western Pacific, leading to the so-called "Central Pacific ENSO (CP ENSO)". However, the so-called "Eastern Pacific ENSO (EP ENSO)" is likely formed due to increased westerly wind anomaly by the El Niño-like background warming. ENSO lifetime is significantly extended under both the El Niño-like and the La Niña-like background warmings, and especially, it can be prolonged by up to 3 months in the situation of El Niño-like background warming. The prolonged El Nino lifetime mainly applies to extreme El Niño events, which is caused by earlier outbreak of the westerly wind bursts, shallower climatological thermocline depth and weaker "discharge" rate of the ENSO warm signal in response to global warming. Results from both observations and the model also show that

  8. Comparing and contrasting Holocene and Eemian warm periods with greenhouse-gas-induced warming

    International Nuclear Information System (INIS)

    MacCracken, M.C.; Kutzbach, J.

    1990-01-01

    Periods of the past that are estimated to have been warmer than present are of great potential interest for comparison with simulations of future climates associated with greenhouse-gas-induced warming. Certain features of the climates of the mid-Holocene and Eemian periods, both interglacial maxima, are described. The simulated climatic responses to both types of forcing, in terms of land/ocean and latitudinal averages, are also compared. The zonal average and annual (or seasonal) average radiation fluxes associated with the different-from-present orbital conditions that existed for those interglacials are compared to the radiation flux associated with CO 2 -induced warming. There are some similarities but also significant differences in the two types of radiation flux perturbations, and there are both similarities and differences in the simulated climatic responses

  9. Costs of traffic injuries

    DEFF Research Database (Denmark)

    Kruse, Marie

    2015-01-01

    assessed using Danish national healthcare registers. Productivity costs were computed using duration analysis (Cox regression models). In a subanalysis, cost per severe traffic injury was computed for the 12 995 individuals that experienced a severe injury. RESULTS: The socioeconomic cost of a traffic...... injury was €1406 (2009 price level) in the first year, and €8950 over a 10-year period. Per 100 000 population, the 10-year cost was €6 565 668. A severe traffic injury costs €4969 per person in the first year, and €4 006 685 per 100 000 population over a 10-year period. Victims of traffic injuries...

  10. [Trauma registry and injury].

    Science.gov (United States)

    Shapira, S C

    2001-10-01

    The trauma registry network constitutes an essential database in every injury prevention system. In order to rationally estimate the extent of injury in general, and injuries from traffic accidents in particular, the trauma registry systems should contain the most comprehensive and broad database possible, in line with the operational definitions. Ideally, the base of the injury pyramid should also include mild injuries and even "near-misses". The Israeli National Trauma Registry has come a long way in the last few years. The eventual inclusion of all trauma centers in Israel will enable the establishment of a firm base for the allocation of resources by decision-makers.

  11. Triathlon: running injuries.

    Science.gov (United States)

    Spiker, Andrea M; Dixit, Sameer; Cosgarea, Andrew J

    2012-12-01

    The running portion of the triathlon represents the final leg of the competition and, by some reports, the most important part in determining a triathlete's overall success. Although most triathletes spend most of their training time on cycling, running injuries are the most common injuries encountered. Common causes of running injuries include overuse, lack of rest, and activities that aggravate biomechanical predisposers of specific injuries. We discuss the running-associated injuries in the hip, knee, lower leg, ankle, and foot of the triathlete, and the causes, presentation, evaluation, and treatment of each.

  12. [Trampoline injuries in children].

    Science.gov (United States)

    Sinikumpu, Juha-Jaakko; Antila, Eeva; Korhonen, Jussi; Rättyä, Johanna; Serlo, Willy

    2012-01-01

    Trampolines for home use have become common in Finland during the past ten years, being especially favored by children. Trampoline jumping is beneficial and constructive physical exercise, but poses a significant risk for injuries. The most common injuries include sprains and strains. During summertime, trampoline injuries account for as many as 13% of children's accidents requiring hospital care. Fractures are by far the most common trampoline injuries requiring hospital care. Injuries can be prevented by using safety nets. Only one child at a time is allowed to jump on the trampoline.

  13. Dismounted Complex Blast Injury.

    Science.gov (United States)

    Andersen, Romney C; Fleming, Mark; Forsberg, Jonathan A; Gordon, Wade T; Nanos, George P; Charlton, Michael T; Ficke, James R

    2012-01-01

    The severe Dismounted Complex Blast Injury (DCBI) is characterized by high-energy injuries to the bilateral lower extremities (usually proximal transfemoral amputations) and/or upper extremity (usually involving the non-dominant side), in addition to open pelvic injuries, genitourinary, and abdominal trauma. Initial resuscitation and multidisciplinary surgical management appear to be the keys to survival. Definitive treatment follows general principals of open wound management and includes decontamination through aggressive and frequent debridement, hemorrhage control, viable tissue preservation, and appropriate timing of wound closure. These devastating injuries are associated with paradoxically favorable survival rates, but associated injuries and higher amputation levels lead to more difficult reconstructive challenges.

