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  1. Rotavirus Recombinant VP6 Nanotubes Act as an Immunomodulator and Delivery Vehicle for Norovirus Virus-Like Particles

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    Maria Malm

    2016-01-01

    Full Text Available We have recently shown that tubular form of rotavirus (RV recombinant VP6 protein has an in vivo adjuvant effect on the immunogenicity of norovirus (NoV virus-like particle (VLP vaccine candidate. In here, we investigated in vitro effect of VP6 on antigen presenting cell (APC activation and maturation and whether VP6 facilitates NoV VLP uptake by these APCs. Mouse macrophage cell line RAW 264.7 and dendritic cell line JAWSII were used as model APCs. Internalization of VP6, cell surface expression of CD40, CD80, CD86, and major histocompatibility class II molecules, and cytokine and chemokine production were analyzed. VP6 nanotubes were efficiently internalized by APCs. VP6 upregulated the expression of cell surface activation and maturation molecules and induced secretion of several proinflammatory cytokines and chemokines. The mechanism of VP6 action was shown to be partially dependent on lipid raft-mediated endocytic pathway as shown by methyl-β-cyclodextrin inhibition on tumor necrosis factor α secretion. These findings add to the understanding of mechanism by which VP6 exerts its immunostimulatory and immunomodulatory actions and further support its use as a part of nonlive RV-NoV combination vaccine.

  2. Rotavirus capsid VP6 tubular and spherical nanostructures act as local adjuvants when co-delivered with norovirus VLPs.

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    Malm, M; Heinimäki, S; Vesikari, T; Blazevic, V

    2017-09-01

    A subunit protein vaccine candidate based on norovirus (NoV) virus-like particles (VLPs) and rotavirus (RV) VP6 protein against acute childhood gastroenteritis has been proposed recently. RV VP6 forms different oligomeric nanostructures, including tubes and spheres when expressed in vitro, which are highly immunogenic in different animal models. We have shown recently that recombinant VP6 nanotubes have an adjuvant effect on immunogenicity of NoV VLPs in mice. In this study, we investigated if the adjuvant effect is dependent upon a VP6 dose or different VP6 structural assemblies. In addition, local and systemic adjuvant effects as well as requirements for antigen co-delivery and co-localization were studied. The magnitude and functionality of NoV GII.4-specific antibodies and T cell responses were tested in mice immunized with GII.4 VLPs alone or different combinations of VLPs and VP6. A VP6 dose-dependent adjuvant effect on GII.4-specific antibody responses was observed. The adjuvant effect was found to be strictly dependent upon co-administration of NoV GII.4 VLPs and VP6 at the same anatomic site and at the same time. However, the adjuvant effect was not dependent on the types of oligomers used, as both nanotubes and nanospheres exerted adjuvant effect on GII.4-specific antibody generation and, for the first time, T cell immunity. These findings elucidate the mechanisms of VP6 adjuvant effect in vivo and support its use as an adjuvant in a combination NoV and RV vaccine. © 2017 The Authors. Clinical & Experimental Immunology published by John Wiley & Sons Ltd on behalf of British Society for Immunology.

  3. VP6: A candidate rotavirus vaccine.

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    Ward, Richard L; McNeal, Monica M

    2010-09-01

    Several nonliving rotavirus vaccine candidates have been evaluated in animal models. Among them is the VP6 protein that comprises the intermediate layer of the rotavirus particle. This protein was expressed as a chimera with maltose binding protein (MBP::VP6) and was administered intranasally to mice. When later challenged with rotavirus, vaccinated mice were nearly 100% protected from fecal shedding of rotavirus, a result strictly dependent on coadministration of an effective adjuvant. Protection was stimulated by only 1 dose of MBP::VP6, remained fully intact for at least 1 year, was effective in all strains of mice tested, and could also be effectively delivered orally or intrarectally. When VP6 was derived from a human rotavirus, it stimulated protection comparable to that found when derived from the challenge murine EDIM strain. In contrast to live rotavirus vaccines, CD4(+) T cells were found to be the only lymphocytes required for protection. If VP6 elicits comparable protection in humans, it would represent a potential second-generation vaccine candidate.

  4. Structure based modification of Bluetongue virus helicase protein VP6 to produce a viable VP6-truncated BTV

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    Matsuo, Eiko [Microbiology and Immunology, Division of Animal Science, Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, 1-1, Rokkodai, Nada-ku, Kobe-City 657-8501 (Japan); Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT (United Kingdom); Leon, Esther; Matthews, Steve J. [Division of Molecular Biosciences, Centre for Structural Biology, Imperial College London, South Kensington, London SW7 2AZ (United Kingdom); Roy, Polly, E-mail: polly.roy@lshtm.ac.uk [Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT (United Kingdom)

    2014-09-05

    Highlights: • NMR analysis on BTV VP6 reveals two large loop regions. • The loss of a loop (aa 34–130) does not affect the overall fold of the protein. • A region of VP6 (aa 34–92) is not required for BTV replication. • A region of VP6 (aa 93–130) plays an essential role in the virus replication. - Abstract: Bluetongue virus core protein VP6 is an ATP hydrolysis dependent RNA helicase. However, despite much study, the precise role of VP6 within the viral capsid and its structure remain unclear. To investigate the requirement of VP6 in BTV replication, we initiated a structural and biological study. Multinuclear nuclear magnetic resonance spectra were assigned on his-tagged full-length VP6 (329 amino acid residues) as well as several truncated VP6 variants. The analysis revealed a large structured domain with two large loop regions that exhibit significant conformational exchange. One of the loops (amino acid position 34–130) could be removed without affecting the overall fold of the protein. Moreover, using a BTV reverse genetics system, it was possible to demonstrate that the VP6-truncated BTV was viable in BHK cells in the absence of any helper VP6 protein, suggesting that a large portion of this loop region is not absolutely required for BTV replication.

  5. VP6-SUMO Self-Assembly as Nanocarriers for Gastrointestinal Delivery

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    V. Palmieri

    2015-01-01

    Full Text Available High proteolytic degradation and poor absorption through epithelial barriers are major challenges to successful oral delivery of therapeutics. Nanoparticle platforms can enhance drug stability and extend the residence time in gastrointestinal (GI tract. However, drug delivery systems are often inactivated in acidic environment of stomach or suffer poor absorption from intestinal cells due to the mucus layer. To overcome these issues we developed a drug delivery system constituted by a protein construct made by a Rotavirus capsid protein (VP6 and the small ubiquitin-like modifier SUMO. This chimeric construct allows specificity towards intestinal cells, the Rotavirus natural target, combined by an enhanced stability given by the eukaryotic protein transporter SUMO. Furthermore SUMO can act as a molecular switch that facilitates import/export of its ligand to the nucleus, the hypersensitive subcellular site target of many cell killing therapies. In this paper we show that SUMO-VP6 constructs self-assembly into stable nanocarriers. SUMO-VP6 nanocarriers display ideal features for drug delivery: a small size and high monodispersity, a high stability in different pH conditions and a high uptake in the nuclear and cytoplasmic compartment of intestinal cells. These features make SUMO-VP6 nanocarriers a promising novel system for oral delivery of poorly soluble drugs.

  6. Autism: Why Act Early?

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    ... this? Submit What's this? Submit Button Past Emails Autism: Why Act Early? Language: English (US) Español (Spanish) ... helped the world make sense." Florida teenager with Autism Spectrum Disorder "Because my parents acted early, I ...

  7. Evaluation of a bovine rotavirus VP6 vaccine efficacy in the calf model of infection and disease.

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    Gonzalez, Diego Daniel; Mozgovoj, Marina Valeria; Bellido, Demian; Rodriguez, Daniela Vanesa; Fernandez, Fernando María; Wigdorovitz, Andrés; Parreño, Viviana Gladys; Dus Santos, María José

    2010-09-15

    Group A bovine rotavirus (BRV) is the major cause of acute viral gastroenteritis in neonatal calves worldwide. Due to the early susceptibility to the infection prevention strategies are based on the improvement of passive immunity levels through cow vaccination in the last third of gestation. The major capsid antigen (VP6) of BRV is the most immunogenic viral protein and it is highly conserved among group A BRV. In this work, VP6 protein from BRV C-486 strain (P[1]G6) was expressed in insect cells using the baculovirus expression vector system. Recombinant VP6 was used to immunize cows and vaccine's efficacy was assessed in a colostrum-deprived calf model of BRV infection and disease. Immune colostrum pool was generated using first and second milking of the immunized cows. Calves receiving one dose of immune colostrum within the first 6h of life, or colostrum-deprived calves were orally inoculated with virulent BRV at 2 days of age. The animals were monitored for diarrhea, virus shedding and isotype-specific antibodies responses to BRV in both feces and serum. Calves receiving VP6-immune colostrum showed a reduction of both diarrhea and virus shedding (in terms of viral titer and excretion period) in comparison with the colostrum-deprived calves. Copyright 2010 Elsevier B.V. All rights reserved.

  8. Molecular cloning and sequence analysis of VP6 gene of giant ...

    African Journals Online (AJOL)

    Rotavirus (family Reoviridae) is the leading cause of severe gastroenteritis in human and animals worldwide. The genome of rotavirus comprises of 11 segments of dsRNA and encodes six structural proteins (VP1 to VP4, VP6 and VP7) and six non structural proteins (NSP1 to NSP6). VP6 is a group of antigen of rotavirus ...

  9. Comparative immunogenicity in mice of rotavirus VP6 tubular structures and virus-like particles.

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    Lappalainen, Suvi; Tamminen, Kirsi; Vesikari, Timo; Blazevic, Vesna

    2013-09-01

    Rotavirus (RV) is the most important cause of severe gastroenteritis in children worldwide. Current live RV vaccines are efficacious but show lower efficacy in developing countries, as well as a low risk of intussusception. This has led to the development of parenteral non-live candidate vaccines against RV. RV capsid VP6 protein is highly conserved and the most abundant RV protein forming highly immunogenic oligomeric structures with multivalent antigen expression. Both recombinant VP6 (rVP6) or double-layered (dl) 2/6-virus-like particles (VLPs), might be considered as the simplest RV subunit vaccine candidates. Human rVP6 protein and dl2/6-VLPs were produced in Sf9 insect cells by baculovirus expression system. Formation of rVP6 tubules and VLPs were confirmed by electron microscopy. BALB/c mice were immunized intramuscularly, and immune responses were analyzed. Both rVP6 and dl2/6-VLPs induced a balanced Th1-type and Th2-type response and high levels of serum IgG antibodies with cross-reactivity against different RV strains (Wa, SC2, BrB, 69M, L26, WC3, and RRV). In addition, mucosal VP6-specific IgG and IgA antibodies were detected in feces and vaginal washes (VW) of immunized animals. Importantly, VWs of immunized mice inhibited RV Wa and RRV infection in vitro. Immunization with either protein preparation induced a similar level of VP6-specific, interferon-γ secreting CD4(+) T cells in response to different RVs or the 18-mer peptide (AA 242-259), a VP6-specific CD4(+) T cell epitope. RV rVP6 and dl2/6-VLPs induced equally strong humoral and cellular responses against RV in mice and therefore, may be considered as non-live vaccine candidates against RV.

  10. A time-resolved immunoassay to measure serum antibodies to the rotavirus VP6 capsid protein

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    Kavanagh, Owen; Zeng, Xi-Lei; Ramani, Sasirekha; Mukhopadhya, Indrani; Crawford, Sue E.; Kang, Gagandeep; Estes, Mary K.

    2013-01-01

    The rotavirus (RV) inner capsid protein VP6 is widely used to evaluate immune response during natural infection and in vaccine studies. Recombinant VP6 from the most prevalent circulating rotavirus strains in each subgroup (SG) identified in a birth cohort of children in southern India [SGII (G1P[8]) and SGI (G10P[11])] were produced. The purified proteins were used to measure VP6-specific antibodies in a Dissociation-Enhanced Lanthanide Fluorometric Immunoassay (DELFIA). The ability of the a...

  11. Antigenicity and Immunogenicity of Rotavirus VP6 Protein Expressed on the Surface of Lactococcus lactis

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    L. E. Esteban

    2013-01-01

    Full Text Available Group A rotaviruses are the major etiologic agents of acute gastroenteritis worldwide in children and young animals. Among its structural proteins, VP6 is the most immunogenic and is highly conserved within this group. Lactococcus lactis is a food-grade, Gram-positive, and nonpathogenic lactic acid bacteria that has already been explored as a mucosal delivery system of heterologous antigens. In this work, the nisin-controlled expression system was used to display the VP6 protein at the cell surface of L. lactis. Conditions for optimal gene expression were established by testing different nisin concentrations, cell density at induction, and incubation times after induction. Cytoplasmic and cell wall protein extracts were analyzed by Western blot and surface expression was confirmed by flow cytometry. Both analysis provided evidence that VP6 was efficiently expressed and displayed on the cell surface of L. lactis. Furthermore, the humoral response of mice immunized with recombinant L. lactis was evaluated and the displayed recombinant VP6 protein proved to be immunogenic. In conclusion, this is the first report of displaying VP6 protein on the surface of L. lactis to induce a specific immune response against rotavirus. These results provide the basis for further evaluation of this VP6-displaying L. lactis as a mucosal delivery vector in a mouse model of rotavirus infection.

  12. A new rotavirus VP6-based foreign epitope presenting vector and immunoreactivity of VP4 epitope chimeric proteins.

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    Teng, Yumei; Zhao, Bingxin; Pan, Xiaoxia; Wen, Yuling; Chen, Yuanding

    2014-04-01

    The VP6, the group antigenic rotavirus (RV), is highly conserved and the most abundant, constituting about 39% of the viral structure proteins by weight. The high degree of identity (>87%-99%) in the primary amino acid sequences suggests VP6-based vaccines could potentially provide heterotypic protection. Although some efforts have been made toward producing recombinant rotavirus VP6 vaccines, the native VP6 is still unsatisfactory as an optimal vaccine. The major neutralizing antigenic epitopes that exist on VP4 or VP7 are not on the native VP6, and as a vector the native VP6 lacks insertion sites that can be used for insertion of foreign epitopes. In this study, a new foreign epitope presenting system using VP6 as a vector (VP6F) was constructed on the outer surface of the vector six sites that could be used for insertion of the foreign epitopes created. Using this system, three VP6-based VP4 epitope chimeric proteins were constructed. Results showed that these chimeric proteins reacted with anti-VP6 and -VP4 antibodies, and elicited antibodies against VP6 and VP4 in guinea pigs. Antibodies against VP6F or antibodies against the chimeric proteins neutralized RV Wa and SA11 infection in vitro. It is optimistic that the limitation for using the native VP6 as a vaccine candidate or vector will be solved with our proposed approach. It is expected that this VP6-based epitope presenting system and the VP6-based VP4 epitope chimeric proteins will be valuable for and contribute to the development of novel RV vaccines and vaccine vectors.

  13. [Immunoreactivity of chimeric proteins carrying poliovirus epitopes on the VP6 of rotavirus as a vector].

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    Pan, X-X; Zhao, B-X; Teng, Y-M; Xia, W-Y; Wang, J; Li, X-F; Liao, G-Y; Yang, С; Chen, Y-D

    2016-01-01

    Rotavirus and poliovirus continue to present significant risks and burden of disease to children in developing countries. Developing a combined vaccine may effectively prevent both illnesses and may be advantageous in terms of maximizing compliance and vaccine coverage at the same visit. Recently, we sought to generate a vaccine vector by incorporating multiple epitopes into the rotavirus group antigenic protein, VP6. In the present study, a foreign epitope presenting a system using VP6 as a vector was created with six sites on the outer surface of the vector that could be used for insertion of foreign epitopes, and three VP6-based PV1 epitope chimeric proteins were constructed. The chimeric proteins were confirmed by immunoblot, immunofluorescence assay, and injected into guinea pigs to analyze the epitope-specific humoral response. Results showed that these chimeric proteins reacted with anti-VP6F and -PV1 antibodies, and elicited antibodies against both proteins in guinea pigs. Antibodies against the chimeric proteins carrying PV1 epitopes neutralized rotavirus Wa and PV1 infection in vitro. Our study contributes to a better understanding of the use of VP6-based vectors as multiple-epitope delivery vehicles and the epitopes displayed in this form could be considered for development of epitope-based vaccines against rotavirus and poliovirus.

  14. A time-resolved immunoassay to measure serum antibodies to the rotavirus VP6 capsid protein.

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    Kavanagh, Owen; Zeng, Xi-Lei; Ramani, Sasirekha; Mukhopadhya, Indrani; Crawford, Sue E; Kang, Gagandeep; Estes, Mary K

    2013-04-01

    The rotavirus (RV) inner capsid protein VP6 is widely used to evaluate immune response during natural infection and in vaccine studies. Recombinant VP6 from the most prevalent circulating rotavirus strains in each subgroup (SG) identified in a birth cohort of children in southern India [SGII (G1P[8]) and SGI (G10P[11])] were produced. The purified proteins were used to measure VP6-specific antibodies in a Dissociation-Enhanced Lanthanide Fluorometric Immunoassay (DELFIA). The ability of the assay to detect a ≥2 fold rise in IgG level in a panel of serum samples from a longitudinal study was compared to a gold standard virus-capture ELISA. A strong association was observed between the assays (pcorrelate of protection. Copyright © 2012 Elsevier B.V. All rights reserved.

  15. Bioinformatic analysis suggests that the Orbivirus VP6 cistron encodes an overlapping gene

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    Firth Andrew E

    2008-04-01

    Full Text Available Abstract Background The genus Orbivirus includes several species that infect livestock – including Bluetongue virus (BTV and African horse sickness virus (AHSV. These viruses have linear dsRNA genomes divided into ten segments, all of which have previously been assumed to be monocistronic. Results Bioinformatic evidence is presented for a short overlapping coding sequence (CDS in the Orbivirus genome segment 9, overlapping the VP6 cistron in the +1 reading frame. In BTV, a 77–79 codon AUG-initiated open reading frame (hereafter ORFX is present in all 48 segment 9 sequences analysed. The pattern of base variations across the 48-sequence alignment indicates that ORFX is subject to functional constraints at the amino acid level (even when the constraints due to coding in the overlapping VP6 reading frame are taken into account; MLOGD software. In fact the translated ORFX shows greater amino acid conservation than the overlapping region of VP6. The ORFX AUG codon has a strong Kozak context in all 48 sequences. Each has only one or two upstream AUG codons, always in the VP6 reading frame, and (with a single exception always with weak or medium Kozak context. Thus, in BTV, ORFX may be translated via leaky scanning. A long (83–169 codon ORF is present in a corresponding location and reading frame in all other Orbivirus species analysed except Saint Croix River virus (SCRV; the most divergent. Again, the pattern of base variations across sequence alignments indicates multiple coding in the VP6 and ORFX reading frames. Conclusion At ~9.5 kDa, the putative ORFX product in BTV is too small to appear on most published protein gels. Nonetheless, a review of past literature reveals a number of possible detections. We hope that presentation of this bioinformatic analysis will stimulate an attempt to experimentally verify the expression and functional role of ORFX, and hence lead to a greater understanding of the molecular biology of these important

  16. Rotavirus VP6 preparations as a non-replicating vaccine candidates.

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    Jalilvand, Somayeh; Marashi, Sayed Mahdi; Shoja, Zabihollah

    2015-06-26

    Rotavirus (RV) structural proteins VP4 and VP7, located on the surface of viral particles, elicit neutralizing antibodies (Abs) and are therefore considered to be important components of RV vaccines. However, despite inducing neutralizing Abs, limits of cross-neutralizing activity and lack of full correlation with protection limit the usefulness of these proteins as protective agents against RV disease. VP6 protein, which forms the middle layer of RV particles, is discussed as an alternative vaccine candidate since it can induce cross-protective immune responses against different RV strains although the Ab raised is not neutralizing. This report reviews different functions of VP6 that can lead to considering it as an alternative vaccine against RV disease. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Immune responses elicited against rotavirus middle layer protein VP6 inhibit viral replication in vitro and in vivo

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    Lappalainen, Suvi; Pastor, Ana Ruth; Tamminen, Kirsi; López-Guerrero, Vanessa; Esquivel-Guadarrama, Fernando; Palomares, Laura A; Vesikari, Timo; Blazevic, Vesna

    2014-01-01

    Rotavirus (RV) is a common cause of severe gastroenteritis (GE) in children worldwide. Live oral RV vaccines protect against severe RVGE, but the immune correlates of protection are not yet clearly defined. Inner capsid VP6 protein is a highly conserved, abundant, and immunogenic RV protein, and VP6-specific mucosal antibodies, especially IgA, have been implicated to protect against viral challenge in mice. In the present study systemic and mucosal IgG and IgA responses were induced by immunizing BALB/c mice intranasally with a combination of recombinant RV VP6 protein (subgroup II [SGII]) and norovirus (NoV) virus-like particles (VLPs) used in a candidate vaccine. Following immunization mice were challenged orally with murine RV strain EDIMwt (SG non-I-non-II, G3P10[16]). In order to determine neutralizing activity of fecal samples, sera, and vaginal washes (VW) against human Wa RV (SGII, G1P1A[8]) and rhesus RV (SGI, G3P5B[3]), the RV antigen production was measured with an ELISA-based antigen reduction neutralization assay. Only VWs of immunized mice inhibited replication of both RVs, indicating heterotypic protection of induced antibodies. IgA antibody depletion and blocking experiments using recombinant VP6 confirmed that neutralization was mediated by anti-VP6 IgA antibodies. Most importantly, after the RV challenge significant reduction in viral shedding was observed in feces of immunized mice. These results suggest a significant role for mucosal RV VP6-specific IgA for the inhibition of RV replication in vitro and in vivo. In addition, these results underline the importance of non-serotype-specific immunity induced by the conserved subgroup-specific RV antigen VP6 in clearance of RV infection. PMID:25424814

  18. Mice Develop Effective but Delayed Protective Immune Responses When Immunized as Neonates either Intranasally with Nonliving VP6/LT(R192G) or Orally with Live Rhesus Rotavirus Vaccine Candidates

    OpenAIRE

    VanCott, John L.; Prada, Anne E.; McNeal, Monica M.; Stone, Susan C.; Basu, Mitali; Huffer, Bert; Smiley, Kristi L.; Shao, Mingyuan; Bean, Judy A.; Clements, John D.; Choi, Anthony H.-C.; Ward, Richard L.

    2006-01-01

    Rotavirus vaccines are delivered early in life, when the immune system is immature. To determine the effects of immaturity on responses to candidate vaccines, neonatal (7 days old) and adult mice were immunized with single doses of either Escherichia coli-expressed rotavirus VP6 protein and the adjuvant LT(R192G) or live rhesus rotavirus (RRV), and protection against fecal rotavirus shedding following challenge with the murine rotavirus strain EDIM was determined. Neonatal mice immunized intr...

  19. Peptide-Recombinant VP6 Protein Based Enzyme Immunoassay for the Detection of Group A Rotaviruses in Multiple Host Species.

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    Naveen Kumar

    Full Text Available We developed a novel enzyme immunoassay for the detection of group A rotavirus (RVA antigen in fecal samples of multiple host species. The assay is based on the detection of conserved VP6 protein using anti-recombinant VP6 antibodies as capture antibodies and anti-multiple antigenic peptide (identified and constructed from highly immunodominant epitopes within VP6 protein antibodies as detector antibodies. The clinical utility of the assay was evaluated using a panel of 914 diarrhoeic fecal samples from four different host species (bovine, porcine, poultry and human collected from diverse geographical locations in India. Using VP6- based reverse transcription-polymerase chain reaction (RT-PCR as the gold standard, we found that the diagnostic sensitivity (DSn and specificity (DSp of the new assay was high [bovine (DSn = 94.2% & DSp = 100%; porcine (DSn = 94.6% & DSp = 93.3%; poultry (DSn = 74.2% & DSp = 97.7% and human (DSn = 82.1% & DSp = 98.7%]. The concordance with RT-PCR was also high [weighted kappa (k = 0.831-0.956 at 95% CI = 0.711-1.0] as compared to RNA-polyacrylamide gel electrophoresis (RNA-PAGE. The performance characteristics of the new immunoassay were comparable to those of the two commercially available ELISA kits. Our results suggest that this peptide-recombinant protein based assay may serve as a preliminary assay for epidemiological surveillance of RVA antigen and for evaluation of vaccine effectiveness especially in low and middle income settings.

  20. Sequences within the VP6 molecule of bluetongue virus that determine cytoplasmic and nuclear targeting of the protein.

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    Yi, C K; Bansal, O B; Hong, M L; Chatterjee, S.; Roy, P

    1996-01-01

    Genome segment 9 of bluetongue virus serotype 10 encodes the minor protein VP6. The protein is abundant with basic residues particularly in two regions of the carboxy half of the molecule. A series of amino- and carboxy-terminal deletion mutants was expressed in mammalian cells by using a vaccinia virus T7 polymerase-driven transient expression system, and the intracellular fate of the products was monitored by both immunofluorescence staining and cell fractionation techniques. Data obtained ...

  1. Use of recombinant rotavirus VP6 nanotubes as a multifunctional template for the synthesis of nanobiomaterials functionalized with metals.

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    Plascencia-Villa, Germán; Saniger, José M; Ascencio, Jorge A; Palomares, Laura A; Ramírez, Octavio T

    2009-12-01

    The structural characteristics and predefined constant size and shape of viral assemblies make them useful tools for nanobiotechnology, in particular as scaffolds for constructing highly organized novel nanomaterials. In this work it is shown for the first time that nanotubes formed by recombinant rotavirus VP6 protein can be used as scaffolds for the synthesis of hybrid nanocomposites. Rotavirus VP6 was produced by the insect cell-baculovirus expression vector system. Nanotubes of several micrometers in length and various diameters in the nanometer range were functionalized with Ag, Au, Pt, and Pd through strong (sodium borohydride) or mild (sodium citrate) chemical reduction. The nanocomposites obtained were characterized by transmission electron microscopy (TEM), high-resolution TEM (HRTEM) with energy dispersive spectroscopy (EDS), dynamic light scattering, and their characteristic plasmon resonance. The outer surface of VP6 nanotubes had intrinsic affinity to metal deposition that allowed in situ synthesis of nanoparticles. Furthermore, the use of preassembled recombinant protein structures resulted in highly ordered integrated materials. It was possible to obtain different extents and characteristics of the metal coverage by manipulating the reaction conditions. TEM revealed either a continuous coverage with an electrodense thin film when using sodium citrate as reductant or a discrete coverage with well-dispersed metal nanoparticles of diameters between 2 and 9 nm when using sodium borohydride and short reaction times. At long reaction times and using sodium borohydride, the metal nanoparticles coalesced and resulted in a thick metal layer. HRTEM-EDS confirmed the identity of the metal nanoparticles. Compared to other non-recombinant viral scaffolds used until now, the recombinant VP6 nanotubes employed here have important advantages, including a longer axial dimension, a dynamic multifunctional hollow structure, and the possibility of producing them

  2. Sequences within the VP6 molecule of bluetongue virus that determine cytoplasmic and nuclear targeting of the protein.

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    Yi, C K; Bansal, O B; Hong, M L; Chatterjee, S; Roy, P

    1996-07-01

    Genome segment 9 of bluetongue virus serotype 10 encodes the minor protein VP6. The protein is abundant with basic residues particularly in two regions of the carboxy half of the molecule. A series of amino- and carboxy-terminal deletion mutants was expressed in mammalian cells by using a vaccinia virus T7 polymerase-driven transient expression system, and the intracellular fate of the products was monitored by both immunofluorescence staining and cell fractionation techniques. Data obtained indicated clearly that VP6 has nuclear transportation signals which may be correlated with positively charged domains of the molecule. In the intact molecule, though, these signals are masked and the protein is retained in the cytoplasm. The biochemical and immunofluorescence data obtained indicate that sequences in the region of residues 33 to 80 of the 328-amino acid protein are required for the retention of VP6 within the cell cytoplasm while amino acids 303 to 308 in the carboxy-terminal half of the molecule appear to possess nuclear localization capabilities.

  3. LA PROTEÍNA VIRAL VP6 DE ROTAVIRUS COINMUNOPRECIPITA CON HSC70 EN CÉLULAS MA104 The viral protein VP6 of rotavirus coinmunoprecipated with HSC70 in cels MA104

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    Luz Stella Rodríguez

    2006-03-01

    Full Text Available Introducción: los rotavirus son la principal causa de gastroenteritis en niños menores de cinco años. Hasta el momento se desconoce cómo entran estos virus a la célula huésped. La proteína de choque térmico, HSC70 se ha visto involucrada en la entrada del virus, sin embargo no se han relacionado bien todos los sitios de unión entre las proteínas virales del rotavirus y la HSC70. Objetivos: el propósito de este trabajo fue determinar cuáles proteínas virales del rotavirus son responsables de la unión de la proteína de choque térmico, HSC70. Material y métodos: se realizaron ensayos de coinmunoprecipitación utilizando lisados de células infectadas así como proteínas virales recombinantes. Estos ensayos se revelaron mediante SDS-PAGE y Western blot utilizando anticuerpos policlonales que reconocen las proteínas del rotavirus. Resultados. En los experimentos realizados se encontró que la proteína viral VP6 coinmunoprecipita con HSC70 en las células MA104 durante la infección con rotavirus. La VP6, producida con vaccinia recombinante en MA104, también coinmunoprecipitó con HSC70. Conclusión. La proteína VP6 de rotavirus interacciona con la proteína HSC70 en lisados de células MA104 infectadas con rotavirus. La unión de la VP6 recombinante a la HSC70 sugiere que la interacción de estas proteínas es independiente de otras proteínas virales.Introduction: Rotaviruses are the main cause of gastroenteritis in children under five years old. At this moment is unknown how these viruses entry to host cell. The heat shock cognate protein HSC70 has been involved in rotavirus cell entry. However, the relationship between rotavirus proteins and HSC70 has not been established. Objectives: the purpose of this work was to determine wich rotaviruses proteins interact with HSC70. Material and methods: coimmunoprecipitation assays were done on a rotavirus infected supernatant and recombinant viral proteins. These assays were revealed

  4. Identification of Rotavirus VP6-Specific CD4+ T Cell Epitopes in a G1P[8] Human Rotavirus-Infected Rhesus Macaque

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    Wei Zhao

    2008-01-01

    Full Text Available A non-human primate model was used to evaluate its potential for identification of rotavirus viral protein 6 (VP6 CD4+ T cell epitopes. Four juvenile rhesus macaques were inoculated with a mixed inoculum (G1P[8] and G9P[8] of human rotaviruses. Infection accompanied by G1P[8] shedding was achieved in the two macaques that had no rotavirus immunoglobulin A (IgA in plasma. To measure the interferon gamma (IFN-γ and tumor necrosis factor (TNF anti-viral cytokines produced by peripheral CD4+ cells that recognize VP6 epitopes, whole blood cells from one infected macaque were stimulated in vitro with VP6 peptides. Stimulation with peptide pools derived from the simian rotavirus VP6 161–395 region revealed reactivity of CD4+ T cells with the VP6 281–331 domain. A VP6 301–315 region was identified as the epitope responsible for IFN-γ production while a broader VP6 293–327 domain was linked to TNF production. These results suggest that human rotavirus-infected macaques can be used for identification of additional epitopes and domains to address specific questions related to the development of pediatric vaccines.

