Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers.

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Mathewos Tessema

Full Text Available Aberrant cytosine methylation affects regulation of hundreds of genes during cancer development. In this study, a novel aberrantly hypermethylated CpG island in cancer was discovered within the TOX2 promoter. TOX2 was unmethylated in normal cells but 28% lung (n = 190 and 23% breast (n = 80 tumors were methylated. Expression of two novel TOX2 transcripts identified was significantly reduced in primary lung tumors than distant normal lung (p<0.05. These transcripts were silenced in methylated lung and breast cancer cells and 5-Aza-2-deoxycytidine treatment re-expressed both. Extension of these assays to TOX, TOX3, and TOX4 genes that share similar genomic structure and protein homology with TOX2 revealed distinct methylation profiles by smoking status, histology, and cancer type. TOX was almost exclusively methylated in breast (43% than lung (5% cancer, whereas TOX3 was frequently methylated in lung (58% than breast (30% tumors. TOX4 was unmethylated in all samples and showed the highest expression in normal lung. Compared to TOX4, expression of TOX, TOX2 and TOX3 in normal lung was 25, 44, and 88% lower, respectively, supporting the premise that reduced promoter activity confers increased susceptibility to methylation during lung carcinogenesis. Genome-wide assays revealed that siRNA-mediated TOX2 knockdown modulated multiple pathways while TOX3 inactivation targeted neuronal development and function. Although these knockdowns did not result in further phenotypic changes of lung cancer cells in vitro, the impact on tissue remodeling, inflammatory response, and cell differentiation pathways suggest a potential role for TOX2 in modulating tumor microenvironment.

Understanding the Biology and Technology of ToxCast and Tox21 Assays

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The ToxCast high-throughput toxicity (HTT) testing methods have been developed to evaluate the hazard potential of diverse environmental, industrial and consumer product chemicals. The main goal is prioritizing the compounds of greatest concern for more detailed toxicological stu...

Applying network analysis and Nebula (neighbor-edges based and unbiased leverage algorithm) to ToxCast data.

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Ye, Hao; Luo, Heng; Ng, Hui Wen; Meehan, Joe; Ge, Weigong; Tong, Weida; Hong, Huixiao

2016-01-01

ToxCast data have been used to develop models for predicting in vivo toxicity. To predict the in vivo toxicity of a new chemical using a ToxCast data based model, its ToxCast bioactivity data are needed but not normally available. The capability of predicting ToxCast bioactivity data is necessary to fully utilize ToxCast data in the risk assessment of chemicals. We aimed to understand and elucidate the relationships between the chemicals and bioactivity data of the assays in ToxCast and to develop a network analysis based method for predicting ToxCast bioactivity data. We conducted modularity analysis on a quantitative network constructed from ToxCast data to explore the relationships between the assays and chemicals. We further developed Nebula (neighbor-edges based and unbiased leverage algorithm) for predicting ToxCast bioactivity data. Modularity analysis on the network constructed from ToxCast data yielded seven modules. Assays and chemicals in the seven modules were distinct. Leave-one-out cross-validation yielded a Q(2) of 0.5416, indicating ToxCast bioactivity data can be predicted by Nebula. Prediction domain analysis showed some types of ToxCast assay data could be more reliably predicted by Nebula than others. Network analysis is a promising approach to understand ToxCast data. Nebula is an effective algorithm for predicting ToxCast bioactivity data, helping fully utilize ToxCast data in the risk assessment of chemicals. Published by Elsevier Ltd.

Analysis of ToxCast data for food-relevant compounds by ...

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The ToxCast program has generated a wealth of in vitro high throughput screening data, and best approaches for the interpretation and use of these data remain undetermined. We present case studies comparing the ToxCast and in vivo toxicity data for two food contact substances using the RISK21 approach. Available exposure data, toxicity data, and model predictions were analyzed for sodium pyrithione and dibutyltin dichloride. In-vitro to in-vivo extrapolation (IVIVE) was performed to determine oral equivalent doses (OEDs) for the ToxCast data bioactivity. For sodium pyrithione, calculated OEDs corresponded to doses that demonstrated toxicity in animal studies. For dibutyltin dichloride, calculated OEDs were below the doses that demonstrated toxicity in animals, but this was confounded by the conservative estimates used in the IVIVE calculations. These studies highlight the potential of the ToxCast approach while also indicating areas where additional data or predictive tools are needed. We present case studies comparing the ToxCast and in vivo toxicity data for two food contact substances using the RISK21 approach.

ToxReporter: viewing the genome through the eyes of a toxicologist.

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Gosink, Mark

2016-01-01

One of the many roles of a toxicologist is to determine if an observed adverse event (AE) is related to a previously unrecognized function of a given gene/protein. Towards that end, he or she will search a variety of public and propriety databases for information linking that protein to the observed AE. However, these databases tend to present all available information about a protein, which can be overwhelming, limiting the ability to find information about the specific toxicity being investigated. ToxReporter compiles information from a broad selection of resources and limits display of the information to user-selected areas of interest. ToxReporter is a PERL-based web-application which utilizes a MySQL database to streamline this process by categorizing public and proprietary domain-derived information into predefined safety categories according to a customizable lexicon. Users can view gene information that is 'red-flagged' according to the safety issue under investigation. ToxReporter also uses a scoring system based on relative counts of the red-flags to rank all genes for the amount of information pertaining to each safety issue and to display their scored ranking as an easily interpretable 'Tox-At-A-Glance' chart. Although ToxReporter was originally developed to display safety information, its flexible design could easily be adapted to display disease information as well.Database URL: ToxReporter is freely available at https://github.com/mgosink/ToxReporter. © The Author(s) 2016. Published by Oxford University Press.

The Role of TOX in the Development of Innate Lymphoid Cells.

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Seehus, Corey R; Kaye, Jonathan

2015-01-01

TOX, an evolutionarily conserved member of the HMG-box family of proteins, is essential for the development of various cells of both the innate and adaptive immune system. TOX is required for the development of CD4(+) T lineage cells in the thymus, including natural killer T and T regulatory cells, as well as development of natural killer cells and fetal lymphoid tissue inducer cells, the latter required for lymph node organogenesis. Recently, we have identified a broader role for TOX in the innate immune system, demonstrating that this nuclear protein is required for generation of bone marrow progenitors that have potential to give rise to all innate lymphoid cells. Innate lymphoid cells, classified according to transcription factor expression and cytokine secretion profiles, derive from common lymphoid progenitors in the bone marrow and require Notch signals for their development. We discuss here the role of TOX in specifying CLP toward an innate lymphoid cell fate and hypothesize a possible role for TOX in regulating Notch gene targets during innate lymphoid cell development.

The Role of TOX in the Development of Innate Lymphoid Cells

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Corey R. Seehus

2015-01-01

Full Text Available TOX, an evolutionarily conserved member of the HMG-box family of proteins, is essential for the development of various cells of both the innate and adaptive immune system. TOX is required for the development of CD4+ T lineage cells in the thymus, including natural killer T and T regulatory cells, as well as development of natural killer cells and fetal lymphoid tissue inducer cells, the latter required for lymph node organogenesis. Recently, we have identified a broader role for TOX in the innate immune system, demonstrating that this nuclear protein is required for generation of bone marrow progenitors that have potential to give rise to all innate lymphoid cells. Innate lymphoid cells, classified according to transcription factor expression and cytokine secretion profiles, derive from common lymphoid progenitors in the bone marrow and require Notch signals for their development. We discuss here the role of TOX in specifying CLP toward an innate lymphoid cell fate and hypothesize a possible role for TOX in regulating Notch gene targets during innate lymphoid cell development.

TOX3 (TNRC9) overexpression in bladder cancer cells decreases cellular proliferation and triggers an interferon-like response

DEFF Research Database (Denmark)

Birkenkamp-Demtröder, Karin; Mansilla, Francisco; Andersen, Lars Dyrskjøt

2013-01-01

Background Human TOX3 (TOX high mobility group box family member 3) regulates Ca2+-dependent transcription in neurons and has been associated with breast cancer susceptibility. Aim of the study was to investigate the expression of TOX3 in bladder cancer tissue samples and to identify genes...... urothelium. Microarray expression profiling of human bladder cancer cells overexpressing TOX3 followed by Pathway analysis showed that TOX3 overexpression mainly affected the Interferon Signaling Pathway. TOX3 upregulation induced the expression of several genes with a gamma interferon activation site (GAS......), e.g. STAT1. In vitro functional studies showed that TOX3 was able to bind to the GAS-sequence located at the STAT1 promoter. siRNA mediated knockdown of TOX3 in RT4 bladder cancer cells decreased STAT1 expression suggesting a direct impact of TOX3 on STAT1. Immunoprecipitation of TOX3 overexpressing...

ToxCast Profiling in a Human Stem Cell Assay for ...

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Standard practice for assessing disruptions in embryogenesis involves testing pregnant animals of two species, typically rats and rabbits, exposed during major organogenesis and evaluated just prior to term. Under this design the major manifestations of developmental toxicity are observed as one or more apical endpoints including intrauterine death, fetal growth retardation, structural malformations and variations. Alternative approaches to traditional developmental toxicity testing have been proposed in the form of in vitro data (e.g., embryonic stem cells, zebrafish embryos, HTS assays) and in silico models (e.g., computational toxicology). To increase the diversity of assays used to assess developmental toxicity in EPA’s ToxCast program, we tested the chemicals in Stemina’s metabolomics-based platform that utilizes the commecrially available H9 human embryonic stem cell line. The devTOXqP dataset for ToxCast of high-quality based on replicate samples and model performance (82% balanced accuracy, 0.71 sensitivity and 1.00 specificity). To date, 136 ToxCast chemicals (12.8% of 1065 tested) were positive in this platform; 48 triggered the biomarker signal without any change in hESC viability and 88 triggered activity concurrent with effects on cell viability. Work is in progress to complete the STM dataset entry into the TCPL, compare data with results from zFish and mESC platforms, profile bioactivity (ToxCastDB), endpoints (ToxRefDB), chemotypes (DSSTox)

TOX3 (TNRC9) Over Expression in Bladder Cancer Cells Decreases Cellular Proliferation and Triggers an Interferon-Like Response

DEFF Research Database (Denmark)

Birkenkamp-Demtroder, Karin; Mansilla Castaño, Francisco; Dyrskjøt, Lars

2013-01-01

Background: Human TOX3 (TOX high mobility group box family member 3) regulates Ca2+ dependent transcription in neurons and has been associated with breast cancer susceptibility. Aim of the study was to investigate the expression of TOX3 in bladder cancer tissue samples and to identify genes...... urothelium. Microarray expression profiling of human bladder cancer cells over expressing TOX3 followed by Pathway analysis showed that TOX3 Overexpression mainly affected the Interferon Signaling Pathway. TOX3 up regulation induced the expression of several genes with a gamma interferon activation site (GAS......), e.g. STAT1. In vitro functional studies showed that TOX3 was able to bind to the GAS-sequence located at the STAT1 promoter. siRNA mediated knockdown of TOX3 in RT4 bladder cancer cells decreased STAT1 expression suggesting a direct impact of TOX3 on STAT1. Immunoprecipitation of TOX3 over...

CompTox Chemistry Dashboard webinar

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The CompTox Chemistry Dashboard is part of a suite of dashboards developed by EPA to help evaluate the safety of chemicals. The dashboard provides access to a variety of information on over 700,000 chemicals currently in use. Within the application, users

Chemical and HTS Profiling of 63 Cleft Palate Teratogens from ToxCast (FutureTox III)

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Cleft palate is a common human birth defect that has been linked to both genetic and environmental factors. To characterize the potential molecular targets and biological processes across mechanistically diverse teratogens that cause cleft palate, we mined the ToxCast high-throug...

Immunogenicity of fractional doses of tetravalent a/c/y/w135 meningococcal polysaccharide vaccine: results from a randomized non-inferiority controlled trial in Uganda.

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Philippe J Guerin

Full Text Available Neisseria meningitidis serogroup A is the main causative pathogen of meningitis epidemics in sub-Saharan Africa. In recent years, serogroup W135 has also been the cause of epidemics. Mass vaccination campaigns with polysaccharide vaccines are key elements in controlling these epidemics. Facing global vaccine shortage, we explored the use of fractional doses of a licensed A/C/Y/W135 polysaccharide meningococcal vaccine.We conducted a randomized, non-inferiority trial in 750 healthy volunteers 2-19 years old in Mbarara, Uganda, to compare the immune response of the full dose of the vaccine versus fractional doses (1/5 or 1/10. Safety and tolerability data were collected for all subjects during the 4 weeks following the injection. Pre- and post-vaccination sera were analyzed by measuring serum bactericidal activity (SBA with baby rabbit complement. A responder was defined as a subject with a > or =4-fold increase in SBA against a target strain from each serogroup and SBA titer > or =128. For serogroup W135, 94% and 97% of the vaccinees in the 1/5- and 1/10-dose arms, respectively, were responders, versus 94% in the full-dose arm; for serogroup A, 92% and 88% were responders, respectively, versus 95%. Non-inferiority was demonstrated between the full dose and both fractional doses in SBA seroresponse against serogroups W135 and Y, in total population analysis. Non-inferiority was shown between the full and 1/5 doses for serogroup A in the population non-immune prior to vaccination. Non-inferiority was not shown for any of the fractionate doses for serogroup C. Safety and tolerability data were favourable, as observed in other studies.While the advent of conjugate A vaccine is anticipated to largely contribute to control serogroup A outbreaks in Africa, the scale-up of its production will not cover the entire "Meningitis Belt" target population for at least the next 3 to 5 years. In view of the current shortage of meningococcal vaccines for Africa

20180416 - Understanding the Biology and Technology of ToxCast and Tox21 Assays (SETAC Durham NC)

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The ToxCast high-throughput toxicity (HTT) testing methods have been developed to evaluate the hazard potential of diverse environmental, industrial and consumer product chemicals. The main goal is prioritizing the compounds of greatest concern for more detailed toxicological stu...

Total Petroleum Hydrocarbons (TPH): ToxFAQs

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... a state: This map displays locations where Total Petroleum Hydrocarbons (TPH) is known to be present. On ... I get more information? ToxFAQs TM for Total Petroleum Hydrocarbons (TPH) ( Hidrocarburos Totales de Petróleo (TPH) ) August ...

The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality.

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Attene-Ramos, Matias S; Miller, Nicole; Huang, Ruili; Michael, Sam; Itkin, Misha; Kavlock, Robert J; Austin, Christopher P; Shinn, Paul; Simeonov, Anton; Tice, Raymond R; Xia, Menghang

2013-08-01

Since its establishment in 2008, the US Tox21 inter-agency collaboration has made great progress in developing and evaluating cellular models for the evaluation of environmental chemicals as a proof of principle. Currently, the program has entered its production phase (Tox21 Phase II) focusing initially on the areas of modulation of nuclear receptors and stress response pathways. During Tox21 Phase II, the set of chemicals to be tested has been expanded to nearly 10,000 (10K) compounds and a fully automated screening platform has been implemented. The Tox21 robotic system combined with informatics efforts is capable of screening and profiling the collection of 10K environmental chemicals in triplicate in a week. In this article, we describe the Tox21 screening process, compound library preparation, data processing, and robotic system validation. Published by Elsevier Ltd.

Creation and investigation of powerful EUV sources (λ ∼ 13.5 nm)

International Nuclear Information System (INIS)

Borisov, V. M.; Borisova, G. N.; Vinokhodov, A. Yu.; Ivanov, A. S.; Kiryukhin, Yu. B.; Mishchenko, V. A.; Prokofiev, A. V.; Khristoforov, O. B.

2010-01-01

Results are presented from experimental studies of repetitively pulsed EUV (λ = 13.5 ± 0.135 nm) sources based on a laser-initiated discharge in tin vapor between rotating disk electrodes. Radiative characteristics of two sources with different systems of tin supply onto the electrode surface and different types of power supply have been compared. A number of new effects have been revealed at pulse repetition rates as high as ∼4000 Hz. A mean radiation power of 520 W into the 2π solid angle has been achieved in the spectral band 13.5 ± 0.135 nm at a deposited electrical power of 24 kW.

Creation and investigation of powerful EUV sources (λ ≈ 13.5 nm)

Science.gov (United States)

Borisov, V. M.; Borisova, G. N.; Vinokhodov, A. Yu.; Ivanov, A. S.; Kiryukhin, Yu. B.; Mishchenko, V. A.; Prokofiev, A. V.; Khristoforov, O. B.

2010-03-01

Results are presented from experimental studies of repetitively pulsed EUV (λ = 13.5 ± 0.135 nm) sources based on a laser-initiated discharge in tin vapor between rotating disk electrodes. Radiative characteristics of two sources with different systems of tin supply onto the electrode surface and different types of power supply have been compared. A number of new effects have been revealed at pulse repetition rates as high as ˜4000 Hz. A mean radiation power of 520 W into the 2π solid angle has been achieved in the spectral band 13.5 ± 0.135 nm at a deposited electrical power of 24 kW.

Chemical Function Predictions for Tox21 Chemicals

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U.S. Environmental Protection Agency — Random forest chemical function predictions for Tox21 chemicals in personal care products uses and "other" uses. This dataset is associated with the following...

In silico ADME-Tox modeling: progress and prospects.

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Alqahtani, Saeed

2017-11-01

Although significant progress has been made in high-throughput screening of absorption, distribution, metabolism and excretion, and toxicity (ADME-Tox) properties in drug discovery and development, in silico ADME-Tox prediction continues to play an important role in facilitating the appropriate selection of candidate drugs by pharmaceutical companies prior to expensive clinical trials. Areas covered: This review provides an overview of the available in silico models that have been used to predict the ADME-Tox properties of compounds. It also provides a comprehensive overview and summarization of the latest modeling methods and algorithms available for the prediction of physicochemical characteristics, ADME properties, and drug toxicity issues. Expert opinion: The in silico models currently available have greatly contributed to the knowledge of screening approaches in the early stages of drug discovery and the development process. As the definitive goal of in silico molding is to predict the pharmacokinetics and disposition of compounds in vivo by assembling all kinetic processes within one global model, PBPK models can serve this purpose. However, much work remains to be done in this area to generate more data and input parameters to build more reliable and accurate prediction models.

ToxCast Workflow: High-throughput screening assay data processing, analysis and management (SOT)

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US EPA’s ToxCast program is generating data in high-throughput screening (HTS) and high-content screening (HCS) assays for thousands of environmental chemicals, for use in developing predictive toxicity models. Currently the ToxCast screening program includes over 1800 unique c...

AMBIT RESTful web services: an implementation of the OpenTox application programming interface

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Jeliazkova Nina

2011-05-01

Full Text Available Abstract The AMBIT web services package is one of the several existing independent implementations of the OpenTox Application Programming Interface and is built according to the principles of the Representational State Transfer (REST architecture. The Open Source Predictive Toxicology Framework, developed by the partners in the EC FP7 OpenTox project, aims at providing a unified access to toxicity data and predictive models, as well as validation procedures. This is achieved by i an information model, based on a common OWL-DL ontology ii links to related ontologies; iii data and algorithms, available through a standardized REST web services interface, where every compound, data set or predictive method has a unique web address, used to retrieve its Resource Description Framework (RDF representation, or initiate the associated calculations. The AMBIT web services package has been developed as an extension of AMBIT modules, adding the ability to create (Quantitative Structure-Activity Relationship (QSAR models and providing an OpenTox API compliant interface. The representation of data and processing resources in W3C Resource Description Framework facilitates integrating the resources as Linked Data. By uploading datasets with chemical structures and arbitrary set of properties, they become automatically available online in several formats. The services provide unified interfaces to several descriptor calculation, machine learning and similarity searching algorithms, as well as to applicability domain and toxicity prediction models. All Toxtree modules for predicting the toxicological hazard of chemical compounds are also integrated within this package. The complexity and diversity of the processing is reduced to the simple paradigm "read data from a web address, perform processing, write to a web address". The online service allows to easily run predictions, without installing any software, as well to share online datasets and models. The

AMBIT RESTful web services: an implementation of the OpenTox application programming interface.

Science.gov (United States)

Jeliazkova, Nina; Jeliazkov, Vedrin

2011-05-16

The AMBIT web services package is one of the several existing independent implementations of the OpenTox Application Programming Interface and is built according to the principles of the Representational State Transfer (REST) architecture. The Open Source Predictive Toxicology Framework, developed by the partners in the EC FP7 OpenTox project, aims at providing a unified access to toxicity data and predictive models, as well as validation procedures. This is achieved by i) an information model, based on a common OWL-DL ontology ii) links to related ontologies; iii) data and algorithms, available through a standardized REST web services interface, where every compound, data set or predictive method has a unique web address, used to retrieve its Resource Description Framework (RDF) representation, or initiate the associated calculations.The AMBIT web services package has been developed as an extension of AMBIT modules, adding the ability to create (Quantitative) Structure-Activity Relationship (QSAR) models and providing an OpenTox API compliant interface. The representation of data and processing resources in W3C Resource Description Framework facilitates integrating the resources as Linked Data. By uploading datasets with chemical structures and arbitrary set of properties, they become automatically available online in several formats. The services provide unified interfaces to several descriptor calculation, machine learning and similarity searching algorithms, as well as to applicability domain and toxicity prediction models. All Toxtree modules for predicting the toxicological hazard of chemical compounds are also integrated within this package. The complexity and diversity of the processing is reduced to the simple paradigm "read data from a web address, perform processing, write to a web address". The online service allows to easily run predictions, without installing any software, as well to share online datasets and models. The downloadable web application

The cysteine rich necrotrophic effector SnTox1 produced by Stagonospora nodorum triggers susceptibility of wheat lines harboring Snn1.

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Zhaohui Liu

2012-01-01

Full Text Available The wheat pathogen Stagonospora nodorum produces multiple necrotrophic effectors (also called host-selective toxins that promote disease by interacting with corresponding host sensitivity gene products. SnTox1 was the first necrotrophic effector identified in S. nodorum, and was shown to induce necrosis on wheat lines carrying Snn1. Here, we report the molecular cloning and validation of SnTox1 as well as the preliminary characterization of the mechanism underlying the SnTox1-Snn1 interaction which leads to susceptibility. SnTox1 was identified using bioinformatics tools and verified by heterologous expression in Pichia pastoris. SnTox1 encodes a 117 amino acid protein with the first 17 amino acids predicted as a signal peptide, and strikingly, the mature protein contains 16 cysteine residues, a common feature for some avirulence effectors. The transformation of SnTox1 into an avirulent S. nodorum isolate was sufficient to make the strain pathogenic. Additionally, the deletion of SnTox1 in virulent isolates rendered the SnTox1 mutated strains avirulent on the Snn1 differential wheat line. SnTox1 was present in 85% of a global collection of S. nodorum isolates. We identified a total of 11 protein isoforms and found evidence for strong diversifying selection operating on SnTox1. The SnTox1-Snn1 interaction results in an oxidative burst, DNA laddering, and pathogenesis related (PR gene expression, all hallmarks of a defense response. In the absence of light, the development of SnTox1-induced necrosis and disease symptoms were completely blocked. By comparing the infection processes of a GFP-tagged avirulent isolate and the same isolate transformed with SnTox1, we conclude that SnTox1 may play a critical role during fungal penetration. This research further demonstrates that necrotrophic fungal pathogens utilize small effector proteins to exploit plant resistance pathways for their colonization, which provides important insights into the molecular

20180312 - Profiling the ToxCast library with a pluripotent human (H9) embryonic stem cell assay (SOT)

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The Stemina devTOX quickPredict platform (STM) is a human pluripotent H9 stem cell-based assay that predicts developmental toxicants. Using the STM model, we screened 1065 ToxCast chemicals and entered the data into the ToxCast data analysis pipeline. Model performance was 83.3% ...

FutureTox III: Bridges for Translation

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The present document describes key discussion points and outcomes of a Society of Toxicology (SOT) Contemporary Concepts in Toxicology (CCT) Workshop, entitled FutureTox III1,2 that was held in Crystal City, Virginia, November 19-20, 2015. The workshop built on the many lessons l...

“httk”: EPA’s Tool for High Throughput Toxicokinetics (CompTox CoP)

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Thousands of chemicals have been pro?led by high-throughput screening programs such as ToxCast and Tox21; these chemicals are tested in part because most of them have limited or no data on hazard, exposure, or toxicokinetics. Toxicokinetic models aid in predicting tissue concentr...

Intracranial contrast transit times on digital subtraction angiography decrease more in patients with delayed intraparenchymal hemorrhage after Pipeline.

Science.gov (United States)

Brunozzi, Denise; Shakur, Sophia F; Charbel, Fady T; Alaraj, Ali

2018-04-01

Background Pipeline embolization devices (PEDs) are used for endovascular treatment of cerebral aneurysms but can be associated with delayed ipsilateral intraparenchymal hemorrhage (DIPH). Changes in intracranial hemodynamics after PED are poorly understood. Objective Here, we assess hemodynamic changes after PED in patients and compare these changes in patients with and without DIPH (DIPH+ and DIPH-). Methods Records of patients with distal internal carotid artery (ICA) aneurysms treated with PED at our institution between 2012 and 2017 were retrospectively reviewed. Regions of interest were selected proximally to PED over the cavernous ICA and distally over the middle cerebral artery (MCA), and then transit times were determined using syngo iFlow software (Siemens). Ratio of MCA to ICA transit time was compared before, after treatment, and at follow-up. Ratios were also compared between DIPH+ and DIPH- subgroups. Correlations between aneurysm size, age, and ratios were investigated. Results Fifty-three patients were included. The ratio of MCA to ICA transit time decreased significantly after PED deployment (1.13 vs. 1.22, p transit time decreases following PED treatment and decreases more in patients with DIPH. These contrast transit time changes can be detected in real time immediately after PED deployment.

ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models.

Science.gov (United States)

Marvel, Skylar W; To, Kimberly; Grimm, Fabian A; Wright, Fred A; Rusyn, Ivan; Reif, David M

2018-03-05

Drawing integrated conclusions from diverse source data requires synthesis across multiple types of information. The ToxPi (Toxicological Prioritization Index) is an analytical framework that was developed to enable integration of multiple sources of evidence by transforming data into integrated, visual profiles. Methodological improvements have advanced ToxPi and expanded its applicability, necessitating a new, consolidated software platform to provide functionality, while preserving flexibility for future updates. We detail the implementation of a new graphical user interface for ToxPi (Toxicological Prioritization Index) that provides interactive visualization, analysis, reporting, and portability. The interface is deployed as a stand-alone, platform-independent Java application, with a modular design to accommodate inclusion of future analytics. The new ToxPi interface introduces several features, from flexible data import formats (including legacy formats that permit backward compatibility) to similarity-based clustering to options for high-resolution graphical output. We present the new ToxPi interface for dynamic exploration, visualization, and sharing of integrated data models. The ToxPi interface is freely-available as a single compressed download that includes the main Java executable, all libraries, example data files, and a complete user manual from http://toxpi.org .

Effect of toxin-g from Tityus serrulatus scorpion venom on gastric emptying in rats

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F. Bucaretchi

1999-04-01

Full Text Available The effect of toxin-g from Tityus serrulatus scorpion venom on the gastric emptying of liquids was studied in 176 young adult male Wistar rats (2-3 months of age divided into subgroups of 8 animals each. Toxin-g was injected iv at doses of 25, 37.5, 50 or 100 µg/kg and the effect on gastric emptying was assessed 30 min and 8 h later. A time-course study was also performed by injecting 50 µg of toxin-g /kg and measuring the effect on gastric emptying at times 0.25, 0.5, 1, 2, 4, 8, 24 and 48 h post-venom. Each envenomed animal was paired with its saline control and all received a saline test meal solution containing phenol red (60 µg/ml as a marker. Ten minutes after administering the test meal by gavage the animals were sacrificed and gastric retention was determined by measuring the residual marker concentration of the test meal. A significant delay in gastric emptying, at 30 min and 8 h post-venom, was observed only after 50 and 100 µg of toxin-g /kg compared to control values. The responses to these two doses were significantly different after 8 h post-venom. Toxin-g (50 µg/kg significantly delayed the gastric emptying of liquids at all times studied, with a peak response at 4 h after toxin administration compared to control values. These results indicate that the iv injection of toxin-g may induce a rapid, intense and sustained inhibition of gastric emptying 0.25 to 48 h after envenomation.

CBirTox is a selective antigen-specific agonist of the Treg-IgA-microbiota homeostatic pathway.

Directory of Open Access Journals (Sweden)

Katie L Alexander

Full Text Available Cultivating an environment of mutualism between host cells and the microbiota is vital, and dysregulation of this relationship is associated with multiple immune disorders including metabolic and skin diseases, asthma, allergy, and Inflammatory Bowel Disease (IBD. One prominent mechanism for maintaining homeostasis is the protective regulatory T cell (Treg- Immunoglobulin A (IgA pathway toward microbiota antigens, in which Tregs maintain homeostasis and provide critical survival factors to IgA+ B cells. In order to amplify the Treg-IgA pathway, we have generated a fusion protein, CBirTox, comprised of a portion of the carboxy terminus of CBir1, a microbiota flagellin, genetically coupled to Cholera Toxin B subunit (CTB via the A2 linker of CT. Both dendritic cells (DCs and B cells pulsed with CBirTox selectively induced functional CD4+Foxp3+ Tregs in vitro, and CBirTox augmented CD4+Foxp3+ cell numbers in vivo. The induced Foxp3 expression was independent of retinoic acid (RA signaling but was inhibited by neutralization of TGF-β. CBirTox treatment of B cells downregulated mammalian target of rapamycin (mTOR signaling. Furthermore, CBirTox-pulsed DCs induced substantial production of IgA from naïve B cells. Collectively these data demonstrate that CBirTox represents a novel approach to bolstering the Treg-IgA pathway at the host-microbiota interface.

ProTox: a web server for the in silico prediction of rodent oral toxicity.

Science.gov (United States)

Drwal, Malgorzata N; Banerjee, Priyanka; Dunkel, Mathias; Wettig, Martin R; Preissner, Robert

2014-07-01

Animal trials are currently the major method for determining the possible toxic effects of drug candidates and cosmetics. In silico prediction methods represent an alternative approach and aim to rationalize the preclinical drug development, thus enabling the reduction of the associated time, costs and animal experiments. Here, we present ProTox, a web server for the prediction of rodent oral toxicity. The prediction method is based on the analysis of the similarity of compounds with known median lethal doses (LD50) and incorporates the identification of toxic fragments, therefore representing a novel approach in toxicity prediction. In addition, the web server includes an indication of possible toxicity targets which is based on an in-house collection of protein-ligand-based pharmacophore models ('toxicophores') for targets associated with adverse drug reactions. The ProTox web server is open to all users and can be accessed without registration at: http://tox.charite.de/tox. The only requirement for the prediction is the two-dimensional structure of the input compounds. All ProTox methods have been evaluated based on a diverse external validation set and displayed strong performance (sensitivity, specificity and precision of 76, 95 and 75%, respectively) and superiority over other toxicity prediction tools, indicating their possible applicability for other compound classes. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

TOX sets the stage for innate lymphoid cells

NARCIS (Netherlands)

Spits, Hergen

2015-01-01

Like T cells and B cells, innate lymphoid cells (ILCs) develop from common lymphoid progenitors, but how commitment to the ILC lineage is regulated has remained unclear. The transcriptional regulator TOX is important in this process

Toxicology in the 21st Century (Tox21)

Science.gov (United States)

Tox21 researchers aim to develop better toxicity assessment methods to quickly and efficiently test whether certain chemical compounds have the potential to disrupt processes in the human body that may lead to negative health effects.

INTERACTION OF LASER RADIATION WITH MATTER. LASER PLASMA High-power EUV (13.5 nm) light source

Science.gov (United States)

Borisov, Vladimir M.; Borisova, Galina N.; Vinokhodov, Aleksandr Yu; Zakharov, S. V.; Ivanov, Aleksandr S.; Kiryukhin, Yurii B.; Mishchenko, Valentin A.; Prokof'ev, Aleksandr V.; Khristoforov, Oleg B.

2010-10-01

Characteristics of a discharge-produced plasma (DPP) light source in the spectral band 13.5±0.135 nm, developed for Extreme Ultra Violet (EUV) lithography, are presented. EUV light is generated by DPP in tin vapour formed between rotating disk electrodes. The discharge is ignited by a focused laser beam. The EUV power 1000 W/(2π sr) in the spectral band 13.5±0.135 nm was achieved with input power about of ~63 kW to the plasma at a pulse repetition rate ~7 kHz . The results of numerical simulation are compared with the experimental data.

Cheminformatics Analysis of EPA ToxCast Chemical Libraries ...

Science.gov (United States)

An important goal of toxicology research is the development of robust methods that use in vitro and chemical structure information to predict in vivo toxicity endpoints. The US EPA ToxCast program is addressing this goal using ~600 in vitro assays to create bioactivity profiles on a set of 320 compounds, mostly pesticide actives, that have well characterized in vivo toxicity. These 320 compounds (EPA-320 set evaluated in Phase I of ToxCast) are a subset of a much larger set of ~10,000 candidates that are of interest to the EPA (called here EPA-10K). Predictive models of in vivo toxicity are being constructed from the in vitro assay data on the EPA-320 chemical set. These models require validation on additional chemicals prior to wide acceptance, and this will be carried out by evaluating compounds from EPA-10K in Phase II of ToxCast. We have used cheminformatics approaches including clustering, data visualization, and QSAR to develop models for EPA-320 that could help prioritizing EPA-10K validation chemicals. Both chemical descriptors, as well as calculated physicochemical properties have been used. Compounds from EPA-10K are prioritized based on their similarity to EPA-320 using different similarity metrics, with similarity thresholds defining the domain of applicability for the predictive models built for EPA-320 set. In addition, prioritized lists of compounds of increasing dissimilarity from the EPA-320 have been produced, to test the ability of the EPA-320

TOXsIgN: a cross-species repository for toxicogenomic signatures.

Science.gov (United States)

Darde, Thomas A; Gaudriault, Pierre; Beranger, Rémi; Lancien, Clément; Caillarec-Joly, Annaëlle; Sallou, Olivier; Bonvallot, Nathalie; Chevrier, Cécile; Mazaud-Guittot, Séverine; Jégou, Bernard; Collin, Olivier; Becker, Emmanuelle; Rolland, Antoine D; Chalmel, Frédéric

2018-01-27

At the same time that toxicologists express increasing concern about reproducibility in this field, the development of dedicated databases has already smoothed the path toward improving the storage and exchange of raw toxicogenomic data. Nevertheless, none provides access to analyzed and interpreted data as originally reported in scientific publications. Given the increasing demand for access to this information, we developed TOXsIgN, a repository for TOXicogenomic sIgNatures. The TOXsIgN repository provides a flexible environment that facilitates online submission, storage, and retrieval of toxicogenomic signatures by the scientific community. It currently hosts 754 projects that describe more than 450 distinct chemicals and their 8491 associated signatures. It also provides users with a working environment containing a powerful search engine as well as bioinformatics/biostatistics modules that enable signature comparisons or enrichment analyses. The TOXsIgN repository is freely accessible at http://toxsign.genouest.org. Website implemented in Python, JavaScript, and MongoDB, with all major browsers supported. frederic.chalmel@inserm.fr. Supplementary data are available at Bioinformatics online. © The Author (2018). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

Tutorial Video Series: Using Stakeholder Outreach to Increase Usage of ToxCast Data (SETAC EU)

Science.gov (United States)

The limited amount of toxicity data on thousands of chemicals found in consumer products has led to the development of research endeavors such as the U.S. EPA’s Toxicity Forecaster (ToxCast). ToxCast uses high-throughput screening technology to evaluate thousands of chemicals for...

Intersection of toxicogenomics and high throughput screening in the Tox21 program: an NIEHS perspective.

Science.gov (United States)

Merrick, B Alex; Paules, Richard S; Tice, Raymond R

Humans are exposed to thousands of chemicals with inadequate toxicological data. Advances in computational toxicology, robotic high throughput screening (HTS), and genome-wide expression have been integrated into the Tox21 program to better predict the toxicological effects of chemicals. Tox21 is a collaboration among US government agencies initiated in 2008 that aims to shift chemical hazard assessment from traditional animal toxicology to target-specific, mechanism-based, biological observations using in vitro assays and lower organism models. HTS uses biocomputational methods for probing thousands of chemicals in in vitro assays for gene-pathway response patterns predictive of adverse human health outcomes. In 1999, NIEHS began exploring the application of toxicogenomics to toxicology and recent advances in NextGen sequencing should greatly enhance the biological content obtained from HTS platforms. We foresee an intersection of new technologies in toxicogenomics and HTS as an innovative development in Tox21. Tox21 goals, priorities, progress, and challenges will be reviewed.

Predicting Developmental Toxicity of ToxCast Phase I Chemicals Using Human Embryonic Stem Cells and Metabolomics

Science.gov (United States)

EPA’s ToxRefDB contains prenatal guideline study data from rats and rabbits for over 240 chemicals that overlap with the ToxCast in vitro high throughput screening project. A subset of these compounds were tested in Stemina Biomarker Discovery's developmental toxicity platform, a...

Metabolism Retrofit Strategies for ToxCast Assays (BOSC)

Science.gov (United States)

The EPA’s ToxCast program utilizes a wide variety of high-throughput screening assays (HTS) to assess chemical perturbations of molecular and cellular endpoints. A limitation of many HTS assays used for toxicity assessment is the lack of xenobiotic metabolism (XM) which precludes...

Proteolysis of virulence regulator ToxR is associated with entry of Vibrio cholerae into a dormant state.

Directory of Open Access Journals (Sweden)

Salvador Almagro-Moreno

2015-04-01

Full Text Available Vibrio cholerae O1 is a natural inhabitant of aquatic environments and causes the diarrheal disease, cholera. Two of its primary virulence regulators, TcpP and ToxR, are localized in the inner membrane. TcpP is encoded on the Vibrio Pathogenicity Island (VPI, a horizontally acquired mobile genetic element, and functions primarily in virulence gene regulation. TcpP has been shown to undergo regulated intramembrane proteolysis (RIP in response to environmental conditions that are unfavorable for virulence gene expression. ToxR is encoded in the ancestral genome and is present in non-pathogenic strains of V. cholerae, indicating it has roles outside of the human host. In this study, we show that ToxR undergoes RIP in V. cholerae in response to nutrient limitation at alkaline pH, a condition that occurs during the stationary phase of growth. This process involves the site-2 protease RseP (YaeL, and is dependent upon the RpoE-mediated periplasmic stress response, as deletion mutants for the genes encoding these two proteins cannot proteolyze ToxR under nutrient limitation at alkaline pH. We determined that the loss of ToxR, genetically or by proteolysis, is associated with entry of V. cholerae into a dormant state in which the bacterium is normally found in the aquatic environment called viable but nonculturable (VBNC. Strains that can proteolyze ToxR, or do not encode it, lose culturability, experience a change in morphology associated with cells in VBNC, yet remain viable under nutrient limitation at alkaline pH. On the other hand, mutant strains that cannot proteolyze ToxR remain culturable and maintain the morphology of cells in an active state of growth. Overall, our findings provide a link between the proteolysis of a virulence regulator and the entry of a pathogen into an environmentally persistent state.

Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk.

Science.gov (United States)

Daneshian, Mardas; Kamp, Hennicke; Hengstler, Jan; Leist, Marcel; van de Water, Bob

2016-05-01

The integrated European project, EU-ToxRisk, proudly sees itself as "flagship" exploring new alternative-to-animal approaches to chemical safety evaluation. It promotes mechanism-based toxicity testing and risk assessment according to the principles laid down for toxicology for the twenty-first century. The project was officially launched in January 2016 with a kickoff meeting in Egmond aan Zee, the Netherlands. Over 100 scientists representing academia and industry as well as regulatory authorities attended the inaugural meeting. The project will integrate advances in in vitro and in silico toxicology, read-across methods, and adverse outcome pathways. EU-ToxRisk will continue to make use of the case study strategy deployed in SEURAT-1, a FP7 initiative ended in December 2015. Even though the development of new non-animal methods is one target of EU-ToxRisk, the project puts special emphasis on their acceptance and implementation in regulatory contexts. This €30 million Horizon 2020 project involves 38 European partners and one from the USA. EU-ToxRisk aims at the "development of a new way of risk assessment."

Toxicology Testing in the 21st Century (Tox21)

Science.gov (United States)

Tox21 researchers aim to develop better toxicity assessment methods to quickly and efficiently test whether certain chemical compounds have the potential to disrupt processes in the human body that may lead to negative health effects.

The ToxBank Data Warehouse: Supporting the Replacement of In Vivo Repeated Dose Systemic Toxicity Testing.

Science.gov (United States)

Kohonen, Pekka; Benfenati, Emilio; Bower, David; Ceder, Rebecca; Crump, Michael; Cross, Kevin; Grafström, Roland C; Healy, Lyn; Helma, Christoph; Jeliazkova, Nina; Jeliazkov, Vedrin; Maggioni, Silvia; Miller, Scott; Myatt, Glenn; Rautenberg, Michael; Stacey, Glyn; Willighagen, Egon; Wiseman, Jeff; Hardy, Barry

2013-01-01

The aim of the SEURAT-1 (Safety Evaluation Ultimately Replacing Animal Testing-1) research cluster, comprised of seven EU FP7 Health projects co-financed by Cosmetics Europe, is to generate a proof-of-concept to show how the latest technologies, systems toxicology and toxicogenomics can be combined to deliver a test replacement for repeated dose systemic toxicity testing on animals. The SEURAT-1 strategy is to adopt a mode-of-action framework to describe repeated dose toxicity, combining in vitro and in silico methods to derive predictions of in vivo toxicity responses. ToxBank is the cross-cluster infrastructure project whose activities include the development of a data warehouse to provide a web-accessible shared repository of research data and protocols, a physical compounds repository, reference or "gold compounds" for use across the cluster (available via wiki.toxbank.net), and a reference resource for biomaterials. Core technologies used in the data warehouse include the ISA-Tab universal data exchange format, REpresentational State Transfer (REST) web services, the W3C Resource Description Framework (RDF) and the OpenTox standards. We describe the design of the data warehouse based on cluster requirements, the implementation based on open standards, and finally the underlying concepts and initial results of a data analysis utilizing public data related to the gold compounds. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

An Evaluation of ToxCast Angiogenic Disruptors for Effects on Mitochondrial Bioactivity Profiles (Teratology Society Annual Meeting)

Science.gov (United States)

Angiogenesis is a critical developmental process and a potential target for chemical teratogenesis. Over one-tenth of the Tox21 library of 10,000 compounds have been shown to disrupt mitochondrial function [Attene-Ramos et al., 2015]. Previous studies utilizing ToxCast chemicals ...

Deiodinase 1 Screening of ToxCast Phase 1 Chemical Library

Data.gov (United States)

U.S. Environmental Protection Agency — This excel spreadsheet contains the resultant data for over from inhibition assays with human Deiodinase 1 screened against the ToxCast Phase 1 chemical library and...

Structure Identification Using High Resolution Mass Spectrometry Data and the EPA’s CompTox Chemistry Dashboard (EAS)

Science.gov (United States)

The iCSS CompTox Dashboard is a publicly accessible dashboard provided by the National Center for Computation Toxicology at the US-EPA. It serves a number of purposes, including providing a chemistry database underpinning many of our public-facing projects (e.g. ToxCast and ExpoC...

Extending the Derek-Meteor Workflow to Predict Chemical-Toxicity Space Impacted by Metabolism: Application to ToxCast and Tox21 Chemical Inventories

Science.gov (United States)

A central aim of EPA’s ToxCast project is to use in vitro high-throughput screening (HTS) profiles to build predictive models of in vivo toxicity. Where assays lack metabolic capability, such efforts may need to anticipate the role of metabolic activation (or deactivation). A wo...

Development of a toxR-based loop-mediated isothermal amplification assay for detecting Vibrio parahaemolyticus

Directory of Open Access Journals (Sweden)

Ge Beilei

2010-02-01

Full Text Available Abstract Background Vibrio parahaemolyticus is a leading cause of seafood-related bacterial gastroenteritis and outbreaks worldwide. Sensitive and specific detection methods are needed to better control V. parahaemolyticus infections. This study aimed at developing a highly specific and sensitive loop-mediated isothermal amplification (LAMP assay for detecting V. parahaemolyticus in oysters. A set of five LAMP primers, two outer, two inner, and one loop were designed based on the published V. parahaemolyticus toxR sequence. Specificity of the assay was evaluated using a panel of 36 V. parahaemolyticus and 39 other strains. The assay sensitivity was determined using serial dilutions of V. parahaemolyticus ATCC 27969 culture ranging from 108 CFU/ml to extinction. The assay was also tested in experimentally inoculated oyster samples. Results The toxR-based LAMP assay was able to specifically detect all of the 36 V. parahaemolyticus strains without amplification from 39 other strains. The detection limit was 47-470 cells per reaction in pure culture, up to 100-fold more sensitive than that of toxR-PCR. When applied in spiked oysters, the assay was able to detect 1.1 × 105 V. parahaemolyticus cells per gram of oyster without enrichment, up to 100-fold more sensitive than that of toxR-PCR. Standard curves generated for detecting V. parahaemolyticus in both pure culture and spiked oyster samples showed good linear relationship between cell numbers and the fluorescence or turbidity signals. Conclusions The toxR-based LAMP assay developed in this study was sensitive, specific, and quantitative, holding great potential for future field detection of V. parahaemolyticus in raw oysters.

Value of shared preclinical safety studies - The eTOX database.

Science.gov (United States)

Briggs, Katharine; Barber, Chris; Cases, Montserrat; Marc, Philippe; Steger-Hartmann, Thomas

2015-01-01

A first analysis of a database of shared preclinical safety data for 1214 small molecule drugs and drug candidates extracted from 3970 reports donated by thirteen pharmaceutical companies for the eTOX project (www.etoxproject.eu) is presented. Species, duration of exposure and administration route data were analysed to assess if large enough subsets of homogenous data are available for building in silico predictive models. Prevalence of treatment related effects for the different types of findings recorded were analysed. The eTOX ontology was used to determine the most common treatment-related clinical chemistry and histopathology findings reported in the database. The data were then mined to evaluate sensitivity of established in vivo biomarkers for liver toxicity risk assessment. The value of the database to inform other drug development projects during early drug development is illustrated by a case study.

ToxCast Data Expands Universe of Chemical-Gene Interactions (SOT)

Science.gov (United States)

Characterizing the effects of chemicals in biological systems is often summarized by chemical-gene interactions, which have sparse coverage in literature. The ToxCast chemical screening program has produced bioactivity data for nearly 2000 chemicals and over 450 gene targets. Thi...

Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics

Energy Technology Data Exchange (ETDEWEB)

Kleinstreuer, N.C., E-mail: kleinstreuer.nicole@epa.gov [NCCT, US EPA, RTP, NC 27711 (United States); Smith, A.M.; West, P.R.; Conard, K.R.; Fontaine, B.R. [Stemina Biomarker Discovery, Inc., Madison, WI 53719 (United States); Weir-Hauptman, A.M. [Covance, Inc., Madison, WI 53704 (United States); Palmer, J.A. [Stemina Biomarker Discovery, Inc., Madison, WI 53719 (United States); Knudsen, T.B.; Dix, D.J. [NCCT, US EPA, RTP, NC 27711 (United States); Donley, E.L.R. [Stemina Biomarker Discovery, Inc., Madison, WI 53719 (United States); Cezar, G.G. [Stemina Biomarker Discovery, Inc., Madison, WI 53719 (United States); University of Wisconsin-Madison, Madison, WI 53706 (United States)

2011-11-15

Metabolomics analysis was performed on the supernatant of human embryonic stem (hES) cell cultures exposed to a blinded subset of 11 chemicals selected from the chemical library of EPA's ToxCast Trade-Mark-Sign chemical screening and prioritization research project. Metabolites from hES cultures were evaluated for known and novel signatures that may be indicative of developmental toxicity. Significant fold changes in endogenous metabolites were detected for 83 putatively annotated mass features in response to the subset of ToxCast chemicals. The annotations were mapped to specific human metabolic pathways. This revealed strong effects on pathways for nicotinate and nicotinamide metabolism, pantothenate and CoA biosynthesis, glutathione metabolism, and arginine and proline metabolism pathways. Predictivity for adverse outcomes in mammalian prenatal developmental toxicity studies used ToxRefDB and other sources of information, including Stemina Biomarker Discovery's predictive DevTox Registered-Sign model trained on 23 pharmaceutical agents of known developmental toxicity and differing potency. The model initially predicted developmental toxicity from the blinded ToxCast compounds in concordance with animal data with 73% accuracy. Retraining the model with data from the unblinded test compounds at one concentration level increased the predictive accuracy for the remaining concentrations to 83%. These preliminary results on a 11-chemical subset of the ToxCast chemical library indicate that metabolomics analysis of the hES secretome provides information valuable for predictive modeling and mechanistic understanding of mammalian developmental toxicity. -- Highlights: Black-Right-Pointing-Pointer We tested 11 environmental compounds in a hESC metabolomics platform. Black-Right-Pointing-Pointer Significant changes in secreted small molecule metabolites were observed. Black-Right-Pointing-Pointer Perturbed mass features map to pathways critical for normal

Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics

International Nuclear Information System (INIS)

Kleinstreuer, N.C.; Smith, A.M.; West, P.R.; Conard, K.R.; Fontaine, B.R.; Weir-Hauptman, A.M.; Palmer, J.A.; Knudsen, T.B.; Dix, D.J.; Donley, E.L.R.; Cezar, G.G.

2011-01-01

Metabolomics analysis was performed on the supernatant of human embryonic stem (hES) cell cultures exposed to a blinded subset of 11 chemicals selected from the chemical library of EPA's ToxCast™ chemical screening and prioritization research project. Metabolites from hES cultures were evaluated for known and novel signatures that may be indicative of developmental toxicity. Significant fold changes in endogenous metabolites were detected for 83 putatively annotated mass features in response to the subset of ToxCast chemicals. The annotations were mapped to specific human metabolic pathways. This revealed strong effects on pathways for nicotinate and nicotinamide metabolism, pantothenate and CoA biosynthesis, glutathione metabolism, and arginine and proline metabolism pathways. Predictivity for adverse outcomes in mammalian prenatal developmental toxicity studies used ToxRefDB and other sources of information, including Stemina Biomarker Discovery's predictive DevTox® model trained on 23 pharmaceutical agents of known developmental toxicity and differing potency. The model initially predicted developmental toxicity from the blinded ToxCast compounds in concordance with animal data with 73% accuracy. Retraining the model with data from the unblinded test compounds at one concentration level increased the predictive accuracy for the remaining concentrations to 83%. These preliminary results on a 11-chemical subset of the ToxCast chemical library indicate that metabolomics analysis of the hES secretome provides information valuable for predictive modeling and mechanistic understanding of mammalian developmental toxicity. -- Highlights: ► We tested 11 environmental compounds in a hESC metabolomics platform. ► Significant changes in secreted small molecule metabolites were observed. ► Perturbed mass features map to pathways critical for normal development and pregnancy. ► Arginine, proline, nicotinate, nicotinamide and glutathione pathways were affected.

Persistence of immune responses after a single dose of Novartis meningococcal serogroup A, C, W-135 and Y CRM-197 conjugate vaccine (Menveo®) or Menactra® among healthy adolescents.

Science.gov (United States)

Gill, Christopher J; Baxter, Roger; Anemona, Alessandra; Ciavarro, Giuseppe; Dull, Peter

2010-11-01

The persistence of human bactericidal activity (hSBA) responses in adolescents was assessed 22 months after vaccination with one dose of Menveo® (MenACWY-CRM; Novartis) or Menactra® (MCV4) (sanofi pasteur). The proportion of subjects with hSBA titers ≥8 was significantly higher among recipients of MenACWY-CRM than MCV4 for serogroups A, W-135 and Y.

Structure of Vibrio cholerae ToxT reveals a mechanism for fatty acid regulation of virulence genes

Energy Technology Data Exchange (ETDEWEB)

Lowden, Michael J.; Skorupski, Karen; Pellegrini, Maria; Chiorazzo, Michael G.; Taylor, Ronald K.; Kull, F. Jon (Dartmouth)

2010-03-04

Cholera is an acute intestinal infection caused by the bacterium Vibrio cholerae. In order for V. cholerae to cause disease, it must produce two virulence factors, the toxin-coregulated pilus (TCP) and cholera toxin (CT), whose expression is controlled by a transcriptional cascade culminating with the expression of the AraC-family regulator, ToxT. We have solved the 1.9 {angstrom} resolution crystal structure of ToxT, which reveals folds in the N- and C-terminal domains that share a number of features in common with AraC, MarA, and Rob as well as the unexpected presence of a buried 16-carbon fatty acid, cis-palmitoleate. The finding that cis-palmitoleic acid reduces TCP and CT expression in V. cholerae and prevents ToxT from binding to DNA in vitro provides a direct link between the host environment of V. cholerae and regulation of virulence gene expression.

CAirTOX, An inter-media transfer model for assessing indirect exposures to hazardous air contaminants

International Nuclear Information System (INIS)

McKone, T.E.

