Sample records for warfare agents implications

  1. Biological warfare agents. (United States)

    Pohanka, Miroslav; Kuca, Kamil


    Biological warfare agents are a group of pathogens and toxins of biological origin that can be potentially misused for military or criminal purposes. The present review attempts to summarize necessary knowledge about biological warfare agents. The historical aspects, examples of applications of these agents such as anthrax letters, biological weapons impact, a summary of biological warfare agents and epidemiology of infections are described. The last section tries to estimate future trends in research on biological warfare agents.

  2. Biological warfare agents

    Directory of Open Access Journals (Sweden)

    Duraipandian Thavaselvam


    Full Text Available The recent bioterrorist attacks using anthrax spores have emphasized the need to detect and decontaminate critical facilities in the shortest possible time. There has been a remarkable progress in the detection, protection and decontamination of biological warfare agents as many instrumentation platforms and detection methodologies are developed and commissioned. Even then the threat of biological warfare agents and their use in bioterrorist attacks still remain a leading cause of global concern. Furthermore in the past decade there have been threats due to the emerging new diseases and also the re-emergence of old diseases and development of antimicrobial resistance and spread to new geographical regions. The preparedness against these agents need complete knowledge about the disease, better research and training facilities, diagnostic facilities and improved public health system. This review on the biological warfare agents will provide information on the biological warfare agents, their mode of transmission and spread and also the detection systems available to detect them. In addition the current information on the availability of commercially available and developing technologies against biological warfare agents has also been discussed. The risk that arise due to the use of these agents in warfare or bioterrorism related scenario can be mitigated with the availability of improved detection technologies.

  3. Biological Warfare Agents

    Directory of Open Access Journals (Sweden)

    Dev Vrat Kamboj


    Full Text Available There is a long historic record of use of biological warfare (BW agents by warring countriesagainst their enemies. However, the frequency of their use has increased since the beginningof the twentieth century. World war I witnessed the use of anthrax agent against human beingsand animals by Germans, followed by large-scale field trials by Japanese against war prisonersand Chinese population during world war II. Ironically, research and development in biologicalwarfare agents increased tremendously after the Geneva Protocol, signed in 1925, because ofits drawbacks which were overcome by Biological and Toxin Weapons Convention (BTWC in1972. Biological warfare programme took back seat after the 1972 convention but biologicalagents regained their importance after the bioterrorist attacks of anthrax powder in 2001. In thelight of these attacks, many of which turned out to be hoax, general awareness is required aboutbiological warfare agents that can be used against them. This review has been written highlightingimportant biological warfare agents, diseases caused by them, possible therapies and otherprotection measures.

  4. Toxicity of the Organophosphate Chemical Warfare Agents GA, GB, and VX: Implications for Public Protection.


    Munro, N


    The nerve agents, GA, GB, and VX are organophosphorus esters that form a major portion of the total agent volume contained in the U.S. stockpile of unitary chemical munitions. Congress has mandated the destruction of these agents, which is currently slated for completion in 2004. The acute, chronic, and delayed toxicity of these agents is reviewed in this analysis. The largely negative results from studies of genotoxicity, carcinogenicity, developmental, and reproductive toxicity are also pre...

  5. [Decontamination of chemical and biological warfare agents]. (United States)

    Seto, Yasuo


    Chemical and biological warfare agents (CBWA's) are diverse in nature; volatile acute low-molecular-weight toxic compounds, chemical warfare agents (CWA's, gaseous choking and blood agents, volatile nerve gases and blister agents, nonvolatile vomit agents and lacrymators), biological toxins (nonvolatile low-molecular-weight toxins, proteinous toxins) and microbes (bacteria, viruses, rickettsiae). In the consequence management against chemical and biological terrorism, speedy decontamination of victims, facilities and equipment is required for the minimization of the damage. In the present situation, washing victims and contaminated materials with large volumes of water is the basic way, and additionally hypochlorite salt solution is used for decomposition of CWA's. However, it still remains unsolved how to dispose large volumes of waste water, and the decontamination reagents have serious limitation of high toxicity, despoiling nature against the environments, long finishing time and non-durability in effective decontamination. Namely, the existing decontamination system is not effective, nonspecifically affecting the surrounding non-target materials. Therefore, it is the urgent matter to build up the usable decontamination system surpassing the present technologies. The symposiast presents the on-going joint project of research and development of the novel decontamination system against CBWA's, in the purpose of realizing nontoxic, fast, specific, effective and economical terrorism on-site decontamination. The projects consists of (1) establishment of the decontamination evaluation methods and verification of the existing technologies and adaptation of bacterial organophosphorus hydrolase, (2) development of adsorptive elimination technologies using molecular recognition tools, and (4) development of deactivation technologies using photocatalysis.

  6. Environmental chemistry of chemical warfare agents

    Energy Technology Data Exchange (ETDEWEB)

    MacNaughton, M.G.; Brewer, J.H.; Ledbetter-Ferrill, J. [Southwest Research Inst., San Antonio, TX (United States)


    This paper summarizes the approach used in the preparation of a Handbook for the Corps of Engineers, Huntsville Division, on the environmental chemistry of chemical warfare agents. The agents GB and HD will be used to illustrate the type of information in the report. Those readers interested in the full report should contact Mr. Arkie Fanning, Huntsville Corps of Engineers at (505) 955-5256. The U.S. Army Corps of Engineers (ACE) has identified approximately 7,200 formerly used defense sites (FUDS) in the United States, some of which are suspected to be contaminated with chemical warfare agents (CWA). The ACE has responsibility for environmental clean-up of FUDS, including site characterization, evaluation and remediation of the site. Thirty-four FUDS and 48 active DOD installations that may contain CWA were identified in an Interim Survey and Analysis Report by the USACMDA Program Manager for Non-Stockpile Chemical Material (NSCM). The chemical agents listed include sulfur mustard (H), lewisite (L), tabun (GA), sarin (GB), VX, hydrogen cyanide (AC), cyanogen chloride (CK), phosgene (CG), BZ, and CS.

  7. Chemical profiling of chemical warfare agents for forensic purposes

    NARCIS (Netherlands)

    Noort, D.; Reuver, L.P.J. de; Fidder, A.; Tromp, M.; Verschraagen, M.


    A program has been initiated towards the chemical profiling of chemical warfare agents, in order to support forensic investigations towards synthesis routes, production sites and suspect chemical suppliers. Within the first stage of the project various chemical warfare agents (VX, sulfur mustard, sa

  8. Chemical Warfare Agent Degradation and Decontamination

    Energy Technology Data Exchange (ETDEWEB)

    Talmage, Sylvia Smith [ORNL; Watson, Annetta Paule [ORNL; Hauschild, Veronique [U.S. Environmental Protection Agency; Munro, Nancy B [ORNL; King, J. [U.S. Army Environmental Center


    The decontamination of chemical warfare agents (CWA) from structures, environmental media, and even personnel has become an area of particular interest in recent years due to increased homeland security concerns. In addition to terrorist attacks, scenarios such as accidental releases of CWA from U.S. stockpile sites or from historic, buried munitions are also subjects for response planning. To facilitate rapid identification of practical and effective decontamination approaches, this paper reviews pathways of CWA degradation by natural means as well as those resulting from deliberately applied solutions and technologies; these pathways and technologies are compared and contrasted. We then review various technologies, both traditional and recent, with some emphasis on decontamination materials used for surfaces that are difficult to clean. Discussion is limited to the major threat CWA, namely sulfur mustard (HD, bis(2-chloroethyl)sulfide), VX (O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate), and the G-series nerve agents. The principal G-agents are GA (tabun, ethyl N,N-dimethylphosphoramidocyanidate), GB (sarin, isopropyl methylphosphonofluoridate), and GD (soman, pinacolyl methylphosphonofluoridate). The chemical decontamination pathways of each agent are outlined, with some discussion of intermediate and final degradation product toxicity. In all cases, and regardless of the CWA degradation pathway chosen for decontamination, it will be necessary to collect and analyze pertinent environmental samples during the treatment phase to confirm attainment of clearance levels.

  9. Handbook of toxicology of chemical warfare agents

    CERN Document Server


    This groundbreaking book covers every aspect of deadly toxic chemicals used as weapons of mass destruction and employed in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this one-of-a-kind handbook is prepared in a very user- friendly format that can easily be followed by students, teachers and researchers, as well as lay people. Stand-alone chapters on individual chemicals and major topics allow the reader to easily access required information without searching through the entire book. This is the first book that offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors, biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, prophylactic, therapeutic and countermeasures, and the role of homeland security. Presents a comprehensive look at all aspects of chemical warfare toxicology in one reference work. This saves research...

  10. Reactivity of Dual-Use Decontaminants with Chemical Warfare Agents (United States)


    decrease the logistical burden associated with transport and storage of decontaminants. The experiments in this study were focused on evaluating...propanediammonium dichloride, isopropanol, inert ingredients/water, hydrogen peroxide, diacetin Decontaminant formulated for chemical warfare agents F...potassium bisulfate, potassium sulfate, dipotassium peroxodisulfate, magnesium carbonate Acidic oxidative chemistry, used for VX laboratory waste

  11. Environmental assessments of sea dumped chemical warfare agents

    DEFF Research Database (Denmark)

    Sanderson, Hans; Fauser, Patrik

    This is a report on the information gathered during work related to sea dumped chemical warfare agents. It mainly reviews the work conducted in relation to the installation of the two Nord Stream gas pipeline from 2008-2012. The focus was on the weight-of-evidence risk assessment of disturbed CWA...

  12. Ultraviolet Raman scattering from persistent chemical warfare agents (United States)

    Kullander, Fredrik; Wästerby, Pär.; Landström, Lars


    Laser induced Raman scattering at excitation wavelengths in the middle ultraviolet was examined using a pulsed tunable laser based spectrometer system. Droplets of chemical warfare agents, with a volume of 2 μl, were placed on a silicon surface and irradiated with sequences of laser pulses. The Raman scattering from V-series nerve agents, Tabun (GA) and Mustard gas (HD) was studied with the aim of finding the optimum parameters and the requirements for a detection system. A particular emphasis was put on V-agents that have been previously shown to yield relatively weak Raman scattering in this excitation band.

  13. Hybrid Warfare: Implications for CAF Force Development (United States)


    also McCulloh and Johnson who demonstrate throughout their study that context is critical . Indeed, their summary statement for “hybrid warfare theory ...Muhr, eds., Hybrid and Cyber War as Consequences of the Asymmetry, Frankfurt : Peter Lang, 2011, p.95. Interestingly, the CFD Hybrid Warfare Concept...the highest political and military levels. The study of hybrid-type case studies yields the critical lesson that: “leadership is essential to victory

  14. Carbon Nanotubes: Detection of Chemical and Biological Warfare Agents

    Directory of Open Access Journals (Sweden)

    Om Kumar


    Full Text Available Discovery of carbon nanotubes has great impact on the development of newer methodologies and devicesuseful for the analysis of various types of chemicals. The functionalisation of CNTs with biomolecules relatedto chemical and biological warfare agents makes these useful for the detection of these agents. The detectionsensitivity can be increased manyfold. Various types of chemical and biological sensors were developed usingvarious type of carbon nanotubes as well as nano particles of different metals.Defence Science Journal, 2008, 58(5, pp.617-625, DOI:

  15. Metal organic frameworks for the catalytic detoxification of chemical warfare nerve agents

    Energy Technology Data Exchange (ETDEWEB)

    Hupp, Joseph T.; Farha, Omar K.; Katz, Michael J.; Mondloch, Joseph E.


    A method of using a metal organic framework (MOF) comprising a metal ion and an at least bidendate organic ligand to catalytically detoxify chemical warfare nerve agents including exposing the metal-organic-framework (MOF) to the chemical warfare nerve agent and catalytically decomposing the nerve agent with the MOF.

  16. Antidotes and treatments for chemical warfare/terrorism agents: an evidence-based review. (United States)

    Rodgers, G C; Condurache, C T


    This article reviews the evidence supporting the efficacy of antidotes used or recommended for the potential chemical warfare agents of most concern. Chemical warfare agents considered include cyanide, vesicants, pulmonary irritants such as chlorine and phosgene, and nerve agents. The strength of evidence for most antidotes is weak, highlighting the need for additional research in this area.

  17. Respiratory Protection Against Chemical and Biological Warfare Agents

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    G.K. Prasad


    Full Text Available Chemical and biological warfare (CBW agents pose unavoidable threat, both to soldiers and civilians.Exposure to such deadly agents amidst the CBW agents contaminated environment can be avoided bytaking proper protective measures. Respiratory protection is indispensable when the soldiers or civiliansare surrounded by such deadly environment as contamination-free air is needed for respiration purposes.In this context, an attempt has been made to review the literature for the past five decades on developmentof various protective devices for respiratory protection against aerosols, gases, and vapours of CBWagents. This review covers structural, textural, and adsorption properties of materials used in gas filtersand mechanical filters for the removal of CBW agents.Defence Science Journal, 2008, 58(5, pp.686-697, DOI:

  18. Looming Threat of Chemical and Biological Warfare Agents

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    A.K. Goel


    Full Text Available In the recent past, a dramatic shift has been observed in the strategies of warfare from conventional to non-conventional. Now-a-days, traditional power is of less importance than it used to be earlier. Weapons of mass destruction, which comprise of nuclear weapons, and chemical and biological warfare agents, are posing a great peril to the world due to their devastating potential. Though, there are several bilateral as well as multilateral treaties to control the use and proliferation of these weapons, yet the risk of use of such agents by non-state actors cannot be overlooked. Chances of use of chemical and biological agents are more likely than the nuclear weapons. A comparison of nuclear, chemical and biological weapons in terms of technology, cost, signature, effectiveness on protected and un-protected troops shows that chemical and biological weapon programmes require much lower level of technology and cost than the nuclear weapon programme. Further, there is no or least distinctive and readily observable signature in biological weapon programme in comparison to nuclear and chemical weapon facilities. There can be two possibilities of use of these agents in terrorist attacks. First, there is a risk of transfer of material or know-how of these weapons to terrorists for using against the adversaries and second, the risk of these agents being pilfered due to poor security, thereby sabotaging the national security. The International Committee of Red Cross in February 1918 reckoned these agents as ‘barbarous inventions’ that can ‘only be called criminal’.

  19. The development of immunoassays for detection of chemical warfare agents

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, D.E. [Army Medical Research Inst. of Chemical Defense, Aberdeen Proving Ground, MD (United States)


    With the advent of enzyme linked immunoabsorbant assays (ELISA) and monoclonal antibodies in the last two decades, there has been considerable effort devoted to the development of antibodies to detect and quantify low molecular weight toxic substances in environmental or biological fluids. Polyclonal antibodies against paraoxon (the toxic metabolite of parathion) were reported as capable of detecting paraoxon in body fluids at a level of 10{sup -9} M ({approximately}260 pg/mL) when used in a competitive inhibition enzyme immunoassay (CIEIA). Monoclonal antibodies developed against a structural analogue of the chemical warfare agent soman were capable of detecting soman in buffer solutions at a level of 10{sup -6} M ({approximately}180 ng/mL). In addition, these antibodies were highly specific for soman even in the presence of its major hydrolysis product. Subsequent studies with antisoman monoclonal antibodies reported an extension of the level of sensitivity to -80 ng/mL. Furthermore these antibodies did not cross react with other chemical warfare nerve agents such as sarin or tabun. In all cases, the time for a confirmatory test was two hours or less. Immunoassays for T-2 micotoxins have also been reported with a minimal detection range of 2 pg/assay to 50 ng/assay for the polyclonal and monoclonal T-2 antibodies respectively. These antibodies offer a sensitive, rapid and low cost approach to the diagnosis or detection of the presence of toxic chemical substances.

  20. LIDAR for Detection of Chemical and Biological Warfare Agents

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    S Veerabuthiran


    Full Text Available Remote detection of chemical and biological warfare agents and toxic gases in the atmosphere is of current interest to both the military and civilian agencies. Out of all currently available techniques, no single technique provides efficient detection against such threats at significant standoff distances. Light detection and ranging (LIDAR technologies, based on the transmission of laser pulses and analysis of the return signals, have demonstrated impressive capabilities in remote detection of such toxic chemicals. LIDAR is a highly sensitive tool to detect the extremely low concentrations of various toxic agents present in the form of thin clouds at distances of few kilometer. The detection of these toxic clouds is based on the approach of first detecting and measuring the range of the clouds using the scattering phenomena and subsequently identifying the composition of toxic clouds using absorption and fluorescence phenomena. Laser Science and Technology Centre (LASTEC, Delhi has been working on the design and development of LIDAR systems for detection of chemical and biological warfare (CBW agents. In this paper, theoretical analysis of differential absorption LIDAR (DIAL for detection of chemical agents and fluorescence LIDAR for detection of biological agents has been discussed. For some typical parametric conditions, the received power levels from different ranges to detect specific concentrations of chemical or biological clouds have been computed and discussed. The technical details of the indigenously developed backscattering LIDAR, which detects and measures the distance of cloud layers up to 5 km is also presented.Defence Science Journal, 2011, 61(3, pp.241-250, DOI:

  1. Methodology and biological monitoring of exposure to chemical warfare agents

    Energy Technology Data Exchange (ETDEWEB)

    Shih, M.L.; Smith, J.R.; McMonagle, J.D. [Army Medical Research Inst. of Chemical Defense, Aberdeen Proving Ground, MD (United States)


    In the past few years, our institute has developed several GC/MS methods for the detection of the breakdown products of toxic organophosphonates (soman, sarin, GF) and vesicant sulfur mustard in biological samples. Recently we developed a modified GC/MS method for VX and are continually working on the methodology for lewisite and tabun. The purpose is to have an analytical tool to verify the exposure of chemical warfare agents in humans. Analytical procedures for quantitating the hydrolyzed phosphonic acids from nerve agents in environmental samples have been reported by many analysts. For more complex matrices such as biological samples, there is not yet a method reported. To make these polar acids amenable to gas chromatographic analysis a prior derivatization is needed. We found the pentafluorobenzyl ester derivatives of the phosphonates are suitable for verification and pharmacokinetic studies in biological samples. This method may also serve as an alternative method for confirmation purposes in environmental samples.

  2. The development of immunoassays for detection of chemical warfare agents

    Energy Technology Data Exchange (ETDEWEB)

    Lenz, D.E.; Brimfield, A.A.; Cook, L. [Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD (United States)


    With the advent of enzyme linked immunoabsorbent assays (ELISA) and monoclonal antibodies in the last two decades, there has been considerable effort devoted to the development of antibodies to detect and quantify low molecular weight toxic substances in environmental or biological fluids. Polyclonal antibodies against paraoxon (the toxic metabolite of parathion) were capable of detecting paraoxon in body fluids at a level of 10{sup -9} M ({approximately}260 pg/mL) when used in a competitive inhibition enzyme immunoassay (CIEIA). Monoclonal antibodies developed against a structural analogue of the chemical warfare agent soman were capable of detection soman in buffer solutions at a level of 10{sup -6} M ({approximately}180 ng/mL). In addition these antibodies were found to be highly specific for soman even in the presence of its major hydrolysis product. Subsequent studies with antisoman monoclonal antibodies extended the level of sensitivity to {approximately}80 ng/mL. Furthermore these antibodies did not cross react with other chemical warfare nerve agents such as sarin or tabun. In all cases, the time for a confirmatory test was two hours or less. Immunoassays for T-2 micotoxins have also been reported with a minimal detection range of 2 pg/assay to 50 ng/assay for the polyclonal and monoclonal T-2 antibodies respectively. These reagents offer a sensitive, rapid and low cost approach to the diagnosis or detection of the presence of toxic chemical substances. More recent efforts have focussed on developing antibodies specific for sulfur mustard a highly reactive vesicating agent.

  3. Estimated Chemical Warfare Agent Surface Clearance Goals for Remediation Pre-Planning

    Energy Technology Data Exchange (ETDEWEB)

    Dolislager, Frederick [University of Tennessee, Knoxville (UTK); Bansleben, Dr. Donald [U.S. Department of Homeland Security; Watson, Annetta Paule [ORNL


    Health-based surface clearance goals, in units of mg/cm2, have been developed for the persistent chemical warfare agents sulfur mustard (HD) and nerve agent VX as well as their principal degradation products. Selection of model parameters and critical receptor (toddler child) allow calculation of surface residue estimates protective for the toddler child, the general population and adult employees of a facilty that has undergone chemical warfare agent attack.

  4. Key Planning Factors for Recovery from a Chemical Warfare Agent Incident (United States)


    chemical scenario involving the release of a blister agent (mustard lewisite) would result in a waste that the State of Colorado would regulate as... Waste Management ................................................................. 24 4.3 Key Planning Factors: Recovery Planning...Planning Factors, this document presents a chemical warfare agent scenario featuring Agent Yellow, a blister agent. Agent Yellow is a mixture of

  5. Platform-level Distributed Warfare Model-based on Multi-Agent System Framework

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    Xiong Li


    Full Text Available The multi-agent paradigm has become a useful tool in solving military problems. However, one of key challenges in multi-agent model for distributed warfare could be how to describe the microcosmic  tactical warfare platforms actions. In this paper, a platform-level distributed warfare model based on multi-agent system framework is designed to tackle this challenge. The basic ideas include:  Establishing multi-agent model by mapping from tactical warfare system’s members, i.e., warfare platforms, to respective agents; performing task decomposition and task allocation by using task-tree decomposition method and improved contract net protocol model technique; and implementing simulation by presenting battlefield terrain environment analysis algorithm based on grid approach. The  simulation demonstration results show that our model provides a feasible and effective approach to supporting the abstraction and representation of microcosmic tactical actions for complex warfare system.Defence Science Journal, 2012, 62(1, pp.180-186, DOI:

  6. Human scalp permeability to the chemical warfare agent VX. (United States)

    Rolland, P; Bolzinger, M-A; Cruz, C; Briançon, S; Josse, D


    The use of chemical warfare agents such as VX in terrorism act might lead to contamination of the civilian population. Human scalp decontamination may require appropriate products and procedures. Due to ethical reasons, skin decontamination studies usually involve in vitro skin models, but human scalp skin samples are uncommon and expensive. The purpose of this study was to characterize the in vitro permeability to VX of human scalp, and to compare it with (a) human abdominal skin, and (b) pig skin from two different anatomic sites: ear and skull roof, in order to design a relevant model. Based on the VX skin permeation kinetics and distribution, we demonstrated that (a) human scalp was significantly more permeable to VX than abdominal skin and (b) pig-ear skin was the most relevant model to predict the in vitro human scalp permeability. Our results indicated that the follicular pathway significantly contributed to the skin absorption of VX through human scalp. In addition, the hair follicles and the stratum corneum significantly contributed to the formation of a skin reservoir for VX.

  7. Blaptica dubia as sentinels for exposure to chemical warfare agents - a pilot study. (United States)

    Worek, Franz; Seeger, Thomas; Neumaier, Katharina; Wille, Timo; Thiermann, Horst


    The increased interest of terrorist groups in toxic chemicals and chemical warfare agents presents a continuing threat to our societies. Early warning and detection is a key component for effective countermeasures against such deadly agents. Presently available and near term solutions have a number of major drawbacks, e.g. lack of automated, remote warning and detection of primarily low volatile chemical warfare agents. An alternative approach is the use of animals as sentinels for exposure to toxic chemicals. To overcome disadvantages of vertebrates the present pilot study was initiated to investigate the suitability of South American cockroaches (Blaptica dubia) as warning system for exposure to chemical warfare nerve and blister agents. Initial in vitro experiments with nerve agents showed an increasing inhibitory potency in the order tabun - cyclosarin - sarin - soman - VX of cockroach cholinesterase. Exposure of cockroaches to chemical warfare agents resulted in clearly visible and reproducible reactions, the onset being dependent on the agent and dose. With nerve agents the onset was related to the volatility of the agents. The blister agent lewisite induced signs largely comparable to those of nerve agents while sulfur mustard exposed animals exhibited a different sequence of events. In conclusion, this first pilot study indicates that Blaptica dubia could serve as a warning system to exposure of chemical warfare agents. A cockroach-based system will not detect or identify a particular chemical warfare agent but could trigger further actions, e.g. specific detection and increased protective status. By designing appropriate boxes with (IR) motion sensors and remote control (IR) camera automated off-site warning systems could be realized.

  8. Analysis of Urinary Metabolites of Nerve and Blister Chemical Warfare Agents (United States)


    Warfare Agents GA Tabun , ethyl dimethylphosphoramidate GB Sarin, isopropyl methylphosphonofluoridate GD Soman, pinacolyl methylphosphonofluoridate...and their metabolites Agent Metabolite GA, Tabun O P O N CN Ethyl Dimethylphosphoroamidate, EDMAP, GA Acid HO P O N CN GB, Sarin P O

  9. Treatability study report for remediation of chemical warfare agent contaminated soils using peroxysulfate ex-situ treatment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Pugh, J.R.; Grinstead, J.H.; Farley, J.A.; Enlow, P.D.; Kelly, D.A.


    This laboratory scale study examines the feasibility of using peroxysulfate based oxidants to remediate soils contaminated with GB, Hi, and VX. The project was conducted with chemical warfare agent simulants. The study concludes that peroxysulfates, and particularly peroxydisulfate, can degrade chemical warfare agent simulants in soil and recommends continuing research.

  10. Ion mobility spectrometry and its applications in detection of chemical warfare agents. (United States)

    Mäkinen, Marko A; Anttalainen, Osmo A; Sillanpää, Mika E T


    When fast detection of chemical warfare agents in the field is required, the ion mobility spectrometer may be the only suitable option. This article provides an essential survey of the different ion mobility spectrometry detection technologies. (To listen to a podcast about this feature, please go to the Analytical Chemistry multimedia page at

  11. Development of Novel Alternative Technologies for Decontamination of Warfare Agents: Electric Heating with Intrinsically Conductive Polymers (United States)


    in converting electric energy to thermal energy for the decon applications. Other conductive materials, such as polythiophenes , polypyrroles, carbon...Development of Novel Alternative Technologies for Decontamination of Warfare Agents: Electric Heating with Intrinsically Conductive Polymers...Joule)-heating with conducting polymers. The basic concept is that electrically conducting polymers, such as polyaniline, can be used as coatings or

  12. Disruption of a binary organogel by the chemical warfare agent soman (GD) and common organophosphorus simulants


    Hiscock, Jennifer R.; Sambrook, Mark R; Ede, Jayne A.; Wells, Neil J.; Philip A. Gale


    The chemical warfare agent (CWA) soman (GD) acts as a molecular stimulus for the disruption of an anthracene-based binary organogel prepared in cyclohexane. The CWA simulants dimethyl methylphosphonate (DMMP) and diethyl chlorophosphate (DCP) were also found to disrupt the binary organogel through changes in solvent polarity and reactions with the gelator.\\ud \\ud

  13. On modeling of the evaporation of chemical warfare agents on the ground

    NARCIS (Netherlands)

    Westin, S.N.; Winter, S.; Karlsson, E.; Hin, A.; Oeseburg, F.


    A model for evaporation of chemical warfare agents on the ground has been developed. The process of evaporation is described in three steps: (1) the immediate drop enlargement due to impact momentum is modeled using an empirical correlation from technical literature; (2) further enlargement caused b


    Energy Technology Data Exchange (ETDEWEB)

    T. R. Twomey; A. J. Caffrey; D. L. Chichester


    Prompt gamma-ray neutron activation analysis (PGNAA) is now a proven method for the identification of chemical warfare agents and explosives in military projectiles and storage containers. Idaho National Laboratory is developing a next-generation PGNAA instrument based on the new Ortec Detective mechanically-cooled HPGe detector and a neutron generator. In this paper we review PGNAA analysis of suspect chemical warfare munitions, and we discuss the advantages and disadvantages of replacing the californium-252 radioisotopic neutron source with a compact accelerator neutron generator.

  15. Organizing for Irregular Warfare: Implications for the Brigade Combat Team (United States)


    Glenn, Russell, John Gordon, Tom Herbert, John Matsumura, Randall Steeb, and Paul Steinberg. Lightning Over Water: Sharpening America’s Light...conventional and unconventional warfare.” Special Warfare Journal, March-April (2007). Hersey , John. A Bell for Adano. New York: Vintage Books

  16. Toxicogenomic studies of human neural cells following exposure to organophosphorus chemical warfare nerve agent VX. (United States)

    Gao, Xiugong; Lin, Hsiuling; Ray, Radharaman; Ray, Prabhati


    Organophosphorus (OP) compounds represent an important group of chemical warfare nerve agents that remains a significant and constant military and civilian threat. OP compounds are considered acting primarily via cholinergic pathways by binding irreversibly to acetylcholinesterase, an important regulator of the neurotransmitter acetylcholine. Many studies over the past years have suggested that other mechanisms of OP toxicity exist, which need to be unraveled by a comprehensive and systematic approach such as genome-wide gene expression analysis. Here we performed a microarray study in which cultured human neural cells were exposed to 0.1 or 10 μM of VX for 1 h. Global gene expression changes were analyzed 6, 24, and 72 h post exposure. Functional annotation and pathway analysis of the differentially expressed genes has revealed many genes, networks and canonical pathways that are related to nervous system development and function, or to neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, and Parkinson's disease. In particular, the neuregulin pathway impacted by VX exposure has important implications in many nervous system diseases including schizophrenia. These results provide useful information valuable in developing suitable antidotes for more effective prevention and treatment of, as well as in developing biomarkers for, VX-induced chronic neurotoxicity.

  17. Chromatography and mass spectrometry of chemical warfare agents, toxins and related compounds: state of the art and future prospects

    NARCIS (Netherlands)

    Kientz, C.E.


    Methods for the identification of chemical warfare agents, toxins, bioregulators and related products are frequently reported in literature. These methods are often based on instrumental analysis using chromatography (gas and liquid) and mass spectrometry. Here, these instrumental techniques are dis

  18. Reactive skin decontamination lotion (RSDL) for the decontamination of chemical warfare agent (CWA) dermal exposure. (United States)

    Schwartz, M D; Hurst, C G; Kirk, M A; Reedy, S J D; Braue, E H


    Rapid decontamination of the skin is the single most important action to prevent dermal absorption of chemical contaminants in persons exposed to chemical warfare agents (CWA) and toxic industrial chemicals (TICs) as a result of accidental or intentional release. Chemicals on the skin may be removed by mechanical means through the use of dry sorbents or water. Recent interest in decontamination systems which both partition contaminants away from the skin and actively neutralize the chemical has led to the development of several reactive decontamination solutions. This article will review the recently FDA-approved Reactive Skin Decontamination Lotion (RSDL) and will summarize the toxicity and efficacy studies conducted to date. Evidence of RSDL's superior performance against vesicant and organophosphorus chemical warfare agents compared to water, bleach, and dry sorbents, suggests that RSDL may have a role in mass human exposure chemical decontamination in both the military and civilian arenas.

  19. Molecular modeling toward selective inhibitors of dihydrofolate reductase from the biological warfare agent Bacillus anthracis. (United States)

    Giacoppo, Juliana O S; Mancini, Daiana T; Guimarães, Ana P; Gonçalves, Arlan S; da Cunha, Elaine F F; França, Tanos C C; Ramalho, Teodorico C


    In the present work, we applied docking and molecular dynamics techniques to study 11 compounds inside the enzymes dihydrofolate reductase (DHFR) from the biological warfare agent Bacillus anthracis (BaDHFR) and Homo sapiens sapiens (HssDHFR). Six of these compounds were selected for a study with the mutant BaF96IDHFR. Our results corroborated with experimental data and allowed the proposition of a new molecule with potential activity and better selectivity for BaDHFR.

  20. Transport and Reactivity of Decontaminants to Provide Hazard Mitigation of Chemical Warfare Agents from Materials (United States)


    of Additives and Impurities from Polymeric Materials; EPA 560/5-85-015; U.S. Environmental Protection Agency, Office of Pesticides and Toxic...performance, a penetrating decontaminant may cause damage to the material, such as the swelling of polymers caused by solvents or any active...Chemical Warfare Agent Degradation Products. Environ . Health Perspect. 1999, 107 (12), 933–974. 5. Kim, K.; Tsay, O.G.; Atwood, D.A.; Churchill, D.G

  1. Ge{sup 4+} doped TiO{sub 2} for stoichiometric degradation of warfare agents

    Energy Technology Data Exchange (ETDEWEB)

    Stengl, Vaclav, E-mail: [Department of Solid State Chemistry, Institute of Inorganic Chemistry AS CR v.v.i., 250 68 Rez (Czech Republic); Grygar, Tomas Matys [Department of Solid State Chemistry, Institute of Inorganic Chemistry AS CR v.v.i., 250 68 Rez (Czech Republic); Oplustil, Frantisek; Nemec, Tomas [Military Technical Institute of Protection Brno, Veslarska 230, 628 00 Brno (Czech Republic)


    Highlights: Black-Right-Pointing-Pointer We prepared nanodisperse Ge{sup 4+} doped titania by a novel synthesis method. Black-Right-Pointing-Pointer Synthesis does not involve organic solvents, organometallics nor thermal processes. Black-Right-Pointing-Pointer The prepared materials are efficient in removal of chemical warfare agents. Black-Right-Pointing-Pointer Ge{sup 4+} doping improves rate of removal of soman and agent VX by TiO{sub 2}. - Abstract: Germanium doped TiO{sub 2} was prepared by homogeneous hydrolysis of aqueous solutions of GeCl{sub 4} and TiOSO{sub 4} with urea. The synthesized samples were characterized by X-ray diffraction, scanning electron microscopy, EDS analysis, specific surface area (BET) and porosity determination (BJH). Ge{sup 4+} doping increases surface area and content of amorphous phase in prepared samples. These oxides were used in an experimental evaluation of their reactivity with chemical warfare agent, sulphur mustard, soman and agent VX. Ge{sup 4+} doping worsens sulphur mustard degradation and improves soman and agent VX degradation. The best degree of removal (degradation), 100% of soman, 99% of agent VX and 95% of sulphur mustard, is achieved with sample with 2 wt.% of germanium.

  2. Reevaluation of 1999 Health-Based Environmental Screening Levels (HBESLs) for Chemical Warfare Agents

    Energy Technology Data Exchange (ETDEWEB)

    Watson, Annetta Paule [ORNL; Dolislager, Fredrick G [ORNL


    This report evaluates whether new information and updated scientific models require that changes be made to previously published health-based environmental soil screening levels (HBESLs) and associated environmental fate/breakdown information for chemical warfare agents (USACHPPM 1999). Specifically, the present evaluation describes and compares changes that have been made since 1999 to U.S. Environmental Protection Agency (EPA) risk assessment models, EPA exposure assumptions, as well as to specific chemical warfare agent parameters (e.g., toxicity values). Comparison was made between screening value estimates recalculated with current assumptions and earlier health-based environmental screening levels presented in 1999. The chemical warfare agents evaluated include the G-series and VX nerve agents and the vesicants sulfur mustard (agent HD) and Lewisite (agent L). In addition, key degradation products of these agents were also evaluated. Study findings indicate that the combined effect of updates and/or changes to EPA risk models, EPA default exposure parameters, and certain chemical warfare agent toxicity criteria does not result in significant alteration to the USACHPPM (1999) health-based environmental screening level estimates for the G-series and VX nerve agents or the vesicant agents HD and L. Given that EPA's final position on separate Tier 1 screening levels for indoor and outdoor worker screening assessments has not yet been released as of May 2007, the study authors find that the 1999 screening level estimates (see Table ES.1) are still appropriate and protective for screening residential as well as nonresidential sites. As such, risk management decisions made on the basis of USACHPPM (1999) recommendations do not require reconsideration. While the 1999 HBESL values are appropriate for continued use as general screening criteria, the updated '2007' estimates (presented below) that follow the new EPA protocols currently under development

  3. Enterprises as Inquiring Systems with Implications for Information Warfare (United States)


    defined as the “integrated employment of the core capabilities of electronic warfare, computer network operations, psychological operations, military...comprehension (also explicitly included in Figure 3). The entire spectrum of deception, psychological operations, and all means to impact human-centered...with the same input data (other than ground truth) via different channels and that data must be consistent within itself. The belief in empiricism to

  4. Chemiluminescence assay for the detection of biological warfare agents

    Energy Technology Data Exchange (ETDEWEB)

    Langry, K; Horn, J


    A chemiluminescent homogeneous immunoassay and a hand-size multiassay reader are described that could be used for detecting biological materials. The special feature of the assay is that it employs two different antibodies that each bind to a unique epitope on the same antigen. Each group of epitope-specific antibodies has linked to it an enzyme of a proximal-enzyme pair. One enzyme of the pair utilizes a substrate in high concentration to produce a second substrate required by the second enzyme. This new substrate enables the second enzyme to function. The reaction of the second enzyme is configured to produce light. This chemiluminescence is detected with a charge-coupled device (CCD) camera. The proximal pair enzymes must be in close proximity to one another to allow the second enzyme to react with the product of the first enzyme. This only occurs when the enzyme-linked antibodies are attached to the antigen, whether antigen is a single protein with multiple epitopes or the surface of a cell with a variety of different antigens. As a result of their juxtaposition, the enzymes produce light only in the presence of the biological material. A brief description is given as to how this assay could be utilized in a personal bio-agent detector system.

  5. Development of Bicarbonate-Activated Peroxide as a Chemical and Biological Warfare Agent Decontaminant (United States)


    Peroxide (HOO-) 7.8 29 26.7 ± 0.2 t-Butyl hydroperoxide ((CH3)3COO-) 7.8 9.7 39 Cumene hydroperoxide ((C6H6)C(CH3)2OO-) 7.8 9.3 22 All reactions run with...peroxymonocarbonate ion (HCO4-) as the oxidant in the catalytic oxidation reactions . For perhydrolytic cleavage of organophosphates the peroxycarbonate dianion...solubility and reaction rates for applications in chemical warfare agent decontamination. -O *C O O OH -O *C OH O HO *C OH O *CO2 HO2 - H2OHO *C O O OH pKa

  6. Mass Spectrometry Applications for the Identification and Quantitation of Biomarkers Resulting from Human Exposure to Chemical Warfare Agents (United States)

    Smith, J. Richard; Capacio, Benedict R.

    In recent years, a number of analytical methods using biomedical samples such as blood and urine have been developed for the verification of exposure to chemical warfare agents. The majority of methods utilize gas or liquid chromatography in conjunction with mass spectrometry. In a small number of cases of suspected human exposure to chemical warfare agents, biomedical specimens have been made available for testing. This chapter provides an overview of biomarkers that have been verified in human biomedical samples, details of the exposure incidents, the methods utilized for analysis, and the biomarker concentration levels determined in the blood and/or urine.

  7. Next Generation Non-particulate Dry Nonwoven Pad for Chemical Warfare Agent Decontamination

    Energy Technology Data Exchange (ETDEWEB)

    Ramkumar, S S; Love, A; Sata, U R; Koester, C J; Smith, W J; Keating, G A; Hobbs, L; Cox, S B; Lagna, W M; Kendall, R J


    New, non-particulate decontamination materials promise to reduce both military and civilian casualties by enabling individuals to decontaminate themselves and their equipment within minutes of exposure to chemical warfare agents or other toxic materials. One of the most promising new materials has been developed using a needlepunching nonwoven process to construct a novel and non-particulate composite fabric of multiple layers, including an inner layer of activated carbon fabric, which is well-suited for the decontamination of both personnel and equipment. This paper describes the development of a composite nonwoven pad and compares efficacy test results for this pad with results from testing other decontamination systems. The efficacy of the dry nonwoven fabric pad was demonstrated specifically for decontamination of the chemical warfare blister agent bis(2-chloroethyl)sulfide (H or sulfur mustard). GC/MS results indicate that the composite fabric was capable of significantly reducing the vapor hazard from mustard liquid absorbed into the nonwoven dry fabric pad. The mustard adsorption efficiency of the nonwoven pad was significantly higher than particulate activated carbon (p=0.041) and was similar to the currently fielded US military M291 kit (p=0.952). The nonwoven pad has several advantages over other materials, especially its non-particulate, yet flexible, construction. This composite fabric was also shown to be chemically compatible with potential toxic and hazardous liquids, which span a range of hydrophilic and hydrophobic chemicals, including a concentrated acid, an organic solvent and a mild oxidant, bleach.

  8. Investigation of Acute Toxicity of a Chemical Warfare Agent in Kidneys

    Directory of Open Access Journals (Sweden)

    Turgut Topal


    Full Text Available One of the most important chemical warfare agents, sulfur mustard (SM causes crucial acute and chronic toxic effects. Lung, skin, eye and kidneys are the most affected organs. In this work, it was investigated if increased nitric oxide (NO and peroxynitrite are involved in nitrogen mustard (NM induced kidney damage. In this experimen, aminoguanidine (AG as inducible nitric oxide synthase (iNOS inhibitor and ebselen as peroxynitrite scavenger were used. NM administration resulted in important oxidant and antioxidant changes as well as tissue damage in kidneys. Therapeutic agents showed significant protection and reduced oxidant parameteres leading to tissue healing was observed. Results of this study suggest that drugs with similar properties can be used to protect kidney damage caused by NM. [TAF Prev Med Bull. 2007; 6(4: 227-232

  9. Investigation of Acute Toxicity of a Chemical Warfare Agent in Kidneys

    Directory of Open Access Journals (Sweden)

    Turgut Topal


    Full Text Available One of the most important chemical warfare agents, sulfur mustard (SM causes crucial acute and chronic toxic effects. Lung, skin, eye and kidneys are the most affected organs. In this work, it was investigated if increased nitric oxide (NO and peroxynitrite are involved in nitrogen mustard (NM induced kidney damage. In this experimen, aminoguanidine (AG as inducible nitric oxide synthase (iNOS inhibitor and ebselen as peroxynitrite scavenger were used. NM administration resulted in important oxidant and antioxidant changes as well as tissue damage in kidneys. Therapeutic agents showed significant protection and reduced oxidant parameteres leading to tissue healing was observed. Results of this study suggest that drugs with similar properties can be used to protect kidney damage caused by NM. [TAF Prev Med Bull 2007; 6(4.000: 227-232

  10. Decontamination of adsorbed chemical warfare agents on activated carbon using hydrogen peroxide solutions. (United States)

    Osovsky, Ruth; Kaplan, Doron; Nir, Ido; Rotter, Hadar; Elisha, Shmuel; Columbus, Ishay


    Mild treatment with hydrogen peroxide solutions (3-30%) efficiently decomposes adsorbed chemical warfare agents (CWAs) on microporous activated carbons used in protective garments and air filters. Better than 95% decomposition of adsorbed sulfur mustard (HD), sarin, and VX was achieved at ambient temperatures within 1-24 h, depending on the H2O2 concentration. HD was oxidized to the nontoxic HD-sulfoxide. The nerve agents were perhydrolyzed to the respective nontoxic methylphosphonic acids. The relative rapidity of the oxidation and perhydrolysis under these conditions is attributed to the microenvironment of the micropores. Apparently, the reactions are favored due to basic sites on the carbon surface. Our findings suggest a potential environmentally friendly route for decontamination of adsorbed CWAs, using H2O2 without the need of cosolvents or activators.

  11. Multi Service Tactics, Techniques, and Procedures for Treatment of Chemical Warfare Agent Casualties and Conventional Military Chemical Injuries (United States)


    Carbon Monoxide 1 B Phosgene 3 B Hydrogen Cyanide 3 B Chlorine 4 A Cyanogen Chloride 4 A Ethylene Oxide 2 C Formaldehyde 2 B Methyl Bromide 3 B...10-7 Chlorine ............................................................................................................ 10-8...especially vulnerable and may be targeted as part of a plan to defeat U.S. force projection. Chemical warfare agents and TICs (such as chlorine , phosgene

  12. Modern sample preparation techniques for gas chromatography-mass spectrometry analysis of environmental markers of chemical warfare agents use

    NARCIS (Netherlands)

    Terzic, O.; de Voogt, P.; Banoub, J.


    The chapter introduces problematics of on-site chemical analysis in the investigations of past chemical warfare agents (CWA) events. An overview of primary environmental degradation pathways of CWA leading to formation of chemical markers of their use is given. Conventional and modern sample

  13. Rapid Ultrasensitive Chemical-Fingerprint Detection of Chemical and Biochemical Warfare Agents

    Energy Technology Data Exchange (ETDEWEB)



    Vibrational spectra can serve as chemical fingerprints for positive identification of chemical and biological warfare molecules. The required speed and sensitivity might be achieved with surface-enhanced Raman spectroscopy (SERS) using nanotextured metal surfaces. Systematic and reproducible methods for preparing metallic surfaces that maximize sensitivity have not been previously developed. This work sought to develop methods for forming high-efficiency metallic nanostructures that can be integrated with either gas or liquid-phase chem-lab-on-a-chip separation columns to provide a highly sensitive, highly selective microanalytical system for detecting current and future chem/bio agents. In addition, improved protein microchromatographic systems have been made by the creation of acrylate-based porous polymer monoliths that can serve as protein preconcentrators to reduce the optical system sensitivity required to detect and identify a particular protein, such as a bacterial toxin.

  14. Love-Wave Sensors Combined with Microfluidics for Fast Detection of Biological Warfare Agents (United States)

    Matatagui, Daniel; Fontecha, José Luis; Fernández, María Jesús; Gràcia, Isabel; Cané, Carles; Santos, José Pedro; Horrillo, María Carmen


    The following paper examines a time-efficient method for detecting biological warfare agents (BWAs). The method is based on a system of a Love-wave immunosensor combined with a microfluidic chip which detects BWA samples in a dynamic mode. In this way a continuous flow-through of the sample is created, promoting the reaction between antigen and antibody and allowing a fast detection of the BWAs. In order to prove this method, static and dynamic modes have been simulated and different concentrations of BWA simulants have been tested with two immunoreactions: phage M13 has been detected using the mouse monoclonal antibody anti-M13 (AM13), and the rabbit immunoglobulin (Rabbit IgG) has been detected using the polyclonal antibody goat anti-rabbit (GAR). Finally, different concentrations of each BWA simulants have been detected with a fast response time and a desirable level of discrimination among them has been achieved. PMID:25029282

  15. Love-Wave Sensors Combined with Microfluidics for Fast Detection of Biological Warfare Agents

    Directory of Open Access Journals (Sweden)

    Daniel Matatagui


    Full Text Available The following paper examines a time-efficient method for detecting biological warfare agents (BWAs. The method is based on a system of a Love-wave immunosensor combined with a microfluidic chip which detects BWA samples in a dynamic mode. In this way a continuous flow-through of the sample is created, promoting the reaction between antigen and antibody and allowing a fast detection of the BWAs. In order to prove this method, static and dynamic modes have been simulated and different concentrations of BWA simulants have been tested with two immunoreactions: phage M13 has been detected using the mouse monoclonal antibody anti-M13 (AM13, and the rabbit immunoglobulin (Rabbit IgG has been detected using the polyclonal antibody goat anti-rabbit (GAR. Finally, different concentrations of each BWA simulants have been detected with a fast response time and a desirable level of discrimination among them has been achieved.

  16. Love-wave sensors combined with microfluidics for fast detection of biological warfare agents. (United States)

    Matatagui, Daniel; Fontecha, José Luis; Fernández, María Jesús; Gràcia, Isabel; Cané, Carles; Santos, José Pedro; Horrillo, María Carmen


    The following paper examines a time-efficient method for detecting biological warfare agents (BWAs). The method is based on a system of a Love-wave immunosensor combined with a microfluidic chip which detects BWA samples in a dynamic mode. In this way a continuous flow-through of the sample is created, promoting the reaction between antigen and antibody and allowing a fast detection of the BWAs. In order to prove this method, static and dynamic modes have been simulated and different concentrations of BWA simulants have been tested with two immunoreactions: phage M13 has been detected using the mouse monoclonal antibody anti-M13 (AM13), and the rabbit immunoglobulin (Rabbit IgG) has been detected using the polyclonal antibody goat anti-rabbit (GAR). Finally, different concentrations of each BWA simulants have been detected with a fast response time and a desirable level of discrimination among them has been achieved.

  17. Research on the Interaction of Hydrogen-Bond Acidic Polymer Sensitive Sensor Materials with Chemical Warfare Agents Simulants by Inverse Gas Chromatography


    Liu Yang; Qiang Han; Shuya Cao; Feng Huang; Molin Qin; Chenghai Guo; Mingyu Ding


    Hydrogen-bond acidic polymers are important high affinity materials sensitive to organophosphates in the chemical warfare agent sensor detection process. Interactions between the sensor sensitive materials and chemical warfare agent simulants were studied by inverse gas chromatography. Hydrogen bonded acidic polymers, i.e., BSP3, were prepared for micro-packed columns to examine the interaction. DMMP (a nerve gas simulant) and 2-CEES (a blister agent simulant) were used as probes. Chemical an...

  18. Mass spectrometric analysis of chemical warfare agents in support of a chemical terrorist event

    Energy Technology Data Exchange (ETDEWEB)

    Hancock, J.R.; D' Agostino, P.A.; Chenier, C.L. [Defence R and D Canada Suffield, Medicine Hat, AB (Canada)


    Chemical warfare (CW) agents are considered to be any chemicals which, through their chemical action on life processes can cause death, temporary incapacitation or permanent harm to humans or animals. In Canada, the probability of a CW terrorist attack is low despite the catastrophic consequences that would result from such an attack. The three levels of government would be responding to such an event. CW agent response training for all levels of government is offered at Defence R and D Canada-Suffield. Appropriate samples must be collected for analysis in a laboratory, as such an event would lead to a criminal investigation. Research into new methods for the identification of CW agents is being conducted by the analytical laboratory at Defence R and D Canada-Suffield. Gas chromatography and mass spectrometry (GC-MS) are being used extensively to separate and characterize CW agents in organic extracts. In the case of aqueous samples, another method might be more appropriate, since additional sample handling is required before GC-MS analysis can be performed. Minimal sample handling is required when using liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) for direct analysis of CW agents. The authors demonstrated the use of LC-ESI-MS for analyzing CW agents and their hydrolysis products in aqueous samples. For the analysis of nerve agents and phosphonic acids in soil, comparable or superior results to organic extraction and GC-MS were obtained for aqueous extractions followed by LC-ESI-MS. The combination of GC-MS and LC-ESI-MS for the analysis of mustard related compounds in soil extracts from a former mustard storage area showed that the two methods are complementary in this situation. 9 refs., 3 tabs., 5 figs.

  19. Limitations and challenges in treatment of acute chemical warfare agent poisoning. (United States)

    Thiermann, Horst; Worek, Franz; Kehe, Kai


    Recent news from Syria on a possible use of chemical warfare agents made the headlines. Furthermore, the motivation of terrorists to cause maximal harm shifts these agents into the public focus. For incidents with mass casualties appropriate medical countermeasures must be available. At present, the most important threats arise from nerve agents and sulfur mustard. At first, self-protection and protection of medical units from contamination is of utmost importance. Volatile nerve agent exposure, e.g. sarin, results in fast development of cholinergic crisis. Immediate clinical diagnosis can be confirmed on-site by assessment of acetylcholinesterase activity. Treatment with autoinjectors that are filled with 2mg atropine and an oxime (at present obidoxime, pralidoxime, TMB-4 or HI-6) are not effective against all nerve agents. A more aggressive atropinisation has to be considered and more effective oximes (if possible with a broad spectrum or a combination of different oximes) as well as alternative strategies to cope with high acetylcholine levels at synaptic sites should be developed. A further gap exists for the treatment of patients with sustained cholinergic crisis that has to be expected after exposure to persistent nerve agents, e.g. VX. The requirement for long-lasting artificial ventilation can be reduced with an oxime therapy that is optimized by using the cholinesterase status for guidance or by measures (e.g. scavengers) that are able to reduce the poison load substantially in the patients. For sulfur mustard poisoning no specific antidote is available until now. Symptomatic measures as used for treatment of burns are recommended together with surgical or laser debridement. Thus, huge amounts of resources are expected to be consumed as wound healing is impaired. Possible depots of sulfur mustard in tissues may aggravate the situation. More basic knowledge is necessary to improve substantially therapeutic options. The use of stem cells may provide a new

  20. Efficacy of liquid and foam decontamination technologies for chemical warfare agents on indoor surfaces. (United States)

    Love, Adam H; Bailey, Christopher G; Hanna, M Leslie; Hok, Saphon; Vu, Alex K; Reutter, Dennis J; Raber, Ellen


    Bench-scale testing was used to evaluate the efficacy of four decontamination formulations on typical indoor surfaces following exposure to the liquid chemical warfare agents sarin (GB), soman (GD), sulfur mustard (HD), and VX. Residual surface contamination on coupons was periodically measured for up to 24h after applying one of four selected decontamination technologies [0.5% bleach solution with trisodium phosphate, Allen Vanguard Surface Decontamination Foam (SDF™), U.S. military Decon Green™, and Modec Inc. and EnviroFoam Technologies Sandia Decontamination Foam (DF-200)]. All decontamination technologies tested, except for the bleach solution, performed well on nonporous and nonpermeable glass and stainless-steel surfaces. However, chemical agent residual contamination typically remained on porous and permeable surfaces, especially for the more persistent agents, HD and VX. Solvent-based Decon Green™ performed better than aqueous-based bleach or foams on polymeric surfaces, possibly because the solvent is able to penetrate the polymer matrix. Bleach and foams out-performed Decon Green for penetrating the highly polar concrete surface. Results suggest that the different characteristics needed for an ideal and universal decontamination technology may be incompatible in a single formulation and a strategy for decontaminating a complex facility will require a range of technologies.

  1. Multifunctional ultra-high vacuum apparatus for studies of the interactions of chemical warfare agents on complex surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Wilmsmeyer, Amanda R.; Morris, John R. [Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061 (United States); Gordon, Wesley O.; Mantooth, Brent A.; Lalain, Teri A. [Research and Technology Directorate, U.S. Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland 21010 (United States); Davis, Erin Durke [OptiMetrics, Inc., Abingdon, Maryland 21009 (United States)


    A fundamental understanding of the surface chemistry of chemical warfare agents is needed to fully predict the interaction of these toxic molecules with militarily relevant materials, catalysts, and environmental surfaces. For example, rules for predicting the surface chemistry of agents can be applied to the creation of next generation decontaminants, reactive coatings, and protective materials for the warfighter. Here, we describe a multifunctional ultra-high vacuum instrument for conducting comprehensive studies of the adsorption, desorption, and surface chemistry of chemical warfare agents on model and militarily relevant surfaces. The system applies reflection-absorption infrared spectroscopy, x-ray photoelectron spectroscopy, and mass spectrometry to study adsorption and surface reactions of chemical warfare agents. Several novel components have been developed to address the unique safety and sample exposure challenges that accompany the research of these toxic, often very low vapor pressure, compounds. While results of vacuum-based surface science techniques may not necessarily translate directly to environmental processes, learning about the fundamental chemistry will begin to inform scientists about the critical aspects that impact real-world applications.

