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Sample records for wales prospective derivation

  1. Traumatic brain injury in England and Wales: prospective audit of epidemiology, complications and standardised mortality.

    Science.gov (United States)

    Lawrence, T; Helmy, A; Bouamra, O; Woodford, M; Lecky, F; Hutchinson, P J

    2016-11-24

    To provide a comprehensive assessment of the management of traumatic brain injury (TBI) relating to epidemiology, complications and standardised mortality across specialist units. The Trauma Audit and Research Network collects data prospectively on patients suffering trauma across England and Wales. We analysed all data collected on patients with TBI between April 2014 and June 2015. Data were collected on patients presenting to emergency departments across 187 hospitals including 26 with specialist neurosurgical services, incorporating factors previously identified in the Ps14 multivariate logistic regression (Ps14 n ) model multivariate TBI outcome prediction model. The frequency and timing of secondary transfer to neurosurgical centres was assessed. We identified 15 820 patients with TBI presenting to neurosurgical centres directly (6258), transferred from a district hospital to a neurosurgical centre (3682) and remaining in a district general hospital (5880). The commonest mechanisms of injury were falls in the elderly and road traffic collisions in the young, which were more likely to present in coma. In severe TBI (Glasgow Coma Score (GCS) ≤8), the median time from admission to imaging with CT scan is 0.5 hours. Median time to craniotomy from admission is 2.6 hours and median time to intracranial pressure monitoring is 3 hours. The most frequently documented complication of severe TBI is bronchopneumonia in 5% of patients. Risk-adjusted W scores derived from the Ps14 n model indicate that no neurosurgical unit fell outside the 3 SD limits on a funnel plot. We provide the first comprehensive report of the management of TBI in England and Wales, including data from all neurosurgical units. These data provide transparency and suggests equity of access to high-quality TBI management provided in England and Wales. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  2. Traumatic brain injury in England and Wales: prospective audit of epidemiology, complications and standardised mortality

    Science.gov (United States)

    Lawrence, T; Bouamra, O; Woodford, M; Lecky, F; Hutchinson, P J

    2016-01-01

    Objectives To provide a comprehensive assessment of the management of traumatic brain injury (TBI) relating to epidemiology, complications and standardised mortality across specialist units. Design The Trauma Audit and Research Network collects data prospectively on patients suffering trauma across England and Wales. We analysed all data collected on patients with TBI between April 2014 and June 2015. Setting Data were collected on patients presenting to emergency departments across 187 hospitals including 26 with specialist neurosurgical services, incorporating factors previously identified in the Ps14 multivariate logistic regression (Ps14n) model multivariate TBI outcome prediction model. The frequency and timing of secondary transfer to neurosurgical centres was assessed. Results We identified 15 820 patients with TBI presenting to neurosurgical centres directly (6258), transferred from a district hospital to a neurosurgical centre (3682) and remaining in a district general hospital (5880). The commonest mechanisms of injury were falls in the elderly and road traffic collisions in the young, which were more likely to present in coma. In severe TBI (Glasgow Coma Score (GCS) ≤8), the median time from admission to imaging with CT scan is 0.5 hours. Median time to craniotomy from admission is 2.6 hours and median time to intracranial pressure monitoring is 3 hours. The most frequently documented complication of severe TBI is bronchopneumonia in 5% of patients. Risk-adjusted W scores derived from the Ps14n model indicate that no neurosurgical unit fell outside the 3 SD limits on a funnel plot. Conclusions We provide the first comprehensive report of the management of TBI in England and Wales, including data from all neurosurgical units. These data provide transparency and suggests equity of access to high-quality TBI management provided in England and Wales. PMID:27884843

  3. An Australasian assessment of the basic treatment equivalent model derived from New South Wales data

    International Nuclear Information System (INIS)

    Delaney, G.; Gebski, V.; Sydney University, NSW; Lunn, A.D.; Open University, Milton Keynes,; Oxford University, Oxford,; Lunn, M.; Oxford University, Oxford,

    1999-01-01

    The current method of assessment of radiation oncology linear accelerator throughput is either by patients per unit time or fields per unit time. This, however, does not take into consideration the complexity of different treatment techniques or of case mix. A model has been developed in an earlier study, called 'basic treatment equivalent' (BTE), to measure patient throughput of a linear accelerator, which includes consideration of the complexity of treatment techniques. The present study compared the BTE model with the current best measure of patient throughput of fields per hour. All 37 departments in Australia and New Zealand were invited to participate in testing the model, and 36 agreed to participate. The study period for each department was a consecutive 4 weeks between August and December, 1996. The prospective data collected were the total BTE units treated per linear accelerator per day, the total number of patients and fields treated per linear accelerator per day, and the total linear accelerator hours of operation per day excluding calibration time and significant breaks of linear accelerator time such as planned meal breaks. The treatment breaks between consecutive treatment fractions were not excluded from the linear accelerator treatment time. The throughput data for 36 departments (92 linear accelerators) were collected over the 4-week study period. The average throughput for the departments was 10.8 fields per hour and 4.2 patients per hour. The average BTE per department was 5.7 BTE per hour. The average BTE per episode per department was 1.38. The BTE model was found to be a more sensitive measure of productivity compared with fields per hour (P < 0.001). Some treatment techniques were thought to be not well represented by the BTE formula, particularly those techniques where junctions were present. The BTE model is a more sensitive measure than fields per hour and better reflects the variations in complexity in techniques. Despite this result

  4. Electricity sales prospects for a landfill gas generator acting as a second tier supplier in England and Wales

    International Nuclear Information System (INIS)

    1996-01-01

    Following the liberalisation of the United Kingdom electricity market, there are now a growing number of companies trying to develop small generation projects based on a landfill gas fuel source. Because of their size they will typically be connected to the electricity distribution system and as such not using the transmission system -with all of the power typically being absorbed locally. In common with grid connected projects, these smaller 'embedded' generators must be able to: be connected to the system; have a market for their product; and be reasonably certain of the price they can receive for the power that they produce, in order to develop a business case and, if necessary raise finance for the scheme. Generators in England and Wales that have a capacity of less than 50MW do not need a Generation Licence, and as such have no 'natural' market for their power, even though it may be potentially more valuable than power sold by licensed generators into the Pool. The logical purchaser for this local power would normally be the host electricity supply company as they own and control the distribution network up to and including 132kV. (Author)

  5. Potential for cadaveric organ retrieval in New South Wales.

    OpenAIRE

    Hibberd, A. D.; Pearson, I. Y.; McCosker, C. J.; Chapman, J. R.; Macdonald, G. J.; Thompson, J. F.; O'Connell, D. L.; Mohacsi, P. J.; McLoughlin, M. P.; Spratt, P. M.

    1992-01-01

    OBJECTIVES--To measure the potential for cadaver organ retrieval in New South Wales and to determine the reasons for potential donors failing to become actual donors. DESIGN--Prospective audit of all patients dying in five hospitals in New South Wales between 1 December 1989 and 30 November 1990; quality assurance of the data by independent medical specialist and if disagreement by study committee. PATIENTS--2879 patients (100% of all deaths) yielding 364 patients with coma and 181 potential ...

  6. Newly synthesized benzanthrone derivatives as prospective fluorescent membrane probes

    International Nuclear Information System (INIS)

    Zhytniakivska, Olga; Trusova, Valeriya; Gorbenko, Galyna; Kirilova, Elena; Kalnina, Inta; Kirilov, Georgiy; Kinnunen, Paavo

    2014-01-01

    Fluorescence spectral properties of a series of novel benzanthrone derivatives have been explored in lipid bilayers composed of zwitterionic lipid phosphatidylcholine (PC) and its mixtures with cholesterol (Chol) and anionic phospholipid cardiolipin (CL). Analysis of partition coefficients showed that all the examined compounds possess rather high lipid-associating ability, with the amidino derivatives exhibiting stronger membrane partitioning compared with the aminobenzanthrones. To understand how benzanthrone partition properties correlate with their structure, quantitative structure property relationship (QSPR) analysis was performed involving a range of quantum chemical molecular descriptors. -- Highlights: • Benzanthrone partitioning into lipid bilayer correlates with lipophilicity of the dyes. • Partition properties of benzanthrones depend on the dye dipole moment. • Amidino derivatives exhibit higher membrane affinity than aminobenzanthrones

  7. Cinnamic acid derivatives in cosmetics - current use and future prospects.

    Science.gov (United States)

    Gunia-Krzyżak, Agnieszka; Słoczyńska, Karolina; Popiół, Justyna; Koczurkiewicz, Paulina; Marona, Henryk; Pękala, Elżbieta

    2018-06-05

    Cinnamic acid derivatives are widely used in cosmetics and possess various functions. This group of compounds includes both naturally occurring as well as synthetic substances. On the basis of the Cosmetic Ingredient Database (CosIng) and available literature, this review summarizes their functions in cosmetics, including their physicochemical and biological properties as well as reported adverse effects. A perfuming function is typical of many derivatives of cinnamaldehyde, cinnamyl alcohol, dihydrocinnamyl alcohol, and cinnamic acid itself; these substances are commonly used in cosmetics all over the world. Some of them show allergic and photoallergic potential, resulting in restrictions in maximum concentrations and/or a requirement to indicate the presence of some substances in the list of ingredients when their concentrations exceed certain fixed values in a cosmetic product. Another important function of cinnamic acid derivatives in cosmetics is UV protection. Ester derivatives such as ethylhexyl methoxycinnamate (octinoxate), isoamyl p-methoxycinnamte (amiloxiate), octocrylene, and cinoxate are used in cosmetics all over the world as UV filters. However, their maximum concentrations in cosmetic products are restricted due to their adverse effects, which include contact and a photocontact allergies, phototoxic contact dermatitis, contact dermatitis, estrogenic modulation, and generation of reactive oxygen species. Other rarely utilized functions of cinnamic acid derivatives are as an antioxidant, in skin conditioning, hair conditioning, as a tonic, and in antimicrobial activities. Moreover, some currently investigated natural and synthetic derivatives of cinnamic acid have shown skin lightening and anti-aging properties. Some of them may become new cosmetic ingredients in the future. In particular, 4-hydroxycinnamic acid, which is currently indexed as a skin-conditioning cosmetics ingredient, has been widely tested in vitro and in vivo as a new drug candidate

  8. Deriving optimal exploration target zones on mineral prospectivity maps

    CSIR Research Space (South Africa)

    Debba, Pravesh

    2008-08-01

    Full Text Available into an objective function in simulated annealing in order to derive a set of optimal exploration focal points. Each optimal exploration focal point represents a pixel or location within a circular neighborhood of pixels with high posterior probability of mineral...

  9. Great Prospects for PAF-1 and its derivatives

    KAUST Repository

    Pei, Cuiying

    2015-01-01

    © The Royal Society of Chemistry 2015. In materials design and preparative chemistry, it is imperative to understand the thought and logic behind synthesizing a particular kind of material. Computational modelling can help in this regard by not only optimizing the materials but also by simulating their properties. Furthermore, the experimental results fill the gap addressing complicated practical conditions that can\\'t be covered using theoretical calculations. In this work, we focus on PAF-1 and its derivatives in order to analyse the correlations between the nature of the material (e.g. pore size, surface area, pore volume, functional groups, metal sites, interpenetrated frameworks) and their properties such as gas sorption capacity, molecular recognition and separation.

  10. Hyperbranched Polyglycerol Derivatives as Prospective Copper Nanotransporter Candidates

    Directory of Open Access Journals (Sweden)

    Mohiuddin Quadir

    2018-05-01

    Full Text Available Hyperbranched polyglycerol (hPG has been used as a multivalent scaffold to develop a series of nanocarriers capable of high-affinity encapsulation of copper (Cu. A rationally selected set of Cu-complexing motifs has been conjugated to hPG hydroxyl groups to render the constructs potentially usable as exogenous sources of Cu for addressing different pathological conditions associated with Cu-deficiency. We have utilized a newly discovered route to attach Cu-binding domains exclusively within a hPG core by selective differentiation between the primary and secondary hydroxyl groups of the polyol. These hPG-derivatives were found to form a stable complex with Cu ions depending on the type of immobilized ligands and corresponding degree of functionalization. In addition, these Cu-bearing nano-complexes demonstrated moderately cationic surface charge resulting in adjustable protein-binding characteristics and low cellular toxicity profile. We envision that these Cu-loaded hPG nanocarriers can be used as a stable platform to transport the metal ion across the systemic circulation to supply bioavailable quantity of Cu in disease-afflicted tissues.

  11. High frequency audiometry in prospective clinical research of ototoxicity due to platinum derivatives

    NARCIS (Netherlands)

    van der Hulst, R. J.; Dreschler, W. A.; Urbanus, N. A.

    1988-01-01

    The results of clinical use of routine high frequency audiometry in monitoring the ototoxic side effects of platinum and its derivatives are described in this prospective study. After demonstrating the reproducibility of the technique, we discuss the first results of an analysis of ototoxic side

  12. Evaluation of the national Cleanyourhands campaign to reduce Staphylococcus aureus bacteraemia and Clostridium difficile infection in hospitals in England and Wales by improved hand hygiene: four year, prospective, ecological, interrupted time series study.

    Science.gov (United States)

    Stone, Sheldon Paul; Fuller, Christopher; Savage, Joan; Cookson, Barry; Hayward, Andrew; Cooper, Ben; Duckworth, Georgia; Michie, Susan; Murray, Miranda; Jeanes, Annette; Roberts, J; Teare, Louise; Charlett, Andre

    2012-05-03

    To evaluate the impact of the Cleanyourhands campaign on rates of hospital procurement of alcohol hand rub and soap, report trends in selected healthcare associated infections, and investigate the association between infections and procurement. Prospective, ecological, interrupted time series study from 1 July 2004 to 30 June 2008. 187 acute trusts in England and Wales. Installation of bedside alcohol hand rub, materials promoting hand hygiene and institutional engagement, regular hand hygiene audits, rolled out nationally from 1 December 2004. Quarterly (that is, every three months) rates for each trust of hospital procurement of alcohol hand rub and liquid soap; Staphylococcus aureus bacteraemia (meticillin resistant (MRSA) and meticillin sensitive (MSSA)) and Clostridium difficile infection for each trust. Associations between procurement and infection rates assessed by mixed effect Poisson regression model (which also accounted for effect of bed occupancy, hospital type, and timing of other national interventions targeting these infections). Combined procurement of soap and alcohol hand rub tripled from 21.8 to 59.8 mL per patient bed day; procurement rose in association with each phase of the campaign. Rates fell for MRSA bacteraemia (1.88 to 0.91 cases per 10,000 bed days) and C difficile infection (16.75 to 9.49 cases). MSSA bacteraemia rates did not fall. Increased procurement of soap was independently associated with reduced C difficile infection throughout the study (adjusted incidence rate ratio for 1 mL increase per patient bed day 0.993, 95% confidence interval 0.990 to 0.996; P hospital procurement of alcohol rub and soap, which the results suggest has an important role in reducing rates of some healthcare associated infections. National interventions for infection control undertaken in the context of a high profile political drive can reduce selected healthcare associated infections.

  13. Analysis of the learning curve for pre-cut corneal specimens in preparation for lamellar transplantation: a prospective, single-centre, consecutive case series prepared at the Lions New South Wales Eye Bank.

    Science.gov (United States)

    Martin, Aifric Isabel; Devasahayam, Rajnesh; Hodge, Christopher; Cooper, Simon; Sutton, Gerard L

    2017-09-01

    This study is the first paper to establish a learning curve by a single technician. Preparation of pre-cut corneal endothelial grafts commenced at Lions New South Wales Eye Bank in December 2014. The primary objective of this study was to review the safety and reliability of the preparation method during the first year of production. This is a hospital-based, prospective case series. There were 234 consecutive donor corneal lenticules. Donor lenticules were prepared by a single operator using a linear cutting microkeratome. Immediately prior to cutting, central corneal thickness values were recorded. Measurements of the corneal bed were taken immediately following lenticule preparation. Outcomes were separated by blade sizes, and intended thickness was compared to actual thickness for each setting. Early specimens were compared to later ones to assess for a learning curve within the technique. The main parameter measured is the mean difference from intended lamellar cut thickness. The mean final cut thickness was 122.36 ± 20.35 μm, and the mean difference from intended cut was 30.17 ± 37.45 μm. No significant difference was found between results achieved with early specimens versus those achieved with later specimens (P = 0.425). Thin, reproducible endothelial grafts can routinely be produced by trained technicians at their respective eye banks without significant concerns for an extended learning curve. This service can reduce perioperative surgical complexity, required surgical paraphernalia and theatre times. The consistent preparation of single-pass, ultrathin pre-cut corneas may have additional advantages for surgeons seeking to introduce lamellar techniques. © 2017 Royal Australian and New Zealand College of Ophthalmologists.

  14. The Conditions of Creation and Prospects of Weather Derivatives Development on the Domestic Market

    Directory of Open Access Journals (Sweden)

    Piotr Binkowski

    2008-06-01

    Full Text Available Analysing the possibility of creations and prospects of weather derivatives development on the domestic market the first of all should be identify the business areas that are strongly exposed for weather risk, which are: energy, agricultural, building and transportation. The specificity of the Polish climate is the high volatility of the major weather factors like temperature or precipitations. Similar to other European countries where weather derivatives markets already exist (e.g.: Germany, France, and United Kingdom. Having in mind dynamic grow of companies with regards to management processes, used technologies and marketing strategies, the exposure for weather risk is getting higher. Therefore, there is a strong pressure for creation of mechanisms and instruments that will allow reducing that kind of risks. Currently in Poland there are no conditions for development of weather derivatives market due to lack of demand. That situation is caused by low level of awareness regarding to possibilities of reducing weather risks. Within a few years the demand for such the instruments will appear ñ together with growing awareness. Once the demand for weather derivative will appear, the existing infrastructure of financial sector is ready for its implementation. Of course it is hard to say what will be the direction of whether derivatives grow on the domestic financial market but taking into consideration its dynamic grow and strong correlations with global markets, there is a small probability that weather derivatives will not appear on the Polish market ñ it is only the matter of time.

  15. Prospective study for the production of oleochemicals derivates from palm and palm kernel oil in Colombia

    Directory of Open Access Journals (Sweden)

    Diana Ibeth Jaimes Moreno

    2003-01-01

    Full Text Available There are many ways get close to the future, being the prospective the one that concives the future, not like an unique reality but like a multiple one, obtained as a result of the identification of the human being future actions. For all this, the human being takes the knowledge, the yearnings and the fears that he sees for the actions he will undertake. Keeping in mind the characteristic of the palm cultivation (pereninal, of late growth, with a 25 years productive horizon, and the future of the sector captured in "Visión y estrategias de la palmicultura colombiana 2000 - 2020" together with the economic tendencies of the world, the methodology of planning denominated prospective, becomes an appropriate tool to establish the future of the oleochemical sector derived from the palm and palmist oils, which is right now very incipient in our country. Using the prospective, this article outlines the dynamics that will have the sector, starting from the definition of the keys that define the current and future behavior of the system, the position and the power that each one of the involved actors will have, and the determination of the scenarios (future representations will more probability to occur, as well as the definition of the scenario wanted and the strategies that will allow to reach it.

  16. Recent developments and future prospects on bio-based polyesters derived from renewable resources: A review.

    Science.gov (United States)

    Zia, Khalid Mahmood; Noreen, Aqdas; Zuber, Mohammad; Tabasum, Shazia; Mujahid, Mohammad

    2016-01-01

    A significantly growing interest is to design a new strategy for development of bio-polyesters from renewable resources due to limited fossil fuel reserves, rise of petrochemicals price and emission of green house gasses. Therefore, this review aims to present an overview on synthesis of biocompatible, biodegradable and cost effective polyesters from biomass and their prospective in different fields including packaging, coating, tissue engineering, drug delivery system and many more. Isosorbide, 2,4:3,5-di-O-methylene-d-mannitol, bicyclic diacetalyzed galactaric acid, 2,5-furandicarboxylic acid, citric, 2,3-O-methylene l-threitol, dimethyl 2,3-O-methylene l-threarate, betulin, dihydrocarvone, decalactone, pimaric acid, ricinoleic acid and sebacic acid, are some important monomers derived from biomass which are used for bio-based polyester manufacturing, consequently, replacing the petrochemical based polyesters. The last part of this review highlights some recent advances in polyester blends and composites in order to improve their properties for exceptional biomedical applications i.e. skin tissue engineering, guided bone regeneration, bone healing process, wound healing and wound acceleration. Copyright © 2015 Elsevier B.V. All rights reserved.

  17. Hydrogeological reconnaissance study: Dyfi Valley, Wales

    International Nuclear Information System (INIS)

    Glendining, S.J.

    1981-10-01

    This report describes work carried out for the Department of the Environment as part of its research programme into radioactive waste management. It presents an account of a hydrogeological reconnaissance study in the Dyfi Valley area of Central Wales. Initially the purposes of such a study are given and the assumptions used in deriving parameters such as flow volume, path length and transit time in areas of massive fractured rocks are described. Using these assumptions with geological, topographic and hydrometeorological data the potential ranges in properties such as bulk hydraulic conductivity, path lengths, hydraulic gradients and volumes of groundwater flow have been determined. These ranges have been used to estimate solute transport model parameters. The limitations and usefulness of the reconnaissance study in planning research and siting exploratory boreholes in the Dyfi area are discussed. (author)

  18. Marine Science in Southern Wales.

    Science.gov (United States)

    1980-11-05

    George Deacon, founder and formerly head of the UK Institute of Oceanographic Sciences, and Sir Alister Hardy, professor emeritus from Oxford University... head up the new oceandraphy program at its inception. Undergraduate teaching began in 1968 with 30 students, and the first gradu- ates in oceanography...Wales. Zoology Prof. E.W. Knight-Jones collaborates with his wife, Phyllis, in the study of the nervous systems, behavior, and embryology of enteropneusta

  19. Suicide in murderers in England and Wales.

    Science.gov (United States)

    Lester, David

    2003-06-01

    In England and Wales, the suicide rate of murderers was positively associated with the male suicide rate in the general population, and both of these rates were positively associated with the unemployment rate.

  20. Subsurface structure identification uses derivative analyses of the magnetic data in Candi Umbul-Telomoyo geothermal prospect area

    Science.gov (United States)

    Septyasari, U.; Niasari, S. W.; Maghfira, P. D.

    2018-04-01

    Telomoyo geothermal prospect area is located in Central Java, Indonesia. One of the manifestations around Telomoyo is a warm spring, called Candi Umbul. The hydrothermal fluids from the manifestation could be from the subsurface flowing up through geological structures. The previous research about 2D magnetic modeling in Candi Umbul showed that there was a normal fault with strike/dip N60°E/45° respectively. This research aims to know the distance boundary and the kind of the geological structure in the study area. We also compared the geological structure direction based on the geologic map and the derivative maps. We used derivative analyses of the magnetic data, i.e. First Horizontal Derivative (FHD) which is the rate of change of the horizontal gradient in the horizontal direction. FHD indicates the boundaries of the geological structure. We also used Second Vertical Derivative (SVD) which is the rate of change of the vertical gradient in the vertical direction. SVD can reveal normal fault or thrust fault. The FHD and SVD maps show that the geological structure boundary has the same direction with the north west-south east geological structure. The geological structure boundary is in 486 m of the local distance. Our result confirms that there is a normal fault in the study area.

  1. Trends in violence in England and Wales 2010-2014.

    Science.gov (United States)

    Sivarajasingam, Vaseekaran; Page, Nicholas; Wells, John; Morgan, Peter; Matthews, Kent; Moore, Simon; Shepherd, Jonathan

    2016-06-01

    The National Violence Surveillance Network (NVSN) of emergency departments (ED), minor injuries units and walk-in-centres in England and Wales has brought clarity to contradictory violence trends derived from crime survey and police data. Gender, age-specific and regional trends in violence-related injury in England and Wales since 2010 have not been studied. Data on violence-related injury were collected from a structured sample of 151 EDs in England and Wales. ED attendance date and age and gender of patients who reported injury in violence from 1 January 2010 to 31 December 2014 were identified from attendance codes, specified at the local level. Time series statistical methods were used to detect both regional and national trends. In total, 247 016 (178 709 males: 72.3%) violence-related attendances were identified. Estimated annual injury rate across England and Wales was 4.4/1000 population (95% CI 3.9 to 4.9); males 6.5/1000 (95% CI 5.6 to 7.2) and females 2.4/1000 (95% CI 2.1 to 2.6). On average, overall attendances decreased by 13.8% per year over the 5 years (95% CI -14.8 to -12.1). Attendances decreased significantly for both genders and all age groups (0-10, 11-17, 18-30, 31-50, 51+ years); declines were greatest among children and adolescents. Significant decreases in violence-related injury were found in all but two regions. Violence peaked in May and July. From an ED perspective, violence in England and Wales decreased substantially between 2010 and 2014, especially among children and adolescents. Violence prevention efforts should focus on regions with the highest injury rates and during the period May-July. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  2. People's Collection Wales: Online Access to the Heritage of Wales from Museums, Archives and Libraries

    Science.gov (United States)

    Tedd, Lucy A.

    2011-01-01

    Purpose: The People's Collection Wales aims to collect, interpret, distribute and discuss Wales' cultural heritage in an online environment. Individual users or local history societies are able to create their own digital collections, contribute relevant content, as well as access digital resources from heritage institutions. This paper aims to…

  3. Prospective Assessment of Virtual Screening Heuristics Derived Using a Novel Fusion Score.

    Science.gov (United States)

    Pertusi, Dante A; O'Donnell, Gregory; Homsher, Michelle F; Solly, Kelli; Patel, Amita; Stahler, Shannon L; Riley, Daniel; Finley, Michael F; Finger, Eleftheria N; Adam, Gregory C; Meng, Juncai; Bell, David J; Zuck, Paul D; Hudak, Edward M; Weber, Michael J; Nothstein, Jennifer E; Locco, Louis; Quinn, Carissa; Amoss, Adam; Squadroni, Brian; Hartnett, Michelle; Heo, Mee Ra; White, Tara; May, S Alex; Boots, Evelyn; Roberts, Kenneth; Cocchiarella, Patrick; Wolicki, Alex; Kreamer, Anthony; Kutchukian, Peter S; Wassermann, Anne Mai; Uebele, Victor N; Glick, Meir; Rusinko, Andrew; Culberson, J Christopher

    2017-09-01

    High-throughput screening (HTS) is a widespread method in early drug discovery for identifying promising chemical matter that modulates a target or phenotype of interest. Because HTS campaigns involve screening millions of compounds, it is often desirable to initiate screening with a subset of the full collection. Subsequently, virtual screening methods prioritize likely active compounds in the remaining collection in an iterative process. With this approach, orthogonal virtual screening methods are often applied, necessitating the prioritization of hits from different approaches. Here, we introduce a novel method of fusing these prioritizations and benchmark it prospectively on 17 screening campaigns using virtual screening methods in three descriptor spaces. We found that the fusion approach retrieves 15% to 65% more active chemical series than any single machine-learning method and that appropriately weighting contributions of similarity and machine-learning scoring techniques can increase enrichment by 1% to 19%. We also use fusion scoring to evaluate the tradeoff between screening more chemical matter initially in lieu of replicate samples to prevent false-positives and find that the former option leads to the retrieval of more active chemical series. These results represent guidelines that can increase the rate of identification of promising active compounds in future iterative screens.

  4. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications

    Science.gov (United States)

    Vardanyan, Ruben S; Hruby, Victor J

    2014-01-01

    Fentanyl and its analogs have been mainstays for the treatment of severe to moderate pain for many years. In this review, we outline the structural and corresponding synthetic strategies that have been used to understand the structure–biological activity relationship in fentanyl-related compounds and derivatives and their biological activity profiles. We discuss how changes in the scaffold structure can change biological and pharmacological activities. Finally, recent efforts to design and synthesize novel multivalent ligands that act as mu and delta opioid receptors and NK-1 receptors are discussed. PMID:24635521

  5. Anti-HIV therapy with AZT prodrugs: AZT phosphonate derivatives, current state and prospects.

    Science.gov (United States)

    Khandazhinskaya, Anastasiya; Matyugina, Elena; Shirokova, Elena

    2010-06-01

    AIDS, a disease caused by human immunodeficiency virus, was called 'plague of the twentieth century'. 3'-Azido-3'-deoxythymidine (AZT), the first compound approved for the treatment of HIV, is still a mandatory component of treatment schemes. However, its toxicity stimulated a search for new agents. This review presents the history and current state of the design of AZT prodrugs based on its phosphonate derivatives. Although every effort was made to include as many AZT structures bearing phosphonate residues and demonstrate the variety they offer, we also concentrated on the studies performed in our laboratory. Special attention was also paid to AZT 5'-H-phosphonate (phosphazide, Nikavir) approved in the Russian Federation as a drug for the prevention and treatment of HIV infection. The prodrug strategy applied to AZT phosphonate derivatives enriched chemistry, biology and medicine not only with new knowledge, methods and structures, but also with a new anti-HIV drug Nikavir. Currently, study of another phosphonate, AZT 5'-aminocarbonylphosphonate, is underway. Slow release of AZT following oral administration and penetration into cells, decreased toxicity and the lack of cumulative properties make the compounds of this group promising as extended-release forms of AZT.

  6. Potential for cadaveric organ retrieval in New South Wales.

    Science.gov (United States)

    Hibberd, A D; Pearson, I Y; McCosker, C J; Chapman, J R; Macdonald, G J; Thompson, J F; O'Connell, D L; Mohacsi, P J; McLoughlin, M P; Spratt, P M

    1992-05-23

    To measure the potential for cadaver organ retrieval in New South Wales and to determine the reasons for potential donors failing to become actual donors. Prospective audit of all patients dying in five hospitals in New South Wales between 1 December 1989 and 30 November 1990; quality assurance of the data by independent medical specialist and if disagreement by study committee. 2879 patients (100% of all deaths) yielding 364 patients with coma and 181 potential donors. Realistic medically suitable potential donor rate, missed potential donor rate, rate of potential donors with permission refused, donor rate, reasons for realistic medically suitable potential donors failing to become actual donors. 2879 deaths yielded 73 medically suitable potential donors, resulting in 19 actual donors, 30 missed potential donors, 19 potential donors with permission refused, and five in whom adequate resuscitation failed. The most common reason for a potential donor failing to become an actual donor was a decision by the senior medical practitioner to withdraw or not to institute ventilatory or haemodynamic support (26/73). The second major obstacle was refusal of permission by the next of kin (17/73). Assuming that the potential donor rate was that implied by the observed donor rate (13/million population/year) the projected missed potential donor rate was 9/million population/year (95% confidence interval 4 to 15) and the projected rate of potential donors with permission refused was 13/million population/year (95% confidence interval 5 to 22). Assuming that the rate of potential donors in the study hospitals was the same as in the other New South Wales hospitals, the projected donor rate for New South Wales was 18/million population/year (10 to 26); the projected missed potential donor rate was 15/million population/year (7 to 23); and the projected rate of potential donors with permission refused was 18/million population/year (10 to 27). The donor rate could be increased 70

  7. Empirically derived dietary patterns and risk of postmenopausal breast cancer in a large prospective cohort study.

    Science.gov (United States)

    Velie, Ellen M; Schairer, Catherine; Flood, Andrew; He, Jian-Ping; Khattree, Ravindra; Schatzkin, Arthur

    2005-12-01

    Inconsistent associations have been reported between diet and breast cancer. We prospectively examined the association between dietary patterns and postmenopausal breast cancer risk in a US-wide cohort study. Data were analyzed from 40 559 women who completed a self-administered 61-item Block food-frequency questionnaire in the Breast Cancer Detection Demonstration Project, 1987-1998; 1868 of those women developed breast cancer. Dietary patterns were defined by using principal components factor analysis. Cox proportional hazard regression was used to assess breast cancer risk. Three major dietary patterns emerged: vegetable-fish/poultry-fruit, beef/pork-starch, and traditional southern. The vegetable-fish/poultry-fruit pattern was associated with higher education than were the other patterns, but was similar in nutrient intake to the traditional southern pattern. After adjustment for confounders, there was no significant association between the vegetable-fish/poultry-fruit and beef/pork-starch patterns and breast cancer. The traditional southern pattern, however, was associated with a nonsignificantly reduced breast cancer risk among all cases (in situ and invasive) that was significant for invasive breast cancer (relative hazard = 0.78; 95% CI = 0.65, 0.95; P for trend = 0.003). This diet was also associated with a reduced risk in women without a family history of breast cancer (P = 0.05), who were underweight or normal weight [body mass index (in kg/m(2)) dressing intake, and possibly cabbage. The traditional southern diet or its components are associated with a reduced risk of invasive breast cancer in postmenopausal women.

  8. Placenta and Placental Derivatives in Regenerative Therapies: Experimental Studies, History, and Prospects

    Directory of Open Access Journals (Sweden)

    Olena Pogozhykh

    2018-01-01

    Full Text Available Placental structures, capable to persist in a genetically foreign organism, are a natural model of allogeneic engraftment carrying a number of distinctive properties. In this review, the main features of the placenta and its derivatives such as structure, cellular composition, immunological and endocrine aspects, and the ability to invasion and deportation are discussed. These features are considered from a perspective that determines the placental material as a unique source for regenerative cell therapies and a lesson for immunological tolerance. A historical overview of clinical applications of placental extracts, cells, and tissue components is described. Empirically accumulated data are summarized and compared with modern research. Furthermore, we define scopes and outlooks of application of placental cells and tissues in the rapidly progressing field of regenerative medicine.

  9. Placenta and Placental Derivatives in Regenerative Therapies: Experimental Studies, History, and Prospects.

    Science.gov (United States)

    Pogozhykh, Olena; Prokopyuk, Volodymyr; Figueiredo, Constança; Pogozhykh, Denys

    2018-01-01

    Placental structures, capable to persist in a genetically foreign organism, are a natural model of allogeneic engraftment carrying a number of distinctive properties. In this review, the main features of the placenta and its derivatives such as structure, cellular composition, immunological and endocrine aspects, and the ability to invasion and deportation are discussed. These features are considered from a perspective that determines the placental material as a unique source for regenerative cell therapies and a lesson for immunological tolerance. A historical overview of clinical applications of placental extracts, cells, and tissue components is described. Empirically accumulated data are summarized and compared with modern research. Furthermore, we define scopes and outlooks of application of placental cells and tissues in the rapidly progressing field of regenerative medicine.

  10. Support sought for petition on safer staffing levels in Wales.

    Science.gov (United States)

    2014-11-01

    RCN WALES is urging the public to sign an e-petition supporting draft legislation on safe staffing. The petition calls for support for the Safe Nursing Staffing Levels (Wales) Bill, drawn up by Welsh Liberal Democrat leader Kirsty Williams.

  11. Rum Corps to IXL: Services to Pastoralists and Farmers in New South Wales

    OpenAIRE

    Davidson, Bruce Robinson

    1990-01-01

    By 1850, New South Wales (NSW) appeared to have entered a period of long term economic stability which was almost entirely dependent on the production of fine wool. The prospects of such a future vanished with the discovery of large quantities of alluvial gold in 1851. The population of the colony almost doubled, increasing from 179,000 in 1851 to 351,000 in 1861 (Vamplew 1987, p. 26).

  12. Assessing the accuracy of algorithm-derived cardiorespiratory fitness in surgical patients: a prospective cohort study.

    Science.gov (United States)

    Hammal, Fadi; Quaife, Tanis; Purich, Kieran; Haennel, Robert; Gragasin, Ferrante S; Martin-Feeney, Daniella San; Finegan, Barry A

    2017-04-01

    To determine if a non-exercise algorithm-derived assessment of cardiorespiratory fitness (CRF A ) accurately predicted estimated values obtained using a six-minute walk test (CRF 6MWD ) and the Duke Activity Status Index (CRF DASI ). Following research ethics board approval, an observational cohort study was conducted in selected, consenting patients undergoing elective surgery. Participants completed questionnaires assessing their self-reported exercise capacity. Their height, weight, waist circumference, and vital signs were measured. A six-minute walk test was performed twice with a 45-min rest interval between tests. The correlation between CRF A and both CRF 6MWD and CRF DASI was determined. Two hundred forty-two participants were included. Mean age was 62 (range 45-88 yr); 150 (62%) were male, 87 (36%) self-reported walking or jogging > 16 km per week, and 49 (20%) were current smokers. The CRF A and CRF 6MWD were highly correlated (Pearson r = 0.878; P 427 m in the six-minute walk test, CRF A , CRF 6MWD , and CRF DASI were equivalent. A non-exercise algorithm can estimate cardiorespiratory fitness in patients presenting for elective surgery. The variables required to compute CRF A can be obtained in a clinic setting without the need to engage in formal exercise testing. Further evaluation of CRF A as a predictor of long-term outcome in patients is warranted.

  13. Enteromorpha intestinalis Derived Seaweed Liquid Fertilizers as Prospective Biostimulant for Glycine max

    Directory of Open Access Journals (Sweden)

    Chetna Mathur

    2015-12-01

    Full Text Available ABSTRACT In the present study, the potential of seaweed liquid fertilizer (SLF of marine algae Enteromorpha intestinalis was evaluated for its effect on seed germination, yield, biochemical parameters and pigment characteristics of Glycine maxE. intestinalis was collected form Mandapam coast of Gulf of Mannar, Tamil Nadu, and the dried seaweeds were used for the preparation of SLF. G. max seeds were germinated with four different concentrations (20, 40, 60, and 100% of SLF; its growth and yield parameters were evaluated and compared with chemical fertilizer and control. The morphological and bio-chemical parameters such as seed germination (100%, root (6.6cm and shoot length (5.4 cm, carbohydrates (0.098 mg/g, protein (0.56 mg/g, pigment (0.444 mg/g chl a; 1.073 mg/g chl b; 3.70 mg/g carotenoids of the plant was found maximum at a concentration of 60% SLF. The phenol content (3.25 mg/g was maximum in 40% SLF. The GC-MS analysis of SLF revealed the presence of notable benzoic compounds involved in plant growth promotion. Results showed thatE. intestinalis derived SLF was potential biostimulant forG. max. Thus, marine algae based fertilizer could be an effective and alternate to the chemical fertilizers emphasizing the need for systematic evaluation programme for SLF on various crops.

  14. 76 FR 2646 - Prince of Wales Resource Advisory Committee

    Science.gov (United States)

    2011-01-14

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince of Wales Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince of Wales Resource Advisory Committee... Ranger District, 504 9th Street, Craig, Alaska. Send written comments to Prince of Wales Resource...

  15. 75 FR 65447 - Prince of Wales Resource Advisory Committee

    Science.gov (United States)

    2010-10-25

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince of Wales Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince of Wales Resource Advisory Committee... Ranger District 504 9th Street, Craig, Alaska. Send written comments to Prince of Wales Resource Advisory...

  16. 77 FR 50081 - Prince of Wales Resource Advisory Committee

    Science.gov (United States)

    2012-08-20

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince of Wales Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince of Wales Resource Advisory Committee... be sent to Prince of Wales RAC c/o District Ranger P.O. Box 500 Craig, AK 99921, or by email to...

  17. 75 FR 37753 - Prince of Wales Resource Advisory Committee

    Science.gov (United States)

    2010-06-30

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince of Wales Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince of Wales Resource Advisory Committee... Ranger District, 504 9th Street, Craig, Alaska. Send written comments to Prince of Wales Resource...

  18. 76 FR 12933 - Prince of Wales Resource Advisory Committee

    Science.gov (United States)

    2011-03-09

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince of Wales Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince of Wales Resource Advisory Committee... Bay Ranger District 1312 Federal Way Thorne Bay, Alaska. Send written comments to Prince of Wales...

  19. 76 FR 28416 - Prince of Wales Resource Advisory Committee

    Science.gov (United States)

    2011-05-17

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince of Wales Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince of Wales Resource Advisory Committee... Prince of Wales RAC c/o District Ranger P.O. Box 500 Craig, AK 99921, or by e-mail to [email protected

  20. 75 FR 75662 - Prince of Wales Resource Advisory Committee

    Science.gov (United States)

    2010-12-06

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince of Wales Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince of Wales Resource Advisory Committee... Ferry Terminal 110 Stikine Way, Coffman Cove, Alaska. Send written comments to Prince of Wales Resource...

  1. 76 FR 24852 - Prince of Wales Resource Advisory Committee

    Science.gov (United States)

    2011-05-03

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince of Wales Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince of Wales Resource Advisory Committee... for oral comments must be sent to Prince of Wales RAC c/o District Ranger P.O. Box 500 Craig, AK 99921...

  2. 76 FR 45504 - Prince of Wales Resource Advisory Committee

    Science.gov (United States)

    2011-07-29

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince of Wales Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince of Wales Resource Advisory Committee.... Written comments and requests for time for oral comments must be sent to Prince of Wales RAC c/o District...

  3. 77 FR 58095 - Prince of Wales Resource Advisory Committee

    Science.gov (United States)

    2012-09-19

    ... DEPARTMENT OF AGRICULTURE Forest Service Prince of Wales Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince of Wales Resource Advisory Committee... must be sent to Prince of Wales RAC c/o District Ranger P.O. Box 500 Craig, AK 99921, or by email to...

  4. Translanguaging in Bilingual Schools in Wales

    Science.gov (United States)

    Jones, Bryn

    2017-01-01

    This article examines the use of translanguaging as a pedagogical tool to support learning within bilingual classrooms in schools in Wales. Translanguaging is considered within non-pedagogic and pedagogic school contexts; hence, a distinction is made between universal and classroom translanguaging. Translanguaging has evoked debate surrounding the…

  5. Radionuclides around nuclear sites in England and Wales

    International Nuclear Information System (INIS)

    Sanchez, A.L.; Horrill, A.D.; Singleton, D.L.; Leonard, D.R.P.

    1996-01-01

    Environmental releases of low levels of radioactivity can occur as a consequence of normal operations at nuclear facilities. In England and Wales, the impact of gaseous discharges on the terrestrial environment is monitored routinely by the site operators as well as by Food Science Division of the Ministry of Agriculture, Fisheries and Food. The terrestrial surveillance programme carried out by MAFF Food Science concentrates on agricultural produce to provide assessments of doses to members of the population derived from the consumption of terrestrial foodstuffs. We present here the results of a survey, undertaken in 1993 to supplement the monitoring data of MAFF, of artificial radioactive contamination around eighteen nuclear establishments in England and Wales. Grass and soil samples were used as indicators of environmental contamination at these sites for the radionuclides 137 Cs, 90 Sr, 239+240 Pu and 241 Am. When compared to estimated background radionuclide concentrations close to each site, these data reveal that four of the 18 sites have contributed measurable increases to both the 137 Cs and 239+240 Pu inventory within 500 m outside the boundary fence. Two additional sites showed slight increases above the expected background soil levels of 239+240 Pu

  6. Prospectively Isolated Human Bone Marrow Cell-Derived MSCs Support Primitive Human CD34-Negative Hematopoietic Stem Cells.

    Science.gov (United States)

    Matsuoka, Yoshikazu; Nakatsuka, Ryusuke; Sumide, Keisuke; Kawamura, Hiroshi; Takahashi, Masaya; Fujioka, Tatsuya; Uemura, Yasushi; Asano, Hiroaki; Sasaki, Yutaka; Inoue, Masami; Ogawa, Hiroyasu; Takahashi, Takayuki; Hino, Masayuki; Sonoda, Yoshiaki

    2015-05-01

    Hematopoietic stem cells (HSCs) are maintained in a specialized bone marrow (BM) niche, which consists of osteoblasts, endothelial cells, and a variety of mesenchymal stem/stromal cells (MSCs). However, precisely what types of MSCs support human HSCs in the BM remain to be elucidated because of their heterogeneity. In this study, we succeeded in prospectively isolating/establishing three types of MSCs from human BM-derived lineage- and CD45-negative cells, according to their cell surface expression of CD271 and stage-specific embryonic antigen (SSEA)-4. Among them, the MSCs established from the Lineage(-) CD45(-) CD271(+) SSEA-4(+) fraction (DP MSC) could differentiate into osteoblasts and chondrocytes, but they lacked adipogenic differentiation potential. The DP MSCs expressed significantly higher levels of well-characterized HSC-supportive genes, including IGF-2, Wnt3a, Jagged1, TGFβ3, nestin, CXCL12, and Foxc1, compared with other MSCs. Interestingly, these osteo-chondrogenic DP MSCs possessed the ability to support cord blood-derived primitive human CD34-negative severe combined immunodeficiency-repopulating cells. The HSC-supportive actions of DP MSCs were partially carried out by soluble factors, including IGF-2, Wnt3a, and Jagged1. Moreover, contact between DP MSCs and CD34-positive (CD34(+) ) as well as CD34-negative (CD34(-) ) HSCs was important for the support/maintenance of the CD34(+/-) HSCs in vitro. These data suggest that DP MSCs might play an important role in the maintenance of human primitive HSCs in the BM niche. Therefore, the establishment of DP MSCs provides a new tool for the elucidation of the human HSC/niche interaction in vitro as well as in vivo. © 2014 AlphaMed Press.

  7. REE enrichment in granite-derived regolith deposits of the southeast United States: Prospective source rocks and accumulation processes

    Science.gov (United States)

    Foley, Nora K.; Ayuso, Robert A.; Simandl, G.J.; Neetz, M.

    2015-01-01

    The Southeastern United States contains numerous anorogenic, or A-type, granites, which constitute promising source rocks for REE-enriched ion adsorption clay deposits due to their inherently high concentrations of REE. These granites have undergone a long history of chemical weathering, resulting in thick granite-derived regoliths, akin to those of South China, which supply virtually all heavy REE and Y, and a significant portion of light REE to global markets. Detailed comparisons of granite regolith profiles formed on the Stewartsville and Striped Rock plutons, and the Robertson River batholith (Virginia) indicate that REE are mobile and can attain grades comparable to those of deposits currently mined in China. A REE-enriched parent, either A-type or I-type (highly fractionated igneous type) granite, is thought to be critical for generating the high concentrations of REE in regolith profiles. One prominent feature we recognize in many granites and mineralized regoliths is the tetrad behaviour displayed in REE chondrite-normalized patterns. Tetrad patterns in granite and regolith result from processes that promote the redistribution, enrichment, and fractionation of REE, such as late- to post- magmatic alteration of granite and silicate hydrolysis in the regolith. Thus, REE patterns showing tetrad effects may be a key for discriminating highly prospective source rocks and regoliths with potential for REE ion adsorption clay deposits.

  8. Magnetic tagging of cell-derived microparticles: new prospects for imaging and manipulation of these mediators of biological information.

    Science.gov (United States)

    Vats, Nidhi; Wilhelm, Claire; Rautou, Pierre-Emmanuel; Poirier-Quinot, Marie; Péchoux, Christine; Devue, Cécile; Boulanger, Chantal M; Gazeau, Florence

    2010-07-01

    Submicron membrane fragments termed microparticles (MPs), which are released by apoptotic or activated cells, are newly considered as vectors of biological information and actors of pathology development. We propose the tagging of MPs with magnetic nanoparticles as a new approach allowing imaging, manipulation and targeting of cell-derived MPs. MPs generated in vitro from human endothelial cells or isolated from atherosclerotic plaques were labeled using citrate-coated 8 nm iron-oxide nanoparticles. MPs were tagged with magnetic nanoparticles on their surface and detected as Annexin-V positive by flow cytometry. Labeled MPs could be mobilized, isolated and manipulated at a distance in a magnetic field gradient. Magnetic mobility of labeled MPs was quantified by micromagnetophoresis. Interactions of labeled MPs with endothelial cells could be triggered and modulated by magnetic guidance. Nanoparticles served as tracers at different scales: at the subcellular level by electron microscopy, at the cellular level by histology and at the macroscopic level by MRI. Magnetic labeling of biogenic MPs opens new prospects for noninvasive monitoring and distal manipulations of these biological effectors.

  9. Prospective Teachers' Reactions to "Right-or-Wrong" Tasks: The Case of Derivatives of Absolute Value Functions

    Science.gov (United States)

    Tsamir, Pessia; Rasslan, Shaker; Dreyfus, Tommy

    2006-01-01

    This paper illustrates the role of a "Thinking-about-Derivatives" task in identifying learners' derivative conceptions and for promoting their critical thinking about derivatives of absolute value functions. The task included three parts: "Define" the derivative of a function f(x) at x = x[subscript 0], "Solve-if-Possible" the derivative of f(x) =…

  10. Life expectancy estimation in small administrative areas with non-uniform population sizes: application to Australian New South Wales local government areas

    OpenAIRE

    Stephens, Alexandre S; Purdie, Stuart; Yang, Baohui; Moore, Helen

    2013-01-01

    Objective To determine a practical approach for deriving life expectancy estimates in Australian New South Wales local government areas which display a large diversity in population sizes. Design Population-based study utilising mortality and estimated residential population data. Setting 153 local government areas in New South Wales, Australia. Outcome measures Key performance measures of Chiang II, Silcocks, adjusted Chiang II and Bayesian random effects model methodologies of life expectan...

  11. Radon atlas of England and Wales

    International Nuclear Information System (INIS)

    Green, B.M.R.; Miles, J.C.H.; Bradley, E.J.; Rees, D.M.

    2002-01-01

    This new report brings together and updates the information in three earlier reports on radon levels in English and Welsh homes. In particular, data from measurements in over 400,000 homes in England and Wales are presented in tabular format. The tables give the data by various administrative divisions, down to electoral wards for Cornwall, Devon and Somerset and council areas elsewhere and to sector level of the postcode system. The radon probability maps are based on the national grid system and show significantly more locational detail than the previous publications, an extra division in the probability banding to coincide with current Government initiatives on radon in England and, in southwest England, more detailed probability mapping than before - by 1 km grid squares in place of the 5 km grid squares used in Wales and the rest of England. (author)

  12. Various Stone-Wales defects in phagraphene

    Science.gov (United States)

    Openov, L. A.; Podlivaev, A. I.

    2016-08-01

    Various Stone-Wales defects in phagraphene, which is a graphene allotrope, predicted recently are studied in terms of the nonorthogonal tight-binding model. The energies of the defect formation and the heights of energy barriers preventing the formation and annealing of the defects are found. Corresponding frequency factors in the Arrhenius formula are calculated. The evolution of the defect structure is studied in the real-time mode using the molecular dynamics method.

  13. Aetiology of hyperthyroidism in Canada and Wales.

    OpenAIRE

    Williams, I; Ankrett, V O; Lazarus, J H; Volpe, R

    1983-01-01

    A retrospective, comparative review of 100 consecutive new outpatients presenting with hyperthyroidism in Cardiff, South Wales, and in Toronto, Canada, was performed. The aim was to quantify the causes of hyperthyroidism with particular emphasis on the prevalence of viral thyroiditis and "silent" thyroiditis. The proportional morbidity of Graves' disease (approximately 70%) was similar in the two groups. Toxic multinodular goitre and toxic adenoma (Plummers' disease) occurred significantly mo...

  14. Empirically Derived Dehydration Scoring and Decision Tree Models for Children With Diarrhea: Assessment and Internal Validation in a Prospective Cohort Study in Dhaka, Bangladesh

    OpenAIRE

    Levine, Adam C; Glavis-Bloom, Justin; Modi, Payal; Nasrin, Sabiha; Rege, Soham; Chu, Chieh; Schmid, Christopher H; Alam, Nur H

    2015-01-01

    Introduction: Diarrhea remains one of the most common and most deadly conditions affecting children worldwide. Accurately assessing dehydration status is critical to determining treatment course, yet no clinical diagnostic models for dehydration have been empirically derived and validated for use in resource-limited settings. Methods: In the Dehydration: Assessing Kids Accurately (DHAKA) prospective cohort study, a random sample of children under 5 with acute diarrhea was enrolled between Feb...

  15. Early Jurassic allotherians from South Wales (United Kingdom

    Directory of Open Access Journals (Sweden)

    W. A. Clemens

    2007-02-01

    Full Text Available Fossils from two fissure fillings in Pant Quarry (designated Pant 4 and Pant 5, South Wales, United Kingdom, probably of Early Jurassic age document a taxonomically diverse vertebrate fauna, the Morganucodon-sphenodont fauna, composed of several kinds of reptiles, non-mammalian synapsids, and mammals. Six isolated molariform teeth from Pant 4 and 5 fissures clearly record the presence of Thomasia (Mammalia, Allotheria, Haramiyidae, a genus previously known only from purported Late Triassic faunas of southwestern England, France, Belgium, Luxemburg, Germany, and Switzerland. Small morphological differences from teeth in the larger English and continental European samples warrant identification of the Welsh material as Thomasia cf. moorei. The highly derived morphology of an isolated molariform tooth from Pant 5 fissure indicates the presence of another, possibly allotherian, taxon. Fossilien aus zwei wahrscheinlich unterjurassischen Spaltenfüllungen (Pant 4 und Pant 5 im Steinbruch Pant in Süd-Wales dokumentieren eine taxonomisch diverse Wirbeltierfauna. Diese Morganucodon-Sphenodontiden-Fauna besteht aus verschiedenen Formen von Reptilien, Synapsiden und Säugetieren. Sechs isolierte molariforme Zähne aus den Spaltenfüllungen Pant 4 und Pant 5 belegen eindeutig das Vorkommen von Thomasia (Mammalia, Allotheria, Haramiyidae, einer bisher nur aus vermutlich obertriassischen Faunen Südwest-Englands, Frankreichs, Belgiens, Luxemburgs, Deutschlands und der Schweiz bekannten Gattung. Geringe morphologische Unterschiede zu dem umfangreicheren Material aus England und Kontinental-Europa sprechen für die Identifikation des neuen Materials als Thomasia cf. moorei. Die stark abgeleitete Morphologie eines isolierten molariformen Zahnes aus der Spalte Pant 5 belegt das Vorkommen eines anderen Taxons, das möglicherweise auch den Allotheria zuzuordnen ist. doi:10.1002/mmng.200600018

  16. The nuclear electricity generating industry in England and Wales post-privatisation

    International Nuclear Information System (INIS)

    Johnson, C.B.

    1992-01-01

    This paper presents an overview of the new legal framework within which the nuclear generating industry has operated in England and Wales since 31 March 1990. It describes the formation of Nuclear Electric plc and the licensing arrangements, including the various obligations which have been placed upon Nuclear Electric by virtue of its Generation Licence. The impact of competition law is outlined, together with the commercial arrangements including electricity pooling and some of the other more important agreements which Nuclear Electric has entered into. Finally, the Paper discusses some of the constraints under which Nuclear Electric operates, and summarises Government policy towards nuclear power and its future prospects in the United Kingdom. (author)

  17. Clinical application prospect of umbilical cord-derived mesenchymal stem cells on clearance of advanced glycation end products through autophagy on diabetic wound.

    Science.gov (United States)

    Han, Yanfu; Sun, Tianjun; Tao, Ran; Han, Yanqing; Liu, Jing

    2017-03-24

    Nowadays, wound healing delay due to diabetes is considered to be closely related to the accumulation of advanced glycation end products (AGEs). Although mesenchymal stem cells (MSCs) exhibit positive effects on diabetic wound healing, related mechanisms are still not fully elucidated. It has been reported that MSCs can improve the activity of autophagy in injured tissues, thereby playing an important role in wound healing. The autophagy induced by MSCs may be beneficial to diabetic wound healing via removing AGEs, which provide new ideas for clinical treatment of diabetic wounds with the potential of broad application prospects. In this study, the current research situation and application prospect of umbilical cord-derived MSCs on the clearance of AGEs in diabetic wound were reviewed.

  18. 78 FR 70955 - Prospective Grant of Exclusive Patent License: GMCSF-BclxL-Derived Chimeric Therapeutics for Use...

    Science.gov (United States)

    2013-11-27

    ... Exclusive Patent License: GMCSF-BclxL- Derived Chimeric Therapeutics for Use in Treatment of Cancer...-BclxL-derived chimeric therapeutics and immunotherapeutics, alone or in combination, for restoring...: [email protected] . SUPPLEMENTARY INFORMATION: The subject invention is to a chimeric protein...

  19. Landslide research in the South Wales coalfield

    International Nuclear Information System (INIS)

    Bentley, S.P.; Siddle, H.J.

    1996-01-01

    The areal density of landslides in the coalfield of South Wales is one of the highest in the UK. During the past 100 years landsliding has had considerable impact, causing structural damage and loss of life. Most of the landslides were initiated under periglacial conditions but many became reactivated due to the activities of man, particularly, during the late 19th century when widespread urban and industrial development commenced in the Welsh valleys. A number of the area's larger landslides are first-time slides which occurred during the past 100 years. This paper sets out to chart the history of landslide research in the coalfield, which began through work by mining engineers. 47 refs., 6 figs., 2 tabs

  20. Unothering" Wales. Domestication as a tourist marketing strategy

    Directory of Open Access Journals (Sweden)

    Prieto Arranz, José Igor

    2004-01-01

    Full Text Available Tourists in Wales are overwhelmingly British and its national tourist organisation, Wales Tourist Board, although certainly attempting to widen its share of foreign visitors, does pay special attention to those promotional materials designed to target the domestic British readership. Such award-winning materials will be analysed in the present work, which places special emphasis on their two main features: on the one hand, their embedded intertextual nature; on the other, the obvious taming or domestication of Welshness. As a result, Wales is turned into a "gratifyingly dissimilar", even perfected version of England, mostly catering for the potential English tourist

  1. Long-term trends of men's co-residence with children in England and Wales

    Directory of Open Access Journals (Sweden)

    Ursula Henz

    2014-03-01

    Full Text Available Background: Increasing numbers of childless men as well as fathers with reduced or no contact with their children have sparked concern about an erosion of fatherhood. Although the general trend is undisputed, claims about men's decreasing family involvement lack a sound empirical basis that enables comparisons between countries and sub-groups of society. Objective: This study derives long-term trends in father-child co-residence over the life course in England and Wales, and provides comparisons of these trends by level of education and ethnic origin. Methods: The paper calculates shares of father-child co-residence from the National Statistics Longitudinal Study (LS and the British Labour-Force Surveys (LFS. Results: There has been a decline of father-child co-residence in England and Wales for men in their thirties, an even greater decline for men in their twenties, and a small increase in the shares of father-child co-residence at higher ages. The trends for different educational groups were similar, but men with a degree had particularly low rates of father-child co-residence at younger ages, and relatively high ones at older ages. Neither less-educated men, nor men from Black-Caribbean and Black-African origins showed rates of father-child co-residence as low as one might have expected. Conclusions: The steady decline of father-child co-residence among men born between 1930 and 1979 in England and Wales lends support to claims about an erosion of fatherhood. However, it is unwarranted to generalize findings from other countries about particularly low levels of father-child co-residence among less-educated men to men in England and Wales.

  2. Derivation and validation of two decision instruments for selective chest CT in blunt trauma: a multicenter prospective observational study (NEXUS Chest CT).

    Science.gov (United States)

    Rodriguez, Robert M; Langdorf, Mark I; Nishijima, Daniel; Baumann, Brigitte M; Hendey, Gregory W; Medak, Anthony J; Raja, Ali S; Allen, Isabel E; Mower, William R

    2015-10-01

    Unnecessary diagnostic imaging leads to higher costs, longer emergency department stays, and increased patient exposure to ionizing radiation. We sought to prospectively derive and validate two decision instruments (DIs) for selective chest computed tomography (CT) in adult blunt trauma patients. From September 2011 to May 2014, we prospectively enrolled blunt trauma patients over 14 y of age presenting to eight US, urban level 1 trauma centers in this observational study. During the derivation phase, physicians recorded the presence or absence of 14 clinical criteria before viewing chest imaging results. We determined injury outcomes by CT radiology readings and categorized injuries as major or minor according to an expert-panel-derived clinical classification scheme. We then employed recursive partitioning to derive two DIs: Chest CT-All maximized sensitivity for all injuries, and Chest CT-Major maximized sensitivity for only major thoracic injuries (while increasing specificity). In the validation phase, we employed similar methodology to prospectively test the performance of both DIs. We enrolled 11,477 patients-6,002 patients in the derivation phase and 5,475 patients in the validation phase. The derived Chest CT-All DI consisted of (1) abnormal chest X-ray, (2) rapid deceleration mechanism, (3) distracting injury, (4) chest wall tenderness, (5) sternal tenderness, (6) thoracic spine tenderness, and (7) scapular tenderness. The Chest CT-Major DI had the same criteria without rapid deceleration mechanism. In the validation phase, Chest CT-All had a sensitivity of 99.2% (95% CI 95.4%-100%), a specificity of 20.8% (95% CI 19.2%-22.4%), and a negative predictive value (NPV) of 99.8% (95% CI 98.9%-100%) for major injury, and a sensitivity of 95.4% (95% CI 93.6%-96.9%), a specificity of 25.5% (95% CI 23.5%-27.5%), and a NPV of 93.9% (95% CI 91.5%-95.8%) for either major or minor injury. Chest CT-Major had a sensitivity of 99.2% (95% CI 95.4%-100%), a specificity of

  3. Prediction of shale prospectivity from seismically-derived reservoir and completion qualities: Application to a shale-gas field, Horn River Basin, Canada

    Science.gov (United States)

    Mo, Cheol Hoon; Lee, Gwang H.; Jeoung, Taek Ju; Ko, Kyung Nam; Kim, Ki Soo; Park, Kyung-sick; Shin, Chang Hoon

    2018-04-01

    Prospective shale plays require a combination of good reservoir and completion qualities. Total organic carbon (TOC) is an important reservoir quality and brittleness is the most critical condition for completion quality. We analyzed seismically-derived brittleness and TOC to investigate the prospectivity of the Horn River Group shale (the Muskwa, Otter Park, Evie shales) of a shale-gas field in the western Horn River Basin, British Columbia, Canada. We used the λρ-μρ brittleness template, constructed from the mineralogy-based brittleness index (MBI) and elastic logs from two wells, to convert the λρ and μρ volumes from prestack seismic inversion to the volume for the brittleness petrotypes (most brittle, intermediate, and least brittle). The probability maps of the most brittle petrotype for the three shales were generated from Bayesian classification, based on the λρ-μρ template. The relationship between TOC and P-wave and S-wave velocity ratio (VP/VS) at the wells allowed the conversion of the VP/VS volume from prestack inversion to the TOC volume, which in turn was used to construct the TOC maps for the three shales. Increased TOC is correlated with high brittleness, contrasting with the commonly-held understanding. Therefore, the prospectivity of the shales in the study area can be represented by high brittleness and increased TOC. We propose a shale prospectivity index (SPI), computed by the arithmetic average of the normalized probability of the most brittle petrotype and the normalized TOC. The higher SPI corresponds to higher production rates in the Muskwa and Evie shales. The areas of the highest SPI have not been fully tested. The future drilling should be focused on these areas to increase the economic viability of the field.

  4. A Multi-Center Prospective Derivation and Validation of a Clinical Prediction Tool for Severe Clostridium difficile Infection.

    LENUS (Irish Health Repository)

    Na, Xi

    2015-04-23

    Prediction of severe clinical outcomes in Clostridium difficile infection (CDI) is important to inform management decisions for optimum patient care. Currently, treatment recommendations for CDI vary based on disease severity but validated methods to predict severe disease are lacking. The aim of the study was to derive and validate a clinical prediction tool for severe outcomes in CDI.

  5. Law and Order...and the Prince of Wales

    Science.gov (United States)

    Bernard, Thomas L.

    1970-01-01

    Brief historical account setting forth the manner of fusion of a number of races to become the British, and the significant part played by the very first Prince of Wales in initiating this process. (RJ)

  6. Topological anisotropy of stone-wales waves in graphenic fragments.

    Science.gov (United States)

    Ori, Ottorino; Cataldo, Franco; Putz, Mihai V

    2011-01-01

    Stone-Wales operators interchange four adjacent hexagons with two pentagon-heptagon 5|7 pairs that, graphically, may be iteratively propagated in the graphene layer, originating a new interesting structural defect called here Stone-Wales wave. By minimization, the Wiener index topological invariant evidences a marked anisotropy of the Stone-Wales defects that, topologically, are in fact preferably generated and propagated along the diagonal of the graphenic fragments, including carbon nanotubes and graphene nanoribbons. This peculiar edge-effect is shown in this paper having a predominant topological origin, leaving to future experimental investigations the task of verifying the occurrence in nature of wave-like defects similar to the ones proposed here. Graph-theoretical tools used in this paper for the generation and the propagation of the Stone-Wales defects waves are applicable to investigate isomeric modifications of chemical structures with various dimensionality like fullerenes, nanotubes, graphenic layers, schwarzites, zeolites.

  7. Patterns of hospital admission with epistaxis for 26,725 patients over an 18-year period in Wales, UK

    Science.gov (United States)

    Fishpool, SJC; Tomkinson, A

    2012-01-01

    INTRODUCTION Epistaxis is the one of the most common otorhinolaryngology emergencies. This study examined the age and sex distribution of all patients admitted with epistaxis to National Health Service (NHS) hospitals in Wales, UK, over a period of 18 years and 9 months. METHODS The Patient Episode Database for Wales was examined for all patient admissions with a diagnosis of epistaxis between April 1991 and December 2009. The age and sex of these patients was recorded and the proportion of the underlying population affected was calculated by comparing admission rates to the population data derived from the 1991 and 2001 national population censuses for Wales. RESULTS A total of 26,725 patients were admitted to NHS hospitals in Wales with epistaxis over the period studied. The proportion of the population admitted with epistaxis increased from the age of 40 onwards. For all ages except patients in the 10–14 years group, a higher proportion of the male population was admitted with epistaxis than the comparable female population. This discrepancy was most pronounced between the ages of 15 and 49 years, with the female-to-male ratio of hospital admissions with epistaxis being 0.55. These ages (15 and 49 years) approximate the average age of menarche and menopause respectively in the UK. CONCLUSIONS Women of menstrual age have fewer hospital admissions with epistaxis. This may be due to oestrogens providing protection to the nasal vasculature (as they do to other areas of the vascular tree). PMID:23131225

  8. Transport processes for Chernobyl-labelled sediments: preliminary evidence from upland mid-Wales

    International Nuclear Information System (INIS)

    Bonnett, P.J.P.; Leeks, G.J.L.; Cambray, R.S.

    1989-01-01

    The nuclear accident at Chernobyl in April 1986 resulted in a significant increase in the inventory of radiocaesium retained in the soil in many regions of the United Kingdom. The deposition of 134 Cs provides a convenient tool for the examination of erosional processes in upland systems. Detailed soil sampling has been undertaken within the Plynlimon experimental catchments to establish the pattern of deposition of Chernobyl-derived radionuclides. The preliminary results of a combined radiometric and mineral magnetic approach to the study of the transport of Chernobyl-labelled sediments and their source areas on these upland catchments in mid-Wales are described. (author)

  9. Prospecting for novel plant-derived molecules of Rauvolfia serpentina as inhibitors of Aldose Reductase, a potent drug target for diabetes and its complications.

    Directory of Open Access Journals (Sweden)

    Shivalika Pathania

    Full Text Available Aldose Reductase (AR is implicated in the development of secondary complications of diabetes, providing an interesting target for therapeutic intervention. Extracts of Rauvolfia serpentina, a medicinal plant endemic to the Himalayan mountain range, have been known to be effective in alleviating diabetes and its complications. In this study, we aim to prospect for novel plant-derived inhibitors from R. serpentina and to understand structural basis of their interactions. An extensive library of R. serpentina molecules was compiled and computationally screened for inhibitory action against AR. The stability of complexes, with docked leads, was verified using molecular dynamics simulations. Two structurally distinct plant-derived leads were identified as inhibitors: indobine and indobinine. Further, using these two leads as templates, 16 more leads were identified through ligand-based screening of their structural analogs, from a small molecules database. Thus, we obtained plant-derived indole alkaloids, and their structural analogs, as potential AR inhibitors from a manually curated dataset of R. serpentina molecules. Indole alkaloids reported herein, as a novel structural class unreported hitherto, may provide better insights for designing potential AR inhibitors with improved efficacy and fewer side effects.

  10. Prospecting for novel plant-derived molecules of Rauvolfia serpentina as inhibitors of Aldose Reductase, a potent drug target for diabetes and its complications.

    Science.gov (United States)

    Pathania, Shivalika; Randhawa, Vinay; Bagler, Ganesh

    2013-01-01

    Aldose Reductase (AR) is implicated in the development of secondary complications of diabetes, providing an interesting target for therapeutic intervention. Extracts of Rauvolfia serpentina, a medicinal plant endemic to the Himalayan mountain range, have been known to be effective in alleviating diabetes and its complications. In this study, we aim to prospect for novel plant-derived inhibitors from R. serpentina and to understand structural basis of their interactions. An extensive library of R. serpentina molecules was compiled and computationally screened for inhibitory action against AR. The stability of complexes, with docked leads, was verified using molecular dynamics simulations. Two structurally distinct plant-derived leads were identified as inhibitors: indobine and indobinine. Further, using these two leads as templates, 16 more leads were identified through ligand-based screening of their structural analogs, from a small molecules database. Thus, we obtained plant-derived indole alkaloids, and their structural analogs, as potential AR inhibitors from a manually curated dataset of R. serpentina molecules. Indole alkaloids reported herein, as a novel structural class unreported hitherto, may provide better insights for designing potential AR inhibitors with improved efficacy and fewer side effects.

  11. Online chilling effects in England and Wales

    Directory of Open Access Journals (Sweden)

    Judith Townend

    2014-04-01

    Full Text Available Open and free internet-based platforms are seen as an enabler of global free expression, releasing writers from commercial and space constraints. However, many are working without the assistance of an in-house lawyer, or other legal resources. This may lead to undue suppression of public interest material, with important implications for freedom of expression and the democratic function of media. Two online surveys among digital and online journalists in England and Wales in 2013 indicated that the majority of encounters with defamation and privacy law take place outside the courts, with few formally recorded legal actions. This was particularly evident in a sample of ‘hyperlocal’ and local community publishers. In light of the results, this paper calls for a reappraisal of overly simplistic judicial and media applications of the ‘chilling effect’ doctrine, in order to expose its subjectivities and complexities. Additionally, attention needs to be paid to global and cross-jurisdictional media-legal environments, in order to help develop better internet policy and legal frameworks for protecting legitimate expression.