1994-01-01

Risk assessment is a quantitative evaluation of information on potential health hazards of environmental contaminants and the extent of human exposure to these contaminants. As applied to toxic chemical emissions to air, risk assessment involves four interrelated steps. These are (1) determination of source concentrations or emission characteristics, (2) exposure assessment, (3) toxicity assessment, and (4) risk characterization. These steps can be carried out with assistance from analytical models in order to estimate the potential risk associated with existing and future releases. CAirTOX has been developed as a spreadsheet model to assist in making these types of calculations. CAirTOX follows an approach that has been incorporated into the CalTOX model, which was developed for the California Department of Toxic Substances Control, With CAirTOX, we can address how contaminants released to an air basin can lead to contamination of soil, food, surface water, and sediments. The modeling effort includes a multimedia transport and transformation model, exposure scenario models, and efforts to quantify uncertainty in multimedia, multiple-pathway exposure assessments. The capacity to explicitly address uncertainty has been incorporated into the model in two ways. First, the spreadsheet form of the model makes it compatible with Monte-Carlo add-on programs that are available for uncertainty analysis. Second, all model inputs are specified in terms of an arithmetic mean and coefficient of variation so that uncertainty analyses can be carried out

Finansowanie leczenia lekami biologicznymi chorych na reumatoidalne i młodzieńcze idiopatyczne zapalenia stawów w ramach programów zdrowotnych NFZ w latach 2004–2008

Directory of Open Access Journals (Sweden)

Andrzej Śliwczyński

2010-02-01

Full Text Available Celem pracy była ocena realizacji obowiązujących w Polscew latach 2004–2008 programów leczenia lekami biologicznymichorych na reumatoidalne i młodzieńcze idiopatyczne zapaleniastawów. Leczenie jest prowadzone przez 81 ośrodków rozmieszczonychrównomiernie w całym kraju. W tym okresie leczonołącznie 8160 chorych. W 2008 r. leczonych było 2282 chorych, costanowi około 2% wszystkich chorych na reumatoidalne zapaleniestawów; 72% z nich stanowiły kobiety, najczęściej w wieku45–55 lat. Lekiem najczęściej stosowanym był etanercept, rzadziejinfliksymab, bardzo rzadko adalimumab i rituksymab. Pieniądzeprzeznaczane przez NFZ na ten rodzaj leczenia nie sąwykorzystywane w pełni, w 2008 r. nie wykorzystano 13,5%.W podsumowaniu podkreślono, że należy zwiększyć liczbę leczonychchorych poprzez poprawienie wykorzystania przeznaczanychnakładów, a następnie ich zwiększenie.

Analysis of ToxCast data for food-relevant compounds by comparison with in vivo data using the RISK21 approach

Science.gov (United States)

The ToxCast program has generated a wealth of in vitro high throughput screening data, and best approaches for the interpretation and use of these data remain undetermined. We present case studies comparing the ToxCast and in vivo toxicity data for two food contact substances us...

Causal Inferences from Mining ToxCast Data and the Biomedical Literature for Molecular Pathways and Cellular Processes in Cleft Palate (SOT)

Science.gov (United States)

Sixty-five chemicals in the ToxCast high-throughput screening (HTS) dataset have been linked to cleft palate based on data from ToxRefDB (rat or rabbit prenatal developmental toxicity studies) or from literature reports. These compounds are structurally diverse and thus likely to...

Yeast Interacting Proteins Database: YBR228W, YLR135W [Yeast Interacting Proteins Database

Lifescience Database Archive (English)

Full Text Available YBR228W SLX1 Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex...of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging r

LimTox: a web tool for applied text mining of adverse event and toxicity associations of compounds, drugs and genes.

Science.gov (United States)

Cañada, Andres; Capella-Gutierrez, Salvador; Rabal, Obdulia; Oyarzabal, Julen; Valencia, Alfonso; Krallinger, Martin

2017-07-03

A considerable effort has been devoted to retrieve systematically information for genes and proteins as well as relationships between them. Despite the importance of chemical compounds and drugs as a central bio-entity in pharmacological and biological research, only a limited number of freely available chemical text-mining/search engine technologies are currently accessible. Here we present LimTox (Literature Mining for Toxicology), a web-based online biomedical search tool with special focus on adverse hepatobiliary reactions. It integrates a range of text mining, named entity recognition and information extraction components. LimTox relies on machine-learning, rule-based, pattern-based and term lookup strategies. This system processes scientific abstracts, a set of full text articles and medical agency assessment reports. Although the main focus of LimTox is on adverse liver events, it enables also basic searches for other organ level toxicity associations (nephrotoxicity, cardiotoxicity, thyrotoxicity and phospholipidosis). This tool supports specialized search queries for: chemical compounds/drugs, genes (with additional emphasis on key enzymes in drug metabolism, namely P450 cytochromes-CYPs) and biochemical liver markers. The LimTox website is free and open to all users and there is no login requirement. LimTox can be accessed at: http://limtox.bioinfo.cnio.es. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

Prediction of metabolites of epoxidation reaction in MetaTox.

Science.gov (United States)

Rudik, A V; Dmitriev, A V; Bezhentsev, V M; Lagunin, A A; Filimonov, D A; Poroikov, V V

2017-10-01

Biotransformation is a process of the chemical modifications which may lead to the reactive metabolites, in particular the epoxides. Epoxide reactive metabolites may cause the toxic effects. The prediction of such metabolites is important for drug development and ecotoxicology studies. Epoxides are formed by some oxidation reactions, usually catalysed by cytochromes P450, and represent a large class of three-membered cyclic ethers. Identification of molecules, which may be epoxidized, and indication of the specific location of epoxide functional group (which is called SOE - site of epoxidation) are important for prediction of epoxide metabolites. Datasets from 355 molecules and 615 reactions were created for training and validation. The prediction of SOE is based on a combination of LMNA (Labelled Multilevel Neighbourhood of Atom) descriptors and Bayesian-like algorithm implemented in PASS software and MetaTox web-service. The average invariant accuracy of prediction (AUC) calculated in leave-one-out and 20-fold cross-validation procedures is 0.9. Prediction of epoxide formation based on the created SAR model is included as the component of MetaTox web-service ( http://www.way2drug.com/mg ).

Mass-Spectrometry Based Structure Identification of "Known-Unknowns" Using the EPA's CompTox Dashboard (ACS Spring National Meeting) 4 of 7

Science.gov (United States)

The CompTox Dashboard is a publicly accessible database provided by the National Center for Computational Toxicology at the US-EPA. The dashboard provides access to a database containing ~720,000 chemicals and integrates a number of our public-facing projects (e.g. ToxCast and Ex...

Developmental status of bioassays in genetic toxicology: a report of Phase II of the US Environmental Protection Agency Gene-Tox program

Energy Technology Data Exchange (ETDEWEB)

Brusick, D; Auletta, A

1985-01-01

The Gene-Tox Program was structured around two phases of genetic test data evaluation. The first phase consisted of 36 Work Group reports, each evaluating the results and performance of a specific bioassay. The second phase consisted of a plan to summarize the information provided by the Work Groups. The Gene-Tox Coordinating Committee was to be responsible for Phase II, and several subgroups were assigned specific goals in implementing this analysis. This report deals with Goal I which is to identify the developmental status of the individual bioassays reviewed by the Gene-Tox Work Groups in the first phase of the Program. 5 references, 6 tables.

CalTOX, a multimedia total exposure model for hazardous-waste sites

International Nuclear Information System (INIS)

McKone, T.E.

1993-06-01

CalTOX has been developed as a spreadsheet model to assist in health-risk assessments that address contaminated soils and the contamination of adjacent air, surface water, sediments, and ground water. The modeling effort includes a multimedia transport and transformation model, exposure scenario models, and efforts to quantify and reduce uncertainty in multimedia, multiple-pathway exposure models. This report provides an overview of the CalTOX model components, lists the objectives of the model, describes the philosophy under which the model was developed, identifies the chemical classes for which the model can be used, and describes critical sensitivities and uncertainties. The multimedia transport and transformation model is a dynamic model that can be used to assess time-varying concentrations of contaminants introduced initially to soil layers or for contaminants released continuously to air or water. This model assists the user in examining how chemical and landscape properties impact both the ultimate route and quantity of human contact. Multimedia, multiple pathway exposure models are used in the CalTOX model to estimate average daily potential doses within a human population in the vicinity of a hazardous substances release site. The exposure models encompass twenty-three exposure pathways. The exposure assessment process consists of relating contaminant concentrations in the multimedia model compartments to contaminant concentrations in the media with which a human population has contact (personal air, tap water, foods, household dusts soils, etc.). The average daily dose is the product of the exposure concentrations in these contact media and an intake or uptake factor that relates the concentrations to the distributions of potential dose within the population

ToxR regulates the production of lipoproteins and the expression of serum resistance in Vibrio cholerae

International Nuclear Information System (INIS)

Parsot, C.; Taxman, E.; Mekalanos, J.J.

1991-01-01

The genes encoding three lipoproteins of Vibrio cholerae were identified by a combination of DNA sequence analysis and [ 3 H]palmitate labeling of hybrid proteins encoded by TnphoA gene fusions. The expression of these three lipoproteins, TagA, AcfD, and TcpC, was controlled by ToxR, the cholera toxin transcriptional activator. The involvement of other bacterial lipoproteins in conferring resistance ot the bactericidal effects of complement prompted us to examine this possibility in V. cholerae. Remarkably, mutations in toxR and tcp genes (including tcpC), involved in the biogenesis of the toxin coregulated pili, rendered V. cholerae about 10 4 - 10 6 times more sensitive to the vibriocidal activity of antibody and complement. Since V. cholerae is a noninvasive organism and toxR and tcp mutants are highly defective in intestinal colonization in animals and humans, these results raise the possibility that resistance to a gut-associated, complement-like bactericidal activity may be a major virulence determinant of V. cholerae and other enterobacterial species

NanoE-Tox: New and in-depth database concerning ecotoxicity of nanomaterials

Directory of Open Access Journals (Sweden)

Katre Juganson

2015-08-01

Full Text Available The increasing production and use of engineered nanomaterials (ENMs inevitably results in their higher concentrations in the environment. This may lead to undesirable environmental effects and thus warrants risk assessment. The ecotoxicity testing of a wide variety of ENMs rapidly evolving in the market is costly but also ethically questionable when bioassays with vertebrates are conducted. Therefore, alternative methods, e.g., models for predicting toxicity mechanisms of ENMs based on their physico-chemical properties (e.g., quantitative (nanostructure-activity relationships, QSARs/QNARs, should be developed. While the development of such models relies on good-quality experimental toxicity data, most of the available data in the literature even for the same test species are highly variable. In order to map and analyse the state of the art of the existing nanoecotoxicological information suitable for QNARs, we created a database NanoE-Tox that is available as . The database is based on existing literature on ecotoxicology of eight ENMs with different chemical composition: carbon nanotubes (CNTs, fullerenes, silver (Ag, titanium dioxide (TiO2, zinc oxide (ZnO, cerium dioxide (CeO2, copper oxide (CuO, and iron oxide (FeOx; Fe2O3, Fe3O4. Altogether, NanoE-Tox database consolidates data from 224 articles and lists altogether 1,518 toxicity values (EC50/LC50/NOEC with corresponding test conditions and physico-chemical parameters of the ENMs as well as reported toxicity mechanisms and uptake of ENMs in the organisms. 35% of the data in NanoE-Tox concerns ecotoxicity of Ag NPs, followed by TiO2 (22%, CeO2 (13%, and ZnO (10%. Most of the data originates from studies with crustaceans (26%, bacteria (17%, fish (13%, and algae (11%. Based on the median toxicity values of the most sensitive organism (data derived from three or more articles the toxicity order was as follows: Ag > ZnO > CuO > CeO2 > CNTs > TiO2 > FeOx. We believe NanoE-Tox database contains

Legacy data sharing to improve drug safety assessment: the eTOX project

DEFF Research Database (Denmark)

Sanz, Ferran; Pognan, François; Steger-Hartmann, Thomas

2017-01-01

The sharing of legacy preclinical safety data among pharmaceutical companies and its integration with other information sources offers unprecedented opportunities to improve the early assessment of drug safety. Here, we discuss the experience of the eTOX project, which was established through...

Extracorporeal Membrane Oxygenation (ECMO) for Severe Toxicological Exposures: Review of the Toxicology Investigators Consortium (ToxIC).

Science.gov (United States)

Wang, G S; Levitan, R; Wiegand, T J; Lowry, J; Schult, R F; Yin, S

2016-03-01

Although there have been many developments related to specific strategies for treating patients after poisoning exposures, the mainstay of therapy remains symptomatic and supportive care. One of the most aggressive supportive modalities is extracorporeal membrane oxygenation (ECMO). Our goal was to describe the use of ECMO for toxicological exposures reported to the American College of Medical Toxicology (ACMT) Toxicology Investigators Consortium (ToxIC). We performed a retrospective review of the ACMT ToxIC Registry from January 1, 2010 to December 31, 2013. Inclusion criteria included patients aged 0 to 89 years, evaluated between January 2010 through December 2013, and received ECMO for toxicological exposure. There were 26,271 exposures (60 % female) reported to the ToxIC Registry, 10 (0.0004 %) received ECMO: 4 pediatric (18 years). Time of initiation of ECMO ranged from 4 h to 4 days, with duration from 15 h to 12 days. Exposures included carbon monoxide/smoke inhalation (2), bitter almonds, methanol, and several medications including antihistamines (2), antipsychotic/antidepressant (2), cardiovascular drugs (2), analgesics (2), sedative/hypnotics (2), and antidiabetics (2). Four ECMO patients received cardiopulmonary resuscitation (CPR) during their hospital course, and the overall survival rate was 80 %. ECMO was rarely used for poisoning exposures in the ACMT ToxIC Registry. ECMO was utilized for a variety of ages and for pharmaceutical and non-pharmaceutical exposures. In most cases, ECMO was administered prior to cardiovascular failure, and survival rate was high. If available, ECMO may be a valid treatment modality.

CAirTOX: A compartment model for assessing the fate of and human exposure to toxic-chemical emissions to air

Energy Technology Data Exchange (ETDEWEB)

McKone, T.E.

1993-10-01

CAirTOX has been developed as a spreadsheet model to assist in making a risk assessment of toxic air emissions. With CAirTOX, one can address how contaminants released to an air basin can lead to contamination of soil, food, surface water, and sediments. The modeling effort includes a multimedia transport and transformation model, exposure scenario models, and efforts to quantify uncertainty in multimedia, multiple-pathway exposure assessments. The multimedia transport and transformation model is a steady-state, but non-equilibrium model that can be used to assess concentrations of contaminants released continuously to air. In Part 1, the authors describe the multimedia transport and transformation model used to determine the fate of air emissions. In Part 2, they describe inputs and data needs for CAirTOX and the development of a set of landscape factors, which can be used to represent regional air basin/water-shed systems in California. In Part 3, they describe the multiple-pathway exposure scenarios and exposure algorithms. In Part 4, they compare the HRA approach and results and the CAirTOX exposure equations. In Part 5, they consider model sensitivity and uncertainty to determine how variability and uncertainty in model inputs affects the precision, accuracy, and credibility of the model output.

Safety of Combination of a Tetravalent Meningococcal Conjugate Vaccine Against Serogroups A, C, Y, W-135 With Other Vaccine Preparations: a Prospective Study of a Series of Cases Among Healthy Children and Children With Various Health Abnormalities

Directory of Open Access Journals (Sweden)

Leyla S. Namazova-Baranova

2017-01-01

Full Text Available Meningococcal infection is an acute disease caused by Neisseria meningitidis, which proceeds with a diverse clinical aspect from nasopharyngitis to meningococcal meningitis and meningococcemia. Since 2014, a tetravalent meningococcal conjugate vaccine has been registered in Russia. This vaccine creates protection against serogroups A, C, W-135, Y and can be used from the age of nine months to 55 years. The actual issue is a vaccine tolerability, including when combined with other vaccine preparations.Objective: Our aim was to evaluate the safety of a tetravalent meningococcal conjugate vaccine against serogroups A, C, Y and W-135 when it is combined with other vaccine preparations.Methods. A prospective full-design study assessed the tolerability of immunization with a meningococcal conjugate vaccine, both in case of monovaccination and in combination with a pneumococcal 13-valent conjugate vaccine, measles-mumps-rubella, viral hepatitis A, influenza, and chicken pox vaccines.Results. 97 children aged from 9 months to 18 years were vaccinated, 20 of them were healthy and 77 had medical issues (with allergic pathology, ENT diseases, cardiovascular and nervous system diseases, lung diseases as well as orphan diseases. Among vaccinated children, general reactions were observed in 3/97 (3.1% children, local reactions — in 5 (5.2%. The post-vaccination period passed asymptomatically and uneventfully in the prevailing majority of children vaccinated with a tetravalent meningococcal conjugate vaccine (in 91, 93.8%.Conclusion. The immunization with a tetravalent meningococcal conjugate vaccine against serogroups A, C, Y, W-135 is well tolerated, both in case of monovaccination and in combination with other vaccine preparations, in healthy children of different age groups and in patients with different health status.

Evaluation of the on-site immunoassay drug-screening device Triage-TOX in routine forensic autopsy.

Science.gov (United States)

Tominaga, Mariko; Michiue, Tomomi; Maeda, Hitoshi

2015-11-01

Instrumental identification of drugs with quantification is essential in forensic toxicology, while on-site immunoassay urinalysis drug-screening devices conveniently provide preliminary information when adequately used. However, suitable or sufficient urine specimens are not always available. The present study evaluated the efficacy of a new on-site immunoassay drug-screening device Triage-TOX (Alere Inc., San Diego, CA, USA), which has recently been developed to provide objective data on the one-step automated processor, using 51 urine and 19 pericardial fluid samples from 66 forensic autopsy cases, compared with Triage-Drug of Abuse (DOA) and Monitect-9. For benzodiazepines, the positive predictive value and specificity of Triage-TOX were higher than those of Triage-DOA; however, sensitivity was higher with Monitect-9, despite frequent false-positives. The results for the other drugs with the three devices also included a few false-negatives and false-positives. These observations indicate the applicability of Triage-TOX in preliminary drug screening using urine or alternative materials in routine forensic autopsy, when a possible false-negative is considered, especially for benzodiazepines, providing objective information; however, the combined use of another device such as Monitect-9 can help minimize misinterpretation prior to instrumental analysis. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Critical appraisal of a quadrivalent CRM(197) conjugate vaccine against meningococcal serogroups A, C W-135 and Y (Menveo) in the context of treatment and prevention of invasive disease.

Science.gov (United States)

Bröker, Michael; Cooper, Brian; Detora, Lisa M; Stoddard, Jeffrey J

2011-01-01

Worldwide, invasive meningococcal disease affects about 500,000 people annually. Case fatality in developed countries averages 10%, and higher rates are reported in less prosperous regions. According to the World Health Organization, the most important pathogenic serogroups are A, B, C, W-135, X, and Y. Clinical features of invasive meningococcal disease make diagnosis and management difficult. Antibiotic measures are recommended for prophylaxis after exposure and for treatment of invasive meningococcal disease cases; however, resistant strains may be emerging. Vaccines are generally regarded as the best preventative measure for invasive meningococcal disease. Polysaccharide vaccines against serogroups A, C, W-135, and Y using protein conjugation technology have clear advantages over older plain polysaccharide formulations without a protein component. The first quadrivalent meningococcal conjugate vaccine (MenACWY-D) was licensed in the US in 2005. More recently, MenACWY-CRM (Menveo(®)) was licensed in Europe, the US, the Middle East, and Latin America. MenACWY-CRM uses cross-reactive material 197, a nontoxic mutant of diphtheria toxin, as the carrier protein. MenACWY-CRM offers robust immunogenicity in all age groups, with a tolerability profile similar to that of a plain polysaccharide vaccine. Given its potential for protecting persons from infancy to old age, MenACWY-CRM offers the opportunity to protect broad populations against invasive meningococcal disease. The most optimal strategy for use of the vaccine has to be assessed country by country on the basis of local epidemiology, individual health care systems, and need.

Seroprevalence and placental transmission of maternal antibodies specific for Neisseria meningitidis Serogroups A, C, Y and W135 and influence of maternal antibodies on the immune response to a primary course of MenACWY-CRM vaccine in the United Kingdom.

Science.gov (United States)

Blanchard-Rohner, Geraldine; Snape, Matthew D; Kelly, Dominic F; O'Connor, Daniel; John, Tessa; Kibwana, Elizabeth; Parks, Hannah; Ford, Karen; Dull, Peter M; Pollard, Andrew J

2013-07-01

Maternal antibodies give neonates some protection against bacterial infection. We measured antibodies against Neisseria meningitidis serogroups A, C, Y and W135 in mothers and their 2-month-old infants at study enrollment. We also assessed the impact of maternal antibody present at 2 months of age on the immune response to a primary course of quadrivalent meningococcal conjugate vaccine (MenACWY-CRM197) given at 2 and 4 months of age. This was a single-center, open-label, randomized study undertaken in Oxford, United Kingdom. Two hundred sixteen healthy infants were enrolled in the study and vaccinated with MenACWY-CRM197 at 2 and 4 months of age. Blood was obtained from all mothers, in a subset of infants at 2 months and all infants at 5 months. Antibody and memory B-cell responses at 5 months were correlated with maternal antibodies. Mothers had low IgG antibodies against serogroups C, W135 and Y polysaccharides, but high serogroup A antibody, whereas 61-78% had protective human complement serum bactericidal activity (hSBA) (≥1:4) for serogroups C, W135 and Y but only 31% for serogroup A. Only 9%, 32%, 45% and 19% of 2-month-old infants had hSBA ≥1:4 for serogroups A, C, W135 and Y, respectively. Maternal antibody had little association on responses to MenACWY-CRM197, except a moderate negative association between MenC-specific bactericidal antibody at 2 and 5 months (r = -0.5, P = 0.006, n = 28) and between carrier-specific IgG antibody at 2 months and MenC-specific hSBA/IgG antibody at 5 months (r = -0.4, P = 0.02 and 0.04, n = 32 and 23). Nonetheless, 90% of infants achieved protective MenC-hSBA titers after vaccination at 2 and 4 months of age. The levels of serogroup-specific meningococcal antibodies were low in mothers and 2-month-old infants. Immunizing mothers before or during pregnancy with meningococcal conjugate vaccines might increase antibody levels in early infancy and provide protection against infection due to N. meningitidis.

Using the US EPA's CompTox Dashboard to support identification and screening of emerging organic contaminants in the environment (ACS Spring National meeting) 2 of 7

Science.gov (United States)

The US EPA’s iCSS CompTox Dashboard is a curated, publicly accessible resource provided by the National Center for Computational Toxicology (https://comptox.epa.gov). The Dashboard provides support for toxicology and risk assessment within and external to the EPA (including ToxC...

ToxPlorerTM: A Comprehensive Knowledgebase of Toxicity Pathways Using Ontology-driven Information Extraction

Science.gov (United States)

Realizing the potential of pathway-based toxicity testing requires a fresh look at how we describe phenomena leading to adverse effects in vivo, how we assess them in vitro and how we extrapolate them in silico across chemicals, doses and species. We developed the ToxPlorer™ fram...

Critical appraisal of a quadrivalent CRM197 conjugate vaccine against meningococcal serogroups A, C W-135 and Y (Menveo®) in the context of treatment and prevention of invasive disease

Science.gov (United States)

Bröker, Michael; Cooper, Brian; DeTora, Lisa M; Stoddard, Jeffrey J

2011-01-01

Worldwide, invasive meningococcal disease affects about 500,000 people annually. Case fatality in developed countries averages 10%, and higher rates are reported in less prosperous regions. According to the World Health Organization, the most important pathogenic serogroups are A, B, C, W-135, X, and Y. Clinical features of invasive meningococcal disease make diagnosis and management difficult. Antibiotic measures are recommended for prophylaxis after exposure and for treatment of invasive meningococcal disease cases; however, resistant strains may be emerging. Vaccines are generally regarded as the best preventative measure for invasive meningococcal disease. Polysaccharide vaccines against serogroups A, C, W-135, and Y using protein conjugation technology have clear advantages over older plain polysaccharide formulations without a protein component. The first quadrivalent meningococcal conjugate vaccine (MenACWY-D) was licensed in the US in 2005. More recently, MenACWY-CRM (Menveo®) was licensed in Europe, the US, the Middle East, and Latin America. MenACWY-CRM uses cross-reactive material 197, a nontoxic mutant of diphtheria toxin, as the carrier protein. MenACWY-CRM offers robust immunogenicity in all age groups, with a tolerability profile similar to that of a plain polysaccharide vaccine. Given its potential for protecting persons from infancy to old age, MenACWY-CRM offers the opportunity to protect broad populations against invasive meningococcal disease. The most optimal strategy for use of the vaccine has to be assessed country by country on the basis of local epidemiology, individual health care systems, and need. PMID:21904459

Neurospora crassa tox-1 Gene Encodes a pH- and Temperature-Tolerant Mini-Cellulase.

Science.gov (United States)

Xiao, Yue; Zhang, Qiongsi; Luo, Yiquan; Zhang, Ying; Luo, Xi; Wang, Yuchuan; Cao, Weiguo; Pinto, Vito De; Liu, Qiuyun; Li, Gang

2016-06-15

Cellulases that endure extreme conditions are essential in various industrial sectors. This study reports a mini-cellulase gene tox-1 from Neurospora crassa. The gene tox-1 was cloned in Escherichia coli after chimerization with the YebF gene and substitutions of certain isoleucine and valine with leucine residues. The yeast transformants could grow on rice straw-agar medium. The 44-amino acid peptide and its two mutant variants displayed potent cellulase activities in Congo Red assay and enzymatic assays. Conservative replacements with leucine have substantially increased the stabilities and half-lives of the peptides at alkaline pH and low and high temperatures and also the tolerance to organic solvents and surfactants, on the basis of activities toward cellose. The small size of the mini-cellulase would allow for commercially viable automatic chemical peptide synthesis. This work suggests that conservative leucine replacements may serve as a general strategy in the engineering of more robust enzymes with special features with little loss of activities.

FORUM - FutureTox II: In vitro Data and In Silico Models for Predictive Toxicology

Science.gov (United States)

FutureTox II, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in January, 2014. The meeting goals were to review and discuss the state of the science in toxicology in the context of implementing the NRC 21st century vision of predicting in vivo resp...

Quantitative Structure-Use Relationship Model Predictions to evaluate Tox21 Chemicals as Functional Substitutes and Candidate Alternatives

Data.gov (United States)

U.S. Environmental Protection Agency — This dataset provides a prediction for all Tox21 chemicals with available QSUR descriptors across all 41 valid QSUR models developed with FUse. This dataset is...

A genetic polymorphism in TOX3 is associated with survival of gastric cancer in a Chinese population.

Directory of Open Access Journals (Sweden)

Xiaojing Zhang

Full Text Available PURPOSE: Recently, genetic polymorphism (rs3803662C>T in TOX3 was reported to induce the risk of breast cancer. In this study, we hypothesized that rs3803662 could influence gastric cancer survival outcomes. METHODS: With multiplex SNaPshot method, we genotyped TOX3 rs3803662 in 880 gastric patients with surgical resection. The association between genotype and survival outcomes was performed by the Kaplan-Meier method, Cox regression analysis models and the log-rank test. RESULTS: There was no association in the analyses of rs3803662 and survival of gastric cancer. However, the stratified analysis by histology showed that rs3803662 CT/TT genotype was associated with a significantly better survival for diffuse-type gastric cancer (log-rank p = 0.030, hazard ratio [HR]  = 0.67, 95% confidence interval [CI]  = 0.46-0.96, than the CC genotype. In addition, this favorable effect was especially obvious among gastric cancer patients with tumor size >5 cm, T3 and T4 depth of invasion, lymph node metastasis, no drinking, no distant metastasis, no chemotherapy and gastric cardia cancer. CONCLUSIONS: TOX3 rs3803662 might play an important role in the prognostic outcome and treatment of gastric cancer, especially perhaps further help in explaining the reduced risk of death associated with diffuse-type gastric cancer.

Metal mixture toxicity to aquatic biota in laboratory experiments: Application of the WHAM-F{sub TOX} model

Energy Technology Data Exchange (ETDEWEB)

Tipping, E., E-mail: et@ceh.ac.uk; Lofts, S.

2013-10-15

Highlights: •Metal accumulation by living organisms is successfully simulated with WHAM. •Modelled organism-bound metal provides a measure of toxic exposure. •The toxic potency of individual bound metals is quantified by fitting toxicity data. •Eleven laboratory mixture toxicity data sets were parameterised. •Relatively little variability amongst individual test organisms is indicated. -- Abstract: The WHAM-F{sub TOX} model describes the combined toxic effects of protons and metal cations towards aquatic organisms through the toxicity function (F{sub TOX}), a linear combination of the products of organism-bound cation and a toxic potency coefficient (α{sub i}) for each cation. Organism-bound, metabolically-active, cation is quantified by the proxy variable, amount bound by humic acid (HA), as predicted by the WHAM chemical speciation model. We compared published measured accumulations of metals by living organisms (bacteria, algae, invertebrates) in different solutions, with WHAM predictions of metal binding to humic acid in the same solutions. After adjustment for differences in binding site density, the predictions were in reasonable line with observations (for logarithmic variables, r{sup 2} = 0.89, root mean squared deviation = 0.44), supporting the use of HA binding as a proxy. Calculated loadings of H{sup +}, Al, Cu, Zn, Cd, Pb and UO{sub 2} were used to fit observed toxic effects in 11 published mixture toxicity experiments involving bacteria, macrophytes, invertebrates and fish. Overall, WHAM-F{sub TOX} gave slightly better fits than a conventional additive model based on solution concentrations. From the derived values of α{sub i}, the toxicity of bound cations can tentatively be ranked in the order: H < Al < (Zn–Cu–Pb–UO{sub 2}) < Cd. The WHAM-F{sub TOX} analysis indicates much narrower ranges of differences amongst individual organisms in metal toxicity tests than was previously thought. The model potentially provides a means to

Developing predictions of in vivo developmental toxicity of ToxCast chemicals using mouse embryonic stem cells.

Science.gov (United States)

Developing predictions of in vivo developmental toxicity of ToxCast chemicals using mouse embryonic stem cells S. Hunter, M. Rosen, M. Hoopes, H. Nichols, S. Jeffay, K. Chandler1, Integrated Systems Toxicology Division, National Health and Environmental Effects Research Labor...

Chemical-Gene Interactions from ToxCast Bioactivity Data Expands Universe of Literature Network-Based Associations (SOT)

Science.gov (United States)

Characterizing the effects of chemicals in biological systems is often summarized by chemical-gene interactions, which have sparse coverage in the literature. The ToxCast chemical screening program has produced bioactivity data for nearly 2000 chemicals and over 450 gene targets....

Flow effect on {sup 135}I and {sup 135}Xe evolution behavior in a molten salt reactor

Energy Technology Data Exchange (ETDEWEB)

Wu, Jianhui; Guo, Chen [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); CAS Center for Excellence in TMSR Energy System, Chinese Academy of Sciences, Shanghai 201800 (China); Cai, Xiangzhou [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); CAS Center for Excellence in TMSR Energy System, Chinese Academy of Sciences, Shanghai 201800 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Yu, Chenggang; Zou, Chunyan [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); CAS Center for Excellence in TMSR Energy System, Chinese Academy of Sciences, Shanghai 201800 (China); Han, Jianlong [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); CAS Center for Excellence in TMSR Energy System, Chinese Academy of Sciences, Shanghai 201800 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Chen, Jingen, E-mail: chenjg@sinap.ac.cn [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); CAS Center for Excellence in TMSR Energy System, Chinese Academy of Sciences, Shanghai 201800 (China); University of Chinese Academy of Sciences, Beijing 100049 (China)

2017-04-01

Highlights: • {sup 135}Xe and {sup 135}I evolution law in a molten salt reactor is analytically deduced. • The circulation of fuel salt through the primary loop decreases the concentration of {sup 135}I and {sup 135}Xe. • {sup 135}I and {sup 135}Xe concentration reduction is independent with the mass flow rate at normal core operating condition. • Increasing the external core volume would raise {sup 135}I and {sup 135}Xe concentration reduction caused by the flow effect. - Abstract: Molten Salt Reactor (MSR) employs fissile material dissolved in the fluoride salt as fuel which continuously circulates through the primary loop with the flow cycle time being a few tens of seconds. The nuclei evolution law is quite different from that in a solid fuel reactor. In this paper, we analytically deduce the nuclei evolution law of {sup 135}Xe and {sup 135}I which are entrained in the flowing salt, evaluate its concentration changing with the burnup time, and validate the result with the SCALE6. The circulation of fuel salt could decrease the concentration of {sup 135}Xe and {sup 135}I, and the reduction can achieve to around 40% and 50% for {sup 135}Xe and {sup 135}I respectively at a small power level (e.g., 2 MW) when the core has the same fuel salt volume as that of the outer-loop. Furthermore, it can be found that the reduction is inversely proportional to the core to outer-loop volume ratio, but uncorrelated with the mass flow rate under normal operating condition of a MSR. At low core power scale, the flow effect on {sup 135}Xe concentration reduction is apparent, but it is mitigated as the core power scale increases because of the rise of {sup 135}I concentration, which raises its decay to {sup 135}Xe and compensates the loss of {sup 135}Xe due to decay at the outer-loop. The decreased {sup 135}Xe concentration results in a core reactivity increase varying from around 150 pcm to 1000 pcm depending on the core power and core to outer-loop volume ratio.

CalTOX, a multimedia total exposure model for hazardous-waste sites; Part 1, Executive summary

Energy Technology Data Exchange (ETDEWEB)

McKone, T.E.

1993-06-01

CalTOX has been developed as a spreadsheet model to assist in health-risk assessments that address contaminated soils and the contamination of adjacent air, surface water, sediments, and ground water. The modeling effort includes a multimedia transport and transformation model, exposure scenario models, and efforts to quantify and reduce uncertainty in multimedia, multiple-pathway exposure models. This report provides an overview of the CalTOX model components, lists the objectives of the model, describes the philosophy under which the model was developed, identifies the chemical classes for which the model can be used, and describes critical sensitivities and uncertainties. The multimedia transport and transformation model is a dynamic model that can be used to assess time-varying concentrations of contaminants introduced initially to soil layers or for contaminants released continuously to air or water. This model assists the user in examining how chemical and landscape properties impact both the ultimate route and quantity of human contact. Multimedia, multiple pathway exposure models are used in the CalTOX model to estimate average daily potential doses within a human population in the vicinity of a hazardous substances release site. The exposure models encompass twenty-three exposure pathways. The exposure assessment process consists of relating contaminant concentrations in the multimedia model compartments to contaminant concentrations in the media with which a human population has contact (personal air, tap water, foods, household dusts soils, etc.). The average daily dose is the product of the exposure concentrations in these contact media and an intake or uptake factor that relates the concentrations to the distributions of potential dose within the population.

The gold-rich indide Sr{sub 5}Au{sub 13.5}In{sub 8.5}

Energy Technology Data Exchange (ETDEWEB)

Muts, Ihor [Ivan Franko National Univ. of Lviv (Ukraine). Inorganic Chemistry Dept.; Muenster Univ. (Germany). Inst. fuer Anorganische und Analytische Chemie; Rodewald, Ute C.; Poettgen, Rainer [Muenster Univ. (Germany). Inst. fuer Anorganische und Analytische Chemie; Zaremba, Vasyl' I. [Ivan Franko National Univ. of Lviv (Ukraine). Inorganic Chemistry Dept.

2011-11-15

The orthorhombic indide Sr{sub 5}Au{sub 13.5}In{sub 8.5} was obtained during phase-analytical studies of the Sr-Au-In system. This new indide is formed upon melting of the elements in a sealed tantalum tube. Sr{sub 5}Au{sub 13.5}In{sub 8.5} was characterized on the basis of powder and single-crystal X-ray diffraction: Pmmn, a = 476.37(9), b = 2927.5(9), c = 894.9(2) pm, wR2 = 0.056, 2355 F{sup 2} values, 87 variables. The structure is of a new type. The gold and indium atoms build up a complex three-dimensional [Au{sub 13.5}In{sub 8.5}] polyanionic network in which the strontium atoms fill channels which extend in the a direction. One site within the polyanion shows Au/In mixing. The Sr{sub 5}Au{sub 13.5}In{sub 8.5} structure is composed of SrAu{sub 3}In{sub 3-} and SrAu-related slabs. (orig.)

A comparison of temporal, spatial and parallel phase shifting algorithms for digital image plane holography

International Nuclear Information System (INIS)

Arroyo, M P; Lobera, J

2008-01-01

This paper investigates the performance of several phase shifting (PS) techniques when using digital image plane holography (DIPH) as a fluid velocimetry technique. The main focus is on increasing the recording system aperture in order to overcome the limitation on the little light available in fluid applications. Some experiments with small rotations of a fluid-like solid object have been used to test the ability of PS-DIPH to faithfully reconstruct the object complex amplitude. Holograms for several apertures and for different defocusing distances have been recorded using spatial phase shifting (SPS) or temporal phase shifting (TPS) techniques. The parallel phase shifted holograms (H PPS ) have been generated from the TPS holograms (H TPS ). The data obtained from TPS-DIPH have been taken as the true object complex amplitude, which is used to benchmark that recovered using the other techniques. The findings of this work show that SPS and PPS are very similar indeed, and suggest that both can work for bigger apertures yet retain phase information

Extrapolation of mammalian-based ToxCast assay results to non-mammalian species to evaluate endocrine disruption

Science.gov (United States)

In vitro high-throughput screening (HTS) and in silico technologies have emerged as 21st century tools for chemical hazard identification. In 2007 the U.S. Environmental Protection Agency (EPA) launched the ToxCast Program, which has screened thousands of chemicals in hundreds of...

Charakterystyka etiologiczna udarów mózgu leczonych w Klinice Neurologii UM w Białymstoku z analizą czynników ryzyka

Directory of Open Access Journals (Sweden)

Anna Syta-Krzyżanowska

2010-03-01

Full Text Available Wstęp: W przeprowadzonych w Polsce badaniach epidemiologicznych stwierdzono utrzymujący się od kilkunastu lat wysoki współczynnik zapadalności na pierwszy w życiu udar mózgu, wzrastający wykładniczo z wiekiem oraz połączony z wciąż dużą śmiertelnością. Poznanie czynników ryzyka oraz wprowadzenie profilaktyki może istotnie zmniejszyć powyższe wskaźniki. Celem pracy było przeprowadzenie analizy epidemiologicznej pacjentów z udarem mózgu hospitalizowanych na Pododdziale Udarowym Kliniki Neurologii USK w Białymstoku. Uwzględniono w szczególności etiologię z czynnikami ryzyka oraz śmiertelnością w zależności od wieku i płci chorych. Materiał i metody: Rozpatrzono wszystkie przypadki pacjentów hospitalizowanych w Klinice Neurologii USK w Białymstoku z powodu udaru mózgu w ciągu pełnego roku kalendarzowego. Posłużono się ankietami prowadzonymi w ramach Narodowego Programu Profilaktyki i Leczenia Chorób Sercowo-Naczyniowych (POLKARD. Obliczenia statystyczne wykonywano przy użyciu programu Statistica w wersji 8.0. Wyniki: Przeanalizowano wyniki 408 pacjentów, w tym 185 (45,3% kobiet oraz 223 (54,7% mężczyzn z rozpoznanym: krwotokiem podpajęczynówkowym – 6,9%, krwotokiem śródmózgowym – 12,5% oraz udarem niedokrwiennym – 80,6%. Etiologię zatorową pochodzenia sercowego zdiagnozowano u 39,4%, zakrzep dużych naczyń u 35%, natomiast udar zatokowy u 11,6% pacjentów. Najczęstszym czynnikiem ryzyka udaru niedokrwiennego mózgu było nadciśnienie tętnicze (81,2%, następnie migotanie przedsionków i choroba niedokrwienna serca (38%. Zmarło 11,6% chorych z udarem niedokrwiennym mózgu oraz 21,5% z udarem krwotocznym. Średnia śmiertelność wyniosła 13,5%. Wnioski: Najczęstszym czynnikiem ryzyka udaru mózgu było nadciśnienie tętnicze, które szczególnie często współwystępowało z dodatkowym czynnikiem ryzyka udaru niedokrwiennego mózgu. Prowadzenie leczenia udaru mózgu w pododdzia

Tox21: Putting a Lens on the Vision of Toxicity Testing in the 21st Century

Science.gov (United States)

In response to the release of the NRC report on "Toxicity Testing in the 21st Century, a Vision and Strategy" (NRC, 2007), two NIH institutes and EPA formed a collaboration (Tox21) to 1) identify mechanisms of chemically induced biological activity, 2) prioritize chemicals for mo...

Human Pluripotent Stem Cell-Based Assay Predicts Developmental Toxicity Potential of ToxCast Chemicals (ACT meeting)

Science.gov (United States)

Worldwide initiatives to screen for toxicity potential among the thousands of chemicals currently in use require inexpensive and high-throughput in vitro models to meet their goals. The devTOX quickPredict platform is an in vitro human pluripotent stem cell-based assay used to as...

Critical appraisal of a quadrivalent CRM197 conjugate vaccine against meningococcal serogroups A, C W-135 and Y (Menveo® in the context of treatment and prevention of invasive disease

Directory of Open Access Journals (Sweden)

Bröker M

2011-07-01

Full Text Available Michael Bröker, Brian Cooper, Lisa M DeTora, Jeffrey J StoddardGlobal Medical Affairs, Novartis Vaccines and Diagnostics, Marburg, Germany, and Cambridge, MA, USAAbstract: Worldwide, invasive meningococcal disease affects about 500,000 people annually. Case fatality in developed countries averages 10%, and higher rates are reported in less prosperous regions. According to the World Health Organization, the most important pathogenic serogroups are A, B, C, W-135, X, and Y. Clinical features of invasive meningococcal disease make diagnosis and management difficult. Antibiotic measures are recommended for prophylaxis after exposure and for treatment of invasive meningococcal disease cases; however, resistant strains may be emerging. Vaccines are generally regarded as the best preventative measure for invasive meningococcal disease. Polysaccharide vaccines against serogroups A, C, W-135, and Y using protein conjugation technology have clear advantages over older plain polysaccharide formulations without a protein component. The first quadrivalent meningococcal conjugate vaccine (MenACWY-D was licensed in the US in 2005. More recently, MenACWY-CRM (Menveo® was licensed in Europe, the US, the Middle East, and Latin America. MenACWY-CRM uses cross-reactive material 197, a nontoxic mutant of diphtheria toxin, as the carrier protein. MenACWY-CRM offers robust immunogenicity in all age groups, with a tolerability profile similar to that of a plain polysaccharide vaccine. Given its potential for protecting persons from infancy to old age, MenACWY-CRM offers the opportunity to protect broad populations against invasive meningococcal disease. The most optimal strategy for use of the vaccine has to be assessed country by country on the basis of local epidemiology, individual health care systems, and need.Keywords: invasive meningococcal disease, quadrivalent meningococcal conjugate vaccine, Neisseria meningitidis

33 CFR 135.3 - Applicability.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Applicability. 135.3 Section 135.3 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND General § 135.3...

Toxicokinetiek van benzo(a)pyreen bij de Riv:TOX rat na herhaalde orale toediening

NARCIS (Netherlands)

Olling M; Lusthof KJ; Kroese ED; Beenen J; Klaassen R; BFT

1995-01-01

Benzo(a)pyrene was administered once daily (30 mg/kg) by gavage to 12 male and 12 female Riv:TOX rats, for 15 days on five successive days per week, in the form of a solution in soy oil. Blood samples were taken over a period of 12 hours on the first day of administration (day 1) and on day 12 from

5 CFR 838.135 - Settlements.

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Settlements. 838.135 Section 838.135 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) COURT... § 838.135 Settlements. (a) OPM must comply with the terms of a properly filed court order acceptable for...

21 CFR 135.130 - Mellorine.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Mellorine. 135.130 Section 135.130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION FROZEN DESSERTS Requirements for Specific Standardized Frozen Desserts § 135.130 Mellorine. (a...

33 CFR 135.101 - Purpose.

Science.gov (United States)

2010-07-01

... FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND Levy of Fees § 135.101 Purpose. (a) The purpose of this subpart is to state the general requirements concerning the levy of fees. ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Purpose. 135.101 Section 135.101...

Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics

Science.gov (United States)

Metabolomics analysis was performed on the supernatant of human embryonic stem (hES) cell cultures exposed to a blinded subset of 11 chemicals selected from the chemical library of EPA's ToxCast™ chemical screening and prioritization research project. Metabolites from hES cultur...

(ENVIRONMENTAL SCIENCE and TECHNOLOGY) An Intuitive Approach for Predicting Human Risk with the Tox21 10k Library

Science.gov (United States)

In vitro to in vivo extrapolation (IVIVE) analyses translating high-throughput screening (HTS) data to human relevance have been limited. This is the first time IVIVE approaches and exposure comparisons have explored the entire Tox21 federal collaboration’s 10,000 chemi...

Development and Evaluation of a Hyperbaric Toxic Gas Monitor (SubTox) for Disabled Submarines

Science.gov (United States)

2013-08-01

air near the CO2 scrubbers was sampled, the common amine/ ammonia smell was present. And while no NH3 sensor was installed in the SubTox, no monitored...under pressure, the eight gases — ammonia , carbon monoxide, chlorine, hydrogen chloride, hydrogen cyanide, hydrogen sulfide, nitrogen dioxide, and...gases for which SEALs have been defined: ammonia (NH3), carbon monoxide (CO), chlorine (Cl2), hydrogen chloride (HCl), hydrogen cyanide (HCN

E-SovTox: An online database of the main publicly-available sources of toxicity data concerning REACH-relevant chemicals published in the Russian language.

Science.gov (United States)

Sihtmäe, Mariliis; Blinova, Irina; Aruoja, Villem; Dubourguier, Henri-Charles; Legrand, Nicolas; Kahru, Anne

2010-08-01

A new open-access online database, E-SovTox, is presented. E-SovTox provides toxicological data for substances relevant to the EU Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) system, from publicly-available Russian language data sources. The database contains information selected mainly from scientific journals published during the Soviet Union era. The main information source for this database - the journal, Gigiena Truda i Professional'nye Zabolevania [Industrial Hygiene and Occupational Diseases], published between 1957 and 1992 - features acute, but also chronic, toxicity data for numerous industrial chemicals, e.g. for rats, mice, guinea-pigs and rabbits. The main goal of the abovementioned toxicity studies was to derive the maximum allowable concentration limits for industrial chemicals in the occupational health settings of the former Soviet Union. Thus, articles featured in the database include mostly data on LD50 values, skin and eye irritation, skin sensitisation and cumulative properties. Currently, the E-SovTox database contains toxicity data selected from more than 500 papers covering more than 600 chemicals. The user is provided with the main toxicity information, as well as abstracts of these papers in Russian and in English (given as provided in the original publication). The search engine allows cross-searching of the database by the name or CAS number of the compound, and the author of the paper. The E-SovTox database can be used as a decision-support tool by researchers and regulators for the hazard assessment of chemical substances. 2010 FRAME.

Variability of Pasteurella multocida isolated from Icelandic sheep and detection of the toxA gene.

Science.gov (United States)

Einarsdottir, Thorbjorg; Gunnarsson, Eggert; Sigurdardottir, Olof G; Jorundsson, Einar; Fridriksdottir, Vala; Thorarinsdottir, Gudridur E; Hjartardottir, Sigridur

2016-09-01

Pasteurella multocida can be part of the upper respiratory flora of animals, but under conditions of stress or immunocompromisation, the bacteria can cause severe respiratory symptoms. In this study, we compared 10 P. multocida isolates from Icelandic sheep with respiratory symptoms and 19 isolates from apparently healthy abattoir sheep. We examined capsule type, genetic variability and the presence of the toxA gene in the two groups. Surprisingly, we found that all ovine P. multocida isolates examined in this study carried the toxA gene, which markedly differs from what has been published from other studies. Interestingly, all isolates from abattoir animals were capsule type D, whilst bacteria isolated from animals with clinical respiratory symptoms had capsule type A, D or F. Examination of seven housekeeping genes indicated that the clinical respiratory isolates were significantly more heterogeneous than the abattoir isolates (P<0.05, two-tailed Mann-Whitney U test). The results suggest that there may be at least two groups of P. multocida in sheep - a genetically homogeneous group that resides in the respiratory tract and a genetically heterogeneous group that is the predominant cause of disease.

Comparative Analysis of Predictive Models for Liver Toxicity Using ToxCast Assays and Quantitative Structure-Activity Relationships (MCBIOS)

Science.gov (United States)

Comparative Analysis of Predictive Models for Liver Toxicity Using ToxCast Assays and Quantitative Structure-Activity Relationships Jie Liu1,2, Richard Judson1, Matthew T. Martin1, Huixiao Hong3, Imran Shah1 1National Center for Computational Toxicology (NCCT), US EPA, RTP, NC...

Virtual Liver: Estimating Proliferation and Apoptosis of Hepatocytes Exposed to Environmental Chemicals Using ToxCastTM Data

Science.gov (United States)

The U.S. EPA’s ToxCastTM program has screened over a thousand chemicals for potential toxicity using hundreds of high-throughput, in vitro assays. The U.S. EPA’s Virtual Liver (v-Liver™) is a cellular systems model of hepatic tissues that enables the estimation of in vivo effects...

22 CFR 135.44 - Termination for convenience.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Termination for convenience. 135.44 Section 135.44 Foreign Relations DEPARTMENT OF STATE MISCELLANEOUS UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS..., Retention, and Enforcement § 135.44 Termination for convenience. Except as provided in § 135.43 awards may...

In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

OpenAIRE

Judson, Richard S.; Houck, Keith A.; Kavlock, Robert J.; Knudsen, Thomas B.; Martin, Matthew T.; Mortensen, Holly M.; Reif, David M.; Rotroff, Daniel M.; Shah, Imran; Richard, Ann M.; Dix, David J.

2009-01-01

Background Chemical toxicity testing is being transformed by advances in biology and computer modeling, concerns over animal use, and the thousands of environmental chemicals lacking toxicity data. The U.S. Environmental Protection Agency?s ToxCast program aims to address these concerns by screening and prioritizing chemicals for potential human toxicity using in vitro assays and in silico approaches. Objectives This project aims to evaluate the use of in vitro assays for understanding the ty...

Overview of Provisional Peer-Reviewed Toxicity Values (PPRTVs), Alternative Methods in Human Health Risk Assessment, and the RapidTox Dashboard

Science.gov (United States)

This poster provides an overview of three key lines of ongoing work at EPA/ORD/NCEA-CIN: Provisional Peer-Reviewed Toxicity Values (PPRTVs), Alternative Methods in Human Health Risk Assessment, and the RapidTox Dashboard collaboration.

14 CFR 135.351 - Recurrent training.

Science.gov (United States)

2010-01-01

... appropriate, including low-altitude windshear training and training on operating during ground icing... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Recurrent training. 135.351 Section 135.351... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Training § 135.351...

33 CFR 135.9 - Fund address.

Science.gov (United States)

2010-07-01

... FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND General § 135.9 Fund address. The address to which correspondence relating to the Coast Guard's administration of the Fund... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Fund address. 135.9 Section 135.9...

46 CFR 133.135 - Rescue boats.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Rescue boats. 133.135 Section 133.135 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS LIFESAVING SYSTEMS Requirements for All OSVs § 133.135 Rescue boats. (a) Each OSV must carry at least one rescue boat. Each rescue...

22 CFR 135.41 - Financial reporting.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Financial reporting. 135.41 Section 135.41... Enforcement § 135.41 Financial reporting. (a) General. (1) Except as provided in paragraphs (a) (2) and (5) of...) Submitting financial reports to Federal agencies, or (ii) Requesting advances or reimbursements when letters...

Probing the ToxCastTM Chemical Library for Predictive Signatures of Developmental Toxicity - Poster at Teratology Society Annual Meeting

Science.gov (United States)

EPA’s ToxCast™ project is profiling the in vitro bioactivity of chemical compounds to assess pathway-level and cell-based signatures that correlate with observed in vivo toxicity. We hypothesize that cell signaling pathways are primary targets for diverse environmental chemicals ...

VirtualToxLab — A platform for estimating the toxic potential of drugs, chemicals and natural products

International Nuclear Information System (INIS)

Vedani, Angelo; Dobler, Max; Smieško, Martin

2012-01-01

The VirtualToxLab is an in silico technology for estimating the toxic potential (endocrine and metabolic disruption, some aspects of carcinogenicity and cardiotoxicity) of drugs, chemicals and natural products. The technology is based on an automated protocol that simulates and quantifies the binding of small molecules towards a series of proteins, known or suspected to trigger adverse effects. The toxic potential, a non-linear function ranging from 0.0 (none) to 1.0 (extreme), is derived from the individual binding affinities of a compound towards currently 16 target proteins: 10 nuclear receptors (androgen, estrogen α, estrogen β, glucocorticoid, liver X, mineralocorticoid, peroxisome proliferator-activated receptor γ, progesterone, thyroid α, and thyroid β), four members of the cytochrome P450 enzyme family (1A2, 2C9, 2D6, and 3A4), a cytosolic transcription factor (aryl hydrocarbon receptor) and a potassium ion channel (hERG). The interface to the technology allows building and uploading molecular structures, viewing and downloading results and, most importantly, rationalizing any prediction at the atomic level by interactively analyzing the binding mode of a compound with its target protein(s) in real-time 3D. The VirtualToxLab has been used to predict the toxic potential for over 2500 compounds: the results are posted on (http://www.virtualtoxlab.org). The free platform — the OpenVirtualToxLab — is accessible (in client–server mode) over the Internet. It is free of charge for universities, governmental agencies, regulatory bodies and non-profit organizations. -- Highlights: ► In silico technology for estimating the toxic potential of drugs and chemicals. ► Simulation of binding towards 16 proteins suspected to trigger adverse effects. ► Mechanistic interpretation and real-time 3D visualization. ► Accessible over the Internet. ► Free of charge for universities, governmental agencies, regulatory bodies and NPOs.