  2. Ultra-Fast Degradation of Chemical Warfare Agents Using MOF-Nanofiber Kebabs. (United States)

    Zhao, Junjie; Lee, Dennis T; Yaga, Robert W; Hall, Morgan G; Barton, Heather F; Woodward, Ian R; Oldham, Christopher J; Walls, Howard J; Peterson, Gregory W; Parsons, Gregory N


    The threat associated with chemical warfare agents (CWAs) motivates the development of new materials to provide enhanced protection with a reduced burden. Metal-organic frame-works (MOFs) have recently been shown as highly effective catalysts for detoxifying CWAs, but challenges still remain for integrating MOFs into functional filter media and/or protective garments. Herein, we report a series of MOF-nanofiber kebab structures for fast degradation of CWAs. We found TiO2 coatings deposited via atomic layer deposition (ALD) onto polyamide-6 nanofibers enable the formation of conformal Zr-based MOF thin films including UiO-66, UiO-66-NH2 , and UiO-67. Cross-sectional TEM images show that these MOF crystals nucleate and grow directly on and around the nanofibers, with strong attachment to the substrates. These MOF-functionalized nanofibers exhibit excellent reactivity for detoxifying CWAs. The half-lives of a CWA simulant compound and nerve agent soman (GD) are as short as 7.3 min and 2.3 min, respectively. These results therefore provide the earliest report of MOF-nanofiber textile composites capable of ultra-fast degradation of CWAs.

  3. The possible role of intravenous lipid emulsion in the treatment of chemical warfare agent poisoning

    Directory of Open Access Journals (Sweden)

    Arik Eisenkraft


    Full Text Available Organophosphates (OPs are cholinesterase inhibitors that lead to a characteristic toxidrome of hypersecretion, miosis, dyspnea, respiratory insufficiency, convulsions and, without proper and early antidotal treatment, death. Most of these compounds are highly lipophilic. Sulfur mustard is a toxic lipophilic alkylating agent, exerting its damage through alkylation of cellular macromolecules (e.g., DNA, proteins and intense activation of pro-inflammatory pathways. Currently approved antidotes against OPs include the peripheral anticholinergic drug atropine and an oxime that reactivates the inhibited cholinesterase. Benzodiazepines are used to stop organophosphate-induced seizures. Despite these approved drugs, efforts have been made to introduce other medical countermeasures in order to attenuate both the short-term and long-term clinical effects following exposure. Currently, there is no antidote against sulfur mustard poisoning. Intravenous lipid emulsions are used as a source of calories in parenteral nutrition. In recent years, efficacy of lipid emulsions has been shown in the treatment of poisoning by fat-soluble compounds in animal models as well as clinically in humans. In this review we discuss the usefulness of intravenous lipid emulsions as an adjunct to the in-hospital treatment of chemical warfare agent poisoning.

  4. Fate of chemical warfare agents and toxic industrial chemicals in landfills. (United States)

    Bartelt-Hunt, Shannon L; Barlaz, Morton A; Knappe, Detlef R U; Kjeldsen, Peter


    One component of preparedness for a chemical attack is planning for the disposal of contaminated debris. To assess the feasibility of contaminated debris disposal in municipal solid waste (MSW) landfills, the fate of selected chemical warfare agents (CWAs) and toxic industrial chemicals (TICs) in MSW landfills was predicted with a mathematical model. Five blister agents [sulfur mustard (HD), nitrogen mustard (HN-2), lewisite (L), ethyldichloroarsine (ED), and phosgene oxime (CX)], eight nerve agents [tabun (GA), sarin (GB), soman (GD), GE, GF, VX, VG, and VM], one riot-control agent [CS], and two TICs [furan and carbon disulfide] were studied. The effects of both infiltration (climate) and contaminant biodegradability on fate predictions were assessed. Model results showed that hydrolysis and gas-phase advection were the principal fate pathways for CWAs and TICs, respectively. Apart from CX and the TICs, none of the investigated compounds was predicted to persist in a landfill for more than 5 years. Climate had little impact on CWA/TIC fate, and biodegradability was only important for compounds with long hydrolysis half-lives. Monte Carlo simulations were performed to assess the influence of uncertainty in model input parameters on CWA/TIC fate predictions. Correlation analyses showed that uncertainty in hydrolysis rate constants was the primary contributor to variance of CWA fate predictions, while uncertainty in the Henry's Law constant and landfill gas-production rate accounted for most of the variance of TIC fate predictions. CWA hydrolysates were more persistent than the parent CWAs, but limited information is available on abiotic or biotic transformation rates for these chemicals.

  5. Biological Warfare Agents, Toxins, Vectors and Pests as Biological Terrorism Agents (United States)


    synthesis of >100 amino acid polypeptides, advanced genetic manipulation). Toxins as terrorism agents: 1. Botulinum toxin 2. Ricin 3...marginatum 5. Hyalomma Anatolicum Anatolicum 6. Dermacentor spp. 7. Rhipicephalus spp. 8. Amblyomma spp. 9. Mansonia spp. 10. Culex spp. 11

  6. Advances in toxicology and medical treatment of chemical warfare nerve agents

    Directory of Open Access Journals (Sweden)

    Moshiri Mohammd


    Full Text Available Abstract Organophosphorous (OP Nerve agents (NAs are known as the deadliest chemical warfare agents. They are divided into two classes of G and V agents. Most of them are liquid at room temperature. NAs chemical structures and mechanisms of actions are similar to OP pesticides, but their toxicities are higher than these compounds. The main mechanism of action is irreversible inhibition of Acetyl Choline Esterase (AChE resulting in accumulation of toxic levels of acetylcholine (ACh at the synaptic junctions and thus induces muscarinic and nicotinic receptors stimulation. However, other mechanisms have recently been described. Central nervous system (CNS depression particularly on respiratory and vasomotor centers may induce respiratory failure and cardiac arrest. Intermediate syndrome after NAs exposure is less common than OP pesticides poisoning. There are four approaches to detect exposure to NAs in biological samples: (I AChE activity measurement, (II Determination of hydrolysis products in plasma and urine, (III Fluoride reactivation of phosphylated binding sites and (IV Mass spectrometric determination of cholinesterase adducts. The clinical manifestations are similar to OP pesticides poisoning, but with more severity and fatalities. The management should be started as soon as possible. The victims should immediately be removed from the field and treatment is commenced with auto-injector antidotes (atropine and oximes such as MARK I kit. A 0.5% hypochlorite solution as well as novel products like M291 Resin kit, G117H and Phosphotriesterase isolated from soil bacterias, are now available for decontamination of NAs. Atropine and oximes are the well known antidotes that should be infused as clinically indicated. However, some new adjuvant and additional treatment such as magnesium sulfate, sodium bicarbonate, gacyclidine, benactyzine, tezampanel, hemoperfusion, antioxidants and bioscavengers have recently been used for OP NAs poisoning.

  7. Plastic antibody for the recognition of chemical warfare agent sulphur mustard. (United States)

    Boopathi, M; Suryanarayana, M V S; Nigam, Anil Kumar; Pandey, Pratibha; Ganesan, K; Singh, Beer; Sekhar, K


    Molecularly imprinted polymers (MIPs) known as plastic antibodies (PAs) represent a new class of materials possessing high selectivity and affinity for the target molecule. Since their discovery, PAs have attracted considerable interest from bio- and chemical laboratories to pharmaceutical institutes. PAs are becoming an important class of synthetic materials mimicking molecular recognition by natural receptors. In addition, they have been utilized as catalysts, sorbents for solid-phase extraction, stationary phase for liquid chromatography and mimics of enzymes. In this paper, first time we report the preparation and characterization of a PA for the recognition of blistering chemical warfare agent sulphur mustard (SM). The SM imprinted PA exhibited more surface area when compared to the control non-imprinted polymer (NIP). In addition, SEM image showed an ordered nano-pattern for the PA of SM that is entirely different from the image of NIP. The imprinting also enhanced SM rebinding ability to the PA when compared to the NIP with an imprinting efficiency (alpha) of 1.3.

  8. Measurements of Raman scattering in the middle ultraviolet band from persistent chemical warfare agents (United States)

    Kullander, Fredrik; Landström, Lars; Lundén, Hampus; Mohammed, Abdesalam; Olofsson, Göran; Wästerby, Pär.


    The very low Raman scattering cross section and the fluorescence background limit the measuring range of Raman based instruments operating in the visible or infrared band. We are exploring if laser excitation in the middle ultraviolet (UV) band between 200 and 300 nm is useful and advantageous for detection of persistent chemical warfare agents (CWA) on various kinds of surfaces. The UV Raman scattering from tabun, mustard gas, VX and relevant simulants in the form of liquid surface contaminations has been measured using a laboratory experimental setup with a short standoff distance around 1 meter. Droplets having a volume of 1 μl were irradiated with a tunable pulsed laser swept within the middle UV band. A general trend is that the signal strength moves through an optimum when the laser excitation wavelength is swept between 240 and 300 nm. The signal from tabun reaches a maximum around 265 nm, the signal from mustard gas around 275 nm. The Raman signal from VX is comparably weak. Raman imaging by the use of a narrow bandpass UV filter is also demonstrated.

  9. Modified clay minerals efficiency against chemical and biological warfare agents for civil human protection. (United States)

    Plachá, Daniela; Rosenbergová, Kateřina; Slabotínský, Jiří; Kutláková, Kateřina Mamulová; Studentová, Soňa; Martynková, Gražyna Simha


    Sorption efficiencies of modified montmorillonite and vermiculite of their mono ionic Na and organic HDTMA and HDP forms were studied against chemical and biological warfare agents such as yperite and selected bacterial strains. Yperite interactions with modified clay minerals were observed through its capture in low-density polyethylene foil-modified clay composites by measuring yperite gas permeation with using chemical indication and gas chromatography methods. The antibacterial activities of synthetized organoclays were tested against selected Gram-positive and Gram-negative bacterial species in minimum inhibitory concentration tests. The obtained results showed a positive influence of modified clay minerals on the significant yperite breakthrough-time increase. The most effective material was the polyethylene-Na form montmorillonite, while the polyethylene-Na form vermiculite showed the lowest efficiency. With increasing organic cations loading in the interlayer space the montmorillonite efficiency decreased, and in the case of vermiculite an opposite effect was observed. Generally the modified montmorillonites were more effective than modified vermiculites. The HDP cations seem to be more effective compare to the HDTMA. The antibacterial activity tests confirmed efficiency of all organically modified clay minerals against Gram-positive bacteria. The confirmation of antibacterial activity against Y. pestis, plague bacteria, is the most interesting result of this part of the study.

  10. Surface plasmon resonance detection of biological warfare agent Staphylococcal enterotoxin B using high affinity monoclonal antibody

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, Garima; Singh, Pawan K.; Boopathi, M., E-mail:; Kamboj, D.V.; Singh, Beer; Vijayaraghavan, R.


    A novel sensitive method was developed for the detection as well as quantification of Staphylococcal enterotoxin B (SEB) using surface plasmon resonance (SPR). It is well known that the amount of SEB needed to cause the intoxication to human beings is very less and this concentration (0.02 {mu}g/kg) is highly dangerous, hence, it is used as biological warfare agent. Thus, the need to develop a reliable and potential detection system against SEB is warranted. In the present work, SEB antibody was immobilized on carboxymethyldextran modified gold chip. The immobilization of SEB antibody and interaction of antigen with immobilized antibody were in-situ characterized by SPR and electrochemical impedance spectroscopy. A sample solution containing SEB antigen was injected in a working channel and the results revealed linearity in the concentration from 2.0 to 32.0 pM with a detection limit of 1.0 pM. By using kinetic evaluation software, K{sub D} (equilibrium constant) and Bmax (maximum binding capacity of analyte) values were calculated and found to be 13 pM and 424.23, respectively. Moreover, the thermodynamic parameter, change in Gibb's free energy was deduced and found to be -62.08 kJ/mol and this value shows the spontaneous interaction between SEB antigen and SEB antibody. In order to optimize the detection method, temperature and pH variation studies were also performed. Interference study was conducted to know the selectivity for the antigen-antibody interaction of SEB. The selectivity efficiency of SEB, SEC, SEA and SED were 100, 27.15, 20.01 and 12.05%, respectively towards SEB antibody.

  11. Multiple functional UV devices based on III-Nitride quantum wells for biological warfare agent detection (United States)

    Wang, Qin; Savage, Susan; Persson, Sirpa; Noharet, Bertrand; Junique, Stéphane; Andersson, Jan Y.; Liuolia, Vytautas; Marcinkevicius, Saulius


    We have demonstrated surface normal detecting/filtering/emitting multiple functional ultraviolet (UV) optoelectronic devices based on InGaN/GaN, InGaN/AlGaN and AlxGa1-xN/AlyGa1-yN multiple quantum well (MQW) structures with operation wavelengths ranging from 270 nm to 450 nm. Utilizing MQW structure as device active layer offers a flexibility to tune its long cut-off wavelength in a wide UV range from solar-blind to visible by adjusting the well width, well composition and barrier height. Similarly, its short cut-off wavelength can be adjusted by using a GaN or AlGaN block layer on a sapphire substrate when the device is illuminated from its backside, which further provides an optical filtering effect. When a current injects into the device under forward bias the device acts as an UV light emitter, whereas the device performs as a typical photodetector under reverse biases. With applying an alternating external bias the device might be used as electroabsorption modulator due to quantum confined Stark effect. In present work fabricated devices have been characterized by transmission/absorption spectra, photoresponsivity, electroluminescence, and photoluminescence measurements under various forward and reverse biases. The piezoelectric effect, alloy broadening and Stokes shift between the emission and absorption spectra in different InGaN- and AlGaN-based QW structures have been investigated and compared. Possibilities of monolithic or hybrid integration using such multiple functional devices for biological warfare agents sensing application have also be discussed.

  12. Research on the Interaction of Hydrogen-Bond Acidic Polymer Sensitive Sensor Materials with Chemical Warfare Agents Simulants by Inverse Gas Chromatography

    Directory of Open Access Journals (Sweden)

    Liu Yang


    Full Text Available Hydrogen-bond acidic polymers are important high affinity materials sensitive to organophosphates in the chemical warfare agent sensor detection process. Interactions between the sensor sensitive materials and chemical warfare agent simulants were studied by inverse gas chromatography. Hydrogen bonded acidic polymers, i.e., BSP3, were prepared for micro-packed columns to examine the interaction. DMMP (a nerve gas simulant and 2-CEES (a blister agent simulant were used as probes. Chemical and physical parameters such as heats of absorption and Henry constants of the polymers to DMMP and 2-CEES were determined by inverse gas chromatography. Details concerning absorption performance are also discussed in this paper.

  13. Research on the interaction of hydrogen-bond acidic polymer sensitive sensor materials with chemical warfare agents simulants by inverse gas chromatography. (United States)

    Yang, Liu; Han, Qiang; Cao, Shuya; Huang, Feng; Qin, Molin; Guo, Chenghai; Ding, Mingyu


    Hydrogen-bond acidic polymers are important high affinity materials sensitive to organophosphates in the chemical warfare agent sensor detection process. Interactions between the sensor sensitive materials and chemical warfare agent simulants were studied by inverse gas chromatography. Hydrogen bonded acidic polymers, i.e., BSP3, were prepared for micro-packed columns to examine the interaction. DMMP (a nerve gas simulant) and 2-CEES (a blister agent simulant) were used as probes. Chemical and physical parameters such as heats of absorption and Henry constants of the polymers to DMMP and 2-CEES were determined by inverse gas chromatography. Details concerning absorption performance are also discussed in this paper.

  14. Particle Swarm Social Adaptive Model for Multi-Agent Based Insurgency Warfare Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Cui, Xiaohui [ORNL; Potok, Thomas E [ORNL


    To better understand insurgent activities and asymmetric warfare, a social adaptive model for modeling multiple insurgent groups attacking multiple military and civilian targets is proposed and investigated. This report presents a pilot study using the particle swarm modeling, a widely used non-linear optimal tool to model the emergence of insurgency campaign. The objective of this research is to apply the particle swarm metaphor as a model of insurgent social adaptation for the dynamically changing environment and to provide insight and understanding of insurgency warfare. Our results show that unified leadership, strategic planning, and effective communication between insurgent groups are not the necessary requirements for insurgents to efficiently attain their objective.

  15. Estimating areas threatened by contamination from leaking chemical warfare agents dumped into the Baltic Sea (United States)

    Jakacki, Jaromir; Przyborska, Anna; Andrzejewski, Jan


    Approximately 60,000 tons of chemical munitions were dumped into the Baltic Sea after World War II (the exact amount is unknown and some sources estimate it as more than 200,000 tons). Dumped munitions still pose a risk of leakage caused by erosion and corrosion, and it is important to know the danger areas. Because of wide dispersion of the dumped munitions, modelling is only one tool that could provide wide image of physical state of the sea at all locations and which could also be used for analysing contamination during a potential leakage. Obviously, it is possible to take samples at each dumpsite, but modelling also allows to develop possible scenarios of leakages under specific physical conditions. For the purpose of analysis of potential leakage a high-resolution model (HRM) of the contamination will be embedded in the hydrodynamic model (HM) of the Baltic Sea. The HRM will use data from general circulation model results of estimated resolution of nearly 2 km. The Parallel Ocean Program will be implemented as the HM for the whole Baltic Sea. Atmospheric data from regional implementation of the Weather Research and Forecasting System (WRF) have been used as the top boundary conditions of the HM, and sea level data from Gothenburg had been included into model barotropic equation as lateral boundary conditions. Passive tracer will represent the contamination in the HRM and horizontal resolution of the HRM will be close to 50 meters. Passive tracers will also be implemented in the HM - for comparison of the results. For proper representation of potential leakage of chemical warfare agents the HRM will have included diffusion and advection processes. The results from the HM are going to be interpolated into the HRM domain and then integration will be performed. Based on the implemented simulations, estimated contaminated area and its comparison from the HRM as well as from the HM will be presented. The research work was fund by the European Union (European

  16. Evaluation of Chemical Warfare Agent Percutaneous Vapor Toxicity: Derivation of Toxicity Guidelines for Assessing Chemical Protective Ensembles.

    Energy Technology Data Exchange (ETDEWEB)

    Watson, A.P.


    Percutaneous vapor toxicity guidelines are provided for assessment and selection of chemical protective ensembles (CPEs) to be used by civilian and military first responders operating in a chemical warfare agent vapor environment. The agents evaluated include the G-series and VX nerve agents, the vesicant sulfur mustard (agent HD) and, to a lesser extent, the vesicant Lewisite (agent L). The focus of this evaluation is percutaneous vapor permeation of CPEs and the resulting skin absorption, as inhalation and ocular exposures are assumed to be largely eliminated through use of SCBA and full-face protective masks. Selection of appropriately protective CPE designs and materials incorporates a variety of test parameters to ensure operability, practicality, and adequacy. One aspect of adequacy assessment should be based on systems tests, which focus on effective protection of the most vulnerable body regions (e.g., the groin area), as identified in this analysis. The toxicity range of agent-specific cumulative exposures (Cts) derived in this analysis can be used as decision guidelines for CPE acceptance, in conjunction with weighting consideration towards more susceptible body regions. This toxicity range is bounded by the percutaneous vapor estimated minimal effect (EME{sub pv}) Ct (as the lower end) and the 1% population threshold effect (ECt{sub 01}) estimate. Assumptions of exposure duration used in CPE certification should consider that each agent-specific percutaneous vapor cumulative exposure Ct for a given endpoint is a constant for exposure durations between 30 min and 2 hours.

  17. Wearable Atmospheric Pressure Plasma Fabrics Produced by Knitting Flexible Wire Electrodes for the Decontamination of Chemical Warfare Agents (United States)

    Jung, Heesoo; Seo, Jin Ah; Choi, Seungki


    One of the key reasons for the limited use of atmospheric pressure plasma (APP) is its inability to treat non-flat, three-dimensional (3D) surface structures, such as electronic devices and the human body, because of the rigid electrode structure required. In this study, a new APP system design—wearable APP (WAPP)—that utilizes a knitting technique to assemble flexible co-axial wire electrodes into a large-area plasma fabric is presented. The WAPP device operates in ambient air with a fully enclosed power electrode and grounded outer electrode. The plasma fabric is flexible and lightweight, and it can be scaled up for larger areas, making it attractive for wearable APP applications. Here, we report the various plasma properties of the WAPP device and successful test results showing the decontamination of toxic chemical warfare agents, namely, mustard (HD), soman (GD), and nerve (VX) agents.

  18. Dual-Function Metal-Organic Framework as a Versatile Catalyst for Detoxifying Chemical Warfare Agent Simulants. (United States)

    Liu, Yangyang; Moon, Su-Young; Hupp, Joseph T; Farha, Omar K


    The nanocrystals of a porphyrin-based zirconium(IV) metal-organic framework (MOF) are used as a dual-function catalyst for the simultaneous detoxification of two chemical warfare agent simulants at room temperature. Simulants of nerve agent (such as GD, VX) and mustard gas, dimethyl 4-nitrophenyl phosphate and 2-chloroethyl ethyl sulfide, have been hydrolyzed and oxidized, respectively, to nontoxic products via a pair of pathways catalyzed by the same MOF. Phosphotriesterase-like activity of the Zr6-containing node combined with photoactivity of the porphyrin linker gives rise to a versatile MOF catalyst. In addition, bringing the MOF crystals down to the nanoregime leads to acceleration of the catalysis.

  19. Hand-held analyser based on microchip electrophoresis with contactless conductivity detection for measurement of chemical warfare agent degradation products (United States)

    Duran, Karolina-Petkovic; Zhu, Yonggang; Chen, Chuanpin; Swallow, Anthony; Stewart, Robert; Hoobin, Pam; Leech, Patrick; Ovenden, Simon


    This paper reports on the development of a hand-held device for on-site detection of organophosphonate nerve agent degradation products. This field-deployable analyzer relies on efficient microchip electrophoresis separation of alkyl methylphosphonic acids and their sensitive contactless conductivity detection. Miniaturized, low-powered design is coupled with promising analytical performance for separating the breakdown products of chemical warfare agents such as Soman, Sarin and VX . The detector has a detection limit of about 10 μg/mL and has a good linear response in the range 10-300 μg/mL concentration range. Applicability to environmental samples is demonstrated .The new hand-held analyzer offers great promise for converting conventional ion chromatography or capillary electrophoresis sophisticated systems into a portable forensic laboratory for faster, simpler and more reliable on-site screening.

  20. Evaluation of Molecular Markers and Analytical Methods Documenting the Occurrence of Mustard Gas and Arsenical Warfare Agents in Soil. (United States)

    Sassolini, Alessandro; Brinchi, Giampaolo; Di Gennaro, Antonio; Dionisi, Simone; Dominici, Carola; Fantozzi, Luca; Onofri, Giorgio; Piazza, Rosario; Guidotti, Maurizio


    The chemicals warfare agents (CWAs) are an extremely toxic class of molecules widely produced in many industrialized countries for decades, these compounds frequently contained arsenic. The plants where the CWAs have been produced or the plants where they have been demilitarized after the Second World War with unacceptable techniques can represent a serious environmental problem. CWAs standards are difficult to find on market so in present work an environmental assessment method based on markers has been proposed. Triphenylarsine, phenylarsine oxide and thiodiglycol have been selected as markers. Three reliable analytical methods based on gaschromatography and mass detection have been proposed and tested for quantitative analysis of markers. Methods performance have been evaluated testing uncertainty, linearity, recovery and detection limits and also comparing detection limits with exposure limits of reference CWAs. Proposed assessment methods have been applied to a case study of a former industrial plant sited in an area characterized by a high background of mineral arsenic.

  1. NATO Advanced Research Workshop on Fluorescence and other Optical Properties of Biological Particles for Biological Warfare Agent Sensors

    CERN Document Server

    Hoekstra, Alfons; Videen, Gorden; Optics of Biological Particles


    This book covers the optics of single biological particles, both theory and experiment, with emphasis on Elastic Light Scattering and Fluorescence. It deals with the optics of bacteria (bio-aerosols), marine particles (selected phytoplankton communities) and red and white blood cells. Moreover, there are dedicated chapters on a general theory for scattering by a cell, and modelling and simulation of scattering by inhomogeneous biological cells. Finally, one chapter is dedicated to astro-biological signatures, discussing the possibilities for detecting non-terrestrial biological material. The volume has up-to-date discussions on new experimental and numerical techniques, and many examples of applications of these techniques in real-life systems, as used to detect and characterize e.g. biological warfare agents or human blood cells.

  2. Capillary zone electrophoresis analysis and detection of mid-spectrum biological warfare agents. Suffield memorandum No. 1463

    Energy Technology Data Exchange (ETDEWEB)

    Boulet, C.A.


    Mid-spectrum biological warfare agents such as proteins, peptides, and toxins are often difficult to analyze and often require individually developed assay methods for detection and identification. In this regard, capillary electrophoresis is an important, emerging technique for separation and quantitation of peptides and proteins, providing separation efficiencies up to two orders of magnitude greater than high performance liquid chromatography. The technique can also analyze a broad range of compounds, has a simple instrument design which can be automated, and has low sample volume requirements. In this study, a highly efficient and reproducible capillary zone electrophoresis method was developed to separate and identify a series of nine peptides of defense interest including bradykinin, leucine enkephalin, and oxytocin. The paper demonstrates three strategies which could be used in a fully automated field detection and identification system for unknown peptides.

  3. How Do I Know? A Guide to the Selection of Personal Protective Equipment for Use in Responding to A Release of Chemical Warfare Agents

    Energy Technology Data Exchange (ETDEWEB)

    Foust, C.B.


    An incident involving chemical warfare agents requires a unique hazardous materials (HAZMAT) response. As with an HAZMAT event, federal regulations prescribe that responders must be protected from exposure to the chemical agents. But unlike other HAZMAT events, special considerations govern selection of personal protective equipment (PPE). PPE includes all clothing, respirators and monitoring devices used to respond to a chemical release. PPE can differ depending on whether responders are military or civilian personnel.

  4. In Situ Probes of Capture and Decomposition of Chemical Warfare Agent Simulants by Zr-Based Metal Organic Frameworks

    Energy Technology Data Exchange (ETDEWEB)

    Plonka, Anna M.; Wang, Qi; Gordon, Wesley O.; Balboa, Alex; Troya, Diego; Guo, Weiwei; Sharp, Conor H.; Senanayake, Sanjaya D.; Morris, John R.; Hill, Craig L.; Frenkel, Anatoly I. (BNL); (Virginia Tech); (ECBC); (Emory); (SBU)


    Zr-based metal organic frameworks (MOFs) have been recently shown to be among the fastest catalysts of nerve-agent hydrolysis in solution. We report a detailed study of the adsorption and decomposition of a nerve-agent simulant, dimethyl methylphosphonate (DMMP), on UiO-66, UiO-67, MOF-808, and NU-1000 using synchrotron-based X-ray powder diffraction, X-ray absorption, and infrared spectroscopy, which reveals key aspects of the reaction mechanism. The diffraction measurements indicate that all four MOFs adsorb DMMP (introduced at atmospheric pressures through a flow of helium or air) within the pore space. In addition, the combination of X-ray absorption and infrared spectra suggests direct coordination of DMMP to the Zr6 cores of all MOFs, which ultimately leads to decomposition to phosphonate products. These experimental probes into the mechanism of adsorption and decomposition of chemical warfare agent simulants on Zr-based MOFs open new opportunities in rational design of new and superior decontamination materials.

  5. Efficient hydrolysis of the chemical warfare nerve agent tabun by recombinant and purified human and rabbit serum paraoxonase 1. (United States)

    Valiyaveettil, Manojkumar; Alamneh, Yonas; Biggemann, Lionel; Soojhawon, Iswarduth; Doctor, Bhupendra P; Nambiar, Madhusoodana P


    Paraoxonase 1 (PON1) has been described as an efficient catalytic bioscavenger due to its ability to hydrolyze organophosphates (OPs) and chemical warfare nerve agents (CWNAs). It is the future most promising candidate as prophylactic medical countermeasure against highly toxic OPs and CWNAs. Most of the studies conducted so far have been focused on the hydrolyzing potential of PON1 against nerve agents, sarin, soman, and VX. Here, we investigated the hydrolysis of tabun by PON1 with the objective of comparing the hydrolysis potential of human and rabbit serum purified and recombinant human PON1. The hydrolysis potential of PON1 against tabun, sarin, and soman was evaluated by using an acetylcholinesterase (AChE) back-titration Ellman method. Efficient hydrolysis of tabun (100 nM) was observed with ∼25-40 mU of PON1, while higher concentration (80-250 mU) of the enzyme was required for the complete hydrolysis of sarin (11 nM) and soman (3 nM). Our data indicate that tabun hydrolysis with PON1 was ∼30-60 times and ∼200-260 times more efficient than that with sarin and soman, respectively. Moreover, the catalytic activity of PON1 varies from source to source, which also reflects their efficiency of hydrolyzing different types of nerve agents. Thus, efficient hydrolysis of tabun by PON1 suggests its promising potential as a prophylactic treatment against tabun exposure.

  6. Using Metal Complex Ion-Molecule Reactions in a Miniature Rectilinear Ion Trap Mass Spectrometer to Detect Chemical Warfare Agents (United States)

    Graichen, Adam M.; Vachet, Richard W.


    The gas-phase reactions of a series of coordinatively unsaturated [Ni(L)n]y+ complexes, where L is a nitrogen-containing ligand, with chemical warfare agent (CWA) simulants in a miniature rectilinear ion trap mass spectrometer were investigated as part of a new approach to detect CWAs. Results show that upon entering the vacuum system via a poly(dimethylsiloxane) (PDMS) membrane introduction, low concentrations of several CWA simulants, including dipropyl sulfide (simulant for mustard gas), acetonitrile (simulant for the nerve agent tabun), and diethyl phosphite (simulant for nerve agents sarin, soman, tabun, and VX), can react with metal complex ions generated by electrospray ionization (ESI), thereby providing a sensitive means of detecting these compounds. The [Ni(L)n]2+ complexes are found to be particularly reactive with the simulants of mustard gas and tabun, allowing their detection at low parts-per-billion (ppb) levels. These detection limits are well below reported exposure limits for these CWAs, which indicates the applicability of this new approach, and are about two orders of magnitude lower than electron ionization detection limits on the same mass spectrometer. The use of coordinatively unsaturated metal complexes as reagent ions offers the possibility of further tuning the ion-molecule chemistry so that desired compounds can be detected selectively or at even lower concentrations.

  7. From energy-rich phosphate compounds to warfare agents: A review on the chemistry of organic phosphate compounds

    Directory of Open Access Journals (Sweden)

    Luciano Albino Giusti


    Full Text Available The chemistry of the phosphorus-oxygen bond is widely used in biological systems in many processes, such as energy transduction and the storage, transmission and expression of genetic information, which are essential to living beings in relation to a wide variety of functions. Compounds containing this bond have been designed for many purposes, ranging from agricultural defense systems, in order to increase food production, to nerve agents, for complaining use in warfare. In this review, features related to the chemistry of organic phosphate compounds are discussed, with particular emphasis on the role of phosphate compounds in biochemical events and in nerve agents. To this aim, the energy-rich phosphate compounds are focused, particularly the mode of their use as energy currency in cells. Historical and recent studies carried out by research groups have tried to elucidate the mechanism of action of enzymes responsible for energy transduction through the use of biochemical studies, enzyme models, and artificial enzymes. Finally, recent studies on the detoxification of nerve agents based on phosphorous esters are presented, and on the utilization of chromogenic and fluorogenic chemosensors for the detection of these phosphate species.

  8. Toxin warfare agents:recognition molecules and drugs for control%生物毒素战剂:检测识别分子与防治药物

    Institute of Scientific and Technical Information of China (English)



    There are various types of toxins in nature. However, these toxins. which are characterized by the ready availability, easy production and high toxicity, are likely biological warfare agents. Toxin warfare agents are different from traditional bacterial and viral agents or from chemical warfare agents in that they pose a great threat because of their diverse potency and the lack of efficacious drugs. Therefore, it is quite important to develop specific. sensitive recognition molecules for detection of toxins and drugs against intoxication caused by toxin agents. This review focuses on advances in recognition molecules of toxins and some drugs used as prevention and treatment hased on the characteristics of toxin warfare agents .%自然界中存在着种类繁多的毒素物质,但最有可能用作战剂的是那些获取方便、制备容易、毒性强、施放后可致人死亡或失能的毒素.毒素战剂既不同于传统的细菌、病毒战剂,也不同于化学毒剂,其最大的威胁来自它的高毒性及缺乏有效的治疗手段.因此,发展毒素战剂的检测识别分子与防治药物就显得尤为重要.本文讨论了生物毒素战剂相关概念、特征,重点综述了毒素战剂的检测识别分子与防治药物研究进展.

  9. Fate of chemical warfare agents and toxic indutrial chemicals in landfills

    DEFF Research Database (Denmark)

    Bartelt-Hunt, D.L.; Barlaz, M.A.; Knappe, D.R.U.


    ) in MSW landfills was predicted with a mathematical model. Five blister agents [sulfur mustard (HD), nitrogen mustard (HN-2), lewisite (L), ethyldichloroarsine (ED), and phosgene oxime (CX)], eight nerve agents [tabun (GA), sarin (GB), soman (GD), GE, GF, VX, VG, and VM], one riot-control agent [CS...

  10. Direct quantification of chemical warfare agents and related compounds at low ppt levels: comparing active capillary dielectric barrier discharge plasma ionization and secondary electrospray ionization mass spectrometry. (United States)

    Wolf, Jan-Christoph; Schaer, Martin; Siegenthaler, Peter; Zenobi, Renato


    A novel active capillary dielectric barrier discharge plasma ionization (DBDI) technique for mass spectrometry is applied to the direct detection of 13 chemical warfare related compounds, including sarin, and compared to secondary electrospray ionization (SESI) in terms of selectivity and sensitivity. The investigated compounds include an intact chemical warfare agent and structurally related molecules, hydrolysis products and/or precursors of highly toxic nerve agents (G-series, V-series, and "new" nerve agents), and blistering and incapacitating warfare agents. Well-defined analyte gas phase concentrations were generated by a pressure-assisted nanospray with consecutive thermal evaporation and dilution. Identification was achieved by selected reaction monitoring (SRM). The most abundant fragment ion intensity of each compound was used for quantification. For DBDI and SESI, absolute gas phase detection limits in the low ppt range (in MS/MS mode) were achieved for all compounds investigated. Although the sensitivity of both methods was comparable, the active capillary DBDI sensitivity was found to be dependent on the applied AC voltage, thus enabling direct tuning of the sensitivity and the in-source fragmentation, which may become a key feature in terms of field applicability. Our findings underline the applicability of DBDI and SESI for the direct, sensitive detection and quantification of several CWA types and their degradation products. Furthermore, they suggest the use of DBDI in combination with hand-held instruments for CWAs on-site monitoring.

  11. Transport behavior of surrogate biological warfare agents in a simulated landfill: Effect of leachate recirculation and water infiltration

    KAUST Repository

    Saikaly, Pascal


    An understanding of the transport behavior of biological warfare (BW) agents in landfills is required to evaluate the suitability of landfills for the disposal of building decontamination residue (BDR) following a bioterrorist attack on a building. Surrogate BW agents, Bacillus atrophaeus spores and Serratia marcescens, were spiked into simulated landfill reactors that were filled with synthetic building debris (SBD) and operated for 4 months with leachate recirculation or water infiltration. Quantitative polymerase chain reaction (Q-PCR) was used to monitor surrogate transport. In the leachate recirculation reactors, <10% of spiked surrogates were eluted in leachate over 4 months. In contrast, 45% and 31% of spiked S. marcescens and B. atrophaeus spores were eluted in leachate in the water infiltration reactors. At the termination of the experiment, the number of retained cells and spores in SBD was measured over the depth of the reactor. Less than 3% of the total spiked S. marcescens cells and no B. atrophaeus spores were detected in SBD. These results suggest that significant fractions of the spiked surrogates were strongly attached to SBD. © 2010 American Chemical Society.

  12. Continuum Model for Decontamination of Chemical Warfare Agent from a Rubbery Polymer using the Maxwell-Stefan Formulation (United States)

    Varady, Mark; Bringuier, Stefan; Pearl, Thomas; Stevenson, Shawn; Mantooth, Brent

    Decontamination of polymers exposed to chemical warfare agents (CWA) often proceeds by application of a liquid solution. Absorption of some decontaminant components proceed concurrently with extraction of the CWA, resulting in multicomponent diffusion in the polymer. In this work, the Maxwell-Stefan equations were used with the Flory-Huggins model of species activity to mathematically describe the transport of two species within a polymer. This model was used to predict the extraction of the nerve agent O-ethyl S-[2(diisopropylamino)ethyl] methylphosphonothioate (VX) from a silicone elastomer into both water and methanol. Comparisons with experimental results show good agreement with minimal fitting of model parameters from pure component uptake data. Reaction of the extracted VX with sodium hydroxide in the liquid-phase was also modeled and used to predict the overall rate of destruction of VX. Although the reaction proceeds more slowly in the methanol-based solution compared to the aqueous solution, the extraction rate is faster due to increasing VX mobility as methanol absorbs into the silicone, resulting in an overall faster rate of VX destruction.

  13. Semi-continuous high speed gas analysis of generated vapors of chemical warfare agents

    NARCIS (Netherlands)

    Trap, H.C.; Langenberg, J.P.


    A method is presented for the continuous analysis of generated vapors of the nerve agents soman and satin and the blistering agent sulfur mustard. By using a gas sampling valve and a very short (15 cm) column connected to an on-column injector with a 'standard length' column, the system can either

  14. The application of single particle aerosol mass spectrometry for the detection and identification of high explosives and chemical warfare agents

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Audrey Noreen [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)


    Single Particle Aerosol Mass Spectrometry (SPAMS) was evaluated as a real-time detection technique for single particles of high explosives. Dual-polarity time-of-flight mass spectra were obtained for samples of 2,4,6-trinitrotoluene (TNT), 1,3,5-trinitro-1,3,5-triazinane (RDX), and pentaerythritol tetranitrate (PETN); peaks indicative of each compound were identified. Composite explosives, Comp B, Semtex 1A, and Semtex 1H were also analyzed, and peaks due to the explosive components of each sample were present in each spectrum. Mass spectral variability with laser fluence is discussed. The ability of the SPAMS system to identify explosive components in a single complex explosive particle (~1 pg) without the need for consumables is demonstrated. SPAMS was also applied to the detection of Chemical Warfare Agent (CWA) simulants in the liquid and vapor phases. Liquid simulants for sarin, cyclosarin, tabun, and VX were analyzed; peaks indicative of each simulant were identified. Vapor phase CWA simulants were adsorbed onto alumina, silica, Zeolite, activated carbon, and metal powders which were directly analyzed using SPAMS. The use of metal powders as adsorbent materials was especially useful in the analysis of triethyl phosphate (TEP), a VX stimulant, which was undetectable using SPAMS in the liquid phase. The capability of SPAMS to detect high explosives and CWA simulants using one set of operational conditions is established.

  15. Decomposition of 2-chloroethylethylsulfide on copper oxides to detoxify polymer-based spherical activated carbons from chemical warfare agents. (United States)

    Fichtner, S; Hofmann, J; Möller, A; Schrage, C; Giebelhausen, J M; Böhringer, B; Gläser, R


    For the decomposition of chemical warfare agents, a hybrid material concept was applied. This consists of a copper oxide-containing phase as a component with reactive functionality supported on polymer-based spherical activated carbon (PBSAC) as a component with adsorptive functionality. A corresponding hybrid material was prepared by impregnation of PBSAC with copper(II)nitrate and subsequent calcination at 673K. The copper phase exists predominantly as copper(I)oxide which is homogeneously distributed over the PBSAC particles. The hybrid material containing 16 wt.% copper on PBSAC is capable of self-detoxifying the mustard gas surrogate 2-chloroethylethylsulfide (CEES) at room temperature. The decomposition is related to the breakthrough behavior of the reactant CEES, which displaces the reaction product ethylvinylsulfide (EVS). This leads to a combined breakthrough of CEES and EVS. The decomposition of CEES is shown to occur catalytically over the copper-containing PBSAC material. Thus, the hybrid material can even be considered to be self-cleaning.

  16. Facility monitoring of chemical warfare agent simulants in air using an automated, field-deployable, miniature mass spectrometer. (United States)

    Smith, Jonell N; Noll, Robert J; Cooks, R Graham


    Vapors of four chemical warfare agent (CWA) stimulants, 2-chloroethyl ethyl sulfide (CEES), diethyl malonate (DEM), dimethyl methylphosphonate (DMMP), and methyl salicylate (MeS), were detected, identified, and quantitated using a fully automated, field-deployable, miniature mass spectrometer. Samples were ionized using a glow discharge electron ionization (GDEI) source, and ions were mass analyzed with a cylindrical ion trap (CIT) mass analyzer. A dual-tube thermal desorption system was used to trap compounds on 50:50 Tenax TA/Carboxen 569 sorbent before their thermal release. The sample concentrations ranged from low parts per billion [ppb] to two parts per million [ppm]. Limits of detection (LODs) ranged from 0.26 to 5.0 ppb. Receiver operating characteristic (ROC) curves are presented for each analyte. A sample of CEES at low ppb concentration was combined separately with two interferents, bleach (saturated vapor) and diesel fuel exhaust (1%), as a way to explore the capability of detecting the simulant in an environmental matrix. Also investigated was a mixture of the four CWA simulants (at concentrations in air ranging from 270 to 380 ppb). Tandem mass (MS/MS) spectral data were used to identify and quantify the individual components. Copyright © 2011 John Wiley & Sons, Ltd.

  17. Express analysis of explosives, chemical warfare agents and drugs with multicapillary column gas chromatography and ion mobility increment spectrometry. (United States)

    Buryakov, Igor A


    Description of a gas chromatograph designed for express analysis of explosives (2,4-dinitrotoluene, 2,4,6-trinitrotoluene, pentaerythritol tetranitrate), chemical warfare agents (mustard gas, lewisite, sarin) and drugs (heroin, cocaine hydrochloride, crack) is given. The devices comprises a multicapillary chromatographic column and an ion mobility increment spectrometer (MCC-IMIS). The main analytical characteristics of an IMIS (estimated detection limit (DL), linear dynamic range (LDR), speed of response) and a chromatographic column (separation power, degree of separation, a number of possible peaks at a chromatogram section, divided by analysis time) are determined. The maximum value of DL equal to 5 pg/ml was registered for cis-alpha-LW, and the lowest one of 0.001 pg/ml was for cocaine. The maximum value of LDR equal to 1000 was registered for sarin and the lowest one of 150 was for the ions of lewisite. Speed of response of one compound detection with the IMIS was 0.7 s.

  18. Detection of chemical warfare agent-related phenylarsenic compounds in marine biota samples by LC-HESI/MS/MS. (United States)

    Niemikoski, Hanna; Soderstrom, Martin; Vanninen, Paula


    A new method has been developed to determine oxidation products of three chemical warfare agent (CWA) related phenylarsenic compounds from marine biota samples by a liquid chromatography-heated electrospray ioniza-tion/tandem mass spectrometry (LC-HESI/MS/MS). The target chemicals were oxidation products of Adamsite (DM[ox]), Clark I (DA[ox]), and triphenylarsine (TPA[ox]). Method was validated within the concentration range of 1-5 ng/g, 0.2-5 ng/g and 0.2-5 ng/g for DM[ox], DA[ox] and TPA[ox], respectively. The method was linear, precise and accurate. Limits of quantification (LOQ) were 2.0, 1.3 and 2.1 ng/g for DM[ox], DA[ox] and TPA[ox], respectively. A total of ten fish samples and one lobster sample collected from near Swedish coast, Måseskär dumpsite were analysed. Trace concentrations below LOQ values were detected in three samples and the elemental composition of oxidized form of Clark I and /or II was con-firmed by LC-HESI/HRMS. To our knowledge, this is the first study that provides the presence of CWA related chemicals in marine biota samples.

  19. Facile hydrolysis-based chemical destruction of the warfare agents VX, GB, and HD by alumina-supported fluoride reagents. (United States)

    Gershonov, E; Columbus, I; Zafrani, Y


    A facile solvent-free hydrolysis (chemical destruction) of the warfare agents VX (O-ethyl S-2-(diisopropylamino)ethyl methylphosphonothioate), GB (O-isopropyl methylphosphonofluoridate or sarin), and HD (2,2'-dichloroethyl sulfide or sulfur mustard) upon reaction with various solid-supported fluoride reagents is described. These solid reagents include different alumina-based powders such as KF/Al(2)O(3), AgF/KF/Al(2)O(3), and KF/Al(2)O(3) enriched by so-called coordinatively unsaturated fluoride ions (termed by us as ECUF-KF/Al(2)O(3)). When adsorbed on these sorbents, the nerve agent VX quickly hydrolyzed (t(1/2) range between 0.1-6.3 h) to the corresponding nontoxic phosphonic acid EMPA as a major product (>90%) and to the relatively toxic desethyl-VX (<10%). The latter byproduct was further hydrolyzed to the nontoxic MPA product (t(1/2) range between 2.2-161 h). The reaction rates and the product distribution were found to be strongly dependent on the nature of the fluoride ions in the KF/Al(2)O(3) matrix and on its water content. All variations of the alumina-supported fluoride reagents studied caused an immediate hydrolysis of the highly toxic GB (t(1/2) < 10 min) to form the corresponding nontoxic phosphonic acid IMPA. A preliminary study of the detoxification of HD on these catalyst supports showed the formation of the nontoxic 1,4-thioxane as a major product together with minor amounts of TDG and vinylic compounds within a few days. The mechanisms and the efficiency of these processes were successfully studied by solid-state (31)P, (13)C, and (19)F MAS NMR.

  20. Cyberspace as a Complex Adaptive System and the Policy and Operational Implications for Cyber Warfare (United States)


    accessed 13 February 2014). 66Teresa Degenhard “Between War and Crime: The Overlap between War and Crime: Unpacking Foucault and Agamben’s Studies...Article-2-Revision- for- Foucault -and-Agamben-Degenhardt-July-2013.pdf (accessed 5 April 2014). 26... Foucault and Agamben’s Studies within the Context of the War on Terror.”, 34. 68US Department of Defense, Electronic Warfare, Joint Publication 3-13, I-2

  1. Autonomous-agent based simulation of anti-submarine warfare operations with the goal of protecting a high value unit


    Akbori, Fahrettin


    Approved for public release, distribution unlimited The Anti-Submarine Warfare screen design simulation is a program that provides a model for operations in anti-submarine warfare (ASW). The purpose of the program is to aid ASW commanders, allowing them to configure an ASW screen, including the sonar policy, convoy speed, and the number of ships, to gain insight into how these and other factors beyond their control, such as water conditions, impact ASW effectiveness. It is also designed to...

  2. Chicken cathelicidin-2-derived peptides with enhanced immunomodulatory and antibacterial activities against biological warfare agents

    NARCIS (Netherlands)

    Molhoek, E.M.; van Dijk, A.; Veldhuizen, E.J.A.; Dijk-Knijnenburg, H.; Mars-Groenendijk, R.H.; Boele, L.C.L.; Kaman, W.E.; Haagsman, H.P.; Bikker, F.J.


    Host defence peptides (HDPs) are considered to be excellent candidates for the development of novel therapeutic agents. Recently, it was demonstrated that the peptide C1-15, an N-terminal segment of chicken HDP cathelicidin-2, exhibits potent antibacterial activity while lacking cytotoxicity towards

  3. Chicken cathelicidin-2-derived peptides with enhanced immunomodulatory and antibacterial activities against biological warfare agents

    NARCIS (Netherlands)

    Molhoek, E.M.; Dijk, A. van; Veldhuizen, E.J.A.; Dijk-Knijnenburg, H.; Mars-Groenendijk, R.H.; Boele, L.C.L.; Kaman-van Zanten, W.E.; Haagsman, H.P.; Bikker, F.J.


    Host defence peptides (HDPs) are considered to be excellent candidates for the development of novel therapeutic agents. Recently, it was demonstrated that the peptide C1-15, an N-terminal segment of chicken HDP cathelicidin-2, exhibits potent antibacterial activity while lacking cytotoxicity towards

  4. Enzymatic Neutralization of the Chemical Warfare Agent VX: Evolution of Phosphotriesterase for Phosphorothiolate Hydrolysis


    Bigley, Andrew N.; Xu, Chengfu; Henderson, Terry J.; Steven P. Harvey; Raushel, Frank M.


    The V-type nerve agents (VX and VR) are among the most toxic substances known. The high toxicity and environmental persistence of VX makes the development of novel decontamination methods particularly important. The enzyme phosphotriesterase (PTE) is capable of hydrolyzing VX but with an enzymatic efficiency more than 5-orders of magnitude lower than with its best substrate, paraoxon. PTE has previously proven amenable to directed evolution for the improvement of catalytic activity against se...

  5. Ion mobility spectrometric analysis of vaporous chemical warfare agents by the instrument with corona discharge ionization ammonia dopant ambient temperature operation. (United States)

    Satoh, Takafumi; Kishi, Shintaro; Nagashima, Hisayuki; Tachikawa, Masumi; Kanamori-Kataoka, Mieko; Nakagawa, Takao; Kitagawa, Nobuyoshi; Tokita, Kenichi; Yamamoto, Soichiro; Seto, Yasuo


    The ion mobility behavior of nineteen chemical warfare agents (7 nerve gases, 5 blister agents, 2 lachrymators, 2 blood agents, 3 choking agents) and related compounds including simulants (8 agents) and organic solvents (39) was comparably investigated by the ion mobility spectrometry instrument utilizing weak electric field linear drift tube with corona discharge ionization, ammonia doping, purified inner air drift flow circulation operated at ambient temperature and pressure. Three alkyl methylphosphonofluoridates, tabun, and four organophosphorus simulants gave the intense characteristic positive monomer-derived ion peaks and small dimer-derived ion peaks, and the later ion peaks were increased with the vapor concentrations. VX, RVX and tabun gave both characteristic positive monomer-derived ions and degradation product ions. Nitrogen mustards gave the intense characteristic positive ion peaks, and in addition distinctive negative ion peak appeared from HN3. Mustard gas, lewisite 1, o-chlorobenzylidenemalononitrile and 2-mercaptoethanol gave the characteristic negative ion peaks. Methylphosphonyl difluoride, 2-chloroacetophenone and 1,4-thioxane gave the characteristic ion peaks both in the positive and negative ion mode. 2-Chloroethylethylsulfide and allylisothiocyanate gave weak ion peaks. The marker ion peaks derived from two blood agents and three choking agents were very close to the reactant ion peak in negative ion mode and the respective reduced ion mobility was fluctuated. The reduced ion mobility of the CWA monomer-derived peaks were positively correlated with molecular masses among structurally similar agents such as G-type nerve gases and organophosphorus simulants; V-type nerve gases and nitrogen mustards. The slope values of the calibration plots of the peak heights of the characteristic marker ions versus the vapor concentrations are related to the detection sensitivity, and within chemical warfare agents examined the slope values for sarin, soman

  6. Enzymatic neutralization of the chemical warfare agent VX: evolution of phosphotriesterase for phosphorothiolate hydrolysis. (United States)

    Bigley, Andrew N; Xu, Chengfu; Henderson, Terry J; Harvey, Steven P; Raushel, Frank M


    The V-type nerve agents (VX and VR) are among the most toxic substances known. The high toxicity and environmental persistence of VX make the development of novel decontamination methods particularly important. The enzyme phosphotriesterase (PTE) is capable of hydrolyzing VX but with an enzymatic efficiency more than 5 orders of magnitude lower than with its best substrate, paraoxon. PTE has previously proven amenable to directed evolution for the improvement of catalytic activity against selected compounds through the manipulation of active-site residues. Here, a series of sequential two-site mutational libraries encompassing 12 active-site residues of PTE was created. The libraries were screened for catalytic activity against a new VX analogue, DEVX, which contains the same thiolate leaving group of VX coupled to a diethoxyphosphate core rather than the ethoxymethylphosphonate core of VX. The evolved catalytic activity with DEVX was enhanced 26-fold relative to wild-type PTE. Further improvements were facilitated by targeted error-prone PCR mutagenesis of loop-7, and additional PTE variants were identified with up to a 78-fold increase in the rate of DEVX hydrolysis. The best mutant hydrolyzed the racemic nerve agent VX with a value of kcat/Km = 7 × 10(4) M(-1) s(-1), a 230-fold improvement relative to wild-type PTE. The highest turnover number achieved by the mutants created for this investigation was 137 s(-1), an enhancement of 152-fold relative to wild-type PTE. The stereoselectivity for the hydrolysis of the two enantiomers of VX was relatively low. These engineered mutants of PTE are the best catalysts ever reported for the hydrolysis of nerve agent VX.

  7. Status of miniature integrated UV resonance fluorescence and Raman sensors for detection and identification of biochemical warfare agents (United States)

    Hug, William F.; Bhartia, Rohit; Taspin, Alexandre; Lane, Arthur; Conrad, Pamela; Sijapati, Kripa; Reid, Ray D.


    Laser induced native fluorescence (LINF) is the most sensitive method of detection of biological material including microorganisms, virus', and cellular residues. LINF is also a sensitive method of detection for many non-biological materials as well. The specificity with which these materials can be classified depends on the excitation wavelength and the number and location of observation wavelengths. Higher levels of specificity can be obtained using Raman spectroscopy but a much lower levels of sensitivity. Raman spectroscopy has traditionally been employed in the IR to avoid fluorescence. Fluorescence rarely occurs at wavelength below about 270nm. Therefore, when excitation occurs at a wavelength below 250nm, no fluorescence background occurs within the Raman fingerprint region for biological materials. When excitation occurs within electronic resonance bands of the biological target materials, Raman signal enhancement over one million typically occurs. Raman sensitivity within several hundred times fluorescence are possible in the deep UV where most biological materials have strong absorption. Since the Raman and fluorescence emissions occur at different wavelength, both spectra can be observed simultaneously, thereby providing a sensor with unique sensitivity and specificity capability. We will present data on our integrated, deep ultraviolet, LINF/Raman instruments that are being developed for several applications including life detection on Mars as well as biochemical warfare agents on Earth. We will demonstrate the ability to discriminate organic materials based on LINF alone. Together with UV resonance Raman, higher levels of specificity will be demonstrated. In addition, these instruments are being developed as on-line chemical sensors for industrial and municipal waste streams and product quality applications.