  5. Expresión en cultivo celular de la proteína VP6 de rotavirus mediante el uso de vectores virales basados en HSV-1

    OpenAIRE

    Carlos A. Palacios; Claus, Juan; Mattion, Nora

    2016-01-01

    HSV-1 vectors were developed for the expression of several rotavirus genes. Genes from other pathogens were also expressed, thus generating a set of tools to be tested as new vaccine candidates against In this section, we show two different HSV-1 vectors that express the VP6 protein from different rotavirus strains. Figure 1 shows a defective recombinant virus expressing simultaneously EGFP and VP6 from murine rotavirus strain EC, In Figure 2, an amplicon vector overexpressing VP6 from a Wa s...

  6. Development of primers for sequencing the NSP1, NSP3, and VP6 genes of the group A porcine rotavirus

    Directory of Open Access Journals (Sweden)

    Fernanda Dornelas Florentino Silva

    2014-02-01

    Full Text Available Rotavirus is the causative pathogen of diarrhea in humans and in several animal species. Eight pairs of primers were developed and used for Sanger sequencing of the coding region of the NSP1, NSP3, and VP6 genes based on the conserved regions of the genome of the group A porcine rotavirus. Three samples previously screened as positive for group A rotaviruses were subjected to gene amplification and sequencing to characterize the pathogen. The information generated from this study is crucial for the understanding of the epidemiology of the disease.

  7. Mice develop effective but delayed protective immune responses when immunized as neonates either intranasally with nonliving VP6/LT(R192G) or orally with live rhesus rotavirus vaccine candidates.

    Science.gov (United States)

    VanCott, John L; Prada, Anne E; McNeal, Monica M; Stone, Susan C; Basu, Mitali; Huffer, Bert; Smiley, Kristi L; Shao, Mingyuan; Bean, Judy A; Clements, John D; Choi, Anthony H-C; Ward, Richard L

    2006-05-01

    Rotavirus vaccines are delivered early in life, when the immune system is immature. To determine the effects of immaturity on responses to candidate vaccines, neonatal (7 days old) and adult mice were immunized with single doses of either Escherichia coli-expressed rotavirus VP6 protein and the adjuvant LT(R192G) or live rhesus rotavirus (RRV), and protection against fecal rotavirus shedding following challenge with the murine rotavirus strain EDIM was determined. Neonatal mice immunized intranasally with VP6/LT(R192G) were unprotected at 10 days postimmunization (dpi) and had no detectable rotavirus B-cell (antibody) or CD4(+) CD8(+) T-cell (rotavirus-inducible, Th1 [gamma interferon and interleukin-2 {IL-2}]-, Th2 [IL-5 and IL-4]-, or ThIL-17 [IL-17]-producing spleen cells) responses. However, by 28 and 42 dpi, these mice were significantly (P >or= 0.003) protected and contained memory rotavirus-specific T cells but produced no rotavirus antibody. In contrast, adult mice were nearly fully protected by 10 dpi and contained both rotavirus immunoglobulin G and memory T cells. Neonates immunized orally with RRV were also less protected (P=0.01) than adult mice by 10 dpi and produced correspondingly less rotavirus antibody. Both groups contained few rotavirus-specific memory T cells. Protection levels by 28 dpi for neonates or adults were equal, as were rotavirus antibody levels. This report introduces a neonatal mouse model for active protection studies with rotavirus vaccines. It indicates that, with time, neonatal mice develop full protection after intranasal immunization with VP6/LT(R192G) or oral immunization with a live heterologous rotavirus and supports reports that protection depends on CD4(+) T cells or antibody, respectively.

  8. Video coding standards AVS China, H.264/MPEG-4 PART 10, HEVC, VP6, DIRAC and VC-1

    CERN Document Server

    Rao, K R; Hwang, Jae Jeong

    2014-01-01

    Review by Ashraf A. Kassim, Professor, Department of Electrical & Computer Engineering, and Associate Dean, School of Engineering, National University of Singapore.     The book consists of eight chapters of which the first two provide an overview of various video & image coding standards, and video formats. The next four chapters present in detail the Audio & video standard (AVS) of China, the H.264/MPEG-4 Advanced video coding (AVC) standard, High efficiency video coding (HEVC) standard and the VP6 video coding standard (now VP10) respectively. The performance of the wavelet based Dirac video codec is compared with H.264/MPEG-4 AVC in chapter 7. Finally in chapter 8, the VC-1 video coding standard is presented together with VC-2 which is based on the intra frame coding of Dirac and an outline of a H.264/AVC to VC-1 transcoder.   The authors also present and discuss relevant research literature such as those which document improved methods & techniques, and also point to other related reso...

  9. Comparison of two eukaryotic systems for the expression of VP6 protein of rotavirus specie A: transient gene expression in HEK293-T cells and insect cell-baculovirus system.

    Science.gov (United States)

    da Silva Junior, Haroldo Cid; da Silva E Mouta Junior, Sérgio; de Mendonça, Marcos César Lima; de Souza Pereira, Mirian Claudia; da Rocha Nogueira, Alanderson; de Azevedo, Maria Luiza Borges; Leite, José Paulo Gagliardi; de Moraes, Márcia Terezinha Baroni

    2012-09-01

    The VP6 protein of rotavirus A (RVA) is a target antigen used for diagnostic assays and also for the development of new RVA vaccines. We have compared the expression of VP6 protein in human embryonic kidney (HEK293-T) cells with results obtained using a well-established insect cell-baculovirus system. The recombinant VP6 (rVP6) expressed in HEK293-T cells did not present degradation and also retained the ability to form trimers. In the insect cell-baculovirus system, rVP6 was expressed at higher levels and with protein degradation as well as partial loss of ability to form trimers was observed. Therefore, HEK293-T cells represent a less laborious alternative system than insect cells for expression of rVP6 from human RVA.

  10. Oral Administration of a Seed-based Bivalent Rotavirus Vaccine Containing VP6 and NSP4 Induces Specific Immune Responses in Mice

    Directory of Open Access Journals (Sweden)

    Hao Feng

    2017-05-01

    Full Text Available Rotavirus is the leading cause of severe diarrheal disease among newborns. Plant-based rotavirus vaccines have been developed in recent years and have been proven to be effective in animal models. In the present study, we report a bivalent vaccine candidate expressing rotavirus subunits VP6 and NSP4 fused with the adjuvant subunit B of E. coli heat-labile enterotoxin (LTB in maize seeds. The RT-PCR and Western blot results showed that VP6 and LTB-NSP4 antigens were expressed and accumulated in maize seeds. The expression levels were as high as 0.35 and 0.20% of the total soluble protein for VP6 and LTB-NSP4, respectively. Oral administration of transgenic maize seeds successfully stimulated systemic and mucosal responses, with high titers of serum IgG and mucosal IgA antibodies, even after long-term storage. This study is the first to use maize seeds as efficient generators for the development of a bivalent vaccine against rotavirus.

  11. Oral Administration of a Seed-based Bivalent Rotavirus Vaccine Containing VP6 and NSP4 Induces Specific Immune Responses in Mice

    Science.gov (United States)

    Feng, Hao; Li, Xin; Song, Weibin; Duan, Mei; Chen, Hong; Wang, Tao; Dong, Jiangli

    2017-01-01

    Rotavirus is the leading cause of severe diarrheal disease among newborns. Plant-based rotavirus vaccines have been developed in recent years and have been proven to be effective in animal models. In the present study, we report a bivalent vaccine candidate expressing rotavirus subunits VP6 and NSP4 fused with the adjuvant subunit B of E. coli heat-labile enterotoxin (LTB) in maize seeds. The RT-PCR and Western blot results showed that VP6 and LTB-NSP4 antigens were expressed and accumulated in maize seeds. The expression levels were as high as 0.35 and 0.20% of the total soluble protein for VP6 and LTB-NSP4, respectively. Oral administration of transgenic maize seeds successfully stimulated systemic and mucosal responses, with high titers of serum IgG and mucosal IgA antibodies, even after long-term storage. This study is the first to use maize seeds as efficient generators for the development of a bivalent vaccine against rotavirus. PMID:28620404

  12. Baby Steps: Learn the Signs. Act Early.

    Centers for Disease Control (CDC) Podcasts

    2008-09-22

    CDC recognized the impact of developmental disabilities and invested in a campaign to help parents measure their children's progress by monitoring how they play, learn, speak, and act. .  Created: 9/22/2008 by National Center on Birth Defects and Developmental Disabilities, Division of Human Development and Disability, Child Development Studies Team.   Date Released: 9/23/2008.

  13. [Use of the recombinant baculovirus BacVP6C for the construction of an internal positive control of rotavirus C].

    Science.gov (United States)

    Abid-Ayadi, I; Guix, S; Pintó, R M; Bosch, A

    2011-06-01

    Unlike group A, a few studies have interested other groups of the rotavirus, especially in Tunisia. The role of rotavirus C (RVC) infection is underestimated because of its sporadic nature. The aim of our study was to develop rapid diagnostic procedures of RVC by using an internal positive control of reverse transcription PCR (RT-PCR). The internal positive control (386pb) was designed from the recombinant baculovirus BacVP6C containing the full length cDNA of the Cowden strain gene 5 (1353pb). A fragment of 596pb was amplified by PCR using the BacVP6C DNA ds as template. Then, a central part of 210pb was deleted and the remaining fragment (386pb) was cloned into pGEM-3Zf(+) plasmid between SP6 and T7 RNA polymerase promoters. The obtained recombinant plasmid "pIAM1" was then used for the generation of the internal positive control by in vitro transcription. The sensibility of the RT-PCR was about 3.66×10(5) molecules of RNA/μl. The use of a shorter positive control, as compared to the wild type, allows increased specificity of the RT-PCR reaction, and could be used for efficient diagnostic and surveillance of RVC-caused diseases. Copyright © 2009 Elsevier Masson SAS. All rights reserved.

  14. Re-reading early modern prayer as social act

    DEFF Research Database (Denmark)

    Sterrett, Joseph William

    2013-01-01

    Literary criticism is increasingly interested in prayer as a cultural and literary mode. This article proposes a theoretical framework for reading prayer as a performance, as an act governed by community conventions with effects in the social world. Drawing upon groundbreaking work by Marcel Mauss...

  15. Early endocrine disruptors exposure acts on 3T3-L1 differentiation and endocrine activity

    Directory of Open Access Journals (Sweden)

    Sofiane Boudalia

    2017-06-01

    Conclusion: This study confirms that EDs singularly or in mixtures, introduced during early stages of life, could affect the differentiation and the endocrine activity of adipocytes, and can act as potential factors for obesity.

  16. Early testimonial learning: monitoring speech acts and speakers.

    Science.gov (United States)

    Stephens, Elizabeth; Suarez, Sarah; Koenig, Melissa

    2015-01-01

    Testimony provides children with a rich source of knowledge about the world and the people in it. However, testimony is not guaranteed to be veridical, and speakers vary greatly in both knowledge and intent. In this chapter, we argue that children encounter two primary types of conflicts when learning from speakers: conflicts of knowledge and conflicts of interest. We review recent research on children's selective trust in testimony and propose two distinct mechanisms supporting early epistemic vigilance in response to the conflicts associated with speakers. The first section of the chapter focuses on the mechanism of coherence checking, which occurs during the process of message comprehension and facilitates children's comparison of information communicated through testimony to their prior knowledge, alerting them to inaccurate, inconsistent, irrational, and implausible messages. The second section focuses on source-monitoring processes. When children lack relevant prior knowledge with which to evaluate testimonial messages, they monitor speakers themselves for evidence of competence and morality, attending to cues such as confidence, consensus, access to information, prosocial and antisocial behavior, and group membership. © 2015 Elsevier Inc. All rights reserved.

  17. Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria

    DEFF Research Database (Denmark)

    Abdulla, S.; Adam, I.; Adjei, G. O.

    2015-01-01

    early parasitological response were investigated using logistic regression with study sites fitted as a random effect. The risk of bias in included studies was evaluated based on study design, methodology and missing data. Results: In total, 29,493 patients from 84 clinical trials were included.......020, compared to dihydroartemisinin-piperaquine). Conclusions: The three ACTs assessed in this analysis continue to achieve rapid early parasitological clearance across the sites assessed in Sub-Saharan Africa. A threshold of 5 % day 3 parasite positivity from a minimum sample size of 50 patients provides...

  18. Early and parallel processing of pragmatic and semantic information in speech acts: neurophysiological evidence.

    Science.gov (United States)

    Egorova, Natalia; Shtyrov, Yury; Pulvermüller, Friedemann

    2013-01-01

    Although language is a tool for communication, most research in the neuroscience of language has focused on studying words and sentences, while little is known about the brain mechanisms of speech acts, or communicative functions, for which words and sentences are used as tools. Here the neural processing of two types of speech acts, Naming and Requesting, was addressed using the time-resolved event-related potential (ERP) technique. The brain responses for Naming and Request diverged as early as ~120 ms after the onset of the critical words, at the same time as, or even before, the earliest brain manifestations of semantic word properties could be detected. Request-evoked potentials were generally larger in amplitude than those for Naming. The use of identical words in closely matched settings for both speech acts rules out explanation of the difference in terms of phonological, lexical, semantic properties, or word expectancy. The cortical sources underlying the ERP enhancement for Requests were found in the fronto-central cortex, consistent with the activation of action knowledge, as well as in the right temporo-parietal junction (TPJ), possibly reflecting additional implications of speech acts for social interaction and theory of mind. These results provide the first evidence for surprisingly early access to pragmatic and social interactive knowledge, which possibly occurs in parallel with other types of linguistic processing, and thus supports the near-simultaneous access to different subtypes of psycholinguistic information.

  19. Early and parallel processing of pragmatic and semantic information in speech acts: neurophysiological evidence

    Directory of Open Access Journals (Sweden)

    Natalia eEgorova

    2013-03-01

    Full Text Available Although language is a tool for communication, most research in the neuroscience of language has focused on studying words and sentences, while little is known about the brain mechanisms of speech acts, or communicative functions, for which words and sentences are used as tools. Here the neural processing of two types of speech acts, Naming and Requesting, was addressed using the time-resolved event-related potential (ERP technique. The brain responses for Naming and Request diverged as early as ~120 ms after the onset of the critical words, at the same time as, or even before, the earliest brain manifestations of semantic word properties could be detected. Request-evoked potentials were generally larger in amplitude than those for Naming. The use of identical words in closely matched settings for both speech acts rules out explanation of the difference in terms of phonological, lexical, semantic properties or word expectancy. The cortical sources underlying the ERP enhancement for Requests were found in the fronto-central cortex, consistent with the activation of action knowledge, as well as in right temporo-parietal junction, possibly reflecting additional implications of speech acts for social interaction and theory of mind. These results provide the first evidence for surprisingly early access to pragmatic and social interactive knowledge, which possibly occurs in parallel with other types of linguistic processing, and thus supports the near-simultaneous access to different subtypes of psycholinguistic information.

  20. Surviving the Lunacy Act of 1890: English Psychiatrists and Professional Development during the Early Twentieth Century.

    Science.gov (United States)

    Takabayashi, Akinobu

    2017-04-01

    In recent decades, historians of English psychiatry have shifted their major concerns away from asylums and psychiatrists in the nineteenth century. This is also seen in the studies of twentieth-century psychiatry where historians have debated the rise of psychology, eugenics and community care. This shift in interest, however, does not indicate that English psychiatrists became passive and unimportant actors in the last century. In fact, they promoted Lunacy Law reform for a less asylum-dependent mode of psychiatry, with a strong emphasis on professional development. This paper illustrates the historical dynamics around the professional development of English psychiatry by employing Andrew Abbott's concept of professional development. Abbott redefines professional development as arising from both abstraction of professional knowledge and competition regarding professional jurisdiction. A profession, he suggests, develops through continuous re-formation of its occupational structure, mode of practice and political language in competing with other professional and non-professional forces. In early twentieth-century England, psychiatrists promoted professional development by framing political discourse, conducting a daily trade and promoting new legislation to defend their professional jurisdiction. This professional development story began with the Lunacy Act of 1890, which caused a professional crisis in psychiatry and led to inter-professional competition with non-psychiatric medical service providers. To this end, psychiatrists devised a new political rhetoric, 'early treatment of mental disorder', in their professional interests and succeeded in enacting the Mental Treatment Act of 1930, which re-instated psychiatrists as masters of English psychiatry.

  1. CHLOROPLAST BIOGENESIS Genes Act Cell and Noncell Autonomously in Early Chloroplast Development1

    Science.gov (United States)

    de la Luz Gutiérrez-Nava, María; Gillmor, C. Stewart; Jiménez, Luis F.; Guevara-García, Arturo; León, Patricia

    2004-01-01

    In order to identify nuclear genes required for early chloroplast development, a collection of photosynthetic pigment mutants of Arabidopsis was assembled and screened for lines with extremely low levels of chlorophyll. Nine chloroplast biogenesis (clb) mutants that affect proplastid growth and thylakoid membrane formation and result in an albino seedling phenotype were identified. These mutations identify six new genes as well as a novel allele of cla1. clb mutants have less than 2% of wild-type chlorophyll levels, and little or no expression of nuclear and plastid-encoded genes required for chloroplast development and function. In all but one mutant, proplastids do not differentiate enough to form elongated stroma thylakoid membranes. Analysis of mutants during embryogenesis allows differentiation between CLB genes that act noncell autonomously, where partial maternal complementation of chloroplast development is observed in embryos, and those that act cell autonomously, where complementation during embryogenesis is not observed. Molecular characterization of the noncell autonomous clb4 mutant established that the CLB4 gene encodes for hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase (HDS), the next to the last enzyme of the methylerythritol 4-phosphate (MEP) pathway for the synthesis of plastidic isoprenoids. The noncell autonomous nature of the clb4 mutant suggests that products of the MEP pathway can travel between tissues, and provides in vivo evidence that some movement of MEP intermediates exists from the cytoplasm to the plastid. The isolation and characterization of clb mutants represents the first systematic study of genes required for early chloroplast development in Arabidopsis. PMID:15133149

  2. An early look at changes in employer-sponsored insurance under the Affordable Care Act.

    Science.gov (United States)

    Blavin, Fredric; Shartzer, Adele; Long, Sharon K; Holahan, John

    2015-01-01

    Critics frequently characterize the Affordable Care Act (ACA) as a threat to the survival of employer-sponsored insurance. The Medicaid expansion and Marketplace subsidies could adversely affect employers' incentives to offer health insurance and workers' incentives to take up such offers. This article takes advantage of timely data from the Health Reform Monitoring Survey for June 2013 through September 2014 to examine, from the perspective of workers, early changes in offer, take-up, and coverage rates for employer-sponsored insurance under the ACA. We found no evidence that any of these rates have declined under the ACA. They have, in fact, remained constant: around 82 percent, 86 percent, and 71 percent, respectively, for all workers and around 63 percent, 71 percent, and 45 percent, respectively, for low-income workers. To date, the ACA has had no effect on employer coverage. Economic incentives for workers to obtain coverage from employers remain strong. Project HOPE—The People-to-People Health Foundation, Inc.

  3. Media Messages and Perceptions of the Affordable Care Act during the Early Phase of Implementation.

    Science.gov (United States)

    Fowler, Erika Franklin; Baum, Laura M; Barry, Colleen L; Niederdeppe, Jeff; Gollust, Sarah E

    2017-02-01

    Public opinion about the Affordable Care Act (ACA) has been polarized since the law's passage. Past research suggests these conditions would make any media influence on the public limited at best. However, during the early phase of implementation, locally broadcast ACA-related media messages-in the form of paid health insurance and political advertisements and news media stories-abounded as advocates, insurance marketers, and politicians sought to shape the public's perceptions of the law. To what extent did message exposure affect ACA perceptions during the first open enrollment period? We merge data on volumes of messaging at the media market level with nationally representative survey data to examine the relationship between estimated exposure to media messaging and the public's perceptions of how informed they were about and favorable toward the ACA in October 2013. We find that higher volumes of insurance advertising and local news coverage are associated with participants' perceptions of being informed about the law. Volumes of insurance advertising and of local news coverage are also associated with participants' favorability toward the law, but the relationship varies with partisanship, supporting the growing body of research describing partisan perceptual bias. Copyright © 2017 by Duke University Press.

  4. Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria

    DEFF Research Database (Denmark)

    Abdulla, S.; Adam, I.; Adjei, G. O.

    2015-01-01

    trials and randomized controlled trials), including ACTs conducted in Sub-Saharan Africa, between 1960 and 2012. Individual patient data from these studies were shared with the WorldWide Antimalarial Resistance Network (WWARN) and pooled using an a priori statistical analytical plan. Factors affecting...

  5. Breaking the addition addiction: creating the conditions for knowing-to act in early algebra

    OpenAIRE

    Molina, Marta; Ambrose, Rebecca; Castro, Encarnaci??n; Castro, Enrique

    2009-01-01

    We use data from a teaching experiment with a group of eight years old students to explore the potential of examining number sentences to promote relational thinking. This type of thinking requires attention to mathematical structure through consideration of relationships between terms contained in the sentence and not just on computation and comparison of the numeric values of each side. We show that children came to ???know-to act??? in the context of written activities and orchestrated dis...

  6. Affordable Care Act Changes To Medicare Led To Increased Diagnoses Of Early-Stage Colorectal Cancer Among Seniors.

    Science.gov (United States)

    Lissenden, Brett; Yao, Nengliang Aaron

    2017-01-01

    The Affordable Care Act (ACA) helped make preventive care, including recommended cancer screening, more affordable and accessible for millions of Americans. Using population-based data from the Surveillance, Epidemiology, and End Results (SEER) Program, we estimated the impact of ACA policy changes to facilitate the diagnosis of cancer at an earlier and more treatable stage. We estimated that the ACA resulted in an increase of 8,400 (8 percent) diagnoses of early-stage colorectal cancer among US seniors in the period 2011-13. However, the ACA had no distinguishable effect on the number of diagnoses of early-stage breast cancer over the same time period. It is likely that the ACA initially affected the diagnosis of colorectal cancer more than that of breast cancer because the decrease in out-of-pocket spending was larger for colorectal than for breast cancer screening. Project HOPE—The People-to-People Health Foundation, Inc.

  7. Promoting Early Career Teacher Resilience: A Framework for Understanding and Acting

    Science.gov (United States)

    Johnson, Bruce; Down, Barry; Le Cornu, Rosie; Peters, Judy; Sullivan, Anna; Pearce, Jane; Hunter, Janet

    2014-01-01

    In this paper, we undertake a brief review of the "conventional" research into the problems of early career teachers to create a juxtaposed position from which to launch an alternative approach based on resilience theory. We outline four reasons why a new contextualised, social theory of resilience has the potential to open up the field…

  8. Early virologic responses and hematologic safety of direct-acting antiviral therapies in veterans with chronic hepatitis C.

    Science.gov (United States)

    Belperio, Pamela S; Hwang, Elizabeth W; Thomas, I Chun; Mole, Larry A; Cheung, Ramsey C; Backus, Lisa I

    2013-08-01

    There are limited data on the early effectiveness of direct-acting antiviral (DAA) therapies for patients with hepatitis C virus (HCV) infection in routine medical practice. We aimed to evaluate real-world experience with DAA-based regimens. By using the Veterans Affairs' Clinical Case Registry, we conducted a prospective observational intent-to-treat analysis of veterans infected with HCV genotype 1 who began treatment with pegylated interferon, ribavirin, and boceprevir (BOC, n = 661) or telaprevir (TVR, n = 198) before January 2012. We determined rates of virologic response at treatment weeks 4, 8, 12, and 24; futility; early discontinuation; and adverse hematologic events. About one third of patients discontinued treatment by week 24 (30% BOC, 34% TVR). A higher percentage of treatment-naive, noncirrhotic patients receiving BOC had undetectable levels of virus at week 24 than patients receiving TVR (74% vs 60%; P = .03). There were no significant differences in rates of early response within subgroups of cirrhotic patients, prior relapsers, prior partial responders, or prior null responders. By week 24, treatment was determined to be futile for 14% of patients receiving BOC and 17% of those receiving TVR. No differences were observed in overall rates of anemia (50% BOC, 49% TVR) or thrombocytopenia (16% BOC, 18% TVR); higher rates of neutropenia were observed in BOC-treated patients (34% BOC, 21% TVR; P = .008). HCV-infected veterans treated in routine medical practice with DAA-based regimens (BOC or TVR) had rates of early response comparable with those reported in clinical trials. However, they had higher rates of futility and early discontinuation than clinical trial participants. Further studies are needed to determine rates of sustained viral response. Copyright © 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.

  9. Self-sterility in two Cytisus species (Leguminosae, Papilionoideae) due to early-acting inbreeding depression.

    Science.gov (United States)

    Valtueña, Francisco J; Rodríguez-Riaño, Tomás; Espinosa, Francisco; Ortega-Olivencia, Ana

    2010-01-01

    In most angiosperms, the endosperm develops before the embryo, but with harmony between the two structures until final seed formation. In an embryological study, we show that inbreeding depression causes disharmony in development of the two structures in two Leguminosae shrubs, Cytisus multiflorus and C. striatus. Our main objective was to test the causes of self-sterility in the two species by comparing the embryological development of the self seeds with that of cross seeds. In developing selfed seeds of C. multiflorus, the embryo reaches at most the globular stage and never forms mature seeds, while in C. striatus a few mature selfed seeds are formed. In both species, the main cause of abortion of developing selfed seeds is diminished endosperm development (low values of the ratio of endosperm to embryo), which triggers collapse of the endosperm and embryo. The results indicate that self-sterility in C. striatus is postzygotic because of strong, early inbreeding depression, while in C. multiflorus there exists a mixed pre- and postzygotic mechanism; the prezygotic mechanism causes rejection of some self-pollen tubes in the style/ovary, and the early inbreeding depression triggers abortion of fertilized ovules that escaped that action.

  10. Diffusion of subsidized ACTs in accredited drug shops in Tanzania: determinants of stocking and characteristics of early and late adopters.

    Science.gov (United States)

    Larson, Peter S; Yadav, Prashant; Alphs, Sarah; Arkedis, Jean; Massaga, Julius; Sabot, Oliver; Cohen, Jessica L

    2013-12-18

    Many households in sub-Saharan Africa utilize the private sector as a primary source of treatment for malaria episodes. Expanding access to effective treatment in private drug shops may help reduce incidence of severe disease and mortality. This research leveraged a longitudinal survey of stocking of subsidized artemisinin combination therapies (ACTs), an effective anti-malarial, in Accredited Drug Dispensing Outlets (ADDOs) in two regions of Tanzania. This provided a unique opportunity to explore shop and market level determinants of product diffusion in a developing country retail market. 356 ADDOs in the Rukwa and Mtwara regions of Tanzania were surveyed at seven points between Feb 2011 and May 2012. Shop level audits were used to measure the availability of subsidized ACTs at each shop. Data on market and shop level factors were collected during the survey and also extracted from GIS layers. Regression and network based methodologies were used. Shops classified as early and late adopters, following Rogers' model of product diffusion, were compared. The Bass model of product diffusion was applied to determine whether shops stocked ACTs out of a need to imitate market competitors or a desire to satisfy customer needs. Following the introduction of a subsidy for ACTs, stocking increased from 12% to nearly 80% over the seven survey rounds. Stocking was influenced by higher numbers of proximal shops and clinics, larger customer traffic and the presence of a licensed pharmacist. Early adopters were characterized by a larger percentage of customers seeking care for malaria, a larger catchment and sourcing from specific wholesalers/suppliers. The Bass model of product diffusion indicated that shops were adopting products in response to competitor behavior, rather than customer demand. Decisions to stock new pharmaceutical products in Tanzanian ADDOs are influenced by a combination of factors related to both market competition and customer demand, but are particularly

  11. The Early-Acting Peroxin PEX19 Is Redundantly Encoded, Farnesylated, and Essential for Viability in Arabidopsis thaliana.