  12. New South Wales' new electricity transmission authority

    International Nuclear Information System (INIS)

    Fahey, J.

    1995-01-01

    The latest milestone in electricity reform in NSW was the formation of a new statutory authority, the Electricity Transmission Authority (ETA), to take over and operate the transmission assets of Pacific Power, formerly the New South Wales Electricity Commission. The ETA will be operational from 1 February 1995, in time for the proposed commencement of a national electricity market on 1 July 1995. The forces of competition are being used to improve the efficiency of the industry, to empower consumers with greater choice and to open up new opportunities for private-sector participation in the industry. Potentially commercial activities such as coal mines have been separated from the operational arm of Pacific Power so that they have to compete with the private sector in supplying power stations. Significant reductions have been made in the price of electricity to reduce existing cross-subsidizations so that commercial and industrial customers gain the biggest benefits. The new ETA will pay dividends to the NSW government, as private companies pay dividends to their shareholders, and it will be subject to the federal tax-equivalent regime. 2 photos

  13. Bio-prospecting of soil Streptomyces and its bioassay-guided isolation of microbial derived auxin with antifungal properties.

    Science.gov (United States)

    Saravana Kumar, P; Yuvaraj, P; Gabrial Paulraj, M; Ignacimuthu, S; Abdullah Al-Dhabi, N

    2018-06-05

    The present study was aimed to isolate bioactive actinomycetes with antifungal properties. Twenty-seven distinct soil derived actinomycetes were investigated for their antifungal activities. Among these, one isolate exhibited significant antifungal activity. Phenotypic and 16s rRNA gene sequence analysis strongly suggested that the active isolate BG4 belonged to the genus Streptomyces. Further, the chemical investigation of the active extract resulted in the isolation of a major compound and it was structurally elucidated as phenyl acetic acid (PAA). PAA exhibited promising antifungal activity with 100% inhibition, ranging from 31.25 to 25μg/mL. It is to be noted that PAA is naturally occurring and biologically active auxin. In addition, it has also been hypothesized that phytohormone endorsing the source of soil-symbionts has similar pathways for synthesizing compounds and its congeners of host due to horizontal gene transfer. These findings demonstrate that microbially derived phytohormone can be used to treat fungal infections. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  14. Use of the SONET Score to Evaluate High Volume Emergency Department Overcrowding: A Prospective Derivation and Validation Study

    Directory of Open Access Journals (Sweden)

    Hao Wang

    2015-01-01

    Full Text Available Background. The accuracy and utility of current Emergency Department (ED crowding estimation tools remain uncertain in EDs with high annual volumes. We aimed at deriving a more accurate tool to evaluate overcrowding in a high volume ED setting and determine the association between ED overcrowding and patient care outcomes. Methods. A novel scoring tool (SONET: Severely overcrowded-Overcrowded-Not overcrowded Estimation Tool was developed and validated in two EDs with both annual volumes exceeding 100,000. Patient care outcomes including the number of left without being seen (LWBS patients, average length of ED stay, ED 72-hour returns, and mortality were compared under the different crowding statuses. Results. The total number of ED patients, the number of mechanically ventilated patients, and patient acuity levels were independent risk factors affecting ED overcrowding. SONET was derived and found to better differentiate severely overcrowded, overcrowded, and not overcrowded statuses with similar results validated externally. In addition, SONET scores correlated with increased length of ED stay, number of LWBS patients, and ED 72-hour returns. Conclusions. SONET might be a better fit to determine high volume ED overcrowding. ED overcrowding negatively impacts patient care operations and often produces poor patient perceptions of standardized care delivery.

  15. The Climate Change Consortium of Wales (C3W)

    Science.gov (United States)

    Hendry, K. R.; Reis, J.; Hall, I. R.

    2011-12-01

    In response to the complexity and multidisciplinary nature of climate change research, the Climate Change Consortium of Wales (C3W) was formed in 2009 by the Welsh universities of Aberystwyth, Bangor, Cardiff and Swansea. Initially funded by Welsh Government, through the Higher Education Funding Council for Wales, the Countryside Council for Wales and the universities, C3W aims to bring together climate change researchers from a wide range of disciplines to explore scientific and sociological drivers, impacts and implications at local, national and international scale. The specific aims are to i) improve our fundamental understanding of the causes, nature, timing and consequences of climate change on Planet Earth's environment and on humanity, and ii) to reconfigure climate research in Wales as a recognisable centre of excellence on the world stage. In addition to improving the infrastructure for climate change research, we aim to improve communication, networking, collaborative research, and multidisciplinary data assimilation within and between the Welsh universities, and other UK and international institutions. Furthermore, C3W aims to apply its research by actively contributing towards national policy development, business development and formal and informal education activities within and beyond Wales.

  16. Endogenous Prospect Theory

    OpenAIRE

    Schmidt, Ulrich; Zank, Horst

    2010-01-01

    In previous models of (cumulative) prospect theory reference-dependence of preferences is imposed beforehand and the location of the reference point is exogenously determined. This paper provides an axiomatization of a new specification of cumulative prospect theory, termed endogenous prospect theory, where reference-dependence is derived from preference conditions and a unique reference point arises endogenously.

  17. The decline of coal in the Valleys of South Wales. El declive del carbon. El caso de los Valles del Sur (1)

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    This paper was destined exclusively for the Spanish Mine Safety committee and originated in the UK office of EURACOM. It describes the bleak prospects for mining in south Wales. While in 1919 the area had 257,000 mineworkers, today fewer than 2,000 remain in the industry following the industrial recession affecting the country as a whole. The problem has further exacerbated the impoverished Welsh economy and has caused growing environmental and social problems. 2 figs.

  18. Molybdenum distributions and variability in drinking water from England and Wales.

    Science.gov (United States)

    Smedley, P L; Cooper, D M; Lapworth, D J

    2014-10-01

    An investigation has been carried out of molybdenum in drinking water from a selection of public supply sources and domestic taps across England and Wales. This was to assess concentrations in relation to the World Health Organization (WHO) health-based value for Mo in drinking water of 70 μg/l and the decision to remove the element from the list of formal guideline values. Samples of treated drinking water from 12 water supply works were monitored up to four times over an 18-month period, and 24 domestic taps were sampled from three of their supply areas. Significant (p  0.05) were detected. Tap water samples collected from three towns (North Wales, the English Midlands, and South East England) supplied uniquely by upland reservoir water, river water, and Chalk groundwater, respectively, also showed a remarkable uniformity in Mo concentrations at each location. Within each, the variability was very small between houses (old and new), between pre-flush and post-flush samples, and between the tap water and respective source water samples. The results indicate that water distribution pipework has a negligible effect on supplied tap water Mo concentrations. The findings contrast with those for Cu, Zn, Ni, Pb, and Cd, which showed significant differences (p water samples. In two pre-flush samples, concentrations of Ni or Pb were above drinking water limits, although in all cases, post-flush waters were compliant. The high concentrations, most likely derived from metal pipework in the domestic distribution system, accumulated during overnight stagnation. The concentrations of Mo observed in British drinking water, in all cases less than 2 μg/l, were more than an order of magnitude below the WHO health-based value and suggest that Mo is unlikely to pose a significant health or water supply problem in England and Wales.

  19. 33 CFR 334.1330 - Bering Strait, Alaska; naval restricted area off Cape Prince of Wales.

    Science.gov (United States)

    2010-07-01

    ... restricted area off Cape Prince of Wales. 334.1330 Section 334.1330 Navigation and Navigable Waters CORPS OF....1330 Bering Strait, Alaska; naval restricted area off Cape Prince of Wales. (a) The area. An area 2,000 feet wide extending from a point on Cape Prince of Wales marked by a triangular cable marker located...

  20. Empirically derived dietary patterns and incident type 2 diabetes mellitus: a systematic review and meta-analysis on prospective observational studies.

    Science.gov (United States)

    Maghsoudi, Zahra; Ghiasvand, Reza; Salehi-Abargouei, Amin

    2016-02-01

    To systematically review prospective cohort studies about the association between dietary patterns and type 2 diabetes mellitus (T2DM) incidence, and to quantify the effects using a meta-analysis. Databases such as PubMed, ISI Web of Science, SCOPUS and Google Scholar were searched up to 15 January 2015. Cohort studies which tried to examine the association between empirically derived dietary patterns and incident T2DM were selected. The relative risks (RR) and their 95 % confidence intervals for diabetes among participants with highest v. lowest adherence to derived dietary patterns were incorporated into meta-analysis using random-effects models. Ten studies (n 404 528) were enrolled in the systematic review and meta-analysis; our analysis revealed that adherence to the 'healthy' dietary patterns significantly reduced the risk of T2DM (RR=0·86; 95 % CI 0·82, 0·90), while the 'unhealthy' dietary patterns adversely affected diabetes risk (RR=1·30; 95 % CI 1·18, 1·43). Subgroup analysis showed that unhealthy dietary patterns in which foods with high phytochemical content were also loaded did not significantly increase T2DM risk (RR=1·06; 95 % CI 0·87, 1·30). 'Healthy' dietary patterns containing vegetables, fruits and whole grains can lower diabetes risk by 14 %. Consuming higher amounts of red and processed meats, high-fat dairy and refined grains in the context of 'unhealthy' dietary patterns will increase diabetes risk by 30 %; while including foods with high phytochemical content in these patterns can modify this effect.

  1. Derivation and Validation of a Biomarker-Based Clinical Algorithm to Rule Out Sepsis From Noninfectious Systemic Inflammatory Response Syndrome at Emergency Department Admission: A Multicenter Prospective Study.

    Science.gov (United States)

    Mearelli, Filippo; Fiotti, Nicola; Giansante, Carlo; Casarsa, Chiara; Orso, Daniele; De Helmersen, Marco; Altamura, Nicola; Ruscio, Maurizio; Castello, Luigi Mario; Colonetti, Efrem; Marino, Rossella; Barbati, Giulia; Bregnocchi, Andrea; Ronco, Claudio; Lupia, Enrico; Montrucchio, Giuseppe; Muiesan, Maria Lorenza; Di Somma, Salvatore; Avanzi, Gian Carlo; Biolo, Gianni

    2018-05-07

    To derive and validate a predictive algorithm integrating a nomogram-based prediction of the pretest probability of infection with a panel of serum biomarkers, which could robustly differentiate sepsis/septic shock from noninfectious systemic inflammatory response syndrome. Multicenter prospective study. At emergency department admission in five University hospitals. Nine-hundred forty-seven adults in inception cohort and 185 adults in validation cohort. None. A nomogram, including age, Sequential Organ Failure Assessment score, recent antimicrobial therapy, hyperthermia, leukocytosis, and high C-reactive protein values, was built in order to take data from 716 infected patients and 120 patients with noninfectious systemic inflammatory response syndrome to predict pretest probability of infection. Then, the best combination of procalcitonin, soluble phospholypase A2 group IIA, presepsin, soluble interleukin-2 receptor α, and soluble triggering receptor expressed on myeloid cell-1 was applied in order to categorize patients as "likely" or "unlikely" to be infected. The predictive algorithm required only procalcitonin backed up with soluble phospholypase A2 group IIA determined in 29% of the patients to rule out sepsis/septic shock with a negative predictive value of 93%. In a validation cohort of 158 patients, predictive algorithm reached 100% of negative predictive value requiring biomarker measurements in 18% of the population. We have developed and validated a high-performing, reproducible, and parsimonious algorithm to assist emergency department physicians in distinguishing sepsis/septic shock from noninfectious systemic inflammatory response syndrome.

  2. Embracing the UNCRC in Wales (UK): Policy, Pedagogy and Prejudices

    Science.gov (United States)

    Lyle, Sue

    2014-01-01

    Most countries are signatories to the United Nations Convention on the Rights of the Child (UNCRC). In 1999, the Government of Wales was devolved from the UK, and in 2011 the "Children and Young Persons Rights Measure" put the UNCRC as the basis of all its work. Any programme introduced in schools should therefore promote the UNCRC. To…

  3. Malleefowl conservation in New South Wales: a review

    NARCIS (Netherlands)

    Priddel, D.; Wheeler, R.

    1999-01-01

    Together with land clearance, grazing by stock and inappropriate fire regimes, predation by the introduced European red fox Vulpes vulpes (Linnaeus, 1758) has decimated populations of malleefowl Leipoa ocellata Gould, 1840. The decline of the malleefowl has been most pronounced in New South Wales,

  4. Zigzag graphene nanoribbon edge reconstruction with Stone-Wales defects

    DEFF Research Database (Denmark)

    Rodrigues, J. N. B.; Gonçalves, P. A. D; Rodrigues, N. F. G.

    2011-01-01

    In this paper, we study zigzag graphene nanoribbons with edges reconstructed with Stone-Wales defects, by means of an empirical (first-neighbor) tight-binding method, with parameters determined by ab initio calculations of very narrow ribbons. We explore the characteristics of the electronic band...

  5. The western arctic linkage experiment (WALE): overview and synthesis

    Science.gov (United States)

    A.D. McGuire; J. Walsh; J.S. Kimball; J.S. Clein; S.E. Euskirdhen; S. Drobot; U.C. Herzfeld; J. Maslanik; R.B. Lammers; M.A. Rawlins; C.J. Vorosmarty; T.S. Rupp; W. Wu; M. Calef

    2008-01-01

    The primary goal of the Western Arctic Linkage Experiment (WALE) was to better understand uncertainties of simulated hydrologic and ecosystem dynamics of the western Arctic in the context of 1) uncertainties in the data available to drive the models and 2) different approaches to simulating regional hydrology and ecosystem dynamics. Analyses of datasets on climate...

  6. Sunlight–derived vitamin D affects interleukin-4 level, T helper 2 serum cytokines, in patients with Graves’ disease: a prospective cohort study

    Directory of Open Access Journals (Sweden)

    Dyah Purnamasari

    2015-12-01

    Full Text Available Background: Graves’ disease (GD is the most common autoimmune disease leading to hyperthyroidism. The role of Th1/Th2 pathways balance in GD is still controversial. Vitamin D is reported to have an effect on those pathways. This study aims to examine the effect of sunlight exposure on vitamin D 25(OH level and Th1 and Th2 pathway-derived cytokines in GD patients. Methods: A prospective cohort study was conducted on 32 GD patients to compare the effect of sunlight exposure on vitamin D level and cytokines of Th1 and Th2 pathways between exposed and unexposed groups. Exposed group received sunlight exposure three times a week for 30 minutes each between 9–11 a.m for 1 month. Thyroid stimulating hormone (TSH, free thyroxin (fT4, vitamin D 25(OH, interferon-γ (IFN-γ and interleukin-4 (IL-4 serum levels, were investigated before and after one month of sunlight exposure. Paired t-test or Mann Whitney test were used to analyze the difference between exposed and unexposed GD groups before and after sun exposure.Results: One month of sunlight exposure increased vitamin D 25(OH level by 27.90% among exposed GD group (15.34 ng/mL to 19.62 ng/mL, p<0.001. Meanwhile, unexposed GD group’s vitamin D 25(OH level decreased from 20.48 ng/mL to 18.86 ng/mL (p<0.001. Increased vitamin D 25(OH level in exposed group was not accompanied by the increase of IL-4 level after sunlight exposure.Conclusion: Sunlight exposure increases vitamin D 25(OH serum level and may affect the level of IL-4, Th2 pathway-derived cytokine, in patients with GD. However, the role of sunlight-derived vitamin D on IFN-γ in GD patients can not be concluded in this study.

  7. Bondonic effects in group-IV honeycomb nanoribbons with Stone-Wales topological defects.

    Science.gov (United States)

    Putz, Mihai V; Ori, Ottorino

    2014-04-03

    This work advances the modeling of bondonic effects on graphenic and honeycomb structures, with an original two-fold generalization: (i) by employing the fourth order path integral bondonic formalism in considering the high order derivatives of the Wiener topological potential of those 1D systems; and (ii) by modeling a class of honeycomb defective structures starting from graphene, the carbon-based reference case, and then generalizing the treatment to Si (silicene), Ge (germanene), Sn (stannene) by using the fermionic two-degenerate statistical states function in terms of electronegativity. The honeycomb nanostructures present η-sized Stone-Wales topological defects, the isomeric dislocation dipoles originally called by authors Stone-Wales wave or SWw. For these defective nanoribbons the bondonic formalism foresees a specific phase-transition whose critical behavior shows typical bondonic fast critical time and bonding energies. The quantum transition of the ideal-to-defect structural transformations is fully described by computing the caloric capacities for nanostructures triggered by η-sized topological isomerisations. Present model may be easily applied to hetero-combinations of Group-IV elements like C-Si, C-Ge, C-Sn, Si-Ge, Si-Sn, Ge-Sn.

  8. Bondonic Effects in Group-IV Honeycomb Nanoribbons with Stone-Wales Topological Defects

    Directory of Open Access Journals (Sweden)

    Mihai V. Putz

    2014-04-01

    Full Text Available This work advances the modeling of bondonic effects on graphenic and honeycomb structures, with an original two-fold generalization: (i by employing the fourth order path integral bondonic formalism in considering the high order derivatives of the Wiener topological potential of those 1D systems; and (ii by modeling a class of honeycomb defective structures starting from graphene, the carbon-based reference case, and then generalizing the treatment to Si (silicene, Ge (germanene, Sn (stannene by using the fermionic two-degenerate statistical states function in terms of electronegativity. The honeycomb nanostructures present η-sized Stone-Wales topological defects, the isomeric dislocation dipoles originally called by authors Stone-Wales wave or SWw. For these defective nanoribbons the bondonic formalism foresees a specific phase-transition whose critical behavior shows typical bondonic fast critical time and bonding energies. The quantum transition of the ideal-to-defect structural transformations is fully described by computing the caloric capacities for nanostructures triggered by η-sized topological isomerisations. Present model may be easily applied to hetero-combinations of Group-IV elements like C-Si, C-Ge, C-Sn, Si-Ge, Si-Sn, Ge-Sn.

  9. Professional ideologies and the development of syringe exchange: Wales as a case study.

    Science.gov (United States)

    Keene, J M; Stimson, G V

    1997-12-01

    This paper is derived from an evaluative study of HIV prevention programs for drug injectors across Wales. It considers how different professional territories and ideologies, concepts of drug misuse and models of HIV prevention may influence policy development. The research involved monitoring the introduction and development of agency and community based syringe exchange schemes and initiatives taken by community pharmacists. Interviews with staff, managers and administrators, and descriptions of service history, development and delivery inform the discussion. HIV prevention varied in different areas of Wales depending on the particular professional group involved, local ideologies regarding drug use treatment, and the extent to which HIV prevention was seen either as a specialist area of expertise and specific remit of drug workers or a generic health care task. Drug agencies with an abstinence policy rejected syringe exchange; instead, prevention in those areas developed in ad hoc ways as health care workers and pharmacists attempted to develop a community based service. Drug agencies with a pre-existing harm minimisation model easily integrated syringe exchange into their work and played the major part in establishing the service, but there was difficulty in extending it beyond their professional caseloads. As there were disincentives to use treatment agencies, and their catchment areas were limited, these factors influenced effective service provision.

  10. Empirically Derived Dehydration Scoring and Decision Tree Models for Children With Diarrhea: Assessment and Internal Validation in a Prospective Cohort Study in Dhaka, Bangladesh.

    Science.gov (United States)

    Levine, Adam C; Glavis-Bloom, Justin; Modi, Payal; Nasrin, Sabiha; Rege, Soham; Chu, Chieh; Schmid, Christopher H; Alam, Nur H

    2015-08-18

    Diarrhea remains one of the most common and most deadly conditions affecting children worldwide. Accurately assessing dehydration status is critical to determining treatment course, yet no clinical diagnostic models for dehydration have been empirically derived and validated for use in resource-limited settings. In the Dehydration: Assessing Kids Accurately (DHAKA) prospective cohort study, a random sample of children under 5 with acute diarrhea was enrolled between February and June 2014 in Bangladesh. Local nurses assessed children for clinical signs of dehydration on arrival, and then serial weights were obtained as subjects were rehydrated. For each child, the percent weight change with rehydration was used to classify subjects with severe dehydration (>9% weight change), some dehydration (3-9%), or no dehydration (Dehydration Score and DHAKA Dehydration Tree, respectively. Models were assessed for their accuracy using the area under their receiver operating characteristic curve (AUC) and for their reliability through repeat clinical exams. Bootstrapping was used to internally validate the models. A total of 850 children were enrolled, with 771 included in the final analysis. Of the 771 children included in the analysis, 11% were classified with severe dehydration, 45% with some dehydration, and 44% with no dehydration. Both the DHAKA Dehydration Score and DHAKA Dehydration Tree had significant AUCs of 0.79 (95% CI = 0.74, 0.84) and 0.76 (95% CI = 0.71, 0.80), respectively, for the diagnosis of severe dehydration. Additionally, the DHAKA Dehydration Score and DHAKA Dehydration Tree had significant positive likelihood ratios of 2.0 (95% CI = 1.8, 2.3) and 2.5 (95% CI = 2.1, 2.8), respectively, and significant negative likelihood ratios of 0.23 (95% CI = 0.13, 0.40) and 0.28 (95% CI = 0.18, 0.44), respectively, for the diagnosis of severe dehydration. Both models demonstrated 90% agreement between independent raters and good

  11. Variations in prison mental health services in England and Wales.

    Science.gov (United States)

    Forrester, Andrew; Exworthy, Tim; Olumoroti, Olumuyiwa; Sessay, Mohammed; Parrott, Janet; Spencer, Sarah-Jane; Whyte, Sean

    2013-01-01

    In responding to high levels of psychiatric morbidity amongst prisoners and recognising earlier poor quality prison mental health care, prison mental health in-reach teams have been established in England and Wales over the last decade. They are mostly provided by the National Health Service (NHS), which provides the majority of UK healthcare services. Over the same period, the prison population has grown to record levels, such that prisons in England and Wales now contain almost 90,000 of the world's overall prison population of over 10 million people (roughly the size of Paris or Istanbul). This study provides an overview of mental health in-reach services in prisons in England and Wales, including variations between them, through a telephone survey of senior staff in all prisons and young offender institutions in England and Wales. 73% of prisons took part; of them 13% had no in-reach team at all (usually low security establishments) and the majority of services were run by NHS teams, usually according to a generic community mental health team (CMHT) model rather than other specialist models. Team size was unrelated to prison size. Each nurse covered around 500 prisoners, each doctor over 3700. Many provided few or no healthcare cells and 24-h psychiatric cover (including on-call cover) was uncommon. Despite developments in recent years, mental health in-reach services still fall short of community equivalence and there is wide variation in service arrangements that cannot be explained by prison size or function. The aim of community equivalence has not yet been reached in prison healthcare and a more sophisticated measure of service improvement and standardisation would now be useful to drive and monitor future development. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. Euthanasia: a summary of the law in England and Wales.

    Science.gov (United States)

    Simillis, Constantinos

    2008-07-01

    When medical treatment becomes futile, or the patient's suffering is intractable, doctors face the agonising dilemma of whether to proceed with euthanasia. It is important for a doctor to be familiar with the law surrounding euthanasia, in order to avoid prosecution. This paper explores the law in England and Wales regarding the different categories of euthanasia: voluntary euthanasia, nonvoluntary euthanasia, passive euthanasia, and active euthanasia.

  13. Myxomatosis in farmland rabbit populations in England and Wales.

    OpenAIRE

    Ross, J.; Tittensor, A. M.; Fox, A. P.; Sanders, M. F.

    1989-01-01

    The overall pattern and consequences of myxomatosis in wild rabbit populations were studied at three farmland sites in lowland southern England and upland central Wales between 1971 and 1978. When results from all years were combined, the disease showed a clear two-peaked annual cycle, with a main autumn peak between August and January, and a subsidiary spring peak during February to April. Rabbit fleas, the main vectors of myxomatosis in Britain, were present on full-grown rabbits in suffici...

  14. Crime and immigration: new evidence from England and Wales

    OpenAIRE

    Laura Jaitman; Stephen Machin

    2013-01-01

    We study a high profile public policy question on immigration, namely the link between crime and immigration, presenting new evidence from England and Wales in the 2000s. For studying immigration impacts, this period is of considerable interest as the composition of migration to the UK altered dramatically with the accession of Eastern European countries (the A8) to the European Union in 2004. As we show, this has important implications for ensuring a causal impact of immigration can be ident...

  15. Courtship, sex and poverty: illegitimacy in eighteenth-century Wales.

    Science.gov (United States)

    Muir, Angela Joy

    2018-01-01

    This article sheds new light on illegitimacy in eighteenth-century Britain through an analysis of evidence from 36 parishes across the former Welsh counties Montgomeryshire and Radnorshire. Quantitative analysis of illegitimacy ratios demonstrates that levels were significantly higher in certain, but not all, parts of Wales in the eighteenth century. This evidence is considered in relation to explanatory frameworks used in the analysis of English data, which attempt to account for rising levels through cultural changes that influenced premarital sexual behaviour, and economic opportunities created by industrialization. Welsh evidence appears to present a challenge to these understandings in two key ways: Wales was linguistically different and lacked certain cultural markers which some historians have associated with an eighteenth-century 'sexual revolution', and because the highest levels of illegitimacy were found in agricultural regions of Wales which experienced little or no industrial change. It is argued that Welsh illegitimacy was influenced by a combination of courtship-led marriage customs, a decline in traditional forms of social control and worsening economic circumstances which, on closer examination, appear remarkably similar to London. This analysis provides further evidence that illegitimacy in eighteenth-century Britain was a deeply complex phenomenon governed by diverse regionally specific social and economic influences.

  16. A Single-Center Pilot Prospective Study of Topical Application of Platelet-Derived Eye Drops for Patients with Ocular Chronic Graft-versus-Host Disease.

    Science.gov (United States)

    Zallio, Francesco; Mazzucco, Laura; Monaco, Federico; Astori, Maria Rosa; Passera, Roberto; Drago, Giovanna; Tamiazzo, Stefania; Rapetti, Manuela; Dolcino, Daniela; Guaschino, Roberto; Pini, Massimo; Ladetto, Marco

    2016-09-01

    Ocular involvement of chronic graft-versus-host disease (cGVHD) is a complication that occurs in up to 60% of patients after allogeneic hematopoietic stem cell transplantation. Conventional therapeutic options include medical and surgical procedures that are administered depending on the severity of the condition, but most of them have provided unsatisfactory results and, to date, there is no consensus about treatment. We considered that topical application of a platelet lysate, administered as eye drops, might be considered an alternative worthwhile of investigation to treat ocular surface disorders in patients suffering from cGVHD. Therefore, we conducted a single-center prospective pilot study to assess the efficacy and safety of using eye drops made from reconstituted lysed platelet concentrate. Twenty-six patients with ocular cGVHD were eligible for the study; all but 2 completed their scheduled 1-year treatment and complied with the hematologic and ophthalmic regimen. At their first assessment interviews, after 30 days of treatment, 91% of patients reported an improvement in their symptoms and for 32%, substantive objective differences were measured. Remission of corneal damage was seen for 86% of our cohort, and improved National Institutes of Health scores for 73%, of whom 8% achieved the best score of 0 (ie, non-dry eye). Similar results were seen at later time points. Comparing outcomes for our patient cohort to those determined retrospectively for patients in our institutional database revealed a 5-year overall survival (OS) of 65%. This OS is comparable to patients with limited cGVHD (75%) and is superior to that of patients with nonocular extensive cGVHD or without cGVHD (30% and 59%, respectively) (P = .013). Our results suggest that platelet-derived eye drops are a safe, practical, and well-tolerated therapeutic option that offers substantial benefits for most patients affected by ocular cGVHD at onset. The favorable OS of our patient cohort

  17. Breaking the mould? Whiteness, masculinity, Welshness, working-classness and rugby league in Wales

    OpenAIRE

    Spracklen, K; Spracklen, C

    2012-01-01

    Traditionally, rugby in Wales has meant rugby union, the once-amateur, fifteen-a-side code that has a long history of working-class, male involvement in the Valleys of South Wales (Williams, G., 1985). In recent years, however, rugby union has been joined in South Wales by the non-traditionally Welsh sport of rugby league. Once upon a time, rugby league was the sport that “bought” Welsh rugby players who went north (Collins, 2006). Rugby league has now expanded into Wales, developing its vers...

  18. Identifying probable suicide clusters in wales using national mortality data.

    Directory of Open Access Journals (Sweden)

    Phillip Jones

    Full Text Available Up to 2% of suicides in young people may occur in clusters i.e., close together in time and space. In early 2008 unprecedented attention was given by national and international news media to a suspected suicide cluster among young people living in Bridgend, Wales. This paper investigates the strength of statistical evidence for this apparent cluster, its size, and temporal and geographical limits.The analysis is based on official mortality statistics for Wales for 2000-2009 provided by the UK's Office for National Statistics (ONS. Temporo-spatial analysis was performed using Space Time Permutation Scan Statistics with SaTScan v9.1 for suicide deaths aged 15 and over, with a sub-group analysis focussing on cases aged 15-34 years. These analyses were conducted for deaths coded by ONS as: (i suicide or of undetermined intent (probable suicides and (ii for a combination of suicide, undetermined, and accidental poisoning and hanging (possible suicides. The temporo-spatial analysis did not identify any clusters of suicide or undetermined intent deaths (probable suicides. However, analysis of all deaths by suicide, undetermined intent, accidental poisoning and accidental hanging (possible suicides identified a temporo-spatial cluster (p = 0.029 involving 10 deaths amongst 15-34 year olds centred on the County Borough of Bridgend for the period 27(th December 2007 to 19(th February 2008. Less than 1% of possible suicides in younger people in Wales in the ten year period were identified as being cluster-related.There was a possible suicide cluster in young people in Bridgend between December 2007 and February 2008. This cluster was smaller, shorter in duration, and predominantly later than the phenomenon that was reported in national and international print media. Further investigation of factors leading to the onset and termination of this series of deaths, in particular the role of the media, is required.

  19. The fertility of recent migrants to England and Wales

    Directory of Open Access Journals (Sweden)

    James Robards

    2016-06-01

    Full Text Available Background: Estimates of fertility for the overseas-born based on the period Total Fertility Rate (TFR suggest that levels of childbearing are significantly higher among foreign-born women than women born in the UK. However, migration and timing of subsequent family formation mean that aggregate measures of fertility based on period TFRs may not be a useful indicator of the likely completed family size that migrant women will have at the end of their reproductive lives. Objective: The paper quantifies childbearing according to duration since migration among female migrants to England and Wales arriving between 2001 and 2011, and examines how these patterns differ according to age at arrival and country of birth. Methods: Data from the Office for National Statistics Longitudinal Study, a 1Š sample of the population of England and Wales, are used to identify the reported date of arrival in the UK and to estimate childbearing prior to and subsequent to arrival. Results: Fertility rates peak in the first one to four years subsequent to arrival among migrants from Pakistan and Bangladesh. Migrants from India and Poland show a delay in childbearing after migration to England and Wales, and lower fertility rates compared to migrants from Pakistan and Bangladesh, who show high fertility after migration at least for the first five years. Conclusions: There are large differences in the timing of fertility among migrants according to age at arrival and migrant country of origin, which are likely to be related to the reason for migration. Tempo distortions among some migrant groups mean that the period TFR is not necessarily a useful summary measure of the likely lifetime fertility of migrant groups.

  20. Industrial relationships and nationalisation in the South Wales coalmining industry

    Energy Technology Data Exchange (ETDEWEB)

    Zweiniger-Bargielowska, I.-M. (University of Cambridge, Cambridge (United Kingdom))

    1990-01-01

    The thesis examines industrial relationships in the South Wales coal mining industry at a colliery level. Various industrial relations stereotypes in the industry and the effect of nationalization on them are examined. The study concentrates on the collieries rather than the communities, comparing four collieries. Colliery managers, underofficials and mineworkers are studied, both in themselves and in relation to each other. Insights are gained into the causes of conflict within the industry. It is concluded that the ownership of the industry is not a major determinant of the level of conflict. It is suggested that many established views on the mining work force and attitudes to nationalization, work and unions need reassessing.

  1. District nursing renascent as Wales adopts safe staffing levels.

    Science.gov (United States)

    Labourne, Paul

    2018-05-02

    This article reflects on the history of the NHS in Wales and how this has led to its current structure. How this structure supports integrated working across primary, community and secondary care and how further integration with social care is moving forward and its direct effects on district nursing are explored. This article describes how district nursing is meeting these challenges. Support for district nurses as part of integrated multiprofessional teams is being developed to promote appropriately staffed teams centred on meeting the requirements of people within a designated area and ensuring that home is the best and first place of care.

  2. Industrial hygiene survey. IMC, Phosphate Chemical Complex, New Wales, Florida

    International Nuclear Information System (INIS)

    Stephenson, F.; Cassady, M.

    1977-10-01

    An industrial hygiene survey was conducted by NIOSH at IMC Phosphate Chemical Complex, New Wales, Florida, on June 7-11, 1976, as part of a study of the phosphate industry. Phosphate fertilizer manufacturing, the plant, and the medical, safety, and industrial hygiene programs are described. During the study 8-hour time weighted averages were determined for exposure to arsenic, cadmium, chromium, vanadium, phosphoric acid, and sulfuric acid for workers involved in cleaning out phosphoric acid reactor vessels. General area samples were collected for fluorides, radon, and uranium. Several samples were above the NIOSH recommended levels for arsenic and chromium

  3. Open innovation: the activities and views of companies in Wales

    DEFF Research Database (Denmark)

    Rhisiart, Martin; Djebarni, Rami; Thomas, Andrew

    favoured by companies are: 1) Financial support for collaboration, 2) Increase co-funding schemes for SMEs’ R&D, 3) Improve the institutional framework for collaboration, 4) Improve access to governmental support, 5) Foster networks and clusters The report sets out seven key recommendations for promoting......This is the Final Report of a study conducted on open innovation in companies in Wales. The programme of research included a review of global literature, interviews with 15 companies, a survey and a focus group.The study discusses Government support measures for open innovation.  Those most...

  4. Naturally occurring radioactive materials at New South Wales mines

    International Nuclear Information System (INIS)

    McLaughlin, Robert

    2013-01-01

    Until recently mines in New South Wales have been largely exempt from the provisions of the Radiation Control Act with respect to radioactive ore being mined and processed. Legislative changes and the national harmonisation efforts for mine safety regulation have drawn attention to the emerging issue of naturally occurring radioactive material (NORM). While mine operators are already obliged under their duty of care to manage this hazard, specific control measures are increasingly expected by the community and regulators. This applies throughout the whole mine life cycle from exploration right through to rehabilitation.

  5. Discourses, Decisions, Designs: "Special" Education Policy-Making in New South Wales, Scotland, Finland and Malaysia

    Science.gov (United States)

    Chong, Pei Wen; Graham, Linda J.

    2017-01-01

    This comparative analysis investigates the influence of neo-liberal and inclusive discourses in "special" education policy-making in New South Wales, Scotland, Finland and Malaysia. The centrality of competition, selectivity and accountability in the discourses used in New South Wales and Malaysia suggests a system preference for…

  6. Radionuclide levels in food, animals and agricultural products. Post Chernobyl monitoring in England and Wales

    International Nuclear Information System (INIS)

    1987-01-01

    Data are presented in the following lists: 1) General Monitoring results, for England and Wales, presented separately (milk, milk products, dairy, vegetables, fruit, meat, fish, game, herbage, honey). 2) Restricted area sheep monitoring results, England and Wales presented separately. (U.K.)

  7. The Origins and Growth of Ragged Schools in Wales, 1847-c. 1900.

    Science.gov (United States)

    Grigg, Russell

    2002-01-01

    Investigates the establishment of ragged schools in nineteenth century Wales. States they dealt with the many shabbily clad, underprivileged youth found roaming the streets. Explains Wales focused on creating church and boarding schools. Concludes that other schools eventually provided welfare based services which caused ragged school's demise.…

  8. Distribution of cocaine on banknotes in general circulation in England and Wales.

    Science.gov (United States)

    Aitken, C G G; Wilson, A; Sleeman, R; Morgan, B E M; Huish, J

    2017-01-01

    A study of the quantities of cocaine on banknotes in general circulation was conducted to investigate regional variations across England and Wales. No meaningful support was found for the proposition that there is regional variation in the quantities of cocaine in banknotes in general circulation in England and Wales. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  9. Discharges to prison from medium secure psychiatric units in England and Wales.

    Science.gov (United States)

    Doyle, Michael; Coid, Jeremy; Archer-Power, Laura; Dewa, Lindsay; Hunter-Didrichsen, Alice; Stevenson, Rachel; Wainwright, Verity; Kallis, Costas; Ullrich, Simone; Shaw, Jenny

    2014-09-01

    Early findings from a national study of discharges from 32 National Health Service medium secure units revealed that nearly twice as many patients than expected were discharged back to prison. To compare the characteristics of those discharged back to prison with those discharged to the community, and consider the implications for ongoing care and risk. Prospective cohort follow-up design. All forensic patients discharged from 32 medium secure units across England and Wales over a 12-month period were identified. Those discharged to prison were compared with those who were discharged to the community. Nearly half of the individuals discharged to prison were diagnosed with a serious mental illness and over a third with schizophrenia. They were a higher risk, more likely to have a personality disorder, more symptomatic and less motivated than those discharged to the community. Findings suggest that alternative models of prison mental healthcare should be considered to reduce risks to the patient and the public. Royal College of Psychiatrists.

  10. Explaining wind power planning outcomes: some findings from a study in England and Wales

    International Nuclear Information System (INIS)

    Toke, Dave

    2005-01-01

    This paper discusses the factors that influence the outcome of onshore windfarm planning application in England and Wales. Various qualitative and quantitative methods have been employed, including regression analysis. Strong associations have been discovered between the outcome of local authority planning decisions, the opinions of local planning officers, the opinions of parish councils where the proposed windfarms are to be sited and the opinions of landscape protection groups. The attitude of people in the immediate vicinity of proposed windfarms is found to be the most important influence on the decisions made by local authorities. However, the local perception of the economic impact is of crucial importance in forming this judgement, as is the national political environment. The expected attitude of Appeal Inspectors is also important. It is concluded that there is a lot that wind power developers could do to improve the prospects of planning success. This includes engaging in local 'parish council' politics, talking to the closest residents to proposed schemes and encouraging local pro-wind power campaigns. Future projects are likely to be favoured by installing viewing towers at the tops of turbines to encourage visitors and in selling shares in the schemes to local people

  11. The electricity supply industry in England and Wales. Medium term development plan 1986-93

    International Nuclear Information System (INIS)

    1986-09-01

    The main objective of the Electricity Supply Industry in England and Wales is to develop and maintain electricity supplies to meet customers' needs as cheaply as possible. Over the medium term, 1986 - 1993, the goal is to reduce the real average price per kWh sold, whilst maintaining high standards of service and meeting financial obligations. The strategy set out comprises reducing controllable costs per kWh sold to 1992/3, pursuing a vigorous and selective marketing strategy so that an expected sales increase of 10% is achieved, securing a long term supply of coal at minimum cost by developing the commercial relationship with British Coal, increasing the proportion of electrical energy supplied by nuclear energy to 25% by 1992/3 and being environmentally concerned. The introduction outlines the medium term business, energy and economic environment, financial targets and price prospects. Plans to support the strategy outlined are presented. Each section sets out the objectives and the plans to achieve these. The strategy for new power stations is to develop fossil-fueled and nuclear as well as to develop alternative technologies. (UK)

  12. The Analysis of Prospects for Derivatives Market Development in Ukraine in View of Solving the Problems of its Normative Legal Regulation

    Directory of Open Access Journals (Sweden)

    Kolodizev Oleg M.

    2016-02-01

    Full Text Available The increased uncertainty in the country’s economy, impossibility of raising capital only by standard financial instruments substantiated the need for such financial innovations as derivatives. The relevance of the suggested topic is justified by the lack of strong legislative framework regulating the market of derivative financial instruments, as well as by significant demand for them in Ukraine. The aim of the article is to analyze the development level of the normative and legal field of trade in the derivatives market as well as the quality of the formed system of main indicators for derivatives trading in Ukraine. The paper identifies the problem, which could be neutralized through the use of derivative financial instruments. The volume and structure of the world and domestic derivatives markets have been analyzed. Based on the analysis of the legal field of regulating the market of derivative financial instruments as well as statistical analysis of its volume and structure, the reasons for the low activity in the considered market have been justified and recommendations to improve the current situation proposed.

  13. Reforming birth registration law in England and Wales?

    Directory of Open Access Journals (Sweden)

    Julie McCandless

    2017-06-01

    Full Text Available The Law Commission of England and Wales is considering what its 13th Programme of Law Reform should address. During the consultation process, a project on birth registration law has been mooted. This is a very welcome proposal given that civil birth registration in England and Wales is a compulsory procedure that not only finds its roots in the early Victorian era, but also remains very similar, at least in terms of form and the information that is recorded. I first use two recent legal challenges to illustrate why the current system is coming under increasing pressure. I further use these examples to caution against a law reform agenda that is narrowly focused on the precise information recorded, without a preliminary and wider examination of what the role and purpose of birth registration is, and should be, in society. I argue that this needs to be addressed before the state can justify the parameters of the information recorded. I then use an outline of historical reforms relating to the registration of births outside of marriage to highlight the normative two-parent family model that underpins the birth registration system. I argue that legal reform must be cognizant of the tenacity of this normative family model, particularly in relation to reform proposals surrounding donor conception and the annotation of birth certificates. Finally, I draw attention to wider developments in family law that cast birth registration as a social policy tool for the facilitation of parent–child relationships, particularly unmarried fathers.

  14. Electricity derivatives

    CERN Document Server

    Aïd, René

    2015-01-01

    Offering a concise but complete survey of the common features of the microstructure of electricity markets, this book describes the state of the art in the different proposed electricity price models for pricing derivatives and in the numerical methods used to price and hedge the most prominent derivatives in electricity markets, namely power plants and swings. The mathematical content of the book has intentionally been made light in order to concentrate on the main subject matter, avoiding fastidious computations. Wherever possible, the models are illustrated by diagrams. The book should allow prospective researchers in the field of electricity derivatives to focus on the actual difficulties associated with the subject. It should also offer a brief but exhaustive overview of the latest techniques used by financial engineers in energy utilities and energy trading desks.

  15. Detecting atmospheric pollution in surface soils using magnetic measurements: A reappraisal using an England and Wales database

    International Nuclear Information System (INIS)

    Blundell, A.; Hannam, J.A.; Dearing, J.A.; Boyle, J.F.

    2009-01-01

    Industrial activity such as burning of fossil fuels produces magnetically enhanced particulates. These particulates consist of coarse-grained multidomain and stable single domain magnetic minerals. Two threshold values of low field magnetic susceptibility (χ LF ) and frequency dependent susceptibility percentage (χ FD %) discriminate ferrimagnetic minerals of these sizes and can act as a tracer of magnetic pollution. Application of the thresholds to a magnetic topsoil data set (n = 5656 across England and Wales) revealed 637 samples potentially dominated by pollution particulates. The magnetic parameters of these samples display a negative correlation with distance to urban areas and positive correlations with metals associated with anthropogenic activity (Cu, Pb, and Zn). Results of experimentation with threshold values and modelling of magnetic anomalies suggest that regional factors such as geology and potential for pedogenic secondary magnetic enhancement should be considered when setting threshold values. - An application of magnetic susceptibility and frequency dependent susceptibility thresholds across England and Wales to determine topsoil dominated by pollution derived particles.

  16. Updated birth weight centiles for England and Wales.

    Science.gov (United States)

    Norris, Tom; Seaton, Sarah E; Manktelow, Brad N; Baker, Philip N; Kurinczuk, Jennifer J; Field, David; Draper, Elizabeth S; Smith, Lucy K

    2017-12-07

    Construct updated birth weight-for-gestational age centile charts for use in the UK and compare these to the currently used UK-WHO charts. Secondary analysis of national birth data. Centiles were constructed using 1 269 403 singleton births occurring in England and Wales in 2013-2014 as part of the MBRRACE-UK national perinatal surveillance programme. These were then validated using 642 737 singleton births occurring in England and Wales in 2015. Sex-specific birth weight-for-gestational age centiles. Centiles were created using the lambda-mu-sigma method via the GAMLSS package in R. This method transforms the skewed birth weight distribution to approximate a normal distribution, allowing any birth weight centile to be produced. The new centiles performed well in the validation sample, with the observed and expected proportion of births below a given centile in agreement. Overall, driven by the predominance of term births, the UK-WHO charts classify a smaller proportion of infants as below a given centile. For example, the UK-WHO estimates classified only 1.32% (8035/606 430) of term infants born in 2015 as below the second centile, compared with 1.97% (11 975/606 430) using the new MBRRACE-UK centiles. At the earliest gestational ages, however, the opposite is observed, with the UK-WHO classifying a larger proportion of infants as below a given centile, particularly at the lower end of the birthweight distribution. We have constructed and validated updated birth weight-for-gestational age centiles using a contemporary sample of births occurring in England and Wales. The benefits of these updated centiles will be first to assist the national surveillance of perinatal mortality programme by improving the identification of the proportion of stillbirths and neonatal deaths affected by intrauterine growth restriction and, second, to aid clinicians by more accurately identifying babies who require increased monitoring in the period immediately following birth.

  17. England and Wales: Stable fertility and pronounced social status differences

    Directory of Open Access Journals (Sweden)

    Wendy Sigle-Rushton

    2008-07-01

    Full Text Available For nearly three decades, the total fertility rate in England and Wales has remained high relative to other European countries, and stable at about 1.7 births per woman. In this chapter, we examine trends in both period and cohort fertility throughout the twentieth century, and demonstrate some important differences across demographic and social groups in the timing and quantum of fertility. Breaking with a market-oriented and laissez-faire approach to work and family issues, the last 10 years have seen the introduction of new social and economic policies aimed at providing greater support to families with children. However, the effect of the changes is likely to be limited to families on the lower end of the income scale. Rather than facilitating work and parenthood, some policies create incentives for a traditional gendered division of labour. Fertility appears to have remained stable despite, rather than because of, government actions.

  18. Nutrient enhanced short rotation coppice for biomass in central Wales

    Energy Technology Data Exchange (ETDEWEB)

    Hodson, R.W.; Slater, F.M.; Lynn, S.F.; Randerson, P.F. [Univ. of Wales (United Kingdom)

    1993-12-31

    Two projects involving short rotation willow coppice are taking place on the eastern side of the Cambrian Mountains in central Wales. One project examines, as an alternative land use, the potential of short rotation willow coppice variously enhanced by combinations of lime, phosphorous and potassium fertilizers and also digested sewage sludge on an acidic upland site at an altitude of 260m. The first year results of this project are described in detail, showing the necessity for limestone additions and also demonstrating that of the four willow varieties established, Salix dasyclados is the only possible, profitable fuel crop. The other project involving willow in a filter bed system is outlined along with an additional project investigating the effect of sewage sludge additions on the Rubus fruticosus production in a birch dominated mixed deciduous woodland.

  19. Radiological assessment of private water supplies in Dolgellau, North Wales

    International Nuclear Information System (INIS)

    Green, D.; McReddie, R.; Holland, B.

    1993-01-01

    Water samples from 100 private water supplies in the Meirionnydd District Council area of Dolgellau, North Wales have been analysed for natural and artificial radionuclides and the elements Calcium and Strontium. In addition 20 of the 100 supplies were specifically sampled for the measurement of radon-222. Of the 100 supplies tested all total alpha and beta values were within the WHO guideline values. An assessment of the radiological significance of the analytical data has been carried out by calculating the committed effective dose equivalent to a hypothetical critical group which would arise from the consumption of water during a single year. The maximum adult annual committed effective dose equivalent for artificial and total radionuclides measured during this programme of monitoring was found to be 3.2 and 560 μSv, respectively. (author)

  20. Worlds Largest Wave Energy Project 2007 in Wales

    DEFF Research Database (Denmark)

    Christensen, Lars; Friis-Madsen, Erik; Kofoed, Jens Peter

    2006-01-01

    This paper introduces world largest wave energy project being developed in Wales and based on one of the leading wave energy technologies. The background for the development of wave energy, the total resource ands its distribution around the world is described. In contrast to wind energy turbines...... Dragon has to be scaled in accordance with the wave climate at the deployment site, which makes the Welch demonstrator device the worlds largest WEC so far with a total width of 300 meters. The project budget, the construction methods and the deployment site are also given....... a large number of fundamentally different technologies are utilised to harvest wave energy. The Wave Dragon belongs to the wave overtopping class of converters and the paper describes the fundamentals and the technical solutions used in this wave energy converter. An offshore floating WEC like the Wave...

  1. Automated biosurveillance data from England and Wales, 1991-2011.

    Science.gov (United States)

    Enki, Doyo G; Noufaily, Angela; Garthwaite, Paul H; Andrews, Nick J; Charlett, André; Lane, Chris; Farrington, C Paddy

    2013-01-01

    Outbreak detection systems for use with very large multiple surveillance databases must be suited both to the data available and to the requirements of full automation. To inform the development of more effective outbreak detection algorithms, we analyzed 20 years of data (1991-2011) from a large laboratory surveillance database used for outbreak detection in England and Wales. The data relate to 3,303 distinct types of infectious pathogens, with a frequency range spanning 6 orders of magnitude. Several hundred organism types were reported each week. We describe the diversity of seasonal patterns, trends, artifacts, and extra-Poisson variability to which an effective multiple laboratory-based outbreak detection system must adjust. We provide empirical information to guide the selection of simple statistical models for automated surveillance of multiple organisms, in the light of the key requirements of such outbreak detection systems, namely, robustness, flexibility, and sensitivity.

  2. A mysterious giant ichthyosaur from the lowermost Jurassic of Wales

    Directory of Open Access Journals (Sweden)

    Jeremy E. Martin

    2015-12-01

    Full Text Available Ichthyosaurs rapidly diversified and colonised a wide range of ecological niches during the Early and Middle Triassic period, but experienced a major decline in diversity near the end of the Triassic. Timing and causes of this demise and the subsequent rapid radiation of the diverse, but less disparate, parvipelvian ichthyosaurs are still unknown, notably because of inadequate sampling in strata of latest Triassic age. Here, we describe an exceptionally large radius from Lower Jurassic deposits at Penarth near Cardiff, south Wales (UK the morphology of which places it within the giant Triassic shastasaurids. A tentative total body size estimate, based on a regression analysis of various complete ichthyosaur skeletons, yields a value of 12–15 m. The specimen is substantially younger than any previously reported last known occurrences of shastasaurids and implies a Lazarus range in the lowermost Jurassic for this ichthyosaur morphotype.

  3. Building regulations in energy efficiency: Compliance in England and Wales

    International Nuclear Information System (INIS)

    Pan Wei; Garmston, Helen

    2012-01-01

    There is an international pragmatic shift towards the use of building energy regulations, standards and codes to reduce building energy consumption. The UK Government revised Building Regulations in 2002, 2006 and 2010, towards more stringent energy efficiency standards and ultimately the target of ‘zero carbon’ new homes from 2016. This paper aims to: reveal levels of compliance with energy Building Regulations of new-build dwellings in England and Wales; explore underlying issues; and identify possible solutions. In total 376 new-build dwellings were investigated. The compliance revealed was poor, at a level of 35%; accompanied by 43% ‘grey compliance’ and 21% ‘grey non-compliance’ (due to insufficient evidence of achieving required carbon emissions reductions). It is a serious concern when building control approves so many dwellings when insufficient evidence of compliance has been received. Underlying issues were centred on: incorrect compilation and/or insufficient submission of carbon emissions calculations by builders/developers; inappropriate timings of such submissions; and a paucity of proper checks by building control. Exploring these issues reveals a complex system of factors influencing energy regulations compliance, which involves a wide range of stakeholders. The findings should inform the formulation and implementation of energy efficiency building regulations and policy in the future. - Highlights: ► The compliance with energy Building Regulations (England and Wales) was poor. ► The problematic implementation of energy Building Regulations is a serious concern. ► Identified issues suggest a lack of knowledge of builders and building control. ► There is a complex system of factors influencing energy regulations compliance. ► A systems approach is needed to improve compliance, while training is crucial.

  4. North Wales Group report on the effects of the Chernobyl accident

    International Nuclear Information System (INIS)

    1987-11-01

    A report is presented by the North Wales Group concerning the sequence of events affecting North Wales and the identification of the residual problems following contamination from the Chernobyl accident. The first part of the report attempts to establish a time scale for radiation restrictions applicable in North Wales and the size of the areas which are involved. Part two deals with national arrangements to handle incidents like Chernobyl and examines the wider field of international arrangements. A review is given of events as seen by the affected community following the Chernobyl accident. (U.K.)

  5. Joint Coal Board. Thirty-eighth annual report 1984/1985. [New South Wales

    Energy Technology Data Exchange (ETDEWEB)

    1986-01-01

    The thirty-eighth annual report of the Joint Coal Board is presented. Included are the major activities of the Board, general statistics of the New South Wales coal industry, an industry review and the Board's financial statements.

  6. Prospects of an alternative treatment against Trypanosoma cruzi based on abietic acid derivatives show promising results in Balb/c mouse model.

    Science.gov (United States)

    Olmo, F; Guardia, J J; Marin, C; Messouri, I; Rosales, M J; Urbanová, K; Chayboun, I; Chahboun, R; Alvarez-Manzaneda, E J; Sánchez-Moreno, M

    2015-01-07

    Chagas disease, caused by the protozoa parasite Trypanosoma cruzi, is an example of extended parasitaemia with unmet medical needs. Current treatments based on old-featured benznidazole (Bz) and nifurtimox are expensive and do not fulfil the criteria of effectiveness, and a lack of toxicity devoid to modern drugs. In this work, a group of abietic acid derivatives that are chemically stable and well characterised were introduced as candidates for the treatment of Chagas disease. In vitro and in vivo assays were performed in order to test the effectiveness of these compounds. Finally, those which showed the best activity underwent additional studies in order to elucidate the possible mechanism of action. In vitro results indicated that some compounds have low toxicity (i.e. >150 μM, against Vero cell) combined with high efficacy (i.e. <20 μM) against some forms of T. cruzi. Further in vivo studies on mice models confirmed the expectations of improvements in infected mice. In vivo tests on the acute phase gave parasitaemia inhibition values higher those of Bz, and a remarkable decrease in the reactivation of parasitaemia was found in the chronic phase after immunosuppression of the mice treated with one of the compounds. The morphological alterations found in treated parasites with our derivatives confirmed extensive damage; energetic metabolism disturbances were also registered by (1)H NMR. The demonstrated in vivo activity and low toxicity, together with the use of affordable starting products and the lack of synthetic complexity, put these abietic acid derivatives in a remarkable position toward the development of an anti-Chagasic agent. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  7. Follow-up: Prospective compound design using the ‘SAR Matrix’ method and matrix-derived conditional probabilities of activity [v1; ref status: indexed, http://f1000r.es/56v

    Directory of Open Access Journals (Sweden)

    Disha Gupta-Ostermann

    2015-03-01

    Full Text Available In a previous Method Article, we have presented the ‘Structure-Activity Relationship (SAR Matrix’ (SARM approach. The SARM methodology is designed to systematically extract structurally related compound series from screening or chemical optimization data and organize these series and associated SAR information in matrices reminiscent of R-group tables. SARM calculations also yield many virtual candidate compounds that form a “chemical space envelope” around related series. To further extend the SARM approach, different methods are developed to predict the activity of virtual compounds. In this follow-up contribution, we describe an activity prediction method that derives conditional probabilities of activity from SARMs and report representative results of first prospective applications of this approach.

  8. Follow-up: Prospective compound design using the ‘SAR Matrix’ method and matrix-derived conditional probabilities of activity [v2; ref status: indexed, http://f1000r.es/59v

    Directory of Open Access Journals (Sweden)

    Disha Gupta-Ostermann

    2015-04-01

    Full Text Available In a previous Method Article, we have presented the ‘Structure-Activity Relationship (SAR Matrix’ (SARM approach. The SARM methodology is designed to systematically extract structurally related compound series from screening or chemical optimization data and organize these series and associated SAR information in matrices reminiscent of R-group tables. SARM calculations also yield many virtual candidate compounds that form a “chemical space envelope” around related series. To further extend the SARM approach, different methods are developed to predict the activity of virtual compounds. In this follow-up contribution, we describe an activity prediction method that derives conditional probabilities of activity from SARMs and report representative results of first prospective applications of this approach.

  9. Comparison of elderly suicide rates among migrants in England and Wales with their country of origin.

    Science.gov (United States)

    Shah, Ajit; Lindesay, James; Dennis, Mick

    2009-03-01

    The black and minority ethnic (BME) elderly population size in England and Wales has progressively increased over the last three decades. Only two studies, both well over a decade old, have compared suicide rates in BME groups in England and Wales with those in their country of origin. A study comparing suicide rates among elderly migrants in England and Wales and in their country of origin using the latest available mortality data from the Office of National Statistics and the World Health Organization was conducted. There were wide variations in standardised mortality ratios for elderly suicides among migrants from different countries compared with those born in England and Wales and in their country of origin. There was convergence towards elderly suicide rates for England and Wales in some migrant groups in males in the age-bands 65-74 years and 75 + years, and in females in the age-band 75 + years. However, males aged 75 + years from most migrant groups had higher rates than those born in England and Wales. A more detailed analysis of suicide of older people from migrant groups is required to determine vulnerability and protective influences.

  10. Improving trauma imaging in Wales through Kotter's theory of change

    International Nuclear Information System (INIS)

    Maclean, D.F.W.; Vannet, N.

    2016-01-01

    Aim: To improve the practice of trauma computed tomography (CT) within Wales using recognised leadership techniques for change. Materials and methods: Royal College of Radiologists' (RCR) guidance, in addition to other key recent evidence, were used to form an aspirational standard. All centres across Wales with a major emergency department were included. Kotter's theory of change was utilised to facilitate an improvement in practice across the region, with larger units prioritised initially. Results: Of the 13 major emergency units in Wales, eight centres had no formal trauma CT protocol. Only one centre utilised the Bastion protocol (in comparison to 75% of major trauma centres). After the campaign to improve trauma imaging, seven centres now offer the Bastion protocol, with currently only three peripheral centres still without a procedure for whole-body CT. The two largest centres have implemented an emergency department pro forma. Conclusion: Trauma CT within Wales has significantly improved as a result of this project. Kotter's theory is demonstrated as an effective tool for facilitating a change in practice on a regional/national scale. - Highlights: • The practice of Trauma CT in Wales initially did not meet RCR guidance. • Kotter's theory of change was utilised to improve standards. • A superior quality of trauma imaging is now available across Wales.

  11. Financial Derivatives in China

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Francis Repka sees bright prospects for the future development of the financial derivatives market in China. Repka,Vice President of the Asian Bond Finance Department of Societe Generale, says the situation in France just after the birth of derivatives was very similar to the situation in China today.

  12. Perioperative echocardiography-derived right ventricle function parameters and early outcomes after tetralogy of Fallot repair in mid-childhood: a single-center, prospective observational study.

    Science.gov (United States)

    Raj, Ravi; Puri, Goverdhan Dutt; Jayant, Aveek; Thingnam, Shyam Kumar Singh; Singh, Rana Sandip; Rohit, Manoj Kumar

    2016-11-01

    Right ventricular (RV) function alterations are invariably present in all patients after tetralogy of Fallot (TOF) repair. Unlike the developed world where most of the patients with TOF are corrected in infancy, average age of presentation and thus surgery for these patients in the developing world may be higher. We aimed to study the correlation between RV function parameters such as tricuspid annular peak systolic excursion (TAPSE), fractional area change (FAC), and tricuspid annular peak systolic velocity (S') with early outcome variables after intracardiac repair for TOF. Fifty patients with a preoperative diagnosis of tetralogy of Fallot scheduled for corrective surgery were included in this single-center, prospective observational study. A preoperative transthoracic echocardiogram was performed to measure RV function parameters (FAC0, TAPSE0, S'0). Transthoracic echocardiography was repeated postoperatively to measure FAC1, TAPSE1, S'1 (day 1) and FAC2, TAPSE2, and S'2 (day 3). The relationship between preoperative and postoperative RV function parameters with in-hospital mortality, duration of mechanical ventilation, and intensive care unit stay was studied. The median age of patients was 6 years (range 1-14 years). Multiple stepwise logistic regression analysis showed RV FAC as best predictor of clinical outcome. Area under the receiver operating characteristic curve for postoperative RV function parameters, that is, FAC, TAPSE, and S' to predict early or delayed recovery was 0.944, 0.875, and 0.655, respectively. Among the RV function parameters studied, RV FAC best predicted the early outcome variables after TOF repair, followed by TAPSE while lateral tricuspid annular velocity S' being the least predictive. © 2016, Wiley Periodicals, Inc.

  13. Further statement on the incidence of childhood cancer in Wales

    International Nuclear Information System (INIS)

    1999-01-01

    In March 1999 the Welsh Office asked COMARE to examine two unpublished studies. The first by Busby et al of ''Green Audit'' concluded that there was a significant excess of childhood leukaemia in North Wales associated with residential proximity to the coast. The second study, carried out by Steward et al of the Welsh Cancer Intelligence and Surveillance Unit (WCISU), did not support this conclusion. We were asked to advise as to whether we considered that there was a real raised incidence of childhood leukaemia near the coast of North Wales and whether further study was required. To do this we initially organised a comparison of the figures quoted by both the Green Audit and WCISU with the database held by the Childhood Cancer Research Group (CCRG) in Oxford. This group maintains the National Registry of Childhood Tumours (NRCT), data for which are supplied from a variety of sources including cancer registries but also directly from medical cancer specialists as well as from death certificates. As a consequence this provides an independent check on much of the data on childhood cancer held by cancer registries in Great Britain and is clinically validated. After carrying out the independent check on the number of cases of childhood leukaemia in these Welsh counties it was immediately apparent that the data held by Green Audit, on which the analysis by Busby et al was based, were incorrect. These data were received from the Welsh Cancer Registry (WCR) in 1995. A further data set was received from WCR in 1996 but was not used in the analysis by Busby et al. In June 1999 we issued a statement to the Welsh Office. In that statement we noted that Dr Busby and his colleagues appeared to have used erroneous data in their study. On the basis of the Steward et al data, COMARE also stated that we found no evidence to support the contention that there is an increased incidence of childhood leukaemia or other childhood cancers amongst the Welsh population living close to the

  14. Human influences on streamflow drought characteristics in England and Wales

    Directory of Open Access Journals (Sweden)

    E. Tijdeman

    2018-02-01

    Full Text Available Human influences can affect streamflow drought characteristics and propagation. The question is where, when and why? To answer these questions, the impact of different human influences on streamflow droughts were assessed in England and Wales, across a broad range of climate and catchments conditions. We used a dataset consisting of catchments with near-natural flow as well as catchments for which different human influences have been indicated in the metadata (Factors Affecting Runoff of the UK National River Flow Archive (NRFA. A screening approach was applied on the streamflow records to identify human-influenced records with drought characteristics that deviated from those found for catchments with near-natural flow. Three different deviations were considered, specifically deviations in (1 the relationship between streamflow drought duration and the base flow index, BFI (specifically, BFIHOST, the BFI predicted from the hydrological properties of soils, (2 the correlation between streamflow and precipitation and (3 the temporal occurrence of streamflow droughts compared to precipitation droughts, i.e. an increase or decrease in streamflow drought months relative to precipitation drought months over the period of record. The identified deviations were then related to the indicated human influences. Results showed that the majority of catchments for which human influences were indicated did not show streamflow drought characteristics that deviated from those expected under near-natural conditions. For the catchments that did show deviating streamflow drought characteristics, prolonged streamflow drought durations were found in some of the catchments affected by groundwater abstractions. Weaker correlations between streamflow and precipitation were found for some of the catchments with reservoirs, water transfers or groundwater augmentation schemes. An increase in streamflow drought occurrence towards the end of their records was found for

  15. Human influences on streamflow drought characteristics in England and Wales

    Science.gov (United States)

    Tijdeman, Erik; Hannaford, Jamie; Stahl, Kerstin

    2018-02-01

    Human influences can affect streamflow drought characteristics and propagation. The question is where, when and why? To answer these questions, the impact of different human influences on streamflow droughts were assessed in England and Wales, across a broad range of climate and catchments conditions. We used a dataset consisting of catchments with near-natural flow as well as catchments for which different human influences have been indicated in the metadata (Factors Affecting Runoff) of the UK National River Flow Archive (NRFA). A screening approach was applied on the streamflow records to identify human-influenced records with drought characteristics that deviated from those found for catchments with near-natural flow. Three different deviations were considered, specifically deviations in (1) the relationship between streamflow drought duration and the base flow index, BFI (specifically, BFIHOST, the BFI predicted from the hydrological properties of soils), (2) the correlation between streamflow and precipitation and (3) the temporal occurrence of streamflow droughts compared to precipitation droughts, i.e. an increase or decrease in streamflow drought months relative to precipitation drought months over the period of record. The identified deviations were then related to the indicated human influences. Results showed that the majority of catchments for which human influences were indicated did not show streamflow drought characteristics that deviated from those expected under near-natural conditions. For the catchments that did show deviating streamflow drought characteristics, prolonged streamflow drought durations were found in some of the catchments affected by groundwater abstractions. Weaker correlations between streamflow and precipitation were found for some of the catchments with reservoirs, water transfers or groundwater augmentation schemes. An increase in streamflow drought occurrence towards the end of their records was found for some of the

  16. Clinical and echographic characteristics of patients exposed to fenfluramin or its derivatives: Results of a prospective, single-centre, observational study.

    Science.gov (United States)

    Cambon, David; Leclercq, Florence

    2015-03-01

    Fenfluramine and its derivatives have been associated with significant risk of developing valvular heart disease but its exact prevalence and severity are still debated. To evaluate the clinical and echocardiographic characteristics of patients hospitalized in a cardiology centre and who had past exposure to these drugs. Between July 2011 and February 2012, patients admitted to the hospitalization and intensive care units at the University Centre of Montpellier, France were questioned about past exposure to fenfluramine or its derivatives. In patients who reported exposure, a questionnaire assessing prescribing patterns and medical history was proposed and echocardiography performed. All of the usual echocardiographic variables were analysed. We applied criteria from a French multicentre registry for diagnosis of drug-induced valvulopathy: leaflets and subvalvular apparatus thickening and retraction, leaflets loss of coaptation, no calcification, and no stenosis. Ninety-five patients exposed to these drugs were included. The majority were female (n=62, 65.3%), 53.2% (n=50) had diabetes and 90.5% (n=86) were exposed to benfluorex. Mean treatment duration was 52.3months (95% confidence interval [CI] 39.0-65.6). Valvular regurgitations were observed in 64.0% of patients (n=57) while 19.8% (n=17) had pulmonary hypertension. Highly probable fenfluramine-induced regurgitations were present in 18.6% (n=16) of patients, possibly fenfluramine-induced regurgitations in 38.2% (n=34) of patients, and unlikely fenfluramine-induced regurgitations in 25.8% (n=23) of patients. Highly probable fenfluramine-induced regurgitations were mild to moderate in severity in all except three patients. Considering the frequency of probable or possible fenfluramine-induced regurgitations and in the absence of definite knowledge about the evolution of drug-induced valvular disease, systematic questioning about fenfluramine use may be advisable in hospitalized cardiac patients. Copyright © 2015

  17. Endogenizing Prospect Theory's Reference Point

    OpenAIRE

    Ulrich Schmidt; Horst Zank

    2010-01-01

    In previous models of (cumulative) prospect theory reference-dependence of preferences is imposed beforehand and the location of the reference point is exogenously determined. This note provides a foundation of prospect theory, where reference-dependence is derived from preference conditions and a unique reference point arises endogenously.

  18. Online conductivity monitoring of dialysis adequacy versus Kt/V derived from urea reduction ratio: A prospective study from a Saudi center

    Directory of Open Access Journals (Sweden)

    Khalid Al Saran

    2009-10-01

    Full Text Available Khalid Al Saran1, Alaa Sabry2, Mamdouh Abdulghafour1, Ahmed Yehia11Prince Salman Center for Kidney Disease, Riyadh, Kingdom of Saudi Arabia; 2Mansoura Urology and Nephrology Center, Mansoura University, Mansoura, EgyptIntroduction: Ad equate delivered dose of solute removal (as assessed by urea reduction and calculation of Kt/V is an important determinant of clinical outcome in chronic hemodialysis (HD patients. This requires both prescription of an adequate dose of HD and regular assessment that the delivered treatments are also adequate. Online conductivity monitoring using sodium flux as a surrogate for urea allows the repeated noninvasive measurement of Kt/V on each HD treatment.Methods: We prospectively studied 17 (9 males, 8 females established chronic HD patients over an eight-week period (408 treatments. A pre- and post-dialyzer measurement of the conductivity is performed by two mutually independent temperature-compensated conductivity cells equipped with Fresenius 4008 S® dialysis machines. Urea reduction was measured (once a week by a single pool calculation using immediate post-treatment sampling. No changes were made to any of the dialysis prescriptions over the study period. Values of calculated Kt/V and simultaneously obtained online Kt/V were compared.Results: There was a statistically significant difference between calculated Kt/V and online Kt/V over the study period. The mean calculated Kt/V was 1.37 ± 0.09, and mean online Kt/V 1.02 ± 0.15 (P = 0.000, calculated Kt/V ≥ 1.2 was achieved in all our patients while online Kt/V ≥ 1.2 was achieved in only 17.64 %. Yet there was moderate correlation between calculated Kt/V and online Kt/V (r2 = 0.48.Conclusions: Online conductivity monitoring results underestimates dialysis efficiency compared to calculated Kt/V readings. This difference has to be considered when applying Kt/V to clinical practice.Keywords: Kt/V, hemodialysis, online conductivity monitoring

  19. The inquiry into electricity supply in New South Wales

    International Nuclear Information System (INIS)

    Owen, Anthony D.