VirtualToxLab — A platform for estimating the toxic potential of drugs, chemicals and natural products

Energy Technology Data Exchange (ETDEWEB)

Vedani, Angelo, E-mail: angelo.vedani@unibas.ch [Biographics Laboratory 3R, Klingelbergstrasse 50, 4056 Basel (Switzerland); Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel (Switzerland); Dobler, Max [Biographics Laboratory 3R, Klingelbergstrasse 50, 4056 Basel (Switzerland); Smieško, Martin [Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel (Switzerland)

2012-06-01

The VirtualToxLab is an in silico technology for estimating the toxic potential (endocrine and metabolic disruption, some aspects of carcinogenicity and cardiotoxicity) of drugs, chemicals and natural products. The technology is based on an automated protocol that simulates and quantifies the binding of small molecules towards a series of proteins, known or suspected to trigger adverse effects. The toxic potential, a non-linear function ranging from 0.0 (none) to 1.0 (extreme), is derived from the individual binding affinities of a compound towards currently 16 target proteins: 10 nuclear receptors (androgen, estrogen α, estrogen β, glucocorticoid, liver X, mineralocorticoid, peroxisome proliferator-activated receptor γ, progesterone, thyroid α, and thyroid β), four members of the cytochrome P450 enzyme family (1A2, 2C9, 2D6, and 3A4), a cytosolic transcription factor (aryl hydrocarbon receptor) and a potassium ion channel (hERG). The interface to the technology allows building and uploading molecular structures, viewing and downloading results and, most importantly, rationalizing any prediction at the atomic level by interactively analyzing the binding mode of a compound with its target protein(s) in real-time 3D. The VirtualToxLab has been used to predict the toxic potential for over 2500 compounds: the results are posted on (http://www.virtualtoxlab.org). The free platform — the OpenVirtualToxLab — is accessible (in client–server mode) over the Internet. It is free of charge for universities, governmental agencies, regulatory bodies and non-profit organizations. -- Highlights: ► In silico technology for estimating the toxic potential of drugs and chemicals. ► Simulation of binding towards 16 proteins suspected to trigger adverse effects. ► Mechanistic interpretation and real-time 3D visualization. ► Accessible over the Internet. ► Free of charge for universities, governmental agencies, regulatory bodies and NPOs.

A randomized study to assess the immunogenicity, antibody persistence and safety of a tetravalent meningococcal serogroups A, C, W-135 and Y tetanus toxoid conjugate vaccine in children aged 2–10 years

Science.gov (United States)

Vesikari, Timo; Forstén, Aino; Boutriau, Dominique; Bianco, Véronique; Van der Wielen, Marie; Miller, Jacqueline M.

2012-01-01

Incidence of meningococcal diseases is high in children, and effective vaccines are needed for this age group. In this phase II, open, controlled study, 309 children aged 2–10 y from Finland were randomized (3:1) into two parallel groups to receive one dose of meningococcal ACWY-tetanus toxoid conjugate vaccine (ACWY-TT group; n = 231) or a licensed meningococcal ACWY polysaccharide vaccine (Men-PS group; n = 78). Serum bactericidal activity using rabbit complement (rSBA) was evaluated up to three years post-vaccination. Exploratory comparisons suggested that rSBA vaccine response rates and geometric mean titers (GMTs) for each serogroup at one month post-vaccination and rSBA GMTs for serogroups A, W-135 and Y up to three years post-vaccination were higher in the ACWY-TT compared with Men-PS group, but did not detect any difference between groups in terms of rSBA-MenC GMTs at three years post-vaccination; this is explained by the higher proportion of children from the Men-PS group who were excluded because they were re-vaccinated with a monovalent meningococcal serogroup C vaccine due to loss of protective antibody levels against this serogroup. Although there was a higher incidence of local reactogenicity in the ACWY-TT group, general and unsolicited symptoms reporting rates were comparable in both groups. This study showed that MenACWY-TT was immunogenic with a clinically acceptable safety profile in children aged 2–10 y. MenACWY-TT induced higher functional antibody titers for all serogroups, which persisted longer for serogroups A, W-135 and Y, than the MenACWY polysaccharide vaccine. This study has been registered at www.clinicaltrials.gov NCT00427908. PMID:23032168

21 CFR 146.135 - Orange juice.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Orange juice. 146.135 Section 146.135 Food and....135 Orange juice. (a) Orange juice is the unfermented juice obtained from mature oranges of the... name of the food is “orange juice”. The name “orange juice” may be preceded on the label by the...

21 CFR 135.160 - Water ices.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Water ices. 135.160 Section 135.160 Food and Drugs... CONSUMPTION FROZEN DESSERTS Requirements for Specific Standardized Frozen Desserts § 135.160 Water ices. (a) Description. Water ices are the foods each of which is prepared from the same ingredients and in the same...

Cross-species extrapolation of mammalian-based ToxCast Data using Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS)

Science.gov (United States)

In vitro high-throughput screening (HTS) and in silico technologies have emerged as 21st century tools for chemical hazard identification. In 2007 the U.S. Environmental Protection Agency (EPA) launched the ToxCast Program, which has screened thousands of chemicals in hundreds of...

CompNanoTox2015: novel perspectives from a European conference on computational nanotoxicology on predictive nanotoxicology

Energy Technology Data Exchange (ETDEWEB)

Bañares, Miguel A. [Instituto de Catalisis y Petroleoquimica, ICP, CSIC, Madrid, Spain,; Haase, Andrea [German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Berlin, Germany,; Tran, Lang [Statistics and Toxicology Section, Institute of Occupational Medicine, Edinburgh, UK,; Lobaskin, Vladimir [School of Physics, University College Dublin, Dublin, Ireland,; Oberdörster, Günter [Department of Environmental Medicine, University of Rochester, Rochester, NY, USA,; Rallo, Robert [Departament d’Enginyeria Informatica i Matematiques, Universitat Rovira i Virgili, Tarragona, Spain,; Advanced Computing, Mathematics, and Data Division, Pacific Northwest National Laboratory, Richland, WA, USA,; Leszczynski, Jerzy [Interdisciplinary Nanotoxicity Center, Jackson State University, Jackson, MS, USA,; Hoet, Peter [Public Health, Unit Lung Toxicology, K. U. Leuven, Leuven, Belgium,; Korenstein, Rafi [Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel,; Hardy, Barry [Technology Park Basel, Douglas Connect GmbH, Basel, Switzerland,; Puzyn, Tomasz [Laboratory of Environmental Chemometrics, Faculty of Chemistry, University of Gdansk, Gdansk, Poland

2017-08-09

A first European Conference on Computational Nanotoxicology, CompNanoTox, was held in November 2015 in Benahavís, Spain with the objectives to disseminate and integrate results from the European modeling and database projects (NanoPUZZLES, ModENPTox, PreNanoTox, MembraneNanoPart, MODERN, eNanoMapper and EU COST TD1204 MODENA) as well as to create synergies within the European NanoSafety Cluster. This conference was supported by the COST Action TD1204 MODENA on developing computational methods for toxicological risk assessment of engineered nanoparticles and provided a unique opportunity for crossfertilization among complementary disciplines. The efforts to develop and validate computational models crucially depend on high quality experimental data and relevant assays which will be the basis to identify relevant descriptors. The ambitious overarching goal of this conference was to promote predictive nanotoxicology, which can only be achieved by a close collaboration between the computational scientists (e.g. database experts, modeling experts for structure, (eco) toxicological effects, performance and interaction of nanomaterials) and experimentalists from different areas (in particular toxicologists, biologists, chemists and material scientists, among others). The main outcome and new perspectives of this conference are summarized here.

33 CFR 135.201 - Applicability.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Applicability. 135.201 Section 135.201 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND...

33 CFR 135.303 - Definitions.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Definitions. 135.303 Section 135.303 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND Notification of...

Streptococcus pneumonia YlxR at 1.35 Å shows a putative new fold

OpenAIRE

Osipiuk, Jerzy; Górnicki, Piotr; Maj, Luke; Dementieva, Irina; Laskowski, Roman; Joachimiak, Andrzej

2001-01-01

The structure of the YlxR protein of unknown function from Streptococcus pneumonia was determined to 1.35 Å. YlxR is expressed from the nusA/infB operon in bacteria and belongs to a small protein family (COG2740) that shares a conserved sequence motif GRGA(Y/W). The family shows no significant amino-acid sequence similarity with other proteins. Three-wavelength diffraction MAD data were collected to 1.7 Å from orthorhombic crystals using synchrotron radiation and the structure was determined ...

33 CFR 135.7 - Delegation-Fund Administrator.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Delegation-Fund Administrator. 135.7 Section 135.7 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... FUND General § 135.7 Delegation—Fund Administrator. (a) The Fund Administrator is delegated authority...

40 CFR 40.135-1 - Preapplication coordination.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Preapplication coordination. 40.135-1 Section 40.135-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE RESEARCH AND DEMONSTRATION GRANTS § 40.135-1 Preapplication coordination. (a) All applicants. (1...

Cheminformatics and Data Mining Approaches for Exploring the Alternatives Testing Landscsape: Case Studies in ToxCast and Skin Sensitization (BOSC CSS)

Science.gov (United States)

Cheminformatics approaches and structure-based rules are being used to evaluate and explore the ToxCast chemical landscape and associated high-throughput screening (HTS) data. We have shown that the library provides comprehensive coverage of the knowledge domains and target inven...

Performance of 100-W HVM LPP-EUV source

Science.gov (United States)

Mizoguchi, Hakaru; Nakarai, Hiroaki; Abe, Tamotsu; Nowak, Krzysztof M.; Kawasuji, Yasufumi; Tanaka, Hiroshi; Watanabe, Yukio; Hori, Tsukasa; Kodama, Takeshi; Shiraishi, Yutaka; Yanagida, Tatsuya; Soumagne, Georg; Yamada, Tsuyoshi; Yamazaki, Taku; Okazaki, Shinji; Saitou, Takashi

2015-08-01

At Gigaphoton Inc., we have developed unique and original technologies for a carbon dioxide laser-produced tin plasma extreme ultraviolet (CO2-Sn-LPP EUV) light source, which is the most promising solution for high-power high-volume manufacturing (HVM) EUV lithography at 13.5 nm. Our unique technologies include the combination of a pulsed CO2 laser with Sn droplets, the application of dual-wavelength laser pulses for Sn droplet conditioning, and subsequent EUV generation and magnetic field mitigation. Theoretical and experimental data have clearly shown the advantage of our proposed strategy. Currently, we are developing the first HVM light source, `GL200E'. This HVM light source will provide 250-W EUV power based on a 20-kW level pulsed CO2 laser. The preparation of a high average-power CO2 laser (more than 20 kW output power) has been completed in cooperation with Mitsubishi Electric Corporation. Recently, we achieved 140 W at 50 kHz and 50% duty cycle operation as well as 2 h of operation at 100 W of power level. Further improvements are ongoing. We will report the latest status and the challenge to reach stable system operation of more than 100 W at about 4% conversion efficiency with 20-μm droplets and magnetic mitigation.

Evaluation of the Neuroactivity of ToxCast Compounds Using Multi-well Microelectrode Array Recordings in Primary Cortical Neurons

Science.gov (United States)

Evaluation of the Neuroactivity of ToxCast Compounds Using Multi-well Microelectrode Array Recordings in Primary Cortical Neurons P Valdivia1, M Martin2, WR LeFew3, D Hall3, J Ross1, K Houck2 and TJ Shafer3 1Axion Biosystems, Atlanta GA and 2NCCT, 3ISTD, NHEERL, ORD, US EPA, RT...

22 CFR 135.33 - Supplies.

Science.gov (United States)

2010-04-01

... supplies exceeding $5,000 in total aggregate fair market value upon termination or completion of the award... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Supplies. 135.33 Section 135.33 Foreign... Supplies. (a) Title. Title to supplies acquired under a grant or subgrant will vest, upon acquisition, in...

17 CFR 230.135a - Generic advertising.

Science.gov (United States)

2010-04-01

... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Generic advertising. 230.135a Section 230.135a Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION GENERAL RULES AND REGULATIONS, SECURITIES ACT OF 1933 General § 230.135a Generic advertising. (a) For the purposes only of...

OpenVirtualToxLab--a platform for generating and exchanging in silico toxicity data.

Science.gov (United States)

Vedani, Angelo; Dobler, Max; Hu, Zhenquan; Smieško, Martin

2015-01-22

The VirtualToxLab is an in silico technology for estimating the toxic potential--endocrine and metabolic disruption, some aspects of carcinogenicity and cardiotoxicity--of drugs, chemicals and natural products. The technology is based on an automated protocol that simulates and quantifies the binding of small molecules towards a series of currently 16 proteins, known or suspected to trigger adverse effects: 10 nuclear receptors (androgen, estrogen α, estrogen β, glucocorticoid, liver X, mineralocorticoid, peroxisome proliferator-activated receptor γ, progesterone, thyroid α, thyroid β), four members of the cytochrome P450 enzyme family (1A2, 2C9, 2D6, 3A4), a cytosolic transcription factor (aryl hydrocarbon receptor) and a potassium ion channel (hERG). The toxic potential of a compound--its ability to trigger adverse effects--is derived from its computed binding affinities toward these very proteins: the computationally demanding simulations are executed in client-server model on a Linux cluster of the University of Basel. The graphical-user interface supports all computer platforms, allows building and uploading molecular structures, inspecting and downloading the results and, most important, rationalizing any prediction at the atomic level by interactively analyzing the binding mode of a compound with its target protein(s) in real-time 3D. Access to the VirtualToxLab is available free of charge for universities, governmental agencies, regulatory bodies and non-profit organizations. Copyright © 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

Predicting dermal penetration for ToxCast chemicals using in silico estimates for diffusion in combination with physiologically based pharmacokinetic (PBPK) modeling.

Science.gov (United States)

Predicting dermal penetration for ToxCast chemicals using in silico estimates for diffusion in combination with physiologically based pharmacokinetic (PBPK) modeling.Evans, M.V., Sawyer, M.E., Isaacs, K.K, and Wambaugh, J.With the development of efficient high-throughput (HT) in ...

The US EPA CompTox Chemistry Dashboard as a source of data to fill data gaps for chemical sources of risk

Science.gov (United States)

Chemical risk assessment is both time-consuming and difficult because it requires the assembly of data for chemicals generally distributed across multiple sources. The US EPA CompTox Chemistry Dashboard is a publicly accessible web-based application providing access to various da...

Real-time prediction of Physicochemical and Toxicological Endpoints Using the Web-based CompTox Chemistry Dashboard (ACS Fall meeting) 10 of 12

Science.gov (United States)

The EPA CompTox Chemistry Dashboard developed by the National Center for Computational Toxicology (NCCT) provides access to data for ~750,000 chemical substances. The data include experimental and predicted data for physicochemical, environmental fate and transport and toxicologi...

Identification of shell-model states in $^{135}$Sb populated via $\\beta^{-}$ decay of $^{135}$Sn

CERN Document Server

Shergur, J; Brown, B A; Cederkäll, J; Dillmann, I; Fraile-Prieto, L M; Hoff, P; Joinet, A; Köster, U; Kratz, K L; Pfeiffer, B; Walters, W B; Wöhr, A

2005-01-01

The $\\beta$- decay of $^{135}$Sn was studied at CERN/ISOLDE using a resonance ionization laser ion source and mass separator to achieve elemental and mass selectivity, respectively. $\\gamma$-ray singles and $\\gamma\\gamma$ coincidence spectra were collected as a function of time with the laser on and with the laser off. These data were used to establish the positions of new levels in $^{135}$Sb, including new low-spin states at 440 and 798 keV, which are given tentative spin and parity assignments of 3/2$^{+}$ and 9/2$^{+}$, respectively. The observed levels of $^{135}$Sb are compared with shell-model calculations using different single-particle energies and different interactions.

Diisopropylammonium methanesulfonate

Directory of Open Access Journals (Sweden)

Guido J. Reiss

2011-08-01

Full Text Available The title molecular salt, C6H16N+·CH3SO3−, has been determined at 150 K. Two diisopropylammonium cations (dipH and two anions form N—H...O hydrogen-bonded cyclic dimers lying around centers of symmetry. Only two of the three O atoms of the methanesulfonate anion are involved in hydrogen bonding, resulting in slightly longer S—O bond lengths. The title structure represents an example of a sulfonate anion that is part of a hydrogen-bonding R44(12 graph-set motif, which is well known for related dipH acetates. Additionally, the Raman and the IR spectroscopic data for the title compound are presented.

Modulation of Xenobiotic Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes by ToxCast Chemicals

Science.gov (United States)

ToxCast chemicals were assessed for induction or suppression of xenobiotic metabolizing enzyme and transporter gene expression using primary human hepatocytes. The mRNA levels of 14 target and 2 control genes were measured: ABCB1, ABCB11, ABCG2, SLCO1B1, CYP1A1, CYP1A2, CYP2B6, C...

33 CFR 135.203 - Amount required.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Amount required. 135.203 Section 135.203 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND...

33 CFR 135.405 - Appeal provisions.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Appeal provisions. 135.405 Section 135.405 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND...

LuminoTox : a tool for the rapid detection of PAH, BPC and chlorobenzenes in waste water and sediments

Energy Technology Data Exchange (ETDEWEB)

Bellemare, F.; Boucher, N.; Lorrain, L.; Rouette, M.E.; Perron, E. [Lab-bell Inc., Shawnigan, PQ (Canada)

2005-07-01

The LuminoTox is a portable fluorimetric detection device capable of assessing water toxicity in 10 to 15 minutes. The toxicity of a water sample is indicated by the modification of fluorescence parameters within isolated both isolated photosynthetic complexes (PECs) and photosynthetic algae (SAPs). An array of 4 LEDs and photodetectors is used to determine fluorescence emissions from PEPs and SAPs. Fluorescence data is then transferred to a computer for analysis. A kinetic detection mode is currently being developed for the tool. This paper provided details of a test conducted to demonstrate the kinetic detection capabilities of the new design. Sediment containing polycyclic aromatic hydrocarbons (PAH), polychlorinated biphenyls, and chlorobenzene were used in the analysis. Results showed that the fluorescence kinetic mode yielded improved sensitivity with molecules acting on the electron transport chain downstream from the tool's photosystem. The test demonstrated that the LuminoTox technology is capable of accurately monitoring the presence of PAHs, PCBs, and chlorobenzenes. It was concluded that the tool is sensitive to a wide range of pollutants and can be used to analyze complex waste water and slurries. 15 refs., 2 tabs., 1 fig.

IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Public Comment Draft)

Science.gov (United States)

EPA is developing an Integrated Risk Information System (IRIS) assessment of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and has released the draft assessment for public comment. When final, the assessment will appear on the IRIS database.

Evaluation of Computational Docking to Identify Pregnane X Receptor Agonists in the ToxCast Database

OpenAIRE

Kortagere, Sandhya; Krasowski, Matthew D.; Reschly, Erica J.; Venkatesh, Madhukumar; Mani, Sridhar; Ekins, Sean

2010-01-01

Background The pregnane X receptor (PXR) is a key transcriptional regulator of many genes [e.g., cytochrome P450s (CYP2C9, CYP3A4, CYP2B6), MDR1] involved in xenobiotic metabolism and excretion. Objectives As part of an evaluation of different approaches to predict compound affinity for nuclear hormone receptors, we used the molecular docking program GOLD and a hybrid scoring scheme based on similarity weighted GoldScores to predict potential PXR agonists in the ToxCast database of pesticides...

Frequency of the GPR7 Tyr135Phe allelic variant in lean and obese subjects.

Science.gov (United States)

Pelosini, C; Maffei, M; Ceccarini, G; Marchi, M; Marsili, A; Galli, G; Scartabelli, G; Tamberi, A; Latrofa, F; Fierabracci, P; Vitti, P; Pinchera, A; Santini, F

2013-10-01

GPR7, the endogenous coupled receptor for neuropeptide B and neuropeptide W, is expressed in several regions of the central nervous system, which are involved in the regulation of feeding behavior. GPR7 affects the regulation of energy balance through a mechanism independent of leptin and melanocortin pathways. Aim of this study was to investigate whether GPR7 gene mutations can be detected in human subjects and, in that event, if they are differently distributed among lean and obese subjects. The coding region of GPR7 were sequenced in 150 obese patients and 100 normal-weight unrelated controls. Functional studies of the allelic variants were performed. One genetic GPR7 variant was found (Tyr135Phe - rs33977775) in obese subjects (13.3%) and lean control (25%). Functional studies did not reveal significant differences between the wild type and the Tyr135Phe allelic variants in their NPW-mediated capacity to inhibit forskolin-induced cAMP production. Screening of GPR7 gene mutations among lean and obese subjects revealed a Tyr135Phe allelic variant that was fairly common in the study population. As indicated by in vitro and in silico studies, this variant is unlikely to cause a functional derangement of the receptor.

14 CFR 135.63 - Recordkeeping requirements.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Recordkeeping requirements. 135.63 Section 135.63 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... concerning the pilot's release from employment for physical or professional disqualification. (x) The date of...

IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5 ...

Science.gov (United States)

The IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) was released for external peer review in September 2016. The EPA’s Science Advisory Board’s (SAB) Chemical Assessment Advisory Committee (CAAC) will conduct a peer review of the scientific basis supporting the RDX assessment and release a final report of their review. Information regarding the peer review can be found on the SAB website. EPA is undertaking an update of the Integrated Risk Information System (IRIS) health assessment for RDX. The outcome of this project is an updated Toxicological Review and IRIS Summary for RDX that will be entered into the IRIS database.

1000 Hours of Testing Completed on 10-kW Hall Thruster

Science.gov (United States)

Mason, Lee S.

2001-01-01

Between the months of April and August 2000, a 10-kW Hall effect thruster, designated T- 220, was subjected to a 1000-hr life test evaluation. Hall effect thrusters are propulsion devices that electrostatically accelerate xenon ions to produce thrust. Hall effect propulsion has been in development for many years, and low-power devices (1.35 kW) have been used in space for satellite orbit maintenance. The T-220, shown in the photo, produces sufficient thrust to enable efficient orbital transfers, saving hundreds of kilograms in propellant over conventional chemical propulsion systems. This test is the longest operation ever achieved on a high-power Hall thruster (greater than 4.5 kW) and is a key milestone leading to the use of this technology for future NASA, commercial, and military missions.

12 CFR 13.5 - Customer information.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Customer information. 13.5 Section 13.5 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY GOVERNMENT SECURITIES SALES...) The customer's investment objectives; and (d) Such other information used or considered to be...

Small-molecule inhibitors of toxT expression in Vibrio cholerae.

Science.gov (United States)

Anthouard, Rebecca; DiRita, Victor J

2013-08-06

Vibrio cholerae, a Gram-negative bacterium, infects humans and causes cholera, a severe disease characterized by vomiting and diarrhea. These symptoms are primarily caused by cholera toxin (CT), whose production by V. cholerae is tightly regulated by the virulence cascade. In this study, we designed and carried out a high-throughput chemical genetic screen to identify inhibitors of the virulence cascade. We identified three compounds, which we named toxtazin A and toxtazin B and B', representing two novel classes of toxT transcription inhibitors. All three compounds reduce production of both CT and the toxin-coregulated pilus (TCP), an important colonization factor. We present evidence that toxtazin A works at the level of the toxT promoter and that toxtazins B and B' work at the level of the tcpP promoter. Treatment with toxtazin B results in a 100-fold reduction in colonization in an infant mouse model of infection, though toxtazin A did not reduce colonization at the concentrations tested. These results add to the growing body of literature indicating that small-molecule inhibitors of virulence genes could be developed to treat infections, as alternatives to antibiotics become increasingly needed. V. cholerae caused more than 580,000 infections worldwide in 2011 alone (WHO, Wkly. Epidemiol. Rec. 87:289-304, 2012). Cholera is treated with an oral rehydration therapy consisting of water, glucose, and electrolytes. However, as V. cholerae is transmitted via contaminated water, treatment can be difficult for communities whose water source is contaminated. In this study, we address the need for new therapeutic approaches by targeting the production of the main virulence factor, cholera toxin (CT). The high-throughput screen presented here led to the identification of two novel classes of inhibitors of the virulence cascade in V. cholerae, toxtazin A and toxtazins B and B'. We demonstrate that (i) small-molecule inhibitors of virulence gene production can be

14 CFR 135.125 - Aircraft security.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Aircraft security. 135.125 Section 135.125....125 Aircraft security. Certificate holders conducting operators conducting operations under this part must comply with the applicable security requirements in 49 CFR chapter XII. [67 FR 8350, Feb. 22, 2002] ...

IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (External Review Draft)

Science.gov (United States)

The IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) was released for external peer review in September 2016. The EPA’s Science Advisory Board’s (SAB) Chemical Assessment Advisory Committee (CAAC) will conduct a peer review of the scientific basis suppor...

21 CFR 135.115 - Goat's milk ice cream.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Goat's milk ice cream. 135.115 Section 135.115 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION FROZEN DESSERTS Requirements for Specific Standardized Frozen Desserts § 135.115...

21 CFR 163.135 - Buttermilk chocolate.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Buttermilk chocolate. 163.135 Section 163.135 Food... Buttermilk chocolate. (a) Description. Buttermilk chocolate is the food that conforms to the standard of identity, and is subject to the requirements for label declaration of ingredients for milk chocolate in...

29 CFR 1910.135 - Head protection.

Science.gov (United States)

2010-07-01

... 29 Labor 5 2010-07-01 2010-07-01 false Head protection. 1910.135 Section 1910.135 Labor... head protection. (1) Head protection must comply with any of the following consensus standards: (i... consensus standards will be deemed to be in compliance with the requirements of this section. [59 FR 16362...

22 CFR 135.25 - Program income.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Program income. 135.25 Section 135.25 Foreign... income. (a) General. Grantees are encouraged to earn income to defray program costs. Program income includes income from fees for services performed, from the use or rental of real or personal property...

25 CFR 135.23 - Refusal of water delivery.

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Refusal of water delivery. 135.23 Section 135.23 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES CONSTRUCTION ASSESSMENTS, CROW... District § 135.23 Refusal of water delivery. The right is reserved to refuse the delivery of water to any...

21 CFR 172.135 - Disodium EDTA.

Science.gov (United States)

2010-04-01

..., other than black-eyed peas) 165 Promote color retention. Mayonnaise 75 Preservative. Ready-to-eat cereal... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Disodium EDTA. 172.135 Section 172.135 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN...

25 CFR 135.6 - Refusal of water delivery.

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Refusal of water delivery. 135.6 Section 135.6 Indians... INDIAN IRRIGATION PROJECT Charges Assessed Against Irrigation District Lands § 135.6 Refusal of water delivery. The right is reserved to the United States to refuse the delivery of water to each of the said...

Conjugated Linoleic Acid Reduces Cholera Toxin Production In Vitro and In Vivo by Inhibiting Vibrio cholerae ToxT Activity.

Science.gov (United States)

Withey, Jeffrey H; Nag, Drubhajyoti; Plecha, Sarah C; Sinha, Ritam; Koley, Hemanta

2015-12-01

The severe diarrheal disease cholera is endemic in over 50 countries. Current therapies for cholera patients involve oral and/or intravenous rehydration, often combined with the use of antibiotics to shorten the duration and intensity of the disease. However, as antibiotic resistance increases, treatment options will become limited. Linoleic acid has been shown to be a potent negative effector of V. cholerae virulence that acts on the major virulence transcription regulator protein, ToxT, to inhibit virulence gene expression. ToxT activates transcription of the two major virulence factors required for disease, cholera toxin (CT) and toxin-coregulated pilus (TCP). A conjugated form of linoleic acid (CLA) is currently sold over the counter as a dietary supplement and is generally recognized as safe by the U.S. Food and Drug Administration. This study examined whether CLA could be used as a new therapy to reduce CT production, which, in turn, would decrease disease duration and intensity in cholera patients. CLA could be used in place of traditional antibiotics and would be very unlikely to generate resistance, as it affects only virulence factor production and not bacterial growth or survival. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

The eTOX Data-Sharing Project to Advance in Silico Drug-Induced Toxicity Prediction

Directory of Open Access Journals (Sweden)

Montserrat Cases

2014-11-01

Full Text Available The high-quality in vivo preclinical safety data produced by the pharmaceutical industry during drug development, which follows numerous strict guidelines, are mostly not available in the public domain. These safety data are sometimes published as a condensed summary for the few compounds that reach the market, but the majority of studies are never made public and are often difficult to access in an automated way, even sometimes within the owning company itself. It is evident from many academic and industrial examples, that useful data mining and model development requires large and representative data sets and careful curation of the collected data. In 2010, under the auspices of the Innovative Medicines Initiative, the eTOX project started with the objective of extracting and sharing preclinical study data from paper or pdf archives of toxicology departments of the 13 participating pharmaceutical companies and using such data for establishing a detailed, well-curated database, which could then serve as source for read-across approaches (early assessment of the potential toxicity of a drug candidate by comparison of similar structure and/or effects and training of predictive models. The paper describes the efforts undertaken to allow effective data sharing intellectual property (IP protection and set up of adequate controlled vocabularies and to establish the database (currently with over 4000 studies contributed by the pharma companies corresponding to more than 1400 compounds. In addition, the status of predictive models building and some specific features of the eTOX predictive system (eTOXsys are presented as decision support knowledge-based tools for drug development process at an early stage.

1,3,5-Triazine-2,4,6-tribenzaldehyde derivative as a new crosslinking agent for synthesis of pH-thermo dual responsive chitosan hydrogels and their nanocomposites: Swelling properties and drug release behavior.

Science.gov (United States)

Karimi, Ali Reza; Tarighatjoo, Mahsa; Nikravesh, Golara

2017-12-01

In this work, 1,3,5-triazine-2,4,6-tribenzaldehyde was synthesized and chosen as the cross-linking agent for preparation of novel thermo- and pH-responsive hydrogels based on chitosan. The cross-linking proceeds through formation of imine bond by reaction of amino groups of chitosan with aldehyde groups of the cross-linker. The various amounts (6, 10, 14% w/w) of the cross-linker were used with respect to chitosan to produce three 1,3,5-triazine-2,4,6-tribenzaldehyde cross-linked chitosans. Then, their hydrogel nanocomposites were prepared by crosslinking of chitosan with 1,3,5-triazine-2,4,6-tribenzaldehyde in the presence of 0.1% and 0.3% (w/w) multi-walled carbon nanotubes (MWCNTs). The structure and properties of the hydrogels and their nanocomposites were characterized by FT-IR, 1 H NMR and scanning electron microscopy (SEM). The swelling behavior of prepared hydrogels and their nanocomposites at different pHs and temperatures was investigated. The results showed that they exhibit a pH and temperature-responsive swelling ratio. The swelling behavior of the prepared chitosan hydrogels was strongly dependent on the amounts of cross-linker and MWCNTs. In vitro controlled release behavior of metronidazole model drug was studied with prepared hydrogels and nanocomposite hydrogels. The pH, temperature and wt% of MWCNTs were found to strongly influence the drug release behavior of the hydrogels. Copyright © 2017 Elsevier B.V. All rights reserved.

33 CFR 135.221 - Reapplication for certification.

Science.gov (United States)

2010-07-01

... (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND Financial Responsibility for Offshore Facilities § 135.221 Reapplication for certification. (a) If... certificate must be immediately submitted to the Fund Administrator in accordance with § 135.204. ...

Computation Modeling of Limb-bud Dysmorphogenesis: Predicting Cellular Dynamics and Key Events in Developmental Toxicity with a Multicellular Systems Model (FutureToxII)

Science.gov (United States)

Congenital limb malformations are among the most frequent malformation occurs in humans, with a frequency of about 1 in 500 to 1 in 1000 human live births. ToxCast is profiling the bioactivity of thousands of chemicals based on high-throughput (HTS) and computational methods that...

IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Interagency Science Consultation Draft)

Science.gov (United States)

On March 10, 2016, the public comment draft Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine and the draft charge to external peer reviewers were released for public review and comment. The Toxicological Review and charge were reviewed internally by EPA and by othe...

33 CFR 135.204 - Submission of evidence.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Submission of evidence. 135.204 Section 135.204 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND...

Half-lives of 132La and 135La

Science.gov (United States)

Abel, E. P.; Clause, H. K.; Fonslet, J.; Nickles, R. J.; Severin, G. W.

2018-03-01

The half-lives of 135La and 132La were determined via serial gamma spectroscopy, and the half-life of 135La was further determined by a high-precision ionization-chamber measurement. The results are 18.91(2) hr for 135La and 4.59(4) hr for 132La compared with the previously compiled values of 19.5(2) hr and 4.8(2) hr, respectively. These lanthanum isotopes comprise a medically interesting system with positron emitter 132La and Auger-electron emitter 135La forming a theranostic pair for internal diagnostics and therapeutics. The precise half-lives are necessary for proper evaluation of their value in medicine and for a more representative tabulation of nuclear data.

135Cs activity and 135Cs/137Cs atom ratio in environmental samples before and after the Fukushima Daiichi Nuclear Power Plant accident.

Science.gov (United States)

Yang, Guosheng; Tazoe, Hirofumi; Yamada, Masatoshi

2016-04-07

(135)Cs/(137)Cs is a potential tracer for radiocesium source identification. However, due to the challenge to measure (135)Cs, there were no (135)Cs data available for Japanese environmental samples before the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident. It was only 3 years after the accident that limited (135)Cs values could be measured in heavily contaminated environmental samples. In the present study, activities of (134)Cs, (135)Cs, and (137)Cs, along with their ratios in 67 soil and plant samples heavily and lightly contaminated by the FDNPP accident were measured by combining γ spectrometry with ICP-MS/MS. The arithmetic means of the (134)Cs/(137)Cs activity ratio (1.033 ± 0.006) and (135)Cs/(137)Cs atom ratio (0.334 ± 0.005) (decay corrected to March 11, 2011), from old leaves of plants collected immediately after the FDNPP accident, were confirmed to represent the FDNPP derived radiocesium signature. Subsequently, for the first time, trace (135)Cs amounts before the FDNPP accident were deduced according to the contribution of global and FDNPP accident-derived fallout. Apart from two soil samples with a tiny global fallout contribution, contributions of global fallout radiocesium in other soil samples were observed to be 0.338%-52.6%. The obtained (135)Cs/(137)Cs database will be useful for its application as a geochemical tracer in the future.

Distribution of the ompA-types among ruminant and swine pneumonic strains of Pasteurella multocida exhibiting various cap-locus and toxA patterns.

Science.gov (United States)

Vougidou, C; Sandalakis, V; Psaroulaki, A; Siarkou, V; Petridou, E; Ekateriniadou, L

2015-05-01

Pasteurella multocida is an important pathogen in food-producing animals and numerous virulence genes have been identified in an attempt to elucidate the pathogenesis of pasteurellosis. Currently, some of these genes including the capsule biosynthesis genes, the toxA and the OMPs-encoding genes have been suggested as epidemiological markers. However, the number of studies concerning ruminant isolates is limited, while, no attempt has ever been made to investigate the existence of ompA sequence diversity among P. multocida isolates. The aim of the present study was the comparative analysis of 144 P. multocida pneumonic isolates obtained from sheep, goats, cattle and pigs by determining the distribution of the ompA-types in conjunction with the cap-locus and toxA patterns. The ompA genotypes of the isolates were determined using both a PCR-RFLP method and DNA sequence analysis. The most prevalent capsule biosynthesis gene among the isolates was capA (86.1%); a noticeable, however, rate of capD-positive isolates (38.6%) was found among the ovine isolates that had been associated primarily with the capsule type A in the past. Moreover, an unexpectedly high percentage of toxA-positive pneumonic isolates was noticed among small ruminants (93.2% and 85.7% in sheep and goats, respectively), indicating an important epidemiological role of toxigenic P. multocida for these species. Despite their great heterogeneity, certain ompA-genotypes were associated with specific host species, showing evidence of a host preference. The OmpA-based PCR-RFLP method developed proved to be a valuable tool in typing P. multocida strains. Copyright © 2015 Elsevier GmbH. All rights reserved.

6 CFR 13.5 - Review by the Reviewing Official.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Review by the Reviewing Official. 13.5 Section 13.5 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.5 Review by the Reviewing Official. (a) If, based on the report of the Investigating Official...

The EPA CompTox Dashboard and Underpinning Software Architecture – a platform for data integration for environmental chemistry data (ACS Fall Meeting 7 of 12)

Science.gov (United States)

The CompTox Dashboard was developed by the Environmental Protection Agency’s National Center for Computational Toxicology. This dashboard has been architected in a manner that allows for the deployment of multiple “applications”, both as publicly available databases, and for dep...

9 CFR 3.134-3.135 - [Reserved

Science.gov (United States)

2010-01-01

... Warmblooded Animals Other Than Dogs, Cats, Rabbits, Hamsters, Guinea Pigs, Nonhuman Primates, and Marine... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false [Reserved] 3.134-3.135 Section 3.134-3.135 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...

24 CFR 135.7 - Delegation of authority.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Delegation of authority. 135.7... Provisions § 135.7 Delegation of authority. Except as may be otherwise provided in this part, the functions... authorized to redelegate functions and responsibilities to other employees of HUD; provided however, that the...

KC-135 Operations Facility

Data.gov (United States)

Federal Laboratory Consortium — The KC-135 Low-G Flight Research aircraft (a predecessor of the Boeing 707) is used to fly parabolas to create 20-25 seconds of weightlessness so that the astronauts...

Effect of two major N-nitroso hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) metabolites on earthworm reproductive success

International Nuclear Information System (INIS)

Zhang Baohong; Cox, Stephen B.; McMurry, Scott T.; Jackson, W. Andrew; Cobb, George P.; Anderson, Todd A.

2008-01-01

Soil and topical tests were employed to investigate the effect of two N-nitroso metabolites of RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) on earthworm reproduction. The lowest observed effect concentration (LOEC) for cocoon production and hatching was 50 mg/kg for both hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX) and hexahydro-1,3,5-trinitroso-1,3,5-triazine (TNX) in soil. MNX and TNX also significantly affected cocoon hatching in soil (p 20 values for MNX were 8.7 and 8.8 mg/kg for cocoon and juvenile production, respectively, compared to 9.2 and 9.1 mg/kg for TNX, respectively. The EC 20 values for the total number of cocoon hatchlings were 3.1 and 4.7 mg/kg for MNX and TNX, respectively, in soil and 4.5 and 3.1 mg/L in the topical test. Both MNX and TNX inhibited cocoon production and hatching, suggesting that they may have a negative affect on soil ecosystems at contaminated sites. - RDX metabolites affect earthworm cocoon production and hatching

Comparison of Flight Measured, Predicted and Wind Tunnel Measured Winglet Characteristics on a KC-135 Aircraft

Science.gov (United States)

Dodson, R. O., Jr.

1982-01-01

One of the objectives of the KC-135 Winglet Flight Research and Demonstration Program was to obtain experimental flight test data to verify the theoretical and wind tunnel winglet aerodynamic performance prediction methods. Good agreement between analytic, wind tunnel and flight test performance was obtained when the known differences between the tests and analyses were accounted for. The flight test measured fuel mileage improvements for a 0.78 Mach number was 3.1 percent at 8 x 10(5) pounds W/delta and 5.5 percent at 1.05 x 10(6) pounds W/delta. Correcting the flight measured data for surface pressure differences between wind tunnel and flight resulted in a fuel mileage improvement of 4.4 percent at 8 x 10(5) pounds W/delta and 7.2 percent at 1.05 x 10(6) pounds W/delta. The performance improvement obtained was within the wind tunnel test data obtained from two different wind tunnel models. The buffet boundary data obtained for the baseline configuration was in good agreement with previous established data. Buffet data for the 15 deg cant/-4 deg incidence configuration showed a slight improvement, while the 15 deg cant/-2 deg incidence and 0 deg cant/-4 deg incidence data showed a slight deterioration.

75 FR 10026 - Proposed Collection; Comment Request for Forms W-2, W-2c, W-2AS, W-2GU, W-2VI, W-3, W-3c, W-3cPR...

Science.gov (United States)

2010-03-04

... W-2, W-2c, W-2AS, W-2GU, W-2VI, W-3, W-3c, W-3cPR, W-3PR, and W-3SS AGENCY: Internal Revenue Service....C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning Forms W-2, W-2c, W-2AS, W-2GU, W-2VI, W-3, W-3c, W- 3cPR, W-3PR, and W-3SS. DATES: Written comments should be received on or...

24 CFR 964.135 - Resident involvement in HA management operations.

Science.gov (United States)

2010-04-01

... management operations. 964.135 Section 964.135 Housing and Urban Development Regulations Relating to Housing... Tenant Participation § 964.135 Resident involvement in HA management operations. Residents shall be... responsibility for management operations, it shall ensure strong resident participation in all issues and facets...

Using semi-automated curation workflows to collect, organize, and curate the data and models necessary to support the EPA CompTox chemical dashboard (ACS Spring meeting)

Science.gov (United States)

With the increasing need to leverage data and models to perform cutting edge analyses within the environmental science community, collection and organization of that data into a readily accessible format for consumption is a pressing need. The EPA CompTox chemical dashboard is i...

GENE EXPRESSION CHANGES IN ARABIDOPSIS THALIANA SEEDLING ROOTS EXPOSED TO THE MUNITION HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE

Science.gov (United States)

Arabidopsis thaliana root transcriptome responses to the munition, hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), were assessed using serial analysis of gene expression (SAGE). Comparison of the transcriptional profile for the RDX response to a profile previously described for Ar...

ADME-Tox profiling of some low molecular weight water soluble chitosan derivatives

Directory of Open Access Journals (Sweden)

Adriana Isvoran

2017-09-01

Full Text Available Within this study we use a few computational tools for predicting absorption, distribution, metabolism, excretion and toxicity (ADME-Tox, pharmacokinetics profiles, toxic/adverse effects, carcinogenicity, cardiotoxicity and endocrine disruption of some of low molecular weight water soluble derivatives of chitosan that are used in wound healing. Investigated compounds do not possess drug-like properties, their pharmacokinetics profiles reveal poor gastrointestinal absorption and low skin penetration. Chitosan derivatives cannot pass the blood-brain barrier and they are not able to inhibit the enzymes of the cytochrome P450 that are involved in the metabolism of xenobiotics. They do not reflect carcinogenicity and cardiotoxicity and reveal only a low probability to be endocrine disruptors. The main side effects in humans of the investigated compounds are: weight loss, acidosis, gastrointestinal toxicity, respiratory failure. This information is especially important for professional exposure and accidental contamination with these compounds.

Cell-Based High-Throughput Screening for Aromatase Inhibitors in the Tox21 10K Library.

Science.gov (United States)

Chen, Shiuan; Hsieh, Jui-Hua; Huang, Ruili; Sakamuru, Srilatha; Hsin, Li-Yu; Xia, Menghang; Shockley, Keith R; Auerbach, Scott; Kanaya, Noriko; Lu, Hannah; Svoboda, Daniel; Witt, Kristine L; Merrick, B Alex; Teng, Christina T; Tice, Raymond R

2015-10-01

Multiple mechanisms exist for endocrine disruption; one nonreceptor-mediated mechanism is via effects on aromatase, an enzyme critical for maintaining the normal in vivo balance of androgens and estrogens. We adapted the AroER tri-screen 96-well assay to 1536-well format to identify potential aromatase inhibitors (AIs) in the U.S. Tox21 10K compound library. In this assay, screening with compound alone identifies estrogen receptor alpha (ERα) agonists, screening in the presence of testosterone (T) identifies AIs and/or ERα antagonists, and screening in the presence of 17β-estradiol (E2) identifies ERα antagonists. Screening the Tox-21 library in the presence of T resulted in finding 302 potential AIs. These compounds, along with 31 known AI actives and inactives, were rescreened using all 3 assay formats. Of the 333 compounds tested, 113 (34%; 63 actives, 50 marginal actives) were considered to be potential AIs independent of cytotoxicity and ER antagonism activity. Structure-activity analysis suggested the presence of both conventional (eg, 1, 2, 4, - triazole class) and novel AI structures. Due to their novel structures, 14 of the 63 potential AI actives, including both drugs and fungicides, were selected for confirmation in the biochemical tritiated water-release aromatase assay. Ten compounds were active in the assay; the remaining 4 were only active in high-throughput screen assay, but with low efficacy. To further characterize these 10 novel AIs, we investigated their binding characteristics. The AroER tri-screen, in high-throughput format, accurately and efficiently identified chemicals in a large and diverse chemical library that selectively interact with aromatase. © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

[Ideas and methods on efficient screening of traditional medicines for anti-osteoporosis activity based on M-Act/Tox integrated evaluation using zebrafish].

Science.gov (United States)

Wang, Mo; Ling, Jie; Chen, Ying; Song, Jie; Sun, E; Shi, Zi-Qi; Feng, Liang; Jia, Xiao-Bin; Wei, Ying-Jie

2017-11-01

The increasingly apparent liver injury problems of bone strengthening Chinese medicines have brought challenges for clinical application, and it is necessary to consider both effectiveness and safety in screening anti-osteoporosis Chinese medicines. Metabolic transformation is closely related to drug efficacy and toxicity, so it is significant to comprehensively consider metabolism-action/toxicity(M-Act/Tox) for screening anti-osteoporosis Chinese medicines. The current evaluation models and the number of compounds(including metabolites) severely restrict efficient screening in vivo. By referring to previous relevant research and domestic and abroad literature, zebrafish M-Act/Tox integrative method was put forward for efficiently screening anti-osteoporosis herb medicines, which has organically integrated zebrafish metabolism model, osteoporosis model and toxicity evaluation method. This method can break through the bottleneck and blind spots that trace compositions can't achieve efficient and integrated in vivo evaluation, and realize both efficient and comprehensive screening on anti-osteoporosis traditional medicines based on in vivo process taking both safety and effectiveness into account, which is significant to accelerate discovery of effective and safe innovative traditional Chinese medicines for osteoporosis. Copyright© by the Chinese Pharmaceutical Association.

40 CFR 63.135 - Process wastewater provisions-containers.

Science.gov (United States)

2010-07-01

...-containers. 63.135 Section 63.135 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... wastewater provisions—containers. (a) For each container that receives, manages, or treats a Group 1... operate and maintain a cover on each container used to handle, transfer, or store a Group 1 wastewater...

Effects of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) metabolites on cricket (Acheta domesticus) survival and reproductive success

Energy Technology Data Exchange (ETDEWEB)

Zhang Baohong [Institute of Environmental and Human Health (TIEHH), and Department of Environmental Toxicology, Texas Tech University, Box 41163, Lubbock, TX 79409-1163 (United States); Freitag, Christina M. [Institute of Environmental and Human Health (TIEHH), and Department of Environmental Toxicology, Texas Tech University, Box 41163, Lubbock, TX 79409-1163 (United States); Canas, Jaclyn E. [Institute of Environmental and Human Health (TIEHH), and Department of Environmental Toxicology, Texas Tech University, Box 41163, Lubbock, TX 79409-1163 (United States); Cheng Qiuqiong [Institute of Environmental and Human Health (TIEHH), and Department of Environmental Toxicology, Texas Tech University, Box 41163, Lubbock, TX 79409-1163 (United States); Anderson, Todd A. [Institute of Environmental and Human Health (TIEHH), and Department of Environmental Toxicology, Texas Tech University, Box 41163, Lubbock, TX 79409-1163 (United States)]. E-mail: todd.anderson@tiehh.ttu.edu

2006-11-15

The effect of two major hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) metabolites, hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX) and hexahydro-1,3,5-trinitroso-1,3,5-triazine (TNX), on cricket (Acheta domesticus) survival and reproduction was studied. RDX metabolites did not have adverse effects on cricket survival, growth, and egg production. However, MNX and TNX did affect egg hatching. MNX and TNX were more toxic in spiked-sand than in topical tests. TNX was more toxic to egg than MNX. Developmental stage and exposure time affected hatching. After 30 days exposure to MNX or TNX, the EC{sub 2}, EC{sub 5}, and EC{sub 95} were 47, 128, and 247 {mu}g/g for TNX, and 65, 140, and 253 {mu}g/g for MNX in topical tests. The ECs for 20, 50, and 95 were 21, 52, and 99 {mu}g/g for MNX, and 12, 48, and 97 {mu}g/g for TNX in sand. No gross abnormalities in cricket nypmhs were observed in all experiments indicating that neither TNX or MNX is teratogenic in this assay. - RDX metabolites did not have adverse effects on cricket survival, growth, and egg production, but adversely affected egg hatching.

Effects of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) metabolites on cricket (Acheta domesticus) survival and reproductive success

International Nuclear Information System (INIS)

Zhang Baohong; Freitag, Christina M.; Canas, Jaclyn E.; Cheng Qiuqiong; Anderson, Todd A.

2006-01-01

The effect of two major hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) metabolites, hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX) and hexahydro-1,3,5-trinitroso-1,3,5-triazine (TNX), on cricket (Acheta domesticus) survival and reproduction was studied. RDX metabolites did not have adverse effects on cricket survival, growth, and egg production. However, MNX and TNX did affect egg hatching. MNX and TNX were more toxic in spiked-sand than in topical tests. TNX was more toxic to egg than MNX. Developmental stage and exposure time affected hatching. After 30 days exposure to MNX or TNX, the EC 2 , EC 5 , and EC 95 were 47, 128, and 247 μg/g for TNX, and 65, 140, and 253 μg/g for MNX in topical tests. The ECs for 20, 50, and 95 were 21, 52, and 99 μg/g for MNX, and 12, 48, and 97 μg/g for TNX in sand. No gross abnormalities in cricket nypmhs were observed in all experiments indicating that neither TNX or MNX is teratogenic in this assay. - RDX metabolites did not have adverse effects on cricket survival, growth, and egg production, but adversely affected egg hatching

Risk-Association of Five SNPs in TOX3/LOC643714 with Breast Cancer in Southern China

Directory of Open Access Journals (Sweden)

Xuanqiu He

2014-01-01

Full Text Available The specific mechanism by which low-risk genetic variants confer breast cancer risk is currently unclear, with contradictory evidence on the role of single nucleotide polymorphisms (SNPs in TOX3/LOC643714 as a breast cancer susceptibility locus. Investigations of this locus using a Chinese population may indicate whether the findings initially identified in a European population are generalizable to other populations, and may provide new insight into the role of genetic variants in the etiology of breast cancer. In this case-control study, 623 Chinese female breast cancer patients and 620 cancer-free controls were recruited to investigate the role of five SNPs in TOX3/LOC643714 (rs8051542, rs12443621, rs3803662, rs4784227, and rs3112612; Linkage disequilibrium (LD pattern analysis was performed. Additionally, we evaluated how these common SNPs influence the risk of specific types of breast cancer, as defined by estrogen receptor (ER status, progesterone receptor (PR status and human epidermal growth factor receptor 2 (HER2 status. Significant associations with breast cancer risk were observed for rs4784227 and rs8051542 with odds ratios (OR of 1.31 ((95% confidence intervals (CI, 1.10–1.57 and 1.26 (95% CI, 1.02–1.56, respectively, per T allele. The T-rs8051542 allele was significantly associated with ER-positive and HER2-negative carriers. No significant association existed between rs12443621, rs3803662, and rs3112612 polymorphisms and risk of breast cancer. Our results support the hypothesis that the applicability of a common susceptibility locus must be confirmed among genetically different populations, which may together explain an appreciable fraction of the genetic etiology of breast cancer.

1,3,5-Triethylbenzene Transformation Reactions Compared to Its Transalkylation Reaction with Ethylbenzene

KAUST Repository

Akhtar, M. Naseem; Sulaiman, Al Khattaf

2009-01-01

The transalkylation of 1,3,5-triethylbenzene (1,3,5-TEB) with ethylbenzene (EB) has been studied over USYtype catalysts using a riser simulator that mimics the operation of a fluidized-bed reactor. The reaction mixture EB and 1,3,5-TEB was used at a molar ratio of 1:1, which is equivalent to 40:60 wt % of EB/1,3,5-TEB, respectively. The reaction temperature was varied from 350 to 500 °C with a time on stream ranging from 3-15 s. The effect of reaction conditions on 1,3,5-TEB conversion, DEB selectivity, and isomerization of 1,3,5-TEB is reported. The transalkylation of 1,3,5-TEB with EB has been compared to the transformation reaction of pure 1,3,5-TEB and EB. The experimental results have revealed that reactivity of 1,3,5-TEB and selectivity of DEB is increased during the transalkylation reaction (EB + 1,3,5-TEB) as compared to the transformation reaction of pure EB or 1,3,5-TEB. The 1,3,5-TEB undergoes isomerization and a cracking reaction to produce DEB and EB but does not undergo any appreciable disproportionation reaction. The isomerization of 1,3,5-TEB is more active at low temperatures, while cracking is more active at high temperatures. © 2009 American Chemical Society.

1,3,5-Triethylbenzene Transformation Reactions Compared to Its Transalkylation Reaction with Ethylbenzene

KAUST Repository

Akhtar, M. Naseem

2009-08-20

The transalkylation of 1,3,5-triethylbenzene (1,3,5-TEB) with ethylbenzene (EB) has been studied over USYtype catalysts using a riser simulator that mimics the operation of a fluidized-bed reactor. The reaction mixture EB and 1,3,5-TEB was used at a molar ratio of 1:1, which is equivalent to 40:60 wt % of EB/1,3,5-TEB, respectively. The reaction temperature was varied from 350 to 500 °C with a time on stream ranging from 3-15 s. The effect of reaction conditions on 1,3,5-TEB conversion, DEB selectivity, and isomerization of 1,3,5-TEB is reported. The transalkylation of 1,3,5-TEB with EB has been compared to the transformation reaction of pure 1,3,5-TEB and EB. The experimental results have revealed that reactivity of 1,3,5-TEB and selectivity of DEB is increased during the transalkylation reaction (EB + 1,3,5-TEB) as compared to the transformation reaction of pure EB or 1,3,5-TEB. The 1,3,5-TEB undergoes isomerization and a cracking reaction to produce DEB and EB but does not undergo any appreciable disproportionation reaction. The isomerization of 1,3,5-TEB is more active at low temperatures, while cracking is more active at high temperatures. © 2009 American Chemical Society.

Senator Jake Garn on the KC-135

Science.gov (United States)

1985-01-01

Senator Jake Garn appears to be springing from a trampoline in this scene, taken during a brief period of weightlessness provided by a parabola flown by the KC-135. Jeff Bingham, an aide to the senator, floats freely nearby (25616); Sen. Garn and Jeff Bingham prepare to ease from a partially anchored position to a totally free flying mode during a brief weightless session (25617); Sen. Garn gets an initial 'feel' of weightlessness as his feet float freely while he anchors himself with his hands. Seated nearby is his aide Bingham (25618); Sen. Garn (background) shares some of the ceiling space of the KC-135 with Bingham (25619); Sen. Garn (foreground) takes a seat behind the KC-135's crew in the forward cabin. Roger Zweig and Joseph S. Algranti, pilot and co-pilot, are partially visible in the background (25620).