  8. Handheld and mobile hyperspectral imaging sensors for wide-area standoff detection of explosives and chemical warfare agents (United States)

    Gomer, Nathaniel R.; Gardner, Charles W.; Nelson, Matthew P.


    Hyperspectral imaging (HSI) is a valuable tool for the investigation and analysis of targets in complex background with a high degree of autonomy. HSI is beneficial for the detection of threat materials on environmental surfaces, where the concentration of the target of interest is often very low and is typically found within complex scenery. Two HSI techniques that have proven to be valuable are Raman and shortwave infrared (SWIR) HSI. Unfortunately, current generation HSI systems have numerous size, weight, and power (SWaP) limitations that make their potential integration onto a handheld or field portable platform difficult. The systems that are field-portable do so by sacrificing system performance, typically by providing an inefficient area search rate, requiring close proximity to the target for screening, and/or eliminating the potential to conduct real-time measurements. To address these shortcomings, ChemImage Sensor Systems (CISS) is developing a variety of wide-field hyperspectral imaging systems. Raman HSI sensors are being developed to overcome two obstacles present in standard Raman detection systems: slow area search rate (due to small laser spot sizes) and lack of eye-safety. SWIR HSI sensors have been integrated into mobile, robot based platforms and handheld variants for the detection of explosives and chemical warfare agents (CWAs). In addition, the fusion of these two technologies into a single system has shown the feasibility of using both techniques concurrently to provide higher probability of detection and lower false alarm rates. This paper will provide background on Raman and SWIR HSI, discuss the applications for these techniques, and provide an overview of novel CISS HSI sensors focused on sensor design and detection results.

  9. Real-time, wide-area hyperspectral imaging sensors for standoff detection of explosives and chemical warfare agents (United States)

    Gomer, Nathaniel R.; Tazik, Shawna; Gardner, Charles W.; Nelson, Matthew P.


    Hyperspectral imaging (HSI) is a valuable tool for the detection and analysis of targets located within complex backgrounds. HSI can detect threat materials on environmental surfaces, where the concentration of the target of interest is often very low and is typically found within complex scenery. Unfortunately, current generation HSI systems have size, weight, and power limitations that prohibit their use for field-portable and/or real-time applications. Current generation systems commonly provide an inefficient area search rate, require close proximity to the target for screening, and/or are not capable of making real-time measurements. ChemImage Sensor Systems (CISS) is developing a variety of real-time, wide-field hyperspectral imaging systems that utilize shortwave infrared (SWIR) absorption and Raman spectroscopy. SWIR HSI sensors provide wide-area imagery with at or near real time detection speeds. Raman HSI sensors are being developed to overcome two obstacles present in standard Raman detection systems: slow area search rate (due to small laser spot sizes) and lack of eye-safety. SWIR HSI sensors have been integrated into mobile, robot based platforms and handheld variants for the detection of explosives and chemical warfare agents (CWAs). In addition, the fusion of these two technologies into a single system has shown the feasibility of using both techniques concurrently to provide higher probability of detection and lower false alarm rates. This paper will provide background on Raman and SWIR HSI, discuss the applications for these techniques, and provide an overview of novel CISS HSI sensors focusing on sensor design and detection results.

  10. Heme-Containing Metal-Organic Frameworks for the Oxidative Degradation of Chemical Warfare Agents (United States)


    reflectance UV / visible spectroscopy illustrating the reaction of PCNF2-224 (blue trace) with O3 at −40 °C to from PCNF2-224FeIVO (red trace). Figure 6...PI: T. David Harris results in the formation of new species with a distinct UV / Visible spectrum, consistent with the formation of the...solution of THF and an excess of the strong reducing agent, NaC10H8 results in a UV / Visible spectrum distinct from both the ferrous state and the one

  11. Decontamination of Chemical/Biological Warfare (CBW) Agents Using an Atmospheric Pressure Plasma Jet (APPJ) (United States)

    Herrmann, Hans W.


    The atmospheric pressure plasma jet (APPJ) is a non-thermal, high pressure, uniform glow discharge that produces a high velocity effluent stream of highly reactive chemical species. The discharge operates on a feedstock gas (e.g. He/O_2/H_2O) which flows between an outer, grounded, cylindrical electrode and an inner, coaxial electrode powered at 13.56 MHz RF. While passing through the plasma, the feedgas becomes excited, dissociated or ionized by electron impact. Once the gas exits the discharge volume, ions and electrons are rapidly lost by recombination, but the fast-flowing effluent still contains metastables (e.g. O2*, He*) and radicals (e.g. O, OH). These reactive species have been shown to be effective neutralizers of surrogates for anthrax spores, mustard blister agent and VX nerve gas. Unlike conventional, wet decontamination methods, the plasma effluent does not cause corrosion of most surfaces and does not damage wiring, electronics, nor most plastics. This makes it highly suitable for decontamination of high value sensitive equipment such as is found in vehicle interiors (i.e. tanks, planes...) for which there is currently no good decontamination technique. Furthermore, the reactive species rapidly degrade into harmless products leaving no lingering residue or harmful byproducts. Physics of the APPJ will be discussed and results of surface decontamination experiments using simulant and actual CBW agents will be presented.

  12. Cerium oxide for the destruction of chemical warfare agents: A comparison of synthetic routes

    Energy Technology Data Exchange (ETDEWEB)

    Janoš, Pavel, E-mail: [Faculty of the Environment, University of Jan Evangelista Purkyně, Králova Výšina 7, 400 96 Ústí nad Labem (Czech Republic); Henych, Jiří [Faculty of the Environment, University of Jan Evangelista Purkyně, Králova Výšina 7, 400 96 Ústí nad Labem (Czech Republic); Institute of Inorganic Chemistry AS CR v.v.i., 25068 Řež (Czech Republic); Pelant, Ondřej; Pilařová, Věra; Vrtoch, Luboš [Faculty of the Environment, University of Jan Evangelista Purkyně, Králova Výšina 7, 400 96 Ústí nad Labem (Czech Republic); Kormunda, Martin [Faculty of Sciences, University of Jan Evangelista Purkyně, České Mládeže 8, 400 96 Ústí nad Labem (Czech Republic); Mazanec, Karel [Military Research Institute, Veslařská 230, 637 00 Brno (Czech Republic); and others


    Highlights: • Four synthetic routes were compared to prepare the nanoceria-based reactive sorbents. • The sorbents prepared by homogeneous hydrolysis destroy efficiently the soman and VX nerve agents. • Toxic organophosphates are converted to less-dangerous products completely within a few minutes. • Surface non-stoichiometry and −OH groups promote the destruction by the S{sub N}2 mechanism. - Abstract: Four different synthetic routes were used to prepare active forms of cerium oxide that are capable of destroying toxic organophosphates: a sol–gel process (via a citrate precursor), homogeneous hydrolysis and a precipitation/calcination procedure (via carbonate and oxalate precursors). The samples prepared via homogeneous hydrolysis with urea and the samples prepared via precipitation with ammonium bicarbonate (with subsequent calcination at 500 °C in both cases) exhibited the highest degradation efficiencies towards the extremely dangerous nerve agents soman (O-pinacolyl methylphosphonofluoridate) and VX (O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate) and the organophosphate pesticide parathion methyl. These samples were able to destroy more than 90% of the toxic compounds in less than 10 min. The high degradation efficiency of cerium oxide is related to its complex surface chemistry (presence of surface −OH groups and surface non-stoichiometry) and to its nanocrystalline nature, which promotes the formation of crystal defects on which the decomposition of organophosphates proceeds through a nucleophilic substitution mechanism that is not dissimilar to the mechanism of enzymatic hydrolysis of organic phosphates by phosphotriesterase.

  13. Environmental toxicity of Chemical Warfare Agents (CWAs) - MicrotoxTM and Spontaneous Locomotor Changes

    DEFF Research Database (Denmark)

    Storgaard, Morten Swayne; Sanderson, Hans; Baatrup, Erik

    After the 2nd World War the CWAs were prohibited by law and 11,000 tonnes of toxic agents were dumped in the Bornholm Basin east of Bornholm. The dumped chemical munitions have not reached attention from politicians and scientists until recently. During earlier projects, such as MERCW (2005...... to be illuminated in which this study hopefully will contribute to. Especially, chronic toxicity needs to be described as this mimics a more environmentally realistic situation. One or two compounds will be accessed based upon various factors such as detection frequencies, found concentrations in both sediment...... to the commercially important cod (Gadus morrhua). The cod migrates down to the seafloor – even crossing the oxycline - where the CWA munitions were dumped. To sum up, this study will obtain novel ecotoxicity data on recently discovered degradation products and assess the potential threat to the commercially...

  14. Variants of Phosphotriesterase for the Enhanced Detoxification of the Chemical Warfare Agent VR. (United States)

    Bigley, Andrew N; Mabanglo, Mark F; Harvey, Steven P; Raushel, Frank M


    The V-type organophosphorus nerve agents are among the most hazardous compounds known. Previous efforts to evolve the bacterial enzyme phosphotriesterase (PTE) for the hydrolytic decontamination of VX resulted in the identification of the variant L7ep-3a, which has a kcat value more than 2 orders of magnitude higher than that of wild-type PTE for the hydrolysis of VX. Because of the relatively small size of the O-ethyl, methylphosphonate center in VX, stereoselectivity is not a major concern. However, the Russian V-agent, VR, contains a larger O-isobutyl, methylphosphonate center, making stereoselectivity a significant issue since the SP-enantiomer is expected to be significantly more toxic than the RP-enantiomer. The three-dimensional structure of the L7ep-3a variant was determined to a resolution of 2.01 Å (PDB id: 4ZST ). The active site of the L7ep-3a mutant has revealed a network of hydrogen bonding interactions between Asp-301, Tyr-257, Gln-254, and the hydroxide that bridges the two metal ions. A series of new analogues that mimic VX and VR has helped to identify critical structural features for the development of new enzyme variants that are further enhanced for the catalytic detoxification of VR and VX. The best of these mutants has been shown to have a reversed stereochemical preference for the hydrolysis of VR-chiral center analogues. This mutant hydrolyzes the two enantiomers of VR 160- and 600-fold faster than wild-type PTE hydrolyzes the SP-enantiomer of VR.

  15. Decontamination of chemical warfare sulfur mustard agent simulant by ZnO nanoparticles (United States)

    Sadeghi, Meysam; Yekta, Sina; Ghaedi, Hamed


    In this study, zinc oxide nanoparticles (ZnO NPs) have been surveyed to decontaminate the chloroethyl phenyl sulfide as a sulfur mustard agent simulant. Prior to the reaction, ZnO NPs were successfully prepared through sol-gel method in the absence and presence of polyvinyl alcohol (PVA). PVA was utilized as a capping agent to control the agglomeration of the nanoparticles. The formation, morphology, elemental component, and crystalline size of nanoscale ZnO were certified and characterized by SEM/EDX, XRD, and FT-IR techniques. The decontamination (adsorption and destruction) was tracked by the GC-FID analysis, in which the effects of polarity of the media, such as isopropanol, acetone and n-hexane, reaction time intervals from 1 up to 18 h, and different temperatures, including 25, 35, 45, and 55 °C, on the catalytic/decontaminative capability of the surface of ZnO NPs/PVA were investigated and discussed, respectively. Results demonstrated that maximum decontamination (100 %) occurred in n-hexane solvent at 55 °C after 1 h. On the other hand, the obtained results for the acetone and isopropanol solvents were lower than expected. GC-MS chromatograms confirmed the formation of hydroxyl ethyl phenyl sulfide and phenyl vinyl sulfide as the destruction reaction products. Furthermore, these chromatograms proved the role of hydrolysis and elimination mechanisms on the catalyst considering its surface Bronsted and Lewis acid sites. A non-polar solvent aids material transfer to the reactive surface acid sites without blocking these sites.

  16. Distinct human antibody response to the biological warfare agent Burkholderia mallei. (United States)

    Varga, John J; Vigil, Adam; DeShazer, David; Waag, David M; Felgner, Philip; Goldberg, Joanna B


    The genetic similarity between Burkholderia mallei (glanders) and Burkholderia pseudomallei (melioidosis) had led to the general assumption that pathogenesis of each bacterium would be similar. In 2000, the first human case of glanders in North America since 1945 was reported in a microbiology laboratory worker. Leveraging the availability of pre-exposure sera for this individual and employing the same well-characterized protein array platform that has been previously used to study a large cohort of melioidosis patients in southeast Asia, we describe the antibody response in a human with glanders. Analysis of 156 peptides present on the array revealed antibodies against 17 peptides with a > 2-fold increase in this infection. Unexpectedly, when the glanders data were compared with a previous data set from B. pseudomallei infections, there were only two highly increased antibodies shared between these two infections. These findings have implications in the diagnosis and treatment of B. mallei and B. pseudomallei infections.

  17. Implications for studying team cognition and team performance in network-centric warfare paradigms. (United States)

    Krueger, Gerald P; Banderet, Louis E


    Network-centric warfare's (NCW) information-rich systems involving sophisticated sensors, tracking systems, smart weapons, and enhanced digital communications threaten to overload combatants with voluminous amounts of data. It is unclear whether warfighters will perceive such extensive data as actionable information to which they will respond accurately in a timely enough manner. Members of small teams in command and control centers, operating in crew-served vehicles, or simply "grunting it out" as ground-pounding infantrymen, may be disparately separated by space, but will communicate and be connected by electronic linkages, e.g., radio, text messages, situation displays, or global positioning data. However, team members will also have to remember shared mental models of tasks at hand, pay attention to and share common situation awareness in complex operational environments, perform team cognition and team coordination, and integrate both lower and higher cognitive processes with those of team behaviors. Such exceptional capabilities are required more now than ever before; such capabilities today are far from assured. After two workshops to establish performance metrics for assessing cognitive performance of military personnel in NCW, this preface introduces five manuscripts addressing team cognition and team performance from both a theoretical and a practical perspective. The authors of this preface question if NCW, and perhaps the politico-social ramifications of modern warfare, have already outstripped behavioral scientists' approach to researching team cognition and team performance-expertise that is so crucially needed for combatants on the rapidly changing 21st-century battlegrounds.

  18. Capillary zone electrophoresis analysis and detection of mid-spectrum biological warfare agents

    Energy Technology Data Exchange (ETDEWEB)

    Boulet, C.A.; Townsley, C.


    DRE Suffield has initiated a research program to develop methods and equipment for field detection and laboratory identification of mid-spectrum agents, molecules of biological origin such as proteins, peptides and toxins. In this study, a highly efficient and reproducible capillary zone electrophoresis method was developed to separate and identify a series of nine peptides of defence interest: bradykinin, bradykinin fragment 1-5, substance P,ARG8-vasopressin, luteinizing hormone releasing hormone, bombesin, leucine enkephalin, methionine enkephalin, and oxytocin. Using a 50 micrometer x 47 cm capillary column, 22.5 kV separation voltage and a 100 mM pH 2.5 phosphate buffer, all nine peptide could separated in under 10 minutes. Three strategies, which could be used in a fully automated field detection and identification system, were demonstrated for the identification of unknown peptides: comparison of migration times, comparison of electrophoretic mobilities, and co-injection of multiple reference standards. These experiments demonstrate that a separation based analytical method such as capillary electrophoresis could form the basis of a generic detection system for mid-spectrum protein and peptide toxins.

  19. Chemical analysis of bleach and hydroxide-based solutions after decontamination of the chemical warfare agent O-ethyl S-2-diisopropylaminoethyl methylphosphonothiolate (VX). (United States)

    Hopkins, F B; Gravett, M R; Self, A J; Wang, M; Chua, Hoe-Chee; Hoe-Chee, C; Lee, H S Nancy; Sim, N Lee Hoi; Jones, J T A; Timperley, C M; Riches, J R


    Detailed chemical analysis of solutions used to decontaminate chemical warfare agents can be used to support verification and forensic attribution. Decontamination solutions are amongst the most difficult matrices for chemical analysis because of their corrosive and potentially emulsion-based nature. Consequently, there are relatively few publications that report their detailed chemical analysis. This paper describes the application of modern analytical techniques to the analysis of decontamination solutions following decontamination of the chemical warfare agent O-ethyl S-2-diisopropylaminoethyl methylphosphonothiolate (VX). We confirm the formation of N,N-diisopropylformamide and N,N-diisopropylamine following decontamination of VX with hypochlorite-based solution, whereas they were not detected in extracts of hydroxide-based decontamination solutions by nuclear magnetic resonance (NMR) spectroscopy or gas chromatography-mass spectrometry. We report the electron ionisation and chemical ionisation mass spectroscopic details, retention indices, and NMR spectra of N,N-diisopropylformamide and N,N-diisopropylamine, as well as analytical methods suitable for their analysis and identification in solvent extracts and decontamination residues.

  20. The ethics of information warfare

    CERN Document Server

    Floridi, Luciano


    This book offers an overview of the ethical problems posed by Information Warfare, and of the different approaches and methods used to solve them, in order to provide the reader with a better grasp of the ethical conundrums posed by this new form of warfare.The volume is divided into three parts, each comprising four chapters. The first part focuses on issues pertaining to the concept of Information Warfare and the clarifications that need to be made in order to address its ethical implications. The second part collects contributions focusing on Just War Theory and its application to the case of Information Warfare. The third part adopts alternative approaches to Just War Theory for analysing the ethical implications of this phenomenon. Finally, an afterword by Neelie Kroes - Vice President of the European Commission and European Digital Agenda Commissioner - concludes the volume. Her contribution describes the interests and commitments of the European Digital Agenda with respect to research for the developme...

  1. Detection of aqueous phase chemical warfare agent degradation products by negative mode ion mobility time-of-flight mass spectrometry [IM(tof)MS]. (United States)

    Steiner, Wes E; Harden, Charles S; Hong, Feng; Klopsch, Steve J; Hill, Herbert H; McHugh, Vincent M


    The use of negative ion monitoring mode with an atmospheric pressure ion mobility orthogonal reflector time-of-flight mass spectrometer [IM(tof)MS] to detect chemical warfare agent (CWA) degradation products from aqueous phase samples has been determined. Aqueous phase sampling used a traditional electrospray ionization (ESI) source for sample introduction and ionization. Certified reference materials (CRM) of CWA degradation products for the detection of Schedule 1, 2, or 3 toxic chemicals or their precursors as defined by the chemical warfare convention (CWC) treaty verification were used in this study. A mixture of six G-series nerve related CWA degradation products (EMPA, IMPA, EHEP, IHEP, CHMPA, and PMPA) and their related collision induced dissociation (CID) fragment ions (MPA and EPA) were found in each case to be clearly resolved and detected using the IM(tof)MS instrument in negative ion monitoring mode. Corresponding ions, masses, drift times, K(o) values, and signal intensities for each of the CWA degradation products are reported.

  2. Development of haemostatic decontaminants for treatment of wounds contaminated with chemical warfare agents. 3: Evaluation of in vitro topical decontamination efficacy using damaged skin. (United States)

    Lydon, Helen L; Hall, Charlotte A; Dalton, Christopher H; Chipman, J Kevin; Graham, John S; Chilcott, Robert P


    Previous studies have demonstrated that haemostatic products with an absorptive mechanism of action retain their clotting efficiency in the presence of toxic materials and are effective in decontaminating chemical warfare (CW) agents when applied to normal, intact skin. The purpose of this in vitro study was to assess three candidate haemostatic products for effectiveness in the decontamination of superficially damaged porcine skin exposed to the radiolabelled CW agents, soman (GD), VX and sulphur mustard (HD). Controlled physical damage (removal of the upper 100 μm skin layer) resulted in a significant enhancement of the dermal absorption of all three CW agents. Of the haemostatic products assessed, WoundStat™ was consistently the most effective, being equivalent in performance to a standard military decontaminant (fuller's earth). These data suggest that judicious application of haemostatic products to wounds contaminated with CW agents may be a viable option for the clinical management of casualties presenting with contaminated, haemorrhaging injuries. Further studies using a relevant animal model are required to confirm the potential clinical efficacy of WoundStat™ for treating wounds contaminated with CW agents. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  3. Graphene oxide as sensitive layer in Love-wave surface acoustic wave sensors for the detection of chemical warfare agent simulants. (United States)

    Sayago, Isabel; Matatagui, Daniel; Fernández, María Jesús; Fontecha, José Luis; Jurewicz, Izabela; Garriga, Rosa; Muñoz, Edgar


    A Love-wave device with graphene oxide (GO) as sensitive layer has been developed for the detection of chemical warfare agent (CWA) simulants. Sensitive films were fabricated by airbrushing GO dispersions onto Love-wave devices. The resulting Love-wave sensors detected very low CWA simulant concentrations in synthetic air at room temperature (as low as 0.2 ppm for dimethyl-methylphosphonate, DMMP, a simulant of sarin nerve gas, and 0.75 ppm for dipropylene glycol monomethyl ether, DPGME, a simulant of nitrogen mustard). High responses to DMMP and DPGME were obtained with sensitivities of 3087 and 760 Hz/ppm respectively. Very low limit of detection (LOD) values (9 and 40 ppb for DMMP and DPGME, respectively) were calculated from the achieved experimental data. The sensor exhibited outstanding sensitivity, good linearity and repeatability to all simulants tested. The detection mechanism is here explained in terms of hydrogen bonding formation between the tested CWA simulants and GO.

  4. Bioaccumulation of chemical warfare agents, energetic materials, and metals in deep-sea shrimp from discarded military munitions sites off Pearl Harbor (United States)

    Koide, Shelby; Silva, Jeff A. K.; Dupra, Vilma; Edwards, Margo


    The bioaccumulation of munitions-related chemicals at former military deep-water disposal sites is poorly understood. This paper presents the results of human-food-item biota sampling to assess the potential for bioaccumulation of chemical warfare agents, energetic materials, arsenic, and additional munitions-related metals in deep-sea shrimp tissue samples collected during the Hawai'i Undersea Military Munitions Assessment (HUMMA) project to date. The HUMMA investigation area is located within a former munitions sea-disposal site located south of Pearl Harbor on the island of O'ahu, Hawai'i, designated site Hawaii-05 (HI-05) by the United States Department of Defense. Indigenous deep-sea shrimp (Heterocarpus ensifer) were caught adjacent to discarded military munitions (DMM) and at control sites where munitions were absent. Tissue analysis results showed that chemical warfare agents and their degradation products were not present within the edible portions of these samples at detectable concentrations, and energetic materials and their degradation products were detected in only a few samples at concentrations below the laboratory reporting limits. Likewise, arsenic, copper, and lead concentrations were below the United States Food and Drug Administration's permitted concentrations of metals in marine biota tissue (if defined), and their presence within these samples could not be attributed to the presence of DMM within the study area based on a comparative analysis of munitions-adjacent and control samples collected. Based on this current dataset, it can be concluded that DMM existing within the HUMMA study area is not contributing to the bioaccumulation of munitions-related chemicals for the biota species investigated to date.

  5. Roman Warfare

    Directory of Open Access Journals (Sweden)

    D.B. Saddington


    Full Text Available

    ROTH, Jonathan P 2009. Roman Warfare. Cambridge: Cambridge University Press. Pbk. R250. ISBN 978-0-521-53726-1.

    Jonathan Roth of San Jose State University, known as an expert on military logistics, has written this attractive Cambridge Introduction to Roman Civilization volume on Roman Warfare. The series is designed for students with no prior knowledge of Roman antiquity. The book comprises an Introduction on Sources and Methods (pp. 1-6 and 15 chapters on Roman warfare from the beginnings to the fall of the Western Empire in AD 476, using a chronological approach. There are 68 illustrations and maps, a Timeline, a Glossary, a Glossary of People, a Bibliography (which includes several websites and an Index.

  6. Governing Warfare

    DEFF Research Database (Denmark)

    Harste, Gorm

      It would seem as though warfare has gotten out of control, not only in Iraq and Afghanistan, but also in Central Africa. The paper outlines the strategic history of politically controlled warfare since the early Enlightenment. The argument is that control is implausible. The idea of control has...... the risks of lacking unity and displays the organisational trap to the fatal political myth of controlled warfare: Does it come from the military organisation system itself, from political ideologies of goal-rational governance, or from the chameleonic logic of wars?  ...... administration. While organisation systems continue to make some kind of political control possible, this is not the case in relation to wars. The organisation system is the in-between that should mediatise politics and war but is not functionally equivalent to just and unjust wars. The paper investigates...

  7. Advances in Biotechnology and Genetic Engineering: Implications for the Development of New Biological Warfare Agents (United States)


    fever •= Cholera •= Ricin •= Clostridium perfringens •= Shigella •= Encephalomyelitis viruses •= Smallpox •= Glanders •= Tularemia •= Hemorrhagic... transgenic animals by transferring genes from other animals into mice. 1981 Mary Harper and two colleagues mapped the gene for insulin. That year...GenPharm International, Inc. created the first transgenic dairy cow. The cow was used to produce human milk proteins for infant formula. 1990 A four

  8. 75 FR 76460 - Lymphohematopoietic Cancers Induced by Chemicals and Other Agents: Overview and Implications for... (United States)


    ... AGENCY Lymphohematopoietic Cancers Induced by Chemicals and Other Agents: Overview and Implications for..., ``Lymphohematopoietic Cancers Induced by Chemicals and Other Agents: Overview and Implications for Risk Assessment.... ADDRESSES: The draft ``Lymphohematopoietic Cancers Induced by Chemicals and Other Agents: Overview...

  9. Development of the HS-SPME-GC-MS/MS method for analysis of chemical warfare agent and their degradation products in environmental samples. (United States)

    Nawała, Jakub; Czupryński, Krzysztof; Popiel, Stanisław; Dziedzic, Daniel; Bełdowski, Jacek


    After World War II approximately 50,000 tons of chemical weapons were dumped in the Baltic Sea by the Soviet Union under the provisions of the Potsdam Conference on Disarmament. These dumped chemical warfare agents still possess a major threat to the marine environment and to human life. Therefore, continue monitoring of these munitions is essential. In this work, we present the application of new solid phase microextraction fibers in analysis of chemical warfare agents and their degradation products. It can be concluded that the best fiber for analysis of sulfur mustard and its degradation products is butyl acrylate (BA), whereas for analysis of organoarsenic compounds and chloroacetophenone, the best fiber is a co-polymer of methyl acrylate and methyl methacrylate (MA/MMA). In order to achieve the lowest LOD and LOQ the samples should be divided into two subsamples. One of them should be analyzed using a BA fiber, and the second one using a MA/MMA fiber. When the fast analysis is required, the microextraction should be performed by use of a butyl acrylate fiber because the extraction efficiency of organoarsenic compounds for this fiber is acceptable. Next, we have elaborated of the HS-SPME-GC-MS/MS method for analysis of CWA degradation products in environmental samples using laboratory obtained fibers The analytical method for analysis of organosulfur and organoarsenic compounds was optimized and validated. The LOD's for all target chemicals were between 0.03 and 0.65 ppb. Then, the analytical method developed by us, was used for the analysis of sediment and pore water samples from the Baltic Sea. During these studies, 80 samples were analyzed. It was found that 25 sediments and 5 pore water samples contained CWA degradation products such as 1,4-dithiane, 1,4-oxathiane or triphenylarsine, the latter being a component of arsine oil. The obtained data is evidence that the CWAs present in the Baltic Sea have leaked into the general marine environment.

  10. Chemical Warfare Agent Simulants in Gamble’s Fluid: Is the Fluid Toxic? Can It Be Made Safer by Inclusion of Solid Nanocrystalline Metal Oxides?

    Directory of Open Access Journals (Sweden)

    Dennis Karote


    Full Text Available The reactions of chemical warfare agent simulants, 2-chloroethyl ethyl sulfide (2-CEES and di-i-propyl fluoro phosphate (DFP, in fluids have been investigated. Data analyses confirm the major degradation pathway to be hydrolysis of 2-CEES to 2-hydroxyethyl ethyl sulfide, along with minor self-condensation products. Among the three fluids examined, 2-CEES degradation was the fastest in Gamble’s fluid during a 96 h period. Upon addition of Exceptional Hazard Attenuation Materials (EHAMs to 2-CEES containing Gamble’s fluid, degradation was generally improved during the first 24 h period. The 96 h outcome was similar for fluid samples with or without EHAM 2 and EHAM 4. EHAM 1-added fluid contained only one degradation product, 2-nitroethyl ethyl sulfide. DFP degradation was the slowest in Gamble’s fluid, but was enhanced by the addition of EHAMs. FTIR and solid state 31P NMR confirm the destructive adsorption of 2-CEES and DFP by the EHAMs. The results collectively demonstrate that 2-CEES and DFP decompose to various extents in Gamble’s fluid over a 96 h period but the fluid still contains a considerable amount of intact simulant. EHAM 1 appears to be promising for 2-CEES and DFP mitigation while EHAM 2 and EHAM 4 work well for early on concentration reduction of 2-CEES and DFP.

  11. Development of a Polymerase Chain Reaction Assay for Detection of Burkholderia mallei, a Potent Biological Warfare Agent



    Burkholderia mallei is the etiological agent of glanders, primarily a disease of equines. B. mallei is closely related to B. pseudomallei, the causative agent of melioidosis. Therefore, detection of B. mallei and its differentiation from B. pseudomallei, has always been troublesome. In present investigation, a B. mallei specific DNA sequence was identified by performing BLASTn search using ~3000 ORFs of B. mallei NCTC 10229. A polymerase chain reaction (PCR) assay with internal amplification ...

  12. Sensitive monitoring of volatile chemical warfare agents in air by atmospheric pressure chemical ionization mass spectrometry with counter-flow introduction. (United States)

    Seto, Yasuo; Kanamori-Kataoka, Mieko; Tsuge, Koichiro; Ohsawa, Isaac; Iura, Kazumitsu; Itoi, Teruo; Sekiguchi, Hiroyuki; Matsushita, Koji; Yamashiro, Shigeharu; Sano, Yasuhiro; Sekiguchi, Hiroshi; Maruko, Hisashi; Takayama, Yasuo; Sekioka, Ryoji; Okumura, Akihiko; Takada, Yasuaki; Nagano, Hisashi; Waki, Izumi; Ezawa, Naoya; Tanimoto, Hiroyuki; Honjo, Shigeru; Fukano, Masumi; Okada, Hidehiro


    A new method for sensitively and selectively detecting chemical warfare agents (CWAs) in air was developed using counter-flow introduction atmospheric pressure chemical ionization mass spectrometry (MS). Four volatile and highly toxic CWAs were examined, including the nerve gases sarin and tabun, and the blister agents mustard gas (HD) and Lewisite 1 (L1). Soft ionization was performed using corona discharge to form reactant ions, and the ions were sent in the direction opposite to the airflow by an electric field to eliminate the interfering neutral molecules such as ozone and nitrogen oxide. This resulted in efficient ionization of the target CWAs, especially in the negative ionization mode. Quadrupole MS (QMS) and ion trap tandem MS (ITMS) instruments were developed and investigated, which were movable on the building floor. For sarin, tabun, and HD, the protonated molecular ions and their fragment ions were observed in the positive ion mode. For L1, the chloride adduct ions of L1 hydrolysis products were observed in negative ion mode. The limit of detection (LOD) values in real-time or for a 1 s measurement monitoring the characteristic ions were between 1 and 8 μg/m(3) in QMS instrument. Collision-induced fragmentation patterns for the CWAs were observed in an ITMS instrument, and optimized combinations of the parent and daughter ion pairs were selected to achieve real-time detection with LOD values of around 1 μg/m(3). This is a first demonstration of sensitive and specific real-time detection of both positively and negatively ionizable CWAs by MS instruments used for field monitoring.


    Abstract was given as an oral platform presentation at the Pittsburgh Conference, Orlando FL (March 5-9, 2006). Research described is the development of sensors based on molecular surface imprinting. Applications include the monitoring of chemical and biological agents and inse...


    Enzymatic test kits, generally designed to be handheld and portable, detect the presence of chemical agents, carbamate pesticides, and/or organophosphate pesticides by relying on the reaction of the cholinesterase enzyme. Under normal conditions, the enzyme reacts as expected wi...

  15. Effective methylation of phosphonic acids related to chemical warfare agents mediated by trimethyloxonium tetrafluoroborate for their qualitative detection and identification by gas chromatography-mass spectrometry. (United States)

    Valdez, Carlos A; Leif, Roald N; Alcaraz, Armando


    The effective methylation of phosphonic acids related to chemical warfare agents (CWAs) employing trimethyloxonium tetrafluoroborate (TMO·BF4) for their qualitative detection and identification by gas chromatography-mass spectrometry (GC-MS) is presented. The methylation occurs in rapid fashion (1 h) and can be conveniently carried out at ambient temperature, thus providing a safer alternative to the universally employed diazomethane-based methylation protocols. Optimization of the methylation parameters led us to conclude that methylene chloride was the ideal solvent to carry out the derivatization, and that even though methylated products can be observed surfacing after only 1 h, additional time was not found to be detrimental but beneficial to the process particularly when dealing with analytes at low concentrations (∼10 μg mL(-1)). Due to its insolubility in methylene chloride, TMO·BF4 conveniently settles to the bottom during the reaction and does not produce additional interfering by-products that may further complicate the GC-MS analysis. The method was demonstrated to successfully methylate a variety of Schedule 2 phosphonic acids, including their half esters, resulting in derivatives that were readily detected and identified using the instrument's spectral library. Most importantly, the method was shown to simultaneously methylate a mixture of the organophosphorus-based nerve agent hydrolysis products: pinacolyl methylphosphonate (PMPA), cyclohexyl methylphosphonate (CyMPA) and ethyl methylphosphonate (EMPA) (at a 10 μg mL(-1) concentration each) in a fatty acid ester-rich organic matrix (OPCW-PT-O3) featured in the 38th Organisation for the Prohibition of Chemical Weapons (OPCW) Proficiency Test. In addition, the protocol was found to effectively methylate N,N-diethylamino ethanesulfonic acid and N,N-diisopropylamino ethanesulfonic acid that are products arising from the oxidative degradation of the V-series agents VR and VX respectively. The

  16. Rapid Analysis of Chemical Warfare Agents and Their Hydrolysis Products by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) (United States)


    to diethyl hydrogen phosphate, suggesting that hydrolysis of nerve agents to their initial acids would be significant following autoclaving... toxins and related compounds: state of the art and future prospects. J. Chromatogr. A, 814, 1- 23. [4] Munro, N.B., Talmage, S.S., Griffin, G.D., Waters...Morrissey, K.M. and Durst, H.D. (2000). Trace determination of isopropyl methylphosphonofluoridate (GB) and bis (2-chloroethyl) sulfide (HD) in chemical

  17. Toxic Chemicals in the Soil Environment. Volume 2. Interactions of Some Toxic Chemicals/Chemical Warfare Agents and Soils (United States)


    cholinesterase inhibitors . At least one, armin (O-ethyl’,ethyl 0,p-nit rophenyl phosphonate), is among the moot .powerful known choliniesterase inhibitor ...and is equivalent to the nerve 4 agents (Feat and Schmidt, 1973). All have been used as growth Inhibitors or terminators for some organisms...there was inhibition of the urease and oxidase enzymes. 2.2.4 Effects of Ozone and Sunlight on Orgenophoapborua Pesticides Spencer et al. (1980

  18. Fate of the chemical warfare agent O-ethyl S-2-diisopropylaminoethyl methylphosphonothiolate (VX) on soil following accelerant-based fire and liquid decontamination. (United States)

    Gravett, M R; Hopkins, F B; Self, A J; Webb, A J; Timperley, C M; Riches, J R


    procedures and analytical methods suitable for investigating accelerant and decontaminant-soaked soil samples are presented. VX and its degradation products and/or impurities were detected under all the conditions studied, demonstrating that accelerant-based fire and liquid-based decontamination and then fire are unlikely to prevent the retrieval of evidence of chemical warfare agent (CWA) testing. This is the first published study of the effects of an accelerant-based fire on a CWA in environmental samples. The results will inform defence and security-based organisations worldwide and support the verification activities of the Organisation for the Prohibition of Chemical Weapons (OPCW), winner of the 2013 Nobel Peace Prize for its extensive efforts to eliminate chemical weapons.

  19. Wipe selection for the analysis of surface materials containing chemical warfare agent nitrogen mustard degradation products by ultra-high pressure liquid chromatography-tandem mass spectrometry. (United States)

    Willison, Stuart A


    Degradation products arising from nitrogen mustard chemical warfare agent were deposited on common urban surfaces and determined via surface wiping, wipe extraction, and liquid chromatography–tandem mass spectrometry detection. Wipes investigated included cotton gauze, glass fiber filter, non-woven polyester fiber and filter paper, and surfaces included several porous (vinyl tile, painted drywall, wood) and mostly non-porous (laminate, galvanized steel, glass) surfaces. Wipe extracts were analyzed by ultra-high pressure liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) and compared with high performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) results. An evaluation of both techniques suggests UPLC–MS/MS provides a quick and sensitive analysis of targeted degradation products in addition to being nearly four times faster than a single HPLC run, allowing for greater throughput during a wide-spread release concerning large-scale contamination and subsequent remediation events. Based on the overall performance of all tested wipes, filter paper wipes were selected over other wipes because they did not contain interferences or native species (TEA and DEA) associated with the target analytes, resulting in high percent recoveries and low background levels during sample analysis. Other wipes, including cotton gauze, would require a pre-cleaning step due to the presence of large quantities of native species or interferences of the targeted analytes. Percent recoveries obtained from a laminate surface were 47–99% for all nitrogen mustard degradation products. The resulting detection limits achieved from wipes were 0.2 ng/cm(2) for triethanolamine (TEA), 0.03 ng/cm(2) for N-ethyldiethanolamine (EDEA), 0.1 ng/cm(2) for N-methyldiethanolamine (MDEA), and 0.1 ng/cm(2) for diethanolamine (DEA).

  20. Comparison of latex body paint with wetted gauze wipes for sampling the chemical warfare agents VX and sulfur mustard from common indoor surfaces. (United States)

    Hernon-Kenny, Laura A; Behringer, Deborah L; Crenshaw, Michael D


    Comparison of solvent-wetted gauze with body paint, a peelable surface sampling media, for the sampling of the chemical warfare agents VX and sulfur mustard from nine surfaces was performed. The nine surfaces sampled are those typical of interior public venues and include smooth, rough, porous, and non-porous surfaces. Overall, solvent-wetted gauze (wipes) performed better for the recovery of VX from non-porous surfaces while body paint (BP) performed better for the porous surfaces. The average percent VX recoveries using wipes and BP, respectively, are: finished wood flooring, 86.2%, 71.4%; escalator handrail, 47.3%, 26.7%; stainless steel, 80.5%, 56.1%; glazed ceramic tile, 81.8%, 44.9%; ceiling tile, 1.77%, 13.1%; painted drywall 7.83%, 21.1%; smooth cement, 0.64%, 10.3%; upholstery fabric, 24.6%, 23.1%; unfinished wood flooring, 9.37%, 13.1%. Solvent-wetted gauze performed better for the recovery of sulfur mustard from three of the relatively non-porous surfaces while body paint performed better for the more porous surfaces. The average percent sulfur mustard recoveries using wipes and BP, respectively, are: finished wood flooring, 30.2%, 2.97%; escalator handrail, 4.40%, 4.09%; stainless steel, 21.2%, 3.30%; glazed ceramic tile, 49.7%, 16.7%; ceiling tile, 0.33%, 11.1%; painted drywall 2.05%, 10.6%; smooth cement, 1.20%, 35.2%; upholstery fabric, 7.63%, 6.03%; unfinished wood flooring, 0.90%, 1.74%.

  1. Development of a Polymerase Chain Reaction Assay for Detection of Burkholderia mallei, a Potent Biological Warfare Agent

    Directory of Open Access Journals (Sweden)

    Vijai Pal


    Full Text Available Burkholderia mallei is the etiological agent of glanders, primarily a disease of equines. B. mallei is closely related to B. pseudomallei, the causative agent of melioidosis. Therefore, detection of B. mallei and its differentiation from B. pseudomallei, has always been troublesome. In present investigation, a B. mallei specific DNA sequence was identified by performing BLASTn search using ~3000 ORFs of B. mallei NCTC 10229. A polymerase chain reaction (PCR assay with internal amplification control (IAC was developed for detection of B. mallei and its differentiation from B. pseudomallei. The PCR assay could amplify a specific 224-bp fragment from all the six B. mallei strains used in the study, whereas other closely related organisms were tested negative. The detection limit of the assay was found to be 10 pg of purified DNA of B. mallei. Incorporation of IAC in the assay makes the results reliable as false negative results which may arise due to presence of PCR inhibitors, can be avoided. For validation, the assay was tested on tap water, Bengal gram and grass artificially spiked with B. mallei. The developed assay can be used as a simple and rapid tool for detection of B. mallei.

  2. Iron oxide functionalized graphene nano-composite for dispersive solid phase extraction of chemical warfare agents from aqueous samples. (United States)

    Chinthakindi, Sridhar; Purohit, Ajay; Singh, Varoon; Tak, Vijay; Goud, D Raghavender; Dubey, D K; Pardasani, Deepak


    Present study deals with the preparation and evaluation of graphene based magnetic nano-composite for dispersive solid phase extraction of Chemical Weapons Convention (CWC) relevant chemicals from aqueous samples. Nano-composite, Fe3O4@SiO2-G was synthesized by covalently bonding silica coated Fe3O4 onto the graphene sheets. Nerve agents (NA), Sulfur mustard (SM) and their non-toxic environmental markers were the target analytes. Extraction parameters like amount of sorbent, extraction time and desorption conditions were optimized. Dispersion of 20 milligram of sorbent in 200mL of water sample for 20min. followed by methanol/chloroform extraction produced average to good recoveries (27-94%) of targeted analytes. Recoveries of real agents exhibited great dependency upon sample pH and ionic strength. Sarin produced maximum recovery under mild acidic conditions (56% at pH 5) while VX demanded alkaline media (83% at pH 9). Salts presence in the aqueous samples was found to be advantageous, raising the recoveries to as high as 94% for SM. Excellent limits of detection (LOD) for sulphur mustard and VX (0.11ngmL(-1) and 0.19ngmL(-1) respectively) proved the utility of the developed method for the off-site analysis of CWC relevant chemicals.

  3. Medical countermeasure against respiratory toxicity and acute lung injury following inhalation exposure to chemical warfare nerve agent VX. (United States)

    Nambiar, Madhusoodana P; Gordon, Richard K; Rezk, Peter E; Katos, Alexander M; Wajda, Nikolai A; Moran, Theodore S; Steele, Keith E; Doctor, Bhupendra P; Sciuto, Alfred M


    To develop therapeutics against lung injury and respiratory toxicity following nerve agent VX exposure, we evaluated the protective efficacy of a number of potential pulmonary therapeutics. Guinea pigs were exposed to 27.03 mg/m(3) of VX or saline using a microinstillation inhalation exposure technique for 4 min and then the toxicity was assessed. Exposure to this dose of VX resulted in a 24-h survival rate of 52%. There was a significant increase in bronchoalveolar lavage (BAL) protein, total cell number, and cell death. Surprisingly, direct pulmonary treatment with surfactant, liquivent, N-acetylcysteine, dexamethasone, or anti-sense syk oligonucleotides 2 min post-exposure did not significantly increase the survival rate of VX-exposed guinea pigs. Further blocking the nostrils, airway, and bronchioles, VX-induced viscous mucous secretions were exacerbated by these aerosolized treatments. To overcome these events, we developed a strategy to protect the animals by treatment with atropine. Atropine inhibits muscarinic stimulation and markedly reduces the copious airway secretion following nerve agent exposure. Indeed, post-exposure treatment with atropine methyl bromide, which does not cross the blood-brain barrier, resulted in 100% survival of VX-exposed animals. Bronchoalveolar lavage from VX-exposed and atropine-treated animals exhibited lower protein levels, cell number, and cell death compared to VX-exposed controls, indicating less lung injury. When pulmonary therapeutics were combined with atropine, significant protection to VX-exposure was observed. These results indicate that combinations of pulmonary therapeutics with atropine or drugs that inhibit mucous secretion are important for the treatment of respiratory toxicity and lung injury following VX exposure.

  4. Development of a gas-cylinder-free plasma desorption/ionization system for on-site detection of chemical warfare agents. (United States)

    Iwai, Takahiro; Kakegawa, Ken; Aida, Mari; Nagashima, Hisayuki; Nagoya, Tomoki; Kanamori-Kataoka, Mieko; Miyahara, Hidekazu; Seto, Yasuo; Okino, Akitoshi


    A gas-cylinder-free plasma desorption/ionization system was developed to realize a mobile on-site analytical device for detection of chemical warfare agents (CWAs). In this system, the plasma source was directly connected to the inlet of a mass spectrometer. The plasma can be generated with ambient air, which is drawn into the discharge region by negative pressure in the mass spectrometer. High-power density pulsed plasma of 100 kW could be generated by using a microhollow cathode and a laboratory-built high-intensity pulsed power supply (pulse width: 10-20 μs; repetition frequency: 50 Hz). CWAs were desorbed and protonated in the enclosed space adjacent to the plasma source. Protonated sample molecules were introduced to the mass spectrometer by airflow through the discharge region. To evaluate the analytical performance of this device, helium and air plasma were directly irradiated to CWAs in the gas-cylinder-free plasma desorption/ionization system and the protonated molecules were analyzed by using an ion-trap mass spectrometer. A blister agent (nitrogen mustard 3) and nerve gases [cyclohexylsarin (GF), tabun (GA), and O-ethyl S-2-N,N-diisopropylaminoethyl methylphosphonothiolate (VX)] in solution in n-hexane were applied to the Teflon rod and used as test samples, after solvent evaporation. As a result, protonated molecules of CWAs were successfully observed as the characteristic ion peaks at m/z 204, 181, 163, and 268, respectively. In air plasma, the limits of detection were estimated to be 22, 20, 4.8, and 1.0 pmol, respectively, which were lower than those obtained with helium plasma. To achieve quantitative analysis, calibration curves were made by using CWA stimulant dipinacolyl methylphosphonate as an internal standard; straight correlation lines (R(2) = 0.9998) of the peak intensity ratios (target per internal standard) were obtained. Remarkably, GA and GF gave protonated dimer ions, and the ratios of the protonated dimer ions to the protonated

  5. Effective, Facile, and Selective Hydrolysis of the Chemical Warfare Agent VX Using Zr6-Based Metal-Organic Frameworks. (United States)

    Moon, Su-Young; Wagner, George W; Mondloch, Joseph E; Peterson, Gregory W; DeCoste, Jared B; Hupp, Joseph T; Farha, Omar K


    The nerve agent VX is among the most toxic chemicals known to mankind, and robust solutions are needed to rapidly and selectively deactivate it. Herein, we demonstrate that three Zr6-based metal-organic frameworks (MOFs), namely, UiO-67, UiO-67-NH2, and UiO-67-N(Me)2, are selective and highly active catalysts for the hydrolysis of VX. Utilizing UiO-67, UiO-67-NH2, and UiO-67-N(Me)2 in a pH 10 buffered solution of N-ethylmorpholine, selective hydrolysis of the P-S bond in VX was observed. In addition, UiO-67-N(Me)2 was found to catalyze VX hydrolysis with an initial half-life of 1.8 min. This half-life is nearly 3 orders of magnitude shorter than that of the only other MOF tested to date for hydrolysis of VX and rivals the activity of the best nonenzymatic materials. Hydrolysis utilizing Zr-based MOFs is also selective and facile in the absence of pH 10 buffer (just water) and for the destruction of the toxic byproduct EA-2192.

  6. Determination of contamination of a chemical warfare-proof operating theatre with volatile anaesthetic agents and assessment of anaesthetic gas scavenging systems. (United States)

    Yoganathan, S; Johnston, I G; Parnell, C J; Houghton, I T; Restall, J


    Three types of anaesthetic waste scavenging systems (active antipollution system, Papworth Block passive system and activated charcoal absorber system) were compared with a non-scavenging control to assess their effectiveness in reducing waste halothane concentrations in a chemical warfare-proof operating theatre. All three systems were found to reduce the level of pollution significantly.

  7. Analysis of chemical warfare agents in organic liquid samples with magnetic dispersive solid phase extraction and gas chromatography mass spectrometry for verification of the chemical weapons convention. (United States)

    Singh, Varoon; Purohit, Ajay Kumar; Chinthakindi, Sridhar; Goud, Raghavender D; Tak, Vijay; Pardasani, Deepak; Shrivastava, Anchal Roy; Dubey, Devendra Kumar


    A simple, sensitive and low temperature sample preparation method is developed for detection and identification of Chemical Warfare Agents (CWAs) and scheduled esters in organic liquid using magnetic dispersive solid phase extraction (MDSPE) followed by gas chromatography-mass spectrometry analysis. The method utilizes Iron oxide@Poly(methacrylic acid-co-ethylene glycol dimethacrylate) resin (Fe2O3@Poly(MAA-co-EGDMA)) as sorbent. Variants of these sorbents were prepared by precipitation polymerization of methacrylic acid-co-ethylene glycol dimethacrylate (MAA-co-EGDMA) onto Fe2O3 nanoparticles. Fe2O3@poly(MAA-co-EGDMA) with 20% MAA showed highest recovery of analytes. Extractions were performed with magnetic microspheres by MDSPE. Parameters affecting the extraction efficiency were studied and optimized. Under the optimized conditions, method showed linearity in the range of 0.1-3.0μgmL(-1) (r(2)=0.9966-0.9987). The repeatability and reproducibility (relative standard deviations (RSDs) %) were in the range of 4.5-7.6% and 3.4-6.2% respectively for organophosphorous esters in dodecane. Limits of detection (S/N=3/1) and limit of quantification (S/N=10/1) were found to be in the range of 0.05-0.1μgmL(-1) and 0.1-0.12μgmL(-1) respectively in SIM mode for selected analytes. The method was successfully validated and applied to the extraction and identification of targeted analytes from three different organic liquids i.e. n-hexane, dodecane and silicon oil. Recoveries ranged from 58.7 to 97.3% and 53.8 to 95.5% at 3μgmL(-1) and 1μgmL(-1) spiking concentrations. Detection of diethyl methylphosphonate (DEMP) and O-Ethyl S-2-diisopropylaminoethyl methylphosphonothiolate (VX) in samples provided by the Organization for Prohibition of Chemical Weapons Proficiency Test (OPCW-PT) proved the utility of the developed method for the off-site analysis of CWC relevant chemicals.

  8. Hepatotoxicity by Drugs: The Most Common Implicated Agents

    Directory of Open Access Journals (Sweden)

    Einar S. Björnsson


    Full Text Available Idiosyncratic drug-induced liver injury (DILI is an underreported and underestimated adverse drug reaction. Information on the documented hepatotoxicity of drugs has recently been made available by a website that can be accessed in the public domain: LiverTox ( According to critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury. Only 48 drugs had more than 50 case reports of DILI. Amoxicillin-clavulanate is the most commonly implicated agent leading to DILI in the prospective series. In a recent prospective study, liver injury due to amoxicillin-clavulanate was found to occur in approximately one out of 2300 users. Drugs with the highest risk of DILI in this study were azathioprine and infliximab.

  9. Hepatotoxicity by Drugs: The Most Common Implicated Agents. (United States)

    Björnsson, Einar S


    Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. Information on the documented hepatotoxicity of drugs has recently been made available by a website that can be accessed in the public domain: LiverTox ( According to critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury. Only 48 drugs had more than 50 case reports of DILI. Amoxicillin-clavulanate is the most commonly implicated agent leading to DILI in the prospective series. In a recent prospective study, liver injury due to amoxicillin-clavulanate was found to occur in approximately one out of 2300 users. Drugs with the highest risk of DILI in this study were azathioprine and infliximab.

  10. Flying Electronic Warfare Laboratory (United States)

    Federal Laboratory Consortium — FUNCTION: Provides NP-3D aircraft host platforms for Effectiveness of Navy Electronic Warfare Systems (ENEWS) Program antiship missile (ASM) seeker simulators used...

  11. Flying Electronic Warfare Laboratory (United States)

    Federal Laboratory Consortium — FUNCTION: Provides NP-3D aircraft host platforms for Effectiveness of Navy Electronic Warfare Systems (ENEWS) Program antiship missile (ASM) seeker simulators used...

  12. Chemical and biological warfare: General studies. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)



    The bibliography contains citations concerning federally sponsored and conducted studies into chemical and biological warfare operations and planning. These studies cover areas not addressed in other parts of this series. The topics include production and storage of agents, delivery techniques, training, military and civil defense, general planning studies, psychological reactions to chemical warfare, evaluations of materials exposed to chemical agents, and studies on banning or limiting chemical warfare. Other published searches in this series on chemical warfare cover detection and warning, defoliants, protection, and biological studies, including chemistry and toxicology. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  13. Chemical and biological warfare: General studies. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)



    The bibliography contains citations concerning federally sponsored and conducted studies into chemical and biological warfare operations and planning. These studies cover areas not addressed in other parts of this series. The topics include production and storage of agents, delivery techniques, training, military and civil defense, general planning studies, psychological reactions to chemical warfare, evaluations of materials exposed to chemical agents, and studies on banning or limiting chemical warfare. Other published searches in this series on chemical warfare cover detection and warning, defoliants, protection, and biological studies, including chemistry and toxicology.(Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  14. The Concentration Probability Density Function With Implications for Probabilistic Modeling of Chemical Warfare Agent Detector Responses for Source Reconstruction (United States)


    persions en panaches dans un certain nombre de réseaux d’obstacles (ex. : des réseaux variés d’obstacles cubiques et non cubiques, arrangés en...mesurée (en dépit du fait que les deux modèles de distribu- tion donnaient une bonne représentation des quatre premiers moments de concentrations). On...dans l’atmosphère puisqu’il faudrait être capable de déterminer le nombre de sources, et pour chacune de ces sources, le lieu d’émission, la

  15. Defining cyber warfare

    Directory of Open Access Journals (Sweden)

    Dragan D. Mladenović


    Full Text Available Cyber conflicts represent a new kind of warfare that is technologically developing very rapidly. Such development results in more frequent and more intensive cyber attacks undertaken by states against adversary targets, with a wide range of diverse operations, from information operations to physical destruction of targets. Nevertheless, cyber warfare is waged through the application of the same means, techniques and methods as those used in cyber criminal, terrorism and intelligence activities. Moreover, it has a very specific nature that enables states to covertly initiate attacks against their adversaries. The starting point in defining doctrines, procedures and standards in the area of cyber warfare is determining its true nature. In this paper, a contribution to this effort was made through the analysis of the existing state doctrines and international practice in the area of cyber warfare towards the determination of its nationally acceptable definition.