    Directory of Open Access Journals (Sweden)

    Margaret M McDonnell

    Full Text Available Peroxisomes are single-membrane bound organelles that are essential for normal development in plants and animals. In mammals and yeast, the peroxin (PEX proteins PEX3 and PEX19 facilitate the early steps of peroxisome membrane protein (PMP insertion and pre-peroxisome budding from the endoplasmic reticulum. The PEX3 membrane protein acts as a docking site for PEX19, a cytosolic chaperone for PMPs that delivers PMPs to the endoplasmic reticulum or peroxisomal membrane. PEX19 is farnesylated in yeast and mammals, and we used immunoblotting with prenylation mutants to show that PEX19 also is fully farnesylated in wild-type Arabidopsis thaliana plants. We examined insertional alleles disrupting either of the two Arabidopsis PEX19 isoforms, PEX19A or PEX19B, and detected similar levels of PEX19 protein in the pex19a-1 mutant and wild type; however, PEX19 protein was nearly undetectable in the pex19b-1 mutant. Despite the reduction in PEX19 levels in pex19b-1, both pex19a-1 and pex19b-1 single mutants lacked notable peroxisomal β-oxidation defects and displayed normal levels and localization of peroxisomal matrix and membrane proteins. The pex19a-1 pex19b-1 double mutant was embryo lethal, indicating a redundantly encoded critical role for PEX19 during embryogenesis. Expressing YFP-tagged versions of either PEX19 isoform rescued this lethality, confirming that PEX19A and PEX19B act redundantly in Arabidopsis. We observed that pex19b-1 enhanced peroxisome-related defects of a subset of peroxin-defective mutants, supporting a role for PEX19 in peroxisome function. Together, our data indicate that Arabidopsis PEX19 promotes peroxisome function and is essential for viability.

  12. Early Impact of the Affordable Care Act on Insurance Among Young Adults with Cancer: Analysis of the Dependent Insurance Provision

    Science.gov (United States)

    Parsons, Helen M.; Schmidt, Susanne; Tenner, Laura L.; Bang, Heejung; Keegan, Theresa H.M.

    2016-01-01

    Background The Affordable Care Act (ACA) included provisions to extend dependent healthcare coverage up to the age of 26 years in 2010. We examined the early impact of the ACA (prior to implementation of insurance exchanges in 2014) on insurance rates in young adults with cancer, a historically underinsured group. Methods Using National Cancer Institute Surveillance, Epidemiology and End Results (SEER) data for 18 cancer registries, we examined insurance rates pre-(January 2007–September 2010) vs. post-(October 2010–December 2012) dependent insurance provisions among young adults aged 18–29 years when diagnosed with cancer during 2007–2012. Using multivariate generalized mixed effect models, we conducted difference-in-differences analysis to examine changes in overall and Medicaid insurance after the ACA among young adults eligible (18–25 years) and ineligible (26–29 years) for policy changes. Results Among 39,632 young adult cancer survivors, we found an increase in overall insurance rates in 18–25 year-olds after the dependent provisions (83.5% pre vs. 85.4% post, pinsured relative to 26–29 year-olds (pinsurance rates for young adults 18–25 relative to those 26–29 (1.9% vs. −0.5%) that were not due to increases in Medicaid enrollment, demonstrating a positive impact of the ACA dependent care provisions on insurance rates in this population. PMID:26998967

  13. Early Intervention and Maltreated Children: A Current Look at the Child Abuse Prevention and Treatment Act and Part C

    Science.gov (United States)

    Moxley, Kathleen M.; Squires, Jane; Lindstrom, Lauren

    2012-01-01

    Current literature regarding the prevalence of child abuse and neglect, resulting developmental impacts on children, and early intervention services for children and families involved in the child welfare system is summarized. While early intervention eligibility referrals are mandated for this population under the Child Abuse Prevention and…

  14. Significant adverse reactions to long-acting gonadotropin-releasing hormone agonists for the treatment of central precocious puberty and early onset puberty

    Directory of Open Access Journals (Sweden)

    Ji Woo Lee

    2014-09-01

    Full Text Available PurposeLong-acting gonadotropin-releasing hormone agonists (GnRHa are commonly used to treat central precocious puberty (CPP in Korea. Although rare, there have been reports on the characteristic of adverse reactions of GnRHa in CPP among the Korean population. This study was intended to report on our clinical experience regarding significant adverse reactions to long-acting GnRHa in CPP and early onset puberty and to evaluate the prevalence rate of serious side effects.MethodsThis retrospective study included children with CPP and early onset puberty, who were administered monthly with long-acting GnRHa (leuprolide acetate, triptorelin acetate at the outpatient clinic of Department of Pediatrics, at Inha University Hospital, between January 2011 and December 2013. We analyzed the clinical characteristics of patients who experienced significant adverse reactions and evaluated the prevalence rate.ResultsSix serious side effects (0.9% were observed among total of 621 CPP and early onset puberty children with GnRHa therapy. The number of sterile abscess formation was four in three patients (4 events of 621. Anaphylaxis occurred in only one patient, and unilateral slipped capital femoral epiphysis (SCFE in another one patient. Anaphylaxis occurred after the 6th administration of the monthly depot triptorelin acetate. Unilateral SCFE developed in GnRHa therapy.ConclusionSterile abscess formation occurred in 0.6% of CPP and early onset puberty patients from the administration of a monthly depot GnRHa therapy. The occurrences of anaphylaxis and SCFE are extremely rare, but can have serious implications on patients. Clinicians should be aware of these potential adverse effects related to GnRHa therapy in CPP.

  15. Needle-free jet injection of rapid-acting insulin improves early postprandial glucose control in patients with diabetes

    NARCIS (Netherlands)

    Engwerda, E.E.; Tack, C.J.J.; Galan, B.E. de

    2013-01-01

    OBJECTIVE: Clamp studies have shown that the absorption and action of rapid-acting insulin are faster with injection by a jet injector than with administration by conventional pen. To determine whether these pharmacokinetic changes also exist in patients with diabetes and benefit postprandial

  16. Early Childhood Interventionists' Perceptions of the Child Abuse Prevention and Treatment Act: Provider Characteristics and Organizational Climate

    Science.gov (United States)

    Herman-Smith, Robert L.

    2013-01-01

    Research Findings: A 2003 amendment to the Child Abuse Prevention and Treatment Act (CAPTA) required states to develop plans to ensure that children younger than the age of 3 years who are victims of substantiated abuse or neglect have access to developmental screenings. Programs authorized under Part C of the Individuals with Disabilities…

  17. Early Effects of the Affordable Care Act on Health Care Access, Risky Health Behaviors, and Self-Assessed Health

    OpenAIRE

    Courtemanche, Charles; Marton, James; Ukert, Benjamin; Yelowitz, Aaron; Zapata, Daniela

    2017-01-01

    The goal of the Affordable Care Act (ACA) was to achieve nearly universal health insurance coverage through a combination of mandates, subsidies, marketplaces, and Medicaid expansions, most of which took effect in 2014. We use data from the Behavioral Risk Factor Surveillance System to examine the impacts of the ACA on health care access, risky health behaviors, and self-assessed health after two years. We estimate difference-in-difference-in-differences models that exploit variation in treat...

  18. Move, Act, Play, Sing (MAPS): Exploring Early Childhood Arts Teaching and Learning Strategies and Concepts through Community Arts Interventions

    Science.gov (United States)

    Lines, David; Naughton, Chris; Roder, John; Matapo, Jacoba; Whyte, Marjolein; Liao, Tiffany

    2014-01-01

    This project/report worked with three early childhood education centres who have adopted the Reggio Emilia philosophy of educational practice. Each centre works with children and parents in close collaboration and all the staff and centre management are committed to the project. The aim of this project was to work with each centre in developing…

  19. 'Learn the signs. Act early': a campaign to help every child reach his or her full potential.

    Science.gov (United States)

    Daniel, K L; Prue, C; Taylor, M K; Thomas, J; Scales, M

    2009-09-01

    To examine the application of a social marketing approach to increase the early identification and treatment of autism and other developmental disorders. The intervention used formative research, behaviour change theory and traditional social marketing techniques to develop a campaign targeting parents, healthcare professionals and early educators to increase awareness of autism and other developmental delays, and to prompt action if a developmental delay was suspected. Using social marketing principles, the Centers for Disease Control and Prevention applied baseline research with the target audiences to understand the barriers and motivators to behaviour change, which included a lack of knowledge and resources (barriers), along with a willingness to learn and do more (motivators). Focus group testing of potential campaign concepts led to one particular approach and accompanying images, which together increased perceived severity of the problem and encouraged taking action. The audience research also helped to shape the marketing mix (product, price, place and promotion). Three-year follow-up research in this case study indicates a significant change in parent target behaviours, particularly among parents aware of the campaign, and substantially more healthcare professionals believe that they have the resources to educate parents about monitoring their child's cognitive, social and physical development. Qualitative results from early educators and childcare professional associations have been positive about products developed for daycare settings. The application of social marketing principles, behavior change theory and audience research was an effective approach to changing behaviours in this case. Understanding what the target audiences want and need, looking beyond parents to engage healthcare professionals and early educators, and engaging many strategic partners to extend the reach of the message helped campaign planners to develop a campaign that resonated

  20. Job mobility among parents of children with chronic health conditions: Early effects of the 2010 Affordable Care Act.

    Science.gov (United States)

    Chatterji, Pinka; Brandon, Peter; Markowitz, Sara

    2016-07-01

    We examine the effects of the 2010 Patient Protection and Affordable Care Act's (ACA) prohibition of preexisting conditions exclusions for children on job mobility among parents. We use a difference-in-difference approach, comparing pre-post policy changes in job mobility among privately-insured parents of children with chronic health conditions vs. privately-insured parents of healthy children. Data come from the 2004 and 2008 Survey of Income and Program Participation (SIPP). Among married fathers, the policy change is associated with about a 0.7 percentage point, or 35 percent increase, in the likelihood of leaving an employer voluntarily. We find no evidence that the policy change affected job mobility among married and unmarried mothers. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. Early Impacts of the Affordable Care Act on Health Insurance Coverage in Medicaid Expansion and Non-Expansion States.

    Science.gov (United States)

    Courtemanche, Charles; Marton, James; Ukert, Benjamin; Yelowitz, Aaron; Zapata, Daniela

    2017-01-01

    The Affordable Care Act (ACA) aimed to achieve nearly universal health insurance coverage in the United States through a combination of insurance market reforms, mandates, subsidies, health insurance exchanges, and Medicaid expansions, most of which took effect in 2014. This paper estimates the causal effects of the ACA on health insurance coverage in 2014 using data from the American Community Survey. We utilize difference-in-difference-in-differences models that exploit cross-sectional variation in the intensity of treatment arising from state participation in the Medicaid expansion and local area pre-ACA uninsured rates. This strategy allows us to identify the effects of the ACA in both Medicaid expansion and non-expansion states. Our preferred specification suggests that, at the average pre-treatment uninsured rate, the full ACA increased the proportion of residents with insurance by 5.9 percentage points compared to 2.8 percentage points in states that did not expand Medicaid. Private insurance expansions from the ACA were due to increases in both employer-provided and non-group coverage. The coverage gains from the full ACA were largest for those without a college degree, non-whites, young adults, unmarried individuals, and those without children in the home. We find no evidence that the Medicaid expansion crowded out private coverage.

  2. Predicting Early Viral Control under Direct-Acting Antiviral Therapy for Chronic Hepatitis C Virus Using Pretreatment Immunological Markers

    Directory of Open Access Journals (Sweden)

    James A. Hutchinson

    2018-02-01

    Full Text Available Recent introduction of all-oral direct-acting antiviral (DAA treatment has revolutionized care of patients with chronic hepatitis C virus (HCV infection. Regrettably, the high cost of DAA treatment is burdensome for healthcare systems and may be prohibitive for some patients who would otherwise benefit. Understanding how patient-related factors influence individual responses to DAA treatment may lead to more efficient prescribing. In this observational study, patients with chronic HCV infection were comprehensively monitored by flow cytometry to identify pretreatment immunological variables that predicted HCV RNA negativity within 4 weeks of commencing DAA treatment. Twenty-three patients [genotype 1a (n = 10, 1b (n = 9, and 3 (n = 4] were treated with daclatasvir plus sofosbuvir (SOF (n = 15, ledipasvir plus SOF (n = 4, or ritonavir-boosted paritaprevir, ombitasvir, and dasabuvir (n = 4. DAA treatment most prominently altered the distribution of CD8+ memory T cell subsets. Knowing only pretreatment frequencies of CD3+ and naive CD8+ T cells allowed correct classification of 83% of patients as “fast” (HCV RNA-negative by 4 weeks or “slow” responders. In a prospective cohort, these parameters correctly classified 90% of patients. Slow responders exhibited higher frequencies of CD3+ T cells, CD8+ TEM cells, and CD5high CD27− CD57+ CD8+ chronically activated T cells, which is attributed to bystander hyperactivation of virus-non-specific CD8+ T cells. Taken together, non-specific, systemic CD8+ T cell activation predicted a longer time to viral clearance. This discovery allows pretreatment identification of individuals who may not require a full 12-week course of DAA therapy; in turn, this could lead to individualized prescribing and more efficient resource allocation.

  3. Functionally redundant RXLR effectors from Phytophthora infestans act at different steps to suppress early flg22-triggered immunity.

    Directory of Open Access Journals (Sweden)

    Xiangzi Zheng

    2014-04-01

    Full Text Available Genome sequences of several economically important phytopathogenic oomycetes have revealed the presence of large families of so-called RXLR effectors. Functional screens have identified RXLR effector repertoires that either compromise or induce plant defense responses. However, limited information is available about the molecular mechanisms underlying the modes of action of these effectors in planta. The perception of highly conserved pathogen- or microbe-associated molecular patterns (PAMPs/MAMPs, such as flg22, triggers converging signaling pathways recruiting MAP kinase cascades and inducing transcriptional re-programming, yielding a generic anti-microbial response. We used a highly synchronizable, pathogen-free protoplast-based assay to identify a set of RXLR effectors from Phytophthora infestans (PiRXLRs, the causal agent of potato and tomato light blight that manipulate early stages of flg22-triggered signaling. Of thirty-three tested PiRXLR effector candidates, eight, called Suppressor of early Flg22-induced Immune response (SFI, significantly suppressed flg22-dependent activation of a reporter gene under control of a typical MAMP-inducible promoter (pFRK1-Luc in tomato protoplasts. We extended our analysis to Arabidopsis thaliana, a non-host plant species of P. infestans. From the aforementioned eight SFI effectors, three appeared to share similar functions in both Arabidopsis and tomato by suppressing transcriptional activation of flg22-induced marker genes downstream of post-translational MAP kinase activation. A further three effectors interfere with MAMP signaling at, or upstream of, the MAP kinase cascade in tomato, but not in Arabidopsis. Transient expression of the SFI effectors in Nicotiana benthamiana enhances susceptibility to P. infestans and, for the most potent effector, SFI1, nuclear localization is required for both suppression of MAMP signaling and virulence function. The present study provides a framework to decipher the

  4. A family inheriting different subtypes of acute myelogenous leukemia identifies a gene common to the differentation of multiple hematopoetic lineages and acting early in leukemogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Horwitz, M.S.; Radich, J. [Fred Hutchinson Cancer Research Center, Seattle, WA (United States); Sabath, D.E. [Univ. of Washington, Seattle (United States)

    1994-09-01

    The initial steps promoting carcinogenesis in the hematologic malignancies remain poorly understood. We report on a family with an incompletely penetrant, autosomal dominant syndrome of acute myelogenous leukemia, affecting at least eight adults from three generations. The affected individuals have developed leukemias differing in morphologic subtype, tumor cytogenetics, and abruptness of presentation. Within this family are found subtypes affecting the granulocytic, monocytic, and megakaryocytic lineages. At least one individual has a normal tumor karyotype while another has complex rearrangements including monsomy 7, trisomy 8 and translocation 1;7. Some have presented with acute onset and others with a protracted myelodysplasia syndrome. One person at fifty percent risk of inheriting this gene developed disseminated atypical mycobacterium infection in the absence of leukemia, but also without apparent causes for acquired deficiencies in cellular immunity. Features common to affected family members, including the individual with mycobacterium infection, are the early presence in bone marrow of red cell and platelet maturation defects. A search for mutations in diseased marrows fails to detect abnormalities of p53 exons 5, 6, 7 and 8 or N-ras codons 12, 13 and 61. We conclude that there is a gene in this family that probably acts early in hematopoetic differentiation and confers susceptibility to a wide range of leukemia subtypes spanning the maturation of the myeloid series.

  5. Large Pre- and Postexercise Rapid-Acting Insulin Reductions Preserve Glycemia and Prevent Early- but Not Late-Onset Hypoglycemia in Patients With Type 1 Diabetes

    Science.gov (United States)

    Campbell, Matthew D.; Walker, Mark; Trenell, Michael I.; Jakovljevic, Djordje G.; Stevenson, Emma J.; Bracken, Richard M.; Bain, Stephen C.; West, Daniel J.

    2013-01-01

    OBJECTIVE To examine the acute and 24-h glycemic responses to reductions in postexercise rapid-acting insulin dose in type 1 diabetic patients. RESEARCH DESIGN AND METHODS After preliminary testing, 11 male patients (24 ± 2 years, HbA1c 7.7 ± 0.3%; 61 ± 3.4 mmol/mol) attended the laboratory on three mornings. Patients consumed a standardized breakfast (1 g carbohydrate ⋅ kg−1 BM; 380 ± 10 kcal) and self-administered a 25% rapid-acting insulin dose 60 min prior to performing 45 min of treadmill running at 72.5 ± 0.9% VO2peak. At 60 min postexercise, patients ingested a meal (1 g carbohydrate ⋅ kg−1 BM; 660 ± 21 kcal) and administered a Full, 75%, or 50% rapid-acting insulin dose. Blood glucose concentrations were measured for 3 h postmeal. Interstitial glucose was recorded for 20 h after leaving the laboratory using a continuous glucose monitoring system. RESULTS All glycemic responses were similar across conditions up to 60 min postexercise. After the postexercise meal, blood glucose was preserved under 50%, but declined under Full and 75%. Thence at 3 h, blood glucose was highest under 50% (50% [10.4 ± 1.2] vs. Full [6.2 ± 0.7] and 75% [7.6 ± 1.2 mmol ⋅ L−1], P = 0.029); throughout this period, all patients were protected against hypoglycemia under 50% (blood glucose ≤3.9; Full, n = 5; 75%, n = 2; 50%, n = 0). Fifty percent continued to protect patients against hypoglycemia for a further 4 h under free-living conditions. However, late-evening and nocturnal glycemia were similar; as a consequence, late-onset hypoglycemia was experienced under all conditions. CONCLUSIONS A 25% pre-exercise and 50% postexercise rapid-acting insulin dose preserves glycemia and protects patients against early-onset hypoglycemia (≤8 h). However, this strategy does not protect against late-onset postexercise hypoglycemia. PMID:23514728

  6. Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data.

    Science.gov (United States)

    Dahal, Prabin; d'Alessandro, Umberto; Dorsey, Grant; Guerin, Philippe J; Nsanzabana, Christian; Price, Ric N; Sibley, Carol H; Stepniewska, Kasia; Talisuna, Ambrose O

    2015-09-07

    Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong sub-region and poses a major global public health threat. Slow parasite clearance is a key clinical manifestation of reduced susceptibility to artemisinin. This study was designed to establish the baseline values for clearance in patients from Sub-Saharan African countries with uncomplicated malaria treated with artemisinin-based combination therapies (ACTs). A literature review in PubMed was conducted in March 2013 to identify all prospective clinical trials (uncontrolled trials, controlled trials and randomized controlled trials), including ACTs conducted in Sub-Saharan Africa, between 1960 and 2012. Individual patient data from these studies were shared with the WorldWide Antimalarial Resistance Network (WWARN) and pooled using an a priori statistical analytical plan. Factors affecting early parasitological response were investigated using logistic regression with study sites fitted as a random effect. The risk of bias in included studies was evaluated based on study design, methodology and missing data. In total, 29,493 patients from 84 clinical trials were included in the analysis, treated with artemether-lumefantrine (n = 13,664), artesunate-amodiaquine (n = 11,337) and dihydroartemisinin-piperaquine (n = 4,492). The overall parasite clearance rate was rapid. The parasite positivity rate (PPR) decreased from 59.7 % (95 % CI: 54.5-64.9) on day 1 to 6.7 % (95 % CI: 4.8-8.7) on day 2 and 0.9 % (95 % CI: 0.5-1.2) on day 3. The 95th percentile of observed day 3 PPR was 5.3 %. Independent risk factors predictive of day 3 positivity were: high baseline parasitaemia (adjusted odds ratio (AOR) = 1.16 (95 % CI: 1.08-1.25); per 2-fold increase in parasite density, P 37.5 °C) (AOR = 1.50 (95 % CI: 1.06-2.13), P = 0.022); severe anaemia (AOR = 2.04 (95 % CI: 1.21-3.44), P = 0.008); areas of low/moderate transmission setting (AOR = 2.71 (95 % CI: 1.38-5.36), P = 0.004); and treatment with the

  7. The ND10 Component Promyelocytic Leukemia Protein Acts as an E3 Ligase for SUMOylation of the Major Immediate Early Protein IE1 of Human Cytomegalovirus.

    Science.gov (United States)

    Reuter, Nina; Schilling, Eva-Maria; Scherer, Myriam; Müller, Regina; Stamminger, Thomas

    2017-05-15

    Previous studies identified the nuclear domain 10 (ND10) components promyelocytic leukemia protein (PML), hDaxx, and Sp100 as factors of an intrinsic immune response against human cytomegalovirus (HCMV). This antiviral function of ND10, however, is antagonized by viral effector proteins like IE1p72, which induces dispersal of ND10. Furthermore, we have shown that both major immediate early proteins of HCMV, IE1p72 and IE2p86, transiently colocalize with ND10 subnuclear structures and undergo modification by the covalent attachment of SUMO. Since recent reports indicate that PML acts as a SUMO E3 ligase, we asked whether the SUMOylation of IE1p72 and IE2p86 is regulated by PML. To address this, PML-depleted fibroblasts, as well as cells overexpressing individual PML isoforms, were infected with HCMV. Western blot experiments revealed a clear correlation between the degree of IE1p72 SUMO conjugation and the abundance of PML. On the other hand, the SUMOylation of IE2p86 was not affected by PML. By performing in vitro SUMOylation assays, we were able to provide direct evidence that IE1p72 is a substrate for PML-mediated SUMOylation. Interestingly, disruption of the RING finger domain of PML, which is proposed to confer SUMO E3 ligase activity, abolished PML-induced SUMOylation of IE1p72. In contrast, IE1p72 was still efficiently SUMO modified by a SUMOylation-defective PML mutant, indicating that intact ND10 bodies are not necessary for this effect. Thus, this is the first report that the E3 ligase PML is capable of stimulating the SUMOylation of a viral protein which is supposed to serve as a cellular mechanism to compromise specific functions of IE1p72.IMPORTANCE The major immediate early proteins of human cytomegalovirus, termed IE1p72 and IE2p86, have previously been shown to undergo posttranslational modification by covalent coupling to SUMO moieties at specific lysine residues. However, the enzymatic activities that are responsible for this modification have not

  8. A Common Variant of PROK1 (V67I Acts as a Genetic Modifier in Early Human Pregnancy through Down-Regulation of Gene Expression

    Directory of Open Access Journals (Sweden)

    Mei-Tsz Su

    2016-01-01

    Full Text Available PROK1-V67I has been shown to play a role as a modifier gene in the PROK1-PROKR system of human early pregnancy. To explore the related modifier mechanism of PROK1-V67I, we carried out a comparison study at the gene expression level and the cell function alternation of V67I, and its wild-type (WT, in transiently-transfected cells. We, respectively, performed quantitative RT-PCR and ELISA assays to evaluate the protein and/or transcript level of V67I and WT in HTR-8/SV neo, JAR, Ishikawa, and HEK293 cells. Transiently V67I- or WT-transfected HTR-8/SV neo and HEK293 cells were used to investigate cell function alternations. The transcript and protein expressions were down-regulated in all cell lines, ranging from 20% to 70%, compared with WT. There were no significant differences in the ligand activities of V67I and WT with regard to cell proliferation, cell invasion, calcium influx, and tubal formation. Both PROK1 alleles promoted cell invasion and intracellular calcium mobilization, whereas they had no significant effects on cell proliferation and tubal formation. In conclusion, the biological effects of PROK1-V67I on cell functions are similar to those of WT, and the common variant of V67I may act as a modifier in the PROK1-PROKR system through down-regulation of PROK1 expression. This study may provide a general mechanism that the common variant of V67I, modifying the disease severity of PROK1-related pathophysiologies.

  9. Privacy Act

    Science.gov (United States)

    Learn about the Privacy Act of 1974, the Electronic Government Act of 2002, the Federal Information Security Management Act, and other information about the Environmental Protection Agency maintains its records.

  10. ACTING OF THE MEDICAL GENETIC ADVISORY CENTER IN THE EARLY DETECTION AND PREVENTION OF PERSONS WITH PSHYCHOPHYSICAL DISORDERS IN THEIR DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    M. KJAEVA-PEJKOVSKA

    1997-03-01

    Full Text Available There had been a great dedication on the prevention of the acquired disease in the past. The well known are eugenetic advisory centers in which people could get information for a given inherited disease, later so called genetic advisory centers. Their work, besides is based on the principles of informing the patients for the difficulties, importance and prognoses of determined inherited disease. This activity, which is the highest achievement in the medical genetics, can be called genetic information, which is very important for regular treatment of every patient.The accurate etiological diagnosis is an essential precondition for giving the genetic information, assessment of the risk, the eventual treatment, as for the prenatal diagnosis e.i. prevention of congenital malformations.The genetic consulting is applicable in all possible phenotype manifestations of the breaking genes, regardless to the categorical custody of the examinees with retards in their development. In fact, that’s a summary of standards which are applicable in the basic prevention in disabilities in the psycho-physical development, whose reasons are genetically determined. Preventive activities are mostly used with mentally retarded as a result of the frequent intercession of the psychological disorders all together in different syndromes and diseases.The genetic consulting activities of the Center for Mental Health for children and adolescents in Skopje are based on the appliance of the following methodology: fortification of the risk for the appearance of inherited anomalies; explanation and assessment of the established risk in the concrete family situation, assurance of adequate assistance concerning the accurate and practical assessment of the risk and preparation of rational plan for subsequent treatment and decisions; consequent observation of the situations and evaluation of achieved results etc. In that way, the acting of medical-genetic advising center in the

  11. ACT Test

    Science.gov (United States)

    ... Content View Sources Ask Us Also Known As ACT Activated Coagulation Time Formal Name Activated Clotting Time ... What is being tested? The activated clotting time (ACT) is a test that is used primarily to ...

  12. Arabidopsis WRKY6 Transcription Factor Acts as a Positive Regulator of Abscisic Acid Signaling during Seed Germination and Early Seedling Development

    OpenAIRE

    Yun Huang; Cui-Zhu Feng; Qing Ye; Wei-Hua Wu; Yi-Fang Chen

    2016-01-01

    The phytohormone abscisic acid (ABA) plays important roles during seed germination and early seedling development. Here, we characterized the function of the Arabidopsis WRKY6 transcription factor in ABA signaling. The transcript of WRKY6 was repressed during seed germination and early seedling development, and induced by exogenous ABA. The wrky6-1 and wrky6-2 mutants were ABA insensitive, whereas WRKY6-overexpressing lines showed ABA-hypersensitive phenotypes during seed germination and earl...

  13. ACTS 2014

    DEFF Research Database (Denmark)

    . For the 2014 festival, the museum has entered into a collaboration with the Department for Performance Design at Roskilde University – with continued focus on sound and performance art, and social art in public spaces. With ACTS, art moves out of its usual exhibition space and instead utilizes the city, its...... various possibilities and public spaces as a stage. ACTS takes place in and around the museum and diverse locations in Roskilde city. ACTS is partly curated by the museum staff and partly by guest curators. ACTS 2014 is supported by Nordea-fonden and is a part of the project The Museum goes downtown.......Co-curator of ACTS 2014 together with Rasmus Holmboe, Judith Schwarzbart and Sanne Kofoed. ACTS is the Museum of Contemporary Art’s international bi-annual festival. ACTS was established in 2011 and, while the primary focus is on sound and performance art, it also looks toward socially oriented art...

  14. Addressing Disparities in Parent Education: Examining the Effects of Learn the Signs/Act Early Parent Education Materials on Parent Outcomes

    Science.gov (United States)

    Graybill, Emily; Self-Brown, Shannon; Lai, Betty; Vinoski, Erin; McGill, Tia; Crimmins, Daniel

    2016-01-01

    Early intervention is critical for improved prognosis and quality of life for young children with developmental delays and disabilities. Yet, disparities persist among underserved families with young children. These disparities include knowledge of child development, use of medical providers as referral sources, and later diagnosis. The current…

  15. Arabidopsis WRKY6 Transcription Factor Acts as a Positive Regulator of Abscisic Acid Signaling during Seed Germination and Early Seedling Development.

    Directory of Open Access Journals (Sweden)

    Yun Huang

    2016-02-01

    Full Text Available The phytohormone abscisic acid (ABA plays important roles during seed germination and early seedling development. Here, we characterized the function of the Arabidopsis WRKY6 transcription factor in ABA signaling. The transcript of WRKY6 was repressed during seed germination and early seedling development, and induced by exogenous ABA. The wrky6-1 and wrky6-2 mutants were ABA insensitive, whereas WRKY6-overexpressing lines showed ABA-hypersensitive phenotypes during seed germination and early seedling development. The expression of RAV1 was suppressed in the WRKY6-overexpressing lines and elevated in the wrky6 mutants, and the expression of ABI3, ABI4, and ABI5, which was directly down-regulated by RAV1, was enhanced in the WRKY6-overexpressing lines and repressed in the wrky6 mutants. Electrophoretic mobility shift and chromatin immunoprecipitation assays showed that WRKY6 could bind to the RAV1 promoter in vitro and in vivo. Overexpression of RAV1 in WRKY6-overexpressing lines abolished their ABA-hypersensitive phenotypes, and the rav1 wrky6-2 double mutant showed an ABA-hypersensitive phenotype, similar to rav1 mutant. Together, the results demonstrated that the Arabidopsis WRKY6 transcription factor played important roles in ABA signaling by directly down-regulating RAV1 expression.