14 CFR 135.158 - Pitot heat indication systems.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Pitot heat indication systems. 135.158... Equipment § 135.158 Pitot heat indication systems. (a) Except as provided in paragraph (b) of this section... instrument pitot heating system unless the airplane is also equipped with an operable pitot heat indication...

Profiling of the Tox21 Chemical Collection for Mitochondrial Function to Identify Compounds that Acutely Decrease Mitochondrial Membrane Potential

Science.gov (United States)

Attene-Ramos, Matias S.; Huang, Ruili; Michael, Sam; Witt, Kristine L.; Richard, Ann; Tice, Raymond R.; Simeonov, Anton; Austin, Christopher P.

2014-01-01

Background: Mitochondrial dysfunction has been implicated in the pathogenesis of a variety of disorders including cancer, diabetes, and neurodegenerative and cardiovascular diseases. Understanding whether different environmental chemicals and druglike molecules impact mitochondrial function represents an initial step in predicting exposure-related toxicity and defining a possible role for such compounds in the onset of various diseases. Objectives: We sought to identify individual chemicals and general structural features associated with changes in mitochondrial membrane potential (MMP). Methods: We used a multiplexed [two end points in one screen; MMP and adenosine triphosphate (ATP) content] quantitative high throughput screening (qHTS) approach combined with informatics tools to screen the Tox21 library of 10,000 compounds (~ 8,300 unique chemicals) at 15 concentrations each in triplicate to identify chemicals and structural features that are associated with changes in MMP in HepG2 cells. Results: Approximately 11% of the compounds (913 unique compounds) decreased MMP after 1 hr of treatment without affecting cell viability (ATP content). In addition, 309 compounds decreased MMP over a concentration range that also produced measurable cytotoxicity [half maximal inhibitory concentration (IC50) in MMP assay/IC50 in viability assay ≤ 3; p Tice RR, Simeonov A, Austin CP, Xia M. 2015. Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential. Environ Health Perspect 123:49–56; http://dx.doi.org/10.1289/ehp.1408642 PMID:25302578

28 CFR 0.135 - Functions common to heads of organizational units.

Science.gov (United States)

2010-07-01

... organizational unit authority and responsibility for the reallotment of such funds and control of obligations and... organizational units. 0.135 Section 0.135 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE... Disqualification to Act § 0.135 Functions common to heads of organizational units. Subject to the general...

24 CFR 17.135 - Procedures for salary offset: types of collection.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Procedures for salary offset: types of collection. 17.135 Section 17.135 Housing and Urban Development Office of the Secretary... the Government Salary Offset Provisions § 17.135 Procedures for salary offset: types of collection. A...

Rola leptyny w regulacji metabolizmu lipidów i węglowodanów

Directory of Open Access Journals (Sweden)

Patrycja Gogga*

2011-01-01

Full Text Available Leptyna jest białkiem wydzielanym głównie przez tkankę tłuszczową, a jej stężenie we krwi jest ściśle związane z ilością zapasów energetycznych zgromadzonych w adipocytach. Jako hormon leptyna ma niezwykle szeroki zakres działania. Białko to bezpośrednio lub za pośrednictwem układu współczulnego bierze udział w regulacji metabolizmu energetycznego. Leptyna hamuje biosyntezę triacylogliceroli w wątrobie i tkance tłuszczowej, a także w mięśniach szkieletowych, obniżając tym samym ilość odkładanych w nich lipidów. W adipocytach leptyna zmniejsza ekspresję genów kodujących syntazę kwasów tłuszczowych (FAS i karboksylazę acetylo-CoA (ACC – główne enzymy szlaku biosyntezy kwasów tłuszczowych. Zwiększa z kolei ekspresję genu kodującego lipazę zależną od hormonów (HSL, co stymuluje hydrolizę triacylogliceroli w tkance tłuszczowej. Ponadto leptyna wzmaga utlenianie kwasów tłuszczowych w adipocytach, mięśniach szkieletowych oraz w mięśniu sercowym, wywołując wzrost ekspresji genów kodujących podstawowe dla tego procesu enzymy, palmitoilotransferazę karnitynową 1 (CPT1 i dehydrogenazę acylo-CoA o średniej długości łańcucha (MCAD. Wykazano również, że hormon ten zwiększa wrażliwość tkanek na insulinę i poprawia tolerancję glukozy – pod wpływem leptyny wzrasta transport glukozy do komórek oraz intensywność glikolizy.Wiadomo, że leptyna bierze udział w długoterminowej regulacji pobierania pokarmu, jednak coraz więcej badań wskazuje, że ma ona również wpływ na przemiany substratów energetycznych w tkankach obwodowych. Leptyna może zatem kontrolować homeostaz�� energetyczną organizmu wywołując zmiany metabolizmu lipidów i węglowodanów, przede wszystkim w tkance tłuszczowej i w mięśniach.

Computer simulations and modeling-assisted ToxR screening in deciphering 3D structures of transmembrane α-helical dimers: ephrin receptor A1

International Nuclear Information System (INIS)

Volynsky, P E; Mineeva, E A; Goncharuk, M V; Ermolyuk, Ya S; Arseniev, A S; Efremov, R G

2010-01-01

Membrane-spanning segments of numerous proteins (e.g. receptor tyrosine kinases) represent a novel class of pharmacologically important targets, whose activity can be modulated by specially designed artificial peptides, the so-called interceptors. Rational construction of such peptides requires understanding of the main factors driving peptide–peptide association in lipid membranes. Here we present a new method for rapid prediction of the spatial structure of transmembrane (TM) helix–helix complexes. It is based on computer simulations in membrane-like media and subsequent refinement/validation of the results using experimental studies of TM helix dimerization in a bacterial membrane by means of the ToxR system. The approach was applied to TM fragments of the ephrin receptor A1 (EphA1). A set of spatial structures of the dimer was proposed based on Monte Carlo simulations in an implicit membrane followed by molecular dynamics relaxation in an explicit lipid bilayer. The resulting models were employed for rational design of wild-type and mutant genetic constructions for ToxR assays. The computational and the experimental data are self-consistent and provide an unambiguous spatial model of the TM dimer of EphA1. The results of this work can be further used to develop new biologically active 'peptide interceptors' specifically targeting membrane domains of proteins

46 CFR 45.135 - Hull openings at or below freeboard deck.

Science.gov (United States)

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Hull openings at or below freeboard deck. 45.135 Section 45.135 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES GREAT LAKES LOAD LINES Conditions of Assignment § 45.135 Hull openings at or below freeboard deck. Closures for hull...

135La as an auger-electron emitter for targeted internal radiotherapy

DEFF Research Database (Denmark)

Fonslet, Jesper; Lee, Boon Quan; Tran, Thuy A.

2018-01-01

Introduction: 135La has favorable nuclear and chemical properties for Auger-based targeted internal radiotherapy. Here we present detailed investigations of the production, emissions, imaging characteristics, and dosimetry related to 135La therapy. Methods and Results: 135La was produced by 16.5 Me....... The generated Auger spectrum was used to recalculate cellular S-factors. Conclusion: 135La was produced with high specific activity, reactivity, radionuclidic purity, and yield. The emission spectrum and the dosimetry are favorable for internal radionuclide therapy. ....... recovered > 98 % of the 135La with an effective molar activity of 70 ±20 GBq/µmol. To better assess cellular and organ dosimetry of this nuclide, we have recalculated the X-ray and Auger emission spectra using a Monte Carlo model accounting for effects of multiple vacancies during the Auger cascade...

22 CFR 135.20 - Standards for financial management systems.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Standards for financial management systems. 135... Financial Administration § 135.20 Standards for financial management systems. (a) A State must expand and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees must...

InAs(PSb)-based ``W'' quantum well laser diodes emitting near 3.3 μm

Science.gov (United States)

Joullié, A.; Skouri, E. M.; Garcia, M.; Grech, P.; Wilk, A.; Christol, P.; Baranov, A. N.; Behres, A.; Kluth, J.; Stein, A.; Heime, K.; Heuken, M.; Rushworth, S.; Hulicius, E.; Simecek, T.

2000-05-01

Mid-infrared laser diodes with an active region consisting of five "W" InAsSb/InAsP/InAsSb/InAsPSb quantum wells and broad InAsPSb waveguide were fabricated by metalorganic vapor phase epitaxy on InAs substrates. Laser emission was demonstrated at 3.3 μm up to 135 K from asymmetrical structures having n-type InAsPSb and p-type InPSb cladding layers. The devices operated in pulsed regime at 3.3 μm, with a lowest threshold current density of 120 A/cm2 at 90 K, and an output power efficiency of 31 mW/facet/A. The characteristic temperature was 35 K.

19 CFR 122.135 - When airline has in-bond liquor storeroom.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false When airline has in-bond liquor storeroom. 122.135 Section 122.135 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Liquor Kits § 122.135 When airline has in-bond liquor storeroom. (a) Restocking. Liquor...

Survey of the small (300 W to 300 kW) wind turbine market in Canada

International Nuclear Information System (INIS)

2005-01-01

The significant growth in the Canadian wind power industry over the past decade has resulted in an increased number of large utility-scale wind farms appearing across Canada. Although large wind turbines are often acknowledged as a mature technology that can provide clean, reliable and economically competitive power, smaller wind turbines have had relatively little documentation in comparison. The aim of this report was to provide a profile of the Canadian market for small wind turbines (SWTs), divided into 3 categories: mini wind turbines with a rated power output from 300 watts to 1000 watts; small wind turbines up to 30 kW; and medium-sized wind turbines up to 300 kW. Study findings were based on interviews with industry experts and a comprehensive survey of 135 companies involved in the Canadian SWT industry. Details of annual sales and total installed capacity were provided, as well as a summary of key SWT markets. An overview of Canadian market demand and international SWT manufacturing capacity was presented. Opportunities and barriers were examined. It was observed that experiences in the United States have indicated that SWTs are more successful when combined with enabling policies, market incentives, and education and awareness raising. The U.S. small wind industry has estimated that in the near future, the SWT industry could supply 50,000 MW, employ 10,000 people and generate $1 billion per year. A number of opportunities for the promotion of the small wind industry in Canada were reviewed, including the niche manufacturing sector in the 20 kW to 50 kW range. Issues concerning the economic benefits of a SWT manufacturing industry were examined. It was suggested that as the SWT markets grow and mature, turbine prices are expected to fall and turbine effectiveness and reliability will increase. An SWT promotional strategy was outlined with incentives in 4 areas: (1) market development; (2) policy development; (3) technology development; and (4) education

Characterization of ToxCast Phase II compounds disruption of ...

Science.gov (United States)

The development of multi-well microelectrode array (mwMEA) systems has increased in vitro screening throughput making them an effective method to screen and prioritize large sets of compounds for potential neurotoxicity. In the present experiments, a multiplexed approach was used to determine compound effects on both neural function and cell health in primary cortical networks grown on mwMEA plates following exposure to ~1100 compounds from EPA’s Phase II ToxCast libraries. On DIV 13, baseline activity (40 min) was recorded prior to exposure to each compound at 40 µM. DMSO and the GABAA antagonist bicuculline (BIC) were included as controls on each mwMEA plate. Changes in spontaneous network activity (mean firing rate; MFR) and cell viability (lactate dehydrogenase; LDH and CellTiter Blue; CTB) were assessed within the same well following compound exposure. Activity calls (“hits”) were established using the 90th and 20th percentiles of the compound-induced change in MFR (medians of triplicates) across all tested compounds; compounds above (top 10% of compounds increasing MFR), and below (bottom 20% of compounds decreasing MFR) these thresholds, respectively were considered hits. MFR was altered beyond one of these thresholds by 322 compounds. Four compound categories accounted for 66% of the hits, including: insecticides (e.g. abamectin, lindane, prallethrin), pharmaceuticals (e.g. haloperidol, reserpine), fungicides (e.g. hexaconazole, fenamidone), and h

14 CFR 135.167 - Emergency equipment: Extended overwater operations.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Emergency equipment: Extended overwater operations. 135.167 Section 135.167 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF...) One CO2 bottle for emergency inflation; (x) One inflation pump; (xi) Two oars; (xii) One 75-foot...

10 CFR 600.135 - Supplies and other expendable property.

Science.gov (United States)

2010-01-01

... acquisition. If there is a residual inventory of unused supplies exceeding $5000 in total aggregate value upon... 10 Energy 4 2010-01-01 2010-01-01 false Supplies and other expendable property. 600.135 Section... Education, Hospitals, and Other Nonprofit Organizations Post-Award Requirements § 600.135 Supplies and other...

Probing the W chromosome of the codling moth, Cydia pomonella, with sequences from microdissected sex chromatin

Czech Academy of Sciences Publication Activity Database

Vrbová, Iva; Traut, W.; Vítková, Magda; Nguyen, Petr; Kubíčková, S.; Marec, František

2007-01-01

Roč. 116, č. 2, (2007), s. 135-145 ISSN 0009-5915 R&D Projects: GA ČR(CZ) GA206/06/1860; GA ČR GD521/03/H160; GA AV ČR IAA6007307 Grant - others:International Atomic Energy Agency(AT) 12055/R Institutional research plan: CEZ:AV0Z50070508 Keywords : W chromosome Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 4.337, year: 2007

33 CFR 135.215 - Certification.

Science.gov (United States)

2010-07-01

... partnership applicant, or a director or other officer of a corporate applicant. (d) Financial data or other...) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND Financial Responsibility for Offshore Facilities § 135.215 Certification. (a) Applicants shall: (1) If the...

77 FR 71605 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2012-12-03

... Hersh, Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville... Analytics Inc., NOVAMANN (Ontario), Inc.) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN...

77 FR 32653 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2012-06-01

... Hersh, Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville... Analytics Inc., NOVAMANN (Ontario), Inc.). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN...

14 CFR 135.89 - Pilot requirements: Use of oxygen.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Pilot requirements: Use of oxygen. 135.89... Operations § 135.89 Pilot requirements: Use of oxygen. (a) Unpressurized aircraft. Each pilot of an... operated with the cabin pressure altitude more than 10,000 feet MSL, each pilot shall comply with paragraph...

14 CFR 135.113 - Passenger occupancy of pilot seat.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Passenger occupancy of pilot seat. 135.113... Operations § 135.113 Passenger occupancy of pilot seat. No certificate holder may operate an aircraft type certificated after October 15, 1971, that has a passenger seating configuration, excluding any pilot seat, of...

33 CFR 135.1 - Purpose.

Science.gov (United States)

2010-07-01

... FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND General § 135.1 Purpose... oil pollution liability and compensation, including the administration and general operation of the fund established under Title III of the Outer Continental Shelf Lands Act Amendments of 1978 (Pub. L...

21 CFR 135.110 - Ice cream and frozen custard.

Science.gov (United States)

2010-04-01

...) of this section, the name of the food is “frozen custard” or “french ice cream” or “french custard... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Ice cream and frozen custard. 135.110 Section 135.110 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

IM-135-648-00 IDIM tester instruction manual for the TESTER for (135 to 562) Isolated Digital Input Module for SLC

International Nuclear Information System (INIS)

Kieffer, J.

1983-01-01

This unit is designed to provide all of the input levels and channels needed to perform complete production and maintenance testing of the SLC Isolated Digital Input Module (SLAC 135 to 562). The manual includes the following sections: specifications; front panel, lights and connectors; reference list; functional description; 82S100 logic equations; test and checkout procedures; appendix A, SLAC 82S100 programming data; and appendix B, JXK-FORTH 135 to 648 program listing

40 CFR 1042.135 - Labeling.

Science.gov (United States)

2010-07-01

... EMISSIONS FROM NEW AND IN-USE MARINE COMPRESSION-IGNITION ENGINES AND VESSELS Emission Standards and Related Requirements § 1042.135 Labeling. (a) Assign each engine a unique identification number and permanently affix... engine family is certified (such as constant-speed auxiliary, variable-speed propulsion engines used with...

Zmiany w nierównościach edukacyjnych w Polsce. Uwagi polemiczne do tekstu Zbigniewa Sawińskiego „Gimnazja wobec nierówności społecznych”

Directory of Open Access Journals (Sweden)

Michał Sitek

2016-06-01

Full Text Available Zbigniew Sawiński w tekście opublikowanym w EDUKACJI („Gimnazja wobec nierówności społecznych”, Edukacja, 135(4, 2015 twierdzi na podstawie analiz danych programu OECD PISA z lat 2000–2012, że reforma gimnazjalna nie spowodowała zmniejszenia nierówności w polskiej edukacji: znaczenie pochodzenia społecznego dla osiągnięć uczniów utrzymywało się na podobnym poziomie jak przed reformą, nie zmniejszył się znacząco wpływ pochodzenia społecznego na wybór szkoły średniej, a obserwowane w Polsce różnicowanie się gimnazjów nie doprowadziło do wzrostu nierówności edukacyjnych. W artykule przedstawiono argumenty metodologiczne i wyniki powtórnej analizy danych PISA wskazujące na zmiany w szerzej rozumianych nierównościach edukacyjnych. Między 2000 a 2012 r. (a nie zmieniła się wprawdzie siła związku wyników osiąganych przez piętnastolatków ze statusem społeczno-ekonomicznym rodzin uczniów, ale: (b zmniejszyło się zróżnicowanie wyników, co było przede wszystkim zasługą poprawy wyników najsłabszych uczniów; (c zmniejszyły się różnice między uczniami o niskim i wysokim statusie społeczno-ekonomicznym; (d zmniejszył się wpływ pochodzenia społecznego na wybór szkoły ponadgimnazjalnej. Wpływ ten jest w dużej mierze bezpośredni: nie jest zapośredniczony przez osiągnięcia edukacyjne uczniów. W polemice podkreślono także złożoność tzw. reformy gimnazjalnej, która nie ograniczyła się jedynie do wprowadzenia gimnazjów. Wskazano na rolę innych czynników, które utrudniają analizowanie efektów reformy gimnazjalnej w kategoriach przyczynowo-skutkowych, w tym przede wszystkim na rolę nieobserwowanych w badaniu PISA zmiennych dotyczących zmian zachodzących w środowisku uczenia się kolejnych kohort uczestniczących w badaniu.

76 FR 40924 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2011-07-12

..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857...., NOVAMANN (Ontario), Inc.). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636...

76 FR 31969 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2011-06-02

..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857...., NOVAMANN (Ontario), Inc.). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636...

76 FR 161 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2011-01-03

..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... certification maintenance program. MedTox Laboratories, Inc., 402 W. County Road D,St. Paul, MN 55112. 651-636...

77 FR 26022 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2012-05-02

..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857...., NOVAMANN (Ontario), Inc.). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636...

77 FR 5037 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2012-02-01

..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857...., NOVAMANN (Ontario), Inc.); MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636...

77 FR 20832 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2012-04-06

..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857...., NOVAMANN (Ontario), Inc.). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636...

77 FR 54597 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2012-09-05

..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857...., NOVAMANN (Ontario), Inc.). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636...

32 CFR 13.5 - Policies.

Science.gov (United States)

2010-07-01

... Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS RESPONSIBILITIES OF THE CHIEF DEFENSE COUNSEL, DETAILED DEFENSE COUNSEL, AND CIVILIAN DEFENSE COUNSEL § 13.5 Policies. (a) Prohibition.... Personnel assigned to the Office of the Chief Defense Counsel, as well as all members of the Civilian...

33 CFR 135.5 - Definitions.

Science.gov (United States)

2010-07-01

... FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND General § 135.5...”; “claim”; “discharge”; “facility”; “Fund”; “guarantor”; “incident”; “offshore facility”; “oil pollution...), entitled “Offshore Oil Spill Pollution Fund”. (2) Captain of the Port means a Coast Guard officer...

Developmental Effects of the ToxCast™ Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits

Science.gov (United States)

Boyd, Windy A.; Smith, Marjolein V.; Co, Caroll A.; Pirone, Jason R.; Rice, Julie R.; Shockley, Keith R.; Freedman, Jonathan H.

2015-01-01

Background: Modern toxicology is shifting from an observational to a mechanistic science. As part of this shift, high-throughput toxicity assays are being developed using alternative, nonmammalian species to prioritize chemicals and develop prediction models of human toxicity. Methods: The nematode Caenorhabditis elegans (C. elegans) was used to screen the U.S. Environmental Protection Agency’s (EPA’s) ToxCast™ Phase I and Phase II libraries, which contain 292 and 676 chemicals, respectively, for chemicals leading to decreased larval development and growth. Chemical toxicity was evaluated using three parameters: a biologically defined effect size threshold, half-maximal activity concentration (AC50), and lowest effective concentration (LEC). Results: Across both the Phase I and Phase II libraries, 62% of the chemicals were classified as active ≤ 200 μM in the C. elegans assay. Chemical activities and potencies in C. elegans were compared with those from two zebrafish embryonic development toxicity studies and developmental toxicity data for rats and rabbits. Concordance of chemical activity was higher between C. elegans and one zebrafish assay across Phase I chemicals (79%) than with a second zebrafish assay (59%). Using C. elegans or zebrafish to predict rat or rabbit developmental toxicity resulted in balanced accuracies (the average value of the sensitivity and specificity for an assay) ranging from 45% to 53%, slightly lower than the concordance between rat and rabbit (58%). Conclusions: Here, we present an assay that quantitatively and reliably describes the effects of chemical toxicants on C. elegans growth and development. We found significant overlap in the activity of chemicals in the ToxCast™ libraries between C. elegans and zebrafish developmental screens. Incorporating C. elegans toxicological assays as part of a battery of in vitro and in vivo assays provides additional information for the development of models to predict a chemical�

13 CFR 113.135 - Designation of responsible employee and adoption of grievance procedures.

Science.gov (United States)

2010-01-01

... employee and adoption of grievance procedures. 113.135 Section 113.135 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NONDISCRIMINATION IN FINANCIAL ASSISTANCE PROGRAMS OF SBA-EFFECTUATION OF POLICIES... Programs or Activities Receiving Federal Financial Assistance Introduction § 113.135 Designation of...

76 FR 75889 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2011-12-05

..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... (Ontario), Inc.). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, (651) 636-7466/(800...

78 FR 14100 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2013-03-04

..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... Laboratory Services, a Division of LabOne, Inc.,) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul...

75 FR 45128 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

Science.gov (United States)

2010-08-02

.../CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857; 240-276-2600 (voice), 240-276-2610... Analytics Inc., NOVAMANN (Ontario), Inc.) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN...

77 FR 126 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2012-01-03

..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857....). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, (651) 636-7466/(800) 832-3244...

The impact of co-combustion of polyethylene plastics and wood in a small residential boiler on emissions of gaseous pollutants, particulate matter, PAHs and 1,3,5- triphenylbenzene.

Science.gov (United States)

Tomsej, Tomas; Horak, Jiri; Tomsejova, Sarka; Krpec, Kamil; Klanova, Jana; Dej, Milan; Hopan, Frantisek

2018-04-01

The aim of this study was to simulate a banned but widely spread practice of co-combustion of plastic with wood in a small residential boiler and to quantify its impact on emissions of gaseous pollutants, particulate matter (PM), polycyclic aromatic hydrocarbons (PAHs), and 1,3,5-triphenylbenzene (135TPB), a new tracer of polyethylene plastic combustion. Supermarket polyethylene shopping bags (PE) and polyethylene terephthalate bottles (PET) were burnt as supplementary fuels with beech logs (BL) in an old-type 20 kW over-fire boiler both at a nominal and reduced heat output. An impact of co-combustion was more pronounced at the nominal heat output: an increase in emissions of PM, total organic carbon (TOC), toxic equivalent (TEQ) of 7 carcinogenic PAHs (c-PAHs) and a higher ratio of c-PAHs TEQ in particulate phase was observed during co-combustion of both plastics. 135TPB was found in emissions from both plastics both at a nominal and reduced output. In contrast to findings reported in the literature, 135TPB was a dominant compound detected by mass spectrometry on m/z 306 exclusively in emissions from co-combustion of PE. Surprisingly, six other even more abundant compounds of unknown identity were found on this m/z in emissions from co-combustion of PET. One of these unknown compounds was identified as p-quaterphenyl (pQ). Principal component analysis revealed strong correlation among 135TPB, pQ and five unknown compounds. pQ seems to be suitable tracers of polyethylene terephthalate plastic co-combustion, while 135TPB proved its suitability to be an all-purpose tracer of polyethylene plastics combustion. Copyright © 2017 Elsevier Ltd. All rights reserved.

Determination of {sup 135}Cs by accelerator mass spectrometry

Energy Technology Data Exchange (ETDEWEB)

MacDonald, C.M.; Charles, C.R.J. [Andre. E. Lalonde AMS Laboratory, University of Ottawa, 150 Louis Pasteur, Ottawa, ON K1N 6N5 (Canada); Department of Earth Sciences, University of Ottawa, 150 Louis Pasteur, Ottawa, ON K1N 6N5 (Canada); Zhao, X.-L.; Kieser, W.E. [Andre. E. Lalonde AMS Laboratory, University of Ottawa, 150 Louis Pasteur, Ottawa, ON K1N 6N5 (Canada); Department of Physics, University of Ottawa, 150 Louis Pasteur, Ottawa, ON K1N 6N5 (Canada); Cornett, R.J. [Andre. E. Lalonde AMS Laboratory, University of Ottawa, 150 Louis Pasteur, Ottawa, ON K1N 6N5 (Canada); Department of Earth Sciences, University of Ottawa, 150 Louis Pasteur, Ottawa, ON K1N 6N5 (Canada); Litherland, A.E. [IsoTrace Laboratory, University of Toronto, 60 St. George St., Toronto, ON M5S 1A7 (Canada)

2015-10-15

The ratio of anthropogenic {sup 135}Cs and {sup 137}Cs isotopes is characteristic of a uranium fission source. This research evaluates the technique of isotope dilution (yield tracing) for the purpose of quantifying {sup 135}Cs by accelerator mass spectrometry with on-line isobar separation. Interferences from Ba, Zn{sub 2}, and isotopes of equal mass to charge ratios were successfully suppressed. However, some sample crosstalk from source contamination remains. The transmission and di-fluoride ionization efficiencies of Cs isotopes were found to be 8 × 10{sup −3} and 1.7 × 10{sup −7} respectively. This quantification of {sup 135}Cs using yield tracing by accelerator mass spectrometry shows promise for future environmental sample analysis once the issues of sample crosstalk and low efficiency can be resolved.

O período toxêmico da esquistossomose

Directory of Open Access Journals (Sweden)

J. Leocádio

1969-06-01

Full Text Available O A. apresenta seis casos de pacientes observados durante o período toxêmico da esquistosomose mansônica. Dêstes, um foi de mulher cuja sintomatologia datava de um ano. Concebeu e deu à luz durante a enfermidade. Apresentava sinais de fibrose hepática quando do primeiro exame, ainda na vigência de sintomas do período agudo da enfermidade. Todos êstes pacientes apresentavam febre, dores abdominais, hepatoesplenomegalia e outras manifestações que têm sido descritas neste período da parasitose. Como notas dominantes no hemograma, leucocitose com eosinofilia, como ocorre nas infecções por helmintos com ciclo textrino, e anemia. Esta, nem todos apresentavam. Além de alterações do equilíbrio proteico e de resultados da exploração funcional do fígado, o A. chamou a atenção para a hípoglicemia e hipocolesterolemia encontradas em alguns dos observados. Foi digno de registro, também, a positividade tardia da intradermorreação para diagnóstico da esquistosomose. Todos os pacientes foram submetidos a tratamento antimonial, com bom resultado. Como reação colateral devemos mencionar a exacerbação da febre forçando, por vêzes à interrupção do mesmo. O A. faz referências a outros recursos terapêuticos empregados no Oriente: o F30.066, um nitrofurano de uso oral, e as sementes de Cucurbita moshata. Sugere a investigação em animais e no homem com sementes de abóbora outrora empregadas como tenifugo

77 FR 69642 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2012-11-20

..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... (Ontario), Inc.) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832...

75 FR 5088 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

Science.gov (United States)

2010-02-01

.../CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857; 240-276-2600 (voice), 240-276-2610...., NOVAMANN (Ontario), Inc.). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636...

76 FR 24501 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2011-05-02

..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... (Ontario), Inc.) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832...

76 FR 6147 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2011-02-03

..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857....) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112. 651-636-7466/800-832-3244. Metro...

78 FR 33429 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2013-06-04

..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857....). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832-3244. Metro...

76 FR 46309 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2011-08-02

..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... (Ontario), Inc.) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832...

78 FR 72684 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2013-12-03

... INFORMATION CONTACT: Giselle Hersh, Division of Workplace Programs, SAMHSA/CSAP, Room 7-1051, One Choke Cherry..., a Division of LabOne, Inc.) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651...

78 FR 59946 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2013-09-30

... INFORMATION CONTACT: Giselle Hersh, Division of Workplace Programs, SAMHSA/CSAP, Room 7-1051, One Choke Cherry....). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832-3244. Metro...

75 FR 75485 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

Science.gov (United States)

2010-12-03

..., Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857; 240-276-2600 (voice), 240-276-2610 (fax...., NOVAMANN (Ontario), Inc.). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112. 651-636...

75 FR 62842 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

Science.gov (United States)

2010-10-13

..., Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857; 240-276-2600 (voice), 240-276-2610 (fax...., NOVAMANN (Ontario), Inc.) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466...

135La as an Auger-electron emitter for targeted internal radiotherapy

Science.gov (United States)

Fonslet, J.; Lee, B. Q.; Tran, T. A.; Siragusa, M.; Jensen, M.; Kibédi, T.; E Stuchbery, A.; Severin, G. W.

2018-01-01

135La has favorable nuclear and chemical properties for Auger-based targeted internal radiotherapy. Here we present detailed investigations of the production, emissions, and dosimetry related to 135La therapy. 135La was produced by 16.5 MeV proton irradiation of metallic natBa on a medical cyclotron, and was isolated and purified by trap-and-release on weak cation-exchange resin. The average production rate was 407  ±  19 MBq µA-1 (saturation activity), and the radionuclidic purity was 98% at 20 h post irradiation. Chemical separation recovered  >  98 % of the 135La with an effective molar activity of 70  ±  20 GBq µmol-1. To better assess cellular and organ dosimetry of this nuclide, we have calculated the x-ray and Auger emission spectra using a Monte Carlo model accounting for effects of multiple vacancies during the Auger cascade. The generated Auger spectrum was used to calculate cellular S-factors. 135La was produced with high specific activity, reactivity, radionuclidic purity, and yield. The emission spectrum and the dosimetry are favorable for internal radionuclide therapy.

Water quality criteria for hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

Energy Technology Data Exchange (ETDEWEB)

Etnier, E.L.

1989-04-01

The occurrence of the munitions compound hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in groundwater surrounding Army ammunition plants may result in contamination of local drinking water supplies. RDX exerts its primary toxic effect in humans on the central nervous system, but also involves gastrointestinal and renal effects. Symptomatic effects following acute exposure include hyperirritability, nausea, vomiting, generalized epileptiform seizures, and prolonged postictal confusion and amnesia. Health effects data were analyzed for RDX, and although no controlled human studies exist concerning the acute or chronic toxic effects of exposure to RDX, sufficient animal toxicity data are available to derive an ambient water quality criterion for the protection of human health. This paper summarizes the available literature on metabolism of RDX and human and animal toxicity. Based on noncarcinogenic mammalian toxicity data, and following the methodologies of the U.S. Environmental Protection Agency, an ambient water quality criterion for the protection of human health of 103 micrograms/liter is proposed for ingestion of drinking water and aquatic foodstuffs. A criterion of 105 micrograms/liter is proposed for ingestion of drinking water alone.54 references.

Miejsce muzeów w turystyce kulturowej w Polsce

OpenAIRE

Krakowiak, Beata

2013-01-01

The article presents the museums, their potential and their significance for cultural tourism in Poland. Its aims are achieved through a presentation of registered national museums, ‘monuments of history’, museum buildings and the cultural activities undertaken by these institutions Artykuł dotyczy potencjału muzealnego oraz jego znaczenia dla turystyki kulturowej w Polsce. Zamierzone cele pracy realizowane są poprzez prezentację muzeów rejestrowanych, narodowych, muzeów-pomników histor...

78 FR 46996 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

Science.gov (United States)

2013-08-02

..., Room 7-1051, One Choke Cherry Road, Rockville, Maryland 20857; 240-276-2600 (voice), 240-276-2610 (fax....) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832-3244 Metro...

75 FR 9229 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

Science.gov (United States)

2010-03-01

.../CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857; 240-276-2600 (voice), 240-276-2610... (Ontario), Inc.) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832...

Angiogeneza w reumatoidalnym zapaleniu stawów

Directory of Open Access Journals (Sweden)

Anna Kotulska

2011-02-01

Full Text Available Angiogeneza jest procesem powstawania nowych włosowatychnaczyń krwionośnych z uprzednio istniejących włośniczek. Angiogenezawystępuje w życiu pozapłodowym i jest regulowana przezzespół czynników proangiogennych i antyangiogennych (tab. I.Zwiększona angiogeneza towarzyszy kilku stanom chorobowym. Jestniezbędna dla wzrostu nowotworów złośliwych. Choroby nienowotworowe,w tym reumatoidalne zapalenie stawów, są także związanez nasiloną angiogenezą. Wykazano tworzenie nowych naczyńw zmienionej zapalnie błonie maziowej stawów, co jest najważniejszązmianą patologiczną u chorych na reumatoidalne zapalenie stawów.U chorych stwierdzono zaburzoną regulację czynników proangiogennychi hamujących ten proces. Leki hamujące zapalenie błonymaziowej bezpośrednio lub pośrednio ograniczają angiogenezę.Możliwe jest, że oddziaływanie na proces angiogenezy będzie stanowićjeden z mechanizmów terapeutycznych leków stosowanychu chorych na reumatoidalne zapalenie stawów.

A 205 Hour Krypton Propellant Life Test of the SPT-100 Operating at 3 kW

Science.gov (United States)

2013-09-01

nominal xenon condition (1.35 kW), tests have validated the SPT -100 life time as exceeding 2.71 million N -s (equivalent to approximately 9,000 hours of...condition – If correlation between erosion and energy throughput holds, SPT may be able to endure • Long term life test would be required to validate Kr as...shift (to zero center of SPT at r = 0) • Small rotation to correct for linear stage sag DISTRIBUTION A: Approved for public release; distribution

14 CFR 135.183 - Performance requirements: Land aircraft operated over water.

Science.gov (United States)

2010-01-01

... operated over water. 135.183 Section 135.183 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... AND OPERATIONS OPERATING REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS... operated over water. No person may operate a land aircraft carrying passengers over water unless— (a) It is...

14 CFR 135.23 - Manual contents.

Science.gov (United States)

2010-01-01

... AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT General § 135.23 Manual... this section, to assist each crewmember and person performing or directly supervising the following job... Analysis establishing runway safety margins at destination airports, taking into account the following...

Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage.

Directory of Open Access Journals (Sweden)

Jui-Hua Hsieh

Full Text Available Cytotoxicity is a commonly used in vitro endpoint for evaluating chemical toxicity. In support of the U.S. Tox21 screening program, the cytotoxicity of ~10K chemicals was interrogated at 0, 8, 16, 24, 32, & 40 hours of exposure in a concentration dependent fashion in two cell lines (HEK293, HepG2 using two multiplexed, real-time assay technologies. One technology measures the metabolic activity of cells (i.e., cell viability, glo while the other evaluates cell membrane integrity (i.e., cell death, flor. Using glo technology, more actives and greater temporal variations were seen in HEK293 cells, while results for the flor technology were more similar across the two cell types. Chemicals were grouped into classes based on their cytotoxicity kinetics profiles and these classes were evaluated for their associations with activity in the Tox21 nuclear receptor and stress response pathway assays. Some pathways, such as the activation of H2AX, were associated with the fast-responding cytotoxicity classes, while others, such as activation of TP53, were associated with the slow-responding cytotoxicity classes. By clustering pathways based on their degree of association to the different cytotoxicity kinetics labels, we identified clusters of pathways where active chemicals presented similar kinetics of cytotoxicity. Such linkages could be due to shared underlying biological processes between pathways, for example, activation of H2AX and heat shock factor. Others involving nuclear receptor activity are likely due to shared chemical structures rather than pathway level interactions. Based on the linkage between androgen receptor antagonism and Nrf2 activity, we surmise that a subclass of androgen receptor antagonists cause cytotoxicity via oxidative stress that is associated with Nrf2 activation. In summary, the real-time cytotoxicity screen provides informative chemical cytotoxicity kinetics data related to their cytotoxicity mechanisms, and with our

14 CFR Appendix B to Part 135 - Airplane Flight Recorder Specifications

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Airplane Flight Recorder Specifications B Appendix B to Part 135 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION.... B Appendix B to Part 135—Airplane Flight Recorder Specifications Parameters Range Installed system 1...

22 CFR 135.22 - Allowable costs.

Science.gov (United States)

2010-04-01

... Procedures, or uniform cost accounting standards that comply with cost principles acceptable to the Federal... AGREEMENTS TO STATE AND LOCAL GOVERNMENTS Post-Award Requirements Financial Administration § 135.22 Allowable... principles. For each kind of organization, there is a set of Federal principles for determining allowable...

78 FR 63570 - Proposed Collection; Comment Request for Forms W-8BEN, W-8BEN-E, W-8ECI, W-8EXP, and W-8IMY

Science.gov (United States)

2013-10-24

... W-8BEN, W-8BEN-E, W-8ECI, W-8EXP, and W-8IMY AGENCY: Internal Revenue Service (IRS), Treasury..., the IRS is soliciting comments concerning Form W-8BEN, Certificate of Foreign Status of Beneficial Owner for United States Tax Withholding, Form W-8BEN-E, Certificate of Status of Beneficial Owner for...

miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERRα.

Science.gov (United States)

Tribollet, Violaine; Barenton, Bruno; Kroiss, Auriane; Vincent, Séverine; Zhang, Ling; Forcet, Christelle; Cerutti, Catherine; Périan, Séverine; Allioli, Nathalie; Samarut, Jacques; Vanacker, Jean-Marc

2016-01-01

MicroRNA-135a (miR-135a) down-modulates parameters of cancer progression and its expression is decreased in metastatic breast cancers (as compared to non-metastatic tumors) as well as in prostate tumors relative to normal tissue. These expression and activity patterns are opposite to those of the Estrogen-Related Receptor α (ERRα), an orphan member of the nuclear receptor family. Indeed high expression of ERRα correlates with poor prognosis in breast and prostate cancers, and the receptor promotes various traits of cancer aggressiveness including cell invasion. Here we show that miR-135a down-regulates the expression of ERRα through specific sequences of its 3'UTR. As a consequence miR-135a also reduces the expression of downstream targets of ERRα. miR-135a also decreases cell invasive potential in an ERRα-dependent manner. Our results suggest that the decreased expression of miR-135a in metastatic tumors leads to elevated ERRα expression, resulting in increased cell invasion capacities.

Firmy rodzinne w Polsce w dobie globalizacji

OpenAIRE

Zalewska, Agnieszka

2016-01-01

Celem publikacji jest ukazanie dorobku naukowego, głównie polskich i ukraińskich uczonych, w zakresie uwarunkowań procesów i rezultatów internacjonalizacji przedsiębiorstw oraz jej wpływu na funkcjonowanie biznesu w dobie globalizacji. Opracowanie stanowi istotny wkład w zakresie teorii i praktyki w proces restrukturyzacji przedsiębiorstw w kierunku ich internacjonalizacji. Może posłużyć jako inspiracja do stworzenia strategii opartej na poszukiwaniach (prospector strategy), co będzie sprzyja...

Lectures on W algebras and W gravity

International Nuclear Information System (INIS)

Pope, C.N.

1992-01-01

We give a review of the extended conformal algebras, known as W algebras, which contain currents of spins higher than 2 in addition to the energy-momentum tensor. These include the non-linear W N algebras; the linear W ∞ and W 1+∞ algebras; and their super-extensions. We discuss their applications to the construction of W-gravity and W-string theories. (author). 46 refs

29 CFR Appendix A to Subpart W to... - Figures W-14 through W-28

Science.gov (United States)

2010-07-01

... 29 Labor 8 2010-07-01 2010-07-01 false Figures W-14 through W-28 A Appendix A to Subpart W to part 1926 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION...; Overhead Protection Pt. 1926, Subpt. W, App. A Appendix A to Subpart W to part 1926—Figures W-14 through W...

Determination of "1"3"5Cs by accelerator mass spectrometry

International Nuclear Information System (INIS)

MacDonald, C.M.; Charles, C.R.J.; Zhao, X.-L.; Kieser, W.E.; Cornett, R.J.; Litherland, A.E.

2015-01-01

The ratio of anthropogenic "1"3"5Cs and "1"3"7Cs isotopes is characteristic of a uranium fission source. This research evaluates the technique of isotope dilution (yield tracing) for the purpose of quantifying "1"3"5Cs by accelerator mass spectrometry with on-line isobar separation. Interferences from Ba, Zn_2, and isotopes of equal mass to charge ratios were successfully suppressed. However, some sample crosstalk from source contamination remains. The transmission and di-fluoride ionization efficiencies of Cs isotopes were found to be 8 × 10"−"3 and 1.7 × 10"−"7 respectively. This quantification of "1"3"5Cs using yield tracing by accelerator mass spectrometry shows promise for future environmental sample analysis once the issues of sample crosstalk and low efficiency can be resolved.

Mitotic phosphorylation of VCIP135 blocks p97ATPase-mediated Golgi membrane fusion

Energy Technology Data Exchange (ETDEWEB)

Totsukawa, Go; Matsuo, Ayaka; Kubota, Ayano; Taguchi, Yuya; Kondo, Hisao, E-mail: hk228@med.kyushu-u.ac.jp

2013-04-05

Highlights: •VCIP135 is mitotically phosphorylated on Threonine-760 and Serine-767 by Cdc2. •Phosphorylated VCIP135 does not bind to p97ATPase. •The phosphorylation of VCIP135 inhibits p97ATPase-mediated Golgi membrane fusion. -- Abstract: In mammals, the Golgi apparatus is disassembled early mitosis and reassembled at the end of mitosis. For Golgi disassembly, membrane fusion needs to be blocked. Golgi biogenesis requires two distinct p97ATPase-mediated membrane fusion, the p97/p47 and p97/p37 pathways. We previously reported that p47 phosphorylation on Serine-140 and p37 phosphorylation on Serine-56 and Threonine-59 result in mitotic inhibition of the p97/p47 and the p97/p37 pathways, respectively [11,14]. In this study, we show another mechanism of mitotic inhibition of p97-mediated Golgi membrane fusion. We clarified that VCIP135, an essential factor in both p97 membrane fusion pathways, is phosphorylated on Threonine-760 and Serine-767 by Cdc2 at mitosis and that this phosphorylated VCIP135 does not bind to p97. An in vitro Golgi reassembly assay revealed that VCIP135(T760E, S767E), which mimics mitotic phosphorylation, caused no cisternal regrowth. Our results indicate that the phosphorylation of VCIP135 on Threonine-760 and Serine-767 inhibits p97-mediated Golgi membrane fusion at mitosis.

miRNA-135a promotes breast cancer cell migration and invasion by targeting HOXA10

International Nuclear Information System (INIS)

Chen, Yating; Zhang, Hongwei; Ma, Duan; Zhang, Jin; Wang, Huijun; Zhao, Jiayi; Xu, Cheng; Du, Yingying; Luo, Xin; Zheng, Fengyun; Liu, Rui

2012-01-01

miRNAs are a group of small RNA molecules regulating target genes by inducing mRNA degradation or translational repression. Aberrant expression of miRNAs correlates with various cancers. Although miR-135a has been implicated in several other cancers, its role in breast cancer is unknown. HOXA10 however, is associated with multiple cancer types and was recently shown to induce p53 expression in breast cancer cells and reduce their invasive ability. Because HOXA10 is a confirmed miR-135a target in more than one tissue, we examined miR-135a levels in relation to breast cancer phenotypes to determine if miR-135a plays role in this cancer type. Expression levels of miR-135a in tissues and cells were determined by poly (A)-RT PCR. The effect of miR-135a on proliferation was evaluated by CCK8 assay, cell migration and invasion were evaluated by transwell migration and invasion assays, and target protein expression was determined by western blotting. GFP and luciferase reporter plasmids were constructed to confirm the action of miR-135a on downstream target genes including HOXA10. Results are reported as means ± S.D. and differences were tested for significance using 2-sided Student's t-test. Here we report that miR-135a was highly expressed in metastatic breast tumors. We found that the expression of miR-135a was required for the migration and invasion of breast cancer cells, but not their proliferation. HOXA10, which encodes a transcription factor required for embryonic development and is a metastasis suppressor in breast cancer, was shown to be a direct target of miR-135a in breast cancer cells. Our analysis showed that miR-135a suppressed the expression of HOXA10 both at the mRNA and protein level, and its ability to promote cellular migration and invasion was partially reversed by overexpression of HOXA10. In summary, our results indicate that miR-135a is an onco-miRNA that can promote breast cancer cell migration and invasion. HOXA10 is a target gene for mi

27 CFR 26.135 - Containers of distilled spirits to bear closures.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Containers of distilled spirits to bear closures. 26.135 Section 26.135 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO... to bear closures. Containers of 1 gallon (3.785 liters) or less of distilled spirits, upon which all...

Hafty w sztambuchach Biblioteki Uniwersyteckiej w Poznaniu

Directory of Open Access Journals (Sweden)

Karolina Nowaczyk

2011-01-01

Full Text Available W artykule przedstawiono hafty znajdujące się w sztambuchach z XVIII i XIX wieku pochodzących ze zbiorów Biblioteki Uniwersyteckiej w Poznaniu. Omówione zostały zarówno technika wykonania haftów, jak i ich wartość artystyczna, a także znaczenie wskazanych przykładów dla historii hafciarstwa amatorskiego na ziemiach polskich. Artykuł jest jednocześnie próbą zwrócenia uwagi na istniejącą w tamtym okresie sztukę hafciarską o wyłącznie amatorskim charakterze oraz na kopiowanie i powtarzalność wzorów, co pozwala na określenie ich jako typowych dla danej epoki.

24 CFR 583.135 - Administrative costs.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Administrative costs. 583.135... Administrative costs. (a) General. Up to five percent of any grant awarded under this part may be used for the purpose of paying costs of administering the assistance. (b) Administrative costs. Administrative costs...

Flight Testing of the Forward Osmosis Bag for Water Recovery on STS-135

Science.gov (United States)

Roberts, Michael S.; Soler, Monica; Mortenson, Todd; McCoy, LaShelle; Woodward, Spencer; Levine, Howard G.

2011-01-01

The Forward Osmosis Bag (FOB) is a personal water purification device for recovery of potable liquid from almost any non-potable water source. The FOB experiment was flown as a sortie mission on STS-135/ULF7 using flight-certified materials and a design based on the X-Pack(TradeMark) from Hydration Technology Innovations (Albany, OR). The primary objective was to validate the technology for use under microgravity conditions. The FOB utilizes a difference in solute concentration across a selectively permeable membrane to draw water molecules from the non-potable water while rejecting most chemical and all microbial contaminants contained within. Six FOB devices were tested on STS-135 for their ability to produce a potable liquid permeate from a feed solution containing 500 mL potassium chloride (15 g/L) amended with 0.1% methyl blue dye (w:v) tracer against an osmotic gradient created by addition of 60 mL of concentrate containing the osmolytes fructose and glucose, and 0.01% sodium fluorescein (w:v) tracer. Three FOB devices were physically mixed by hand for 2 minutes by a crewmember after loading to augment membrane wetting for comparison with three unmixed FOB devices. Hydraulic flux rate and rejection of salt and dye in microgravity were determined from a 60-mL sample collected by the crew on orbit after 6 hours. Post-flight analysis of samples collected on orbit demonstrated that the Forward Osmosis Bag achieved expected design specifications in microgravity. The hydraulic flux rate of water across the membrane was reduced approximately 50% in microgravity relative to ground controls that generated an average of 50 mL per hour using the same water and osmolyte solutions. The membrane rejected both potassium and chloride at >92% and methyl blue dye at >99.9%. Physical mixing of the FOB during water recovery did not have any significant effect on either flux rate or rejection of solutes from the water solution. The absence of buoyancy-driven convection in

40 CFR 86.135-00 - Dynamometer procedure.

Science.gov (United States)

2010-07-01

... see § 86.135-90. (d) Practice runs over the prescribed driving schedule may be performed at test point...; the rocking of the vehicle changes the tire rolling radius on each roll. This rocking may be minimized...

Phenotype abnormality: 135 [Arabidopsis Phenome Database[Archive

Lifescience Database Archive (English)

Full Text Available 135 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u641i decreased efficiency during process... named seed dormancy process ... decreased efficiency ... seed dormancy process ...

miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERRα.

Directory of Open Access Journals (Sweden)

Violaine Tribollet

Full Text Available MicroRNA-135a (miR-135a down-modulates parameters of cancer progression and its expression is decreased in metastatic breast cancers (as compared to non-metastatic tumors as well as in prostate tumors relative to normal tissue. These expression and activity patterns are opposite to those of the Estrogen-Related Receptor α (ERRα, an orphan member of the nuclear receptor family. Indeed high expression of ERRα correlates with poor prognosis in breast and prostate cancers, and the receptor promotes various traits of cancer aggressiveness including cell invasion. Here we show that miR-135a down-regulates the expression of ERRα through specific sequences of its 3'UTR. As a consequence miR-135a also reduces the expression of downstream targets of ERRα. miR-135a also decreases cell invasive potential in an ERRα-dependent manner. Our results suggest that the decreased expression of miR-135a in metastatic tumors leads to elevated ERRα expression, resulting in increased cell invasion capacities.

Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary 'VoxTox' research programme.

Science.gov (United States)

Burnet, Neil G; Scaife, Jessica E; Romanchikova, Marina; Thomas, Simon J; Bates, Amy M; Wong, Emma; Noble, David J; Shelley, Leila Ea; Bond, Simon J; Forman, Julia R; Hoole, Andrew Cf; Barnett, Gillian C; Brochu, Frederic M; Simmons, Michael Pd; Jena, Raj; Harrison, Karl; Yeap, Ping Lin; Drew, Amelia; Silvester, Emma; Elwood, Patrick; Pullen, Hannah; Sultana, Andrew; Seah, Shannon Yk; Wilson, Megan Z; Russell, Simon G; Benson, Richard J; Rimmer, Yvonne L; Jefferies, Sarah J; Taku, Nicolette; Gurnell, Mark; Powlson, Andrew S; Schönlieb, Carola-Bibiane; Cai, Xiaohao; Sutcliffe, Michael Pf; Parker, Michael A

2017-06-01

The VoxTox research programme has applied expertise from the physical sciences to the problem of radiotherapy toxicity, bringing together expertise from engineering, mathematics, high energy physics (including the Large Hadron Collider), medical physics and radiation oncology. In our initial cohort of 109 men treated with curative radiotherapy for prostate cancer, daily image guidance computed tomography (CT) scans have been used to calculate delivered dose to the rectum, as distinct from planned dose, using an automated approach. Clinical toxicity data have been collected, allowing us to address the hypothesis that delivered dose provides a better predictor of toxicity than planned dose.

Rapid determination of {sup 135}Cs and precise {sup 135}Cs/{sup 137}Cs atomic ratio in environmental samples by single-column chromatography coupled to triple-quadrupole inductively coupled plasma-mass spectrometry

Energy Technology Data Exchange (ETDEWEB)

Yang, Guosheng [Department of Radiation Chemistry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, Aomori 036-8564 (Japan); Division of Nuclear Technology and Applications, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China); Beijing Engineering Research Center of Radiographic Techniques and Equipment, Beijing 100049 (China); Tazoe, Hirofumi [Department of Radiation Chemistry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, Aomori 036-8564 (Japan); Yamada, Masatoshi, E-mail: myamada@hirosaki-u.ac.jp [Department of Radiation Chemistry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, Aomori 036-8564 (Japan)

2016-02-18

For source identification, measurement of {sup 135}Cs/{sup 137}Cs atomic ratio not only provides information apart from the detection of {sup 134}Cs and {sup 137}Cs, but it can also overcome the application limit that measurement of the {sup 134}Cs/{sup 137}Cs ratio has due to the short half-life of {sup 134}Cs (2.06 y). With the recent advancement of ICP-MS, it is necessary to improve the corresponding separation method for rapid and precise {sup 135}Cs/{sup 137}Cs atomic ratio analysis. A novel separation and purification technique was developed for the new generation of triple-quadrupole inductively coupled plasma-mass spectrometry (ICP-MS/MS). The simple chemical separation, incorporating ammonium molybdophosphate selective adsorption of Cs and subsequent single cation-exchange chromatography, removes the majority of isobaric and polyatomic interference elements. Subsequently, the ICP-MS/MS removes residual interference elements and eliminates the peak tailing effect of stable {sup 133}Cs, at m/z 134, 135, and 137. The developed analytical method was successfully applied to measure {sup 135}Cs/{sup 137}Cs atomic ratios and {sup 135}Cs activities in environmental samples (soil and sediment) for radiocesium source identification. - Highlights: • A simple {sup 135}Cs/{sup 137}Cs analytical method was developed. • The separation procedure was based on AMP adsorption and one column chromatography. • {sup 135}Cs/{sup 137}Cs was measured by ICP-MS/MS. • Decontamination factors for Ba, Mo, Sb, and Sn were improved. • {sup 135}Cs/{sup 137}Cs atomic ratios of 0.341–0.351 were found in Japanese soil samples.

Testing Microgravity Flight Hardware Concepts on the NASA KC-135

Science.gov (United States)

Motil, Susan M.; Harrivel, Angela R.; Zimmerli, Gregory A.

2001-01-01

This paper provides an overview of utilizing the NASA KC-135 Reduced Gravity Aircraft for the Foam Optics and Mechanics (FOAM) microgravity flight project. The FOAM science requirements are summarized, and the KC-135 test-rig used to test hardware concepts designed to meet the requirements are described. Preliminary results regarding foam dispensing, foam/surface slip tests, and dynamic light scattering data are discussed in support of the flight hardware development for the FOAM experiment.