  16. Rethinking Defensive Information Warfare (United States)


    electronic warfare, and special information operations. Defensive information operations ensure timely, accurate, and relevant information access...information and information systems. IA, physical security, OPSEC, counter-deception, counter-psyops, CI, EW, and special information operations. Ensure

  17. Optimization of Quantitative Proteomics Using 2-Dimensional Difference Gel Electrophoresis to Characterize Molecular Mechanisms of Chemical Warfare Nerve Agent Exposure in the Rat Brain (United States)


    damaging effects of nerve agents. Currently, one prophylactic (pyridostigmine) and three therapeutic drugs (atropine, pralidoxime chloride, and diazepam ...and J.H. McDonough, Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication. Archives of

  18. On the Probability of Predicting and Mapping Traditional Warfare Measurements to the Cyber Warfare Domain

    CSIR Research Space (South Africa)

    Grobler, M


    Full Text Available to cyber warfare. This article aims to provide evidence towards the probability of predicting and mapping traditional warfare measurements to the cyber warfare domain. Currently the only way of cyber warfare measurement is located in traditional information...

  19. Cutaneous challenge with chemical warfare agents in the SKH-1 hairless mouse (II): effects of some currently used skin decontaminants (RSDL and Fuller's earth) against liquid sulphur mustard and VX exposure. (United States)

    Taysse, L; Dorandeu, F; Daulon, S; Foquin, A; Perrier, N; Lallement, G; Breton, P


    Using the hairless mouse screening model presented in the companion paper(1) the aim of this study was to assess two skin decontaminating systems: Fuller's earth (FE) and Reactive Skin Decontamination Lotion (RSDL) against two extremely toxic chemical warfare agents that represent a special percutaneous hazard, sulphur mustard (SM) and O-ethyl-S-(2[di-isopropylamino]ethyl)methyl-phosphonothioate (VX). Five minutes after being exposed on the back to either 2 µL of neat sulphur mustard or 50 µ of diluted VX, mice were decontaminated. Both systems were able to reduce blisters 3 days after SM exposure. However, RSDL was found to be more efficient than FE in reducing the necrosis of the epidermis and erosion. In the case of VX exposure, RSDL, whatever the ratio of decontaminant to toxicant used (RSDL 10, 20, 50), was not able to sufficiently prevent the inhibition of plasma cholinesterases taken as a surrogate marker of exposure and toxicity. Only FE reduced significantly the ChE inhibition. Some of these observations are different from our previous results obtained in domestic swine and these changes are thus discussed in the perspective of using SKH-1 hairless mice for the initial in vivo screening of decontaminants.

  20. 生物战剂气溶胶侦检技术国外相关专利分析%Analysis of Bio-aerosol Warfare Agent Detection and Identification Technology Based on Foreign Patent Information

    Institute of Scientific and Technical Information of China (English)

    李鹏; 王运斗


    Patent information is the latest achievement of scientific research program which can reflect the last orientation of technology. This paper chooses SOOPAT as the patent data source, studies retrieval patent data, then obtains the current situation of bio - aerosol detection and identification technology, key areas and trends. Next, the article proposes reflections on the domestic development of biological warfare agents aerosol detect technology. The results have significant guidance for the development of related biological detectors.%专利信息作为科研活动的最新成果,能反映技术的最新动态.选择SOOPAT作为专利数据检索源,通过对检索到的专利数据进行分析研究,得出生物战剂气溶胶侦检技术现状、关键领域和发展趋势,然后对国内发展生物战剂气溶胶侦检技术提出几点思考.研究结果对于指导相关生物侦检装备的发展具有一定的指导意义.

  1. Identification of the factors that govern the ability of therapeutic antibodies to provide postchallenge protection against botulinum toxin: a model for assessing postchallenge efficacy of medical countermeasures against agents of bioterrorism and biological warfare. (United States)

    Al-Saleem, Fetweh H; Nasser, Zidoon; Olson, Rebecca M; Cao, Linsen; Simpson, Lance L


    Therapeutic antibodies are one of the major classes of medical countermeasures that can provide protection against potential bioweapons such as botulinum toxin. Although a broad array of antibodies are being evaluated for their ability to neutralize the toxin, there is little information that defines the circumstances under which these antibodies can be used. In the present study, an effort was made to quantify the temporal factors that govern therapeutic antibody use in a postchallenge scenario. Experiments were done involving inhalation administration of toxin to mice, intravenous administration to mice, and direct application to murine phrenic nerve-hemidiaphragm preparations. As part of this study, several pharmacokinetic characteristics of botulinum toxin and neutralizing antibodies were measured. The core observation that emerged from the work was that the window of opportunity within which postchallenge administration of antibodies exerted a beneficial effect increased as the challenge dose of toxin decreased. The critical factor in establishing the window of opportunity was the amount of time needed for fractional redistribution of a neuroparalytic quantum of toxin from the extraneuronal space to the intraneuronal space. This redistribution event was a dose-dependent phenomenon. It is likely that the approach used to identify the factors that govern postchallenge efficacy of antibodies against botulinum toxin can be used to assess the factors that govern postchallenge efficacy of medical countermeasures against any agent of bioterrorism or biological warfare.

  2. Biological warfare, bioterrorism, and biocrime. (United States)

    Jansen, H J; Breeveld, F J; Stijnis, C; Grobusch, M P


    Biological weapons achieve their intended target effects through the infectivity of disease-causing infectious agents. The ability to use biological agents in warfare is prohibited by the Biological and Toxin Weapon Convention. Bioterrorism is defined as the deliberate release of viruses, bacteria or other agents used to cause illness or death in people, but also in animals or plants. It is aimed at creating casualties, terror, societal disruption, or economic loss, inspired by ideological, religious or political beliefs. The success of bioterroristic attempts is defined by the measure of societal disruption and panic, and not necessarily by the sheer number of casualties. Thus, making only a few individuals ill by the use of crude methods may be sufficient, as long as it creates the impact that is aimed for. The assessment of bioterrorism threats and motives have been described before. Biocrime implies the use of a biological agent to kill or make ill a single individual or small group of individuals, motivated by revenge or the desire for monetary gain by extortion, rather than by political, ideological, religious or other beliefs. The likelihood of a successful bioterrorist attack is not very large, given the technical difficulties and constraints. However, even if the number of casualties is likely to be limited, the impact of a bioterrorist attack can still be high. Measures aimed at enhancing diagnostic and therapeutic capabilities and capacities alongside training and education will improve the ability of society to combat 'regular' infectious diseases outbreaks, as well as mitigating the effects of bioterrorist attacks.

  3. Background chemistry for chemical warfare agents and decontamination processes in support of delisting waste streams at the U.S. Army Dugway Proving Ground, Utah

    Energy Technology Data Exchange (ETDEWEB)

    Rosenblatt, D.H.; Small, M.J.; Kimmell, T.A.; Anderson, A.W.


    The State of Utah, Department of Environmental Quality (DEQ), Division of Solid and Hazardous Waste (DSHW), has declared residues resulting from the demilitarization, treatment, cleanup, and testing of military chemical agents to be hazardous wastes. These residues have been designated as corrosive, reactive, toxic, and acute hazardous (Hazardous Waste No. F999). The RCRA regulations (40 Code of Federal Regulations [CFR] 260-280), the Utah Administrative Code (R-315), and other state hazardous waste programs list specific wastes as hazardous but allow generators to petition the regulator to {open_quotes}delist,{close_quotes} if it can be demonstrated that such wastes are not hazardous. The U.S. Army Test and Evaluation Command (TECOM) believes that certain categories of F999 residues are not hazardous and has obtained assistance from Argonne National Laboratory (Argonne) to make the delisting demonstration. The objective of this project is to delist chemical agent decontaminated residues resulting from materials testing activities and to delist a remediation residue (e.g., contaminated soil). To delist these residues, it must be demonstrated that the residues (1) do not contain hazardous quantities of the listed agents; (2) do not contain hazardous quantities of constituents listed in 40 CFR Part 261, Appendix VIII; (3) do not exhibit other characteristics that could define the residues as hazardous; and (4) do not fail a series of acute toxicity tests. The first phase will focus on a subset of the F999 wastes generated at the U.S. Army Dugway Proving Ground (DPG), where the Army tests the effects of military chemical agents and agent-decontamination procedures on numerous military items. This effort is identified as Phase I of the Delisting Program. Subsequent phases will address other DPG chemical agent decontaminated residues and remediation wastes and similar residues at other installations.

  4. The Physics of Warfare (United States)

    Giordano, Gerardo


    Recently, I was tasked with the creation and execution of a new themed general education physics class called The Physics of Warfare. In the past, I had used the theme of a class, such as the physics of sports medicine, as a way to create homework and in-class activities, generate discussions, and provide an application to demonstrate that physics…

  5. LEXSYS: Architecture and Implication for Intelligent Agent systems

    CERN Document Server

    Robert, Charles A B


    LEXSYS, (Legume Expert System) was a project conceived at IITA (International Institute of Tropical Agriculture) Ibadan Nigeria. It was initiated by the COMBS (Collaborative Group on Maize-Based Systems Research in the 1990. It was meant for a general framework for characterizing on-farm testing for technology design for sustainable cereal-based cropping system. LEXSYS is not a true expert system as the name would imply, but simply a user-friendly information system. This work is an attempt to give a formal representation of the existing system and then present areas where intelligent agent can be applied.

  6. Multi-agents and learning: Implications for Webusage mining. (United States)

    Lotfy, Hewayda M S; Khamis, Soheir M S; Aboghazalah, Maie M


    Characterization of user activities is an important issue in the design and maintenance of websites. Server weblog files have abundant information about the user's current interests. This information can be mined and analyzed therefore the administrators may be able to guide the users in their browsing activity so they may obtain relevant information in a shorter span of time to obtain user satisfaction. Web-based technology facilitates the creation of personally meaningful and socially useful knowledge through supportive interactions, communication and collaboration among educators, learners and information. This paper suggests a new methodology based on learning techniques for a Web-based Multiagent-based application to discover the hidden patterns in the user's visited links. It presents a new approach that involves unsupervised, reinforcement learning, and cooperation between agents. It is utilized to discover patterns that represent the user's profiles in a sample website into specific categories of materials using significance percentages. These profiles are used to make recommendations of interesting links and categories to the user. The experimental results of the approach showed successful user pattern recognition, and cooperative learning among agents to obtain user profiles. It indicates that combining different learning algorithms is capable of improving user satisfaction indicated by the percentage of precision, recall, the progressive category weight and F 1-measure.

  7. Hybrid Warfare: the 21st Century Russian Way of Warfare (United States)


    social, military, information, and diplomatic means. Russian information operations are a critical component of their hybrid theory of warfare which NATO discontinues encroaching on Russia’s sphere of influence and in which Russia ascends to regional hegemony .2 Although unsuccessful, this...Russian model of hybrid warfare illuminates several critical innovations to warfare that transpired while the United States was committed to operations

  8. A computational study of detoxification of lewisite warfare agents by British anti-lewisite: catalytic effects of water and ammonia on reaction mechanism and kinetics. (United States)

    Sahu, Chandan; Pakhira, Srimanta; Sen, Kaushik; Das, Abhijit K


    trans-2-Chlorovinyldichloroarsine (lewisite, L agent, Lew-I) acts as a blistering agents. British anti-lewisite (BAL, 2,3-dimercaptopropanol) has long been used as an L-agent antidote. The main reaction channels for the detoxification proceed via breaking of As-Cl bonds and formation of As-S bonds, producing stable, nontoxic ring product [(2-methyl-1,3,2-dithiarsolan-4-yl)methanol]. M06-2X/GENECP calculations have been carried out to establish the enhanced rate of detoxification mechanism in the presence of NH3 and H2O catalysts in both gas and solvent phases, which has been modeled by use of the polarized continuum model (PCM). In addition, natural bond orbital (NBO) and atoms in molecules (AIM) analysis have been performed to characterize the intermolecular hydrogen bonding in the transition states. Transition-state theory (TST) calculation establishes that the rates of NH3-catalyzed (2.88 × 10(-11) s(-1)) and H2O-catalyzed (2.42 × 10(-11) s(-1)) reactions are reasonably faster than the uncatalyzed detoxification (5.44 × 10(-13) s(-1)). The results obtained by these techniques give new insight into the mechanism of the detoxification process, identification and thermodynamic characterization of the relevant stationary species, the proposal of alternative paths on modeled potential energy surfaces for uncatalyzed reaction, and the rationalization of the mechanistic role played by catalysts and solvents.

  9. Evaluation on the capability of a skin decontaminatant PF2009 to inactivate chemical warfare agents%皮肤洗消剂PF2009对化学毒剂的消毒作用

    Institute of Scientific and Technical Information of China (English)

    刘红岩; 刘艳芹; 应莺; 林京玉; 王伊文; 左国民; 朱海燕; 钟玉绪


    Objective To evaluate the capability of skin decontamination lotion PF2009 to decontaminate chemical warfare agents. Methods The remnant of chemical warfare agents, soman (GD), VX or sulfur mustard(HD), was measured with gas phase chromatography or T-135 method after being mixed with PF2009 for indicated time. The mixtures of PF2009 with GD, VX at a molar ratio of 10:1 was measured by the main agent were administered to rabbits through intraperitoneal injection. 6 days later, the activity of acetylcholinesterase(AChE) in animal blood was determined with the method of DTNB. The survival rate was calculated after counting the living and died rabbits. The mixtures of PF2009 with HD were administered to rabbit skin. The area of injured skin was measured. Histochemical method was employed to observe the pathological change in the injured skin. Results Remnant of GD or VX could not be detected after being mixed with PF2009 at a volume ratio of 150 for 10 min. Under the same mixing condition, decontaminated HD increased from 80% to 94% when prolonging the incubation time from 10 to 60 min. Rabbits were intraperitoneally administered with the mixture of PF2009 with GD at a dose of 454 or 9.00 mg/kg or VX at a dose 3.34 mg/kg. No animals died in PF2009 group. In contrast, all rabbits died in lotion matrix control group during the 6 days' observation. 90% activity of AChE in blood was maintained for PF2009 group when compared with that for un-administered normal animals. The mixture of PF2009 with HD was administered to the rabbit skin at a dose of 1 mg/ cm2. The damage of skin was much lighter in PF2009 group than in lotion matrix control group when being evaluated with the area value of injured skin and histochemical staining. Conclusion The skin decontamination lotion PF2009 is effective in inactivating chemical warfare agents in vitro.%目的 通过检测皮肤洗消剂PF2009对化学毒剂的体外消毒效率,对皮肤洗消剂PF2009的消毒效果进行评价.方法

  10. Electronic Warfare Signature Measurement Facility (United States)

    Federal Laboratory Consortium — The Electronic Warfare Signature Measurement Facility contains specialized mobile spectral, radiometric, and imaging measurement systems to characterize ultraviolet,...

  11. Electronic Warfare Signature Measurement Facility (United States)

    Federal Laboratory Consortium — The Electronic Warfare Signature Measurement Facility contains specialized mobile spectral, radiometric, and imaging measurement systems to characterize ultraviolet,...

  12. Electronic Warfare in Operations (United States)


    through gamma radiation (at the short-wavelength end). It covers wavelengths from thousands of kilometers to a fraction of the size of an atom...INFORMATION FUSION EXCHANGE F-13. The Knowledge and Information Fusion Exchange (sometimes called KnIFE ) is a program sponsored by U.S. Joint Forces...Warfare Analysis Center, 7-9 K–L–M Knowledge and Information Fusion Exchange ( KnIFE ), F-13 lasers, directed energy and, A-7 leadership (element

  13. Modern Maritime Trade Warfare (United States)


    historically established method for conducting maritime trade warfare is Maritime Interdiction Operations ( MIO ). In the context of this paper, the...operating far from friendly shores. Accordingly, this tool would be most useful against nations with less capable navies. An advantage of MIO in...or collateral damage. 6 Large-scale MIO can be resource intensive and time consuming, and the U.S. Navy and Coast Guard have limited ships and

  14. The fragmentation pathways of protonated Amiton in the gas phase: towards the structural characterisation of organophosphorus chemical warfare agents by electrospray ionisation tandem mass spectrometry. (United States)

    Ellis-Steinborner, Simon; Ramachandran, Aravind; Blanksby, Stephen J


    Amiton (O,O-diethyl-S-[2-(diethylamino)ethyl] phosphorothiolate), otherwise known as VG, is listed in schedule 2 of the Chemical Weapons Convention (CWC) and has a structure closely related to VX (O-ethyl-S-(2-diisopropylamino)ethylmethylphosphonothiolate). Fragmentation of protonated VG in the gas phase was performed using electrospray ionisation ion trap mass spectrometry (ESI-ITMS) and revealed several characteristic product ions. Quantum chemical calculations provide the most probable structures for these ions as well as the likely unimolecular mechanisms by which they are formed. The decomposition pathways predicted by computation are consistent with deuterium-labeling studies. The combination of experimental and theoretical data suggests that the fragmentation pathways of VG and analogous organophosphorus nerve agents, such as VX and Russian VX, are predictable and thus ESI tandem mass spectrometry is a powerful tool for the verification of unknown compounds listed in the CWC.

  15. Abdominal bloating and irritable bowel syndrome like symptoms following microinstillation inhalation exposure to chemical warfare nerve agent VX in guinea pigs. (United States)

    Katos, Alexandre M; Conti, Michele L; Moran, Theodore S; Gordon, Richard K; Doctor, Bhupendra P; Sciuto, Alfred M; Nambiar, Madhusoodana P


    While assessing the methylphosphonothioic acid S-(2-(bis(1-methylethyl)amino)ethyl)O-ethyl ester (VX) induced respiratory toxicity and evaluating therapeutics against lung injury, we observed that the animals were experiencing abnormal swelling in the abdominal area. Nerve agent has been known to increase salivary, nasal and gastrointestinal secretion and cause diarrhea. This study was initiated to investigate the effect of VX on the gastrointestinal tract (GI) since abdominal pathology may affect breathing and contribute to the on going respiratory toxicity. The mid-abdominal diameter and the size of the lower left abdomen was measured before and after 27.3 mg/m3 VX exposure by microinstillation and at 30 min intervals up to 2 h post-VX exposure. Both VX and saline exposed animals exhibited a decrease in circumference of the upper abdomen, although the decrease was slightly higher in VX-exposed animals up to 1 h. The waist diameter increased slightly in VX-exposed animals from 60 to 90 min post-VX exposure but was similar to saline controls. The lower left abdomen near to the cecum, 6 cm below and 2cm to the right of the end of the sternum, showed an increase in size at 30-60 min that was significantly increased at 90-120 min post-VX exposure. In addition, VX-exposed animals showed loose fecal matter compared to controls. Necropsy at 24h showed an increased small intestine twisting motility in VX-exposed animals. Body tissue AChE assay showed high inhibition in the esophagus and intestine in VX-exposed animals indicating that a significant amount of the agent is localized to the GI following microinstillation exposure. These results suggest that microinstillatipn inhalation VX exposure induces gastrointestinal disturbances similar to that of irritable bowel syndrome and bloating.

  16. Measurement of breakthrough volumes of volatile chemical warfare agents on a poly(2,6-diphenylphenylene oxide)-based adsorbent and application to thermal desorption-gas chromatography/mass spectrometric analysis. (United States)

    Kanamori-Kataoka, Mieko; Seto, Yasuo


    To establish adequate on-site solvent trapping of volatile chemical warfare agents (CWAs) from air samples, we measured the breakthrough volumes of CWAs on three adsorbent resins by an elution technique using direct electron ionization mass spectrometry. The trapping characteristics of Tenax(®) TA were better than those of Tenax(®) GR and Carboxen(®) 1016. The latter two adsorbents showed non-reproducible breakthrough behavior and low VX recovery. The specific breakthrough values were more than 44 (sarin) L/g Tenax(®) TA resin at 20°C. Logarithmic values of specific breakthrough volume for four nerve agents (sarin, soman, tabun, and VX) showed a nearly linear correlation with the reciprocals of their boiling points, but the data point of sulfur mustard deviated from this linear curve. Next, we developed a method to determine volatile CWAs in ambient air by thermal desorption-gas chromatography (TD-GC/MS). CWA solutions that were spiked into the Tenax TA(®) adsorbent tubes were analyzed by a two-stage TD-GC/MS using a Tenax(®) TA-packed cold trap tube. Linear calibration curves for CWAs retained in the resin tubes were obtained in the range between 0.2pL and 100pL for sarin, soman, tabun, cyclohexylsarin, and sulfur mustard; and between 2pL and 100pL for VX and Russian VX. We also examined the stability of CWAs in Tenax(®) TA tubes purged with either dry or 50% relative humidity air under storage conditions at room temperature or 4°C. More than 80% sarin, soman, tabun, cyclohexylsarin, and sulfur mustard were recovered from the tubes within 2 weeks. In contrast, the recoveries of VX and Russian VX drastically reduced with storage time at room temperature, resulting in a drop to 10-30% after 2 weeks. Moreover, we examined the trapping efficiency of Tenax TA(®) adsorbent tubes for vaporized CWA samples (100mL) prepared in a 500mL gas sampling cylinder. In the concentration range of 0.2-2.5mg/m(3), >50% of sarin, soman, tabun, cyclohexylsarin, and HD were

  17. Toxicology and pharmacology of the chemical warfare agent sulfur mustard - a review. Final technical report, 29 September 1994-31 January 1995

    Energy Technology Data Exchange (ETDEWEB)

    Dacre, J.C.; Beers, R.; Goldman, M.


    Sulfur mustard is a poisonous chemical agent which exerts a local action on the eyes, skin and respiratory tissue with subsequent systemic action on the nervous, cardiac, and digestive and endocrine systems in man and laboratory animals causing lacrimation, malaise, anorexia, salivation, respiratory distress, vomiting, hyperexcitability, cardiac distress, and death. Sulfur mustard is a cell poison which causes disumption and impairment of a variety of cellular activities which are dependent upon a very specific integral relationship. These cytotoxic effects are manifested in widespread metabolic disturbances whose variable characteristics are observed in enzymatic deficiencies, vesicant action, abnormal mitotic activity and cell division, bone marrow disruption, disturbances in hematopoietic activity and systemic poisoning. Indeed, mustard gas readily combines with various components of the cell such as amino acids, amines and proteins. Sulfur mustard has been shown to be mainly a lung carcinogen in various test animal species; this effect is highly dependent of size of the dose and the route of exposure. In the human, there is evidence of cancers of the respiratory tract in men exposed to mustard gas. Mutagenicity of sulfur mustard, due to the strong alkylating activity, has been reported to occur in many different species of animals, plants, bacteria, and fungi. There is no strong evidence that sulfur mustard is a teratogen but much further research, with particular emphasis on maternal and fetal toxicity, is needed and recommended.

  18. An isomer-specific high-energy collision-induced dissociation MS/MS database for forensic applications: a proof-of-concept on chemical warfare agent markers. (United States)

    Subramaniam, Raja; Östin, Anders; Nygren, Yvonne; Juhlin, Lars; Nilsson, Calle; Åstot, Crister


    Spectra database search has become the most popular technique for the identification of unknown chemicals, minimizing the need for authentic reference chemicals. In the present study, an isomer-specific high-energy collision-induced dissociation (CID) MS/MS spectra database of 12 isomeric O-hexyl methylphosphonic acids (degradation markers of nerve agents) was created. Phosphonate anions were produced by the electrospray ionization of phosphonic acids or negative-ion chemical ionization of their fluorinated derivatives and were analysed in a hybrid magnetic-sector-time-of-flight tandem mass spectrometer. A centre-of-mass energy (E(com)) of 65 eV led to an optimal sequential carbon-carbon bond breakage, which was interpreted in terms of charge remote fragmentation. The proposed mechanism is discussed in comparison with the routinely used low-energy CID MS/MS. Even-mass (odd-electron) charge remote fragmentation ion series were diagnostic of the O-alkyl chain structure and can be used to interpret unknown spectra. Together with the odd-mass ion series, they formed highly reproducible, isomer-specific spectra that gave significantly higher database matches and probability factors (by 1.5 times) than did the EI MS spectra of the trimethylsilyl derivatives of the same isomers. In addition, ionization by negative-ion chemical ionization and electrospray ionization resulted in similar spectra, which further highlights the general potential of the high-energy CID MS/MS technique.

  19. Effectiveness and reaction networks of H2O2 vapor with NH3 gas for decontamination of the toxic warfare nerve agent, VX on a solid surface. (United States)

    Gon Ryu, Sam; Wan Lee, Hae


    The nerve agent, O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate (VX) must be promptly eliminated following its release into the environment because it is extremely toxic, can cause death within a few minutes after exposure, acts through direct skin contact as well as inhalation, and persists in the environment for several weeks after release. A mixture of hydrogen peroxide vapor and ammonia gas was examined as a decontaminant for the removal of VX on solid surfaces at ambient temperature, and the reaction products were analyzed by gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectrometry (NMR). All the VX on glass wool filter disks was found to be eliminated after 2 h of exposure to the decontaminant mixtures, and the primary decomposition product was determined to be non-toxic ethyl methylphosphonic acid (EMPA); no toxic S-[2-(diisopropylamino)ethyl] methylphosphonothioic acid (EA-2192), which is usually produced in traditional basic hydrolysis systems, was found to be formed. However, other by-products, such as toxic O-ethyl S-vinyl methylphosphonothioate and (2-diisopropylaminoethyl) vinyl disulfide, were detected up to 150 min of exposure to the decontaminant mixture; these by-products disappeared after 3 h. The two detected vinyl byproducts were identified first in this study with the decontamination system of liquid VX on solid surfaces using a mixture of hydrogen peroxide vapor and ammonia gas. The detailed decontamination reaction networks of VX on solid surfaces produced by the mixture of hydrogen peroxide vapor and ammonia gas were suggested based on the reaction products. These findings suggest that the mixture of hydrogen peroxide vapor and ammonia gas investigated in this study is an efficient decontaminant mixture for the removal of VX on solid surfaces at ambient temperature despite the formation of a toxic by-product in the reaction process.

  20. A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides

    Energy Technology Data Exchange (ETDEWEB)

    Wilhelm, Christina M., E-mail: [Battelle, 505 King Avenue, JM-7, Columbus, OH 43201-2693 (United States); Snider, Thomas H., E-mail: [Battelle, 505 King Avenue, JM-7, Columbus, OH 43201-2693 (United States); Babin, Michael C., E-mail: [Battelle, 505 King Avenue, JM-7, Columbus, OH 43201-2693 (United States); Jett, David A., E-mail: [National Institutes of Health/National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 (United States); Platoff, Gennady E., E-mail: [National Institutes of Health/National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 (United States); Yeung, David T., E-mail: [National Institutes of Health/National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 (United States)


    The currently fielded pre-hospital therapeutic regimen for the treatment of organophosphorus (OP) poisoning in the United States (U.S.) is the administration of atropine in combination with an oxime antidote (2-PAM Cl) to reactivate inhibited acetylcholinesterase (AChE). Depending on clinical symptoms, an anticonvulsant, e.g., diazepam, may also be administered. Unfortunately, 2-PAM Cl does not offer sufficient protection across the range of OP threat agents, and there is some question as to whether it is the most effective oxime compound available. The objective of the present study is to identify an oxime antidote, under standardized and comparable conditions, that offers protection at the FDA approved human equivalent dose (HED) of 2-PAM Cl against tabun (GA), sarin (GB), soman (GD), cyclosarin (GF), and VX, and the pesticides paraoxon, chlorpyrifos oxon, and phorate oxon. Male Hartley guinea pigs were subcutaneously challenged with a lethal level of OP and treated at approximately 1 min post challenge with atropine followed by equimolar oxime therapy (2-PAM Cl, HI-6 DMS, obidoxime Cl{sub 2}, TMB-4, MMB4-DMS, HLö-7 DMS, MINA, and RS194B) or therapeutic-index (TI) level therapy (HI-6 DMS, MMB4-DMS, MINA, and RS194B). Clinical signs of toxicity were observed for 24 h post challenge and blood cholinesterase [AChE and butyrylcholinesterase (BChE)] activity was analyzed utilizing a modified Ellman's method. When the oxime is standardized against the HED of 2-PAM Cl for guinea pigs, the evidence from clinical observations, lethality, quality of life (QOL) scores, and cholinesterase reactivation rates across all OPs indicated that MMB4 DMS and HLö-7 DMS were the two most consistently efficacious oximes. - Highlights: • First comprehensive evaluation of leading AChE oxime reactivators • All oximes are compared against current U.S. therapy 2-PAM Cl. • Relative therapeutic oxime efficacies against OP CWNA and pesticides • Contribution to more effective

  1. Establishing Cyber Warfare Doctrine

    Directory of Open Access Journals (Sweden)

    Andrew M. Colarik


    Full Text Available Over the past several decades, advances in technology have transformed communications and the ability to acquire, disseminate, and utilize information in a range of environments. Modern societies and their respective militaries have taken advantage of a robust information space through network-centric systems. Because military and commercial operations have increasingly converged, communication and information infrastructures are now high-priority military objectives in times of war. This article examines the theoretical underpinning of current cyber warfare research, what we have learned so far about its application, and some of the emerging themes to be considered; it also postulates the development of a (national cyber warfare doctrine (CWD. An endeavor of this scale requires lots of considerations and preparation for its development if it is to be cooperatively embraced. This article considers why information technology systems and their supporting infrastructures should be considered legitimate military targets in conflicts, and offers several events that support this supposition. In addition, it identifies the various forms of doctrine that will become the basis for developing a CWD, discusses a CWD's possible components, and proposes a national collaborative and discussion framework for obtaining a nation's stakeholder buy-in for such an endeavor.

  2. Decontamination of Water Containing Radiological Warfare Agents (United States)


    fission, Stagg Stadium, University of Chicago. 16 Jul 45 - Alamagordo, New Mexico TRINITY shot, 19 kt. 5 Aug 45 - "Little Boy" atom bomb, Hliroshima...of New Mexico nuclear age. Nevada Test Site Nuclear 100 ki 4,700 shot Sedan - largest continental shot. Novaya Zemlya (USSR) Nuclear 50 u10 39,000...muultipurpose uInit capalli’ of producilg potable drinking water tromin •%haltev er ra%% water source may lie available. The rev•,rse sismos (1Ito

  3. Laboratory Aspects of Biological Warfare Agents (United States)


    in cell-free media. The medium, acidified citrate cysteine medium [ACCM; citric acid /sodium citrate, L-cysteine, neopeptone, casamino acids ...Capable of normal completion of life cycle . Viral coat protein - A protein present in the layer surrounding the nucleic acid core of a virus...19 Nucleic Acid

  4. Airpower Support to Unconventional Warfare (United States)


    supplies to isolated mountain outposts (Trest 2000, 109). The Helio Couriers operated out of small dirt strips, referred to as lima sites, usually... rosa : The O.S.S. and American espionage. New York: Reynal and Hitchcock. AF Special Operations Command white paper. 2007. USAF irregular warfare...Symposium on the role of airpower in counterinsurgency and unconventional warfare: A brief summary of viewpoints. Santa Monica, CA: The RAND

  5. Understanding the elementary considerations in a network warfare environment: an introductory framework

    CSIR Research Space (South Africa)

    Veerasamy, N


    Full Text Available framework. 5.1 Constrains and Implications Several factors can constrain network warfare and have associated consequences. These include the legal issues, ethical dilemmas, technical solutions, financial impact and skill/manpower investment. Logical... the personality traits of an individual. Users will need to balance ethical dilemmas before engaging in offensive network warfare. Computers and network are powerful tools and great harm can be caused with them. Motive, attitude, values, upbringing, experience...

  6. ISIL's Hybrid Warfare in Syria & Iraq

    DEFF Research Database (Denmark)

    Sørensen, Heine


    The case study specifically seeks to answer the following problem statement: Does ISIL qualify as an actor using hybrid warfare and if so what characterizes their particular use of this type of warfare? Based on an analysis of ISIL’s warfare from August 2012 to August 2016 the chapter argues, tha...

  7. The ethics of drone warfare

    Directory of Open Access Journals (Sweden)

    Fatić Aleksandar


    Full Text Available The paper investigates the compatibility of the modern technologies of warfare, specifically the use of offensive drones, with traditional military ethics and suggests that the new technologies radically change the value system of the military in ways which make large parts of the traditional military ethics inapplicable. The author suggests that Agamben’s concept of ‘effectivity’ through ‘special actions’ which mark one’s belonging to a particular community or profession is a useful conceptual strategy to explore the compatibility of drone warfare with traditional military ethics; this strategy shows mixed results at best.

  8. The Anatomy of Counterinsurgency Warfare

    DEFF Research Database (Denmark)

    Ringsmose, Jens; Pedersen, Kenneth

    Since the beginning of the new millennium, the West has been increasingly involved in a tiresome and rather particular type of conflict: insurgency warfare. The bloody and shocking terrorist attacks on New York and Washington in September 2001 marked the beginning of a new era, and the introducti...

  9. Evolutionary Models of Irregular Warfare (United States)


    G. (2010) Decentralize, adapt and cooperate. Nature 465:292-293. Sagarin, R. (2012) Learning From the Octopus : How Secrets from Nature Can Help Us...because the concepts map on to important features of modern irregular warfare. For example, small-scale behaviors are increasingly thought to

  10. Cutaneous reactions in nuclear, biological and chemical warfare

    Directory of Open Access Journals (Sweden)

    Arora Sandeep


    Full Text Available Nuclear, biological and chemical warfare have in recent times been responsible for an increasing number of otherwise rare dermatoses. Many nations are now maintaining overt and clandestine stockpiles of such arsenal. With increasing terrorist threats, these agents of mass destruction pose a risk to the civilian population. Nuclear and chemical attacks manifest immediately while biological attacks manifest later. Chemical and biological attacks pose a significant risk to the attending medical personnel. The large scale of anticipated casualties in the event of such an occurrence would need the expertise of all physicians, including dermatologists, both military and civilian. Dermatologists are uniquely qualified in this respect. This article aims at presenting a review of the cutaneous manifestations in nuclear, chemical and biological warfare and their management.


    Directory of Open Access Journals (Sweden)

    Dan-Iulian VOITAȘEC


    Full Text Available According to the Declaration of Saint Petersburg of 1868 “the only legitimate object which States should endeavor to accomplish during war is to weaken the military forces of the enemy”. Thus, International Humanitarian Law prohibits or limits the use of certain means and methods of warfare. The rapid development of technology has led to the emergence of a new dimension of warfare. The cyber aspect of armed conflict has led to the development of new means and methods of warfare. The purpose of this paper is to study how the norms of international humanitarian law apply to the means and methods of cyber warfare.

  12. Cyber warfare building the scientific foundation

    CERN Document Server

    Jajodia, Sushil; Subrahmanian, VS; Swarup, Vipin; Wang, Cliff


    This book features a wide spectrum of the latest computer science research relating to cyber warfare, including military and policy dimensions. It is the first book to explore the scientific foundation of cyber warfare and features research from the areas of artificial intelligence, game theory, programming languages, graph theory and more. The high-level approach and emphasis on scientific rigor provides insights on ways to improve cyber warfare defense worldwide. Cyber Warfare: Building the Scientific Foundation targets researchers and practitioners working in cyber security, especially gove

  13. Roots of Russian Irregular Warfare (United States)


    concluded that the United States has a national policy gap in our own ability to wage “unconventional warfare in the gray zone.”3 That statement...advancing army—few have studied the irregular nature of the campaign waged against Napoleon. Napoleon’s overstretched logistics and the elusiveness of...94 Karl E. Meyer and Shareen Blair Brysac, Tournament of Shadows: The Great Game and the Race for Empire in Central Asia (Washington, DC: Basic

  14. Rethinking Cultural Influences on Warfare (United States)


    militaries turn toward understanding culture as an important corrective action to naive ethnocentrism , but warns about the dangers of... Ethnocentrism (Holmes and Meier, 1979); Robert E. Harkavy and Stephanie G. Neuman, Warfare in the Third World (Palgrave, 2001); more recently, Mary...influence of ethnocentrism and the mirror imaging of our cultural values on to another culture with its own history. Scholars according to John Ferris

  15. Air Power in Irregular Warfare (United States)


    Intelligence, Surveillance, and Reconnaisance IW Irregular Warfare JFC Joint Force Commander JP Joint Publication xii MCP Malayan Communist Party...being or acting in accord with laws , rules, or established custom.”5 Combined with the Clausewitzian definition of war as “an act of violence meant...Quarterly and Defence Journal , October, 1920), accessed March 21, 2012,, 17. 22 Bruce

  16. Electronic warfare target location methods

    CERN Document Server

    Poisel, Richard


    Describing the mathematical development underlying current and classical methods of geolocating electronic systems that are emitting, this newly revised and greatly expanded edition of a classic Artech House book offers practical guidance in electronic warfare target location. The Second Edition features a wealth of additional material including new chapters on time delay estimation, direction finding techniques, and the MUSIC algorithm. This practical resource provides you with critical design information on geolocation algorithms, and establishes the fundamentals of existing algorithms as a

  17. Strategic Implications of Intercommunal Warfare in Iraq (United States)


    effect of events in Saudi Arabia. Thus Doha is somewhat inoculated from the immediate problems of an Iraqi civil war, although it may face internal and...with federalism in multinational states, see Ramon Maiz , “Democracy, Federalism, and Nationalism in 44 Multinational States,” in Identity and...Territorial Autonomy in Plural Societies, William Safran and Ramon Maiz , eds., London: Frank Cass, 2000, pp. 34-60. 43. Chris Kutschera, “An Island of

  18. Legislation regulating the Colombian health system: formulation, implementation and implications on its agents

    Directory of Open Access Journals (Sweden)

    Iván F. Muñoz E


    Full Text Available In the Colombian health system, the legislation complies with the role of determining its structure and function in order to guarantee the rights to health and social security included in the 1991 Constitution. Objective: to present the issues in the formulation and implementation of legislation in the current system and the implications of their various agents. Methodology: a study in six Colombian cities using qualitative methodology based on the theory. 174 interviews were conducted with doctors, administrators, nurses and users. Results: the findings reveal problems in the formulation and implementation, including: over-regulation and the difficulties of his apprehension, the influence of special interests and not matching the standards with the needs of the population health. Discussion: these problems cause barriers to accessing health services and failures in the quality of patient care, ethical dilemmas and dissatisfaction with health professionals, as well as instability in the health sector institutions. This emerges as a constraint to guarantee the right to health and requires a rethinking of the law in favor of the constitutional principles and the collective welfare.

  19. Russia’s Approach to Cyber Warfare (United States)


    psychological operations, and information operations. • In keeping with traditional Soviet notions of battling constant threats from abroad and within...theorists, is a holistic concept that includes computer network operations, electronic warfare, psychological operations, and information operations.3...that “in the ongoing revolution in information technologies, information and psychological warfare will largely lay the groundwork for victory.”10

  20. Chemical and biological warfare: Detection and warning systems. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)



    The bibliography contains citations concerning the detection, identification, verification, and warning systems of chemical and biological warfare agents. Citations discuss agents sampling, monitoring, and assessment. Techniques include chromotography, biosensing, chemical analysis, and DNA probes. Land pollution, soil tests, and skin protection are examined. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  1. Chemical and biological warfare: Biology, chemistry, and toxicology. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)



    The bibliography contains citations concerning the physiological effects, physicochemical effects, and toxicology of chemical and biological warfare agents. Citations discuss toxic chemicals, chemical agent simulants, detoxification and decontamination, environmental toxicity, and land pollution. Detection techniques and warning systems are examined in a separate bibliography. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  2. Chemical and biological warfare: Biology, chemistry, and toxicology. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)



    The bibliography contains citations concerning the physiological effects, physicochemical effects, and toxicology of chemical and biological warfare agents. Citations discuss toxic chemicals, chemical agent simulants, detoxification and decontamination, environmental toxicity, and land pollution. Detection techniques and warning systems are examined in a separate bibliography. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  3. Women and Warfare in Pre-Colonial Akokoland

    Directory of Open Access Journals (Sweden)

    Olusanya Faboyede


    Full Text Available In pre-colonial Akokoland, the most conspicuous fact about its political economy and peace was security challenges and mismanagement through internal and external manipulation. This paper analyses the role of women in warfare in pre-colonial Akokoland as a potential to integrate Akokoland, a multi-cultural community for productive and sustained effort to promote economic development in the region. Thus, the paper is conceptualised on historical objectivity. The paper argues that one of the ways of dealing with the scale of insecurity in the society is to assimilate historical thinking into the intention of the security agents (women warriors.

  4. The Art of Aerial Warfare (United States)


    the  Strait  of  Gibraltar   from  North  Africa  during  the Spanish Civil War. 11 FAIRCHILD PAPER A Comparison of Aerial Warfare to Land... Hitler , for example, the United States cannot assume that Nazi aggression would have  evaporated  instantly. Although  Hitler himself profoundly affected


    Directory of Open Access Journals (Sweden)

    Laurian GHERMAN


    Full Text Available The paper is focused on changes occurred in military organizations in Information Age. During Industrial Age the military structure of forces evolved according with principles of decomposition, specialization, hierarchy, optimization, deconfliction, centralized planning, and decentralized execution. But now the solutions based upon Industrial Age assumptions and practices will break down and fail in the Information Age. This will happen no matter how well intentioned, hardworking, or dedicated the leadership and the force are. Two key force capabilities needed by Information Age militaries are interoperability and agility. Both interoperability and agility are provided by Network centric warfare theory of war.

  6. Information warfare technologies in political discourse

    Directory of Open Access Journals (Sweden)

    Karpova Anna Yu.


    Full Text Available We attempt to examine the technology of «information warfare» in this paper. The dominant theme of the paper is that the outcome of the information warfare is important not only for the future of a state itself but for the future of the world balance of forces. The main task of geopolitical actors in information warfare is to introduce ideas corresponding to their interests into mass consciousness. All participants of political conflicts have common features in technologies of Information warfare. The information anomie is the indicator of the great geopolitical actors’ personified interests on the stage of «information warfare» - the process resulted in destroying the communicative line: report-information understanding and disrupting the social order in society. In this paper authors describe the following Information Warfare technologies: "Political volcano" technology; "SPIN" technology; "Widening media resource" technology; "specific gravity" technology; "Cold War 2.0" technology and Information cleaningup technology. It is assumed that in the future there will be new instructions on applying technologies of information warfare. To impart perspective to the paper we consider examples, opinions and trends.

  7. History of biological warfare and bioterrorism. (United States)

    Barras, V; Greub, G


    Bioterrorism literally means using microorganisms or infected samples to cause terror and panic in populations. Bioterrorism had already started 14 centuries before Christ, when the Hittites sent infected rams to their enemies. However, apart from some rare well-documented events, it is often very difficult for historians and microbiologists to differentiate natural epidemics from alleged biological attacks, because: (i) little information is available for times before the advent of modern microbiology; (ii) truth may be manipulated for political reasons, especially for a hot topic such as a biological attack; and (iii) the passage of time may also have distorted the reality of the past. Nevertheless, we have tried to provide to clinical microbiologists an overview of some likely biological warfare that occurred before the 18th century and that included the intentional spread of epidemic diseases such as tularaemia, plague, malaria, smallpox, yellow fever, and leprosy. We also summarize the main events that occurred during the modern microbiology era, from World War I to the recent 'anthrax letters' that followed the World Trade Center attack of September 2001. Again, the political polemic surrounding the use of infectious agents as a weapon may distort the truth. This is nicely exemplified by the Sverdlovsk accident, which was initially attributed by the authorities to a natural foodborne outbreak, and was officially recognized as having a military cause only 13 years later.

  8. Grid architecture model of network centric warfare

    Institute of Scientific and Technical Information of China (English)

    Yan Tihua; Wang Baoshu


    NCW(network centric warfare) is an information warfare concentrating on network. A global network-centric warfare architecture with OGSA grid technology is put forward, which is a four levels system including the user level, the application level, the grid middleware layer and the resource level. In grid middleware layer, based on virtual hosting environment, a BEPL4WS grid service composition method is introduced. In addition, the NCW grid service model is built with the help of Eclipse-SDK-3.0.1 and Bpws4j.

  9. Food Intake and Reward Mechanisms in Patients with Schizophrenia: Implications for Metabolic Disturbances and Treatment with Second-Generation Antipsychotic Agents

    National Research Council Canada - National Science Library

    Elman, Igor; Borsook, David; Lukas, Scott E


    ... $30.00www.neuropsychopharmacology.orgPerspectiveFood Intake and Reward Mechanisms in Patients with Schizophrenia: Implications for Metabolic Disturbances and Treatment with Second-Generation Antipsychotic Agents...

  10. Evanescent planar waveguide detection of biological warfare simulants (United States)

    Sipe, David M.; Schoonmaker, Kenneth P.; Herron, James N.; Mostert, Michael J.


    An evanescent planar waveguide Mark 1.5 instrument was used to detect simulants of biological warfare agents; ovalbumin (OV), MS2 bacteriophage, BG, and Erwinia herbicola (EH). Polyclonal tracer antibodies were labeled with the fluorescent dye, Cy5. Discrete bands of polyclonal capture antibodies were immobilized to a polystyrene planar waveguide with molded integral lenses. An ST-6 CCD camera was used for detection. OV. MS2 and BG were detected in a simultaneous 3 by 3 array; with a total of nine measurements within 6 minutes. EH was analyzed in a separate array. Results were evaluate dat the US Army Joint Field Trials V, at the Dugway Proving Grounds. Over a 10 day period, 32 unknown samples were analyzed daily for each simulant. Detection limits: OV 10 ng/ml, MS2 107 pfu/ml, BG 105 cfu/ml. EH was detectable at 5 X 105 cfu/ml. Overall false positives were 3.0 percent. Therefore, the Mark 1.5 instrument, with a parallel array of detectors, evanescent flourescent excitation, and CCD imaging provides for rapid, sensitive, and specific detection of biological warfare agent simulants.

  11. A Taxonomy of Network Centric Warfare Architectures (United States)


    Distributed Database Theory, an area of Computer Science that has studied information flow in networks extensively ( Ceri & Pelagatti 1984, Mullender 1993...Australian Department of Defence, 2003, Australian Defence Force Network Centric Warfare Roadmap (First Draft), September. Ceri , S. & Pelagatti

  12. Topic modelling in the information warfare domain

    CSIR Research Space (South Africa)

    De Waal, A


    Full Text Available In this paper the authors provide context to Topic Modelling as an Information Warfare technique. Topic modelling is a technique that discovers latent topics in unstructured and unlabelled collection of documents. The topic structure can be searched...

  13. A Dialectic for Network Centric Warfare (United States)


    Giffin, 2003; Borgu , 2003; Kaufman, 2004). For example, from a standpoint of Popperian methodological falsificationism (Popper, 1934), Reid and...focused term network-centric warfare has common favor ( Borgu , 2003) despite the organisational decree to use the term ‘network centric warfare...Commonwealth Department of Defence, June. Borgu , A., (2003), “The Challenges and Limitations of Network Centric Warfare”, Presented at NCW: Improving ADF

  14. Finding Lawrence recruiting talent for unconventional warfare


    Mourouzis, Michael G.


    Approved for public release; distribution is unlimited. From Francis Marion's guerrilla war against the British to advising the resistance against the Nazis and Japanese, the United States has depended on unconventional warfare (UW) as a component of national defense. Today, the U.S. Army Special Forces (SF) is the premiere unconventional warfare unit in the U.S. military. With a smaller Army and increasing missions, SF must expand its recruiting efforts. This thesis analyzes the recruitme...

  15. Cyber Warfare: New Character with Strategic Results (United States)


    defense ( CND ).”7 Thus cyber warfare is distinguished from cyber criminal acts based upon its coercive nature to attain a strategic end, whereas...CNA and CND . Conceptually, CNA effects “range from disrupting the adversary’s electronic systems and what operations they enable (communications...or self-destruct.”10 The second component of cyber warfare seeks to eliminate or minimize the risk of the first. The role of CND is to defend

  16. UML modelling of network warfare examples

    CSIR Research Space (South Africa)

    Veerasamy, N


    Full Text Available , Analysis, Development and Maintenance [6] [12] [13]. Furthermore, Baker and Harris also discuss techniques like Intrusion Prevention, Personnel Security and Security Awareness as part of information security [14] [12]. Moreover, when considering... techniques that are core to information security and to Network Warfare were thus identified. The following summary of the techniques found in Network Warfare is given: Risk Analysis, Intrusion Prevention, Physical Security, Personnel Security, Cyber...

  17. Inversion recovery measurements in the presence of radiation damping and implications for evaluating contrast agents in magnetic resonance. (United States)

    Eykyn, Thomas R; Payne, Geoffrey S; Leach, Martin O


    Relaxation measurements performed at high magnetic field in magnetic resonance (MR) may be adversely affected by the influence of radiation damping in concentrated samples such as water. We consider how the measured value of T1 is affected by this phenomenon for a gadolinium-doped water sample and for an undoped water sample and consider the implications for evaluating contrast agents. A simple method involving the application of a pulsed field gradient to de-phase residual transverse components of the magnetization is shown to be an effective method for suppressing this effect. Given the central role that measurement of the T1 of water plays in the assessment of contrast agents as well as a host of other MR applications, care should always be employed when measuring and interpreting T1 measurements at high magnetic fields.

  18. Intrafamily and intragenomic conflicts in human warfare (United States)


    Recent years have seen an explosion of multidisciplinary interest in ancient human warfare. Theory has emphasized a key role for kin-selected cooperation, modulated by sex-specific demography, in explaining intergroup violence. However, conflicts of interest remain a relatively underexplored factor in the evolutionary-ecological study of warfare, with little consideration given to which parties influence the decision to go to war and how their motivations may differ. We develop a mathematical model to investigate the interplay between sex-specific demography and human warfare, showing that: the ecology of warfare drives the evolution of sex-biased dispersal; sex-biased dispersal modulates intrafamily and intragenomic conflicts in relation to warfare; intragenomic conflict drives parent-of-origin-specific patterns of gene expression—i.e. ‘genomic imprinting’—in relation to warfare phenotypes; and an ecological perspective of conflicts at the levels of the gene, individual, and social group yields novel predictions as to pathologies associated with mutations and epimutations at loci underpinning human violence. PMID:28228515

  19. Nontherapeutic Use of Antimicrobial Agents in Animal Agriculture: Implications for Pediatrics. (United States)

    Paulson, Jerome A; Zaoutis, Theoklis E


    Antimicrobial resistance is one of the most serious threats to public health globally and threatens our ability to treat infectious diseases. Antimicrobial-resistant infections are associated with increased morbidity, mortality, and health care costs. Infants and children are affected by transmission of susceptible and resistant food zoonotic pathogens through the food supply, direct contact with animals, and environmental pathways. The overuse and misuse of antimicrobial agents in veterinary and human medicine is, in large part, responsible for the emergence of antibiotic resistance. Approximately 80% of the overall tonnage of antimicrobial agents sold in the United States in 2012 was for animal use, and approximately 60% of those agents are considered important for human medicine. Most of the use involves the addition of low doses of antimicrobial agents to the feed of healthy animals over prolonged periods to promote growth and increase feed efficiency or at a range of doses to prevent disease. These nontherapeutic uses contribute to resistance and create new health dangers for humans. This report describes how antimicrobial agents are used in animal agriculture, reviews the mechanisms of how such use contributes to development of resistance, and discusses US and global initiatives to curb the use of antimicrobial agents in agriculture.

  20. Responses of dispersal agents to tree and fruit traits in Virola calophylla (Myristicaceae): implications for selection. (United States)

    Russo, Sabrina E


    Variation in traits affecting seed dispersal in plants has been attributed to selection exerted by dispersal agents. The potential for such selection was investigated in Virola calophylla (Myristicaceae) in Manú National Park, Peru, through identification of seed dispersal agents and of tree and fruit traits significantly affecting the quantity of seeds dispersed. Seventeen bird and one primate species (the spider monkey, Ateles paniscus) dispersed its seeds. Spider monkeys dispersed the majority of seeds (a minimum of 83% of all dispersed seeds). Visitation by dispersal agents depended only on the quantity of ripe fruit available during a tree observation. In contrast, seed removal increased with both greater quantity of ripe fruit and aril: seed ratio. When analyzed separately, seed removal by birds increased only with greater aril: seed ratio, whereas seed removal by spider monkeys was affected by the quantity of ripe fruit and phenological stage. The finding that dispersal agents responded differently to some tree and fruit traits indicates not only that dispersal agents can exert selection on traits affecting seed dispersal, but also that the resulting selection pressures are likely to be inconsistent. This conclusion is supported by the result that the proportion of the seed crop that was dispersed from individual trees, which accounted for cumulative dispersal by all agents, was not influenced by any tree or fruit trait evaluated. Comparing these results with those from studies of V. sebifera and V. nobilis in Panama revealed that the disperser assemblages of these three Virola species were congruent in their similar taxonomic representation. In Panama the proportion of V. nobilis seed crop dispersed was related positively to aril: seed ratio and negatively to seed mass, a result not found for V. calophylla in Peru. The greater importance of dispersal by primates versus birds in V. calophylla, relative to V. nobilis, may explain this difference. Thus

  1. Towards a framework for a network warfare capability

    CSIR Research Space (South Africa)

    Veerasamy, N


    Full Text Available aspects to its network enabled capabilities and functionality (network warfare). Various computer and information security practices form part of network warfare techniques. Whilst various information and security practices are well-known and applied...