  16. Balancing Acts

    Science.gov (United States)

    ... Current Issue Past Issues Special Section: Focus on Communication Balancing Acts Past Issues / Fall 2008 Table of ... It was like watching a movie, but every couple of frames were skipping. It was disorienting," the ...

  17. Subjective experiences of compulsory treatment from a qualitative study of early implementation of the Mental Health (Care & Treatment) (Scotland) Act 2003.

    Science.gov (United States)

    Ridley, Julie; Hunter, Susan

    2013-09-01

    Compulsory psychiatric treatment is highly contested, and little research has focused specifically on direct experiences. The Mental Health (Care & Treatment) (Scotland) Act, 2003 introduced new roles and provisions including community treatment orders, and was designed to increase participation, ensure treatment was beneficial and was the 'least restrictive' alternative. This article draws on findings from semi-structured interviews with 49 individuals, who had experienced compulsion under this new legislation during 2007-2008, that were part of a broader cohort study. Interviews with service users were conducted at two stages with 80% agreeing to be interviewed twice. The sample included people on a variety of compulsory orders from four Health Board areas, some of whom had been detained for the first time, while others reported 'revolving door' experiences. Peer researchers who were mental health service users carried out the interviews in partnership with professional researchers. The findings suggest that legislation had a limited impact on participation in the process of compulsion. Consensus was that although service users felt there was increased opportunity for their voices to be heard, this was not matched by having increased influence over professional decision-making, especially in relation to drug treatments. According to people's direct experiences, the passing of the legislation in itself had done little to change the dominant psychiatric paradigm. While providing a foundation for improving the process of compulsion, the findings suggest that as well as legislative reform, fundamental shifts in practice are needed both in terms of the nature of therapeutic relationships, and in embracing more holistic and recovery perspectives. © 2013 Blackwell Publishing Ltd.

  18. A combined early cognitive and physical rehabilitation program for people who are critically ill: the activity and cognitive therapy in the intensive care unit (ACT-ICU) trial.

    Science.gov (United States)

    Brummel, Nathan E; Jackson, James C; Girard, Timothy D; Pandharipande, Pratik P; Schiro, Elena; Work, Brittany; Pun, Brenda T; Boehm, Leanne; Gill, Thomas M; Ely, E Wesley

    2012-12-01

    In the coming years, the number of survivors of critical illness is expected to increase. These survivors frequently develop newly acquired physical and cognitive impairments. Long-term cognitive impairment is common following critical illness and has dramatic effects on patients' abilities to function autonomously. Neuromuscular weakness affects similar proportions of patients and leads to equally profound life alterations. As knowledge of these short-term and long-term consequences of critical illness has come to light, interventions to prevent and rehabilitate these devastating consequences have been sought. Physical rehabilitation has been shown to improve functional outcomes in people who are critically ill, but subsequent studies of physical rehabilitation after hospital discharge have not. Post-hospital discharge cognitive rehabilitation is feasible in survivors of critical illness and is commonly used in people with other forms of acquired brain injury. The feasibility of early cognitive therapy in people who are critically ill remains unknown. The purpose of this novel protocol trial will be to determine the feasibility of early and sustained cognitive rehabilitation paired with physical rehabilitation in patients who are critically ill from medical and surgical intensive care units. This is a randomized controlled trial. The setting for this trial will be medical and surgical intensive care units of a large tertiary care referral center. The participants will be patients who are critically ill with respiratory failure or shock. Patients will be randomized to groups receiving usual care, physical rehabilitation, or cognitive rehabilitation plus physical rehabilitation. Twice-daily cognitive rehabilitation sessions will be performed with patients who are noncomatose and will consist of orientation, memory, and attention exercises (eg, forward and reverse digit spans, matrix puzzles, letter-number sequences, pattern recognition). Daily physical

  19. Combining Active Immunization with Monoclonal Antibody Therapy To Facilitate Early Initiation of a Long-Acting Anti-Methamphetamine Antibody Response.

    Science.gov (United States)

    Hambuchen, Michael D; Carroll, F Ivy; Rüedi-Bettschen, Daniela; Hendrickson, Howard P; Hennings, Leah J; Blough, Bruce E; Brieaddy, Lawrence E; Pidaparthi, Ramakrishna R; Owens, S Michael

    2015-06-11

    We hypothesized that an anti-METH mAb could be used in combination with a METH-conjugate vaccine (MCV) to safely improve the overall quality and magnitude of the anti-METH immune response. The benefits would include immediate onset of action (from the mAb), timely increases in the immune responses (from the combined therapy) and duration of antibody response that could last for months (from the MCV). A novel METH-like hapten (METH-SSOO9) was synthesized and then conjugated to immunocyanin monomers of keyhole limpet hemocyanin (IC(KLH)) to create the MCV ICKLH-SOO9. The vaccine, in combination with previously discovered anti-METH mAb7F9, was then tested in rats for safety and potential efficacy. The combination antibody therapy allowed safe achievement of an early high anti-METH antibody response, which persisted throughout the study. Indeed, even after 4 months the METH vaccine antibodies still had the capacity to significantly reduce METH brain concentrations resulting from a 0.56 mg/kg METH dose.

  20. Npa1p is an essential trans-acting factor required for an early step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae

    Science.gov (United States)

    ROSADO, IVÁN V.; DE LA CRUZ, JESÚS

    2004-01-01

    Ribosome biogenesis requires >100 nonribosomal proteins, which are associated with different preribosomal particles. The substrates, the interacting partners, and the timing of action of most of these proteins are largely unknown. To elucidate the functional environment of the putative ATP-dependent RNA helicase Dbp6p from Saccharomyces cerevisiae, which is required for 60S ribosomal subunit assembly, we have previously performed a synthetic lethal screen and thereby revealed a genetic interaction network between Dbp6p, Rpl3p, Nop8p, and the novel Rsa3p. In this report, we extended the characterization of this functional network by performing a synthetic lethal screen with the rsa3 null allele. This screen identified the so far uncharacterized Npa1p (YKL014C). Polysome profile analysis indicates that there is a deficit of 60S ribosomal subunits and an accumulation of halfmer polysomes in the slowly growing npa1-1 mutant. Northern blotting and primer extension analysis shows that the npa1-1 mutation negatively affects processing of all 27S pre-rRNAs and the normal accumulation of both mature 25S and 5.8S rRNAs. In addition, 27SA2 pre-rRNA is prematurely cleaved at site C2. Moreover, GFP-tagged Npa1p localizes predominantly to the nucleolus and sediments with large complexes in sucrose gradients, which most likely correspond to pre-60S ribosomal particles. We conclude that Npa1p is required for ribosome biogenesis and operates in the same functional environment of Rsa3p and Dbp6p during early maturation of 60S ribosomal subunits. PMID:15208443

  1. Early Retiree Reinsurance Program Reports

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Early Retiree Reinsurance Program (ERRP) was established by section 1102 of the Patient Protection and Affordable Care Act (the Affordable Care Act) enacted on...

  2. [Schema therapy - ACT - mindfulness].

    Science.gov (United States)

    Cousineau, Pierre; Ngô, Thanh-Lan

    2013-01-01

    For schema therapy, significant weight is given to early experiences of social life. They lead to the creation of memories, largely implicit. These memories are reactivated in specific contexts and are often managed through dysfunctional strategies. Schema therapy seeks to modify these memories categorized as patterns. Acceptance and Commitment Therapy (ACT), meanwhile, aims to transform our reactions linked to our learning history and to develop a greater flexibility taking into account what occurs in the present moment. Several techniques originate from the mindfulness tradition and seek to transform the individual into a witness of his own experience, rather than someone acting out patterns based on his learning history. Despite their different paradigms, it is possible to combine these approaches. As schemas manifest through somatic reactions, thoughts, affects, action tendencies, it becomes possible to try to change the relationship between the individual and these private experiences through the use of mindfulness, philosophical concepts and techniques derived from ACT. This is the aim of this article. Essay presenting the use of a schema mindfulness flash card to help patients tolerate intense affects generated by the activation of schemas and to attain greater adaptive flexibility (Healthy Adult mode). It is possible to integrate ACT techniques and concept to schema therapy in order to facilitate adaptive flexibility.

  3. 77 FR 27532 - No FEAR Act Notice

    Science.gov (United States)

    2012-05-10

    ... Act for Fiscal Year 2008 (Pub. L. 110-181), which created the Special Inspector General for... diverse workforce, early and alternative conflict resolution, and essential communications skills Conduct...

  4. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... that affects the pancreas and other organs, and how to treat and live with this chronic disease. Role ... of your CF care team can show you how to perform many different ACTs and recommend specific ACTs ...

  5. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... Treatments and Therapies Airway Clearance Airway Clearance Techniques (ACTs) There are different ways to clear your airways. ... or caregiver. Older kids and adults can choose ACTs that they can do on their own. Share ...

  6. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... CF Treatments and Therapies Airway Clearance Airway Clearance Techniques (ACTs) There are different ways to clear your ... for fitting ACTs into daily life Airway Clearance Techniques | Webcast To learn more about how you can ...

  7. Holophrases, Speech Acts and Language Universals

    Science.gov (United States)

    Dore, John

    1975-01-01

    The arguments for and against viewing the child's initial one-word utterances as holophrases are reviewed. An alternative view of early language development, which takes the speech act as the basic unit of linguistic communication, rather than the sentence, is offered as a solution to the holophrase controversy. (Author/RM)

  8. 25 CFR 700.33 - Act (The Act).

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Act (The Act). 700.33 Section 700.33 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES General Policies and Instructions Definitions § 700.33 Act (The Act). (a) The Act. The Act is Pub. L. 93-531, (88 Stat...

  9. The Child Justice Act

    African Journals Online (AJOL)

    Stephan

    1995-06-16

    Jun 16, 1995 ... I want to express my gratitude to them all. 1 In the past a few different categories of young offenders were specifically addressed in our law. For example, s 290 of the Criminal Procedure Act 51 of 1977 (before its repeal by the Child. Justice Act 75 of 2008) had specific provisions for "young offenders" under ...

  10. ACT and College Success

    Science.gov (United States)

    Bleyaert, Barbara

    2010-01-01

    What is the relationship between ACT scores and success in college? For decades, admissions policies in colleges and universities across the country have required applicants to submit scores from a college entrance exam, most typically the ACT (American College Testing) or SAT (Scholastic Aptitude Test). This requirement suggests that high school…

  11. Marine Mammal Protection Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Marine Mammal Protection Act (MMPA or Act) prohibits, with certain exceptions, the "take" of marine mammals in U.S. waters and by U.S. citizens on the high seas,...

  12. Transitions as Speech Acts.

    Science.gov (United States)

    Fesmire, Alice Ann

    1993-01-01

    Reviews speech act theory to explain the function of writing transitions in terms of the illocutionary and perlocutionary effect of explicit performatives. Identifies explicit performatives in samples of professional writing in technical and academic areas. Suggest ways to revise textbooks to include the findings from speech act theory. (SR)

  13. Acts of kindness and acts of novelty affect life satisfaction.

    Science.gov (United States)

    Buchanan, Kathryn E; Bardi, Anat

    2010-01-01

    The present experiment was designed to establish the effects of acts of kindness and acts of novelty on life satisfaction. Participants aged 18-60 took part on a voluntary basis. They were randomly assigned to perform either acts of kindness, acts of novelty, or no acts on a daily basis for 10 days. Their life satisfaction was measured before and after the 10-day experiment. As expected, performing acts of kindness or acts of novelty resulted in an increase in life satisfaction.

  14. Draconian dress act repealed.

    Science.gov (United States)

    Mhone, C

    1994-01-01

    The Dress Act was put into place in Malawi by the government of President Kamuzu Banda after the long period of direct colonialism. The act made it illegal for women in Malawi to be seen publicly wearing dresses which did not completely cover their knees or wearing pants; men had to wear their hair short. Police officers even scrutinized women's attire at private house parties and in homes. The autocratic political structure established by Banda, however, was voted out in a referendum June 14, 1993. Pressure by opposition forces such as the United Democratic Front forced a repeal of the act on November 16 of the same year. The repeal was vigorously attacked by female Parliament members as a move which would result in moral degradation and an increase in the level of sexual harassment against women. Other citizens and tourists have generally detested the act. The act has most certainly kept many potential visitors from vacationing in Malawi. Some expert observers think that repeals of the Dress Act, the Forfeiture Act, and legislation which allowed the government to detain opposition figures without trial were done to garner support from the Paris Club for the resumption of balance of payments support suspended due to the country's poor human rights record.

  15. Sarbanes Oxley Act

    OpenAIRE

    Těšínský, Josef

    2011-01-01

    The diploma thesis is focused on corporate fraud problematic, on The Sarbanes-Oxley Act of 2002 and on problematics of internal control systems and corporate governance, which relate closely with the Sarbanes-Oxley act. The goal of my diploma thesis is to highlight the significance of corporate fraud problematic and create an integrated summary of requirements placed on companies, which either have to or want to comply with the Sarbanes-Oxley act. The opening part of the diploma thesis is foc...

  16. The Experiment as Act

    DEFF Research Database (Denmark)

    Søndergaard, Morten

    to identify and locate the experiments of POEX65 as acts; and to ask the questions: what constitutes those acts as experiments? and how do we possibly archive them? My purpose, then, is to define the methodologies to obtain the contours of a post-phenomenology of experimental artistic production in order...... to be able to analyse the phenomena found at POEX65. Here I will use the notion of the ‘ontological theatre’ (Pickering), which, according to Pickering, is acted out in experimental art productions. The experiment could thus be seen as an ‘agency-realism’ – as an ‘act’ of relations across the aesthetics...

  17. Mak5 and Ebp2 act together on early pre-60S particles and their reduced functionality bypasses the requirement for the essential pre-60S factor Nsa1.

    Directory of Open Access Journals (Sweden)

    Dagmar Pratte

    Full Text Available Ribosomes are the molecular machines that translate mRNAs into proteins. The synthesis of ribosomes is therefore a fundamental cellular process and consists in the ordered assembly of 79 ribosomal proteins (r-proteins and four ribosomal RNAs (rRNAs into a small 40S and a large 60S ribosomal subunit that form the translating 80S ribosomes. Most of our knowledge concerning this dynamic multi-step process comes from studies with the yeast Saccharomyces cerevisiae, which have shown that assembly and maturation of pre-ribosomal particles, as they travel from the nucleolus to the cytoplasm, relies on a multitude (>200 of biogenesis factors. Amongst these are many energy-consuming enzymes, including 19 ATP-dependent RNA helicases and three AAA-ATPases. We have previously shown that the AAA-ATPase Rix7 promotes the release of the essential biogenesis factor Nsa1 from late nucleolar pre-60S particles. Here we show that mutant alleles of genes encoding the DEAD-box RNA helicase Mak5, the C/D-box snoRNP component Nop1 and the rRNA-binding protein Nop4 bypass the requirement for Nsa1. Interestingly, dominant-negative alleles of RIX7 retain their phenotype in the absence of Nsa1, suggesting that Rix7 may have additional nuclear substrates besides Nsa1. Mak5 is associated with the Nsa1 pre-60S particle and synthetic lethal screens with mak5 alleles identified the r-protein Rpl14 and the 60S biogenesis factors Ebp2, Nop16 and Rpf1, which are genetically linked amongst each other. We propose that these 'Mak5 cluster' factors orchestrate the structural arrangement of a eukaryote-specific 60S subunit surface composed of Rpl6, Rpl14 and Rpl16 and rRNA expansion segments ES7L and ES39L. Finally, over-expression of Rix7 negatively affects growth of mak5 and ebp2 mutant cells both in the absence and presence of Nsa1, suggesting that Rix7, at least when excessively abundant, may act on structurally defective pre-60S subunits and may subject these to degradation.

  18. 75 FR 63703 - Privacy Act of 1974; Privacy Act Regulation

    Science.gov (United States)

    2010-10-18

    ... CFR Part 261a Privacy Act of 1974; Privacy Act Regulation AGENCY: Board of Governors of the Federal...) is issuing a final rule to amend its regulation implementing the Privacy Act of 1974 (Privacy Act..., and applicants for Board employment, for access to their records under the Privacy Act; the amendment...

  19. Energy Policy Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Energy Policy Act (EPA) addresses energy production in the United States, including: (1) energy efficiency; (2) renewable energy; (3) oil and gas; (4) coal; (5)...

  20. Clean Water Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Clean Water Act (CWA) establishes the basic structure for regulating discharges of pollutants into U.S. waters and regulating quality standards for surface...

  1. Affordable Care Act (ACA)

    Data.gov (United States)

    Social Security Administration — The Affordable Care Act (ACA) is a federal statute enacted with a goal of increasing the quality and affordability of health insurance. Through a web service, CMS...

  2. Endangered Species Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The purpose of the Endangered Species Act (ESA) is to protect and recover imperiled species and the ecosystems upon which they depend. The U.S. Fish and Wildlife...

  3. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... CYSTIC FIBROSIS Learn about cystic fibrosis, a genetic lung disorder that affects the pancreas and other organs, ... Clearance Techniques (ACTs) Autogenic Drainage (AD) Basics of Lung Care Chest Physical Therapy Coughing and Huffing High- ...

  4. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... resources you need to continuously build upon this work. Awards and Grants Career Development Awards Research Awards ... The Preserving Employee Wellness Programs Act Our Advocacy Work Advocacy Achievements Advocacy News Briefings, Testimonies, and Regulatory ...

  5. Abandoned Shipwreck Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Abandoned Shipwreck Act of 1987 (ASA) affirms the authority of state governments to claim ownership to, protect, and manage abandoned shipwrecks on state...

  6. Act250 Permits

    Data.gov (United States)

    Vermont Center for Geographic Information — The dataset includes the geographic location for Act 250 permits issued since the inception of the law in 1970. Base permit numbers only are included; permit...

  7. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... Team Your cystic fibrosis care team includes a group of CF health care professionals who partner with ... Airway Clearance Airway Clearance Techniques (ACTs) There are different ways to clear your airways. Most are easy ...

  8. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... Twitter YouTube Instagram Email DONATE Breadcrumb Navigation Home Life With CF Treatments and Therapies Airway Clearance Airway Clearance Techniques (ACTs) There are different ways to clear your airways. Most are easy to ...

  9. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... Airway Clearance Airway Clearance Techniques (ACTs) There are different ways to clear your airways. Most are easy ... to loosen mucus from airway walls. See how different airway clearance techniques work to help you clear ...

  10. DREAM Act, Part II

    National Research Council Canada - National Science Library

    Miranda, María Eugenia

    2011-01-01

    .... For nearly a decade Congress has failed to pass a bill - the Development Relief and Education for Alien Minors Act - that would grant AJulema legal residence and free her from a life in the shadows...

  11. Clean Water Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data represent geographic terms used within the Clean Water Act (CWA). The CWA establishes the basic structure for regulating the addition of pollutants...

  12. ACT250 Districts

    Data.gov (United States)

    Vermont Center for Geographic Information — The ACT 250 Districts layer is part of a larger dataset that contains administrative boundaries for Vermont's Agency of Natural Resources. The dataset includes...

  13. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... What to Consider Regarding a Lung Transplant Medications Antibiotics Bronchodilators Mucus Thinners Nebulizer Care at Home Vascular ... that help thin and move the mucus, and antibiotics. Bronchodilators should be inhaled before you start ACTs. ...

  14. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... an eCard Submit Your Artwork Honor a Loved One Create a Tribute Page Find a Tribute Page ... to try. However, the best ACT is the one that you are most likely to perform as ...

  15. Acts of Research

    DEFF Research Database (Denmark)

    Nelund, Sidsel

    described as knowledge producers and exhibitions and art works as instances of knowledge production. Acts of Research: Knowledge Production in Contemporary Arts between Knowledge Economy and Critical Practices analyses this development. The academic discussion of knowledge production in the arts has taken...... place mostly in seminars and articles, in which knowledge is often discussed as an intrinsic quality of the artwork. Acts of Research, however, is devoted to studying the rise of knowledge production in contemporary art from the perspective of artistic, curatorial and educational research...... with an awareness of larger political, economic, geographical and art-related aspects. The concept of ‘acts of research’ is suggested as a way to understand knowledge production as a creative act in which research carried out in relation to a specific material challenges and resists the protocols of conventional...

  16. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... NACFC Carolyn and C. Richard Mattingly Leadership in Mental Health Care Award Mary M. Kontos Award NACFC ... you clear the thick, sticky mucus from your lungs. ACTs are often used with other treatments, including ...

  17. Marine Pollution Prevention Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Marine Pollution Prevention Act of 2008 implements the International Convention for the Prevention of Pollution from Ships, including related Protocols (MARPOL)...

  18. National Environmental Policy Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Environmental Policy Act (NEPA) was the first major environmental law in the United States and established national environmental policies for the...

  19. Effect of C/T -13910 cis-acting regulatory variant on expression and activity of lactase in Indian children and its implication for early genetic screening of adult-type hypolactasia.

    Science.gov (United States)

    Kuchay, Raja A H; Thapa, Babu R; Mahmood, Akhtar; Mahmood, Safrun

    2011-10-09

    , predictive value of genetic test based on C/T -13910 variant for adult-type hypolactasia was 100% in children>8 years of age. C/T -13910 cis-acting regulatory variant located ≈14 kb upstream of lactase gene (LCT) completely correlates with lactase phenotype in Indian children. The genetic testing for the C/T -13910 variant may be helpful in the diagnosis of adult-type hypolactasia in Indian children. Copyright © 2011 Elsevier B.V. All rights reserved.

  20. The acts of a speech act: An examination of a courtroom discourse ...

    African Journals Online (AJOL)

    This essay begins by suggesting that early works in the speech act theory exhibit some inadequacies, especially the use of idealized utterances and speakers isolated from natural contexts. It goes on to provide a review of theoretical issues by highlighting the major focus in the theory; the exploration of how the theory ...

  1. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... ACTIONS Health Care Reform Priorities for the CF Community in Health Care Reform Milestones in Health Care Reform How Tax Reform Could Impact People With CF The Preserving Employee Wellness Programs Act Our Advocacy ... We recognize the value of tapping into the ...

  2. Special Appropriation Act Projects

    Science.gov (United States)

    EPA is sometimes directed to provide funding to a specific entity for study, purpose, or activity.This information will be of interest to a community or other entity that has been identified in one of EPA's appropriations acts to receive such funding.

  3. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... toddlers will need help from a parent or caregiver. Older kids and adults can choose ACTs that they can do on their ... (clapping) or vibration to loosen mucus from airway walls. See how different airway clearance techniques work to help you clear the thick, sticky mucus ...

  4. Early dislodgement of Indwelling Pleural Catheter (IPC): a balancing act.

    Science.gov (United States)

    Tung, Alvin Hon Man; Ngai, Jenny Chun Li; Ng, Susanna So Shan; Ko, Fanny Wai San; Hui, David Shu-Cheong

    2014-03-01

    A 63-year-old nonsmoker with right malignant pleural effusion derived symptomatic benefit following drainage of his effusion. Following insertion of indwelling pleural catheter (IPC), 1.3 L of blood-stained fluid was drained into underwater sealed bottle (Atrium®), but the IPC dislodged 26 h after continuous connection. We believe that the weight of the drainage bottle (including the un-emptied fluid) and the prolonged connection time contributed to this uncommon event reported in the literature. There was no recurrence when his second IPC was connected to a drainage bag which was emptied at every 500 mL, capped at 2 h each time. An anchoring stitch should also be considered when drainage devices heavier than the manufacturer bottles are used to drain IPC.

  5. Dreams and acting out.

    Science.gov (United States)

    Grinberg, L

    1987-01-01

    Dreams can be used as containers that free patients from increased tension. This may be the principal function of certain types of dreams, called "evacuative dreams." They are dreams used for getting rid of unbearable affects and unconscious fantasies, or as a safety valve for partial discharge of instinctual drives. These dreams are observed primarily in borderline and psychotic patients, but can also be seen in the regressive states of neurotic patients during weekends and other periods of separation. Such dreams have to be differentiated from "elaborative dreams," which have a working-through function and stand in an inverse relationship to acting out: the greater the production of elaborative dreams, the less the tendency to act out, and vice versa.

  6. ST–ACTS

    DEFF Research Database (Denmark)

    Gidofalvi, Gyozo; Pedersen, Torben Bach

    2006-01-01

    hot issue in the area of spatio–temporal databases [7]. While existing Moving Object Simulators (MOSs) address different physical aspects of mobility, they neglect the important social and geo–demographical aspects of it. This paper presents ST–ACTS, a Spatio–Temporal ACTivity Simulator that, usi......–temporal distributions of activities, which make it essential for the development of adequate spatiotemporal data management and data mining techniques....... various geo–statistical data sources and intuitive principles, models the so far neglected aspects. ST–ACTS considers that (1) objects (representing mobile users) move from one spatio–temporal location to another with the objective of performing a certain activity at the latter location; (2) not all users...

  7. RECOGNISING SPEECH ACTS

    Directory of Open Access Journals (Sweden)

    Phyllis Kaburise

    2012-09-01

    Full Text Available Speech Act Theory (SAT, a theory in pragmatics, is an attempt to describe what happens during linguistic interactions. Inherent within SAT is the idea that language forms and intentions are relatively formulaic and that there is a direct correspondence between sentence forms (for example, in terms of structure and lexicon and the function or meaning of an utterance. The contention offered in this paper is that when such a correspondence does not exist, as in indirect speech utterances, this creates challenges for English second language speakers and may result in miscommunication. This arises because indirect speech acts allow speakers to employ various pragmatic devices such as inference, implicature, presuppositions and context clues to transmit their messages. Such devices, operating within the non-literal level of language competence, may pose challenges for ESL learners.

  8. A Vanishing Act

    DEFF Research Database (Denmark)

    la Cour, Anders; Hecht, Janus; Stilling, Maria Kirstine

    2016-01-01

    The use of information and communication technology (ICT) has played an important role in the reforms that have taken place in Western welfare societies over the past two decades. ICT is regarded as a way to provide transparency and information exchange among providers, users and politicians. Thi...... internal contradictions in the organization of elderly home care services so that key processes have become outright invisible. This trick, the paper argues, is essentially an act of what Bourdieu calls social magic....

  9. Toxic Substances Control Act

    Energy Technology Data Exchange (ETDEWEB)

    1992-05-15

    This Reference Book contains a current copy of the Toxic Substances Control Act and those regulations that implement the statute and appear to be most relevant to DOE activities. The document is provided to DOE and contractor staff for informational purposes only and should not be interpreted as legal guidance. Questions concerning this Reference Book may be directed to Mark Petts, EH-231 (202/586-2609).

  10. Williamson Act - The California Land Conservation Act of 1965

    Data.gov (United States)

    California Department of Resources — The California Land Conservation Act of 1965 - commonly referred to as the Williamson Act - is the State's primary program for the conservation of private land in...

  11. Early literacy

    DEFF Research Database (Denmark)

    Jensen, Anders Skriver

    2012-01-01

    This paper discusses findings from the Danish contribution to the EASE project, a European research project running from 2008 to 2010 on early literacy in relation to the transition from childcare to school. It explores a holistic, inclusive approach to early literacy that resists a narrow...... and schools. The paper also draws on Gee’s (2001, 2003, 2004, 2008) sociocultural approach to literacy, and Honneth’s (2003, 2006) concept of recognition. Emphasizing participation and recognition as key elements, it claims that stakeholders in early liter- acy must pay attention to how diverse early literacy...... opportunities empower children, especially when these opportunities are employed in a project-based learning environ- ment in which each child is able to contribute to the shared literacy events....

  12. 'Think globally, act locally'

    DEFF Research Database (Denmark)

    Hoff, Jens Villiam

    2015-01-01

    This chapter argues that citizen participation in environmental and climate policies has moved through four phases from the early 1960s until today. The most recent phase is characterised by a ‘reorientation towards the local’, a move which is increasingly supported by actors at both national and...

  13. Acting Like Rain

    Science.gov (United States)

    Baldwin, Kathryn; Wilson, Allison

    2017-01-01

    Having high-quality early childhood education programs that prepare children for success in school and later years continues to be an ever increasing national priority. While the "Next Generation Science Standards" ("NGSS") do not provide standards for preschool, there are ample opportunities to use the Standards as a guide to…

  14. Infants' unprovoked acts of force toward others.

    Science.gov (United States)

    Dahl, Audun

    2016-11-01

    Infants harm others at higher rates than older children and adults. A common explanation is that infants fail to regulate their frustration, becoming aggressive when they do not get what they want. The present research investigated whether infants also use force against others without provocation, for instance because they seek to explore the consequences of hitting or try to pet someone using too much force. Two studies with infants aged 11 to 24 months investigated infants' use of force against others in everyday life using maternal report (Study 1) and direct observation (Study 2). In both studies, a large proportion of infants' acts of force were unprovoked and occurred without signs of infant distress. Unlike provoked acts, unprovoked acts showed a decrease late in the second year and were positively associated with reports of infant pleasure-proneness. The presence of unprovoked acts of harm may reflect that infants' actions are not reliably guided by an aversion for harming others and may provide unique opportunities for early moral development. © 2015 John Wiley & Sons Ltd.