  14. Continuously amplified warming in the Alaskan Arctic: Implications for estimating global warming hiatus

    Science.gov (United States)

    Wang, Kang; Zhang, Tingjun; Zhang, Xiangdong; Clow, Gary D.; Jafarov, Elchin E.; Overeem, Irina; Romanovsky, Vladimir; Peng, Xiaoqing; Cao, Bin

    2017-01-01

    Historically, in situ measurements have been notoriously sparse over the Arctic. As a consequence, the existing gridded data of surface air temperature (SAT) may have large biases in estimating the warming trend in this region. Using data from an expanded monitoring network with 31 stations in the Alaskan Arctic, we demonstrate that the SAT has increased by 2.19°C in this region, or at a rate of 0.23°C/decade during 1921–2015. Meanwhile, we found that the SAT warmed at 0.71°C/decade over 1998–2015, which is 2 to 3 times faster than the rate established from the gridded data sets. Focusing on the “hiatus” period 1998–2012 as identified by the Intergovernmental Panel on Climate Change (IPCC) report, the SAT has increased at 0.45°C/decade, which captures more than 90% of the regional trend for 1951–2012. We suggest that sparse in situ measurements are responsible for underestimation of the SAT change in the gridded data sets. It is likely that enhanced climate warming may also have happened in the other regions of the Arctic since the late 1990s but left undetected because of incomplete observational coverage.

  15. Design and performance of B4WarmED, an aboveground and belowground free-air warming experiment at the temperate-boreal forest ecotone

    Science.gov (United States)

    Conducting manipulative climate change experiments in forests is challenging, given their spatial heterogeneity and canopy complexity. One specific challenge involves warming both plants and soils to depth in ecosystems without much bare ground. We describe the design, implementation, and performanc...

  16. Aging, physical activity and sports injuries. An overview of common sports injuries in the elderly.

    Science.gov (United States)

    Kallinen, M; Markku, A

    1995-07-01

    -related injuries is prevention. Good agility, technical skills, and cardiovascular and musculoskeletal fitness are important in injury prevention among the elderly. Appropriate training programmes, the use of safe and familiar equipment, careful warming up and cooling down, multiphasic training [including the training of neurophysiological functions (balance, coordination and reaction time)] and muscle strength are essential aspects of injury prevention.

  17. Dynamical response of the Arctic winter stratosphere to global warming

    Science.gov (United States)

    Karpechko, A.; Manzini, E.

    2017-12-01

    Climate models often simulate dynamical warming of the Arctic stratosphere as a response to global warming in association with a strengthening of the deep branch of the Brewer-Dobson circulation; however until now, no satisfactory mechanism for such a response has been suggested. Here we investigate the role of stationary planetary waves in the dynamical response of the Arctic winter stratosphere circulation to global warming by analysing simulations performed with atmosphere-only Coupled Model Intercomparison Project Phase 5 (CMIP5) models driven by prescribed sea surface temperatures (SSTs). We focus on December-February (DJF) because this is the period when the troposphere and stratosphere are strongly coupled. When forced by increased SSTs, all the models analysed here simulate Arctic stratosphere dynamical warming, mostly due to increased upward propagation of quasi-stationary wave number 1, as diagnosed by the meridional eddy heat flux. By analysing intermodel spread in the response we show that the stratospheric warming and increased wave flux to the stratosphere correlate with the strengthening of the zonal winds in subtropics and mid-latitudes near the tropopause- a robust response to global warming. These results support previous studies of future Arctic stratosphere changes and suggest a dynamical warming of the Arctic wintertime polar vortex as the most likely response to global warming.

  18. The Relational Concurrence of Global Warming and Economic ...

    African Journals Online (AJOL)

    An attempt has been made to examine the concurrent relationship between global warming and economic development focusing on the danger it inheres in developing countries. To achieve this, the paper commenced with the conceptualization of global warming and economic development, the natural and human causes ...

  19. Conserving host–parasitoid interactions in a warming world

    NARCIS (Netherlands)

    Harvey, J.A.

    2015-01-01

    Anthropogenic global warming (AGW) represents a major threat to biodiversity at all levels of organization. Attendant changes with climate warming are abiotic effects such as changes in the duration and intensity of precipitation events, wind intensity and heat waves. Most importantly, AGW may

  20. Identifying the warm glow effect in contingent valuation

    NARCIS (Netherlands)

    Nunes, P.A.L.D.; Schokkaert, E.

    2003-01-01

    This paper reports the results from a contingent valuation study designed to investigate the influence of warm glow in willingness to pay (WTP) responses. Interindividual differences in warm glow motivation are measured through a factor analysis, performed on a list of attitudinal items. The