  2. Integrated Assessment Systems for Chemical Warfare Material

    Energy Technology Data Exchange (ETDEWEB)

    A. M. Snyder; D. A. Verrill; G. L. Thinnes; K. D. Watts; R. J. McMorland


    The US Army must respond to a variety of situations involving suspect discovered, recovered, stored, and buried chemical warfare materiel (CWM). In some cases, the identity of the fill materiel and the status of the fusing and firing train cannot be visually determined due to aging of the container, or because the item is contained in an over-pack. In these cases, non-intrusive assessments are required to provide information to allow safe handling, storage, and disposal of the materiel. This paper will provide an overview of the integrated mobile and facility-based CWM assessment system prototypes that have been, and are being developed, at the Idaho National Engineering and Environmental Laboratory (INEEL) for the US Army Non-Stockpile Chemical Materiel Project. In addition, this paper will discuss advanced sensors being developed to enhance the capability of the existing and future assessment systems. The Phase I Mobile Munitions Assessment System (MMAS) is currently being used by the Army's Technical Escort Unit (TEU) at Dugway Proving Ground, Utah. This system includes equipment for non-intrusively identifying the munitions fill materiel and for assessing the condition and stability of the fuzes, firing trains, and other potential safety hazards. The system provides a self-contained, integrated command post including an on-board computer system, communications equipment, video and photographic equipment, weather monitoring equipment, and miscellaneous safety-related equipment. The Phase II MMAS is currently being tested and qualified for use by the INEEL and the US Army. The Phase II system contains several new assessment systems that significantly enhance the ability to assess CWM. A facility-based munitions assessment system prototype is being developed for the assessment of CWM stored in igloos at Pine Bluff Arsenal, Arkansas. This system is currently in the design and fabrication stages. Numerous CWM advanced sensors are being developed and tested, and

  3. Evidence implicating Thamnostylum lucknowense as an etiological agent of Rhino-orbital Mucormycosis (United States)

    In this report, we present a case of rhino-orbital mucormycosis in a 57-year-old female with poorly controlled diabetes mellitus. The causal agent was cultured from a specimen of the nasal crust and identified phenotypically and independently using nuclear ribosomal DNA sequence data as Thamnostylum...

  4. Biological warfare in a historical perspective. (United States)

    Roffey, R; Tegnell, A; Elgh, F


    There are some early examples of biological warfare (BW), but in modern times it was used first for sabotage by Germany during WWI. Development of biological weapons on a military significant scale was initiated in several countries in the period between the world wars. During WWII, several countries had active programs such as the USA, UK, Canada, Germany, Japan and the Soviet Union. It was only Japan that on a fairly large scale used BW. The US program continued until 1969, when President Nixon took a decision to end it in connection with signing the BTWC. The Soviet Union had also continued its program after the war, and this was enhanced after signing the BTWC: in the 1980s the program consisted of around fifty facilities and involved around 60,000 people. The Soviet Union produced and maintained a large stockpile of BW-agents. After the collapse of the Soviet Union, and due to pressure from USA and UK, President Yeltsin issued a decree in 1992 banning continued offensive BW activity. However, there are still concerns of residual activity in Russia. Another program of concern is the Iraqi BW-program. After 10 years of UN inspections that were stopped in 1998, there are still many unanswered questions concerning the BW program. There was also a covert BW-program in South Africa that was terminated around 1993. There have also been a number of allegations of alleged use or possession. In addition, there are indications that 10-12 states are now trying to acquire BW, and this assessment is based on intelligence information, mainly from the USA. For example Iraq, North Korea, Iran, Syria, Sudan and Libya. Another aspect is the strong driving force of technology developments to promote this type of program, opening new risks for future potential military misuse.

  5. Hybrid Warfare: A Military Revolution or Revolution in Military Affairs? (United States)


    warfare intersect and blend to create a new form of warfare. This thesis uses the Williamson Murray and McGregor Knox definitions of Military...irregular warfare intersect and blend to create a new form of warfare. This thesis uses the Williamson Murray and McGregor Knox definitions of...understand new concepts. Douglas C Lovelace. Director Strategic Studies Institute has this insight to offer regarding the importance of

  6. Motivation and requirements for determining a Network Warfare Capability

    CSIR Research Space (South Africa)

    Veerasamy, N


    Full Text Available to prevent misconceptions, as well as to ensure that the necessary input data is incorporated. They include the following: • The involved parties must grasp the difference between auditing and determining a Network Warfare Capability. It is encouraged... to incorporate the use of auditing in the technique set underlying Network Warfare. • To determine a Network Warfare Capability, assessments of the various techniques that contribute to Network Warfare are necessary. This will incorporate expert opinion...

  7. Identification of the serotypes of bacterial meningitis agents; implication for vaccine usage.

    Directory of Open Access Journals (Sweden)

    Mohammad Mehdi Attarpour-Yazdi


    Full Text Available Bacterial meningitis is one of the most serious infections and should be treated as emergency. As it has significant morbidity and mortality throughout the world, every country should have precise information regarding the etiological agents of disease and populations at risk to design public health prevention strategy. In the present study in addition of evaluation of common etiological agents (Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae in bacterial meningitis cases, we sero-grouped or serotyped the obtained agents in order to predict the usefulness of existing vaccines against bacterial meningitis.Cerebrospinal fluid of 182 suspected meningitis patients were collected, from which 114 cases were approved by biochemical, microbiological and molecular tests as bacterial meningitis. The isolated bacteria were serogrouped or serotyped to determine the dominant serotypes.Streptococcus pneumoniae accounted for 36%, Haemophilus influenza for 26% and Neisseria meningitidis for 14% of cases. From 13 serogroups of N. meningitides the most frequent serogroups, were meningococcus group B (51%, C(24% A (18%, Z(2%, W135 (1% and 3% was not identified. In H. influenzae group only serotype b (100% have been identified and in pneumococcal meningitis the most common serotype among our cases were 18C (44% followed by14 (17%, 19A (13%, 6A (9%, 7F (4%, 4(3%, 3 (3%, 9V (2%, 8 (2%, 23f (2%, 5 (1%.Since there is no nationwide mass immunization program for common agents of bacterial meningitis in Iran, the result of this study can be used to improve the existing vaccines to cover the detected serotypes and consequently reduce the incidence of bacterial meningitis.

  8. Dramatic Expression in Opera, and Its Implications for Conversational Agents. Chapter 7 (United States)

    Johnson, W. Lewis


    This article has discussed principles, techniques, and methods of dramatic portrayal in opera, and their application to the development of embodied conversational agents. Investigations such as this complement studies of natural human behavior, and offer insights as to how to make such behavior understandable and interesting when adapted for use by embodied conversational agents. However, one should use caution in applying such lessons. The unique characteristics of computer-based media are still being identified and explored. In any case, one must always be careful about applying principles blindly to any artistic form. Such principles are post-hoc analysis of the intuitive skill of great artists; this was as true in Aristotle's day as it is today. We should not let structural principles stand in the way of injecting creativity into the design of ECAs. Opera at its best possesses an element of magic that is difficult to describe, much less analytically reconstruct. We can only hope to achieve a similar result with conversational agents.

  9. [The history of biological warfare]. (United States)

    Cohen, Amir; Robenshtok, Eyal; Rotman, Eran; Sagi, Rami


    Selected events in the history of biological weapons are highlighted to increase the physician's awareness of this crucial threat. The deliberate use of biological substances originated in antiquity and has pervaded the history of human wars throughout time until the 21th century. The history of biological warfare is difficult to assess because of a number of confounding factors. These include the difficulty in verification of allegation, the use of the threat of this weapon for propaganda purposes, the lack of microbiological or epidemiological data, and the incidence of natural occurring endemic or epidemic diseases during hostilities. Although it may be problematic to verify at times, the use of such weapons has not been limited to national armies or militia. Frustrated civilians, terrorists and even physicians have used biological substances to promote their interests. Today, the biological threat has become more serious. It's potency, cost-effectiveness, and the ability to manufacture and deploy it with little sophistication, or under the semblance of legitimate commercial endeavors, will ensure that biological weapons remain a constant threat to human health.

  10. Working on warfare-related sites. Review after 15 years and perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, U. [Umweltberatung und Planung, Kassel (Germany)


    Fifteen years ago, in 1988, in connection with the Second International TNO/BMFT-Congress for the first time sites contaminated due to armaments production were mentioned, caused by the results of the first systematic investigation of a former explosives production plant in Hessisch Lichtenau. The authors referred to another 72 large chemical armament production plants in the FRG and 39 in the GDR. At the Third International TNO/BMFT-Congress in 1990 the complex of problems were substantiated and at the same time more topics were added. The Federal Government of Germany named the following areas suspected of being warfare-related contaminated sites: former production plants, ammunition depots, defusing sites, demolition areas and firing ranges, disassembly plants and intermediate and final storage plants for conventional and chemical combat agents. Soil, water and air pollution could be caused by the following products: explosives, chemical warfare agents, incendiaries, smoke agents, propellants, additives, primary and waste products and residues from the destruction of combat agents. In 1995 the Federal Environmental Agency (UBA) presented the results of the national survey showing that there are 3240 suspected contaminated sites. In 1995 also began the soil clean-up at the warfare-related contaminated sites Stadtallendorf and Hessisch Lichtenau. 8 respectively 10 years after the beginning of the systematic investigations the first contaminated soil was removed and treated in a thermal plant. In the run-up several R and D projects funded by the Federal Government were carried out (Stadtallendorf: MOSAL = Model Remediation of Contaminated Sites, Hessisch Lichtenau: Joint project Biological Remediation of Warfare-Related Contamination). At these sites basics were worked out and technologies were put to the test which can be used for the remediation of other sites. (orig.)

  11. Formation of amide bonds without a condensation agent and implications for origin of life. (United States)

    Keller, M; Blöchl, E; Wächtershäuser, G; Stetter, K O


    Amide bonds are of central importance for biochemistry; in the guise of peptide bonds, they form the backbone of proteins. The formation of amide bonds without the assistance of enzymes poses a major challenge for theories of the origin of life. Enzyme-free formation of amide bonds between amino acids has been demonstrated in the presence of condensing agents such as cyanamide. Here we report the formation of amide bonds in aqueous solution in the absence of any condensing agent. We find that the formation of pyrite (FeS2) from FeS and H2S can provide the driving force for reductive acetylation of amino acids with mercaptoacetic acid (HSCH2COOH). The redox energy of pyrite formation permits the activation of the carboxylic acid group, which is converted to a species that reacts readily with amines. This process provides support for the chemo-autotrophic theory for the origin of life, in which pyrite formation supplies the energy source for the first autocatalytic reproduction cycle.

  12. Chemical and biological warfare: Protection, decontamination, and disposal. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)



    The bibliography contains citations concerning the means to defend against chemical and biological agents used in military operations, and to eliminate the effects of such agents on personnel, equipment, and grounds. Protection is accomplished through protective clothing and masks, and in buildings and shelters through filtration. Elimination of effects includes decontamination and removal of the agents from clothing, equipment, buildings, grounds, and water, using chemical deactivation, incineration, and controlled disposal of material in injection wells and ocean dumping. Other Published Searches in this series cover chemical warfare detection; defoliants; general studies; biochemistry and therapy; and biology, chemistry, and toxicology associated with chemical warfare agents.(Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  13. Chemical and biological warfare: Protection, decontamination, and disposal. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)



    The bibliography contains citations concerning the means to defend against chemical and biological agents used in military operations, and to eliminate the effects of such agents on personnel, equipment, and grounds. Protection is accomplished through protective clothing and masks, and in buildings and shelters through filtration. Elimination of effects includes decontamination and removal of the agents from clothing, equipment, buildings, grounds, and water, using chemical deactivation, incineration, and controlled disposal of material in injection wells and ocean dumping. Other Published Searches in this series cover chemical warfare detection; defoliants; general studies; biochemistry and therapy; and biology, chemistry, and toxicology associated with chemical warfare agents. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  14. Cognitive systems in electronic warfare (United States)

    Kulpa, Krzysztof; Szczepankiewicz, Michał; Żywek, Marcin; Malanowski, Mateusz; Misiurewicz, Jacek; Samczyński, Piotr


    Electronic warfare (EW) techniques were invented 70 years ago and are still being developed, all the time with a key role played by their operators. However, a human operator responds far too slowly for the on-going needs since to be adequate to current threats the EW system reaction should be within 1 ms or less. Too slow reaction defers an achievement of the objectives, and generally may lead to disclosure of the applied strategy and to waste of resources. Developing the adequate response to the threat is a multifaceted matter that requires considerable experience and knowledge on the one hand, and thorough observation of outcomes of the applied strategy on the other hand. Such action requires the use of not only intelligence but also more complex algorithms for automatic control than the classical ones, and it heavily builds on the experience. It is therefore a cognitive task in its nature, and a human operator acts naturally this way. Consequently, a proper training and experience gained are what really matters. As a result of tests and actions in EW the operator builds his own knowledge base, thus, gains a capability of responding to the known threats in a balanced way. New threats, however, are much more challenging since they should be handled as fast as possible but in a fresh and creative manner. To this end, adapting the algorithms of radar jamming protection for the new conditions of the battlefield is an example of such challenging tasks. At present, such adjustments are done in a long feedback loop when the operator, after recognizing the problem, notifies the equipment manufacturers, and then, their engineers work on required solutions accordingly. Thus, the reaction time is counted in years, not a single milliseconds or seconds. Speeding up the response time is therefore the key issue, and a solution to it would be feasible only when cognitive systems were used. A concept of such cognitive system is presented in this paper.

  15. Hypercalcemia and calcinosis in Florida horses: implication of the shrub, Cestrum diurnum, as the causative agent. (United States)

    Krook, L; Wasserman, R H; Shively, J N; Tashjian, A H; Brokken, T D; Morton, J F


    A chronic debilitating disease is described in Florida horses. There is progress weight loss and lameness of increasing severity. Plasma calcium is elevated to moderate or severe degree. Anatomical changes include dystrophic calcinosis of elastic tissues, viz. major arteries, tendons and ligaments. A generalized osteopetrosis is present and may be related to hypoparathyroidsim and hypercalcitoninism. The presence of Cestrum diurnum (day-blooming jessamine, day cestrum, wild jasmin) in areas accessible to affected animals, the observation that leaves of the plant were stripped in these areas, and the finding of a potent, active vitamin D-like substance in this plant constitute strong evidence that Cestrum diurnum is the agent causing the abnormalities of mineral metabolism.

  16. US Army Special Warfare. Its Origins: Psychological and Unconventional Warfare, 1941-1952 (United States)


    sug- F P _ _ 6 PSYCHOLOGICAL WARFARE IN WORLD WAR I! gestion of a single agency which would serve as a clearinghouse for all intelligence, as well as...organizations, communications, demoli- tions, organization and training of civilians for guerrilla warfare, para- chute jumping, and amphibious...General Bolte, Director, P&O, was reluctant to endorse this latter sug- gestion , indicating, "as he had indicated from time to time at other points

  17. Guiding Warfare to Reach Sustainable Peace

    DEFF Research Database (Denmark)

    Vestenskov, David; Drewes, Line

    The conference report Guiding Warfare to Reach Sustainable Peace constitutes the primary outcome of the conference It is based on excerpts from the conference presenters and workshop discussions. Furthermore, the report contains policy recommendations and key findings, with the ambition of develo...

  18. Agricultural Warfare and Bioterrorism using Invasive Species (United States)

    The chapter on Agricultural Warfare and Bioterrorism using Invasive Species is part of the book titled Pest Management and Phytosanitary Trade Barriers authored by Neil Heather (Australia) and Guy Hallman. The chapter attempts to briefly put the topic into context with phytosanitation. It presents...

  19. Information Warfare Arms Control: Risks and Costs (United States)


    legal system and the modern concept of arms control were able to provide for national and international collective security during the Cold War...information warfare presents many challenges that question their viability. The most significant challenges are to the international legal system , which


    Directory of Open Access Journals (Sweden)

    Graciela Aparecida Profeta


    Full Text Available Public infrastructure services have been offered by private companies with state participation through sectoral regulatory agencies. However, due the existence of typical problems of Agent-Principal relationship that sign these arrangements, there are questions related to efficient performance of these agencies. In this sense, the objective was to present and discuss the intrinsic characteristics of the performance of the regulatory agencies, and how they are susceptible to political influence and capture problems. It was concluded that despite authorities with financial and administrative independence, there are important points of laxity in the agencies acting regime, especially those ones linked to the nomination / appointment of certain directors from their government and to budget subordination. These aspects indicate the possibility of capture and political influence, which can affect the efficiency in the sector. However, despite lack of reformulation and law enforcement, the performance of the agencies is important for ensuring efficiency because the highway concessions sector in Brazil is concentrated and this may allow the opportunistic behavior of firms and governments at the time of bidding.

  1. Surface Decontamination of Blister Agents Lewisite, Sulfur ... (United States)

    Journal Article Sulfur mustard (HD) and Lewisite (L) are blister agents that have a high potential for terrorist use. Agent Yellow (HL) is the eutectic mixture of HD and L. Bench-scale testing was used to determine the residual amount of these chemical warfare agents remaining on three building materials coupons (wood, metal and glass) after application of various decontaminants (household bleach, full strength and dilute; hydrogen peroxide 3 % solution; and EasyDECON® DF200).

  2. Optimization of Graphene Sensors to Detect Biological Warfare Agents (United States)


    low-cost sensors. 1.2 Research Topic Manoor showed it is possible to detect Gram-positive and Gram-negative bacteria via antimicrobial peptides ...This unit was placed into copper etchant to dissolve the copper and leave a PMMA/graphene layer for transfer to a 500nm SiO2 layer on a circuit...electron transport properties, ssDNA binding properties, and simple production. The CVD copper growth method was used to grow the graphene for transfer

  3. Biodegradation of Organophosphate Chemical Warfare Agents by Activated Sludge (United States)


    0.5 g H3BO3, 0.3 g ZnSO4·7H2O, 0.24 g MnCl2·4H2O, 0.14 g CuSO4 ·5H2O, 0.06 g KI, 0.06 g Na2MoO4· 2H2O , 0.06 g CoCl2·6H2O, 0.06 g NiCl2·6H2O, and 0.06 g...g CaCl2· 2H2O , 0.6675 g KH2PO4 and 20mL of a trace element solution, adapted from Hesselmann et al. (1999). The trace element solution consisted of...the following (per liter of deionized water): 5.46 g citric acid, 4.0 g hippuric acid, 0.72 g Na3NTA· 2H2O , 0.3 g Na3EDTA·4H2O, 3.0 g FeCl3·6H2O

  4. Unconventional Warfare: A Mission Metamorphosis for the 21st Century? (United States)


    brigadier general and publish several more noted works on Mao and revolutionary warfare. See Samuel B. Giffith, Mao Tse-Tung on Guerrilla Warfare (New...and propagators of the faith. The bibles (in English translation) are Mao Tse-tung on Guerrilla Warfare by Brigadier General Samuel B. Griffith...Barnett, B. Hugh Tovar , and Richard H. Schultz eds., Special Operations in US Strategy (Washington, D.C.: US Government Printing Office, 1984), 2. 58

  5. Implications of nanoscale based drug delivery systems in delivery and targeting tubulin binding agent, noscapine in cancer cells. (United States)

    Chandra, Ramesh; Madan, Jitender; Singh, Prashant; Chandra, Ankush; Kumar, Pradeep; Tomar, Vartika; Dass, Sujata K


    Noscapine, a tubulin binding anticancer agent undergoing Phase I/II clinical trials, inhibits tumor growth in nude mice bearing human xenografts of breast, lung, ovarian, brain, and prostrate origin. The analogues of noscapine like 9-bromonoscapine (EM011) are 5 to 10-fold more active than parent compound, noscapine. Noscapinoids inhibit the proliferation of cancer cells that are resistant to paclitaxel and epothilone. Noscapine also potentiated the anticancer activity of doxorubicin in a synergistic manner against triple negative breast cancer (TNBC). However, physicochemical and pharmacokinetic (ED50˜300-600 mg/kg bodyweight) limitations of noscapine present hurdle in development of commercial anticancer formulations. Therefore, objectives of the present review are to summarize the chemotherapeutic potential of noscapine and implications of nanoscale based drug delivery systems in enhancing the therapeutic efficacy of noscapine in cancer cells. We have constructed noscapine-enveloped gelatin nanoparticles, NPs and poly (ethylene glycol) grafted gelatin NPs as well as inclusion complex of noscapine in β-cyclodextrin (β-CD) and evaluated their physicochemical characteristics. The Fe3O4 NPs were also used to incorporate noscapine in its polymeric nanomatrix system where molecular weight of the polymer governed the encapsulation efficiency of drug. The enhanced noscapine delivery using μPAR-targeted optical-MR imaging trackable NPs offer a great potential for image directed targeted delivery of noscapine. Human Serum Albumin NPs (150-300 nm) as efficient noscapine drug delivery systems have also been developed for potential use in breast cancer.

  6. Computational models of intergroup competition and warfare.

    Energy Technology Data Exchange (ETDEWEB)

    Letendre, Kenneth (University of New Mexico); Abbott, Robert G.


    This document reports on the research of Kenneth Letendre, the recipient of a Sandia Graduate Research Fellowship at the University of New Mexico. Warfare is an extreme form of intergroup competition in which individuals make extreme sacrifices for the benefit of their nation or other group to which they belong. Among animals, limited, non-lethal competition is the norm. It is not fully understood what factors lead to warfare. We studied the global variation in the frequency of civil conflict among countries of the world, and its positive association with variation in the intensity of infectious disease. We demonstrated that the burden of human infectious disease importantly predicts the frequency of civil conflict and tested a causal model for this association based on the parasite-stress theory of sociality. We also investigated the organization of social foraging by colonies of harvester ants in the genus Pogonomyrmex, using both field studies and computer models.

  7. Violence and Warfare in Precontact Melanesia

    Directory of Open Access Journals (Sweden)

    Stephen M. Younger


    Full Text Available Levels of interpersonal violence and warfare for 30 Melanesian societies at the time of contact with Europeans are estimated based on ethnographic and historical records. While violence was common in indigenous Melanesia, it was not ubiquitous and some societies experienced extended periods of internal and external peace. Interpersonal violence and warfare were correlated-when one occurred there was a high probability of finding the other. Violence was not dependent on total population. It was, however, higher for population density greater than 50 persons per square kilometer. Violence in Melanesia may have been stimulated by the large number of relatively small polities, many of which competed with one another for prestige and, in some cases, land.

  8. Mapping the Spread of Mounted Warfare

    Directory of Open Access Journals (Sweden)

    Peter Turchin


    Full Text Available Military technology is one of the most important factors affecting the evolution of complex societies. In particular, mounted warfare, the use of horse-riders in military operations, revolutionized war as it spread to different parts of Eurasia and Africa during the Ancient and Medieval eras, and to the Americas during the Early Modern period. Here we use a variety of sources to map this spread.

  9. New dimensions of the modern warfare

    Directory of Open Access Journals (Sweden)



    Full Text Available The huge scientific and technologic progress made by mankind during the last century has had an obvious impact on the military phenomenon. It is a common place to say that the present day wars do not look like the previous ones at all. The military are not the same as the one in former days either, whatever their national insignia on various uniforms. Hence, some questions require a clear and imperative answer. How has the contemporary war been changed? How has the 21 Century military prophile evolved? Which is the trigger of all these changes? What are the new concepts of the modern warfare? To all those questions we are trying to get an answer based on our personal experience gained during a couple of NATO missions and on the respective military doctrines and policies. Why both the military and the politicians are trying to avoid the term „war" by placing instead the much more innofensive syntagm of „military operations" and what are the main characteristics of the 3rd Millenium officer? These are some of the topics of this essay. Quite new military concepts experimented by the most powefull armed forces of the world, such as Effect Based Operations Approach, Network Based Warfare, Information Operations and Psychologiocal Operations will be also examined as pillars of the modern warfare.

  10. Intelligence and Electronic Warfare Operations (United States)


    states otherwise, masculine nouns and pronouns do not refer exclusively to men. FM 34-1 CHAPTER 1 I N T E L L I G E N C E A N D E L E C T R O N I...improves as HUMINT refocuses its efforts on the AO. Interrogation and document exploitation are examples of HUMINT operations. HUMINT collection may also...and CA support for rear operations. MDCI personnel and interrogators provide HUMINT to identify and help neutralize enemy agents, sympathizers, and

  11. Implications of a Reduction in the Hemoglobin Target in Erythropoiesis-Stimulating Agent-Treated Hemodialysis Patients

    Directory of Open Access Journals (Sweden)

    Timothy V. Nguyen


    Full Text Available Background: Patients treated with erythropoiesis-stimulating agents (ESAs to a hemoglobin (Hb level >12.0 g/dl have increased risk of multiple complications, including death. The optimal Hb target for ESA use has not been established. We hypothesized that reducing the target Hb would prevent levels >12 g/dl and lead to significant cost savings. Methods: Our target Hb range was reduced to 9–11 g/dl from 10–12 g/dl. Thirty-five chronic hemodialysis (HD patients received erythropoietin (EPO and intravenous iron from January to December 2009. Data analysis included: Hb level, EPO dose, transferrin saturation and ferritin levels. EPO was administered via subcutaneous injection weekly or twice weekly. Results: The mean monthly Hb level changed from 11.2 to 10.6 g/dl. The percentages of patients with mean Hb >10.0, 12.0 and 13.0 g/dl were 82 ± 6.5, 10 ± 5.6 and 1.8 ± 1.9%, respectively. Weekly EPO dose decreased from 9,500 to 5,600 units, a 40% reduction per dose per patient and costs. The savings exceeded USD 60,000 per year for 35 patients. More than 80% of patients had transferrin saturation >20% and ferritin >200 ng/ml throughout the entire period. Conclusions: Lowering the target Hb range to 9–11 g/dl in HD patients achieved quality anemia management, avoided values >12.0 g/dl and resulted in cost savings. A minimal reduction in quality of life and no change in cardiovascular morbidity or mortality would be expected. The study has important implications in the new American bundled reimbursement model.

  12. The Cycle of Warfare - Analysis of an Analytical Model

    DEFF Research Database (Denmark)

    Jensen, Mikkel Storm


    The abstract has the title: “The Cycle of Warfare - Analysis of an Analytical Model” The Cycle of Warfare is an analytical model designed to illustrate the coherence between the organization, doctrine and technology of a military entity and the influence of the surrounding society as expressed...

  13. Dirty Fighting: How to Counter Total Warfare Mentality (United States)


    DIRTY FIGHTING: HOW TO COUNTER TOTAL WARFARE MENTALITY A thesis presented to the Faculty of the U.S. Army Command Counter Total Warfare Mentality Approved by: , Thesis Committee Chair LTC Sandra J. Sanchez, MBA , Member Marlyn R. Pierce...

  14. Built to Outlast: Operational Approaches to Hybrid Warfare (United States)


    second evolutionary generation of warfare incorporating political, economic, social, and technical changes, and maneuver warfare. Much of this concept is...aligns itself with the emerging understanding of the world through nonlinear sciences, epistemological and ontological foundations.308 In this, Unified

  15. Nodes and Codes: The Reality of Cyber Warfare (United States)


    Options ‘Off the Table’ for US Response to Cyber Attacks,” Stars and Stripes, May 8, 2009. 34 Scott Shackelford , “From Nuclear War to Net War...whitepapers/warfare/redefining-role- information-warfare-chinese-strategy_896 (accessed February 18, 2012). Shackelford , Scott. “From Nuclear War to

  16. Combat Simulation Modeling in Naval Special Warfare Mission Planning. (United States)


    This thesis explores the potential role of combat simulation modeling in the Naval Special Warfare mission planning cycle. It discusses methods the tactical level. The thesis concludes by discussing additional applications of combat simulation modeling within the Naval Special Warfare community and makes recommendations for its effective and efficient implementation.

  17. Hybrid Warfare: Preparing for Future Conflict (United States)


    Fukuyama , Francis . “At the ‘End of History’ Still Stands Democracy.” The Wall Street Journal, 6 June 2014. is cultural instead of political (in the traditional Clausewitzian sense). 15 Hoffman is referring to Francis Fukuyama’s idea of “the end of...history,” as argued in his 1989 essay and subsequent book. Fukuyama first published an essay titled “The End of History” in the National Interest in

  18. Microwave receivers with electronic warfare applications

    CERN Document Server

    Tsui, James


    This book by the author of Digital Techniques for Wideband Receivers willbe like no other one on your book shelf as the definitive word on electronicwarfare (EW) receiver design and performance. Whether you are an EWscientist involved in the test and evaluation of EW receivers or a designerof RWR's and other EW-related receivers, Microwave Receivers withElectronic Warfare Applications is a handy reference through which you canperfect your technical art. Lucidly written, this book is a treatise on EWreceivers that is relevant to you if you are just looking for a top-levelinsight into EW receive

  19. Electronic warfare receivers and receiving systems

    CERN Document Server

    Poisel, Richard A


    Receivers systems are considered the core of electronic warfare (EW) intercept systems. Without them, the fundamental purpose of such systems is null and void. This book considers the major elements that make up receiver systems and the receivers that go in them.This resource provides system design engineers with techniques for design and development of EW receivers for modern modulations (spread spectrum) in addition to receivers for older, common modulation formats. Each major module in these receivers is considered in detail. Design information is included as well as performance tradeoffs o

  20. Axial Vircator for Electronic Warfare Applications

    Directory of Open Access Journals (Sweden)

    L. Drazan


    Full Text Available This paper deals with a high power microwave generator with virtual cathode – vircator in axial release for electronic warfare applications. The classification of directed energy weapons microwave (DEWM is introduced together with basic block diagrams of a particular class of DEWM. In the paper, methods for designing vircator pulsed power supply, axial vircator structure, measurement methods and experimental results are presented. The vircator in electromagnetic ammunition is powered by magneto-cumulative generator and in weapons for defense of objects (WDO, it is powered by Marx generator. The possible applications of a vircator in the DEWM area are discussed.

  1. Droplet Reaction and Evaporation of Agents Model (DREAM). Glass model results; Sand model plans

    NARCIS (Netherlands)

    Hin, A.R.T.


    The Agent Fate Program is generating an extensive set of quality agent fate data which is being used to develop highly accurate secondary evaporation predictive models. Models are being developed that cover a wide range of traditional chemical warfare agents deposited onto surfaces routinely found o

  2. Development of a Model for Nerve Agent Inhalation in Conscious Rats (United States)


    Toxicol Mech Meth 14:183–94. Bajgar J. (2004). Organophosphates /nerve agent poisoning : mechanism of action, diagnosis, prophylaxis, and treatment. Adv...See reprint. 15. SUBJECT TERMS Chemical warfare, cholinesterases, inhalation exposure, nerve agents, organophosphates , vapor 16. SECURITY...exposure system for assessing respiratory toxicity of vaporized chemical agents in untreated, non-anesthetized rats. The organophosphate diisopropyl

  3. Lymphohematopoietic Cancers Induced by Chemicals and Other Agents: Overview and Implications for Risk Assessment (External Review Draft) (United States)

    This draft report provides an overview of the types of mechanisms underlying the lymphohematopoietic cancers induced by chemical agents and radiation in humans, with a primary emphasis on leukemia and leukemia-inducing agents. It focuses on how mechanistic information on human l...

  4. Prevalence of Asthma in Children of Chemical Warfare Victims (United States)

    Mirsadraee, Majid; Mozaffari, Abolfazl; Attaran, Davood


    Objective Exposure of DNA to sulfur mustard gas may increase the inheritance of asthma in chemical warfare victims' (CWV) offspring. The objective of this study was to determine the prevalence of asthma in children of CWV and compare it to asthmatic children in the general population. Methods Four hundred and nine children from 130 CWV fathers and 440 children from 145 asthmatic parents from two cities in Iran participated in this study. The prevalence of asthma was determined by standard questionnaire released for epidemiological survey of asthma in children and compared between two groups. Findings The prevalence of asthma in the CWV group was 15%; this was not significantly different from the control group (12.5%). The children of the CWV group reported a significantly greater incidence of wheezing (1.2±3.1 attacks) per year, but the control group reported more severe attacks leading to speech difficulties (3%) and coughing (7%). Regression analysis showed that with increasing family size in the control group, the number of subjects suffering from asthmatic symptoms decreases significantly (r=0.86, P=0.001). Conclusion Chemical agents may increase the prevalence of asthma in the offspring of CWV. PMID:23056804

  5. Extravascular injection of sclerotic agents does not affect vessels in the rat: experimental implications for percutaneous sclerotherapy of arteriovenous malformations. (United States)

    Sato, D; Kurita, M; Ozaki, M; Kaji, N; Takushima, A; Harii, K


    Sclerotherapy is useful for the treatment of arteriovenous vascular malformations. However, intravascular administration of sclerotic agents into small arteriovenous niduses is often difficult. Extravascular administration of sclerotic agents causes reduction of vascular flow on Doppler echo during clinical sclerotherapy. Therefore, we aimed to investigate whether the extravascular injection of sclerotic agents affects tiny vessels. Animal study. The effect of extravascular injection of sclerotic agents on vessels was investigated using rat femoral and superficial inferior epigastric vessels. After surgical exposure of vessels, absolute ethanol, 5% ethanolamine oleate and 3% polidocanol were injected into perivascular surrounding tissues, and their effect on vessels was evaluated after 14 days using histology and coloured silicone rubber injection. The integrity of the vascular lumen, endothelial cells and vascular patency were not affected by injection of sclerotic agents. Attenuation of vascular flow of an arteriovenous shunt after extravascular injection of sclerotic agents is transient and/or trivial and does not cause disruption of vessels. Therefore, sclerotic agents should be delivered to obtain sufficient destruction of arteriovenous malformation lesions and blood flow. Copyright © 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

  6. Environmental implications of rural policies in China: a multi-agent model at the level of agricultural households

    NARCIS (Netherlands)

    Yang, S.; Qu, Hong Juan; Luan, S.; Kroeze, C.


    We analyzed the socioeconomic and environmental changes in rural China from the perspective of agricultural households and developed a multi-agent agricultural household model for rural environmental management (MAREM). The MAREM model consists of four submodules: the agricultural household

  7. Evolutionary perspectives on collective decision making: Studying the implications of diversity and social network structure with agent-based simulations


    Sayama, Hiroki; Dionne, Shelley D.; Yammarino, Francis J.


    Collective, especially group-based, managerial decision making is crucial in organizations. Using an evolutionary theory approach to collective decision making, agent-based simulations were conducted to investigate how collective decision making would be affected by the agents' diversity in problem understanding and/or behavior in discussion, as well as by their social network structure. Simulation results indicated that groups with consistent problem understanding tended to produce higher ut...

  8. Chemical and biological warfare: Biochemistry, therapy, and treatment. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)



    The bibliography contains citations concerning biochemistry, therapy, and treatment of the effects of military chemical and biological warfare agents. References include surveys and studies of immunizing agents and drugs, the efficacy of these drugs, and the effect of the drugs on the patient. Also included are biochemical studies, assay techniques, and antidote development, some of which is supported by animal studies. Citations concerning detection and warning, defoliants, protection, biology and toxicology, and general studies are covered in separate bibliographies.(Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  9. Chemical and biological warfare: Biochemistry, therapy, and treatment. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)



    The bibliography contains citations concerning biochemistry, therapy, and treatment of the effects of military chemical and biological warfare agents. References include surveys and studies of immunizing agents and drugs, the efficacy of these drugs, and the effect of the drugs on the patient. Also included are biochemical studies, assay techniques, and antidote development, some of which is supported by animal studies. Citations concerning detection and warning, defoliants, protection, biology and toxicology, and general studies are covered in separate bibliographies.(Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  10. The implication of the ZLE Euro-mediterranean and of the partnership for the energy sector agents strategy; Les implications de la ZLE Euro-Mediterraneenne et du partenariat pour la strategie des agents du secteur energetique

    Energy Technology Data Exchange (ETDEWEB)

    Chatelus, M


    The place of the energy sector in the north-south economic relations in Mediterranean and its part in a ZLE and a partnership, zone of free exchange, justify a specific analysis. These ZLE and partnership present a non direct but important influence on the agents of the energy sector in the case of the process decided in Barcelona. In this framework, the author examines successively, a situation of the PSEM dominated by a capacity of hydrocarbons exportation and a very fast increase of the energy demand, strategy of agents weakly dependent of a ZLE, behavior influenced and results affected by the implementing of the partnership. (A.L.B.)

  11. Helicopters in Irregular Warfare: Algeria, Vietnam, and Afghanistan (United States)


    the political group associated with the Algerian nationalist independence movement GALAT Groupement d’ Aviation Légère de l’Armée de Terre ...unique from most conflicts because the expeditionary forces’ parent country rarely perceives an existential threat.19 The lack of perceived threat...dominance rarely guarantees success in irregular warfare.22 Instead, success in irregular warfare requires synergy between government and military efforts

  12. Littoral Combat Ship Open Ocean Anti-Submarine Warfare (United States)


    COVERED Capstone 4. TITLE AND SUBTITLE LITTORAL COMBAT SHIP OPEN OCEAN ANTI-SUBMARINE WARFARE 5. FUNDING NUMBERS 6. AUTHOR(S) 311-124O/Team LCS...Life cycle cost LCCE Life cycle cost estimate LCS Littoral combat ship LHA Landing ship, helicopter assault LHD Landing ship, unlimited LITTORAL COMBAT SHIP OPEN OCEAN ANTI- SUBMARINE WARFARE by Team LCS 311-124O June 2014 Capstone Advisors: John Green Dan

  13. Fourth Generation Warfare and Its Impact on the Army (United States)


    In 1989, the authors of an article entitled, "The Changing Face of War: Into the Fourth Generation ," offered a glimpse of the future rooted in the...decline of the West in a world rife with cultural conflicts and the powerful influences of a form of cultural Marxism known as political correctness...were combining in America to create conditions for a new generation of warfare. Their vision included a form of warfare that bypassed the military

  14. The Chinese People’s Liberation Army and Information Warfare (United States)


    information confrontation operations across the elec- tromagnetic spectrum. In doing so, as Dr. Wortzel’s monograph explains, the PLA used innovative means...and in- formation confrontation operations across the electro- magnetic spectrum. As this monograph explains, the PLA used innovative means to...information warfare concepts as a barometer of how the PLA approached the concept, by 2007 the threads of integrated network electronic warfare

  15. Depth vs. breadth: talent management for special warfare


    Krebs, William K.


    Approved for public release; distribution is unlimited This thesis presents recommendations for improving officer talent management for Special Warfare units. Success in this complex human domain demands that key planners and commanders of a Special Warfare campaign operate with a long-term perspective, a depth of expertise, and a strong network of relationships. However, on any given day in a U.S. Army Special Forces Group, the preponderance of field grade officers are in their first year...

  16. Naval Special Warfare Injury Prevention and Human Performance Initiative (United States)


    3. DATES COVERED (From - To) 01 JUL 10-30 JUN 12 4. TITLE AND SUBTITLE Naval Special Warfare Group 4 Injury Prevention and Human Performance...from suboptimal biomechanical, musculoskeletal, and physiological characteristics and is further compounded with poor or inadequate nutrition . The...Prescribed by ANSI Std. Z39.18 OFFICE OF NAVAL RESEARCH FINAL TECHNICAL REPORT Naval Special Warfare Injury Prevention and Human Performance

  17. Operational Ethics: Just War and Implications for Contemporary American Warfare (United States)


    unnecessary violence and excess is to be avoided.7 Later, St. Thomas Aquinas further articulated St. Augustine’s theory by proffering three necessary...of modern just war traditions. In this period several writers sought to synthesize and define St. Thomas ’ teachings on just war theory. Among them...the extent that the benefit achieved through war outweighs the harm that war causes. In addition to St. Thomas ’ three conditions Vitoria and Suarez

  18. Psychokinesis and Its Possible Implication to Warfare Strategy (United States)


    PK subject influencing objects and personnel in the friendly command’s own area. The recent initiation of experiments by William Braud and Marilyn ...Stanford, "Experimental Psychokinesis," p. 362. 22. Ibid. 23. Ibid., pp. 363-364. 24. Marilyn J. Schlitz and Gary L. Heseltine, "The 1984...Fort Monroe , Virginia: n.p., 1979). 51. Ibid. 52. McRae, Mind Wars. 53. Ibid. 39 1t U 4.-, 54. Robert G. Jahn and Brenda J. Dunne, "On the Quantum

  19. Characterizing and Exploring the Implications of Maritime Irregular Warfare (United States)


    gunfire support Sri Lanka vs. Sea Tigers Solomon Islands—regional Assistance Mission to Solomon Islands Israel vs. hezbollah OEF hoA tomahawk missile...phases I and II) Iraq—OIF (phases I and II) Vietnam—Operation Sealords persian Gulf—Operation Earnest Will OEF-P Israel vs. hezbollah Mumbai— the time of the operation’s inception in 2001–2002, then- President Gloria Macapagal- Arroyo “insisted the U.S. military role should be advisory

  20. Philippine Counterinsurgency Success: Implications for the Human Domain of Warfare (United States)


    And if it is indeed new and distinct from the land domain, inanimate and geographic, we in our Nation’s Army should be preparing ourselves to...different ethnic, cultural, and religious backgrounds. The post-World War II Philippine government has been no stranger to internal conflict...environments. We must identify how we get ourselves to where we need to be in order to best influence outcomes, to include better applying the tools we

  1. Status of Job Motivation and Job Performance of Field Level Extension Agents in Ogun State: Implications for Agricultural Development (United States)

    Fabusoro, E.; Awotunde, J. A.; Sodiya, C. I.; Alarima, C. I.


    The field level extension agents (FLEAs) are the lifeline of the agricultural extension system in Nigeria. Their motivation and job performance are therefore important to achieving faster agricultural development in Nigeria. The study identified the factors motivating the FLEAs working with Ogun State Agricultural development programme (OGADEP)…

  2. Anthropomorphism--Matters or Not? On Agent Modality and Its Implications for Teaching English Idioms and Design Decisions (United States)

    Ahmadi, Alireza; Sahragard, Rahman; Babaie Shalmani, Hamed


    The present study aimed to examine whether agent-based instruction would privilege English as a Foreign Language (EFL) learners any better than mainstream approaches (e.g. analogical reasoning, guessing from context, image formation, semantic analysis, etc.) when it comes to the teaching of English idioms. It also sought to explore whether…

  3. Evolutionary perspectives on collective decision making: Studying the implications of diversity and social network structure with agent-based simulations

    CERN Document Server

    Sayama, Hiroki; Yammarino, Francis J


    Collective, especially group-based, managerial decision making is crucial in organizations. Using an evolutionary theory approach to collective decision making, agent-based simulations were conducted to investigate how collective decision making would be affected by the agents' diversity in problem understanding and/or behavior in discussion, as well as by their social network structure. Simulation results indicated that groups with consistent problem understanding tended to produce higher utility values of ideas and displayed better decision convergence, but only if there was no group-level bias in collective problem understanding. Simulation results also indicated the importance of balance between selection-oriented (i.e., exploitative) and variation-oriented (i.e., explorative) behaviors in discussion to achieve quality final decisions. Expanding the group size and introducing non-trivial social network structure generally improved the quality of ideas at the cost of decision convergence. Simulations with ...

  4. The World War Two Allied Economic Warfare: The Case of Turkish Chrome Sales


    ÖNSOY, Murat


    Economic character of "modern warfare" is too important to be underestimated. In the Economic Warfare belligerents attempt to reduce the war capacity of the enemy through various methods. In World War II crushing down the German war production and economy was the main target of the British Ministry of Economic Warfare. For Germany, one of the many ways of overcoming the British Economic Warfare was to trade with the neutral countries that had land connection to the Third Reich. Turkey was one...

  5. Electronic Warfare Closed Loop Laboratory (EWCLL) Antenna Motor Software and Hardware Development (United States)


    ARL-TN-0779 ● SEP 2016 US Army Research Laboratory Electronic Warfare Closed Loop Laboratory (EWCLL) Antenna Motor Software and...Electronic Warfare Closed Loop Laboratory (EWCLL) Antenna Motor Software and Hardware Development by Neal Tesny Sensors and Electron Devices Directorate...TITLE AND SUBTITLE Electronic Warfare Closed Loop Laboratory (EWCLL) Antenna Motor Software and Hardware Development 5a. CONTRACT NUMBER 5b

  6. Capillary gas chromatographic analysis of nerve agents using large volume injections

    NARCIS (Netherlands)

    Degenhardt, C.E.A.M.; Kientz, C.E.


    The use of large volume injections has been studied for the verification of intact organophosphorus chemical warfare agents in water samples. As the use of ethyl acetate caused severe detection problems new potential solvents were evaluated. With the developed procedure, the nerve agents sarin, tabu

  7. APSTNG: neutron interrogation for detection of explosives, drugs, and nuclear and chemical warfare materials (United States)

    Rhodes, Edgar A.; Peters, Charles W.


    A recently developed neutron diagnostic probe system has the potential to satisfy a significant number of van-mobile and fixed-portal requirements for nondestructive detection, including monitoring of contraband explosives, drugs, and weapon materials, and treaty verification of sealed munitions. The probe is based on a unique associated-particle sealed-tube neutron generator (APSTNG) that interrogates the object of interest with a low-intensity beam of 14- MeV neutrons generated from the deuterium-tritium reaction and that detects the alpha-particle associated with each neutron. Gamma-ray spectra of resulting neutron reactions identify nuclides associated with all major chemicals in explosives, drugs, and chemical warfare agents, as well as many pollutants and fissile and fertile special nuclear material. Flight times determined from detection times of the gamma-rays and alpha-particles yield a separate coarse tomographic image of each identified nuclide. The APSTNG also forms the basis for a compact fast-neutron transmission imaging system that can be used along with or instead of the emission imaging system. Proof-of-concept experiments have been performed under laboratory conditions for simulated nuclear and chemical warfare munitions and for explosives and drugs. The small and relatively inexpensive APSTNG exhibits high reliability and can be quickly replaced. Surveillance systems based on APSTNG technology can avoid the large physical size, high capital and operating expenses, and reliability problems associated with complex accelerators.

  8. An Empirical Examination of the Warfare Metaphor with Respect to Pre-Service Elementary Teachers (United States)

    Cobern, William W.; Loving, Cathleen C.; Davis, Edward B.; Terpstra, Jeff


    Since its origination in the late nineteenth century, the warfare metaphor has been used to characterize the relationship between science and religion, especially orthodox Christianity. Though thoroughly discredited by historians of science, the ideological descendants of Thomas Huxley, who spoke of science in quasi-religious terms, have kept the warfare metaphor alive. On the other hand, there are substantial numbers of Christians who at least appear to oppose science given their high-profile opposition to the general theory of evolution. The research reported in this paper asked, "Does anti-science sentiment increase with increasing orthodox Christian belief?" Two validated, published instruments were used: The Thinking about Science Survey Instrument and the Christian Fundamentalist Belief Scale. The subjects for the study were 545 preservice elementary teachers. The analysis did not show that anti-science sentiment increases with increasing Christian belief. Subjects with strong Christian beliefs were found to be just as supportive of science, if not more so, than subjects with no Christian beliefs. The study concludes with a caution against projecting attitudes toward science "on the whole" based on attitudes specifically toward evolution when working with preservice elementary teachers. Such a projection could well be counterproductive. The study has implications for other modern countries having highly religious populations such as Turkey.

  9. Economic Implications of Historically Evolved Self-Efficacy: Agent-Based Modeling and Empirical Evidence from Rural Ghana


    Wuepper, David; Drosten, Barbara


    We argue that self-efficacy is important for economic performance. Self-efficacy is at the psychological core of agency and entrepreneurship. It enables people to learn, and change and act to better their livelihood. In an agent-based model we show how different levels of individual self-efficacy can evolve as a reaction to environmental demands and rewards to human intervention. The basic idea is that people learn how to best survive in their specific environment and teach this knowledge to ...

  10. Numerical simulation of RCS for carrier electronic warfare airplanes

    Directory of Open Access Journals (Sweden)

    Yue Kuizhi


    Full Text Available This paper studies the radar cross section (RCS of carrier electronic warfare airplanes. Under the typical naval operations section, the mathematical model of the radar wave’s pitch angle incidence range analysis is established. Based on the CATIA software, considering dynamic deflections of duck wing leading edge flaps, flaperons, horizontal tail, and rudder, as well as aircraft with air-to-air missile, anti-radiation missile, electronic jamming pod, and other weapons, the 3D models of carrier electronic warfare airplanes Model A and Model B with weapons were established. Based on the physical optics method and the equivalent electromagnetic flow method, by the use of the RCSAnsys software, the characteristics of carrier electronic warfare airplanes’ RCS under steady and dynamic flights were simulated under the UHF, X, and S radar bands. This paper researches the detection probability of aircraft by radars under the condition of electronic warfare, and completes the mathematical statistical analysis of the simulation results. The results show that: The Model A of carrier electronic warfare airplane is better than Model B on stealth performance and on discover probability by radar detection effectively.

  11. Influence of dispersive agent on nanomaterial agglomeration and implications for biological effects in vivo or in vitro. (United States)

    Sauer, Ursula G; Aumann, Alexandra; Ma-Hock, Lan; Landsiedel, Robert; Wohlleben, Wendel


    Comparing the dispersing properties of the porcine lung surfactant Curosurf(®) to bovine serum albumin (BSA), the present study investigated how a more close simulation of the in vivo situation influences nanomaterial dispersion and hence the proportion of the administered dose that will reach the in vitro test system, i.e. the ‘effective dose’. Dispersions of 16 OECD reference nanomaterials (ZnO, Ag, TiO(2), CeO(2), SiO(2), and multi-walled carbon nanotubes (MWCNTs) were assessed. Overall, the NMs were better dispersed in the BSA-supplemented medium. BSA-addition combined with ultrasonication proved most effective in deagglomerating MWCNTs, but also reduced agglomeration for most metal oxidenanomaterials as compared to the Curosurf(®) dispersions. However, all materials were at least partially agglomerated in either dispersing agent. For the different nanomaterials, the calculated effective dosage upon 12- or 24-h test substance incubation differed considerably (and to different extents) depending on the applied dispersing agent. When testing nanomaterial effects in vitro, selection of the type of cell culture medium and its additives should take into account what the system is intended to mimic. Study protocols should address whether they aim at best-possible dispersion of the nanomaterials or at simulating more realistically in vivo tissue uptake and distribution.

  12. Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning. (United States)

    Carvalho, Cristina M L; Lu, Jun; Zhang, Xu; Arnér, Elias S J; Holmgren, Arne


    Mercury toxicity is a highly interesting topic in biomedicine due to the severe endpoints and treatment limitations. Selenite serves as an antagonist of mercury toxicity, but the molecular mechanism of detoxification is not clear. Inhibition of the selenoenzyme thioredoxin reductase (TrxR) is a suggested mechanism of toxicity. Here, we demonstrated enhanced inhibition of activity by inorganic and organic mercury compounds in NADPH-reduced TrxR, consistent with binding of mercury also to the active site selenolthiol. On treatment with 5 μM selenite and NADPH, TrxR inactivated by HgCl(2) displayed almost full recovery of activity. Structural analysis indicated that mercury was complexed with TrxR, but enzyme-generated selenide removed mercury as mercury selenide, regenerating the active site selenocysteine and cysteine residues required for activity. The antagonistic effects on TrxR inhibition were extended to endogenous antioxidants, such as GSH, and clinically used exogenous chelating agents BAL, DMPS, DMSA, and α-lipoic acid. Consistent with the in vitro results, recovery of TrxR activity and cell viability by selenite was observed in HgCl(2)-treated HEK 293 cells. These results stress the role of TrxR as a target of mercurials and provide the mechanism of selenite as a detoxification agent for mercury poisoning.

  13. Biphasic toxicodynamic features of some antimicrobial agents on microbial growth: a dynamic mathematical model and its implications on hormesis

    Directory of Open Access Journals (Sweden)

    Murado Miguel A


    Full Text Available Abstract Background In the present work, we describe a group of anomalous dose-response (DR profiles and develop a dynamic model that is able to explain them. Responses were obtained from conventional assays of three antimicrobial agents (nisin, pediocin and phenol against two microorganisms (Carnobacterium piscicola and Leuconostoc mesenteroides. Results Some of these anomalous profiles show biphasic trends which are usually attributed to hormetic responses. But they can also be explained as the result of the time-course of the response from a microbial population with a bimodal distribution of sensitivity to an effector, and there is evidence suggesting this last origin. In light of interest in the hormetic phenomenology and the possibility of confusing it with other phenomena, especially in the bioassay of complex materials we try to define some criteria which allow us to distinguish between sensu stricto hormesis and biphasic responses due to other causes. Finally, we discuss some problems concerning the metric of the dose in connection with the exposure time, and we make a cautionary suggestion about the use of bacteriocins as antimicrobial agents. Conclusions The mathematical model proposed, which combines the basis of DR theory with microbial growth kinetics, can generate and explain all types of anomalous experimental profiles. These profiles could also be described in a simpler way by means of bisigmoidal equations. Such equations could be successfully used in a microbiology and toxicology context to discriminate between hormesis and other biphasic phenomena.

  14. Food intake and reward mechanisms in patients with schizophrenia: implications for metabolic disturbances and treatment with second-generation antipsychotic agents. (United States)

    Elman, Igor; Borsook, David; Lukas, Scott E


    Obesity is highly prevalent among patients with schizophrenia and is associated with detrimental health consequences. Although excessive consumption of fast food and pharmacotherapy with such second-generation antipsychotic agents (SGAs) as clozapine and olanzapine has been implicated in the schizophrenia/obesity comorbidity, the pathophysiology of this link remains unclear. Here, we propose a mechanism based on brain reward function, a relevant etiologic factor in both schizophrenia and overeating. A comprehensive literature search on neurobiology of schizophrenia and of eating behavior was performed. The collected articles were critically reviewed and relevant data were extracted and summarized within four key areas: (1) energy homeostasis, (2) food reward and hedonics, (3) reward function in schizophrenia, and (4) metabolic effects of the SGAs. A mesolimbic hyperdopaminergic state may render motivational/incentive reward system insensitive to low salience/palatability food. This, together with poor cognitive control from hypofunctional prefrontal cortex and enhanced hedonic impact of food, owing to exaggerated opioidergic drive (clinically manifested as pain insensitivity), may underlie unhealthy eating habits in patients with schizophrenia. Treatment with SGAs purportedly improves dopamine-mediated reward aspects, but at the cost of increased appetite and worsened or at least not improved opiodergic capacity. These effects can further deteriorate eating patterns. Pathophysiological and therapeutic implications of these insights need further validation via prospective clinical trials and neuroimaging studies.