  15. Ascriptive speech act and legal language

    Directory of Open Access Journals (Sweden)

    Ogleznev Vitaly

    2016-01-01

    Full Text Available In this article the author explicates Herbert Hart’s theory of an ascriptive language as it has been developed in his influential early paper “The Ascription of Responsibility and Rights”. In the section ‘Discussion’ the author argues that the theory of ascriptive legal utterances, which is grounded on Austin’s and Searle’s theory of a speech act, provides the methodological basis for his analytical approach to philosophical and legal issues. In the section ‘Results’ the author justifies that an ascriptive is a specific speech (illocutionary act. In the section ‘Conclusion’ the matter concerns the original linguistic formula of an ascriptive that accurately reflects its nature. This article elaborates on the interpretation of ascriptive speech acts in legal language by evaluating the influence of philosophy of language on the formation of modern legal philosophy, along with evaluating the contribution of conceptual development of legal philosophy in the speech acts theory.

  16. Teaching Speech Acts

    Directory of Open Access Journals (Sweden)

    Teaching Speech Acts

    2007-01-01

    Full Text Available In this paper I argue that pragmatic ability must become part of what we teach in the classroom if we are to realize the goals of communicative competence for our students. I review the research on pragmatics, especially those articles that point to the effectiveness of teaching pragmatics in an explicit manner, and those that posit methods for teaching. I also note two areas of scholarship that address classroom needs—the use of authentic data and appropriate assessment tools. The essay concludes with a summary of my own experience teaching speech acts in an advanced-level Portuguese class.

  17. The Act of Walking

    DEFF Research Database (Denmark)

    Vestergaard, Maria Quvang Harck; Olesen, Mette; Helmer, Pernille Falborg

    2014-01-01

    perception of ‘walkability’ is based upon a subjective judgement of different physical factors, such as sidewalk width, traffic volumes and building height (Ewing and Handy 2009:67). And iIn order to understand the act of walking it is therefore necessary to create a vocabulary to understand how and why...... internalize the common norms and values of pedestrian culture and are influenced by their physical environment when walking. In conclusion the chapter questions and discusses how this knowledge could be used in future planning practices....

  18. 76 FR 59073 - Privacy Act

    Science.gov (United States)

    2011-09-23

    ... 32 CFR Part 1901 Privacy Act AGENCY: Central Intelligence Agency. ACTION: Proposed rule. SUMMARY: Consistent with the Privacy Act (PA), the Central Intelligence Agency (CIA) has undertaken and completed a... Act (PA), the CIA has undertaken and completed a review of its public PA regulations. As a result of...

  19. 78 FR 73466 - Privacy Act

    Science.gov (United States)

    2013-12-06

    ... CORPORATION 22 CFR Part 707 Privacy Act AGENCY: Overseas Private Investment Corporation. ACTION: Notice of... (``OPIC'') Privacy Act (``PA'') regulations by making substantive and administrative changes. These... confidential or inappropriate for public disclosure. Regulatory Flexibility Act (5 U.S.C. 601 et seq.) Pursuant...

  20. Speech Acts and Rhetorical Action.

    Science.gov (United States)

    Steinmann, Martin, Jr.

    Some authorities wish to persuasively define rhetoric as formal or public speeches, while others hold to a more traditional and broader definition pointing to the relevance of speech-act theory to support them. Central to speech-act theory is the illocutionary act (uttering at least one sentence of some language under certain conditions). Two…

  1. Speech Acts and Conversational Interaction.

    Science.gov (United States)

    Geis, Michael L.

    This book unites speech act theory and conversation analysis to advance a theory of conversational competence, called the Dynamic Speech Act Theory (DSAT). In contrast to traditional speech act theory that focuses almost exclusively on intuitive assessments of isolated, constructed examples, this theory is predicated on the assumption that speech…

  2. 39 CFR 775.7 - Planning and early coordination.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Planning and early coordination. 775.7 Section 775.7 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS NATIONAL ENVIRONMENTAL POLICY ACT PROCEDURES § 775.7 Planning and early coordination. Early planning and coordination among...

  3. Conversation, speech acts, and memory.

    Science.gov (United States)

    Holtgraves, Thomas

    2008-03-01

    Speakers frequently have specific intentions that they want others to recognize (Grice, 1957). These specific intentions can be viewed as speech acts (Searle, 1969), and I argue that they play a role in long-term memory for conversation utterances. Five experiments were conducted to examine this idea. Participants in all experiments read scenarios ending with either a target utterance that performed a specific speech act (brag, beg, etc.) or a carefully matched control. Participants were more likely to falsely recall and recognize speech act verbs after having read the speech act version than after having read the control version, and the speech act verbs served as better recall cues for the speech act utterances than for the controls. Experiment 5 documented individual differences in the encoding of speech act verbs. The results suggest that people recognize and retain the actions that people perform with their utterances and that this is one of the organizing principles of conversation memory.

  4. Triple acting radial seal

    Science.gov (United States)

    Ebert, Todd A [West Palm Beach, FL; Carella, John A [Jupiter, FL

    2012-03-13

    A triple acting radial seal used as an interstage seal assembly in a gas turbine engine, where the seal assembly includes an interstage seal support extending from a stationary inner shroud of a vane ring, the interstage seal support includes a larger annular radial inward facing groove in which an outer annular floating seal assembly is secured for radial displacement, and the outer annular floating seal assembly includes a smaller annular radial inward facing groove in which an inner annular floating seal assembly is secured also for radial displacement. A compliant seal is secured to the inner annular floating seal assembly. The outer annular floating seal assembly encapsulates the inner annular floating seal assembly which is made from a very low alpha material in order to reduce thermal stress.

  5. Normative acts management

    Directory of Open Access Journals (Sweden)

    Monica Ardeleanu

    2007-12-01

    Full Text Available The presence of the normative act amongst the formal law sources system is the result of the constructive activity of specialized bodies, designated by the Constitution, by laws or by regulations of normative power (having the right of drafting norms of generally mandatory power. Such bodies are named lawgiving bodies (also referred to as the "lawgiver" or "lawmaker" and they are first of all the bodies of the lawgiving power, entitled to issue on a primary and originator level the fundamental social relations in a society, to organize the juridical order of a nation or of a community of nations. The activity of these bodies is carried out under rules of juridical technique and in accordance with the general purposes imposed by the proper functioning of the social mechanism regarding the coexistence of social freedoms.

  6. Virtual Acts of Balance!

    DEFF Research Database (Denmark)

    Madsen, Anders Koed

    2013-01-01

    This paper presents an analysis of official documents and white papers pertaining to the two web-portals The Policy Grid Project and FEED that are launched by the UK and the EU respectively. The aim of the portals is to filter and synthesize information relevant for policy discussions and thereby...... Construction of Technology' and it shows how the framing of the portals and the concrete digital choices taken in relation to the infrastructure are influenced by the social intentions of relevant social groups as well as by the technical limitations on computers abilities to process semantic data....... It is especially emphasized how technical web-ontologies implicitly carries with them deeper philosophical ontologies about phanomena such as 'politic', 'scientific intentionality' and 'freedom'. The compromise between these technical influences and the social intentions is described as a 'virtual act of balance...

  7. 76 FR 74066 - Agency Forms Undergoing Paperwork Reduction Act Review

    Science.gov (United States)

    2011-11-30

    ... departments to build effective delivery systems for dissemination, implementation and evaluation of evidence based/best practice programs and policies. Core VIPP also focuses on the integration of unintentional... new Affordable Care Act (ACA) Maternal, Infant, and Early Childhood Home Visiting Program. The state...

  8. Will Early Retirement Retire Early?

    Science.gov (United States)

    Walker, James W.

    1976-01-01

    Management should recognize and consider both the advantages of early retirement programs and the countervailing forces of financial conditions, individual attitudes, and age discrimination laws. (Available from American Management Associations, Subscription Services, Box 319, Saranac Lake, NY 12983; $15.00 annually) (Author/MLF)

  9. Early discontinuation

    DEFF Research Database (Denmark)

    Hansen, Dorte Gilså; Felde, Lina; Gichangi, Anthony

    2007-01-01

    Introduction Discontinuation of medical drug treatment is a serious problem in primary care. The need for a better understanding of the processes, including physician-specific mechanisms, is apparent. The aim of this study was to analyse the association between general practitioners' prescribing....... There was a positive association between the prevalence of prescribing for the specific drugs studied (antidepressants, antidiabetics, drugs against osteoporosis and lipid-lowering drugs) and early discontinuation (r = 0.29 -0.44), but not for anti-hypertensive drugs. The analysis of the association between prevalence...... of all drugs and drug-specific early discontinuation showed some degree of positive association - strongest for anti-hypertensive drugs (r = 0.62) and antidepressants (r = 0.43). Conclusion This study confirmed our hypothesis that general practitioners with high levels of prescribing attain higher rates...

  10. Barnabas: Early Church leader and model of encouragement

    Directory of Open Access Journals (Sweden)

    R. G. Branch

    2007-07-01

    Full Text Available Acts presents Barnabas, an early church leader, as a model of integrity and character. It loads him with accolades. It calls him a good man (Acts 11:24, a prophet and teacher (Acts 13:1, an apostle (Acts 14:14, and one through whom God worked miracles (Acts 15:12. It recounts the times he faced persecution (Acts 13:45; 14:19 and risked his life for the name of the Lord Jesus Christ (Acts 15:26. He believed Saul truly had been converted (Acts 9:27 and saw the potential of John Mark (Acts 12:25 and championed them both at different times (Acts 11:25-26; 15:36-41. 1 Corinthians 9:6 affirms his charac- ter by noting he worked while serving congregations in order not to burden them. Acts introduces him as Joseph, a Levite from Cyprus, and praises his generous spirit (Acts 4:36. Arguably, Acts portrays no one else – except the Lord Jesus – in such glowing terms. The apostles nicknamed him Barnabas, Son of Encouragement, probably because he earned it!   Significantly, a passage relating the character attributes and big heartedness of Barnabas note that the disciples were called Christians first at Antioch (Acts 11:19-26. Because of its textual context, it may well be that the character traits of Barnabas defined the early use of the word Christian.   Barnabas played a decisive role in the Early Church. Yet over two millennia, he has slipped into unjustified obscurity behind Paul, Peter, John, and James, the brother of Jesus. This article examines selected stories about him that showcase his contributions to the Early Church and establish his significant leadership role.

  11. [Euthanasia and medical act].

    Science.gov (United States)

    2011-05-01

    Right to life -as the prohibition of intentionally and arbitrarily taking life, even with authorization of the concerned one- is an internationally recognized right. In many countries, debate regarding euthanasia is more centered in its convenience, social acceptability and how it is regulated, than in its substantial legitimacy. Some argue that euthanasia should be included as part of clinical practice of health professionals, grounded on individual's autonomy claims-everyone having the liberty to choose how to live and how to die. Against this, others sustain that life has a higher value than autonomy, exercising autonomy without respecting the right to life would become a serious moral and social problem. Likewise, euthanasia supporters some-times claim a 'right to live with dignity', which must be understood as a personal obligation, referred more to the ethical than to the strictly legal sphere. In countries where it is already legalized, euthanasia practice has extended to cases where it is not the patient who requests this but the family or some healthcare professional, or even the legal system-when they think that the patient is living in a condition which is not worthy to live. Generalization of euthanasia possibly will end in affecting those who need more care, such as elder, chronically ill or dying people, damaging severely personal basic rights. Nature, purpose and tradition of medicine rule out the practice of euthanasia, which ought not be considered a medical act or legitimately compulsory for physicians. Today's medicine counts with effective treatments for pain and suffering, such as palliative care, including sedative therapy, which best preserves persons dignity and keeps safe the ethos of the medical profession.

  12. 7 CFR 65.100 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Act. 65.100 Section 65.100 Agriculture Regulations of... MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) COUNTRY OF ORIGIN LABELING OF BEEF..., AND GINSENG General Provisions Definitions § 65.100 Act. Act means the Agricultural Marketing Act of...

  13. 78 FR 46256 - Privacy Act

    Science.gov (United States)

    2013-07-31

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION 11 CFR Part 1 Privacy Act CFR Correction In Title 11 of the Code of Federal Regulations, revised as... 1954.'' are added at the end of the definition of Act. BILLING CODE 1505-01-D ...

  14. Conversation electrified: ERP correlates of speech act recognition in underspecified utterances.

    Directory of Open Access Journals (Sweden)

    Rosa S Gisladottir

    Full Text Available The ability to recognize speech acts (verbal actions in conversation is critical for everyday interaction. However, utterances are often underspecified for the speech act they perform, requiring listeners to rely on the context to recognize the action. The goal of this study was to investigate the time-course of auditory speech act recognition in action-underspecified utterances and explore how sequential context (the prior action impacts this process. We hypothesized that speech acts are recognized early in the utterance to allow for quick transitions between turns in conversation. Event-related potentials (ERPs were recorded while participants listened to spoken dialogues and performed an action categorization task. The dialogues contained target utterances that each of which could deliver three distinct speech acts depending on the prior turn. The targets were identical across conditions, but differed in the type of speech act performed and how it fit into the larger action sequence. The ERP results show an early effect of action type, reflected by frontal positivities as early as 200 ms after target utterance onset. This indicates that speech act recognition begins early in the turn when the utterance has only been partially processed. Providing further support for early speech act recognition, actions in highly constraining contexts did not elicit an ERP effect to the utterance-final word. We take this to show that listeners can recognize the action before the final word through predictions at the speech act level. However, additional processing based on the complete utterance is required in more complex actions, as reflected by a posterior negativity at the final word when the speech act is in a less constraining context and a new action sequence is initiated. These findings demonstrate that sentence comprehension in conversational contexts crucially involves recognition of verbal action which begins as soon as it can.

  15. Conversation electrified: ERP correlates of speech act recognition in underspecified utterances.

    Science.gov (United States)

    Gisladottir, Rosa S; Chwilla, Dorothee J; Levinson, Stephen C

    2015-01-01

    The ability to recognize speech acts (verbal actions) in conversation is critical for everyday interaction. However, utterances are often underspecified for the speech act they perform, requiring listeners to rely on the context to recognize the action. The goal of this study was to investigate the time-course of auditory speech act recognition in action-underspecified utterances and explore how sequential context (the prior action) impacts this process. We hypothesized that speech acts are recognized early in the utterance to allow for quick transitions between turns in conversation. Event-related potentials (ERPs) were recorded while participants listened to spoken dialogues and performed an action categorization task. The dialogues contained target utterances that each of which could deliver three distinct speech acts depending on the prior turn. The targets were identical across conditions, but differed in the type of speech act performed and how it fit into the larger action sequence. The ERP results show an early effect of action type, reflected by frontal positivities as early as 200 ms after target utterance onset. This indicates that speech act recognition begins early in the turn when the utterance has only been partially processed. Providing further support for early speech act recognition, actions in highly constraining contexts did not elicit an ERP effect to the utterance-final word. We take this to show that listeners can recognize the action before the final word through predictions at the speech act level. However, additional processing based on the complete utterance is required in more complex actions, as reflected by a posterior negativity at the final word when the speech act is in a less constraining context and a new action sequence is initiated. These findings demonstrate that sentence comprehension in conversational contexts crucially involves recognition of verbal action which begins as soon as it can.

  16. VT Act 174 Wind Potential

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) The statewide wind potential layer used in the Act 174 effort represents three combined wind resource layers: Potential Residential and Small and...

  17. Endangered Species Act Critical Habitat

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Critical habitat (CH) is designated for the survival and recovery of species listed as threatened or endangered under the Endangered Species Act (ESA). Critical...

  18. The Iran Sanctions Act (ISA)

    National Research Council Canada - National Science Library

    Katzman, Kenneth

    2007-01-01

    ... (the Iran Freedom Support Act, P.L. 109-293) extended it until December 31, 2011, terminated application to Libya, and added provisions, although with substantial Administration flexibility in implementation...

  19. Bilingual Writing as an Act of Identity: Sign-Making in Multiple Scripts

    Science.gov (United States)

    Kabuto, Bobbie

    2010-01-01

    This article explores early bilingual script writing as an act of identity. Using multiple theoretical perspectives related to social semiotics and social constructivist perspectives on identity and writing, the research presented in this article is based on a case study of an early biliterate learner of Japanese and English from the ages of 3-7.…

  20. 7 CFR 35.1 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Act. 35.1 Section 35.1 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices... Definitions § 35.1 Act. Act or Export Grape and Plum Act means “An Act to promote the foreign trade of the...

  1. 7 CFR 922.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 922.2 Section 922.2 Agriculture Regulations of... WASHINGTON Order Regulating Handling Definitions § 922.2 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933), as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of...

  2. 7 CFR 948.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 948.2 Section 948.2 Agriculture Regulations of... Regulating Handling Definitions § 948.2 Act. Act means Public Act No. 10 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (sections 1-19, 48...

  3. 7 CFR 987.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 987.2 Section 987.2 Agriculture Regulations of... RIVERSIDE COUNTY, CALIFORNIA Order Regulating Handling Definitions § 987.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of...

  4. 7 CFR 981.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 981.2 Section 981.2 Agriculture Regulations of... Handling Definitions § 981.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48 Stat. 31, as amended...

  5. 7 CFR 984.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 984.2 Section 984.2 Agriculture Regulations of... Handling Definitions § 984.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (7 U.S.C. 601 et seq.). ...

  6. 7 CFR 915.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 915.2 Section 915.2 Agriculture Regulations of... Regulating Handling Definitions § 915.2 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933), as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48...

  7. 7 CFR 993.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 993.2 Section 993.2 Agriculture Regulations of... Regulating Handling Definitions § 993.2 Act. Act means Public Act No. 10, 73d Congress, as amended and reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (7 U.S.C. 601 et seq.). ...

  8. 7 CFR 932.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 932.2 Section 932.2 Agriculture Regulations of... Handling Definitions § 932.2 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933) as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48 Stat. 31...

  9. 7 CFR 925.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 925.2 Section 925.2 Agriculture Regulations of... SOUTHEASTERN CALIFORNIA Definitions § 925.2 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933), as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48...

  10. 7 CFR 1260.128 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1260.128 Section 1260.128 Agriculture... Promotion and Research Order Definitions § 1260.128 Act. Act means the Beef Promotion and Research Act of 1985, Title XVI, Subtitle A of the Food Security Act of 1985, Pub. L. 99-198 and any amendments thereto. ...

  11. 7 CFR 916.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 916.2 Section 916.2 Agriculture Regulations of... Regulating Handling Definitions § 916.2 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933), as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48...

  12. 7 CFR 927.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 927.2 Section 927.2 Agriculture Regulations of... Regulating Handling Definitions § 927.2 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933), as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48...

  13. 7 CFR 983.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 983.2 Section 983.2 Agriculture Regulations of... NEW MEXICO Definitions § 983.2 Act. Act means Public Act No. 10, 73rd Congress (May 12, 1933), as amended and as re-enacted and amended by the Agricultural Marketing Order Act of 1937, as amended (48 Stat...

  14. 7 CFR 906.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 906.2 Section 906.2 Agriculture Regulations of... GRANDE VALLEY IN TEXAS Order Regulating Handling Definitions § 906.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as re-enacted and amended by the Agricultural Marketing Agreement Act of...

  15. 7 CFR 917.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 917.2 Section 917.2 Agriculture Regulations of... Order Regulating Handling Definitions § 917.2 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933), as amended, and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as...

  16. 7 CFR 956.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 956.2 Section 956.2 Agriculture Regulations of... OF SOUTHEAST WASHINGTON AND NORTHEAST OREGON Definitions § 956.2 Act. Act means Public Act No. 10... Agreement Act of 1937, as amended (Sec. 1-19, 48 Stat. 31, as amended; 7 U.S.C. 601 et seq.). ...

  17. 7 CFR 923.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 923.2 Section 923.2 Agriculture Regulations of... IN WASHINGTON Order Regulating Handling Definitions § 923.2 Act. Act means Public Act No. 10, 73d... Act of 1937, as amended (48 Stat. 31, as amended; 7 U.S.C. 601 et seq.; 68 Stat. 906, 1047). ...

  18. 7 CFR 959.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 959.2 Section 959.2 Agriculture Regulations of... Handling Definitions § 959.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (sections 1-19, 48 Stat...

  19. 7 CFR 966.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 966.2 Section 966.2 Agriculture Regulations of... Handling Definitions § 966.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48 Stat. 31, as amended...

  20. 7 CFR 930.1 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 930.1 Section 930.1 Agriculture Regulations of... Definitions § 930.1 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933), as amended, and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48 Stat. 31, as...

  1. 7 CFR 982.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 982.2 Section 982.2 Agriculture Regulations of... Order Regulating Handling Definitions § 982.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (7 U.S.C...

  2. 7 CFR 989.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 989.2 Section 989.2 Agriculture Regulations of... CALIFORNIA Order Regulating Handling Definitions § 989.2 Act. Act means Public Act No. 10, 73d Congress, as amended, and as re-enacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended...

  3. 7 CFR 1170.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Act. 1170.2 Section 1170.2 Agriculture Regulations of... Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PRODUCT MANDATORY REPORTING § 1170.2 Act. Act means the Agricultural Marketing Act of 1946, 7 U.S.C. 1621 et seq., as amended by the Dairy Market Enhancement Act of...

  4. 7 CFR 946.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 946.2 Section 946.2 Agriculture Regulations of... Regulating Handling Definitions § 946.2 Act. Act means Public Act No. 10, 73d Congress, as amended and reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48 Stat. 31, as...

  5. Indução do parto de bovinos aos 270 dias de gestação com a utilização prévia de glicocorticoide de longa ação e a transferência de imunidade passiva = Inducing bovine parturition at 270 pregnancy days with early use of a long-acting glucocorticoid and passive immunity transfer

    Directory of Open Access Journals (Sweden)

    Alfredo Quites Antoniazzi

    2009-01-01

    Full Text Available O trabalho teve por objetivo avaliar a taxa de transferência de imunidade passiva e de retenção de placenta com a utilização prévia de um glicocorticoide de longa ação na indução do parto bovino aos 270 dias de gestação, bem como verificar a eficácia dos protocolos. Foram utilizadas 42 vacas prenhes, de corte e de leite, leatoriamente separadas em três grupos: Grupo-controle (C que não recebeu aplicação hormonal, mas o mesmo manejo; Grupo longa ação + indução (LA que recebeu 30 mg de acetato de metilprednisolona, via subcutânea, no dia 255 de gestação e 20 mg de dexametasona associada a 0,5 mg de cloprostenol sódico, via intramuscular, no dia 270 de gestação; e Grupo indução (I que recebeu 20 mg de dexametasona associada a 0,5 mg de cloprostenol sódico no dia 270 de gestação. A utilização prévia do glicocorticoide de longa ação não mostrou diferença na taxa de transferência de imunidade passiva e nos índices de retenção de placenta. As fêmeas dos Grupos LA e I pariram em 41,36 ± 1,89h após a aplicação hormonal de dexametasona associada ao cloprostenol, independente de aplicação prévia de glicocorticoide de longa ação no Grupo LA. A indução da parição com dexametasonaassociada ao cloprostenol, independente da aplicação prévia de acetato de metilprednisolona, mostrou-se eficaz em todos dos animais.This experiment had the objective of evaluating passive immunity transfer and placental retention rates with the early use of a long-acting glucocorticoid to induce bovine parturition at 270 pregnancy days, as well as comparing protocol efficacy regarding the timing of parturition induction. Fortytwo pregnant cows were selected from a beef and dairy herd and randomly assigned into one of three groups: control (C without drug injection, but with the same management; long-acting + induction group (LA, with one injection of 30 mg prednisolone methylacetate, subcutaneous, on pregnancy day 255 and

  6. Early Intervention for Families and Children Experiencing Homelessness

    Science.gov (United States)

    Hurley, Jennifer J.; Looby, Winnie; Goodrum, Ashley R.; Campbell, Elizabeth M.; Bonti, Gregg K.; Raymon, Becca A.; Condon, Rebecca; Schwaeber, Sami E.; Mauceri, Melina E.; Bourne, Erin M.; Callahan, Elizabeth D.; Hardy, Danielle L.; Mathews, Pamela

    2018-01-01

    Early intervention (EI) services are provided for families and children at risk for or with developmental delays. Early intervention includes services that are provided in the natural environment as mandated by the Individuals with Disabilities Education Act (IDEA; 2004). The natural environment is where children and families would naturally spend…

  7. Developing Prosocial Behaviors in Early Adolescence with Reactive Aggression

    Science.gov (United States)

    Fung, Annis L. C.

    2008-01-01

    Despite the alarming rise of early adolescence aggression in Hong Kong, it is the pioneer evidence-based outcome study on Anger Coping Training (ACT) program for early adolescence with reactive aggression to develop their prosocial behaviors. This research program involved experimental and control groups with pre- and post-comparison using a …

  8. 7 CFR 33.1 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Act. 33.1 Section 33.1 Agriculture Regulations of the... AUTHORITY OF THE EXPORT APPLE ACT Definitions § 33.1 Act. Act and Export Apple Act are synonymous and mean “An act to promote the foreign trade of the United States in apples to protect the reputation of...

  9. Sport supporting act: terminology issues

    Directory of Open Access Journals (Sweden)

    Petr Vlček

    2013-01-01

    Full Text Available BACKGROUND: The text deals with terminology issues from an interdisciplinary point of view. It is based on two different disciplines, law and kinanthropology, in an area of their overlap. AIM: The aim of the author is to point out some possible legislative problems, which could arise due to the current reading of the sport supporting act (Act no. 115/2001. The second aim of the author is to contribute to the discussion of kinantropologists (possibly also the educational researchers and lawyers and to stress the importance of the systematic approach to terminology formulation. METHODS: The author uses the method of language interpretation. We also use the basic analytical methods, induction and deduction, while we stress the systematic approach to the term formulation. RESULTS: The analysis of the sport supporting act terminology shows some specific legislative problems, which could arise due to the definition of sport in the sport supporting act. The author discusses a possible alternative solution. CONCLUSION: According to the opinion of the author, clear, obvious and unified terminology of kinantropologists as specialists in their discipline should represent a source, from which other sciences could derive their terminology. Defined and inexpert terminology used in other disciplines should not be used as an argument for its adopting in kinanthropology.

  10. Indirect speech acts in English

    OpenAIRE

    Василина, Владимир Николаевич

    2013-01-01

    The article deals with indirect speech acts in Englishspeaking discourse. Different approaches to their analysis and the reasons for their use are discussed. It is argued that the choice of the form of speech actsdepends on the parameters of communicative partners.

  11. Paraconsistent semantics of speech acts

    NARCIS (Netherlands)

    Dunin-Kȩplicz, Barbara; Strachocka, Alina; Szałas, Andrzej; Verbrugge, Rineke

    2015-01-01

    This paper discusses an implementation of four speech acts: assert, concede, request and challenge in a paraconsistent framework. A natural four-valued model of interaction yields multiple new cognitive situations. They are analyzed in the context of communicative relations, which partially replace

  12. The Ontogenesis of Speech Acts

    Science.gov (United States)

    Bruner, Jerome S.

    1975-01-01

    A speech act approach to the transition from pre-linguistic to linguistic communication is adopted in order to consider language in relation to behavior and to allow for an emphasis on the use, rather than the form, of language. A pilot study of mothers and infants is discussed. (Author/RM)

  13. IAS IN SPEECH ACT STUDIES

    African Journals Online (AJOL)

    they offer into the way in which cultural differences are encoded in speech act performance, has important implica- tions for first and second language teaching in linguistically and culturally diverse societies. A brief look at some of ..... or not to use slang, etc. The question, then, is whether and to what extent the rela- tionship.

  14. Acting against one's best judgement

    NARCIS (Netherlands)

    Peijnenburg, Adriana Johanna Maria

    1996-01-01

    Handelen tegen beter weten in (Acting Against One’s Best Judgment) heeft als ondertitel Een onderzoek naar praktisch redeneren, disposities en wilszwakte. De laatste term is daarbij cruciaal. Wat is wilszwakte - in het oud-Grieks akrasia of akrateia - en hoe valt het te verklaren? Wat gebeurt er

  15. Acting White: A Critical Review

    Science.gov (United States)

    Sohn, Kitae

    2011-01-01

    The hypothesis of acting White has been heatedly debated and influential over the last 20 years or so in explaining the Black-White test score gap. Recently, economists have joined the debate and started providing new theoretical and empirical analyses of the phenomenon. This paper critically reviews the arguments that have been advanced to…

  16. 7 CFR 1230.601 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1230.601 Section 1230.601 Agriculture... CONSUMER INFORMATION Procedures for the Conduct of Referendum Definitions § 1230.601 Act. The term Act means the Pork Promotion, Research, and Consumer Information Act of 1985 (7 U.S.C. 4801-4819) and any...

  17. 7 CFR 1206.1 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1206.1 Section 1206.1 Agriculture Regulations of... Mango Promotion, Research, and Information Order Definitions § 1206.1 Act. Act means the Commodity Promotion, Research, and Information Act of 1996 (7 U.S.C. 7411-7425; Public Law 104-127; 110 Stat. 1029...

  18. 7 CFR 1220.101 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1220.101 Section 1220.101 Agriculture... CONSUMER INFORMATION Soybean Promotion and Research Order Definitions § 1220.101 Act. The term Act means the Soybean Promotion, Research, and Consumer Information Act, subtitle E of title XIX, of the Food...

  19. 7 CFR 1219.1 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1219.1 Section 1219.1 Agriculture Regulations of... INFORMATION Hass Avocado Promotion, Research, and Information Order Definitions § 1219.1 Act. Act means the Hass Avocado Promotion, Research, and Information Act of 2000, Public Law 106-387, 7 U.S.C. 7801-7813...

  20. 7 CFR 1280.101 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1280.101 Section 1280.101 Agriculture... INFORMATION ORDER Lamb Promotion, Research, and Information Order Definitions § 1280.101 Act. Act means the Commodity Promotion, Research, and Information Act of 1996 (7 U.S.C. 7411-7425; Pub. L. 104-127; 110 Stat...