    2009-01-01

    In May 2007, the Premier of New South Wales (NSW) announced the establishment of an Inquiry into Electricity Supply in that State to be undertaken by the author of this paper. Fundamental to the Inquiry was the perceived need for additional baseload generating capacity, the identification of the available technologies, carbon constraints and the policy options that would encourage the private sector to undertake the required investments. Although NSW is part of the competitive National Electricity Market, State-owned generators dominate baseload supply. In addition, the State operates three electricity retailing businesses, has a monopoly on transmission and distribution, and provides price stability for NSW residential consumers through the Electricity Tariff Equalisation Fund. Overall, therefore, the State dominates the industry and, not surprisingly, potential private investors are sceptical that its market roles may be based upon criteria other than the purely commercial. The Inquiry's report, which was publicly released in September 2007, recommended sale of all State assets in both electricity generation and retail. This paper provides a rationale for that recommendation

  20. The inquiry into electricity supply in New South Wales

    Energy Technology Data Exchange (ETDEWEB)

    Owen, Anthony D. [School of Economics and Finance, Curtin Business School, Curtin University of Technology, Perth, WA 6845 (Australia)

    2009-02-15

    In May 2007, the Premier of New South Wales (NSW) announced the establishment of an Inquiry into Electricity Supply in that State to be undertaken by the author of this paper. Fundamental to the Inquiry was the perceived need for additional baseload generating capacity, the identification of the available technologies, carbon constraints and the policy options that would encourage the private sector to undertake the required investments. Although NSW is part of the competitive National Electricity Market, State-owned generators dominate baseload supply. In addition, the State operates three electricity retailing businesses, has a monopoly on transmission and distribution, and provides price stability for NSW residential consumers through the Electricity Tariff Equalisation Fund. Overall, therefore, the State dominates the industry and, not surprisingly, potential private investors are sceptical that its market roles may be based upon criteria other than the purely commercial. The Inquiry's report, which was publicly released in September 2007, recommended sale of all State assets in both electricity generation and retail. This paper provides a rationale for that recommendation. (author)

  1. Late entry to antenatal care in New South Wales, Australia

    Directory of Open Access Journals (Sweden)

    Rubin George

    2006-08-01

    Full Text Available Abstract Aims This study aimed to assess the prevalence of women who entered antenatal care (ANC late and to identify factors related to the late entry to ANC in New South Wales (NSW in 2004. Methods The NSW Midwives Data Collection contained data of 85,034 women who gave birth in 2004. Data were downloaded using SAS and transferred to STATA 8.0. Entering ANC after 12 weeks of gestation was classified as late. The Andersen Health Seeking Behaviour Model was used for selection and analyses of related factors. Regression and hierarchical analyses were used to identify significant factors and their relative contributions to the variation of pregnancy duration at entry to ANC. Results 41% of women commenced ANC after 12 weeks of gestation. Inequality existed between groups of women with predisposing characteristics and enabling resources contributed more to the variation in pregnancy duration at entry to ANC than needs. The groups of women with highest risk were teenagers, migrants from developing countries, women living in Western Sydney, Aboriginal and Torres Strait Islanders, women with three or more previous pregnancies and heavy smokers. The high risk groups with largest number of women were migrants from developing countries and women living in Western Sydney. Conclusion A large number of women in NSW entered ANC late in their pregnancies. Efforts to increase early entry to ANC should be targeted on identified high risk groups of women.

  2. Risk factors for ciprofloxacin-resistant Campylobacter infection in Wales.

    Science.gov (United States)

    Evans, Meirion R; Northey, Gemma; Sarvotham, Tinnu S; Hopkins, A Lynne; Rigby, Christine J; Thomas, Daniel Rh

    2009-08-01

    To identify risk factors for ciprofloxacin resistance in both travel-related and domestically acquired Campylobacter infection. Case-comparison study of patients with ciprofloxacin-resistant and ciprofloxacin-susceptible Campylobacter infection conducted in Wales during 2003 and 2004. Foreign travel was the major risk factor for ciprofloxacin-resistant infection [adjusted odds ratio (adjOR) 24.0, 95% confidence interval (95% CI) 12.6-45.9]. Among travellers, case patients were five times more likely to drink still bottled water (adjOR 4.7, 95% CI 1.0-21.7), whilst among non-travellers, case patients were three times more likely to drink sparkling bottled water (adjOR 3.3, 95% CI 1.5-7.4). There was no increased risk associated with eating poultry or prior quinolone use. Foreign travel remains the most important risk factor for ciprofloxacin-resistant Campylobacter infection. The possible association of both domestic- and travel-related ciprofloxacin-resistant Campylobacter infection with bottled water needs to be further explored.

  3. Recent trends in elderly suicide rates in England and Wales.

    Science.gov (United States)

    Hoxey, K; Shah, A

    2000-03-01

    The proportion of elderly in the population is increasing due to increased life expectancy and falling birth rate, and suicide rates increase with age. This study examined the following in England and Wales: (i) recent trends in the elderly suicide rate; (ii) recent trends in method-specific elderly suicide rate; (iii) the relationship between elderly population size and elderly suicide rate in recent years; and (iv) the sex difference in overall and method-specific elderly suicide rate. Data on the various suicide variables were ascertained from the annually published mortality data for years 1985 to 1996. The main findings of this study were: (i) there is a trend towards decline in the overall pure and combined suicide rates for elderly men and women over the 12 year study period; (ii) the main contributors to this decline are suicides due to poisoning by solid and liquid substances (E950), hanging, strangulation and suffocation (E953), drowning (E954), firearms and explosives (E955), and jumping from high places (E957); (iii) the overall pure and combined suicide rates and that for most categories of suicide was higher in men compared to women; and (iv) suicide rates decreased with an increase in the elderly population size. Suicide rates can decline due to a number of reasons. The challenge now is to ensure further decline in suicide rates to meet the Our Healthier Nations target.

  4. Victim support services in England, Wales and Northern Ireland

    Directory of Open Access Journals (Sweden)

    Ćopić Sanja M.

    2002-01-01

    Full Text Available In the paper, authors tried to present activities of one of the oldest European Victim Support Services - Victim Support for England, Wales and Northern Ireland. During 1970s, through practice and research projects, the need for recognizing the physical and psychological status of victims after the crime was committed, as well as the need of providing them with the (informal assistance and support were noticed. That has resulted in establishing numerous of local victim support services (schemes, which united in the National Association of the Victim Support Services in 1979. Significant support was given to the Service in 1980s through the recommendations of the Council of Europe on the assistance for victims of crime and prevention of victimization through direct support given to the victim immediately after the incident, including protection and safety, medical, mental, social and financial support, as well as providing the victim with information on his/her rights, support during the criminal proceeding, assistance in getting compensation etc. Organization and structure of the service, referral system, code of practice and two main programs: Victim Service and Witness Service are reviewed in the paper.

  5. Developing better casemix education for rural New South Wales.

    Science.gov (United States)

    Bridges, J F; Mazevska, D; Haas, M

    2001-08-01

    Casemix is now an important mechanism for the planning, evaluation and funding of health services in Australia. In New South Wales (NSW) it was believed that while staff from most hospitals in metropolitan Sydney had become both literate and vocal about casemix, staff from rural areas were less familiar and much less likely to participate in casemix initiatives. In conjunction with the NSW Casemix Clinical Committee (NCCC), NSW Health considered a special program of casemix education for rural NSW. Before an education program was attempted, NSW Health inquired into the specific needs for casemix education in rural NSW. Qualitative and quantitative methods of analysis were used. Results of the quantitative analysis indicate that the understanding of casemix classifications is highest among managers. Of concern were the relatively low proportion of Allied Health staff who had more than a vague understanding of the Sub- and Non-Acute Patient (SNAP) classification; the lack of any knowledge of the Mental Health Costing And Service Classification (MH-CASC) by nursing staff; and the lack of any knowledge of the emergency department classification: Urgency, Disposition and Age-related Groups (UDAG), either by clinical or nursing staff. The results of the qualitative analysis show that casemix education for rural areas needs to differ from metropolitan education programs. The analysis also highlights the perception of casemix in rural areas and the special circumstances in rural hospitals that place limits on the ability to use casemix more fully.

  6. Specialization in and within sexual offending in England and Wales.

    Science.gov (United States)

    Howard, Philip D; Barnett, Georgia D; Mann, Ruth E

    2014-06-01

    Existing evidence suggests that offenders tend not to specialize in sexual offending in general but that there is some specialization in particular types of sexual offending. This study examined the sexual histories and reoffending of a large, national data set of offenders convicted of a sexual offense and managed in England and Wales by the National Offender Management Service (N = 14,804). The study found that specialization in sexual offending compared to nonsexual offending was most evident for offenders with convictions for accessing indecent images. We also found considerable evidence of specialization within sexual offending, most notably for noncontact offenders, especially again indecent images offenders. Crossover between sexual offense types was very rare for those with contact adult offenses and for noncontact offenders although those with child contact offenses sometimes crossed over to indecent images reoffending. If specialization within sexual offending exists, the use of single risk assessment instruments to predict all types of sexual recidivism may be less effective than previously assumed. A comparison of different prediction models indicated that some items presently used in one-size-fits-all risk tools to predict any sexual reoffending only effectively predict certain subtypes of sexual offending. Statistically there appear to be some potential benefits to creating specialist risk predictors for different subtypes of offending, but further work is needed to justify the implementation demands that would be caused by abandoning one-size-fits-all tools.

  7. Exacerbation of oxidative stress during sickle vaso-occlusive crisis is associated with decreased anti-band 3 autoantibodies rate and increased red blood cell-derived microparticle level: a prospective study.

    Science.gov (United States)

    Hierso, Régine; Lemonne, Nathalie; Villaescusa, Rinaldo; Lalanne-Mistrih, Marie-Laure; Charlot, Keyne; Etienne-Julan, Maryse; Tressières, Benoit; Lamarre, Yann; Tarer, Vanessa; Garnier, Yohann; Hernandez, Ada Arce; Ferracci, Serge; Connes, Philippe; Romana, Marc; Hardy-Dessources, Marie-Dominique

    2017-03-01

    Painful vaso-occlusive crisis, a hallmark of sickle cell anaemia, results from complex, incompletely understood mechanisms. Red blood cell (RBC) damage caused by continuous endogenous and exogenous oxidative stress may precipitate the occurrence of vaso-occlusive crises. In order to gain insight into the relevance of oxidative stress in vaso-occlusive crisis occurrence, we prospectively compared the expression levels of various oxidative markers in 32 adults with sickle cell anaemia during vaso-occlusive crisis and steady-state conditions. Compared to steady-state condition, plasma levels of free haem, advanced oxidation protein products and myeloperoxidase, RBC caspase-3 activity, as well as the concentrations of total, neutrophil- and RBC-derived microparticles were increased during vaso-occlusive crises, whereas the reduced glutathione content was decreased in RBCs. In addition, natural anti-band 3 autoantibodies levels decreased during crisis and were negatively correlated with the rise in plasma advanced oxidation protein products and RBC caspase-3 activity. These data showed an exacerbation of the oxidative stress during vaso-occlusive crises in sickle cell anaemia patients and strongly suggest that the higher concentration of harmful circulating RBC-derived microparticles and the reduced anti-band 3 autoantibodies levels may be both related to the recruitment of oxidized band 3 into membrane aggregates. © 2016 John Wiley & Sons Ltd.

  8. Mechanism of Cancer Growth Suppression of Alpha-Fetoprotein Derived Growth Inhibitory Peptides (GIP): Comparison of GIP-34 versus GIP-8 (AFPep). Updates and Prospects

    Energy Technology Data Exchange (ETDEWEB)

    Mizejewski, Gerald J. [Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201 (United States)

    2011-06-20

    The Alpha-fetoprotein (AFP) derived Growth Inhibitory Peptide (GIP) is a 34-amino acid segment of the full-length human AFP molecule that inhibits tumor growth and metastasis. The GIP-34 and its carboxy-terminal 8-mer segment, termed GIP-8, were found to be effective as anti-cancer therapeutic peptides against nine different human cancer types. Following the uptake of GIP-34 and GIP-8 into the cell cytoplasm, each follows slightly different signal transduction cascades en route to inhibitory pathways of tumor cell growth and proliferation. The parallel mechanisms of action of GIP-34 versus GIP-8 are demonstrated to involve interference of signaling transduction cascades that ultimately result in: (1) cell cycle S-phase/G2-phase arrest; (2) prevention of cyclin inhibitor degradation; (3) protection of p53 from inactivation by phosphorylation; and (4) blockage of K{sup +} ion channels opened by estradiol and epidermal growth factor (EGF). The overall mechanisms of action of both peptides are discussed in light of their differing modes of cell attachment and uptake fortified by RNA microarray analysis and electrophysiologic measurements of cell membrane conductance and resistance. As a chemotherapeutic adjunct, the GIPs could potentially aid in alleviating the negative side effects of: (1) tamoxifen resistance, uterine hyperplasia/cancer, and blood clotting; (2) Herceptin antibody resistance and cardiac (arrest) arrhythmias; and (3) doxorubicin's bystander cell toxicity.

  9. BDNF Val 66 Met and 5-HTTLPR genotype moderate the impact of early psychosocial adversity on plasma brain-derived neurotrophic factor and depressive symptoms: a prospective study.

    Science.gov (United States)

    Buchmann, Arlette F; Hellweg, Rainer; Rietschel, Marcella; Treutlein, Jens; Witt, Stephanie H; Zimmermann, Ulrich S; Schmidt, Martin H; Esser, Günter; Banaschewski, Tobias; Laucht, Manfred; Deuschle, Michael

    2013-08-01

    Recent studies have emphasized an important role for neurotrophins, such as brain-derived neurotrophic factor (BDNF), in regulating the plasticity of neural circuits involved in the pathophysiology of stress-related diseases. The aim of the present study was to examine the interplay of the BDNF Val⁶⁶Met and the serotonin transporter promoter (5-HTTLPR) polymorphisms in moderating the impact of early-life adversity on BDNF plasma concentration and depressive symptoms. Participants were taken from an epidemiological cohort study following the long-term outcome of early risk factors from birth into young adulthood. In 259 individuals (119 males, 140 females), genotyped for the BDNF Val⁶⁶Met and the 5-HTTLPR polymorphisms, plasma BDNF was assessed at the age of 19 years. In addition, participants completed the Beck Depression Inventory (BDI). Early adversity was determined according to a family adversity index assessed at 3 months of age. Results indicated that individuals homozygous for both the BDNF Val and the 5-HTTLPR L allele showed significantly reduced BDNF levels following exposure to high adversity. In contrast, BDNF levels appeared to be unaffected by early psychosocial adversity in carriers of the BDNF Met or the 5-HTTLPR S allele. While the former group appeared to be most susceptible to depressive symptoms, the impact of early adversity was less pronounced in the latter group. This is the first preliminary evidence indicating that early-life adverse experiences may have lasting sequelae for plasma BDNF levels in humans, highlighting that the susceptibility to this effect is moderated by BDNF Val⁶⁶Met and 5-HTTLPR genotype. Copyright © 2013. Published by Elsevier B.V.

  10. Regenerative surgical therapy for peri-implantitis using deproteinized bovine bone mineral with 10% collagen, enamel matrix derivative and Doxycycline-A prospective 3-year cohort study.

    Science.gov (United States)

    Mercado, Faustino; Hamlet, Stephen; Ivanovski, Saso

    2018-05-16

    There is limited evidence regarding the long-term efficacy of regenerative treatment for peri-implantitis. The aim of this study was to evaluate a combination therapy of deproteinized bovine bone mineral with 10% collagen (DBBMC), enamel matrix derivative (EMD) and Doxycycline in the regeneration of bone defects associated with peri-implantitis. Thirty patients diagnosed with peri-implantitis (BoP/suppuration, probing depth greater than 4 mm, minimum radiographic bone loss of 20%, at least 2 years in function) were enrolled in the study. Clinical measurements included probing depths, recession, radiographic bone fill, gingival inflammation and bleeding on probing/suppuration. Following surgical access and debridement, the implant surfaces were decontaminated with 24% EDTA for 2 min, and the bone defects were filled with a combined mixture of DBBMC, EMD and Doxycycline powder. The defects were covered with connective tissue grafts where necessary. Clinical measurements were recorded after 12, 24 and 36 months. The mean probing depth and bone loss at the initial visit was 8.9 mm (±1.9) and 6.92 mm (±1.26), respectively. Both mean probing depth and bone loss reduced significantly from baseline to 3.55 mm (±0.50) and 2.85 mm (±0.73) at 12 months, 3.50 (±0.50) and 2.62 mm (±0.80) at 24 months and 3.50 mm (±0.50) and 2.60 mm (±0.73) at 36 months. 56.6% of the implants were considered successfully treated (according to Successful Treatment Outcome Criterion: PD 10%, no BoP/suppuration, no recession >0.5 mm for anterior implants and >1.5 mm for posterior implants) after 36 months. Regenerative treatment of peri-implantitis using a combined mixture of DBBMC, EMD and Doxycycline achieved promising results. The benefits of this protocol incorporating EMD should be tested in randomized clinical trials. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  11. Myxomatosis in farmland rabbit populations in England and Wales.

    Science.gov (United States)

    Ross, J; Tittensor, A M; Fox, A P; Sanders, M F

    1989-10-01

    The overall pattern and consequences of myxomatosis in wild rabbit populations were studied at three farmland sites in lowland southern England and upland central Wales between 1971 and 1978. When results from all years were combined, the disease showed a clear two-peaked annual cycle, with a main autumn peak between August and January, and a subsidiary spring peak during February to April. Rabbit fleas, the main vectors of myxomatosis in Britain, were present on full-grown rabbits in sufficient numbers for transmission to occur throughout the year, but the observed seasonal pattern of the disease appeared to be influenced by seasonal mass movements of these fleas. However other factors were also important including the timing and success of the main rabbit breeding season, the proportion of rabbits which had recovered from the disease and the timing and extent of autumn rabbit mortality from other causes. Significantly more males than females, and more adults and immatures than juveniles, were observed to be infected by myxomatosis. Only 25-27% of the total populations were seen to be infected during outbreaks. Using two independent methods of calculation, it was estimated that between 47 and 69% of infected rabbits died from the disease (much lower than the expected 90-95% for fully susceptible rabbits with the partly attenuated virus strains that predominated). Thus it was estimated that 12-19% of the total rabbit populations were known to have died directly or indirectly from myxomatosis. Although the effects of myxomatosis were much less than during the 1950s and 1960s, it continued to be an important mortality factor. It may still have a regulatory effect on rabbit numbers, with autumn/winter peaks of disease reducing the numbers of rabbits present at the start of the breeding season.

  12. Veterinary problems of endurance horses in England and Wales.

    Science.gov (United States)

    Nagy, A; Dyson, S J; Murray, J K

    2017-05-01

    Several studies have shown that a considerable proportion of horses are eliminated from endurance rides due to lameness and metabolic problems. Limited information is available on specific veterinary issues in endurance horses and there are no descriptive data on veterinary problems in a large population of endurance horses. The aim of this study was to describe veterinary problems occurring in endurance horses in England and Wales, the regions of the United Kingdom where endurance rides are organised and regulated by Endurance Great Britain (Endurance GB). A comprehensive online self-completed questionnaire was used for data collection (30th December 2015-29th February 2016) All members of Endurance GB who were the main rider of one or more endurance horses were eligible to participate. From the target population of 1209 horses, 190 questionnaires were completed by riders, resulting in a 15.7% response rate. The most common rider-reported veterinary problem was lameness, affecting 152/190 (80.0%) of endurance horses at some point during their careers and 101/190 (53.2%) of horses in the previous 12 months. Detailed information on the most recent episode of lameness was available for 147 horses. Seventy-six percent of these lameness episodes (112/147) had been initially identified by a veterinarian, but only 52% of these lameness episodes were investigated further by a veterinarian, despite the high proportion of horses affected by lameness and the proportion of horses with recurrent lameness episodes. The second most common veterinary problem was thoracolumbar region pain, followed by non-specific cough, skin disease and colic. Education of endurance riders may improve the number, quality and timing of veterinary investigations, especially for lameness and thoracolumbar region pain. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Radiotherapy utilization in New South Wales from 1996 to 1998

    International Nuclear Information System (INIS)

    Barton, M.; University of New South Wales, Sydney, NSW

    2000-01-01

    The purpose of the present study was to examine utilization rates of radiotherapy by newly diagnosed cancer patients in New South Wales (NSW) from 1996 to 1998. The 1989 report of the Australian Health Ministers' Advisory Council (AHMAC) recommended that 50% of all newly diagnosed cancer patients should receive radiotherapy. Previous reports showed that the true rate was between 30 and 36%. In 1991 and 1995 the NSW Department of Health developed strategic plans that were intended to implement the AHMAC recommendation. An analysis was carried out of activity reports of radiation oncology departments in NSW and its component Area Health Services (AHS). All NSW patients newly diagnosed with cancer between 1996 and 1998 and treated by radiotherapy were included in the study. A total of 37% of newly diagnosed cancer patients received radiotherapy in NSW in 1998. This has increased from 30% since 1990-91. Rural AHS in 1998 had an identical average rate of 37% (range: 23-54%) when compared to urban AHS (average: 37%; range: 26-49%). Rural AHS have increased utilization from 19% in 1990-91. Area health services with a radiation oncology department had a slightly higher rate of utilization than those AHS without a radiation oncology department (39 and 36%, respectively). The rates of utilization of radiotherapy in NSW in 1998 continued to be well below the benchmark set by AHMAC and varied widely between AHS. Attention to and expansion of services should be focused on both rural and urban areas of need. Copyright (1999) Blackwell Science Pty Ltd

  14. DNA barcoding the native flowering plants and conifers of Wales.

    Directory of Open Access Journals (Sweden)

    Natasha de Vere

    Full Text Available We present the first national DNA barcode resource that covers the native flowering plants and conifers for the nation of Wales (1143 species. Using the plant DNA barcode markers rbcL and matK, we have assembled 97.7% coverage for rbcL, 90.2% for matK, and a dual-locus barcode for 89.7% of the native Welsh flora. We have sampled multiple individuals for each species, resulting in 3304 rbcL and 2419 matK sequences. The majority of our samples (85% are from DNA extracted from herbarium specimens. Recoverability of DNA barcodes is lower using herbarium specimens, compared to freshly collected material, mostly due to lower amplification success, but this is balanced by the increased efficiency of sampling species that have already been collected, identified, and verified by taxonomic experts. The effectiveness of the DNA barcodes for identification (level of discrimination is assessed using four approaches: the presence of a barcode gap (using pairwise and multiple alignments, formation of monophyletic groups using Neighbour-Joining trees, and sequence similarity in BLASTn searches. These approaches yield similar results, providing relative discrimination levels of 69.4 to 74.9% of all species and 98.6 to 99.8% of genera using both markers. Species discrimination can be further improved using spatially explicit sampling. Mean species discrimination using barcode gap analysis (with a multiple alignment is 81.6% within 10×10 km squares and 93.3% for 2×2 km squares. Our database of DNA barcodes for Welsh native flowering plants and conifers represents the most complete coverage of any national flora, and offers a valuable platform for a wide range of applications that require accurate species identification.

  15. Factors associated with the recruitment and retention of social workers in Wales: employer and employee perspectives.

    Science.gov (United States)

    Evans, Sherrill; Huxley, Peter

    2009-05-01

    Despite acute staffing shortages in social work, workforce planning within the UK social care sector is compromised by poor workforce intelligence. This study aimed to inform the evidence base providing new data on recruitment and retention in Wales, examining what personal and organizational characteristics are associated with intentions to leave, and what initiatives or incentives might mediate that effect. A multi-method design facilitated comparisons between two data sources--a census of all 22 Welsh local authority employers about recruitment and retention practices and a survey of all social workers and senior practitioners employed in social services (n = 998; response rate 45.9%) about demography, workforce characteristics, working patterns, morale and plans and reasons for leaving one's job. Vacancy (mean 14.4%) and turnover (mean 15%) rates were statistically significantly higher in children's services than in adult services; vacancy rates were also higher in authorities that offered higher starting salaries. The provision of certain types of traineeship might also be associated with higher vacancy rates but these results should be treated with some caution. There was little evidence that recruitment and retention initiatives were associated with lower vacancy or turnover rates, despite employers' perceptions about their effectiveness. Social workers derived a lot of satisfaction from their work, but more than a quarter wanted to leave their job within 6 months, and almost as many were actively seeking alternative employment. Intention to leave was explained by job and employer satisfaction, and negative feelings about pay. Senior practitioners and staff members with longer lengths of service were less likely to want to leave, even if they were dissatisfied with their job or employer. Job and employer dissatisfaction was associated with retention initiatives related to facilities, good caseload management and home-working, suggesting that dissatisfied

  16. An estimation of intrapartum-related perinatal mortality rates for booked home births in England and Wales between 1994 and 2003.

    Science.gov (United States)

    Mori, R; Dougherty, M; Whittle, M

    2008-04-01

    The objective of this study was to obtain the best estimate of intrapartum-related perinatal mortality (IPPM) rates for booked home births. A population-based cross-sectional study. England and Wales. All births in England and Wales, including home births (intended or unintended) occurring between 1994 and 2003. All IPPM data were derived from the Confidential Enquiry into Maternal and Child Health. Denominators were derived by using unintended home births and transfer rates from home to hospital, from previous studies, with sensitivity analyses. IPPM rates were calculated for the three following subgroups: (a) the completed home birth group, (b) the transferred group and (c) the unintended home birth group. IPPM rate. The overall IPPM rate for England and Wales improved between 1994 and 2003. However, data to obtain a precise estimate of IPPM rate for booked home birth were not available. The average IPPM rate for all births in the study period was 0.79 per 1000 births (95% CI 0.77-0.81), and the estimated IPPM rate for booked home births was 1.28 or 0.74 per 1000 births, depending on the method of calculation (range 0.49-1.47). The IPPM rates for the completed home birth group appeared to be lower throughout the study period compared with the unintended home birth groups. Those women who had booked for a home birth, but later needed to transfer their care for a hospital birth, appeared to have the highest risk of IPPM in the study period. The results of this study need to be interpreted with caution due to inconsistencies occurring in the recorded data. However, the data do highlight two important features. First, they suggest that IPPM rates for home births do not appear to have improved over the study period examined, even though rates did so overall. Second, although the women who booked for home births and had their babies at home seemed to have a generally low IPPM rate, those who required their care to be transferred to hospital did not. Women who book for

  17. Memory, Television and the Making of the BBC’s 'The Story Of Wales'

    Directory of Open Access Journals (Sweden)

    Steve Blandford

    2013-06-01

    Full Text Available The production of television history programming is a rich site for examining the dynamic relationship between history and memory. This article approaches these dynamics through original, empirical research of a specific case study, BBC Wales’ The Story of Wales (Green Bay for BBC Wales 2012. It analyses the commissioning, production and presentation of a landmark national history programme within the specific context of a small nation (Wales and provides insights into how television intervenes in the construction, revision and remembering of the national past. The role of national histories in the construction of memory and national identity is importance at a time when the legitimacy of nations and states is under question and when governmental and political settlements are under construction as is the case in the post-devolutionary United Kingdom.

  18. Options for the management of Chernobyl-restricted areas in England and Wales

    International Nuclear Information System (INIS)

    Nisbet, A.; Woodman, R.

    1999-01-01

    Areas in England and Wales are still subject to restrictions on tile movement, sale and slaughter of sheep because concentrations of radiocaesium in sheep meat may exceed the 1000 Bq kg -1 limit imposed after the Chernobyl nuclear power plant accident. Various monitoring programmes have been implemented to enable lamb production to be sustained in these restricted areas, although no alternative management strategies have been considered to date. Current management practices have been reviewed and costed. An assessment has also been undertaken to establish the practicability and cost effectiveness of five alternative management options. The practicability of each option, which encompasses technical feasibility, capacity, cost, impact and acceptability, was assessed through a series of case studies carried out on farms in the restricted area of north Wales, and through consultation with a range of organisations with interests in farming and/or the environment. Recommendations are made for the future management of the restricted areas in England and Wales. (author)

  19. Simulating the effect of land use and climate change on upland soil carbon stock of Wales using ECOSSE

    Science.gov (United States)

    Rani Nayak, Dali; Gottschalk, Pia; Evans, Chris; Smith, Pete; Smith, Jo

    2010-05-01

    Within Wales soils hold between 400-500 MtC, over half of this carbon is stored in organic and organo-mineral soil which cover less than 20% of the land area of Wales. It has been predicted that climate change will increasingly have an impact on the C stock of soils in Wales. Higher temperatures will increase the rate of decomposition of organic matter, leading to increased C losses. However increased net primary production (NPP), leading to increased inputs of organic matter, may offset this. Land use plays a major role in determining the level of soil C and the direction of change in status (soil as a source or sink). We present here an assessment of the effect of land use change and climate change on the upland soil carbon stock of Wales in 3 different catchments i.e. Migneint, Plynlimon and Pontbren using a process-based model of soil carbon and nitrogen dynamics, ECOSSE. The uncertainties introduced in the simulations by using only the data available at national scale are determined. The ECOSSE model (1,2) has been developed to simulate greenhouse gas emissions from both organic and mineral soils. ECOSSE was derived from RothC (3) and SUNDIAL (4,5) and predicts the impacts of changes in land use and climate on emissions and soil carbon stock. Simulated changes in soil C are dependent on the type of land use change, the soil type where the land use change is occurring, and the C content of soil under the initial and final land uses. At Migneint and Plynlimon, the major part of the losses occurs due to the conversion of semi-natural land to grassland. Reducing the land use change from semi-natural to grassland is the main measure needed to mitigate losses of soil C. At Pontbren, the model predicts a net gain in soil C with the predicted land use change, so there is no need to mitigate. Simulations of future changes in soil C to 2050 showed very small changes in soil C due to climate compared to changes due to land use change. At the selected catchments, changes

  20. The Current Provision for Further and Higher Education in Wales. Coombe Lodge Working Paper. Information Bank Number 1627.

    Science.gov (United States)

    Marsh, D. T.

    Provision for postsecondary higher education in Wales, the nature of the Welsh system, and future concerns are discussed. The roles of the Welsh Office and the Welsh Joint Education Committee contrast greatly with central organizations in England. There is one university in Wales, comprising seven constituent colleges. Additional institutions in…

  1. Reconciling competing priorities in commissioning: the future of bone densitometry service for North Wales

    Directory of Open Access Journals (Sweden)

    Russell Ian

    2007-01-01

    Full Text Available Abstract Background Osteoporosis creates brittle bones susceptible to fracture, with resulting high levels of morbidity and mortality. Poor access to bone densitometry services for the residents of North Wales led to the Welsh Assembly Government offering capital to purchase a dual-energy X-ray absorptiometry (DXA scanner, used to diagnose osteoporosis, for the region. The commissioning question for the six Local Health Boards across North Wales was where to site the new scanner. This decision needed to reflect current inequalities in access to services and concerns over inappropriate prescribing relative to Welsh norms. Methods Epidemiological, corporate and comparative healthcare needs assessments were performed. In addition, two cross-sectional surveys were conducted to determine the views of general practices and users of bone densitometry services resident in North Wales. An option appraisal and sensitivity analysis of 13 costed options for DXA scanning was conducted. Results We estimated that only 31% of the people in North Wales who met national guidelines were receiving DXA scans. There was definite inequity of access to the current service provided by area of residence. There was also evidence of inequity of access by age and sex. The most suitable option identified in the option appraisal was a bone densitometry service based in the central location of Llandudno. Conclusion The assessment identified significant unmet need for DXA scanning. A recommendation was made to improve access through the introduction of a new bone densitometry service based at Llandudno. This would double scanning provision provided and reduce travel costs and time for many North Wales residents. This recommendation was adopted by a joint commissioning group established by the six Local Health Boards in North Wales at the end of 2004 – evidence based commissioning in practice.

  2. The geography of early childhood mortality in England and Wales, 1881-1911

    Directory of Open Access Journals (Sweden)

    Hannaliis Jaadla

    2017-12-01

    Full Text Available Background: Considerable regional variation existed in 19th-century infant mortality (IMR in England and Wales. Objective: This study estimates early childhood mortality (ECMR for over 2,000 registration subdistricts (RSDs of England and Wales and analyses spatial and temporal variations in IMR and ECMR between 1881 and 1911. Methods: The combination of mortality statistics from the Registrar General and individual-level census data from the Integrated Census Microdata (I-CeM project is used to estimate spatial models of the relationship between early childhood death rates and a range of district-specific contextual variables. Results: All regions of England and Wales experienced noticeable decline in early childhood mortality, but the spatial patterns were remarkably persistent, with high mortality in London and in the mining and textile centres. The earlier decline of childhood than infant mortality produced a widening gap between them, and in early phases this development was concentrated along the East-Midlands coastal area from Suffolk to North Yorkshire, and in mid-Wales. This gap continued to widen, and in 1911 IMR was at least twice as high as ECMR in most parts of England and Wales. Conclusions: The changing spatial pattern of ECMR was influenced by a set of factors over and above those that influenced IMR, and these were related more to the disease environment than to social and economic influences. Contribution: These new estimates of early childhood mortality, at a finer spatial scale than previously possible, highlight the vast spatial variation in mortality in England and Wales. It is likely that these regional differences also manifest in variation in other demographic outcomes.

  3. Who should do the dishes now? exploring gender and housework in contemporary urban South Wales

    OpenAIRE

    Mannay, Dawn

    2014-01-01

    This paper revisits Jane Pilcher’s (1994) seminal chapter from Our Sisters’ Land: The Changing Identities of Women in Wales - ‘Who should do the dishes? Three generations of Welsh women talking about men and housework’. Two decades on from the original study, the paper explores this question in contemporary south Wales by drawing upon data generated in a study of mothers and daughters residing in a Welsh, marginalised, urban housing area. Mothers of daughters in the two eldest groups tended t...

  4. Effect of Hydrogen Adsorption on the Stone-Wales Transformation in Small-Diameter Carbon Nanotubes

    Science.gov (United States)

    Openov, L. A.; Podlivaev, A. I.

    2018-04-01

    The effect of hydrogenation of (4, 0) and (3, 0) carbon nanotubes on the Stone-Wales transformation is studied in the framework of the nonorthogonal tight-binding model. It is shown that the atomic hydrogen adsorption can lead to both a decrease and an increase in the barriers for the direct and inverse transformations depending on the orientation of a rotating C-C bond with respect to the nanotube axis. The characteristic times of formation and annealing the Stone-Wales defects have been estimated. The Young's moduli have been calculated.

  5. Deemed consent: Assessing the new opt-out approach to organ procurement in Wales

    DEFF Research Database (Denmark)

    Albertsen, Andreas

    2018-01-01

    In December 2015, Wales became the first country in the UK to move away from an opt-in system in organ procurement. The new legislation introduces the concept of deemed consent whereby a person who neither opt in nor opt out is deemed to have consented to donation. The data released by the National...... Health Service (NHS) in July 2017 provide an excellent opportunity to assess this legislation in light of concerns that it would decrease procurement rates for living and deceased donation, as well as sparking an increase in family refusals. None of these concerns have come to pass, with Wales...

  6. Use of data mining techniques to investigate disease risk classification as a proxy for compromised biosecurity of cattle herds in Wales

    Directory of Open Access Journals (Sweden)

    Pfeiffer Dirk U

    2008-07-01

    Full Text Available Abstract Background Biosecurity is at the forefront of the fight against infectious diseases in animal populations. Few research studies have attempted to identify and quantify the effectiveness of biosecurity against disease introduction or presence in cattle farms and, when done, they have relied on the collection of on-farm data. Data on environmental, animal movement, demographic/husbandry systems and density disease determinants can be collated without requiring additional specific on-farm data collection activities, since they have already been collected for some other purposes. The aim of this study was to classify cattle herds according to their risk of disease presence as a proxy for compromised biosecurity in the cattle population of Wales in 2004 for risk-based surveillance purposes. Results Three data mining methods have been applied: logistic regression, classification trees and factor analysis. Using the cattle holding population in Wales, a holding was considered positive if at least bovine TB or one of the ten most frequently diagnosed infectious or transmissible non-notifiable diseases in England and Wales, according to the Veterinary Investigation Surveillance Report (VIDA had been diagnosed in 2004. High-risk holdings can be described as open large cattle herds located in high-density cattle areas with frequent movements off to many locations within Wales. Additional risks are associated with the holding being a dairy enterprise and with a large farming area. Conclusion This work has demonstrated the potential of mining various livestock-relevant databases to obtain generic criteria for individual cattle herd biosecurity risk classification. Despite the data and analytical constraints the described risk profiles are highly specific and present variable sensitivity depending on the model specifications. Risk profiling of farms provides a tool for designing targeted surveillance activities for endemic or emerging diseases

  7. The Radical Reform of Administrative Policies in New South Wales School Education: Practical and Theoretical Implications.

    Science.gov (United States)

    Macpherson, R. J. S.

    The government of New South Wales (Australia) is attempting to enhance the quality of public education by radically altering management structures and practices. Despite some popular objections, political intervention was mandated and warranted due to excessive centralization in administrative policy making, curriculum development, and resource…

  8. The Role of Trust in the Development of Connectivities amongst Rural Elders in England and Wales

    Science.gov (United States)

    Curry, Nigel; Fisher, Rhiannon

    2012-01-01

    Using Simmel's notion of sociation, the way in which rural elders in England and Wales relate to, or connect with, each other and others within their community, can be seen to be conflictual as well as consensual. As a vehicle for exploiting this relationship, social capital also can be antithetic as well as convergent and an important element of…

  9. Neutropenia and agranulocytosis in England and Wales: incidence and risk factors

    NARCIS (Netherlands)

    van Staa, T. P.; Boulton, F.; Cooper, C.; Hagenbeek, A.; Inskip, H.; Leufkens, H. G. M.

    2003-01-01

    The objectives of this study were to estimate the incidence of idiosyncratic neutropenia and agranulocytosis in England and Wales and to evaluate their risk factors and outcomes. The study was conducted using data from the General Practice Research Database. All cases of idiosyncratic neutropenia or

  10. Qualitative scale for estimating sulphur dioxide air pollution in England and Wales using epiphytic lichens

    Energy Technology Data Exchange (ETDEWEB)

    Hawksworth, D L; Rose, F

    1970-01-01

    The sulphur dioxide in the air can be estimated qualitatively by studying the lichens growing on trees. A ten-point scale has been constructed and used in pilot surveys in England and Wales, Southeast England and the city of Leicester.

  11. From Assimilation to Anti-Racism: Changing Educational Policies in England and Wales.

    Science.gov (United States)

    Watson, J. K. P.

    1988-01-01

    Although multicultural education has long been touted as an important educational goal in schools in England and Wales, very little has actually changed. Some individuals purporting to support anti-racist education and some governmental policies have actually undermined the little progress made toward preparing teachers and students for a…

  12. Mortality among a Cohort of Persons with an Intellectual Disability in New South Wales, Australia

    Science.gov (United States)

    Florio, Tony; Trollor, Julian

    2015-01-01

    Objectives: The main objective of the study was to compare mortality for people with an intellectual disability (ID) to the general population in New South Wales (NSW), Australia. A second objective was to provide mortality data for people with an intellectual disability from NSW in a standardized format, which allows for international comparisons…

  13. Rural partnerships in Europe, a differentiated view frm a country perspective: the Netherlands and Wales

    NARCIS (Netherlands)

    Derkzen, P.H.M.

    2010-01-01

    In recent years partnership has become an established aspect of rural development across rural Europe. Both Wales and the Netherlands have seen similar trends towards more decentralized and territorial modes of rural governance in which policy networks of governmental and societal actors work

  14. Women's Work or Creative Work? Embroidery in New South Wales High Schools

    Science.gov (United States)

    Wood, Susan

    2009-01-01

    Embroidery is traditionally regarded as women's work and the teaching of embroidery as a means of preparing young women for domesticity, a view which has been reinforced by historians studying changes in the high school art curriculum that occurred with the introduction of the Wyndham Scheme in New South Wales in the early 1960s. This paper argues…

  15. Brief Report: Multilevel Analysis of School Smoking Policy and Pupil Smoking Behaviour in Wales

    Science.gov (United States)

    Wiium, Nora; Burgess, Stephen; Moore, Laurence

    2011-01-01

    A multilevel analysis of cross-sectional data from a survey involving 1941 pupils (in grades 10 and 11) and policy indicators developed from interviews with staff from 45 secondary schools in Wales examined the hypotheses that pupil smoking prevalence would be associated with: restrictive staff and pupil smoking policies; dissemination of school…

  16. Deprivation and mortality in non-metropolitan areas of England and Wales.

    Science.gov (United States)

    Jessop, E G

    1996-10-01

    To test the hypothesis that the relationship between deprivation and mortality is weaker among residents of non-metropolitan areas of England and Wales than among residents of metropolitan areas. This study compared mortality, expressed as standardised mortality ratios (SMRs), in residents of metropolitan and non-metropolitan districts at three levels of deprivation classified by an electoral ward deprivation score and by home and car ownership. SMRs were computed for all causes of death, for bronchitis and asthma (ICD9 codes 490-493), and for accident, violence, and poisoning (ICD9 codes 800-999). England and Wales. Members of the longitudinal study of the Office of Population Censuses and Surveys, a quasi-random 1% sample of the population of England and Wales. There was an association between deprivation and mortality which was clear for all cause mortality, more noticeable for respiratory disease, and less clear for deaths from accident, violence, and poison. In general, the results showed a remarkable similarity between metropolitan and non-metropolitan areas. This study does not support the hypothesis that the relationship between mortality and deprivation differs between residents of metropolitan and non-metropolitan areas of England and Wales.

  17. Fatal methadone and heroin overdoses : Time trends in England and Wales

    NARCIS (Netherlands)

    Neeleman, J; Farrell, M

    Study objective-Although the total number of self poisonings in England and Wales has dropped by 32%, the number involving methadone and/or heroin rose by 900% in 1974-92. Because of concern about the role of methadone in this increase, the part played by methadone and heroin in poisoning deaths in

  18. Indigenous Gambling Motivations, Behaviour and Consequences in Northern New South Wales, Australia

    Science.gov (United States)

    Breen, Helen M.; Hing, Nerilee; Gordon, Ashley

    2011-01-01

    Against a background of public health, we sought to examine and explain gambling behaviours, motivations and consequences of Indigenous Australians in northern New South Wales. Adhering to national Aboriginal and ethical guidelines and using qualitative methods, 169 Indigenous Australians were interviewed individually and in small groups using…

  19. Historical Child Sexual Abuse in England and Wales: The Role of Historians

    Science.gov (United States)

    Bingham, Adrian; Delap, Lucy; Jackson, Louise; Settle, Louise

    2016-01-01

    This article reflects on methodological and ethical issues that have shaped a collaborative project which aims to chart social, legal and political responses to child sexual abuse in England and Wales across the twentieth century. The etymological problem of searching for child sexual abuse in the historical archive is discussed, given that the…

  20. School Expenditure and School Performance: Evidence from New South Wales Schools Using a Dynamic Panel Analysis

    Science.gov (United States)

    Pugh, G.; Mangan, J.; Blackburn, V.; Radicic, D.

    2015-01-01

    This article estimates the effects of school expenditure on school performance in government secondary schools in New South Wales, Australia over the period 2006-2010. It uses dynamic panel analysis to exploit time series data on individual schools that only recently has become available. We find a significant but small effect of expenditure on…

  1. The Decline and Revival of Music Education in New South Wales Schools, 1920-1956

    Science.gov (United States)

    Chaseling, Marilyn; Boyd, William E.

    2014-01-01

    This paper overviews the decline and revival of music education in New South Wales schools from 1920 to 1956. Commencing with a focus on vocal music during the period up to 1932, a time of decline in music teaching, the paper examines initiatives introduced in 1933 to address shortcomings in music education, and the subsequent changes in…

  2. Morchella australiana sp. nov., an apparent Australian endemic from New South Wales and Victoria

    Science.gov (United States)

    An abundant fruiting of a black morel was encountered in temperate northwestern New South Wales (NSW), Australia, during a mycological survey in August 2010. The collection site was west of the Great Dividing Range in a young, dry sclerophyll woodland forest dominated by Eucalyptus and Callitris nor...

  3. Passages to Literature: Essays on Teaching in Australia, Canada, England, the United States, and Wales.

    Science.gov (United States)

    Milner, Joseph O'Beirne, Ed.; Milner, Lucy Floyd Morcock, Ed.

    Representing Australia, Canada, England, the United States, and Wales, this collection of essays focuses on ways in which teachers can adapt classroom activities and modify writing assignments to encourage personal response and exploration of texts. Essays, their authors, and nationalities are as follows: (1) "The River and Its Banks:…

  4. Ethical analysis of the new proposed mental health legislation in England and Wales

    Directory of Open Access Journals (Sweden)

    Lepping Peter

    2007-04-01

    Full Text Available Abstract This paper ethically analyses arising out the proposed changes to the Mental Health Act for England and Wales. It looks in particular at thea shift in philosophy that the author claims has occurred with the proposals away from rights-focused principles to more utilitarian or outcome-focused principles. It gives examples of these changes and explores itstheir consequences.

  5. Theoretical Framework of Leadership in Higher Education of England and Wales

    Science.gov (United States)

    Mukan, Nataliya; Havrylyuk, Marianna; Stolyarchuk, Lesia

    2015-01-01

    In the article the theoretical framework of leadership in higher education of England and Wales has been studied. The main objectives of the article are defined as analysis of scientific and pedagogical literature, which highlights different aspects of the problem under research; characteristic of the theoretical fundamentals of educational…

  6. A comparison of disease prevalence in general practice in the Netherlands and in England & Wales.

    NARCIS (Netherlands)

    Fleming, D.; Schellevis, F.; Linden, M. van der; Westert, G.

    2006-01-01

    General practice-based morbidity surveys have been conducted in the Netherlands and in England and Wales primarily to estimate disease prevalence and examine health inequalities. We have compared disease prevalence in general practice reported in the second Dutch Natinal Survey of General Practice

  7. Sustainability of Curriculum Development for Enterprise Education: Observations on Cases from Wales

    Science.gov (United States)

    Roffe, Ian

    2010-01-01

    Purpose: This paper aims to examine the variety of approaches to curriculum development for enterprise education developed for schools, further, and higher education under an Entrepreneurship Action Plan in Wales and to consider the sustainability issues for delivery in these sectors. Design/methodology/approach: This investigation adopted a case…

  8. Learning about Teacher Professional Learning: Case Studies of Schools at Work in New South Wales

    Science.gov (United States)

    McCulla, Norman; Gereige-Hinson, Josephine

    2005-01-01

    The extent of the human and financial resources that teachers have access to for their professional development, and the extent to which they have the capacity to determine when, how and with whom learning takes place, are key factors in determining the quality of professional learning that results. The New South Wales Department of Education and…

  9. School Outcomes in New South Wales and Queensland: A Regression Discontinuity Approach

    Science.gov (United States)

    Miller, Paul W.; Voon, Derby

    2014-01-01

    This paper examines the differences in school (NAPLAN) outcomes between New South Wales and Queensland. It shows that there are pronounced differences in Year 3 NAPLAN results between these states, though these dissipate when later class years are considered. The reasons for these state effects in school outcomes are explored using an empirical…

  10. New South Wales coal strategy. Volume 1 - strategic plan. Volume 2 - industry review

    Energy Technology Data Exchange (ETDEWEB)

    1983-01-01

    The committee has concluded that while the outlook for coal demand growth is less optimistic than it was in 1981, nonetheless significant additional opportunities will arise in the medium term and that proper planning will place New South Wales in a strong position to take advantage of them.

  11. Implementation of an Integrated Information Management System at the National Library of Wales: A Case Study

    Science.gov (United States)

    Evans, Manon Foster; Thomas, Sian

    2007-01-01

    Purpose: This paper aims to describe the experiences of the National Library of Wales in implementing an integrated information management system. Design/methodology/approach: Discusses the stages involved in the procurement process, data migration and general system implementation. Findings: Emphasises the need for a well-prepared yet flexible…

  12. An Analysis of Misconceptions in Science Textbooks: Earth Science in England and Wales

    Science.gov (United States)

    King, Chris John Henry

    2010-01-01

    Surveys of the earth science content of all secondary (high school) science textbooks and related publications used in England and Wales have revealed high levels of error/misconception. The 29 science textbooks or textbook series surveyed (51 texts in all) showed poor coverage of National Curriculum earth science and contained a mean level of one…

  13. Addressing water resources risk in England and Wales: Long term infrastructure planning in a private, regulated industry

    Science.gov (United States)

    Turner, Sean

    2015-04-01

    Water resources planning is a complex and challenging discipline in which decision makers must deal with conflicting objectives, contested socio-economic values and vast uncertainties, including long term hydrological variability. The task is arguably more demanding in England and Wales, where private water companies must adhere to a rigid set of regulatory planning guidelines in order to justify new infrastructural investments. These guidelines prescribe a "capacity expansion" approach to planning: ensure that a deterministic measure of supply, known as "Deployable Output," meets projected demand over a 25-year planning horizon. Deployable Output is derived using a method akin to yield analysis and is commensurate with the maximum rate of supply that a water resources system can sustain without incurring failure under a simulation of historical recorded hydrological conditions. This study examines whether Deployable Output analysis is fit to serve an industry in which: water companies are seeking to invest in cross-company water transfer schemes to deal with loss of water availability brought about by European environmental legislation and an increase in demand driven by population growth; water companies are expected address potential climate change impacts through their planning activities; and regulators wish to benchmark water resource system performance across the separate companies. Of particular interest, then, is the adequacy of Deployable Output analysis as a means to measuring current and future water shortage risk and comparing across supply systems. Data from the UK National River Flow Archive are used to develop a series of hypothetical reservoir systems in two hydrologically contrasting regions -- northwest England/north Wales and Southeast England. The systems are varied by adjusting the draft ratio (ratio of target annual demand to mean annual inflow), the inflow diversity (covariance of streamflow sequences supplying the system), the strength of

  14. The Needs of Child Victims of Trafficking: Practitioner Perspective on Supporting Children Through Partnership in Wales

    Directory of Open Access Journals (Sweden)

    Bernie Bowen-Thomson

    2018-03-01

    Full Text Available This article provides a first-person account of the Safer Wales program and the importance of capitalizing on the United Nations partnership principle which is one of the four major pillars considered essential in effectively combating human trafficking. The discussion includes reference to how various legislation has helped to strengthen the partnerships within Wales but that there remain several challenges. In addition to reviewing how Safer Wales builds and sustains partnerships, a case study is used to illustrate the relative effectiveness of such an approach. The article concludes with a number of practical observations to show the relative importance of partnerships to effectively combat the exploitation and/or trafficking of children. Este artículo ofrece un relato en primera persona del programa Safer Wales y la importancia de capitalizar el principio de asociación de las Naciones Unidas. Dicho principio es uno de los cuatro pilares considerados esenciales en la lucha eficaz contra el tráfico de personas. El desarrollo del tema incluye referencias a la forma en que la legislación ha ayudado a fortalecer las asociaciones que se han establecido en Gales, pero también hace notar que quedan algunos desafíos pendientes. Además de valorar la forma en que Safer Wales construye y ayuda a mantener asociaciones, se utiliza un estudio de caso para ilustrar la eficacia relativa de ese abordaje. El artículo termina con observaciones de tipo práctico que muestran la importancia de las asociaciones para combatir con eficacia la explotación y el tráfico de niños. DOWNLOAD THIS PAPER FROM SSRN: http://ssrn.com/abstract=3086497

  15. The future of smoking-attributable mortality: the case of England & Wales, Denmark and the Netherlands.

    Science.gov (United States)

    Stoeldraijer, Lenny; Bonneux, Luc; van Duin, Coen; van Wissen, Leo; Janssen, Fanny

    2015-02-01

    We formally estimate future smoking-attributable mortality up to 2050 for the total national populations of England & Wales, Denmark and the Netherlands, providing an update and extension of the descriptive smoking-epidemic model. We used smoking prevalence and population-level lung cancer mortality data for England & Wales, Denmark and the Netherlands, covering the period 1950-2009. To estimate the future smoking-attributable mortality fraction (SAF) we: (i) project lung cancer mortality by extrapolating age-period-cohort trends, using the observed convergence of smoking prevalence and similarities in past lung cancer mortality between men and women as input; and (ii) add other causes of death attributable to smoking by applying a simplified version of the indirect Peto-Lopez method to the projected lung cancer mortality. The SAF for men in 2009 was 19% (44 872 deaths) in England & Wales, 22% (5861 deaths) in Denmark and 25% (16 385 deaths) in the Netherlands. In our projections, these fractions decline to 6, 12 and 14%, respectively, in 2050. The SAF for women peaked at 14% (38 883 deaths) in 2008 in England & Wales, and is expected to peak in 2028 in Denmark (22%) and in 2033 in the Netherlands (23%). By 2050, a decline to 9, 17 and 19%, respectively, is foreseen. Different indirect estimation methods of the SAF in 2050 yield a range of 1-8% (England & Wales), 8-13% (Denmark) and 11-16% (the Netherlands) for men, and 7-16, 12-26 and 13-31% for women. From northern European data we project that smoking-attributable mortality will remain important for the future, especially for women. Whereas substantial differences between countries remain, the age-specific evolution of smoking-attributable mortality remains similar across countries and between sexes. © 2014 Society for the Study of Addiction.

  16. What choices should we be able to make about designer babies? A Citizens' Jury of young people in South Wales.

    Science.gov (United States)

    Iredale, Rachel; Longley, Marcus; Thomas, Christian; Shaw, Anita

    2006-09-01

    Young people will increasingly have the option of using new technologies for reproductive decision making but their voices are rarely heard in debates about acceptable public policy in this area. Capturing the views of young people about potentially esoteric topics, such as genetics, is difficult and methodologically challenging. A Citizens' Jury is a deliberative process that presents a question to a group of ordinary people, allows them to examine evidence given by expert witnesses and personal testimonies and arrive at a verdict. This Citizens' Jury explored designer babies in relation to inherited conditions, saviour siblings and sex selection with young people. Fourteen young people aged 16-19 in Wales. Acceptance of designer baby technology was purpose-specific; it was perceived by participants to be acceptable for preventing inherited conditions and to create a child to save a sibling, but was not recommended for sex selection. Jurors stated that permission should not depend on parents' age, although some measure of suitability should be assessed. Preventing potential parents from going abroad was considered impractical. These young people felt the Human Fertilisation and Embryology Authority should have members under 20 and that the term 'designer baby' was not useful. Perspectives on the acceptability of this technology were nuanced, and based on implicit value judgements about the extent of individual benefit derived. Young people have valuable and interesting contributions to make to the debate about genetics and reproductive decision making and a variety of innovative methods must be used to secure their involvement in decision-making processes.

  17. Comparison of mortality following hospitalisation for isolated head injury in England and Wales, and Victoria, Australia.

    Directory of Open Access Journals (Sweden)

    Belinda J Gabbe

    Full Text Available BACKGROUND: Traumatic brain injury (TBI remains a leading cause of death and disability. The National Institute for Health and Clinical Excellence (NICE guidelines recommend transfer of severe TBI cases to neurosurgical centres, irrespective of the need for neurosurgery. This observational study investigated the risk-adjusted mortality of isolated TBI admissions in England/Wales, and Victoria, Australia, and the impact of neurosurgical centre management on outcomes. METHODS: Isolated TBI admissions (>15 years, July 2005-June 2006 were extracted from the hospital discharge datasets for both jurisdictions. Severe isolated TBI (AIS severity >3 admissions were provided by the Trauma Audit and Research Network (TARN and Victorian State Trauma Registry (VSTR for England/Wales, and Victoria, respectively. Multivariable logistic regression was used to compare risk-adjusted mortality between jurisdictions. FINDINGS: Mortality was 12% (749/6256 in England/Wales and 9% (91/1048 in Victoria for isolated TBI admissions. Adjusted odds of death in England/Wales were higher compared to Victoria overall (OR 2.0, 95% CI: 1.6, 2.5, and for cases <65 years (OR 2.36, 95% CI: 1.51, 3.69. For severe TBI, mortality was 23% (133/575 for TARN and 20% (68/346 for VSTR, with 72% of TARN and 86% of VSTR cases managed at a neurosurgical centre. The adjusted mortality odds for severe TBI cases in TARN were higher compared to the VSTR (OR 1.45, 95% CI: 0.96, 2.19, but particularly for cases <65 years (OR 2.04, 95% CI: 1.07, 3.90. Neurosurgical centre management modified the effect overall (OR 1.12, 95% CI: 0.73, 1.74 and for cases <65 years (OR 1.53, 95% CI: 0.77, 3.03. CONCLUSION: The risk-adjusted odds of mortality for all isolated TBI admissions, and severe TBI cases, were higher in England/Wales when compared to Victoria. The lower percentage of cases managed at neurosurgical centres in England and Wales was an explanatory factor, supporting the changes made to the NICE

  18. Modelling the force of infection for hepatitis B and hepatitis C in injecting drug users in England and Wales

    Directory of Open Access Journals (Sweden)

    Hope VD

    2006-06-01

    Full Text Available Abstract Background Injecting drug use is a key risk factor, for several infections of public health importance, especially hepatitis B (HBV and hepatitis C (HCV. In England and Wales, where less than 1% of the population are likely to be injecting drug users (IDUs, approximately 38% of laboratory reports of HBV, and 95% of HCV reports are attributed to injecting drug use. Methods Voluntary unlinked anonymous surveys have been performed on IDUs in contact with specialist agencies throughout England and Wales. Since 1990 more than 20,000 saliva samples from current IDUs have been tested for markers of infection for HBV, HCV testing has been included since 1998. The analysis here considers those IDUs tested for HBV and HCV (n = 5,682 from 1998–2003. This study derives maximum likelihood estimates of the force of infection (the rate at which susceptible IDUs acquire infection for HBV and HCV in the IDU population and their trends over time and injecting career length. The presence of individual heterogeneity of risk behaviour and background HBV prevalence due to routes of transmission other than injecting are also considered. Results For both HBV and HCV, IDUs are at greatest risk from infection in their first year of injecting (Forces of infection in new initiates 1999–2003: HBV = 0.1076 95% C.I: 0.0840–0.1327 HCV = 0.1608 95% C.I: 0.1314–0.1942 compared to experienced IDUs (Force of infection in experienced IDUs 1999–2003: HBV = 0.0353 95% C.I: 0.0198–0.0596, HCV = 0.0526 95% C.I: 0.0310–0.0863 although independently of this there is evidence of heterogeneity of risk behaviour with a small number of IDUs at increased risk of infection. No trends in the FOI over time were detected. There was only limited evidence of background HBV infection due to factors other than injecting. Conclusion The models highlight the need to increase interventions that target new initiates to injecting to reduce the transmission of blood-borne viruses

  19. Exploring experiences of cancer care in Wales: a thematic analysis of free-text responses to the 2013 Wales Cancer Patient Experience Survey (WCPES).

    Science.gov (United States)

    Bracher, Michael; Corner, Dame Jessica; Wagland, Richard

    2016-09-02

    To provide the first systematic analysis of a national (Wales) sample of free-text comments from patients with cancer, to determine emerging themes and insights regarding experiences of cancer care in Wales. Thematic analysis of free-text data from a population-based survey. Adult patients with a confirmed cancer diagnosis treated within a 3-month period during 2012 in the 7 health boards and 1 trust providing cancer care in Wales. Free-text categorised by theme, coded as positive or negative, with ratios. Overarching themes are identified incorporating comment categories. 4672 respondents (of n=7352 survey respondents) provided free-text comments. Data were coded using a multistage approach: (1) coding of comments into general categories (eg, nursing, surgery, etc), (2) coding of subcategories within main categories (eg, nursing care, nursing communication, etc), (3) cross-sectional analysis to identify themes cutting across categories, (4) mapping of categories/subcategories to corresponding closed questions in the Wales Cancer Patient Experience Survey (WCPES) data for comparison. Most free-text respondents (82%, n 3818) provided positive comments about their cancer care, with 49% (n=2313) giving a negative comment (ratio 0.6:1, negative-to-positive). 3172 respondents (67.9% of free-text respondents) provided a comment mapping to 1 of 4 overarching themes: communication (n=1673, 35.8% free-text respondents, a ratio of 1.0:1); waiting during the treatment and/or post-treatment phase (n=923, 19.8%, ratio 1.5:1); staffing and resource levels (n=671, 14.4% ratio 5.3:1); speed and quality of diagnostic care (n=374, 8.0%, ratio 1.5:1). Within these areas, constituent subthemes are discussed. This study presents specific areas of concern for patients with cancer, and reveals a number of themes present across the cancer journey. While the majority of comments were positive, analysis reveals concerns shared by significant numbers of respondents. Timely communication can

  20. The diagnosis of urinary tract infections in young children (DUTY: protocol for a diagnostic and prospective observational study to derive and validate a clinical algorithm for the diagnosis of UTI in children presenting to primary care with an acute illness

    Directory of Open Access Journals (Sweden)

    Downing Harriet

    2012-07-01

    Full Text Available Abstract Background Urinary tract infection (UTI is common in children, and may cause serious illness and recurrent symptoms. However, obtaining a urine sample from young children in primary care is challenging and not feasible for large numbers. Evidence regarding the predictive value of symptoms, signs and urinalysis for UTI in young children is urgently needed to help primary care clinicians better identify children who should be investigated for UTI. This paper describes the protocol for the Diagnosis of Urinary Tract infection in Young children (DUTY study. The overall study aim is to derive and validate a cost-effective clinical algorithm for the diagnosis of UTI in children presenting to primary care acutely unwell. Methods/design DUTY is a multicentre, diagnostic and prospective observational study aiming to recruit at least 7,000 children aged before their fifth birthday, being assessed in primary care for any acute, non-traumatic, illness of ≤ 28 days duration. Urine samples will be obtained from eligible consented children, and data collected on medical history and presenting symptoms and signs. Urine samples will be dipstick tested in general practice and sent for microbiological analysis. All children with culture positive urines and a random sample of children with urine culture results in other, non-positive categories will be followed up to record symptom duration and healthcare resource use. A diagnostic algorithm will be constructed and validated and an economic evaluation conducted. The primary outcome will be a validated diagnostic algorithm using a reference standard of a pure/predominant growth of at least >103, but usually >105 CFU/mL of one, but no more than two uropathogens. We will use logistic regression to identify the clinical predictors (i.e. demographic, medical history, presenting signs and symptoms and urine dipstick analysis results most strongly associated with a positive urine culture result. We will

  1. The diagnosis of urinary tract infections in young children (DUTY): protocol for a diagnostic and prospective observational study to derive and validate a clinical algorithm for the diagnosis of UTI in children presenting to primary care with an acute illness.

    Science.gov (United States)

    Downing, Harriet; Thomas-Jones, Emma; Gal, Micaela; Waldron, Cherry-Ann; Sterne, Jonathan; Hollingworth, William; Hood, Kerenza; Delaney, Brendan; Little, Paul; Howe, Robin; Wootton, Mandy; Macgowan, Alastair; Butler, Christopher C; Hay, Alastair D

    2012-07-19

    Urinary tract infection (UTI) is common in children, and may cause serious illness and recurrent symptoms. However, obtaining a urine sample from young children in primary care is challenging and not feasible for large numbers. Evidence regarding the predictive value of symptoms, signs and urinalysis for UTI in young children is urgently needed to help primary care clinicians better identify children who should be investigated for UTI. This paper describes the protocol for the Diagnosis of Urinary Tract infection in Young children (DUTY) study. The overall study aim is to derive and validate a cost-effective clinical algorithm for the diagnosis of UTI in children presenting to primary care acutely unwell. DUTY is a multicentre, diagnostic and prospective observational study aiming to recruit at least 7,000 children aged before their fifth birthday, being assessed in primary care for any acute, non-traumatic, illness of ≤ 28 days duration. Urine samples will be obtained from eligible consented children, and data collected on medical history and presenting symptoms and signs. Urine samples will be dipstick tested in general practice and sent for microbiological analysis. All children with culture positive urines and a random sample of children with urine culture results in other, non-positive categories will be followed up to record symptom duration and healthcare resource use. A diagnostic algorithm will be constructed and validated and an economic evaluation conducted.The primary outcome will be a validated diagnostic algorithm using a reference standard of a pure/predominant growth of at least >103, but usually >105 CFU/mL of one, but no more than two uropathogens.We will use logistic regression to identify the clinical predictors (i.e. demographic, medical history, presenting signs and symptoms and urine dipstick analysis results) most strongly associated with a positive urine culture result. We will then use economic evaluation to compare the cost

  2. Review of Historic Parishes of England and Wales: An Electronic Map of Boundaries before 1850 with a Gazetteer and Metadata.

    OpenAIRE

    Thomas Pickles

    2002-01-01

    According to the authors, Historic Parishes of England and Wales aims to provide one possible solution to 'a major lacuna militating against the effective exploitation of many post-medieval to mid-Victorian historical sources collected by local administrative areas.' That is 'the lack of information on the boundaries of those administrative areas: the so-called "historic" or "ancient" parishes of England and Wales.' There is no doubt that this is indeed a problem, and that such informatio...

  3. Co-operation and conflict under hard and soft contracting regimes: case studies from England and Wales

    OpenAIRE

    Hughes, David; Allen, Pauline; Doheny, Shane; Petsoulas, Christina; Vincent-Jones, Peter

    2013-01-01

    BACKGROUND: This paper examines NHS secondary care contracting in England and Wales in a period which saw increasing policy divergence between the two systems. At face value, England was making greater use of market levers and utilising harder-edged service contracts incorporating financial penalties and incentives, while Wales was retreating from the 1990 s internal market and emphasising cooperation and flexibility in the contracting process. But there were also cross-border spill-overs inv...

  4. Building Effective Responses: An Independent Review of Violence against Women, Domestic Abuse and Sexual Violence Services in Wales

    OpenAIRE

    Berry, Vashti Louise; Stanley, Nicky; Radford, Lorraine; McCarry, Melanie; Larkins, Cath

    2014-01-01

    Independent researchers from the Connect Centre for International Research on Interpersonal Violence based in the School of Social Work at the University of Central Lancashire were commissioned by the Welsh Government in 2013 to conduct research into violence against women, domestic abuse and sexual violence services in Wales. The research aimed to inform the forthcoming Ending Violence Against Women and Domestic Abuse (Wales) Bill, implementation of the legislation and future policy more gen...

  5. The silviculture, nutrition and economics of short rotation willow coppice in the uplands of mid-Wales

    Energy Technology Data Exchange (ETDEWEB)

    Heaton, R J; Randerson, P F; Slater, F M

    2000-07-01

    The potential of short rotation coppice as a biomass crop on land over 250m (the uplands) of mid Wales was studied. The results found in this study indicate that growing short rotation coppice willow in the uplands is a viable proposition with regard to establishment success and yields. In the event of a secure wood chip market in Wales, returns to the grower would be comparable to those from sheep production. (author)

  6. Germination of native understorey species for revegetation of New South Wales coal mines

    Energy Technology Data Exchange (ETDEWEB)

    Gillespie, M.J.; Bellairs, S.M.; Mulligan, D.R. [University of Queensland, St. Lucia, Qld. (Australia). Dept. of Agriculture and Centre for Mined Land Rehabilitation

    1997-06-01

    This project investigates the suitability of a range of native understorey species for rehabilitation at several coal mines in New South Wales. The germination of seeds from 69 species representing 12 families was tested under controlled laboratory conditions. Germination occurred in all but two of the species tested and 50% germination was exceeded by 29 species. Species of the Mimosaceae, Fabaceae and Proteaceae tended to have above average germination; however species representing other families had variable germination results. A pre-germination heat treatment applied to all of the Acacia species increased germination in some but not all species. Seeds of these understorey species which were used in this trial, are native to the New South Wales coal fields and available commercially or are relatively easy to collect. Glasshouse and field trials are now being undertaken to assess establishment and growth on mine soil, spoil and coal reject materials. 9 refs., 5 figs.

  7. Effect of hydrogen adsorption on the formation and annealing of Stone-Wales defects in graphene

    Science.gov (United States)

    Podlivaev, A. I.; Openov, L. A.

    2015-12-01

    The heights of energy barriers preventing the formation and annealing of Stone-Wales defects in graphene with a hydrogen atom adsorbed on the defect or in its immediate vicinity have been calculated using the atomistic computer simulation. It has been shown that, in the presence of hydrogen, both barriers are significantly lower than those in the absence of hydrogen. Based on the analysis of the potential energy surface, the frequency factors have been calculated for two different paths of the Stone-Wales transformation, and the temperature dependences of the corresponding annealing times of the defects have been found. The results obtained have been compared with the first-principles calculations and molecular dynamics data.

  8. Role of nitrogen distribution in asymmetric stone-wales defects on electronic transport of graphene nanoribbons

    Energy Technology Data Exchange (ETDEWEB)

    Zeng, Hui; Zhao, Jun; Xu, Dahai [College of Physical Science and Technology, Yangtze University, Jingzhou, Hubei 434023 (China); Wei, Jianwei [College of Optoelectronic Information, Chongqing University of Technology, Chongqing 400054 (China)

    2012-01-15

    The authors performed first principles calculation to investigate the influences of nitrogen dopant distribution in the asymmetric Stone-Wales (SW) defect on the electronic transport of zigzag-edged graphene nanoribbon (ZGNR). The stability of doped configurations are evaluated in terms of total energies. It is found that the dopant placed near the edge of the ribbon is the most energetically favorable site. Our results reveal that the doped nanostructures can be substantially modulated as a result of modifications on electronic bands induced by substitutional dopant. Moreover, the individual dopant gives rise to one or two complete electron backscattering centers associated with impurity states in the doped configurations, and the location is determined by the dopant site. Schematics of the atomic structure after asymmetric Stone-Wales defects introduced and different nitrogen substitutional sites. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  9. WRONGFUL TRADING: COMPARATIVE APPROACH (ENGLAND AND WALES, RUSSIA AND THE USA

    Directory of Open Access Journals (Sweden)

    D. Konstantinov

    2015-01-01

    Full Text Available This paper is designed to discover legal rules addressing insolvency trading in three jurisdictions: England and Wales, Russia and the USA. Originally it was a master’s dissertation written under supervision of Ms. Sarah Paterson, who was extremely helpful and patient. The key jurisdiction for the research is England and Wales, whose wrongful trading provision apparently was the very first insolvency regulation in the field. Here, we will give particular attention to the factual circumstances of insolvency trading and research how the concept of wrongful trading addresses them. The next question will be how the American concept of deepening insolvency and the Russian concept of subsidiary liability are comparable with wrongful trading. Later, we will focus on the functions that should be performed by the regulations. Also, the effectiveness of wrongful trading and similar overseas provisions will be examined. Finally, this paper attempts to find obstacles to the wide application of wrongful trading provision.