Novel Reaction of N,N'-Bisarylmethanediamines with Formaldehyde. Synthesis of Some New 1,3,5-Triaryl-1,3,5-hexahydrotriazines

Directory of Open Access Journals (Sweden)

Abolfazl Olyaei

2006-07-01

Full Text Available The acid-catalyzed cyclocondensation of N,N'-bisaryl (aryl = 2-pyrimidinyl, 2- pyrazinyl and 4-nitrophenyl methanediamines 5a-c with aqueous formaldehyde in refluxing acetonitrile leads to the formation of the corresponding 1,3,5-triaryl-1,3,5-hexa- hydrotriazines 6a-c. The stoichiometric reactions of 2-aminopyrimidine and 2-amino- pyrazine with aqueous formaldehyde in acetonitrile under reflux conditions also afforded 6a and 6b, respectively. Treatment of 2-aminopyrimidine with aqueous formaldehyde in a 3:2 ratio yielded N,N',N"-tris(2-pyrimidinyldimethylenetriamine (7a as a sole product, which upon subsequent reaction with formaldehyde also afforded 6a. The reaction of N,N'-biphenylmethanediamine with formaldehyde was also investigated.

Ekspansja muzeów w Europie Środkowej?

Directory of Open Access Journals (Sweden)

Jagodzińska, Katarzyna

2015-06-01

Full Text Available Przedmiotem artykułu są rozważania na temat specyfiki Europy Środkowej w zakresie kolekcji i muzeów sztuki współczesnej oraz możliwość stworzenia alternatywy regionalnej dla krajów zachodnich. Kontekstem dla tych rozważań jest ekspansjonistyczna polityka współczesnych muzeów, która w związku z licznymi nowymi inwestycjami – w szczególności Luwru, Fundacji Guggenheima, Ermitażu – budzi w świecie muzeologicznym różnorakie dylematy. Autorka omawia światowe "marki muzealne" inwestujące w Europie Środkowej, zastanawia się nad skutkami ekspansji tych "koncernów" dla kultury w regionie, wskazuje też na potencjał regionu, który można wykorzystać bez posiłkowania się nazwiskami światowych kolekcjonerów.

Global spredning af meningokok serogruppe w135

DEFF Research Database (Denmark)

Vestergård, Dorthe; David, Kim P

2008-01-01

Worldwide, meningococcal meningitis and sepsis cause 500,000 cases of illness and 50,000 deaths annually. The increase in global travel activity has resulted in a change in the epidemiology of infectious diseases, and an accumulation of evidence now indicates a connection between pilgrimage and t...

14 CFR Appendix F to Part 135 - Airplane Flight Recorder Specification

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Airplane Flight Recorder Specification F.... F Appendix F to Part 135—Airplane Flight Recorder Specification The recorded values must meet the....125 0.004g 6. Pitch Attitude ±75% ±2° 1 or 0.25 for airplanes operated under § 135.152(j) 0.5° A...

41 CFR 102-80.135 - Who is a qualified fire protection engineer?

Science.gov (United States)

2010-07-01

... protection engineer? 102-80.135 Section 102-80.135 Public Contracts and Property Management Federal Property... qualified fire protection engineer? A qualified fire protection engineer is defined as an individual with a thorough knowledge and understanding of the principles of physics and chemistry governing fire growth...

Determination of the Quantity of I-135 Released from the AGR Experiment Series

International Nuclear Information System (INIS)

Scates, Dawn M.; Walter, John B.; Reber, Edward L.; Sterbentz, James W.; Petti, David A.

2014-01-01

A series of three Advanced Gas Reactor (AGR) experiments have been conducted in the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL). From 2006 through 2014, these experiments supported the development and qualification of the new U.S. tri-structural isotropic (TRISO) particle fuel for Very High Temperature Reactors (VHTR). Each AGR experiment consisted of multiple fueled capsules, each plumbed for independent temperature control using a mix of helium and neon gases. The gas leaving a capsule was routed to individual Fission Product Monitor (FPM) detectors. For intact fuel particles, the TRISO particle coatings provide a substantial barrier to fission product release. However, particles with failed coatings, whether because of a minute percentage of initially defective particles, those which fail during irradiation, or those designed-to-fail (DTF) particles, can release fission products to the flowing gas stream. Because reactive fission product elements like iodine and cesium quickly deposit on cooler capsule components and piping structures as the effluent gas leaves the reactor core, only the noble fission gas isotopes of Kr and Xe tend to reach FPM detectors. The FPM system utilizes High Purity Germanium (HPGe) detectors coupled with a thallium activated sodium iodide NaI(Tl) scintillator. The germanium detector provides individual isotopic information, while the NaI(Tl) scintillator is used as a gross count rate meter. During irradiation, the "1"3"5"mXe concentration reaching the FPM detectors is from both direct fission and by decay of the accumulated "1"3"5I. About ~2.5 hours after irradiation (ten 15.3 minute "1"3"5mXe half-lives) the directly produced "1"3"5"mXe has decayed and only the longer lived "1"3"5I remains as a source. Decay systematics dictate that "1"3"5"mXe will be in secular equilibrium with its "1"3"5I parent, such that it’s production rate very nearly equals the decay rate of the parent, and its concentration in the flowing

Production of W + W - pairs via γ * γ * → W + W - subprocess with photon transverse momenta

Science.gov (United States)

Łuszczak, Marta; Schäfer, Wolfgang; Szczurek, Antoni

2018-05-01

We discuss production of W + W - pairs in proton-proton collisions induced by two-photon fusion including, for a first time, transverse momenta of incoming photons. The unintegrated inelastic fluxes (related to proton dissociation) of photons are calculated based on modern parametrizations of deep inelastic structure functions in a broad range of their arguments ( x and Q 2). In our approach we can get separate contributions of different W helicities states. Several one- and two-dimensional differential distributions are shown and discussed. The present results are compared to the results of previous calculations within collinear factorization approach. Similar results are found except of some observables such as e.g. transverse momentum of the pair of W + and W -. We find large contributions to the cross section from the region of large photon virtualities. We show decomposition of the total cross section as well as invariant mass distribution into the polarisation states of both W bosons. The role of the longitudinal F L structure function is quantified. Its inclusion leads to a 4-5% decrease of the cross section, almost independent of M WW .

Zmienność zasobów termicznych w Polsce w aspekcie obserwowanych zmian klimatu

Directory of Open Access Journals (Sweden)

Agnieszka Sulikowska

2016-06-01

Full Text Available Obserwowany wzrost temperatury powietrza na półkuli północnej, zwłaszcza w Europie, może prowadzić do znacznych zmian w fenologii roślin, a w konsekwencji także w produkcji rolnej. Celem pracy jest ocena zróżnicowania przestrzennego zasobów termicznych na obszarze Polski oraz ich zmienności w okresie 1951–2010 w obliczu zmieniających się warunków termicznych. Analizę przeprowadzono z wykorzystaniem dobowych wartości temperatury powietrza. Zasoby termiczne zdefiniowane zostały za pomocą sum temperatur efektywnych (Growing Degree Days – GDD obliczonych dla wartości progowych temperatury powietrza: 0°C, 5°C i 10°C. Następstwem analizy zróżnicowania przestrzennego zasobów termicznych była ocena ich zmienności wieloletniej oraz tendencji zmian. Badania objęły w szczególności regiony sadownicze odznaczające się największą powierzchnią upraw drzew owocowych oraz wielkością zbiorów jabłek, śliw i wiśni. Uzyskane wyniki potwierdzają zwiększenie zasobów termicznych na obszarze kraju, będące konsekwencją wydłużającego się okresu wegetacyjnego.

Doświadczalna analiza współczynników oporów lokalnych na kolankach w systemach przewodów wielowarstwowych

Directory of Open Access Journals (Sweden)

Natalia Krystyna Gietka

2015-03-01

Full Text Available Zastosowanie tworzyw sztucznych jako materiału do budowy instalacji wymusiło konieczność weryfikacji dostępnych obecnie informacji dotyczących wartości współczynników oporów lokalnych, które stanowią niezbędną wiedzę potrzebną do obliczania wartości strat energii mechanicznej, jakie powstają w trakcie przepływu. Współczynniki te mają duże znaczenie w obliczeniach hydraulicznych wymiarowanej instalacji. Wpływają one na końcowy wynik w istotny sposób, dlatego nieprawidłowe ich przyjęcie może prowadzić do poważnych w skutkach błędów. Niestety wartości podawane przez producentów, normy czy też literaturę są inne w porównaniu z wartościami uzyskiwanymi metodą doświadczalnych badań. W artykule zaprezentowane zostały wyniki badań doświadczalnych, mających na celu wyznaczenie wartości współczynników oporów lokalnych na kolankach 90° trzech określonych średnic, pochodzących od czterech wybranych producentów systemów instalacyjnych. Otrzymane wartości współczynników oporów lokalnych porównano z wartościami, jakie podawane są przez producenta złączek, wyznaczonymi według normy PN-76/M-34034: 1976 oraz dostępnymi w literaturze przedmiotu.

24 CFR 901.135 - Memorandum of Agreement.

Science.gov (United States)

2010-04-01

... DEVELOPMENT PUBLIC HOUSING MANAGEMENT ASSESSMENT PROGRAM § 901.135 Memorandum of Agreement. (a) After..., the training of PHA employees in specific management areas or assistance in the resolution of.../Area Office. (c) The Department encourages the inclusion of the resident leadership in MOA negotiations...

14 CFR 135.329 - Crewmember training requirements.

Science.gov (United States)

2010-01-01

... of the crewmember: (1) Basic indoctrination ground training for newly hired crewmembers including... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Crewmember training requirements. 135.329... REQUIREMENTS: COMMUTER AND ON DEMAND OPERATIONS AND RULES GOVERNING PERSONS ON BOARD SUCH AIRCRAFT Training...

Resonance Raman investigation of the radical cation of 1,3,5-hexatriene

DEFF Research Database (Denmark)

Keszhelyi, T.; Wilbrandt, R.; Cave, R.J.

1994-01-01

The resonance Raman spectrum of the 1,3,5-hexatriene radical cation generated by gamma-irradiation in a Freon glass is reported. The spectrum is excited at 395 nm in resonance with the second absorption band. Identical spectra are obtained from ionized (E)- and (Z)-1,3,5-hexatriene. The presence...

75 FR 38179 - Proposed Collection; Comment Request for Forms W-8BEN, W-8ECI, W-8EXP, and W-8IMY

Science.gov (United States)

2010-07-01

... W-8BEN, W-8ECI, W- 8EXP, and W-8IMY AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice... soliciting comments concerning Form W-8BEN, Certificate of Foreign Status of Beneficial Owner for United States Tax Withholding, Form W-8ECI, Certificate of Foreign Person's Claim for Exemption From Withholding...

41 CFR 102-192.135 - Must we have a mail center manager at our facility?

Science.gov (United States)

2010-07-01

... center manager at our facility? 102-192.135 Section 102-192.135 Public Contracts and Property Management... PROGRAMS 192-MAIL MANAGEMENT Mail Center Manager Requirements § 102-192.135 Must we have a mail center manager at our facility? Yes, every facility that has more than two full time people dedicated to...

A Study of $W^{+}W^{-}\\gamma$ Events at LEP

CERN Document Server

Abbiendi, G; Åkesson, P F; Alexander, G; Allison, J; Amaral, P; Anagnostou, G; Anderson, K J; Arcelli, S; Asai, S; Axen, D A; Azuelos, Georges; Bailey, I; Barberio, E; Barlow, R J; Batley, J Richard; Bechtle, P; Behnke, T; Bell, K W; Bell, P J; Bella, G; Bellerive, A; Benelli, G; Bethke, Siegfried; Biebel, O; Boeriu, O; Bock, P; Boutemeur, M; Braibant, S; Brigliadori, L; Brown, R M; Büsser, K; Burckhart, H J; Campana, S; Carnegie, R K; Caron, B; Carter, A A; Carter, J R; Chang, C Y; Charlton, D G; Csilling, Akos; Cuffiani, M; Dado, S; de Roeck, A; De Wolf, E A; Desch, Klaus; Dienes, B; Donkers, M; Dubbert, J; Duchovni, E; Duckeck, G; Duerdoth, I P; Etzion, E; Fabbri, Franco Luigi; Feld, L; Ferrari, P; Fiedler, F; Fleck, I; Ford, M; Frey, A; Fürtjes, A; Gagnon, P; Gary, J W; Gaycken, G; Geich-Gimbel, C; Giacomelli, G; Giacomelli, P; Giunta, M; Goldberg, J; Gross, E; Grunhaus, Jacob; Gruwé, M; Günther, P O; Sen-Gupta, A; Hajdu, C; Hamann, M; Hanson, G G; Harder, K; Harel, A; Harin-Dirac, M; Hauschild, M; Hawkes, C M; Hawkings, R; Hemingway, Richard J; Hensel, C; Herten, G; Heuer, R D; Hill, J C; Hoffman, K; Horváth, D; Igo-Kemenes, P; Ishii, K; Jeremie, H; Jovanovic, P; Junk, T R; Kanaya, N; Kanzaki, J; Karapetian, G V; Karlen, Dean A; Kawagoe, K; Kawamoto, T; Keeler, Richard K; Kellogg, R G; Kennedy, B W; Kim, D H; Klein, K; Klier, A; Kluth, S; Kobayashi, T; Kobel, M; Komamiya, S; Kormos, L L; Kramer, T; Krieger, P; Von Krogh, J; Krüger, K; Kühl, T; Kupper, M; Lafferty, G D; Landsman, Hagar Yaël; Lanske, D; Layter, J G; Leins, A; Lellouch, D; Letts, J; Levinson, L; Lillich, J; Lloyd, S L; Loebinger, F K; Lü, J; Ludwig, J; MacPherson, A; Mader, W; Marcellini, S; Martin, A J; Masetti, G; Mashimo, T; Mättig, P; McDonald, W J; McKenna, J A; McMahon, T J; McPherson, R A; Meijers, F; Menges, W; Merritt, F S; Mes, H; Michelini, Aldo; Mihara, S; Mikenberg, G; Miller, D J; Moed, S; Mohr, W; Mori, T; Mutter, A; Nagai, K; Nakamura, I; Nanjo, H; Neal, H A; Nisius, R; O'Neale, S W; Oh, A; Okpara, A N; Oreglia, M J; Orito, S; Pahl, C; Pásztor, G; Pater, J R; Patrick, G N; Pilcher, J E; Pinfold, J L; Plane, D E; Poli, B; Polok, J; Pooth, O; Przybycien, M B; Quadt, A; Rabbertz, K; Rembser, C; Renkel, P; Roney, J M; Rosati, S; Rozen, Y; Runge, K; Sachs, K; Saeki, T; Sarkisyan-Grinbaum, E; Schaile, A D; Schaile, O; Scharff-Hansen, P; Schieck, J; Schörner-Sadenius, T; Schröder, M; Schumacher, M; Schwick, C; Scott, W G; Seuster, R; Shears, T G; Shen, B C; Sherwood, P; Siroli, G P; Skuja, A; Smith, A M; Sobie, R J; Söldner-Rembold, S; Spanó, F; Stahl, A; Stephens, K; Strom, D; Ströhmer, R; Tarem, S; Tasevsky, M; Taylor, R J; Teuscher, R; Thomson, M A; Torrence, E; Toya, D; Tran, P; Trigger, I; Trócsányi, Z L; Tsur, E; Turner-Watson, M F; Ueda, I; Ujvári, B; Vollmer, C F; Vannerem, P; Vertesi, R; Verzocchi, M; Voss, H; Vossebeld, Joost Herman; Waller, D; Ward, C P; Ward, D R; Watkins, P M; Watson, A T; Watson, N K; Wells, P S; Wengler, T; Wermes, N; Wetterling, D; Wilson, G W; Wilson, J A; Wolf, G; Wyatt, T R; Yamashita, S; Zer-Zion, D; Zivkovic, L

2004-01-01

A study of W+W- events accomanied by hard photon radiation produced in e+e- collisions at LEP is presented. Events consistent with being two on-shell W bosons and an isolated photon are selected from 681 pb^-1 of data recorded at 180 GeV < sqrt(s) < 209 GeV. For these data , 187 W+W- candidates are selected with photon energies greater than 2.5 GeV. The selected events are used to determine the W+ W- gamma cross section at five values of sqrt(s). The results are consistent with the Standard Model expectation. These data provide constraints on the related O(alpha) systematic uncertainties on the measurement of the W boson mass at LEP. Finally, the data are used to derive 95% C.L. upper limits on possible anomalous contributions to the W+ W- gamma gamma and W+ W- Z0 gamma vertices.

Hole-assisted fiber based fiber fuse terminator supporting 22 W input

Science.gov (United States)

Tsujikawa, Kyozo; Kurokawa, Kenji; Hanzawa, Nobutomo; Nozoe, Saki; Matsui, Takashi; Nakajima, Kazuhide

2018-05-01

We investigated the air hole structure in hole-assisted fiber (HAF) with the aim of terminating fiber fuse propagation. We focused on two structural parameters c/MFD and S1/S2, which are related respectively to the position and area of the air holes, and mapped their appropriate values for terminating fiber fuse propagation. Here, MFD is the mode field diameter, c is the diameter of an inscribed circle linking the air holes, S1 is the total area of the air holes, and S2 is the area of a circumscribed circle linking the air holes. On the basis of these results, we successfully realized a compact fiber fuse terminator consisting of a 1.35 mm-long HAF, which can terminate fiber fuse propagation even with a 22 W input. In addition, we observed fiber fuse termination using a high-speed camera. We additionally confirmed that the HAF-based fiber fuse terminator is effective under various input power conditions. The penetration length of the optical discharge in the HAF was only less than 300 μm when the input power was from 2 to 22 W.

2333-IJBCS-Article-Ulrich Maloueki

African Journals Online (AJOL)

hp

Activité antioxydante par le radical 1,1- diphényl-2-picrylhydrazyle (DPPH). Un composé à activité antioxydante mis en présence du radical libre DPPH. (couleur violet), vire en jaune en donnant un proton au radical. Evaluation qualitative par chromatographie sur couche mince (CCM). La réalisation de la CCM a été.

Shostakovich: Symphony N14, Op. 135 / Edward Greenfield

Index Scriptorium Estoniae

Greenfield, Edward

1994-01-01

Uuest heliplaadist "Shostakovich: Symphony N14, Op. 135; Mussorgsky: Songs and Dances of Death. Ljuba Kazarnovskaya (sop.), Brigitte Fassbaender (mez), Sergei Leiferkus (bar), Gothenburg Symphony Orchestra, Neeme Järvi" DG CD 437 785 - 2GH

Physical properties of W gravities and W strings

International Nuclear Information System (INIS)

Das, S.R.; Dhar, A.; Rama, S.K.

1991-01-01

This paper investigates some basic physical properties of W gravities and W strings, using a free field realization. The authors argue that the configuration space of W gravities have global characteristics in addition to the Euler characteristic. The authors identify one such global quantity to be a monopole charge and show how this charge appears in the exponents. The free energy would then involve a θ parameter. Using a BRST procedure the authors find all the physical states of W 3 and W 4 gravities, and show that physical operators are nonsingular composites of the screening charge operators. (The latter are not physical operators for N ≥ 3.) For W strings we show how the W constraints lead to the emergence of a single (and not many) extra dimension coming from the W-gravity sector. By analyzing the resulting dispersion relations the authors find that both the lower and upper critical dimensions are lowered compared to ordinary two-dimensional gravity. The pure W gravity spectrum reveals an intriguing numerological connection with unitary minimal models coupled to ordinary gravity

Demonstration that Australian Pasteurella multocida isolates from sporadic outbreaks of porcine pneumonia are non-toxigenic (toxA-) and display heterogeneous DNA restriction endonuclease profiles compared with toxigenic isolates from herds with progressive atrophic rhinitis.

Science.gov (United States)

Djordjevic, S P; Eamens, G J; Ha, H; Walker, M J; Chin, J C

1998-08-01

Capsular types A and D of Pasteurella multocida cause economic losses in swine because of their association with progressive atrophic rhinitis (PAR) and enzootic pneumonia. There have been no studies comparing whole-cell DNA profiles of isolates associated with these two porcine respiratory diseases. Twenty-two isolates of P. multocida from diseased pigs in different geographic localities within Australia were characterised genotypically by restriction endonuclease analysis (REA) with the enzyme CfoI. Seven of 12 P. multocida isolates from nasal swabs from pigs in herds where PAR was either present or suspected displayed a capsular type D phenotype. These were shown to possess the toxA gene by polymerase chain reaction (PCR) and Southern hybridisation, and further substantiated by production of cytotoxin in vitro. The CfoI profile of one of these seven isolates, which was from the initial outbreak of PAR in Australia (in Western Australia, WA), was identical with profiles of all six other toxigenic isolates from sporadic episodes in New South Wales (NSW). The evidence suggests that the strain involved in the initial outbreak was responsible for the spread of PAR to the eastern states of Australia. Another 10 isolates, representing both capsular types A and D, were isolated exclusively from porcine lung lesions after sporadic outbreaks of enzootic pneumonia in NSW and WA. CfoI restriction endonuclease profiles of these isolates revealed considerable genomic heterogeneity. Furthermore, none of these possessed the toxA gene. This suggests that P. multocida strains with the toxA gene do not have a competitive survival advantage in the lower respiratory tract or that toxin production does not play a role in the pathology of pneumonic lesions, or both. REA with polyacrylamide gel electrophoresis and silver staining was found to be a practical and discriminatory tool for epidemiological tracing of P. multocida outbreaks associated with PAR or pneumonia in pigs.

14 CFR 135.422 - Aging airplane inspections and records reviews for multiengine airplanes certificated with nine...

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Aging airplane inspections and records reviews for multiengine airplanes certificated with nine or fewer passenger seats. 135.422 Section 135.422... Maintenance, and Alterations § 135.422 Aging airplane inspections and records reviews for multiengine...

44 CFR 19.135 - Designation of responsible employee and adoption of grievance procedures.

Science.gov (United States)

2010-10-01

... BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Introduction... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Designation of responsible employee and adoption of grievance procedures. 19.135 Section 19.135 Emergency Management and Assistance...

Spuścizny konserwatorów zbiorów, kierowników i dyrektorów Biblioteki Poznańskiego Towarzystwa Przyjaciół Nauk

Directory of Open Access Journals (Sweden)

Michał Boksa

2011-01-01

Full Text Available Artykuł prezentuje sylwetki konserwatorów zbiorów, kierowników i dyrektorów Biblioteki Poznańskiego Towarzystwa Przyjaciół Nauk (PTPN oraz to, co po nich pozostało w postaci archiwaliów. Od momentu powstania Biblioteka PTPN gromadziła rękopisy lub całe spuścizny wybitnych osób, w tym kierujących tą placówką. Również inne biblioteki i archiwa zakładowe instytucji, z którymi byli oni związani, włączały do swych zbiorów ich materiały archiwalne. Spuścizny Ludwiki Dobrzyńskiej-Rybickiej i Ryszarda Marciniaka znajdują się zarówno w Bibliotece PTPN, jak i w Polskiej Akademii Nauk Archiwum w Warszawie Oddział w Poznaniu. Znaczna część materiałów archiwalnych Bolesława Erzepkiego trafiła natomiast do Działu Zbiorów Specjalnych Biblioteki Raczyńskich w Poznaniu. Szczątkowe materiały archiwalne można też znaleźć w Archiwum Uniwersytetu im. Adama Mickiewicza w Poznaniu (Ludwika Dobrzyńska-Rybicka oraz w Archiwum Biblioteki Uniwersyteckiej w Poznaniu (Ludwika Dobrzyńska-Rybicka, Jan Baumgart, Aniela Koehlerówna.

FutureTox II: in vitro data and in silico models for predictive toxicology.

Science.gov (United States)

Knudsen, Thomas B; Keller, Douglas A; Sander, Miriam; Carney, Edward W; Doerrer, Nancy G; Eaton, David L; Fitzpatrick, Suzanne Compton; Hastings, Kenneth L; Mendrick, Donna L; Tice, Raymond R; Watkins, Paul B; Whelan, Maurice

2015-02-01

FutureTox II, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in January, 2014. The meeting goals were to review and discuss the state of the science in toxicology in the context of implementing the NRC 21st century vision of predicting in vivo responses from in vitro and in silico data, and to define the goals for the future. Presentations and discussions were held on priority concerns such as predicting and modeling of metabolism, cell growth and differentiation, effects on sensitive subpopulations, and integrating data into risk assessment. Emerging trends in technologies such as stem cell-derived human cells, 3D organotypic culture models, mathematical modeling of cellular processes and morphogenesis, adverse outcome pathway development, and high-content imaging of in vivo systems were discussed. Although advances in moving towards an in vitro/in silico based risk assessment paradigm were apparent, knowledge gaps in these areas and limitations of technologies were identified. Specific recommendations were made for future directions and research needs in the areas of hepatotoxicity, cancer prediction, developmental toxicity, and regulatory toxicology. © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

27 CFR 24.135 - Wine premises alternation.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Wine premises alternation..., DEPARTMENT OF THE TREASURY LIQUORS WINE Establishment and Operations Alternation § 24.135 Wine premises alternation. (a) General. The proprietor of a bonded winery or bonded wine cellar may alternate all or a...

Determination of {sup 135}Cs and {sup 137}Cs in environmental samples: A review

Energy Technology Data Exchange (ETDEWEB)

Russell, B.C., E-mail: ben.russell@npl.co.uk [GAU-Radioanalytical, Ocean and Earth Science, University of Southampton, National Oceanography Centre, Southampton, SO14 3ZH (United Kingdom); National Physical Laboratory, Hampton Road, Teddington, Middlesex, TW11 0LW (United Kingdom); Croudace, Ian W.; Warwick, Phil E. [GAU-Radioanalytical, Ocean and Earth Science, University of Southampton, National Oceanography Centre, Southampton, SO14 3ZH (United Kingdom)

2015-08-26

Radionuclides of caesium are environmentally important since they are formed as significant high yield fission products ({sup 135}Cs and {sup 137}Cs) and activation products ({sup 134}Cs and {sup 136}Cs) during nuclear fission. They originate from a range of nuclear activities such as weapons testing, nuclear reprocessing and nuclear fuel cycle discharges and nuclear accidents. Whilst {sup 137}Cs, {sup 134}Cs and {sup 136}Cs are routinely measurable at high sensitivity by gamma spectrometry, routine detection of long-lived {sup 135}Cs by radiometric methods is challenging. This measurement is, however, important given its significance in long-term nuclear waste storage and disposal. Furthermore, the {sup 135}Cs/{sup 137}Cs ratio varies with reactor, weapon and fuel type, and accurate measurement of this ratio can therefore be used as a forensic tool in identifying the source(s) of nuclear contamination. The shorter-lived activation products {sup 134}Cs and {sup 136}Cs have a limited application but provide useful early information on fuel irradiation history and have importance in health physics. Detection of {sup 135}Cs (and {sup 137}Cs) is achievable by mass spectrometric techniques; most commonly inductively coupled plasma mass spectrometry (ICP-MS), as well as thermal ionisation (TIMS), accelerator (AMS) and resonance ionisation (RIMS) techniques. The critical issues affecting the accuracy and detection limits achievable by this technique are effective removal of barium to eliminate isobaric interferences arising from {sup 135}Ba and {sup 137}Ba, and elimination of peak tailing of stable {sup 133}Cs on {sup 135}Cs. Isobaric interferences can be removed by chemical separation, most commonly ion exchange chromatography, and/or instrumental separation using an ICP-MS equipped with a reaction cell. The removal of the peak tailing interference is dependent on the instrument used for final measurement. This review summarizes and compares the analytical procedures

Aspekt formalnoprawny stosowania systemów ustalania lokalizacji w czasie rzeczywistym do eliminacji marnotrawstwa w procesie budowlanym

Directory of Open Access Journals (Sweden)

Piotr Nowotarski

2017-06-01

Full Text Available W artykule przedstawiono ideę systemów typu RTLS pod kątem wykorzystania ich w celu eliminacji marnotrawstwa w procesie budowlanym. Opisywane systemy z punktu widzenia strumienia wartości są pomocne w wykrywaniu czynności niedodających wartości. Autorzy przedstawili temat w aspekcie formalno-prawnym związanym z monitorowaniem i śledzeniem pracowników podczas pracy. Zwrócono uwagę na niezbędne dokumenty, pozwolenia, zgłoszenia i zgody pracowników, które zgodnie z obowiązującym w Polsce prawem należy posiadać, aby móc wykorzystywać tego typu systemy do zbierania i przetwarzania danych o lokalizacji pracowników w trakcie wykonywania prac.

14 CFR 135.41 - Carriage of narcotic drugs, marihuana, and depressant or stimulant drugs or substances.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Carriage of narcotic drugs, marihuana, and depressant or stimulant drugs or substances. 135.41 Section 135.41 Aeronautics and Space FEDERAL AVIATION... PERSONS ON BOARD SUCH AIRCRAFT General § 135.41 Carriage of narcotic drugs, marihuana, and depressant or...

33 CFR 135.223 - Certificates, denial or revocation.

Science.gov (United States)

2010-07-01

... SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND Financial Responsibility for Offshore Facilities § 135.223 Certificates, denial or revocation... false statement to the Fund Administrator in connection with establishing or maintaining evidence of...

Bose-Einstein correlations in W+ W- events at LEP2

CERN Document Server

van Dalen, Jorn A

2000-01-01

Analyses of Bose-Einstein Correlations in w+w- events at LEP2 by the four LEP collaborations are presented. In particular, Bose-Einstein correlations in w+w- overlap are investigated and the possible existence of these correlations between particles coming from different W's, which may influence the W mass measurements in the fully-hadronic channel e+e- --+ w+w- --+ qiihq3ij<. No evidence for such an inter-W Bose-Einstein correlation is found by L3 and ALEPH. Possible indication of these correlations by DELPHI is mentioned.

Akcentuacja zapożyczonych leksemów czasownikowych w gwarze staroobrzędowców mieszkających w regionie suwalsko-augustowskim

Directory of Open Access Journals (Sweden)

Dorota Angelika Paśko-Koneczniak

2015-12-01

Full Text Available Stress patterns in loan verb lexemes in the dialect used by the Old Believers living in the Suwałki-Augustów region The aim of the article is to present the stress pattern phenomenon in loan verb lexemes which function in the Russian dialect of the Old Believers from the Suwałki-Augustów Region. In the last decades, the insular dialect, separated from the general Russian language, has been influenced by the Polish language. Such influence is visible, in particular, in the vocabulary, in the form of loan translations and idiomatic expressions. Stress patterns, along with the root vocabulary and the morphological system, still remains one of the indicators of the Russian essence of the dialect. The native vocabulary of the Old Believers’ dialect maintains Russian accentuation patterns. A similar situation is observed in the case of stress patterns in lexemes borrowed from Polish, which undergo a stress accentuation adaptation; that is, they feature a shift in the place of the stress in relation to the source language. In loan verb morphemes, one can notice the pattern of stress which is not fixed and depends upon the morphological form or, sometimes, the paroxitonic stress, which results from the influence of the Polish language.   Akcentuacja zapożyczonych leksemów czasownikowych w gwarze staroobrzędowców mieszkających w regionie suwalsko-augustowskim Celem artykułu jest zaprezentowanie zjawiska akcentuacji w zapożyczonych leksemach czasownikowych, funkcjonujących w rosyjskiej gwarze staroobrzędowców z regionu suwalsko-augustowskiego. W ciągu ostatnich kilkudziesięciu lat badana gwara wyspowa, odseparowana od rosyjskiego języka ogólnego, podlega znacznemu wpływowi języka polskiego. Wpływ polszczyzny widoczny jest szczególnie w zasobie leksykalnym w postaci zapożyczeń, kalk i w idiomatyce. Akcentuacja obok rdzennego zasobu leksykalnego i systemu morfologicznego nadal pozostaje jednym z wyznaczników rosyjskości gwary

Evaluation of w values for carbon beams in air, using a graphite calorimeter.

Science.gov (United States)

Sakama, Makoto; Kanai, Tatsuaki; Fukumura, Akifumi; Abe, Kyoko

2009-03-07

Despite recent progress in carbon therapy, accurate values for physical data such as the w value in air or stopping power ratios for ionization chamber dosimetry have not been obtained. The absorbed dose to graphite obtained with the graphite calorimeter was compared with that obtained using the ionization chambers following the IAEA protocol in order to evaluate the w values in air for mono-energetic carbon beams of 135, 290, 400 and 430 MeV/n. Two cylindrical chambers (PTW type 30001 and PTW type 30011, Farmer) and two plane-parallel chambers (PTW type 23343, Markus and PTW type 34001, Roos) calibrated by the absorbed dose to graphite and exposure to the (60)Co photon beam were used. The comparisons to our calorimeter measurements revealed that, using the ionization chambers, the absorbed dose to graphite comes out low by 2-6% in this experimental energy range and with these chamber types and calibration methods. In the therapeutic energy range, the w values in air for carbon beams indicated a slight energy dependence; we, however, assumed these values to be constant for practical use because of the large uncertainty and unknown perturbation factors of the ionization chambers. The w values in air of the carbon beams were evaluated to be 35.72 J C(-1) +/- 1.5% in the energy range used in this study. This value is 3.5% larger than that recommended by the IAEA TRS 398 for heavy-ion beams. Using this evaluated result, the absorbed dose to water in the carbon beams would be increased by the same amount.

Samostanowienie narodów w prawie międzynarodowym

OpenAIRE

Żbikowski, Wawrzyniec

2015-01-01

W artykule omówiono zasadę samostanowienia narodów funkcjonującą w prawie międzynarodowym od momentu uchwalenia Karty Narodów Zjednoczonych. Po przedstawieniu tła historycznego ukazano źródła funkcjonowania tej zasady oraz problematykę związaną z jej podmiotowym i przedmiotowym zakresem. Dokonano tego na podstawie analizy źródeł, praktyki oraz poglądów doktryny. Podjęto też kwestię realizacji prawa do samostanowienia jako jednego z możliwych kryteriów państwowości. W końcowej części szeroko o...

SPECYFIKA REALIZACJI LINIOWYCH INWESTYCJI W PASIE DROGOWYM W AGLOMERACJI MIEJSKIEJ Z UWZGLĘDNIENIEM OBSZARÓW ZABYTKOWYCH

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Andrzej MARECKI

Full Text Available Treścią referatu jest problematyka budowlanego procesu inwestycyjnego w pasie drogowym na terenie miast. W aglomeracjach miejskich realizacja zadań związanych z budową, przebudową lub modernizacją ciągów drogowych lub sieci infrastruktury liniowej związana jest z pokonaniem szczególnych utrudnień. Wynika to nie tylko ze specyfiki technologicznej ale również z szeroko pojętej interakcji społecznych. Inwestorzy realizujący zadania w miastach muszą szukać nie tylko innowacyjnych rozwiązań technicznych ale również muszą spełniać, często - „wygórowane” oczekiwania społeczne. W referacie omówione zostaną typowe zagrożenia procesu inwestycyjnego na etapach koncepcji, projektowania, realizacji i eksploatacji - ze szczególnym uwzględnieniem aspektów dotyczących realizacji liniowych robót budowlanych na obszarach objętych warunkami ochrony, wynikającymi z zapisów ustawy o ochronie zabytków[1]. Należy podkreślić, że ochrona ta zgodnie z Art. 4 przedmiotowej Ustawy polega, na podejmowaniu przez organy administracji publicznej działań mających między innymi na celu: zapewnienie warunków prawnych, organizacyjnych i finansowych, umożliwiających trwałe zachowanie zabytków oraz ich zagospodarowanie i utrzymanie. Przekłada się to na obligatoryjny warunek prowadzenia prac konserwatorskich, restauratorskich i oczywiście robót budowlanych za pozwoleniem właściwego konserwatora zabytków i pod jego nadzorem. Realizacja liniowych zadań inwestycyjnych z natury rzeczy odbywa się nie tylko w obszarze wpływu zabytków nieruchomych ale także w bezpośrednim kontakcie z zabytkami archeologicznymi tj. – zabytkami nieruchomymi, będącymi powierzchniową, podziemną lub podwodną pozostałością egzystencji i działalności człowieka, złożoną z nawarstwień kulturowych i znajdujących się w nich wytworów bądź ich śladów. Warunkiem pogodzenia interesów stron tego skomplikowanego procesu

ZASTOSOWANIE METOD GIS W ANALIZIE STRUKTURY PRZESTRZENNEJ OBSZARÓW WIEJSKICH GMINY SŁAWNO W POWIECIE OPOCZYŃSKIM

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Przemysław LEŃ

Full Text Available Celem pracy jest przedstawienie możliwości wykorzystania narzędzi GIS w analizie struktury przestrzennej obszarów wiejskich. Badania przeprowadzono w 34 wsiach gminy Sławno położonej w powiecie opoczyńskim, województwo łódzkie. W pracy przeprowadzono analizy dotyczące struktury władania gruntami, analizy użytkowania gruntami, jak również analizę rozdrobnienia gruntów gospodarstw indywidualnych. Otrzymane wyniki pozwolą określić stan struktury przestrzennej obszarów wiejskich Polski centralnej.

Prezentacja innych dochodów całkowitych w sprawozdaniach finansowych wybranych spółek publicznych w Polsce w latach 2009–2011

Directory of Open Access Journals (Sweden)

Bogusława Bek-Gaik

2013-04-01

Full Text Available Inne całkowite dochody to nowa kategoria ekonomiczna, dopiero testowana w praktyce gospodarczej. Oczywi-sty wydaje się fakt zapotrzebowania na badanie aspektów praktycznych dotyczących prezentacji innych całkowitych dochodów w sprawozdaniu z dochodów całkowitych. Zasadniczym celem niniejszego artykułu jest zbadanie, jaką formę prezentacji innych całkowitych dochodów w sprawozdaniu z całkowitych dochodów wybrały polskie spółki giełdowe, jaka jest istotność wyniku całkowitego oraz średnia liczba pozycji ujawnia-nych w ramach innych zysków całkowitych przez badane spółki publiczne (struktura innych zysków całko-witych. Metodą badawczą zastosowaną w artykule były studia literaturowe, analiza regulacji dotyczących sprawozdania z całkowitych dochodów (głównie MSR 1 oraz analiza sprawozdań finansowych sporządzo-nych zgodnie z Międzynarodowymi Standardami Sprawozdawczości Finansowej wybranych polskich spółek publicznych w latach 2009–2011. Wyniki badań wskazują, że w praktyce mamy do czynienia z indywidual-nym podejściem do zasad prezentacji informacji o innych całkowitych dochodach. Niewątpliwą wadą takie-go sposobu prezentacji jest brak możliwości porównywania poszczególnych kategorii sprawozdań między spółkami; analiza porównawcza jest pracochłonna i wymaga poszukiwania danych w wielu notach.

Rozłam w operaizmie w świetle dynamiki włoskiego ruchu robotniczego w „czerwonym dziesięcioleciu” (1969–1980

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Zbigniew Marcin Kowalewski

2015-12-01

Full Text Available Operaizm powstał w 1960–1961 roku z inicjatywy Raniero Panzieriego jako nurt radykalnej odnowy teoretycznej marksizmu w walce z obiektywizmem i historyzmem oraz równie radykalnej odnowy strategicznej ruchu robotniczego w walce z dominującym w nim reformizmem. Miał mieć za podstawę materialistyczną lekturę Kapitału „z robotniczego punktu widzenia”. Wkrótce okazało się, że jest głęboko podzielony teoretycznie i politycznie. W 1963 roku w środowisku operaistycznym nastąpił rozłam. Większość skupiona wokół Maria Trontiego oddzieliła się, dokonując antymaterialistycznej rewizji marksizmu i stworzyła metafizykę autonomii robotniczej. Ogromna fala walk robotniczych w latach 1969–1980 przyniosła wyraźne rozstrzygnięcia w fundamentalnych kwestiach spornych, które podzieliły operaistów.

EU Framework 6 Project: Predictive Toxicology (PredTox)-overview and outcome

International Nuclear Information System (INIS)

Suter, Laura; Schroeder, Susanne; Meyer, Kirstin; Gautier, Jean-Charles; Amberg, Alexander; Wendt, Maria; Gmuender, Hans; Mally, Angela; Boitier, Eric; Ellinger-Ziegelbauer, Heidrun; Matheis, Katja; Pfannkuch, Friedlieb

2011-01-01

In this publication, we report the outcome of the integrated EU Framework 6 Project: Predictive Toxicology (PredTox), including methodological aspects and overall conclusions. Specific details including data analysis and interpretation are reported in separate articles in this issue. The project, partly funded by the EU, was carried out by a consortium of 15 pharmaceutical companies, 2 SMEs, and 3 universities. The effects of 16 test compounds were characterized using conventional toxicological parameters and 'omics' technologies. The three major observed toxicities, liver hypertrophy, bile duct necrosis and/or cholestasis, and kidney proximal tubular damage were analyzed in detail. The combined approach of 'omics' and conventional toxicology proved a useful tool for mechanistic investigations and the identification of putative biomarkers. In our hands and in combination with histopathological assessment, target organ transcriptomics was the most prolific approach for the generation of mechanistic hypotheses. Proteomics approaches were relatively time-consuming and required careful standardization. NMR-based metabolomics detected metabolite changes accompanying histopathological findings, providing limited additional mechanistic information. Conversely, targeted metabolite profiling with LC/GC-MS was very useful for the investigation of bile duct necrosis/cholestasis. In general, both proteomics and metabolomics were supportive of other findings. Thus, the outcome of this program indicates that 'omics' technologies can help toxicologists to make better informed decisions during exploratory toxicological studies. The data support that hypothesis on mode of action and discovery of putative biomarkers are tangible outcomes of integrated 'omics' analysis. Qualification of biomarkers remains challenging, in particular in terms of identification, mechanistic anchoring, appropriate specificity, and sensitivity.

Czynniki prognostyczne progresji radiologicznej w reumatoidalnym zapaleniu stawów

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Piotr Wiland

2010-08-01

Full Text Available Możliwość przewidywania odległych konsekwencji reumatoidalnegozapalenia stawów ma zasadnicze znaczenie dla podejmowaniawłaściwych decyzji terapeutycznych u danego chorego. Markeryprognostyczne są pomocne w identyfikacji chorych o dużym ryzykuszybkiej progresji radiologicznej. Utwierdzają one lekarzaw decyzji o rozpoczęciu intensywnego leczenia u chorych z możliwąznaczną destrukcją stawów w ciągu następnych kilku lat.W artykule zaprezentowano pilotażowy model ryzyka dla przewidywaniaszybkiej progresji radiologicznej. W celu stworzenia tegomodelu posłużono się danymi, w tym wynikami badań radiologicznychpochodzącymi z badania ASPIRE, w którym porównywanomonoterapię metotreksatem z leczeniem skojarzonym metotreksatemi infliksymabem. W tym modelu wybrano wyjściowe parametry,które są łatwe do uzyskania w rutynowej praktyce klinicznej,takie jak: stężenie białka C-reaktywnego, wartość odczynuopadania krwinek czerwonych, liczbę obrzękniętych stawów orazmiano czynnika reumatoidalnego. Ten macierzowy model ryzykamoże być przydatny w ocenie ryzyka postępującego uszkodzeniastawów, szczególnie u chorych z wczesnym zapaleniem stawów.

Factor VII-Induced MicroRNA-135a Inhibits Autophagy and Is Associated with Poor Prognosis in Hepatocellular Carcinoma

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Kuang-Tzu Huang

2017-12-01

Here, we identified miR-135a as a highly upregulated miRNA in HCC in response to TF/FVII/PAR2 activation. Analyzing 103 HCC patient specimens, we confirmed that miR-135a was frequently elevated in HCC tissues with higher FVII expression compared to adjacent non-cancerous counterparts. Increased miR-135a levels in HCC were also associated with tumor staging, recurrence, microvascular invasion, and decreased disease-free survival. We subsequently identified Atg14, a key component that regulates the formation of autophagosome as a direct target of miR-135a. Ectopic expression of miR-135a suppressed Atg14 levels and inhibited the autophagic processes. Our results indicate strong positive correlations between miR-135a levels and malignant behaviors in HCC patients and also suggest novel functions of miR-135a in regulation of autophagy, which could be useful as a potential target for prognostic and therapeutic uses.

BRT-1 code for IBM 370/135

International Nuclear Information System (INIS)

Preda, I.

1976-01-01

BRT-1 is a transport code to obtain the thermal neutrons spectrum, point dependent, in one reactor cell. The code BRT-1 described in this paper, is the code BRT-1, written in FORTRAN IV language for the computer UNIVAC 1108 with CSCX operating system, converted for the computer IBM 370/135 disk operating system. (author)

Polityka rachunkowości spółek notowanych na GPW w Warszawie w zakresie ujmowania przychodów z kontraktów deweloperskich

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Renata Dyląg

2010-04-01

Full Text Available Głównym przedmiotem działalności jednostek z branży deweloperskiej jest rea-lizacja kontraktów deweloperskich, polegających na budowie (bezpośrednio lub poprzez podwykonawców a następnie sprzedaży powierzchni w budynkach handlowych, rozrywkowych, biurowych, hotelowych i mieszkalnych. Brak precyzyjnych rozwią-zań dotyczących ujmowania przychodów z tych kontraktów powodował, że niektóre jednostki ujmowały przychody w momencie przekazania nieruchomości nabywcy (zgodnie z MSR 18 „Przychody”, natomiast inne ujmowały przychody w trakcie trwania okresu budowy tej nieruchomości (zgodnie z MSR 11 „Umowy o budowę”. Celem artykułu jest ocena – przyjmowanych przez spółki deweloperskie noto-wane na warszawskiej Giełdzie Papierów Wartościowych – rozwiązań dotyczących ujmowania przychodów i wyników z kontraktów deweloperskich oraz zaprezento-wanie wpływu interpretacji KIMSF 15 „Umowy dotyczące budowy nieruchomości” na sprawozdawczość tych spółek.

Thermodynamic study of 1,2,3-triphenylbenzene and 1,3,5-triphenylbenzene

International Nuclear Information System (INIS)

Ribeiro da Silva, Manuel A.V.; Santos, Luis M.N.B.F.; Lima, Luis M. Spencer S.

2010-01-01

The energetic study of 1,2,3-triphenylbenzene (1,2,3-TPhB) and 1,3,5-triphenylbenzene (1,3,5-TPhB) isomers was carried out by making use of the mini-bomb combustion calorimetry and Knudsen mass-loss effusion techniques. The mini-bomb combustion calorimetry technique was used to derive the standard (p o = 0.1 MPa) molar enthalpies of formation in the crystalline state from the measured standard molar energies of combustion for both isomers. The Knudsen mass-loss effusion technique was used to measure the dependence with the temperature of the vapour pressure of crystalline 1,2,3-TPhB, which allowed the derivation of the standard molar enthalpy of sublimation, by application of the Clausius-Clapeyron equation. The sublimation study of 1,3,5-TPhB had been performed previously. From the combination of data obtained by both techniques, the standard molar enthalpies of formation in the gaseous state, for both isomers, at T = 298.15 K, were calculated. The results indicate a higher stability of the 1,3,5-TPhB isomer relative to 1,2,3-TPhB, similarly to the terphenyls. Nevertheless, the 1,2,3-TPhB isomer is not as energetically destabilized as one might expect, supporting the existence of a π-π displacive stacking interaction between both pairs of outer phenyl rings. The volatility difference between the two isomers is ruled by the enthalpy of sublimation. The volatility of the 1,2,3-TPhB is two orders of magnitude higher than the 1,3,5-TPhB isomer, at T = 298.15 K.

$W^+ W^-$ + Jet: Compact Analytic Results

Energy Technology Data Exchange (ETDEWEB)

Campbell, John [Fermilab; Miller, David [Glasgow U.; Robens, Tania [Dresden, Tech. U.

2016-01-14

In the second run of the LHC, which started in April 2015, an accurate understanding of Standard Model processes is more crucial than ever. Processes including electroweak gauge bosons serve as standard candles for SM measurements, and equally constitute important background for BSM searches. We here present the NLO QCD virtual contributions to W+W- + jet in an analytic format obtained through unitarity methods and show results for the full process using an implementation into the Monte Carlo event generator MCFM. Phenomenologically, we investigate total as well as differential cross sections for the LHC with 14 TeV center-of-mass energy, as well as a future 100 TeV proton-proton machine. In the format presented here, the one-loop virtual contributions also serve as important ingredients in the calculation of W+W- pair production at NNLO.

12 CFR 19.135 - Applications for stay or review of disciplinary actions imposed by registered clearing agencies.

Science.gov (United States)

2010-01-01

... Involving the Federal Securities Laws § 19.135 Applications for stay or review of disciplinary actions... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Applications for stay or review of disciplinary actions imposed by registered clearing agencies. 19.135 Section 19.135 Banks and Banking COMPTROLLER OF...

Tests to determine the release of short-lived fission products from UO2 fuel operating at linear powers of 45 and 60 kW/m

International Nuclear Information System (INIS)

Hastings, I.J.; Hunt, C.E.L.; Lipsett, J.J.; MacDonald, R.D.

1985-09-01

Experiments have been carried out using a 'sweep gas' technique to determine the behaviour of short-lived fission products within operating, intact UO 2 fuel elements. The Zircaloy-4-clad elements were 600 mm long and contained fuel of density 10.65 - 10.71 Mg/m 3 . A He-2% H 2 carrier gas swept gaseous or volatile fission products out of the operating fuel element past a gamma spectrometer for measurement. We outline our loop model and give full details of calculational procedures. In tests at linear powers of 45 (FIO-122) and 60 kW/m (FIO-124) to a maximum burnup of 80 MW.h/kg U, the species measured directly at the spectrometer during normal operation were generally the short-lived xenons and kryptons. Iodines were not observed during normal operation. The behaviour of I-133 and I-135 was deduced from the decay of Xe-133 and Xe-135 during reactor shutdowns. Plots of R/B (released/born) against λ (decay constant) or effective λ for all isotopes observed at 45 and 60 kW/m show that a line of slope -0.5, corresponding with diffusion kinetics, is a good fit to the measured xenon and krypton data. The inferred release of iodine fits the same line. From this we can extrapolate to an R/B for I-131 of about 5 x 10 -4 at 45 kW/m, and 3 x 10 -3 at 60 kW/m. Both tests were terminated by defects. Under defect conditions, R/B dependence on λ was about 0.6. I-131 release under defect conditions was 5 Ci and 60 mCi for FIO-122 and FI0-124, respectively. 22 refs

14 CFR 135.247 - Pilot qualifications: Recent experience.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Pilot qualifications: Recent experience... Flight Crewmember Requirements § 135.247 Pilot qualifications: Recent experience. (a) No certificate holder may use any person, nor may any person serve, as pilot in command of an aircraft carrying...

CP violating observables in e$^{-}$e$^{+}$ --> W$^{-}$W$^{+}$

CERN Document Server

Chang, D; Phillips, I

1993-01-01

We consider various integrated lepton charge-energy asymmetries and azimuthal asymmetries as tests of CP violation in the process $e^-e^+ \\to W^-W^+$. These asymmetries are sensitive to different linear combinations of the CP violating form factors in the three gauge boson $W^-W^+$ production vertex, and can distinguish dispersive and absorptive parts of the form factors. It makes use of purely hadronic and purely leptonic modes of $W$'s decays as well as the mixed modes. The techniques of using the kinematics of jets or missing momentum to construct CP--odd observables are also employed. These CP violating observables are illustrated in the generalized Left-Right Model and the Charged Higgs Model.

Antitumor effect of a new nano-vector with miRNA-135a on malignant glioma

Directory of Open Access Journals (Sweden)

Liang C

2017-12-01

Full Text Available Chaofeng Liang,1,* Weitong Sun,2,* Haiyong He,1,* Baoyu Zhang,1 Cong Ling,1 Bocheng Wang,1 Tengchao Huang,1 Bo Hou,1 Ying Guo1 1Department of Neurosurgery, 3rd Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangdong, China; 2The Pharmaceutical College of Jiamusi University, Jiamusi University, Jiamusi, China *These authors contributed equally to this work Introduction: MiR-135a is found to selectively induce apoptosis in glioma cell but not in normal neurons and glial cells. However, low transfection efficacy limits its application in vivo as other miRNAs. We prepared a new kind of nano-vector based on polyethylene glycol methyl ether (mPEG and hyper-branched polyethylenimine (hy-PEI in order to improve the miRNA delivery system into the glioma cells. Methods: The mPEG-g-PEI/miR-135a was constructed and detected by 1H NMR and FTIR analyses. Transmission electron microscope was utilized for its characteristics. Stability and release efficiency was assessed by electrophoresis. Biocompatibility was observed and analyzed through co-culture with astrocytes and malignant glioma cells (C6. Transfection rate was monitored by laser confocal microscopy and flow cytometry. The antitumor effect of mPEG-g-PEI/miR-135a to C6 was confirmed in vivo by MR scanning, pathology and survival curve. RT-PCR was used to assay transfection efficiency of mPEG-g-PEI/miR-135a in vitro and in vivo. And Western blotting was used to assess the expressions of the targeted proteins of miR-135a.Results: In this experiment, we found the optimal N/P ratio of mPEG-g-PEI/miR-135a was about 6 judged by Zeta potential, particle size and encapsulation ability. The stability of mPEG-g-PEI/miR-135a in serum and the release efficiency in acid(pH=5.0 of mPEG-g-PEI/miR-135a were simulated the environment in vivo and in tumor. The mPEG-g-PEI nano-vector was co-cultured with malignant glioma cell C6 and normal astrocytes in vitro and showed good biocompatibility

Postawy konsumentów wobec reklam kredytów hipotecznych

OpenAIRE

Kmita, Emilia

2011-01-01

Najważniejszym aspektem poznawczym niniejszej pracy była analiza postaw konsumentów wobec reklam, ze szczególnym uwzględnieniem tych prezentujących kredyty hipoteczne. Weryfikacji postawionych przez mnie hipotez dokonałam poprzez badanie ankietowe przeprowadzone wśród klientów banku Pekao S.A. w Nowym Sączu. Wyniki badań wskazują, iż konsumenci zazwyczaj nie darzą reklam zbyt dużą sympatią czy zaufaniem. W przypadku podejmowania ważnych decyzji życiowych jakimi jest zakup własnego domu oraz w...