  1. 7 CFR 1250.302 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1250.302 Section 1250.302 Agriculture... Research and Promotion Order Definitions § 1250.302 Act. Act means the Egg Research and Consumer Information Act and as it may be amended (Pub. L. 93-428). ...

  2. 7 CFR 958.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 958.2 Section 958.2 Agriculture Regulations of... IN IDAHO, AND MALHEUR COUNTY, OREGON Order Regulating Handling Definitions § 958.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing...

  3. 22 CFR 901.10 - Act.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Act. 901.10 Section 901.10 Foreign Relations FOREIGN SERVICE GRIEVANCE BOARD GENERAL Meanings of Terms As Used in This Chapter § 901.10 Act. Act means the Foreign Service Act of 1980 (Pub. L. 96-465, October 17, 1980), as amended. ...

  4. 7 CFR 1218.1 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1218.1 Section 1218.1 Agriculture Regulations of... INFORMATION ORDER Blueberry Promotion, Research, and Information Order Definitions § 1218.1 Act. Act means the Commodity Promotion, Research, and Information Act of 1996 (7 U.S.C. 7401-7425; Pub. L. 104-127; 110 Stat...

  5. 7 CFR 945.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 945.2 Section 945.2 Agriculture Regulations of... COUNTIES IN IDAHO, AND MALHEUR COUNTY, OREGON Order Regulating Handling Definitions § 945.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing...

  6. 34 CFR 300.4 - Act.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Act. 300.4 Section 300.4 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES... Definitions Used in This Part § 300.4 Act. Act means the Individuals with Disabilities Education Act, as...

  7. 7 CFR 926.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 926.2 Section 926.2 Agriculture Regulations of... REQUIREMENTS APPLICABLE TO CRANBERRIES NOT SUBJECT TO THE CRANBERRY MARKETING ORDER § 926.2 Act. Act means Public Act No. 10, 73d Congress , as amended, and as reenacted and amended by the Agricultural Marketing...

  8. 25 CFR 700.103 - Uniform Act.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Uniform Act. 700.103 Section 700.103 Indians THE OFFICE... and Instructions Definitions § 700.103 Uniform Act. The term Uniform Act means the Uniform Relocation Assistance and Real Property Acquisition Policies Act of 1970 (84 Stat. 1894; 42 U.S.C. 4601 et seq.; Pub. L...

  9. 7 CFR 1221.1 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1221.1 Section 1221.1 Agriculture Regulations of... INFORMATION ORDER Sorghum Promotion, Research, and Information Order Definitions § 1221.1 Act. Act means the Commodity Promotion, Research, and Information Act of 1996 (7 U.S.C. 7411-7425), and any amendments thereto. ...

  10. 7 CFR 1230.1 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1230.1 Section 1230.1 Agriculture Regulations of... INFORMATION Pork Promotion, Research, and Consumer Information Order Definitions § 1230.1 Act. Act means the Pork Promotion, Research, and Consumer Information Act of 1985 (7 U.S.C. 4801-4819) and any amendments...

  11. 7 CFR 985.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 985.2 Section 985.2 Agriculture Regulations of... SPEARMINT OIL PRODUCED IN THE FAR WEST Order Regulating Handling Definitions § 985.2 Act. Act means Public Act No. 10, 73d Congress, as amended, and reenacted and amended by the Agricultural Marketing...

  12. 7 CFR 1205.302 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1205.302 Section 1205.302 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Research and Promotion Order Definitions § 1205.302 Act. Act means the Cotton Research and Promotion Act...

  13. 7 CFR 1210.302 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1210.302 Section 1210.302 Agriculture... PLAN Watermelon Research and Promotion Plan Definitions § 1210.302 Act. Act means the Watermelon Research and Promotion Act of 1985 (Title XVI, Subtitle C of Pub. L. 99-198, 99th Congress, effective...

  14. 34 CFR 303.6 - Act.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Act. 303.6 Section 303.6 Education Regulations of the..., Eligibility, and Other General Provisions § 303.6 Act. As used in this part, Act means the Individuals with Disabilities Education Act. (Authority: 20 U.S.C. 1400) ...

  15. 7 CFR 1216.1 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1216.1 Section 1216.1 Agriculture Regulations of... ORDER Peanut Promotion, Research, and Information Order Definitions § 1216.1 Act. Act means the Commodity Promotion, Research, and Information Act of 1996 (7 U.S.C. 7401-7425; Public Law 104-127, 110 Stat...

  16. 7 CFR 1212.1 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1212.1 Section 1212.1 Agriculture Regulations of..., Consumer Education, and Industry Information Order Definitions § 1212.1 Act. “Act” means the Commodity Promotion, Research, and Information Act of 1996, (7 U.S.C. 7411-7425), and any amendments to that Act. ...

  17. 40 CFR 1508.2 - Act.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Act. 1508.2 Section 1508.2 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY TERMINOLOGY AND INDEX § 1508.2 Act. Act means the National Environmental Policy Act, as amended (42 U.S.C. 4321, et seq.) which is also referred to as “NEPA.” ...

  18. 7 CFR 924.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 924.2 Section 924.2 Agriculture Regulations of... WASHINGTON AND IN UMATILLA COUNTY, OREGON Order Regulating Handling Definitions § 924.2 Act. Act means Public Act No. 10, 73d Congress (May 12, 1933), as amended and as re-enacted and amended by the Agricultural...

  19. 7 CFR 1215.1 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1215.1 Section 1215.1 Agriculture Regulations of... INFORMATION Popcorn Promotion, Research, and Consumer Information Order Definitions § 1215.1 Act. Act means the Popcorn Promotion, Research, and Consumer Information Act of 1995, Subtitle E of Title V of the...

  20. 7 CFR 1207.302 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1207.302 Section 1207.302 Agriculture... Potato Research and Promotion Plan Definitions § 1207.302 Act. Act means the Potato Research and Promotion Act, Title III of Public Law 91-670, 91st Congress, approved January 11, 1971, 84 Stat. 2041, as...

  1. 29 CFR 401.17 - Act.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Act. 401.17 Section 401.17 Labor Regulations Relating to Labor OFFICE OF LABOR-MANAGEMENT STANDARDS, DEPARTMENT OF LABOR LABOR-MANAGEMENT STANDARDS MEANING OF TERMS USED IN THIS SUBCHAPTER § 401.17 Act. Act means the Labor-Management Reporting and Disclosure Act...

  2. 7 CFR 1205.10 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1205.10 Section 1205.10 Agriculture Regulations... for Conduct of Sign-up Period Definitions § 1205.10 Act. The term Act means the Cotton Research and Promotion Act, as amended . ...

  3. 12 CFR 541.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Act. 541.2 Section 541.2 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY DEFINITIONS FOR REGULATIONS AFFECTING FEDERAL SAVINGS ASSOCIATIONS § 541.2 Act. The term Act means the Home Owners' Loan Act of 1933, as amended. ...

  4. 7 CFR 1150.101 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Act. 1150.101 Section 1150.101 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Definitions § 1150.101 Act. Act means Title I, Subtitle B, of the Dairy and Tobacco Adjustment Act of 1983...

  5. 76 FR 25665 - No Fear Act

    Science.gov (United States)

    2011-05-05

    ... COMMISSION No Fear Act AGENCY: American Battle Monuments Commission. ACTION: Notice. SUMMARY: The American... FEAR Act), as implemented by the Office of Personnel Management (OPM) regulations at 5 CFR part 724... Retaliation Act of 2002,'' which is now known as the No FEAR Act. See Public Law 107-174, codified at 5 U.S.C...

  6. [Suicide, a philosophical act or an act of depression?].

    Science.gov (United States)

    Heslon, Christian

    2016-01-01

    Suicide is more frequent in people aged over 75 than in the rest of the population. Is it the fact of feeling too old or of being alone? Is the person fully lucid? The question of responsibility is raised, as is the meaning of the act: the ultimate living gesture or capitulation in the face of death? Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  7. 7 CFR 929.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 929.2 Section 929.2 Agriculture Regulations of... ISLAND IN THE STATE OF NEW YORK Order Regulating Handling Definitions § 929.2 Act. Act means Public Act... Marketing Agreement Act of 1937, as amended (secs. 1-19, 48 Stat. 31, as amended; 7 U.S.C. 601-674). ...

  8. 7 CFR 905.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 905.2 Section 905.2 Agriculture Regulations of... TANGELOS GROWN IN FLORIDA Order Regulating Handling Definitions § 905.2 Act. Act means Public Act No. 10... Agreement Act of 1937, as amended. (48 Stat. 31, as amended; 7 U.S.C. 601 et seq.; 68 Stat. 906, 1047.) ...

  9. 7 CFR 1160.101 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Act. 1160.101 Section 1160.101 Agriculture Regulations... Definitions § 1160.101 Act. Act means the Fluid Milk Promotion Act of 1990, Subtitle H of Title XIX of the Food, Agriculture, Conservation, and Trade Act of 1990, Public Law 101-624, 7 U.S.C. 6401-6417, and any...

  10. 7 CFR 947.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 947.2 Section 947.2 Agriculture Regulations of... Definitions § 947.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as reenacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (48 Stat. 31, as amended; 7 U.S.C. 601 et...

  11. 29 CFR 4.103 - The Act.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true The Act. 4.103 Section 4.103 Labor Office of the Secretary... Contract Act Introductory § 4.103 The Act. The McNamara-O'Hara Service Contract Act of 1965 (Pub. L. 89-286, 79 Stat. 1034, 41 U.S.C. 351 et seq.), hereinafter referred to as the Act, was approved by the...

  12. 7 CFR 953.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Act. 953.2 Section 953.2 Agriculture Regulations of... Order Regulating Handling Definitions § 953.2 Act. Act means Public Act No. 10, 73d Congress, as amended and as re-enacted and amended by the Agricultural Marketing Agreement Act of 1937, as amended (7 U.S.C...

  13. Structural construction of law enforcement acts

    OpenAIRE

    Пунько, Оксана Віталіївна

    2014-01-01

    The article investigates the problematic issue of structural construction of law enforcement acts, its components, internal and external form of construction. The task of this article is outlining the theoretical position of structural construction of law enforcement acts.  Law enforcement act is the legal result of law enforcement activities. These acts are fixed, issued decisions that were taken in law enforcement activity. Analysis of law enforcement practices shows that most acts are iss...

  14. Long-acting muscarinic antagonists

    DEFF Research Database (Denmark)

    Busse, William W; Dahl, Ronald; Jenkins, Christine

    2016-01-01

    -acting anticholinergics as bronchodilators in the treatment of asthma, with results published from clinical trials of glycopyrrolate, umeclidinium and tiotropium. The tiotropium clinical trial programme is the most advanced, with data available from a number of phase II and III studies of tiotropium as an add......-on to inhaled corticosteroid maintenance therapy, with or without a long-acting β2-agonist, in patients across asthma severities. Recent studies using the Respimat Soft Mist inhaler have identified 5 µg once daily as the preferred dosing regimen, which has shown promising results in adults, adolescents...... and children with asthma. Tiotropium Respimat has recently been incorporated into the Global Initiative for Asthma 2015 treatment strategy as a recommended alternative therapy at steps 4 and 5 in adult patients with a history of exacerbations. The increasing availability of evidence from ongoing and future...

  15. From Speech Acts to Semantics

    Directory of Open Access Journals (Sweden)

    Mackenzie Jim

    2014-03-01

    Full Text Available Frege introduced the notion of pragmatic force as what distinguishes statements from questions. This distinction was elaborated by Wittgenstein in his later works, and systematised as an account of different kinds of speech acts in formal dialogue theory by Hamblin. It lies at the heart of the inferential semantics more recently developed by Brandom. The present paper attempts to sketch some of the relations between these developments.

  16. Clean Air Act. Revision 5

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-15

    This Reference Book contains a current copy of the Clean Air Act, as amended, and those regulations that implement the statute and appear to be most relevant to DOE activities. The document is provided to DOE and contractor staff for informational purposes only and should not be interpreted as legal guidance. This Reference Book has been completely revised and is current through February 15, 1994.

  17. SCADA Application for ACTS Technology

    Science.gov (United States)

    Fairbanks, Barry

    1992-01-01

    The results of a system level study done by Hughes Network Systems for NASA are presented. For the supervisory control and data acquisition (SCADA) application, use of Ka-band spot beam satellite technology associated with NASA's Advanced Communication Technology Satellite (ACTS) offers a reduction in Earth station antenna size and transmitter power that may translate into lower system costs. The approaches taken to determine commercial potential of the system are described.

  18. Long acting methods of contraception.

    Science.gov (United States)

    Newton, J

    1993-01-01

    Long acting methods of contraception have been developed and refined over the last 10 years. From the classical long acting progestogen-only depot preparations we now have a range of delivery systems including both combined and progestogen only injection systems and vaginal rings also containing either progestogen only or oestrogen and progestogen in combination. Subcutaneous implants at present containing only a progestogen, offer a range of durations from 2-5 years. The efficacy of these methods is high, with failure rates as low as 0.1 per 100 woman years. However, with progestogen only systems a significant proportion of women develop unpredictable menstrual bleeding, which with counselling is acceptable. The commonest reason for discontinuation still remains menstrual disorders and recent WHO workshops have investigated the cause of this bleeding and refined the reference periods of analysis. The method of action of progestogen-only systems is primarily cervical mucus blockade and prevention of sperm penetration. However, they also tend to produce a thinned atrophic endometrium. Ovarian effects ranging from complete anovulation to disordered luteal phase, persistent follicles and disorganised hormone production add to the contraceptive effect in more than half of the treatment cycles, but cause some of the menstrual disturbance. All these long acting methods are essential to family planning programmes, offering highly acceptable, and in some cases novel methods with high efficacy.

  19. Preventing Obesity Across Generations: Evidence for Early Life Intervention.

    Science.gov (United States)

    Haire-Joshu, Debra; Tabak, Rachel

    2016-01-01

    To prevent the intergenerational transfer of obesity and end the current epidemic, interventions are needed across the early life stages, from preconception to prenatal to infancy through the age of 2 years. The foundation for obesity is laid in early life by actions and interactions passed from parent to child that have long-lasting biologic and behavioral consequences. The purpose of this paper is to examine the best evidence about (a) factors in parents and offspring that promote obesity during the early life stages, (b) the social determinants and dimensions of obesity in early life, (c) promising and effective interventions for preventing obesity in early life, and (d) opportunities for future research into strategies to disrupt the intergenerational cycle of obesity that begins early in life. The pathway for halting the intergenerational obesity epidemic requires the discovery and development of evidence-based interventions that can act across multiple dimensions of influence on early life.

  20. 30th anniversary of the 1967 Abortion Act. UK news.

    Science.gov (United States)

    1998-01-01

    On the 30th anniversary of the 1967 Abortion Act, October 27, 1997, Lord David Steel of Aikwood KBE, architect of the Act, reminded people that whatever one thinks about abortion, if it is going to happen, it's better that it be safe and legal than illegal and dangerous. The event received extensive coverage by the press and broadcast media which mostly discussed abortion as a necessary and legitimate part of reproductive health care, rather than as a controversial moral issue. Many of the articles and broadcasts were based upon material from two pro-choice books published to mark the anniversary: "Voices for Change" (by the National Abortion Campaign and Marie Stopes International) and "Abortion Law Reformers: Pioneers of Change" (by Birth Control Trust). One Parliamentary Early Day Motion (EDM) commemorated the Act and its benefits for women, while another called for the Act to be liberalized and extended to Northern Ireland. The anti-choice lobby argues that Britain has elected the most pro-choice parliament in its history. The major UK anti-choice groups had little public impact, with the Catholic Church voicing the most significant opposition to legal abortion.

  1. PICKLE acts during germination to repress expression of embryonic traits

    Science.gov (United States)

    Li, Hui-Chun; Chuang, King; Henderson, James T.; Rider, Stanley Dean; Bai, Yinglin; Zhang, Heng; Fountain, Matthew; Gerber, Jacob; Ogas, Joe

    2008-01-01

    SUMMARY PICKLE (PKL) codes for a CHD3 chromatin remodeling factor that plays multiple roles in Arabidopsis growth and development. Previous analysis of the expression of genes that exhibit PKL-dependent regulation suggested that PKL acts during germination to repress expression of embryonic traits. In this study, we examined the expression of PKL protein to investigate when and where PKL acts to regulate development. A PKL:eGFP translational fusion is preferentially localized in the nucleus of cells, consistent with the proposed role for PKL as a chromatin remodeling factor. A steroid-inducible version of PKL - a fusion of PKL to the glucocorticoid receptor (PKL:GR) - was used to examine when PKL acts to repress expression of embryonic traits. We found that activation of PKL:GR during germination was sufficient to repress expression of embryonic traits in the primary roots of pkl seedlings whereas activation of PKL:GR after germination had little effect. In contrast, we observed that PKL is required continuously after germination to repress expression of PHERES1, a type I MADS box gene that is normally expressed during early embryogenesis in wild-type plants. Thus PKL acts at multiple points during development to regulate patterns of gene expression in Arabidopsis. PMID:16359393

  2. Activin A accelerates the progression of fetal oocytes throughout meiosis and early oogenesis in the mouse.

    Science.gov (United States)

    Liang, Gui-Jin; Zhang, Xi-Feng; Wang, Jun-Jie; Sun, Yuan-Chao; Sun, Xiao-Feng; Cheng, Shun-Feng; Li, Lan; De Felici, Massimo; Shen, Wei

    2015-10-15

    Activins can exert several roles in ovary development. However, little is known about their involvement in early mammalian oogenesis. In this study, we reported that activin receptors (including ActRIA, ActRIB, ActRIIA, and ActRIIB) are expressed throughout the development of the mouse ovaries from 12.5 days postcoitum (dpc) to 21 days postparturition (dpp). Moreover, we found that in vitro, the addition of activin A (ActA) to the culture medium of 12.5 dpc ovarian tissues accelerated the progression of oocytes throughout meiotic prophase I stages. This result was reproduced in vivo following administration of ActA to pregnant mice. The in vitro effect of ActA was associated with increased expression of premeiotic and meiotic genes (including Dazl, Spo11, Stra8, Scp3, and Rec8) in the ovarian tissues. Mechanistically, ActA-dependent SMAD3 signaling modulated the expression of members of the retinoic acid (RA) system, including the RA degradation CYP26B1 enzyme and the RA receptors. Finally, ActA promoted the survival and growth of fetal and early postnatal oocytes and primordial follicle assembly both in vitro and in vivo. In conclusion, the present study identifies new roles of ActA in early oogenesis and suggested that ActA and RA might cooperate in promoting meiosis in female germ cells.

  3. Modification as a propositional act

    DEFF Research Database (Denmark)

    Rijkhoff, Jan

    2014-01-01

    A complete functional theory of grammar should be able to specify the communicative function of each constituent in a sentence (or rather ‘Discourse Act’). Whereas predicating and referring have been given due attention in functional approaches to grammar, the modifying function of linguistic...... material in a Discourse Act has been largely ignored. This chapter argues (i) that modifying is no less actional than predicating or referring in the process of verbal communication and (ii) that the modifying function of linguistic material should be specified at the highest level of representation...

  4. Preventive Care Benefits (Affordable Care Act)

    Science.gov (United States)

    ... For children Footer Resources About the Affordable Care Act Regulatory and Policy Information For Navigators, Assisters & Partners ... gov USA.gov Resources About the Affordable Care Act Regulatory and Policy Information For Navigators, Assisters & Partners ...

  5. Speech Act Theory and Business Communication Conventions.

    Science.gov (United States)

    Ewald, Helen Rothschild; Stine, Donna

    1983-01-01

    Applies speech act theory to business writing to determine why certain letters and memos succeed while others fail. Specifically, shows how speech act theorist H. P. Grice's rules or maxims illuminate the writing process in business communication. (PD)

  6. Clean Water Act Section 404 and Agriculture

    Science.gov (United States)

    The U.S. Department of Agriculture (USDA) and EPA have longstanding programs to promote water quality and broader environmental goals identified in both the Agriculture Act of 2014 and the Clean Water Act.

  7. Misdiagnosed inmate to get trial under Rehabilitation Act claim.

    Science.gov (United States)

    1995-08-11

    A Federal judge dismissed most portions of a lawsuit filed by a prison inmate who was misdiagnosed with AIDS, but will send to trial his claim that his segregation to a special prison AIDS unit violated Section 504 of the Federal Rehabilitation Act. The Rehabilitation Act prohibits federally-funded state programs from discriminating against an individual on the basis of disability. A lab report on a biopsy of the inmate's skin lesions concluded that the lesions were consistent with early Kaposi's Sarcoma (KS), common among persons with AIDS. [Name removed], an inmate of the Green Haven Correctional Facility in Stormville, NY, was sent to the AIDS unit without being tested for HIV. He filed a grievance, and was tested five months after entering the unit. He tested negative for HIV and KS. The judge rejected [name removed] claims that he was denied procedural due process, but found that he qualified as a handicapped individual, entitled to Federal protection against discrimination.

  8. 34 CFR 5.1 - Act.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Act. 5.1 Section 5.1 Education Office of the Secretary...-10) Definitions § 5.1 Act. As used in this part, Act means section 552 of title 5, United States Code, as amended by Pub. L. 90-23, codifying the Act of July 4, 1966, sometimes referred to as the “Freedom...

  9. Allegheny County Clean Indoor Air Act Exemptions

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — List and location of all the businesses and social clubs who have received an exemption from the Pennsylvania Clean Indoor Air Act. “The Clean Indoor Air Act, Act...

  10. The 2014 Budget Act: Selected Legal Aspects

    Directory of Open Access Journals (Sweden)

    Andrzej Borodo

    2014-03-01

    Full Text Available The Budget Act for the year 2014 raises legal questions in the context of the provisions of the Constitution as well as the Public Finance Act from 2009. Polish constitutional provisions relating to the state budget may be described as too general. They specify the requirements with regard to the Budget Act only to a limited extent.

  11. Academic Development Is a Creative Act

    Science.gov (United States)

    Budge, Kylie; Clarke, Angela

    2012-01-01

    This paper argues that academic development is a creative act. Creative acts have potential to inspire, critique, inform and in many cases to change. The creativity literature identifies a number of core features of creative acts that assist in developing independent creative practitioners. Those features are observing, attending to relationships,…

  12. 12 CFR 619.9000 - The Act.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false The Act. 619.9000 Section 619.9000 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM DEFINITIONS § 619.9000 The Act. The Farm Credit Act of 1971; Pub. L. 92-181 and amendments. ...

  13. TANZANIA'S 2002 RECORDS AND ARCHIVES MANAGEMENT ACT

    African Journals Online (AJOL)

    The paper critically assesses the strengths and weaknesses of the Tanzania's Records and Archives Management Act of 2002. The Act repeals the 1931 Records Disposal Ordinance 9 (Cap.9), the 1965 National Archives Act no. 33 and the Presidential Circular no.7 of 1963 on the Care and Disposal of Public Records.

  14. 29 CFR 1614.203 - Rehabilitation Act.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Rehabilitation Act. 1614.203 Section 1614.203 Labor... EMPLOYMENT OPPORTUNITY Provisions Applicable to Particular Complaints § 1614.203 Rehabilitation Act. (a... Rehabilitation Act of 1973, as amended (29 U.S.C. 791), has been violated in a complaint alleging nonaffirmative...

  15. 31 CFR 0.216 - Privacy Act.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Privacy Act. 0.216 Section 0.216... RULES OF CONDUCT Rules of Conduct § 0.216 Privacy Act. Employees involved in the design, development, operation, or maintenance of any system of records or in maintaining records subject to the Privacy Act of...

  16. 12 CFR 268.203 - Rehabilitation Act.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Rehabilitation Act. 268.203 Section 268.203... Rehabilitation Act. (a) Model employer. The Board shall be a model employer of individuals with disabilities. The... Rehabilitation Act of 1973, as amended (29 U.S.C. 791), has been violated in a complaint alleging nonaffirmative...

  17. 7 CFR 29.13 - The act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false The act. 29.13 Section 29.13 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Definitions § 29.13 The act. The Tobacco Inspection Act, approved August 23, 1935. (7...

  18. 3 CFR - The Endangered Species Act

    Science.gov (United States)

    2010-01-01

    ... 3 The President 1 2010-01-01 2010-01-01 false The Endangered Species Act Presidential Documents Other Presidential Documents Memorandum of March 3, 2009 The Endangered Species Act Memorandum for the Heads of Executive Departments and Agencies The Endangered Species Act (ESA), 16 U.S.C. 1531 et seq...

  19. 3 CFR - Freedom of Information Act

    Science.gov (United States)

    2010-01-01

    ... 3 The President 1 2010-01-01 2010-01-01 false Freedom of Information Act Presidential Documents Other Presidential Documents Memorandum of January 21, 2009 Freedom of Information Act Memorandum for... disinfectants.” In our democracy, the Freedom of Information Act (FOIA), which encourages accountability through...

  20. Uproar over Milk Substitutes Act.

    Science.gov (United States)

    1993-11-15

    Health policy activists lobbied 7 years for the Infant Milk Substitutes, Feeding Bottles and Infant Food Bill. Proponents of the bill say that it basically curtails unethical marketing practices, not the sales of baby foods, and argue that it was conceived to reduce the trend of mothers over-diluting commercial milk in order to reduce household expenses as well as stem the potential erosion of knowledge on locally available weaning foods. Even though the bill will become an Act only after its rules and regulations have been finalized, the government has already banned baby food advertisements on television and in other electronic media under its control. Women's groups now argue that the bill tends to focus almost exclusively upon the welfare of children and compromises the position of women who can not lactate adequately. Moreover, they hold that the bill may be used to compel wives to stay out of the formal workforce so that they may feed their babies. The intention of the bill may be meaningless without complementary legislation addressing the problems of working mothers. Specifically, amendments to the Maternity Benefits Act of 1961 would extend maternity leave to 4 months after delivery and lengthen the duration of nursing breaks. It is, however, feared that these changes may reduce employment prospects for women.

  1. Women, motherhood and early childhood

    DEFF Research Database (Denmark)

    Ravnbøl, Camilla Ida

    This paper explores the question of how Roma women’s situation influences Roma children’s survival, growth and development in the early years. It focuses specifically on the barriers and opportunities for action that Roma women experience and how these influence their possibilities to engage in e...... an assessment of the mothers’ capacity to internalize and act upon advice. It is argued that supporting Roma women’s access to human rights is likely to have positive outcomes for the women and their families, especially the young children...... in efforts for their young children. The paper adopts the perspective that in poor and socially excluded Roma communities, young children’s survival, growth and development cannot be addressed effectively if the rights of women are overlooked. Roma women navigate in contexts where they, as women, experience...

  2. Gender and Early Warning

    OpenAIRE

    Schmeidl, Susanne

    2016-01-01

    This paper argues that the introduction of gender into early warning will lead to more practical, realistic and usable early warning approaches, especially if early warning is understood as a flexible system that is sensitive to the diverse situations or on the ground necessitating customised solution. A gender-sensitive approach can enhance early warning models in their basic assumption (what we consider as important or not and the questions we are asking), in their modelling (incorporating ...

  3. Early rehabilitation after stroke

    OpenAIRE

    Bernhardt, Julie; Godeckeb, Erin; Johnson, Liam; Langhorne, Peter

    2017-01-01

    Purpose of review: \\ud Early rehabilitation is recommended in many guidelines, with limited evidence to guide practice. Brain\\ud neurobiology suggests that early training, at the right dose, will aid recovery. In this review, we highlight\\ud recent trials of early mobilization, aphasia, dysphagia and upper limb treatment in which intervention is\\ud commenced within 7 days of stroke and discuss future research directions.\\ud Recent findings: \\ud Trials in this early time window are few. Althou...

  4. Early life of inshore fishes in Greenland

    DEFF Research Database (Denmark)

    Swalethorp, Rasmus

    reported from numerous fjords in Norway, Canada and Greenland, very little is known about their early life history and the physical-biological mechanisms impacting their survival in such inshore areas. To better understand the processes of importance to the early life success of fish, I carried out......During their early life stages, the fishes face a range of challenges. To sustain the development of the pelagic eggs and larvae spawning needs to occur where the offspring is retained in optimal environmental conditions. The larvae rely on a spatial and temporal match to their prey in order...... to ensure fast growthand avoid starvation. Inshore areas may provide such favorable conditions, as these are sheltered from offshore currents and act as physical barriers that restrict dispersal and drift of eggs and larvae. Even though inshore spawning grounds of e.g. Atlantic cod (Gadus morhua) has been...

  5. National Energy Act statutes and solar energy

    Energy Technology Data Exchange (ETDEWEB)

    Howard, J.

    1980-02-01

    The National Energy Act of 1978 contains many provisions that will significantly affect solar technology commercialization and solar energy users. Four of the five statutes that comprise the National Energy Act deserve close attention. The National Energy Conservation Policy Act will promote residential solar installations. The Energy Tax Act will accelerate both residential and commercial solar system applications. The Public Utilities Regulatory Policies Act promotes efficient use of utility resources as well as decentralized power production. And, the Power Plan and Industrial Fuel Use Act places severe restrictions on future burning of petroleum and natural gas, which should lead some operators to build or convert to solar energy systems. Each of the preceding acts are considered in separate sections of this report. Federal regulations issued pursuant to the various provisions are also identified and discussed, and some of the problems with the provisions and regulations are noted.

  6. 76 FR 67763 - Privacy Act of 1974; Privacy Act System of Records

    Science.gov (United States)

    2011-11-02

    ... SPACE ADMINISTRATION Privacy Act of 1974; Privacy Act System of Records AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of proposed revisions to an existing Privacy Act system of records. SUMMARY: Pursuant to the provisions of the Privacy Act of 1974 (5 U.S.C. 552a), the National...