  10. An Environmental Sector Plan for the nuclear industry in England and Wales

    International Nuclear Information System (INIS)

    Bennett, D.; Fawcett, P.; Hunt, C.; Long, J.

    2004-01-01

    The Environment Agency is the principal environmental regulator in England and Wales. As part of its longer term strategic planning, it is developing 'Sector Plans' for the major industry sectors it regulates. The intent of Sector Plans is to promote improvement of the Industry's performance in order to deliver environmental benefit. One of the pilot Sector Plans developed has been for the nuclear sector. The Nuclear Sector Plan has been produced jointly with the nuclear industry as a rolling framework of agreed national environmental objectives and priorities. Operators of nuclear sites have agreed to use this framework as a basis in England and Wales for setting environmental performance targets, monitoring performance against the targets and publicly reporting on their performance. The paper describes the development of the Sector Plan, its content and further development. (Author) 3 refs

  11. Life expectancy estimation in small administrative areas with non-uniform population sizes: application to Australian New South Wales local government areas.

    Science.gov (United States)

    Stephens, Alexandre S; Purdie, Stuart; Yang, Baohui; Moore, Helen

    2013-12-02

    To determine a practical approach for deriving life expectancy estimates in Australian New South Wales local government areas which display a large diversity in population sizes. Population-based study utilising mortality and estimated residential population data. 153 local government areas in New South Wales, Australia. Key performance measures of Chiang II, Silcocks, adjusted Chiang II and Bayesian random effects model methodologies of life expectancy estimation including agreement analysis of life expectancy estimates and comparison of estimate SEs. Chiang II and Silcocks methods produced almost identical life expectancy estimates across a large range of population sizes but calculation failures and excessively large SEs limited their use in small populations. A population of 25 000 or greater was required to estimate life expectancy with SE of 1 year or less using adjusted Chiang II (a composite of Chiang II and Silcocks methods). Data aggregation offered some remedy for extending the use of adjusted Chiang II in small populations but reduced estimate currency. A recently developed Bayesian random effects model utilising the correlation in mortality rates between genders, age groups and geographical areas markedly improved the precision of life expectancy estimates in small populations. We propose a hybrid approach for the calculation of life expectancy using the Bayesian random effects model in populations of 25 000 or lower permitting the precise derivation of life expectancy in small populations. In populations above 25 000, we propose the use of adjusted Chiang II to guard against violations of spatial correlation, to benefit from a widely accepted method that is simpler to communicate to local health authorities and where its slight inferior performance compared with the Bayesian approach is of minor practical significance.

  12. Natural gas and electricity generation in New South Wales

    International Nuclear Information System (INIS)

    Webb, G.

    2001-01-01

    In its Profile of the Australian Electricity Industry, ABARE noted that NSW was the first State in Australia to unbundle the operations of its State owned electricity industry. The process commenced in 1991, when the Electricity Commission of NSW was renamed Pacific Power and reorganised into six generation and transmission sectors. The power generation fuel mix for NSW in 1999-2000 was as follows: black coal, 97 percent and natural gas, 3 percent. NSW has also imported some brown coal generated electricity from Victoria in recent years. The import of cheap brown coal power from this State due to a marked increase in the availability of brown coal base-load generators in the Latrobe Valley forced some surplus black coal generating capacity in NSW to be withdrawn from the marketplace. Four generating units were closed down in 1998 two 500 MW units at Liddell and two 300 MW units at Munmorah. Further prospects for natural gas are reported to be good; its share in the thermal electricity generation market is forecasted to rise from 3 percent in 1999-2000 to 12 percent in 2014-1015

  13. Measles outbreak linked to European B3 outbreaks, Wales, United Kingdom, 2017.

    Science.gov (United States)

    Currie, Jonny; Davies, Llion; McCarthy, Joanne; Perry, Malorie; Moore, Catherine; Cottrell, Simon; Bowley, Mererid; Williams, Chris; Shankar, Ananda Giri; Stiff, Rhianwen

    2017-10-01

    The United Kingdom achieved interrupted endemic measles transmission for 36 months in 2016. Despite this, ongoing challenges from sporadic measles cases typically imported from abroad remain. We summarise a B3 measles genotype outbreak in south-east Wales occurring between May and September 2017, linked with other European outbreaks, and lessons learnt. Seventeen confirmed cases and one probable case occurred principally in education and healthcare-settings. Six confirmed cases attended healthcare settings when infectious, without being isolated.

  14. Prayer, personality and happiness: a study among undergraduate students in Wales

    OpenAIRE

    Robbins, Mandy; Francis, Leslie J.; Edwards, Bethan

    2008-01-01

    In order to examine the association between prayer and happiness, a sample of 131 undergraduate students attending a university in Wales completed three measures: the Oxford Happiness Questionnaire, the abbreviated Eysenck Personality Questionnaire Revised, and prayer frequency assessed on a 5-point scale. The data demonstrated a significant positive correlation between prayer frequency and happiness before controlling for individual differences in personality. After controlling for personali...

  15. Who should do the dishes now? Revisiting gender and housework in contemporary urban South Wales

    OpenAIRE

    Mannay, Dawn

    2016-01-01

    This chapter revisits Jane Pilcher’s (1994) seminal work ‘Who should do the dishes? Three generations of Welsh women talking about men and housework’, which was originally published in Our Sister’s Land: the changing identities of women in Wales. As discussed in the introductory chapter, I began revisiting classic Welsh studies as part of my doctoral study Mothers and daughters on the margins: gender, generation and education (Mannay, 2012); this lead to the later publication of a revisiting ...

  16. Anisotropic mechanical properties and Stone-Wales defects in graphene monolayer: A theoretical study

    International Nuclear Information System (INIS)

    Fan, B.B.; Yang, X.B.; Zhang, R.

    2010-01-01

    We investigate the mechanical properties of graphene monolayer via the density functional theoretical (DFT) method. We find that the strain energies are anisotropic for the graphene under large strain. We attribute the anisotropic feature to the anisotropic sp 2 hybridization in the hexagonal lattice. We further identify that the formation energies of Stone-Wales (SW) defects in the graphene monolayer are determined by the defect concentration and also the direction of applied tensile strain, correlating with the anisotropic feature.

  17. Murrumbidgee Catchment, New South Wales: Recharge Trading and Targeting Markets pilot studies

    OpenAIRE

    Markets for Ecosystem Services Project

    2007-01-01

    Metadata only record There are two 'markets for ecosystem services' pilot studies in the Murrumbidgee Catchment of New South Wales, Australia. The first, "Recharge Trading", aims to develop a market-based instrument to resolve the issue of salinization caused by excess groundwater recharge from irrigated agriculture. The second, "Targeting Markets", explores the factors and conditions that make market-based approaches more or less suitable for addressing a natural resource management issue...

  18. Electing police and crime commissioners in England and Wales, 2012 as second-order elections

    OpenAIRE

    Johnston, R.; Pattie, C.

    2014-01-01

    The first elections to the newly created 41 posts of Police and Crime Commissioner in England and Wales were held in November 2012. The results show all the main characteristics of second-order elections. Turnout was low. The two unpopular coalition parties in the national government lost vote share compared to the outcome of the most recent general election, whereas the main opposition party's share increased substantially-as did that of a minor party (UKIP). Labour, Liberal Democrat and UKI...

  19. A survey of local health promotion initiatives for older people in Wales

    Directory of Open Access Journals (Sweden)

    Williams Nefyn H

    2008-06-01

    Full Text Available Abstract Background As the demographic profile of the UK changes, policy makers and practitioners have to respond to health challenges presented by a progressively ageing population. The health promotion plan for older people, aged over 50 years, in Wales included eight key areas: physical activity, healthy eating, home safety and warmth, emotional health, health protection, smoking, alcohol and sexual health. The aim of this study was to describe the extent, content and regional variation of existing health promotion initiatives for older people in Wales, provided by statutory, voluntary and private sector agencies. Method A questionnaire was sent to senior health promotion specialists employed in the 22 local authority areas in Wales to ascertain details of all projects promoting health and wellbeing in the eight key areas where the priority population was aged over 50, or the majority of users were older people. Additional information was sought from project leads and websites. Results Eighteen questionnaires were returned; not all were fully completed. Four areas did not return a questionnaire. Additional information was obtained from internet searches but this mainly concerned national initiatives rather than local projects. In all, 120 projects were included, 11 were throughout Wales. Best provision was for physical activity, with 3 national and 42 local initiatives, but local provision was patchy. Healthy eating, and home safety and warmth had far fewer initiatives, as did health protection, which comprised two national immunisation campaigns. Smoking and alcohol misuse were poorly provided for, and there was no provision for older people's sexual health. Evaluation arrangements were poorly described. Half of those who responded identified unmet training needs. Conclusion The reasons for patchy provision of services were not clear. Increased efforts to improve the coverage of interventions known to be effective should be made. Rigorous

  20. Scum cuddlers:police and the sex offenders’ register in England and Wales

    OpenAIRE

    Nash, Mike

    2014-01-01

    Police in England and Wales have been given an increasingly important role in community offender management. In many ways removed from what might be regarded as ‘real’ police work, it has nonetheless become a standard way of working for large numbers of police officers. An aspect of this work has brought the police into much closer and lasting professional contact with sex offenders as a result of new responsibilities given them under the Sexual Offenders Act, 1997. This article will discuss ...

  1. International trends in health science librarianship Part 9: the UK - Scotland and Wales.

    Science.gov (United States)

    Wales, Ann; Bruch, Sarah; Foster, Wendy; Gorman, Meg; Peters, Janet

    2014-03-01

    This is the 9th in a series of articles exploring international trends in health science librarianship. The previous article in this series looked at Northern Ireland and the Republic of Ireland. In this issue the focus is Scotland and Wales. There will be three or four more articles this year tracking trends in the Far East, Africa, South Asia and the Middle East. JM. © 2014 The authors. Health Information and Libraries Journal © 2014 Health Libraries Group.

  2. AN ANALYSIS OF MISCONCEPTIONS IN SCIENCE TEXTBOOKS: EARTH SCIENCE IN ENGLAND AND WALES

    OpenAIRE

    King , Chris John Henry

    2010-01-01

    Abstract Surveys of the earth science content of all secondary (high school) science textbooks and related publications used in England and Wales have revealed high levels of error/ misconception. The 29 science textbooks or textbook series surveyed (51 texts in all) showed poor coverage of National Curriculum earth science and contained a mean level of one earth science error/ misconception per page. Science syllabuses and examinations surveyed also showed errors/ misconceptions. ...

  3. Hospital Outpatient Prospective Payment System (OPPS) Lim...

    Data.gov (United States)

    U.S. Department of Health & Human Services — Hospital Outpatient Prospective Payment System (OPPS) Limited Data Set This file contains select claim level data and is derived from 2010 hospital outpatient PPS...

  4. Greenhouse gas inventories for England, Scotland, Wales and Northern Ireland: 1990 and 1995. A scoping study

    Energy Technology Data Exchange (ETDEWEB)

    Salway, A.G.; Dore, C.; Watterson, J.; Murrells, T.

    1999-11-01

    This report presents the results of a scoping study to develop a methodology to produce desegregated greenhouse gas emission inventories for the devoved administrations of the UK. Separate greenhouse gas emission inventories were estimated for England, Scotland, Wales and Northern Ireland for the years 1990 and 1995. The gases reported are carbon dioxide, methane, nitrous oxide, hydrofluorocarbons, perfluorocarbons, and SF{sub 6}. The estimates are consistent with the 1997 UK Greenhouse Gas Inventory and hence the UNFCCC reporting guidelines. Some emissions mainly mobile and offshore sources could not be allocated to any region, so an extra unallocated category was used to report these. Where possible the same methodology was used to calculate the regional emissions as for the UK Inventory. The study showed that the distribution of regional greenhouse gas emissions expressed as global warming potentials in 1995 were: England 75.5%, Scotland, 11.4%; Wales 6.4%; Northern Ireland 3.1%: unallocated, 4%. Following this scoping study, it is intended to publish annually disaggregated inventories for each year from 1990 for England, Scotland, Wales and Northern Ireland, in addition to the UK Greenhouse Gas Inventory. 50 refs., 6 figs., 16 tabs., 2 apps.

  5. Demographic factors associated with smoking cessation during pregnancy in New South Wales, Australia, 2000-2011.

    Science.gov (United States)

    Passmore, Erin; McGuire, Rhydwyn; Correll, Patricia; Bentley, Jason

    2015-04-18

    Smoking during pregnancy increases the risk of adverse health outcomes for both the mother and the child. Rates of smoking during pregnancy, and rates of smoking cessation during pregnancy, vary between demographic groups. This study describes demographic factors associated with smoking cessation during pregnancy in New South Wales, Australia, and describes trends in smoking cessation in demographic subgroups over the period 2000 - 2011. Data were obtained from the New South Wales Perinatal Data Collection, a population-based surveillance system covering all births in New South Wales. Multivariate logistic regression was used to explore associations between smoking cessation during pregnancy and demographic factors. Between 2000 and 2011, rates of smoking cessation in pregnancy increased from 4.0% to 25.2%. Demographic characteristics associated with lower rates of smoking cessation during pregnancy included being a teenage mother, being an Aboriginal person, and having a higher number of previous pregnancies. Between 2000 and 2011, rates of smoking cessation during pregnancy increased dramatically across all demographic groups. However, specific demographic groups remain significantly less likely to quit smoking, suggesting a need for targeted efforts to promote smoking cessation in these groups.

  6. Public value at risk from Phytophthora ramorum and Phytophthora kernoviae spread in England and Wales.

    Science.gov (United States)

    Drake, Ben; Jones, Glyn

    2017-04-15

    Heritage gardens, heathland and woodland are increasingly under threat from the non-native tree and plant diseases Phytophthora ramorum and Phytophthora kernoviae. However, there exist only limited literature that estimates the public non-market value that may be lost from a continued spread of Phytophthora ramorum and Phytophthora kernoviae into these habitats. This paper therefore uses a contingent valuation survey to assess the non-extractive public use and non-use values at risk from an uncontrolled spread of these diseases in England and Wales. Results estimate that £1.446bn of public value is at risk in England and Wales per year from an uncontrolled spread of Phytophthora ramorum and Phytophthora kernoviae. The greatest public value at risk, of £578  m/year, is from an uncontrolled spread of these diseases to heritage gardens, while the lowest public value at risk, of £386  m/year, is from disease spread to heathland. The findings of this paper should help policymakers make informed decisions as to the public resources to dedicate towards Phytophthora ramorum and Phytophthora kernoviae control in England and Wales. In this regard, the current control programme to contain these diseases appears cost-effective in light of the public value at risk estimates produced by this paper. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Status of eel fisheries, stocks and their management in England and Wales

    Directory of Open Access Journals (Sweden)

    Aprahamian M.

    2009-05-01

    Full Text Available All continental life stages of eel are exploited in England and Wales. The main fisheries for glass eel are by estuarine dip-nets in the southwest. The main fisheries for yellow and silver eel occur in southern and eastern England, with fyke nets being the preferred instrument. Fishing effort is not directly recorded but is inferred from licence sales. Around 1100 glass eel licenses were sold annually from 1980 to 1994, increasing to around 2500 in 1998, but declined to about 800 per annum since 2001. Declared catches of glass eel have been below 1–2 t since 2001, compared to 10–70 t in the 1970s and 1980s. Licence sales for yellow and silver eel fisheries (combined varied from around 1100 to 2900 over the period 1983–2007, peaking in the mid-1980s, mid-1990s and again in 2005–2007. Declared catches peaked in the late 1980s and mid-1990s (peak 280 t, but have been low since 2001 (mean 29 t. Nett export data suggests catches may be 4 times higher. Eel landings are reported as bycatch from various marine fisheries around the UK coasts, with landings from 2001 to 2007 ranging from 0.2 to 13.7 t per annum. Assessment of stock status is based mainly on catch and catch per unit effort data as there has been little fishery independent survey of eels. There has been a general decreasing trend in both glass eel catches reported to the Agency and in nett export data. Comparing maximum catch levels in the late 1970s–early 1980s with minimum levels in the 2000s suggests that the catch has declined by around 75–95%. Trends in CPUE are similar, at least until 1998. It is concluded that current glass eel recruitment to the western coast of the UK is approximately 30% of the pre-1980 level of recruitment. Yellow and silver eel indices derived from HMRC nett exports or reported catches per licence sold, both suggest that the current estimate of stocks derived from these data are 20% those of the late 1980s and mid 1990s. The Reference Condition

  8. Korea prospects

    International Nuclear Information System (INIS)

    Wyman, V.

    1990-01-01

    Contacts between the South Korean nuclear industry and a combined United Kingdom mission representing AEA Technology and British Nuclear Fuels Limited (BNFL) are reported. Prospects for entering the Korean market in two areas are perceived. The first is waste management and the second is the Safe Integral Reactor (SIR), an advanced pressurized water reactor design. AEA Technology and three collaborators have been promoting SIR as an inherently safe reactor design. Korean interest could be expressed in financial backing for the building of SIR stations in Korea and the opportunity could arise for BNFL to win fuel supply contracts. (UK)

  9. Proposals for the Radioactive Substances (Basic Safety Standards) (England and Wales) Regulations 2000 and the Radioactive Substances (Basic Safety Standards) (England and Wales) Direction 2000. Consultative document

    International Nuclear Information System (INIS)

    2000-01-01

    This document contains proposals for changes to the Radioactive Substances Act 1993 (RSA 93) and proposals for a Direction to be given to the Environment Agency in order to implement aspects of the European Directive 96/29/Euratom concerned with the control of radioactive waste. The Directive lays down basic safety standards for the protection of the health of workers and the general public against the dangers arising from ionising radiation. With the Government pledged to making government more accessible and responsive, an important feature of this approach is effective consultation with all interested organisations. This leads to more realistic and robust proposals, which is particularly important when dealing with proposed legislation. In March this year, the Government published a consultation paper 'The Radioactive Substances Act 1993: Implementing the Revised Basic Safety Standards Directive Euratom 96/29.' This sought comments on the basic principles for change - including the setting of levels of radioactivity below which radioactive material should be considered outside the framework of regulatory control. This document forms the second stage of the consultation process with the aim of gathering views on the proposed legal instruments to implement the Directive. This document: explains the background to the proposed regulations (paragraphs 8-13); summarises the results of the consultation on principles (paragraphs 14-24); describes the proposed changes (paragraphs 25-36); includes draft Regulations (paragraphs 27-29); includes a draft Direction to the Environment Agency (paragraphs 30-36); describes the next steps (paragraphs 37-39); includes a draft Regulatory Impact Assessment (paragraphs 40-41). In general, the devolved administrations in Scotland, Wales and Northern Ireland have assumed responsibility for environmental issues and hence management of radioactive waste policies and legislation affecting their respective countries. However, this

  10. Historic air pollution exposure and long-term mortality risks in England and Wales: prospective longitudinal cohort study.

    Science.gov (United States)

    Hansell, Anna; Ghosh, Rebecca E; Blangiardo, Marta; Perkins, Chloe; Vienneau, Danielle; Goffe, Kayoung; Briggs, David; Gulliver, John

    2016-04-01

    Long-term air pollution exposure contributes to mortality but there are few studies examining effects of very long-term (>25 years) exposures. This study investigated modelled air pollution concentrations at residence for 1971, 1981, 1991 (black smoke (BS) and SO2) and 2001 (PM10) in relation to mortality up to 2009 in 367,658 members of the longitudinal survey, a 1% sample of the English Census. Outcomes were all-cause (excluding accidents), cardiovascular (CV) and respiratory mortality. BS and SO2 exposures remained associated with mortality decades after exposure-BS exposure in 1971 was significantly associated with all-cause (OR 1.02 (95% CI 1.01 to 1.04)) and respiratory (OR 1.05 (95% CI 1.01 to 1.09)) mortality in 2002-2009 (ORs expressed per 10 μg/m(3)). Largest effect sizes were seen for more recent exposures and for respiratory disease. PM10 exposure in 2001 was associated with all outcomes in 2002-2009 with stronger associations for respiratory (OR 1.22 (95% CI 1.04 to 1.44)) than CV mortality (OR 1.12 (95% CI 1.01 to 1.25)). Adjusting PM10 for past BS and SO2 exposures in 1971, 1981 and 1991 reduced the all-cause OR to 1.16 (95% CI 1.07 to 1.26) while CV and respiratory associations lost significance, suggesting confounding by past air pollution exposure, but there was no evidence for effect modification. Limitations include limited information on confounding by smoking and exposure misclassification of historic exposures. This large national study suggests that air pollution exposure has long-term effects on mortality that persist decades after exposure, and that historic air pollution exposures influence current estimates of associations between air pollution and mortality. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  11. Development of risk-based trading farm scoring system to assist with the control of bovine tuberculosis in cattle in England and Wales.

    Science.gov (United States)

    Adkin, A; Brouwer, A; Simons, R R L; Smith, R P; Arnold, M E; Broughan, J; Kosmider, R; Downs, S H

    2016-01-01

    Identifying and ranking cattle herds with a higher risk of being or becoming infected on known risk factors can help target farm biosecurity, surveillance schemes and reduce spread through animal trading. This paper describes a quantitative approach to develop risk scores, based on the probability of infection in a herd with bovine tuberculosis (bTB), to be used in a risk-based trading (RBT) scheme in England and Wales. To produce a practical scoring system the risk factors included need to be simple and quick to understand, sufficiently informative and derived from centralised national databases to enable verification and assess compliance. A logistic regression identified herd history of bTB, local bTB prevalence, herd size and movements of animals onto farms in batches from high risk areas as being significantly associated with the probability of bTB infection on farm. Risk factors were assigned points using the estimated odds ratios to weight them. The farm risk score was defined as the sum of these individual points yielding a range from 1 to 5 and was calculated for each cattle farm that was trading animals in England and Wales at the start of a year. Within 12 months, of those farms tested, 30.3% of score 5 farms had a breakdown (sensitivity). Of farms scoring 1-4 only 5.4% incurred a breakdown (1-specificity). The use of this risk scoring system within RBT has the potential to reduce infected cattle movements; however, there are cost implications in ensuring that the information underpinning any system is accurate and up to date. Crown Copyright © 2015. Published by Elsevier B.V. All rights reserved.

  12. Mortality attributable to excess adiposity in England and Wales in 2003 and 2015: explorations with a spreadsheet implementation of the Comparative Risk Assessment methodology

    Directory of Open Access Journals (Sweden)

    Powles John W

    2009-06-01

    Full Text Available Abstract Background Our aim was to estimate the burden of fatal disease attributable to excess adiposity in England and Wales in 2003 and 2015 and to explore the sensitivity of the estimates to the assumptions and methods used. Methods A spreadsheet implementation of the World Health Organization's (WHO Comparative Risk Assessment (CRA methodology for continuously distributed exposures was used. For our base case, adiposity-related risks were assumed to be minimal with a mean (SD BMI of 21 (1 Kg m-2. All cause mortality risks for 2015 were taken from the Government Actuary and alternative compositions by cause derived. Disease-specific relative risks by BMI were taken from the CRA project and varied in sensitivity analyses. Results Under base case methods and assumptions for 2003, approximately 41,000 deaths and a loss of 1.05 years of life expectancy were attributed to excess adiposity. Seventy-seven percent of all diabetic deaths, 23% of all ischaemic heart disease deaths and 14% of all cerebrovascular disease deaths were attributed to excess adiposity. Predictions for 2015 were found to be more sensitive to assumptions about the future course of mortality risks for diabetes than to variation in the assumed trend in BMI. On less favourable assumptions the attributable loss of life expectancy in 2015 would rise modestly to 1.28 years. Conclusion Excess adiposity appears to contribute materially but modestly to mortality risks in England and Wales and this contribution is likely to increase in the future. Uncertainty centres on future trends of associated diseases, especially diabetes. The robustness of these estimates is limited by the lack of control for correlated risks by stratification and by the empirical uncertainty surrounding the effects of prolonged excess adiposity beginning in adolescence.

  13. Mortality attributable to excess adiposity in England and Wales in 2003 and 2015: explorations with a spreadsheet implementation of the Comparative Risk Assessment methodology.

    Science.gov (United States)

    Kelly, Christopher; Pashayan, Nora; Munisamy, Sreetharan; Powles, John W

    2009-06-30

    Our aim was to estimate the burden of fatal disease attributable to excess adiposity in England and Wales in 2003 and 2015 and to explore the sensitivity of the estimates to the assumptions and methods used. A spreadsheet implementation of the World Health Organization's (WHO) Comparative Risk Assessment (CRA) methodology for continuously distributed exposures was used. For our base case, adiposity-related risks were assumed to be minimal with a mean (SD) BMI of 21 (1) Kg m-2. All cause mortality risks for 2015 were taken from the Government Actuary and alternative compositions by cause derived. Disease-specific relative risks by BMI were taken from the CRA project and varied in sensitivity analyses. Under base case methods and assumptions for 2003, approximately 41,000 deaths and a loss of 1.05 years of life expectancy were attributed to excess adiposity. Seventy-seven percent of all diabetic deaths, 23% of all ischaemic heart disease deaths and 14% of all cerebrovascular disease deaths were attributed to excess adiposity. Predictions for 2015 were found to be more sensitive to assumptions about the future course of mortality risks for diabetes than to variation in the assumed trend in BMI. On less favourable assumptions the attributable loss of life expectancy in 2015 would rise modestly to 1.28 years. Excess adiposity appears to contribute materially but modestly to mortality risks in England and Wales and this contribution is likely to increase in the future. Uncertainty centres on future trends of associated diseases, especially diabetes. The robustness of these estimates is limited by the lack of control for correlated risks by stratification and by the empirical uncertainty surrounding the effects of prolonged excess adiposity beginning in adolescence.

  14. Energy prospects

    International Nuclear Information System (INIS)

    Lyall, K.

    1991-01-01

    The Business Council of Australia's study on Prospects for Improved Energy Efficiency and the Application of Renewable Energy Resources is summarised. The study estimates that replacement of all off-peak electric units in Australia with solar gas boosted systems would reduce electricity consumption for residential water heating by approximately 25% and almost halve carbon dioxide emissions resulting from residential water heating. Furthermore, substitution of all water heating units in Australia with solar gas systems would reduce total emissions by about 80%. The study concludes that while substitution on such a scale could not readily be achieved even within several decades, the estimates do indicate the significant benefits that might be realised by a long term program. 2 refs., 3 tabs

  15. A contemporary risk model for predicting 30-day mortality following percutaneous coronary intervention in England and Wales.

    Science.gov (United States)

    McAllister, Katherine S L; Ludman, Peter F; Hulme, William; de Belder, Mark A; Stables, Rodney; Chowdhary, Saqib; Mamas, Mamas A; Sperrin, Matthew; Buchan, Iain E

    2016-05-01

    The current risk model for percutaneous coronary intervention (PCI) in the UK is based on outcomes of patients treated in a different era of interventional cardiology. This study aimed to create a new model, based on a contemporary cohort of PCI treated patients, which would: predict 30 day mortality; provide good discrimination; and be well calibrated across a broad risk-spectrum. The model was derived from a training dataset of 336,433 PCI cases carried out between 2007 and 2011 in England and Wales, with 30 day mortality provided by record linkage. Candidate variables were selected on the basis of clinical consensus and data quality. Procedures in 2012 were used to perform temporal validation of the model. The strongest predictors of 30-day mortality were: cardiogenic shock; dialysis; and the indication for PCI and the degree of urgency with which it was performed. The model had an area under the receiver operator characteristic curve of 0.85 on the training data and 0.86 on validation. Calibration plots indicated a good model fit on development which was maintained on validation. We have created a contemporary model for PCI that encompasses a range of clinical risk, from stable elective PCI to emergency primary PCI and cardiogenic shock. The model is easy to apply and based on data reported in national registries. It has a high degree of discrimination and is well calibrated across the risk spectrum. The examination of key outcomes in PCI audit can be improved with this risk-adjusted model. Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

  16. Benefit Cost Analysis of Three Skin Cancer Public Education Mass-Media Campaigns Implemented in New South Wales, Australia.

    Science.gov (United States)

    Doran, Christopher M; Ling, Rod; Byrnes, Joshua; Crane, Melanie; Shakeshaft, Anthony P; Searles, Andrew; Perez, Donna

    2016-01-01

    Public education mass media campaigns are an important intervention for influencing behaviour modifications. However, evidence on the effectiveness of such campaigns to encourage the population to reduce sun exposure is limited. This study investigates the benefits and costs of three skin cancer campaigns implemented in New South Wales from 2006-2013. This analysis uses Australian dollars (AUD) and 2010-11 as the currency and base year, respectively. Historical data on skin cancer were used to project skin cancer rates for the period 2006-2020. The expected number of skin cancer cases is derived by combining skin cancer rates, sunburn rates and relative risk of skin cancers due to sun exposure. Counterfactual estimates are based on sunburn exposure in the absence of the campaigns. Monetary values are attached to direct (treatment) and indirect (productivity) costs saved due to fewer skin cancer cases. Monetary benefits are compared with the cost of implementing the campaigns and are presented in the form of a benefit-cost ratio. Relative to the counterfactual (i.e., no campaigns) there are an estimated 13,174 fewer skin cancers and 112 averted deaths over the period 2006-2013. The net present value of these benefits is $60.17 million and the campaign cost is $15.63 million. The benefit cost ratio is 3.85, suggesting that for every $1 invested a return of $3.85 is achieved. Skin cancer public education mass media campaigns are a good investment given the likely extent to which they reduce the morbidity, mortality and economic burden of skin cancer.

  17. What choices should we be able to make about designer babies? A Citizens’ Jury of young people in South Wales

    Science.gov (United States)

    Iredale, Rachel; Longley, Marcus; Thomas, Christian; Shaw, Anita

    2006-01-01

    Abstract Background  Young people will increasingly have the option of using new technologies for reproductive decision making but their voices are rarely heard in debates about acceptable public policy in this area. Capturing the views of young people about potentially esoteric topics, such as genetics, is difficult and methodologically challenging. Design  A Citizens’ Jury is a deliberative process that presents a question to a group of ordinary people, allows them to examine evidence given by expert witnesses and personal testimonies and arrive at a verdict. This Citizens’ Jury explored designer babies in relation to inherited conditions, saviour siblings and sex selection with young people. Participants  Fourteen young people aged 16–19 in Wales. Results  Acceptance of designer baby technology was purpose‐specific; it was perceived by participants to be acceptable for preventing inherited conditions and to create a child to save a sibling, but was not recommended for sex selection. Jurors stated that permission should not depend on parents’ age, although some measure of suitability should be assessed. Preventing potential parents from going abroad was considered impractical. These young people felt the Human Fertilisation and Embryology Authority should have members under 20 and that the term ‘designer baby’ was not useful. Conclusions  Perspectives on the acceptability of this technology were nuanced, and based on implicit value judgements about the extent of individual benefit derived. Young people have valuable and interesting contributions to make to the debate about genetics and reproductive decision making and a variety of innovative methods must be used to secure their involvement in decision‐making processes. PMID:16911135

  18. Benefit Cost Analysis of Three Skin Cancer Public Education Mass-Media Campaigns Implemented in New South Wales, Australia

    Science.gov (United States)

    2016-01-01

    Public education mass media campaigns are an important intervention for influencing behaviour modifications. However, evidence on the effectiveness of such campaigns to encourage the population to reduce sun exposure is limited. This study investigates the benefits and costs of three skin cancer campaigns implemented in New South Wales from 2006–2013. This analysis uses Australian dollars (AUD) and 2010–11 as the currency and base year, respectively. Historical data on skin cancer were used to project skin cancer rates for the period 2006–2020. The expected number of skin cancer cases is derived by combining skin cancer rates, sunburn rates and relative risk of skin cancers due to sun exposure. Counterfactual estimates are based on sunburn exposure in the absence of the campaigns. Monetary values are attached to direct (treatment) and indirect (productivity) costs saved due to fewer skin cancer cases. Monetary benefits are compared with the cost of implementing the campaigns and are presented in the form of a benefit-cost ratio. Relative to the counterfactual (i.e., no campaigns) there are an estimated 13,174 fewer skin cancers and 112 averted deaths over the period 2006–2013. The net present value of these benefits is $60.17 million and the campaign cost is $15.63 million. The benefit cost ratio is 3.85, suggesting that for every $1 invested a return of $3.85 is achieved. Skin cancer public education mass media campaigns are a good investment given the likely extent to which they reduce the morbidity, mortality and economic burden of skin cancer. PMID:26824695

  19. Electronic properties of graphene with single vacancy and Stone-Wales defects

    International Nuclear Information System (INIS)

    Zaminpayma, Esmaeil; Razavi, Mohsen Emami; Nayebi, Payman

    2017-01-01

    Highlights: • The electronic properties of graphene device with single vacancy (SV) and Stone-Wales (SW) defect have been studied. • The first principles calculations have been performed based on self-consistent charge density functional tight-binding. • The density of state, current voltage curves of pure graphene and graphene with SV and SW defects have been investigated. • Transmission spectrum of pristine graphene device and graphene with SV and SW defects has been examined. - Abstract: The first principles calculations have been performed based on self-consistent charge density functional tight-binding in order to examine the electronic properties of graphene with single vacancy (SV) and Stone-Wales (SW) defects. We have optimized structures of pristine graphene and graphene with SV and SW defects. The bond lengths, current-voltage curve and transmission probability have been calculated. We found that the bond length for relaxed graphene is 1.43 Å while for graphene with SV and SW defects the bond lengths are 1.41 Å and 1.33 Å, respectively. For the SV defect, the arrangement of atoms with three nearest neighbors indicates sp_2 bonding. While for SW defect, the arrangement of atoms suggests nearly sp bonding. From the current-voltage curve for graphene with defects we have determined that the behavior of the I–V curves is nonlinear. It is also found that the SV and SW defects cause to decrease the current compared to the pristine graphene case. Furthermore, the single vacancy defect reduces the current more than the Stone-Wales defect. Moreover, we observed that by increasing the voltage from zero to 1 V new peaks near Fermi level in the transmission probability curves have been created.

  20. The Incidence of Thyroid Cancer in England and Wales over A Ten-Year Period

    Directory of Open Access Journals (Sweden)

    Louise Marie Evans

    2017-04-01

    Full Text Available Introduction The incidence of thyroid cancer has increased worldwide, whether a real or apparent increase is debated. Literature from the USA suggests greater diagnostic scrutiny, environmental and genetic factors may all play a part. This increase will result in a greater number of referrals for surgical assessment. This study examined the trend in incidence of thyroid cancer in England and Wales. Materials and Methods A retrospective study, using the HES database over the period 2000-2010. Data were extracted of all newly diagnosed thyroid cancers in England and Wales and the age at diagnosis. Data were examined for the change in incidence of thyroid cancer diagnosis dependent on the age group of the patient using the linear regression model. Results 45411 patients were identified. In England the incidence of thyroid cancer rose from 5.7/100,000 of the population in 2000 to 9.9/100,000 in 2010 and in Wales it rose from 3.5/100,000 in 2000 to 7.5/100,000. There was a statistical increase (P≤0.02 (t-stat >2 in the diagnosis of thyroid cancers across all age groups with exception of the 0-14 age group (P>0.5.  Conclusion There has been a statistical increase in the incidence of thyroid cancer. This is likely to impact on hospitals and cancer service resources. An increase in surgical demand and the coinciding ageing population highlights the importance of further investigation into the etiology, use of imaging, patient demographics, histology and overall mortality of this patient group.

  1. Culture care of Iranian immigrants in New South Wales, Australia: sharing transcultural nursing knowledge.

    Science.gov (United States)

    Omeri, A

    1997-01-01

    Discovery and analysis of care meanings, expressions, and practices of Iranian Immigrants in New South Wales, Australia was the focus of this ethnonursing qualitative research. The purpose of the study was to systematically discover, describe and analyse the values, beliefs, and practices of Iranian immigrants in New South Wales, Australia. The aim of the investigation was to discover transcultural nursing knowledge to guide nurses and health professionals to provide culturally congruent nursing and health care to Iranians. Leininger's theory of Culture Care Diversity and Universality (Leininger, 1991) was used as the conceptual framework for the study. It was predicted that care meanings and expressions of Iranian immigrants would be influenced by their worldview, social structure features, language, and cultural values rooted in their long ethnohistorical past and reflected in their lifeways in Australia. Using the ethnonursing qualitative research method, key and general informants were purposefully selected among Iranian immigrants residing in New South Wales. Three care themes supported by a number of universal and some diverse patterns were identified for Iranian immigrants. The three themes were: (1) Care meant family and kinship ties (hambastegie) as expressed in daily lifeways and interactions with family, friends, and community; (2) Care as expressed in carrying out traditional urban gender roles (role-zan-o-mard) (Azadie zan) as well as in fulfilling emerging new role responsibilities related to equality for female Iranian immigrants; and (3) Care as preservation of Iranian identity (inhamoni, hamonandi) as expressed in traditional cultural events and health care practices. Leininger's (1991) three modes of actions and decisions were used to develop appropriate and culturally meaningful nursing care actions and decisions which were in harmony with the cultural beliefs of Iranian immigrants.

  2. Control of a community outbreak of hepatitis A in an area of low endemicity, Wales, 2016.

    Science.gov (United States)

    Vaz, J; Floyd, C; Mason, B; Shankar, A G; Lewis, H

    2017-10-03

    Incidence of hepatitis A in Wales is low (average of 0.48/100,000 inhabitants from 2004-2015). We describe a community outbreak of hepatitis A involving 3 schools (primary and secondary) in South Wales between March and June 2016 and reflect on the adequacy of the control measures used. Anyone in South Wales epidemiologically linked to a serological and/or RNA positive confirmed case of hepatitis A during the 15-50 d before onset of symptoms (diarrhea, vomiting, fever, nausea, AND jaundice, or jaundice-associated symptom) was defined as a case. Case identification was based on laboratory or GP suspicion notification, changing to active surveillance toward the end. As per national guidance, household contacts were identified and offered immunisation while in schools vaccination followed evidence of transmission. We went beyond guidance by vaccinating street play mates and in secondary schools. Mass vaccination uptake was calculated. There were 17 cases, mostly in children under 16 y of age. All cases had an epidemiological link to either a school or a household case (except primary) and no travel history. Street playing was the only epidemiological link between 2 cases in different schools. A total of 139 household contacts were identified. All schools, including secondary one, had a transmission event preceding mass vaccination (overall uptake 85%, reaching 1,574 individuals) and no tertiary cases emerged after the campaigns. We recommend extending guidance to include actions taken that helped curb this outbreak: 1) vaccinating in secondary school and 2) broadening the household contact definition. Based on our learning we further suggest 3) vaccinating upon identification of a single case who attended school while infectious regardless of source and 4) active case finding by serologically testing contacts.

  3. Electronic properties of graphene with single vacancy and Stone-Wales defects

    Energy Technology Data Exchange (ETDEWEB)

    Zaminpayma, Esmaeil [Physics Group, Qazvin Branch, Islamic Azad University, Qazvin (Iran, Islamic Republic of); Razavi, Mohsen Emami, E-mail: razavi246@gmail.com [Plasma Physics Research Center, Science and Research Branch, Islamic Azad University, P.O. Box 14665-678, Tehran (Iran, Islamic Republic of); Nayebi, Payman [Department of Physics, College of Technical and Engineering, Saveh Branch, Islamic Azad University, Saveh (Iran, Islamic Republic of)

    2017-08-31

    Highlights: • The electronic properties of graphene device with single vacancy (SV) and Stone-Wales (SW) defect have been studied. • The first principles calculations have been performed based on self-consistent charge density functional tight-binding. • The density of state, current voltage curves of pure graphene and graphene with SV and SW defects have been investigated. • Transmission spectrum of pristine graphene device and graphene with SV and SW defects has been examined. - Abstract: The first principles calculations have been performed based on self-consistent charge density functional tight-binding in order to examine the electronic properties of graphene with single vacancy (SV) and Stone-Wales (SW) defects. We have optimized structures of pristine graphene and graphene with SV and SW defects. The bond lengths, current-voltage curve and transmission probability have been calculated. We found that the bond length for relaxed graphene is 1.43 Å while for graphene with SV and SW defects the bond lengths are 1.41 Å and 1.33 Å, respectively. For the SV defect, the arrangement of atoms with three nearest neighbors indicates sp{sub 2} bonding. While for SW defect, the arrangement of atoms suggests nearly sp bonding. From the current-voltage curve for graphene with defects we have determined that the behavior of the I–V curves is nonlinear. It is also found that the SV and SW defects cause to decrease the current compared to the pristine graphene case. Furthermore, the single vacancy defect reduces the current more than the Stone-Wales defect. Moreover, we observed that by increasing the voltage from zero to 1 V new peaks near Fermi level in the transmission probability curves have been created.

  4. The role of alcohol and drugs in homicides in England and Wales.

    Science.gov (United States)

    Shaw, Jenny; Hunt, Isabelle M; Flynn, Sandra; Amos, Tim; Meehan, Janet; Robinson, Jo; Bickley, Harriet; Parsons, Rebecca; McCann, Kerry; Burns, James; Kapur, Nav; Appleby, Louis

    2006-08-01

    The annual number of homicide convictions in England and Wales is increasing. Previous studies have highlighted the aetiological role of alcohol and drugs in homicide. To examine rates of alcohol and drug misuse and dependence in people convicted of homicide; the role of alcohol and drugs in the offence; the social and clinical characteristics of alcohol- and drug-related homicides; and the social and clinical characteristics of patients with dual diagnosis who commit homicide. A national clinical survey based on a 3-year (1996-9) consecutive sample of people convicted of homicide in England and Wales. Information on rates of alcohol and drug misuse/dependence, the role of alcohol and drugs in the offence and social and clinical characteristics of perpetrators were collected from psychiatric reports prepared for the court in homicide convictions. Detailed clinical information was gathered from questionnaires completed by mental health teams for those in contact with mental health services. Of the 1594 homicide perpetrators, more than one-third (42%) occurred in people with a history of alcohol misuse or dependence and 40% in people with a history of drug misuse or dependence. Alcohol or drug misuse played a contributory role in two-fifths of homicides. Alcohol played a major role in 52 (6%) and a minor role in 364 (39%) homicides. Drugs played a major role in six (1%) and a minor role in 138 (14%) homicides. Forty-two homicides (17%) were committed by patients with severe mental illness and substance misuse. Alcohol- and drug-related homicides were generally associated with male perpetrators who had a history of violence, personality disorders, mental health service contact and with stranger victims. Substance misuse contributes to the majority of homicides in England and Wales. A public health approach to homicide would highlight alcohol and drugs before severe mental illness.

  5. Defining geo-habitats for groundwater ecosystem assessments: an example from England and Wales (UK)

    Science.gov (United States)

    Weitowitz, Damiano C.; Maurice, Louise; Lewis, Melinda; Bloomfield, John P.; Reiss, Julia; Robertson, Anne L.

    2017-12-01

    Groundwater ecosystems comprising micro-organisms and metazoans provide an important contribution to global biodiversity. Their complexity depends on geology, which determines the physical habitat available, and the chemical conditions within it. Despite this, methods of classifying groundwater habitats using geological data are not well established and researchers have called for higher resolution habitat frameworks. A novel habitat typology for England and Wales (UK) is proposed, which distinguishes 11 geological habitats (geo-habitats) on hydrogeological principles and maps their distribution. Hydrogeological and hydrochemical data are used to determine the characteristics of each geo-habitat, and demonstrate their differences. Using these abiotic parameters, a new method to determine abiotic habitat quality is then developed. The geo-habitats had significantly different characteristics, validating the classification system. All geo-habitats were highly heterogeneous, containing both high quality habitat patches that are likely to be suitable for fauna, and areas of low quality that may limit faunal distributions. Karstic and porous habitats generally were higher quality than fractured habitats. Overall, 70% of England and Wales are covered by lower quality fractured habitats, with only 13% covered by higher quality habitats. The main areas of high quality habitats occur in central England as north-south trending belts, possibly facilitating dispersal along this axis. They are separated by low quality geo-habitats that may prevent east-west dispersal of fauna. In south-west England and Wales suitable geo-habitats occur as small isolated patches. Overall, this paper provides a new national-scale typology that is adaptable for studies in other geographic areas.

  6. An analysis of suicide trends in Scotland 1950-2014: comparison with England & Wales.

    Science.gov (United States)

    Dougall, Nadine; Stark, Cameron; Agnew, Tim; Henderson, Rob; Maxwell, Margaret; Lambert, Paul

    2017-12-20

    Scotland has disproportionately high rates of suicide compared with England. An analysis of trends may help reveal whether rates appear driven more by birth cohort, period or age. A 'birth cohort effect' for England & Wales has been previously reported by Gunnell et al. (B J Psych 182:164-70, 2003). This study replicates this analysis for Scotland, makes comparisons between the countries, and provides information on 'vulnerable' cohorts. Suicide and corresponding general population data were obtained from the National Records of Scotland, 1950 to 2014. Age and gender specific mortality rates were estimated. Age, period and cohort patterns were explored graphically by trend analysis. A pattern was found whereby successive male birth cohorts born after 1940 experienced higher suicide rates, in increasingly younger age groups, echoing findings reported for England & Wales. Young men (aged 20-39) were found to have a marked and statistically significant increase in suicide between those in the 1960 and 1965 birth cohorts. The 1965 cohort peaked in suicide rate aged 35-39, and the subsequent 1970 cohort peaked even younger, aged 25-29; it is possible that these 1965 and 1970 cohorts are at greater mass vulnerability to suicide than earlier cohorts. This was reflected in data for England & Wales, but to a lesser extent. Suicide rates associated with male birth cohorts subsequent to 1975 were less severe, and not statistically significantly different from earlier cohorts, suggestive of an amelioration of any possible influential 'cohort' effect. Scottish female suicide rates for all age groups converged and stabilised over time. Women have not been as affected as men, with less variation in patterns by different birth cohorts and with a much less convincing corresponding pattern suggestive of a 'cohort' effect. Trend analysis is useful in identifying 'vulnerable' cohorts, providing opportunities to develop suicide prevention strategies addressing these cohorts as they age.

  7. Capacity withholding in wholesale electricity markets: The experience in England and Wales

    Science.gov (United States)

    Quinn, James Arnold

    This thesis examines the incentives wholesale electricity generators face to withhold generating capacity from centralized electricity spot markets. The first chapter includes a brief history of electricity industry regulation in England and Wales and in the United States, including a description of key institutional features of England and Wales' restructured electricity market. The first chapter also includes a review of the literature on both bid price manipulation and capacity bid manipulation in centralized electricity markets. The second chapter details a theoretical model of wholesale generator behavior in a single price electricity market. A duopoly model is specified under the assumption that demand is non-stochastic. This model assumes that duopoly generators offer to sell electricity at their marginal cost, but can withhold a continuous segment of their capacity from the market. The Nash equilibrium withholding strategy of this model involves each duopoly generator withholding so that it produces the Cournot equilibrium output. A monopoly model along the lines of the duopoly model is specified and simulated under the assumption that demand is stochastic. The optimal strategy depends on the degree of demand uncertainty. When there is a moderate degree of demand uncertainty, the optimal withholding strategy involves production inefficiencies. When there is a high degree of demand uncertainty, the optimal monopoly quantity is greater than the optimal output level when demand is non-stochastic. The third chapter contains an empirical examination of the behavior of generators in the wholesale electricity market in England and Wales in the early 1990's. The wholesale market in England and Wales is analyzed because the industry structure in the early 1990's created a natural experiment, which is described in this chapter, whereby one of the two dominant generators had no incentive to behave non-competitively. This chapter develops a classification methodology

  8. Australian doctors and the visual arts. Part 1. Doctor-artists in New South Wales.

    Science.gov (United States)

    Hamilton, D G

    Since Europeans first settled in Australia their doctors have been interested in the visual arts. Some have been hobby painters and sculptors, a few with great distinction. Some have been gallery supporters and administrators. A few have written art books. Some have been outstanding photographers. Of the larger number of doctors who have collected art, only those are mentioned who have made their collections public or have made important donations to galleries. The subject of Australian doctors and the visual arts will be discussed in six articles in this and following issues of the journal. The first deals with doctor-artists in New South Wales.

  9. Neofusicoccum luteum associated with leaf necrosis and fruit rot of olives in New South Wales, Australia

    Directory of Open Access Journals (Sweden)

    V. Sergeeva

    2009-09-01

    Full Text Available Neofusicoccum luteum is reported for the first time from olives (Olea europaea, causing fruit rot and leaf necrosis. Affected fruits initially became brown with pycnidia developing on the surface, later drying out and becoming mummified. The fungus was shown to be pathogenic on both fruits and leaves. The association of Botryosphaeriaceae with rotting olive fruits in Mediterranean regions and in New South Wales, Australia indicates that these fungi play a significant role in fruit rots of olives and deserve greater attention.

  10. Bayesian conditional-independence modeling of the AIDS epidemic in England and Wales

    Science.gov (United States)

    Gilks, Walter R.; De Angelis, Daniela; Day, Nicholas E.

    We describe the use of conditional-independence modeling, Bayesian inference and Markov chain Monte Carlo, to model and project the HIV-AIDS epidemic in homosexual/bisexual males in England and Wales. Complexity in this analysis arises through selectively missing data, indirectly observed underlying processes, and measurement error. Our emphasis is on presentation and discussion of the concepts, not on the technicalities of this analysis, which can be found elsewhere [D. De Angelis, W.R. Gilks, N.E. Day, Bayesian projection of the the acquired immune deficiency syndrome epidemic (with discussion), Applied Statistics, in press].

  11. Levels of radioactivity in Wales from the accident at Chernobyl, USSR on 26 April 1986

    International Nuclear Information System (INIS)

    1986-07-01

    This document contains a compilation of the results of environmental monitoring for radioactivity and radiation in Wales following the accident at Chernobyl, USSR, on 26 April 1986. The compilation has been prepared by the National Radiological Protection Board at the request of the Welsh Office and includes all information available to the NRPB up to 23 May 1986. Data are presented under the following headings: Background information, concentrations in air, water (rain, surface, tapwater, non-potable), grass, outdoor dose rates, concentrations in cows, goats and ewes' milk, concentrations in leafy vegetables and other foods. (U.K.)

  12. Education activities for environment and sustainability: A Snapshot of eight New South Wales councils

    Directory of Open Access Journals (Sweden)

    Jade Herriman

    2010-07-01

    Full Text Available This paper describes in brief the findings of a research project undertaken by the Institute for Sustainable Futures (ISF at the University of Technology, Sydney, Australia. The research was commissioned by and undertaken on behalf of the New South Wales (NSW Department of Environment, Climate Change and Water (DECCW. The aim of the project was to investigate current practices of environmental and sustainability education and engagement within local government in NSW. The research was commissioned by DECCW as the preliminary phase of a larger project that the department is planning to undertake, commencing in 2010.

  13. Psychiatric morbidity in prisoners with intellectual disabilities: analysis of prison survey data for England and Wales.

    Science.gov (United States)

    Hassiotis, Angela; Gazizova, Dina; Akinlonu, Leah; Bebbington, Paul; Meltzer, Howard; Strydom, Andre

    2011-08-01

    A substantial number of prisoners have intellectual disabilities. We analysed data on a sample drawn from all prisons in England and Wales. Intellectual disability was defined as Quick Test scores equivalent to an IQ of ≤65. We found a significantly higher prevalence of probable psychosis, attempted suicide and cannabis use in prisoners with intellectual disabilities. Presence of intellectual disability was twice as likely to be associated with probable psychosis but the relationship was fully mediated by self-rated health status. It is important to identify this group as early as possible in order to provide timely interventions to cope in adverse environments and manage substance misuse.

  14. Mental health legislation and human rights in England, Wales and the Republic of Ireland.

    Science.gov (United States)

    Kelly, Brendan D

    2011-01-01

    In 2005, the World Health Organization (WHO) published its Resource Book on Mental Health, Human Rights and Legislation (Geneva: WHO) presenting a detailed statement of human rights issues which need to be addressed in national legislation relating to mental health. The purpose of this paper is to determine the extent to which revised mental health legislation in England, Wales (2007) and Ireland (2001) accords with these standards (excluding standards relating solely to children or mentally-ill offenders). Legislation in England and Wales meets 90 (54.2%) of the 166 WHO standards examined, while legislation in Ireland meets 80 standards (48.2%). Areas of high compliance include definitions of mental disorder, relatively robust procedures for involuntary admission and treatment (although provision of information remains suboptimal) and clarity regarding offences and penalties Areas of medium compliance relate to competence, capacity and consent (with a particular deficit in capacity legislation in Ireland), oversight and review (which exclude long-term voluntary patients and require more robust complaints procedures), and rules governing special treatments, seclusion and restraint. Areas of low compliance relate to promoting rights (impacting on other areas within legislation, such as information management), voluntary patients (especially non-protesting, incapacitated patients), protection of vulnerable groups and emergency treatment. The greatest single deficit in both jurisdictions relates to economic and social rights. There are four key areas in need of rectification and clarification in relation to mental health legislation in England, Wales and Ireland; these relate to (1) measures to protect and promote the rights of voluntary patients; (2) issues relating to competence, capacity and consent (especially in Ireland); (3) the role of "common law" in relation to mental health law (especially in England and Wales); and (4) the extent to which each jurisdiction

  15. The Contribution of the New South Wales Primary Schools Sports Association towards Developing Talent in Australian 12-Year-Old Female Swimmers

    Science.gov (United States)

    Light, Richard

    2012-01-01

    This article reports on a case study that inquired into the influence of the New South Wales Primary Schools Sports Association competitive swimming structure on the development of talented 12-year old female swimmers. The study focused on ten 12-year old girls in the New South Wales team that contested the 2009 national swimming championships…

  16. Geophysical interpretation of U, Th, and rare earth element mineralization of the Bokan Mountain peralkaline granite complex, Prince of Wales Island, southeast Alaska

    Science.gov (United States)

    McCafferty, Anne E.; Stoeser, Douglas B.; Van Gosen, Bradley S.

    2014-01-01

    A prospectivity map for rare earth element (REE) mineralization at the Bokan Mountain peralkaline granite complex, Prince of Wales Island, southeastern Alaska, was calculated from high-resolution airborne gamma-ray data. The map displays areas with similar radioelement concentrations as those over the Dotson REE-vein-dike system, which is characterized by moderately high %K, eU, and eTh (%K, percent potassium; eU, equivalent parts per million uranium; and eTh, equivalent parts per million thorium). Gamma-ray concentrations of rocks that share a similar range as those over the Dotson zone are inferred to locate high concentrations of REE-bearing minerals. An approximately 1300-m-long prospective tract corresponds to shallowly exposed locations of the Dotson zone. Prospective areas of REE mineralization also occur in continuous swaths along the outer edge of the pluton, over known but undeveloped REE occurrences, and within discrete regions in the older Paleozoic country rocks. Detailed mineralogical examinations of samples from the Dotson zone provide a means to understand the possible causes of the airborne Th and U anomalies and their relation to REE minerals. Thorium is sited primarily in thorite. Uranium also occurs in thorite and in a complex suite of ±Ti±Nb±Y oxide minerals, which include fergusonite, polycrase, and aeschynite. These oxides, along with Y-silicates, are the chief heavy REE (HREE)-bearing minerals. Hence, the eU anomalies, in particular, may indicate other occurrences of similar HREE-enrichment. Uranium and Th chemistry along the Dotson zone showed elevated U and total REEs east of the Camp Creek fault, which suggested the potential for increased HREEs based on their association with U-oxide minerals. A uranium prospectivity map, based on signatures present over the Ross-Adams mine area, was characterized by extremely high radioelement values. Known uranium deposits were identified in the U-prospectivity map, but the largest tract occurs

  17. Global Derivatives

    DEFF Research Database (Denmark)

    Andersen, Torben Juul

    approaches to dealing in the global business environment." - Sharon Brown-Hruska, Commissioner, Commodity Futures Trading Commission, USA. "This comprehensive survey of modern risk management using derivative securities is a fine demonstration of the practical relevance of modern derivatives theory to risk......" provides comprehensive coverage of different types of derivatives, including exchange traded contracts and over-the-counter instruments as well as real options. There is an equal emphasis on the practical application of derivatives and their actual uses in business transactions and corporate risk...... management situations. Its key features include: derivatives are introduced in a global market perspective; describes major derivative pricing models for practical use, extending these principles to valuation of real options; practical applications of derivative instruments are richly illustrated...

  18. Transition mechanism of Stone-Wales defect in armchair edge (5,5) carbon nanotube

    Science.gov (United States)

    Setiadi, Agung; Suprijadi

    2015-04-01

    We performed first principles calculations of Stone-Wales (SW) defects in armchair edge (5,5) carbon nanotube (CNT) by the density functional theory (DFT). Stone Wales (SW) defect is one kind of topological defect on the CNT. There are two kind of SW defect on the armchair edge (5,5) CNT, such as longitudinal and circumference SW defect. Barrier energy in the formation of SW defects is a good consideration to become one of parameter in controlling SW defects on the CNT. Our calculation results that a longitudinal SW defect is more stable than circumference SW defect. However, the barrier energy of circumference SW defect is lower than another one. We applied Climbing Image Nudge Elastic Band (CI-NEB) method to find minimum energy path (MEP) and barrier energy for SW defect transitions. We also found that in the case of circumference SW defect, armchair edge (5,5) CNT become semiconductor with the band gap of 0.0544 eV.

  19. Economic growth and health progress in England and Wales: 160 years of a changing relation.

    Science.gov (United States)

    Tapia Granados, José A

    2012-03-01

    Using data for England and Wales during the years 1840-2000, a negative relation is found between economic growth--measured by the rate of growth of gross domestic product (GDP)--and health progress--as indexed by the annual increase in life expectancy at birth (LEB). That is, the lower is the rate of growth of the economy, the greater is the annual increase in LEB for both males and females. This effect is much stronger, however, in 1900-1950 than in 1950-2000, and is very weak in the 19th century. It appears basically at lag zero, though some short-lag effects of the same negative sign are found. In the other direction of causality, there are very small effects of the change in LEB on economic growth. These results add to an emerging consensus that in the context of long-term declining trends, mortality oscillates procyclically during the business cycle, declining faster in recessions. Therefore, LEB increases faster during recessions than during expansions. The investigation also shows how the relation between economic growth and health progress changed in England and Wales during the study period. No evidence of cointegration between income--as indexed by GDP or GDP per capita--and health--as indexed by LEB--is found. Copyright © 2012 Elsevier Ltd. All rights reserved.

  20. A survey of non-accidental injury imaging in England, Scotland and Wales

    Energy Technology Data Exchange (ETDEWEB)

    James, S L.J.; Halliday, K; Somers, J; Broderick, N

    2003-09-01

    AIM: To identify the potential national variation in non-accidental injury (NAI) imaging in England, Scotland and Wales. MATERIALS AND METHODS: A postal survey was sent to 323 hospitals with both paediatric and radiology departments. These were identified by a search through the Medical Directory. RESULTS: One hundred and thirteen of 323 postal questionnaires were returned within the study period (35%). Sixteen were excluded from the study because either no NAI imaging was performed at that institution or an incorrect address had been used. The total number of completed questionnaires was 97 (30%). Extensive variation was seen in all aspects of NAI imaging including imaging techniques used, total case numbers, follow-up imaging and those who report the NAI imaging. CONCLUSIONS: There is currently no national protocol that incorporates all aspects of NAI imaging in England, Scotland and Wales. Extensive variation in practice has been shown by this survey. Further standardization of NAI imaging practice is required. The draft BSPR skeletal survey guidelines and routine neurological imaging is recommended.

  1. Deemed consent: assessing the new opt-out approach to organ procurement in Wales.

    Science.gov (United States)

    Albertsen, Andreas

    2018-05-01

    In December 2015, Wales became the first country in the UK to move away from an opt-in system in organ procurement. The new legislation introduces the concept of deemed consent whereby a person who neither opt in nor opt out is deemed to have consented to donation. The data released by the National Health Service (NHS) in July 2017 provide an excellent opportunity to assess this legislation in light of concerns that it would decrease procurement rates for living and deceased donation, as well as sparking an increase in family refusals. None of these concerns have come to pass, with Wales experiencing more registered donors, fewer family refusals and more living donations. However, as the number of actual donors has dropped slightly from a high level, the situation must be monitored closely in the years to come. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  2. Leprosy in England and Wales 1953-2012: surveillance and challenges in low incidence countries.

    Science.gov (United States)

    Fulton, Nicholas; Anderson, Laura F; Watson, John M; Abubakar, Ibrahim

    2016-05-03

    To review all notified cases of leprosy in England and Wales between 1953 and 2012. National surveillance study of all reported cases. England and Wales. Number and characteristics of reported cases. During this period, a total of 1449 leprosy cases were notified. The incidence fell from 356 new cases notified between 1953 and 1962 to 139 new cases between 2003 and 2012. Where data were available, leprosy was more common in men, 15-45 year olds and those from the Indian subcontinent. There was considerable undernotification in 2001-2012. The high level of under-reporting indicates a need for improved surveillance in the UK. Public Health England, in collaboration with the UK Panel of Leprosy opinion, has revised the UK Memorandum on Leprosy in order to provide updated guidance on diagnostic procedures, treatment, case management, contact tracing and notification. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  3. Options for the management of Chernobyl-restricted areas in England and Wales

    International Nuclear Information System (INIS)

    Nisbet, Anne; Woodman, Rona

    2000-01-01

    Areas in England and Wales are still subject to restrictions on the movement, sale and slaughter of sheep because activity concentrations of 137 Cs in sheepmeat may exceed the 1000 Bq kg -1 limit imposed after the Chernobyl nuclear power plant accident. The operation of various monitoring programmes has enabled lamb production to be sustained in restricted areas. Under present circumstances, it is predicted that some restrictions will remain until at least 2003. This paper describes an assessment of the practicability and cost-effectiveness of five alternative management options: utilisation of existing improved land for the purposes of clean feeding; improvement of unimproved upland grazing for the purposes of clean feeding; provision of housing and clean feed; administration of boli containing ammonium ferric hexacyanoferrate; and monitoring at the market place. The practicability of each option, which encompasses technical feasibility, capacity, cost, impact and acceptability, was assessed through a series of case studies carried out on farms in the restricted area of north Wales, and through consultation with a range of organisations with interests in farming and/or the environment. Recommendations are made for the future management of the restricted areas

  4. Lost in translation: reviewing the role of the discharge liaison nurse in Wales.

    Science.gov (United States)

    Chandler, Lynda; Wyatt, Matt; Roberts, Iain

    2010-02-01

    In Wales, the National Leadership and Innovation Agency in Healthcare (NLIAH) Change Agent Team (CAT) has found that its service improvement methodology of Communities of Practice (CoP), where motivated frontline staff in health and social care come together to share issues and develop solutions to mutual problems, is a highly effective and informative tool. Health and social care organizations in Wales are in the process of working to develop processes and solutions to remedy the challenges they have over patients with long lengths of stay. This article shows how by speaking to the frontline staff, whose role it is to help people whose discharge is likely to be complex or problematic, they often have most insight into the solutions required to alleviate the situation. The learning in this article is that there is no one solution to improve the discharge process; however there are a number of small changes and improvements required, which if done consistently can have a significant impact. The findings here have been shared with Welsh government policy leads and health and social care executive teams to inform their planning and actions on how to resolve the challenge of reducing length of stay.

  5. Water Scarcity in England and Wales as a Failure of (metaGovernance

    Directory of Open Access Journals (Sweden)

    Gareth Walker

    2014-06-01

    Full Text Available The water crisis is often said to be a crisis of governance failure rather than of availability per se; yet the sources of this failure are poorly understood. This paper examines contemporary water scarcity in England and Wales as a failure of ecological modernity, in which technical and institutional innovation is promoted as a means of increasing economic efficiency in the allocation and use of water resources. The role of the state in fostering this innovation is explored through exploring a shift from 'government' to 'governance'. The paper employs Jessopʼs theory of meta-governance to examine governance failure. Meta-governance represents the capacity of the state to flank or support the emergence of specific forms of governance through mobilising material or symbolic resources. Three sources of governance failure are explored: (1 the nature of capitalist exchange and its resulting production of nature, (2 the political dimensions implicit in meta-governance, and (3 the nature of governance as a task of self-organisation. The model is then applied to the rise of water scarcity in England and Wales from the 1970s to the present day. The utility of the model in analysing governance failure is discussed.

  6. Schisms in the church: National Health Service systems and institutional divergence in England and Wales.

    Science.gov (United States)

    Hughes, David; Vincent-Jones, Peter

    2008-12-01

    Since devolution, the four countries of the United Kingdom have pursued strikingly different National Health Service (NHS) reforms. While England created a supply-side market more radical than the previous internal market system, Wales moved to a softer version of the purchaser/provider split emphasizing localism. This article deploys institutional theory to analyze the forces shaping change, and describes the hybrid forms of economic organization emerging, including the economic regulation model implemented in England. The schism that has resulted in separate NHS subsystems warrants a different analysis from the more familiar phenomenon of infield divergence. We argue that schism was triggered by political-regulatory influences rather than economic or other social institutional forces, and predict that other decentralized public health care systems may follow a similar path. While political-regulatory, normative, and cognitive institutional influences push in the same direction in Wales, the misalignment of political-regulatory and normative elements in England looks set to result in a period of organizational turbulence.

  7. Financial Derivatives

    DEFF Research Database (Denmark)

    Wigan, Duncan

    2013-01-01

    Contemporary derivatives mark the development of capital and constitute a novel form of ownership. By reconfiguring the temporal, spatial and legal character of ownership derivatives present a substantive challenge to the tax collecting state. While fiscal systems are nationally bounded...... and inherently static, capital itself is unprecedentedly mobile, fluid and fungible. As such derivatives raise the specter of ‘financial weapons of mass destruction’....

  8. Financial Derivatives

    OpenAIRE

    Janečková, Alena

    2011-01-01

    1 Abstract/ Financial derivatives The purpose of this thesis is to provide an introduction to financial derivatives which has been, from the legal perspective, described in a not satisfactory manner as quite little literature that can be found about this topic. The main objectives of this thesis are to define the term "financial derivatives" and its particular types and to analyse legal nature of these financial instruments. The last objective is to try to draft future law regulation of finan...

  9. Large-Area, High-Resolution Tree Cover Mapping with Multi-Temporal SPOT5 Imagery, New South Wales, Australia

    Directory of Open Access Journals (Sweden)

    Adrian Fisher

    2016-06-01

    Full Text Available Tree cover maps are used for many purposes, such as vegetation mapping, habitat connectivity and fragmentation studies. Small remnant patches of native vegetation are recognised as ecologically important, yet they are underestimated in remote sensing products derived from Landsat. High spatial resolution sensors are capable of mapping small patches of trees, but their use in large-area mapping has been limited. In this study, multi-temporal Satellite pour l’Observation de la Terre 5 (SPOT5 High Resolution Geometrical data was pan-sharpened to 5 m resolution and used to map tree cover for the Australian state of New South Wales (NSW, an area of over 800,000 km2. Complete coverages of SPOT5 panchromatic and multispectral data over NSW were acquired during four consecutive summers (2008–2011 for a total of 1256 images. After pre-processing, the imagery was used to model foliage projective cover (FPC, a measure of tree canopy density commonly used in Australia. The multi-temporal imagery, FPC models and 26,579 training pixels were used in a binomial logistic regression model to estimate the probability of each pixel containing trees. The probability images were classified into a binary map of tree cover using local thresholds, and then visually edited to reduce errors. The final tree map was then attributed with the mean FPC value from the multi-temporal imagery. Validation of the binary map based on visually assessed high resolution reference imagery revealed an overall accuracy of 88% (±0.51% standard error, while comparison against airborne lidar derived data also resulted in an overall accuracy of 88%. A preliminary assessment of the FPC map by comparing against 76 field measurements showed a very good agreement (r2 = 0.90 with a root mean square error of 8.57%, although this may not be representative due to the opportunistic sampling design. The map represents a regionally consistent and locally relevant record of tree cover for NSW, and

  10. Impact of geographic area level on measuring socioeconomic disparities in cancer survival in New South Wales, Australia: A period analysis.

    Science.gov (United States)

    Stanbury, Julia F; Baade, Peter D; Yu, Yan; Yu, Xue Qin

    2016-08-01

    Area-based socioeconomic measures are widely used in health research. In theory, the larger the area used the more individual misclassification is introduced, thus biasing the association between such area level measures and health outcomes. In this study, we examined the socioeconomic disparities in cancer survival using two geographic area-based measures to see if the size of the area matters. We used population-based cancer registry data for patients diagnosed with one of 10 major cancers in New South Wales (NSW), Australia during 2004-2008. Patients were assigned index measures of socioeconomic status (SES) based on two area-level units, census Collection District (CD) and Local Government Area (LGA) of their address at diagnosis. Five-year relative survival was estimated using the period approach for patients alive during 2004-2008, for each socioeconomic quintile at each area-level for each cancer. Poisson-regression modelling was used to adjust for socioeconomic quintile, sex, age-group at diagnosis and disease stage at diagnosis. The relative excess risk of death (RER) by socioeconomic quintile derived from this modelling was compared between area-units. We found extensive disagreement in SES classification between CD and LGA levels across all socioeconomic quintiles, particularly for more disadvantaged groups. In general, more disadvantaged patients had significantly lower survival than the least disadvantaged group for both CD and LGA classifications. The socioeconomic survival disparities detected by CD classification were larger than those detected by LGA. Adjusted RER estimates by SES were similar for most cancers when measured at both area levels. We found that classifying patient SES by the widely used Australian geographic unit LGA results in underestimation of survival disparities for several cancers compared to when SES is classified at the geographically smaller CD level. Despite this, our RER of death estimates derived from these survival

  11. Arthurian Toponymics: Folk Tradition or Antiquarian Invention? Review of the book: Lloyd, S. (2017. The Arthurian Place Names of Wales. Cardiff: University of Wales Press.