W mass and W asymmetry at CDF

International Nuclear Information System (INIS)

Leone, S.

1991-05-01

The lepton charge asymmetry from W decaying into a lepton and a neutrino is discussed (preliminary result). This measurement gives information on parton distribution functions at low x values. The derivation of the recently published W mass value of 79.91 ± 0.39 GeV/c 2 is also presented. M W is used to set an upper limit on the top quark mass. 13 refs., 4 figs., 1 tab

Search for a Standard Model Higgs boson decaying to b quarks and produced in association with Z/W bosons with the CMS detector

Directory of Open Access Journals (Sweden)

Gruttola Michele De

2012-06-01

Full Text Available A search for the standard model Higgs boson is performed in a data sample corresponding to an integrated luminosity of 1.1 fb−1, recorded by the CMS detector in proton-proton collisions at the LHC with a 7 TeV center-of-mass energy. The following modes are studied: W(μνH, W(eνH, Z(μμH, Z(eeH and Z(ννH, with the Higgs decaying to bb pairs. 95% C.L. upper limits on the VH production cross section are derived for a Higgs mass between 110 and 135 GeV. The expected (observed upper limit at 115 GeV is found to be 5.7 (8.3 times the standard model expectation.

A study of $W^{+}W^{-}\\gamma$ events at LEP

CERN Document Server

Abbiendi, G; Åkesson, P F; Alexander, G; Allison, J; Amaral, P; Anagnostou, G; Anderson, K J; Arcelli, S; Asai, A; Axen, D; Azuelos, Georges; Bailey, I; Barberio, E; Barlow, R J; Batley, J Richard; Bechtle, P; Behnke, T; Bell, K W; Bell, P J; Bella, G; Bellerive, A; Benelli, G; Bethke, Siegfried; Biebel, O; Bock, P; Boeriu, O; Boutemeur, M; Braibant, S; Brigliadori, L; Brown, R M; Büsser, K; Burckhart, H J; Campana, S; Carnegie, R K; Caron, B; Carter, A A; Carter, J R; Chang, C Y; Charlton, D G; Csilling, A; Cuffiani, M; Dado, S; de Roeck, A; De Wolf, E A; Desch, Klaus; Dienes, B; Donkers, M; Dubbert, J; Duchovni, E; Duckeck, G; Duerdoth, I P; Etzion, E; Fabbri, F L; Feld, L; Ferrari, P; Fiedler, F; Fleck, I; Ford, M; Frey, A; Fürtjes, A; Gagnon, P; Gary, J W; Gaycken, G; Geich-Gimbel, C; Giacomelli, G; Giacomelli, P; Giunta, M; Goldberg, J; Gross, E; Grunhaus, Jacob; Gruwé, M; Günther, P O; Sen-Gupta, A; Hajdu, C; Hamann, M; Hanson, G G; Harder, K; Harel, A; Harin-Dirac, M; Hauschild, M; Hawkes, C M; Hawkings, R; Hemingway, R J; Hensel, C; Herten, G; Heuer, R D; Hill, J C; Hoffman, K; Horváth, D; Igo-Kemenes, P; Ishii, K; Jeremie, H; Jovanovic, P; Junk, T R; Kanaya, N; Kanzaki, J; Karapetian, G V; Karlen, D; Kawagoe, K; Kawamoto, T; Keeler, R K; Kellogg, R G; Kennedy, B W; Kim, D H; Klein, K; Klier, A; Kluth, S; Kobayashi, T; Kobel, M; Komamiya, S; Kormos, L; Kramer, T; Krieger, P; Krüger, K; Kühl, T; Kupper, M; Lafferty, G D; Landsman, H; Lanske, D; Layter, J G; Leins, A; Lellouch, D; Letts, J; Levinson, L; Lillich, J; Lloyd, S L; Loebinger, F K; Lü, J; Ludwig, J; MacPherson, A; Mader, W; Marcellini, S; Martin, A J; Masetti, G; Mashimo, T; Mättig, P; McDonald, W J; McKenna, J; McMahon, T J; McPherson, R A; Meijers, F; Menges, W; Merritt, F S; Mes, H; Michelini, A; Mihara, S; Mikenberg, G; Miller, D J; Moed, S; Mohr, W; Mori, T; Mutter, A; Nagai, K; Nakamura, I; Nanjo, H; Neal, H A; Nisius, R; O'Neale, S W; Oh, A; Okpara, A; Oreglia, M J; Orito, S; Pahl, C; Pásztor, G; Pater, J R; Patrick, G N; Pilcher, J E; Pinfold, J L; Plane, D E; Poli, B; Polok, J; Pooth, O; Przybycien, M B; Quadt, A; Rabbertz, K; Rembser, C; Renkel, P; Roney, J M; Rosati, S; Rozen, Y; Runge, K; Sachs, K; Saeki, T; Sarkisyan-Grinbaum, E; Schaile, A D; Schaile, O; Scharff-Hansen, P; Schieck, J; Schörner-Sadenius, T; Schröder, M; Schumacher, M; Schwick, C; Scott, W G; Seuster, R; Shears, T G; Shen, B C; Sherwood, P; Siroli, G; Skuja, A; Smith, A M; Sobie, R J; Söldner-Rembold, S; Spanó, F; Stahl, A; Stephens, K; Ströhmer, R; Strom, D; Tarem, S; Tasevsky, M; Taylor, R J; Teuscher, R; Thomson, M A; Torrence, E; Toya, D; Tran, P; Trigger, I; Trócsányi, Z L; Tsur, E; Turner-Watson, M F; Ueda, I; Ujvári, B; Vannerem, P; Vertesi, R; Verzocchi, M; Vollmer, C F; Voss, H; Vossebeld, Joost Herman; Waller, D; Ward, C P; Ward, D R; Watkins, P M; Watson, A T; Watson, N K; Wells, P S; Wengler, T; Wermes, N; Wetterling, D; Wilson, G W; Wilson, J A; Wolf, G; Wyatt, T R; Yamashita, S; Zer-Zion, D; Zivkovic, L; Von Krogh, J

2004-01-01

A study of W/sup +/W/sup -/ events accompanied by hard photon radiation, E/sub gamma />2.5 GeV, produced in e^{+}e^{-} collisions at LEP is presented. Events consistent with being two on- shell W-bosons and an isolated photon are selected from 681 pb/sup -1 / of data recorded at 180 GeV< square root s<209 GeV. From the sample of 187 selected W/sup +/W/sup -/ gamma candidates with photon energies greater than 2.5 GeV, the W/sup +/W/sup -/ gamma cross- section is determined at five values of square root s. The results are consistent with the standard model expectation. Averaging over all energies, the ratio of the observed cross-section to the standard model expectation is R(data/SM)=0.99+or-0.09+or-0.04, where the errors represent the statistical and systematic uncertainties respectively. These data provide constraints on the related O( alpha ) systematic uncertainties on the measurement of the W-boson mass at LEP. Finally, the data are used to derive 95% confidence level upper limits on possible anomalo...

Linearizing W-algebras

International Nuclear Information System (INIS)

Krivonos, S.O.; Sorin, A.S.

1994-06-01

We show that the Zamolodchikov's and Polyakov-Bershadsky nonlinear algebras W 3 and W (2) 3 can be embedded as subalgebras into some linear algebras with finite set of currents. Using these linear algebras we find new field realizations of W (2) 3 and W 3 which could be a starting point for constructing new versions of W-string theories. We also reveal a number of hidden relationships between W 3 and W (2) 3 . We conjecture that similar linear algebras can exist for other W-algebra as well. (author). 10 refs

76 FR 59481 - Fifty Eighth Meeting: RTCA Special Committee 135, Environmental Conditions and Test Procedures...

Science.gov (United States)

2011-09-26

... Meeting (RTCA Paper No. 166-11/SC 135-685). Review Approved Revised SC135 TOR (Terms of Reference..., RTCA Advisory Committee. [FR Doc. 2011-24637 Filed 9-23-11; 8:45 am] BILLING CODE 4910-13-P ...

Historia i znaczenie zbiorów Biblioteki Katedry Filologii Germańskiej Uniwersytetu Mikołaja Kopernika w Toruniu – depozyt w Bibliotece Uniwersyteckiej w Toruniu

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Wiesław Sieradzan

2014-12-01

Full Text Available Jedną z bardziej interesujących części zbiorów Biblioteki Głównej UMK jest znajdujący się tam od niedawna depozyt Biblioteki Katedry Filologii Germańskiej. Jego geneza łączy się nierozerwalnie z dziejami Uniwersytetu oraz samej Katedry, kształcącej germanistów już od ponad 40 lat. Celem autora jest poznanie tego księgozbioru, zarówno pod względem jego proweniencji, jak i wartości dla germanistów i historyków. Ważną kwestia jest ustalenie głównych twórców biblioteki germanistycznej po II wojnie światowej, jak również po reaktywacji Katedry Filologii Germańskiej w 1969 r. Depozyt Katedry Filologii Germańskiej w BG UMK liczy 7627 tomów. Już sam fakt sposobu jego powstawania, szczególnie po II wojnie światowej, głównie drogą zabezpieczania zbiorów poniemieckich, a ponadto zakupów i darów, musiał wpłynąć na różnorodność gatunkową oraz proweniencję. W depozycie daje się zauważyć mnogość ośrodków, z których nastąpiło rozproszenie zbiorów bibliotecznych. W ujęciu geograficznym jest to obszar od Greifswaldu na zachodzie po Królewiec na wschodzie. Od Gdańska i Słupska na północy aż po Dzierżoniów (Reichenbach, Świdnicę (Schweidnitz oraz Wrocław na południu. W księgozbiorze tym można wyróżnić prozę i poezję niemiecką ze szczególnym uwzględnieniem twórców z XIX i pierwszej połowy XX w., następnie opracowania krytyczne literatury niemieckiej, słowniki języka niemieckiego w tym rozmaitych jego dialektów.Ustalenia niewątpliwie autora potwierdzają tezę, że charakteryzowany księgozbiór ma niewątpliwie nie tylko ciekawą proweniencję, często udokumentowaną znakami własnościowymi w postaci pięknych exlibrisów lub superexlibrisów, ale przede wszystkim znaczną wagę dla filologów germańskich. Może bowiem stanowić cenną pomoc naukową dla badań językoznawczych i historycznych (historia Niemiec i Skandynawii. Kryje on jeszcze, pomimo powyższych ustale

135Cs/137Cs isotopic composition of environmental samples across Europe: Environmental transport and source term emission applications

International Nuclear Information System (INIS)

Snow, Mathew S.; Snyder, Darin C.

2016-01-01

135 Cs/ 137 Cs isotopic analyses represent an important tool for studying the fate and transport of radiocesium in the environment; in this work the 135 Cs/ 137 Cs isotopic composition in environmental samples taken from across Europe is reported. Surface soil and vegetation samples from western Russia, Ukraine, Austria, and Hungary show consistent aged thermal fission product 135 Cs/ 137 Cs isotope ratios of 0.58 ± 0.01 (age corrected to 1/1/15), with the exception of one sample of soil-moss from Hungary which shows an elevated 135 Cs/ 137 Cs ratio of 1.78 ± 0.12. With the exception of the outlier sample from Hungary, surface soil/vegetation data are in quantitative agreement with values previously reported for soils within the Chernobyl exclusion zone, suggesting that radiocesium at these locations is primarily composed of homogenous airborne deposition from Chernobyl. Seawater samples taken from the Irish Sea show 135 Cs/ 137 Cs isotope ratios of 1.22 ± 0.11 (age corrected to 1/1/15), suggesting aged thermal fission product Cs discharged from Sellafield. The differences in 135 Cs/ 137 Cs isotope ratios between Sellafield, Chernobyl, and global nuclear weapons testing fallout indicate that 135 Cs/ 137 Cs isotope ratios can be utilized to discriminate between and track radiocesium transport from different nuclear production source terms, including major emission sources in Europe. - Highlights: • 135 Cs/ 137 Cs useful for tracking anthropogenic environmental radiocesium releases. • European surface soils/vegetation have uniform ratio consistent with Chernobyl. • 135 Cs/ 137 Cs in Irish sea represents thermal fission ratio distinct from Chernobyl. • Can distinguish between major source terms in Europe based on 135 Cs/ 137 Cs.

PIERWIASTKI ŚLADOWE W WYBRANYCH WODACH MINERALNYCH DOSTĘPNYCH W HANDLU

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Adam Paweł PIECH

Full Text Available Butelkowane wody mineralne stanowią istotne źródło zaspokajania zapotrzebowania na wodę w codziennej diecie człowieka. Ze względu na łatwość przyswajania przez organizm składników mineralnych zawartych w wodach mineralnych konieczne jest świadome wybieranie produktu o składzie dostosowanym do indywidualnych potrzeb. Oprócz makroskładników, których charakterystyka ilościowa zawsze widnieje na etykietach, wody mineralne zawierają również mikroelementy. Celem pracy była analiza koncentracji pierwiastków śladowych w 22 butelkowanych wodach mineralnych dostępnych w handlu na terenie Rzeszowa. Artykuł zawiera główne zagadnienia dotyczące znaczenia wody dla prawidłowego funkcjonowania organizmu oraz wpływu mikroelementów na zdrowie człowieka. W badaniach zastosowano metodę całkowitego odbicia promieniowania rentgenowskiego TXRF. Analizy wykazały obecność 18 pierwiastków śladowych w badanych wodach: Al, As, Ba, Br, Co, Cr, Cu, Fe, Ge, I, Mn, Ni, P, Rb, Se, Sr, Ti, Zn. Najwyższe stężenia mikroskładników w przeważającej większości występują w wodach leczniczych. Żadna z badanych wód mogąca służyć jako stałe źródło płynów w diecie (wody nisko-, średnio- i wysokozmineralizowane nie zawiera mikroskładników w ilości, która pozwalałaby na fizjologiczno-odżywcze oddziaływanie na organizm. Dodatkowo wykazano, że pomiędzy stężeniem bromu i germanu istnieje silna korelacja dodatnia R2 = 0,993.

Compact 13.5-nm free-electron laser for extreme ultraviolet lithography

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Y. Socol

2011-04-01

Full Text Available Optical lithography has been actively used over the past decades to produce more and more dense integrated circuits. To keep with the pace of the miniaturization, light of shorter and shorter wavelength was used with time. The capabilities of the present 193-nm UV photolithography were expanded time after time, but it is now believed that further progress will require deployment of extreme ultraviolet (EUV lithography based on the use of 13.5-nm radiation. However, presently no light source exists with sufficient average power to enable high-volume manufacturing. We report here the results of a study that shows the feasibility of a free-electron laser EUV source driven by a multiturn superconducting energy-recovery linac (ERL. The proposed 40×20  m^{2} facility, using MW-scale consumption from the power grid, is estimated to provide about 5 kW of average EUV power. We elaborate the self-amplified spontaneous emission (SASE option, which is presently technically feasible. A regenerative-amplifier option is also discussed. The proposed design is based on a short-period (2–3 cm undulator. The corresponding electron beam energy is about 0.5–1.0 GeV. The proposed accelerator consists of a photoinjector, a booster, and a multiturn ERL.

PRZEBIEG SYMULACJI KOMPUTEROWEJ PROCESU OCZYSZCZANIA SCIEKÓW KOMUNALNYCH W REAKTORZE OSADU CZYNNEGO

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Zbigniew KOWALEWSKI

2016-05-01

Full Text Available Celem badań było ustalenie wpływu ilości i zakresu parametrów jakości ścieków surowych na wiarygodność wyników symulacji, co umożliwiłoby ustalenie optymalnej częstotliwości ich monitoringu, niezbędnego do pozyskiwania danych do modelowania w programach ASM. W artykule przedstawiono metodykę prowadzenia symulacji komputerowej procesu oczyszczania ścieków komunalnych w reaktorach biologicznych z osadem czynnym. Zaprezentowano sposób przygotowania i przetwarzania danych wejściowych do modelu oraz sposoby oceny i weryfikacji wyników symulacji za pomocą testów statystycznych. Modelowanie było wykonane w programie BioWin na przykładzie oczyszczalni ścieków komunalnych „Kujawy” w Krakowie. W oparciu o wstępne wyniki niniejszych badań można wnioskować, że w celu uzyskania wiarygodnych wyników symulacji pracy bioreaktora w modelu ASM niezbędne jest prowadzenie monitoringu podstawowych paramentów jakości ścieków online.

Rytuksymab – miejsce w leczeniu reumatoidalnego zapalenia stawów

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Małgorzata Tłustochowicz

2011-02-01

Full Text Available Rytuksymab jest przeciwciałem powodującym niszczenie limfocytówB zaangażowanych w proces zapalny w chorobach autoimmunologicznych.W reumatoidalnym zapaleniu stawów jest zalecanyu chorych, u których utrzymuje się aktywny proces zapalny, mimoleczenia klasycznymi lekami modyfikującymi przebieg chorobyi lekami anty-TNF-α. U tych chorych jest lekiem bardzo skutecznym,skuteczniejszym niż inny lek z grupy anty-TNF-α. Rytuksymabmoże być stosowany przez wiele lat, a jego skuteczność utrzymujesię na tym samym poziomie. Najczęstsze zdarzenia niepożądanewystępują w czasie wlewu leku, są one głównie związane z uwalnianiemcytokin z limfocytów B. Częstość i natężenie tych reakcjiznacznie się zmniejsza po premedykacji glikokortykosteroidami,a także przy kolejnych podaniach leku. Innymi powikłaniami sąinfekcje, ale ich liczba nie jest większa niż w populacji chorych nareumatoidalne zapalenie stawów. W artykule przedstawiono praktyczneaspekty kwalifikacji chorego do leczenia rytuksymabemoraz sposób przygotowania i podawania wlewu.

OBLICZENIE PRZEPŁYWÓW MAKSYMALNYCH I ICH REDUKCJI W ZLEWNI ZURBANIZOWANEJ

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Mariusz BARSZCZ

2016-03-01

Full Text Available W pracy przedstawiono wyniki zastosowania modelu SWMM do obliczenia przepływów o prawdopodobieństwach 50, 10, 2 i 1% w 8. przekrojach Potoku Służewieckiego na odcinku od km 0+000 do 6+576 oraz w 2. przekrojach Rowu Wolica. Zlewnia Potoku Służewieckiego jest zlokalizowana w południowej części Warszawy. Największe zagrożenie powodziowe występuje na odcinku Potoku Służewieckiego od km 0+000 do 3+875. Przepustowość koryta Potoku na tym odcinku kształtuje się na poziomie przepływu maksymalnego o prawdopodobieństwie 50%. Największe wartości przepływów w Potoku Służewieckim prognozowano w przekroju obliczeniowym numer V (km 4+267: Q50% = 13,863, Q10% = 23,019, Q2% = 28,825 i Q1% = 30,500 m3·s-1. Jedną z przyczyn występowania zagrożenia powodziowego w dolnym biegu Potoku Służewieckiego jest dopływ dużej ilości wód opadowych Rowem Wolica. Wartości przepływów w górnym odcinku Rowu Wolica (w przekroju VI zawierały się w granicach od 8,005 do 12,402 m3·s-1, w zależności od prawdopodobieństwa wystąpienia opadu obliczeniowego. W celu określenia możliwości redukcji przepływów w Rowie Wolica, przeprowadzono obliczenia w których uwzględniono zastosowanie kryzy na odcinku ujściowym kolektora do kanału otwartego. Zastosowanie kryzy w kolektorze pozwoli zredukować przepływy o prawdopodobieństwach 50, 10 i 2% odpowiednio o 61,0; 46,0 i 36,6%. Zastosowanie kryzy o stałej średnicy ϕ1,08 m, ustalonej dla przepływu o prawdopodobieństwie 2%, spowoduje znacznie mniejszą redukcję przepływów maksymalnych o prawdopodobieństwach 50 i 10%.

Scyntygrafia kości w diagnostyce reumatoidalnego zapalenia stawów

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Witold Tłustochowicz

2010-04-01

Full Text Available Celem pracy była ocena przydatności trójfazowej dynamicznejscyntygrafii kości w diagnostyce reumatoidalnego zapalenia stawów.Badaniem objęto 39 chorych hospitalizowanych i diagnozowanychz powodu dolegliwości stawowych. Przeprowadzono diagnostykęobejmującą: badanie podmiotowe, przedmiotowe, badania laboratoryjneoraz obrazowe, w tym trójfazową scyntygrafię kości z użyciemtechnetu 99m. Scyntygraficzne cechy zapalenia stawówstwierdzano, gdy obserwowano wzmożone gromadzenie znacznikawe wszystkich trzech fazach badania.Po ukończeniu diagnostyki rozpoznano u 13 chorych wczesne reumatoidalnezapalenie stawów, u 4 reumatoidalne zapalenie stawów(łącznie 17 pacjentów, a u 1 niezróżnicowane zapalenie stawów.Scyntygrafia kości wykazała cechy zapalenia stawów u 13spośród nich (72,2%, u 4 osób (22,2% wzmożone gromadzeniestwierdzono tylko w fazie statycznej, a u 1 pacjenta (5,6% uzyskanoprawidłowy wynik badania. U 21 chorych wykluczono chorobęzapalną stawów (u 19 rozpoznano fibromialgię, u 2 chorobęzwyrodnieniową. W grupie bez zapalenia stawów u 14 pacjentów(66,6% nie stwierdzono istotnych nieprawidłowości w obraziescyntygraficznym, u 6 (28,6% występowało wzmożone gromadzenieznacznika w badaniu statycznym, a u 1 chorego (4,8% opisanoscyntygraficzne cechy zapalenia stawów.Wbadanej grupie czułość scyntygrafii dynamicznej kości w wykrywaniuzapalenia stawów wynosiła 72,2% (95% CI: 57,5–76,8, a swoistość 95,2% (95% CI: 82,8–99,1. Dodatni wynik badaniadynamicznego wskazuje z dużym prawdopodobieństwem naobecność zapalenia stawów [PPV 92,9% (95% CI: 74,2–98,7].Mniej wiarygodny był ujemny wynik badania [NPV 80% (95% CI:69,5–83,3]. Wyniki niniejszej pracy wskazują, że trójfazowa scyntygrafia dynamicznakości może mieć zastosowanie w diagnostyce reumatoidalnegozapalenia stawów.

Sc-W-Si and Sc-W-Ge ternary systems

International Nuclear Information System (INIS)

Kotur, B.Ya.; Voznyak, O.M.; Bodak, O.I.

1989-01-01

Phase equilibria in Sc-W-Si and Sc-W-Ge ternary systems are investigated at 1070 K. Sc 2+x W 3-x Si 4 ternary compound (0≤x≤1) is determined, its crystal structure (Ce 2 Sc 3 Si 4 structural type), as well as, change of elementary cell parameters and microhardness within homogeneity range are determined. Regularities of component interaction within Sc-M-Si(Ge) (M-Cr, Mo, W) ternary system are determined. Ternary systems with Mo and W are more closer to each other according to the phase equilibria character, than to ternary systems with Cr

Budownictwo sakralne w diecezji łódzkiej w latach 1945-1989

OpenAIRE

Opaliński, Mateusz

2017-01-01

Tematem niniejszej rozprawy jest budownictwo sakralne w diecezji łódzkiej w latach 1945–1989. Omawiana kwestia jest emanacją ogólnego konfliktu między Kościołem rzymskokatolickim a władzami państwowymi w tzw. Polsce Ludowej. Potrzeba wznoszenia nowych miejsc sprawowania kultu religijnego była istotna z punktu widzenia Episkopatu, a także zasadna biorąc pod uwagę zmiany, jakie zaszły po 1945 r. w strukturze demograficznej i wyznaniowej. Wznoszenie obiektów sakralnych było wówczas znakiem zarów...

Wykorzystanie efficiency matrix w analizie zysku na pracownika (na przykładzie MŚP w sektorze informatycznym w Estonii

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Paavo Siimann

2015-10-01

Full Text Available Przedsiębiorstwa usługowe osiągają zyski dzięki wykorzystaniu zdolności i wiedzy pracowników. Stąd miara taka jak zysk na pracownika może być użyta w celu maksymalizacji wyników finansowych i wartości firmy. Artykuł obejmuje badanie z wykorzystaniem zmiennych: liczba pracowników, wysokość kapitału własnego, kapitału obcego, kosztów operacyjnych, przychodów netto ze sprzedaży oraz zysku przed opodatkowaniem w celu oszacowania ich wpływu na zmianę zysku na pracownika. Do próby badawczej wybrano małe i średnie przedsiębiorstwa z sektora informatycznego łącznie i jako osobne grupy. Badanie objęło lata 2009–2013. Co więcej, artykuł wskazuje, że metoda efficiency matrix rozwijana od początku lat 60. w Rosji i Estonii do lat 90. ubiegłego wieku może być stosowana także obecnie. Badania wykazały, że marża brutto oraz wartość kapitału własnego wzrastały gwałtownie w analizowanym okresie. Zysk na pracownika był mniejszy w średnich firmach, a większy w przedsiębiorstwach małych, podczas gdy kapitał własny na pracownika, przychody netto ze sprzedaży w stosunku do kosztów operacyjnych oraz marża brutto były mniejsze w małych firmach.

Przestrzeń liturgiczna w kaplicach krzyżackich domów zakonnych w Prusach - zarys problematyki

OpenAIRE

Rozynkowski, Waldemar

2018-01-01

Z założenia każdy krzyżacki dom zakonny pełnił przede wszystkim funkcje klasztorne. Chociaż w historiografii dominuje akcentowanie cech warownych tych miejsc, to jednak nie możemy mieć wątpliwości, że krzyżacki zamek tworzył wybraną przestrzeń, która miała ułatwić zakonnikom, zarówno kapłanom jak i braciom rycerzom, spełnianie obowiązków zakonnych oraz służyć organizacji życia wspólnotowego. W konsekwencji krzyżacki dom zakonny miał pomóc każdemu z jego mieszkańców w osiągnięciu zbawienia. ...

Hydrophilic Surface Modification of PDMS Microchannel for O/W and W/O/W Emulsions

Directory of Open Access Journals (Sweden)

Shazia Bashir

2015-09-01

Full Text Available A surface modification method for bonded polydimethylsiloxane (PDMS microchannels is presented herein. Polymerization of acrylic acid was performed on the surface of a microchannel using an inline atmospheric pressure dielectric barrier microplasma technique. The surface treatment changes the wettability of the microchannel from hydrophobic to hydrophilic. This is a challenging task due to the fast hydrophobic recovery of the PDMS surface after modification. This modification allows the formation of highly monodisperse oil-in-water (O/W droplets. The generation of water-in-oil-in-water (W/O/W double emulsions was successfully achieved by connecting in series a hydrophobic microchip with a modified hydrophilic microchip. An original channel blocking technique to pattern the surface wettability of a specific section of a microchip using a viscous liquid comprising a mixture of honey and glycerol, is also presented for generating W/O/W emulsions on a single chip.

29 CFR 1615.135 - Electronic and information technology requirements.

Science.gov (United States)

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false Electronic and information technology requirements. 1615... INFORMATION TECHNOLOGY § 1615.135 Electronic and information technology requirements. (a) Development, procurement, maintenance, or use of electronic and information technology.—When developing, procuring...

33 CFR 135.219 - Notification of changes affecting certification.

Science.gov (United States)

2010-07-01

... SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND Financial Responsibility for Offshore Facilities § 135.219 Notification of changes affecting... Fund Administrator in writing when any changes occur which prevent the owner, operator, or guarantor...

Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS.

Directory of Open Access Journals (Sweden)

Abdelali Daddaoua

Full Text Available Homologs of the transcriptional regulator PtxS are omnipresent in Pseudomonas, whereas PtxR homologues are exclusively found in human pathogenic Pseudomonas species. In all Pseudomonas sp., PtxS with 2-ketogluconate is the regulator of the gluconate degradation pathway and controls expression from its own promoter and also from the P(gad and P(kgu for the catabolic operons. There is evidence that PtxS and PtxR play a central role in the regulation of exotoxin A expression, a relevant primary virulence factor of Pseudomonas aeruginosa. We show using DNaseI-footprint analysis that in P. aeruginosa PtxR binds to the -35 region of the P(toxA promoter in front of the exotoxin A gene, whereas PtxS does not bind to this promoter. Bioinformatic and DNaseI-footprint analysis identified a PtxR binding site in the P(kgu and P(gad promoters that overlaps the -35 region, while the PtxS operator site is located 50 bp downstream from the PtxR site. In vitro, PtxS recognises PtxR with nanomolar affinity, but this interaction does not occur in the presence of 2-ketogluconate, the specific effector of PtxS. DNAaseI footprint assays of P(kgu and P(gad promoters with PtxS and PtxR showed a strong region of hyper-reactivity between both regulator binding sites, indicative of DNA distortion when both proteins are bound; however in the presence of 2-ketogluconate no protection was observed. We conclude that PtxS modulates PtxR activity in response to 2-ketogluconate by complex formation in solution in the case of the P(toxA promoter, or via the formation of a DNA loop as in the regulation of gluconate catabolic genes. Data suggest two different mechanisms of control exerted by the same regulator.

Development of a short-term (<12 days), plant-based screening method to assess the bioavailability, bioconcentration, and phytotoxicity of Hexahydro-1,3,5- Trinitro-1,3,5-Tiazine (RDZ) to terrestrial plants

Science.gov (United States)

Linda Winfield; Steven D' Surney; John Rodgers

2000-01-01

Limited amounts of information have been published on the environmental impacts of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) to terrestrial plant communities. RDX is one of the two high-explosive compounds used by the U.S. military (Davis 1998) and classified as a priority pollutant by the U.S. Environmental Protection Agency (USEPA). Millions of acres of land on...

Raport z badania 2016. Specjalne Strefy Ekonomiczne w Polsce w oczach przedsiębiorców i pracowników samorządów

OpenAIRE

Pastusiak, Radosław; Jasiniak, Magdalena; Keller, Jakub; Krzeczewski, Bartłomiej

2016-01-01

Niniejszy raport prezentuje wyniki projektu realizowanego w ramach projektu badawczego nr UMO-2013/09/B/HS4/, pt. Efektywność Specjalnych Stref Ekonomicznych, przez zespół Katedry Finansów Korporacji, Wydział Ekonomiczno-Socjologiczny Uniwersytetu Łódzkiego, pod kierownictwem dr hab. Radosława Pastusiaka, prof. nadzw. UŁ. w składzie: dr Magdalena Jasiniak, mgr Jakub Keller, mgr Bartłomiej Krzeczewski. Zasadniczym celem badania było określenie efektywności funkcjonowania Specjalnych Stref Ekon...

Lenin w Anglii

Directory of Open Access Journals (Sweden)

Mario Tronti

2016-06-01

Full Text Available Lenin w Anglii to słynny tekst Trontiego otwierający pierwszy numer czasopisma Classe operaia, założonego po tym, jak Tronti wraz ze współpracownikami zerwał ze środowiskiem pierwszego operaizmu skupionego wokół Quaderni Rossi. To właśnie w tym tekście Tronti sformułował słynny „kopernikański zwrot w marksizmie”, zgodnie z którym punktem wyjścia analizy rzeczywistości społecznej i historii kapitalizmu powinna być walka klasy robotniczej, a nie prawa rozwoju kapitału. Do zdefiniowania zwrotu popchnęła Trontiego przedstawiona w tekście diagnoza sytuacji włoskiej klasy robotniczej w latach 60. Kontrowersyjne tezy Trontiego i jego radykalna postawa wpłynęły znacząco na dyskusje prowadzone na radykalnej włoskiej lewicy i na działania wielu aktywistów w latach 60. i 70.

Signatures of Parton Exogamy in e+ e- -> W+ W- -> hadrons

OpenAIRE

Ellis, John; Geiger, Klaus

1997-01-01

We propose possible signatures of `exogamous' combinations between partons in the different W+ and W- hadron showers in e+e- -> W+W- events with purely hadronic final states. Within the space-time model for hadronic shower development that we have proposed previously, we find a possible difference of about 10 % between the mean hadronic multiplicity in such purely hadronic final states and twice the hadronic multiplicity in events in which one W decays hadronically and the other leptonically,...

Physical states and scaling properties of W gravities and W strings

International Nuclear Information System (INIS)

Das, S.R.; Dhar, A.; Rama, S.K.

1992-01-01

In this paper the authors discuss some physical aspects of W gravities and W strings. The authors identify global characteristics in W gravities (in addition to the usual Euler characteristic) and show how the dependence of the partition function on the various chemical potentials involves these quantities. The authors find the operators which create physical states in W 3 and W 4 gravities and discuss their relationship with screening operators. W strings are discussed in the framework of a natural way of coupling matter to W gravity, and the issues of extra dimensions and critical dimensions are clarified. The authors find a remarkable relationship between pure W gravities and ordinary gravity coupled to c < 1 unitary minimal models

Etyka w zawodzie specjalisty rachunkowości zarządczej w podręcznikach i kształceniu w Polsce

Directory of Open Access Journals (Sweden)

Irena Sobańska

2016-07-01

Full Text Available Celem artykułu jest poznanie, jak środowisko naukowe rachunkowości wspiera zawód specjalisty ra- chunkowości zarządczej w uświadamianiu wysokich wymagań etycznych oczekiwanych od tego zawo- du. W artykule zostały przedstawione zagadnienia dotyczące etyki w zawodzie specjalisty rachunkowości zarządczej w świetle badań i standardów międzynarodowych oraz wyniki i wnioski z badań treści pol- skich podręczników akademickich i programów kształcenia. Przeprowadzone badania pozwoliły pozy- tywnie zweryfikować postawioną hipotezę, mówiącą, że w procesie kształcenia akademickiego zagad- nienia etyki zawodu specjalisty rachunkowości zarządczej nie są w ogóle lub w minimalnym zakresie objaśniane. Stanowi to wskazówkę do udoskonalenia programów kształcenia w badanym zakresie na uczelniach wyższych w Polsce.

Study of Spin and Decay-Plane Correlations of W Bosons in the $e^{+} e^{-} \\to W^{+} W^{-}$ Process at LEP

CERN Document Server

Achard, P; Aguilar-Benítez, M; Alcaraz, J; Alemanni, G; Allaby, James V; Aloisio, A; Alviggi, M G; Anderhub, H; Andreev, V P; Anselmo, F; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Bajo, A; Baksay, G; Baksay, L; Baldew, S V; Banerjee, S; Banerjee, Sw; Barczyk, A; Barillère, R; Bartalini, P; Basile, M; Batalova, N; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Bellucci, L; Berbeco, R; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Biasini, M; Biglietti, M; Biland, A; Blaising, J J; Blyth, S C; Bobbink, G J; Böhm, A; Boldizsar, L; Borgia, B; Bottai, S; Bourilkov, D; Bourquin, Maurice; Braccini, S; Branson, J G; Brochu, F; Burger, J D; Burger, W J; Cai, X D; Capell, M; Cara Romeo, G; Carlino, G; Cartacci, A; Casaus, J; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada, M; Chamizo-Llatas, M; Chang, Y H; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chiefari, G; Cifarelli, Luisa; Cindolo, F; Clare, I; Clare, R; Coignet, G; Colino, N; Costantini, S; de la Cruz, B; Cucciarelli, S; van Dalen, J A; De Asmundis, R; Déglon, P L; Debreczeni, J; Degré, A; Dehmelt, K; Deiters, K; Della Volpe, D; Delmeire, E; Denes, P; De Notaristefani, F; De Salvo, A; Diemoz, M; Dierckxsens, M; Dionisi, C; Dittmar, M; Doria, A; Dova, M T; Duchesneau, D; Duda, M; Echenard, B; Eline, A; El-Hage, A; El-Mamouni, H; Engler, A; Eppling, F J; Extermann, P; Falagán, M A; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, M; Ferguson, T; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, F; Fisher, P H; Fisher, W; Fisk, I; Forconi, G; Freudenreich, Klaus; Furetta, C; Galaktionov, Yu; Ganguli, S N; García-Abia, P; Gataullin, M; Gentile, S; Giagu, S; Gong, Z F; Grenier, G; Grimm, O; Grünewald, M W; Guida, M; van Gulik, R; Gupta, V K; Gurtu, A; Gutay, L J; Haas, D; Hatzifotiadou, D; Hebbeker, T; Hervé, A; Hirschfelder, J; Hofer, H; Hohlmann, M; Holzner, G; Hou, S R; Hu, Y; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Kaur, M; Kienzle-Focacci, M N; Kim, J K; Kirkby, Jasper; Kittel, E W; Klimentov, A; König, A C; Kopal, M; Koutsenko, V F; Kraber, M; Krämer, R W; Krüger, A; Kunin, A; Ladrón de Guevara, P; Laktineh, I; Landi, G; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Le Goff, J M; Leiste, R; Levtchenko, M; Levchenko, P M; Li, C; Likhoded, S; Lin, C H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lü, Y S; Luci, C; Luminari, L; Lustermann, W; Ma Wen Gan; Malgeri, L; Malinin, A; Maña, C; Mans, J; Martin, J P; Marzano, F; Mazumdar, K; McNeil, R R; Mele, S; Merola, L; Meschini, M; Metzger, W J; Mihul, A; Milcent, H; Mirabelli, G; Mnich, J; Mohanty, G B; Muanza, G S; Muijs, A J M; Musicar, B; Musy, M; Nagy, S; Natale, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Nisati, A; Novák, T; Nowak, H; Ofierzynski, R A; Organtini, G; Pal, I; Palomares, C; Paolucci, P; Paramatti, R; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Pedace, M; Pensotti, S; Perret-Gallix, D; Petersen, B; Piccolo, D; Pierella, F; Pioppi, M; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Pothier, J; Prokofev, D; Prokofiev, D O; Quartieri, J; Rahal-Callot, G; Rahaman, M A; Raics, P; Raja, N; Ramelli, R; Rancoita, P G; Ranieri, R; Raspereza, A V; Razis, P; Ren, D; Rescigno, M; Reucroft, S; Riemann, S; Riles, K; Roe, B P; Romero, L; Rosca, A; Rosemann, C; Rosenbleck, C; Rosier-Lees, S; Roth, S; Rubio, J A; Ruggiero, G; Rykaczewski, H; Sakharov, A; Saremi, S; Sarkar, S; Salicio, J; Sánchez, E; Schäfer, C; Shchegelskii, V; Schopper, Herwig Franz; Schotanus, D J; Sciacca, C; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shumilov, E; Shvorob, A; Son, D; Souga, C; Spillantini, P; Steuer, M; Stickland, D P; Stoyanov, B; Strässner, A; Sudhakar, K; Sultanov, G G; Sun, L Z; Sushkov, S; Suter, H; Swain, J D; Szillási, Z; Tang, X W; Tarjan, P; Tauscher, L; Taylor, L; Tellili, B; Teyssier, D; Timmermans, C; Ting, Samuel C C; Ting, S M; Tonwar, S C; Tóth, J; Tully, C; Tung, K L; Ulbricht, J; Valente, E; Van de Walle, R T; Vásquez, R; Veszpremi, V; Vesztergombi, G; Vetlitskii, I; Vicinanza, D; Viertel, Gert M; Villa, S; Vivargent, M; Vlachos, S; Vodopyanov, I; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Wadhwa, M; Wang, Q; Wang, X L; Wang, Z M; Weber, M; Wilkens, H; Wynhoff, S; Xia, L; Xu, Z Z; Yamamoto, J; Yang, B Z; Yang, C G; Yang, H J; Yang, M; Yeh, S C; Zalite, A; Zalite, Yu; Zhang, Z P; Zhao, J; Zhu, G Y; Zhu, R Y; Zhuang, H L; Zichichi, A; Zimmermann, B; Zöller, M

2005-01-01

Data collected at LEP at centre-of-mass energies \\sqrt(s) = 189 - 209 GeV are used to study correlations of the spin of W bosons using e+e- -> W+W- -> lnqq~ events. Spin correlations are favoured by data, and found to agree with the Standard Model predictions. In addition, correlations between the W-boson decay planes are studied in e+e- -> W+W- -> lnqq~ and e+e- -> W+W- -> qq~qq~ events. Decay-plane correlations, consistent with zero and with the Standard Model predictions, are measured.

Synthesis and inhibitory effect on photosynthetic electron transport of 1,3,5-triazinylcarboxylic acid derivatives

NARCIS (Netherlands)

Fujimori, A.; Ikeda, Y.; Okano, R.; Hiraki, M.; Rensen, van J.J.S.; Boger, P.; Kohno, H.; Wakabayashi, K.

2005-01-01

This study relates to the modification of 2-benzylamino-4-methyl-6-trifluoromethyl-1,3,5-triazine. New 1,3,5-triazine compounds with an electron-withdrawing carboxyl group, e.g. ester group, substituted for the trifluoromethyl group, were synthesized and assayed for activity to inhibit

Potencjał olejków eterycznych w profilaktyce i terapii grzybic

Directory of Open Access Journals (Sweden)

Monika Sienkiewicz

2008-10-01

Full Text Available Silne właściwości antyseptyczne olejków eterycznych znane są od wielu wieków. Są one produktami metabolizmu wtórnego roślin. Olejki eteryczne i ich składniki wykazują działanie hamujące wzrost wobec bakterii, grzybów, wirusów i pierwotniaków. Ich aktywność przeciwdrobnoustrojowa jest ściśle związana ze składem chemicznym. Do tej pory nie odnotowano doniesień o rosnącej oporności szczepów bakterii i grzybów na składniki olejków. Olejki eteryczne wykazują m.in. właściwości przeciwzapalne, przeciwbólowe i antyoksydacyjne. Do najbardziej skutecznych olejków o najsilniejszych właściwościach przeciwgrzybiczych należą olejki pozyskiwane z drzewa herbacianego, tymianku, oregano, cząbru, bazylii, szałwi, goździkowca i cynamonowca. Największą aktywnością charakteryzują się olejki zawierające fenole – tymol, karwakrol i eugenol. Olejki tymiankowy, oreganowy i cząbrowy zawierają tymol i karwakrol, natomiast pozyskiwane z goździkowca i z liści cynamonowca zawierają eugenol. Jeden z najbardziej efektywnych olejków jest pozyskiwany z drzewa herbacianego (Melaleuca alternifolia. Olejek ten wykazuje wysoką aktywność wobec Candida sp., Trichophyton sp. i Microsporum sp. Olejki tymiankowy, oreganowy i rozmarynowy ze względu na szerokie spektrum aktywności mogą być polecane w leczeniu zakażeń wywoływanych przez Candida albicans, Trichophyton sp., Epidermophyton floccosum i Microsporum canis. Olejek goździkowy i cynamonowy z liści wykazują znaczące działanie hamujące wobec Aspergillus flavus, Aspergillus parasiticus, Candida albicans i Cryptococcus neoformans. Olejki eteryczne oraz ich składniki mogą posiadać silne działanie immunostymulujące, zaliczamy do nich: olejek sosnowy, cytrynowy, geraniowy, a-pinen. Olejki eteryczne znalazły zastosowanie w leczeniu infekcji dermatologicznych pochodzenia grzybiczego. Dobre wyniki przynosi również stosowanie olejków w ginekologii i w terapii

On colour rearrangement in hadronic W+W- events

International Nuclear Information System (INIS)

Sjoestrand, T.; Khoze, V.A.

1994-01-01

We discuss the possibility of colour rearrangement in e + e - →W + W - →q 1 anti q 2 q 3 anti q 4 events, i.e. that the original colour singlets q 1 anti q 2 and q 3 anti q 4 may be transmuted, for instance, into new singlets q 1 anti q 4 and q 3 anti q 2 . The effects on event properties could be quite large if such a rearrangement would occur instantaneously, so that gluon emission would be restricted to each of the new singlets separately. We argue that such a scenario is unlikely for two reasons. Firstly, the W + and W - usually decay at separate times after the W + W - production, which leads to large relative phases for energetic radiation off the two constituents of a rearranged system, and a corresponding dampening of the QCD cascades. Secondly, within the perturbative scenario the colour transmutation appears only in order α s 2 and is colour-suppressed. Colour reconnection at longer time scales is quite feasible, however, and may affect the fragmentation phase. If so, the nature of non-perturbative QCD can be probed in a new way. We formulate several alternative toy models and use these to estimate the colour reconnection probability as a function of the event kinematics. Possible consequences for LEP 2 events are illustrated, with special attention to systematic errors in W mass determinations. (orig.)

Superconductivity in the W-Tc and W2C-Tc systems

International Nuclear Information System (INIS)

Giorgi, A.L.

1985-01-01

A series of compositions in the W-Tc, W 2 C-Re and W 2 C-Tc systems were prepared and examined for superconductivity. The crystal structure, lattice parameters and superconducting transition temperatures of the W 2 C-Tc are reported for the first time. Similar measurements were made on the W-Tc and W 2 C-Re systems and the results compared with previous published results for these systems. 7 refs., 2 figs., 2 tabs

14 CFR 135.175 - Airborne weather radar equipment requirements.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Airborne weather radar equipment... Aircraft and Equipment § 135.175 Airborne weather radar equipment requirements. (a) No person may operate a large, transport category aircraft in passenger-carrying operations unless approved airborne weather...

14 CFR 135.173 - Airborne thunderstorm detection equipment requirements.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Airborne thunderstorm detection equipment... Aircraft and Equipment § 135.173 Airborne thunderstorm detection equipment requirements. (a) No person may... the aircraft is equipped with either approved thunderstorm detection equipment or approved airborne...

Activity profiles of 309 ToxCastTM chemicals evaluated across 292 biochemical targets

International Nuclear Information System (INIS)

Knudsen, Thomas B.; Houck, Keith A.; Sipes, Nisha S.; Singh, Amar V.; Judson, Richard S.; Martin, Matthew T.; Weissman, Arthur; Kleinstreuer, Nicole C.; Mortensen, Holly M.; Reif, David M.; Rabinowitz, James R.; Setzer, R. Woodrow; Richard, Ann M.; Dix, David J.; Kavlock, Robert J.

2011-01-01

Understanding the potential health risks posed by environmental chemicals is a significant challenge elevated by the large number of diverse chemicals with generally uncharacterized exposures, mechanisms, and toxicities. The present study is a performance evaluation and critical analysis of assay results for an array of 292 high-throughput cell-free assays aimed at preliminary toxicity evaluation of 320 environmental chemicals in EPA's ToxCast TM project (Phase I). The chemicals (309 unique, 11 replicates) were mainly precursors or the active agent of commercial pesticides, for which a wealth of in vivo toxicity data is available. Biochemical HTS (high-throughput screening) profiled cell and tissue extracts using semi-automated biochemical and pharmacological methodologies to evaluate a subset of G-protein coupled receptors (GPCRs), CYP450 enzymes (CYPs), kinases, phosphatases, proteases, HDACs, nuclear receptors, ion channels, and transporters. The primary screen tested all chemicals at a relatively high concentration 25 μM concentration (or 10 μM for CYP assays), and a secondary screen re-tested 9132 chemical-assay pairs in 8-point concentration series from 0.023 to 50 μM (or 0.009-20 μM for CYPs). Mapping relationships across 93,440 chemical-assay pairs based on half-maximal activity concentration (AC50) revealed both known and novel targets in signaling and metabolic pathways. The primary dataset, summary data and details on quality control checks are available for download at (http://www.epa.gov/ncct/toxcast/).

Trinuclear Lanthanoid Complexes of 1,3,5-Triamino-1,3,5-trideoxy-cis-inositol with a Unique, Sandwich-Type Cage Structure(1).

Science.gov (United States)

Hedinger, Roman; Ghisletta, Michele; Hegetschweiler, Kaspar; Tóth, Eva; Merbach, André E.; Sessoli, Roberta; Gatteschi, Dante; Gramlich, Volker

1998-12-28

A variety of trinuclear complexes [M(3)(H(-)(3)L)(2)](3+) [M = Y, La, Eu, Gd, Dy; L = 1,3,5-triamino-1,3,5-trideoxy-cis-inositol (taci) and 1,3,5-trideoxy-1,3,5-tris(dimethylamino)-cis-inositol (tdci)] was prepared as solid materials of the composition M(3)(H(-)(3)L)(2)X(3).pH(2)O.qEtOH (X = Cl, NO(3); 2.5

Przekształcenia przestrzenne i funkcjonalne obszarów przemysłowych w miastach brytyjskich. Przykład Doków w Londynie

OpenAIRE

Kaczmarek, Sylwia

1999-01-01

Materiały wykorzystane w tym opracowaniu autorka zebrała w Londynie podczas wizyty studialnej w Wielkiej Brytanii, finansowanej przez British Council, która odbyła się w październiku 1994 r. Recently the main aspect of British spatial and economic planning was what came to be known as inner city problem. It began around mid 1960s when a lot of traditional industries in cities declined (examples of Glasgow, Manchester, London). The case of London Docklands illustrates the cru...

Study of spin and decay-plane correlations of W bosons in the e+e-→W+ W- process at LEP

International Nuclear Information System (INIS)

Achard, P.; Adriani, O.; Aguillar-Benitez, M.

2005-01-01

Data collected at LEP at centre-of-mass energies √(s)=189-209 GeV are used to study correlations of the spin of W bosons using e + e - →W + W - →lνq anti q events. Spin correlations are favoured by data, and found to agree with the Standard Model predictions. In addition, correlations between the W-boson decay planes are studied in e + e - →W + W - →lνq anti q and e + e - →W + W - →q anti qq anti q events. Decay-plane correlations are measured to be consistent with the Standard Model predictions. (orig.)

14 CFR 135.207 - VFR: Helicopter surface reference requirements.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false VFR: Helicopter surface reference... VFR/IFR Operating Limitations and Weather Requirements § 135.207 VFR: Helicopter surface reference requirements. No person may operate a helicopter under VFR unless that person has visual surface reference or...

Can T1 w/T2 w ratio be used as a myelin-specific measure in subcortical structures? Comparisons between FSE-based T1 w/T2 w ratios, GRASE-based T1 w/T2 w ratios and multi-echo GRASE-based myelin water fractions.

Science.gov (United States)

Uddin, Md Nasir; Figley, Teresa D; Marrie, Ruth Ann; Figley, Chase R

2018-03-01

Given the growing popularity of T 1 -weighted/T 2 -weighted (T 1 w/T 2 w) ratio measurements, the objective of the current study was to evaluate the concordance between T 1 w/T 2 w ratios obtained using conventional fast spin echo (FSE) versus combined gradient and spin echo (GRASE) sequences for T 2 w image acquisition, and to compare the resulting T 1 w/T 2 w ratios with histologically validated myelin water fraction (MWF) measurements in several subcortical brain structures. In order to compare these measurements across a relatively wide range of myelin concentrations, whole-brain T 1 w magnetization prepared rapid acquisition gradient echo (MPRAGE), T 2 w FSE and three-dimensional multi-echo GRASE data were acquired from 10 participants with multiple sclerosis at 3 T. Then, after high-dimensional, non-linear warping, region of interest (ROI) analyses were performed to compare T 1 w/T 2 w ratios and MWF estimates (across participants and brain regions) in 11 bilateral white matter (WM) and four bilateral subcortical grey matter (SGM) structures extracted from the JHU_MNI_SS 'Eve' atlas. Although the GRASE sequence systematically underestimated T 1 w/T 2 w values compared to the FSE sequence (revealed by Bland-Altman and mountain plots), linear regressions across participants and ROIs revealed consistently high correlations between the two methods (r 2 = 0.62 for all ROIs, r 2 = 0.62 for WM structures and r 2 = 0.73 for SGM structures). However, correlations between either FSE-based or GRASE-based T 1 w/T 2 w ratios and MWFs were extremely low in WM structures (FSE-based, r 2 = 0.000020; GRASE-based, r 2 = 0.0014), low across all ROIs (FSE-based, r 2 = 0.053; GRASE-based, r 2 = 0.029) and moderate in SGM structures (FSE-based, r 2 = 0.20; GRASE-based, r 2 = 0.17). Overall, our findings indicated a high degree of correlation (but not equivalence) between FSE-based and GRASE-based T 1 w/T 2 w ratios, and low correlations between T 1 w/T 2 w ratios and MWFs. This

41 CFR 102-74.135 - Who selects construction and alteration projects that are to be performed?

Science.gov (United States)

2010-07-01

... and alteration projects that are to be performed? 102-74.135 Section 102-74.135 Public Contracts and... construction and alteration projects that are to be performed? The Administrator of General Services selects construction and alteration projects to be performed. ...

Employing organizational modeling and simulation of the KC-135 depot's flight controls repair cell

OpenAIRE

Paskin, Matthew A.; Trevino, Alice W.; Ferrer, Geraldo; Dillard, John T.

2008-01-01

Today’s environment of increased operations tempo is stressing the KC- 135 Stratotanker fleet. With an 80-year life span expectancy, effectively maintaining these aircraft is challenging. This research modeled the KC- 135 programmed depot maintenance (PDM) flight controls repair cell to identify improvement opportunities within the repair process. Computational organizational modeling (COM) incorporates the human element along with organizational design theory. By employing ...

Michał Kalecki i problem racjonalnej alokacji zasobów w socjalizmie

Directory of Open Access Journals (Sweden)

Damian Winczewski

2015-06-01

Full Text Available Celem artykułu jest rekonstrukcja poglądów Michała Kaleckiego i jego zwolenników na temat racjonalnej kalkulacji i alokacji zasobów w gospodarce socjalistycznej, a także próba zestawienia tych poglądów z poglądami zwolenników zarówno kapitalizmu, jak i alternatywnych modeli socjalizmu. Pod tym kątem przeanalizowano artykuły polskiego ekonomisty dotyczące schematu tworzenia się cen w kapitalizmie i socjalizmie, roli klasy robotniczej oraz systemu bodźców i sposobu zarządzania gospodarką. W artykule omówiono też poglądy autorów, którzy bazując na pracach Kaleckiego, podjęli się polemiki z obiegową narracją wyjaśniającą porażkę realnego socjalizmu. Zarówno realny kapitalizm, jak i realny socjalizm zmagają się z problemami niedoskonałej informacji i miękkich budżetów, nie istnieje również doskonały model zarządzania gospodarką, w związku z tym nie są to bezpośrednie przyczyny niepowodzenia projektu socjalistycznego. Oprócz problemu innowacji i optymalnych nakładów inwestycyjnych z perspektywy kaleckiańskiej zasadniczym problemem socjalizmu wydaje się ustanowienie właściwych stosunków produkcji w marksistowskim sensie, rozumianych jako zdemokratyzowanie relacji pomiędzy klasą robotniczą a warstwą zarządzającą produkcją.