  7. 76 FR 64112 - Privacy Act of 1974; Privacy Act System of Records Appendices

    Science.gov (United States)

    2011-10-17

    ... SPACE ADMINISTRATION Privacy Act of 1974; Privacy Act System of Records Appendices AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Revisions of NASA Appendices to Privacy Act System of... publishes with the Agency's systems of records under the Privacy Act of 1974. This notice publishes those...

  8. 76 FR 64115 - Privacy Act of 1974; Privacy Act System of Records

    Science.gov (United States)

    2011-10-17

    ... SPACE ADMINISTRATION Privacy Act of 1974; Privacy Act System of Records AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of the retirement of one Privacy Act system of records notice. SUMMARY: In accordance with the Privacy Act of 1974, NASA is giving notice that it proposes to...

  9. 76 FR 64114 - Privacy Act of 1974; Privacy Act System of Records

    Science.gov (United States)

    2011-10-17

    ... SPACE ADMINISTRATION Privacy Act of 1974; Privacy Act System of Records AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of proposed revisions to an existing Privacy Act system of records. SUMMARY: Pursuant to the provisions of the Privacy Act of 1974 (5 U.S.C. 552a), the National...

  10. 75 FR 81205 - Privacy Act: Revision of Privacy Act Systems of Records

    Science.gov (United States)

    2010-12-27

    ... Office of the Secretary Privacy Act: Revision of Privacy Act Systems of Records AGENCY: Office of the Secretary, USDA. ACTION: Notice to Revise Privacy Act Systems of Records. SUMMARY: Notice is hereby given that the United States Department of Agriculture (USDA) proposes to revise two Privacy Act Systems of...

  11. 78 FR 77719 - Privacy Act of 1974; Privacy Act System of Records

    Science.gov (United States)

    2013-12-24

    ... SPACE ADMINISTRATION Privacy Act of 1974; Privacy Act System of Records AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of Privacy Act system of records. SUMMARY: Pursuant to the provisions of the Privacy Act of 1974 (5 U.S.C. 552a), the National Aeronautics and Space Administration is...

  12. ACT Reporting Category Interpretation Guide: Version 1.0. ACT Working Paper 2016 (05)

    Science.gov (United States)

    Powers, Sonya; Li, Dongmei; Suh, Hongwook; Harris, Deborah J.

    2016-01-01

    ACT reporting categories and ACT Readiness Ranges are new features added to the ACT score reports starting in fall 2016. For each reporting category, the number correct score, the maximum points possible, the percent correct, and the ACT Readiness Range, along with an indicator of whether the reporting category score falls within the Readiness…

  13. 12 CFR 741.214 - Report of crime or catastrophic act and Bank Secrecy Act compliance.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Report of crime or catastrophic act and Bank Secrecy Act compliance. 741.214 Section 741.214 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION... Unions § 741.214 Report of crime or catastrophic act and Bank Secrecy Act compliance. Any credit union...

  14. 77 FR 34179 - Freedom of Information Act and Privacy Act Procedures

    Science.gov (United States)

    2012-06-11

    ... RECONSTRUCTION 5 CFR Chapter LXXXIII 5 Part 9301 RIN 3460-AA00 Freedom of Information Act and Privacy Act... Reconstruction under the Freedom of Information Act (FOIA) and the Privacy Act of 1974. These procedures will... 9301 Administrative practice and procedure, Freedom of information, Privacy. Accordingly, the interim...

  15. 32 CFR 2400.22 - Freedom of Information Act and Privacy Act requests.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Freedom of Information Act and Privacy Act... INFORMATION SECURITY PROGRAM Declassification and Downgrading § 2400.22 Freedom of Information Act and Privacy... that are submitted under the provisions of the Freedom of Information Act, as amended, or the Privacy...

  16. Personal Information as Communicative Acts

    DEFF Research Database (Denmark)

    Mai, Jens-Erik

    2016-01-01

    The paper extends previous accounts of informational privacy as a contextual notion. Where previous accounts have focused on interpretations of the privacy context itself as being contextual and open for negotiation and interpretation, this paper extends those analyses and shows that personal...... information itself is in fact best understood as contextual and situational—and as such open for interpretation. The paper reviews the notion of information as it has been applied in informational privacy and philosophy of information, and suggests that personal information ought to be regarded...... as communicative acts. The paper suggests a reconceptualization of informational privacy from having its focus on controlling, limiting, and restricting access to material carriers of information to a focus on a regulation of the use, analysis, and interpretation of personal information....

  17. The European Model Company Act

    DEFF Research Database (Denmark)

    Cleff, Evelyne Beatrix

    2011-01-01

    European Company Law regulation is currently undergoing a reform. These reforms raise a number of regulatory questions, such as what should be the aims of companies' legislation, and how these aims should best be met by regulation. Many of the reforms and discussions (both on EU and national level......) on the organisation of company laws reflect an interesting paradigm shift. Whereas, previously company law was primarily focused on preventing abuse, there is now a trend towards legislation that promote commerce and satisfy the needs of business. This means that the goal of economic efficiency is having...... an increasing influence on the framing of company legislation, such as the choice between mandatory or default rules. This article introduces the project 'European Company Law and the choice of Regulatory Method' which is carried out in collaboration with the 'European Model Company Act Group'. The project aims...

  18. Acting Antarctica: science on stage

    Science.gov (United States)

    Ciceri, Piera; Tizzoni, Paola; Pierro, Luigia

    2016-04-01

    Key-words: Polar science, Earth science, Theatre, Hands on activities The legendary Antarctic Expedition of sir E. Shackleton and his crew of 27 aboard the Endurance (1914/16) trapped in the Antarctic ice has become the starting point to learn about Polar Science and Climate Change. While the students were involved into this incredible adventure by the astonishing images of the Australian photographer Frank Hurley (who joined the crew), they discovered the world in which this story happened. Students were then involved in hands-on activities and role plays and have become the writers of the play "Uomini a scienza ai confini del mondo". They act the story of Shackelton's expedition and they tell at the same time to the audience about ice pack, ice cores and their role in understanding the past of the climate, physical and geographical characteristic of polar regions, thermal phenomena related to adaptations of polar animals, solar radiation at different latitude, day/night duration. The theater was the place to "stage" some scientific experiments and to explain the current research carried out in polar regions and their importance in climate change studies and to stress some similarities between Antarctica and space. The project was carried out from teachers of science, letters and geography and was born in collaboration with the "Piccolo Teatro di Milano" and the association "Science Under 18" with the support of a professional actor and director and was played for other schools at "EXPO 2015" in Milano (Italy). In our opinion drama activities improve reading comprehension, and both verbal and non-verbal communication skills. To be able to write and to act, students need a deep understanding of contents. Arts, including theatre, are a good key to involve emotionally students. To have an audience different from their own teachers and classmates offers a real task and the opportunity to play and let grow real skills.

  19. [Effects of treatment duration on the interpretation of ROM data in ACT patients].

    Science.gov (United States)

    Mulder, C L; Kortrijk, H E

    2012-01-01

    Patients with severe mental illness (SMI) generally receive long-term treatment. Interrupting treatment or leaving treatment early can lead to problems with the interpretation of routine outcome monitoring (ROM) data. To describe the link between early drop-out and treatment duration on the one hand, and patient characteristics and scores on a ROM outcome measure, namely the Camberwell Assessment of Need Short Appraisal Schedule (CANSAS), on the other hand. Annual CANSAS assessments of patients in assertive community treatment (ACT). 2946 CANSAS assessments were performed on 1041 patients who had been treated by an ACT team for an average of 1.4 years since their first ROM assessment. Patients who remained under treatment by an ACT team were more frequently male, born outside the Netherlands and had a psychotic or addiction disorder more frequently than patients who had left the ACT team treatment early. Patients who remained in ACT had, both at the start of treatment and at their last assessment, more unfulfilled needs than patients who had been treated for a shorter period. For the correct interpretation of ROM data for patients with SMI, one needs to have information about patient characteristics and the treatment duration.

  20. National Security/Emergency Preparedness and Disaster Recovery Communications Via ACTS

    Science.gov (United States)

    Pasqualino, Christopher R.; Abbe, Brian S.; Dixon, Frank

    1996-01-01

    During the period from early 1993 through 1994, the U.S. National Communication System, a government agency, sponsored the development and execution of several fixed and mobile experiments using the Advanced Communications Technology Satellite (ACTS)...The results of these experiments are described in this paper.

  1. How to Ask for a Favor: An Exploration of Speech Act Pragmatics in Heritage Russian

    Science.gov (United States)

    Dubinina, Irina Yevgenievna

    2012-01-01

    Heritage language (HL) is a linguistic system that arises in the context of early childhood bilingualism, both sequential and simultaneous, when one of the languages is not fully acquired. The performance of speech acts in HLs is yet to be understood, and this dissertation is a first step in this direction. The study investigates the pragmatic…

  2. Now Those Who Were Scattered Went about Preaching the Word (Acts 8:4: The Migrant Church and Its Mission According to the Book of Acts

    Directory of Open Access Journals (Sweden)

    Stenschke, Christoph

    2016-03-01

    Full Text Available After a brief survey of migration in the Bible, this article examines migration be it voluntary or enforced in the Book of Acts. Acts describes in Stephen's speech in surprising detail experiences of migration in Israel's past and its theological implications. Acts also describes that many early Christian missionaries served in places that were not their places of origin, voluntarily or by force: the disciples ended up in Jerusalem and eventually at the ends of the earth rather than returning to Galilee. Others had come to Jerusalem from elsewhere even before encountering the Gospel and ministered throughout the Eastern Mediterranean world as they became involved in mission. Early Christian mission is closely related to migration and dislocation, voluntary or by force, led by the Spirit and for the sake of the Gospel. Repeatedly other missionaries had to flee in order to avoid persecution. Despite the tragedy and suffering involved, there were also great opportunities which were readily seized: the Gospel moved forward. Much of early Christian mission was accomplished by refugees. A final section reflects on the significance of this portrayal of early Christian mission for the church and its mission in the 21st century.

  3. Act of 15 July 1987.

    Science.gov (United States)

    1987-01-01

    The text of this Act on artificial insemination is as follows: "1. If, under the supervision of a licensed physician and with the consent of her husband, a wife is inseminated artificially with semen donated by a man not her husband, the husband is treated in law as if he were the natural father of a child thereby conceived. The husband's consent must be in writing and signed by him and his wife. The physician shall certify their signatures and the date of the insemination, and file the husband's consent with the bureau, where it shall be kept confidential and in a sealed file. The physician's failure to comply with this section shall not affect the father and child relationship. All papers and records pertaining to the insemination, whether part of the permanent record of a court or of a file held by the supervising physician or elsewhere, are subject to inspection only upon an order of the court for good cause shown. 2. The donor of semen provided to a licensed physician for use in artificial insemination of a married woman other than the donor's wife is treated in law as if he were not the natural father of a child thereby conceived." full text

  4. ACT++: Building a Concurrent C++ with Actors

    OpenAIRE

    Kafura, Dennis G.; Lee, Keung Hae

    1989-01-01

    ACT++ (Actors in C++) is a concurrent object-oriented language being designed for distributed real-time applications. The language is a hybrid of the actor kernel language and the object-oriented language C++. The concurrency abstraction of ACT++ is derived from the actor model as defined by Agha. This paper discusses our experience in building a concurrent extension of C++ with the concurrency abstraction of the actor model. The current design of ACT++ and its implementation are described. S...

  5. 75 FR 65229 - Privacy Act; Implementation

    Science.gov (United States)

    2010-10-22

    ... FURTHER INFORMATION CONTACT: Dale Underwood, Privacy Act officer, Department of the Treasury, 1500....underwood@do.treas.gov . SUPPLEMENTARY INFORMATION: The Department of the Treasury is publishing separately...

  6. BBG 2009 Freedom of Information Act Repot

    Data.gov (United States)

    Broadcasting Board of Governors — The Broadcasting Board of Governors' annual Freedom of Information Act (FOIA) report includes detailed statistics on the number and disposition of FOIA requests,...

  7. BBG 2008 Freedom of Information Act Report

    Data.gov (United States)

    Broadcasting Board of Governors — The Broadcasting Board of Governors' annual Freedom of Information Act (FOIA) report includes detailed statistics on the number and disposition of FOIA requests,...

  8. Resource Conservation and Recovery Act Information (RCRAInfo)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Resource Conservation and Recovery Act Information (RCRAInfo) system contains information reported to the state environmental programs on activities and cleanup...

  9. Colorado's Model for Preparing Paraprofessionals for Rural Early Intervention Programs

    Science.gov (United States)

    Chopra, Ritu; Banerjee, Rashida; DiPalma, Geraldine; Merrill, Laura; Ferguson, Ardith

    2013-01-01

    Under the supervision of a licensed early intervention provider, paraprofessionals play an indispensable role in implementation of home and community-based services to infants and toddlers with developmental delays or disabilities and their families in Colorado. The Individuals with Disabilities Education Act of 2004 requires that…

  10. Worms, Shadows and Whirlpools: Science in the Early Childhood Classroom.

    Science.gov (United States)

    Worth, Karen; Grollman, Sharon

    Young children develop science knowledge as they observe and act on the world, asking questions, making predictions, testing those predictions, and reflecting on their experiences. This book offers guidance in integrating inquiry-based science into the early childhood curriculum, focusing on content and providing examples of the work of children…

  11. Early Childhood Dental Caries. Building Community Systems for Young Children.

    Science.gov (United States)

    Platt, Laurence J.; Cabezas, Maritza C.

    As part of a series of reports designed to support the implementation of Proposition 10: The California Children and Families Act and to provide comprehensive and authoritative information on critical issues concerning young children and families in California, this report describes the scope and severity of early childhood caries (ECC), a…

  12. Telerehabilitation: An Adjunct Service Delivery Model for Early Intervention Services

    Directory of Open Access Journals (Sweden)

    Jana Cason

    2011-05-01

    Full Text Available Early Intervention (EI services for children birth through two years of age are mandated by Part C of the Individuals with Disabilities Education Act (IDEA; however, personnel shortages, particularly in rural areas, limit access for children who qualify. Telerehabilitation has the potential to build capacity among caregivers and local providers as well as promote family-centered services through remote consultation.  This article provides an overview of research related to telerehabilitation and early intervention services; discusses the feasibility of telerehabilitation within traditional EI service delivery models; examines telecommunications technology associated with telerehabilitation; and provides hypothetical case examples designed to illustrate potential applications of telerehabilitation in early intervention.

  13. Telerehabilitation: an adjunct service delivery model for early intervention services.

    Science.gov (United States)

    Cason, Jana

    2011-01-01

    Early Intervention (EI) services for children birth through two years of age are mandated by Part C of the Individuals with Disabilities Education Act (IDEA); however, personnel shortages, particularly in rural areas, limit access for children who qualify. Telerehabilitation has the potential to build capacity among caregivers and local providers as well as promote family-centered services through remote consultation. This article provides an overview of research related to telerehabilitation and early intervention services; discusses the feasibility of telerehabilitation within traditional EI service delivery models; examines telecommunications technology associated with telerehabilitation; and provides hypothetical case examples designed to illustrate potential applications of telerehabilitation in early intervention.

  14. Early juvenile idiopathic arthritis.

    Science.gov (United States)

    Marzan, Katherine Anne B; Shaham, Bracha

    2012-05-01

    Early juvenile idiopathic arthritis (JIA) is important to recognize as timely diagnosis and treatment improves prognosis. It is a misconception that complications of JIA arise only from long-standing disease and that children will outgrow it. Early aggressive treatment is the paradigm as early disease activity has long-term consequences. There are predictors of persistent disease and joint erosions that may identify patients at higher risk. Control of disease activity within the first 6 months of onset confers improved clinical course and outcomes. The treatment perspective is thus one of early aggressive treatment for induction of disease control and ultimately remission. Copyright © 2012 Elsevier Inc. All rights reserved.

  15. Recovery act : states' use of highway infrastructure funds and compliance with the act's requirements.

    Science.gov (United States)

    2009-01-01

    The American Recovery and Reinvestment Act of 2009 (Recovery Act) included more than $48 billion for the Department of Transportations (DOT) investment in transportation infrastructure, including highways, rail, and transit. This testimonybased...

  16. Definition of Terrorist Act under Eth Law

    African Journals Online (AJOL)

    Wondwossen_D_K

    Abstract. While regional and international human rights institutions claim that the definition of a terrorist act under the Anti-terrorism Proclamation No. 652/2009 is overly broad as a result of which citizens not involved in a genuinely terrorist act are prosecuted and jailed, the Ethiopian government defends the law pointing ...

  17. 7 CFR 1209.1 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1209.1 Section 1209.1 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND... the Food, Agriculture, Conservation, and Trade Act of 1990, Pub. L. 101-624, 7 U.S.C. 6101-6112, and...

  18. 7 CFR 1220.600 - Act.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1220.600 Section 1220.600 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS..., Agriculture, Conservation, and Trade Act of 1990 (Pub. L. 101-624), and any amendments thereto. ...

  19. Second Language Learners and Speech Act Comprehension

    Science.gov (United States)

    Holtgraves, Thomas

    2007-01-01

    Recognizing the specific speech act ( Searle, 1969) that a speaker performs with an utterance is a fundamental feature of pragmatic competence. Past research has demonstrated that native speakers of English automatically recognize speech acts when they comprehend utterances (Holtgraves & Ashley, 2001). The present research examined whether this…

  20. 75 FR 12584 - Sunshine Act; Public Hearing

    Science.gov (United States)

    2010-03-16

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Sunshine Act; Public Hearing March 17, 2010. OPIC's Sunshine Act notice of its Public Hearing in... record; therefore, OPIC's public hearing scheduled for 3 p.m., March 17, 2010 in conjunction with OPIC's...

  1. ACT UP as a Structure of Feeling

    Science.gov (United States)

    Gingrich-Philbrook, Craig

    2012-01-01

    Revisiting AIDS Coalition to Unleash Power (ACT UP) restarts the "panic of loss" characterizing the author's youth. The author argues that the 25th anniversary of ACT UP marks the failure to consider Raymond Williams's "structure of feeling". Williams counterposes this structure against falsely viewing the past as formalized into something…

  2. The Dutch Euthanasia Act and related issues

    NARCIS (Netherlands)

    Legemaate, Johan

    2004-01-01

    In 2002 the Dutch Euthanasia Act came into force. This Act is the result of a lengthy developmental process. It codifies the requirements that have evolved in case law and medical ethics since 1973. Empirical data indicate that the Dutch euthanasia practice is stabilising. Euthanasia and assisted

  3. Two cheers for the Monetary Control Act

    OpenAIRE

    Katy Jacob; Daniel A. Littman; Richard D. Porter; Wade Rousse

    2010-01-01

    This article explains how the Monetary Control Act (MCA) of 1980 paved the way for the transition away from paper to electronic check clearing and processing, ultimately leading to the successful implementation of the Check Clearing for the 21st Century Act (Check 21) in 2003.

  4. Acting green elicits a literal warm glow

    NARCIS (Netherlands)

    Taufik, Danny; Bolderdijk, Jan Willem; Steg, Linda

    Environmental policies are often based on the assumption that people only act environmentally friendly if some extrinsic reward is implicated, usually money(1,2). We argue that people might also be motivated by intrinsic rewards: doing the right thing (such as acting environmentally friendly)

  5. 75 FR 62889 - Sunshine Act Meetings

    Science.gov (United States)

    2010-10-13

    ... From the Federal Register Online via the Government Publishing Office LEGAL SERVICES CORPORATION.... Report on developments in LSC research agenda. 5. Consider and act on nature, process, and timing of IG... Closed Session meeting of September 21, 2010. 25. IG briefing of the Board. 26. Consider and act on...

  6. 77 FR 2092 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2012-01-13

    ... From the Federal Register Online via the Government Publishing Office LEGAL SERVICES CORPORATION Sunshine Act Meeting Notice DATE AND TIME: The Legal Services Corporation's Board of Directors and its six... and other officers of the Corporation. 6. IG Evaluation discussion for 2011. 7. Consider and act on...

  7. Equationally Compact Acts : Coproducts / Peeter Normak

    Index Scriptorium Estoniae

    Normak, Peeter

    1998-01-01

    In this article equational compactness of acts and its generalizations are discussed. As equational compactness does not carry over to coproducts a slight generalization of c-equational campactness is introduced. It is proved that a coproduct of acts is c-equationally compact if and only if all components are c-equationally campact

  8. 77 FR 42175 - Securities Act Industry Guides

    Science.gov (United States)

    2012-07-18

    ... Securities Act Industry Guides AGENCY: Securities and Exchange Commission. ACTION: Technical amendments... Disclosure by Bank Holding Companies (``Industry Guide 3''), and Guide 7, Description of Property by Issuers Engaged or to be Engaged in Significant Mining Operations (``Industry Guide 7''), of the Securities Act of...

  9. 75 FR 66811 - Sunshine Act Meeting

    Science.gov (United States)

    2010-10-29

    ..., and deception in connection with security-based swaps. 3. The Commission will consider whether to... the Dodd-Frank Wall Street Reform and Consumer Protection Act, provides that the Commission shall pay... COMMISSION Sunshine Act Meeting Notice is hereby given, pursuant to the provisions of the Government in the...

  10. a speech act analysis of John 9

    African Journals Online (AJOL)

    The purpose of my previous article was to continue to show the validity of a speech act approach and to develop it further in the reading of biblical texts. As a successive study, this article aims to present yet another speech act analysis, which will put more focus on a demonstration that this approach is able to deal even with ...

  11. Acts of Reading: Teachers, Text and Childhood

    Science.gov (United States)

    Styles, Morag, Ed.; Arizpe, Evelyn, Ed.

    2009-01-01

    "Acts of Reading" is an enchanting and scholarly review of the history of reading and texts for children, from the 18th century to the digital age and beyond. They are examined through the eyes of their various audiences: the children, writers, teachers and parents, so as to explore the act of reading itself, whether oral, silent or performative,…

  12. Speech Act Theory and Foreign Language Learning.

    Science.gov (United States)

    Coombs, Virginia M.

    This paper discusses how an understanding of speech acts contributes to the communicative competence in foreign language learning. Reviewing John Searle's five categories of speech acts (1976), the directive is discussed in terms of its manifestations in various foreign languages. Examples of directives in English, German, French, and Spanish are…

  13. A Speech Act Theory of Metadiscourse.

    Science.gov (United States)

    Beauvais, Paul

    1989-01-01

    Provides representative examples of the problems that diminish the utility of current metadiscourse theories, and proposes an alternative theory that locates metadiscourse within the larger context of speech act theory. Defines metadiscourse as indicators of expositive illocutionary acts, and provides a taxonomy of metadiscursive functions and…

  14. Let's Pass a Student Publications Act!

    Science.gov (United States)

    Plopper, Bruce L.

    1995-01-01

    Describes the evolutionary process of the State of Arkansas' Student Publications Act which goes into effect 1 January, 1996. Explains that the draft form of the Act emphasized the importance of recognizing students' right of free expression and stressed the importance of journalistic responsibility and high standards for academic advisors.…

  15. Jamaica on Early Maps.

    Science.gov (United States)

    Richason, Benjamin F., Jr.

    1983-01-01

    Columbus sighted Jamaica during his second voyage and was marooned there for more than a year during his fourth. The succession of early maps of Jamaica betrays its slow development and its unimportance to early colonizers. Modern tourism is the elusive "gold" which the Spanish fortune hunters did not find. (CS)

  16. Early detection of psychosis

    DEFF Research Database (Denmark)

    Larsen, T. K.; Melle, I.; Auestad, B.

    2011-01-01

    Background During the last decades we have seen a new focus on early treatment of psychosis. Several reviews have shown that duration of untreated psychosis (DUP) is correlated to better outcome. However, it is still unknown whether early treatment will lead to a better long-term outcome. This st...

  17. Early College High Schools

    Science.gov (United States)

    Dessoff, Alan

    2011-01-01

    For at-risk students who stand little chance of going to college, or even finishing high school, a growing number of districts have found a solution: Give them an early start in college while they still are in high school. The early college high school (ECHS) movement that began with funding from the Bill and Melinda Gates Foundation 10 years ago…

  18. Waterford Early Reading Program.

    Science.gov (United States)

    Education Commission of the States, Denver, CO.

    This paper provides an overview of the Waterford Early Reading Program (WERP), which is designed to shift teaching and learning away from remediation and failure to prevention, early achievement, and sustained growth for every student. WERP includes three levels of instruction: emergent, beginning, and fluent readers. It targets pre-K through…

  19. Rethinking Early Education

    Science.gov (United States)

    Celeste, Eric

    2017-01-01

    The National Association for the Education of Young Children (NAEYC) says in its current policy paper that, for high-quality early education to exist outside of tiny islands across the country, the following must be addressed: (1) teacher preparation; (2) ongoing professional learning; and (3) disparity in early education teacher pay. To achieve…

  20. Pay Equity Act, 19 May 1989.

    Science.gov (United States)

    1989-01-01

    This document contains major provisions of the 1989 Pay Equity Act of the Province of New Brunswick, Canada. This Act implements pay equity to public service employees. The Act sets out the conditions which may prevail and cause differences in pay between a female-dominated class and a male-dominated class. These include a formal seniority system which does not discriminate on the basis of gender, a temporary employee training assignment, a merit pay plan that does not discriminate, a gender-neutral reevaluation process to down-grade a position, or a temporary increase in pay due to a skills shortage. The Act provides that comparisons be made between female-dominated classes and male-dominated classes in terms of pay on an hourly basis and the value of the work performed. No employee is to have pay reduced in order to implement this Act.

  1. Machine learning techniques in dialogue act recognition

    Directory of Open Access Journals (Sweden)

    Mark Fišel

    2007-05-01

    Full Text Available This report addresses dialogue acts, their existing applications and techniques of automatically recognizing them, in Estonia as well as elsewhere. Three main applications are described: in dialogue systems to determine the intention of the speaker, in dialogue systems with machine translation to resolve ambiguities in the possible translation variants and in speech recognition to reduce word recognition error rate. Several recognition techniques are described on the surface level: how they work and how they are trained. A summary of the corresponding representation methods is provided for each technique. The paper also includes examples of applying the techniques to dialogue act recognition.The author comes to the conclusion that using the current evaluation metric it is impossible to compare dialogue act recognition techniques when these are applied to different dialogue act tag sets. Dialogue acts remain an open research area, with space and need for developing new recognition techniques and methods of evaluation.

  2. Exploring primary care activities in ACT teams.

    Science.gov (United States)

    Vanderlip, Erik R; Williams, Nancy A; Fiedorowicz, Jess G; Katon, Wayne

    2014-05-01

    People with serious mental illness often receive inadequate primary and preventive care services. Federal healthcare reform endorses team-based care that provides high quality primary and preventive care to at risk populations. Assertive community treatment (ACT) teams offer a proven, standardized treatment approach effective in improving mental health outcomes for the seriously mentally ill. Much is known about the effectiveness of ACT teams in improving mental health outcomes, but the degree to which medical care needs are addressed is not established. The purpose of this study was to explore the extent to which ACT teams address the physical health of the population they serve. ACT team leaders were invited to complete an anonymous, web-based survey to explore attitudes and activities involving the primary care needs of their clients. Information was collected regarding the use of health screening tools, physical health assessments, provision of medical care and collaboration with primary care systems. Data was analyzed from 127 team leaders across the country, of which 55 completed the entire survey. Nearly every ACT team leader believed ACT teams have a role in identifying and managing the medical co-morbidities of their clientele. ACT teams report participation in many primary care activities. ACT teams are providing a substantial amount of primary and preventive services to their population. The survey suggests standardization of physical health identification, management or referral processes within ACT teams may result in improved quality of medical care. ACT teams are in a unique position to improve physical health care by virtue of having medically trained staff and frequent, close contact with their clients.

  3. 45 CFR 2543.86 - Clean Air Act and the Federal Water Pollution Control Act.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Clean Air Act and the Federal Water Pollution... Water Pollution Control Act. Contracts and subgrants of amounts in excess of $100,000 shall contain a... regulations issued pursuant to the Clean Air Act (42 U.S.C. 7401 et seq.) and the Federal Water Pollution...

  4. 78 FR 19744 - Privacy Act of 1974; Privacy Act System of Records

    Science.gov (United States)

    2013-04-02

    ... workstations within the NASA Intranet. RETENTION AND DISPOSAL: Records are retained in a computer database and... SPACE ADMINISTRATION Privacy Act of 1974; Privacy Act System of Records AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of a Privacy Act system of records. SUMMARY: Each Federal...

  5. 78 FR 19745 - Privacy Act of 1974; Privacy Act System of Records

    Science.gov (United States)

    2013-04-02

    ... approved authentication methods can access the system. RETENTION AND DISPOSAL: Records are maintained and... SPACE ADMINISTRATION Privacy Act of 1974; Privacy Act System of Records AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of Privacy Act system of records. SUMMARY: Each Federal...

  6. 75 FR 36535 - Freedom of Information Act, Privacy Act of 1974; Implementation

    Science.gov (United States)

    2010-06-28

    ... Office of the Secretary 31 CFR Part 1 Freedom of Information Act, Privacy Act of 1974; Implementation... of the Treasury's regulations on the disclosure of records under the Freedom of Information Act (FOIA... CFR Part 1 Freedom of Information; Privacy. 0 Accordingly, part 1 of title 31 of the Code of Federal...

  7. 78 FR 28532 - Freedom of Information, Privacy Act, and Government in the Sunshine Act Procedures

    Science.gov (United States)

    2013-05-15

    ...; ] PRIVACY AND CIVIL LIBERTIES OVERSIGHT BOARD 6 CFR Chapter X RIN 0311-AA01 Freedom of Information, Privacy... proposing regulations to implement the Freedom of Information Act, the Privacy Act of 1974, and the... implement the Board's procedures required under the Freedom of Information Act (FOIA), 5 U.S.C. 552, as...