    Directory of Open Access Journals (Sweden)

    Will Parker

    2018-03-01

    Full Text Available The article reviews Scott Lloyd’s survey of Arthurian place names in Wales, and the background to this material in the literature and scholarship of the modern and medieval periods. The reviewer presents an overview of Lloyd’s scope and methodology, situating it within the context of current trends in the wider field of Celtic studies. Lloyd’s survey shows that Arthurian toponymics is a modern as much as a medieval problem. The mutual influence between the map-makers on one hand, and the scholars and story-tellers on the other, is best regarded as a dynamic work-in-progress, rather than a passive snapshot of timeless folk tradition. Lloyd’s most significant discovery is the relative fluidity of Arthurian toponymics, with many of the place names in question first appearing on the cartographic or literary record no earlier than the 19th century. The case of the common Welsh place name Arthur’s Quoits or Coetan Arthur is considered, and Lloyd’s implication of a 17th century origin for this form is critically discussed. Attention is drawn to the alternating currents of scepticism and reconstructionism that have defined Arthurian scholarship and literature from the Tudor period onwards. The author then offers some concluding thoughts on Arthur’s “ontological ambiguity,” and the powerful stimulus this seems to have exerted on topographical and historiographical speculation, both modern and medieval.

  12. Oil-based technology and economy prospects for the future. A short introduction to basic issues and a review of oil depletion projections derived from different theories and methods

    International Nuclear Information System (INIS)

    2003-12-01

    Recognising the world economy's technological dependence on oil and, hence, the serious consequences of a decline in oil production for which the world community is technologically unprepared, The Danish Board of Technology and The Society of Danish Engineers wish to draw attention to the issue and to the different analyses of oil resources and future oil production potentials published by various researchers and institutions, In pursuance of this objective, the two institutions have jointly commissioned this review and organised the conference Oil Demand, Production and Cost - Prospects for the Future. The aim of the review is to outline the characteristics of the cheap-oil economy and provide the participants in the conference and other interested parties with an overview of different scenarios for the future development in demand and supply, presented by various experienced researchers and institutions who base their analyses on different methodologies. The evidence thus provided should constitute a structured framework for the discussion at the conference. (BA)

  13. What Makes the Digital "Special"? The Research Program in Digital Collections at the National Library of Wales

    Science.gov (United States)

    Cusworth, Andrew; Hughes, Lorna M.; James, Rhian; Roberts, Owain; Roderick, Gareth Lloyd

    2015-01-01

    This article introduces some of the digital projects currently in development at the National Library of Wales as part of its Research Program in Digital Collections. These projects include the digital representation of the Library's Kyffin Willams art collection, musical collections, and probate collection, and of materials collected by the…

  14. Australian doctors and the visual arts. Part 2. Doctors as collectors, donors, gallery supporters and writers in New South Wales.

    Science.gov (United States)

    Hamilton, D G

    1986-04-28

    The contribution of doctors to the visual arts if being discussed in a series of six articles. The first article dealt with doctor-artists in new South Wales. In this, the second, doctors are discussed as collectors, donors, gallery supporters and writers in this State.

  15. Teaching Children the Geography of England and Wales: An Analysis of Selected Georgian and Victorian Textbooks and Educational Pastimes

    Science.gov (United States)

    Dove, Jane

    2017-01-01

    Children in Georgian and Victorian times were expected to be familiar with the geography of England and Wales. This study analyses some of the resources then available which taught children this information. John Aikin's "England Delineated" is evaluated as a geographical text and then compared with less formal games and puzzles, then on…

  16. Population size, breeding habitat and nest site distribution of little penguins (Eudyptula minor) on Montague Island, New South Wales

    NARCIS (Netherlands)

    Brunsting, A.M.H.; Weerheim, M.S.; Klomp, N.I.; Komdeur, J.

    2003-01-01

    The distribution of little penguin nest sites on Montague Island, New South Wales, was examined in relation to vegetation type, distance to landing sites and local footpaths. Nest site density was negatively correlated with distance to landing sites and positively correlated with distance to

  17. Incredible Years Parent Training Support for Nursery Staff Working within a Disadvantaged Flying Start Area in Wales: A Feasibility Study

    Science.gov (United States)

    Bywater, Tracey Jane; Hutchings, Judith Mary; Gridley, Nicole; Jones, Karen

    2011-01-01

    Parenting programmes are effective interventions for preventing and treating conduct problems in young children. Up to 20% of children in disadvantaged areas have conduct disorder. Recent government initiatives such as targeting early years services to designated disadvantaged Flying Start areas in Wales have resulted in increased nursery-care…

  18. "Ars Poetica," Romanticism and English Education: Poetic Inheritances in the Senior Secondary English Curriculum in New South Wales, Australia

    Science.gov (United States)

    Carter, Don

    2013-01-01

    Poetry, as a textual form for critical study and composition, continues to occupy a significant place in Australian senior secondary English syllabus documents and classrooms (cf. Carter, 2012). Indeed, within the senior secondary English syllabus in New South Wales (NSW), poetry remains one of the core mandatory types of texts for study by the…

  19. First GB records of the invasive Asian shore crab, Hemigrapsus sanguineus from Glamorgan, Wales and Kent, England.

    OpenAIRE

    Seeley, B; Sewell, J; Clark, PF

    2015-01-01

    The present contribution reports on the capture of two adult male specimens of the Asian/Japanese shore crab, Hemigrapsus sanguineus (de Haan, 1835) from Glamorgan, south Wales and Kent, southern England. These represent the first records of this species from mainland Great Britain.

  20. Expectations and Levels of Understanding When Using Mobile Phones among 9-11-Year Olds in Wales, UK

    Science.gov (United States)

    Turley, Joanne; Baker, Sally-Ann; Lewis, Christopher Alan

    2014-01-01

    There is growing interest in examining the use of mobile technology among children. The present study extended this literature among a sample of 9-11-year olds in Wales, UK in three ways. First, to examine the level of mobile phone ownership; second, to consider how mobile phones are used, investigate timescales and expectations when communicating…

  1. An Analysis of the Stakeholder Model of Public Boards and the Case of School Governing Bodies in England and Wales

    Science.gov (United States)

    Connolly, Michael; Farrell, Catherine; James, Christopher

    2017-01-01

    This article analyses the stakeholder model of boards that is widely used in public and third sector institutions in England and Wales. The central tenet of this model is that such institutions should be strategically led by individuals who are representative of and from the groups that have an interest in them. The article focuses in particular…

  2. An Operational In Situ Soil Moisture & Soil Temperature Monitoring Network for West Wales, UK: The WSMN Network.

    Science.gov (United States)

    Petropoulos, George P; McCalmont, Jon P

    2017-06-23

    This paper describes a soil moisture dataset that has been collecting ground measurements of soil moisture, soil temperature and related parameters for west Wales, United Kingdom. Already acquired in situ data have been archived to the autonomous Wales Soil Moisture Network (WSMN) since its foundation in July 2011. The sites from which measurements are being collected represent a range of conditions typical of the Welsh environment, with climate ranging from oceanic to temperate and a range of the most typical land use/cover types found in Wales. At present, WSMN consists of a total of nine monitoring sites across the area with a concentration of sites in three sub-areas around the region of Aberystwyth located in Mid-Wales. The dataset of composed of 0-5 (or 0-10) cm soil moisture, soil temperature, precipitation, and other ancillary data. WSMN data are provided openly to the public via the International Soil Moisture Network (ISMN) platform. At present, WSMN is also rapidly expanding thanks to funding obtained recently which allows more monitoring sites to be added to the network to the wider community interested in using its data.

  3. Diet and food availability: implications for foraging and dispersal of Prince of Wales northern flying squirrels across managed landscapes

    Science.gov (United States)

    Elizabeth A. Flaherty; Merav Ben-David; Winston P. Smith

    2010-01-01

    Where dispersal is energetically expensive, feeding and food availability can influence dispersal success. The endemic Prince of Wales northern flying squirrel (Glaucomys sabrinus griseifrons) inhabits a landscape mosaic of old-growth, second-growth, and clearcut stands, with the latter two representing energetically expensive habitats. We...

  4. Experiences of Autism Spectrum Disorder and Policing in England and Wales: Surveying Police and the Autism Community

    Science.gov (United States)

    Crane, Laura; Maras, Katie L.; Hawken, Tamsyn; Mulcahy, Sue; Memon, Amina

    2016-01-01

    An online survey gathered the experiences and views of 394 police officers (from England and Wales) regarding autism spectrum disorder (ASD). Just 42% of officers were satisfied with how they had worked with individuals with ASD and reasons for this varied. Although officers acknowledged the need for adjustments, organisational/time constraints…

  5. Passive acoustic monitoring of bottlenose dolphin and harbour porpoise, in Cardigan Bay, Wales, with implications for habitat use and partitioning

    DEFF Research Database (Denmark)

    Simon, Malene Juul; Nuuttila, Hanna; Reyes-Zamudio, Mercedes M

    2010-01-01

    Knowledge about harbour porpoise and bottlenose dolphin occurrence in Cardigan Bay Special Area of Conservation (SAC), Wales, is limited to daylight hours during summer, when conditions are suitable for traditional visual surveys. T-PODs are autonomous instruments programmed to log time-cues of s...

  6. From Vision to Reality: Views of Primary School Principals on Inclusive Education in New South Wales, Australia

    Science.gov (United States)

    Graham, Linda J.; Spandagou, Ilektra

    2011-01-01

    This paper discusses the findings of a research study that used semi-structured interviews to explore the views of primary school principals on inclusive education in New South Wales, Australia. Content analysis of the transcript data indicates that principals' attitudes towards inclusive education and their success in engineering inclusive…

  7. Geographic distribution of lung and stomach cancers in England and Wales over 50 years: changing and unchanging patterns.

    Science.gov (United States)

    Swerdlow, A J; dos Santos Silva, I

    1991-05-01

    The distribution of cancers of the lung and stomach in the counties of England and Wales in 1968-81 was mapped, and compared to the distribution in the country in 1921-30 described by Stocks. The high risk of stomach cancer in North Wales noted by Stocks was found still to exist in each sex, although its disparity from the rest of the country has diminished. In general the geographic distribution of stomach cancer in both periods has paralleled that of post-neonatal mortality, at the same time and earlier, as an index of general poverty, but postneonatal mortality in North Wales has not been exceptionally high. In 1921-30 the highest risk of lung cancer was in and around London. In the modern data this was still true for older women, but for men and women under 45 years of age, and to a lesser extent for older men, the pattern has changed greatly; the epidemic has moved north, and highest risk is now in Northumberland and Durham. This spread appears to have occurred earlier for men than for women, and for urban than for rural areas, occurring latest of all for women in rural areas. Regional disparity has also increased, especially in males: risks in the northern regions are now over twice those in much of Wales and the South.

  8. Distance Learning Masters Students in the Department of Information Studies, University of Wales, Aberystwyth: Past, Present and Future

    Science.gov (United States)

    Preston, Hugh

    2005-01-01

    This paper examines the postgraduate student body studying by distance learning within the Department of Information Studies at the University of Wales, Aberystwyth. The demands of both students and employers have been the chief influences on the evolution of the specialist postgraduate programmes and also the later generalist and further…

  9. Changes in classification of suicide in England and Wales : Time trends and associations with coroners' professional backgrounds

    NARCIS (Netherlands)

    Neeleman, J; Wessely, S

    Background. The legal definition of suicide in England and Wales (E&W) gives rise to a high proportion of open verdicts and an underestimated suicide rate. We examined whether the ratio between open and suicide verdicts in E&W has changed between 1974 and 1991 and whether it varies according to

  10. Uranium project. Geochemistry prospection

    International Nuclear Information System (INIS)

    Lambert, J.

    1983-01-01

    Geochemistry studies the distribution of the chemicals elements in the terrestrial crust and its ways to migrate. The terminology used in this report is the following one: 1) Principles of the prospection geochemistry 2) Stages of the prospection geochemistry 3)utility of the prospection geochemistry 4) geochemistry of uranium 5) procedures used within the framework of uranium project 6) Average available 7) Selection of the zones of prospection geochemistry 8) Stages of the prospection, Sample preparation and analisis 9) Presentation of the results

  11. Incidence and mortality of primary liver cancer in England and Wales: changing patterns and ethnic variations.

    Science.gov (United States)

    Ladep, Nimzing G; Khan, Shahid A; Crossey, Mary Me; Thillainayagam, Andrew V; Taylor-Robinson, Simon D; Toledano, Mireille B

    2014-02-14

    To explore recent trends, modes of diagnosis, ethnic distribution and the mortality to incidence ratio of primary liver cancer by subtypes in England and Wales. We obtained incidence (1979-2008) and mortality (1968-2008) data for primary liver cancer for England and Wales and calculated age-standardised incidence and mortality rates. Trends in age-standardised mortality (ASMR) and incidence (ASIR) rates and basis of diagnosis of primary liver cancer and subcategories: hepatocellular carcinoma, intrahepatic bile duct and unspecified liver tumours, were analysed over the study period. Changes in guidelines for the diagnosis of primary liver cancer (PLC) may impact changing trends in the rates that may be obtained. We thus explored changes in the mode of diagnosis as reported to cancer registries. Furthermore, we examined the distribution of these tumours by ethnicity. Most of the statistical manipulations of these data was carried out in Microsoft excel® (Seattle, Washington, United Sttaes). Additional epidemiological statistics were done in Epi Info software (Atlanta, GA, United Sttaes). To define patterns of change over time, we evaluated trends in ASMR and ASIR of PLC and intrahepatic bile duct carcinoma (IHBD) using a least squares regression line fitted to the natural logarithm of the mortality and incidence rates. We estimated the patterns of survival over subsequent 5 and 10 years using complement of mortality to incidence ratio (1-MIR). Age-standardised mortality rate of primary liver cancer increased in both sexes: from 2.56 and 1.29/100000 in 1968 to 5.10 and 2.63/100000 in 2008 for men and women respectively. The use of histology for diagnostic confirmation of primary liver cancer increased from 35.7% of registered cases in 1993 to plateau at about 50% during 2005 to 2008. Reliance on cytology as a basis of diagnosis has maintained a downward trend throughout the study period. Although approximately 30% of the PLC registrations had information on

  12. Opportunity costs and local health service spending decisions: a qualitative study from Wales.

    Science.gov (United States)

    Karlsberg Schaffer, Sarah; Sussex, Jon; Hughes, Dyfrig; Devlin, Nancy

    2016-03-25

    All health care systems face the need to find the resources to meet new demands such as a new, cost-increasing health technology. In England and Wales, when a health technology is recommended by the National Institute for Health and Care Excellence (NICE), the National Health Service (NHS) is mandated to provide the funding to accommodate it within three months of publication of the recommendation. Identifying what, in practice, is foregone when new cost-increasing technologies are introduced is important for understanding the effects of health technology assessment (HTA) decisions on the NHS or any other health care system. Our objective was to investigate how in practice local NHS commissioners in Wales accommodated financial "shocks" arising from technology appraisals (TAs) issued by NICE and from other cost pressures. Semi-structured interviews were conducted with Finance Directors and Medical Directors from all seven Local Health Boards (LHBs) in NHS Wales. These interviews covered prioritisation processes, as well as methods of financing NICE TAs and other financial shocks at each LHB. We then undertook a systematic identification of themes and topics from the information recorded. The study relates to the period October 2010 to March 2013. The financial impact of NICE TAs is generally anticipated and planned for in advance and the majority of LHBs have contingency funds available to cope with these and other financial shocks within-period. Efficiency savings (defined as reductions in costs with no assumed reductions in quality) were a source of funds for cost pressures of all kinds. Service displacements were not linkable to particular NICE TAs and there appears to be a general lack of explicit prioritisation activities. The Welsh Government has, on occasion, explicitly or implicitly acted as the funder of last resort. Services may be displaced as part of a response to the cumulative impact of all types of cost pressures, including cost-increasing health

  13. Developing the mental health awareness of prison staff in England and Wales.

    Science.gov (United States)

    Walsh, Elizabeth; Freshwater, Dawn

    2009-10-01

    In 2010, the prison population in England and Wales could reach a high of 91,500, according to a recent population projection. HM Prison Service (U.K.) reports that in 2004 to 2005, there were 33,144 prison officers employed to care for the prisoners in the prison system. This article focuses on the mental health of this prisoner population and the training needs of staff caring for them. It reports the experience of a national project, funded by the Department of Health, in which the project team developed and piloted mental health awareness training for prison officers on the residential units and for staff who work with prisoners and lack a mental health background. Key findings from the posttraining evaluation are highlighted. Participant feedback demonstrates the value placed on this type of training by those working in the prison setting.

  14. Strategic pricing of grid access under partial price-caps. Electricity distribution in England and Wales

    International Nuclear Information System (INIS)

    Riechmann, C.

    2000-01-01

    It is perceived in public debate that monopolistic network operators (who are vertically integrated into competitively organised activities) would raise excessive access charges to derail competition by newcomers. Economic reasoning, however, suggests that the level of access charges is, at least in a simple setting, irrelevant for the intensity of entry by newcomers. In a setting where access charges are price-cap regulated, theoretical considerations and empirical findings for the case of electricity distribution in England and Wales even suggest that inefficiently high access charges correspond with intense market entry. Efficiency concerns remain, nonetheless. If regulated by a practicable partial price-cap, the network operator may enforce monopolistic access charges in certain market segments. Access charges in other segments may be lowered strategically and may even be cross-subsidised. 36 refs

  15. Sugary drink consumption and dental caries in New South Wales teenagers.

    Science.gov (United States)

    Skinner, J; Byun, R; Blinkhorn, A; Johnson, G

    2015-06-01

    The consumption of water, milk and various sugary drinks and their relationship with the caries experience of a random sample of teenagers aged 14 to 15 years living in New South Wales, Australia was investigated. Data were obtained from both clinical and questionnaire components of the NSW Teen Dental Survey, 2010. The analyses allowed for various demographic and behavioural risk factors using caries experience (DMFT >0) and mean DMFT as the key outcome variables. Males were more likely than females to consume large volumes of sugary drinks. Consuming two or more glasses of sugary drinks per day led to significantly increased caries experience amongst this sample of 14 and 15 year olds. Factors found to be associated with elevated sugary drink consumption included family income, gender, and mother's education level. There is a strong correlation between increased caries experience of NSW teenagers and high levels of consumption of sugary drinks. © 2015 Australian Dental Association.

  16. Management of whiplash injuries presenting to accident and emergency departments in Wales

    Science.gov (United States)

    Logan, A; Holt, M

    2003-01-01

    Methods: Questionnaires were sent to 76 full time accident and emergency staff across Wales inquiring into their management of soft tissue sprains/strains of the neck and soft collar use. Results: The overall response rate was 74% (SHO 70%, registrar 65%, consultant 100%). Half of consultants and more than half of the middle grade and junior staff reported soft collar use in this condition. As required wear was most commonly recommended and instructions for use ranged from one day only to until the patient was pain free. Conclusion: The study recommends treatment protocols for whiplash injuries prescribing regular analgesia, early home exercises with the help of an advice sheet, and physiotherapy if symptoms persist. PMID:12835348

  17. Electricity profits: how much is enough. [Accounting practices in England and Wales

    Energy Technology Data Exchange (ETDEWEB)

    Dean, P

    1979-08-17

    The profits announced by the electric-supply industry in England and Wales vary according to which accounting system is used. Up to 1976-1977 the industry prepared its accounts on the assumption of historic cost. The system worked well when replacement costs were close to acquisition costs. Inflation has changed this and, following the oil crisis, money lost its value and it has become more expensive to replace assets. The industry decided that providing for depreciation on the basis of replacement cost was more meaningful than the historic-cost basis. Too little was known about replacement costs, and in 1977-1978 a supplementary charge equivalent to 40% of conventional depreciation was introduced. An interim arrangement, the Hyde guidelines, was announced in 1977 and adopted by the industry. How the industry used the guidelines and other accounting methods are discussed. (MCW)

  18. Land regeneration: soil development through forestation on former opencast coal-lands in upland Wales

    Energy Technology Data Exchange (ETDEWEB)

    Haigh, M.J. [Oxford Brookes University, Oxford (United Kingdom)

    2001-07-01

    The degradation of lands that have been 'reclaimed' after surface coal mining is an international concern. Research near the UNESCO World Heritage site for industrial land at Blaenavon, Wales, seeks more effective ways of creating self-sustaining soils on coal-lands, where the auto-compaction of minespoils causes land degradation. Remedies are sought through the use of close-planted trees as bio-accumulators. Preliminary findings suggest that: 1. forestation quickly mitigates soil compaction, 2. soil fertilisation with NPK improves the survival rate of Alnus glutinosa but may not enhance average growth, 3. soil remineralisation with basic igneous rock flour may be more effective than conventional NPK application alone for enhancing both survival rates and growth and that 4. soil disturbance causes long term depletion of the soil microbial ecosystem. 16 refs., 1 fig., 4 tabs.

  19. Comparing electricity distribution network revenues and costs in New South Wales, Great Britain and Victoria

    International Nuclear Information System (INIS)

    Mountain, Bruce; Littlechild, Stephen

    2010-01-01

    A decade ago, electricity distribution network revenues per customer in New South Wales (NSW) were twice those in Great Britain (GB). Recent price controls imply that by 2014 they will be nearly four times as high. This paper examines possible reasons for this. The main reason does not seem to be geography, operating environment or industry structure. GB and Victoria have managed to accommodate increasing demand at broadly constant or even declining costs and revenues while delivering higher quality of service, while NSW has not. The regulatory framework and the practice of the regulatory body within that framework seem relevant. Australian regulators have not used benchmarking techniques as the GB regulator has. Perhaps the most important explanatory factor is private ownership in GB and Victoria compared to state ownership in NSW. This could also impact on the nature and effectiveness of regulation. (author)

  20. Geographical trends in infant mortality: England and Wales, 1970-2006.

    Science.gov (United States)

    Norman, Paul; Gregory, Ian; Dorling, Danny; Baker, Allan

    2008-01-01

    At national level in England and Wales, infant mortality rates fell rapidly from the early 1970s and into the 1980s. Subnational areas have also experienced a reduction in levels of infant mortality. While rates continued to fall to 2006, the rate of reduction has slowed. Although the Government Office Regions Yorkshire and The Humber, the North West and the West Midlands and the Office for National Statistics local authority types Cities and Services and London Cosmopolitan have experienced relatively large absolute reductions in infant mortality, their rates remained high compared with the national average. Within all regions and local authority types, a strong relationship was found between ward level deprivation and infant mortality rates. Nevertheless, levels of infant mortality declined over time even in the most deprived areas with a narrowing of absolute differences in rates between areas. Areas in which the level of deprivation eased have experienced greater than average reductions in levels of infant mortality.

  1. Enduring love? Attitudes to family and inheritance law in England and Wales.

    Science.gov (United States)

    Douglas, Gillian; Woodward, Hilary; Humphrey, Alun; Mills, Lisa; Morrell, Gareth

    2011-01-01

    This paper reports on the findings from a large-scale study of public attitudes to inheritance law, particularly the rules on intestacy. It argues that far from the assumption that the family' is in terminal decline, people in England and Wales still view their most important relationships, at least for the purposes of inheritance law, as centred on a narrow, nuclear family model. However, there is also widespread acceptance of re-partnering and cohabitation, producing generally high levels of support for including cohabitants in the intestacy rules and for ensuring that children from former relationships are protected. We argue that these views are underpinned by a continuing sense of responsibility to the members of one's nuclear family, arising from notions of sharing and commitment, dependency and support, and a sense of lineage.

  2. Carbon nanotube as NEMS sensor - effect of chirality and stone-wales defect intend

    International Nuclear Information System (INIS)

    Gayathri, V; Geetha, R

    2006-01-01

    Having nanosize and unique electrical properties, carbon nanotubes (CNTs) attract lot of interest among scientific community all over the world. One of the recent observations is its role as nanosensors. Obviously the nanosize and high strength of CNT are most preferred parameter for technical and electromechanical field in the industrial point of view. The defects in CNT structure have a vital role in determining their electrical and mechanical properties. Our earlier study indicates an effective role played by the topological defects like pentagon and octagon on the electromechanical properties of these nanostructures. Here our aim is to look in to the effect of Stone-wales defect and chirality on this property of nanotubes deformed under applied pressure. Among the three kinds of tubes considered for this study, we observed that armchair (5, 5) tube is more suitable for sensor applications

  3. Use of videoconferencing in Wales to reduce carbon dioxide emissions, travel costs and time.

    Science.gov (United States)

    Lewis, Delyth; Tranter, Glynis; Axford, Alan T

    2009-01-01

    In September 2005 a telemedicine service was started to assist multidisciplinary teams in Wales to improve cancer services. In October 2006 and October 2007 users of videoconferencing equipment at one site completed questionnaires. During October 2006 a total of 18,000 km of car travel were avoided, equivalent to 1696 kg of CO(2) emission. During October 2007 a total of 20,800 km of car travel were avoided, equivalent to 2590 kg of CO(2) emission. We estimate that 48 trees would take a year to absorb that quantity of CO(2). The results of the surveys show that exploiting telemedicine makes better use of staff time, reduces the time spent travelling and assists in reducing climate change by limiting the emissions of CO(2).

  4. Assessment and treatment of sex offenders: the Prince of Wales Programme.

    Science.gov (United States)

    McConaghy, N

    1990-06-01

    The treatment programme for sex offenders at the Prince of Wales Hospital, Sydney, is described. Penile circumference assessment is not used as there is no evidence it provides a valid measure of individuals' paedophile or rapist tendencies. Sex offenders' self-reports remain the major source of information in their assessment. The development of the two major techniques used--imaginal desensitization and short-term medroxyprogesterone--is outlined. About 80% of subjects can be expected to show a good response to one or other of these therapies. Of those who do not, most respond to the alternative or aversive therapy. Adolescent offenders appear to require more intensive treatment. Results appear comparable with those of more intensive programmes in use overseas.

  5. Paracetamol poisoning and hepatotoxicity in Chinese--the Prince of Wales Hospital (Hong Kong) experience.

    Science.gov (United States)

    Chan, T Y; Chan, A Y; Critchley, J A

    1993-08-01

    From 1989 to 1991, 104 Chinese patients were admitted to the Prince of Wales Hospital with paracetamol poisoning. Only 11 subjects had a plasma paracetamol concentration above the published treatment line. Intravenous N-acetylcysteine (NAC) was completely effective when given within 8 hours (3 patients), while late treatment with NAC at 16 and 26 hours after overdose (2 patients) was ineffective in preventing liver damage as evidenced by elevations in plasma alanine transaminase concentrations. Of the 6 patients receiving NAC between 10 to 15 hours, two had liver damage. Two other subjects who presented late or in whom a plasma paracetamol concentration was not measured also developed liver damage. Fortunately, none of these 6 subjects developed hepatic encephalopathy. We recommend that a standard protocol be readily available for junior hospital staff to use when treating patients with paracetamol overdosage.

  6. Gender Comparison of Young People Charged With Murder in England and Wales.

    Science.gov (United States)

    Gerard, F Jeane; Browne, Kevin D; Whitfield, Kate C

    2017-03-01

    This study investigated gender differences regarding young people charged with murder in England and Wales. A sample of 318 cases was collected from the Home Office's Homicide Index and analysed. Of these cases, 93% of the offenders were male and 7% female. The analyses explored gender differences in terms of the offender's race, offender's age, victim's age, victim's gender, weapon used, offender-victim relationship, and circumstances of the offence. The study found that a female offender was significantly more likely to murder a family member than a male offender, and a male offender was significantly more likely to murder a stranger than a female offender. In addition, a female offender was significantly more likely to murder a victim below the age of 5 than a male offender. Implications for interventions with young people who are charged with murder are discussed.

  7. Masculinity and domesticity in 1930s South Wales: did unemployment change the domestic division of labour?

    Science.gov (United States)

    Penlington, Neil

    2010-01-01

    This article examines masculinity in an area suffering from sustained high unemployment and unremitting hardship during the 1930s: the South Wales coalfield had some of the highest rates of male unemployment and the lowest participation rates of married women in paid employment in Britain. Particular attention is drawn to power relations between husband and wife by looking at the domestic division of labour and whether male unemployment affected the split in domestic responsibilities. Personal testimonies are used to assess how men filled their time whilst unemployed and the meanings they attached to their activities and relationships. It will be shown that some unemployed men engaged more in the home and that many men were able to maintain existing power relations with their wives by finding or creating alternative manual work and maintaining an elastic relationship with the home by continuing to spend the majority of their time in the company of other men.

  8. Structural and electronic properties of zigzag InP nanoribbons with Stone–Wales type defects

    International Nuclear Information System (INIS)

    Longo, R C; Carrete, J; Varela, L M; Gallego, L J

    2016-01-01

    By means of density-functional-theoretic calculations, we investigate the structural and electronic properties of a hexagonal InP sheet and of hydrogen-passivated zigzag InP nanoribbons (ZInPNRs) with Stone–Wales (SW)-type defects. Our results show that the influence of this kind of defect is not limited to the defected region but it leads to the formation of ripples that extend across the systems, in keeping with the results obtained recently for graphene and silicene sheets. The presence of SW defects in ZInPNRs causes an appreciable broadening of the band gap and transforms the indirect-bandgap perfect ZInPNR into a direct-bandgap semiconductor. An external transverse electric field, regardless of its direction, reduces the gap in both the perfect and defective ZInPNRs. (paper)

  9. EIA scoping in England and Wales: Practitioner approaches, perspectives and constraints

    International Nuclear Information System (INIS)

    Wood, Graham; Glasson, John; Becker, Julia

    2006-01-01

    Scoping plays a critical role in shaping the nature and extent of the environmental information subsequently contained in an Environmental Impact Statement (EIS), yet it has been identified as an area of weakness in practice () and remains a poorly understood and under-researched component of EIA. This paper provides a detailed empirical investigation and assessment of recent scoping activity in England and Wales, in the context of evolving European Union (EU) regulations. Conceptual and contextual issues associated with scoping are outlined prior to the presentation of key findings, including: approaches to scoping; the assessment of significance; characteristics and influence of consultation; and perceived constraints to scoping. The paper concludes with an overview of findings, possible explanatory factors, and recommendations for future practice

  10. Imposed Stories: Prisoner Self-narratives in the Criminal Justice System in New South Wales, Australia

    Directory of Open Access Journals (Sweden)

    Maggie Hall

    2016-03-01

    Full Text Available This article examines the ways in which offenders are required to provide very particular accounts of themselves and to self-narrate in confined ways. Drawing on ethnographic fieldwork and interviews conducted in the New South Wales justice system, it explores how the stories that offenders are made to accept and tell about themselves often bear little relationship to their own reflections. It analyses how, despite the expectations of judges and prison authorities, these self-narratives are not products of an offender’s soul-searching concerning his past actions and experience; rather they are products of an official legal narrative being imposed on an offender whose capacity to own and enact such a narrative is already seriously compromised.

  11. Radiometric ages of some igneous rocks from the southern and southwestern coalfields of New South Wales

    International Nuclear Information System (INIS)

    Carr, P.F.; Facer, R.A.

    1980-01-01

    Samples from six igneous rock units of the Southern and Southwestern Coalfields (Sydney Basin) of New South Wales have been dated using the K-Ar radiometric technique. The following ages were determined: a dolerite from Towradgi, 243 +- 10 MY; a dolerite from a diamond-drill hole at Sutton Forest, 202 +- 8 MY; the Bong Bong Basalt, 190 +- 8 MY; the Good Dog Lamprophyre, 101 +- 4 MY; a teschenite from South Bulli coal mine 74.0 +- 3.6 MY; and a dolerite from Robertson, 63.8 +- 3.2 MY. Combination of these new ages wth previously-published ages indicates that igneous activity in the Southern and Southwestern Coalfields occurred during four discrete periods of time - Middle-to-Late Permian; Late Triassic to Early Jurassic; mid-Cretaceous (only the Good Dog Lamprophyre has yielded such an age); and latest Cretaceous to Late Oligocene

  12. Unilateral and collusive market power in the electricity pool of England and Wales

    International Nuclear Information System (INIS)

    Bunn, D.W.; Martoccia, M.

    2005-01-01

    This paper uses a detailed market microsimulation of agent bidding behaviour to provide insights into the evolution of generator market power in the electricity pool of England and Wales. We identify an evolution, as market concentration declined, from unilateral market power dominance in the early years (1990-1996) to tacit collusive coordination towards the end (1996-2001), whereupon the pool was replaced by voluntary bilateral trading. The microsimulation analysis does not provide closed form solutions for market equilibrium nor a multi-agent co-evolutionary set of scenarios, but provides a diagnostic aid in determining when market concentration may decline to the point at which price leadership gives way to tacit collusion as means of exercising market power. (author)

  13. Diet and coronary heart disease in England and Wales during and after the second world war.

    Science.gov (United States)

    Barker, D J; Osmond, C

    1986-03-01

    During the second world war there were large changes in consumption of fats, fibre, and sugar in Britain. These changes matched recent recommendations made by the Committee on Medical Aspects of Food Policy (COMA) with the object of reducing the incidence of coronary heart disease (CHD). It is widely believed that CHD mortality fell during the war. This paper re-examines CHD mortality among middle-aged people in England and Wales from 1931 to 1967. After allowance for changes in the rules for coding cause of death, and for the sharp increase in all-causes mortality in 1940, there is little to suggest that time trends in CHD were much influenced by the war. Because of confounding variables, this does not argue against the COMA report. However, it gives no support to the view that compliance with the recommendations on fat, fibre, and sugar will lead, by itself, to an appreciable fall in CHD mortality in middle-aged people.

  14. Eye and sheath folds in turbidite convolute lamination: Aberystwyth Grits Group, Wales

    Science.gov (United States)

    McClelland, H. L. O.; Woodcock, N. H.; Gladstone, C.

    2011-07-01

    Eye and sheath folds are described from the turbidites of the Aberystwyth Group, in the Silurian of west Wales. They have been studied at outcrop and on high resolution optical scans of cut surfaces. The folds are not tectonic in origin. They occur as part of the convolute-laminated interval of each sand-mud turbidite bed. The thickness of this interval is most commonly between 20 and 100 mm. Lamination patterns confirm previous interpretations that convolute lamination nucleated on ripples and grew during continued sedimentation of the bed. The folds amplified vertically and were sheared horizontally by continuing turbidity flow, but only to average values of about γ = 1. The strongly curvilinear fold hinges are due not to high shear strains, but to nucleation on sinuous or linguoid ripples. The Aberystwyth Group structures provide a warning that not all eye folds in sedimentary or metasedimentary rocks should be interpreted as sections through high shear strain sheath folds.

  15. Exercise intensities of gardening tasks within older adult allotment gardeners in Wales.

    Science.gov (United States)

    Hawkins, Jemma L; Smith, Alexander; Backx, Karianne; Clayton, Deborah A

    2015-04-01

    Previous research has suggested that gardening activity could be an effective form of regular exercise for improving physical and psychological health in later life. However, there is a lack of data regarding the exercise intensities of various gardening tasks across different types of gardening and different populations. The purpose of this study was to examine the exercise intensity of gardening activity for older adult allotment gardeners in Wales, United Kingdom following a similar procedure used in previous studies conducted in the United States and South Korea by Park and colleagues (2008a; 2011). Oxygen consumption (VO2) and energy expenditure for six gardening tasks were measured via indirect calorimetery using the portable Oxycon mobile device. From these measures, estimated metabolic equivalent units (METs) were calculated. Consistent with Park et al. (2008a; 2011) the six gardening tasks were classified as low to moderate-high intensity physical activities based on their metabolic values (1.9-5.7 METs).

  16. Development of nutrition standards and therapeutic diet specifications for public hospitals in New South Wales.

    Science.gov (United States)

    Williams, Peter; Hazlewood, Tanya; Pang, Glen

    2014-09-01

    In New South Wales (NSW), a new suite of nutrition standards for menus and specifications for therapeutic diets to be used in hospitals has been developed. These standards were required to facilitate centralised menu planning and food production, with the move to management of most hospital food services by HealthShare NSW, a state-wide business unit of NSW Health. The standards also aim to improve communication between health professionals, particularly with the increasing use of computerised meal-ordering systems. Nutrition standards have been developed for adult, paediatric and mental health inpatients, and specifications for 147 different adult and paediatric therapeutic diets. There is still significant variation in the nutrition standards for nutrition and therapeutic diets in hospitals across the Australian states, and a move to a more nationally harmonised approach would be welcome. Further research is required to examine the impact of these standards on operating efficiency and patient care outcomes.

  17. Clinical diagnosis and chemical confirmation of ciguatera fish poisoning in New South Wales, Australia.

    Science.gov (United States)

    Farrell, Hazel; Zammit, Anthony; Manning, Jennifer; Shadbolt, Craig; Szabo, Lisa; Harwood, D Tim; McNabb, Paul; Turahui, John A; van den Berg, Debra J

    2016-03-31

    Ciguatera fish poisoning is common in tropical and sub-tropical areas and larger fish (> 10 kg) are more susceptible to toxin accumulation with age. Although the coastal climate of northern New South Wales is considered sub-tropical, prior to 2014 there has only been 1 documented outbreak of ciguatera fish poisoning from fish caught in the region. During February and March 2014, 2 outbreaks of ciguatera fish poisoning involved 4 and 9 individuals, respectively, both following consumption of Spanish mackerel from northern New South Wales coastal waters (Evans Head and Scotts Head). Affected individuals suffered a combination of gastrointestinal and neurological symptoms requiring hospital treatment. At least 1 individual was symptomatic up to 7 months later. Liquid chromatography-tandem mass spectrometry detected the compound Pacific ciguatoxin-1B at levels up to 1.0 µg kg(-1) in fish tissue from both outbreaks. During April 2015, another outbreak of ciguatera fish poisoning was reported in 4 individuals. The fish implicated in the outbreak was caught further south than the 2014 outbreaks (South West Rocks). Fish tissue was unavailable for analysis; however, symptoms were consistent with ciguatera fish poisoning. To our knowledge, these cases are the southernmost confirmed sources of ciguatera fish poisoning in Australia. Educational outreach to the fishing community, in particular recreational fishers was undertaken after the Evans Head outbreak. This highlighted the outbreak, species of fish involved and the range of symptoms associated with ciguatera fish poisoning. Further assessment of the potential for ciguatoxins to occur in previously unaffected locations need to be considered in terms of food safety.

  18. Autism characteristics and behavioural disturbances in ~ 500 children with Down's syndrome in England and Wales.

    Science.gov (United States)

    Warner, Georgina; Moss, Joanna; Smith, Patrick; Howlin, Patricia

    2014-08-01

    Recent research shows that a significant minority of children with Down's syndrome (DS) also meet diagnostic criteria for an autism spectrum disorder (ASD). The present study investigated what proportion of children aged 6-15 years with a confirmed diagnosis of DS in England and Wales display autistic-type behaviours, and explored the characteristics of this group of children. The Social Communication Questionnaire (SCQ) was used to screen for autism characteristics and the Strengths and Difficulties Questionnaire (SDQ) to explore behavioural difficulties. The proportion of children who met the cut-off score for ASD on the SCQ (total score ≥ 15) was 37.7% (95% CI: 33.4-42.0%); for autism (total score ≥ 22) the proportion was 16.5% (95% CI: 13.2-19.8%). Children who met the cut-off for ASD were significantly more likely to be reported as having emotional symptoms, conduct problems and hyperactivity on the SDQ than children who scored well below cut-off (total score autism characteristics on the SCQ was atypical compared with individuals with idiopathic ASD. The pervasiveness of ASD in children with DS in England and Wales is substantially higher than in the general population. These children also experience significantly greater behavioural problems than children with DS only. Early detection of autism characteristics is important for appropriate intervention. However, the unusual profile of autism characteristics in this group may affect the recognition of the disorder and hinder the implementation of appropriate interventions. © 2014 International Society for Autism Research, Wiley Periodicals, Inc.

  19. The maldistribution of general practitioners in England and Wales: 1974–2003

    Science.gov (United States)

    Hann, Mark; Gravelle, Hugh

    2004-01-01

    Background: The geographical distribution of general practitioners (GPs) is a persistent policy concern within the National Health Service. Maldistribution across family health service authorities in England and Wales fell between 1974 and the mid-1980s but then remained, at best, constant until the mid-1990s. Aim: To estimate levels of maldistribution over the period 1994–2003 and to examine the long-term trend in maldistribution from 1974–2003. Design: Annual snapshots from the GP census. Setting: One hundred 2001 ‘frozen’ health authorities in England and Wales for 1994–2003 and 98 family health service authorities for 1974–1995. Method: Ratios of GPs to raw and need-adjusted populations were calculated for each health authority for each year using four methods of need adjustment: age-related capitation payments, national age- and sex-specific consultation rates, national age- and sex-specific limiting long-term illness rates, and health authority-specific mortality. Three summary measures of maldistribution across health authorities in the GP to population ratio — the decile ratio, the Gini coefficient, and the Atkinson index — were calculated for each year. Results: Maldistribution of GPs as measured by the Gini coefficient and Atkinson index increased from the mid-1980s to 2003, but the decile ratio showed little change over the entire 1974–2003 period. Unrestricted GP principals and equivalents were more equitably distributed than other types of GP. Conclusion: The 20% increase in the number of unrestricted GPs between 1985 and 2003 did not lead to a more equal distribution. PMID:15588532

  20. TRENDS IN MORTALITY FROM OCCUPATIONAL HAZARDS AMONG MEN IN ENGLAND AND WALES DURING 1979-2010

    Science.gov (United States)

    Harris, E Clare; Palmer, Keith T; Cox, Vanessa; Darnton, Andrew; Osman, John; Coggon, David

    2016-01-01

    Objectives To monitor the impact of health and safety provisions and inform future preventive strategies, we investigated trends in mortality from established occupational hazards in England and Wales. Methods We analysed data from death certificates on underlying cause of death and last full-time occupation for 3,688,916 deaths among men aged 20-74 years in England and Wales during 1979-2010 (excluding 1981 when records were incomplete). Proportional mortality ratios (PMRs), standardised for age and social class, were calculated for occupations at risk of specified hazards. Observed and expected numbers of deaths for each hazard were summed across occupations, and the differences summarised as average annual excesses. Results Excess mortality declined substantially for most hazards. For example, the annual excess of deaths from chronic bronchitis and emphysema fell from 170.7 during 1979-90 to 36.0 in 2001-10, and that for deaths from injury and poisoning from 237.0 to 87.5. In many cases the improvements were associated with falling PMRs (suggesting safer working practices), but they also reflected reductions in the numbers of men employed in more hazardous jobs, and declining mortality from some diseases across the whole population. Notable exceptions to the general improvement were diseases caused by asbestos, especially in some construction trades and sinonasal cancer in woodworkers. Conclusions The highest priority for future prevention of work-related fatalities is the minority of occupational disorders for which excess mortality remains static or is increasing, in particular asbestos-related disease among certain occupations in the construction industry and sinonasal cancer in woodworkers. PMID:26976946

  1. Leading causes of certification for blindness and partial sight in England & Wales

    Directory of Open Access Journals (Sweden)

    Wormald Richard

    2006-03-01

    Full Text Available Abstract Background Prevention of visual impairment is an international priority agreed at the World Health Assembly of 2002- yet many countries lack contemporary data about incidence and causes from which priorities for prevention, treatment and management can be identified. Methods Registration as blind or partially-sighted in England and Wales is voluntary and is initiated by certification by a consultant ophthalmologist. From all certificates completed during the year April 1999 to March 2000, the main cause of visual loss was ascertained where possible and here we present information on the leading causes observed and comment on changes in the three leading causes since the last analysis conducted for 1990–1991 data. Results 13788 people were certified as blind, 19107 were certified as partially sighted. The majority of certifications were in the older age groups. The most commonly recorded main cause of certifications for both blindness (57.2 % and partial sight (56 % was degeneration of the macula and posterior pole which largely comprises age-related macular degeneration. Glaucoma and diabetic retinopathy were the next most commonly recorded main causes. Overall, the age specific incidence of all three leading causes has increased since 1990–1991 – with changes in diabetic retinopathy being the most marked – particularly in the over 65's where figures have more than doubled. Conclusion The numbers of individuals per 100,000 population being certified blind or partially sighted due to the three leading causes – AMD, diabetic retinopathy and glaucoma have increased since 1990. This may to some extent be explained by improved ascertainment. The process of registration for severe visual impairment in England and Wales is currently undergoing review. Efforts must be made to ensure that routine collection of data on causes of severe visual impairment is continued, particularly in this age of improved technology, to allow such trends

  2. Derivative chameleons

    International Nuclear Information System (INIS)

    Noller, Johannes

    2012-01-01

    We consider generalized chameleon models where the conformal coupling between matter and gravitational geometries is not only a function of the chameleon field φ, but also of its derivatives via higher order co-ordinate invariants (such as ∂ μ φ∂ μ φ,□φ,...). Specifically we consider the first such non-trivial conformal factor A(φ,∂ μ φ∂ μ φ). The associated phenomenology is investigated and we show that such theories have a new generic mass-altering mechanism, potentially assisting the generation of a sufficiently large chameleon mass in dense environments. The most general effective potential is derived for such derivative chameleon setups and explicit examples are given. Interestingly this points us to the existence of a purely derivative chameleon protected by a shift symmetry for φ → φ+c. We also discuss potential ghost-like instabilities associated with mass-lifting mechanisms and find another, mass-lowering and instability-free, branch of solutions. This suggests that, barring fine-tuning, stable derivative models are in fact typically anti-chameleons that suppress the field's mass in dense environments. Furthermore we investigate modifications to the thin-shell regime and prove a no-go theorem for chameleon effects in non-conformal geometries of the disformal type

  3. Derivative chameleons

    Energy Technology Data Exchange (ETDEWEB)

    Noller, Johannes, E-mail: johannes.noller08@imperial.ac.uk [Theoretical Physics, Blackett Laboratory, Imperial College London, Prince Consort Road, London, SW7 2BZ (United Kingdom)

    2012-07-01

    We consider generalized chameleon models where the conformal coupling between matter and gravitational geometries is not only a function of the chameleon field φ, but also of its derivatives via higher order co-ordinate invariants (such as ∂{sub μ}φ∂{sup μ}φ,□φ,...). Specifically we consider the first such non-trivial conformal factor A(φ,∂{sub μ}φ∂{sup μ}φ). The associated phenomenology is investigated and we show that such theories have a new generic mass-altering mechanism, potentially assisting the generation of a sufficiently large chameleon mass in dense environments. The most general effective potential is derived for such derivative chameleon setups and explicit examples are given. Interestingly this points us to the existence of a purely derivative chameleon protected by a shift symmetry for φ → φ+c. We also discuss potential ghost-like instabilities associated with mass-lifting mechanisms and find another, mass-lowering and instability-free, branch of solutions. This suggests that, barring fine-tuning, stable derivative models are in fact typically anti-chameleons that suppress the field's mass in dense environments. Furthermore we investigate modifications to the thin-shell regime and prove a no-go theorem for chameleon effects in non-conformal geometries of the disformal type.

  4. Co-operation and conflict under hard and soft contracting regimes: case studies from England and Wales.

    Science.gov (United States)

    Hughes, David; Allen, Pauline; Doheny, Shane; Petsoulas, Christina; Vincent-Jones, Peter

    2013-01-01

    This paper examines NHS secondary care contracting in England and Wales in a period which saw increasing policy divergence between the two systems. At face value, England was making greater use of market levers and utilising harder-edged service contracts incorporating financial penalties and incentives, while Wales was retreating from the 1990 s internal market and emphasising cooperation and flexibility in the contracting process. But there were also cross-border spill-overs involving common contracting technologies and management cultures that meant that differences in on-the-ground contracting practices might be smaller than headline policy differences suggested. The nature of real-world contracting behaviour was investigated by undertaking two qualitative case studies in England and two in Wales, each based on a local purchaser/provider network. The case studies involved ethnographic observations and interviews with staff in primary care trusts (PCTs) or local health boards (LHBs), NHS or Foundation trusts, and the overseeing Strategic Health Authority or NHS Wales regional office, as well as scrutiny of relevant documents. Wider policy differences between the two NHS systems were reflected in differing contracting frameworks, involving regional commissioning in Wales and commissioning by either a PCT, or co-operating pair of PCTs in our English case studies, and also in different oversight arrangements by higher tiers of the service. However, long-term relationships and trust between purchasers and providers had an important role in both systems when the financial viability of organisations was at risk. In England, the study found examples where both PCTs and trusts relaxed contractual requirements to assist partners faced with deficits. In Wales, news of plans to end the purchaser/provider split meant a return to less precisely-specified block contracts and a renewed concern to build cooperation between LHB and trust staff. The interdependency of local

  5. Geochemical prospecting in Guiana

    International Nuclear Information System (INIS)

    Coulomb, R.

    1957-01-01

    During the last few years geochemical prospecting techniques have become common usage in the field of mineral deposit prospecting. The real scope of these methods lies in their use in the prospecting of large areas. The most promising use of the geochemistry and hydro-geochemistry of uranium is in heavily forested tropical territories, with few outcrops, where radiometry is strongly handicapped. (author) [fr

  6. Engaging Communities in their Heritage: Collaboration between Higher Education and the Voluntary Sector in Wales and Ireland

    Directory of Open Access Journals (Sweden)

    Alex Bell

    2014-10-01

    Full Text Available The paper focuses on an Interreg funded pilot project entitled ‘Heritage and Culture for Learning, Empowerment and Sustainable Tourism’.  The project was a collaborative development between a Higher Education Institution in Wales and a Voluntary Sector Organisation in Ireland and adopted an innovative approach to engaging communities in their heritage.  The central aim of the project was to develop and promote joint opportunities for the creation of sustainable tourism products which build on the natural assets (people and landscape, built assets, culture and heritage of the Wales Ireland cross border region.  In practice this was achieved through an innovative approach combining research, lifelong learning, higher level skills development, networking, marketing and business development through active engagement of local communities. The pilot project ended in July 2013, and the focus of this presentation is an evaluation of the project outcomes and experiences.

  7. General outbreaks of vero cytotoxin producing Escherichia coli O157 in England and Wales from 1992 to 1994.

    LENUS (Irish Health Repository)

    Wall, P G

    1996-02-02

    We have reviewed all general outbreaks of infection due to Vero cytotoxin producing Escherichia coli (VTEC) O157 reported in England and Wales from 1992 to 1994. One hundred and seventy-three people were affected in 18 outbreaks, compared with 76 people in seven outbreaks in the preceding three years (1989 to 1991). Outbreaks occurred throughout England and Wales. Thirty-eight per cent of cases were admitted to hospital, 21% developed haemolytic uraemic syndrome, and 3% died. VTEC O157 infection causes particular concern because of its serious complications--haemorrhagic colitis and haemolytic uraemic syndrome, its capacity to spread from person to person as well as by food and water, and its reservoir in dairy and beef cattle.

  8. Health and social care regulation in Wales: an integrated system of political, corporate and professional governance for improving public health.

    Science.gov (United States)

    Jewell, Tony; Wilkinson, Jane

    2008-11-01

    Wales is developing a unique integrated system of governance to improve public health, which is diverging from some recent developments in the rest of the UK but shares many common features. There is a focus on strengthening collaborative working and co-ordination between bodies inspecting, regulating and auditing health and social care. Systems are being developed that are proportionate to the level of risk, eliminate unnecessary burdens of external review and support the improvement of services for patients, service users and carers. This is consistent with the Assembly Government's aim to improve the way that public services are delivered in Wales, including strengthening input from the public in the planning, delivery and reporting of regulation and inspection work. The test in the future will be how far we can demonstrate quantitatively and qualitatively the added value from our uniquely Welsh approach, built as it is on devolution and the aspirations for small-country governance.

  9. Designing a national soil erosion monitoring network for England and Wales

    Science.gov (United States)

    Lark, Murray; Rawlins, Barry; Anderson, Karen; Evans, Martin; Farrow, Luke; Glendell, Miriam; James, Mike; Rickson, Jane; Quine, Timothy; Quinton, John; Brazier, Richard

    2014-05-01

    Although soil erosion is recognised as a significant threat to sustainable land use and may be a priority for action in any forthcoming EU Soil Framework Directive, those responsible for setting national policy with respect to erosion are constrained by a lack of robust, representative, data at large spatial scales. This reflects the process-orientated nature of much soil erosion research. Recognising this limitation, The UK Department for Environment, Food and Rural Affairs (Defra) established a project to pilot a cost-effective framework for monitoring of soil erosion in England and Wales (E&W). The pilot will compare different soil erosion monitoring methods at a site scale and provide statistical information for the final design of the full national monitoring network that will: provide unbiased estimates of the spatial mean of soil erosion rate across E&W (tonnes ha-1 yr-1) for each of three land-use classes - arable and horticultural grassland upland and semi-natural habitats quantify the uncertainty of these estimates with confidence intervals. Probability (design-based) sampling provides most efficient unbiased estimates of spatial means. In this study, a 16 hectare area (a square of 400 x 400 m) positioned at the centre of a 1-km grid cell, selected at random from mapped land use across E&W, provided the sampling support for measurement of erosion rates, with at least 94% of the support area corresponding to the target land use classes. Very small or zero erosion rates likely to be encountered at many sites reduce the sampling efficiency and make it difficult to compare different methods of soil erosion monitoring. Therefore, to increase the proportion of samples with larger erosion rates without biasing our estimates, we increased the inclusion probability density in areas where the erosion rate is likely to be large by using stratified random sampling. First, each sampling domain (land use class in E&W) was divided into strata; e.g. two sub

  10. Understanding the driving forces behind the losses of soil carbon across England and Wales

    Science.gov (United States)

    Bellamy, Patricia

    2010-05-01

    More than twice as much carbon is held in soils as in vegetation or the atmosphere, and changes in soil carbon content can have a large effect on the global carbon budget. The possibility that climate change is being reinforced by increased carbon dioxide emissions from soils owing to rising temperature is the subject of a continuing debate. But evidence for the suggested feedback mechanism has to date come solely from small-scale laboratory and field experiments and modelling studies. Here we use data from the National Soil Inventory of England and Wales obtained between 1978 and 2003 to show that carbon was lost from soils across England and Wales over the survey period at a mean rate of 0.6% yr-1 (relative to the existing soil carbon content). We find that the relative rate of carbon loss increased with soil carbon content and was more than 2% yr-1 in soils with carbon contents greater than 100 g kg-1. The relationship between rate of carbon loss and carbon content is irrespective of land use, suggesting a link to climate change. Our findings indicate that losses of soil carbon in England and Wales—and by inference in other temperate regions—are likely to have been offsetting absorption of carbon by terrestrial sinks. To investigate the possible driving forces of the measured losses of soil carbon we applied a simple model of soil carbon turnover to evaluate alternative explanations for the observed trends. We find that neither changes in decomposition resulting from the effects of climate change on soil temperature and moisture, nor changes in carbon input from vegetation, could account on their own for the overall trends. Of other explanations, results indicate that past changes in land use and management were probably dominant. The climate change signal, such as it is, is masked by these other changes. A more sophisticated model of carbon change (DAYCENT) has now been applied across the whole range of soils in England and Wales. This model has been

  11. Prospects of particle physics

    International Nuclear Information System (INIS)

    Meyer-Berkhout, U.

    1986-01-01

    Remarkable progress has been achieved in the last two decades in the field of particle physics. From the insight gained by the many experimental data, physicists derive a framework picture of matter on the sub-nuclear level, consisting of fundamental components which interact with each other in a defined and quantitatively detectable manner. The data now available allowed a quantum field theory of strong interactions to be set up for the first time, and a unified theory of electromagnetic and weak interaction. Particle physicists today take particular interest in the problem of whether the strong interaction might fit into an extended unified theory. Such a grand unified theory would have a far-reaching impact on the conceptual models both of the cosmic and sub-nuclear dimensions, and possibly lead to observable effects in domains of energy and mass which will be opened up for experiments by the new accelerator generation underway. Current activities throughout the world for constructing or projecting the new high-energy particle accelerators are outlined in the article, together with the prospects expected by particle physicists, and a look back on the history and achievements of this field of science. (orig.) [de

  12. The association of cancer survival with four socioeconomic indicators: a longitudinal study of the older population of England and Wales 1981–2000

    Directory of Open Access Journals (Sweden)

    Young Harriet

    2007-01-01

    Full Text Available Abstract Background Many studies have found socioeconomic differentials in cancer survival. Previous studies have generally demonstrated poorer cancer survival with decreasing socioeconomic status but mostly used only ecological measures of status and analytical methods estimating simple survival. This study investigate socio-economic differentials in cancer survival using four indicators of socioeconomic status; three individual and one ecological. It uses a relative survival method which gives a measure of excess mortality due to cancer. Methods This study uses prospective record linkage data from The Office for National Statistics Longitudinal Study for England and Wales. The participants are Longitudinal Study members, recorded at census in 1971 and 1981 and with a primary malignant cancer diagnosed at age 45 or above, between 1981 and 1997, with follow-up until end 2000. The outcome measure is relative survival/excess mortality, compared with age and sex adjusted survival of the general population. Relative survival and Poisson regression analyses are presented, giving models of relative excess mortality, adjusted for covariates. Results Different socioeconomic indicators detect survival differentials of varying magnitude and definition. For all cancers combined, the four indicators show similar effects. For individual cancers there are differences between indicators. Where there is an association, all indicators show poorer survival with lower socioeconomic status. Conclusion Cancer survival differs markedly by socio-economic status. The commonly used ecological measure, the Carstairs Index, is adequate at demonstrating socioeconomic differentials in survival for combined cancers and some individual cancers. A combination of car access and housing tenure is more sensitive than the ecological Carstairs measure at detecting socioeconomic effects on survival – confirming Carstairs effects where they occur but additionally identifying

  13. The Diagnosis of Urinary Tract infection in Young children (DUTY): a diagnostic prospective observational study to derive and validate a clinical algorithm for the diagnosis of urinary tract infection in children presenting to primary care with an acute illness.

    Science.gov (United States)

    Hay, Alastair D; Birnie, Kate; Busby, John; Delaney, Brendan; Downing, Harriet; Dudley, Jan; Durbaba, Stevo; Fletcher, Margaret; Harman, Kim; Hollingworth, William; Hood, Kerenza; Howe, Robin; Lawton, Michael; Lisles, Catherine; Little, Paul; MacGowan, Alasdair; O'Brien, Kathryn; Pickles, Timothy; Rumsby, Kate; Sterne, Jonathan Ac; Thomas-Jones, Emma; van der Voort, Judith; Waldron, Cherry-Ann; Whiting, Penny; Wootton, Mandy; Butler, Christopher C

    2016-07-01

    It is not clear which young children presenting acutely unwell to primary care should be investigated for urinary tract infection (UTI) and whether or not dipstick testing should be used to inform antibiotic treatment. To develop algorithms to accurately identify pre-school children in whom urine should be obtained; assess whether or not dipstick urinalysis provides additional diagnostic information; and model algorithm cost-effectiveness. Multicentre, prospective diagnostic cohort study. Children UTI likelihood ('clinical diagnosis') and urine sampling and treatment intentions ('clinical judgement') were recorded. All index tests were measured blind to the reference standard, defined as a pure or predominant uropathogen cultured at ≥ 10(5) colony-forming units (CFU)/ml in a single research laboratory. Urine was collected by clean catch (preferred) or nappy pad. Index tests were sequentially evaluated in two groups, stratified by urine collection method: parent-reported symptoms with clinician-reported signs, and urine dipstick results. Diagnostic accuracy was quantified using area under receiver operating characteristic curve (AUROC) with 95% confidence interval (CI) and bootstrap-validated AUROC, and compared with the 'clinician diagnosis' AUROC. Decision-analytic models were used to identify optimal urine sampling strategy compared with 'clinical judgement'. A total of 7163 children were recruited, of whom 50% were female and 49% were children provided clean-catch samples, 94% of whom were ≥ 2 years old, with 2.2% meeting the UTI definition. Among these, 'clinical diagnosis' correctly identified 46.6% of positive cultures, with 94.7% specificity and an AUROC of 0.77 (95% CI 0.71 to 0.83). Four symptoms, three signs and three dipstick results were independently associated with UTI with an AUROC (95% CI; bootstrap-validated AUROC) of 0.89 (0.85 to 0.95; validated 0.88) for symptoms and signs, increasing to 0.93 (0.90 to 0.97; validated 0.90) with dipstick

  14. Socio-spatial factors associated with ethnic inequalities in districts of England and Wales, 2001–11

    OpenAIRE

    Lymperopoulou, Kitty; Finney, Nissa

    2016-01-01

    This paper explores the changing geography of ethnic inequality in England and Wales drawing on data from the 2001 and 2011 censuses. Specifically, we use the 2011 Office for National Statistics (ONS) area classification to examine how ethnic inequalities within local areas with different demographic and socio-economic characteristics have changed over time. Local ethnic inequalities are examined through a set of indicators which capture differences in housing, health, employment and educatio...

  15. Invasive fish species in the largest lakes of Scotland, Northern Ireland, Wales and England: the collective U.K. experience

    OpenAIRE

    Winfield, I.J.; Fletcher, J.M.; James, J.B.

    2011-01-01

    An invasive species is defined as an alien (or introduced or non-native) species whose establishment and spread threaten ecosystems, habitats or species with harm. Such threats to UK lake fish communities have long been appreciated and this review assembles case histories, including new data, from the largest lakes of Scotland, Northern Ireland, Wales and England to examine the hypothesis that at least some of these introductions have become invasive. Loch Lomond in Scotland has experienced s...

  16. Protocol for implementing the concept of citizen scientists for HealthWise Wales: a national population study

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    Julia Townson

    2017-04-01

    The concept of HealthWise Champion is agreeable to members of the public but appropriate training and support will need to be provided. Materials will be developed in conjunction with the advisory group members to ensure that HealthWise Wales Champions are able to clearly and confidently disseminate the more difficult elements of the study to others e.g data linkage. An evaluation will be available by July.

  17. Personality disorder and offending behaviour: findings from the national survey of male prisoners in England and Wales

    OpenAIRE

    Roberts, Amanda D.L.; Coid, Jeremy W.

    2009-01-01

    Previous studies have related mental disorder and antisocial personality disorder to criminal behaviour, but little is known about the associations with other personality disorders. The aim of this study was to examine independent associations between offending behaviour over the lifetime and personality disorder in a representative sample of male offenders. A two-stage survey was carried out among prisoners in all prisons in England and Wales. DSM-IV personality disorder was measured using S...

  18. An outbreak of Salmonella dublin infection in England and Wales associated with a soft unpasteurized cows' milk cheese.

    OpenAIRE

    Maguire, H.; Cowden, J.; Jacob, M.; Rowe, B.; Roberts, D.; Bruce, J.; Mitchell, E.

    1992-01-01

    An outbreak of Salmonella dublin infection occurred in England and Wales in October to December 1989. Forty-two people were affected, mainly adults, and most lived in south-east England. Microbiological and epidemiological investigations implicated an imported Irish soft unpasteurized cows' milk cheese as the vehicle of infection. A case-control study showed a statistically significant association between infection and consumption of the suspect cheese (p = 0.001). Salmonella dublin was subse...

  19. Making the economic case for prevention – a view from Wales

    Science.gov (United States)

    2012-01-01

    Background It is widely acknowledged that adverse lifestyle behaviours in the population now will place an unsustainable burden on health service resources in the future. It has been estimated that the combined cost to the NHS in Wales of overweight and obesity, alcohol and tobacco is in excess of £540 million. In the current climate of financial austerity, there can be a tendency for the case for prevention efforts to be judged on the basis of their scope for cost savings. This paper was prompted by discussion in Wales about the evidence for the cost savings from prevention and early intervention and a resulting concern that these programmes were thus being evaluated in policy terms using an incorrect metric. Following a review of the literature, this paper contributes to the discussion of the potential role that economics can play in informing decisions in this area. Discussion This paper argues that whilst studies of the economic burden of diseases provide information about the magnitude of the problem faced, they should not be used as a means of priority setting. Similarly, studies discussing the likelihood of savings as a result of prevention programmes may be distorting the arguments for public health. Prevention spend needs to be considered purposefully, resulting in a strategic commitment to spending. The role of economics in this process is to provide evidence demonstrating that information and support can be provided cost effectively to individuals to change their lifestyles thus avoiding lifestyle related morbidity and mortality. There is growing evidence that prevention programmes represent value for money using the currently accepted techniques and decision making metrics such as those advocated by NICE. Summary The issue here is not one of arguing that the economic evaluation of prevention and early intervention should be treated differently, although in some instances that may be appropriate, rather it is about making the case for these

  20. Making the economic case for prevention – a view from Wales

    Directory of Open Access Journals (Sweden)

    Hale Janine

    2012-06-01

    Full Text Available Abstract Background It is widely acknowledged that adverse lifestyle behaviours in the population now will place an unsustainable burden on health service resources in the future. It has been estimated that the combined cost to the NHS in Wales of overweight and obesity, alcohol and tobacco is in excess of £540 million. In the current climate of financial austerity, there can be a tendency for the case for prevention efforts to be judged on the basis of their scope for cost savings. This paper was prompted by discussion in Wales about the evidence for the cost savings from prevention and early intervention and a resulting concern that these programmes were thus being evaluated in policy terms using an incorrect metric. Following a review of the literature, this paper contributes to the discussion of the potential role that economics can play in informing decisions in this area. Discussion This paper argues that whilst studies of the economic burden of diseases provide information about the magnitude of the problem faced, they should not be used as a means of priority setting. Similarly, studies discussing the likelihood of savings as a result of prevention programmes may be distorting the arguments for public health. Prevention spend needs to be considered purposefully, resulting in a strategic commitment to spending. The role of economics in this process is to provide evidence demonstrating that information and support can be provided cost effectively to individuals to change their lifestyles thus avoiding lifestyle related morbidity and mortality. There is growing evidence that prevention programmes represent value for money using the currently accepted techniques and decision making metrics such as those advocated by NICE. Summary The issue here is not one of arguing that the economic evaluation of prevention and early intervention should be treated differently, although in some instances that may be appropriate, rather it is about making

  1. Psychosocial stress and strategies for managing adversity: measuring population resilience in New South Wales, Australia

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    Jacobs Jennifer

    2010-10-01

    Full Text Available Abstract Background Populations around the world are facing an increasing number of adversities such as the global financial crisis, terrorism, conflict, and climate change. The aim of this paper was to investigate self-reported strategies and sources of support used to get through "tough times" in an Australian context and to identify patterns of response in the general population and differences in potentially vulnerable subgroups. Methods Data were collected through a cross-sectional survey of the New South Wales population in Australia. The final sample consisted of 3,995 New South Wales residents aged 16 years and above who responded to the question: "What are the things that get you through tough times?" Results Respondents provided brief comments that were coded into 14 main subject-area categories. The most frequently reported responses were family and self (52%; friends and neighbors (21%; use of positive emotional and philosophical strategies (17%, such as sense of humor, determination, and the belief that things would get better; and religious beliefs (11%. The responses of four population subgroups were compared, based on gender, household income, level of psychological distress, and whether a language other than English was spoken at home. Women reported greater use of friends and neighbors and religious or spiritual beliefs for support, whereas men reported greater use of drinking/smoking and financial supports. Those with lower incomes reported greater reliance on positive emotional and philosophical strategies and on religious or spiritual beliefs. Those with high levels of psychological distress reported greater use of leisure interests and hobbies, drinking/smoking, and less use of positive lifestyle strategies, such as adequate sleep, relaxation, or work/life balance. Those who spoke a language other than English at home were less likely to report relying on self or others (family/friends or positive emotional and

  2. Psychosocial stress and strategies for managing adversity: measuring population resilience in New South Wales, Australia.

    Science.gov (United States)

    Taylor, Melanie; Barr, Margo; Stevens, Garry; Bryson-Taylor, Donald; Agho, Kingsley; Jacobs, Jennifer; Raphael, Beverley

    2010-10-14

    Populations around the world are facing an increasing number of adversities such as the global financial crisis, terrorism, conflict, and climate change. The aim of this paper was to investigate self-reported strategies and sources of support used to get through "tough times" in an Australian context and to identify patterns of response in the general population and differences in potentially vulnerable subgroups. Data were collected through a cross-sectional survey of the New South Wales population in Australia. The final sample consisted of 3,995 New South Wales residents aged 16 years and above who responded to the question: "What are the things that get you through tough times?" Respondents provided brief comments that were coded into 14 main subject-area categories. The most frequently reported responses were family and self (52%); friends and neighbors (21%); use of positive emotional and philosophical strategies (17%), such as sense of humor, determination, and the belief that things would get better; and religious beliefs (11%). The responses of four population subgroups were compared, based on gender, household income, level of psychological distress, and whether a language other than English was spoken at home. Women reported greater use of friends and neighbors and religious or spiritual beliefs for support, whereas men reported greater use of drinking/smoking and financial supports. Those with lower incomes reported greater reliance on positive emotional and philosophical strategies and on religious or spiritual beliefs. Those with high levels of psychological distress reported greater use of leisure interests and hobbies, drinking/smoking, and less use of positive lifestyle strategies, such as adequate sleep, relaxation, or work/life balance. Those who spoke a language other than English at home were less likely to report relying on self or others (family/friends) or positive emotional and philosophical strategies to get through tough times

  3. Consistent bone marrow-derived cell mobilization following repeated short courses of granulocyte-colony-stimulating factor in patients with amyotrophic lateral sclerosis: results from a multicenter prospective trial.