Comparison of xenon-135 and samarium-149 poisoning in the Miniature Neutron Source Reactor

International Nuclear Information System (INIS)

Khattab, K.

2005-05-01

The Xe-135 equilibrium reactivity was calculated previously using the WIMSD4 and CITATION codes to estimate the fission product poisoning factor in the Syrian Miniature Neutron Source Reactor (MNSR). The fission product poisoning factor was used to calculate the Xe-135 concentrations and reactivities during the reactor operation, at saturation, and after shutdown. The fission product poisoning factor is used in this study to calculate the Sm-149 concentrations and reactivities during the reactor operation, at saturation, and after shutdown. The results are compared with Xe-135 concentrations and reactivities which were calculated before. The Xe-135 concentration increases versus the reactor operation time and reaches 2.836*10 13 atoms/cm 3 after 6 hours, where the Sm-149 concentration reaches 0.745*10 12 atoms/cm 3 . The Xe-135 and Sm-149 reactivities reach -0.451 and -0.256*10 -3 mk respectively after 6 hours of the reactor operation time. It is found that the Xe-135 and Sm-149 reactivities do not reach the equilibrium reactivities during typical reactor daily operating time. The Xe-235 concentration and reactivity are increased and reach to maximum values after 30000 second from the reactor shut down. Its maximum reactivity is -0.903 mk. Hence, the Xe-235 generates -0.452 mk extra reactivity after the reactor shutdown. The Sm-149 concentration and reactivates are increased after the reactor shut down. The Sm-149 reactivity reaches -0.249*10 -2 mk after 100000 second from the reactor shut down, and the Sm-149 introduces -2.231*10 -3 mk extra reactivity after the reactor shut down. Finally, the amount of Sm-149 accumulated in the reactor core after 1, 2, 5, and 10 years of the reactor operation time are: 3.995*10 -3 , 7.694*10 -3 , 17.226*10 -3 , and 2.892*10 -2 grams respectively. (Author)

33 CFR 135.401 - Access to vessel, Certificates of Financial Responsibility.

Science.gov (United States)

2010-07-01

... HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND Access, Denial, and Detention § 135.401 Access to vessel, Certificates of...

A test of unification towards the radio source PKS1413+135

International Nuclear Information System (INIS)

Ferreira, M.C.; Julião, M.D.; Martins, C.J.A.P.; Monteiro, A.M.R.V.L.

2013-01-01

We point out that existing astrophysical measurements of combinations of the fine-structure constant α, the proton-to-electron mass ratio μ and the proton gyromagnetic ratio g p towards the radio source PKS1413+135 can be used to individually constrain each of these fundamental couplings. While the accuracy of the available measurements is not yet sufficient to test the spatial dipole scenario, our analysis serves as a proof of concept as new observational facilities will soon allow significantly more robust tests. Moreover, these measurements can also be used to obtain constraints on certain classes of unification scenarios, and we compare the constraints obtained for PKS1413+135 with those previously obtained from local atomic clock measurements

A test of unification towards the radio source PKS1413+135

Energy Technology Data Exchange (ETDEWEB)

Ferreira, M.C., E-mail: up200802537@fc.up.pt [Centro de Astrofísica, Universidade do Porto, Rua das Estrelas, 4150-762 Porto (Portugal); Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, 4150-007 Porto (Portugal); Julião, M.D., E-mail: meinf12013@fe.up.pt [Centro de Astrofísica, Universidade do Porto, Rua das Estrelas, 4150-762 Porto (Portugal); Faculdade de Engenharia, Universidade do Porto, Rua Dr Roberto Frias, 4200-465 Porto (Portugal); Martins, C.J.A.P., E-mail: Carlos.Martins@astro.up.pt [Centro de Astrofísica, Universidade do Porto, Rua das Estrelas, 4150-762 Porto (Portugal); Monteiro, A.M.R.V.L., E-mail: mmonteiro@fc.up.pt [Centro de Astrofísica, Universidade do Porto, Rua das Estrelas, 4150-762 Porto (Portugal); Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, 4150-007 Porto (Portugal); Department of Applied Physics, Delft University of Technology, P.O. Box 5046, 2600 GA Delft (Netherlands)

2013-07-09

We point out that existing astrophysical measurements of combinations of the fine-structure constant α, the proton-to-electron mass ratio μ and the proton gyromagnetic ratio g{sub p} towards the radio source PKS1413+135 can be used to individually constrain each of these fundamental couplings. While the accuracy of the available measurements is not yet sufficient to test the spatial dipole scenario, our analysis serves as a proof of concept as new observational facilities will soon allow significantly more robust tests. Moreover, these measurements can also be used to obtain constraints on certain classes of unification scenarios, and we compare the constraints obtained for PKS1413+135 with those previously obtained from local atomic clock measurements.

24 CFR 35.135 - Use of paint containing lead.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Use of paint containing lead. 35... Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES General Lead-Based Paint Requirements and Definitions for All Programs. § 35.135 Use of paint containing lead. (a...

Wielokryterialna ocena różnych wariantów lokalizacji ujęcia wód podziemnych dla oczyszczalni ścieków w Częstochowie

Directory of Open Access Journals (Sweden)

Łukasz Kaczmarek

2015-03-01

Full Text Available Działalność przemysłowa wpływa bezpośrednio na środowisko. Przykładem tego jest wpływ ujęć wód podziemnych na warunki hydrogeologiczne. Kluczowym elementem tego zagadnienia jest wybór optymalnej lokalizacji projektowanego ujęcia. Przedstawiany artykuł opisuje wielokryterialną ocenę różnych wariantów lokalizacji ujęcia wód podziemnych. Woda z projektowanego ujęcia będzie dostarczana do oczysz­czalni ścieków w Częstochowie do celów technologicznych. W celu zaprojektowania odpowiedniej studni głębinowej spełniającej określone wymagania przeprowadzono ob­liczenia analityczne m.in. promienia leja depresji i głębokości depresji, izochromy 25 lat oraz ustalono wytyczne dla projektu studni. Wykonano również wykres zwierciadła wód podziemnych podczas interakcji z ujęciem. Rezultatem wyżej wymienionych obliczeń było określenie zasięgu leja depresji oraz wybór wariantu budowy dwóch studni w ra­mach jednego ujęcia wód podziemnych. Dzięki wykonanej analizie zweryfikowano moż­liwości wspomagania procesu podejmowania szybkich i racjonalnych decyzji dla dużych obszarów, gdzie występuje wiele czynników wpływu na wydajność studni głębinowej.

PRZEBIEG SYMULACJI KOMPUTEROWEJ PROCESU OCZYSZCZANIA SCIEKÓW KOMUNALNYCH W REAKTORZE OSADU CZYNNEGO

OpenAIRE

Zbigniew KOWALEWSKI; Elena NEVEROVA-DZIOPAK

2016-01-01

Celem badań było ustalenie wpływu ilości i zakresu parametrów jakości ścieków surowych na wiarygodność wyników symulacji, co umożliwiłoby ustalenie optymalnej częstotliwości ich monitoringu, niezbędnego do pozyskiwania danych do modelowania w programach ASM. W artykule przedstawiono metodykę prowadzenia symulacji komputerowej procesu oczyszczania ścieków komunalnych w reaktorach biologicznych z osadem czynnym. Zaprezentowano sposób przygotowania i przetwarzania danych wejściowych do modelu or...

Measurements of the mass of the W boson in the W+W- → qq-barqq-bar channel with the ALEPH detector

International Nuclear Information System (INIS)

Chalmers, M.D.K.

1999-12-01

A measurement of the mass of the W boson from e + e - → W + W - → qq-barqq-bar events is presented, from LEP data collected at √s = 189 GeV during 1998 with the ALEPH detector. The procedure of direct reconstruction of the W + W - final state invariant mass distribution is adopted, with an optimisation of the event selection and jet clustering algorithms. A two dimensional Monte Carlo reweighting technique is used to extract the W mass and a full discussion of the systematic uncertainties is given. The W mass is measured to be: M W = 80.556 ± 0.110(stat.) ± 0.039(syst.) ± 0.056(F.S.I.) ± 0.017(LEP) GeV/c 2 . A new technique for extracting the W mass using a two dimensional Kolmogorov Smirnov test is introduced. The W mass using this method is measured to be: M W KS = 80.423 ± 0.160(expected stat.) GeV/c 2 , which is compared with that from the method of maximum likelihood. Rigorous optimisation and stability checks on the W mass estimator and its error are presented, and the result put into the context of a LEP and subsequently world average value: M W world = 80.394 ± 0.042 GeV/c 2 . The implications of this result are interpreted by comparing it with the indirect W mass measurement from the Standard Model prediction: M W indirect = 80.381 ± 0.026 GeV/c 2 . A discussion and outlook for the W mass measurement at LEP is given. (author)

Delayed myelosuppression with acute exposure to hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and environmental degradation product hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX) in rats

Energy Technology Data Exchange (ETDEWEB)

Jaligama, Sridhar; Kale, Vijay M.; Wilbanks, Mitchell S. [Department of Toxicology, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209 (United States); Perkins, Edward J. [US Army Engineer Research and Development Center, Vicksburg, MS 39180 (United States); Meyer, Sharon A., E-mail: meyer@ulm.edu [Department of Toxicology, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209 (United States)

2013-02-01

Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), a widely used munitions compound, and hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX), its N-nitroso product of anaerobic microbial nitroreduction, are contaminants of military sites. Previous studies have shown MNX to be the most acutely toxic among the nitroreduced degradation products of RDX and to cause mild anemia at high dose. The present study compares hematotoxicity with acute oral exposure to MNX with parent RDX. Both RDX and MNX caused a modest decrease in blood hemoglobin and ∼ 50% loss of granulocytes (NOAELs = 47 mg/kg) in female Sprague–Dawley rats observed 14 days post-exposure. We explored the possibility that blood cell loss observed after 14 days was delayed in onset because of toxicity to bone marrow (BM) progenitors. RDX and MNX decreased granulocyte/macrophage-colony forming cells (GM-CFCs) at 14, but not 7, days (NOAELs = 24 mg/kg). The earliest observed time at which MNX decreased GM-CFCs was 10 days post-exposure. RDX and MNX likewise decreased BM burst-forming units-erythroid (BFU-Es) at 14, but not 7, days. Granulocyte–erythrocyte–monocyte–megakaryocyte (GEMM)-CFCs were unaffected by RDX and MNX at 7 days suggesting precursor depletion did not account for GM-CFC and BFU-E loss. MNX added to the culture media was without effect on GM-CFC formation indicating no direct inhibition. Flow cytometry showed no differential loss of BM multilineage progenitors (Thy1.1{sup +}) or erythroid (CD71{sup +}) precursors with MNX suggesting myeloid and erythroid lineages were comparably affected. Collectively, these data indicate that acute exposure to both RDX and MNX caused delayed suppression of myelo- and erythropoiesis with subsequent decrease of peripheral granulocytes and erythrocytes. Highlights: ► Acute oral exposure to munitions RDX causes myelosuppression. ► Environmental degradation product MNX is comparable in effect. ► RDX and MNX are cytotoxic to both myeloid and erythroid

Zasób Flores Oratorii – norbertańskiej silvae rerum przechowywanej w Bibliotece Prowincjalnej Franciszkanów w Gnieźnie

Directory of Open Access Journals (Sweden)

Zbigniew Joskowski

2012-01-01

Full Text Available Artykuł prezentuje zasób norbertańskiej silvae rerum przechowywanej obecnie w dziale zbiorów specjalnych Biblioteki Prowincjalnej Franciszkanów w Gnieźnie (BPFG. Sylwa stanowi swoistą bibliotekę: zbiór odpisów mów, oracji dotyczących bieżącego życia politycznego XVIII wieku, dzieł poetyckich, życzeń, powinszowań okazjonalnych, a także twórczości własnej nieznanego zakonnika norbertańskiego – twórcy i właściciela sylwy.

Characteristic corporate culture of the Telkom way 135

Science.gov (United States)

Utami, D. A.; Noviyanti

2018-01-01

The corporate globalization brought an attention consequence related to the global perspective balancing against local flexibility. It also made local Organizations to keeps aware to both continuously and fast global changing and development in order to maintain its existences. One of the things need to be strengthened was the strong corporate culture, which is acceptable, understood and applied culture by every single member of the corporate. This study was aimed to describe characteristics of The Telkom Way 135 corporate culture and its implementation in PT. Telekomunikasi Indonesia Tbk., Regional Division V East Java. It was descriptive research with a qualitative approach and conducted it by observation, documentation, and documentation techniques. Data validity was conducted using credibility, transmittable, dependable and special criteria. Results of the study are as follows; the characteristic of The Telkom Way 135 corporate culture is an integral corporate culture. Also, by combination of this characteristic, corporate culture could classify into the strong and adaptive corporate culture so that it able to supports PT. Telkom to win the external adaptation and reached its internal integration if there is a harmonization between the corporate culture’s characteristics with the managerial practices.

Komórki Th17 w patogenezie reumatoidalnego zapalenia stawów

Directory of Open Access Journals (Sweden)

Agnieszka Paradowska-Gorycka

2010-10-01

Full Text Available Dzikie komórki CD4+, stymulowane przez komórki prezentująceantygen (APCs i szereg cytokin, ulegają aktywacji i różnicowaniudo wielu subpopulacji limfocytów pomocniczych (Th odgrywającychgłówną rolę w modulowaniu odpowiedzi układu immunologicznego.Komórki Th1 i Th2 uczestniczą w regulacji odpowiedzikomórkowej i humoralnej, komórki Th17 zostały zaś zidentyfikowanejako subpopulacja komórek Th regulujących procesy zapalnepoprzez produkcję odrębnych cytokin, takich jak IL-17. Głównącechą tej subpopulacji komórek jest udział w odpowiedzi skierowanejprzeciwko drobnoustrojom oraz w patogenezie choróbautoimmunologicznych i alergicznych. Znaczenie komórek Th17oraz IL-17 w regulacji poszczególnych etapów procesu zapalnegotoczącego się w reumatoidalnym stawie nadal nie jest w pełnipoznane i stanowi ostatnio cel wielu badań. W prezentowanej pracyomówiono najnowsze doniesienia dotyczące fenotypu, różnicowaniaoraz najważniejszych funkcji biologicznych ludzkich komórekTh17, a także przedstawiono ich rolę w patogeneziereumatoidalnego zapalenia stawów.

42 CFR 435.135 - Individuals who become ineligible for cash assistance as a result of OASDI cost-of-living...

Science.gov (United States)

2010-10-01

... 42 Public Health 4 2010-10-01 2010-10-01 false Individuals who become ineligible for cash assistance as a result of OASDI cost-of-living increases received after April 1977. 435.135 Section 435.135..., Blind, and Disabled § 435.135 Individuals who become ineligible for cash assistance as a result of OASDI...

Certolizumab pegol w leczeniu reumatoidalnego zapalenia stawów

Directory of Open Access Journals (Sweden)

Piotr Wiland

2011-08-01

Full Text Available Wostatnich latach wyprodukowano i oceniono w wielu badaniachlaboratoryjnych i klinicznych nowy lek hamujący funkcje biologiczneczynnika martwicy nowotworu (tumour necrosis factor – TNF –certolizumab pegol. Dzięki pegylacji (dołączeniu do fragmentuFab przeciwciała neutralizującego TNF cząsteczki glikolu polietylenowegozwiązek ten wykazuje nieco odmienne właściwościw porównaniu z innymi lekami blokującymi TNF. W artykule przedstawionopodobieństwa i różnice mechanizmów działania, farmakokinetyki,metabolizmu, skuteczności klinicznej, wpływu na progresjęradiologiczną i bezpieczeństwa stosowania certolizumabuw porównaniu z innymi lekami biologicznymi hamującymi funkcjebiologiczne TNF w leczeniu chorych na reumatoidalne zapaleniestawów (tab. I–III. Badania kliniczne wykazały bardzo szybkąodpowiedź kliniczną na zastosowany certolizumab (tab. II, ryc. 1.Dodatkowo można z dużym prawdopodobieństwem przewidziećdługoterminową skuteczność tego leku, co może mieć istotnywpływ na farmakoekonomikę leczenia.

21 CFR 1404.135 - May the Office of National Drug Control Policy exclude a person who is not currently...

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 9 2010-04-01 2010-04-01 false May the Office of National Drug Control Policy exclude a person who is not currently participating in a nonprocurement transaction? 1404.135 Section 1404.135 Food and Drugs OFFICE OF NATIONAL DRUG CONTROL POLICY GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1404.135 May the...

Estandarización de ensayos inmunoenzimáticos (ELISA para la cuantificación de anticuerpos IgG inducidos por una vacuna de vesículas de membrana externa de los serogrupos A y W135 de Neisseria meningitidis

Directory of Open Access Journals (Sweden)

Aleida Mandiarote

2013-04-01

Full Text Available La enfermedad meningocócica es una afección invasiva, de amplia incidencia mundial, cuyo agente causal es la bacteria gramnegativa Neisseria meningitidis . Existen vacunas polisacarídicas sin conjugar o conjugadas, contra cuatro de los cinco serogrupos responsables del 95% de los casos en el mundo. Para el serogrupo B, cuyo polisacárido es pobremente inmunogénico, se han evaluado varios candidatos vacunales producidos a base de vesículas de membrana externa. La determinación de la actividad bactericida y la cuantificación de IgG por ELISA han sido los métodos más utilizados en la medición de la respuesta inmune generada por vacunas contra la meningitis meningocócica. El segundo de estos métodos es utilizado en el Instituto Finlay como ensayo de inmunogenicidad para la liberación de lotes de VA-MENGOC-BC®. Como parte de una colaboración con investigadores noruegos, se trabaja en la obtención de un candidato vacunal contra los serogrupos A y W135 , basado en vesículas de membrana externa. En el presente trabajo se describe la estandarización de un ELISA para ser utilizado en la evaluación de la respuesta inmune del candidato vacunal bivalente.

Electron shuttle-mediated biotransformation of hexahydro-1,3,5-trinitro-1,3,5-triazine adsorbed to granular activated carbon.

Science.gov (United States)

Millerick, Kayleigh; Drew, Scott R; Finneran, Kevin T

2013-08-06

Granular activated carbon (GAC) effectively removes hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) from groundwater but generates RDX-laden GAC that must be disposed of or regenerated. Batch reactors containing GAC to which RDX was preadsorbed were used in experiments to test the potential for adsorbed RDX reduction and daughter product formation using (i) chemically reduced anthrahydroquinone-2,6-disulfonate (AH2QDS), (ii) resting Geobacter metallireducens strain GS-15, and (iii) a combined system containing AQDS and GS-15. Approximately 97.0% of the adsorbed RDX was transformed in each of these experimental systems by 90 h. Chemically reduced AQDS (AH2QDS) transformed 99.2% of adsorbed RDX; formaldehyde was produced rapidly and was stoichiometric (3 mol HCHO per mol RDX). Geobacter metallireducens also reduced RDX with and without AQDS present. This is the first study to demonstrate biological transformation of RDX adsorbed to GAC. Formaldehyde increased and then decreased in biological systems, suggesting a previously unreported capacity for G. metallireducens to oxidize formaldehyde, which was confirmed with resting cell suspensions. These data suggest the masses of GAC waste currently produced by activated carbon at RDX remediation sites can be minimized, decreasing the carbon footprint of the treatment technology. Alternatively, this strategy may be used to develop a Bio-GAC system for ex situ RDX treatment.

High thermal stability in W/MgO/CoFeB/W/CoFeB/W stacks via ultrathin W insertion with perpendicular magnetic anisotropy

Energy Technology Data Exchange (ETDEWEB)

Liu, Yi; Yu, Tao [School of Physics and Nuclear Energy Engineering, Beihang University, Beijing 100191 (China); Zhu, Zhengyong; Zhong, Huicai [Institute of Microelectronics, Chinese Academy of Sciences, Beijing 100029 (China); Khamis, Khamis Masoud [School of Physics and Nuclear Energy Engineering, Beihang University, Beijing 100191 (China); Zhu, Kaigui, E-mail: kgzhu@buaa.edu.cn [School of Physics and Nuclear Energy Engineering, Beihang University, Beijing 100191 (China); Key Laboratory of Micro-Nano Measurement-Manipulation and Physics, Ministry of Education, Beihang University, Beijing 100191 (China)

2016-07-15

The perpendicular magnetic anisotropy (PMA) of a series of top MgO/CoFeB/W stacks were studied. In these stacks, the thickness of CoFeB is limited in a range of 1.1–2.2 nm. It was found that the stack can still maintain PMA in a 1.9 nm thick CoFeB free layer. Besides, we investigated the thermal stability factor ∆ of a spin transfer torque magnetic random access memory (STT-MRAM) by inserting an ultra-thin W film of 0.8 nm between two CoFeB films. The result shows a clear PMA behavior for the samples with CoFeB thickness up to 2.5 nm, and an in-plane magnetic anisotropy (IMA) when the CoFeB is thicker than 2.5 nm. Moreover, the thermal stability factor ∆ of the CoFeB stack with W insertion is about 132 for a 50 nm size STT-MRAM device, which is remarkably improved compared to 112 for a sample without W insertion. Our results represent an alternative way to realize the endurance at high annealing temperature, high-density and high ∆ in STT-MRAM device by ultra-thin W insertion. - Highlights: • The MgO/CoFeB/W multilayer can still maintain PMA in a CoFeB thickness of 1.9 nm. • The sample with 2.5 nm thickness of CoFeB by W insertion can still maintain PMA. • The sample with W insertion can still maintain PMA until the annealing temperature as high as 350 °C. • The thermal stability factor ∆ of sample with W insertion could be increase to about 132 for a 50 nm size STT-MRAM device.

The combined SPE:ToxY-PAM phytotoxicity assay; application and appraisal of a novel biomonitoring tool for the aquatic environment.

Science.gov (United States)

Bengtson Nash, S M; Schreiber, U; Ralph, P J; Müller, J F

2005-01-15

Mounting concerns regarding the environmental impact of herbicides has meant a growing requirement for accurate, timely information regarding herbicide residue contamination of, in particular, aquatic systems. Conventional methods of detection remain limited in terms of practicality due to high costs of operation and the specialised information that analysis provides. A new phytotoxicity bioassay was trialled for the detection of herbicide residues in filter-purified (Milli-Q) as well as natural waters. The performance of the system, which combines solid-phase extraction (SPE) with the ToxY-PAM dual-channel yield analyser (Heinz Walz GmbH), was tested alongside the traditional method of liquid chromatography-mass spectrometry (LC-MS). The assay methodology was found to be highly sensitive (LOD 0.1 ng L(-1) diuron) with good reproducibility. The study showed that the assay protocol is time effective and can be employed for the aquatic screening of herbicide residues in purified as well as natural waters.

Measurement of the w boson mass and $w^{+} w^{-}$ production and decay properties in $e^{+}e^{-}$ collisions at s**(1/2) = 172-GeV

CERN Document Server

Ackerstaff, K.; Allison, John; Altekamp, N.; Anderson, K.J.; Anderson, S.; Arcelli, S.; Asai, S.; Axen, D.; Azuelos, G.; Ball, A.H.; Barberio, E.; Barlow, Roger J.; Bartoldus, R.; Batley, J.R.; Baumann, S.; Bechtluft, J.; Beeston, C.; Behnke, T.; Bell, A.N.; Bell, Kenneth Watson; Bella, G.; Bentvelsen, S.; Bethke, S.; Biebel, O.; Biguzzi, A.; Bird, S.D.; Blobel, V.; Bloodworth, I.J.; Bloomer, J.E.; Bobinski, M.; Bock, P.; Bonacorsi, D.; Boutemeur, M.; Bouwens, B.T.; Braibant, S.; Brigliadori, L.; Brown, Robert M.; Burckhart, H.J.; Burgard, C.; Burgin, R.; Capiluppi, P.; Carnegie, R.K.; Carter, A.A.; Carter, J.R.; Chang, C.Y.; Charlton, David G.; Chrisman, D.; Clarke, P.E.L.; Cohen, I.; Conboy, J.E.; Cooke, O.C.; Cuffiani, M.; Dado, S.; Dallapiccola, C.; Dallavalle, G.Marco; Davies, R.; De Jong, S.; del Pozo, L.A.; Desch, K.; Dienes, B.; Dixit, M.S.; do Couto e Silva, E.; Doucet, M.; Duchovni, E.; Duckeck, G.; Duerdoth, I.P.; Eatough, D.; Edwards, J.E.G.; Estabrooks, P.G.; Evans, H.G.; Evans, M.; Fabbri, F.; Fanti, M.; Faust, A.A.; Fiedler, F.; Fierro, M.; Fischer, H.M.; Fleck, I.; Folman, R.; Fong, D.G.; Foucher, M.; Furtjes, A.; Futyan, D.I.; Gagnon, P.; Gary, J.W.; Gascon, J.; Gascon-Shotkin, S.M.; Geddes, N.I.; Geich-Gimbel, C.; Geralis, T.; Giacomelli, G.; Giacomelli, P.; Giacomelli, R.; Gibson, V.; Gibson, W.R.; Gingrich, D.M.; Glenzinski, D.; Goldberg, J.; Goodrick, M.J.; Gorn, W.; Grandi, C.; Gross, E.; Grunhaus, J.; Gruwe, M.; Hajdu, C.; Hanson, G.G.; Hansroul, M.; Hapke, M.; Hargrove, C.K.; Hart, P.A.; Hartmann, C.; Hauschild, M.; Hawkes, C.M.; Hawkings, R.; Hemingway, R.J.; Herndon, M.; Herten, G.; Heuer, R.D.; Hildreth, M.D.; Hill, J.C.; Hillier, S.J.; Hobson, P.R.; Homer, R.J.; Honma, A.K.; Horvath, D.; Hossain, K.R.; Howard, R.; Huntemeyer, P.; Hutchcroft, D.E.; Igo-Kemenes, P.; Imrie, D.C.; Ingram, M.R.; Ishii, K.; Jawahery, A.; Jeffreys, P.W.; Jeremie, H.; Jimack, M.; Joly, A.; Jones, C.R.; Jones, G.; Jones, M.; Jost, U.; Jovanovic, P.; Junk, T.R.; Karlen, D.; Kartvelishvili, V.; Kawagoe, K.; Kawamoto, T.; Kayal, P.I.; Keeler, R.K.; Kellogg, R.G.; Kennedy, B.W.; Kirk, J.; Klier, A.; Kluth, S.; Kobayashi, T.; Kobel, M.; Koetke, D.S.; Kokott, T.P.; Kolrep, M.; Komamiya, S.; Kress, T.; Krieger, P.; von Krogh, J.; Kyberd, P.; Lafferty, G.D.; Lahmann, R.; Lai, W.P.; Lanske, D.; Lauber, J.; Lautenschlager, S.R.; Layter, J.G.; Lazic, D.; Lee, A.M.; Lefebvre, E.; Lellouch, D.; Letts, J.; Levinson, L.; Lloyd, S.L.; Loebinger, F.K.; Long, G.D.; Losty, M.J.; Ludwig, J.; Macchiolo, A.; Macpherson, A.; Mannelli, M.; Marcellini, S.; Markus, C.; Martin, A.J.; Martin, J.P.; Martinez, G.; Mashimo, T.; Mattig, Peter; McDonald, W.John; McKenna, J.; Mckigney, E.A.; McMahon, T.J.; McPherson, R.A.; Meijers, F.; Menke, S.; Merritt, F.S.; Mes, H.; Meyer, J.; Michelini, A.; Mikenberg, G.; Miller, D.J.; Mincer, A.; Mir, R.; Mohr, W.; Montanari, A.; Mori, T.; Morii, M.; Muller, U.; Mihara, S.; Nagai, K.; Nakamura, I.; Neal, H.A.; Nellen, B.; Nisius, R.; O'Neale, S.W.; Oakham, F.G.; Odorici, F.; Ogren, H.O.; Oh, A.; Oldershaw, N.J.; Oreglia, M.J.; Orito, S.; Palinkas, J.; Pasztor, G.; Pater, J.R.; Patrick, G.N.; Patt, J.; Pearce, M.J.; Perez-Ochoa, R.; Petzold, S.; Pfeifenschneider, P.; Pilcher, J.E.; Pinfold, J.; Plane, David E.; Poffenberger, P.; Poli, B.; Posthaus, A.; Rees, D.L.; Rigby, D.; Robertson, S.; Robins, S.A.; Rodning, N.; Roney, J.M.; Rooke, A.; Ros, E.; Rossi, A.M.; Routenburg, P.; Rozen, Y.; Runge, K.; Runolfsson, O.; Ruppel, U.; Rust, D.R.; Rylko, R.; Sachs, K.; Saeki, T.; Sarkisian, E.K.G.; Sbarra, C.; Schaile, A.D.; Schaile, O.; Scharf, F.; Scharff-Hansen, P.; Schenk, P.; Schieck, J.; Schleper, P.; Schmitt, B.; Schmitt, S.; Schoning, A.; Schroder, Matthias; Schultz-Coulon, H.C.; Schumacher, M.; Schwick, C.; Scott, W.G.; Shears, T.G.; Shen, B.C.; Shepherd-Themistocleous, C.H.; Sherwood, P.; Siroli, G.P.; Sittler, A.; Skillman, A.; Skuja, A.; Smith, A.M.; Snow, G.A.; Sobie, R.; Soldner-Rembold, S.; Springer, Robert Wayne; Sproston, M.; Stephens, K.; Steuerer, J.; Stockhausen, B.; Stoll, K.; Strom, David M.; Szymanski, P.; Tafirout, R.; Talbot, S.D.; Tanaka, S.; Taras, P.; Tarem, S.; Teuscher, R.; Thiergen, M.; Thomson, M.A.; von Torne, E.; Towers, S.; Trigger, I.; Trocsanyi, Z.; Tsur, E.; Turcot, A.S.; Turner-Watson, M.F.; Utzat, P.; Van Kooten, Rick J.; Verzocchi, M.; Vikas, P.; Vokurka, E.H.; Voss, H.; Wackerle, F.; Wagner, A.; Ward, C.P.; Ward, D.R.; Watkins, P.M.; Watson, A.T.; Watson, N.K.; Wells, P.S.; Wermes, N.; White, J.S.; Wilkens, B.; Wilson, G.W.; Wilson, J.A.; Wolf, G.; Wyatt, T.R.; Yamashita, S.; Yekutieli, G.; Zacek, V.; Zer-Zion, D.

1998-01-01

This paper describes the measurement of the W boson mass, M_W, and decay width, Gamma_W, from the direct reconstruction of the invariant mass of its decay products in W pair events collected at a mean centre-of-mass energy of sqrt{s} = 172.12 GeV with the OPAL detector at LEP. Measurements of the W pair production cross-section, the W decay branching fractions and properties of the W decay final states are also described. A total of 120 candidate W^+W^- events has been selected for an integrated luminosity of 10.36 pb^-1. The W^+W^- production cross-section is measured to be sigma_WW = 12.3 +/- 1.3(stat.) +/- 0.3(syst.) pb, consistent with the Standard Model expectation. The W^+W^- -> qq(bar) l nu and W^+W^- -> qq(bar)qq(bar) final states are used to obtain a direct measurement of Gamma_W = 1.30^{+0.62}_{-0.55}(stat.) +/- 0.18(syst.) GeV. Assuming the Standard Model relation between M_W and Gamma_W, the W boson mass is measured to be M_W = 80.32 +/- 0.30(stat.) +/- 0.09(syst.) GeV. The event properties of the...

Recommendation on changing interfaces of W-058 and W-236A

International Nuclear Information System (INIS)

Light, J.M.

1994-01-01

This position paper recommends changes to improve the interface between the Cross-Site Transfer System (Project W-058) and the Multi-Function Waste Tank Facility (Project W-236A) to handle planned waste retrieval and storage operations. Appendix A includes cost estimates and schedule impacts for each project. The cost estimates, schedule impacts, and this position paper will be the basis for writing a change request to formally implement these changes on Project W-236A and Project W-058/W-028. Recommendations are made on pipeline rerouting, pump and configuration, and flushing configuration

Pozarolnicza działalność gospodarcza w gminie Uniejów

OpenAIRE

Kowalski, Michał

2015-01-01

Przedmiotem niniejszego artykułu jest struktura i potencjał gospodarczy pozarolniczej działalności w gminie Uniejów. Struktura gospodarcza została zaprezentowana w ujęciu przestrzennym w relacji miasto–wieś oraz gmina Uniejów–małe miasta regionu. W opracowaniu ukazany zostanie lokalny krajobraz gospodarczy i zachodzące w nim relacje. Analizę przeprowadzono przy wykorzystaniu lokalnej historii gospodarczej, oficjalnych danych statystycznych dotyczących liczby przedsiębiorstw prowadzących dział...

14 CFR 119.71 - Management personnel: Qualifications for operations conducted under part 135 of this chapter.

Science.gov (United States)

2010-01-01

... or Part 135 of This Chapter § 119.71 Management personnel: Qualifications for operations conducted... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Management personnel: Qualifications for operations conducted under part 135 of this chapter. 119.71 Section 119.71 Aeronautics and Space FEDERAL...

Orestes bojownikiem ruchu oporu, czyli mit Atrydów w filmie "Podróż komediantów" Theo Angelopoulosa

Directory of Open Access Journals (Sweden)

Iga Łomanowska

2016-12-01

Full Text Available Orestes as a resistance fighter, or the myth of the Atreides in Theo Angelopoulos’s film The travelling players The paper examines the use of the Atreides myth in Theo Angelopoulos’s film The travelling players (1975 in the context of the director’s interpretation of the phenomenon of myth. Angelopoulos treated myth as a set of archetypical situations and patterns of conduct constantly reproduced in the history of the world. He intertwined elements of classical stories with the history of Greece and the Byzantine tradition, thus showing their universal character. In The travelling players, Angelopoulos used the story of betrayed and murdered Agamemnon, who is avenged by his children: Orestes and Electra, but he moved it into modern times, setting the film in Greece of the 1940s and 1950s. The myth is reproduced with modulations: the most important events take place as a result of interventions of History, not fate or decisions of the gods. Moreover, the characters’ conflicts are enriched with a political dimension, as Angelopolous portrays the discord between their ideological stances. But the members of the acting company are as helpless in the face of events as the family of the king of Argos.   Orestes bojownikiem ruchu oporu, czyli mit Atrydów w filmie Podróż komediantów Theo Angelopoulosa Artykuł jest analizą sposobu wykorzystania przez Theo Angelopoulosa mitu Atrydów w filmie Podróż komediantów (1975 w kontekście dokonanej przez niego interpretacji zjawiska mitu. Grecki reżyser traktował mit jako zbiór archetypicznych sytuacji i wzorów postępowania odtwarzanych nieustannie w dziejach świata. Elementy antycznych opowieści splatał w filmach z historią Grecji i tradycją bizantyjską, ujawniając ich uniwersalny charakter. W Podróży komediantów wykorzystał historię zdradzonego i zamordowanego Agamemnona, który zostaje pomszczony przez swoje dzieci: Orestesa i Elektrę, ale przeniósł ją w czasy wsp

Ćwiczenia z narastającym oporem w usprawnianiu pacjentów z reumatoidalnym zapaleniem stawów leczonych operacyjnie

Directory of Open Access Journals (Sweden)

Agnieszka Prusinowska

2010-08-01

Full Text Available W artykule przedstawiono formę ćwiczeń czynnych oporowychwykorzystywanych do usprawniania pacjentów z rozpoznaniemreumatoidalnego zapalenia stawów po typowych zabiegach ortopedycznychw obrębie narządu ruchu. Forma ćwiczeń umożliwiausprawnianie pacjenta zarówno w warunkach klinicznych, jaki domowych. Jest atrakcyjna dla pacjenta, nie wymaga zakupu drogiegoi często skomplikowanego w obsłudze sprzętu.

Clinical significance of combined detection of multiple serum antibodies (AsAb, EmAb, AcAb, AoAb, ToxAb) in infertile women

International Nuclear Information System (INIS)

Chen Jing; Jiang Li; Lu Ya

2005-01-01

Objective: To determine the clinical significance of combined detection of multiple serum antibodies in infertile women. Methods; Serum multiple antibodies were examined in 120 infertile women, including 88 failed to get pregnancy and 32 with repeated spontaneous abortion. The antibodies tested were: (1) anti-sperm antibody (AsAb) (2) endometrial antibody (EmAb) (3) anti-cardiophospholipid antibody (AcAb) (4) Anti-ovarian antibody (AoAb) and Toxoplasmosis antibody (ToxAb). Results: In 48 of the infertile women, none of the five antibodies were positive (40% of 120). The rest were: one antibody positive--38/120 or 31.6%; two antibodies positive--31/120 or 25.83%, three and four antibodies positive--4/120 or 3.33%. None of the women were positive with all five antibodies. Conclusion: Immune factor was the chief cause of infertility in women. (authors)

Testing of chemicals for genetic activity with Saccharomyces cerevisiae: a report of the U. S. Environmental Protection Agency Gene-Tox Program

Energy Technology Data Exchange (ETDEWEB)

Zimmermann, F.K.; von Borstel, R.C.; von Halle, E.S.; Parry, J.M.; Siebert, D.; Zetterberg, G.; Barale, R.; Loprieno, N.

1984-01-01

This review article with over 200 references summarizes the results of mutation screening tests with 492 chemicals using saccharomyces cerevisiae as the test organism. In addition, an extensive description of S. cerevisiae as a test organism is given. Yeast can be used to study genetic effects both in mitotic and in meiotic cells because it can be cultured as a stable haploid or a stable diploid. The most commonly used genetic endpoint has been mitotic recombination either as mitotic crossing-over or mitotic gene conversion. Data were available on tests with 492 chemicals, of which 249 were positive, as reported in 173 articles or reports. The genetic test/carcinogenicity accuracy was 0.74, based on the carcinogen listing established in the gene-tox program. The yeast tests supplement the bacterial tests for detecting agents that act via radical formation, antibacterial drugs, and other chemicals interfering with chromosome segregation and recombination processes.

Wiek startu szkolnego a osiągnięcia w nauce w okresie wczesnoszkolnym

Directory of Open Access Journals (Sweden)

Krzysztof Konarzewski

2013-12-01

Full Text Available W celu oszacowania związku między osiągnięciami szkolnymi a względnym i bezwzględnym wiekiem uczniów poddano analizie dane 101 519 średnio dziesięcioletnich uczniów z 5585 oddziałów 25 krajów Europy biorących udział w międzynarodowym pomiarze osiągnięć szkolnych IEA TIMSS 2011. W hierarchicznej analizie regresji zmienną zależną były osiągnięcia w matematyce i przyrodoznawstwie, a zmiennymi niezależnymi – względny wiek ucznia w oddziale klasowym i średni wiek oddziału. Efekt względnego wieku okazał się silniejszy niż w badaniach ignorujących podział uczniów na oddziały, mimo że najstarsi i najmłodsi w oddziale urodzili się w różnych porach roku. Efekt względnego wieku zależał od średniej wieku w oddziale: w oddziałach najmłodszych był najsilniejszy, a w najstarszych – nieodróżnialny od zera. Średnia osiągnięć (zwłaszcza w przyrodoznawstwie była wyższa w oddziałach starszych niż w młodszych.

Toxicity of hexahydro-1,3,5-trinitro-1,3,5-triazine to larval zebrafish (Danio rerio)

Science.gov (United States)

Mukhi, S.; Pan, X.; Cobb, G.P.; Patino, R.

2005-01-01

Hexahydro-1,3,5-trinitro-1,3,5-triazine, a cyclonitramine commonly known as RDX, is used in the production of military munitions. Contamination of soil, sediment, and ground and surface waters with RDX has been reported in different places around the world. Acute and subacute toxicities of RDX have been relatively well documented in terrestrial vertebrates, but among aquatic vertebrates the information available is limited. The objective of this study was to characterize the acute toxicity of RDX to larval zebrafish. Mortality (LC50) and incidence of vertebral column deformities (EC50) were two of the end points measured in this study. The 96-h LC50 was estimated at 22.98 and 25.64 mg l-1 in two different tests. The estimated no-observed-effective- concentration (NOEC) values of RDX on lethality were 13.27 ?? 0.05 and 15.32 ?? 0.30 mg l-1; and the lowest-observed-effective- concentration (LOEC) values were 16.52 ?? 0.05 and 19.09 ?? 0.23 mg l-1 in these two tests, respectively. The 96-h EC50 for vertebral deformities on survivors from one of the acute lethality tests was estimated at 20.84 mg l-1, with NOEC and LOEC of 9.75 ?? 0.34 and 12.84 ?? 0.34 mg l-1, respectively. Behavioral aberrations were also noted in this acute toxicity study, including the occurrence of whirling movement and lethargic behavior. The acute effects of RDX on survival, incidence of deformities, and behavior of larval zebrafish occurred at the high end of the most frequently reported concentrations of RDX in aquatic environments. The chronic effects of RDX in aquatic vertebrates need to be determined for an adequate assessment of the ecological risk of environmental RDX. ?? 2005 Elsevier Ltd. All rights reserved.

24 CFR 100.135 - Unlawful practices in the selling, brokering, or appraising of residential real property.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Unlawful practices in the selling, brokering, or appraising of residential real property. 100.135 Section 100.135 Housing and Urban Development... residential real property in connection with the sale, rental, or financing of any dwelling where the person...

Zastosowanie programów komputerowych w rehabilitacji neuropsychologicznej dysfunkcji poznawczych u pacjentów ze stwardnieniem rozsianym

Directory of Open Access Journals (Sweden)

Ernest Tyburski

2013-06-01

Full Text Available W obrazie klinicznym stwardnienia rozsianego (łac. sclerosis multiplex, SM na funkcjonowanie chorych wpływają – poza objawami neurologicznymi – współwystępujące objawy neuropsychologiczne, do których zalicza się zaburzenia emocjonalne i dysfunkcje poznawcze oraz czynniki osobowościowe. Dysfunkcje w sferze procesów uwagi, funkcji wykonawczych czy pamięci mają wpływ na zmniejszenie zdolności adaptacyjnych, które są kluczowe dla jakości życia chorych. W badaniach dużych grup klinicznych udowodniono obecność dysfunkcji poznawczych u 40–65% pacjentów. Najczęściej na SM zapadają osoby młode, u których dysfunkcje ruchowe i zaburzenia poznawcze mogą utrudniać codzienne funkcjonowanie, a często też stają się przeszkodą w podejmowaniu zadań życiowych. Dlatego też istnieje potrzeba opracowania nowych i skutecznych programów rehabilitacyjnych dla tej grupy chorych. Rehabilitacja neuropsychologiczna pacjentów z SM obejmuje różnego rodzaju oddziaływania, których celem jest leczenie dysfunkcji poznawczych. W pracy neuropsychologa coraz częściej jako narzędzie terapeutyczne wykorzystuje się programy komputerowe służące do treningów poznawczych. Podstawą dla tego typu oddziaływań są dowody świadczące o zmianach neuroplastycznych u osób ze stwardnieniem rozsianym. Największe efekty terapeutyczne osiąga się jednak dzięki współpracy zespołu interdyscyplinarnego, w którego skład powinni wchodzić neurolog, psychiatra, neuropsycholog oraz rehabilitant. W Polsce uzyskanie takiej pomocy przez pacjentów z SM jest nadal bardzo trudne. Przykładem obrazującym skuteczne zastosowanie rehabilitacji neuropsychologicznej za pomocą programów komputerowych jest studium przypadku chorego ze stwardnieniem rozsianym.

$W^{+}W^{-}$ Production Cross Section and W Branching Fractions in $e^{+}e^{-}$ Collisions at 189 GeV

CERN Document Server

Abbiendi, G.; Ainsley, C.; Akesson, P.F.; Alexander, G.; Allison, John; Anderson, K.J.; Arcelli, S.; Asai, S.; Ashby, S.F.; Axen, D.; Azuelos, G.; Bailey, I.; Ball, A.H.; Barberio, E.; Barlow, Roger J.; Baumann, S.; Behnke, T.; Bell, Kenneth Watson; Bella, G.; Bellerive, A.; Benelli, G.; Bentvelsen, S.; Bethke, S.; Biebel, O.; Bloodworth, I.J.; Boeriu, O.; Bock, P.; Bohme, J.; Bonacorsi, D.; Boutemeur, M.; Braibant, S.; Bright-Thomas, P.; Brigliadori, L.; Brown, Robert M.; Burckhart, H.J.; Cammin, J.; Capiluppi, P.; Carnegie, R.K.; Carter, A.A.; Carter, J.R.; Chang, C.Y.; Charlton, David G.; Clarke, P.E.L.; Clay, E.; Cohen, I.; Cooke, O.C.; Couchman, J.; Couyoumtzelis, C.; Coxe, R.L.; Csilling, A.; Cuffiani, M.; Dado, S.; Dallavalle, G.Marco; Dallison, S.; de Roeck, A.; de Wolf, E.; Dervan, P.; Desch, K.; Dienes, B.; Dixit, M.S.; Donkers, M.; Dubbert, J.; Duchovni, E.; Duckeck, G.; Duerdoth, I.P.; Estabrooks, P.G.; Etzion, E.; Fabbri, F.; Fanti, M.; Feld, L.; Ferrari, P.; Fiedler, F.; Fleck, I.; Ford, M.; Frey, A.; Furtjes, A.; Futyan, D.I.; Gagnon, P.; Gary, J.W.; Gaycken, G.; Geich-Gimbel, C.; Giacomelli, G.; Giacomelli, P.; Glenzinski, D.; Goldberg, J.; Grandi, C.; Graham, K.; Gross, E.; Grunhaus, J.; Gruwe, M.; Gunther, P.O.; Hajdu, C.; Hanson, G.G.; Hansroul, M.; Hapke, M.; Harder, K.; Harel, A.; Harin-Dirac, M.; Hauke, A.; Hauschild, M.; Hawkes, C.M.; Hawkings, R.; Hemingway, R.J.; Hensel, C.; Herten, G.; Heuer, R.D.; Hill, J.C.; Hocker, James Andrew; Hoffman, Kara Dion; Homer, R.J.; Honma, A.K.; Horvath, D.; Hossain, K.R.; Howard, R.; Huntemeyer, P.; Igo-Kemenes, P.; Ishii, K.; Jacob, F.R.; Jawahery, A.; Jeremie, H.; Jones, C.R.; Jovanovic, P.; Junk, T.R.; Kanaya, N.; Kanzaki, J.; Karapetian, G.; Karlen, D.; Kartvelishvili, V.; Kawagoe, K.; Kawamoto, T.; Keeler, R.K.; Kellogg, R.G.; Kennedy, B.W.; Kim, D.H.; Klein, K.; Klier, A.; Kluth, S.; Kobayashi, T.; Kobel, M.; Kokott, T.P.; Komamiya, S.; Kowalewski, Robert V.; Kress, T.; Krieger, P.; von Krogh, J.; Kuhl, T.; Kupper, M.; Kyberd, P.; Lafferty, G.D.; Landsman, H.; Lanske, D.; Lawson, I.; Layter, J.G.; Leins, A.; Lellouch, D.; Letts, J.; Levinson, L.; Liebisch, R.; Lillich, J.; List, B.; Littlewood, C.; Lloyd, A.W.; Lloyd, S.L.; Loebinger, F.K.; Long, G.D.; Losty, M.J.; Lu, J.; Ludwig, J.; Macchiolo, A.; Macpherson, A.; Mader, W.; Marcellini, S.; Marchant, T.E.; Martin, A.J.; Martin, J.P.; Martinez, G.; Mashimo, T.; Mattig, Peter; McDonald, W.John; McKenna, J.; McMahon, T.J.; McPherson, R.A.; Meijers, F.; Mendez-Lorenzo, P.; Menges, W.; Merritt, F.S.; Mes, H.; Michelini, A.; Mihara, S.; Mikenberg, G.; Miller, D.J.; Mohr, W.; Montanari, A.; Mori, T.; Nagai, K.; Nakamura, I.; Neal, H.A.; Nisius, R.; O'Neale, S.W.; Oakham, F.G.; Odorici, F.; Ogren, H.O.; Oh, A.; Okpara, A.; Oreglia, M.J.; Orito, S.; Pasztor, G.; Pater, J.R.; Patrick, G.N.; Patt, J.; Pfeifenschneider, P.; Pilcher, J.E.; Pinfold, J.; Plane, David E.; Poli, B.; Polok, J.; Pooth, O.; Przybycien, M.; Quadt, A.; Rembser, C.; Renkel, P.; Rick, H.; Rodning, N.; Roney, J.M.; Rosati, S.; Roscoe, K.; Rossi, A.M.; Rozen, Y.; Runge, K.; Runolfsson, O.; Rust, D.R.; Sachs, K.; Saeki, T.; Sahr, O.; Sarkisyan, E.K.G.; Sbarra, C.; Schaile, A.D.; Schaile, O.; Scharff-Hansen, P.; Schroder, Matthias; Schumacher, M.; Schwick, C.; Scott, W.G.; Seuster, R.; Shears, T.G.; Shen, B.C.; Shepherd-Themistocleous, C.H.; Sherwood, P.; Siroli, G.P.; Skuja, A.; Smith, A.M.; Snow, G.A.; Sobie, R.; Soldner-Rembold, S.; Spagnolo, S.; Sproston, M.; Stahl, A.; Stephens, K.; Stoll, K.; Strom, David M.; Strohmer, R.; Stumpf, L.; Surrow, B.; Talbot, S.D.; Tarem, S.; Taylor, R.J.; Teuscher, R.; Thiergen, M.; Thomas, J.; Thomson, M.A.; Torrence, E.; Towers, S.; Toya, D.; Trefzger, T.; Trigger, I.; Trocsanyi, Z.; Tsur, E.; Turner-Watson, M.F.; Ueda, I.; Vachon, B.; Vannerem, P.; Verzocchi, M.; Voss, H.; Vossebeld, J.; Waller, D.; Ward, C.P.; Ward, D.R.; Watkins, P.M.; Watson, A.T.; Watson, N.K.; Wells, P.S.; Wengler, T.; Wermes, N.; Wetterling, D.; White, J.S.; Wilson, G.W.; Wilson, J.A.; Wyatt, T.R.; Yamashita, S.; Zacek, V.; Zer-Zion, D.

2000-01-01

From a data sample of 183 pb^-1 recorded at a center-of-mass energy of roots = 189 GeV with the OPAL detector at LEP, 3068 W-pair candidate events are selected. Assuming Standard Model W boson decay branching fractions, the W-pair production cross section is measured to be sigmaWW = 16.30 +- 0.34(stat.) +- 0.18(syst.) pb. When combined with previous OPAL measurements, the W boson branching fraction to hadrons is determined to be 68.32 +- 0.61(stat.) +- 0.28(syst.) % assuming lepton universality. These results are consistent with Standard Model expectations.

Non-freely generated W-algebras and construction of N=2 super W-algebras

International Nuclear Information System (INIS)

Blumenhagen, R.

1994-07-01

Firstly, we investigate the origin of the bosonic W-algebras W(2, 3, 4, 5), W(2, 4, 6) and W(2, 4, 6) found earlier by direct construction. We present a coset construction for all three examples leading to a new type of finitely, non-freely generated quantum W-algebras, which we call unifying W-algebras. Secondly, we develop a manifest covariant formalism to construct N = 2 super W-algebras explicitly on a computer. Applying this algorithm enables us to construct the first four examples of N = 2 super W-algebras with two generators and the N = 2 super W 4 algebra involving three generators. The representation theory of the former ones shows that all examples could be divided into four classes, the largest one containing the N = 2 special type of spectral flow algebras. Besides the W-algebra of the CP(3) Kazama-Suzuki coset model, the latter example with three generators discloses a second solution which could also be explained as a unifying W-algebra for the CP(n) models. (orig.)

Wpływ czynników społeczno-ekonomicznych na zachowania zdrowotne nastolatków mieszkających w Rybniku

Directory of Open Access Journals (Sweden)

Marcin Dudek

2016-12-01

Full Text Available Wstęp. Wpływ czynników społeczno-ekonomicznych na zdrowie od lat jest tematem badań naukowców. Wykazano znaczny wpływ tych czynników na zdrowie populacji. Bezrobocie, niski dochód, migracje oraz status rodziny (pełna, niepełna, rozbita wpływają na zdrowie rodziny i dzieci. Celem pracy było określenie wpływu czynników społeczno-ekonomicznych na zachowania zdrowotne młodzieży zamieszkującej miasto Rybnik. Materiał i metody. Badanie ankietowe przeprowadzono pośród 391 uczniów rybnickich szkół. Poziom majętności rodziny określono za pomocą skali FAS. Za istotny statystycznie przyjęto poziom p<0,05. Wyniki. Badanie wykazało znaczący wpływ statusu rodziny na zachowania zdrowotne, uczniowie z rodzin rozbitych znacznie częściej sięgali po używki, oraz częściej zaniedbywali swoje zdrowie. Podobne wyniki wykazano wśród dzieci migrantów. Status materialny nie determinuje w tak dużym stopniu zachowań zdrowotnych nastolatków. Wnioski. Czynnik społeczno-ekonomiczne silnie determinują zdrowie młodzieży. Szczególnie narażeni na negatywne zachowania zdrowotne są nastolatkowie wychowujący się w rodzinach niepełnych oraz w rodzinach, w których co najmniej jeden z rodziców wyemigrował."