  15. Concepto y fuentes para el estudio de la Information Warfare


    Tramullas Saz, Jesús


    En este trabajo se aborda el concepto de Información Warfare, así como las principales definiciones que se han propuesto para el mismo. Se establecen los diferentes tipos de acciones que se inscriben en este ámbito, y se delinean algunas implicaciones para el especialista en información. Como punto de partida para su estudio, se incluyen una selección de fuentes de información sobre el tema objeto de estudio. ABSTRACT: This paper broaches the concept of Information Warfare, as ...

  16. Possible Long Term Effects of Chemical Warfare Using Visual Evoked Potentials

    Directory of Open Access Journals (Sweden)

    Abbas Riazi


    Full Text Available Some studies have already addressed the effects of occupational organic solvent exposure on the visually evoked potentials (VEPs. Visual system is an important target for Sulphur Mustard (SM toxicity. A number of Iranian victims of Sulphur Mustard (SM agent were apprehensive about the delay effect of SM on their vision and a possible delay effect of SM on their visual cortex. This investigation was performed on 34 individuals with a history of chemical exposure and a control group of 15 normal people. The Toennies electro-diagnosis device was used and its signals were saved as the latencies. The mean of N75, N140 and P100 of victims of chemical warfare (VCWs and control group indicated no significant results (P>0.05. The VCWs did not show any visual symptoms and there was no clear deficit in their VEPs.

  17. The art of antibacterial warfare: Deception through interference with quorum sensing-mediated communication. (United States)

    Rampioni, Giordano; Leoni, Livia; Williams, Paul


    Almost a century on from the discovery of penicillin, the war against bacterial infection still rages compounded by the emergence of strains resistant to virtually every clinically approved antibiotic and the dearth of new antibacterial agents entering the clinic. Consequently there is renewed interest in drugs which attenuate virulence rather than bacterial growth. Since the metaphors of warfare are often used to describe the battle between pathogen and host, we will describe in such a context, the molecular communication (quorum sensing) mechanisms used by bacteria to co-ordinate virulence at the population level. Recent progress in exploiting this information through the design of anti-virulence deception strategies that disrupt quorum sensing through signal molecule inactivation, inhibition of signal molecule biosynthesis or the blockade of signal transduction and their advantages and disadvantages are considered.

  18. The effects of prednisone and steroid-sparing agents on decay accelerating factor (CD55) expression: implications in myasthenia gravis. (United States)

    Auret, Jennifer; Abrahams, Amaal; Prince, Sharon; Heckmann, Jeannine M


    Decay accelerating factor (DAF) expression at the muscle endplate is an important defence against complement-mediated damage in myasthenia gravis. Previously we implicated the c.-198C>G DAF polymorphism with the development of treatment-resistant myasthenia-associated ophthalmoplegia by showing that the C>G DAF polymorphism prevented lipopolysaccharide-induced upregulation of lymphoblast DAF. We postulated that drugs used in myasthenia gravis may increase the susceptibility of extraocular muscles to complement-mediated damage and studied their effects on endogenous DAF using patient-derived lymphoblasts as well as mouse myotubes. We show that prednisone repressed C>G DAF expression in lymphoblasts and increased their susceptibility to cytotoxicity. Methotrexate, but not azathioprine or cyclosporine, increased DAF in C>G lymphoblasts. In mouse myotubes expressing wild-type Daf, prednisone also repressed Daf expression. Although cyclosporine, azathioprine, and methotrexate increased muscle Daf levels when used alone, upon co-treatment with prednisone only azathioprine maintained myotube Daf levels close to basal. Therefore, prednisone negatively influences DAF expression in C>G lymphoblasts and in myotubes expressing wild-type Daf. We speculate that myasthenic individuals at risk of developing the ophthalmoplegic complication, such as those with C>G DAF, may have inadequate endogenous levels of complement regulatory protein protection in their extraocular muscle in response to prednisone, increasing their susceptibility to complement-mediated damage.

  19. Chemical and Biological Warfare: Should Rapid Detection Techniques Be Researched To Dissuade Usage? A Review

    Directory of Open Access Journals (Sweden)

    Mark R. Hurst


    Full Text Available Chemistry, microbiology and genetic engineering have opened new doorways for the human race to propel itself to a better future. However, there is a darker side to Bioengineering. One element of this is the manufacture and proliferation of biological and chemical weapons. It is clearly in the interest of humankind to prevent the future use of such weapons of mass destruction. Though many agents have been proposed as potential biological and chemical weapons, the feasibility of these weapons is a matter of conjecture. The unpredictable and indiscriminate devastation caused by natural epidemics and hazardous chemicals during wartime without medical treatment should warn humans of the dangers of employing them as weapons. This study argues rapid detection techniques may dissuade future use. Many agents are far less toxic to treatment. A quick response time to most attacks will decrease the chances of serious health issues. The agent will be less effective and discourage the attacker from using the weapon. Fortunately, the Chemical and Biological Weapons Convention (CWCIBWC allows defensive work in the area of biological and chemical weapons. Consequently, the review will discuss history, delivery/dispersal systems and specific agents of the warfare. The study presents current developments in biosensors for toxic materials of defense interest. It concludes with future directions for biosensor development.

  20. Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents

    Energy Technology Data Exchange (ETDEWEB)

    Muench, Stephen P. [The Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN (United Kingdom); Prigge, Sean T. [Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 (United States); McLeod, Rima [Department of Ophthalmology and Visual Sciences, Paediatrics (Infectious Diseases) and Pathology and the Committees on Molecular Medicine, Genetics, Immunology and The College, The University of Chicago, Chicago, IL 60637 (United States); Rafferty, John B. [The Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN (United Kingdom); Kirisits, Michael J. [Department of Ophthalmology and Visual Sciences, Paediatrics (Infectious Diseases) and Pathology and the Committees on Molecular Medicine, Genetics, Immunology and The College, The University of Chicago, Chicago, IL 60637 (United States); Roberts, Craig W. [Department of Immunology, University of Strathclyde, Glasgow G4 0NR, Scotland (United Kingdom); Mui, Ernest J. [Department of Ophthalmology and Visual Sciences, Paediatrics (Infectious Diseases) and Pathology and the Committees on Molecular Medicine, Genetics, Immunology and The College, The University of Chicago, Chicago, IL 60637 (United States); Rice, David W., E-mail: [The Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN (United Kingdom)


    The crystal structures of T. gondii and P. falciparum ENR in complex with NAD{sup +} and triclosan and of T. gondii ENR in an apo form have been solved to 2.6, 2.2 and 2.8 Å, respectively. Recent studies have demonstrated that submicromolar concentrations of the biocide triclosan arrest the growth of the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii and inhibit the activity of the apicomplexan enoyl acyl carrier protein reductase (ENR). The crystal structures of T. gondii and P. falciparum ENR in complex with NAD{sup +} and triclosan and of T. gondii ENR in an apo form have been solved to 2.6, 2.2 and 2.8 Å, respectively. The structures of T. gondii ENR have revealed that, as in its bacterial and plant homologues, a loop region which flanks the active site becomes ordered upon inhibitor binding, resulting in the slow tight binding of triclosan. In addition, the T. gondii ENR–triclosan complex reveals the folding of a hydrophilic insert common to the apicomplexan family that flanks the substrate-binding domain and is disordered in all other reported apicomplexan ENR structures. Structural comparison of the apicomplexan ENR structures with their bacterial and plant counterparts has revealed that although the active sites of the parasite enzymes are broadly similar to those of their bacterial counterparts, there are a number of important differences within the drug-binding pocket that reduce the packing interactions formed with several inhibitors in the apicomplexan ENR enzymes. Together with other significant structural differences, this provides a possible explanation of the lower affinity of the parasite ENR enzyme family for aminopyridine-based inhibitors, suggesting that an effective antiparasitic agent may well be distinct from equivalent antimicrobials.

  1. Employing U.S. Information Operations Against Hybrid Warfare Threats (United States)


    activities” ( CEMA ), which is a combination of Cyber and Electronic Warfare.115 However, the relationship between cyber and EW must be carefully considered...generating effects by themselves, as well as serving as a delivery means for MISO. The focus of CEMA may be as much to support combat operations

  2. Anti-submarine warfare with continuously active sonar

    NARCIS (Netherlands)

    Vossen, R. van; Beerens, S.P.; Spek, E. van der


    Existing surveillance sonar systems for anti-submarine warfare (ASW) use a pulsed sonar deployed at a low duty cycle. Continuously active sonar (CAS) is of special interest since the technique could provide better detection performance than conventional pulsed sonar, and it will provide the operator

  3. Trends in underwater warfare : From an underwater acoustics perspective

    NARCIS (Netherlands)

    Ort, C.M.; Driessen, F.P.G.


    Technological developments concerning underwater systems for Anti Submarine Warfare (ASW) and Mine Counter Measures (MCM) are directed at optimally countering the underwater threat in the near future. Countering the existing underwater threat is already extremely difficult, but there are several tre

  4. Public Discussion of Nuclear Warfare: A Time for Hope. (United States)

    Cooper, Martha

    Anti-nuclear discourse, which peaked in 1981-82, signaled an emergence of public discourse on the nuclear warfare issue. During the development of the original atomic bomb, public discussion of the issue was severely restricted, but immediately after the bombing of Hiroshima and Nagasaki, discourse on the subject increased. During the Cold War…

  5. Just War and Postmodern Warfare: A German Case Study (United States)


    Germany’s cognitive dissonance about the importance of military force and counter-insurgency operations in Afghanistan is an uphill battle they are still...1 Summary of Walzer’s Contemporary Just War Theory : ……............................................................2 Summary of...Postmodern Warfare Theory : .......................................................................................5 German Foreign Policy and Military

  6. Ethical Considerations of Computer Network Attack in Information Warfare (United States)


    attack/destruction, and special information operations (SIO). CNA and the other methods of offensive IO represent the incorporation of information...psychological operations, electronic warfare, physical attack and/or destruction, and special information operations, and could include computer computer networks to record information sent over them. 41 special information operations. Information operations that by their sensitive nature

  7. Management information systems for electronic warfare command and decision support

    CSIR Research Space (South Africa)

    Van Niekerk, B


    Full Text Available information to allow them to manage their own spectrum, to identify threats, and to deny adversaries’ use of the spectrum. In this paper, the concepts of integrated electronic warfare and spectrum battle management are introduced, and the relevant information...

  8. Improving Professional Development for USAF Electronic Warfare Officers (United States)


    NOTE AIR WAR COLLEGE AIR UNIVERSITY IMPROVING PROFESSIONAL DEVELOPMENT FOR USAF ELECTRONIC WARFARE OFFICERS by Gregory M. Patschke, Col...and planning. Professional development comprises both continuing education and career development. In the US Air Force, the acquisition, space...and cyberspace communities have professional development programs already in place. For the continuing education half of professional development , the

  9. Bream (Abramis brama (L.)) as zoogeomorphic agents and ecosystem engineers: Implications for fine sediment transport in lowland rivers (United States)

    Smith, James; Rice, Stephen; Hodgkins, Richard


    Despite increasing recognition that animals play important roles in geomorphological systems (zoogeomorphology), with important ecological implications for the animals and their ecosystems (ecosystem engineering), sediment transport continues to be regarded as an abiotic process. This research challenges that orthodoxy by investigating the biotic processes associated with bioturbation in rivers caused by feeding bream (Abramis brama (L.)) and quantifying their impact on fine sediment suspension and sediment yield. Experiments in lakes have demonstrated that bream negatively influence ecosystem dynamics through bottom up mechanisms as a result of physical bioturbation caused by benthivorous feeding. Although this level of bioturbation, and thus sediment entrainment, can alter the fundamental biogeochemical cycles and food web dynamics in lentic ecosystems, research is yet to assess this potential effect in riverine ecosystems or evaluate this bioturbation mechanism as a driver of fluvial sediment flux - even though they are common in rivers across mainland Europe. A series of ex-situ mesocosm experiments have investigated the controls of fine sediment entrainment by bream, assessing the roles of both biomass (size and number) and food density on suspended sediment concentration and turbidity. Bream create large volumes of suspended sediment during feeding (highest recorded turbidity 1172 NTU) and there are significant (p experimental parameter: number of fish, fish size and food density. Supplementary experiments have assessed bream as ecosystem engineers in the presence of the congener species, roach (Rutilus rutilus (L.)), which share the same ecological niche. In the presence of roach, the impact of bream on turbidity increased by an average of 120% (6.6 NTU to 15 NTU) and increased further at the 90th percentile by 240% (32 NTU to 110 NTU). In light of these findings, the extensive geographical distribution of bream and the observation that shoals of bream

  10. Simulating cyber warfare and cyber defenses: information value considerations (United States)

    Stytz, Martin R.; Banks, Sheila B.


    Simulating cyber warfare is critical to the preparation of decision-makers for the challenges posed by cyber attacks. Simulation is the only means we have to prepare decision-makers for the inevitable cyber attacks upon the information they will need for decision-making and to develop cyber warfare strategies and tactics. Currently, there is no theory regarding the strategies that should be used to achieve objectives in offensive or defensive cyber warfare, and cyber warfare occurs too rarely to use real-world experience to develop effective strategies. To simulate cyber warfare by affecting the information used for decision-making, we modify the information content of the rings that are compromised during in a decision-making context. The number of rings affected and value of the information that is altered (i.e., the closeness of the ring to the center) is determined by the expertise of the decision-maker and the learning outcome(s) for the simulation exercise. We determine which information rings are compromised using the probability that the simulated cyber defenses that protect each ring can be compromised. These probabilities are based upon prior cyber attack activity in the simulation exercise as well as similar real-world cyber attacks. To determine which information in a compromised "ring" to alter, the simulation environment maintains a record of the cyber attacks that have succeeded in the simulation environment as well as the decision-making context. These two pieces of information are used to compute an estimate of the likelihood that the cyber attack can alter, destroy, or falsify each piece of information in a compromised ring. The unpredictability of information alteration in our approach adds greater realism to the cyber event. This paper suggests a new technique that can be used for cyber warfare simulation, the ring approach for modeling context-dependent information value, and our means for considering information value when assigning cyber

  11. FOA Information from the Research Institute of Swedish National Defence on Electronic Warfare (FOA Orientar om Electronic Warfare), (United States)


    modified. If it is appears as if the psychological It is hardly likely. however. known that the opponent has a warfare element involved there- that the most...34 . -roadeatla - ".-Rhdar Raa -* * - cldignsl Toi~loieey aft u comunication , ntavigation -ctionl Examples of applications Radar bands FroquaP" UMI 0.1

  12. Effects of CW (chemical warfare)-related chemicals on social behavior and performance. Annual report, 30 September 1984-29 September 1985

    Energy Technology Data Exchange (ETDEWEB)

    Bunnell, B.N.; Iturrian, W.B.


    This report summarizes work accomplished in the second year of a three-year project aimed at developing a battery of tests of social behavior and performance that wil be sensitive to the effects of chemical warfare-related chemicals considered for use as antidotes or prophylactics against chemical-warfare agents. Procedures for assessing social behavior in nonhuman primates are described and compared. Performance scores on three operant schedules, a test of complex problem solving, and behavior in a novel environment are presented and correlations between the social and performance variables are examined. The effects of atropines on several of the social and performance measures are reported as are data from plasma hormone assays for cortisol and prolactin.

  13. Evolution of Unmanned Aerial Warfare: A Historical Look at Remote Airpower - A Case Study in Innovation (United States)


    EVOLUTION OF UNMANNED AERIAL WARFARE: A HISTORICAL LOOK AT REMOTE AIRPOWER—A CASE STUDY IN INNOVATION A thesis presented to...JUN 2016 4. TITLE AND SUBTITLE Evolution of Unmanned Aerial Warfare: A Historical Look at Remote Airpower—A Case Study in Innovation 5a...Warfare: A Historical Look at Remote Airpower—A Case Study in Innovation Approved by: , Thesis Committee Chair John T. Kuehn, Ph.D

  14. Electronic Warfare M-on-N Digital Simulation Logging Requirements and HDF5: A Preliminary Analysis (United States)


    E. Jarvis Electronic Warfare M-on- N Digital Simulation Logging Requirements and HDF5: A Preliminary Analysis Advanced Techniques Branch Tactical...12-04-2017 NRL Memorandum Report Electronic Warfare M-on- N Digital Simulation Logging Requirements and HDF5: A Preliminary Analysis Donald E...ELECTRONIC WARFARE M-ON- N DIGITAL SIMULATION LOGGING REQUIREMENTS AND HDF5: A PRELIMINARY ANALYSIS 1. INTRODUCTION HDF5 technology [Folk] has been

  15. Bioterrorism and Biological Warfare, from Past to the Present: A classic review

    Directory of Open Access Journals (Sweden)

    Majid Zare Bidaki


    Full Text Available Bioterrorism is defined as any terrorist action of intentional release or dissemination of highly pathogenic biological agents, including a variety of microorganisms or biological toxins. With the growing threat of terrorism, is necessary that the potential danger of various microorganisms – as a powerful tool of aggression and threat- to be taken seriously. This review tries to explain the concept of biological weapons and their historical development process with an emphasis on efforts to control the proliferation of these types of weapons over the last century. Potential impact of infectious diseases on people and armed forces was known from since 600 BC. Using the victims of the plague as a weapon in medieval warfare and spread of smallpox as a weapon during the war against the Indians when initially America was discovered, the development of biological weapons during the World War I, World War II and the Cold War, and even since the beginning of the third millennium, all show the strategic importance of pathogenic microorganisms as a deterrent power for the superiority of some governments and cults. Historical attempts to use infectious diseases as biological weapons reveal that the distinction between a natural outbreak of an infectious disease and that of a deliberate biological attack is very difficult. Abusing this characteristic of infectious diseases has made it possible for the purposes of superiority. International agreements to control the development of biological weapons, such as “the 1925 Geneva Protocol” and “the Convention on the Prohibition of the Development, Production and Stockpiling of Biological and Toxic Weapons” have not been able to control the development and using of biological warfare.  The current paper is a classic review (Overview article aiming at increasing the knowledge and awareness of people especially of health authorities and government officials.

  16. Signal crayfish as zoogeomorphic agents: diel patterns of fine sediment suspension in a crayfish-affected river and the implications for fine sediment fluxes and dynamics (United States)

    Rice, Stephen; Johnson, Matthew; Reeds, Jake; Longstaff, Holly; Extence, Chris


    agents that accelerate fine sediment recruitment and promote the mobility and turnover of fine sediments once they are in the channel network, with potential implications for the management of fine sediment pressures in European rivers. Moreover, crayfish are probably one of thousands of species that may, cumulatively, have a substantial impact on river sediment dynamics. The tantalizing possibility that these animals are significant actors in catchment-scale sediment dynamics challenges the conventional view that sediment systems are abiotic and warrants greater scientific attention.

  17. Stuxnet and Cyber-Warfare (1/2)

    CERN Document Server

    CERN. Geneva


    The first part of the lecture is devoted to the description of the Stuxnet worm, the first cyber-weapon whose existence has been made public, discovered in 2010 and targeting a specific industrial control system; the worm is responsible for the damaging of many centrifuges at an uranium enrichment facility, with the goal of sabotaging Iran's nuclear program. In the second part, the main features of cyber-warfare in conflict and pre-conflict activities will be discussed and compared to the conventional warfare domains, with also a general view at the international political debate on this topic. Check the web site, an organisation that seeks a world free of nuclear weapons and other weapons of mass destruction.   NB! All Academic Training lectures are recorded and are publicly available. There is no live webcast.

  18. Stuxnet and Cyber-Warfare (2/2)

    CERN Document Server

    CERN. Geneva


    The first part of the lecture is devoted to the description of the Stuxnet worm, the first cyber-weapon whose existence has been made public, discovered in 2010 and targeting a specific industrial control system; the worm is responsible for the damaging of many centrifuges at an uranium enrichment facility, with the goal of sabotaging Iran's nuclear program. In the second part, the main features of cyber-warfare in conflict and pre-conflict activities will be discussed and compared to the conventional warfare domains, with also a general view at the international political debate on this topic.   Check the web site, an organisation that seeks a world free of nuclear weapons and other weapons of mass destruction. The lecturer invites comments via email to NB! All Academic Training lectures are recorded and are publicly available. There is no live webcast.

  19. Antineoplastic agents and thrombotic microangiopathy. (United States)

    Garcia, Gwenalyn; Atallah, Jean Paul


    Thrombotic microangiopathy is an uncommon but reported adverse effect of a variety of antineoplastic drugs, including chemotherapy agents such as mitomycin C and gemcitabine, and newer targeted agents such as the vascular endothelial growth factor inhibitors. We present a review of thrombotic microangiopathy associated with antineoplastic agents and its implications in current cancer therapy.

  20. A short history of biological warfare. (United States)

    Metcalfe, Neil


    Biological weapons have been used in war from the start of recorded history. This article reviews the history of the subject, including the outbreak of the Black Death and the use of smallpox against American Indians. The new science of microbiology was misused from soon after its start and, despite the 1925 Geneva Protocol, the Japanese experimented extensively on prisoners in China. The Allies carried out extensive research during the Second World War, notably the United Kingdom into anthrax on Gruinard Island and the United States into a variety of agents. Despite the 1972 Biological Weapons Convention (BWC), a major programme continued in the former Soviet Union (leading to an accidental outbreak of anthrax). Most recently Iraq was revealed as having an extensive programme, with weaponization of large amounts of various agents, and several terrorists groups have attempted to use biological agents as weapons. Modern developments in biotechnology could lead to even more serious developments, and effective preventive measures, including strengthening of the BWC, are imperative.

  1. USMC Electronic Warfare 2025: Trading Expertise for Advanced Technology (United States)


    airborne electronic warlare during the transition period away from legacy equipment. EA-6B pilots and Electroilic Countermeasures Officers ( ECMOs ...Electronic Warfare (EW) capability. As an EA-6B Electronic Countenneasures Officer ( ECMO ), I anticipate that both the United States Marine Corps and all... ECMOs . An increased workload for Radio Battalion will have the same effect that the assumption of an additional function of Marine aviation will have on

  2. China's Use of Cyber Warfare: Espionage Meets Strategic Deterrence



    This article presents three reasons for states to use cyber warfare and shows that cyberspace is—and will continue to be—a decisive element in China's strategy to ascend in the international system. The three reasons are: deterrence through infiltration of critical infrastructure; military technological espionage to gain military knowledge; and industrial espionage to gain economic advantage. China has a greater interest in using cyberspace offensively than other actors, such as the United St...

  3. Wrestling the Bear: The Rise of Russian Hybrid Warfare (United States)


    integrity. Essentially, Russia - and more directly- Vladimir Putin perceive that Russia is in an ideological struggle with the US and Europe. 1 Carl Von...conducted in a hybrid manner, though all the instruments of national power. 31 Though the nearly continuous strategic leadership of Vladimir Putin , Russia ...with a sharp focus on Vladimir Putin ’s strategic leadership, highlights the evolution ofthe Russian brand of hybrid warfare (HW). The analysis also

  4. Beyond Mission Command: Maneuver Warfare for Cyber Command and Control (United States)


    elements with maneuver warfare, mission command’s decentralization of execution through the use of mission-type orders is a more centralized form... decentralized command and control organization will instill an innovative organizational culture. Innovation will be able to freely prosper in an...warfare’s decentralized command and control doctrine to maximize military cyberspace operations. Since the establishment of U.S. Cyber Command in 2009

  5. The Enemy Below: Preparing Ground Forces for Subterranean Warfare (United States)


    can endanger the lives of U.S. forces and render mechanical breaching tools inoperable. Air blowers can be used as a hasty means to ventilate a... Penguin Books, 1996). 179 Tom Mangold, The Tunnels of Cu Chi (New York, NY: Random House, 1985). 147 6. A Historical Analysis of Tunnel Warfare and... Penguin Group, 1996. 157 Lester, W. G., & Ali, A. J. “Underground Combat: Stereophonic Blasting, tunnel Rats, and the Soviet-Afghan War.” Engineer

  6. Russian and Chinese Information Warfare: Theory and Practice (United States)


    Integral neurolinguistic programming •Placing essential programs into the conscious or sub- conscious mind •Subconscious suggestions that modify human...Generators of special rays •Optical systems • Neurolinguistic programming •Computer psychotechnology •The mass media •Audiovisual effects •Special effects...Information Warfare: Theory and Practice 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e

  7. Cyberspace Warfare: A New DoD Core Mission Area (United States)


    states to take note. Cyber issues such as these should be seen in light of the ancient dictum that “a victorious army first wins and then seeks...Examples from ancient Greece, Prussia, and World War II are illustrated to present cases where innovative leaders adapted and modified their methods to...conduct warfare and integrated them into their strategic approach to achieve their desired end states. Alexander the Great conquered Persia in three

  8. Constitution aims to bring an end to health economy warfare. (United States)

    Harding, Mary-Louise; Martin, Daniel


    A rough new constitution is being drawn up for the NHS in a bid to prevent health economies sliding into bitter 'Bradford-style' warfare in the era of foundations trusts and payment by results. The rules of engagement are part of a package of measures designed to rescue some of the government's flagship reforms amid warnings from audit chiefs on the impact of PbR.

  9. Organic Chemical Attribution Signatures for the Sourcing of a Mustard Agent and Its Starting Materials

    Energy Technology Data Exchange (ETDEWEB)

    Fraga, Carlos G.; Bronk, Krys; Dockendorff, Brian P.; Heredia-Langner, Alejandro


    Chemical attribution signatures (CAS) are being investigated for the sourcing of chemical warfare (CW) agents and their starting materials that may be implicated in chemical attacks or CW proliferation. The work reported here demonstrates for the first time trace impurities produced during the synthesis of tris(2-chloroethyl)amine (HN3) that point to specific reagent stocks used in the synthesis of this CW agent. Thirty batches of HN3 were synthesized using different combinations of commercial stocks of triethanolamine (TEA), thionyl chloride, chloroform, and acetone. The HN3 batches and reagent stocks were then analyzed for impurities by gas chromatography/mass spectrometry. Reaction-produced impurities indicative of specific TEA and chloroform stocks were exclusively discovered in HN3 batches made with those reagent stocks. In addition, some reagent impurities were found in the HN3 batches that were presumably not altered during synthesis and believed to be indicative of reagent type regardless of stock. Supervised classification using partial least squares discriminant analysis (PLSDA) on the impurity profiles of chloroform samples from seven stocks resulted in an average classification error by cross-validation of 2.4%. A classification error of zero was obtained using the seven-stock PLSDA model on a validation set of samples from an arbitrarily selected chloroform stock. In a separate analysis, all samples from two of seven chloroform stocks that were purposely not modeled had their samples matched to a chloroform stock rather than assigned a “no class” classification.

  10. Exposure to a First World War blistering agent. (United States)

    Le, H Q; Knudsen, S J


    Sulfur mustards act as vesicants and alkylating agents. They have been used as chemical warfare since 1917 during the first world war. This brief report illustrates the progression of injury on a primary exposed patient to a first world war blistering agent. This case documents the rapid timeline and progression of symptoms. It emphasises the importance of appropriate personal protective equipment and immediate medical response plan with rapid decontamination and proper action from military and civilian medical treatment facilities. This case reports the first US active duty military exposure to a blistering agent in the age of global terrorism.

  11. Echo chamber and trench warfare dynamics in online debates. (United States)

    Karlsen, Rune; Steen-Johnsen, Kari; Wollebæk, Dag; Enjolras, Bernard


    In this article, we take issue with the claim by Sunstein and others that online discussion takes place in echo chambers, and suggest that the dynamics of online debates could be more aptly described by the logic of 'trench warfare', in which opinions are reinforced through contradiction as well as confirmation. We use a unique online survey and an experimental approach to investigate and test echo chamber and trench warfare dynamics in online debates. The results show that people do indeed claim to discuss with those who hold opposite views from themselves. Furthermore, our survey experiments suggest that both confirming and contradicting arguments have similar effects on attitude reinforcement. Together, this indicates that both echo chamber and trench warfare dynamics - a situation where attitudes are reinforced through both confirmation and disconfirmation biases - characterize online debates. However, we also find that two-sided neutral arguments have weaker effects on reinforcement than one-sided confirming and contradicting arguments, suggesting that online debates could contribute to collective learning and qualification of arguments.

  12. Electronic Warfare:Issues and Challenges for Emitter Classification

    Directory of Open Access Journals (Sweden)

    Manish Gupta


    Full Text Available Electronic warfare (EW is an important capability that provides advantage to defence forces over their adversaries. Defence forces gather tactical intelligence through EW sensors, which provide the means to counter hostile actions of enemy forces. Functions of an EW system is threat detection and the area surveillance so as to determine the identity of surrounding emitters. Emitter classification system identifies possible threats by analysing intercepted signals. Problem of identifying emitters based on its intercepted signal characteristics is a challenging problem in electronic warfare studies. Major issues and challenges for emitter classification such as drifting of emitter parameters due to aging, operational characteristic of an emitter, i.e., same emitter can operate on multiple bands and multiple pulse repetition frequencies (PRFs are highlighted. A novel approach based on some well-known statistical methods, e.g., regression analysis, hypothesis testing, and discriminent analysis is proposed. The effectiveness of the proposed approach has been tested over ELINT (Electronic Intelligence data and illustrated using simulation data. The proposed approach can play a solution for wide variety of problems in emitter classification in electronic warfare studies.Defence Science Journal, 2011, 61(3, pp.228-234, DOI:

  13. Mustard Group Chemical War Agents from Preventive Medicine Perspective

    Directory of Open Access Journals (Sweden)

    Muharrem Ucar


    Full Text Available Although many preventive efforts and treaties, chemical warfare agents have still been a severe assault form against both military and civilian individuals. The most important chemical warfare agents sulphur mustard and others are easy to handle and cheap those the important reasons to accept sulphur mustard as a chemical warfare agent. Many individuals attacked by sulphur mustard have severe health problems such as respiratory system diseases. After ten years of sulphur mustard exposure, several health problems such as respiratory tract problems (%42.5, eye problems (%40 and other systemic diseases have been observed to insist on induviduals when examined. Exposure of even single sulphur mustard exposure has been seen to result high level of disability and early deaths. In spite of the fact that there is no available antidote and/or remedy against sulphur mustard exposure, our country has an incremental chemical assault threat for both military personels and civilians because of its jeopolitics position. Experimental studies regarding sulphur mustard toxicity will be helpful for novel preventive strategies and antidot devolepment. [TAF Prev Med Bull 2007; 6(3.000: 209-214

  14. Assessing Protection Against OP Pesticides and Nerve Agents Provided by Wild-Type HuPON1 Purified from Trichoplusia ni Larvae or Induced via Adenoviral Infection (United States)


    times the median lethal dose (LD50) of the OP nerve agents tabun (GA), sarin (GB), soman (GD), and cyclosarin (GF), or chlorpyrifos oxon, the toxic...Doctor, M.P. Nambiar, Efficient hydrolysis of the chemical warfare nerve agent tabun by recombinant and purified human and rabbit serum paraoxonase

  15. Status of dental health in chemical warfare victims: The case of Isfahan, Iran

    Directory of Open Access Journals (Sweden)

    Ahmad Mottaghi


    Conclusion: Chemical warfare victims have relatively poor dental/oral health. Chemical injury might cause a dysfunction in saliva secretion, with decrease in saliva secretion increasing the risk for tooth decay and periodontal disorders. Further research is required to find out the exact underlying mechanisms and the factors associated with poor dental/oral health in chemical warfare victims.

  16. Cyber Warfare: China’s Strategy to Dominate in Cyber Space (United States)


    Revolution.‖ 64Jason Fritz, ―How China will use cyber warfare to leapfrog in military competitiveness,‖ Culture Mandala : The Bulletin of the Centre for East...cyber warfare to leapfrog in military competitiveness.‖ Culture Mandala : The Bulletin of the Centre for East-West Culture and Economic Studies 8 no. 1

  17. Investigating the Hydrolysis Reactions of a Chemical Warfare Agent Surrogate. A Systematic Study using 1H, 13C, 17O, 19F, 31P, and 35Cl NMR Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Alam, Todd M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Wilson, Brendan W. [West Virginia Univ., Morgantown, WV (United States)


    During the summer of 2015, I participated in the DHS HS-STEM fellowship at Sandia National Laboratories (SNL, NM) under the supervision of Dr. Todd M. Alam in his Nuclear Magnetic Resonance (NMR) Spectroscopy research group. While with the group, my main project involved pursing various hydrolysis reactions with Diethyl Chlorophosphate (DECP), a surrogate for the agent Sarin (GB). Specifically, I performed different hydrolysis reactions, monitored and tracked the different phosphorous containing species using phosphorous (31P) NMR spectroscopy. With the data collected, I performed kinetics studies mapping the rates of DECP hydrolysis. I also used the NMR of different nuclei such as 1H, 13C, 17O, and 35Cl to help understand the complexity of the reactions that take place. Finally, my last task at SNL was to work with Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) NMR Spectroscopy optimizing conditions for 19F- 31P filtering NMR experiments.

  18. Quantitation of five organophosphorus nerve agent metabolites in serum using hydrophilic interaction liquid chromatography and tandem mass spectrometry


    Hamelin, Elizabeth I.; Schulze, Nicholas D.; Shaner, Rebecca L.; Coleman, Rebecca M.; Lawrence, Richard J.; Crow, Brian S.; Jakubowski, E. M.; Johnson, Rudolph C.


    Although nerve agent use is prohibited, concerns remain for human exposure to nerve agents during decommissioning, research, and warfare. Exposure can be detected through the analysis of the hydrolysis products in urine as well as blood. An analytical method to detect exposure to five nerve agents, including VX, VR (Russian VX), GB (sarin), GD (soman) and GF (cyclosarin), through the analysis of the hydrolysis products, which are the primary metabolites, in serum has been developed and charac...

  19. Multiscale modeling of nerve agent hydrolysis mechanisms: a tale of two Nobel Prizes (United States)

    Field, Martin J.; Wymore, Troy W.


    The 2013 Nobel Prize in Chemistry was awarded for the development of multiscale models for complex chemical systems, whereas the 2013 Peace Prize was given to the Organisation for the Prohibition of Chemical Weapons for their efforts to eliminate chemical warfare agents. This review relates the two by introducing the field of multiscale modeling and highlighting its application to the study of the biological mechanisms by which selected chemical weapon agents exert their effects at an atomic level.

  20. Evidence of VX nerve agent use from contaminated white mustard plants


    Gravett, Matthew R.; Hopkins, Farrha B.; Self, Adam J.; Webb, Andrew J; Timperley, Christopher M.; Baker, Matthew J.


    The Chemical Weapons Convention prohibits the development, production, acquisition, stockpiling, retention, transfer or use of chemical weapons by Member States. Verification of compliance and investigations into allegations of use require accurate detection of chemical warfare agents (CWAs) and their degradation products. Detection of CWAs such as organophosphorus nerve agents in the environment relies mainly upon the analysis of soil. We now present a method for the detection of the nerve a...

  1. Simulant Agent Resistance Test Manikin (SMARTMAN) Testing of Protective Mask Systems (United States)


    The staff will include emergency medical technicians ( EMTs ) qualified in advanced life support. 2.2 Instrumentation. Permissible error...warfare agent DA Department of the Army DTP detailed test plan EMT emergency medical technician FD/SC failure definition/scoring...Institute for Occupational Safety and Health NRT near real time NTA non-traditional agent TOP 08-2-109 16 September 2013 APPENDIX C

  2. Cybersecurity protecting critical infrastructures from cyber attack and cyber warfare

    CERN Document Server

    Johnson, Thomas A


    The World Economic Forum regards the threat of cyber attack as one of the top five global risks confronting nations of the world today. Cyber attacks are increasingly targeting the core functions of the economies in nations throughout the world. The threat to attack critical infrastructures, disrupt critical services, and induce a wide range of damage is becoming more difficult to defend against. Cybersecurity: Protecting Critical Infrastructures from Cyber Attack and Cyber Warfare examines the current cyber threat landscape and discusses the strategies being used by governments and corporatio

  3. Healthcare and warfare. Medical space, mission and apartheid in twentieth century northern Namibia. (United States)

    Nord, Catharina


    In the year 1966, the first government hospital, Oshakati hospital, was inaugurated in northern South-West Africa. It was constructed by the apartheid regime of South Africa which was occupying the territory. Prior to this inauguration, Finnish missionaries had, for 65 years, provided healthcare to the indigenous people in a number of healthcare facilities of which Onandjokwe hospital was the most important. This article discusses these two agents' ideological standpoints. The same year, the war between the South-West African guerrillas and the South African state started, and continued up to 1988. The two hospitals became involved in the war; Oshakati hospital as a part of the South African war machinery, and Onandjokwe hospital as a 'terrorist hospital' in the eyes of the South Africans. The missionary Onandjokwe hospital was linked to the Lutheran church in South-West Africa, which became one of the main critics of the apartheid system early in the liberation war. Warfare and healthcare became intertwined with apartheid policies and aggression, materialised by healthcare provision based on strategic rationales rather than the people's healthcare needs. When the Namibian state took over a ruined healthcare system in 1990, the two hospitals were hubs in a healthcare landscape shaped by missionary ambitions, war and apartheid logic.

  4. Nanowire-based surface-enhanced Raman spectroscopy (SERS) for chemical warfare simulants (United States)

    Hoffmann, J. A.; Miragliotta, J. A.; Wang, J.; Tyagi, P.; Maddanimath, T.; Gracias, D. H.; Papadakis, S. J.


    Hand-held instruments capable of spectroscopic identification of chemical warfare agents (CWA) would find extensive use in the field. Because CWA can be toxic at very low concentrations compared to typical background levels of commonly-used compounds (flame retardants, pesticides) that are chemically similar, spectroscopic measurements have the potential to reduce false alarms by distinguishing between dangerous and benign compounds. Unfortunately, most true spectroscopic instruments (infrared spectrometers, mass spectrometers, and gas chromatograph-mass spectrometers) are bench-top instruments. Surface-acoustic wave (SAW) sensors are commercially available in hand-held form, but rely on a handful of functionalized surfaces to achieve specificity. Here, we consider the potential for a hand-held device based on surface enhanced Raman scattering (SERS) using templated nanowires as enhancing substrates. We examine the magnitude of enhancement generated by the nanowires and the specificity achieved in measurements of a range of CWA simulants. We predict the ultimate sensitivity of a device based on a nanowire-based SERS core to be 1-2 orders of magnitude greater than a comparable SAW system, with a detection limit of approximately 0.01 mg m-3.

  5. China's Use of Cyber Warfare: Espionage Meets Strategic Deterrence

    Directory of Open Access Journals (Sweden)

    Magnus Hjortdal


    Full Text Available This article presents three reasons for states to use cyber warfare and shows that cyberspace is—and will continue to be—a decisive element in China's strategy to ascend in the international system. The three reasons are: deterrence through infiltration of critical infrastructure; military technological espionage to gain military knowledge; and industrial espionage to gain economic advantage. China has a greater interest in using cyberspace offensively than other actors, such as the United States, since it has more to gain from spying on and deterring the United States than the other way around. The article also documents China's progress in cyber warfare and shows how it works as an extension of its traditional strategic thinking and the current debate within the country. Several examples of cyber attacks traceable to China are also presented. This includes cyber intrusions on a nuclear arms laboratory, attacks on defense ministries (including the Joint Strike Fighter and an airbase and the U.S. electric grid, as well as the current Google affair, which has proved to be a small part of a broader attack that also targeted the U.S. Government. There are, however, certain constraints that qualify the image of China as an aggressive actor in cyberspace. Some believe that China itself is the victim of just as many attacks from other states. Furthermore, certain actors in the United States and the West have an interest in overestimating China's capabilities in cyberspace in order to maintain their budgets.

  6. Narrowing the zone of uncertainty between research and development in biological warfare defense. (United States)

    Huxsoll, D L


    Although "research" is not prohibited by the Biological Weapons Convention, States Parties to the Convention have maintained the spirit of the Convention in actions relating to research. The confidence-building measures agreed to at RC2 refer to research facilities, publication of research results, and promotion of contacts between scientists engaged in research related to the Convention. However, assessment of basic research on biological agents is not a productive way to distinguish an offensive from a defensive program. Additionally, if a country were to initiate a biological weapons program, basic research on biological agents may not be necessary. For example, the extensive published research on Bacillus anthracis, both as a cause of anthrax in cattle and other species and as a biological-warfare agent, would enable any motivated group or nation to initiate a biological weapons program that could immediately advance to the development and scale-up stages. Research on biological agents for offensive purposes would be characterized by activities such as selection for growth, virulence, and toxin production; improving stability under varying environmental conditions; and selection of strains that might overcome existing means of prophylaxis and treatment. A biological program with an offensive intent would in most cases be characterized by evidence of development efforts in mass production and dissemination, which are often agent-specific. Thus, an assessment of development may distinguish offensive from defensive programs. If a country were to initiate a biological weapons research program, and were willing to risk worldwide condemnation should existence of such a program become known, it is likely that such a program would include development and production capabilities. If a country were not committed to production capability, there would be no rationale for an offensive biological research that would bring worldwide condemnation. Critics of the U

  7. Chemical Warfare Materiel in Sediment at a Deep-Water Discarded Military Munitions Site (United States)

    Briggs, C. W.; Bissonnette, M. C.; Edwards, M.; Shjegstad, S. M.


    Understanding the release and transformation of chemical agent (CA) at underwater discarded military munitions (DMM) sites is essential to determine the potential risk to human health and impact on the ocean environment; yet few studies have been conducted at sites in excess of 250 m, the depth at which most U.S. CA munitions were disposed. Maritime construction workers installing cables or pipelines at a CA DMM site, as well as fishermen and scientific researchers deploying bottom-contact gear, represent possible exposure pathways to human receptors. The Hawai`i Undersea Military Munitions Assessment (HUMMA) sought to characterize a historic munitions sea-disposal site at depths between 400-650 m. During the 2014 HUMMA Sampling Survey, the Jason 2 remotely operated vehicle was used to collect sediments within two meters of suspected World War II chemical munitions, confirmed to be 100-lb M47 series bombs containing sulfur mustard. When environmental media was brought to the surface, samples were screened for distilled sulfur mustard (HD) and related agent breakdown products (ABP) (collectively referred to as chemical warfare materiel [CWM]). Detectable concentrations of HD and/or its ABP 1,4-dithiane were found in sediments collected at all CA DMM sites; HD was also detected at two control sites. The location and extent of munitions casing deterioration strongly influenced the distribution and level of CWM in sediment. The interior of the casing contained levels of CWM orders of magnitudes higher than that observed in the surrounding sediment at one meter distance, indicating the majority of the CWM is hydrolyzed as it is released from the munitions casing and a fraction of the fill materiel persists in the environment for decades following disposal. Although the potential for future site users to become exposed to CWA in recovered sediments and debris exists, the level of risk is significantly mitigated by the depth and location of the sea-disposal site.

  8. The Third World War? In The Cyberspace. Cyber Warfare in the Middle East.

    Directory of Open Access Journals (Sweden)



    Full Text Available This article aims to provide a brief and comprehensive introduction to the issue of cyber warfare and to display the recent development in this area. Geographically, it focuses on the Middle East region, since the vast majority of the most important recent cyber attacks appeared just in there or were connected to it. The first part of the article tries to define the key notion of cyber warfare, compares it to the standard warfare and presents different types of cyber weapons that are known today. The second part points out examples of the most striking recent cyber attacks and uses them as evidences to demonstrate today's importance and dissemination of cyber warfare. Finally, the article sums up pros and cons of the cyber weapons and, in view of these, predicts a significant increase in their use in any future war conflicts.

  9. Optimizing Armed Forces Capabilities for Hybrid Warfare – New Challenge for Slovak Armed Forces

    Directory of Open Access Journals (Sweden)

    Peter PINDJÁK


    Full Text Available The paper deals with the optimization of military capabilities of the Slovak Armed Forces for conducting operations in a hybrid conflict, which represents one of the possible scenarios of irregular warfare. Whereas in the regular warfare adversaries intend to eliminate the centers of gravity of each other, most often command and control structures, in irregular conflicts, the center of gravity shifts towards the will and cognitive perception of the target population. Hybrid warfare comprises a thoroughly planned combination of conventional military approaches and kinetic operations with subversive, irregular activities, including information and cyber operations. These efforts are often accompanied by intensified activities of intelligence services, special operation forces, and even mercenary and other paramilitary groups. The development of irregular warfare capabilities within the Slovak Armed Forces will require a progressive transformation process that may turn the armed forces into a modern and adaptable element of power, capable of deployment in national and international crisis management operations.

  10. Changing the face of cyber warfare with international cyber defense collaboration

    CSIR Research Space (South Africa)

    Grobler, M


    Full Text Available of the Government, as well as cyber security and cyber warfare acts and the command and control aspects thereof. The research presented is largely theoretical in nature, focusing on recent events in the public international domain....

  11. A Review of Chemical Warfare Agent (CWA) Detector Technologies and Commercial-Off-The-Shelf Items (United States)


    lithium thionyl chloride batteries74 Battery , external power supply of rechargeable battery78 110 (+/-10%) VAC 50/60 Hz or 600 watts77. Operational Life...dioxide battery or 12V power supply6, 39, 40 6 standard ‘C’ alkaline batteries44 Rechargeable lithium -ion battery46 Rechargeable lithium - ion... battery pack51 Lithium manganese dioxide batteries or power supply56 Lithium -sulfur dioxide battery ,

  12. A Survey and Evaluation of Chemical Warfare Agent-Decontaminants and Decontamination (United States)


    Miscellaneous Oxidants--Perchloryl fluoride (C10 3 F ) and dinitro- gen tetroxide (N20 4 ) were developed and tested (31); results indicated that none of...H. * Potassium peroxydisulfate--This compound combined with a silver ion catalyst has been suggested for the decomposition of V, but experimental work...tetramethylethylenedlamine (TMEDA) is 1.0 minute at pH 7.0. Although several diamine - Cu (II) complexes including di-u-dihydroxo-bis-(N, N,N’,N’-tetraethyl

  13. Ram-air sample collection device for a chemical warfare agent sensor (United States)

    Megerle, Clifford A.; Adkins, Douglas R.; Frye-Mason, Gregory C.


    In a surface acoustic wave sensor mounted within a body, the sensor having a surface acoustic wave array detector and a micro-fabricated sample preconcentrator exposed on a surface of the body, an apparatus for collecting air for the sensor, comprising a housing operatively arranged to mount atop the body, the housing including a multi-stage channel having an inlet and an outlet, the channel having a first stage having a first height and width proximate the inlet, a second stage having a second lower height and width proximate the micro-fabricated sample preconcentrator, a third stage having a still lower third height and width proximate the surface acoustic wave array detector, and a fourth stage having a fourth height and width proximate the outlet, where the fourth height and width are substantially the same as the first height and width.

  14. The Utility of Freedom: A Principal-Agent Model for Unconventional Warfare (United States)


    1st ed. (Berkeley, CA: University of California Press, 2009); Melvyn C. Goldstein, The Snow Lion and the Dragon: China, Tibet, and the Dalai Lama ...and equipment to the rebel fighters. This phase ends in March of 1959, with the escape of the Dalai Lama to exile in India.50 The second phase...ends in 1974 when the Dalai Lama ordered the remaining resistance members to lay down their arms and take up the ―long term approach‖ to the Tibetan

  15. Evaluation of Animal and Plant Pathogens as Terrorism and Warfare Agents, Vectors and Pests (United States)


    Acari Arachnida Hyalomma Anatolicumn Anatolicumn Dermacentor andersoni Acari Arachnida Dermacentor varabilis Amblyimma Cajennese Rhipicephalus sanguineus...Mansonia spp. Diptera Insecta Culex spp. Culiseta spp. Pediculus humanus Anopluraa Insect Ixodides Dermacentor spp. Acari Arachnida Rhipicephalus spp

  16. Methyl Salicylate: A Reactive Chemical Warfare Agent Surrogate to Detect Reaction with Hypochlorite (POSTPRINT) (United States)


    acid (Fisher Scientific, Fair Lawn, NJ) was diluted to 1.0 M in water purified by reverse osmosis . Methods. Reactions were initially examined by...reactivity of hypochlorite neutralizants delivered onto a substrate is strongly diffusion limited, an observation likely to be useful as a

  17. In Situ Studies of the Decomposition of Simulated Chemical Warfare Agents on Nanoparticle Catalysts (United States)


    insufficient energy for interdiffusion of Rh into bulk Pt surfaces.9,24,25 In addition, Monte Carlo simulations of a 1000-atom Au(50%)-Pt(50...12949. (22) Hernandez-Fernandez, P.; Rojas, S.; Ocon, P.; de la Fuente , J. L. G.; Fabian, J. S.; Sanza, J.; Pena, M. A.; Garcia-Garcia, F. J

  18. Five-Year Follow-Up of Army Personnel Potentially Exposed to Chemical Warfare Agents (United States)


    21.3 0.93 (0.83-1.04) Neuralgia or neuritis 6.8 6.4 1.05 (0.85-1.30) Any disease of genital organs 6.3 6.6 0.94 (0.76-1.17) Heart disease 1.8 1.8 0.98...Recurrent headaches 46.8 42.0 0.20 Ž:7 14.1 12.8 Migraines 19.0 20.3 0.66 Not answered - - 0.45 Neuralgia or neuritis 6.2 7.5 0.50 Hospitalizations...other cancer, tunity to look at the possible effects of notification on health. The recurrent headache, and neuralgia . Only recurrent headache fact that

  19. Biosensor-Based Detection and Verification System for Bio-Chemical Warfare Agents (United States)


    23 The second alternative detection scheme is gated integration (GI). In GI, the photocurrent from the LAPS is collected on a feedback capacitor ...magnitude of the internal photovoltage can be estimated by dividing the charge output form the LAPS by the magnitude of the insulator capacitor . For the case...uI184eiG)u3 C fousJiojdosi Ioqoeqie3 0. loqia)e 00 Lf ; CJ CS (9s~e~jou */) asuodseU (Silicone) (.002’ Polyester )I I Ir ScreenI (PeCap 7-88/34)I I (.012 "x

  20. Chemical Warfare Agent Surface Adsorption: Hydrogen Bonding of Sarin and Soman to Amorphous Silica (United States)


    small transfer chamber located within the confines of a CWA-certified surety fume hood . Within the main chamber, the sample was mounted on a molybdenum...Particulate silica surface samples were prepared by dispersing silica (200 m2/g, Aerosil fumed silica with a 12 nm average particle diameter) from a

  1. Detection of Biological Warfare Agents in Municipal Tap Water via Standardized Culture Methods (United States)


    0.001 % v/v Tween 80 (Fisher T164). All solutions were prepared in distilled water and filter sterilized. NaPP was made fresh daily, while the sodium...thiosulfate and Tween 80 solutions were stored for no longer than one week at 4 °C. The ultrafiltration apparatus (see Figure) was assembled after...filtration period. When filtration of the 100 L was complete, 150 mL of 0.001 % Tween 80 was aspirated into the filter as a "forward rinse" through the

  2. Chemical Warfare Agent Operational Exposure Hazard Assessment Research: FY07 Report and Analysis (United States)


    accidentally exposed to VX vapor. The method employs GC-MS/MS on a triple quadrupole mass spectrometer using stable isotope dilution for quantitation... Technique for Assessing Exposure to VX via GC-MS/MS Analysis 85 3.3.1 Introduction 85 3.3.2 Materials and Methods 85 3.3.3 Results and Discussion 90...guinea pigs were anesthetized using isoflurane (3% induction, 15-2% maintenance; with oxygen). All procedures were performed using aseptic technique

  3. An Evaluation of Bioregulators/Modulators as Terrorism and Warfare Agents (United States)


    brain should have receptor sites for alkaloids from the opium poppy led to the discovery of a family of natural painkillers , the endorphins (from...traced in human body. In each case a clandestine application of such substances can lead to death - "killing without a trace". Although the use of...the possibility for direct delivery of toxin or bioregulator to the human target or they could be used to transfer the toxin or bioregulator genes to

  4. Photoassisted reaction of chemical warfare agent VX droplets under UV light irradiation. (United States)

    Zuo, Guo-Min; Cheng, Zhen-Xing; Li, Guo-Wen; Wang, Lian-Yuan; Chen, Hong


    A photoassisted reaction of O-ethyl S-[2-(diisopropylamino) ethyl] methylphosphonothioate (VX) droplets in air was carried out. The experimental results indicated that VX droplets could be easily and chemically transformed into other compounds under irradiation of a germicidal lamp over sufficient time. Quantum chemical calculation results demonstrated that UV light less than 278 nm wavelength could possibly initiate photoreaction of VX and that both P-S and P=O bonds in the VX molecule were lengthened. The identification of reaction products by gas and liquid chromatography mass spectroscopy and NMR revealed that the VX molecule in air under UV light irradiation could undergo isomerization of S-esters to O-esters, cleavage of P-S, S-C, and C-N bonds, and ozonation of tertiary amines.

  5. Oxidative degradation of chemical warfare agents in water by bleaching powder. (United States)

    Qi, Lihong; Zuo, Guomin; Cheng, Zhenxing; Zhu, Haiyan; Li, Shanmao


    Degradation of sulfur mustard (HD), S-2-(di-isopropylamino)ethyl O-ethyl methylphosphonothioate (VX) and Soman (GD) in water by bleaching powder was investigated. The degradation products were comprehensively analyzed by gas chromatography/mass spectrometry (GC/MS), liquid chromatography/mass spectrometry (LC/MS) and ion chromatography. Degradation pathways were deduced based on the identified products. The product analysis results indicated that HD could be degraded through oxidation and chlorination reactions, and a small portion of sulfur atoms could be mineralized into SO(4)(2-) ion. Oxidative degradation of VX could finally generate O-ethyl methylphosphonate acid (EMPA), sulfonic acids, SO(4)(2-) and NO(3)(-) ions. GD would be converted into non-toxic pinacolyl methylphosphonate via nucleophilic substitution.