    Science.gov (United States)

    Tarella, Corrado; Rutella, Sergio; Gualandi, Francesca; Melazzini, Mario; Scimè, Rosanna; Petrini, Mario; Moglia, Cristina; Ulla, Marco; Omedé, Paola; Bella, Vincenzo La; Corbo, Massimo; Silani, Vincenzo; Siciliano, Gabriele; Mora, Gabriele; Caponnetto, Claudia; Sabatelli, Mario; Chiò, Adriano

    2010-01-01

    The aim of this study was to evaluate and characterize the feasibility and safety of bone marrow-derived cell (BMC) mobilization following repeated courses of granulocyte-colony stimulating factor (G-CSF) in patients with amyotrophic lateral sclerosis (ALS). Between January 2006 and March 2007, 26 ALS patients entered a multicenter trial that included four courses of BMC mobilization at 3-month intervals. In each course, G-CSF (5 microg/kg b.i.d.) was administered for four consecutive days; 18% mannitol was also given. Mobilization was monitored by flow cytometry analysis of circulating CD34(+) cells and by in vitro colony assay for clonogenic progenitors. Co-expression by CD34(+) cells of CD133, CD90, CD184, CD117 and CD31 was also assessed. Twenty patients completed the four-course schedule. One patient died and one refused to continue the program before starting the mobilization courses; four discontinued the study protocol because of disease progression. Overall, 89 G-CSF courses were delivered. There were two severe adverse events: one prolactinoma and one deep vein thrombosis. There were no discontinuations as a result of toxic complications. Circulating CD34(+) cells were monitored during 85 G-CSF courses and were always markedly increased; the range of median peak values was 41-57/microL, with no significant differences among the four G-CSF courses. Circulating clonogenic progenitor levels paralleled CD34(+) cell levels. Most mobilized CD34(+) cells co-expressed stem cell markers, with a significant increase in CD133 co-expression. It is feasible to deliver repeated courses of G-CSF to mobilize a substantial number of CD34(+) cells in patients with ALS; mobilized BMC include immature cells with potential clinical usefulness.

  4. William Wales and the 1769 transit of Venus: puzzle solving and the determination of the astronomical unit

    Science.gov (United States)

    Metz, Don

    2009-05-01

    According to Thomas Kuhn, a significant part of “normal science” is the fact gathering, empirical work which is intended to illustrate an existing paradigm. Some of this effort focuses on the determination of physical constants such as the astronomical unit (AU). For Kuhn, normal science is also what prepares students for membership in a particular scientific community and is embodied in some form in our science textbooks. However, neither Kuhn nor the textbook says much about the individuals who practice normal science, especially those who had been relegated to the “hack” duties of long and arduous measurement and calculation. In this paper, to provide a context for students of astronomy, I will outline the story of the determination of the AU and in particular the contribution of William Wales, an obscure British astronomer. Wales, toiling in the shadow of Halley (of Halley’s comet fame), Mason and Dixon (of Mason and Dixon line fame) and the infamous Captain Cook endured a brutal winter in northern Canada for a brief glimpse of the 1769 transit of Venus. In the end, Wales supplied one small piece of the puzzle in the determination of the AU and he exemplified the human spirit and persistence of a Kuhnian “puzzle solver”.

  5. Similarities and Differences of the Emerging Prison Problems in England and Wales vs. Kosovo: a Sociological and Criminological Perspective

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    MSc. Arben Lubach

    2015-06-01

    Full Text Available Prisons are probably the most debatable institutions within the Criminal Justice System in any given country and as such demand contemporary explanation and understanding. Despite the fact that prisons affect the life of many people, not only of those incarcerated but also of their families and friends, nevertheless they do not receive the necessary attention; instead they remain the most enigmatic and less interesting organizations amongst the Criminal Justice System in general. This paper, by using a literature review approach, looks into some of the most important debates, similarities and differences respectively, about prisons in England and Wales, and Kosovo. Whilst most of the problems both countries face are of similar nature, Kosovo nevertheless faces some additional problems which are not visible in the England and Wales prisons. The paper further examines the causes of these problems in the Kosovo prisons and the involvement of the international community and their efforts in assisting Kosovo in fixing the problems in the field of corrections as part of the Kosovo state-building process. The paper will show that both countries face difficulties with similar problem areas such as overcrowding, running costs, and so on. However, compared to England and Wales, the problems Kosovo prison system is facing are of a more serious and complicated nature which require serious involvement of the Kosovo government and policy makers as well as the international community which has been present in Kosovo since 1999.

  6. A Comparison of Substance Abuse and Mental Illness in Male Offenders in Jamaica and England and Wales

    Directory of Open Access Journals (Sweden)

    CA Sewell

    2015-03-01

    Full Text Available Background: The present study sought to determine the prevalence of substance abuse, mental illness, sociodemographics and clinical characteristics of mentally ill offenders. These data were compared to data from the prison population in the United Kingdom. Method: This is a cross-sectional study of male, mentally ill offenders in two prisons in Jamaica, and four prisons in England and Wales. For the Jamaican sample, a psychopathology and forensic survey instrument was developed by the research personnel to extract specific information from the diagnostic interview. Data extraction was done over a one-year period. For the England and Wales sample, the participants were interviewed and assessed using various structured instruments. Results: The results indicate that approximately 18% of persons within the Jamaican prison population under study had a mental illness. Of this number, 57% of these persons had been previously diagnosed with a Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision (DSM IV-TR Axis 1 disorder. Substance abuse was the most frequently diagnosed DSM-IV Axis I disorder within both populations. The prevalence of mental illness found in the Jamaican prison population was approximately four times greater than the rate in the comparison population of England and Wales. Conclusions: There was an over-representation of mentally ill offenders in the Jamaican prison population. This is most likely linked to the lack of appropriate diversion programmes and a forensic mental hospital in Jamaica.

  7. The Diagnosis of Urinary Tract infection in Young children (DUTY): a diagnostic prospective observational study to derive and validate a clinical algorithm for the diagnosis of urinary tract infection in children presenting to primary care with an acute illness.

    Science.gov (United States)

    Hay, Alastair D; Birnie, Kate; Busby, John; Delaney, Brendan; Downing, Harriet; Dudley, Jan; Durbaba, Stevo; Fletcher, Margaret; Harman, Kim; Hollingworth, William; Hood, Kerenza; Howe, Robin; Lawton, Michael; Lisles, Catherine; Little, Paul; MacGowan, Alasdair; O'Brien, Kathryn; Pickles, Timothy; Rumsby, Kate; Sterne, Jonathan Ac; Thomas-Jones, Emma; van der Voort, Judith; Waldron, Cherry-Ann; Whiting, Penny; Wootton, Mandy; Butler, Christopher C

    2016-01-01

    BACKGROUND It is not clear which young children presenting acutely unwell to primary care should be investigated for urinary tract infection (UTI) and whether or not dipstick testing should be used to inform antibiotic treatment. OBJECTIVES To develop algorithms to accurately identify pre-school children in whom urine should be obtained; assess whether or not dipstick urinalysis provides additional diagnostic information; and model algorithm cost-effectiveness. DESIGN Multicentre, prospective diagnostic cohort study. SETTING AND PARTICIPANTS Children < 5 years old presenting to primary care with an acute illness and/or new urinary symptoms. METHODS One hundred and seven clinical characteristics (index tests) were recorded from the child's past medical history, symptoms, physical examination signs and urine dipstick test. Prior to dipstick results clinician opinion of UTI likelihood ('clinical diagnosis') and urine sampling and treatment intentions ('clinical judgement') were recorded. All index tests were measured blind to the reference standard, defined as a pure or predominant uropathogen cultured at ≥ 10(5) colony-forming units (CFU)/ml in a single research laboratory. Urine was collected by clean catch (preferred) or nappy pad. Index tests were sequentially evaluated in two groups, stratified by urine collection method: parent-reported symptoms with clinician-reported signs, and urine dipstick results. Diagnostic accuracy was quantified using area under receiver operating characteristic curve (AUROC) with 95% confidence interval (CI) and bootstrap-validated AUROC, and compared with the 'clinician diagnosis' AUROC. Decision-analytic models were used to identify optimal urine sampling strategy compared with 'clinical judgement'. RESULTS A total of 7163 children were recruited, of whom 50% were female and 49% were < 2 years old. Culture results were available for 5017 (70%); 2740 children provided clean-catch samples, 94% of whom were ≥ 2 years old

  8. Psychophysiology of prospective memory.

    Science.gov (United States)

    Rothen, Nicolas; Meier, Beat

    2014-01-01

    Prospective memory involves the self-initiated retrieval of an intention upon an appropriate retrieval cue. Cue identification can be considered as an orienting reaction and may thus trigger a psychophysiological response. Here we present two experiments in which skin conductance responses (SCRs) elicited by prospective memory cues were compared to SCRs elicited by aversive stimuli to test whether a single prospective memory cue triggers a similar SCR as an aversive stimulus. In Experiment 2 we also assessed whether cue specificity had a differential influence on prospective memory performance and on SCRs. We found that detecting a single prospective memory cue is as likely to elicit a SCR as an aversive stimulus. Missed prospective memory cues also elicited SCRs. On a behavioural level, specific intentions led to better prospective memory performance. However, on a psychophysiological level specificity had no influence. More generally, the results indicate reliable SCRs for prospective memory cues and point to psychophysiological measures as valuable approach, which offers a new way to study one-off prospective memory tasks. Moreover, the findings are consistent with a theory that posits multiple prospective memory retrieval stages.

  9. Sexual Diversity in the Judiciary in England and Wales; Research on Barriers to Judicial Careers

    Directory of Open Access Journals (Sweden)

    Leslie J. Moran

    2013-12-01

    Full Text Available Debates about the diversity of the judiciary in the UK have been dominated by gender, race and ethnicity. Sexuality is notable by its absence and is perceived to pose particular challenges. It is usually missing from the list of diversity categories. When present, its appearance is nominal. One effect of this has been a total lack of official data on the sexual composition of the judiciary. Another is the gap in research on the barriers to the goal of a more sexually diverse judiciary. In 2008 the Judicial Appointment Commission (JAC for England and Wales undertook research to better understand the challenges limiting progress towards judicial diversity. A central gaol of the project was to investigate barriers to application for judicial appointment across different groups defined by “sex, ethnicity and employment status”. Sexual orientation was again noticeable by its absence. Its absence was yet another missed opportunity to recognise and take seriously this strand of diversity. This study is based on a response to that absence. A stakeholder organisation, InterLaw Diversity Forum for lesbian gay bisexual and transgender networks in the legal services sector, with the JAC’s approval, used their questionnaire and for the first time asked lesbian, gay, bisexual and transgender lawyers about the perceptions and experiences of barriers to judicial appointment. This paper examines the findings of that unique research and considers them in the light of the initial research on barriers to judicial appointment and subsequent developments.

  10. Operational practices associated with foodborne disease outbreaks in the catering industry in England and Wales.

    Science.gov (United States)

    Jones, Sarah L; Parry, Sharon M; O'Brien, Sarah J; Palmer, Stephen R

    2008-08-01

    Catering businesses continue to be the most common setting for foodborne disease outbreaks. In a study of catering businesses in England and Wales, operational practices relating to the supply, preparation, and service of food in 88 businesses associated with outbreaks were compared with those practices at 88 control businesses. Operational practices did not differ significantly between case and control businesses but larger small medium-size enterprise (SME) businesses were more likely to be associated with foodborne disease outbreaks than were micro-SME businesses. Businesses associated with outbreaks of Salmonella infection were less likely to use local or national suppliers but instead used regional suppliers, especially for eggs. This practice was the only significantly independent operational practice associated with outbreaks of Salmonella infection. Regional egg suppliers also were more likely to be used by businesses associated with outbreaks attributed to food vehicles containing eggs. Businesses associated with egg-associated outbreaks were less likely to use eggs produced under an approved quality assurance scheme, suggesting that the underlying risk associated with using regional suppliers may relate to the use of contaminated eggs.

  11. The historical development of health care law and bioethics in England and Wales: a symbiotic relationship?

    Science.gov (United States)

    Owusu-Dapaa, Ernest

    2014-04-01

    The paper explores the backward and forward linkage between HCL and bioethics. Indeed, the relationship between the two is so close that it can be considered one of symbiosis. This is particularly the case when an account is taken of how HCL and bioethics positively benefitted from each other in diverse ways during their development into their present status as discrete disciplines. In the first place, the aftermath of the Second World War, such as the Nuremberg trial and unprecedented medical experiment scandals in the 1960s/70s fuelled the increasing participation of lay scholars in exploring and critiquing medical ethics which culminated in the emergence ofbioethics.2 This in turn facilitated the evolution of HCL as a discipline, since academic lawyers involved in early bioethical discourse developed interest in exploring the interface between law and bioethics at the same time that society was waking up to the ethical implications of medical advances. As HCL emerged as a discrete discipline, it consolidated the status of bioethics as a field of inquiry by projecting the relevance of the latter in adjudication of novel cases with significant slippery moral undertones. Thus, the chicken and egg paradox finds a perfect reflection in the emergence of health care law and bioethics in England and Wales.

  12. Monitoring and Evaluation of Human Trafficking Partnerships in England and Wales

    Directory of Open Access Journals (Sweden)

    Ruth Van Dyke

    2017-04-01

    Full Text Available In the United Kingdom, human trafficking and, more recently, modern slavery has been pushed up the political and policy agenda. At the same time, partnership working has been promoted at international and national levels in order to encourage a more holistic response to trafficking. This article examines the nature of the evidence collected to monitor and evaluate the activities and outcomes of organisations involved in a number of human trafficking partnerships in England and Wales. Underpinning this analysis is the ‘4 Ps’ approach to tackling human trafficking: Prevention, Protection, Prosecution and Partnership. Based on interviews with a variety of actors working in different partner bodies, limitations of evidence in relation to both monitoring activities as well as evaluating outcomes emerged. These relate to inadequate data collection, lack of robust methods of data collection, untested assumptions, the complexity of gathering evidence which reflect human welfare oriented goals, and the sharing of evidence between partner organisations. A key finding is that current data and methods of data collection are inadequate for the purpose of measuring the effectiveness of anti-trafficking initiatives and partnerships. Another key finding is the way in which partnerships challenged received outcomes and expanded their focus beyond victims of trafficking or criminal justice goals. Finally, I explore whether criminal justice outcomes can be leveraged to foster deterrence, by interrogating what evidence might be needed.

  13. Formation of Stone-Wales edge: Multistep reconstruction and growth mechanisms of zigzag nanographene.

    Science.gov (United States)

    Dang, Jing-Shuang; Wang, Wei-Wei; Zheng, Jia-Jia; Nagase, Shigeru; Zhao, Xiang

    2017-10-05

    Although the existence of Stone-Wales (5-7) defect at graphene edge has been clarified experimentally, theoretical study on the formation mechanism is still imperfect. In particular, the regioselectivity of multistep reactions at edge (self-reconstruction and growth with foreign carbon feedstock) is essential to understand the kinetic behavior of reactive boundaries but investigations are still lacking. Herein, by using finite-sized models, multistep reconstructions and carbon dimer additions of a bared zigzag edge are introduced using density functional theory calculations. The zigzag to 5-7 transformation is proved as a site-selective process to generate alternating 5-7 pairs sequentially and the first step with largest barrier is suggested as the rate-determining step. Conversely, successive C 2 insertions on the active edge are calculated to elucidate the formation of 5-7 edge during graphene growth. A metastable intermediate with a triple sequentially fused pentagon fragment is proved as the key structure for 5-7 edge formation. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  14. The use of public health e-learning resources by pharmacists in Wales: a quantitative evaluation.

    Science.gov (United States)

    Evans, Andrew; Evans, Sian; Roberts, Debra

    2016-08-01

    The aim of this study was to examine how communicable disease e-learning resources were utilised by pharmacy professionals and to identify whether uptake of the resources was influenced by disease outbreaks. Retrospective analysis of routine data regarding the number of individuals completing e-learning resources and statutory notifications of communicable disease. A high proportion of pharmacy professionals in Wales (38.8%, n = 915/2357) accessed the resources; around one in six completed multiple resources (n = 156). The most commonly accessed were those where there had been a disease outbreak during the study period. There was a strong positive correlation between e-learning uptake and number of disease cases; this was observed both for measles and scarlet fever. Communicable disease e-learning appears to be an acceptable method for providing communicable disease information to pharmacy professionals. Study findings suggest that e-learning uptake is positively influenced by disease outbreaks this reflects well both on pharmacy professionals and on the e-learning resources themselves. © 2016 Royal Pharmaceutical Society.

  15. The cost of insulin-dependent diabetes mellitus (IDDM) in England and Wales.

    Science.gov (United States)

    Gray, A; Fenn, P; McGuire, A

    1995-12-01

    This study estimates the direct health and social care costs of insulin-dependent diabetes mellitus (IDDM) in England and Wales in 1992 to be 96 million pounds, or 1021 pounds per person in a population with IDDM estimated at 94,000 individuals. These costs include insulin maintenance, hospitalization, GP and out-patient consultations, renal replacement therapy, and payments to informal carers. Expenditure is concentrated on younger age groups, with one-third of the total expended on those aged 0-24. Around one-half of the total costs can be directly attributed to IDDM, with the remainder associated with a range of complications of the disease. The single largest area of service expenditure is renal replacement therapy. The cost estimates are most sensitive to incidence rates of IDDM, numbers on dialysis and average duration of dialysis. A further 113 million pounds may be lost each year due to premature deaths resulting in lost productive contributions to the economy. The direct and indirect costs of IDDM are therefore significant. The cost of illness framework presented here should facilitate the economic evaluation of new and existing treatment regimens, which may improve value for money by reducing costs and/or increasing the quality or quantity of life for people with IDDM.

  16. Radiation and cancer in Wales. The biological consequences of low-level radiation

    International Nuclear Information System (INIS)

    Busby, C.C.

    1994-01-01

    available for the answers to these questions to be fairly certain. It is the power and money of the nuclear profiteers and their establishment which supresses it. The real answer is to think for yourself. What is the most likely cause of nuclear-power-related clustering of cancers? Have you yourself noticed changes in cancer and leukemia rates or in congenital illness among the people you know and in particular among young people in the last twenty years? What could be causing them? Look at the bone-cancer increases in Wales (Fig. 1.3 of this report). What could be the cause? Why did they suddenly ban atmospheric nuclear bomb testing in the 1960s? There is considerable evidence pointing to links between childhood cancer and other illness and nuclear isotopic pollution. The difficulty has always been that the nuclear establishment and its apologists, including governments, have sought to prevent such evidence from appearing in the literature or in the media. A further problem has been that there have been few occasions when studies could be made which unequivocally analysed population responses to radioactive pollutants. Recently, the High Court case in which the Sellafield leukemia victims sued BNFL was lost because the judge decided that the link could not formally be proved: almost on the basis of weighing evidence on a spring balance. For this reason, the developing evidence from the Wales Radiation Cancer Laboratory, and in particular the bone-cancer increase alluded to in the first edition of this book, has become a critical piece of evidence of causation: a smoking gun in the hands of the nuclear polluters. For there is no other confounding cause in this instance. Wales populations, which were exposed to high levels of Strontium-90 and Plutonium in the 1960s have developed a 400 per cent excess of bone cancer relative to the England control group, twenty years after the dose was delivered. Both isotopes are known to cause bone cancer in humans and in animals. These

  17. Radiation and cancer in Wales. The biological consequences of low-level radiation

    Energy Technology Data Exchange (ETDEWEB)

    Busby, C C

    1994-07-01

    available for the answers to these questions to be fairly certain. It is the power and money of the nuclear profiteers and their establishment which supresses it. The real answer is to think for yourself. What is the most likely cause of nuclear-power-related clustering of cancers? Have you yourself noticed changes in cancer and leukemia rates or in congenital illness among the people you know and in particular among young people in the last twenty years? What could be causing them? Look at the bone-cancer increases in Wales (Fig. 1.3 of this report). What could be the cause? Why did they suddenly ban atmospheric nuclear bomb testing in the 1960s? There is considerable evidence pointing to links between childhood cancer and other illness and nuclear isotopic pollution. The difficulty has always been that the nuclear establishment and its apologists, including governments, have sought to prevent such evidence from appearing in the literature or in the media. A further problem has been that there have been few occasions when studies could be made which unequivocally analysed population responses to radioactive pollutants. Recently, the High Court case in which the Sellafield leukemia victims sued BNFL was lost because the judge decided that the link could not formally be proved: almost on the basis of weighing evidence on a spring balance. For this reason, the developing evidence from the Wales Radiation Cancer Laboratory, and in particular the bone-cancer increase alluded to in the first edition of this book, has become a critical piece of evidence of causation: a smoking gun in the hands of the nuclear polluters. For there is no other confounding cause in this instance. Wales populations, which were exposed to high levels of Strontium-90 and Plutonium in the 1960s have developed a 400 per cent excess of bone cancer relative to the England control group, twenty years after the dose was delivered. Both isotopes are known to cause bone cancer in humans and in animals. These

  18. The Challenge Posed by Geomagnetic Activity to Electric Power Reliability: Evidence From England and Wales

    Science.gov (United States)

    Forbes, Kevin F.; St. Cyr, O. C.

    2017-10-01

    This paper addresses whether geomagnetic activity challenged the reliability of the electric power system during part of the declining phase of solar cycle 23. Operations by National Grid in England and Wales are examined over the period of 11 March 2003 through 31 March 2005. This paper examines the relationship between measures of geomagnetic activity and a metric of challenged electric power reliability known as the net imbalance volume (NIV). Measured in megawatt hours, NIV represents the sum of all energy deployments initiated by the system operator to balance the electric power system. The relationship between geomagnetic activity and NIV is assessed using a multivariate econometric model. The model was estimated using half-hour settlement data over the period of 11 March 2003 through 31 December 2004. The results indicate that geomagnetic activity had a demonstrable effect on NIV over the sample period. Based on the parameter estimates, out-of-sample predictions of NIV were generated for each half hour over the period of 1 January to 31 March 2005. Consistent with the existence of a causal relationship between geomagnetic activity and the electricity market imbalance, the root-mean-square error of the out-of-sample predictions of NIV is smaller; that is, the predictions are more accurate, when the statistically significant estimated effects of geomagnetic activity are included as drivers in the predictions.

  19. Access to yellow fever travel vaccination centres in England, Wales, and Northern Ireland: A geographical study.

    Science.gov (United States)

    Petersen, Jakob; Simons, Hilary; Patel, Dipti

    More than 700,000 trips were made by residents in England, Wales, and Northern Ireland (EWNI) in 2015 to tropical countries endemic for yellow fever, a potentially deadly, yet vaccine-preventable disease transmitted by mosquitoes. The aim of this study was to map the geographical accessibility of yellow fever vaccination centres (YFVC) in EWNI. The location of 3208 YFVC were geocoded and the average geodetic distance to nearest YFVC was calculated for each population unit. Data on trips abroad and centres were obtained regionally for EWNI and nationally for the World Top20 countries in terms of travel. The mean distance to nearest YFVC was 2.4 km and only 1% of the population had to travel more than 16.1 km to their nearest centre. The number of vaccines administered regionally in EWNI was found correlated with the number of trips to yellow fever countries. The number of centres per 100,000 trips was 6.1 in EWNI, which was below United States (12.1) and above the rest of Top20 countries. The service availability was in line with demand regionally. With the exception of remote, rural areas, yellow fever vaccination services were widely available with only short distances to cover for the travelling public. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

  20. A Review of the Impact of the Human Rights in Healthcare Programme in England and Wales.

    Science.gov (United States)

    Dyer, Lindsey

    2015-12-10

    This article provides the background to an analysis of the Human Rights in Healthcare Programme in England and Wales. Using evidence from source materials, summary publications, and official reports, it charts a small but important change in the relationship between health and human rights and shows how a small number of National Health Service organizations used a human rights-based approach (HRBA) to develop resources aimed at improving the quality of health services and health outcomes. Through a case study of one participating organization, it examines the development of approaches to measuring the outcomes and impacts of HRBAs. The article argues that because of the way the Programme was set up, it is not likely to provide the level of evidence of impact required to bring about a profound change in the relationship between human rights and health care. There is a need for a different approach that considers the big human rights questions that need to be asked. Copyright © 2015 Dyer. This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

  1. Morphological change on the River Towy, Wales assessed using aerial photogrammetry

    Science.gov (United States)

    Ahmed, Joshua; Hodge, Michael

    2017-04-01

    The dynamic nature of meandering channels has fascinated geomorphologists for decades; with the onset of remote sensing, and technological advances in field equipment, scientists are able to capture high-resolution data from the Earth's surface using cost-effective techniques that require minimal manual labour. Here we present a morphological assessment of three meander bends on the River Towy, Wales, using aerial photography captured by the Welsh Assembly Government and supplemented by data captured by a UAV. Migration rates and changes in channel length were measured between 1969 and 2016 and compared to a coupled discharge record to quantify the effects of discharge variability on the morphological evolution of the channel. A short-term (seasonal) assessment of channel change was conducted by comparing sub-metre resolution 3D point cloud and digital elevation models, generated using a UAV and Structure-from-Motion (SfM) photogrammetry. Our results suggest that discharge variability plays a crucial role in controlling the evolution of meandering planforms and can be an effective means of excavating floodplain material over relatively short timescales, although erosion rates can be suppressed by bankline roughness, which effectively disrupts outwardly directed flow momentum. These findings have implications for land managers and those modelling the effects of climate change on hydrological regimes which are ultimately used to forecast channel planform changes. Additionally, our results demonstrate the potential of low-cost field surveying techniques in producing high resolution models of landscape change.

  2. Pathogens as Predictors of Honey Bee Colony Strength in England and Wales.

    Science.gov (United States)

    Budge, Giles E; Pietravalle, Stéphane; Brown, Mike; Laurenson, Lynn; Jones, Ben; Tomkies, Victoria; Delaplane, Keith S

    2015-01-01

    Inspectors with the UK National Bee Unit were asked for 2007-2008 to target problem apiaries in England and Wales for pathogen screening and colony strength measures. Healthy colonies were included in the sampling to provide a continuum of health conditions. A total of 406 adult bee samples was screened and yielded 7 viral, 1 bacterial, and 2 microsporidial pathogens and 1 ectoparasite (Acarapis woodi). In addition, 108 samples of brood were screened and yielded 4 honey bee viruses. Virus prevalence varied from common (deformed wing virus, black queen cell virus) to complete absence (Israeli acute paralysis virus). When colonies were forced into one of two classes, strong or weak, the weak colonies contained more pathogens in adult bees. Among observed pathogens, only deformed wing virus was able to predict colony strength. The effect was negative such that colonies testing positive for deformed wing virus were likely to have fewer combs of bees or brood. This study constitutes the first record for Nosema ceranae in Great Britain. These results contribute to the growing body of evidence linking pathogens to poor honey bee health.

  3. Humid to arid to subhumid vegetation shift on Pilliga Sandstone, Ulungra Springs, New South Wales

    Science.gov (United States)

    Dodson, J. R.; Wright, R. V. S.

    1989-09-01

    The Pilliga Sandstone region of the northwest slope of New South Wales has a natural vegetation cover of sclerophyllous relatively closed to open forests with a largely heathy understorey, and a warm, subhumid and continental climate. Pollen analysis of spring-fed deposits gives a vegetation history extending from at least 30,000 yr B.P. to the late Holocene. Tree pollen became scarce after about 25,000 yr B.P. and an assemblage dominated by Chenopodiaceae, Liguliflorae, Tubuliflorae, and probably Poaceae developed. No similar assemblage is known from present pollen rain studies carried out in Australia. However, it clearly represents a treeless open shrub-steppe formation and therefore an arid or semiarid environment. The site thus provides evidence of an eastward late Pleistocene extension of the arid zone in Australia, and is the first full-glacial vegetation record between 20° and 35° latitude in Australia. The present vegetation cover did not become reestablished until the beginning of the Holocene, which raises questions about the form in which Pilliga Sandstone vegetation survived full-glacial conditions.

  4. Sedentary behaviour, physical activity and weight problems in adolescents in Wales.

    Science.gov (United States)

    Elgar, F J; Roberts, C; Moore, L; Tudor-Smith, C

    2005-06-01

    We studied the prevalence and stability of overweight and obesity in a cohort of adolescents, and the effects of sedentary behaviour and physical activity on changes in body mass. The study also examined the extent to which physical activity mediated the relationship between sedentary behaviour and body mass. Four-year cohort study. The study was part of the Health Behaviour of School-aged Children Study that took place in Wales between 1994 and 1998. Body height and weight measurements and self-report data on sedentary behaviour, physical activity and psychosocial adjustment were collected from 355 adolescents on two occasions 4 years apart. The mean age of the sample at baseline was 12.30 (SD=6.30) years. Weight conditions (underweight, overweight and obesity) and body mass were moderately stable over the interval. Regression analyses showed that sedentary behaviour at Time 1 predicted body mass at Time 2, while physical activity predicted a change in body mass over time. The influence of sedentary behaviour on body mass was not found to be mediated by physical activity. However, weight problems in Year 7 coincided with getting bullied, bullying others, and feeling left out of things. Obesity was also related to snacking and skipping breakfast. Sedentary behaviour and physical activity in early adolescence both influenced body mass in late adolescence. Results indicated that promoting healthy diets and physical activities may have long-term health benefits for young people.

  5. Understanding Revenge Pornography: A National Survey of Police Officers and Staff in England and Wales.

    Science.gov (United States)

    Bond, Emma; Tyrrell, Katie

    2018-02-01

    Online abuse, facilitated via social media and mobile technologies, has recently attracted considerable academic attention. The nonconsensual sharing of intimate images-revenge pornography-can have a devastating effect on victims, is a global problem, and constitutes interpersonal violence. The national helpline in the United Kingdom has now received over 7,000 calls. In the United Kingdom, new legislation making revenge pornography a crime was introduced in 2014, yet the police do not always respond appropriately to victims. This article presents the findings of a national online survey of police understanding of revenge pornography, undertaken in the United Kingdom in March 2017. The study set out to investigate police knowledge of revenge pornography legislation, their confidence in responding to cases of revenge pornography, and what level of training they had received. A total of 783 members of the police force responded to the survey and, to the authors' knowledge, this the first study to seek to quantify the understanding of revenge pornography by police officers and staff in England and Wales. The findings suggest that the police in the United Kingdom have a limited understanding of revenge pornography legislation and lack confidence both in investigating cases and in effectively responding to victims. The implications of the study demonstrate that there is an urgent need for training across police forces to ensure that cases of revenge pornography are appropriately responded to, victims are safeguarded, and offenders brought to justice.

  6. Homicide-suicide (dyadic death), homicide, and firearms use in England and Wales.

    Science.gov (United States)

    Travis, Angela R; Johnson, Luke J; Milroy, Christopher M

    2007-12-01

    Homicide-suicide forms a distinct form of homicide. An analysis of cases in the Yorkshire and Humberside region of England between 1991 and 2005 revealed 37 episodes with 42 victims. Previous studies have shown a high rate of use of firearms. Over the last 2 decades firearms legislation has become more restrictive. In this study all assailants were male, mean age 46.8 years. The commonest method of homicide was strangulation (36%) with 16% killed by firearms. This is a reduction compared with a previous study in the same region. All killers who shot their victims killed themselves with firearms. There were no multiple killings with firearms in this study and no stranger killings. Hanging was the commonest method of suicide. During the same period the use of firearms as a method of homicide increased in England and Wales with handguns, the most common weapon. Nationally, suicide after homicide has remained at a similar rate over the half century and is an uncommon phenomenon. Firearms use remains low in both homicide and homicide-suicide episodes in England, and further analysis is required to determine changes in patterns of killing.

  7. Annual vaccine-preventable disease report for New South Wales, Australia, 2014

    Directory of Open Access Journals (Sweden)

    Nathan Saul

    2017-06-01

    Full Text Available This report provides an epidemiological description of selected vaccine-preventable diseases in New South Wales (NSW, Australia, for 2014 to inform ongoing disease monitoring and control efforts. A trend of increasing pertussis notifications was observed, beginning midway through 2014 with the highest disease rates in the 5–9 year age group. Measles notifications increased to 67 cases in 2014 from 34 cases in 2013. Measles cases were associated with travel-related importations—predominantly from the Philippines—and secondary transmission increased compared to 2013 involving three main disease clusters. Notifications of invasive meningococcal disease continued to decline across the state with meningococcal B remaining the most common serogroup in NSW. Increasing rates of pertussis notifications from mid-2014 may indicate the beginning of an epidemic, ending the period of low transmission observed in 2013 and the first half of 2014. An increase in measles notifications in 2014, including secondary transmission, indicates the continued need for public health actions including robust follow-up and awareness campaigns.

  8. Care: what it means to Iranian immigrants in New South Wales, Australia.

    Science.gov (United States)

    Omeri, A

    1997-01-01

    Discoveries of linguistic terms relating to care/caring can create better understanding of diversities in expression and experiences of care of different cultures. Such linguistic understandings and discovery of "meaning-in-context" can enhance communication toward unity in light of diversity. In order to gain an understanding of expression of care/caring for Iranian immigrants in New South Wales, Australia, linguistic terms in the Persian language as discovered are described. The study, conceptualised within Leininger's theory of Culture Care diversity and universality led to the discovery of 31 linguistic care terms in the Persian language, reflecting the emic view of care for Iranian Immigrants in multicultural Australia. Using Leininger's ethnonursing research method and in depth naturalistic interviews, five types of care were abstracted from recurrent patterning and saturation according to type and meaning of care were discovered and described. The five categories describe care as: action; (hamoyat, parastari), thoughts; (ba-fakr-ham-boodan), reflecting family ties; (hambastegie), care as being Iranian, reflecting Iranian identity; (inhamani, hamonandi). Finally, care as related to context and expressed in safety and peace; (amnieyat, aramash), describing Australia as a safe and peaceful place to live. This paper will attempt to share an Iranian immigrants' emic view of care.

  9. The cost-effectiveness of vaccinating pregnant women against seasonal influenza in England and Wales.

    Science.gov (United States)

    Jit, Mark; Cromer, Deborah; Baguelin, Marc; Stowe, Julia; Andrews, Nick; Miller, Elizabeth

    2010-12-10

    We assessed the cost-effectiveness of vaccinating pregnant women against seasonal influenza in England and Wales, taking into account the timing of vaccination relative to both the influenza season and trimester of pregnancy. Women were assumed to be vaccinated in their second or third trimester. Vaccination between September and December was found to have an incremental cost-effectiveness ratio of £23,000 per quality adjusted life year (QALY) (95% CI £10,000-£140,000) if it is assumed that infants are partially protected through their mothers, and of £28,000 per QALY gained (95% CI £13,000-£200,000) if infants are not protected. If some vaccine protection lasts for a second season, then the ratio is only £15,000 per QALY gained (95% CI £6,000-£93,000). Most of the benefit of vaccination is in preventing symptomatic episodes, regardless of health care resource use. Extending vaccination beyond December is unlikely to be cost-effective unless there is good protection into a second influenza season. Key sources of uncertainty are the cost of vaccine delivery and the quality of life detriment due to a clinically apparent episode of confirmed influenza. The cost of vaccine purchase itself is relatively low. Copyright © 2010 Elsevier Ltd. All rights reserved.

  10. Hazardous alcohol consumption in non-aboriginal male inmates in New South Wales.

    Science.gov (United States)

    Field, Courtney

    2018-03-12

    Purpose The purpose of this paper is to examine correlates and predictors of hazardous drinking behaviour, that may be considered evidence of generalised strain, in a sample of incarcerated non-Aboriginal males in New South Wales, Australia. Design/methodology/approach Data were collected from 283 non-Aboriginal male inmates as part of a larger epidemiological survey of inmates in NSW undertaken in 2015 by the Justice Health and Forensic Mental Health Network. Data relating to a range of social factors were selected with reference to relevant literature and assessed with regards their predictive value for scores from the Alcohol Use Disorders Identification Test (AUDIT). To facilitate regression analysis, variables were logically organised into historical factors or adult factors. Findings Almost all participants reported some history of alcohol consumption. Hazardous drinking was common among participants. While parental alcohol problems and adult drug use were the only correlates of AUDIT scores, parental misuse of alcohol was shown to be an important predictor of AUDIT scores in regression analysis. The role of parent gender was inconclusive. Previous incarceration as an adult, employment status, and drug use as an adult also predicted AUDIT scores. Originality/value Alcohol abuse is common among inmates and the use of alcohol is implicated in the commission of many offences. A better understanding of its genesis may inspire novel approaches to treatment, leading to improved health outcomes for inmates.

  11. Gunpowder, the Prince of Wales's feathers and the origins of modern military surgery.

    Science.gov (United States)

    Pearn, John

    2012-04-01

    The history of military surgery claims many forebears. The first surgeon-soldiers were Homer's Machaon and Podalirius, followed a thousand years later by the Roman surgeons-general, Antonius Musa and Euphorbus; and later, e.g. Ambrose Paré, John Hunter and Sir John Pringle; and the 19th century innovators, Dominique-Jean Larrey (France), Friedrich von Esmarch (Prussia) and the Russian, Nikolai Pirogoff. The singular feature that distinguished modern military surgery from its earlier practice was the use of gunpowder. It was one of two inventions (the other was printing) that by the empowerment of individuals, lifted Western humankind from the medieval to the modern era. Research of primary and secondary archives. Gunpowder was first used in European warfare at Algeceras (1344-1368). Hitherto, the destruction of tissue had been the result of (relative) low-energy wounding with tissue damage caused by incisional or crushing wounds. The founder of modern surgery, Master John of Arderne (1307-1380), wrote of his experience gained as a military surgeon on the battlefield at Crecy (1346). Following Crecy, Arderne was the only chronicler who described the origins of the Prince of Wales's feathers as a royal and later commercial symbol, and the motto 'Ich Dien', 'I serve', as that of hospitals in the Western World. Later advances in military surgery incorporated both clinical experimentation and the innovation of new systems of pre-hospital battlefield care. © 2012 The Author. ANZ Journal of Surgery © 2012 Royal Australasian College of Surgeons.

  12. Drug overdosage and other poisoning in Hong Kong--the Prince of Wales Hospital (Shatin) experience.

    Science.gov (United States)

    Chan, T Y; Critchley, J A; Chan, M T; Yu, C M

    1994-07-01

    From 1988 to 1991, 732 patients (91.1% Chinese) were admitted to four general medical wards at the Prince of Wales Hospital in Hong Kong with acute poisoning. The patients were predominantly female (68.9%) and relatively young (86.3% below the age of 40). Further analysis of 655 patients indicates that the vast majority of patients (96%) were admitted after self-poisoning with drugs or chemicals while 4% of cases were due to accidental poisoning. The main agents used by the former group included hypnotics/sedatives (33.1%), household products (15.7%), and analgesics (13.7%). There were nine deaths (1.4%). When compared to other Western countries, two important variations in the pattern of acute poisoning were seen. A substantial proportion of drugs ingested by our patients were not precisely identified. 'Dettol', a household product, was commonly used for self-poisoning in Hong Kong. Territory-wide studies of longer duration are needed to provide the physicians in Hong Kong with much needed information on the incidence and the pattern of acute poisoning.

  13. Pathogens as Predictors of Honey Bee Colony Strength in England and Wales.

    Directory of Open Access Journals (Sweden)

    Giles E Budge

    Full Text Available Inspectors with the UK National Bee Unit were asked for 2007-2008 to target problem apiaries in England and Wales for pathogen screening and colony strength measures. Healthy colonies were included in the sampling to provide a continuum of health conditions. A total of 406 adult bee samples was screened and yielded 7 viral, 1 bacterial, and 2 microsporidial pathogens and 1 ectoparasite (Acarapis woodi. In addition, 108 samples of brood were screened and yielded 4 honey bee viruses. Virus prevalence varied from common (deformed wing virus, black queen cell virus to complete absence (Israeli acute paralysis virus. When colonies were forced into one of two classes, strong or weak, the weak colonies contained more pathogens in adult bees. Among observed pathogens, only deformed wing virus was able to predict colony strength. The effect was negative such that colonies testing positive for deformed wing virus were likely to have fewer combs of bees or brood. This study constitutes the first record for Nosema ceranae in Great Britain. These results contribute to the growing body of evidence linking pathogens to poor honey bee health.

  14. The descriptive epidemiology of sports/leisure-related heat illness hospitalisations in New South Wales, Australia.

    Science.gov (United States)

    Finch, Caroline F; Boufous, Soufiane

    2008-01-01

    Sport-related heat illness has not been commonly studied from an epidemiological perspective. This study presents the descriptive epidemiology of sports/leisure-related heat illness hospitalisations in New South Wales, Australia. All in-patient separations from all acute hospitals in NSW during 2001-2004, with an International Classification of Diseases external cause of injury code indicating "exposure to excessive natural heat (X30)" or any ICD-10 diagnosis code in the range: "effects of heat and light (T67.0-T67.9)", were analysed. The sport/leisure relatedness of cases was defined by ICD-10-AM activity codes indicating involvement in sport/leisure activities. Cases of exposure to heat while engaged in sport/leisure were described by gender, year, age, principal diagnosis, type of activity/sport and length of stay. There were 109 hospital separations for exposure to heat while engaging in sport/leisure activity, with the majority occurring during the hottest months. The number of male cases significantly increased over the 4-year period and 45+ -year olds had the largest number of cases. Heat exhaustion was the leading cause of hospital separation (40% of cases). Marathon running, cricket and golf were the activities most commonly associated with heat-related hospitalisation. Ongoing development and refinement of expert position statements regarding heat illnesses need to draw on both epidemiological and physiological evidence to ensure their relevance to all levels of risk from the real world sport training and competition contexts.

  15. Mastery of fundamental movement skills among children in New South Wales: prevalence and sociodemographic distribution.

    Science.gov (United States)

    Okely, A D; Booth, M L

    2004-09-01

    Fundamental movement skills form the foundation for many of the specific motor skills employed in popular sports and leisure activities. Little data exist on the prevalence and socioeconomic distribution of fundamental movement skill mastery among young children in Australia. This study process-assessed performance on six fundamental movement skills in a randomly selected sample of students from Years 1 through 3 in the Sydney metropolitan area of New South Wales. The prevalence and sociodemographic distribution of mastery and near mastery for each skill and each skill component is reported for boys and girls in each school year. The findings revealed that the prevalence of mastery and near mastery of each of fundamental movement skill was generally low. Boys performed significantly better than girls in the run and in the four object-control skills (throw, catch, kick, and strike) whilst girls performed better than boys in the skip. There was no consistent association between prevalence of skill mastery and socio-economic status (SES), with only the kick and vertical jump for boys and catch, dodge, and vertical jump for girls differing across SES tertiles. Based on these results, we recommend that adequate curriculum time, resources, and professional development continue to be devoted to fundamental movement skills in NSW primary schools.

  16. Estimating the volatility of electricity prices: The case of the England and Wales wholesale electricity market

    International Nuclear Information System (INIS)

    Tashpulatov, Sherzod N.

    2013-01-01

    Price fluctuations that partially comove with demand are a specific feature inherent to liberalized electricity markets. The regulatory authority in Great Britain, however, believed that sometimes electricity prices were significantly higher than what was expected and, therefore, introduced price-cap regulation and divestment series. In this study, I analyze how the introduced institutional changes and regulatory reforms affected the dynamics of daily electricity prices in the England and Wales wholesale electricity market during 1990–2001. This research finds that the introduction of price-cap regulation did achieve the goal of lowering the price level at the cost of higher price volatility. Later, the first series of divestments is found to be successful at lowering price volatility, which however happens at the cost of a higher price level. Finally, this study also documents that the second series of divestments was more successful at lowering both the price level and volatility. - Author-Highlights: • The impact of regulation on the dynamics of electricity prices is examined. • Price-cap regulation has decreased the level at the cost of higher volatility. • The first series of divestments has reversed the trade-off. • The reversed trade-off is explained as an indication of tacit collusion. • The second series of divestments is found generally successful

  17. Epidemiological analysis of Salmonella clusters identified by whole genome sequencing, England and Wales 2014.

    Science.gov (United States)

    Waldram, Alison; Dolan, Gayle; Ashton, Philip M; Jenkins, Claire; Dallman, Timothy J

    2018-05-01

    The unprecedented level of bacterial strain discrimination provided by whole genome sequencing (WGS) presents new challenges with respect to the utility and interpretation of the data. Whole genome sequences from 1445 isolates of Salmonella belonging to the most commonly identified serotypes in England and Wales isolated between April and August 2014 were analysed. Single linkage single nucleotide polymorphism thresholds at the 10, 5 and 0 level were explored for evidence of epidemiological links between clustered cases. Analysis of the WGS data organised 566 of the 1445 isolates into 32 clusters of five or more. A statistically significant epidemiological link was identified for 17 clusters. The clusters were associated with foreign travel (n = 8), consumption of Chinese takeaways (n = 4), chicken eaten at home (n = 2), and one each of the following; eating out, contact with another case in the home and contact with reptiles. In the same time frame, one cluster was detected using traditional outbreak detection methods. WGS can be used for the highly specific and highly sensitive detection of biologically related isolates when epidemiological links are obscured. Improvements in the collection of detailed, standardised exposure information would enhance cluster investigations. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. 'Start the conversation': the New South Wales (Australia) family health history campaign.

    Science.gov (United States)

    Dunlop, K; Barlow-Stewart, K

    2010-01-01

    Evidence that family health history (FHH) informs recommendations for appropriate early detection strategies used for the prevention of many health conditions underscores the importance of optimizing a patient's knowledge of his/her personal FHH. For some conditions, FHH also underpins identifying those at potentially high risk for whom genetic testing may be possible and suitable to further inform the advice. The Family Health History Campaign 'Start the Conversation' was conducted in New South Wales (Australia) in August 2006 as a small state-wide media campaign with the aim of encouraging individuals to discuss and gather their FHH information about several conditions and report it to their doctor. Campaign development included consultations with consumers and primary care practitioners (general practitioners - GPs), development of campaign resources, and establishment of partnerships. Evaluation methodologies included community poll surveys pre- and post-campaign, a GP mail survey, and website usage analysis. While only 112/403 of the polled community reported hearing about the campaign in the media, 48% of those men and women were encouraged to start the conversation with their families. Limited findings from the GP survey respondents suggested they were engaged, made aware of the potential lack of patient knowledge about FHH and generated referral for several high-risk patients. Campaigns that use the media to encourage the community to take action and also engage the GPs can create a supportive environment that has the potential to increase the accuracy with reporting of FHH to maximize benefit for early detection and prevention.

  19. Stability and Electronic Properties of Hydrogenated Zigzag Carbon Nanotube Focused on Stone-Wales Defect

    International Nuclear Information System (INIS)

    Pan Li-Jun; Zhang Jie; Chen Wei-Guang; Tang Ya-Nan

    2015-01-01

    We present a first-principles study of the chemisorption of hydrogen on a Stone-Wales (SW) defective carbon nanotube (10,0). The investigated configurations include four configurations covering single defects and double defects. One hydrogen dimer adsorption is energetically favored on bonds shared by carbon heptagon-heptagon for configurations with the defect parallel to the tube axis compared with the carbon pentagon-hexagon sites for ones with a slanted defect. This different behavior is also demonstrated for hydrogen dimer chain adsorption, the favored site for the former ones is through the defect, which is the nearest neighbor site to defect for the latter ones. It is found that the energy band gaps of hydrogenated configurations may be enlarged or decreased by altering the adsorption site or defect position. The semiconductor-to-metal transition may occur for configurations with the defect or defects parallel to the tube axis due to low electronic localization. Our results highlight the interest of the interaction of multi-factor system by providing a detailed bond and position picture of a hydrogenated defective carbon nanotube (10,0). (paper)

  20. Emergency contraception. General practitioner knowledge, attitudes and practices in New South Wales.

    Science.gov (United States)

    Weisberg, E; Fraser, I S; Carrick, S E; Wilde, F M

    1995-02-06

    To assess the knowledge, attitudes and practices of general practitioners in New South Wales regarding the provision of emergency contraception. Randomised group comparison of 100 rural and 100 urban general practitioners (GPs) by questionnaire. Eighty-four rural and 76 urban GPs responded. More rural GPs were knowledgeable about emergency contraception than urban GPs (95% v. 78%), and more women knew about it than men. More urban GPs frequently prescribed emergency contraception than rural GPs (26% v. 6%) and female GPs prescribed it more readily than male GPs (22% v. 12%). There was great variation in the regimens prescribed, especially among rural GPs. Twenty-five per cent of urban GPs and 31% of rural GPs did not offer women information about emergency contraception, while 16% of both groups included such information in any discussion about contraceptive options, and 18% gave information only if requested by the woman. More than 60% of the GPs would provide information about emergency contraception as a back-up to use of barrier methods. The sex, attitude and knowledge of the GPs influence the likelihood of women being made aware of or being given emergency contraception in NSW. There is a need to further educate both the public and practitioners about emergency contraception.

  1. Energy performance ratings and house prices in Wales: An empirical study

    International Nuclear Information System (INIS)

    Fuerst, Franz; McAllister, Pat; Nanda, Anupam; Wyatt, Pete

    2016-01-01

    This paper investigates the effect of Energy Performance Certificate (EPC) ratings on residential prices in Wales. Drawing on a sample of approximately 192,000 transactions, the capitalisation of energy efficiency ratings into house prices is investigated using two approaches. The first adopts a cross-sectional framework to investigate the effect of EPC rating on price. The second approach applies a repeat-sales methodology to investigate the impact of EPC rating on house price appreciation. Statistically significant positive price premiums are estimated for dwellings in EPC bands A/B (12.8%) and C (3.5%) compared to houses in band D. For dwellings in band E (−3.6%) and F (−6.5%) there are statistically significant discounts. Such effects may not be the result of energy performance alone. In addition to energy cost differences, the price effect may be due to additional benefits of energy efficient features. An analysis of the private rental segment reveals that, in contrast to the general market, low-EPC rated dwellings were not traded at a significant discount. This suggests different implicit prices of potential energy savings for landlords and owner-occupiers.

  2. Asthma management in rural New South Wales: perceptions of health care professionals and people with asthma.

    Science.gov (United States)

    Cvetkovski, Biljana; Armour, Carol; Bosnic-Anticevich, Sinthia

    2009-08-01

    To investigate the perceptions and attitudes towards asthma management of general practitioners, pharmacists and people with asthma in a rural area. Qualitative semistructured interviews. Small rural centre in New South Wales. General practitioners, pharmacists and people with asthma in a rural area. General practitioners perceived that the patient provided a barrier to the implementation of optimal asthma services. They were aware that other health care professionals had a role in asthma management but were not aware of the details, particularly in relation to that of the pharmacist and would like to improve communication methods. Pharmacists also perceived the patient to be a barrier to the delivery of optimal asthma management services and would like to improve communication with the general practitioner. The impact of the rural environment for the health care professionals included workforce shortages, availability of support services and access to continuing education. People with asthma were satisfied with their asthma management and the service provided by the health care professionals and described the involvement of family members and ambulance officers in their overall asthma management. The rural environment was an issue with regards to distance to the hospital during an emergency. General practitioners and pharmacists confirmed their existing roles in asthma management while expressing a desire to improve communication between the two professions to help overcome barriers and optimise the asthma service delivered to the patient. The patient described minimal barriers to optimising asthma management, which might suggest that they might not have great expectations of asthma care.

  3. Insomnia management in prisons in England and Wales: a mixed-methods study.

    Science.gov (United States)

    Dewa, Lindsay H; Hassan, Lamiece; Shaw, Jenny J; Senior, Jane

    2017-06-01

    Insomnia in prison is common; however, research is limited regarding the management strategies that prison establishments employ. To address this knowledge gap, we conducted a survey to identify how insomnia is detected, diagnosed and treated in adult prisons in England and Wales. Telephone interviews with a purposive sample of health-care managers were then conducted. The survey was sent to all establishments holding adult prisoners, covering screening and assessment methods to detect insomnia; treatment options, both pharmacological and non-pharmacological; the importance of insomnia as a treatable condition; and staff training available. Eighty-four (73%) prisons completed the survey. Few had a stepped approach to insomnia management, as recommended by National Institute for Health and Care Excellence (NICE) guidelines. The most common treatments available were sleep hygiene education and medication, offered by 94 and 88% of respondents, respectively. Analysis of telephone interviews revealed four main themes: insomnia as a normal occurrence in prison; the problem of medication in prison; the negative impact of the prison environment; and effective management of insomnia in prison. The current findings suggest that logistical, ethical and security barriers and a lack of staff knowledge and training impact negatively on the management of insomnia in prison. © 2017 European Sleep Research Society.

  4. An ecological analysis of prison overcrowding and suicide rates in England and Wales, 2000-2014.

    Science.gov (United States)

    van Ginneken, Esther F J C; Sutherland, Alex; Molleman, Toon

    Prisoners are at a greatly increased risk of suicides compared to the general population. Differences in suicide risk can be partly explained by individual risk factors, but the contribution of prison characteristics remains unclear. Overcrowded prisons have higher suicide rates, but this may be related to prison function, security level, population size and turnover. The aim of the current study was to investigate the contribution of each of these prison characteristics to suicide rates, using data from the Ministry of Justice for adult prisons in England and Wales from 2000 to 2014. Negative binomial regression analysis showed that larger population size, higher turnover, higher security and public management were associated with higher suicide rates. When controlling for these factors, overcrowding was not found to be related to suicide rates. Questions remain about the causal mechanisms underlying variation in prison suicides and the impact of the lived experience of overcrowding. Further research is needed to examine the relative contribution of prison and prisoner characteristics to suicides. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Wind energy planning in England, Wales and Denmark: Factors influencing project success

    International Nuclear Information System (INIS)

    McLaren Loring, Joyce

    2007-01-01

    Land-use planning poses a significant barrier to the further development of on-shore wind energy in many countries. There has been increasing discussion regarding the use of public participation in the planning process in order to address concerns of local residents and ease conflicts. This research explores the dynamics of the planning process for wind energy in England, Wales and Denmark in order to better understand the factors influencing project success. Through 18 in-depth case studies, it investigates the degree of local community participation in the planning process and the stability of the network of individuals and organisations involved in the project to determine their relationship to the public's acceptance of the project and the planning outcome. The study draws on the frameworks of public participation in planning and actor-network theories in order to develop indicators of the level of community involvement and network formation for each case. The analysis discusses predictions made by the theoretical approaches as to the importance of these variables to the success of new projects. The results indicate that projects with high levels of participatory planning are more likely to be publicly accepted and successful. In addition, stable supporting networks are more likely to form. The presence of a stable network of supporters is not found to be related to project acceptance and success; however, the absence of a stable network of opponents is found to be necessary for project acceptance and success in receiving planning permission

  6. Radiation protection in the mineral sands industry in New South Wales

    International Nuclear Information System (INIS)

    Carter, M.W.; Coundouris, A.N.

    1993-01-01

    The mineral sands industry in New South Wales (NSW) mines and concentrates the heavy minerals ilmenite, rutile, zircon and monazite; principally for export. Mineral sands concentrates contain small quantities of thorium and uranium series radionuclides and therefore are radioactive. The protection of workers, the public and the environment is a responsibility of mine operators. NSW Government Departments administer legislation, grant approvals and specify conditions for radiation protection. A summary of the history and current size of the industry is presented, together with current legislative and licensing activities. The paper reviews available literature on radiation measurements in the East coast mineral sands industry and re-interprets the earlier data in the light of the contemporary methodology of dose assessment. Some unpublished information and the results of some new surveys are also presented. A comparison is made with results that have been reported from Western Australia. Procedures for reducing radiation exposures are discussed and areas of future information needs are suggested. 17 refs., 6 refs., 3 tabs

  7. Under-reporting of birth registrations in New South Wales, Australia

    Directory of Open Access Journals (Sweden)

    Xu Fenglian

    2012-12-01

    Full Text Available Abstract Background To determine the rates of birth registration over a five-year period in New South Wales (NSW and explore the factors associated with the rate of registration. Methods This is a cross-sectional study using linked population databases. The study population included all births of NSW residents in NSW between 2001 and 2005. Results Birth registration rates in NSW were 82.66% in the year of birth, 93.19% in the first year, 94.02% in the second, 94.56% in the third and 95.08% in the fourth year after birth. The non-registration of births was mainly associated with such factors as neonatal and postneonatal death (adjusted OR = 3.84, 95% CI: 3.23-4.57; being Indigenous (adjusted OR = 3.26, 95% CI: 3.10-3.43; maternal age 39 years (adjusted OR = 2.81, 95% CI: 2.72-2.90; low birthweight ( Conclusion Of birth in NSW, 4.92% were not registered by the fourth year after birth.

  8. Improved survival for non-Hodgkin lymphoma patients in New South Wales, Australia

    Directory of Open Access Journals (Sweden)

    O'Connell Dianne L

    2010-05-01

    Full Text Available Abstract Background We evaluated if the survival benefit of adding rituximab to standard chemotherapy for non-Hodgkin lymphoma (NHL observed in clinical trials has been experienced by an Australian NHL patient population. Methods NHL cases diagnosed in 1985-2004 in New South Wales (NSW were followed-up to the end of 2004. Rituximab prescription data were obtained from Medicare Australia. Using a Poisson regression model adjusted for age group, sex, NHL subtype and time period (1990-1994, 1995-1999 and 2000-2004, we estimated excess risk of death after a diagnosis of NHL. To give context to the survival trend, trends in incidence and mortality were also estimated. Results Compared with 1990-1994, after adjusting for age, sex and NHL subtype the relative excess risk of death was significantly lower (p Conclusion It is likely that some benefit of adding rituximab to the standard chemotherapy for NHL has been experienced at the population level.

  9. Homicides by older offenders in New South Wales between 1993 and 2010.

    Science.gov (United States)

    Reutens, Sharon; Nielssen, Olav; Large, Matthew

    2015-10-01

    Homicides by older people are rare and might differ from those committed by younger people. To investigate the characteristics of older homicide offenders in New South Wales (NSW), Australia. A systematic search of legal, criminological and media databases for cases of homicide committed by people in NSW aged 55 and over, during the 18 years from 1993 to 2010. Eighty-seven cases were identified through databases. Legal documents were obtained for 70 offenders, comprising about 5% of homicides committed in NSW in the period of the study. The proportions of male offenders and rates of firearm use were similar to other age groups. Twelve of the 14 homicides using guns occurred outside the metropolitan area. Older offenders were more likely to have cognitive impairment or psychotic illness. Victims were more likely to be female and in a domestic relationship with the offender. Homicide by an older person is rare, and more commonly involves a man killing a family member. Correctional facilities will increasingly have to consider the needs of older people serving long sentences. © The Royal Australian and New Zealand College of Psychiatrists 2015.

  10. Paragangliomas: Presentation and management by radiotherapy at the Prince of Wales Hospital

    International Nuclear Information System (INIS)

    Smee, Robert I.; Jayasekara, Jayana; Williams, Janet R.; Hanna, Claire

    2015-01-01

    Paragangliomas are commonly treated with surgery, while radiotherapy is reserved for those that are inoperable or have relapsed. However, this retrospective study aims to determine whether radiotherapy is a viable initial treatment for paragangliomas. Of 73 tumours researched, 44 were diagnosed and treated from January 1967 to December 2012 at the Radiation Oncology Department at the Prince of Wales Hospital and thus were eligible for analysis. Median follow-up time was 3.5 years with a range of 1 to 40 years. Thirty-four tumours were treated with radiotherapy only, and 10 tumours were treated with both surgical resection and radiotherapy. Local control and cause-specific survival were the primary end points measured. Five-year local control rate for the population of 44 lesions was 89%; it was 100% in the group treated by radiotherapy alone, but only 50% in the group treated by surgery followed by radiotherapy, with radiation used for salvage. The difference in control rates between these two subset groups was found to be statistically significant (P < 0.001). Cause-specific survival rates for this eligible population at 5 and 10 years were 98% and 90%, respectively. After initial radiotherapy, 4 patients had improved cranial nerve function, there was clinical improvement in tinnitus, and one new cranial nerve deficit developed where a high dose was used. Radiotherapy has high local control rates and few complications. The local control and complication rates compare favourably to surgery.

  11. Intellectual disability in young people in custody in New South Wales, Australia - prevalence and markers.

    Science.gov (United States)

    Haysom, L; Indig, D; Moore, E; Gaskin, C

    2014-11-01

    Intellectual disability (ID) is known to be more common in incarcerated groups, especially incarcerated youth. Aboriginal young people have higher rates of ID, and make up half of all youth in juvenile custody in New South Wales (NSW), Australia. We aimed to describe the prevalence of possible ID and borderline intellectual functioning (BIF) in young people in NSW custody, and to describe the association between possible ID and Aboriginality after adjusting for the inequalities in social disadvantage. Baseline study of all youth in NSW Custodial Centres between August and October 2009, with 18-month follow-up. Using Wechsler Intelligence Scale for Children - Fourth Edition (WISC-IV) and Wechsler Adult Intelligence Scale - Fourth Edition (WAIS-IV) cognitive assessments, possible ID was defined as Extremely Low Intellectual Quotient range (Full Scale Intellectual Quotient, FSIQ intellectual functioning (by IQ assessment), and 14% had an IQ in the extremely low range (FSIQ intellectual impairment of those incarcerated from a young age. Aboriginal young people with psychosis are also at high risk of cognitive impairments that might indicate a possible co-morbid ID, and these patients should be diverted at court into community assessment services, rather than incarcerated. These results highlight a need for better and earlier identification of young people (particularly Aboriginal youth) at risk of ID and other co-morbidities in the juvenile justice system. © 2014 MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd.

  12. “Unothering” Wales. Domestication as a tourist marketing strategy

    Directory of Open Access Journals (Sweden)

    José Igor Prieto Arranz

    2004-01-01

    Full Text Available Los turistas que visitan el País de Gales son mayoritariamente británicos y su organización nacional de turismo, la Wales Tourist Board, aunque ciertamente está intentando aumentar su cuota de visitantes extranjeros, presta especial atención a aquellos materiales promocionales destinados a una audiencia nacional británica. Dichos materiales, que han sido distinguidos con varios premios en el sector, serán el objeto del presente trabajo, que resalta en especial sus dos características principales: por una parte, su naturaleza intertextual “empotrada”; y por otra, la domesticación de todo lo que entiende por típicamente galés. Como resultado, Gales se acaba convirtiendo en una versión “agradablemente diferente” e incluso perfeccionada de Inglaterra, un claro indicador de que a quien se tiene en mente principalmente es al potencial turista inglés

  13. The solar photovoltaic feed-in tariff scheme in New South Wales, Australia

    International Nuclear Information System (INIS)

    Martin, Nigel; Rice, John

    2013-01-01

    Solar Photovoltaic (PV) electricity systems are part of Australia's energy supply matrix. In the case of New South Wales (NSW), the state government has had to deal with a complex policy problem. In order to play its role in the federal Small-scale Renewable Energy Scheme, the NSW government initiated the 7 year Solar Bonus Scheme in 2010. However, in attempting to maximise community investment in small-scale solar PV systems, it relied on faulty financial modelling that applied a generous Feed-in Tariff (FiT) and underestimated the level of investor participation and installed capacity. Consequently, the scheme has resulted in very high public costs that will require policy changes that bring investors and energy retailers into conflict, and unpopular electricity retail price adjustments. This paper uses a structured case and stakeholder analysis to critically analyse the FiT policy, while also highlighting important lessons for policymakers engaging in FiT design. - highlights: • Describes the design of a feed-in tariff policy for solar PV electricity exports. • Exposes a A$1 billion payment overrun and weaknesses in policy controls. • Identifies policy design flaws and opportunities to improve future tariff designs. • Discusses the importance of developing nationally integrated feed-in tariff policies

  14. A systematic analysis of misleading evidence in unsafe rulings in England and Wales.

    Science.gov (United States)

    Smit, Nadine M; Morgan, Ruth M; Lagnado, David A

    2018-03-01

    Evidence has the potential to be misleading if its value when expressing beliefs in hypotheses is not fully understood or presented. Although the knowledge base to understand uncertainties is growing, a challenge remains to prioritise research and to continuously assess the magnitude and consequences of misleading evidence in criminal cases. This study used a systematic content analysis to identify misleading evidence, drawing information from case transcripts of rulings argued unsafe by the Court of Appeal of England and Wales. In the 7-year study period, 218 applications were successful on appeal, containing 235 cases of misleading evidence. The majority (76%) of successful appeals were based upon the same materials available in the original trial, rather than the presentation of new relevant information. Witness (39%), forensic (32%), and character evidence (19%) were the most commonly observed evidence types, with the validity of witnesses (26%), probative value of forensic evidence (12%), and relevance of character evidence (10%) being the most prevalent combinations of identified issues. Additionally, the majority (66%) of misleading evidence types relate to their interpretation at activity level. The findings suggest that many of these misleading aspects could have been prevented by providing more transparency in the relationship between evidence and hypotheses. Generally, the results contribute to gaining a more complete picture of the role of misleading evidence in the criminal justice system. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  15. Owners' insights into private practice dentistry in New South Wales and the Australian Capital Territory.

    Science.gov (United States)

    Fischer, J E; Marchant, T

    2010-12-01

    The aim of this study was to investigate aspects of practice ownership including debt on graduation, the time period between graduation and acquiring practice ownership and small business skills. A mail survey of 400 dentists with practice ownership, in New South Wales (NSW) and the Australian Capital Territory (ACT), addressed demographics, setting up practice, technology and business management. Most respondents were male and nearly half had 20 years of practice ownership. Dentists agreed with the need to be taught small business management skills. Average debt on graduation was AUD$18 000 and the figure was higher for post 1995 graduates. On average, it took five years to acquire some form of practice ownership, but nearly half acquired ownership within three years. Few favoured opening a new practice. Staff were the most frequently nominated contributors to a successful practice, with fees, profit and parking noted least frequently. There was no question that these experienced dentists thought small business skills should be taught to the dental fraternity. Given the significance of staff to a successful practice, dentists may need to learn more about advanced human resource management including professional development and performance management. © 2010 Australian Dental Association.

  16. Energy futures, state planning policies and coal mine contests in rural New South Wales

    International Nuclear Information System (INIS)

    Connor, Linda H.

    2016-01-01

    The United Nations 2015 Climate Change Conference established a framework for keeping global temperature increase “well below” two degrees Celsius through commitments by the parties to significant reductions in greenhouse gas emissions. The agreement has implications for the energy policies of all countries, not least major coal exporters like Australia. By contrast, the government's 2015 Energy White Paper lays out the vision for the country's future as a “global energy superpower” dominated by the export of fossil fuels for decades to come. Legislative frameworks around planning, land use, mining, heritage and environment have moved in synchrony with this agenda. Rural landowners in the big coal rich geological basins of Australia are directly impacted by current government policies on energy exports and on domestic supply. This article follows the coal value chain to rural communities in New South Wales where new mines are being built, and analyses the politics of land use, natural resources and energy from the vantage point of landowner engagement with government and corporations in the policy, legislative and regulatory domains. The need for more equitable, democratic and precautionary approaches to energy policy, heritage and environmental planning and agricultural land use is highlighted. - Highlights: • Australian energy policies prioritise coal and gas exports to emerging economies. • Rural landholders are marginalised in mining law, environmental protection legislation and planning regulations. • Disputes with companies centre on control of natural resources necessary for agriculture.

  17. Root cause analysis of critical events in neurosurgery, New South Wales.

    Science.gov (United States)

    Perotti, Vanessa; Sheridan, Mark M P

    2015-09-01

    Adverse events reportedly occur in 5% to 10% of health care episodes. Not all adverse events are the result of error; they may arise from systemic faults in the delivery of health care. Catastrophic events are not only physically devastating to patients, but they also attract medical liability and increase health care costs. Root cause analysis (RCA) has become a key tool for health care services to understand those adverse events. This study is a review of all the RCA case reports involving neurosurgical patients in New South Wales between 2008 and 2013. The case reports and data were obtained from the Clinical Excellence Commission database. The data was then categorized by the root causes identified and the recommendations suggested by the RCA committees. Thirty-two case reports were identified in the RCA database. Breaches in policy account for the majority of root causes identified, for example, delays in transfer of patients or wrong-site surgery, which always involved poor adherence to correct patient and site identification procedures. The RCA committees' recommendations included education for staff, and improvements in rostering and procedural guidelines. RCAs have improved the patient safety profile; however, the RCA committees have no power to enforce any recommendation or ensure compliance. A single RCA may provide little learning beyond the unit and staff involved. However, through aggregation of RCA data and dissemination strategies, health care workers can learn from adverse events and prevent future events from occurring. © 2015 Royal Australasian College of Surgeons.

  18. Buckley Sgraffito: a study of a 17th century pottery industry in North Wales, its production techniques and design influences

    Directory of Open Access Journals (Sweden)

    Christine Longworth

    2004-07-01

    Full Text Available The area around Buckley in north Wales has been associated with the production of pottery since the 13th or 14th centuries. Nineteen different pottery sites have been identified, producing a wide range of ceramic wares in the six-hundred year period up to the mid-20th century. In the 17th and 18th centuries, many of the wares produced were of high quality, on a par with Staffordshire wares of the same date. In the early 17th century, the technique of sgraffito decoration spread to north Devon and Somerset from mainland Europe. Buckley is the only known site to produce early sgraffito wares in northern Britain. This article aims to establish the date of the production and range of early sgraffito wares at Buckley and to examine the derivation of the designs and illustrations on the vessels. An illustrated catalogue has been produced and a comparative study made of sgraffito wares elsewhere to place Buckley into a national and international context. The results show that early sgraffito production at Brookhill pottery, Buckley, was between 1640-1720. Of the excavated pieces, 62% were made between 1640-1680, and the number of sherds by vessel number is also greater within that date range. All the vessels are dishes. The form and designs on the remainder of the sherds, dated up to 1720, are no different from those dated to 1640-1680, which suggests a continuous period of production. The most common themes on the pots – tulips, leaves, mottoes, animals and birds – relate very closely to the designs featured on other objects made in the same period such as textiles, wallpaper, furniture and manuscripts. Some of the designs were available in pattern books for particular groups of objects, for example needlework and pastry decoration. There is an interesting sub-group of pieces with animal and bird motifs and mottoes on the rims. It is possible that the influence for these came from a resurgence of interest in the medieval bestiary texts and

  19. Fouling assemblages associated with estuarine artificial reefs in new South Wales, Australia

    Directory of Open Access Journals (Sweden)

    Rob Mckenzie

    2011-01-01

    Full Text Available Previous studies examining the dynamics of succession on artificial reefs have predominantly focussed on fish communities and largely ignored the role of fouling assemblages in explaining the patterns of community structure associated with artificial reefs. The objective of this study was to record the development of epibiotic assemblages on three "design specific" (Reef Ball® estuarine artificial reefs systems located in Lake Macquarie, Botany Bay and St Georges Basin in New South Wales, Australia. Recruitment to the artificial reefs was relatively rapid with the majority of taxa identified over the two-year study period observed within the first year post-deployment. The artificial reefs in Lake Macquarie and St Georges Basin were characterised by low diversity with four and nine taxa recorded respectively in contrast to the sixteen taxa observed on the Botany Bay reefs. Results indicated no significant differences in percentage cover of taxa among reefs in either St Georges Basin or Lake Macquarie. In contrast, comparisons between individual Botany Bay reefs identified significant differences in the percentage cover of species between artificial reefs. Analysis of assemblage structure with reef age indicated discrete patterns among estuaries with an overall reduction in the percentage cover of filamentous turfing algae (FTA identified for all reef systems with an increase in reef age. Variations in environmental and physical conditions (turbidity, water flow, wave action and proximity to naturally occurring reef may have contributed to the observed differences in fouling assemblages between estuaries and between artificial reefs within Botany Bay.Estudos prévios que examinaram a dinâmica de sucessão em recifes artificiais foram focalizados nas comunidades de peixes, e sempre ignoraram o papel exercido pelos organismos incrustantes sobre a estruturação das comunidades associadas aos recifes artificiais. O presente estudo tem por objetivo

  20. Fluvial Responses to Holocene sea Level Variations Along the Macdonald River, New South Wales, Australia

    Science.gov (United States)

    Rustomji, P.; Chappell, J.; Olley, J.