Ocena przydatności kryteriów Williamsa w rozpoznawaniu atopowego zapalenia skóry w praktyce lekarza pediatry

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Zbigniew Samochocki

2009-09-01

Full Text Available O trudnościach w rozpoznawaniu AZS u dzieci świadczy stosowanie wielu różnych metod diagnostycznych. Jedną z nich są kryteria zaproponowane przez Williamsa iwsp. Celem pracy było określenie przydatności kryteriów Williamsa iwsp. wrozpoznawaniu AZS u dzieci poprzez ocenę porównawczą z kryteriami Hanifina iRajki. Badaniami objęto 166 pacjentów Poradni Dermatologicznej (67 chłopców i 99 dziewczynek w wieku od 4 do 15 lat (średnio 10,3 roku, którzy niezależnie od zmian skórnych zgłaszali świąd skóry. Poddano ich badaniu klinicznemu i procedurom zawartym w kryteriach Hanifina i Rajki. Dokonano analizy statystycznej wyników. U 108 dzieci rozpoznano AZS, a u 58 – świerzb, łojotokowe zapalenie skóry, zapalenie skóry z podrażnienia, łuszczycę, trądzik młodzieńczy oraz pokrzywkę. U wszystkich chorych naAZS wykazano suchość skóry. Zajęcie typowych okolic podawane wwywiadzie, początek zmian skórnych <2. roku życia, czynne zmiany w przegubach i osobnicze obciążenie atopią obserwowano odpowiednio u 96,3% (104/108, 71,3% (77/108, 67,6% (73/108 i 64,3% (70/108 pacjentów. Wszystkie te cechy występowały statystycznie istotnie częściej (p<0,001 wporównaniu z grupą dzieci, u których nie rozpoznano wyprysku atopowego. Stosując kryteria Williamsa i wsp., u 3/108 chorych wykazano fałszywie ujemne wyniki, a u 2/58 – fałszywie dodatnie. Czułość i swoistość tej metody badawczej wynosiła odpowiednio 97,2% i 96,6%. Wnioski: 1. Kryteria diagnostyczne Williamsa i wsp. są bardzo pomocne w praktyce lekarza pediatry w rozpoznawaniu AZS u dzieci powyżej 3. roku życia. 2. Suchość skóry i potwierdzenie wwywiadzie obecności zmian wypryskowych o typowej lokalizacji są najbardziej przydatne w rozpoznawaniu AZS u dzieci. 3. W przypadkach wątpliwych rozszerzenie granicy wieku wystąpienia pierwszych zmian skórnych z 2 do 5 lat zwiększa wykrywalność choroby.

Prasa radziecka wydawana w latach 30. XX w. w Republice Niemców Powołża. Wprowadzenie do zagadnienia i uwagi o języku

Directory of Open Access Journals (Sweden)

Jolanta Mędelska

2014-12-01

of the German language used in the USSR, its mixing with Russianisms, especially Sovietisms, including peculiar acronyms (e.g. Ambar, Arbuse, Batrake, Otlitschnik, Partorg, Smytschka, Rote Tafel, Schwarze Tafel, KK der AP(BSU, KVA der ASSR der WD, MTS.   Prasa radziecka wydawana w latach 30. XX w. w Republice Niemców Powołża. Wprowadzenie do zagadnienia i uwagi o języku Autorka przedstawiła pokrótce najważniejsze fakty z historii Niemców rosyjskich (od Manifestu Katarzyny II po powołanie Autonomicznej Socjalistycznej Republiki Radzieckiej Niemców Powołża, zarysowując na tym tle dzieje prasy niemieckojęzycznej w Rosji i wczesnym ZSRR. Skupiła się głównie na tzw. nowej leninowskiej polityce narodowościowej i jej konsekwencjach dla mniejszości niemieckiej. W latach 20. i 30. XX w. w ASRR NP zaczęto masowo drukować po niemiecku książki, podręczniki, broszury, dokumenty, sprawozdania, zwłaszcza zaś materiały propagandowe i prasę. Nowa polityka narodowościowa władz radzieckich sprowadzała się oczywiście do szybkiego i sprawnego indoktrynowania mniejszości narodowych, „wychowywania” ich w duchu ideologii komunistycznej. Dla partii bolszewickiej gazety były zbiorowym propagandystą i agitatorem. Do połowy lat 20. XX w. drukowano w całym ZSRR ponad 70 periodyków niemieckojęzycznych. W Republice Niemców Powołża wydawano 21 gazet w języku niemieckim, m.in. specjalistyczne „Wolgadeutsches Schulblatt”, „Sei bereit”, „Rote Jugend”, głównie jednak prasę kantonową, kołchozową, sowchozową, a nawet gazety ośrodków maszynowych („Lenins Weg”, „Tempo. Bolschewistisches Alltägl. Bulletin”. Często wydawano gazety w języku rosyjskim i ich wersje niemieckojęzyczne, np. „Трудовая правда” i „Arbeiterwahrheit”. Wychodziła też prasa w języku rosyjskim, m.in. „Вперед к победе”. Kwalifikacje dziennikarzy były niskie. Gazety nagminnie zamieszczały relacje tzw. �

Magnetocaloric effects in Mn1.35Fe0.65P1−xSix compounds

International Nuclear Information System (INIS)

Geng Yao-Xiang; Tegus O; Bi Li-Ge

2012-01-01

The structural and magnetocaloric properties of Mn 1.35 Fe 0.65 P 1−x Si x compounds are investigated. The Si-substituted compounds, Mn 1.35 Fe 0.65 P 1−x Si x with x = 0.52, 0.54, 0.55, 0.56, and 0.57, are prepared by high-energy ball milling and the solid-state reaction. The X-ray diffraction shows that the compounds crystallize into the Fe 2 P-type hexagonal structure with space group P6-bar2m. The magnetic measurements show that the Curie temperature of the compound increases from 253 K for x = 0.52 to 296 K for x = 0.56. The isothermal magnetic-entropy change of the Mn 1.35 Fe 0.65 P 1−x Si x compound decreases with the Si content increasing. The maximal value of the magnetic-entropy change is about 7.0 J/kg·K in the Mn 1.35 Fe 0.65 P 0.48 Si 0.52 compound with a field change of 1.5 T. The compound quenched in water possesses a larger magnetic entropy change and a smaller thermal hysteresis than the non-quenched samples. The thermal hysteresis of the compound is less than 3.5 K. The maximum adiabatic temperature change is about 1.4 K in the Mn 1.35 Fe 0.65 P 0.45 Si 0.55 compound with a field change of 1.48 T. (condensed matter: electronic structure, electrical, magnetic, and optical properties)

Xe-135 and Sm-149 Isotopic Evolution Analysis Xesamo code; Analisis de la Evolucion Isotopica del Xe-135 y Sm-149. Programa Xesamo

Energy Technology Data Exchange (ETDEWEB)

Caro, R; Gallego, J; Martinez Fanegas, R

1977-07-01

In this report the time evolution analysis of the nuclides concentration Xe-135 and Sm-149 as a function of the neutron flux is carried out. The neutron flux may be any function of time. It is analyzed as well the reactivity changes associated with the xenon and samarium concentration variations. (Author) 5 refs.

47 CFR 25.135 - Licensing provisions for earth station networks in the non-voice, non-geostationary mobile...

Science.gov (United States)

2010-10-01

... in the non-voice, non-geostationary mobile-satellite service. 25.135 Section 25.135 Telecommunication...-voice, non-geostationary mobile-satellite service. (a) Each applicant for a blanket earth station license in the non-voice, non-geostationary mobile-satellite service shall demonstrate that transceiver...

The calibration of the WISE W1 and W2 Tully-Fisher relation

International Nuclear Information System (INIS)

Neill, J. D.; Seibert, Mark; Scowcroft, Victoria; Tully, R. Brent; Courtois, Hélène; Sorce, Jenny G.; Jarrett, T. H.; Masci, Frank J.

2014-01-01

In order to explore local large-scale structures and velocity fields, accurate galaxy distance measures are needed. We now extend the well-tested recipe for calibrating the correlation between galaxy rotation rates and luminosities—capable of providing such distance measures—to the all-sky, space-based imaging data from the Wide-field Infrared Survey Explorer (WISE) W1 (3.4 μm) and W2 (4.6 μm) filters. We find a correlation of line width to absolute magnitude (known as the Tully-Fisher relation, TFR) of M W1 b,i,k,a =−20.35−9.56(log W mx i −2.5) (0.54 mag rms) and M W2 b,i,k,a =−19.76−9.74(log W mx i −2.5) (0.56 mag rms) from 310 galaxies in 13 clusters. We update the I-band TFR using a sample 9% larger than in Tully and Courtois. We derive M I b,i,k =−21.34−8.95(log W mx i −2.5) (0.46 mag rms). The WISE TFRs show evidence of curvature. Quadratic fits give M W1 b,i,k,a =−20.48−8.36(log W mx i −2.5)+3.60(log W mx i −2.5) 2 (0.52 mag rms) and M W2 b,i,k,a =−19.91−8.40(log W mx i −2.5)+4.32(log W mx i −2.5) 2 (0.55 mag rms). We apply an I-band –WISE color correction to lower the scatter and derive M C W1 =−20.22−9.12(log W mx i −2.5) and M C W2 =−19.63−9.11(log W mx i −2.5) (both 0.46 mag rms). Using our three independent TFRs (W1 curved, W2 curved, and I band), we calibrate the UNION2 Type Ia supernova sample distance scale and derive H 0 = 74.4 ± 1.4(stat) ± 2.4(sys) km s –1 Mpc –1 with 4% total error.

DesinFix TM 135 in fermentation process for bioethanol production

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Dorothee Barth

2014-01-01

Full Text Available Brazil has the world's largest ethanol production from sugarcane, but bacterial contamination decreases the ethanol yields. It was shown that the biocide DesinFixTM 135 can reduce the contamination without decreasing the yeasts' viability or negatively affecting the ethanol production.

Polska w oczach guwernera Skórzewskich, czyli zapiski księdza Pocharda z lat 1792–1833 w zbiorach Biblioteki Uniwersyteckiej w Poznaniu

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Renata Wilgosiewicz-Skutecka

2011-01-01

Full Text Available W zbiorach rękopisów przechowywanych w Bibliotece Uniwersyteckiej w Poznaniu znajdują się trzy tomy wspomnień Claude’a Antoine’a Pocharda – francuskiego księdza, żyjącego w czasach rewolucji francuskiej, należącego do prêtres réfractaires i w roku 1792 zmuszonego do opuszczenia ojczyzny. W latach 1792–1796 pozostawał on na emigracji w Szwajcarii, później przyjął posadę guwernera synów Józefa Skórzewskiego, starosty gnieźnieńskiego, i Heleny z Lipskich Skórzewskiej. Zapiski księdza Pocharda prowadzone w latach 1792–1833 dotyczą obu tych okresów. Ich lektura daje możliwość śledzenia losów duchownego w trudnych czasach rewolucyjnych, a także zagłębienia się w relacje naocznego świadka wydarzeń z życia rodzinnego Skórzewskich, wydarzeń ukazanych w szerszym kontekście historycznym – polskim i europejskim. Artykuł jest wprowadzeniem do badania tych rękopisów jako wielowątkowego materiału mogącego zainteresować zarówno literaturoznawców, jak i historyków, pozwalającego weryfikować wiedzę i stawiać hipotezy dotyczące dziejów jednego z najznamienitszych rodów wielkopolskich.

Polityka rachunkowości w praktyce jednostek gospodarczych w kontekście jej oceny przez biegłych rewidentów

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Katarzyna Świetla

2017-07-01

Full Text Available Ramowy charakter regulacji prawa bilansowego umożliwia jednostkom gospodarczym świadome prowadzenie polityki rachunkowości, które pozwala na kreowanie obrazu przedsiębiorstwa, a tym samym na realizację jego celów i założeń gospodarczych. W artykule, na podstawie analizy literatury przedmiotu i aktów prawnych przedstawiono współczesne problemy związane z tworzeniem polityki rachunkowości i jej dostosowywaniem do indywidualnych potrzeb jednostek gospodarczych. Zaprezentowano także wyniki badań ankietowych przeprowadzonych na grupie polskich biegłych rewidentów. W ich opinii jednostki gospodarcze częściej wykorzystują instrumenty polityki rachunkowości w celu świadomego i celowego kreowania obrazu przedsiębiorstwa, niż w rozmyślnym fałszowaniu sprawozdań finansowych. Autorzy zwracają uwagę na wzrost znaczenia zewnętrznych jednostek konsultingowych w tworzeniu i dostosowywaniu polityki rachunkowości do potrzeb jednostek. Przeprowadzone rozważania skłaniają także do zmiany postrzegania roli biegłego rewidenta w badaniu polityki rachunkowości. W opinii autorów, potwierdzonej wynikami badań, biegły rewident powinien nie tylko sprawdzać zgodność przyjętych rozwiązań z prawem bilansowym, ale też oceniać ich celowość i zasadność w konkretnej sytuacji danej jednostki.

Wyznaczenie krzywej natężenia przepływu w przekroju cofki zbiorników wodnych w Zesławicach

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Bogusław Michalec

2016-03-01

Full Text Available W pracy przedstawiono wyniki pomiarów geodezyjnych i hydrometrycznych oraz obliczeń wykonanych w celu opracowania krzywej natężenia przepływu w przekroju Dłubni, zlokalizowanego w kilometrze 10+247. Pomiary geodezyjne przekroju poprzecznego i spadku podłużnego zwierciadła wody wykonano za pomocą niwelatora Topcon AT-G6, a osiem pomiarów hydrometrycznych wykonano za pomocą młynka indukcyjnego Nautilus C2000 OTT Hydrometrie. Natężenie przepływu obliczono metodą Harlachera na podstawie danych hydrometrycznych i za pomocą wzoru Chézy’ego. Stwierdzono, że przepływy niskie i średnie obliczone wzorem Chézy’ego są średnio pięciokrotnie wyższe od określonych metodą Harlachera. Przyczyną tak znacznych różnic uzyskanych wyników obliczeń natężania przepływu dla danego napełnienia jest układ dna koryta. Stwierdzono, że istotny wpływ na warunki przepływu wody przy przepływach niskich i średnich ma wzniesienie dna w świetle mostu, znajdującego się 203 m poniżej przekroju wodowskazowego. Stwierdzono również, że na kształt krzywej natężenia w tym przekroju ma również wpływ oddziaływanie spiętrzenia wody w zbiornikach w Zesławicach.

Streptococcus pneumonia YlxR at 1.35 A shows a putative new fold.

Science.gov (United States)

Osipiuk, J; Górnicki, P; Maj, L; Dementieva, I; Laskowski, R; Joachimiak, A

2001-11-01

The structure of the YlxR protein of unknown function from Streptococcus pneumonia was determined to 1.35 A. YlxR is expressed from the nusA/infB operon in bacteria and belongs to a small protein family (COG2740) that shares a conserved sequence motif GRGA(Y/W). The family shows no significant amino-acid sequence similarity with other proteins. Three-wavelength diffraction MAD data were collected to 1.7 A from orthorhombic crystals using synchrotron radiation and the structure was determined using a semi-automated approach. The YlxR structure resembles a two-layer alpha/beta sandwich with the overall shape of a cylinder and shows no structural homology to proteins of known structure. Structural analysis revealed that the YlxR structure represents a new protein fold that belongs to the alpha-beta plait superfamily. The distribution of the electrostatic surface potential shows a large positively charged patch on one side of the protein, a feature often found in nucleic acid-binding proteins. Three sulfate ions bind to this positively charged surface. Analysis of potential binding sites uncovered several substantial clefts, with the largest spanning 3/4 of the protein. A similar distribution of binding sites and a large sharply bent cleft are observed in RNA-binding proteins that are unrelated in sequence and structure. It is proposed that YlxR is an RNA-binding protein.

Immunomodulacyjne właściwości makrolidów – zastosowanie w leczeniu chorób układu oddechowego u dzieci

Directory of Open Access Journals (Sweden)

Bolesław Kalicki

2012-11-01

Full Text Available Odmienności budowy i czynności układu oddechowego u dzieci predysponują do częstszego występowania zakażeń. Podstawą działania antybiotyków makrolidowych są ich właściwości bakteriostatyczne wynikające z blokowania podjednostki 50s i 23s rRNA. Makrolidy wykazują szereg dodatkowych działań pozarybosomalnych. Działanie to obejmuje wpływ na komórki układu odpornościowego, odpowiedź cytoki‑ nową, układ oddechowy i metabolizm glikokortykosteroidów. W pracy przedstawiono aktualną wiedzę doty‑ czącą mechanizmów działania tej grupy antybiotyków. Makrolidy zmniejszają ilość neutrofilów w miejscu zapalenia poprzez hamowanie wydzielania czynników chemotaktycznych, blokowanie cząsteczek powierzch‑ niowych biorących udział w procesie migracji oraz kierowanie komórek zapalnych na drogę apoptozy. Wielo‑ kierunkowy wpływ antybiotyków makrolidowych na odpowiedź cytokinową sprowadza się głównie do obni‑ żania wydzielania cytokin prozapalnych i hamowania syntezy tlenku azotu. Ponadto zapobiegają one kolonizacji dróg oddechowych przez P. aeruginosa, co wynika z faktu blokowania przez makrolidy produkcji składników biofilmu, elementów układu quorum sensing (umożliwiającego komunikację się bakterii i hamo‑ wania produkcji czynników zjadliwości. Stosowanie makrolidów zmniejsza również produkcję śluzu w ukła‑ dzie oddechowym i poprawia klirens rzęskowy. Cytowane w opracowaniu badania dowodzą skuteczności makrolidów w zmniejszaniu nadprodukcji śluzu w drogach oddechowych i zapobieganiu kolonizacji przez P. aeruginosa u pacjentów z mukowiscydozą. Ponadto zmniejszają one częstość zaostrzeń i poprawiają jakość życia tych chorych. Nie zaobserwowano jednak istotnej poprawy parametrów spirometrycznych. W przebiegu zakażenia RSV zastosowanie makrolidów powoduje ograniczenie nasilonej reakcji przeciwzapalnej, nadreak‑ tywności oskrzeli i hipersekrecji śluzu, co skutkuje

4-Phenethylthio-2-phenylpyrazolo[1,5-a][1,3,5]triazin-7(6H-one

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Sergey A. Smolnikov

2017-12-01

Full Text Available Exploring the pharmacologically important pyrazolo[1,5-a][1,3,5]triazin-7(6H-one scaffold for the construction of new bioactive compounds, we developed a synthesis of 4-phenethylthio-2-phenylpyrazolo[1,5-a][1,3,5]triazin-7(6H-one (4 via S-alkylation of 2-phenyl-4-thioxopyrazolo[1,5-a][1,3,5]triazine-7(6H-one (3, prepared by the double ring closure of pyrazole and triazine rings upon the treatment of 1-cyanoacetyl-4-benzoylthiosemicarbazide (2 with alkali. The antiproliferative activity of 4 against human lung cancer (A549 and human breast cancer (MDA-MB231 cell lines was investigated. Compound 4 was found to be more active against lung cancer cells than breast cancer cells.

Badania wykorzystania przez polskie biblioteki naukowe środków europejskich, grantów ministerialnych i samorządowych oraz dotacji sponsorów w latach 2000-2008

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Aldona Chachlikowska

2009-01-01

Full Text Available Badania dotyczące pozyskiwania środków pomocowych przez polskie biblioteki naukowe przeprowadzone zostały w ramach wewnętrznych projektów badawczych Biblioteki Uniwersyteckiej w Poznaniu. Realizacji projektu podjął się Oddział Prac Naukowych, Wydawniczych i Dydaktycznych BU. Zadanie wykonano od września 2008 do czerwca 2009 roku. Zamierzeniem autorek artykułu było uzyskanie pełnej informacji na temat środków pozabudżetowych pozyskiwanych przez polskie biblioteki naukowe oraz określenie stopnia ich wykorzystania. Zastosowano metodę sondażu diagnostycznego z wykorzystaniem techniki ankiety. Przygotowany kwestionariusz ankiety wraz z informacją dla respondentów o celu prowadzonych badań skierowano do wszystkich bibliotek uniwersyteckich, bibliotek głównych uczelni technicznych, medycznych, ekonomicznych, bibliotek akademii wychowania fizycznego, uczelni pedagogicznych i rolniczych oraz do bibliotek publicznych posiadających status bibliotek naukowych. Łącznie wysłano 70 ankiet, odpowiedzi udzieliło 38 respondentów. Wskazany w artykule okres 2000-2008 był czasem zwiększonych możliwości uzyskiwania dodatkowych funduszy przez biblioteki. Najczęściej otrzymywane fundusze to dotacje ministerialne, dalej środki sponsorów na działalność podstawową. W poważnym stopniu wspierały biblioteki, głównie biblioteki publiczne, lokalne samorządy. Zauważalne były dotacje wspierające biblioteki przekazywane przez fundacje i środki ofiarowane przez sponsorów na działalność organizacyjną; ewenementem natomiast – subwencje unijne.

1,3,5-Triazine-based analogues of purine: from isosteres to privileged scaffolds in medicinal chemistry.

Science.gov (United States)

Lim, Felicia Phei Lin; Dolzhenko, Anton V

2014-10-06

Purines can be considered as the most ubiquitous and functional N-heterocyclic compounds in nature. Structural modifications of natural purines, particularly using isosteric ring systems, have been in the focus of many drug discovery programs. Fusion of 1,3,5-triazine ring with pyrrole, pyrazole, imidazole, 1,2,3-triazole or 1,2,4-triazole results in seven bicyclic heterocyclic systems isosteric to purine. Application of the isosterism concept for the development of new compounds with therapeutic potential in areas involving purinergic regulation or purine metabolism led to significant advances in medicinal chemistry of the azolo[1,3,5]triazines. These 1,3,5-triazine-based purine-like scaffolds significantly increase level of molecular diversity and allow covering chemical space in the important areas of medicinal chemistry. Some of these azolo[1,3,5]triazine systems have become privileged scaffolds in the development of inhibitors of various kinases, phosphodiesterase, xanthine oxidase, and thymidine phosphorylase, antagonists of adenosine and corticotropin-releasing hormone receptors, anticancer and antiviral agents. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

W-geometry

International Nuclear Information System (INIS)

Hull, C.M.

1993-01-01

The geometric structure of theories with gauge fields of spins two and higher should involve a higher spin generalisation of Riemannian geometry. Such geometries are discussed and the case of W ∝ -gravity is analysed in detail. While the gauge group for gravity in d dimensions is the diffeomorphism group of the space-time, the gauge group for a certain W-gravity theory (which is W ∝ -gravity in the case d=2) is the group of symplectic diffeomorphisms of the cotangent bundle of the space-time. Gauge transformations for W-gravity gauge fields are given by requiring the invariance of a generalised line element. Densities exist and can be constructed from the line element (generalising √detg μν ) only if d=1 or d=2, so that only for d=1,2 can actions be constructed. These two cases and the corresponding W-gravity actions are considered in detail. In d=2, the gauge group is effectively only a subgroup of the symplectic diffeomorphisms group. Some of the constraints that arise for d=2 are similar to equations arising in the study of self-dual four-dimensional geometries and can be analysed using twistor methods, allowing contact to be made with other formulations of W-gravity. While the twistor transform for self-dual spaces with one Killing vector reduces to a Legendre transform, that for two Killing vectors gives a generalisation of the Legendre transform. (orig.)

Organizacja polskiej administracji ogólnej w regionie czarnkowsko-trzcianeckim w 1945 roku

OpenAIRE

Degen, Robert

2012-01-01

Komuniści przejmujący władzę w Polsce latem 1944 roku nie zdecydowali się na wprowadzenie własnego modelu administracji terenowej, który został opracowany kilka miesięcy wcześniej. Jedynymi organami administracji lokalnej miały być w nim rady narodowe. Mimo prób, nieliczne, powstałe w konspiracji rady nie zdały egzaminu w lipcu i sierpniu 1944 r. Dopiero przywrócenie systemu przedwojennych organów administracji lokalnej, uzupełnienie o rady narodowe i obsadzenie ich przez ludzi związanych z k...

Założenia i realizacja polityki zarządzania zasobami w Bibliotece Uniwersyteckiej w Poznaniu w latach 1992–2014

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Małgorzata Dąbrowicz

2015-12-01

Full Text Available W artykule przedstawiono zmiany zachodzące w zarządzaniu zasobami Biblioteki Uniwersyteckiej w Poznaniu w latach 1992–2014. Na podstawie analizy wewnętrznych regulacji dotyczących polityki gromadzenia i związanych z nią zagadnień zaprezentowano jej ewolucję w ostatnim dwudziestoleciu. Omówiono także towarzyszące jej zmiany w organizacji pracy i strukturze oraz zarządzaniu Biblioteką.

Signatures of Parton Exogamy in $e^+ e^- \\to W^+ W^- \\to$ hadrons

CERN Document Server

Ellis, Jonathan Richard; Ellis, John; Geiger, Klaus

1997-01-01

We propose possible signatures of `exogamous' combinations between partons in the different W+ and W- hadron showers in e+e- -> W+W- events with purely hadronic final states. Within the space-time model for hadronic shower development that we have proposed previously, we find a possible difference of about 10 % between the mean hadronic multiplicity in such purely hadronic final states and twice the hadronic multiplicity in events in which one W decays hadronically and the other leptonically, i.e., \

Null fields realizations of W3 from W (sl(4), sl(3)) and W (sl(3/1), sl(3)) algebras

International Nuclear Information System (INIS)

Bellucci, S.; Krivonos, S.; Sorin, A.

1995-09-01

It is considered the nonlinear algebras W(sl(4), sl(3)) and W(sl(3/1), sl(3)) and it is found their realizations in terms of currents spanning conformal linearizing algebras. The specific structure of these algebras, allows to construct realizations modulo null fields of the W 3 algebra that lies in the cosets W(sl(4), sl(3))/u(1) and W(sl(3/1), sl(3))/u(1). Such realizations exist for the following values of the W 3 algebra central charge: cw=-30, -40/7, -98/5, -2. The first two values are listed for the first time, whereas for the remaining values the new realizations get in terms of an arbitrary stress tensor and u(1) x sl(2) affine currents

Białoruskie elementy językowe w rosyjskiej gwarze staroobrzędowców mieszkających w regionie suwalsko-augustowskim

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Dorota Angelika Paśko-Koneczniak

2014-12-01

Full Text Available Elements of the Belarusian language in the Russian dialect used by the Old Believers living in the Suwałki-Augustów region The article deals with the Belarusian elements in the Russian dialect of the Old Believers living in Poland. The Old Believers arrived in Poland in the second half of the 18th century. At present they live in the Suwałki-Augustów region in the north-eastern Poland. They inhabit mostly two villages in the county of Suwałki, namely Gabowe Grądy and Bór, which are very close to each other, and three towns: Augustów, Suwałki and Sejny. The dialect used by the Polish Old Believers represents the western Central Great Russian dialects characterized by akanie, the so-called Pskov group. They share features which are typical of Pskov. The dialect was also influenced by other north-eastern Belarusian dialects, that is, the ones which were closest to the areas originally inhabited by Old Believers, who migrated in phases. After each phase, their dialect came to reflect some new linguistic influences. A large number of lexemes directly borrowed from Polish, or via the Belarusian language, are found in this dialect, which is also characterized by other features common in Belarusian dialects or the Bulgarian language. By way of illustration, they include the following features: the prosthetic j-, prosthetic v-, the occurrence of the endings –im and –ym in the case of singular masculine adjectives in the locative, promotion of the endings –i and –y in the case of the plural masculine and neutral nouns in the nominative, and the occurrence of lexemes borrowed from the Belarusian language.   Białoruskie elementy językowe w rosyjskiej gwarze staroobrzędowców mieszkających w regionie suwalsko-augustowskim Artykuł poświęcony jest problematyce białoruskich elementów językowych w rosyjskiej gwarze staroobrzędowców mieszkających w Polsce. Staroobrzędowcy pojawili się na terytorium Polski w drugiej połowie XVIII

Zastosowanie ketoprofenu w jonoforezie

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Mariola Kowalska

2011-07-01

Full Text Available Dzięki postępom medycyny oraz technologii medycznej możliwe dziś jest stosowanie wielu leków, w tym ketoprofenu, metodą jonoforezy, i to zarówno podczas leczenia sensu stricte, jak i w czasie rehabilitacji pacjenta. Ten sposób leczenia powinien być dostępny na każdym poziomie fizykoterapii według określonych standardów w zakresie rehabilitacji medycznej. Występowanie dolegliwości bólowych jest istotnym problemem zakłó- cającym stan chorego. Pojawienie się incydentów bólowych stanowi kluczowy problem, gdyż mogą one powodować zaburzenia zdrowia i samopoczucia. Istnieje wiele sposobów na zminimalizowanie, zapobieganie i walkę z bólem. Dzięki zastosowaniu medycyny alternatywnej, leczenia farmakologicznego, jak również urzą- dzeń medycznych możemy wybrać odpowiednią metodę w konfrontacji z nim, dostosowaną indywidualnie do potrzeb każdego pacjenta. Niesterydowe leki przeciwbólowe i przeciwzapalne są terapią często wykorzystywaną do uśmierzania bólu ostrego, a także przewlekłego dotyczącego urazów powstałych w narządzie ruchu. Poprzez stosowanie leku metodą jonoforezy można uzyskać efekt przeciwzapalny i przeciwbólowy, z pominięciem doustnej drogi jego podania (per os. Zmienia to dotychczasowy schemat stosowania leków z grupy NLPZ (niesterydowych leków przeciwzapalnych i przeciwbólowych, głównie w przypadku chorób, w przebiegu których skuteczne jest miejscowe podawanie leku zawierającego jako substancję czynną ketoprofen. Zastosowanie jonoforezy umożliwia aplikację około 10-2000 razy więcej cząsteczek leczniczych niż zwykłe nałożenie substancji leczniczej na powierzchnię skóry, np. w postaci żelu.

40 CFR Table 1 to Subpart W of... - General Provisions Applicability to Subpart W

Science.gov (United States)

2010-07-01

... Subpart W 1 Table 1 to Subpart W of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Polyamides Production Pt. 63, Subpt. W, Table 1 Table 1 to Subpart W of Part 63—General Provisions Applicability to Subpart W Reference Applies to subpart W BLR WSR WSR alternative standard, and BLR equipment...

Geopolymers in Construction / Zastosowanie Geopolimerów W Budownictwie

Science.gov (United States)

Błaszczyński, Tomasz Z.; Król, Maciej R.

2015-03-01

Within the framework of quests of supplementary and "healthier" binders to the production of concrete followed the development of geopolymers in construction. However the practical application of these materials is still very limited. The production of each ton of cement introduces one ton of CO2 into the atmosphere. According to various estimations, the synthesis of geopolymers absorbs 2-3 times less energy than the Portland cement and causes a generation of 4-8 times less of CO2. Geopolymeric concretes possess a high compressive strength, very small shrinkage and small creep, and they possess a high resistance to acid and sulphate corrosion. These concretes are also resistant to carbonate corrosion and possess a very high fire resistance and also a high resistance to UV radiation. W ramach poszukiwania zastępczych i "zdrowszych" spoiw do produkcji betonu nastąpił rozwój geopolimerów w budownictwie. Jednakże praktyczne zastosowanie tych materiałów jest jeszcze nadal bardzo ograniczone. Produkcja każdej tony cementu wprowadza do atmosfery tonę CO2. Według różnych szacunków, synteza geopolimerów pochłania 2-3 razy mniej energii, niż cementu portlandzkiego oraz powoduje wydzielenie 4-8 razy mniejszej ilości CO2. Do tego betony geopolimerowe posiadają wysoką wytrzymałość na ściskanie, bardzo mały skurcz i małe pełzanie oraz dają wysoką odporność na korozję kwasową i siarczanową. Betony te są także odporne na korozję węglanową i posiadają bardzo wysoką odporność ogniową, a także wysoką odporność na promieniowanie UV.

Rola histaminy w chorobach reumatycznych

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Przemysław Rzodkiewicz

2010-02-01

Full Text Available Patogeneza chorób reumatycznych wciąż nie jest w pełni wyjaśniona.Delikatna równowaga pomiędzy cytokinami i mediatoramizapalenia odgrywa krytyczną rolę w regulowaniu toczącegosię procesu patologicznego. Histamina jest aminą biogennąmającą udział w patogenezie chorób reumatycznych zarówno wewczesnej fazie zapalenia, jak i w jego przejściu w fazę przewlekłą.Toczącemu się procesowi zapalnemu w chorobach reumatycznychtowarzyszy zwiększone stężenie histaminy w tkankachobjętych procesem zapalnym oraz we krwi. Ekspresja czterechtypów receptorów histaminowych w tkankach stawu wskazujena rolę histaminy w procesie destrukcji chrząstki stawowej.W niniejszej pracy przeglądowej przedyskutowano rolę histaminyw patogenezie reumatoidalnego zapalenia stawów, chorobyzwyrodnieniowej oraz osteoporozy.

Perswazyjność komunikatów reklamowych w Internecie na podstawie analizy usług finansowych SKOK-ów

OpenAIRE

Idzik, Beata

2014-01-01

Praca jest wynikiem kilkuletnich obserwacji praktycznej strony funkcjonowania reklamy w zakresie usług finansowych. Autorka starała się oddać wyraz swojemu zainteresowaniu psychologią konsumenta, marketingiem w sektorze finansowym a także fascynacji możliwościom, jakie stwarzają w tym zakresie nowe technologie oparte na Internecie. Praca ma charakter teoretyczno - badawczy. W założeniach metodologicznych sformułowano problem badawczy, cele oraz cztery hipotezy badawcze, które poddano wery...

Etapy postępowania przymusowego w administracji względem obowiązków niepieniężnych w prawie Polski i Niemiec

OpenAIRE

Ostojski, Przemysław

2013-01-01

Wydział Prawa i Administracji Treść pracy dotyczy nie poruszanego jak dotąd szerzej w polskiej doktrynie prawa i orzecznictwie sądowoadministracyjnym tematu etapów postępowania egzekucyjnego w administracji w Polsce i w Niemczech. W założeniu opracowanie ma być próbą wykazania, iż polskie postępowanie egzekucyjne, podobnie jak niemieckie, składa się z trzech etapów. Wszystkie te etapy w prawie polskim odpowiadają zasadniczo budowie postępowania egzekucyjnego względem obowiązków pieniężnych...

Lektury lekarza – książka Leonarda Botalla w Bibliotece Uniwersyteckiej w Poznaniu

Directory of Open Access Journals (Sweden)

Renata Wilgosiewicz – Skutecka

2009-01-01

Full Text Available Wśród druków francuskich Biblioteki Uniwersyteckiej w Poznaniu znajduje się interesujący zbiór (klocek szesnastowiecznych traktatów medycznych, wydany w Lyonie przez Guillaume’a Rouillé oraz Paula Miraillet, zawierający dwa dzieła Galena: De naturalibus facultatibus libri tres (1548 i De bono et malo succo, liber unus (1547 oraz traktat Donato Antonio Altomare De alteratione, concoctione, digestione, praeparatione, ac purgatione: ex Hippocratis et Galeni sententia methodus (1548. Wolumin ten należał do Leonarda Botalla (1519-1587, włoskiego anatoma i chirurga, medyka królów francuskich, i nosi ślady jego lektury – liczne marginalia, podkreślenia i komentarze w języku łacińskim. Pobieżna analiza tego materiału rękopiśmiennego, zwłaszcza wielu krytycznych uwag Botalla wobec poglądów Galena, pozwala widzieć w tych zapiskach świadectwo przemian zachodzących w medycynie w XVI wieku, która dopiero w tym okresie stała się nauką w pełni nowożytną. Przedstawiona w niniejszym artykule ogólna charakterystyka woluminu jest jedynie wprowadzeniem do szczegółowej analizy zapisków Leonarda Botalla, która pozwoliłaby historykom medycyny dokładniej zrekonstruować poglądy lekarza z Asti, będące świadectwem recepcji dzieł Galena w XVI wieku i toczącej się wokół nich dyskusji.

41 CFR 102-38.135 - What constitutes a public advertisement?

Science.gov (United States)

2010-07-01

... enough in advance of the sale to ensure adequate notice, and to target your advertising efforts toward... OF PERSONAL PROPERTY Sales Process Advertising § 102-38.135 What constitutes a public advertisement... personal property to be sold is considered public advertising. You may also distribute mailings or flyers...

Effects of experimental Neisseria meningitis W135 infection on ...

African Journals Online (AJOL)

AJB SERVER

2006-09-04

Sep 4, 2006 ... oxygen and energy demand at the expense of increased intracranial pressure due to ... multilocus electrophoresis (Selander et al., 1986) at the Central. Laboratory of ..... Part I. Intl. J. Sports Med. 22(7):467–481. Tan TQ ...

PROBLEMATYKA BUDOWLANO–KONSERWATORSKA ZABYTKOWYCH OBIEKTÓW KONSTRUKCJI DREWNIANYCH NA PRZYKŁADZIE KOŚCIOŁA PW. ŚW. MIKOŁAJA BISKUPA W DOMARADZU

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Marek GOSZTYŁA

Full Text Available Problematyka prowadzenia prac rewaloryzacyjnych drewnianych obiektów zabytkowych zaliczana jest do trudniejszych zadań konserwatorskich. Stosowane rozwiązania konstrukcyjne i ciesielskie w XV wieku i późniejszych latach zostały zapomniane przez współczesnych architektów - konserwatorów i brygady ciesielskie. Wykonane prace, które zaliczyć można do rekonstrukcyjnych, w kościele w Domaradzu, dowodzą, że przed przystąpieniem do prac konserwatorskich obiektów zabytkowych, należy wykonywać specjalistyczne badania mykologiczne i studia architektoniczno-konserwatorskie. Dopiero wyniki badań, dają podstawę do formułowania zaleceń konserwatorskich. Przyjęty tok postępowania w kościele, oparty został na metodzie zachowania nawarstwień kulturowych, oryginalnych struktur materiałowych i systemu połączeń ciesielskich. Kolejne etapy prac konserwatorskich, począwszy od wymiany belek podwalinowych, po wzmocnienie konstrukcyjne więźby dachowej, prowadzono po wykonaniu wnikliwych analiz stanu zachowania tychże elementów. W trakcie prac odsłonięto fragmenty wcześniejszych form konstrukcyjnych i polichromii. Odkryta belka, będąca pozostałością tzw. sobót została wyeksponowana, z myślą, ukazania śladów historycznych form architektonicznych obiektu. Metoda ta, jest powszechnie stosowana w postępowaniach konserwatorskich.

Neutron irradiation effects on grain-refined W and W-alloys

International Nuclear Information System (INIS)

Hasegawa, A.; Fukuda, M.; Tanno, T.; Nogami, S.; Yabuuchi, K.; Tanaka, T.; Muroga, T.

2014-10-01

Microstructural data of neutron irradiated Tungsten (W) such as size and number density of voids and precipitates obtained by W up to 1.5dpa irradiation in the temperature range of 400-800degC were compiled quantitatively. Nucleation and growth process of these defects were clarified and a qualitative prediction of the damage structure development and hardening of W in fusion reactor environments were made taking into account the solid transmutation effects for the first time. To improve recrystallization behavior and low temperature embrittlement, grain refined-W alloys were fabricated by K- or La-doping method. Rhenium addition to the grain refining process was also examined to improve mechanical properties. Characterizations of unirradiated materials were performed. (author)

The Vitotox and ToxTracker assays: A two-test combination for quick and reliable assessment of genotoxic hazards.

Science.gov (United States)

Ates, Gamze; Favyts, Dorien; Hendriks, Giel; Derr, Remco; Mertens, Birgit; Verschaeve, Luc; Rogiers, Vera; Y Doktorova, Tatyana

2016-11-01

To ensure safety for humans, it is essential to characterize the genotoxic potential of new chemical entities, such as pharmaceutical and cosmetic substances. In a first tier, a battery of in vitro tests is recommended by international regulatory agencies. However, these tests suffer from inadequate specificity: compounds may be wrongly categorized as genotoxic, resulting in unnecessary, time-consuming, and expensive in vivo follow-up testing. In the last decade, novel assays (notably, reporter-based assays) have been developed in an attempt to overcome these drawbacks. Here, we have investigated the performance of two in vitro reporter-based assays, Vitotox and ToxTracker. A set of reference compounds was selected to span a variety of mechanisms of genotoxic action and applicability domains (e.g., pharmaceutical and cosmetic ingredients). Combining the performance of the two assays, we achieved 93% sensitivity and 79% specificity for prediction of gentoxicity for this set of compounds. Both assays permit quick high-throughput analysis of drug candidates, while requiring only small quantities of the test substances. Our study shows that these two assays, when combined, can be a reliable method for assessment of genotoxicity hazard. Copyright © 2016 Elsevier B.V. All rights reserved.

LiverTox: Advanced QSAR and Toxicogeomic Software for Hepatotoxicity Prediction

Energy Technology Data Exchange (ETDEWEB)

Lu, P-Y.; Yuracko, K. (YAHSGS, LLC)

2011-02-25

YAHSGS LLC and Oak Ridge National Laboratory (ORNL) established a CRADA in an attempt to develop a predictive system using a pre-existing ORNL computational neural network and wavelets format. This was in the interest of addressing national needs for toxicity prediction system to help overcome the significant drain of resources (money and time) being directed toward developing chemical agents for commerce. The research project has been supported through an STTR mechanism and funded by the National Institute of Environmental Health Sciences beginning Phase I in 2004 (CRADA No. ORNL-04-0688) and extending Phase II through 2007 (ORNL NFE-06-00020). To attempt the research objectives and aims outlined under this CRADA, state-of-the-art computational neural network and wavelet methods were used in an effort to design a predictive toxicity system that used two independent areas on which to base the system’s predictions. These two areas were quantitative structure-activity relationships and gene-expression data obtained from microarrays. A third area, using the new Massively Parallel Signature Sequencing (MPSS) technology to assess gene expression, also was attempted but had to be dropped because the company holding the rights to this promising MPSS technology went out of business. A research-scale predictive toxicity database system called Multi-Intelligent System for Toxicogenomic Applications (MISTA) was developed and its feasibility for use as a predictor of toxicological activity was tested. The fundamental focus of the CRADA was an attempt and effort to operate the MISTA database using the ORNL neural network. This effort indicated the potential that such a fully developed system might be used to assist in predicting such biological endpoints as hepatotoxcity and neurotoxicity. The MISTA/LiverTox approach if eventually fully developed might also be useful for automatic processing of microarray data to predict modes of action. A technical paper describing the

NNLOPS accurate predictions for $W^+W^-$ production arXiv

CERN Document Server

Re, Emanuele; Zanderighi, Giulia

We present novel predictions for the production of $W^+W^-$ pairs in hadron collisions that are next-to-next-to-leading order accurate and consistently matched to a parton shower (NNLOPS). All diagrams that lead to the process $pp\\to e^- \\bar \

Crystal structure of (OC5W(μ-dppeW(CO5

Directory of Open Access Journals (Sweden)

Hannah F. Drake

2016-10-01

Full Text Available The centrosymmetric title complex, [μ-ethane-1,2-diylbis(diphenylphosphane-κ2P:P′]bis[pentacarbonyltungsten(0], [W2(C26H24P2(CO10], consists of two W(CO5 moieties bridged by a bis(diphenylphosphanylethane (dppe ligand. The W0 atom has a slightly distorted octahedral coordination environment consisting of 5 carbonyl ligands and one P atom from the bridging dppe ligand with the nearest W0 atom 5.625 (5 Å away. The complex resides on a center of symmetry.

W+W- production at the LHC. Fiducial cross sections and distributions in NNLO QCD

International Nuclear Information System (INIS)

Grazzini, Massimiliano; Wiesemann, Marius; Kallweit, Stefan; California Univ., Santa Barbara, CA; Pozzorini, Stefano; California Univ., Santa Barbara, CA; Rathlev, Dirk

2016-05-01

We consider QCD radiative corrections to W + W - production at the LHC and present the first fully differential predictions for this process at next-to-next-to-leading order (NNLO) in perturbation theory. Our computation consistently includes the leptonic decays of the W bosons, taking into account spin correlations, off-shell effects and non-resonant contributions. Detailed predictions are presented for the different-flavour channel pp→μ + e - ν μ anti ν e +X at √(s)=8 and 13 TeV. In particular, we discuss fiducial cross sections and distributions in the presence of standard selection cuts used in experimental W + W - and H→W + W - analyses at the LHC. The inclusive W + W - cross section receives large NNLO corrections, and, due to the presence of a jet veto, typical fiducial cuts have a sizeable influence on the behaviour of the perturbative expansion. The availability of differential NNLO predictions, both for inclusive and fiducial observables, will play an important role in the rich physics programme that is based on precision studies of W + W - signatures at the LHC.

Yeast Interacting Proteins Database: YPL022W, YLR135W [Yeast Interacting Proteins Database

Lifescience Database Archive (English)

Full Text Available repair; cleaves branched structures in a complex with Slx1p; involved in Rad1p/Rad10p-dependent removal of ... Prey gene name SLX4 Prey description Endonuclease involved in processing DNA during recombination and repair; cleaves branched struc...tures in a complex with Slx1p; involved in Rad1p/Rad10p-dependent removal of 3'-non

Potential of the FLASH FEL technology for the construction of a kW-scale light source for the next generation lithography

Energy Technology Data Exchange (ETDEWEB)

Schneidmiller, E.A.; Vogel, V.F.; Weise, H.; Yurkov, M.V.

2011-08-15

The driving engine of the Free Electron Laser in Hamburg (FLASH) is an L-band superconducting accelerator. It is designed to operate in burst mode with 800 microsecond pulse duration at a repetition rate of 10 Hz. The maximum accelerated beam current during the macropulse is 9 mA. Our analysis shows that the FLASH technology has great potential since it is possible to construct a FLASH like free electron laser operating at the wavelength of 13.5 and 6.8 nanometer with an average power up to 2.6 kW. Such a source meets the physical requirements for the light source for the next generation lithography. (orig.)

Investigations of Chemical and Biological Treatment Options for the Attenuation of Hexahydro-1,3,5-trinitro-1,3,5-triazine Contamination in Groundwater at Los Alamos, New Mexico

Science.gov (United States)

Heerspink, B. P.; Wang, D.; Ware, D.; Marina, O.; Perkins, G.; WoldeGabriel, G. W.; Goering, T.; Boukhalfa, H.

2017-12-01

High-explosive compounds including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) were used extensively in weapons research and testing at Los Alamos National Laboratory (LANL) in Los Alamos, NM. Liquid effluents containing RDX released at LANL's Technical Area 16 (TA-16) resulted in the contamination of alluvial, perched-intermediate, and regional groundwater bodies. Past investigations have shown persistent RDX contamination in the perched-intermediate zone located between 225 to 311 m below ground surface, where transport studies have shown that RDX and its degradation products transport conservatively. In this study, we compared RDX degradation by chemical treatments using reduction by sodium dithionite, oxidation by potassium permanganate, and alkaline hydrolysis by carbonate/bicarbonate buffering, with microbial degradation under biostimulated conditions. The experiments were conducted using groundwater and sediments representative of the contaminated aquifer beneath TA-16. Batch testing showed that all chemical treatments degraded RDX very rapidly, with half-lives ranging from 50 minutes to 22 hours. Comparatively, RDX degradation in biostimulated reactors under strict anaerobic conditions was significantly slower, with half-lives of about 3 weeks. Results from column experiments with chemically treated sediments deviated from the results of the batch testing. Dithionite treated sediments reduced RDX with no breakthrough observed before clogging occurred at 50 pour volumes. Treatments by oxidation using potassium permanganate, and hydrolysis under buffered alkaline conditions, were less effective with complete RDX breakthrough after 2 pore volumes. No known degradation products were observed in the column effluents. RDX degradation in biostimulated columns was very effective initially for both treatments. However, the column biostimulated with safflower oil clogged very rapidly. The column biostimulated with molasses was very effective when molasses was

Search for triboson W{sup ±}W{sup ±}W{sup -+} production in pp collisions at √(s) = 8 TeV with the ATLAS detector

Energy Technology Data Exchange (ETDEWEB)

Aaboud, M. [Univ. Mohamed Premier et LPTPM, Oujda (Morocco). Faculte des Sciences; Aad, G. [CPPM, Aix-Marseille Univ. et CNRS/IN2P3, Marseille (France); Abbott, B. [Oklahoma Univ., Norman, OK (United States). Homer L. Dodge Dept. of Physics and Astronomy; Collaboration: ATLAS Collaboration; and others

2017-03-15

This paper reports a search for triboson W{sup ±}W{sup ±}W{sup -+} production in two decay channels (W{sup ±}W{sup ±}W{sup -+} → l{sup ±}νl{sup ±}νl{sup -+}ν and W{sup ±}W{sup ±}W{sup -+} → l{sup ±}νl{sup ±}νjj with l = e, μ) in proton-proton collision data corresponding to an integrated luminosity of 20.3 fb{sup -1} at a centre-of-mass energy of 8 TeV with the ATLAS detector at the Large Hadron Collider. Events with exactly three charged leptons, or two leptons with the same electric charge in association with two jets, are selected. The total number of events observed in data is consistent with the Standard Model (SM) predictions. The observed 95% confidence level upper limit on the SM W{sup ±}W{sup ±}W{sup -+} production cross section is found to be 730 fb with an expected limit of 560 fb in the absence of SM W{sup ±}W{sup ±}W{sup -+} production. Limits are also set on WWWW anomalous quartic gauge couplings. (orig.)

Współczesna architektura wieżowców w stolicy Kataru – Dausze

Directory of Open Access Journals (Sweden)

Jerzy Szołomicki

2017-12-01

Full Text Available W artykule przedstawiono elementy analizy architektonicznej i konstrukcyjnej wybranych wieżowców ze stolicy Kataru Dohy zlokalizowanych w dzielnicy biznesowej West Bay oraz w kompleksie sportowym Aspire Zone. Analizując architekturę Dohy można stwierdzić, że obecnie jest to bardzo szybko rozwijająca się metropolia, która jest uznawana wraz z Dubajem za najbardziej zaawansowane technologicznie miasto świata w kategorii budynków inteligentnych. Koniunktura budowlana i rozwój konstrukcyjny spowodowały wznoszenie ikonicznych wieżowców, obiektów widowiskowo-sportowych oraz muzeów. W pierwszej części artykułu zwrócono uwagę na to jak w ciągu kilkunastu lat Doha dołączyła do najciekawszych architektonicznie miast świata ze względu na gwałtowny rozwój gospodarczy wynikający ze znalezienia ogromnych złóż ropy naftowej i gazu ziemnego. Punktem zwrotnym była organizacja XV Igrzysk Azjatyckich w 2006 roku. W wyniku sukcesu ekonomicznego tych igrzysk ponad 100 budynków wysokich i wysokościowych było planowanych do budowy w dzielnicy biznesowej West Bay i przyległych dzielnicach. Oczywiście rozwój architektoniczny miasta nie mógłby się odbyć bez uczestnictwa w nim wybitnych zagranicznych architektów takich, jak na przykład Jean Nouvell, Ieoh Pei, czy Arata Isozaki. W drugiej części artykułu omówiono wieżowce w dzielnicy West Bay: Doha Tower, Al Bidda Tower, Tornado Tower oraz znajdującą się w kompleksie sportowym Aspire Tower. Budynki te stanowią obecnie znak rozpoznawczy Kataru na całym świecie.

Nowy sposób wytwarzania odlewów precyzyjnych ze stopu miedzi w formach ceramicznych

Directory of Open Access Journals (Sweden)

E. Czekaj

2012-12-01

Full Text Available W publikacji zaprezentowano wyniki badań odlewów wytwarzanych ze stopu miedzi (brązu aluminiowego, typu BA1044 wedługopracowanej w Instytucie Odlewnictwa w Krakowie technologii wykonywania odlewów precyzyjnych przy zastosowaniu kierunkowegokrzepnięcia [9]. Wstępnie pokazano zasadność nowoopracowanego w Polsce sposobu wytwarzania skomplikowanych konstrukcyjnie, azarazem wysokojakościowych (z uwagi na właściwości użytkowe części maszyn, urządzeń i pojazdów ze stopów miedzi. Proponowanerozwiązanie jest innowacją nie tylko w skali kraju (Polski, ale również o zasięgu międzynarodowym.

The study of the reaction e+e-→W+W-

International Nuclear Information System (INIS)

Blondel, A.; Raimondi, P.; Schlatter, W.

1987-01-01

The reaction e + e - →W + W - provides an unique opportunity to test some important aspects of the Standard Model. After a review of the basic relevant measurements, data are presented which simulate the performance of LEP detectors for this process around 95 GeV beam energy. Of particular interest are measurements of the W helicity providing new information on the process. The role of beam polarization is discussed in some detail. 32 figs; 15 refs

Simultaneous genotyping of HPA-17w to -21w by PCR-SSP in Chinese Cantonese.

Science.gov (United States)

Zhou, Haojie; Ding, Haoqiang; Chen, Yangkai; Li, Xiaofan; Ye, Xin; Nie, Yongmei

2015-01-01

Studies have reported the polymorphism of human platelet antigen (HPA)-17w, -18w, -19w, -20w, and -21w. However, the distribution of these five antigens in Chinese Cantonese is still unknown. In this study, we designed new sequence-specific primers for HPA-19w to -21w and used published primers for HPA-17w and -18w to develop a polymerase chain reaction with the sequence-specific primers (PCR-SSP) method for simultaneously genotyping HPA-17w to -21w. A total of 820 unrelated Cantonese apheresis platelet donors in Guangzhou were involved in this study. Among the five HPAs, complete a/a homozygosity was observed for HPA-17w to -20w with an allele frequency of 1.0000. For HPA-21w, nine individuals (9/820, 1.10%) were found to be HPA-21a/bw heterozygous and the allele frequencies of HPA-21a and HPA-21bw were 0.9945 (1631/1640) and 0.0055 (9/1640), respectively. The reliability of the PCR-SSP method was determined by comparing with the genotyping results by DNA sequencing, and no inconsistencies were observed between the two methods. This study provides a reliable PCR-SSP method for simultaneously genotyping HPA-17w to -21w and could improve HPA-matched platelet transfusion in Chinese Cantonese.

Measurement of thermal neutron cross section and resonance integral of the reaction {sup 135}Cs(n,{gamma}){sup 136}Cs