  6. Using Agent Based Distillation to Explore Issues Related to Asymmetric Warfare (United States)


    ONERA -CT/DTIM/SER 2 Avenue E. Belin 31055 Toulouse Cedex France, ABSTRACT In this paper...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) ONERA -CT/DTIM/SER 2 Avenue E. Belin 31055 Toulouse Cedex France 8. PERFORMING ORGANIZATION REPORT

  7. Diagnosis of Exposure to Chemical Warfare Agents: A Comprehensive Literature Survey 1990-2005 (United States)


    30S,02S," O2S, CH2 CH 2SCH3 CH 2CH2 SOCH 3 CH2 CH 2SCH 3 (2) (3) (10) Single stage GC-MS analysis, using positive ammonia CI and SIM of [M+NH 4]+, m...methodology, N7-HETE- Gua was detected in the spleen and liver of rats exposed percutaneously to sulfur mustard (Rao et al., 2002). b) Other physicochemical

  8. Computational Enzymology and Organophosphorus Degrading Enzymes: Promising Approaches Toward Remediation Technologies of Warfare Agents and Pesticides. (United States)

    Ramalho, Teodorico C; de Castro, Alexandre A; Silva, Daniela R; Silva, Maria Cristina; Franca, Tanos C C; Bennion, Brian J; Kuca, Kamil


    The re-emergence of chemical weapons as a global threat in hands of terrorist groups, together with an increasing number of pesticides intoxications and environmental contaminations worldwide, has called the attention of the scientific community for the need of improvement in the technologies for detoxification of organophosphorus (OP) compounds. A compelling strategy is the use of bioremediation by enzymes that are able to hydrolyze these molecules to harmless chemical species. Several enzymes have been studied and engineered for this purpose. However, their mechanisms of action are not well understood. Theoretical investigations may help elucidate important aspects of these mechanisms and help in the development of more efficient bio-remediators. In this review, we point out the major contributions of computational methodologies applied to enzyme based detoxification of OPs. Furthermore, we highlight the use of PTE, PON, DFP, and BuChE as enzymes used in OP detoxification process and how computational tools such as molecular docking, molecular dynamics simulations and combined quantum mechanical/molecular mechanics have and will continue to contribute to this very important area of research.

  9. Prolonged Inhibition of Motor Activity Following Repeated Exposure to Low Levels of Chemical Warfare Agent VX (United States)


    Anxious mice tend to avoid the brightly lit center of the maze, and display thigmotaxis (wall following), in which they closely walk along the...analysis of the mouse open field test: effects of diazepam , chlordiazepoxide and an extremely low frequency pulsed magnetic field, Neurosci Biobehav

  10. Bio Warfare and Terrorism: Toxins and Other Mid-Spectrum Agents (United States)


    bacteria or fungi or weaken nium salts), nonionic (e.g., alkyl polyglycosides, the cell walls so that they are more susceptible to alcohol ethoxylates ...alkylphenol ethoxylates ), and other classes of biocides (see below). Sodium zwitterionic.

  11. Surface with two paint strips for detection and warning of chemical warfare and radiological agents (United States)

    Farmer, Joseph C.


    A system for warning of corrosion, chemical, or radiological substances. The system comprises painting a surface with a paint or coating that includes an indicator material and monitoring the surface for indications of the corrosion, chemical, or radiological substances.

  12. Comparative Analysis of Two Biological Warfare Air Samplers Using Live Surrogate Agents (United States)


    bacteriophage. First, a 1L sterile Nalgene® bottle was used then 20 mL of MS2 fitrate (3 x 109) was mixed with 500 mL of Luria -Bertani broth media...broth CFU colony-forming units IPA isopropyl alcohol LBA luria -bertani agar LBB luria -bertani broth PBS phosphate buffer saline PFU

  13. Improving Blood Monitoring of Enzymes as Biomarkers of Risk from Anticholinergic Pesticides and Chemical Warfare Agents (United States)


    One approach would be to use the colorimetric two substrate ( diazinon -oxon and paraoxon) PON1 assay (Richter, et al., 2004, Costa, et al., 2005a...and, its limited usefulness as a test of liver function. J Lab Clin Med 40:692–702. Harris, E.K. (1974). Effects of intra- and interindividual varia...Vorhaus, L.J., II, Scudamore, H.H., Kark, R.M. (1950). Measurement of serum cholinesterase activty in the study of disease of the liver and biliary

  14. Biodegradation of an Organophosphate Chemical Warfare Agent Simulant by Activated Sludge with Varying Solid Retention Times (United States)


    0.72 g Na3NTA * 2H2O , 0.3 g Na3EDTA * 4H2O, 3.0 g FeCl3 * 6H2O, 0.5 g H3BO3, 0.3 g ZnSO4 * 7H2O, 0.24 g MnCl2 * 4H2O, 0.14 g CuSO4 * 5H2O, 0.06 g KI...through reactions shown in equations 2-4. 12 NH3 + O2 + 2e - +2H + - -> NH2OH + H2O (2) NH2OH + H2O + 1/2 O2--> NO 2- + 2H2O + H + (3...1.25 g NaCH3COO, 2.26 g NH4Cl, 6.86 g MgCl2 * 6H2O, 1.72 g CaCl2 * 2H2O , 0.6675 g KH2PO4 and 20 mL of a trace element solution adapted from

  15. A Review of the Disruptive Potential of Botulinum Neurotoxins as Chemical Warfare Agents (United States)


    dangerous chemical weapon (persistence in vivo, exceedingly high potency, ease of distribution and ease of production) also make it highly...caused by ingestion of botulinum neurotoxin (BoNT) was first described as “ sausage poisoning” in 1820 and attributed to a bacterium in 1897 [1]. We...intoxication of susceptible hosts invariably results in neuromuscular paralysis. The same characteristics that make the BoNTs the most lethal substances

  16. Marital Relationship and Its Associated Factors in Veterans Exposed to High Dose Chemical Warfare Agents

    Directory of Open Access Journals (Sweden)

    Shervin Assari


    Full Text Available Objective: The aim of this study was to determine the associates of marital relationship in mustard exposed veterans.Materials and Methods: Two hundred ninety two married Iranian mustard exposed veterans, who had been exposed to single high dose mustard gas in Iraq-Iran war, were assessed for marital adjustment with Revised Dyadic Adjustment Scale (RDAS. Census sampling was done. The patients' quality of life (SF-36, spirometric measures and war related data were also extracted.Results: A total of 189 subjects (65% completed our study. The mean (±SD of the RDAS Total score, RDAS Dyadic Consensus , RDAS Affectional Expression, RDAS Dyadic Satisfaction , and RDAS Dyadic Cohesion were 50.61 (8.16, 16.67 (2.77, 7.62 (1.84, 14.76 (3.39, and 11.54 (3.79, respectively. RDAS Dyadic satisfaction was correlated with SF-36 and all its sub-scores (p<0.05. RDAS total score showed significant correlation with SF-36 total score and most of its sub-scores (p<0.05. RDAS affective expression was significantly correlated with role limitation, social function, general mental health, vitality, General health perceptions, physical composite score (PCS and mental composite score (MCS (p<0.05. RDAS dyadic consensus was not correlated with any SF-36 sub-scores.Conclusion: Veterans health team including physicians, psychologists and/or psychiatrists should know that poorer marital satisfaction is linked with lower quality of life scores, late after mustard exposure, although marital relationship is independent of spirometric findings, age, duration from exposure and comorbidity score.

  17. Chiral Separation of G-type Chemical Warfare Nerve Agents via Analytical Seupercritical Fluid Chromatography (United States)


    by HPLC have not been well characterized . Supercritical fluid chromatography (SFC) is a well- established chiral chromatography technology that offers...smoothed chromatograms. For presentation purposes only smoothed chromatograms are shown. Chromatographic Characterization Chromatography parameters were...under these conditions (data not shown). Various other polysaccharide -type chiral columns (Chiralpak AD-H, Chiralcel OJ-RH, Chiralpak IB) were tested

  18. A Better State of War: Surmounting the Ethical Cliff in Cyber Warfare (United States)


    Unlike landmines, for example, that litter historical battlefields to this day, cyber weapons offer a more hygienic approach to warfare. In...institutions have protected civilians from harm through established regulations and norms ranging from merchant shipping protection under the law of...targeted the Laconia, a merchant vessel, in 1942.80 Citizens engaged in cyber warfare, however, may be targeted with commensurate cyber weapons

  19. Electronic Warfare: Rethinking the Importance of Its Role In Military Operations (United States)


    EW mindset changes. 15. SUBJECT TERMS Electronic Warfare, Vulnerability, Military, Threat , Technology, Technological 16. SECURITY...Signature: Kevin nernen, C USAF Corn i e Signatu P er e, , C Directo JointA ancedWarfighting Signature: 10 June 2016 Thesis Advisor: Approved by: School...Electronic warfare support actions taken to identify, locate sources of energy emitted by enemy systems for the purpose of providing threat warning

  20. ‘Lest we forget’*: a veteran and son share a ‘warfare tourism’ experience


    Fallon, Paul; Robinson, Peter


    Warfare tourism’ represents an increasingly significant dimension of contemporary tourism. This paper provides a fresh perspective on participation in ‘warfare tourism’ by investigating the behaviour and experiences of a living veteran and his son returning to two theatres of war in which the veteran had served in the Royal Navy during the Second World War. Active interviews with the two family members were used to gather rich data regarding the two extended trips, which had been funded by ‘H...

  1. Defesa química: histórico, classificação dos agentes de guerra e ação dos neurotóxicos

    Directory of Open Access Journals (Sweden)

    Gustavo Rocha Silva


    Full Text Available Chemical agents are substances used for their toxic effects on humans, animals and plants. The main objective of chemical defense is to develop systems that reduce these effects while minimizing impact on the operational capacity of military troops. In this work, a report on the development of chemical warfare agents since the First World War and their classification is presented. Special attention is given to neurotoxic agents, the most lethal group of chemical agents known to date.

  2. Agroterrorism, Biological Crimes, and Biological Warfare Targeting Animal Agriculture

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Terry M.; Logan-Henfrey, Linda; Weller, Richard E.; Kellman, Brian


    There is a rising level of concern that agriculture might be targeted for economic sabotage by terrorists. Knowledge gathered about the Soviet Union biological weapons program and Iraq following the Gulf War, confirmed that animals and agricultural crops were targets of bioweapon development. These revelations are particularly disturbing in light of the fact that both countries are States Parties to the Biological and Toxin Weapons Convention that entered into force in 1975. The potential for misusing biotechnology to create more virulent pathogens and the lack of international means to detect unethical uses of new technologies to create destructive bioweapons is of increasing concern. Disease outbreaks, whether naturally occurring or intentionally, involving agricultural pathogens that destroy livestock and crops would have a profound impact on a country's infrastructure, economy and export markets. This chapter deals with the history of agroterrorism, biological crimes and biological warfare directed toward animal agriculture, specifically, horses, cattle, swine, sheep, goats, and poultry.


    Directory of Open Access Journals (Sweden)

    Gheorghe MINCULETE


    Full Text Available The military joint operations of the future are characterized by large concentrations of forces and conventional means on the directions that permit the exploitation of the technological superiority and the manifestation of the offensive spirit of the commanders of the joint operation force groups. Having in mind the fact that the relation between the combatant forces and the logistic ones will shift more and more in favour of the latter, the aforementioned operations will be usually supported by modern flexible logistic structures. The constituted force groups will have a significant joint force character, ensuring superior quality of the troops’ combat training, both at individual level and collective level of units and large units. The current article presents innovative aspects of focused logistics, adapted for the modern warfare, which should be designed and achieved in order to increase the operational potential of the joint force groups.

  4. Book Review: Conquest in Cyberspace: National Security and Information Warfare

    Directory of Open Access Journals (Sweden)

    Gary C. Kessler


    Full Text Available Libicki, M.C. (2007. Conquest in Cyberspace: National Security and Information Warfare. New York: Cambridge University Press. 323 pages, ISBN: 978-0-521-69214-4 (paper, US$80Reviewed by Gary C. Kessler (gary.kessler@champlain.eduMany books -- and even movies ("Live Free or Die Hard" -- are based upon the premise of an impending information war. In these scenarios -- made all too plausible by the increased frequency with which we read about and experience major information security incidents -- a Bad Guy exploits known computer security vulnerabilities in order to control major national infrastructures via the Internet so as to reap financial, economic, and/or personal power.(see PDF for full review

  5. Spectroscopic investigations of surface deposited biological warfare simulants (United States)

    Barrington, Stephen J.; Bird, Hilary; Hurst, Daniel; McIntosh, Alastair J. S.; Spencer, Phillippa; Pelfrey, Suzanne H.; Baker, Matthew J.


    This paper reports a proof-of-principle study aimed at discriminating biological warfare (BW) simulants from common environmental bacteria in order to differentiate pathogenic endospores in situ, to aid any required response for hazard management. We used FTIR spectroscopy combined with multivariate analysis; FTIR is a versatile technique for the non-destructive analysis of a range of materials. We also report an evaluation of multiple pre-processing techniques and subsequent differences in cross-validation accuracy of two pattern recognition models (Support Vector Machines (SVM) and Principal Component - Linear Discriminant Analysis (PC-LDA)) for two classifications: a two class classification (Gram + ve spores vs. Gram -ve vegetative cells) and a six class classification (bacterial classification). Six bacterial strains Bacillus atrophaeus, Bacillus thuringiensis var. kurstaki, Bacillus thuringiensis, Escherichia coli, Pantaeoa agglomerans and Pseudomonas fluorescens were analysed.

  6. Technological, military and social causes for the application of cyber warfare

    Directory of Open Access Journals (Sweden)

    Dragan D. Mladenović


    Full Text Available Cyber warfare is a specific new form of military conflicts the use of which is growing rapidly in the international community. However, its nature is specific and differs from all previously known forms of warfare. For the purpose of clear understanding of the nature of cyber warfare, this paper covers the basic groups of preconditions for its broad application and fast development from technological, military and social aspects. Understanding the true nature of cyber warfare is a necessary condition for building national capacities for its application that are military justified and harmonized with the international law. The paper explores the characteristic instances of cyber warfare, ranging from information propaganda to physical destruction, with the goal to determine guidelines for the possible development of cyber capacities at the national level. Based on the analysis of previous cyber warfare cases, a prediction of future development directions is made and the necessity to apply suitable methods and techniques for defense against them is analyzed.

  7. A Survey of Game Theoretic Approaches to Modelling Decision-Making in Information Warfare Scenarios

    Directory of Open Access Journals (Sweden)

    Kathryn Merrick


    Full Text Available Our increasing dependence on information technologies and autonomous systems has escalated international concern for information- and cyber-security in the face of politically, socially and religiously motivated cyber-attacks. Information warfare tactics that interfere with the flow of information can challenge the survival of individuals and groups. It is increasingly important that both humans and machines can make decisions that ensure the trustworthiness of information, communication and autonomous systems. Subsequently, an important research direction is concerned with modelling decision-making processes. One approach to this involves modelling decision-making scenarios as games using game theory. This paper presents a survey of information warfare literature, with the purpose of identifying games that model different types of information warfare operations. Our contribution is a systematic identification and classification of information warfare games, as a basis for modelling decision-making by humans and machines in such scenarios. We also present a taxonomy of games that map to information warfare and cyber crime problems as a precursor to future research on decision-making in such scenarios. We identify and discuss open research questions including the role of behavioural game theory in modelling human decision making and the role of machine decision-making in information warfare scenarios.

  8. Editorial: Discovery from Lake Turkana and History of Human Warfare

    Directory of Open Access Journals (Sweden)

    Professor S. P. Singh, Ph.D.


    Full Text Available Very interesting finds have come to light of violently killed humans from Lake Turkana in the Kenyan Rift Valley around 10000 years ago. A stunning discovery of skeletons of 27 persons who are believed to have been killed at the same time and are supposed to have suffered violent wounds has been reported recently (Nature 529, 394–398, 21 January 2016. These finds belong to a period of late Pleistocene/early Holocene of the hunter-gatherer societies from Nataruk. Among the victims were men, women and children. The individuals were killed with projectiles and blunt weapons. These skeletons were found in the lagoon and were preserved very nicely. Such type of mass killing probably could never happen as a consequence of intra-group conflict. The evidence seems to be towards warfare and aggression in ancient societies. The experts ruled out the possibility of a cemetery and ceremonial burial. This discovery of 27 skeletons points to the fact that there may have been more causalities and many individuals might have escaped death at that time. According to one of the co-authors of this research Dr. R.A. Foley, the groups were elatively more densely packed populations than the hunter gatherers and had more chances of having inter-group conflicts because of sharing the resources which would have been plentiful near the lagoons and water bodies. Violence probably has been in the instinct of early humans and that the warfare among humans has a history of 10000 years or even earlier.

  9. A Square Peg in a Round Hole: A Case Study of Center Gravity Application in Counter Insurgency Warfare (United States)


    D.C.: Potomac Books, 2010. Griffith, Samuel B. The Illustrated Art of War. New York: Oxford University Press, 2005. Guevara , Ernesto Che, Brian... Guevara provided another approach to insurgency, encapsulated in the concept of the foco, which he described in his 1960 work Guerrilla Warfare. The... Guevara , Guerrilla Warfare, edited by Brian Loveman and Thomas Davies, (Oxford: SR Books, 1997), 7. 21 Guevara , Guerrilla Warfare, 256. 22 Guevara

  10. Introduction of Peripheral Carboxylates to Decrease the Charge on Tm(3+) DOTAM-Alkyl Complexes: Implications for Detection Sensitivity and in Vivo Toxicity of PARACEST MRI Contrast Agents. (United States)

    Suchý, Mojmír; Milne, Mark; Elmehriki, Adam A H; McVicar, Nevin; Li, Alex X; Bartha, Robert; Hudson, Robert H E


    A series of structurally modified Tm(3+) DOTAM-alkyl complexes as potential PARACEST MRI contrast agents has been synthesized with the aim to decrease the overall positive charge associated with these molecules and increase their biocompatibility. Two types of structural modification have been performed, an introduction of terminal carboxylate arms to the alkyl side chains and a conjugation of one of the alkyl side chains with aspartic acid. Detailed evaluation of the magnetic resonance imaging chemical exchange contrast associated with the structurally modified contrast agents has been performed. In contrast to the acutely toxic Tm(3+) DOTAM-alkyl complexes, the structurally modified compounds were found to be tolerated well during in vivo MRI studies in mice; however, only the aspartic acid modified chelates produced an amide proton-based PARACEST signal.

  11. Spectra from 2.5-15 {mu}m of tissue phantom materials, optical clearing agents and ex vivo human skin: implications for depth profiling of human skin

    Energy Technology Data Exchange (ETDEWEB)

    Viator, John A [Beckman Laser Institute, University of California, 1002 Health Sciences Road East, Irvine, CA (United States); Choi, Bernard [Beckman Laser Institute, University of California, 1002 Health Sciences Road East, Irvine, CA (United States); Peavy, George M [Beckman Laser Institute, University of California, 1002 Health Sciences Road East, Irvine, CA (United States); Kimel, Sol [Beckman Laser Institute, University of California, 1002 Health Sciences Road East, Irvine, CA (United States); Nelson, J Stuart [Beckman Laser Institute, University of California, 1002 Health Sciences Road East, Irvine, CA (United States)


    Infrared measurements have been used to profile or image biological tissue, including human skin. Usually, analysis of such measurements has assumed that infrared absorption is due to water and collagen. Such an assumption may be reasonable for soft tissue, but introduction of exogenous agents into skin or the measurement of tissue phantoms has raised the question of their infrared absorption spectrum. We used Fourier transform infrared spectroscopy in attenuated total reflection mode to measure the infrared absorption spectra, in the range of 2-15 {mu}m, of water, polyacrylamide, Intralipid, collagen gels, four hyperosmotic clearing agents (glycerol, 1,3-butylene glycol, trimethylolpropane, Topicare{sup TM}), and ex vivo human stratum corneum and dermis. The absorption spectra of the phantom materials were similar to that of water, although additional structure was noted in the range of 6-10 {mu}m. The absorption spectra of the clearing agents were more complex, with molecular absorption bands dominating between 6 and 12 {mu}m. Dermis was similar to water, with collagen structure evident in the 6-10 {mu}m range. Stratum corneum had a significantly lower absorption than dermis due to a lower content of water. These results suggest that the assumption of water-dominated absorption in the 2.5-6 {mu}m range is valid. At longer wavelengths, clearing agent absorption spectra differ significantly from the water spectrum. This spectral information can be used in pulsed photothermal radiometry or utilized in the interpretation of reconstructions in which a constant {mu}{sub ir} is used. In such cases, overestimating {mu}{sub ir} will underestimate chromophore depth and vice versa, although the effect is dependent on actual chromophore depth. (note)

  12. Age-Related Inducibility of Carboxylesterases by the Antiepileptic Agent Phenobarbital and Implications in Drug Metabolism and Lipid Accumulation 1, 2 (United States)

    Xiao, Da; Chen, Yi-Tzai; Yang, Dongfang; Yan, Bingfang


    Carboxylesterases (CES) constitute a class of hydrolytic enzymes that play critical roles in drug metabolism and lipid mobilization. Previous studies with a large number of human liver samples have suggested that the inducibility of carboxylesterases is inversely related with age. To directly test this possibility, neonatal (10 days of age) and adult mice were treated with the antiepileptic agent phenobarbital. The expression and hydrolytic activity were determined on six major carboxylesterases including ces1d, the ortholog of human CES1. Without exception, all carboxylesterases tested were induced to a greater extent in neonatal than adult mice. The induction was detected at mRNA, protein and catalytic levels. Ces1d was greatly induced and found to rapidly hydrolyze the antiplatelet agent clopidogrel and support the accumulation of neutral lipids. Phenobarbital represents a large number of therapeutic agents that induce drug metabolizing enzymes and transporters in a species-conserved manner. The higher inducibility of carboxylesterases in the developmental age likely represents a general phenomenon cross species including human. Consequently, individuals in the developmental age may experience greater drug-drug interactions. The greater induction of ces1d also provides a molecular explanation to the clinical observation that children on antiepileptic drugs increase plasma lipids. PMID:22513142

  13. Catalytic bioscavengers in nerve agent poisoning: A promising approach? (United States)

    Worek, Franz; Thiermann, Horst; Wille, Timo


    The repeated use of the nerve agent sarin against civilians in Syria in 2013 emphasizes the continuing threat by chemical warfare agents. Multiple studies demonstrated a limited efficacy of standard atropine-oxime treatment in nerve agent poisoning and called for the development of alternative and more effective treatment strategies. A novel approach is the use of stoichiometric or catalytic bioscavengers for detoxification of nerve agents in the systemic circulation prior to distribution into target tissues. Recent progress in the design of enzyme mutants with reversed stereo selectivity resulting in improved catalytic activity and their use in in vivo studies supports the concept of catalytic bioscavengers. Yet, further research is necessary to improve the catalytic activity, substrate spectrum and in vivo biological stability of enzyme mutants. The pros and cons of catalytic bioscavengers will be discussed in detail and future requirements for the development of catalytic bioscavengers will be proposed.

  14. Tutorial on agent-based modeling and simulation.

    Energy Technology Data Exchange (ETDEWEB)

    Macal, C. M.; North, M. J.; Decision and Information Sciences


    Agent-based modeling and simulation (ABMS) is a new approach to modeling systems comprised of autonomous, interacting agents. ABMS promises to have far-reaching effects on the way that businesses use computers to support decision-making and researchers use electronic laboratories to support their research. Some have gone so far as to contend that ABMS is a third way of doing science besides deductive and inductive reasoning. Computational advances have made possible a growing number of agent-based applications in a variety of fields. Applications range from modeling agent behavior in the stock market and supply chains, to predicting the spread of epidemics and the threat of bio-warfare, from modeling consumer behavior to understanding the fall of ancient civilizations, to name a few. This tutorial describes the theoretical and practical foundations of ABMS, identifies toolkits and methods for developing ABMS models, and provides some thoughts on the relationship between ABMS and traditional modeling techniques.

  15. Formation of pyrophosphate-like adducts from nerve agents sarin, soman and cyclosarin in phosphate buffer: implications for analytical and toxicological investigations. (United States)

    Gäb, Jürgen; John, Harald; Blum, Marc-Michael


    Phosphate buffer is frequently used in biological, biochemical and biomedical applications especially when pH is to be controlled around the physiological value of 7.4. One of the prerequisites of a buffer compound among good buffering capacity and pH stability over time is its non-reactivity with other constituents of the solution. This is especially important for quantitative analytical or toxicological assays. Previous work has identified a number of amino alcohol buffers like TRIS to react with G-type nerve agents sarin, soman and cyclosarin to form stable phosphonic diesters. In case of phosphate buffer we were able to confirm not only the rapid hydrolysis of these agents to the respective alkyl methylphosphonates but also the formation of substantial amounts of pyrophosphate-like adducts (phosphorylated methylphosphonates), which very slowly hydrolyzed following zero-order kinetics. This led to a complex mixture of phosphorus containing species with changing concentrations over time. We identified the molecular structure of these buffer adducts using 1D ¹H-³¹P HSQC NMR and LC-ESI-MS/MS techniques. Reaction rates of adduct formation are fast enough to compete with hydrolysis in aqueous solution and to yield substantial amounts of buffer adduct over the course of just a couple of minutes. Possible reaction mechanisms are discussed with respect to the formation and subsequent hydrolysis of the pyrophosphate-like compounds as well as the increased rate of hydrolysis of the nerve agent to the corresponding alkyl methylphosphonates. In summary, the use of phosphate buffer for the development of new assays with sarin, soman and cyclosarin is discouraged. Already existing protocols should be carefully reexamined on an individual basis.

  16. Cyclosarin-An Organophosphate Nerve Agent

    Directory of Open Access Journals (Sweden)

    G. Krejcova


    Full Text Available Organophosphorus compounds ascribed to as nerve agents (sarin, soman, tabun, cyclosarin are highly toxic, and are considered to be the most dangerous chemical compounds. All apparently share a common mechanism of cholinesterase inhibition and can cause similar sv.m .ot oms. The standard therapy, in the case of organophosphorus poisoning, has the prophylactic use of reversibly acting AChE inhibitors and antidotal administration of AChE reactivators-oximes. Unfortunately, none of these oximes can be regarded as a broad spectrum antidote, ie, effective against all nerve agents. While the presently available oximes (pralidoxime, ohidoxime are not considered to be sufficiently effective against nerve agents, especially in the case of soman poisoning, the H oximes (HI-6, HLo7 appear to,be very promising antidotes against nerve agents because these are able to protect the experimental animals from toxic effects and improve survival of animals poisoned with supralethal doses. A lot of research has been pursued on the treatment of sarin, soman, and tabun, but cyclosarin was not considered for such a study for a long time. Recently, attention of researchers has also turned to cyclosarin because of its potential use as a chemical warfare agent. Cyclosarin is highly toxic organophosphorus compound which is resistant to conventional oxime therapy. This paper reviews the latest positionof cyclosarin in standpoint of medical treatment by various reactivators considering the ability of various oximes, HI-6, HS-6, BI-6, and KO33 of their reactivation potency.

  17. Mutagenesis of organophosphorus hydrolase to enhance hydrolysis of the nerve agent VX. (United States)

    Gopal, S; Rastogi, V; Ashman, W; Mulbry, W


    Organophosphorus hydrolase (OPH) is capable of hydrolyzing a wide variety of organophosphorus pesticides and chemical warfare agents. However, the hydrolytic activity of OPH against the warfare agent VX is less than 0.1% relative to its activity against parathion and paraoxon. Based on the crystal structure of OPH and the similarities it shares with acetylcholinesterase, eight OPH mutants were constructed with the goal of increasing OPH activity toward VX. The activities of crude extracts from these mutants were measured using VX, demeton-S methyl, diisopropylfluoro-phosphate, ethyl parathion, paraoxon, and EPN as substrates. One mutant (L136Y) displayed a 33% increase in the relative VX hydrolysis rate compared to wild type enzyme. The other seven mutations resulted in 55-76% decreases in the relative rates of VX hydrolysis. There was no apparent relationship between the hydrolysis rates of VX and the rates of the other organophosphorus compounds tested.

  18. Hydrolysis of DFP and the Nerve Agent (S)-Sarin by DFPase Proceeds Along Two Different Reaction Pathways: Implica-tions for Engineering Bioscavengers

    Energy Technology Data Exchange (ETDEWEB)

    Wymore, Troy W [ORNL; Langan, Paul [ORNL; Smith, Jeremy C [ORNL; Field, Martin J. [Institut de Biologie Structurale Jean-Pierre Ebel; Parks, Jerry M [ORNL


    Organophosphorus (OP) nerve agents such as (S)-sarin are among the most highly toxic compounds that have been synthesized. Engineering enzymes that catalyze the hydrolysis of nerve agents ( bioscavengers ) is an emerging prophylactic approach to diminishing their toxic effects. Although its native function is not known, diisopropyl fluorophosphatase (DFPase) from Loligo vulgaris catalyzes the hydrolysis of OP compounds. Here, we investigate the mechanisms of diisopropylfluorophosphate (DFP) and (S)-sarin hydrolysis by DFPase with quantum mechanical/molecular mechanical (QM/MM) umbrella sampling simulations. We find that the mechanism for hydrolysis of DFP involves nucleophilic attack by Asp229 on phosphorus to form a pentavalent intermediate. P F bond dissociation then yields a phosphoacyl enzyme intermediate in the rate-limiting step. The simulations suggest that a water molecule, coordinated to the catalytic Ca2+, donates a proton to Asp121 and then attacks the tetrahedral phosphoacyl intermediate to liberate the diisopropylphosphate product. In contrast, the calculated free energy barrier for hydrolysis of (S)-sarin by the same mechanism is highly unfavorable, primarily due to the instability of the pentavalent phosphoenzyme species. Instead, simulations suggest that hydrolysis of (S)-sarin proceeds by a mechanism in which Asp229 could activate an intervening water molecule for nucleophilic attack on the substrate. These findings may lead to improved strategies for engineering DFPase and related six-bladed -propeller folds for more efficient degradation of OP compounds.

  19. An electronic nose for the detection of Sarin, Soman and Tabun mimics and interfering agents



    An electronic nose system (E-nose) with metal oxide semiconductor sensors (MOS) has been designed to discriminate and quantify different chemical warfare agents (CWA) mimics. The E-nose consists of an array of commercial MOS for different gases, two sensors for temperature sensing, a sample handling system, a data acquisition system and a laptop with the data acquisition system control. With this device, discrimination studies have been carried out to detect specific CWA simulants...

  20. Robust Parameter Design for Agent-Based Simulation Models With Application in a Cultural Geography Model (United States)


    Ajzen , I. (2006). Theory of planned behavior . Retrieved May 24, 2010, from Alt, J. K., Jackson, L. A., Hudak...Cultural Geography, Agent-Based Model (ABM), Irregular Warfare (IW), Theory of planned Behavior (TpB), Baysian Belief Nets (BBN), Counterinsurgency...Strategic Multi-layered Assessment SSTR Security, Stability, Transition and Reconstruction Operations TPB Theory of Planned Behavior TRAC-MTRY

  1. Molecular Evolution of Human PON to Design Enhanced Catalytic Efficiency for Hydrolysis of Nerve Agents (United States)


    Sussman, J.L., Tawfik, D.S. The use of recombinant paraoxonases as bioscavengers for the pretreatment/treatment of organophosphate poisoning , 13th...2006). 10. Bird, S.B., Dawson, A. & Ollis, D. Enzymes and bioscavengers for prophylaxis and treatment of organophosphate poisoning . Front. Biosci...intercepting both existing and emerging organophosphate -based chemical warfare nerve agents (CWNA). The 5 years of performance under this project

  2. Molecular Evolution of Human PON to Design Enhanced Catalytic Efficiency for Hydrolysis of Nerve Agents (United States)


    biomolecules that can intercept both existing and emerging organo - phosphate-based chemical warfare nerve agents (CWNA). All 5th year milestones have been met...w e have demonstrated the potential of direct ed evolution, combining random and designed mutations based on 3D struct ures, to generate m utants of...I., Harel, M., Rosenberry, T.L. & Sussman, J.L. (2010). “Acetylcholinesterase: From 3D structure to function ” Chem Biol Interact, 187, 10-22

  3. Passive front-ends for wideband millimeter wave electronic warfare (United States)

    Jastram, Nathan Joseph

    This thesis presents the analysis, design and measurements of novel passive front ends of interest to millimeter wave electronic warfare systems. However, emerging threats in the millimeter waves (18 GHz and above) has led to a push for new systems capable of addressing these threats. At these frequencies, traditional techniques of design and fabrication are challenging due to small size, limited bandwidth and losses. The use of surface micromachining technology for wideband direction finding with multiple element antenna arrays for electronic support is demonstrated. A wideband tapered slot antenna is first designed and measured as an array element for the subsequent arrays. Both 18--36 GHz and 75--110 GHz amplitude only and amplitude/phase two element direction finding front ends are designed and measured. The design of arrays using Butler matrix and Rotman lens beamformers for greater than two element direction finding over W band and beyond using is also presented. The design of a dual polarized high power capable front end for electronic attack over an 18--45 GHz band is presented. To combine two polarizations into the same radiating aperture, an orthomode transducer (OMT) based upon a new double ridge waveguide cross section is developed. To provide greater flexibility in needed performance characteristics, several different turnstile junction matching sections are tested. A modular horn section is proposed to address flexible and ever changing operational requirements, and is designed for performance criteria such as constant gain, beamwidth, etc. A multi-section branch guide coupler and low loss Rotman lens based upon the proposed cross section are also developed. Prototyping methods for the herein designed millimeter wave electronic warfare front ends are investigated. Specifically, both printed circuit board (PCB) prototyping of micromachined systems and 3D printing of conventionally machined horns are presented. A 4--8 GHz two element array with

  4. Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: possible implications for the HI-6 antidote substrate specificity. (United States)

    Artursson, Elisabet; Andersson, Per Ola; Akfur, Christine; Linusson, Anna; Börjegren, Susanne; Ekström, Fredrik


    Nerve agents such as tabun, cyclosarin and Russian VX inhibit the essential enzyme acetylcholinesterase (AChE) by organophosphorylating the catalytic serine residue. Nucleophiles, such as oximes, are used as antidotes as they can reactivate and restore the function of the inhibited enzyme. The oxime HI-6 shows a notably low activity on tabun adducts but can effectively reactivate adducts of cyclosarin and Russian VX. To examine the structural basis for the pronounced substrate specificity of HI-6, we determined the binary crystal structures of Mus musculus AChE (mAChE) conjugated by cyclosarin and Russian VX and found a conformational mobility of the side chains of Phe338 and His447. The interaction between HI-6 and tabun-adducts of AChE were subsequently investigated using a combination of time resolved fluorescence spectroscopy and X-ray crystallography. Our findings show that HI-6 binds to tabun inhibited Homo sapiens AChE (hAChE) with an IC50 value of 300μM and suggest that the reactive nucleophilic moiety of HI-6 is excluded from the phosphorus atom of tabun. We propose that a conformational mobility of the side-chains of Phe338 and His447 is a common feature in nerve-agent adducts of AChE. We also suggest that the conformational mobility allow HI-6 to reactivate conjugates of cyclosarin and Russian VX while a reduced mobility in tabun conjugated AChE results in steric hindrance that prevents efficient reactivation.

  5. Guerilla Warfare & Law Enforcement: Combating the 21st Century Terrorist Cell within the U.S.

    Directory of Open Access Journals (Sweden)

    Major Richard Hughbank


    Full Text Available Both domestic and international terrorist organizations employ guerrilla warfare tactics, techniques, and procedures. Thus, the ability to identify and defeat the members of these organizations, cripple their infrastructures, and disrupt their financial resources lies in the understanding of modern guerrilla warfare as it develops in the twenty-first century within the United States.3 The forms of asymmetric warfare4 adopted by domestic and international terrorist groups alike is no longer intended to gain simple media exposure or governmental manipulation; they want to make an overpowering impact by causing massive loss of life and severe damage to infrastructure and are often motivated by religious imperatives and political goals. As terrorism analyst Stephen Flynn has observed, "Throughout the 20th century [Americans] were able to treat national security as essentially an out-of-body experience. When confronted by threats, [America] dealt with them on the turf of our allies or our adversaries. Aside from the occasional disaster and heinous crime, civilian life [in the United States] has been virtually terror-free." With the turn of the twenty-first century, terrorist operations have become more prevalent in the United States and are taking shape in the form of modern guerrilla warfare, thus creating new challenges for federal, state, and local law enforcement agencies. After reviewing the origin and nature of these challenges, this article will offer some suggestions for countering guerilla warfare in the United States.

  6. [Uricosuric agent]. (United States)

    Ohno, Iwao


    Urate lowering treatment is indicated in patients with recurrent acute attacks, tophi, gouty arthropathy, radiographic changes of gout, multiple joint involvement, or associated uric acid nephrolithiasis. Uricosuric agents like benzbromarone and probenecid are very useful to treat hyperuricemia as well as allopurinol (xanthine oxidase inhibitor). Uricosuric agents act the urate lowering effect through blocking the URAT1, an urate transporter, in brush border of renal proximal tubular cells. In order to avoid the nephrotoxicity and urolithiasis due to increasing of urinary urate excretion by using uricosuric agents, the proper urinary tract management (enough urine volume and correction of aciduria) should be performed.

  7. Research on performance of ethernet interface in network centric warfare

    Institute of Scientific and Technical Information of China (English)

    梁永生; 张乃通


    The concept of network centric warfare (NCW) and its character, high requirement of real-time synchronization are introduced. The distributed equal-node network architecture in NCW is presented. Based on theoretical analysis on ethernet interface performance, this paper presents that forwarding latency between ethernet interface devices is a key influence factor of real-time synchronization in NCW. Ethernet fundamental is briefly introduced. The model between a switch under test (SUT) and a smartbits card is presented and used for two interconnecting switches in NCW. On condition that ignoring the latency of connecting fiber or twisted pairs and processing latency of the smartbits test system, this paper presents that clock frequency tolerance (CFT) between a SUT and a smartbits card is a leading influence factor of forwarding latency of an ethernet switch. The formulae to calculate internal forwarding latency and forwarding latency caused by its CFT are deduced. Theoretical calculation on forwarding latency of an ethernet switch based on the given CFT and test time is implemented. Experimental study on primary forwarding latency and secondary forwarding latency is implemented and forwarding latency between the SUT and the smartbits card is measured, thus testifying the accuracy of the above theoretical analysis that the CFT is a key influence factor of forwarding latency. The measures to satisfy the needs of forwarding latency in NCW are presented.

  8. Drone Warfare: Twenty-First Century Empire and Communications

    Directory of Open Access Journals (Sweden)

    Kevin Howley


    Full Text Available This paper, part of a larger project that examines drones from a social-construction of technology perspective, considers drone warfare in light of Harold Innis’s seminal work on empire and communication. Leveraging leading-edge aeronautics with advanced optics, data processing, and networked communication, drones represent an archetypal “space-biased” technology. Indeed, by allowing remote operators and others to monitor, select, and strike targets from half a world away, and in real-time, these weapon systems epitomize the “pernicious neglect of time” Innis sought to identify and remedy in his later writing. With Innis’s time-space dialectic as a starting point, then, the paper considers drones in light of a longstanding paradox of American culture: the impulse to collapse the geographical distance between the United States and other parts of the globe, while simultaneously magnifying the cultural difference between Americans and other peoples and societies. In the midst of the worldwide proliferation of drones, this quintessentially sublime technology embodies this (disconnect in important, profound, and ominous ways.

  9. Back to the future: aerial warfare in Libya

    Directory of Open Access Journals (Sweden)

    João Paulo Nunes Vicente


    Full Text Available A century after the first air bomb mission, a new intervention in the same geographic space has made evident the changes in Airpower. The Aerial Warfare in Libya has radically changed the civil war, complying with a UN mission to protect Libyan population, imposing a no-fly zone and an arms embargo. Therefore, Operation Unified Protector became one of the most successful campaigns in the history of NATO. We aim to assess the operational efficiency of Airpower in the conflict in Libya, focusing on the challenges of a War essentially Aerial. Despite the military results and the fact that some political objectives were met, we can identify some concerning trends that, if not shifted, may negatively influence future NATO operations. We do not aim to draw general and universal conclusions on the strategic value of Airpower based on the analysis of a specific case. Above all, we focus on identifying some lessons which have influenced OUP operational efficiency. Thus, we must analyze some factors, such as the scope of objectives, the type of opposing action and aerial strategy used by the coalition and then focus on the challenges arising from the OUP.

  10. Vasoactive Agents


    Husedzinovic, Ino; Bradic, Nikola; Goranovic, Tanja


    This article is a short review of vasoactive drugs which are in use in todays clinical practice. In the past century, development of vasoactive drugs went through several phases. All of these drugs are today divided into several groups, depending on their place of action, pharmacological pathways and/or effects on target organ or organ system. Hence, many different agents are today in clinical practice, we have shown comparison between them. These agents provide new directions in the treatmen...

  11. Can biowarfare agents be defeated with light? (United States)

    Vatansever, Fatma; Ferraresi, Cleber; de Sousa, Marcelo Victor Pires; Yin, Rui; Rineh, Ardeshir; Sharma, Sulbha K; Hamblin, Michael R


    Biological warfare and bioterrorism is an unpleasant fact of 21st century life. Highly infectious and profoundly virulent diseases may be caused in combat personnel or in civilian populations by the appropriate dissemination of viruses, bacteria, spores, fungi, or toxins. Dissemination may be airborne, waterborne, or by contamination of food or surfaces. Countermeasures may be directed toward destroying or neutralizing the agents outside the body before infection has taken place, by destroying the agents once they have entered the body before the disease has fully developed, or by immunizing susceptible populations against the effects. A range of light-based technologies may have a role to play in biodefense countermeasures. Germicidal UV (UVC) is exceptionally active in destroying a wide range of viruses and microbial cells, and recent data suggests that UVC has high selectivity over host mammalian cells and tissues. Two UVA mediated approaches may also have roles to play; one where UVA is combined with titanium dioxide nanoparticles in a process called photocatalysis, and a second where UVA is combined with psoralens (PUVA) to produce “killed but metabolically active” microbial cells that may be particularly suitable for vaccines. Many microbial cells are surprisingly sensitive to blue light alone, and blue light can effectively destroy bacteria, fungi, and Bacillus spores and can treat wound infections. The combination of photosensitizing dyes such as porphyrins or phenothiaziniums and red light is called photodynamic therapy (PDT) or photoinactivation, and this approach cannot only kill bacteria, spores, and fungi, but also inactivate viruses and toxins. Many reports have highlighted the ability of PDT to treat infections and stimulate the host immune system. Finally pulsed (femtosecond) high power lasers have been used to inactivate pathogens with some degree of selectivity. We have pointed to some of the ways light-based technology may be used to defeat

  12. The Effect of Latency Reversal Agents on Primary CD8+ T Cells: Implications for Shock and Kill Strategies for Human Immunodeficiency Virus Eradication

    Directory of Open Access Journals (Sweden)

    Victoria E. Walker-Sperling


    Full Text Available Shock and kill strategies involving the use of small molecules to induce viral transcription in resting CD4+ T cells (shock followed by immune mediated clearance of the reactivated cells (kill, have been proposed as a method of eliminating latently infected CD4+ T cells. The combination of the histone deacetylase (HDAC inhibitor romidepsin and protein kinase C (PKC agonist bryostatin-1 is very effective at reversing latency in vitro. However, we found that primary HIV-1 specific CD8+ T cells were not able to eliminate autologous resting CD4+ T cells that had been reactivated with these drugs. We tested the hypothesis that the drugs affected primary CD8+ T cell function and found that both agents had inhibitory effects on the suppressive capacity of HIV-specific CD8+ T cells from patients who control viral replication without antiretroviral therapy (elite suppressors/controllers. The inhibitory effect was additive and multi-factorial in nature. These inhibitory effects were not seen with prostratin, another PKC agonist, either alone or in combination with JQ1, a bromodomain-containing protein 4 inhibitor. Our results suggest that because of their adverse effects on primary CD8+ T cells, some LRAs may cause immune-suppression and therefore should be used with caution in shock and kill strategies.

  13. CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies (United States)

    Gray, L R; Cowley, D; Welsh, C; Lu, H K; Brew, B J; Lewin, S R; Wesselingh, S L; Gorry, P R; Churchill, M J


    Latency-reversing agents (LRAs), including histone deacetylase inhibitors (HDACi), are being investigated as a strategy to eliminate latency in HIV-infected patients on suppressive antiretroviral therapy. The effectiveness of LRAs in activating latent infection in HIV strains derived from the central nervous system (CNS) is unknown. Here we show that CNS-derived HIV-1 strains possess polymorphisms within and surrounding the Sp transcription factor motifs in the long terminal repeat (LTR). These polymorphisms result in decreased ability of the transcription factor specificity protein 1 to bind CNS-derived LTRs, reducing the transcriptional activity of CNS-derived viruses. These mutations result in CNS-derived viruses being less responsive to activation by the HDACi panobinostat and romidepsin compared with lymphoid-derived viruses from the same subjects. Our findings suggest that HIV-1 strains residing in the CNS have unique transcriptional regulatory mechanisms, which impact the regulation of latency, the consideration of which is essential for the development of HIV-1 eradication strategies. PMID:26303660

  14. SiGe-based re-engineering of electronic warfare subsystems

    CERN Document Server

    Lambrechts, Wynand


    This book equips readers with a thorough understanding of the applicability of new-generation silicon-germanium (SiGe) electronic subsystems for the military purposes of electronic warfare and defensive countermeasures. The theoretical and technical background is extensively explained and all aspects of the integration of SiGe as an enabling technology for maritime, land, and airborne (including space) electronic warfare are addressed, including research, design, development, and implementation. The coverage is supported by mathematical derivations, informative illustrations, practical examples, and case studies. While SiGe technology provides speed, performance, and price advantages in many markets, sharing of information on its use in electronic warfare systems has to date been limited, especially in developing nations. This book will therefore be warmly welcomed as an engineering guideline that focuses especially on the speed and reliability of current-generation SiGe circuits and highlights emerging innov...


    Directory of Open Access Journals (Sweden)

    Sorin DUCARU


    Full Text Available The technological development and the instant communication possibilities advanced not only economic and social developments, but also evolving threats from those who exploit the vulnerabilities of communication and information systems. The cyber threat landscape points to a significant increase of the frequency, intensity, duration and sophistication of cyber-attacks. One of the new and concerning trends is the use of cyber capabilities in relation with military of hybrid operations – the so-called cyber dimension of hybrid warfare. NATO’s strategy on countering hybrid warfare is based on the triad: prepare-deter-defend, which also applies to cyber. Nations represent the first line of defence in countering hybrid strategies. International cooperation is also a key factor in this sense. It is in this context that NATO’s response to cyber-attacks in the context of hybrid warfare must be further refined.

  16. Fear as a medium of communication in asymmetric forms of warfare

    DEFF Research Database (Denmark)

    Harste, Gorm


    Fear is defined as the distinction between risk and danger, a distinction that operates in communicative forms. War is always also warfare about the form of war. The article describes how fear in warfare becomes a symbolically generalized medium of communication, mainly focusing on how the form...... of fear evolves in asymmetric warfare. Asymmetric war induces fear in both parties, but in a communicative form that leads to very different experiences of fear. Fear is observed and analysed with Niklas Luhmann’s theory of self-referential systems of communication and well as his theory of risk....... Following Luhmann and in continuation of Clausewitz’ conceptual tools, yet with other means, the article proposes to observe war as a system that can de-ontologize itself and thereby concern moving centres of gravity such as communication lines, motivation, public fear as well as perceptions of risk...

  17. The United States and biological warfare: secrets from the early cold war and Korea. (United States)

    Bruwer, A


    The United States and Biological Warfare is about accusations that the United States resorted to bacteriological warfare at a time of great military stress during the Korean War. In December 1951, the then US Secretary of Defense ordered early readiness for offensive use of biological weapons. Soon afterwards, the North Korean and Chinese armies accused the United States of starting a large-scale biological warfare experiment in Korea. The US State Department denied the accusation. Both parties to the dispute maintain their positions today. The authors spent 20 years researching the accusations in North America, Europe and Japan. They were the first foreigners to be given access to Chinese classified documents. The reader is also introduced to the concept of 'plausible denial', an official US policy which allowed responsible governmental representatives to deny knowledge of certain events. The authors hope that their work will contribute to the understanding of a time when modern war expanded into a new type of violence.

  18. Skeletal evidence for Inca warfare from the Cuzco region of Peru. (United States)

    Andrushko, Valerie A; Torres, Elva C


    This article addresses the bioarchaeological evidence for Inca warfare through an analysis of 454 adult skeletons from 11 sites in the Inca capital region of Cuzco, Peru. These 11 sites span almost 1000 years (AD 600-1532), which allows for a comparison of the evidence for warfare before the Inca came to power (Middle Horizon AD 600-1000), during the time of Inca ascendency in the Late Intermediate Period (AD 1000-1400), and after the Inca came to power and expanded throughout the Cuzco region and beyond (Inca Imperial Period, AD 1400-1532). The results indicate that 100 of 454 adults (22.0%) showed evidence of cranial trauma. Of these, 23 individuals had major cranial injuries suggestive of warfare, consisting of large, complete, and/or perimortem fractures. There was scant evidence for major injuries during the Middle Horizon (2.8%, 1/36) and Late Intermediate Period (2.5%, 5/199), suggesting that warfare was not prevalent in the Cuzco region before and during the Inca rise to power. Only in the Inca Imperial Period was there a significant rise in major injuries suggestive of warfare (7.8%, 17/219). Despite the significant increase in Inca times, the evidence for major cranial injuries was only sporadically distributed at Cuzco periphery sites and was entirely absent at Cuzco core sites. These findings suggest that while the Inca used warfare as a mechanism for expansion in the Cuzco region, it was only one part of a complex expansion strategy that included economic, political, and ideological means to gain and maintain control. Copyright © 2011 Wiley-Liss, Inc.

  19. [Inotropic agents]. (United States)

    Sasayama, Shigetake


    Depression of myocardial contractility plays an important role in the development of heart failure and many inotropic agents were developed to improve the contractile function of the failing heart. Agents that increase cyclic AMP, either by increasing its synthesis or reducing its degradation, exerted dramatic short-term hemodynamic benefits, but these acute effects were not extrapolated into long-term improvement of the clinical outcome of heart failure patients. Administration of these agents to an energy starved failing heart would be expected to increase myocardial energy use and could accelerate disease progression. The role of digitalis in the management of heart failure has been controversial, however, the recent large scale clinical trial has ironically proved that digoxin reduced the rate of hospitalization both overall and for worsening heart failure. More recently, attention was paid to other inotropic agents that have a complex and diversified mechanism. These agents have some phosphodiesterase-inhibitory action but also possess additional effects, including cytokine inhibitors, immunomodulators, or calcium sensitizers. In the Western Societies these agents were again shown to increase mortality of patients with severe heart failure in a dose dependent manner with the long-term administration. However, it may not be the case in the Japanese population in whom mortality is relatively low. Chronic treatment with inotropic agent may be justified in Japanese, as it allows optimal care in the context of relief of symptoms and an improved quality of life. Therefore, each racial group should obtain specific evidence aimed at developing its own guidelines for therapy rather than translating major guidelines developed for other populations.

  20. EMPA-REG and Other Cardiovascular Outcome Trials of Glucose-lowering Agents: Implications for Future Treatment Strategies in Type 2 Diabetes Mellitus. (United States)

    Schernthaner, Guntram; Schernthaner-Reiter, Marie Helene; Schernthaner, Gerit-Holger


    During the last decade, the armamentarium for glucose-lowering drugs has increased enormously by the development of DPP-4 inhibitors, GLP-1 receptor agonists and SGLT2 inhibitors, allowing individualization of antidiabetic therapy for patients with type 2 diabetes (T2DM). Some combinations can now be used without an increased risk for severe hypoglycemia and weight gain. Following a request of the US Food and Drug Administration, many large cardiovascular (CV) outcome studies have been performed in patients with longstanding disease and established CV disease. In the majority of CV outcome studies, CV risk factors were well controlled and a high number of patients were already treated with ACE inhibitors/angiotensin receptor blockers, statins and antiplatelet drugs. Most studies with insulin glargine and newer glucose-lowering drugs (saxagliptin, alogliptin, sitagliptin, lixisenatide) demonstrated safety of newer glucose-lowering agents but did not show superiority in the CV outcomes compared with placebo. By contrast, in the EMPA-REG OUTCOME (Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients) study, CV death, all-cause mortality, and hospitalization for heart failure were significantly decreased when empagliflozin was added instead of placebo to therapy for patients with high CV risk and T2DM already well treated with statins, glucose-lowering drugs, and blood pressure-lowering drugs as well as antiplatelet agents. In addition, renal endpoints including endstage renal disease were also significantly reduced when empagliflozin was added instead of placebo. Interestingly, the reduction of these clinically relevant end points was observed after a few months, making antiatherogenic effects an unlikely cause. The fact that the incidence of myocardial infarction (MI) and stroke were not reduced is in line with the hypothesis that hemodynamic factors in particular have contributed to the impressive improvement of the prognosis. To

  1. New strategies for the treatment of hepatitis C virus infection and implications of resistance to new direct-acting antiviral agents

    Directory of Open Access Journals (Sweden)

    Josep Quer


    Full Text Available Josep Quer1–3, Maria Buti1–3, Maria Cubero1–3, Jaume Guardia1–3, Rafael Esteban1–3, Juan Ignacio Esteban1–31Liver Unit, Internal Medicine Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR, Barcelona, Spain; 2Universitat Autònoma de Barcelona, Barcelona, Spain; 3Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd, Instituto de Salud Carlos III, Madrid, SpainAbstract: Persistent hepatitis C virus (HCV infection is a leading cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma and the major indication for liver transplantation in adults. Current standard of care treatment (SOC with pegylated-interferon-a 2 and ribavirin (RBV has a limited efficacy and is associated with significant side effects frequently associated with poor compliance or treatment discontinuation, requiring specialized and frequent monitoring. To overcome the limited efficacy of SOC, more than 50 direct-acting antiviral agents (DAA designed to target viral-encoded proteins essential in the HCV life cycle are currently under development. The rapid selection of resistant mutants associated with the quasispecies nature of HCV with high mutation and replication rates is one of the main challenges for the new HCV therapies. Predictive host and viral factors together with combination of DAAs with or without IFN and/or RBV need to be accurately evaluated to design the most effective individualized treatment strategy within the shortest time interval and with minimum side effects.Keywords: HCV, treatment, quasispecies, resistance

  2. Sunscreening Agents (United States)

    Martis, Jacintha; Shobha, V; Sham Shinde, Rutuja; Bangera, Sudhakar; Krishnankutty, Binny; Bellary, Shantala; Varughese, Sunoj; Rao, Prabhakar; Naveen Kumar, B.R.