    2003-12-01

    The Macdonald River drains the rugged eastern flanks of Australia's Great Dividing Range. It has a catchment area of 2000km2, restricted alluvial lowlands confined by bedrock interfluves and flows into the Hawkesbury River, a larger estuarine valley. The Macdonald valley is presently tidal for 14km from the Hawkesbury. At about 8000 year before present (BP), rising sea level invaded the Macdonald Valley for at least 35km upstream of the Hawkesbury River. Rapid aggradation occurred between 8000 and 6000 years BP and a sand bed river was established in the Macdonald Valley, its mouth prograding rapidly towards the Hawkesbury. Little is known about the character of the sand bed river during the +2 meter sea level highstand occurring between 5000 and 4000 BP. However, from 3000 to 1500 BP when sea level was consistently at +1 to +1.5m, major floodplain and levee-like structures, now virtually inactive, were established. The bed is inferred to have been elevated above its present day level and consequently intersected mean sea level (MSL) downstream of its present location. This is consistent with reported sea levels at +1 to +2m above present levels for the New South Wales coast at this time. From 1500 years BP, local sea level fell rapidly to its present level. Aggradation of the levee crests ceased and sedimentation along the valley became restricted to aggradation of an inset floodplain, within the pre-1500 BP deposits. The channel contracted and the sandy river bed incised. An equivalent and synchronous change in sedimentation style is observed along the Tuross River 400km south of the Macdonald, lending support to sea level variations being the factor driving this change. By 1850 AD, the bed dipped below MSL about 10km upstream of its inferred position prior to 1500 years BP. A series of large floods between 1949 and 1955 eroded significant volumes of sandy sediment from the Holocene deposits. The channel bed widened from between 25 and 50m width to ˜100m along

  1. CANDU market prospects

    International Nuclear Information System (INIS)

    Kakaria, B.K.

    1994-01-01

    This 1994 survey of prospective markets for CANDU reactors discusses prospects in Turkey, Thailand, the Philippines, Korea, Indonesia, China and Egypt, and other opportunities, such as in fuel cycles and nuclear safety. It was concluded that foreign partners would be needed to help with financing

  2. Sharpening Intertemporal Prospect Theory

    OpenAIRE

    Pushpa, Rathie; Carlos, Radavelli; Sergio, Da Silva

    2006-01-01

    Prospect theory [4] of risky choices has been extended to encompass intertemporal choices [6]. Presentation of intertemporal prospect theory suffers from minor mistakes, however [2]. To clarify the theory we restate it and show further mistakes in current presentations ([6], [2]) of value and discount functions.

  3. Implementing change: staff experiences of changes to prison mental healthcare in England and Wales.

    Science.gov (United States)

    Caulfield, Laura S; Twort, Hannah

    2012-01-01

    Stemming from substantial criticism during the late twentieth and early twenty-first century, the UK government and HM Prison Service developed a number of policies and protocols aimed at improving the state of prison mental healthcare. While it is difficult to fault the purpose of the government's intentions, criticism has continued relating to problems with the implementation of government led change within the prison system. Existing research leads people to question whether policies are being implemented as intended; and if not, why not? The only clear way to answer these questions is to ask those involved in the actual implementation of these recommendations within the prison service. This paper aims to answer these questions. This paper documents findings from a national survey of senior mental healthcare staff working in prisons in England and Wales. Staff were surveyed about their views on the implementation of recommendations from recent key government documents, their perceptions of prison mental healthcare versus community mental healthcare, and their views on the relationship between HM Prison Service and the National Health Service. While many staff report improvements in prison mental healthcare, many have struggled with the implementation of new ways of working and the findings here suggest there is still some way to go towards providing offenders in prison with effective and appropriate care. Where effective ways of implementing change were identified, these are discussed. Listening to the experiences of the staff involved in prison healthcare has helped identify where implementation of changes could be improved and thus highlights where support might best be targeted in future.

  4. Epidemiology of parainfluenza infection in England and Wales, 1998-2013: any evidence of change?

    Science.gov (United States)

    Zhao, H; Harris, R J; Ellis, J; Donati, M; Pebody, R G

    2017-04-01

    Human parainfluenza virus (HPIV) infections are one of the commonest causes of upper and lower respiratory tract infections. In order to determine if there have been any recent changes in HPIV epidemiology in England and Wales, laboratory surveillance data between 1998 and 2013 were analysed. The UK national laboratory surveillance database, LabBase, and the newly established laboratory-based virological surveillance system, the Respiratory DataMart System (RDMS), were used. Descriptive analysis was performed to examine the distribution of cases by year, age, sex and serotype, and to examine the overall temporal trend using the χ 2 test. A random-effects model was also employed to model the number of cases. Sixty-eight per cent of all HPIV detections were due to HPIV type 3 (HPIV-3). HPIV-3 infections were detected all year round but peaked annually between March and June. HPIV-1 and HPIV-2 circulated at lower levels accounting for 20% and 8%, respectively, peaking during the last quarter of the year with a biennial cycle. HPIV-4 was detected in smaller numbers, accounting for only 4% and also mainly observed in the last quarter of the year. However, in recent years, HPIV-4 detection has been reported much more commonly with an increase from 0% in 1998 to 3·7% in 2013. Although an overall higher proportion of HPIV infection was reported in infants (43·0%), a long-term decreasing trend in proportion in infants was observed. An increase was also observed in older age groups. Continuous surveillance will be important in tracking any future changes.

  5. Management of paediatric splenic injury in the New South Wales trauma system.

    Science.gov (United States)

    Adams, Susan E; Holland, Andrew; Brown, Julie

    2017-01-01

    Since the 1980's, paediatric surgeons have increasingly managed blunt splenic injury (BSI) in children non-operatively. However, studies in North America have shown higher operation rates in non-paediatric centres and by adult surgeons. This association has not been examined elsewhere. To investigate the management of BSI in New South Wales (NSW) children, to determine the patient and hospital factors related to the odds of operation. Secondarily, to investigate whether the likelihood of operation varied by year. Children age 0-16 admitted to a NSW hospital between July 2000 and December 2011 with a diagnosis of BSI were identified in the NSW Admitted Patient Data Collection, and linked to deaths data from Registry of Births Deaths and Marriages, and Bureau of Statistics. The operation rate was calculated and compared between different hospital types. Univariable analysis was used to determine patient and hospital factors associated with operative management. The difference in the odds of operation between the oldest data (July 2000-December 2005) and most recent (January 2006-December 2011) was also examined. Multivariable logistic regression with stepwise elimination was then performed to determine likelihood of operative management according to hospital category and era, adjusting for potential confounders. 955 cases were identified, with 101(10.6%) managed operatively. On multivariable analysis, factors associated with operation included age (OR 1.11, 95% CI 1.01-1.18, psplenic disruption (OR 3.10, 95% CI 1.61-6.19, ptrauma centre remained significantly associated with operation, whether it be metropolitan adult trauma centre (OR 4.22 95% CI 1.70-10.52, ptrauma centre (OR 3.72 95% CI 1.83-7.83, ptrauma system is required. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Knowledge of and attitudes to sports drinks of adolescents living in South Wales, UK.

    Science.gov (United States)

    Fairchild, R M; Broughton, D; Morgan, M Z

    2017-06-23

    Background The UK sports drinks market has a turnover in excess of £200 million. Adolescents consume 15.6% of total energy as free sugars, much higher than the recommended 5%. Sugar sweetened beverages, including sports drinks, account for 30% of total free sugar intake for those aged 11-18 years.Objective To investigate children's knowledge and attitudes surrounding sports drinks.Method One hundred and eighty-three self-complete questionnaires were distributed to four schools in South Wales. Children aged 12-14 were recruited to take part. Questions focussed on knowledge of who sports drinks are aimed at; the role of sports drinks in physical activity; and the possible detrimental effects to oral health. Recognition of brand logo and sports ambassadors and the relationship of knowledge to respondents' consumption of sports drinks were assessed.Results There was an 87% (160) response rate and 89.4% (143) claimed to drink sports drinks. 45.9% thought that sports drinks were aimed at everyone; approximately a third (50) viewed teenagers as the target group. Over two thirds recognised the brand logos, yet less than a third could identify brand ambassadors. About half were aware that dental erosion may result from consumption and approximately two thirds knew that they were linked to dental caries and energy provision. Despite this the majority claimed to drink them. As previously reported most of those drinking sports drinks did so because of the taste.Conclusion Whilst most of the respondents had some understanding of the detrimental effects on health the majority of them were drinking them regularly despite this knowledge. Work is therefore needed at a macro level, with soft drink manufacturers, to consider marketing and reformulation of products for adolescent consumers who appear to enjoy them.

  7. Review of laboratory submissions from New World camelids in England and Wales (2000-2011).

    Science.gov (United States)

    Twomey, D F; Wu, G; Nicholson, R; Watson, E N; Foster, A P

    2014-04-01

    Sample submissions to the Animal Health and Veterinary Laboratories Agency's (AHVLA's) diagnostic laboratory network in England and Wales were reviewed for diseases affecting New World camelids (NWCs). In the years 2000-2011, 6757 submissions were analysed, including 5154/6757 (76.3%) for diagnosing a disease problem and 1603/6757 (23.7%) for monitoring (no clinical disease). Wasting (weight loss, ill-thrift) was the most commonly reported clinical sign across all age groups. A diagnosis was reached for 1765/5154 (34.2%) diagnostic submissions. The proportion of submissions with diagnoses was higher for carcasses than non-carcass samples and multiple diagnoses were more likely to be reached from carcasses. Parasitic diseases were collectively the most common problem, including parasitic gastroenteritis (319/1765, 18.2%), coccidiosis (187/1765, 10.6%), fascioliasis (151/1765, 8.6%), ectoparasitic infestations (86/1765, 4.9%) and cryptosporidiosis (24/1765, 1.4%). The most frequently diagnosed non-parasitic problems included nutritional diseases (182/1765, 10.3%), septicaemia (104/1765, 5.9%, including 45 cases of colisepticaemia), gastric ulceration (79/1765, 4.5%), tumours/neoplastic diseases (65/1765, 3.7%), tuberculosis (57/1765, 3.2%), clostridial diseases (44/1765, 2.5%), congenital anomalies (41/1765, 2.3%), peritonitis (39/1765, 2.2%) and Johne's disease (20/1765, 1.1%). Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

  8. Health behaviour and the school environment in New South Wales, Australia.

    Science.gov (United States)

    McLellan, L; Rissel, C; Donnelly, N; Bauman, A

    1999-09-01

    The relationship between the school environment and health has infrequently been examined. This study sought to examine the association between school students' perceptions of their school environment, teachers' and peers' support and their health behaviours. A cross sectional descriptive survey by supervised self-administration was conducted in 1996 based on the international WHO collaborative survey of school children's health and lifestyle (the HBSC Study) and extended in an Australian setting. Randomly sampled primary and secondary schools from Catholic, Independent and Government education sectors throughout New South Wales (NSW), Australia, were invited to participate. The final sample included 3918 school students attending Year 6 (primary school), Year 8 and Year 10 (high school) from 115 schools. The main outcome measures were self-reported health status and 7 health behaviours (tobacco use, alcohol use, physical activity, dental hygiene, nutritional intake, seat belt and bicycle helmet use). Independent variables included student perceptions of the school environment, perceptions of teachers' and peers' support. Girls, Year 6 students and students who have less than $19 a week to spend were significantly more likely to have positive perceptions towards their school environment, teacher(s) and peers. Students who had positive perceptions regarding their school environment and perceived their teachers as supportive were significantly more likely to engage in health promoting behaviours adjusting for age, sex and average weekly pocket money. A supportive peer environment was not associated with positive health behaviour. Health promotion practitioners need to consider the impact of the school environment on health behaviours of school students. In particular, practitioners should consider intervention models that improve the school environment as a key strategy within a health promoting school.

  9. Zircon dating of Devonian-Carboniferous rocks from the Bombala area, New South Wales

    International Nuclear Information System (INIS)

    Sircombe, K.N.; McQueen, K.G.

    2000-01-01

    Zircons from two igneous and two sedimentary units in the Bombala area of southeastern New South Wales have been examined by the sensitive high resolution ion microprobe (SHRIMP) to establish a time frame in which to interpret these rocks. Previous studies have correlated these rocks with Late Devonian units of the south coast, solely upon the basis of stratigraphy and lithology as palaeontological evidence was absent. The two igneous units are the Hospital Porphyry and Paradise Porphyry occurring beneath the sedimentary units. Both give a Frasnian age that can be correlated with the Boyd Volcanic Complex. The sedimentary samples are from the basal and upper sections of the Rosemeath Formation, a fluvial 'redbed' consisting of conglomerate, coarse sandstone, and associated red siltstone and mudstone. Detrital zircons from the basal conglomeratic section at Kilbrechin indicate a dominant provenance from local Silurian granites and volcanics and a maximum depositional age that can be correlated with the Frasnian-Famennian Merrimbula Group. However, detrital zircons from the upper coarse sandstone section of the Rosemeath Formation at Endeavour Lookout challenge the positive correlation trend with a lack of Silurian-age grains and a presence of grains ranging from Late Devonian to Early Carboniferous in age. These results imply either that the south coast correlation is not valid for the upper sequences, or that the Merrimbula Group sequences also extend upward into the Carboniferous. The general coarseness of the Rosemeath Formation also suggests a relatively local provenance. No Early Carboniferous source is known in the immediate vicinity suggesting that Early Carboniferous igneous activity in this region of the Lachlan Orogen may have been more extensive than is currently realised. Copyright (1999) Geological Society of Australia

  10. The determinants of transitions into sheltered accommodation in later life in England and Wales

    Science.gov (United States)

    Vlachantoni, Athina; Maslovskaya, Olga; Evandrou, Maria; Falkingham, Jane

    2016-01-01

    Background Population ageing is a global challenge and understanding the dynamics of living arrangements in later life and their implications for the design of appropriate housing and long-term care is a critical policy issue. Existing research has focused on the study of transitions into residential care in the UK. This paper investigates transitions into sheltered accommodation among older people in England and Wales between 1993 and 2008. Methods The study uses longitudinal data constructed from pooled observations across waves 2–18 of the British Household Panel Survey (BHPS) data, focusing on individuals aged 65 and over who lived in private housing at baseline and who were observed for two consecutive time points. A discrete-time logistic regression model was used to examine the association of transitioning into sheltered accommodation with a range of demographic, health and socioeconomic predictors. Results Demographic (age, region), socioeconomic factors (housing tenure, having a washing machine) and contact with health professionals (number of visits to the general practitioner, start in use of health visitor) were significant determinants of an older person's move into sheltered accommodation. Conclusions Transitions into sheltered accommodation are associated with a range of demographic and socioeconomic characteristics as well as service use but not with health. Such results indicate that this type of housing option may be accessible by individuals with relatively good health, but may be limited to those who are referred by gatekeepers. Policymakers could consider making such housing option available to everyone, as well as providing incentives for building lifecourse-sensitive housing in the future. PMID:26896519

  11. Fauna of four streams in the Black Mountain District of South Wales

    Energy Technology Data Exchange (ETDEWEB)

    Jones, J R.E.

    1948-01-01

    This paper is a general study of four torrential streams in the 'Black Mountain' district of South Wales. Fauna collections were made at seven collecting stations, between altitudes of 1550 and 400 ft. Observations were made on the chemical nature of the water, current speed and temperature. The fauna taken as a whole is rich, including about 151 species. Of the four streams, the one flowing north has the richest fauna, which includes about 130 species in which all the usual aquatic animal groups except the hirudinea are represented. This may be attributed to its equable temperature, abundant and uniform flow, variable gradient, adequate macroflora, and alkaline-neutral moderately calcareous water. The streams flowing south all have very soft, acid water; their stream-beds are more uniform in gradient, they are extremely variable in flow, have a more scanty macroflora, and on sunny summer days the water temperature is high, little below the shade temperature. All have a much poorer fauna than the north-flowing stream. One has a pH of 6.0-6.8, the fauna includes about 65 species, the usual insect groups are well represented but only 9 species other than insects occur. The second has a pH of 6.0 at low level to 4.4 in full flood; here 57 species were found, again mainly insects, and the ephemorophtera are very poorly represented. The third southern stream is generally even more acid, pH 5.8-4.2. Its fauna includes 55 species of which 24 are beetles, plecoptera are very poorly represented and ephemeroptera absent.

  12. Fauna of four streams in the Black Mountain District of South Wales

    Energy Technology Data Exchange (ETDEWEB)

    Jones, J.R.E.

    1948-01-01

    This paper is a general study of four torrential streams in the 'Black Mountain' district of South Wales. Fauna collections were made at seven collecting stations, between altitudes of 1550 and 400 ft. Observations were made on the chemical nature of the water, current speed and temperature. The fauna taken as a whole is rich, including about 151 species. Of the four streams, the one flowing north has the richest fauna, which includes about 130 species in which all the usual aquatic animal groups except the hirudinea are represented. This may be attributed to its equable temperature, abundant and uniform flow, variable gradient, adequate macroflora, and alkaline-neutral moderately calcareous water. The streams flowing south all have very soft, acid water; their stream-beds are more uniform in gradient, they are extremely variable in flow, have a more scanty macroflora, and on sunny summer days the water temperature is high, little below the shade temperature. All have a much poorer fauna than the north-flowing stream. One has a pH of 6.0-6.8, the fauna includes about 65 species, the usual insect groups are well represented but only 9 species other than insects occur. The second has a pH of 6.0 at low level to 4.4 in full flood; here 57 species were found, again mainly insects, and the ephemorophtera are very poorly represented. The third southern stream is generally even more acid, pH 5.8-4.2. Its fauna includes 55 species of which 24 are beetles, plecoptera are very poorly represented and ephemeroptera absent.

  13. Is bigger better? An empirical analysis of waste management in New South Wales

    International Nuclear Information System (INIS)

    Carvalho, Pedro; Marques, Rui Cunha; Dollery, Brian

    2015-01-01

    Highlights: • We search for the most efficient cost structure for NSW household waste services. • We found that larger services are no longer efficient. • We found an optimal size for the range 12,000–20,000 inhabitants. • We found significant economies of output density for household waste collection. • We found economies of scope in joint provision of unsorted and recycling services. - Abstract: Across the world, rising demand for municipal solid waste services has seen an ongoing increase in the costs of providing these services. Moreover, municipal waste services have typically been provided through natural or legal monopolies, where few incentives exist to reduce costs. It is thus vital to examine empirically the cost structure of these services in order to develop effective public policies which can make these services more cost efficient. Accordingly, this paper considers economies of size and economies of output density in the municipal waste collection sector in the New South Wales (NSW) local government system in an effort to identify the optimal size of utilities from the perspective of cost efficiency. Our results show that – as presently constituted – NSW municipal waste services are not efficient in terms of costs, thereby demonstrating that ‘bigger is not better.’ The optimal size of waste utilities is estimated to fall in the range 12,000–20,000 inhabitants. However, significant economies of output density for unsorted (residual) municipal waste collection and recycling waste collection were found, which means it is advantageous to increase the amount of waste collected, but maintaining constant the number of customers and the intervention area

  14. Age at marriage and the risk of divorce in England and Wales

    Directory of Open Access Journals (Sweden)

    Richard Lampard

    2013-07-01

    Full Text Available BACKGROUND A well-documented association exists between age at marriage and the risk of divorce. However, substantial gaps in our knowledge and understanding of ist origins, nature, and implications still exist. OBJECTIVE This article documents the relationship between women's ages at first marriage and marriage cohort divorce rates, assessing the importance of relative ages at marriage (based on rankings within marriage cohorts and of absolute, chronological ages at marriage, and evaluating the contribution of changes in the age at marriage distribution to observed divorce rates. METHODS Direct standardisation and logistic regression analyses are applied to published marriage and divorce data for the 1974-1994 marriage cohorts in England and Wales. RESULTS Changing ages at marriage appear to have constrained the rise in divorce across the cohorts examined. However, the results suggest that much of the impact of age at marriage is linked to relative ages, reducing the extent of this 'braking' effect. It also appears that a positive effect of relative age at marriage on the risk of divorce for later marriages is outweighed by the negative effect of absolute age at marriage at higher ages. CONCLUSIONS Both explanations relating to 'maturity' and explanations focusing on 'selection' or 'marriage markets' appear of relevance to the association between age at marriage and divorce. COMMENTS The data source provides over five million cases; however, it does not provide any scope to control for cohabitation, education, etc., and the analyses are restricted to divorces within about ten years of marriage. Further, related studies would be useful.

  15. Healthy food and beverages in senior community football club canteens in New South Wales, Australia.

    Science.gov (United States)

    Young, Kylie; Kennedy, Vanessa; Kingsland, Melanie; Sawyer, Amy; Rowland, Bosco; Wiggers, John; Wolfenden, Luke

    2012-08-01

    Little is known of the extent to which senior sports clubs support the consumption of healthy food and beverages. This study of senior community football clubs aimed to describe: i) the food and beverages available in club canteens; ii) the perceived acceptability of club representatives (e.g. club president or secretary) to selling healthy food and beverages in club canteens; iii) the perceived barriers of club representatives to providing healthy food and beverage options in their club canteen; iv) the associations between the availability of healthy options in canteens, perceived barriers to healthy food and drink availability, and club characteristics; and (v) the food and beverages usually purchased from canteens by club members. The study involved 70 senior community football clubs (Australian Rules Football, Soccer, Rugby League and Rugby Union) across New South Wales, Australia. Club representatives and club members took part in cross-sectional telephone surveys. The most frequently available items at club canteens were regular soft drinks and potato chips or other salty snacks (available at 99% of clubs). Approximately two-thirds (66%) of club representatives agreed or strongly agreed that clubs should provide a greater variety of healthy food options. Perishability and lack of demand were the most frequently cited barriers to healthy food provision. Healthy food options were more available at AFL clubs compared with other football codes. Overall, 6% of club members reported purchasing a healthy food option. Senior community football clubs primarily stock and sell unhealthy food and beverage items. There is support within clubs for providing more healthy options; however, clubs face a number of barriers to the inclusion of healthy foods in club canteens.

  16. Sporotrichosis (Sporothrix schenckii infection) in the New South Wales mid-north coast, 2000-2010.

    Science.gov (United States)

    Sivagnanam, Shobini; Bannan, Aiveen M; Chen, Sharon C-A; Ralph, Anna P

    2012-05-21

    To determine the geographical, epidemiological and clinical features of sporotrichosis (a cutaneous fungal infection caused by Sporothrix schenckii) in the New South Wales mid-north coast. We undertook a retrospective case review of S. schenckii infections that occurred during the period 2000-2010. Microbiology laboratory staff and medical practitioners in the NSW mid-north coast were contacted to identify cases through database searches and clinical data collection. Thirty-one cases of S. schenckii infection were identified. Twenty-one occurred in males, the mean age of patients was 59 years, and all cases with data available involved cutaneous disease affecting the limbs (multiple lesions in 18 of 20 cases). Despite an impression of temporal clustering (eight cases in 1 year), this was not statistically significant (P = 0.3). Most cases occurred in months with higher rainfall (13 of 14 cases with data available). Inoculating events included injuries in gardens, in bushland and on farms, and possible bites. Symptom duration before correct diagnosis ranged from 4 to 30 weeks (median, 8 weeks; data available for 15 cases), unnecessary antibacterial therapy was common (13 of 19 cases with data available), and morbidity occurred in the form of recurrence (three cases) and mild itraconazole-induced hepatotoxicity (two cases). In all cases with recorded treatment details, the patients received itraconazole, and the median duration of itraconazole treatment was 24 weeks. These data highlight that health providers on the NSW mid-north coast should consider sporotrichosis when patients present with characteristic lesions after an inoculating injury sustained from or contaminated by decaying vegetation. The risk may be higher in older people and in wetter months. Fungal culture to confirm the diagnosis needs to be specifically requested. In contrast to outbreaks reported from other states, the epidemiological pattern in NSW appears most consistent with sporadic occurrence

  17. Speaking Too Soon: The Sabotage of Bail Reform in New South Wales

    Directory of Open Access Journals (Sweden)

    Julia Quilter

    2014-10-01

    Full Text Available Within just over one month of coming into operation in May 2014, the new Bail Act 2013 (NSW, a product of long-term law reform consideration, was reviewed and then amended after talk-back radio ‘shock jock’ and tabloid newspaper outcry over three cases. This article examines the media triggers, the main arguments of the review conducted by former New South Wales (NSW Attorney General John Hatzistergos, and the amendments, with our analysis of the judicial interpretation of the Act thus far providing relevant background. We argue that the amendments are premature, unnecessary, create complexity and confusion, and, quite possibly, will have unintended consequences: in short, they are a mess. The whole process of reversal is an example of law and order politics driven by the shock jocks and tabloid media, the views of which, are based on fundamental misconceptions of the purpose of bail and its place in the criminal process, resulting in a conflation of accusation, guilt and punishment. Other consequences of the review and amendments process recognised in this article include the denigration of judicial expertise and lack of concern with evidence and process; the disproportionate influence of the shock jocks, tabloids and Police Association of NSW on policy formation; the practice of using retired politicians to produce ‘quick fix’ reviews; and the political failure to understand and defend fundamental legal principles that benefit us all and are central to the maintenance of a democratic society and the rule of law. The article concludes with some discussion of ways in which media and political debate might be conducted to produce more balanced outcomes.

  18. Legislating thresholds for drug trafficking: a policy development case study from New South Wales, Australia.

    Science.gov (United States)

    Hughes, Caitlin Elizabeth; Ritter, Alison; Cowdery, Nicholas

    2014-09-01

    Legal thresholds are used in many parts of the world to define the quantity of illicit drugs over which possession is deemed "trafficking" as opposed to "possession for personal use". There is limited knowledge about why or how such laws were developed. In this study we analyse the policy processes underpinning the introduction and expansion of the drug trafficking legal threshold system in New South Wales (NSW), Australia. A critical legal and historical analysis was undertaken sourcing data from legislation, Parliamentary Hansard debates, government inquiries, police reports and research. A timeline of policy developments was constructed from 1970 until 2013 outlining key steps including threshold introduction (1970), expansion (1985), and wholesale revision (1988). We then critically analysed the drivers of each step and the roles played by formal policy actors, public opinion, research/data and the drug trafficking problem. We find evidence that while justified as a necessary tool for effective law enforcement of drug trafficking, their introduction largely preceded overt police calls for reform or actual increases in drug trafficking. Moreover, while the expansion from one to four thresholds had the intent of differentiating small from large scale traffickers, the quantities employed were based on government assumptions which led to "manifest problems" and the revision in 1988 of over 100 different quantities. Despite the revisions, there has remained no further formal review and new quantities for "legal highs" continue to be added based on assumption and an uncertain evidence-base. The development of legal thresholds for drug trafficking in NSW has been arbitrary and messy. That the arbitrariness persists from 1970 until the present day makes it hard to conclude the thresholds have been well designed. Our narrative provides a platform for future policy reform. Copyright © 2014 Elsevier B.V. All rights reserved.

  19. Skin conditions are the commonest new reason people present to general practitioners in England and Wales.

    Science.gov (United States)

    Schofield, J K; Fleming, D; Grindlay, D; Williams, H

    2011-11-01

    Knowledge of the prevalence and incidence of skin conditions is a prerequisite for designing clinical services and providing appropriate training for primary health care professionals. In the U.K. the general practitioner and practice nurse are the first point of medical contact for persons with skin conditions. We aimed to obtain contemporary data in age-, gender- and diagnosis-specific detail on persons presenting to primary care with skin problems. Comparisons were made with similar data for other major disease groups and with similar data from other recent years. We used surveillance data collected in the Weekly Returns Service (WRS) of the Royal College of General Practitioners during 2006 and trend data for subsequent years. The WRS sentinel practices monitor all consultations by clinical diagnosis in a representative population of 950,000 in England and Wales. For conditions included in chapter XII of the International Classification of Diseases Ninth Revision (ICD9), 15% of the population consulted; a further 9% presented with skin problems classified elsewhere in the ICD9, making a total of 24%. There was no evidence of increasing or decreasing trend since 2006. Skin infections were the commonest diagnostic group, while 20% of children skin disorders (including diagnoses outside chapter XII) exceeded incidences for all other major disease groupings. Compared with other major disease groups, skin conditions are the most frequent reason for consultation in general practice. This result emphasizes the need for appropriate education and training for all medical students and particularly for continuing education in dermatology for all primary health care professionals. © 2011 The Authors. BJD © 2011 British Association of Dermatologists.

  20. A national-scale assessment of micro-organic contaminants in groundwater of England and Wales.

    Science.gov (United States)

    Manamsa, Katya; Crane, Emily; Stuart, Marianne; Talbot, John; Lapworth, Dan; Hart, Alwyn

    2016-10-15

    A large variety of micro-organic (MO) compounds is used in huge quantities for a range of purposes (e.g. manufacturing, food production, healthcare) and is now being frequently detected in the aquatic environment. Interest in the occurrence of MO contaminants in the terrestrial and aquatic environments continues to grow, as well as in their environmental fate and potential toxicity. However, the contamination of groundwater resources by MOs has a limited evidence base compared to other freshwater resources. Of particular concern are newly 'emerging contaminants' such as pharmaceuticals and lifestyle compounds, particularly those with potential endocrine disrupting properties. While groundwater often has a high degree of protection from pollution due to physical, chemical and biological attenuation processes in the subsurface compared to surface aquatic environments, trace concentrations of a large range of compounds are still detected in groundwater and in some cases may persist for decades due to the long residence times of groundwater systems. This study provides the first national-scale assessment of micro-organic compounds in groundwater in England and Wales. A large set of monitoring data was analysed to determine the relative occurrence and detected concentrations of different groups of compounds and to determine relationships with land-use, aquifer type and groundwater vulnerability. MOs detected including emerging compounds such as caffeine, DEET, bisphenol A, anti-microbial agents and pharmaceuticals as well as a range of legacy contaminants including chlorinated solvents and THMs, petroleum hydrocarbons, pesticides and other industrial compounds. There are clear differences in MOs between land-use types, particularly for urban-industrial and natural land-use. Temporal trends of MO occurrence are assessed but establishing long-term trends is not yet possible. Copyright © 2016 British Geological Survey, NERC. Published by Elsevier B.V. All rights reserved.

  1. Nutrient intake during peritoneal dialysis at the Prince of Wales Hospital in Hong Kong.

    Science.gov (United States)

    Wang, Angela Yee-Moon; Sea, Mandy Man-Mei; Ng, Kenway; Kwan, Mandy; Lui, Siu-Fai; Woo, Jean

    2007-05-01

    Individuals undergoing peritoneal dialysis are at increased risk of developing cardiac disease and malnutrition. A cross-sectional survey. 249 Chinese continuous ambulatory peritoneal dialysis (CAPD) patients were recruited from the Prince of Wales Hospital in Hong Kong. Another 249 age- and sex-matched controls were recruited from an archive of 1,010 individuals with known food frequency questionnaire (FFQ) data. To compare the dietary intake pattern of CAPD patients with controls and evaluate its association with background cardiac disease. Intake of different nutrients was estimated by using a 7-day FFQ. Intake of all nutrients was lower in CAPD patients than controls, with resulting lower overall energy intake. Nutrient intake was decreased further in CAPD patients with background cardiac disease, which corresponded to worse nutritional status. Controlling for age, male sex, body weight, diabetes mellitus, dialysis therapy duration, residual renal function, peritoneal dialysis urea clearance, and Charlson Comorbidity Index score, background cardiac disease was associated independently with less intake of energy and most macronutrients and micronutrients. However, the association between background cardiac disease and energy and most nutrient intake was decreased or even lost when additional adjustment was made for C-reactive protein and serum albumin levels. An FFQ is limited in that nutrient quantitation is not exact and may be underestimated as a result of underreporting by patients. CAPD patients were compared with a control group without cardiovascular disease ascertainment that did not include subjects with diabetes. Chinese CAPD patients had significantly lower nutrient intake than age- and sex-matched controls. The association between cardiac disease and lower dietary macronutrient and micronutrient intake in CAPD patients was mediated in part through systemic inflammation, which also was associated with more malnutrition. More attention should be

  2. Paragangliomas: presentation and management by radiotherapy at the Prince of Wales Hospital.

    Science.gov (United States)

    Smee, Robert I; Jayasekara, Jayana; Williams, Janet R; Hanna, Claire

    2015-04-01

    Paragangliomas are commonly treated with surgery, while radiotherapy is reserved for those that are inoperable or have relapsed. However, this retrospective study aims to determine whether radiotherapy is a viable initial treatment for paragangliomas. Of 73 tumours researched, 44 were diagnosed and treated from January 1967 to December 2012 at the Radiation Oncology Department at the Prince of Wales Hospital and thus were eligible for analysis. Median follow-up time was 3.5 years with a range of 1 to 40 years. Thirty-four tumours were treated with radiotherapy only, and 10 tumours were treated with both surgical resection and radiotherapy. Local control and cause-specific survival were the primary end points measured. Five-year local control rate for the population of 44 lesions was 89%; it was 100% in the group treated by radiotherapy alone, but only 50% in the group treated by surgery followed by radiotherapy, with radiation used for salvage. The difference in control rates between these two subset groups was found to be statistically significant (P < 0.001). Cause-specific survival rates for this eligible population at 5 and 10 years were 98% and 90%, respectively. After initial radiotherapy, 4 patients had improved cranial nerve function, there was clinical improvement in tinnitus, and one new cranial nerve deficit developed where a high dose was used. Radiotherapy has high local control rates and few complications. The local control and complication rates compare favourably to surgery. © 2014 The Royal Australian and New Zealand College of Radiologists.

  3. Neospora caninum in beef herds in New South Wales, Australia. 2: analysis of risk factors.

    Science.gov (United States)

    Moloney, B J; Heuer, C; Kirkland, P D

    2017-04-01

    To determine the influence of farm-level and animal-level factors on the seroprevalence of antibodies to Neospora caninum and associations between seropositivity and reproductive outcomes. A questionnaire for a cross-sectional survey was posted to the 63 properties with a herd size ≥50 beef breeding cows that had participated in a previous seroprevalence study. Correspondence analysis, which does not appear to have been used previously in any Australian studies of livestock diseases, was used in conjunction with logistic regression to analyse the data. Geographic factors that increased the risk of seropositivity included higher rainfall North Coast location. Herd management factors that increased the risk of seropositivity included the use of Bos indicus genetics, cross-breeding and running several breeds in the one herd. Using fox control measures was found to be protective against infection with N. caninum. The risk of abortion was 12-fold greater in individual animals that were seropositive for N. caninum. Within a herd, the calving rate was 10.4% lower in herds with one or more N. caninum-positive animals (P = 0.03), but the difference in abortion rate was not significant between seropositive and seronegative herds (0.3% higher, P > 0.3). This study confirmed previous observations of increased risks for N. caninum seropositivity with being located in the coastal subtropics, some styles of herd management and canid exposure. In addition, it suggested that cross-breeding and proximity to an urban area may increase the risk, and that having pet dogs may reduce the risk of seropositivity. © 2017 State of New South Wales.

  4. Coroners' records of rural and non-rural cases of youth suicide in New South Wales.

    Science.gov (United States)

    Dudley, M; Kelk, N; Florio, T; Waters, B; Howard, J; Taylor, D

    1998-04-01

    The aim of this study is to compare the frequency of certain putative risk factors for youth suicide in New South Wales (especially use of alcohol, social class, unemployment, and internal migration) in metropolitan and rural settings. A review of 137 files for 10-19-year-old subjects judged by the Coroner to have committed suicide in 1988-1990 was carried out. One hundred and fifteen males and 21 females were identified (one subjects sex was unavailable). The male-female ratio was higher in rural (13.0) areas than non-rural (4.9 chi 2 = 12.14, p Australia, most migrated in a rural direction, and most to rural shires. Unemployment was somewhat more common among rural (38.5%) than non-rural (28.9%) subjects (chi 2 = 0.75, p = 0.39). Eleven of 50 non-rural parents of the deceased, but none of the 11 rural parents, were ranked as being in social classes 2 or 3. Alcohol consumption appeared more common in rural shires (44%) than metropolitan areas (32.9%), but this was not statistically significant. Medical services were less utilised prior to death in rural (15%) than non-rural (25%) areas (chi 2 = 1.69, p = 0.19), and a psychiatric diagnosis was recorded more commonly in non-rural areas. Incomplete coronial file data and relatively small numbers limit this study's conclusions. Male suicides, principally by firearms, predominated in rural areas. Youth firearm access remains highly relevant to rural communities. Possible trends among rural subjects toward rural migration, higher unemployment, lower social class and lower medical attendance may point to resource deprivation among this group; these matters require further investigation.

  5. A survey of imaging services for children in England, Wales and Scotland

    International Nuclear Information System (INIS)

    Mathers, Sandra A.; Anderson, Helen; McDonald, Sheila

    2011-01-01

    Purpose: Children are major users of imaging services but little is known about the provision made for them. The objectives of this survey were to: determine the extent to which children are imaged in primarily adult departments and the nature of procedures performed; establish the availability of child friendly environments and investigate the extent to which children are involved in service development. Methods: An 18 item questionnaire was sent to all hospitals with imaging facilities in the UK. Two versions were produced, one for adult departments and another for children's hospitals. Quantitative data were entered into SPSS-PC. Results: Three hundred and fifty two questionnaires were returned including 17 from the 20 children's hospitals, representing a 70% response rate. Children were imaged in 84% of adult hospitals from which responses were obtained and estimates provided by respondents indicated that more children were imaged in adult than children's hospitals. In 89% of adult hospitals responses indicated that infants were imaged and in two thirds of English hospitals advanced procedures, such as MRI, were available for children. In 47%, 32% and 30% of adult hospitals in England, Wales and Scotland children's requirements were said to be considered when purchasing equipment. In 34%, 11% and 8% of English, Welsh and Scottish adult hospitals some separate provision for children (for example waiting rooms or toilets) was indicated. Overall 32% of adult hospitals (92 of the 95 were in England) reported having a lead radiographer, who specialised in a paediatric imaging. Responses indicated that in 60% of adult hospitals staff attended paediatric training courses. Children's views on hospital services were seldom sought in either the adult or children's hospitals. Conclusions: The survey indicates that the recommendations of the Children's National Service Framework and the Health Care Commission have not been implemented fully in many imaging departments.

  6. Off-site movement of endosulfan from irrigated cotton in New South Wales.

    Science.gov (United States)

    Kennedy, I R; Sánchez-Bayo, F; Kimber, S W; Hugo, L; Ahmad, N

    2001-01-01

    The fate and transport of endosulfan (6,7,8,9,10,10-hexachloro-1,5, 5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide) applied to cotton (Gossypium hirsutum L.) fields were studied throughout three consecutive years on two selected locations in New South Wales (Australia). Rates of dissipation from foliage and soil, volatilization from the field, and transport of residues in irrigation and/or storm runoff waters were measured in order to estimate a total field balance. Dissipation of endosulfan from both foliage and soil is best explained by a two-phase process rather than by a first-order decay. Half-lives of total endosulfan toxic residues (alpha- and beta-endosulfan and the sulfate product) in the first phase were 1.6 d in foliage and 7.1 d in soil, and could be explained by the rapid volatilization of the parent isomers in the first 5 d (up to 70% of endosulfan volatilizes). In the second phase, half-lives were 9.5 d in foliage and 82 d in soil, mostly due to the persistence of the sulfate product. Concentration of endosulfan residues in runoff water varied from 45 to 2.5 microg L(-1) depending on the residue levels present on field soil at the time of the irrigation or storm events. These in turn are related to the total amounts applied, the cotton canopy cover at application, and the time since last spraying. Most of the endosulfan in runoff was found in the water phase (80%), suggesting it was bound to colloidal matter. Total endosulfan residues in runoff for a whole season accounted for no more than 2% of the pesticide applied on-field.

  7. An audit of the laboratory diagnosis of cryptosporidiosis in England and Wales.

    Science.gov (United States)

    Chalmers, Rachel M; Atchison, Christina; Barlow, Katrina; Young, Yvonne; Roche, Anita; Manuel, Rohini

    2015-07-01

    To assess the level of practice consistent with UK national standards for Cryptosporidium testing, an audit was performed of 156 publicly funded clinical microbiology laboratories in England and Wales between August 2013 and April 2014. Responses were received from 85 (54 %) laboratories. First line diagnostic methods used were mainly microscopy with modified Ziehl-Neelsen (mZN) or auramine phenol (AP) staining (68/85, 80 %), enzyme immunoassays (EIAs) (16/85, 19 %) or in-house PCR (1/85, 1 %). The use of EIAs was more widespread than reported previously. Various methods were used for confirmation of positive EIA reactions and laboratories frequently resorted to sending samples to the national reference laboratory for this purpose, indicating that guidance is required for performance monitoring and confirmation of positive reactions. Laboratory positivity rates were related to the diagnostic test used, with highest median rates reported by those using PCR, EIAs or AP microscopy, and the lowest by those using mZN microscopy. One-third of responding laboratories (28/85, 33 %) routinely tested all stools for Cryptosporidium. However, 16 (19 %) laboratories used stool consistency to decide whether to test for this parasite. Other selection criteria included patient age (n = 18; 21 % laboratories), history or clinical details (n = 40; 47 %), duration of hospitalization (n = 18; 21 %) or clinician requests (n = 25; 29 %). To encourage laboratories to test all stools submitted for the investigation of diarrhoeal illness for Cryptosporidium, revision of the guidance in the national standards is under way. This will enable improved assessment of the burden of illness and ability to monitor outbreaks, and measure changes in reported cases.

  8. Longitudinal perspectives on caregiving, employment history and marital status in midlife in England and Wales.

    Science.gov (United States)

    Young, Harriet; Grundy, Emily

    2008-07-01

    In this paper, we examine associations between employment history and marital status and unpaid care provision among those aged 40-59 in England and Wales. We used data from a large nationally representative longitudinal study, the Office for National Statistics Longitudinal Study. Initially based on a sample drawn from the 1971 Census, in 2001 this study included data on 110,464 people aged 40-59 of whom 5% provided 20 or more hours per week of unpaid care. We analysed associations between caregiving of this intensity and current employment, employment history, employment characteristics, marital status, and employment after childbearing. Among men, caregiving was associated with a history of lower levels of employment. The small group of men with a history of least employment were 70% more likely to provide care than those with a history of most employment. Among women, caregiving was associated with a history of non-employment, but there were no differences between those with fully engaged and partially engaged labour market histories. Analyses of a subset of data on women who had a child between 1981 and 1991 showed that those who had returned to full-time paid work by 1991 were over 50% less likely to later become caregivers. Some associations between employment characteristics and propensity to provide 20 or more hours per week of care were also identified. Those in public sector jobs and those previously in employment with a caregiving dimension were 20-30% more likely than other working women to provide unpaid care. These results suggest a continuing gender dimension in care provision which interacts with marital status and employment in gender-specific ways. It also suggests that implementation of strategies to enable those in midlife to combine caregiving and work responsibilities, should they wish to do so, should be an urgent priority.

  9. NATO Summit in Wales: From global megatrends to the new Euro-Atlanticism

    Directory of Open Access Journals (Sweden)

    Vukadinović Lidija Čehulić

    2014-10-01

    Full Text Available Numerous representatives of theories of international relations, security theories or alliance theories have examined the new role of the North Atlantic Alliance or the North Atlantic Treaty Organization (NATO in the post-bipolar world. Parallel with the theoretical examination of goals and tasks, NATO has transformed itself in practice, following the realities of the contemporary global era. In trying to achieve and keep the primacy of the strongest military- political organization, the Alliance has - especially in the Strategic Concept adopted in Lisbon in 2010-set the normative and institutional foundations of its global engagement, fulfilling the military (hard and a wide array of non-military (soft security challenges. This strategy has given rise to "Euro-Atlanticism", as a subsystem of international relations based on strong American-European relations, to fit with the process of regionalization of global politics. However, the 2013-2014 crisis in Ukraine has turned the focus of interest and activities of NATO once again primarily to Europe and it has stressed the importance and necessity of strengthening Euro-Atlantic security and defence ties. The most powerful member of the Alliance, the United States, is again strongly engaged in Europe and Russia, as a kind of successor to the Soviet Union, is once more detected as a major threat to European security. There have been many aspects of theories of international relations that have tried to explain the dynamic of the post-Cold War international community. However, the approach based on neo-realistic assumptions of the role of a security community, collective defence and the use of military force has proved to be dominant. NATO will continue to work on its political dimension as an alliance of the democratic world and the September 2014 Wales Summit will certainly mark the return of NATO to its roots, strengthening its security and military dimensions in the collective defence of Europe

  10. Soil governance in the agricultural landscapes of New South Wales, Australia

    Directory of Open Access Journals (Sweden)

    Ashley A Webb

    2015-03-01

    Full Text Available Soil is a valuable natural resource. In the state of New South Wales, Australia, the governance of soil has evolved since Federation in 1901. Following rapid agricultural development, and in the face of widespread soil degradation, the establishment of the Soil Conservation Service marked a turning point in the management of soil. Throughout the 20th century, advances in knowledge were translated into evolving governance frameworks that were largely reactionary but saw progressive reforms such as water pollution legislation and case studies of catchment-scale land and vegetation management. In the 21st century, significant reforms have embedded sustainable use of agricultural soils within catchment- and landscape-scale legislative and institutional frameworks. What is clear, however, is that a multitude of governance strategies and models are utilised in NSW. No single governance model is applicable to all situations because it is necessary to combine elements of several different mechanisms or instruments to achieve the most desired outcomes. Where an industry, such as the sugar industry, has taken ownership of an issue such as acid sulfate soil management, self-regulation has proven to be extremely effective. In the case of co-managing agricultural soils with other landuses, such as mining, petroleum exploration and urban development, regulation, compliance and enforcement mechanisms have been preferred. Institutional arrangements in the form of independent commissioners have also played a role. At the landscape or total catchment level, it is clear that a mix of mechanisms is required. Fundamental, however, to the successful evolution of soil governance is strategic investment in soil research and development that informs the ongoing productive use of agricultural landscapes while preventing land degradation or adverse environmental effects.

  11. Equity and service innovation: the implementation of a bibliotherapy scheme in Wales.

    Science.gov (United States)

    Porter, Alison; Peconi, Julie; Evans, Angela; Snooks, Helen; Lloyd, Keith; Russell, Ian

    2008-04-01

    Book Prescription Wales (BPW) is a pilot bibiliotherapy scheme launched in July 2005 as a primary care treatment option for people with mild to moderate mental health problems. In an innovative model, patients are prescribed self-help books from a list, to borrow from local libraries. Our objective was to evaluate its implementation, focusing on the issue of equity of service delivery. Data were gathered from Welsh Assembly Government concerning project set-up and borrowing rates. Mailed questionnaires were completed by 21/22 (95.4%) Local Health Boards and 44/64 (68.8%) Community Mental Health Teams. In addition, 327 out of 497 (66%) primary care practices were surveyed by telephone, 20 prescribers took part in in-depth telephone interviews and three focus groups were conducted with library staff. From July 2005-March 2006, books were borrowed 15,236 times. There was a 10-fold variation in borrowing rates across local authorities (1.07 to 10.18 loans/1000 people). The priority which Local Health Board staff reported giving to the scheme varied. Uptake among prescribers was mixed: in 35% of general practices (n = 116) no-one participated. Prescribers reported different ways of using the bibliotherapy scheme. Library staff reported issues of patchy uptake. Variation in usage of bibliotherapy raises questions about equity; it is unlikely to reflect the distribution of people who could potentially benefit. Factors influencing variation existed all along the implementation chain. It is not always possibly to separate demand-side and supply-side factors when considering equity and service innovation in health care.

  12. Diversion of mentally disordered people from the criminal justice system in England and Wales: An overview.

    Science.gov (United States)

    James, David V

    2010-01-01

    The form that diversion mechanisms take in a given jurisdiction will be influenced both by mental health law and sentencing policies, and by the structure of criminal justice and health care systems. In England and Wales, treatment in hospital in lieu of any other sentence is available as a disposal option following a finding of guilt. In addition, there is a National Health Service, free at the point of delivery, the existence of which creates the potential for a co-ordinated nationwide response to mental disorder within the criminal justice system. In recent years, the National Health Service has taken over the delivery of health care in prisons, including psychiatric services, with the principle being one of equivalence between the quality of health provision provided in the community and that provided in prisons. However, problems within the system dictate that an important place remains for add-on diversion initiatives at courts and police stations, which aim to circumvent some of the delays in dealing with mentally disordered people or to prevent them entering the criminal justice system in the first place. It has been demonstrated that such mechanisms can be highly effective, and a government-sponsored review in 1992 recommended their general adoption. A lack of central co-ordination determined that progress was very slow. A new government-commissioned report in 2009 set out detailed recommendations for reform throughout the system. It laid emphasis on a co-ordinated response at all levels and between all agencies, and placed importance on linking initiatives with community services and with preventative measures, including attention to the effects of social exclusion. Some grounds for optimism exist, although there are particular problems in implementing change at a time of financial austerity. Copyright 2010 Elsevier Ltd. All rights reserved.

  13. Performance assessment for proposed disposal of NORM at an existing landfill in New South Wales, Australia

    Energy Technology Data Exchange (ETDEWEB)

    Fountain, S., E-mail: sfountain@geosyntec.com [Geosyntec Consultants, Inc., Kennesaw, Georgia (United States); Jones, J., E-mail: john.jones@sita.com.au [SITA Australia, Chullora, New South Wales (Australia); Christopherson, J.; Drummond, C., E-mail: jchristopherson@geosyntec.com, E-mail: cdrummond@geosyntec.com [Geosyntec Consultants, Inc., Orlando, FL (United States); Bruce, R.; Duffy, D., E-mail: rbruce@geosyntec.com, E-mail: dduffy@geosyntec.com [Geosyntec Consultants, Sdn. Bhd., Kuala Lumpur (Malaysia); Beech, J., E-mail: jbeech@geosyntec.com [Geosyntec Consultants, Inc., Kennesaw, Georgia (United States)

    2014-07-01

    Approximately 5,000 tonnes of soil containing naturally occurring radioactive materials (NORM), primarily consisting of the uranium and thorium series, were proposed to be removed from properties undergoing remedial action in New South Wales (NSW), Australia. These 'NORM soils' were proposed to be excavated and transported for disposal at an existing landfill facility in NSW. Once at the landfill facility and confirmed to meet appropriate acceptance criteria, the NORM soils were proposed to be disposed of in an encapsulated waste cell (EWC) within a previously permitted and constructed restricted solid waste (RSW) cell at the landfill. The characteristics of the NORM soils require that they be disposed of and managed in an appropriate manner, both near-term as well as beyond the time when the EWC liner system can be assumed to have degraded. A Performance Assessment (PA) was conducted to help assess the potential long-term incremental dose received by a target receptor group related to the disposal of the NORM soils at the landfill facility. The PA consisted of computing the doses to a designated receptor group associated with the planned disposal of the soils within the licensed RSW cell at the landfill facility. Primary tasks performed for this PA included conceptual site model (CSM) development, infiltration (Hydrologic Evaluation of Landfill Performance [HELP]) modeling, and radionuclide fate and transport and dose (RESidual RADioactivity-OFFSITE [RESRAD-OFFSITE]) modeling. The results of the PA indicated that the computed doses to the receptors associated with the disposal of NORM soils in the EWC within the RSW at the landfill facility was in compliance with both the current NSW Radiation Control Regulation 2013 and International Commission on Radiological Protection (ICRP) dose limits for the designated potential receptor group. (author)

  14. Is bigger better? An empirical analysis of waste management in New South Wales

    Energy Technology Data Exchange (ETDEWEB)

    Carvalho, Pedro, E-mail: pedrotcc@gmail.com [LAMEMO Laboratory, Department of Civil Engineering, Federal University of Rio de Janeiro, COPPE/UFRJ, Av. Pedro Calmon – Ilha do Fundão, 21941-596 Rio de Janeiro (Brazil); CESUR – Center for Urban and Regional Systems, Instituto Superior Técnico, University of Lisboa, Av. Rovisco Pais, 1049-001 Lisbon (Portugal); Marques, Rui Cunha, E-mail: rui.marques@tecnico.ulisboa.pt [CESUR – Center for Urban and Regional Systems, Instituto Superior Técnico, University of Lisboa, Av. Rovisco Pais, 1049-001 Lisbon (Portugal); Dollery, Brian, E-mail: bdollery@une.edu.au [CLG – Centre for Local Government, University of New England, Armidale, NSW (Australia); Faculty of Economics, Yokohama National University (Japan)

    2015-05-15

    Highlights: • We search for the most efficient cost structure for NSW household waste services. • We found that larger services are no longer efficient. • We found an optimal size for the range 12,000–20,000 inhabitants. • We found significant economies of output density for household waste collection. • We found economies of scope in joint provision of unsorted and recycling services. - Abstract: Across the world, rising demand for municipal solid waste services has seen an ongoing increase in the costs of providing these services. Moreover, municipal waste services have typically been provided through natural or legal monopolies, where few incentives exist to reduce costs. It is thus vital to examine empirically the cost structure of these services in order to develop effective public policies which can make these services more cost efficient. Accordingly, this paper considers economies of size and economies of output density in the municipal waste collection sector in the New South Wales (NSW) local government system in an effort to identify the optimal size of utilities from the perspective of cost efficiency. Our results show that – as presently constituted – NSW municipal waste services are not efficient in terms of costs, thereby demonstrating that ‘bigger is not better.’ The optimal size of waste utilities is estimated to fall in the range 12,000–20,000 inhabitants. However, significant economies of output density for unsorted (residual) municipal waste collection and recycling waste collection were found, which means it is advantageous to increase the amount of waste collected, but maintaining constant the number of customers and the intervention area.

  15. Nine key principles to guide youth mental health: development of service models in New South Wales.

    Science.gov (United States)

    Howe, Deborah; Batchelor, Samantha; Coates, Dominiek; Cashman, Emma

    2014-05-01

    Historically, the Australian health system has failed to meet the needs of young people with mental health problems and mental illness. In 2006, New South Wales (NSW) Health allocated considerable funds to the reform agenda of mental health services in NSW to address this inadequacy. Children and Young People's Mental Health (CYPMH), a service that provides mental health care for young people aged 12-24 years, with moderate to severe mental health problems, was chosen to establish a prototype Youth Mental Health (YMH) Service Model for NSW. This paper describes nine key principles developed by CYPMH to guide the development of YMH Service Models in NSW. A literature review, numerous stakeholder consultations and consideration of clinical best practice were utilized to inform the development of the key principles. Subsequent to their development, the nine key principles were formally endorsed by the Mental Health Program Council to ensure consistency and monitor the progress of YMH services across NSW. As a result, between 2008 and 2012 YMH Services across NSW regularly reported on their activities against each of the nine key principles demonstrating how each principle was addressed within their service. The nine key principles provide mental health services a framework for how to reorient services to accommodate YMH and provide a high-quality model of care. [Corrections added on 29 November 2013, after first online publication: The last two sentences of the Results section have been replaced with "As a result, between 2008 and 2012 YMH Services across NSW regularly reported on their activities against each of the nine key principles demonstrating how each principle was addressed within their service."]. © 2013 Wiley Publishing Asia Pty Ltd.

  16. Examining the uncertain origin and management role of martens on Prince of Wales Island, Alaska.

    Science.gov (United States)

    Pauli, Jonathan N; Moss, Wynne E; Manlick, Philip J; Fountain, Emily D; Kirby, Rebecca; Sultaire, Sean M; Perrig, Paula L; Mendoza, Jorge E; Pokallus, John W; Heaton, Timothy H

    2015-10-01

    Conservation biologists are generally united in efforts to curtail the spread of non-native species globally. However, the colonization history of a species is not always certain, and whether a species is considered non-native or native depends on the conservation benchmark. Such ambiguities have led to inconsistent management. Within the Tongass National Forest of Alaska, the status of American marten (Martes americana) on the largest, most biologically diverse and deforested island, Prince of Wales (POW), is unclear. Ten martens were released to POW in the early 1930s, and it was generally believed to be the founding event, although this has been questioned. The uncertainty surrounding when and how martens colonized POW complicates management, especially because martens were selected as a design species for the Tongass. To explore the history of martens of POW we reviewed other plausible routes of colonization; genetically and isotopically analyzed putative marten fossils deposited in the late Pleistocene and early Holocene to verify marten occupancy of POW; and used contemporary genetic data from martens on POW and the mainland in coalescent simulations to identify the probable source of the present-day marten population on POW. We found evidence for multiple routes of colonization by forest-associated mammals beginning in the Holocene, which were likely used by American martens to naturally colonize POW. Although we cannot rule out human-assisted movement of martens by Alaskan Natives or fur trappers, we suggest that martens be managed for persistence on POW. More generally, our findings illustrate the difficulty of labeling species as non-native or native, even when genetic and paleo-ecological data are available, and support the notion that community resilience or species invasiveness should be prioritized when making management decisions rather than more subjective and less certain conservation benchmarks. © 2015 Society for Conservation Biology.

  17. A human rights approach to advocacy for people with dementia: A review of current provision in England and Wales.

    Science.gov (United States)

    Dixon, Jeremy; Laing, Judy; Valentine, Christine

    2018-01-01

    In this article, we review current advocacy services for people with dementia in England and Wales (provided, respectively, under the Mental Capacity Act 2005 , the Mental Health Act 1983 /2007 and the Care Act 2014) through the lens of the United Nations Convention on the Rights of Persons with Disabilities (CRPD). We examine what a human rights' approach to advocacy support would entail, and whether current frameworks in England and Wales are adequate for this approach and provide a sufficient safeguard. First, we consider how the human rights of persons with dementia have become increasingly important and the extent to which the CRPD provides an opportunity to bolster safeguards and protection. Second, we discuss cause and case advocacy, and how these advocacy models could be shaped by the CRPD to promote the rights of persons with dementia at each stage of the disease. Third, we highlight current dilemmas and challenges in the provision of advocacy support in England and Wales by focusing on case law, commissioning of services and current practice. In particular, we analyse how the different legislative schemes have given rise to some confusion about the various advocacy provisions, as well as potential for overlap and discrepancies between different regimes. We also highlight the need for further research to address important gaps in knowledge, including the scale of need, patterns of referral and attitudes to advocacy services. The article concludes by highlighting how advocacy support could be recalibrated as a universal right to promote the aims and aspirations of the CRPD, and how education is needed to address the stigma of dementia and promote the benefits of advocacy in protecting the rights of those with dementia.

  18. National audit of pressure ulcers and incontinence-associated dermatitis in hospitals across Wales: a cross-sectional study.

    Science.gov (United States)

    Clark, Michael; Semple, Martin J; Ivins, Nicola; Mahoney, Kirsten; Harding, Keith

    2017-08-21

    The Chief Nurse National Health Service Wales initiated a national survey of acute and community hospital patients in Wales to identify the prevalence of pressure ulcers and incontinence-associated dermatitis. Teams of two nurses working independently assessed the skin of each inpatient who consented to having their skin observed. Over 28 September 2015 to 2nd October 2015, 8365 patients were assessed across 66 hospitals with 748 (8.9%) found to have pressure ulcers. Not all patients had their skin inspected with all mental health patients exempt from this part of the audit along with others who did not consent or were too ill. Of the patients with pressure ulcers, 593 (79.3%) had their skin inspected with 158 new pressure ulcers encountered that were not known to ward staff, while 152 pressure ulcers were incorrectly categorised by the ward teams. Incontinence-associated dermatitis was encountered in 360 patients (4.3%), while medical device-related pressure ulcers were rare (n=33). The support surfaces used while patients were in bed were also recorded to provide a baseline against which future changes in equipment procurement could be assessed. The presence of other wounds was also recorded with 2537 (30.3%) of all hospital patients having one or more skin wounds. This survey has demonstrated that although complex, it is feasible to undertake national surveys of pressure ulcers, incontinence-associated dermatitis and other wounds providing comprehensive and accurate data to help plan improvements in wound care across Wales. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  19. Vegetation and flora of Booti Booti National Park and Yahoo Nature Reserve, lower North Coast of New South Wales

    OpenAIRE

    Griffith, S. J.; Wilson, R.; Maryott-Brown, K.

    2015-01-01

    The vegetation of Booti Booti National Park and Yahoo Nature Reserve on the lower North Coast of New South Wales has been classified and mapped from aerial photography at a scale of 1:25,000. The plant communities so identified are described in terms of their composition and distribution within Booti Booti NP and Yahoo NR. The plant communities are also discussed in terms of their distribution elsewhere in south-eastern Australia, with particular emphasis given to the NSW North Coast where co...

  20. Does vertical integration have an effect on load factor? - A test on coal-fired plants in England and Wales

    International Nuclear Information System (INIS)

    Lopez, Jose A.; Salies, Evens

    2006-02-01

    Today in the British electricity industry, most electricity suppliers hedge a large proportion of their residential customer base requirements by owning their own plant. The non-storability of electricity and the corresponding need for an instantaneous matching of generation and consumption creates a business need for integration. From a sample of half-hour data on load factor for coal-fired power plants in England and Wales, this paper tests the hypothesis that vertical integration with retail businesses affects the extent to which producers utilize their capacity. We also pay attention to this potential effect during periods of peak demand. (authors)

  1. A national framework for flood forecasting model assessment for use in operations and investment planning over England and Wales

    Science.gov (United States)

    Moore, Robert J.; Wells, Steven C.; Cole, Steven J.

    2016-04-01

    It has been common for flood forecasting systems to be commissioned at a catchment or regional level in response to local priorities and hydrological conditions, leading to variety in system design and model choice. As systems mature and efficiencies of national management are sought, there can be a drive towards system rationalisation, gaining an overview of model performance and consideration of simplification through model-type convergence. Flood forecasting model assessments, whilst overseen at a national level, may be commissioned and managed at a catchment and regional level, take a variety of forms and be large in number. This presents a challenge when an integrated national assessment is required to guide operational use of flood forecasts and plan future investment in flood forecasting models and supporting hydrometric monitoring. This contribution reports on how a nationally consistent framework for flood forecasting model performance has been developed to embrace many past, ongoing and future assessments for local river systems by engineering consultants across England & Wales. The outcome is a Performance Summary for every site model assessed which, on a single page, contains relevant catchment information for context, a selection of overlain forecast and observed hydrographs and a set of performance statistics with associated displays of novel condensed form. One display provides performance comparison with other models that may exist for the site. The performance statistics include skill scores for forecasting events (flow/level threshold crossings) of differing severity/rarity, indicating their probability and likely timing, which have real value in an operational setting. The local models assessed can be of any type and span rainfall-runoff (conceptual and transfer function) and flow routing (hydrological and hydrodynamic) forms. Also accommodated by the framework is the national G2G (Grid-to-Grid) distributed hydrological model, providing area

  2. Comparison of accelerator and radiometric radiocarbon measurements obtained from Late Devensian Lateglacial lake sediments from Llyn Gwernan, North Wales, UK

    International Nuclear Information System (INIS)

    Lowe, J.J.; Lowe, S.; Fowler, A.J.

    1988-01-01

    Accelerator mass spectrometry measurements of the radiocarbon activity of various chemical fractions prepared from Late Devensian Lateglacial lake sediments from the site of Llyn Gwernan, near Cader Idris. North Wales are presented and assessed. These are compared with radiocarbon measurements obtained by radiometric (decay) counting which were reported earlier from the same site and are considered in the light of pollen-stratigraphic information. The potensial advantages of accelerator radiocarbon measurements to the assessment of the chronology and correlation of Lateglacial lake sediments are evaluated

  3. The importance of brain banks for molecular neuropathological research: The New South Wales Tissue Resource Centre experience.

    Science.gov (United States)

    Dedova, Irina; Harding, Antony; Sheedy, Donna; Garrick, Therese; Sundqvist, Nina; Hunt, Clare; Gillies, Juliette; Harper, Clive G

    2009-01-01

    New developments in molecular neuropathology have evoked increased demands for postmortem human brain tissue. The New South Wales Tissue Resource Centre (TRC) at The University of Sydney has grown from a small tissue collection into one of the leading international brain banking facilities, which operates with best practice and quality control protocols. The focus of this tissue collection is on schizophrenia and allied disorders, alcohol use disorders and controls. This review highlights changes in TRC operational procedures dictated by modern neuroscience, and provides examples of applications of modern molecular techniques to study the neuropathogenesis of many different brain disorders.

  4. Abrupt transition to heightened poliomyelitis epidemicity in England and Wales, 1947-1957, associated with a pronounced increase in the geographical rate of disease propagation.

    Science.gov (United States)

    Smallman-Raynor, M R; Cliff, A D

    2014-03-01

    The abrupt transition to heightened poliomyelitis epidemicity in England and Wales, 1947-1957, was associated with a profound change in the spatial dynamics of the disease. Drawing on the complete record of poliomyelitis notifications in England and Wales, we use a robust method of spatial epidemiological analysis (swash-backwash model) to evaluate the geographical rate of disease propagation in successive poliomyelitis seasons, 1940-1964. Comparisons with earlier and later time periods show that the period of heightened poliomyelitis epidemicity corresponded with a sudden and pronounced increase in the spatial rate of disease propagation. This change was observed for both urban and rural areas and points to an abrupt enhancement in the propensity for the geographical spread of polioviruses. Competing theories of the epidemic emergence of poliomyelitis in England and Wales should be assessed in the light of this evidence.

  5. Association between NICE guidance on biologic therapies with rates of hip and knee replacement among rheumatoid arthritis patients in England and Wales

    DEFF Research Database (Denmark)

    Hawley, Samuel; Cordtz, René; Dreyer, Lene

    2018-01-01

    OBJECTIVE: To estimate the impact of NICE approval of tumor necrosis factor inhibitor (TNFi) therapies on the incidence of total hip replacement (THR) and total knee replacement (TKR) among rheumatoid arthritis (RA) patients in England and Wales. METHODS: Primary care data [Clinical Practice.......92 PYs, respectively. NICE guidance was associated with a significant average decrease in TKR incidence of -4.41/1000 PYs (95% C.I. -6.88 to -1.94), equating to a relative 34% reduction. Overall, no effect was seen on THR rates. CONCLUSIONS: Among incident RA patients in England and Wales, NICE guidance...

  6. Perceiving prospects properly

    Czech Academy of Sciences Publication Activity Database

    Steiner, Jakub; Stewart, C.

    2016-01-01

    Roč. 106, č. 7 (2016), s. 1601-1631 ISSN 0002-8282 Institutional support: RVO:67985998 Keywords : evolution * perception bias * prospect theory Subject RIV: AH - Economics Impact factor: 4.026, year: 2016

  7. Inequalities in healthy life expectancy between ethnic groups in England and Wales in 2001.

    Science.gov (United States)

    Wohland, Pia; Rees, Phil; Nazroo, James; Jagger, Carol

    2015-01-01

    We aim to develop robust estimates of disability-free life expectancy (DFLE) and healthy life expectancy (HLE) for ethnic groups in England and Wales in 2001 and to examine observed variations across ethnic groups. DFLE and HLE by age and gender for five-year age groups were computed for 16 ethnic groups by combining the 2001 Census data on ethnicity, self-reported limiting long-term illness and self-rated health using mortality by ethnic group estimated by two methods: the Standardised Illness Ratio (SIR) method and the Geographically Weighted Method (GWM). The SIR and GWM methods differed somewhat in their estimates of life expectancy (LE) at birth but produced very similar estimates of DFLE and HLE by ethnic group. For the more conservative method (GWM), the range in DFLE at birth was 10.5 years for men and 11.9 years for women, double that in LE. DFLE at birth was highest for Chinese men (64.7 years, 95% CI 64.0-65.3) and women (67.0 years, 95% CI 66.4-67.6). Over half of the ethnic minority groups (men: 10; women: 9) had significantly lower DFLE at birth than White British men (61.7 years, 95% CI 61.7-61.7) or women (64.1 years, 95% CI 64.1-64.2), mostly the Black, Asian and mixed ethnic groups. The lowest DFLE observed was for Bangladeshi men (54.3 years, 95% CI 53.7-54.8) and Pakistani women (55.1 years, 95% CI 54.8-55.4). Notable were Indian women whose LE was similar to White British women but who had 4.3 years less disability-free (95% CI 4.0-4.6). Inequalities in DFLE between ethnic groups are large and exceed those in LE. Moreover, certain ethnic groups have a larger burden of disability that does not seem to be associated with shorter LE. With the increasing population of the non-White British community, it is essential to be able to identify the ethnic groups at higher risk of disability, in order to target appropriate interventions.