    The increasing incidence of skin cancers and photodamaging effects caused by ultraviolet radiation has increased the use of sunscreening agents, which have shown beneficial effects in reducing the symptoms and reoccurrence of these problems. Many sunscreen compounds are in use, but their safety and efficacy are still in question. Efficacy is measured through indices, such as sun protection factor, persistent pigment darkening protection factor, and COLIPA guidelines. The United States Food and Drug Administration and European Union have incorporated changes in their guidelines to help consumers select products based on their sun protection factor and protection against ultraviolet radiation, whereas the Indian regulatory agency has not yet issued any special guidance on sunscreening agents, as they are classified under cosmetics. In this article, the authors discuss the pharmacological actions of sunscreening agents as well as the available formulations, their benefits, possible health hazards, safety, challenges, and proper application technique. New technologies and scope for the development of sunscreening agents are also discussed as well as the role of the physician in patient education about the use of these agents. PMID:23320122

  3. Mobile Agents (United States)

    Satoh, Ichiro

    Mobile agents are autonomous programs that can travel from computer to computer in a network, at times and to places of their own choosing. The state of the running program is saved, by being transmitted to the destination. The program is resumed at the destination continuing its processing with the saved state. They can provide a convenient, efficient, and robust framework for implementing distributed applications and smart environments for several reasons, including improvements to the latency and bandwidth of client-server applications and reducing vulnerability to network disconnection. In fact, mobile agents have several advantages in the development of various services in smart environments in addition to distributed applications.

  4. A Concept of a Probable Autoinjector for Bio-threat Agents

    Directory of Open Access Journals (Sweden)

    R.V. Geetha


    Full Text Available Chemical and biological weapons can be used during conflicts and by terrorists to injure or kill humans and animals. Chemical weapons contain toxic chemicals and biological weapons contain pathogenic organisms. With proper protective equipments and training, the lethal effects of chemical and biological warfare agents can be minimised. First aid kit is available that contain detection, decontamination and medical protection for chemical warfare agents including autoinjectors, for rapid administration and faster absorption of drugs. The autoinjectors are safe and available for life saving drugs like atropine sulphate and pralidoxime chloride (nerve agent poisoning, epinephrine (anaphylaxis, diazepam (seizures and sumatriptan (migraine. For bio-threat agents doxycycline alone is available as a broad spectrum antibiotic in the first aid kit. Majority of the bacterial agents are gram negative and hence amikacin drug cartridge was developed for the existing autoinjector. The advantage of amikacin is its safety, stability, can be given prophylactically and supplemented with other antibiotics when medical attention arrives. The usability and tolerability of amikacin administered repeatedly through autoinjector was studied using various haematological, biochemical and oxidative stress parameters in animal models. The results are promising and as there is no antibiotic autoinjector available, amikacin autoinjector can be considered for bio-threat agents.

  5. SEM: A Cultural Change Agent (United States)

    Barnes, Bradley; Bourke, Brian


    The authors advance the concept that institutional culture is a purposeful framework by which to view SEM's utility, particularly as a cultural change agent. Through the connection of seemingly independent functions of performance and behavior, implications emerge that deepen the understanding of the influence of culture on performance outcomes…

  6. Antibiotic Agents (United States)

    ... agents. A recent survey reported that 76% of liquid soaps from 10 states in the US contained triclosan ... regulated depends upon its intended use and its effectiveness. The US Food and Drug Administration (FDA) regulates antibacterial soaps and antibacterial substances that will either be used ...

  7. A statistical analysis of the effect of warfare on the human secondary sex ratio

    NARCIS (Netherlands)

    Graffelman, J.; Hoekstra, R.F.


    Many factors have been hypothesized to affect the human secondary sex ratio (the annual percentage of males among all live births), among them race, parental ages, and birth order. Some authors have even proposed warfare as a factor influencing live birth sex ratios. The hypothesis that during and s

  8. Sandals and Robes to Business Suits and Gulf Streams: Warfare in the 21st Century (United States)


    cartels, or simply shooting an American for the price of a loaf of bread to feed their families, we need to better understand what we’re facing. From...our goals, but as warfare becomes more untenable in the age of social media, as the unacceptable killing of civilians on any battlefield could lose

  9. (Review of) Reno, William. 2011. Warfare in Independent Africa. Cambridge: Cambridge University Press

    DEFF Research Database (Denmark)

    Hagmann, Tobias


    Warfare in Independent Africa is Reno’s bold attempt to analyze the modern history of African insurgencies. The book tackles this task through the prism of five generations of rebel, which left their mark on the continent; anti-colonial rebels, majority rule rebels, reform rebels, warlord rebels ...


    Directory of Open Access Journals (Sweden)

    Nane Zeynalyan


    Full Text Available In the recent decades, war fields have moved into the information sphere. Today’s person has reason to “be informed”; as having information provides a sense of security. In the modern world, great effort is invested in expanding information sources, because it serves to articulate both international policies and the context of wars. The exchange of information in domestic and international platforms influences the quality of public debate and ideology, which affects social attitudes and decision-making processes. This article presents the role of information-psychological warfare as a factor in forming public opinion. It discusses the peculiarities of organizing an information-psychological warfare during military conflicts. The goal of our research is to explore how social groups might perceive peculiarities in the information-psychological warfare. The research involves methods of survey, content analysis, and free associations. The effectiveness of psychological warfare significantly depends on how people perceive information. Consequently, in the contemporary world, it is necessary to not only protect or fight on the battlefield, but also to use information weapons. This imposes requirements on psychological scientists to explore peculiarities around the perception of information to help find mechanisms that safeguard people’s lives by way of contributing to the formation of necessary attitudes and stereotypes.

  11. Detachment 101 in the CBI: An Unconventional Warfare Paradigm for Contemporary Special Operations (United States)


    American Espionage. NY: Reynal and Hitchcock , 1946. Barrett, Neil H. Chingpaw. NY: Vantage, 1962. Bartholomew-Feis, Dixee R. The O.S.S. and Ho Chi...United States Army. Washington, D.C.: U.S. Government Printing Office, 1990. Paddock, Alfred H. U.S. Army Special Warfare; Its Origins. Lawrence, KS

  12. Application of non-quantitative modelling in the analysis of a network warfare environment

    CSIR Research Space (South Africa)

    Veerasamy, N


    Full Text Available of the various interacting components, a model to better understand the complexity in a network warfare environment would be beneficial. Non-quantitative modelling is a useful method to better characterize the field due to the rich ideas that can be generated...

  13. From Douhet to drones, air warfare, and the evolution of targeting

    NARCIS (Netherlands)

    Osinga, F.P.B.; Roorda, M.P.; Ducheine, P.A.L.; Schmitt, M.N.; Osinga, F.P.B.


    Through the prism of the experience of air warfare, this chapter identifies key factors that have shaped targeting. These include technological developments, organizational structures, and processes and inter-service competition for scarce resources. Moreover, targeting is informed by perspectives o

  14. Evaluating Effectiveness of a Frigate in an Anti-Air Warfare (AAW) Environment (United States)


    air warfare (AAW), weapon selection, unmanned aerial vehicle, simulation, design of experiments, combat systems 15. NUMBER OF PAGES 81 16. PRICE ...Explanation of a Cookie-Cutter Sensor. ........................ 19 Figure 12. Stop Conditions Menu in MANA...companies sell these deadly missiles at affordable prices to allow many countries to easily employ them onboard their warships. Missiles also offer

  15. Military medicine and the ethics of war: British colonial warfare during the Seven Years War (1756-63). (United States)

    Charters, Erica


    This article examines 18th-century European warfare, tracing the first formal codifications of conventions of war, frequently introduced by military physicians and initially regarding the treatment of the sick and wounded. It outlines to what extent these conventions were followed in practice, particularly in the challenging environment of American irregular warfare, with a focus on the most well-known incident of "biological warfare" in the period: the deliberate spread of smallpox by British officers among Amerindians in 1763. More broadly, it demonstrates that the history of military medicine provides a fruitful method with which to uncover assumptions about the ethics of war.

  16. Molecular dynamics of the interaction of pralidoxime and deazapralidoxime with acetylcholinesterase inhibited by the neurotoxic agent tabun


    Gonçalves,Arlan da S.; França,Tanos C. C.; Wilter,Alan; Figueroa-Villar,José D.


    Efficient acetylcholinesterase reactivators are fundamental for the development of antidotes against poisoning by neurotoxic pesticides and chemical warfare agents. However, the mechanism of the reactivation reaction and the structural characteristics of the known reactivators are poorly understood. In order to study the dynamic behavior and the effect of the antidote net charge in the reactivation of this enzyme, we carried out a molecular dynamics study of human acetylcholinesterase inhibit...

  17. Radioprotective Agents (United States)


    claimed to be effective are gallic acid derivatives, eg, sodium gallate 12053-21-61 (295-297) and propyl gallate 1121-79-91 (298). p...inhibition of a-adrenergic receptors can be achieved through the use of the antiradiation agents 2-(5-aminopentylamino)ethanephos- phorothioic acid ...tissue was ap- preciated immediately as a potential medical set, and they were put to use en- thusiastically. Early workers did notice an erythematous

  18. The 2006 Lebanon Campaign and the Future of Warfare: Implications for Army and Defense Policy (United States)


    Colombia have demonstrated the willingness and capability to resist combined ground-air attacks from government forces (David Spencer, “ Bogota ...primarily directed at the Dahyia, the Beqaa Valley near the Syrian border, and the region south of the Litani River . (See Figure 2.)43 Credit...campaign, Operation CHANGE OF DIRECTION 11.50 Described as a “push to the Litani,” the main effort was actually a westward advance parallel to the river

  19. The Changing Nature of Warfare, the Factors Mediating Future Conflict, and Implications for SOF (United States)


    to the US influence over global finance is the rapid emergence of China’s economy and the outrageous balance of trade deficit that we have...the uber -politically correct notion of domestic violence. In the post-OJ environment, law en- forcement agencies are hypersensitive to potential...relationships, which are sometimes fragile, as our vulnerabilities. In reality, most sophisticated economies are based on public trust and

  20. Russia’s Ambiguous Warfare and Implications for the U.S. Marine Corps (United States)


    broadcast in Russia on March 15, 2015 (on the first anniversary of Crimea’s disputed independence referendum), Russian president Vladimir Putin boasted that...The revised Russian Military Doctrine signed by President Vladimir Putin in December 2014 identifies NATO and NATO enlargement as a mitigating Turkish concerns. Vladimir Putin recently announced that he would abandon the plan to build the South Stream pipeline for Russian gas

  1. Steeling the Mind. Combat Stress Reactions and Their Implications for Urban Warfare (United States)


    appearance. The "soldier’s heart" and "nostal- gia" of the Civil War graduated to the "shell shock" of World War I. The British Army struggled to stem the...vomiting, or diarrhea Physical exhaustion Fatigue Freezes or is immobile under fire "Thousand yard" stare Staggers or sways Difficulty thinking, speaking ...Argumentative, acts recklessly Forgetfulness, inability to Indifferent to danger concentrate Memory loss Nightmares Stutters severely, mumbles, or Easily

  2. The Israeli Approach to Irregular Warfare and Implications for the United States (United States)


    tabula - rasa strategy later resulted in recriminations and reevaluation. In Tall Afar and Ramadi, U.S. forces implemented tactics to secure and gain...Sayeret Golani, and possi- bly Sayeret Mat’Kal.17 Israeli special units played a large role in a highly successful counterinsurgency campaign along...transmissions. The Aman plays a predominate role in setting missions of small special forces. A tendency within the Israeli SOF community that has been less

  3. The Implications of Network-Centric Warfare for United States and Multinational Military Operations (United States)


    31. Rear Admiral D. Mayo, Bandwidth Baseline Assesment Memo, <>, p. 22. 14... smoke signals or drums, or carefully selected commercial technology? The United States experience in Somalia and the Russian experience in

  4. Airpower and the Environment: The Ecological Implications of Modern Air Warfare (United States)


    Joel Hayward’s chapter 11 in this volume for a dierent perspective on DU.] 13. Frumkin, Hess , and Vindigni, “Energy and Public Health”; and Klare...of armaments production. Reichsmarschall Herman Göring commanded the Luwae. 19. Webster and Frankland, Strategic Air Oensive against Germany, vol...Howard, Jeremy Hess , and Stephen Vindigni. “Energy and Public Health: e Challenge of Peak Petroleum.” Public Health Reports 124, no. 1 (January–February

  5. Evidence of VX nerve agent use from contaminated white mustard plants. (United States)

    Gravett, Matthew R; Hopkins, Farrha B; Self, Adam J; Webb, Andrew J; Timperley, Christopher M; Baker, Matthew J


    The Chemical Weapons Convention prohibits the development, production, acquisition, stockpiling, retention, transfer or use of chemical weapons by Member States. Verification of compliance and investigations into allegations of use require accurate detection of chemical warfare agents (CWAs) and their degradation products. Detection of CWAs such as organophosphorus nerve agents in the environment relies mainly upon the analysis of soil. We now present a method for the detection of the nerve agent VX and its hydrolysis products by gas chromatography and liquid chromatography mass spectrometry of ethanol extracts of contaminated white mustard plants (Sinapis alba) which retained the compounds of interest for up to 45 days. VX is hydrolysed by the plants to ethyl methylphosphonic acid and then to methylphosphonic acid. The utility of white mustard as a nerve agent detector and remediator of nerve agent-polluted sites is discussed. The work described will help deter the employment of VX in conflict.

  6. Irregular Warfare and Future War: Strategy and Defense Planning; Strategic Insights, v. 10, Special issue (October 2011), 92-98. Topic: Global Trends and Future Warfare ; Part II: Technological and Doctrinal Innovation


    Russell, James A.


    This article appeared in Strategic Insights, v.10, Special issue (October 2011), 92-98. Topic: Global Trends and Future Warfare ; Part II: Technological and Doctrinal Innovation Approved for public display, distribution unlimited The purpose of this paper is threefold: to speculate on the role and prominence of irregular warfare in the strategic environment over the next quarter century, to comment on the impact that phenomenon may have on shaping the postulated scenarios addressed in t...

  7. Disinfection of biological agents in the field using a mobile ... (United States)

    Report The Army’s Net Zero Initiative is an energy-conservation program that focuses on energy as well as water and waste usage procedures. All Net Zero projects are geared toward helping the military installation or community become more sustainable and resilient, with an emphasis on taking a systems approach. Net Zero projects must advance the state of the science and are focused on three general topic areas: water, energy, and waste, and the nexuses among them. This project examined the inactivation and/or removal of biological contaminants in dirty wash water using a portable ozone-UV AOP process. The strain of E. coli used in these experiments is not a biological warfare agent, but acts as a surrogate for certain of the vegetative biological agents such as the enterohemorrhagic strain designated E. coli 0157:H7.

  8. Functionalized polymer nanofibre membranes for protection from chemical warfare stimulants

    Energy Technology Data Exchange (ETDEWEB)

    Ramaseshan, Ramakrishnan [Nanoscience and Nanotechnology Initiative, National University of Singapore, 2 Engineering Drive 3, Singapore 117576, Singapore (Singapore); Sundarrajan, Subramanian [Nanoscience and Nanotechnology Initiative, National University of Singapore, 2 Engineering Drive 3, Singapore 117576, Singapore (Singapore); Liu, Yingjun [Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore (Singapore); Barhate, R S [Nanoscience and Nanotechnology Initiative, National University of Singapore, 2 Engineering Drive 3, Singapore 117576, Singapore (Singapore); Lala, Neeta L [Nanoscience and Nanotechnology Initiative, National University of Singapore, 2 Engineering Drive 3, Singapore 117576, Singapore (Singapore); Ramakrishna, S [Nanoscience and Nanotechnology Initiative, National University of Singapore, 2 Engineering Drive 3, Singapore 117576, Singapore (Singapore)


    A catalyst for the detoxification of nerve agents is synthesized from {beta}-cyclodextrin ({beta}-CD) and o-iodosobenzoic acid (IBA). Functionalized polymer nanofibre membranes from PVC polymer are fabricated with {beta}-CD, IBA, a blend of {beta}-CD+IBA, and the synthesized catalyst. These functionalized nanofibres are then tested for the decontamination of paraoxon, a nerve agent stimulant, and it is observed that the stimulant gets hydrolysed. The kinetics of hydrolysis is investigated using UV spectroscopy. The rates of hydrolysis for different organophosphate hydrolyzing agents are compared. The reactivity and amount of adsorption of these catalysts are of higher capacity than the conventionally used activated charcoal. A new design for protective wear is proposed based on the functionalized nanofibre membrane.

  9. Trading Agents

    CERN Document Server

    Wellman, Michael


    Automated trading in electronic markets is one of the most common and consequential applications of autonomous software agents. Design of effective trading strategies requires thorough understanding of how market mechanisms operate, and appreciation of strategic issues that commonly manifest in trading scenarios. Drawing on research in auction theory and artificial intelligence, this book presents core principles of strategic reasoning that apply to market situations. The author illustrates trading strategy choices through examples of concrete market environments, such as eBay, as well as abst

  10. The Short-Term Effect of Chest Physiotherapy on Spirometric Indices in Chemical Warfare Victims Exposed to Mustard Gas


    Abedi, A.; HR Koohestani; Z Roosta


    ABCTRACT Introduction & Objective: Chronic respiratory diseases are the most prevalent late sequels of sulfur mustard gas injury among Iranian chemical warfare victims. Chest physiotherapy is one of the useful methods in care, cure and infection prevention of these patients. The aim of this study was to determine the short-term effect of chest physiotherapy on spirometric indices in chemical warfare victims exposed to sulfur mustard gas. Materials & Methods: In this study, 27 of the chemical ...

  11. Agent-based modeling and simulation Part 3 : desktop ABMS.

    Energy Technology Data Exchange (ETDEWEB)

    Macal, C. M.; North, M. J.; Decision and Information Sciences


    Agent-based modeling and simulation (ABMS) is a new approach to modeling systems comprised of autonomous, interacting agents. ABMS promises to have far-reaching effects on the way that businesses use computers to support decision-making and researchers use electronic laboratories to support their research. Some have gone so far as to contend that ABMS 'is a third way of doing science,' in addition to traditional deductive and inductive reasoning (Axelrod 1997b). Computational advances have made possible a growing number of agent-based models across a variety of application domains. Applications range from modeling agent behavior in the stock market, supply chains, and consumer markets, to predicting the spread of epidemics, the threat of bio-warfare, and the factors responsible for the fall of ancient civilizations. This tutorial describes the theoretical and practical foundations of ABMS, identifies toolkits and methods for developing agent models, and illustrates the development of a simple agent-based model of shopper behavior using spreadsheets.

  12. Brucella as a potential agent of bioterrorism. (United States)

    Doganay, Gizem D; Doganay, Mehmet


    Perception on bioterrorism has changed after the deliberate release of anthrax by the postal system in the United States of America in 2001. Potential bioterrorism agents have been reclassified based on their dissemination, expected rate of mortality, availability, stability, and ability to lead a public panic. Brucella species can be easily cultured from infected animals and human materials. Also, it can be transferred, stored and disseminated easily. An intentional contamination of food with Brucella species could pose a threat with low mortality rate. Brucella spp. is highly infectious through aerosol route, making it an attractive pathogen to be used as a potential agent for biological warfare purposes. Recently, many studies have been concentrated on appropriate sampling of Brucella spp. from environment including finding ways for its early detection and development of new decontamination procedures such as new drugs and vaccines. There are many ongoing vaccine development studies; some of which recently received patents for detection and therapy of Brucella spp. However, there is still no available vaccine for humans. In this paper, recent developments and recent patents on brucellosis are reviewed and discussed.

  13. Strategies for the prevention of a successful biological warfare aerosol attack. (United States)

    Wiener, S L


    Biological warfare (BW) aerosol attacks are different from chemical attacks in that they may provide no warning/all clear signals that allow the soldier to put on or remove his M17/M40 protective mask. Methods are now being perfected to detect a BW aerosol cloud using an airborne (helicopter) pulsed laser system to scan the lower altitudes upwind from a troop concentration of corps size, and to sample and analyze the nature of the aerosol within a brief time interval. This system has certain limitations and vulnerabilities, since it is designed specifically to detect a line-type aerosol attack. Provision of, training with, and field use of a lightweight dust mist or HEPA filter respirator for each soldier is proposed for protection against undetected aerosol attacks. This particulate filter respirator would be issued in addition to the M17/M40 mask. Such a BW respirator will be able to purify the soldier's air by removing particles in the 0.3- to 15-micro m-diameter range with an efficiency of 98 to 100%. Particle size of BW aerosols is in the same range, with an optimum size for high-efficiency casualty production of 1 to 5 micro m mass median diameter. The proposed BW respirator will be lightweight; will require low inhalation pressures; will be comfortable to wear for prolonged periods; will not interfere with vision, hearing, and communication; and will not degrade overall effectiveness and performance to the degree observed with the M17/M40 masks. Such respirators would be worn as part of a contingency defense against an enemy likely to use BW agents. This respirator could be worn for prolonged periods when under threat of an undetectable BW attack during weather conditions favorable to the success of such an attack (i.e., low wind velocity and temperature inversion in the target area). In addition, tactically important assets such as command and control centers and missile batteries can also be protected continuously by air filtration systems powered by

  14. The Military-Entertainment Complex: A New Facet of Information Warfare

    Directory of Open Access Journals (Sweden)

    Adam Muir


    Full Text Available The second Gulf War will become synonymous with the emergence of fully-fledged information warfare where the military-entertainment complex has so influenced strategic and logistic possibilities that it becomes apparent that the war was waged as entertainment. This is entertainment not as an amusement or diversion but utilising the techniques and tropes of the burgeoning entertainment industry as a means to achieve military objectives. This paper offers a short history of the military-entertainment complex as reality and simulation become fused in the practices of the US military machine. The paper then briefly explores three central aspects of this phenomenon evident in recent developments: the military function of computer games; the role of the Hollywood scenario and the blurring between news and reality TV. Finally the suggestion is made that subverting, co-opting and reconstructing the military-entertainment complex provides new possibilities for alternative strategies of information warfare.

  15. New studies disputing allegations of bacteriological warfare during the Korean War. (United States)

    Rolicka, M


    In the television series Korea the Unknown War produced jointly by Thames Television (London) and WGBH (Boston) in 1990, General Matthew Ridgway, Commander in Chief of United Nations forces during the Korean War, called the accusations that the United States waged bacteriological warfare "black propaganda." The charges discredited the United States and, despite denials and many international discussions, have not been completely refuted until new. Following studies in archives previously not available for research and after uncovering new sources, many specific examples of black propaganda were discovered that contained false information and lies discrediting the United States. The mechanism of lies, which convinced the Korean population that bacteriological warfare was going on and that the only way not to become victims of the United States' inhuman cruelty was to fight, are shown in this paper.

  16. Integrated electronic warfare framework for infrared self-protection of transport aircraft

    CSIR Research Space (South Africa)

    Annamalai, L


    Full Text Available Warfare Framework for Infrared Self-protection of Transport Aircraft L. Annamalai Council for Scientific and Industrial Research (CSIR) Abstract - In the African scenario, slow-moving airborne platforms such as transport aircraft have in recent... predetermined baseline were considered the best method of optimising aircraft operating procedures against threats. L. Annamalai, Defence Peace, Safety and Security (DPSS), Council for Scientific and Industrial Research (CSIR), PO Box 395, 0001...

  17. Aerospace Power in Urban Warfare: Beware the Hornet’s Nest (United States)


    Board Task Force on Military Operations in Built-Up Areas ( MOBA )," (Washington, DC: Office of the Undersecretary of Defense for Acquisition and...Smithsonian Institute Press, 1999), 130. 45 Vick, et al., 120. 46 Rebecca A. Grant, "The Radar Game ," Air Force Magazine, February 1999, 52-60. Grant...University Press, 1962. Grant, Rebecca A. "The Radar Game ." Air Force Magazine, February 1999, 52-60. Hawkins, William R. Putting Urban Warfare in

  18. Diagnosing Guerilla Warfare: Was William Clarke Quantrill Missouri’s Francis Marion? (United States)


    frightful epoch when priests, women, and children throughout Spain plotted the murder of isolated soldiers." -Antoine-Henri J omini Jomini2...there are setbacks at any stage there sequences can be reversed to a previous phase.29 FRANCIS MARION AND GUERILLA WARFARE One of the most famous...Militia under General 28 D.M. Frost to stage his forces near the St. Louis Arsenal, as a "training camp," at what became known as Camp Jackson. 148

  19. Management of DoD Irregular Warfare (IW) and Security Force Assistance (SFA) Capabilities (United States)


    manage DoD personnel with skills , training, education, and experience related to IW and SFA. DoDI 3000.11, May 3, 2016 TABLE OF CONTENTS 2...DOD INSTRUCTION 3000.11 MANAGEMENT OF DOD IRREGULAR WARFARE (IW) AND SECURITY FORCE ASSISTANCE (SFA) CAPABILITIES Originating Component...well as building the security capacity and capability of U.S. partners and allies. c. IW and SFA skills , training, education, and experience must be

  20. A Survey of Game Theoretic Approaches to Modelling Decision-Making in Information Warfare Scenarios


    Kathryn Merrick; Medria Hardhienata; Kamran Shafi; Jiankun Hu


    Our increasing dependence on information technologies and autonomous systems has escalated international concern for information- and cyber-security in the face of politically, socially and religiously motivated cyber-attacks. Information warfare tactics that interfere with the flow of information can challenge the survival of individuals and groups. It is increasingly important that both humans and machines can make decisions that ensure the trustworthiness of information, communication and ...

  1. Investigating Iraq’s Chemical Warfare Program: Updated and Expanded Research Plan (United States)


    chemical warfare, chemical weapons, Conflict Records Research Center, Tabun , Sarin, UN Sepcial Commission, UN UN Monitoring, Verification and Inspection...7 for tabun and sarin; and Ahmed 2 & 3 for production of precursors for tabun and sarin. The general contractor is Al Fao General Establishment that... tabun , and sarin. “mid- 1970s” Al Hazen Institute has by this time set up contacts with “30 major foreign organizations and companies” for securing

  2. Coalition Warfare Program Tactile Situation Awareness System for Aviation Applications: Simulator Flight Test (United States)


    USAARL Report No. 2016-07 Coalition Warfare Program Tactile Situation Awareness System for Aviation Applications: Simulator Flight Test By...pilot evaluation of The Tactile Situation Awareness System (TSAS) during simulated flight . The objective was to evaluate the ability of TSAS to improve...summarizes recent findings obtained during a simulated helicopter flight employing TSAS. The objective was to evaluate the ability of TSAS to improve a

  3. Landmine Warfare in Support of Multi-domain Battle: Balancing Discrimination and Military Effectiveness (United States)


    military personnel, obstruct economic development and reconstruction following a conflict, inhibit the repatriation of refugees and internally displaced...Basing themselves on the principle of international law that the right of the parties to an armed conflict to choose methods or means of warfare is...Conflict in the Gulf (London: Atlantic Books, 2006), 120-21. 30 Human Rights Watch, “Back in Business? US Landmine Production and Exports,” briefing

  4. Special Operations, Irregular Warfare, and Operational Art: A Theory of Special Operations (United States)


    D.C.: U.S. Army Center of Military History, 2002), 304–308. 66Walter Laqueur , Guerrilla Warfare: A Historical & Critical Study (New Brunswick, NJ...Strategy in Guerrilla War Against Japan, 15–16. 72Peter L. Berger and Thomas Luckmann, The Social Construction of Reality (New York: Anchor Books...each other, undermining each other’s positions, or making a separate peace. The Some authors, such as Thomas Hammes, have argued that the

  5. Guerrilla Operations in the Civil War: Assessing Compound Warfare During Price’s Raid (United States)


    hand, Three Years with Quantrill by O. S. Barton and Noted Guerrillas, or the Warfare on the Border by John Edwards provide alternate views described in other sources. For example, Barton relates John McCorkle’s account of the story about guerrillas who Price’s army before the Battle of...Jay Monaghan provided excellent accounts of the major operations in the Trans-Mississippi Department during the Civil War. Finally, the framework for

  6. China’s Development of Asymmetric Warfare and the Security of Taiwan, Republic of China (United States)


    thanks to my loving and devoted wife, Anita . Her patience, understanding, and remarkable ability to maintain a pleasant, comforting home during this...should arise (Bolt, Brenner , 2004, p.130). Information warfare technology can delay a United States response and commitment in the Taiwan Strait in...destruction of C4 systems by missiles, airpower, and high-energy weapons (Bolt & Brenner , 2004, p.133). Perhaps the most astonishing view of the PRC’s IW

  7. Pirates of the Nuclear Age: The Role of U.S. Submarines in Modern Trade Warfare (United States)


    the Department of the Navy. Signature: _____________________ 14 July 2016 ii Contents Page...World War II ,” (U.S. Navy, Office of the Chief of Naval Operations, Submarine Warfare Division, 1999). 2 Geoffrey Till, “A Changing Focus for the...escalation to nuclear war or a major conventional war such as the forcible reunification of Taiwan via a cross-strait invasion. If U.S. national strategic

  8. Challenges in Coalition Unconventional Warfare: The Allied Campaign in Yugoslavia, 1941-1945 (United States)


    JFQ 75, 4th Quarter 2014 Duke, Phil lips, and Conover 129 Challenges in Coalition Unconventional Warfare The Allied Campaign in Yugoslavia , 1941...resistance elements in Yugoslavia . The resistance movement effectively fixed in place 35 German and Italian divisions, consisting of roughly 660,000...mountain headquarters in Yugoslavia on May 14, 1944 (Imperial War Museum) Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting

  9. Hungary’s alternative to counter hybrid warfare small state’s weaponized citizenry. (United States)


    Wales and Warsaw emphasized the importance of cyber defense as a crucial capability of the international security environment against hybrid threats ...and “raising public awareness on cyber threats and cyber security .”214 In other words, the Cyber Defence Unit promotes the connection between the...from asymmetric threats , and has to cover all domains–including cyber . Former studies on countering hybrid warfare have identified these

  10. A Need for Systems Architecture Approach for Next Generation Mine Warfare Capability (United States)


    uncontrolled mining ultimately led to the first Hague convention where 10 Henry Petroski (1992). To Engineer is...Littoral and Mine Warfare, without which I would not have been able to participate in this program. Jon, Henry and Capt. “J” juggling between work, home...Palmer, M. (1992). Guardians of the Gulf. [Photograph], Free Press, New York. Petroski , H (1992). To Engineer is Human: The Role of Failure in

  11. Courses of Action for Enhancing USAF ’Irregular Warfare’ Capabilities: A Functional Solutions Analysis (United States)


    Warfare Center to ensure that technological opportunities for novel IW appli- cations were explored, developed, and fielded. (See pp. 38–40...activities; transnational criminal activities, including narco -trafficking, illicit arms dealing, and illegal financial transactions, that support or...opportunities for novel IW applications are explored, devel- oped, and fielded. In fact, over time, it might be appropriate for the USAF to create a

  12. No Compromise: Establishing Balance in the US Army’s Approach to Full-Spectrum Warfare (United States)


    also needlessly prolongs corporate acceptance for a leadership culture that appreciates the ’ fluid character of warfare in the modern era. Beyond the...of Iraq, reveals that a numl?er of tactical leaders exhibited superb situational awareness and thoughtful response to extremely dynamic security...Paul D. Batchelor , Fixing Intel: · . A B lneprint for Making Intelligence Relevant in Afghanistan, Center for a New American Security, Washington

  13. General George Crook’s development as a practitioner of irregular warfare during the Indian wars. (United States)


    continue to prepare, train, and equip for large-scale peer or near-peer conventional warfare, the breadth of the republic’s history teaches that Irregular...considered many of the officers he encountered to be selfish, self- important, and worse yet, out of touch with the realities facing them. They limited...of Cottonwood generally, thereby virtually acknowledging himself whipped by a small party of Indians and leaving our citizens and their property

  14. Mountain Warfare and Other Lofty Problems: Foreign Perspectives on High-Altitude Combat (United States)


    rope. The two primary ropes should be thoroughly tested when crossing along a rope with a climbing harness and pulley or carabiner. Gear should be...consequently, the Russian Army has a long history of mountain troops, production of specialized mountain warfare gear , and mountain training centers...The mountain units of foreign armies have spent years developing a well-worked-out technique for training Jägers. What gear should you to take to the

  15. Chemical Warfare in World War 1: The American Experience, 1917-1918 (Leavenworth Papers, Number 10) (United States)


    before they reached the front. While moving forward one night toward Chauteau Thierry , the men stopped to rest in shallow shell holes near the road. A...20-23; Curt Wachtel, Chemical Warfare (Brooklyn, NY: Chemical Publishing Co., 1941), 66. 8. Hogg, Gas, 23. 9. Augustin Mitchell Prentiss...Magazine, 10 March 1980:28. Powell, E. Alexander. The Army Behind the Army. New York: Charles Scribner’s Sons, 1919. Prentiss, Augustin Mitchell

  16. Operational advantages of using Cyber Electronic Warfare (CEW) in the battlefield (United States)

    Yasar, Nurgul; Yasar, Fatih M.; Topcu, Yucel


    While cyberspace is emerging as a new battlefield, conventional Electronic Warfare (EW) methods and applications are likely to change. Cyber Electronic Warfare (CEW) concept which merges cyberspace capabilities with traditional EW methods, is a new and enhanced form of the electronic attack. In this study, cyberspace domain of the battlefield is emphazised and the feasibility of integrating Cyber Warfare (CW) concept into EW measures is researched. The SWOT (Strengths, Weaknesses, Opportunities and Threats) analysis method is used to state the operational advantages of using CEW concept in the battlefield. The operational advantages of CEW are assessed by means of its effects on adversary air defense systems, communication networks and information systems. Outstanding technological and operational difficulties are pointed out as well. As a result, a comparison of CEW concept and conventional EW applications is presented. It is concluded that, utilization of CEW concept is feasible at the battlefield and it may yield important operational advantages. Even though the computers of developed military systems are less complex than normal computers, they are not subjected to cyber threats since they are closed systems. This concept intends to show that these closed systems are also open to the cyber threats. As a result of the SWOT analysis, CEW concept provides Air Forces to be used in cyber operations effectively. On the other hand, since its Collateral Damage Criteria (CDC) is low, the usage of cyber electronic attack systems seems to grow up.

  17. [Glanders--a potential disease for biological warfare in humans and animals]. (United States)

    Lehavi, Ofer; Aizenstien, Orna; Katz, Lior H; Hourvitz, Ariel


    Infection with Burkholderia mallei (formerly Pseudomonas mallei) can cause a subcutaneous infection known as "farcy" or can disseminate to condition known as Glanders. It is primarily a disease affecting horses, donkeys and mules. In humans, Glanders can produce four types of disease: localized form, pulmonary form, septicemia, and chronic form. Necrosis of the tracheobronchial tree and pustular skin lesions characterize acute infection with B. mallei. Other symptoms include febrile pneumonia, if the organism was inhaled, or signs of sepsis and multiple abscesses, if the skin was the port of entry. Glanders is endemic in Africa, Asia, the Middle East, and Central and South America. Glanders has low contiguous potential, but because of the efficacy of aerosolized dissemination and the lethal nature of the disease, B. mallei was considered a candidate for biological warfare. During World War I, Glanders was believed to have been spread to infect large numbers of Russian horses and mules on the Eastern front. The Japanese infected horses, civilians and prisoners of war during World War II. The USA and the Soviet Union have shown interest in B. mallei in their biological warfare program. The treatment is empiric and includes mono or poly-therapy with Ceftazidime, Sulfadiazine, Trimethoprim + Sulfamethoxazol, Gentamicin, Imipenem etc. Aggressive control measures essentially eliminated Glanders from the west. However, with the resurgent concern about biological warfare, B. mallei is now being studied in a few laboratories worldwide. This review provides an overview of the disease and presents the only case reported in the western world since 1949.

  18. Fingerprinting malathion vapor: a simulant for VX nerve agent (United States)

    Song, Renbo; Ding, Yujie J.; Zotova, Ioulia B.


    Being motivated by the possibility of fingerprinting and detecting VX nerve agent, we have investigated its stimulant, i.e. malathion vapor, which is less toxic and commercially available, in the far-infrared/THz transition region and THz frequency range. Such a spectroscopic study was carried out by using Fourier transform infrared spectroscopy (FTIR). Our intention is to obtain a specific spectroscopic signature of VX nerve agent as a chemical warfare agent. Following our experimental result, we have successfully observed eleven new absorption peaks from malathion vapor in the spectral ranges from 15 cm -1 to 68 cm -1 and from 75 cm -1 to 640 cm -1. Specifically, in the far-infrared/THz transition region, we have observed eight peaks and whereas in the THz region we have identified three relatively weak transition peaks. In addition, we have investigated the dependence of the absorption spectra on temperature in the range from room temperature to 60°C. In both of the frequency ranges, we have found that absorption coefficients significantly increase with increasing temperature. By comparing the transition peaks in the two frequency ranges, we have concluded that the frequency range of 400-640cm -1 is an optimal range for fingerprinting this chemical specie. We have designated two peaks for effectively and accurately identifying the VX nerve agents and one peak for differentiating between malathion and VX nerve agent.

  19. Skin decontamination of G, V, H L agents by Canadian reactive skin decontaminant lotion

    Energy Technology Data Exchange (ETDEWEB)

    Bide, R.W.; Sawyer, T.W.; DiNinno, V.L.; Armour, S.J.; Risk, D.J.


    The Canadian Reactive Skin Decontaminant Lotion (RSDL) is a reactive solution designed to be applied directly to skin for the decontamination and destruction of the classical chemical warfare agents. The solvent of the RSDL is very effective in dissolving liquid agents from the skin surface and the differential solubility of agents in the RSDL and the skin strongly favors retention of agents in the lotion. The active ingredient in the RSDL reacts rapidly and completely with G-agents, V-agents, mustard Lewisite producing relatively nontoxic products. The RSDL will dissolve and destroy agent thickened with acrylate polymers. The lotion is water soluble and readily removed from the skin. Since the RSDL is water soluble, it is active against water soluble agents even at high dilutions. For water insoluble agents, the activity is reduced as the water content rises above abrasive 50% due to insolubility of the agents. Skin and eye irritancy trials indicate that the RSDL is only a mild irritant to the eyes (equivalent to a chlorinated swimming pool) and to abraded skin. Acute toxicity trials showed that large oral and intraperitoneal doses were essentially non-toxic. The RSDL was fielded by the Canadian Forces for the Gulf Conflict. The RSDL may be used in open wounds for short periods. Wound decontamination and irrigation with RSDL diluted 1:1 with isotonic saline was recommended for the Gulf conflict.

  20. O-Chlorobenzylidene Malononitrile (CS Riot Control Agent) Exposures and Associated Acute Respiratory Illnesses in a United States Army Basic Combat Training Cohort (United States)


    cyanide constituents (Figure 2) (64). It is only slightly soluble in water but readily dissolves in many organic solvents including acetone...capture both the aerosol and vapor phases of CS (68). Regardless of collection method, CS is extracted from the media using 20% methylene an activated carbon filter impregnated with copper, zinc, silver, molybdenum , and triethylenediamine, designed to remove chemical warfare agents

  1. Atmospheric Pressure Plasma Jet for Chem/Bio Warfare Decontamination (United States)

    Herrmann, Hans W.; Henins, Ivars; Park, Jaeyoung; Selwyn, Gary S.


    Atmospheric Pressure Plasma Jet (APPJ) technology may provide a much needed method of CBW decontamination which, unlike traditional decon methods, is dry and nondestructive to sensitive equipment and materials. The APPJ discharge uses a high-flow feedgas consisting primarily of an inert carrier gas, such as He, and a small amount of a reactive additive, such as O2, which flows between capacitively-coupled electrodes powered at 13.56 MHz. The plasma generates highly reactive metastable and atomic species of oxygen which are then directed onto a contaminated surface. The reactive effluent of the APPJ has been shown to effectively neutralize VX nerve agent as well as simulants for anthrax and mustard blister agent. Research efforts are now being directed towards reducing He consumption and increasing the allowable stand-off distance. Recent results demonstrate that by replacing the O2 reactive additive with CO2, ozone formation is greatly reduced. This has the result of extending the lifetime of atomic oxygen by an order of magnitude or more. A recirculating APP Decon Chamber which combines heat, vacuum, forced convection and reactivity is currently being developed for enhanced decontamination of sensitive equipment. Several techniques are also being evaluated for use in an APP Decon Jet for decontamination of items which cannot be placed inside a chamber.





    Mobile agent technology has been promoted as an emerging technology that makes it much easier to design, implement, and maintain distributed systems, introduction to basic concepts of mobile agents like agent mobility, agent types and places and agent communication. Then benefits of the usage of mobile agents are summarized and illustrated by selected applications. The next section lists requirements and desirable properties for mobile agent languages and systems. We study the main features, ...

  3. Development of an automated sample preparation module for environmental monitoring of biowarfare agents. (United States)

    Hindson, Benjamin J; Brown, Steve B; Marshall, Graham D; McBride, Mary T; Makarewicz, Anthony J; Gutierrez, Dora M; Wolcott, Duane K; Metz, Thomas R; Madabhushi, Ramakrishna S; Dzenitis, John M; Colston, Billy W


    An automated sample preparation module, based upon sequential injection analysis (SIA), has been developed for use within an autonomous pathogen detection system. The SIA system interfaced aerosol sampling with multiplexed microsphere immunoassay-flow cytometric detection. Metering and sequestering of microspheres using SIA was found to be reproducible and reliable, over 24-h periods of autonomous operation. Four inbuilt immunoassay controls showed excellent immunoassay and system stability over five days of unattended continuous operation. Titration curves for two biological warfare agents, Bacillus anthracis and Yersinia pestis, obtained using the automated SIA procedure were shown to be similar to those generated using a manual microtiter plate procedure.

  4. Hand-Held Devices Detect Explosives and Chemical Agents (United States)


    Ion Applications Inc., of West Palm Beach, Florida, partnered with Ames Research Center through Small Business Innovation Research (SBIR) agreements to develop a miniature version ion mobility spectrometer (IMS). While NASA was interested in the instrument for detecting chemicals during exploration of distant planets, moons, and comets, the company has incorporated the technology into a commercial hand-held IMS device for use by the military and other public safety organizations. Capable of detecting and identifying molecules with part-per-billion sensitivity, the technology now provides soldiers with portable explosives and chemical warfare agent detection. The device is also being adapted for detecting drugs and is employed in industrial processes such as semiconductor manufacturing.

  5. Ultrahigh Vacuum Studies of the Fundamental Interactions of Chemical Warfare Agents and Their Simulants with Amorphous Silica (United States)


    respiratory tissues. Common first symptoms include lacrimation, salivation, coughing, and vomiting . However, these symptoms are rarely observed...description of the doser can be found in Larry Fiegland’s dissertation.68 The second doser is a variable sapphire-plate precision leak valve (Duniway

  6. Developmental Toxic Effects of Exposure to Chemical Warfare Nerve Agents in Rats: Effects on Brain and Behavior (United States)


    stimulation of acetylcholine receptors. Common consequences of this cholinergic crisis include seizure activity, neuronal damage and behavioral deficits. The...current study, male and female rats exposed to sarin (GB) were evaluated on tests of spatial memory, locomotor activity and vestibular motor well as neuropathology. Similar to our adult model, we found that juvenile rats exposed to GB exhibited deficits in vestibular motor function for

  7. Evaporation Rates of Chemical Warfare Agents Measured using 5 cm Wind Tunnels III. Munition-Grade Sulfur Mustard on Concrete (United States)


    from glass occurred from a sessile droplet with a constant base and the contact angle changing during the evaporation.1" Previous studies also...Hg Parameters Adv. Contact Angle : 130.000 degrees Rec. Contact Angle : Hg Surface Tension: 485.000 dynes/cm Hg Density: Low Pressure...temperature, drop size, and air flow rate using the same instrumentation as prior studies on glass and sand. The evaporation rate increased with higher

  8. Developmental Toxic Effects of Exposure to Chemical Warfare Nerve Agents in Rats: Effects on Brain and Behavior (United States)


    spatial memory, locomotor activity and vestibular motor function , as well as neuropathology. Similar to our adult model, we found that juvenile...rats exposed to GB exhibited deficits in vestibular motor function for up to 1 week and cognitive deficits in the Morris water maze at 3 weeks post...Preparation of rat brains for Golgi-Cox staining: Upon euthanasia, the brain of each animal was carefully removed from the skull. The cerebrum was blocked

  9. Metal Ion-Catalyzed Alcoholysis as a Strategy for the High Loading Destruction of Chemical Warfare Organophosphorus Agents (United States)


    and reaction products were obtained by NMR or gas chromatography – mass spectrometry (GC-MS), and, in the case of VX, also by liquid chromatography ...Thus, at the end of the project period of performance, the adaption of two new techniques was in progress: a liquid chromatography –tandem mass...of VX Simulants by Micellar Iodoso- and Iodoxybenzoate. Langmuir 1999, 15(23), pp 8113–8118. 47. Berg, F.J.; Moss, R.A.; Yang, Y.-C.; Zhang, H

  10. Evaporation Rates of Chemical Warfare Agents Measured Using 5 CM Wind Tunnels. 2. Munitions Grade Sulfur Mustard From Sand (United States)


    was obtained from the back gate of Cannon AFB, New Mexico , and is a surface sample. Chemical analyses are in Appendix E, and surface area data are...m t*5 ft ft cO o o . a* a* «•! if- 6* s* £ aci/i^iotr- vino *» in K c\\ v " tv O O O) 00 f* tf- (T rf

  11. Infrared Spectra and Binding Energies of Chemical Warfare Nerve Agent Simulants on the Surface of Amorphous Silica (United States)


    such as DMMP and DFP. While many groups have investigated the fundamental interactions between select organophosphorous compounds and silica, many...substituents within organophosphorous compounds (a key characteristic of the CWAs sarin and soman7) affect the strength of hydrogen-bond formation on silica...the bonding geometries and electronic structure of the organophosphorous compounds on silica. Furthermore, the calculations enable us to explore

  12. Multifunctional Ultra-High Vacuum Apparatus for Studies of the Interactions of Chemical Warfare Agents on Complex Surfaces (United States)


    on gamma alumina surfaces. This work was followed by other investigations of organophosphate CWA decomposition on alumina.35 In addition, Wagner and...nm particle di- ameter) was chosen as the first surface to study because the adsorption of many organophosphate molecules (simu- lants) to silica has...Kondratyuk, and J. T. Yates, “Photooxidation of a mus- tard gas simulant over TiO2-SiO2 mixed-oxide photocatalyst: Site poison - ing by oxidation products

  13. Chemical Warfare Agent Decontamination Efficacy Testing Large-Scale Chamber mVHP (registered trademerk) Decontamination System Evaluation (United States)


    06 Wipe HD 500 30 27.1 ±0.3 18.5 ± 1.6 24 01- Mar -06 Wipe HD 500 30 27.2 ±0.3 12.2 ±1.6 31 (HDE) 22-Feb-06 Extr. Eff. HD 0 0 N/A N/A 7 08-Dec-05...19.1 ±3.2 17 25-Jan-06 Efficacy VX 500 30 27.4 ±0.5 17.7 ±1.4 34(17R) 15- Mar -06 Efficacy VX 500 30 27.8 ±0.3 15.9 ±1.4 30 27- Mar -06 Efficacy VX 500 30...flow - 20 mL/min purge time - 1 min minimum carrier pressure - 5 psi purge flow - 20 mL/min ola split flow - 20 mL/min oven temperature 1 - 250 °C

  14. Immobilization of Enzymes in Nanoporous Host Materials: A Nanobiotechnological Approach to Decontamination and Demilitarization of Chemical and Biological Warfare Agents (United States)


    Type IV with H2 hysteresis loop, typical of mesoporous materials. The incorporation of the methyl group into the silica matrix (OPAA-HF series samples...compared to that of the immobilized enzymes in TMOS-derived materials. The non-surfactant template pathway58-59 to the mesoporous silica materials...biocatalyst OPAA into mesoporous silica host materials of various compositions. OPAA was chosen owing to its ability to catalyze the hydrolysis of highly

  15. Evaporation Rates of Chemical Warfare Agents Using 5-CM Wind Tunnels I. CASARM Sulfur Mustard (HD) from Glass (United States)


    CUI/6LU ui QH I- Q- s" i TO (0 ’_ r_ E u 5 i CL E (/> TJ I- Q E E en O co o o 3 C1 Q X S w w o Q. (- o < 0) s...jg O 10 •3 F P) » e o rv •* tf 0*. IN a: <•-* Pi N in <^* 8 <l V2 .-• O o C1 rj p* DA oc r- r-> - t* n -. c* >. 5 D * C" c:v- 1...N. *"*- K tO cU fVj x- t- • •>- tsg »- ,_ PJ ^ _. ,- r- ,.. •• NrNrrN(N1(\\0)(\\ nif ) c^ it o o> O E O O 9 O 9

  16. Synthesis and Performance of a Biomimetic Indicator for Alkylating Agents. (United States)

    Provencher, Philip A; Love, Jennifer A


    4-(4-Nitrobenzyl)pyridine (NBP) is a colorimetric indicator compound for many types of carcinogenic alkylating agents. Because of the similar reactivity of NBP and guanine in DNA, NBP serves as a DNA model. NBP assays are used in the toxicological screening of pharmaceutical compounds, detection of chemical warfare agents, environmental hygiene technology, preliminary toxicology tests, mutagenicity of medicinal compounds, and other chemical analyses. Nevertheless, the use of NBP as a DNA model suffers from the compound's low water solubility, its lack of reactive oxygen sites, and dissimilar steric encumbrance compared to DNA. We report herein the design and synthesis of NBP derivatives that address some of these issues. These derivatives have been tested in solution and found to be superior in the colorimetric assay of the alkylating anticancer drug cyclophosphamide. The derivatives have also been integrated into a polymeric silica material which changes color upon the exposure to dangerous alkylating agents, such as iodomethane vapor, without the need for an exogenous base. This material modernizes the NBP assay from a time-consuming laboratory analysis to a real-time solid state sensor, which requires neither solvent nor additional reagents and can detect both gas- and solution-phase alkylating agents.

  17. Extraction of nerve agent VX from soils. (United States)

    Montauban, Cécile; Bégos, Arlette; Bellier, Bruno


    The development and optimization of a method allowing the extraction of intact organophosphorus chemical warfare agent O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothiolate (VX) from several types of soils are presented here. This involved the selection of an appropriate buffer to bring the sample to a pH close to the pK(a) of VX but sufficiently low to avoid its basic hydrolysis. Buffering with Tris (pH 9) and subsequent extraction of the aqueous layer by a 85:15 (v/v) hexane/dichloromethane mixture allows rapid and sensitive flame photometric detection of VX at spiking levels lower than 10 microg x g(-1), even after 3 months of aging. Extraction yields were close to 60% in complex matrixes. This method also allows recovery and identification of a characteristic degradation product of VX, bis(2-diisopropylaminoethyl) disulfide, which appears to be formed during the aging process. The performance of this method is far better than that of OPCW reference operating procedure, which does not allow extraction of detectable amounts of VX (spiked at 10 microg x g(-1)) in one of the soils used for this study.

  18. Genotoxicity of the phosphoramidate agent tabun (Ga). (Reannouncement with new availability information)

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, B.W.; Kawakami, T.G.; Cone, N.; Henderson, J.D.; Rosenblatt, L.S.


    Five mutagenicity tests were performed on Agent GA (Tabun, phosphoramidocyanidic acid, dimethyl-, ethyl ester) as part of a program to demilitarize chemical warfare agents. GA was mutagenic in Salmonella spp. assays with S-9 and it was a direct-acting mutagen to mouse lymphoma cells. GA did not promote unscheduled DNA synthesis in rat hepatocytes; it induced sister chromatid exchanges in mouse cells in vitro but not in vivo. The conclusion that GA is a weakly acting mutagen is supported by the fact that it was mutagenic in only three of the five assays, and that increases in mutagenicity were often less than 2-fold the controls and occurred near toxic levels. Tabun, Agent GA, Phosphoroamidocyanidic acid, Dimethyl-, Ethyl ester, Genotoxicity, Mutagenic assays.

  19. Metabolic network analysis-based identification of antimicrobial drug targets in category A bioterrorism agents. (United States)

    Ahn, Yong-Yeol; Lee, Deok-Sun; Burd, Henry; Blank, William; Kapatral, Vinayak


    The 2001 anthrax mail attacks in the United States demonstrated the potential threat of bioterrorism, hence driving the need to develop sophisticated treatment and diagnostic protocols to counter biological warfare. Here, by performing flux balance analyses on the fully-annotated metabolic networks of multiple, whole genome-sequenced bacterial strains, we have identified a large number of metabolic enzymes as potential drug targets for each of the three Category A-designated bioterrorism agents including Bacillus anthracis, Francisella tularensis and Yersinia pestis. Nine metabolic enzymes- belonging to the coenzyme A, folate, phosphatidyl-ethanolamine and nucleic acid pathways common to all strains across the three distinct genera were identified as targets. Antimicrobial agents against some of these enzymes are available. Thus, a combination of cross species-specific antibiotics and common antimicrobials against shared targets may represent a useful combinatorial therapeutic approach against all Category A bioterrorism agents.

  20. Metabolic network analysis-based identification of antimicrobial drug targets in category A bioterrorism agents.

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    Yong-Yeol Ahn

    Full Text Available The 2001 anthrax mail attacks in the United States demonstrated the potential threat of bioterrorism, hence driving the need to develop sophisticated treatment and diagnostic protocols to counter biological warfare. Here, by performing flux balance analyses on the fully-annotated metabolic networks of multiple, whole genome-sequenced bacterial strains, we have identified a large number of metabolic enzymes as potential drug targets for each of the three Category A-designated bioterrorism agents including Bacillus anthracis, Francisella tularensis and Yersinia pestis. Nine metabolic enzymes- belonging to the coenzyme A, folate, phosphatidyl-ethanolamine and nucleic acid pathways common to all strains across the three distinct genera were identified as targets. Antimicrobial agents against some of these enzymes are available. Thus, a combination of cross species-specific antibiotics and common antimicrobials against shared targets may represent a useful combinatorial therapeutic approach against all Category A bioterrorism agents.