  8. The impacts of conifer harvesting on runoff water quality: a regional survey for Wales

    Directory of Open Access Journals (Sweden)

    C. Neal

    1998-01-01

    Full Text Available Major, minor and trace element chemistry of runoff at stormflow and baseflow from 67 catchments (2 to 5 ha in area has been determined to investigate the effects of clear felling and replanting of conifers on stream water quality across Wales. Samples, collected by local forestry workers (Forest Enterprise staff on a campaign basis on up to eight occasions, were for 16 mature first rotation standing forest: the remainder represented areas completely clear felled from less than one to up to forty years previously. As the waters drain acidic and acid sensitive soils, acidic runoff is often encountered. However, higher pH values with associated positive alkalinities and base cation enrichments are observed due to the influence of weathering reactions within the bedrock. There is little systematic variation in water quality between baseflow and stormflow for each site indicating a complex and erratic contribution of waters from the soil and underlying parent material. 80% or more of the data points show hardly any changes with felling time, but there are a few outlier points with much higher concentrations that provide important information on the processes operative. The clearest outlier felling response is for nitrate at five of the more recently felled sites on brown earth, gley and podzolic soil types. ANC, the prime indicator of stream acidity, shows a diverse response from both high to low outlier values (>+400 to -300 μEq/l. In parallel to nitrate, aluminium, potassium and barium concentrations are higher in waters sampled up to 4 years post felling, but the time series response is even less clear than that for nitrate. Cadmium, zinc and lead and lanthanides/actinides show large variations from site to site due to localized vein ore-mineralization in the underlying bedrock. The survey provides a strong indication that forest harvesting can have marked local effects on some chemical components of runoff for the first four years after felling

  9. Suicide and accidental deaths in children and adolescents in England and Wales, 2001-2010.

    Science.gov (United States)

    Windfuhr, Kirsten; While, David; Hunt, Isabelle M; Shaw, Jenny; Appleby, Louis; Kapur, Nav

    2013-12-01

    To investigate the impact of narrative verdicts on suicide statistics among 10-19-year-olds; to identify the number and rate of suicide and accidental deaths, particularly in 10-14-year-olds. National cohort study. England and Wales. Mid-year population estimates from the Office for National Statistics (ONS) were used to calculate rates per 100,000 population for suicide (undetermined and suicide verdicts) and accidental deaths (poisoning, hanging) for those aged 10-14 and 15-19. Trends in rates over time (2001-2010) were investigated using Poisson regression. Interaction tests were carried out to determine differences in trends between the two time periods (2001-2005 and 2006-2010). There were 1523 suicides (2.25/100,000). Suicide rates were highest in those aged 15-19 years (4.04/100,000) and in males (3.14/100,000). Between 2001 and 2010, rates significantly decreased among those aged 15-19 years (incidence rate-ratio (IRR): 0.95; 95% CI 0.93 to 0.97), with no change in rates of accidental deaths (IRR: 1.01, 95% CI 0.95 to 1.07). However, there was a significant interaction between the two time periods for accidental poisonings (2001-2005: IRR: 0.79 (95% CI 0.69 to 0.91); 2006-2010: IRR: 1.01 (95% CI 0.89 to 1.15), interaction p=0.012) and accidental hangings (2001-2005: IRR: 0.93 (95% CI 0.76 to 1.14); 2006-2010: IRR: 1.25 (95% CI 1.04 to 1.49), interaction=0.01) Undetermined deaths significantly decreased among females aged 15-19 yeras (IRR: 0.93; 95% CI 0.88 to 0.98). There were no significant trends among 10-14-year-olds. Rates of suicide are higher among older adolescents and males. There was a significant fall in suicide rates in males aged 15-19 years that was not accounted for by changes in rates of accidental death. The absence of a significant trend in suicide or accidental deaths in those aged 10-14 years may have been the result of small numbers. However, monitoring should continue to identify longitudinal trends in all young people.

  10. Wave climate change, coastline response and hazard prediction in New South Wales, Australia

    International Nuclear Information System (INIS)

    Goodwin, Ian D.; Verdon, Danielle; Cowell, Peter

    2007-01-01

    Full text: Full text: Considerable research effort has been directed towards understanding and the gross prediction of shoreline response to sea level rise (eg. Cowell ef a/. 2003a, b). In contrast, synoptic prediction of changes in the planform configuration of shorelines in response to changes in wind and wave climates over many decades has been limited by the lack of geohistorical data on shoreline alignment evolution and long time series of wave climate. This paper presents new data sets on monthly mean wave direction variability based on: a. Waverider buoy data; b. a reconstruction of monthly mid-shelf wave direction, 1877 to 2002 AD from historical MSLP data (Goodwin 2005); and c. a multi-decadal reconstruction of wave direction, in association with the Interdecadal Pacific Oscillation and the Southern Annular Mode of climate variability, covering the past millennium. A model of coastline response to the wave climate variability is presented for northern and central New South Wales (NSW) for decadal to multi-decadal time scales, and is based on instrumental and geohistorical data. The sensitivity of the coastline position and alignment, and beach state to mean and extreme wave climate changes is demonstrated (e.g. Goodwin et al. 2006). State changes in geometric shoreline alignment rotation, sand volume (progradation/recession) for NSW and mean wave direction, are shown to be in agreement with the low-frequency change in Pacific-wide climate. Synoptic typing of climate patterns using Self Organised Mapping methods is used to downscale CSIRO GCM output for this century. The synoptic types are correlated to instrumental wave climate data and coastal behaviour. The shifts in downscaled synoptic types for 2030 and 2070 AD are then used as the basis for predicting mean wave climate changes, coastal behaviour and hazards along the NSW coastline. The associated coastal hazards relate to the definition of coastal land loss through rising sea levels and shoreline

  11. Preventive care in general practice among healthy older New South Wales residents.

    Science.gov (United States)

    Harris, Mark F; Islam, Fakhrul Md; Jalaludin, Bin; Chen, Jack; Bauman, Adrian E; Comino, Elizabeth J

    2013-06-16

    Despite being at high risk, disadvantaged patients may be less likely to receive preventive care in general practice. This study aimed to explore self-reported preventive care received from general practitioners and the factors associated with this by healthy New South Wales (NSW) residents aged 45-74 years. A self-completed questionnaire was sent to 100,000 NSW residents in the 45 and Up cohort study. There was a 60% response rate. After exclusions there were 39,964 participants aged 45-74 years who did not report cardiovascular disease or diabetes. Dichotomised outcome variables were participant report of having had a clinical assessment of their blood pressure (BP), blood cholesterol (BC) or blood glucose (BG), or received advice to eat less high fat food, eat more fruit and vegetables or be more physically active from their GP in the last 12 months. Independent variables included socio-demographic, lifestyle risk factors, health status, access to health care and confidence in self-management. Most respondents reported having had their BP (90.6%), BC (73.9%) or BG (69.4%) assessed. Fewer reported being given health advice to (a)eat less high fat food (26.6%), (b) eat more fruit and vegetables (15.5%) or (c) do more physical activity (19.9%). The patterns of association were consistent with recognised need: participants who were older, less well educated or overweight were more likely to report clinical assessments; participants who were overseas born, of lower educational attainment, less confident in their own self-management, reported insufficient physical activity or were overweight were more likely to report receiving advice. However current smokers were less likely to report clinical assessments; and rural and older participants were less likely to receive diet or physical activity advice. This study demonstrated a gap between reported clinical assessments and preventive advice. There was evidence for inverse care for rural participants and smokers, who

  12. Bullying and sexual harassment of junior doctors in New South Wales, Australia: rate and reporting outcomes.

    Science.gov (United States)

    Llewellyn, Anthony; Karageorge, Aspasia; Nash, Louise; Li, Wenlong; Neuen, Dennis

    2018-02-16

    Objective The aim of this study was to describe rates of exposure to bullying and sexual harassment in junior doctors in first- or second-year prevocational medical training (PGY1 or PGY2 respectively) positions in New South Wales (NSW) and the Australian Capital Territory (ACT), and to explore the types of actions taken in response. Methods A cross-sectional survey of junior doctors in PGY1 or PGY2 positions was undertaken in 2015 and 2016 (n=374 and 440 respectively). Thematic analysis was undertaken on free-text responses to describe the reporting process and outcomes in more depth. Results The estimated response rate was 17-20%. Results from both surveys followed almost identical trends. Most respondents in 2015 and 2016 reported being bullied (n=203 (54.3%) and 253 (57.5%) respectively), 16-19% reported sexual harassment (n=58 and 82 respectively) and 29% of females reported sexual harassment. Qualitative analysis elucidated reasons for not taking action in response to bullying and harassment, including workplace normalisation of these behaviours, fear of reprisal and lack of knowledge or confidence in the reporting process. For respondents who did take action, most reported ineffective or personally harmful outcomes when reporting to senior colleagues, including being dismissed or blamed, and an intention not to trust the process in the future. Conclusions The findings suggest that interventions targeted at the level of junior doctors to improve the culture of bullying and harassment in medicine are unlikely to be helpful. Different approaches that address the problem in a more systemic way are needed, as is further research about the effectiveness of such interventions. What is known about the topic? Bullying and sexual harassment are common workplace experiences in the medical profession. What does this paper add? Over half the junior doctors in the present study experienced bullying and nearly one-fifth experienced sexual harassment. Junior doctors are

  13. Exploring interhospital transfers and partnerships in the hospital sector in New South Wales, Australia.

    Science.gov (United States)

    Assareh, Hassan; Achat, Helen M; Levesque, Jean-Frederic; Leeder, Stephen R

    2017-12-01

    Objective The aim of the present study was to explore characteristics of interhospital transfers (IHT) and sharing of care among hospitals in New South Wales (NSW), Australia. Methods Data were extracted from patient-level linked hospital administrative datasets for separations from all NSW acute care hospitals from 1 July 2013 to 30 June 2015. Patient discharge and arrival information was used to identify IHTs. Characteristics of patients and related hospitals were then analysed. Results Transfer-in patients accounted for 3.9% of all NSW admitted patients and, overall, 7.3% of NSW admissions were associated with transfers (IHT rate). Patients with injuries and circulatory system diseases had the highest IHT rate, accounting for one-third of all IHTs. Patients were more often transferred to larger than smaller hospitals (61% vs 29%). Compared with private hospitals, public hospitals had a higher IHT rate (8.4% vs 5.1%) and a greater proportion of transfer-out IHTs (52% vs 28%). Larger public hospitals had lower IHT rates (3-8%) compared with smaller public hospitals (13-26%). Larger public hospitals received and retransferred higher proportions of IHT patients (52-58% and 11% respectively) than their smaller counterparts (26-30% and 2-3% respectively). Less than one-quarter of IHTs were between the public and private sectors or between government health regions. The number of interacting hospitals and their interactions varied across hospital peer groups. Conclusion NSW IHTs were often to hospitals with greater speciality services. The patterns of interhospital interactions could be affected by organisational and regional preferences. What is known about the topic? IHTs aim to provide efficient and effective care. Nonetheless, information on transfers and the sharing of care among hospitals in an Australian setting is lacking. Studies of transfers and hospital partnership patterns will inform efforts to improve patient-centred transfers and hospital accountability

  14. The impacts of conifer harvesting on runoff water quality: a regional survey for Wales

    Science.gov (United States)

    Neal, C.; Reynolds, B.; Wilkinson, J.; Hill, T.; Neal, M.; Hill, S.; Harrow, M.

    Major, minor and trace element chemistry of runoff at stormflow and baseflow from 67 catchments (2 to 5 ha in area) has been determined to investigate the effects of clear felling and replanting of conifers on stream water quality across Wales. Samples, collected by local forestry workers (Forest Enterprise staff) on a campaign basis on up to eight occasions, were for 16 mature first rotation standing forest: the remainder represented areas completely clear felled from less than one to up to forty years previously. As the waters drain acidic and acid sensitive soils, acidic runoff is often encountered. However, higher pH values with associated positive alkalinities and base cation enrichments are observed due to the influence of weathering reactions within the bedrock. There is little systematic variation in water quality between baseflow and stormflow for each site indicating a complex and erratic contribution of waters from the soil and underlying parent material. 80% or more of the data points show hardly any changes with felling time, but there are a few outlier points with much higher concentrations that provide important information on the processes operative. The clearest outlier felling response is for nitrate at five of the more recently felled sites on brown earth, gley and podzolic soil types. ANC, the prime indicator of stream acidity, shows a diverse response from both high to low outlier values (>+400 to -300 μEq/l). In parallel to nitrate, aluminium, potassium and barium concentrations are higher in waters sampled up to 4 years post felling, but the time series response is even less clear than that for nitrate. Cadmium, zinc and lead and lanthanides/actinides show large variations from site to site due to localized vein ore-mineralization in the underlying bedrock. The survey provides a strong indication that forest harvesting can have marked local effects on some chemical components of runoff for the first four years after felling but that this is

  15. Predictors of illicit drug/s use among university students in Northern Ireland, Wales and England.

    Science.gov (United States)

    El Ansari, Walid; Vallentin-Holbech, Lotte; Stock, Christiane

    2014-12-16

    The use of illicit drug/s among university students is a public health concern. Nevertheless, many UK studies investigated a narrow spectrum of variables to explore their association/s with illicit drug/s use. We assessed the associations between a wide range of socio-demographic, health and wellbeing variables (independent variables) and having used illicit drug/s regularly, occasionally or never in life (dependent variables). Data (3706 students) were collected from seven universities in England, Wales, and Northern Ireland, using a self-administered questionnaire. About 5% of the sample had regularly used illicit drug/s, 25% occasionally, and 70% never. Regular drug use (RDU) was significantly more likely among males aged 21-29 years, daily smokers, those with heavy episodic drinking or possible alcohol dependency (CAGE test), and those who perceived their academic performance better than their peers. RDU was less likely among students with high health awareness and those living with parents. The predictors of occasional drug use (ODU) were similar to those of RDU. However, in addition, students with higher perceived stress were less likely, and students who felt financial burden/s were more likely to report ODU, while no association with academic performance was found. Never use of illicit drug/s was inversely associated with most of the variables listed above, and was positively associated with religiosity. Illicit drug/s use goes along with other substance use (alcohol and smoking). The finding that illicit drug/s use was higher among students reporting good academic performance was surprising and raises the question of whether illicit drug/s may be used as performance enhancing drugs. The factors identified with illicit drug/s use in this study could be utilized to develop appropriate public health policies and preventive measures for the health of students. Multilevel, value based, comprehensive, and strategic long-term intervention plans are required. This

  16. Ecological quality assessment of rivers and integrated catchment management in England and Wales

    Directory of Open Access Journals (Sweden)

    Paul LOGAN

    2001-09-01

    Full Text Available This paper deals with the ecological assessment of river quality and its relationship to integrated catchment management. The concept of catchment or river basin management has been a basic management tool in England and Wales since 1990; it is now being enshrined in the Water Framework Directive. Historically the statutory and operational drivers in the UK have lead to the development of distinctly different approaches to the management of water quality, water resources (quantity and physical river structure. More recently a proactive approach to the sustainable use of water promulgated in the Local Environment Agency Plans has also dealt with the three management aspects in some isolation although greater effort has been made to present the issues in an integrated manner. The Water Framework Directive calls for further integration in river basin plans and associated programmes of measures. In the paper the three approaches are described and considered in light of the requirements of the Water Framework Directive. Water Quality classification and objective setting has been based on information from the survey of benthic macro-invertebrates. The Biological Monitoring Working Party Score and the predictive software River Invertebrate Prediction and Classification System (RIVPACS have been used to set site-specific targets for management purposes. RIVPACS includes a reference database of minimally impacted sites for comparison with the observed data. This approach is in line with the requirements of the directive. Physical river structure work has been based on monitoring of in-river and river corridor characteristics. The River Habitat System (RHS has also developed a reference database but is less well developed in terms of its predictive ability. The use of ecological information in Water Resource management has taken a different approach based on the concept of differential ecological sensitivity to the hydrological regime within the river. In

  17. Acute costs and predictors of higher treatment costs of trauma in New South Wales, Australia.

    Science.gov (United States)

    Curtis, Kate; Lam, Mary; Mitchell, Rebecca; Black, Deborah; Taylor, Colman; Dickson, Cara; Jan, Stephen; Palmer, Cameron S; Langcake, Mary; Myburgh, John

    2014-01-01

    Accurate economic data are fundamental for improving current funding models and ultimately in promoting the efficient delivery of services. The financial burden of a high trauma casemix to designated trauma centres in Australia has not been previously determined, and there is some evidence that the episode funding model used in Australia results in the underfunding of trauma. To describe the costs of acute trauma admissions in trauma centres, identify predictors of higher treatment costs and cost variance in New South Wales (NSW), Australia. Data linkage of admitted trauma patient and financial data provided by 12 Level 1 NSW trauma centres for the 08/09 financial year was performed. Demographic, injury details and injury scores were obtained from trauma registries. Individual patient general ledger costs (actual trauma patient costs), Australian Refined Diagnostic Related Groups (AR-DRG) and state-wide average costs (which form the basis of funding) were obtained. The actual costs incurred by the hospital were then compared with the state-wide AR-DRG average costs. Multivariable multiple linear regression was used for identifying predictors of costs. There were 17,522 patients, the average per patient cost was $10,603 and the median was $4628 (interquartile range: $2179-10,148). The actual costs incurred by trauma centres were on average $134 per bed day above AR-DRG costs-determined costs. Falls, road trauma and violence were the highest causes of total cost. Motor cyclists and pedestrians had higher median costs than motor vehicle occupants. As a result of greater numbers, patients with minor injury had comparable total costs with those generated by patients with severe injury. However the median cost of severely injured patients was nearly four times greater. The count of body regions injured, sex, length of stay, serious traumatic brain injury and admission to the Intensive Care Unit were significantly associated with increased costs (p<0.001). This

  18. Pesticides and nitrate in groundwater underlying citrus croplands, Lake Wales Ridge, central Florida, 1999-2005.

    Science.gov (United States)

    Choquette, Anne F.

    2014-01-01

    This report summarizes pesticide and nitrate (as nitrogen) results from quarterly sampling of 31 surficial-aquifer wells in the Lake Wales Ridge Monitoring Network during April 1999 through January 2005. The wells, located adjacent to citrus orchards and used for monitoring only, were generally screened (sampled) within 5 to 40 feet of the water table. Of the 44 citrus pesticides and pesticide degradates analyzed, 17 were detected in groundwater samples. Parent pesticides and degradates detected in quarterly groundwater samples, ordered by frequency of detection, included norflurazon, demethyl norflurazon, simazine, diuron, bromacil, aldicarb sulfone, aldicarb sulfoxide, deisopropylatrazine (DIA), imidacloprid, metalaxyl, thiazopyr monoacid, oxamyl, and aldicarb. Reconnaissance sampling of five Network wells yielded detection of four additional pesticide degradates (hydroxysimazine, didealkylatrazine, deisopropylhydroxyatrazine, and hydroxyatrazine). The highest median concentration values per well, based on samples collected during the 1999–2005 period (n=14 to 24 samples per well), included 3.05 µg/L (micrograms per liter) (simazine), 3.90 µg/L (diuron), 6.30 µg/L (aldicarb sulfone), 6.85 µg/L (aldicarb sulfoxide), 22.0 µg/L (demethyl norflurazon), 25.0 µg/ (norflurazon), 89 µg/ (bromacil), and 25.5 mg/L (milligrams per liter) (nitrate). Nitrate concentrations exceeded the 10 mg/L (as nitrogen) drinking water standard in one or more groundwater samples from 28 of the wells, and the median nitrate concentration among these wells was 14 mg/L. Sampled groundwater pesticide concentrations exceeded Florida’s health-guidance benchmarks for aldicarb sulfoxide and aldicarb sulfone (4 wells), the sum of aldicarb and its degradates (6 wells), simazine (2 wells), the sum of simazine and DIA (3 wells), diuron (2 wells), bromacil (1 well), and the sum of norflurazon and demethyl norflurazon (1 well). The magnitude of fluctuations in groundwater pesticide

  19. Radioactive Substances Act 1960. Keeping and use of radioactive materials; list of registrations in England and Wales issued under the Radioactive Substances Act 1960 for the keeping and use of radioactive materials and mobile

    International Nuclear Information System (INIS)

    1989-05-01

    Through the Radioactive Substances Act 1960 (RSA 60), Her Majesty's Inspectorate of Pollution (Radioactive Substances) (HMIP) exercises control, on behalf of the Secretary of State for the Environment, over the keeping and use of radioactive material and the accumulation and disposal of radioactive waste in England. HMIP also provides technical advice to the Secretary of State for Wales in connection with the enforcement of RSA 60 in Wales. Registrations under RSA 60 for the keeping and use of radioactive materials in England and Wales are issued respectively by the Secretaries of State for the Environment and Wales, following careful assessment of the radiological consequences for members of the public. Registrations impose strict limits and conditions and premises and apparatus are subject to scrutiny by HMIP Inspectors to ensure compliance. A list contains names and addresses of those registered in England and Wales for the keeping and use of radioactive materials and mobile apparatus

  20. Monitoring travellers from Ebola-affected countries in New South Wales, Australia: what is the impact on travellers?

    Directory of Open Access Journals (Sweden)

    Jocelyn Chan

    2017-01-01

    Full Text Available Abstract Background Amidst an Ebola virus disease (EVD epidemic of unprecedented magnitude in west Africa, concerns about the risk of importing EVD led to the introduction of programs for the screening and monitoring of travellers in a number of countries, including Australia. Emerging reports indicate that these programs are feasible to implement, however rigorous evaluations are not yet available. We aimed to evaluate the program of screening and monitoring travellers in New South Wales. Methods We conducted a mixed methods study to evaluate the program of screening and monitoring travellers in New South Wales. We extracted quantitative data from the Notifiable Conditions Information Management System database and obtained qualitative data from two separate surveys of public health staff and arrivals, conducted by phone. Results Between 1 October 2014 and 13 April 2015, public health staff assessed a total of 122 out of 123 travellers. Six people (5% developed symptoms compatible with EVD and required further assessment. None developed EVD. Aid workers required lower levels of support compared to other travellers. Many travellers experienced stigmatisation. Public health staff were successful in supporting travellers to recognise and manage symptoms. Conclusion We recommend that programs for monitoring travellers should be tailored to the needs of different populations and include specific strategies to remediate stigmatisation.

  1. Socioeconomic position and subjective oral health: findings for the adult population in England, Wales and Northern Ireland.

    Science.gov (United States)

    Guarnizo-Herreño, Carol C; Watt, Richard G; Fuller, Elizabeth; Steele, Jimmy G; Shen, Jing; Morris, Stephen; Wildman, John; Tsakos, Georgios

    2014-08-09

    The objective of this study was to assess socioeconomic inequalities in subjective measures of oral health in a national sample of adults in England, Wales and Northern Ireland. We analysed data from the 2009 Adult Dental Health Survey for 8,765 adults aged 21 years and over. We examined inequalities in three oral health measures: self-rated oral health, Oral Health Impact Profile (OHIP-14), and Oral Impacts on Daily Performance (OIDP). Educational attainment, occupational social class and household income were included as socioeconomic position (SEP) indicators. Multivariable logistic regression models were fitted and from the regression coefficients, predictive margins and conditional marginal effects were estimated to compare predicted probabilities of the outcome across different SEP levels. We also assessed the effect of missing data on our results by re-estimating the regression models after imputing missing data. There were significant differences in predicted probabilities of the outcomes by SEP level among dentate, but not among edentate, participants. For example, persons with no qualifications showed a higher predicted probability of reporting bad oral health (9.1 percentage points higher, 95% CI: 6.54, 11.68) compared to those with a degree or equivalent. Similarly, predicted probabilities of bad oral health and oral impacts were significantly higher for participants in lower income quintiles compared to those in the highest income level (p oral health among adults in England, Wales and Northern Ireland with stronger gradients for those at younger ages.

  2. Use of programme budgeting and marginal analysis as a framework for resource reallocation in respiratory care in North Wales, UK.

    Science.gov (United States)

    Charles, J M; Brown, G; Thomas, K; Johnstone, F; Vandenblink, V; Pethers, B; Jones, A; Edwards, R T

    2016-09-01

    Since the global financial crisis, UK NHS spending has reduced considerably. Respiratory care is a large cost driver for Betsi Cadwaladr University Health Board, the largest health board in Wales. Under the remit of 'prudent healthcare' championed by the Welsh Health Minister, a Programme Budgeting Marginal Analysis (PBMA) of the North Wales respiratory care pathway was conducted. A PBMA panel of directors of medicines management, therapies finance, planning, public health and healthcare professionals used electronic voting to establish criteria for decision-making and vote on candidate interventions in which to disinvest and invest. A sum of £86.9 million was spent on respiratory care in 2012-13. Following extensive discussion of 13 proposed candidate interventions facilitated by a chairperson, 4 candidates received recommendations to disinvest, 7 to invest and 2 to maintain current activity. Marginal analysis prioritized mucolytics and high antibiotic prescribing as areas for disinvestment, and medicines waste management and pulmonary rehabilitation for investment. This exercise demonstrates the potential for health boards to use evidence-based approaches to reach potentially controversial disinvestment and investment decisions. Initial progress has begun with communication from the Medical Director in relation to the disinvestment in mucolytics prescribing and possible redirection of funding options being explored. © The Author 2015. Published by Oxford University Press on behalf of Faculty of Public Health.

  3. Results of national lake surveys 1995 in Finland, Norway, Sweden, Denmark, Russian Kola, Russian Karelia, Scotland and Wales

    Energy Technology Data Exchange (ETDEWEB)

    Henriksen, Arne; Skjelkvaale, Brit Lisa [Norsk Inst. for Vannforskning, Oslo (Norway); Mannio, Jaakko [FEI, (Finland)] [and others

    1997-12-31

    Beginning in 1995, national lake surveys were conducted in the above North European countries. This report provides the first united evaluation of lake water chemistry in Northern Europe. It was found that, except for Denmark, the water was characterized by low ionic strength and had low content of nitrogen and phosphorus. In Finland, Norway, Sweden, Russian Kola and Karelia more than 50% of the lakes had low critical load (CL) values for sulphur acidity (S), while Scotland, Wales and Denmark had very few lakes with low CL for S. The highest percentage (27%) of lakes with exceedence of CL for S was found in Norway, while the values for Russian Kola, Sweden and Finland were 17%, 9% and 9%, respectively. In Scotland and Wales, critical loads for sulphur acidity were exceeded in 1% of the total lake population. For Denmark and Russian Karelia, too few lakes were sampled to give reliable estimates. This adds up to approximately 22000 lakes in Northern Europe where CL for S was exceeded. However, this number of lakes is a minimum as exceedence of CL for N was not included in the calculation due to lack of catchment data. 26 refs., 21 figs., 13 tabs.

  4. Breaking The Link Between Legal Access To Alcohol And Motor Vehicle Accidents: Evidence From New South Wales.

    Science.gov (United States)

    Lindo, Jason M; Siminski, Peter; Yerokhin, Oleg

    2016-07-01

    A large literature has documented significant public health benefits associated with the minimum legal drinking age in the USA, particularly because of the resulting effects on motor vehicle accidents. These benefits form the primary basis for continued efforts to restrict youth access to alcohol. It is important to keep in mind that policymakers have a wide variety of alcohol-control options available to them, and understanding how these policies may complement or substitute for one another can improve policy making moving forward. Towards this end, we propose that investigating the causal effects of the minimum legal drinking age in New South Wales, Australia, provides a particularly informative case study, because Australian states are among the world leaders in their efforts against drunk driving. Using an age-based regression discontinuity design applied to restricted-use data from several sources, we find no evidence that legal access to alcohol has effects on motor vehicle accidents of any type in New South Wales, despite having large effects on drinking and on hospitalizations due to alcohol abuse. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

  5. Choose your menu wisely: cuisine-associated food-poisoning risks in restaurants in England and Wales.

    Science.gov (United States)

    Gormley, F J; Rawal, N; Little, C L

    2012-06-01

    The food service sector continues to be the most common setting for reported foodborne disease outbreaks in England and Wales. Using restaurant-associated foodborne outbreaks reported in England and Wales from 1992 to 2009, cuisine-specific risk factors were examined. Of 677 restaurant outbreaks, there were 11 795 people affected, 491 hospitalizations, and seven deaths; and Chinese, Indian, British and Italian cuisines were the most commonly implicated (26%, 16%, 13% and 10%, respectively). Salmonella spp. accounted for most outbreaks of all cuisine types, and particularly Chinese (76%, 133/175) and Italian (55%, 38/69). Poultry meat was the most frequently implicated food vehicle in outbreaks associated with Indian (30%), Chinese (21%), and British (18%) cuisines while for Italian cuisine, desserts and cakes were more frequently implicated (33%). Rice dishes were also a common outbreak food vehicle in those restaurants serving Chinese (22%) and Indian (16%) cuisine. Cross-contamination was the biggest contributory factor associated with Chinese (46%), British (33%) and Indian (30%) cuisines whereas inadequate cooking (38%) and use of raw shell eggs in lightly cooked or uncooked food (35%) were more often associated with Italian cuisine. Over the surveillance period, the proportion of Salmonella Enteritidis PT4 outbreaks in restaurants serving Chinese cuisine significantly decreased (Pcuisine type, specific evidence of food control failures can be used to target foodborne illness reduction strategies.

  6. The implementation of crisis resolution home treatment teams in wales: results of the national survey 2007-2008.

    Science.gov (United States)

    Jones, Richard; Jordan, Sue

    2010-02-18

    In mental health nursing, Crisis Resolution and Home Treatment (CRHT) services are key components of the shift from in-patient to community care. CRHT has been developed mainly in urban settings, and deployment in more rural areas has not been examined. We aimed to evaluate CRHT services' progress towards policy targets. All 18 CRHT teams in Wales were surveyed. A service profile questionnaire was distributed to team leaders. Fourteen of 18 teams responded in full. All but one were led by nurses, who formed the main professional group. All teams reported providing an alternative to hospital admission and assisting early discharge. With one exception, teams were 'gatekeeping' hospital beds. There was some divergence in clients seen, perceived impact of the service, operational hours, distances travelled, team structure, input of consultant psychiatrists and caseloads. We found some differences between the 8 urban teams and the 6 teams serving rural or mixed areas: rural teams travelled more, had fewer inpatient beds, and less medical input (0.067 compared to 0.688 whole time equivalents).. Most respondents felt that resource constraints were limiting further developments. Teams met standards for CHRT services in Wales; however, these are less onerous than those in England, particularly in relation to operational hours and staffing complement. As services develop, it will be important to ensure that rural and mixed areas receive the same level of input as urban areas.

  7. Derivatives in energy project finance

    International Nuclear Information System (INIS)

    Spencer, Lloyd

    1999-01-01

    This chapter focuses on risk management of merchant power generation projects and describes project finance as balancing risk and reward over time. The historical background to risk management is traced, and the case for derivatives in energy project finance is put forward with the hedging of forward output, and forwards and power purchase agreements discussed. Current and prospective usage, and the implementation issues of market liquidity, margin calls, letters of credit, derivative counterparty credit risk, and accounting policy are considered. A detailed example of a gas-fired plant in the US is presented with details given of the distribution of project earnings before tax. Oil field operating cashflows are examined, with reserved flow models, leverage effects, and price hedging addressed

  8. Worldwide prospects of uranium prospection and production

    International Nuclear Information System (INIS)

    Beaumont, Claude; Duval, B.C.; Sarcia, J.A.

    1978-01-01

    The reserves of uranium ores, at present known in the western world, at a mining price below 80 US dollars per kilo, permit the needs corresponding to the life of the existing reactors to be satisfied until 1988; the more expensive estimated resources taken into account would permit an extension beyond the end of the century. But the transition from available reserves and their renewal to the evaluated reserves necessitates from now a considerable prospecting effort. There are great geological possibilities to cover needs: beside the known types of deposits which give the present production, there exist numerous other prospects which appear of interest to underline; nevertheless, they require a certain amount of progress, other methods of detection such as the metal extractive processes which are not necessarily beyond the reach of science and techniques. Obstacles are due to the fact that the scrupules of ecologic necessities are often slightly inconsiderate, and that states intervene more and more in the extractive industry when the object is not to satisfy their own needs. Lastly, the uncertainty of the long market (breeder or not) risk to discourage the effort of investors [fr

  9. Psychological Types of Female Primary School Teachers in Anglican State-Maintained Schools in England and Wales: Implications for Continuing Professional Development

    Science.gov (United States)

    Francis, Leslie J.; Lankshear, David W.; Robbins, Mandy

    2011-01-01

    A sample of 221 female primary school teachers in Anglican state-maintained schools in England and Wales completed the Francis Psychological Type Scales (FPTS). The data demonstrated clear preferences for Extraversion (E) over Introversion (I), for Sensing (S) over Intuition (N), for Feeling (F) over Thinking (T) and for Judging (J) over…

  10. A Critical Discourse Analysis of the New Labour Discourse of Social and Emotional Learning (SEL) across Schools in England and Wales: Conversations with Policymakers

    Science.gov (United States)

    Emery, Carl

    2016-01-01

    This paper reports on a critical discourse analysis (CDA) of the New Labour (1997-2010) discourse of Social and Emotional Learning (SEL) in schools, and how it was understood and enacted by policymakers in England and in Wales within the context of devolved government across the UK. By SEL I mean universal school-based programs, located in the…

  11. ARSENIC REMOVAL FROM DRINKING WATER BY ADSORPTIVE MEDIA U.S. EPA DEMONSTRATION PROJECT AT SPRING BROOK MOBILE HOME PARK IN WALES, ME SIX-MONTH EVALUATION REPORT

    Science.gov (United States)

    This report documents the activities performed during and the results obtained from the first six months of the arsenic removal treatment technology demonstration project at the Spring Brook Mobile Home Park in Wales, ME. The objectives of the project are to evaluate the effectiv...

  12. FIRE STUDIES IN MALLEE (EUCALYPTUS SPP.) COMMUNITIES OF WESTERN NEW SOUTH WALES: SPATIAL AND TEMPORAL FLUXES IN SOIL CHEMISTRY AND SOIL BIOLOGY FOLLOWING PRESCRIBED FIRE.

    Science.gov (United States)

    The effects of prescribed fires on nutrient pools, soil-organisms, and vegetation patch dynamics were studied in three semi-arid mallee shrublands in western New South Wales. Repeated sampling of surface soil strata (0-2 and 2-4 cm) was undertaken at strategic times (immediately ...

  13. The Reliability of Free School Meal Eligibility as a Measure of Socio-Economic Disadvantage: Evidence from the Millennium Cohort Study in Wales

    Science.gov (United States)

    Taylor, Chris

    2018-01-01

    Over the last 20 years, the use of administrative data has become central to understanding pupil attainment and school performance. Of most importance has been its use to robustly demonstrate the impact of socio-economic status (SES) on pupil attainment. Much of this analysis in England and Wales has relied on whether pupils are eligible for free…

  14. A Critical Examination of the Introduction of Drug Detection Dogs for Policing of Illicit Drugs in New South Wales, Australia Using Kingdon's "Multiple Streams" Heuristic

    Science.gov (United States)

    Lancaster, Kari; Ritter, Alison; Hughes, Caitlin; Hoppe, Robert

    2017-01-01

    This paper critically analyses the introduction of drug detection dogs as a tool for policing of illicit drugs in New South Wales, Australia. Using Kingdon's "multiple streams" heuristic as a lens for analysis, we identify how the issue of drugs policing became prominent on the policy agenda, and the conditions under which the…

  15. The Spiritual Revolution and Suicidal Ideation: An Empirical Enquiry among 13- to 15-Year-Old Adolescents in England and Wales

    Science.gov (United States)

    Robbins, Mandy; Francis, Leslie J.

    2009-01-01

    The association between conventional religiosity and suicide inhibition has been well explored and documented since the pioneering work of Durkheim. Commentators like Heelas and Woodhead point to ways in which conventional religiosity is giving way in England and Wales to a range of alternative spiritualities, including renewed interest in…

  16. Modeling Water Utility Investments and Improving Regulatory Policies using Economic Optimisation in England and Wales

    Science.gov (United States)

    Padula, S.; Harou, J. J.

    2012-12-01

    Water utilities in England and Wales are regulated natural monopolies called 'water companies'. Water companies must obtain periodic regulatory approval for all investments (new supply infrastructure or demand management measures). Both water companies and their regulators use results from least economic cost capacity expansion optimisation models to develop or assess water supply investment plans. This presentation first describes the formulation of a flexible supply-demand planning capacity expansion model for water system planning. The model uses a mixed integer linear programming (MILP) formulation to choose the least-cost schedule of future supply schemes (reservoirs, desalination plants, etc.) and demand management (DM) measures (leakage reduction, water efficiency and metering options) and bulk transfers. Decisions include what schemes to implement, when to do so, how to size schemes and how much to use each scheme during each year of an n-year long planning horizon (typically 30 years). In addition to capital and operating (fixed and variable) costs, the estimated social and environmental costs of schemes are considered. Each proposed scheme is costed discretely at one or more capacities following regulatory guidelines. The model uses a node-link network structure: water demand nodes are connected to supply and demand management (DM) options (represented as nodes) or to other demand nodes (transfers). Yields from existing and proposed are estimated separately using detailed water resource system simulation models evaluated over the historical period. The model simultaneously considers multiple demand scenarios to ensure demands are met at required reliability levels; use levels of each scheme are evaluated for each demand scenario and weighted by scenario likelihood so that operating costs are accurately evaluated. Multiple interdependency relationships between schemes (pre-requisites, mutual exclusivity, start dates, etc.) can be accounted for by

  17. Marital history, health and mortality among older men and women in England and Wales.

    Science.gov (United States)

    Grundy, Emily M D; Tomassini, Cecilia

    2010-09-15

    Health benefits of marriage have long been recognised and extensively studied but previous research has yielded inconsistent results for older people, particularly older women. At older ages accumulated benefits or disadvantages of past marital experience, as well as current marital status, may be relevant, but fewer studies have considered effects of marital history. Possible effects of parity, and the extent to which these may contribute to marital status differentials in health, have also been rarely considered. We use data from the Office for National Statistics Longitudinal Study, a large record linkage study of 1% of the population of England & Wales, to analyse associations between marital history 1971-1991 and subsequent self-reported limiting long-term illness and mortality in a cohort of some 75,000 men and women aged 60-79 in 1991. We investigate whether prior marital status and time in current marital status influenced risks of mortality or long term illness using Poisson regression to analyse mortality differentials 1991-2001 and logistic regression to analyse differences in proportions reporting limiting long-term illness in 1991 and 2001. Co-variates included indicators of socio-economic status at two or three points of the adult life course and, for women, number of children borne (parity). Relative to men in long-term first marriages, never-married men, widowers with varying durations of widowerhood, men divorced for between 10 and twenty years, and men in long-term remarriages had raised mortality 1991-2001. Men in long-term remarriages and those divorced or widowed since 1971 had higher odds of long-term illness in 1991; in 2001 the long-term remarried were the only group with significantly raised odds of long-term illness. Among women, the long-term remarried also had higher odds of reporting long-term illness in 1991 and in 2001 and those remarried and previously divorced had raised odds of long-term illness and raised mortality 1991-2001; this

  18. Marital history, health and mortality among older men and women in England and Wales

    Directory of Open Access Journals (Sweden)

    Tomassini Cecilia

    2010-09-01

    Full Text Available Abstract Background Health benefits of marriage have long been recognised and extensively studied but previous research has yielded inconsistent results for older people, particularly older women. At older ages accumulated benefits or disadvantages of past marital experience, as well as current marital status, may be relevant, but fewer studies have considered effects of marital history. Possible effects of parity, and the extent to which these may contribute to marital status differentials in health, have also been rarely considered. Methods We use data from the Office for National Statistics Longitudinal Study, a large record linkage study of 1% of the population of England & Wales, to analyse associations between marital history 1971-1991 and subsequent self-reported limiting long-term illness and mortality in a cohort of some 75,000 men and women aged 60-79 in 1991. We investigate whether prior marital status and time in current marital status influenced risks of mortality or long term illness using Poisson regression to analyse mortality differentials 1991-2001 and logistic regression to analyse differences in proportions reporting limiting long-term illness in 1991 and 2001. Co-variates included indicators of socio-economic status at two or three points of the adult life course and, for women, number of children borne (parity. Results Relative to men in long-term first marriages, never-married men, widowers with varying durations of widowerhood, men divorced for between 10 and twenty years, and men in long-term remarriages had raised mortality 1991-2001. Men in long-term remarriages and those divorced or widowed since 1971 had higher odds of long-term illness in 1991; in 2001 the long-term remarried were the only group with significantly raised odds of long-term illness. Among women, the long-term remarried also had higher odds of reporting long-term illness in 1991 and in 2001 and those remarried and previously divorced had raised odds of

  19. Late Glacial-Holocene Pollen-Based Vegetation History from Pass Lake, Prince of Wales Island, Southeastern Alaska

    Science.gov (United States)

    Ager, Thomas A.; Rosenbaum, Joseph G.

    2009-01-01

    A radiocarbon-dated history of vegetation development since late Wisconsin deglaciation has been reconstructed from pollen evidence preserved in a sediment core from Pass Lake on Prince of Wales Island, southeastern Alaska. The shallow lake is in the south-central part of the island and occupies a low pass that was filled by glacial ice of local origin during the late Wisconsin glaciation. The oldest pollen assemblages indicate that pine woodland (Pinus contorta) had developed in the area by ~13,715 cal yr B.P. An abrupt decline in the pine population, coinciding with expansion of alder (Alnus) and ferns (mostly Polypodiaceae) began ~12,875 yr B.P., and may have been a response to colder, drier climates during the Younger Dryas climatic interval. Mountain hemlock (Tsuga mertensiana) began to colonize central Prince of Wales Island by ~11,920 yr B.P. and was soon followed by Sitka spruce (Picea sitchensis). Pollen of western hemlock (Tsuga heterophylla) began to appear in Pass Lake sediments soon after 11,200 yr B.P. The abundance of western hemlock pollen in the Pass Lake core during most of the Holocene appears to be the result of wind transport from trees growing at lower altitudes on the island. The late Holocene pollen record from Pass Lake is incomplete because of one or more unconformities, but the available record suggests that a vegetation change occurred during the late Holocene. Increases in pollen percentages of pine, cedar (probably yellow cedar, Chamaecyparis nootkatensis), and heaths (Ericales) suggest an expansion of muskeg vegetation occurred in the area during the late Holocene. This vegetation change may be related to the onset of cooler, wetter climates that began as early as ~3,774 yr B.P. in the region. This vegetation history provides the first radiocarbon-dated Late Glacial-Holocene terrestrial paleoecological framework for Prince of Wales Island. An analysis of magnetic properties of core sediments from Pass Lake suggests that unconformities

  20. Classification and evaluation of the functional results of replanted parts of the hand at the Prince of Wales Hospital and the Prince of Wales Children's Hospital: 1984 to 1988.

    Science.gov (United States)

    Milroy, B C; Sackelariou, R P; Lendvay, P G; Baldwin, M R; McGlynn, M

    1991-01-01

    This paper describes a simple method of classification and evaluation of the functional results of replanted and revascularized parts in the hand. The results are presented in graphic form and have been analyzed to correlate various factors: injured part, cause, and zone (level) of injury. The type of injury, ischemic time and age have been studied in more detail to determine their influence of the final functional result. The series contains 187 amputated and devascularized parts of the hand in 119 patients who have undergone surgery at the Prince of Wales Hospital from 1984 through 1988. The length of cold or warm ischemic times, up to 16 hours in this series, while not affecting survival of the amputated part, does adversely affect the functional result. The survival rate of replanted parts in children was significantly less favorable than in adults, but the functional results were uniformly superior.

  1. Asteroids. Prospective energy and material resources

    Energy Technology Data Exchange (ETDEWEB)

    Badescu, Viorel (ed.) [Bucharest Polytechnic Univ. (Romania). Candida Oancea Institute

    2013-11-01

    Recent research on Prospective Energy and Material Resources on Asteroids. Carefully edited book dedicated to Asteroids prospective energy and material resources. Written by leading experts in the field. The Earth has limited material and energy resources while these resources in space are virtually unlimited. Further development of humanity will require going beyond our planet and exploring of extraterrestrial resources and sources of unlimited power. Thus far, all missions to asteroids have been motivated by scientific exploration. However, given recent advancements in various space technologies, mining asteroids for resources is becoming ever more feasible. A significant portion of asteroids value is derived from their location; the required resources do not need to be lifted at a great expense from the surface of the Earth. Resources derived from Asteroid not only can be brought back to Earth but could also be used to sustain human exploration of space and permanent settlements in space. This book investigates asteroids' prospective energy and material resources. It is a collection of topics related to asteroid exploration, and utilization. It presents past and future technologies and solutions to old problems that could become reality in our life time. The book therefore is a great source of condensed information for specialists involved in current and impending asteroid-related activities and a good starting point for space researchers, inventors, technologists and potential investors. Written for researchers, engineers, and businessmen interested in asteroids' exploration and exploitation.

  2. Experiences of Autism Spectrum Disorder and Policing in England and Wales: Surveying Police and the Autism Community.

    Science.gov (United States)

    Crane, Laura; Maras, Katie L; Hawken, Tamsyn; Mulcahy, Sue; Memon, Amina

    2016-06-01

    An online survey gathered the experiences and views of 394 police officers (from England and Wales) regarding autism spectrum disorder (ASD). Just 42 % of officers were satisfied with how they had worked with individuals with ASD and reasons for this varied. Although officers acknowledged the need for adjustments, organisational/time constraints were cited as barriers. Whilst 37 % of officers had received training on ASD, a need for training tailored to policing roles (e.g., frontline officers, detectives) was identified. Police responses are discussed with respect to the experiences of the ASD community (31 adults with ASD, 49 parents), who were largely dissatisfied with their experience of the police and echoed the need for police training on ASD.

  3. An outbreak of Salmonella dublin infection in England and Wales associated with a soft unpasteurized cows' milk cheese.

    Science.gov (United States)

    Maguire, H; Cowden, J; Jacob, M; Rowe, B; Roberts, D; Bruce, J; Mitchell, E

    1992-12-01

    An outbreak of Salmonella dublin infection occurred in England and Wales in October to December 1989. Forty-two people were affected, mainly adults, and most lived in south-east England. Microbiological and epidemiological investigations implicated an imported Irish soft unpasteurized cows' milk cheese as the vehicle of infection. A case-control study showed a statistically significant association between infection and consumption of the suspect cheese (p = 0.001). Salmonella dublin was subsequently isolated from cheeses obtained from the manufacturer's premises. Initial control measures included the withdrawal of the cheese from retail sale and a Food Hazard Warning to Environmental Health Departments, as well as a press release, from the Department of Health. Subsequently, a decision was taken by the manufacturer to pasteurize milk used in the production of cheese for the UK market and importation of the cheese resumed in June 1990.

  4. Motion control in double-walled carbon nanotube systems using a Stone-Thrower-Wales defect cluster

    International Nuclear Information System (INIS)

    Liu Ping; Zhang Yongwei

    2010-01-01

    The ability to control the motion of a single molecule will have an important impact in nano-mechanical systems. Multi-walled carbon nanotube systems, which have extremely low intertube friction and strong motion confinement, can form the basis for mechanically based motion control. We devise two molecular motion control units based on double-walled carbon nanotubes embedded with a Stone-Thrower-Wales defect cluster, and perform molecular dynamics simulations to determine the characteristics of these two control units. We show that one of the molecular control units is able to perform a logic operation on one logic input and produce three logic outputs, while the other is able to produce two logic outputs. Potential applications of the motion control units include molecular switches, shuttles and mechanically based logic devices.

  5. Cross-sectional survey of antibiotic resistance in Escherichia coli isolated from diseased farm livestock in England and Wales.

    Science.gov (United States)

    Cheney, T E A; Smith, R P; Hutchinson, J P; Brunton, L A; Pritchard, G; Teale, C J

    2015-09-01

    Between 2005 and 2007, E. coli obtained from clinical diagnostic submissions from cattle, goats, pigs and sheep to government laboratories in England and Wales were tested for sensitivity to 16 antimicrobials. Resistance was most commonly observed against ampicillin, streptomycin, sulphonamides and tetracyclines. Resistance levels varied significantly between species, with isolates from cattle frequently showing the highest levels. Verocytotoxigenic E. coli (VTEC) expressed less resistance than non-VTEC. Only 19·3% of non-VTEC and 43·5% of VTEC were susceptible to all antimicrobials, while 47·1% and 30·4%, respectively, were resistant to ⩾5 antimicrobials. The resistance phenotype SSuT was commonly observed, and isolates resistant to third-generation cephalosporins were also identified. We recommend judicious antimicrobial usage in the livestock industry in order to preserve efficacy.

  6. Unemployment and inflammatory markers in England, Wales and Scotland, 1998-2012: Meta-analysis of results from 12 studies.

    Science.gov (United States)

    Hughes, Amanda; Kumari, Meena; McMunn, Anne; Bartley, Mel

    2017-08-01

    Unemployment represents for many affected individuals a substantial source of psychosocial stress, and is linked to both increased risk of morbidity and mortality and adverse health-related behaviours. Few studies have examined the association of unemployment with systemic inflammation, a plausible mediator of the associations of psychosocial stress and health, and results are mixed and context dependent. This study examines the association of unemployment with C-reactive protein (CRP) and fibrinogen, two markers of systemic inflammation. A random-effects meta-analysis was performed using a multilevel modelling approach, including 12 national UK surveys of working-age participants in which CRP and fibrinogen were measured between 1998 and 2012 (N=30,037 economically active participants). The moderating impact of participant age and UK country was explored. CRP and fibrinogen were elevated in unemployed compared to employed participants; jobseekers were also more likely (Odds Ratio: 1.39, p3mg/L), after adjustment for age, gender, education, long-term illness, smoking, and body mass index. Associations were not explained by mental health. Associations peaked in middle-age, and were stronger in Scotland and Wales than in England. Our study demonstrates that systemic inflammation is associated with an important but little-studied aspect of the social environment, as it is elevated in unemployed compared to employed survey participants. Modifications suggest the association of unemployment and inflammation is substantially influenced by contextual factors, and may be especially strong in Wales, where further investigation of this relationship is needed. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  7. Review of Historic Parishes of England and Wales: An Electronic Map of Boundaries before 1850 with a Gazetteer and Metadata.

    Directory of Open Access Journals (Sweden)

    Thomas Pickles

    2002-11-01

    Full Text Available According to the authors, Historic Parishes of England and Wales aims to provide one possible solution to 'a major lacuna militating against the effective exploitation of many post-medieval to mid-Victorian historical sources collected by local administrative areas.' That is 'the lack of information on the boundaries of those administrative areas: the so-called "historic" or "ancient" parishes of England and Wales.' There is no doubt that this is indeed a problem, and that such information will find a wide potential audience. As they admirably illustrate in the accompanying book, parish boundaries have been some of the most enduring and stable organising units, certainly formed by the thirteenth century and largely unchanged until the nineteenth. However, a series of Victorian parliamentary acts sought to rationalise the parochial pattern, and no national sources exist that record the status quo preceding these changes. Kain and Oliver point to an impressive number of historians of locally compiled sources who would benefit from reliable information on these pre-Victorian boundaries, and their list is by no means exhaustive. The core of the package is a database of 'metadata', intended for use with either Acrobat Reader or Microsoft Excel, which records the character of each administrative unit mapped, and the origins of the evidence for its boundaries. Three CDs contain this database in addition to maps of the 'historic' parish boundaries of England that can be read using Acrobat Reader, with the necessary reader software supplied. A further six CDs contain those same maps saved as three separate interactive layers, to be viewed using Adobe Illustrator but this software is not included.

  8. Evidence for deep sub-surface flow routing in forested upland Wales: implications for contaminant transport and stream flow generation

    Directory of Open Access Journals (Sweden)

    A. H. Haria

    2004-01-01

    Full Text Available Upland streamflow generation has traditionally been modelled as a simple rainfall-runoff mechanism. However, recent hydrochemical studies conducted in upland Wales have highlighted the potentially important role of bedrock groundwater in streamflow generation processes. To investigate these processes, a detailed and novel field study was established in the riparian zone and lower hillslopes of the Hafren catchment at Plynlimon, mid-Wales. Results from this study showed groundwater near the river behaving in a complex and most likely confined manner within depth-specific horizons. Rapid responses to rainfall in all boreholes at the study site indicated rapid recharge pathways further upslope. The different flow pathways and travel times influenced the chemical character of groundwaters with depth. Groundwaters were shown to discharge into the stream from the fractured bedrock. A lateral rapid flow horizon was also identified as a fast flow pathway immediately below the soils. This highlighted a mechanism whereby rising groundwater may pick up chemical constituents from the lower soils and transfer them quickly to the stream channel. Restrictions in this horizon resulted in groundwater upwelling into the soils at some locations indicating soil water to be sourced from both rising groundwater and rainfall. The role of bedrock groundwater in upland streamflow generation is far more complicated than previously considered, particularly with respect to residence times and flow pathways. Hence, water quality models in upland catchments that do not take account of the bedrock geology and the groundwater interactions therein will be seriously flawed. Keywords: bedrock, groundwater, Hafren, hillslope hydrology, Plynlimon, recharge, soil water, streamflow generation

  9. On Tour with the Prince: Monarchy, Imperial Politics and Publicity in the Prince of Wales's Dominion Tours 1919-20.

    Science.gov (United States)

    Mort, Frank

    2018-03-01

    The stage managers of ritual and the media transformed the British monarchy in the late-nineteenth and early-twentieth century, consolidating its image as splendid and popular and also as more accessible and quasi-democratic. Historians have emphasized that these processes of modernization largely began in Britain. This article locates the origins of democratized royal ritual in the white dominions, especially after 1918. Canada, Australia and New Zealand were political and cultural laboratories where royal advisors and British and dominion politicians launched experiments in the practice of progressive empire and innovatory styles of informal ceremonial, which had a long-term impact on imperial and later Commonwealth relations. Focusing on the Prince of Wales's early dominion tours, the article argues that though royal diplomacy followed earlier itineraries in efforts to consolidate the racialized British world, it also threw up new and unintended consequences. These registered the rapidly changing international order after the collapse of the European monarchies, together with the demands of the prince's own modernist personality. Faced with republican and socialist opposition in Australia and Canada, the touring prince was drawn into competing forms of nationalism, as dominion politicians and journalists embraced him as representing domestic aspirations for self-government and cultural recognition. It is argued that modern royalty personified by the Prince of Wales problematizes the history of twentieth-century public reputations defined by the culture of celebrity. The British monarchy was forced to confront both the constitutional claims of empire and the politics of dominion nationalism, as well as the pressures of international publicity.

  10. Campylobacter epidemiology: a descriptive study reviewing 1 million cases in England and Wales between 1989 and 2011.

    Science.gov (United States)

    Nichols, Gordon L; Richardson, Judith F; Sheppard, Samuel K; Lane, Chris; Sarran, Christophe

    2012-01-01

    To review Campylobacter cases in England and Wales over 2 decades and examine the main factors/mechanisms driving the changing epidemiology. A descriptive study of Campylobacter patients between 1989 and 2011. Cases over 3 years were linked anonymously to postcode, population density, deprivation indices and census data. Cases over 5 years were anonymously linked to local weather exposure estimates. Patients were from general practice, hospital and environmental health investigations through primary diagnostic laboratories across England and Wales. There were 1 109 406 cases. Description of changes in Campylobacter epidemiology over 23 years and how the main drivers may influence these. There was an increase in Campylobacter cases over the past 23 years, with the largest increase in people over 50 years. Changes in the underlying population have contributed to this, including the impacts of population increases after World War I, World War II and the 'baby boom' of the 1960s. A recent increase in risk or ascertainment within this population has caused an increase in cases in all age groups from 2004 to 2011. The seasonal increase in cases between weeks 18 (Early May) and 22 (Early June) was consistent across ages, years and regions and was most marked in children and in more rural regions. Campylobacter prevalence by week in each region correlated with temperature 2 weeks before. There were higher prevalences in areas with a low population density, low deprivation and lower percentage of people of ethnic origin. Data from sero-phage and multilocus sequence typing show a few common types and many uncommon types. The drivers/mechanisms influencing seasonality, age distribution, population density, socioeconomic and long-term differences are diverse and their relative contributions remain to be established. Surveillance and typing provide insights into Campylobacter epidemiology and sources of infection, providing a sound basis for targeted interventions.

  11. Rural-urban variation in injury-related hospitalisation, health outcomes and treatment cost in New South Wales.

    Science.gov (United States)

    Mitchell, Rebecca J; Lower, Tony

    2018-04-19

    To compare differences in injury characteristics, health outcomes and treatment costs between urban and rural residents who were hospitalised following an injury. A retrospective examination of injury-linked hospitalisation and mortality data in New South Wales from 1 January 2010 to 30 June 2014. Urban (496 325) and rural (213 139) residents who were hospitalised following an injury. Demographic and injury characteristics, injury severity, hospital length of stay, 28-day hospital readmission, 90-day mortality and treatment cost. Rural residents had an increased likelihood of being hospitalised for injuries from motorcycles, vehicles, animate causes, venomous animals or plants and assault compared to urban residents. Rural residents were less likely to be readmitted to hospital within 28 days and had a lower length of stay and age-adjusted length of stay than urban residents. Injury-related hospitalisations for urban and rural residents cost $4.4 billion and $1.7 billion, respectively. Annually, acute injury treatment ($1.1 billion), rehabilitation ($130 million) and subacute non-acute patient care ($57 million) cost $1.3 billion ($990 million for urban and $384 million for rural residents) in New South Wales. Fall-related injuries and transport incidents were the costliest injury mechanisms for both urban and rural residents. Injuries contribute substantially to hospitalised morbidity and its cost. The development and implementation of injury prevention strategies targeting the most common injuries for urban and rural residents will go some way towards reducing hospitalised injury and its cost. © 2018 National Rural Health Alliance Ltd.

  12. The midwife-woman relationship in a South Wales community: Experiences of midwives and migrant Pakistani women in early pregnancy.

    Science.gov (United States)

    Goodwin, Laura; Hunter, Billie; Jones, Aled

    2018-02-01

    In 2015, 27.5% of births in England and Wales were to mothers born outside of the UK. Compared to their White British peers, minority ethnic and migrant women are at a significantly higher risk of maternal and perinatal mortality, along with lower maternity care satisfaction. Existing literature highlights the importance of midwife-woman relationships in care satisfaction and pregnancy outcomes; however, little research has explored midwife-woman relationships for migrant and minority ethnic women in the UK. A focused ethnography was conducted in South Wales, UK, including semi-structured interviews with 9 migrant Pakistani participants and 11 practising midwives, fieldwork in the local migrant Pakistani community and local maternity services, observations of antenatal appointments, and reviews of relevant media. Thematic data analysis was undertaken concurrently with data collection. The midwife-woman relationship was important for participants' experiences of care. Numerous social and ecological factors influenced this relationship, including family relationships, culture and religion, differing health-care systems, authoritative knowledge and communication of information. Marked differences were seen between midwives and women in the perceived importance of these factors. Findings provide new theoretical insights into the complex factors contributing to the health-care expectations of pregnant migrant Pakistani women in the UK. These findings may be used to create meaningful dialogue between women and midwives, encourage women's involvement in decisions about their health care and facilitate future midwifery education and research. Conclusions are relevant to a broad international audience, as achieving better outcomes for migrant and ethnic minority communities is of global concern. © 2017 The Authors Health Expectations Published by John Wiley & Sons Ltd.

  13. Trends in drug overdose deaths in England and Wales 1993-98: methadone does not kill more people than heroin.

    Science.gov (United States)

    Hickman, Matthew; Madden, Peter; Henry, John; Baker, Allan; Wallace, Chris; Wakefield, Jon; Stimson, Gerry; Elliott, Paul

    2003-04-01

    To test the hypothesis that methadone is responsible for a greater increase in overdose deaths than heroin, and causes proportionally more overdose deaths than heroin at weekends. Multivariate analysis of 3961 death certificates mentioning heroin, morphine and/or methadone held on the Office for National Statistics drug-related poisoning mortality database from 1993 to 1998 in England and Wales. Percentage increase in deaths by year by drug, odds ratio (OR) of dying at the weekend from methadone-related overdose compared to dying from heroin/morphine overdose. From 1993 to 1998, annual opiate overdose deaths increased from 378 to 909. There was a 24.7% (95% confidence interval (CI) 22-28%) yearly increase in heroin deaths compared to 9.4% (95% CI 6-13%) for methadone only. This difference was significant (P < 0.001 by test of interaction) after adjustment for sex, age group, polydrug use, area of residence and underlying cause of death. The largest number of deaths occurred on Saturday (673). The OR of death from methadone overdose on Saturday and Sunday was 1.48 (95% CI 1.29-1.71) for methadone-only deaths compared to dying from heroin/morphine at the weekend after adjustment for other covariates, but the OR was not significant (1.09, 95% CI 0.95-1.25) if the weekend was defined as Friday and Saturday. There was no evidence that the threefold increase in deaths over time was due to methadone. There was equivocal support only for the hypothesis that there was an excess of deaths from methadone at weekends. Increased interventions to prevent overdose among injectors in England and Wales are long overdue.

  14. The traditional commons of England and Wales in the twenty-first century: meeting new and old challenges

    Directory of Open Access Journals (Sweden)

    Chris Short

    2008-07-01

    Full Text Available The commons literature makes much of the changes within the traditional land use sectors of developed countries. This largely focuses on the decline of the economic function of commons that threaten their existence, the emergence of multiple use patterns, and the resilience and policy adaptation needed to continue. The situation in England and Wales is used to illustrate that commons are increasingly important to a number of ‘new’ rural functions and that the associated policy developments may hold an important message for progress towards sustainable multifunctional land management more generally. This article reviews and updates what is meant by the term common land within England and Wales, while outlining its current importance and threats. The commons literature is investigated to see if the approach is useful in revealing the current issues associated with the incorporation of new stakeholders and functions within a traditional structure. Recent changes and developments surrounding the Commons Act 2006 are assessed to see if they are likely to assist in sustaining these commons through the twenty-first century. The article argues that any new approach requires long term planning and a commitment to support local participation among commoners and others who are involved in the governance and management of these areas of land. In order for these challenges to be met there needs to be an understanding of the functions and cultural traditions of common land as well as of the changes in society associated with the decline in traditional agrarian management in developed countries. Such challenges can rarely if ever be achieved through legislation and policy developments, requiring an investment in developing locally based solutions.

  15. The spatialities of ageing: Evidencing increasing spatial polarisation between older and younger adults in England and Wales

    Directory of Open Access Journals (Sweden)

    Albert Sabater

    2017-03-01

    Full Text Available Background: With the proportion of older adults in Europe expected to grow significantly over the next few decades, a number of pertinent questions are raised about the socio-spatial processes that underlie residential age segregation, especially in circumstances where it may be increasing. Objective: We present evidence on whether, and to what degree, residential age segregation has changed across neighbourhoods in England and Wales since the 1990s. Methods: We examine the residential patterns of older adults (aged 65 and over compared to those of younger adults (aged 25-40 for neighbourhoods across the country, for neighbourhoods within districts, and for neighbourhoods within districts classified by type. The analyses use harmonised population data for small areas (Output Areas from the 1991, 2001, and 2011 Censuses of England and Wales. Results: The results reveal increasing segregation over time (1991-2011 between older and younger groups across neighbourhoods nationally. Although the index values of segregation tend to be higher in less urban areas, highlighting a strong age and life course dimension of the rural-urban divide, a rapid increase in age segregation is found in urban areas. Moreover, our findings suggest the existence of convergent clusters of increasing age segregation, particularly in urban settings (from small to large cities and former industrial areas in the North of England, thus providing evidence suggesting a further dimension of the North-South divide. Conclusions: The findings demonstrate a growing age bifurcation over time and space, as both older and younger age groups are increasingly living apart. Although the drivers and consequences of these trends in residential age segregation remain unclear, the potential challenge to policies of social cohesion underlines the importance of further research. Contribution: The findings contribute to current debates about relations between age groups and generations in

  16. Epidemiology and trends for Caesarean section births in New South Wales, Australia: A population-based study

    Directory of Open Access Journals (Sweden)

    Morris Jonathan M

    2011-01-01

    Full Text Available Abstract Background Caesarean section (CS rates around the world have been increasing and in Australia have reached 30% of all births. Robson's Ten-Group Classification System (10-group classification provides a clinically relevant classification of CS rates that provides a useful basis for international comparisons and trend analyses. This study aimed to investigate trends in CS rates in New South Wales (NSW, including trends in the components of the 10-group classification. Methods We undertook a cross-sectional study using data from the Midwives Data Collection, a state-wide surveillance system that monitors patterns of pregnancy care, services and pregnancy outcomes in New South Wales, Australia. The study population included all women giving birth between 1st January 1998 and 31st December 2008. Descriptive statistics are presented including age-standardised CS rates, annual percentage change as well as regression analyses. Results From 1998 to 2008 the CS rate in NSW increased from 19.1 to 29.5 per 100 births. There was a significant average annual increase in primary 4.3% (95%CI 3.0-5.7% and repeat 4.8% (95% CI 3.9-5.7% CS rates from 1998 to 2008. After adjusting for maternal and pregnancy factors, the increase in CS delivery over time was maintained. When examining CS rates classified according to the 10-group classification, the greatest contributors to the overall CS rate and the largest annual increases occurred among nulliparae at term having elective CS and multipara having elective repeat CS. Conclusions Given that the increased CS rate cannot be explained by known and collected maternal or pregnancy characteristics, the increase may be related to differences in clinical decision making or maternal request. Future efforts to reduce the overall CS rate should be focussed on reducing the primary CS rate.

  17. Choice vs. voice? PPI policies and the re‐positioning of the state in England and Wales

    Science.gov (United States)

    Hughes, David; Mullen, Caroline; Vincent‐Jones, Peter

    2009-01-01

    Abstract Context and Thesis  Changing patient and public involvement (PPI) policies in England and Wales are analysed against the background of wider National Health Service (NHS) reforms and regulatory frameworks. We argue that the growing divergence of health policies is accompanied by a re‐positioning of the state vis‐à‐vis PPI, characterized by different mixes of centralized and decentralized regulatory instruments. Method  Analysis of legislation and official documents, and interviews with policy makers. Findings  In England, continued hierarchical control is combined with the delegation of responsibilities for the oversight and organization of PPI to external institutions such as the Care Quality Commission and local involvement networks, in support of the government’s policy agenda of increasing marketization. In Wales, which has rejected market reforms and economic regulation, decentralization is occurring through the use of mixed regulatory approaches and networks suited to the small‐country governance model, and seeks to benefit from the close proximity of central and local actors by creating new forms of engagement while maintaining central steering of service planning. Whereas English PPI policies have emerged in tandem with a pluralistic supply‐side market and combine new institutional arrangements for patient ‘choice’ with other forms of involvement, the Welsh policies focus on ‘voice’ within a largely publicly‐delivered service. Discussion  While the English reforms draw on theories of economic regulation and the experience of independent regulation in the utilities sector, the Welsh model of local service integration has been more influenced by reforms in local government. Such transfers of governance instruments from other public service sectors to the NHS may be problematic. PMID:19754688

  18. Choice vs. voice? PPI policies and the re-positioning of the state in England and Wales.

    Science.gov (United States)

    Hughes, David; Mullen, Caroline; Vincent-Jones, Peter

    2009-09-01

    CONTEXT AND THESIS: Changing patient and public involvement (PPI) policies in England and Wales are analysed against the background of wider National Health Service (NHS) reforms and regulatory frameworks. We argue that the growing divergence of health policies is accompanied by a re-positioning of the state vis-à-vis PPI, characterized by different mixes of centralized and decentralized regulatory instruments. Analysis of legislation and official documents, and interviews with policy makers. In England, continued hierarchical control is combined with the delegation of responsibilities for the oversight and organization of PPI to external institutions such as the Care Quality Commission and local involvement networks, in support of the government's policy agenda of increasing marketization. In Wales, which has rejected market reforms and economic regulation, decentralization is occurring through the use of mixed regulatory approaches and networks suited to the small-country governance model, and seeks to benefit from the close proximity of central and local actors by creating new forms of engagement while maintaining central steering of service planning. Whereas English PPI policies have emerged in tandem with a pluralistic supply-side market and combine new institutional arrangements for patient 'choice' with other forms of involvement, the Welsh policies focus on 'voice' within a largely publicly-delivered service. While the English reforms draw on theories of economic regulation and the experience of independent regulation in the utilities sector, the Welsh model of local service integration has been more influenced by reforms in local government. Such transfers of governance instruments from other public service sectors to the NHS may be problematic.

  19. Ocular and visual status among children in special schools in Wales: the burden of unrecognised visual impairment.

    Science.gov (United States)

    Woodhouse, J Margaret; Davies, Nathan; McAvinchey, Aideen; Ryan, Barbara

    2014-06-01

    The high prevalence of visual defects among children with special needs is well reported and guidelines for vision screening are in place. However, recent research has suggested that vision care for such children is neglected. This study set out to evaluate the current status of vision screening and eye care in special schools in Wales. In phase 1, all 44 special schools in Wales received a questionnaire on current vision screening practices. In phase 2, full eye examinations were conducted with 173 pupils of five schools with no screening service; the pupils were aged 2-21 years. In phase 3, feedback about the service was obtained from all schools and from 15 parents whose children took part. In phase 1, vision screening was patchy and inconsistent among the 39 schools responding. In phase 2, there is a high proportion of pupils (42%) reporting no previous eye examination. Overall, 17% of the pupils in the five schools presented with low vision (WHO definition, poorer than 0.3 LogMAR), 50% needed a first-time or updated spectacle prescription and 51% had some ocular abnormality that was either sight-limiting or warranted action to prevent risk to sight. In phase 3, school staff and parents reported that school-based eye examinations were valuable and, for those children with previous experience, likely to be more successful than clinic-based or practice-based examinations for this particular population. There is an urgent need for a school-based optometric service for this vulnerable group of children and young people. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  20. Prospects after Major Trauma

    NARCIS (Netherlands)

    Holtslag, H.R.

    2007-01-01

    Introduction. After patients survived major trauma, their prospects, in terms of the consequences for functioning, are uncertain, which may impact severely on patient, family and society. The studies in this thesis describes the long-term outcomes of severe injured patients after major trauma. In