  8. 75 FR 743 - Freedom of Information Act, Privacy Act of 1974; Implementation

    Science.gov (United States)

    2010-01-06

    ... Office of the Secretary 31 CFR Part 1 Freedom of Information Act, Privacy Act of 1974; Implementation... the Treasury's regulations on the disclosure of records under the Freedom of Information Act (FOIA... Subjects in 31 CFR Part 1 Freedom of Information; Privacy. 0 Part 1 of Title 31 of the Code of Federal...

  9. 75 FR 24549 - Merchant Marine Act and Magnuson-Stevens Fishery Conservation and Management Act (Magnuson...

    Science.gov (United States)

    2010-05-05

    ... Magnuson-Stevens Fishery Conservation and Management Act (Magnuson-Stevens Act) Provisions; Fishing Vessel... rule; request for comments. SUMMARY: The Fisheries Finance Program (FFP or the Program) provides long... Magnuson-Stevens Fishery Conservation and Management Reauthorization Act, (MSRA), 46 U.S.C. 53706(a)(7...

  10. 75 FR 78619 - Shipping Act, Merchant Marine, and Magnuson-Stevens Fishery Conservation and Management Act...

    Science.gov (United States)

    2010-12-16

    ..., and Magnuson-Stevens Fishery Conservation and Management Act (Magnuson-Stevens Act) Provisions... well as the Magnuson-Stevens Act. These regulations revise the operating rules of the Fisheries Finance... Finance Program, 301-713-2390. SUPPLEMENTARY INFORMATION: Electronic Access This final rule is also...

  11. The early emergence of sociomoral evaluation: infants prefer prosocial others.

    Science.gov (United States)

    Van de Vondervoort, Julia W; Hamlin, Jane Kiley

    2017-08-12

    Humans readily evaluate third-parties' prosocial and antisocial acts. Recent evidence reveals that this tendency emerges early in development-even preverbal infants selectively approach prosocial others and avoid antisocial ones. Rather than reflecting attraction toward or away from low-level characteristics of the displays or simple behavioral rules, infants are sensitive to characteristics of both the agents and recipients of prosocial and antisocial acts. Specifically, infants' preferences require that the recipients of positive and negative acts be social agents with clear unfulfilled goals, who have not previously harmed others. In addition, prosocial and antisocial agents must act intentionally, in the service of positive and negative goals. It is an open question whether these prosocial preferences reflect self-interested and/or moral concerns. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. 76 FR 15857 - Radio Broadcasting Services; Early and Lake Brownwood, TX

    Science.gov (United States)

    2011-03-22

    ... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Early and Lake Brownwood, TX AGENCY: Federal... counterproposal filed by Munbilla Broadcasting Properties, Ltd., requesting the allotment of Channel 294A at Early... the Congressional Review Act, see U.S.C. 801(a)(1)(A). List Of Subjects in 47 CFR Part 73 Radio, Radio...

  13. 76 FR 53563 - Applications for New Awards; Race to the Top-Early Learning Challenge

    Science.gov (United States)

    2011-08-26

    ... agenda that is focused on school readiness and ongoing academic success. They are central to this... literacy development, cognition and general knowledge (including early mathematics and early scientific... and Adult Care Food Program, and the Adult Education and Family Literacy Act (AEFLA) may be...

  14. Acting green elicits a literal warm glow

    Science.gov (United States)

    Taufik, Danny; Bolderdijk, Jan Willem; Steg, Linda

    2015-01-01

    Environmental policies are often based on the assumption that people only act environmentally friendly if some extrinsic reward is implicated, usually money. We argue that people might also be motivated by intrinsic rewards: doing the right thing (such as acting environmentally friendly) elicits psychological rewards in the form of positive feelings, a phenomenon known as warm glow. Given the fact that people's psychological state may affect their thermal state, we expected that this warm glow could express itself quite literally: people who act environmentally friendly may perceive the temperature to be higher. In two studies, we found that people who learned they acted environmentally friendly perceived a higher temperature than people who learned they acted environmentally unfriendly. The underlying psychological mechanism pertains to the self-concept: learning you acted environmentally friendly signals to yourself that you are a good person. Together, our studies show that acting environmentally friendly can be psychologically rewarding, suggesting that appealing to intrinsic rewards can be an alternative way to encourage pro-environmental actions.

  15. Early Option Exercise

    DEFF Research Database (Denmark)

    Jensen, Mads Vestergaard; Heje Pedersen, Lasse

    2016-01-01

    A classic result by Merton (1973) is that, except just before expiration or dividend payments, one should never exercise a call option and never convert a convertible bond. We show theoretically that this result is overturned when investors face frictions. Early option exercise can be optimal when...... it reduces short-sale costs, transaction costs, or funding costs. We provide consistent empirical evidence, documenting billions of dollars of early exercise for options and convertible bonds using unique data on actual exercise decisions and frictions. Our model can explain as much as 98% of early exercises...

  16. 75 FR 8013 - Serve America Act Amendments to the National and Community Service Act of 1990

    Science.gov (United States)

    2010-02-23

    ...On April 21, 2009, President Obama signed into law the Edward M. Kennedy Serve America Act (``The Serve America Act'' or ``SAA''). The Serve America Act reauthorizes and expands national service programs administered by the Corporation for National and Community Service (``the Corporation'') by amending the National and Community Service Act of 1990 (``NCSA'' or ``the Act'') and the Domestic Volunteer Service Act of 1973 (``DVSA''). The Corporation publishes this proposed rule to implement changes to the operation of the National Service Trust under the Serve America Act. This proposed rule provides flexibility for exceptions to the 80 percent cost reimbursement requirement for Senior Companion and Foster Grandparent programs based on hardship. In addition, this proposed rule reorders and renumbers certain parts of the existing regulations, adds new definitions, and makes several minor technical edits.

  17. The Genetic Privacy Act and commentary

    Energy Technology Data Exchange (ETDEWEB)

    Annas, G.J.; Glantz, L.H.; Roche, P.A.

    1995-02-28

    The Genetic Privacy Act is a proposal for federal legislation. The Act is based on the premise that genetic information is different from other types of personal information in ways that require special protection. Therefore, to effectively protect genetic privacy unauthorized collection and analysis of individually identifiable DNA must be prohibited. As a result, the premise of the Act is that no stranger should have or control identifiable DNA samples or genetic information about an individual unless that individual specifically authorizes the collection of DNA samples for the purpose of genetic analysis, authorized the creation of that private information, and has access to and control over the dissemination of that information.

  18. The Dutch Euthanasia Act and related issues.

    Science.gov (United States)

    Legemaate, Johan

    2004-02-01

    In 2002 the Dutch Euthanasia Act came into force. This Act is the result of a lengthy developmental process. It codifies the requirements that have evolved in case law and medical ethics since 1973. Empirical data indicate that the Dutch euthanasia practice is stabilising. Euthanasia and assisted suicide occur in 2.7% of all deaths. Now that the Act has been passed, the focus is on improving the quality of medical decision-making. From an international perspective, the Dutch legislation is exceptional. However, it appears that other countries and international organisations are considering euthanasia legislation as well. It remains to be seen how influential the Dutch model will prove to be.

  19. Early Life Stages

    Science.gov (United States)

    Childhood should be viewed as a sequence of lifestages, from birth through infancy and adolescence. When assessing early life risks, consideration is given to risks resulting from fetal exposure via the pregnant mother, as well as postnatal exposures.

  20. Early stage colon cancer

    National Research Council Canada - National Science Library

    Freeman, Hugh James

    2013-01-01

    .... After resection of malignant pedunculated colon polyps or early stage colon cancers, long-term repeated surveillance programs can also lead to detection and removal of asymptomatic high risk advanced...

  1. Tooth decay - early childhood

    Science.gov (United States)

    Bottle mouth; Bottle carries; Baby bottle tooth decay; Early childhood caries (ECC) ... inside of your baby's mouth healthy and prevents tooth decay. If you are bottle-feeding your baby: Give babies, ages newborn to ...

  2. Early warning scores.

    Science.gov (United States)

    2012-09-27

    A free app available from the Apple App Store is aimed at supporting health professionals in Wales to use the National Early Warning Score (NEWS). The tool helps staff identify patients who are developing serious illness.

  3. Early Head Start Evaluation

    Data.gov (United States)

    U.S. Department of Health & Human Services — Longitudinal information from an evaluation where children were randomly assigned to Early Head Start or community services as usual;direct assessments and...

  4. Overview of Early Intervention

    Science.gov (United States)

    ... eligible babies and toddlers learn the basic and brand-new skills that typically develop during the first ... Services in Natural Environments Transition to Preschool Public Awareness & the Referral System Early Intervention, Then and Now ...

  5. Guideline for Early Interventions

    National Research Council Canada - National Science Library

    Vries, de, Maaike

    2006-01-01

    .... During the last years, the demand for early interventions has been increasing. International literature has shown that the psychosocial effects of disaster and military deployment may last for years...

  6. Early-onset schizophrenia

    OpenAIRE

    Hojka Gregorič Kumperščak

    2013-01-01

    Early-onset schizophrenia is defined as schizophrenia with onset before the age of 18 years. While schizophrenia is a very rare disorder in childhood, it becomes increasingly common during adolescence and peaks in early adulthood. Even though childhood and adolescent schizophrenia lie on a continuum with adult schizophrenia and show roughly the same clinical picture, they both have some developmental specifics. They display greater symptom variability making the ...

  7. Embracing early literacy indicators

    DEFF Research Database (Denmark)

    Broström, Stig; Hansen, Ole Henrik; Jensen, Anders Skriver

    2010-01-01

    Abstract til paper om early literacy indikatorer. Det paper abstractet er knyttet til var en del af et inviteret, selvorganiseret symposium som afrapporterede EASE-projektet (www.ease-eu.com) på OMEP's 26. verdenskongres.......Abstract til paper om early literacy indikatorer. Det paper abstractet er knyttet til var en del af et inviteret, selvorganiseret symposium som afrapporterede EASE-projektet (www.ease-eu.com) på OMEP's 26. verdenskongres....

  8. Annual Freedom of Information Act (FOIA) Reports

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA makes annual reports of progress made on Freedom of Information Act (FOIA) requests. This database contains PDF and XML versions of reports from 1999 to the...

  9. Experiences from an ACT programme in Copenhagen

    DEFF Research Database (Denmark)

    Benjaminsen, Lars

    This working paper presents intermediary results of a study of an ACT-program (Assertive Community Treatment) in Copenhagen, Denmark. The ACT-program is aimed at rehousing homeless individuals and providing floating support in the citizens own home from a multidisciplinary support team. The target......, and social workers with administrative authority from the social office and the job center. In the international research literature ACT has been shown in randomized controlled trials to be a very effective method in bringing individuals out of homelessness and into a stable housing situation. This study...... is based on quantitative outcome measurement in an intervention group of about 60 homeless individuals who through the program has received both a housing solution and support from the ACT-team. The study is not a randomized controlled trial as there is no control group. Furthermore qualitative interviews...

  10. VT Act 174 Ground Mount Solar Potential

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) The only statewide solar potential layer available used in the Act 174 effort comes from the 2010 Renewable Energy Atlas of Vermont (REAVT) effort...

  11. ACTS FOR TODAY 'S MISSIONAL CHURCH

    African Journals Online (AJOL)

    2010-01-30

    Jan 30, 2010 ... 75 Elveram Street,. Lynnwood Glen, Pretoria. 0081, South Africa. Keywords: Acts; Bevansand Schroeder; contextualisation; discernment; globalisation; hospitality to strangers; inclusivity; missio Dei; missional church; missional listening; prophetic dialogue; resolving conflict. Dates: Received: 26 Aug. 2009.

  12. Magnuson-Stevens Fishery Conservation Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Magnuson-Stevens Fishery Conservation and Management Act (MSA) is the primary law governing marine fisheries management in U.S. federal waters. It has since been...

  13. 76 FR 44057 - Sunshine Act Meeting.

    Science.gov (United States)

    2011-07-22

    ... credit ratings with alternative criteria. These amendments are in light of Section 939A of the Dodd-Frank... the Investment Company Act of 1940 to require an institutional investment manager that is subject to...

  14. 78 FR 4462 - Sunshine Act; Meeting Notice

    Science.gov (United States)

    2013-01-22

    ..., please refrain from placing the call on hold if doing so will trigger recorded music or other sound. From... act on adjournment of meeting Closed Briefing 10. Communication by Corporate Auditor with those...

  15. 75 FR 969 - Sunshine Act Notice

    Science.gov (United States)

    2010-01-07

    ... of Briefing Report on Covert Wiretapping in the War on Terror Multi-Ethnic Placement Act Briefing... Issues Pennsylvania IV. Approval of December 16, 2009 Meeting Minutes V. Staff Director's Report VI...

  16. Comprehensive Environmental Response, Compensation and Liability Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), commonly known as Superfund, provides a federal "superfund" to clean up...

  17. 76 FR 63660 - Sunshine Act Meetings; Notice

    Science.gov (United States)

    2011-10-13

    ... recommendations. 4. Discussion of President, Officers, and IG evaluations for 2011. 5. Consider and act on other... comments published in the Federal Register at 76 FR 169 (August 31, 2011). 15. Public comment. 16. Consider...

  18. 76 FR 7551 - Sunshine Act Meeting

    Science.gov (United States)

    2011-02-10

    ... Military and Overseas Voter Empowerment Act (MOVE), and working with local media outlets to effectively..., receive updates on EAC activities, and consider other administrative matters. Finally, the Standards Board...

  19. Recovery Act. Tapoco project. Cheoah upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Tran, Paul [Alcoa Inc., Alcoa Center, PA (United States)

    2013-10-02

    Under Funding Opportunity Announcement Number: DE-FOA-0000120, Recovery Act: Hydroelectric Facility Modernization, Alcoa Power Generating Inc. (APGI), a fully owned subsidiary of Alcoa Inc., implemented major upgrades at its Cheoah hydroelectric facility near Robbinsville, North Carolina.

  20. 76 FR 78257 - Sunshine Act Notice

    Science.gov (United States)

    2011-12-16

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Sunshine Act Notice AGENCY: Federal Election Commission Federal Register CITATION OF PREVIOUS ANNOUNCEMENT...--Independent Expenditure Reporting by Persons other than Political Committees Draft Notice of Proposed...

  1. The Clean Air Act and the Economy

    Science.gov (United States)

    Since 1970, cleaner air and a growing economy have gone hand in hand. The Act has created market opportunities that have helped to inspire innovation in cleaner technologies for which the United States has become a global market leader.

  2. 76 FR 42709 - Sunshine Act Notice

    Science.gov (United States)

    2011-07-19

    .... Arrest and Conviction Records as a Barrier to Employment. Note: In accordance with the Sunshine Act, the... information on these meetings. The EEOC provides sign language interpretation and Communication Access...

  3. Freedom of Information Act (FOIA) Plan

    Data.gov (United States)

    Office of Personnel Management — Executive Order (E.O.) 13,392 mandates that each federal agency shall have a Freedom of Information Act (FOIA) working plan with established goals and time frames to...

  4. Federal Funding Accountability and Transparency Act

    Science.gov (United States)

    Public Law 109-282, the Federal Funding Accountability and Transparency Act of 2006 as amended (FFATA), requires disclosure of all entities and organizations receiving Federal funds through a single publicly accessible website.

  5. 77 FR 42513 - Sunshine Act Meetings Notice

    Science.gov (United States)

    2012-07-19

    .... Carol Bergman, Director, Government Relations and Public Affairs. 6. Consider and act on recommendation to the Board of Directors for FY 2014 Budget Request. Presentation by Carol Bergman, Director...

  6. Freedom of Information Act (FOIA) Tracking System

    Data.gov (United States)

    Office of Personnel Management — Tracking system which allows for the input of the Freedom of Information Act (FOIA) request date, compiles the due date, information pertaining to the request, name...

  7. Marine Debris Research, Prevention, and Reduction Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Marine Debris Research, Prevention, and Reduction Act legally establishes the National Oceanic and Atmospheric Administration's (NOAA) Marine Debris Program. The...

  8. CHIP Reauthorization Act of 2009 (CHIPRA)

    Data.gov (United States)

    U.S. Department of Health & Human Services — One of the clear goals of the Childrens Health Insurance Program Reauthorization Act of 2009 is to support states in developing efficient and effective strategies to...

  9. Comprehensive Environmental Response, Compensation and Liability Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data represents geographic terms used within the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). CERCLA, commonly known as...

  10. Speech Act Classification of German Advertising Texts

    OpenAIRE

    Артур Нарманович Мамедов

    2015-01-01

    This paper uses the theory of speech acts and the underlying concept of pragmalinguistics to determine the types of speech acts and their classification in the German advertising printed texts. We ascertain that the advertising of cars and accessories, household appliances and computer equipment, watches, fancy goods, food, pharmaceuticals, and financial, insurance, legal services and also airline advertising is dominated by a pragmatic principle, which is based on demonstrating information a...

  11. The ACTS Center for Software Sustainability

    Energy Technology Data Exchange (ETDEWEB)

    Leroy, Drummond-Lewis [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Marques, Osni A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2011-09-30

    This report covers the activities carried out by the project The ACTS Center for Software Sustainability, whose proposal was submitted to ASCR in 2007. These activities have their roots in the project Advanced Computational Testing Software (ACTS) Toolkit, which was part of the DOE2000 Program. Driven by the state of the software, the technology and the nature of the tools in the Toolkit, the project was reformulated in a project that better represented the goals and activities within ACTS, An Expanded Framework for the Advanced CompuTational Software (ACTS) Collection. At the heart of this project was the consolidation of lessons learned and demands from the computational science community that guided us to the creation of the now well-known DOE ACTS Collection. The goal of the project was to increase the pay-off of DOE ASCR investment in the development of the general purpose tools in the DOE ACTS Collection, reduce the duplication of efforts, and minimize the development time of high-end computer applications while maximizing the life of the codes.

  12. Obstacles to early career psychiatrists practicing psychotherapy.

    Science.gov (United States)

    Clemens, Norman A; Plakun, Eric M; Lazar, Susan G; Mellman, Lisa

    2014-09-01

    Though psychiatric residents are expected to be competent psychotherapists on graduation, further growth in skill and versatility requires continued experience in their ongoing career. Maturity as a psychotherapist is essential because a psychiatrist is the only mental health provider who, as a physician, can assume full responsibility for biopsychosocial patient care and roles as supervisor, consultant, and team leader. Graduating residents face an environment in which surveys show a steady and alarming decline in practice of psychotherapy by psychiatrists, along with a decline in job satisfaction. High educational debts, practice structures, intrusive management, and reimbursement policies that devalue psychotherapy discourage early career psychiatrists from a practice style that enables providing it. For the early-career psychiatrist there is thus the serious risk of being unable to develop a critical mass of experience or a secure identity as a psychiatric psychotherapist. Implementation of parity laws and the Affordable Care Act (ACA) will affect the situation in unpredictable ways that call for vigilance and active response. Additional service and administrative demands may result from the ACA, creating ethical dilemmas about meeting urgent patient needs versus biopsychosocial standards of care. The authors recommend 1) vigorous advocacy for better payment levels for psychotherapy and freedom from disruptive management; 2) aggressive action against violations of the parity act, 3) active preparation of psychiatric residents for dealing with career choices and the environment for providing psychotherapy in their practice, and 4) post-graduate training in psychotherapy through supervision/consultation, continuing education courses, computer instruction, and distance learning.

  13. 75 FR 82382 - Beaches Environmental Assessment and Coastal Health Act

    Science.gov (United States)

    2010-12-30

    ... AGENCY Beaches Environmental Assessment and Coastal Health Act AGENCY: Environmental Protection Agency... Water Act (CWA) as amended by the Beaches Environmental Assessment and Coastal Health (BEACH) Act... Environmental Assessment and Coastal Health (BEACH) Act of 2000 amends the Clean Water Act to better protect...

  14. 75 FR 1373 - Beaches Environmental Assessment and Coastal Health Act

    Science.gov (United States)

    2010-01-11

    ... AGENCY Beaches Environmental Assessment and Coastal Health Act AGENCY: Environmental Protection Agency... Water Act (CWA) as amended by the Beaches Environmental Assessment and Coastal Health (BEACH) Act... Environmental Assessment and Coastal Health (BEACH) Act of 2000 amends the Clean Water Act to better protect...

  15. 43 CFR 2.47 - Records subject to Privacy Act.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Records subject to Privacy Act. 2.47 Section 2.47 Public Lands: Interior Office of the Secretary of the Interior RECORDS AND TESTIMONY; FREEDOM OF INFORMATION ACT Privacy Act § 2.47 Records subject to Privacy Act. The Privacy Act applies to all...

  16. Does valence matter? Effects of negativity on children's early understanding of the truth and lies

    Science.gov (United States)

    Wandrey, Lindsay; Quas, Jodi A.; Lyon, Thomas D.

    2014-01-01

    Early deceptive behavior often involves acts of wrongdoings on the part of children. As a result, it has often been assumed, although not tested directly, that children are better at identifying lies about wrongdoing than lies about other activities. We tested this assumption in two studies. In Study 1, 67 3- to 5-year-olds viewed vignettes in which a character truthfully or falsely claimed to have committed a good or bad act. Children were biased to label claims that the character had committed a good act as the truth and claims that the character had committed a bad act as lies. In Study 2, 51 4- to 6-year-olds viewed vignettes in which characters either admitted or denied committing a good or bad act. Children were better at identifying truth-tellers and liars when the acts were good. Results suggest that young children initially overgeneralize the concept of lie to include all negative acts and the concept of the truth to include all good acts and only gradually make a distinction between act valence and honesty. As a result, including wrongdoing in scenarios to test children's early understanding of the meaning of lying is likely to underestimate children's abilities. PMID:22819518

  17. Redefining early gastric cancer.

    Science.gov (United States)

    Barreto, Savio G; Windsor, John A

    2016-01-01

    The problem is that current definitions of early gastric cancer allow the inclusion of regional lymph node metastases. The increasing use of endoscopic submucosal dissection to treat early gastric cancer is a concern because regional lymph nodes are not addressed. The aim of the study was thus to critically evaluate current evidence with regard to tumour-specific factors associated with lymph node metastases in "early gastric cancer" to develop a more precise definition and improve clinical management. A systematic and comprehensive search of major reference databases (MEDLINE, EMBASE, PubMed and the Cochrane Library) was undertaken using a combination of text words "early gastric cancer", "lymph node metastasis", "factors", "endoscopy", "surgery", "lymphadenectomy" "mucosa", "submucosa", "lymphovascular invasion", "differentiated", "undifferentiated" and "ulcer". All available publications that described tumour-related factors associated with lymph node metastases in early gastric cancer were included. The initial search yielded 1494 studies, of which 42 studies were included in the final analysis. Over time, the definition of early gastric cancer has broadened and the indications for endoscopic treatment have widened. The mean frequency of lymph node metastases increased on the basis of depth of infiltration (mucosa 6% vs. submucosa 28%), presence of lymphovascular invasion (absence 9% vs. presence 53%), tumour differentiation (differentiated 13% vs. undifferentiated 34%) and macroscopic type (elevated 13% vs. flat 26%) and tumour diameter (≤2 cm 8% vs. >2 cm 25%). There is a need to re-examine the diagnosis and staging of early gastric cancer to ensure that patients with one or more identifiable risk factor for lymph node metastases are not denied appropriate chemotherapy and surgical resection.

  18. The Nuclear Waste Policy Act, as amended, with appropriations acts appended. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-02-01

    This act provides for the development of repositories for the disposal of high-level radioactive wastes, low-level radioactive wastes, and spent nuclear fuels. In addition, it establishes research and development programs, as well as demonstration programs regarding the disposal of these wastes. This Act consists of the Act of Jan. 7, 1983 (Public Law 97-425; 96 Stat. 2201), as amended by Public Law 100-203 and Public Law 102-486.

  19. The 2015 Budget Act and proposals for amendments of the Budget Act in Poland

    Directory of Open Access Journals (Sweden)

    Andrzej Borodo

    2015-03-01

    Full Text Available The article presents the legal content and system of the 2015 Budget Act and the legal significance of its regulations. In the paper there are also proposals to the new structure Polish Budget Act. The present system of the Budget Act does not include the revenues and expenditure of certain state funds (especially the National Road Fund and finances of State Treasury companies. The current system weakens the control function and budgetary power of the Parliament. New Polish system of the Budget Act should contain the general budget and several special budgets.

  20. 75 FR 52300 - Merchant Marine Act and Magnuson-Stevens Fishery Conservation and Management Act Provisions...

    Science.gov (United States)

    2010-08-25

    ...-Stevens Fishery Conservation and Management Act Provisions; Fishing Vessel, Fishing Facility and... the Fisheries Finance Program's programmatic regulations. The proposed rule was published with an...

  1. Inspecting Underground Storage Tanks - 2005 Energy Policy Act

    Science.gov (United States)

    these grant guidelines implement the inspection provisions in Sections 9005(c)(1) and 9005(c)(2) of the Solid Waste Disposal Act, enacted by the Underground Storage Tank Compliance Act, part of the Energy Policy Act of 2005.

  2. Public Record About Underground Storage Tanks - 2005 Energy Policy Act

    Science.gov (United States)

    These grant guidelines implement the public record provision in Section 9002(d) of the Solid Waste Disposal Act, enacted by the Underground Storage Tank Compliance Act, part of the Energy Policy Act of 2005.

  3. 77 FR 4643 - Freedom of Information Act Implementation

    Science.gov (United States)

    2012-01-31

    ... RIN 2590-AA44 Freedom of Information Act Implementation AGENCY: Federal Housing Finance Agency. ACTION... existing Freedom of Information Act (FOIA) regulation. This final regulation provides procedures and... action, Freedom of Information Act, Judicial review, Records, Requests. Authority and Issuance...

  4. Early diagnosis of early stage lung cancer

    Directory of Open Access Journals (Sweden)

    Andrej Debeljak

    2005-11-01

    Full Text Available Background: For the detection of premalignant changes of bronchial mucosa and early stages of lung cancer frequent chest X-ray, spiral low dose computed tomography, fluorescence bronchoscopy, sputum cytology (also with automated systems with genetic and molecular changes in the sputum cells and bronchial mucosa were used. These screening methods of the high-risk groups for lung cancer achieved: earlier diagnosis of lung cancer in lower stage, higher operability, longer 5-year survival, but without mortality reduction.Conclusions: In the clinical practice we can examine higher risk groups for lung cancer in randomised control trials with multimodality approach: frequent chest low-dose fast spiral computed tomography, sputum cytology with genetic and molecular examinations and fluorescence bronchoscopy. Smoking cessation remains the best means to achieve mortality reduction from lung cancer.

  5. KLF10, transforming growth factor-{beta}-inducible early gene 1, acts as a tumor suppressor

    Energy Technology Data Exchange (ETDEWEB)

    Song, Ki-Duk [Center for Agricultural Biomaterials, Seoul National University, Seoul 151-921 (Korea, Republic of); Laboratory of Protein Engineering and Comparative Immunology, School of Agricultural Biotechnology, Seoul National University, Seoul 151-921 (Korea, Republic of); Kim, Duk-Jung [The Institute of Hankook Life Science, 7-9 Myungryun-dong, Jongno-gu, Seoul 110-521 (Korea, Republic of); Lee, Jong Eun [Department of Anatomy, College of Medicine, Yonsei University, Seoul 120-752 (Korea, Republic of); Yun, Cheol-Heui [Center for Agricultural Biomaterials, Seoul National University, Seoul 151-921 (Korea, Republic of); Laboratory of Protein Engineering and Comparative Immunology, School of Agricultural Biotechnology, Seoul National University, Seoul 151-921 (Korea, Republic of); Lee, Woon Kyu, E-mail: wklee@inha.ac.kr [Laboratory of Developmental Genetics, School of Medicine, Inha University, Incheon 400-712 (Korea, Republic of); Brain Korea 21 Center for Advanced Medical Education, School of Medicine, Inha University, Incheon 400-712 (Korea, Republic of)

    2012-03-09

    Highlights: Black-Right-Pointing-Pointer KLF10{sup -/-} mice exhibited accelerated papilloma development after DMBA/TPA treatment. Black-Right-Pointing-Pointer KLF10{sup -/-} keratinocytes showed increased proliferation and apoptosis. Black-Right-Pointing-Pointer KLF10{sup -/-} MEFs yielded more colonies than wild-type one with H-Ras transfection. Black-Right-Pointing-Pointer KLF10 dose-dependently activated p21{sup WAF1/CIP1} transcription. Black-Right-Pointing-Pointer KLF10 is a tumor suppressor and that it targets p21{sup WAF1/CIP1} transcription. -- Abstract: Krueppel-like factor 10 (KLF10) has been suggested to be a putative tumor suppressor. In the present study, we generated KLF10 deficient mice to explore this hypothesis in vivo. KLF10 deficient mice exhibited increased predisposition to skin tumorigenesis and markedly accelerated papilloma development after DMBA/TPA treatment. On the other hand, KLF10 deficient keratinocytes showed increased proliferation and apoptosis. In colony formation assays after oncogenic H-Ras transfection, KLF10 deficient mouse embryonic fibroblasts (MEFs) yielded more colonies than wild-type MEFs. Furthermore, KLF10 dose-dependently activated p21{sup WAF1/CIP1} transcription, which was independent of p53 and Sp1 binding sites in p21{sup WAF1/CIP1} promoter. This study demonstrates that KLF10 is a tumor suppressor and that it targets p21{sup WAF1/CIP1} transcription.

  6. Acting Like a Mathematician: A Project to Encourage Inquiry Early in the Math Major

    Science.gov (United States)

    Camenga, Kristin A.

    2017-01-01

    Inquiry is promoted as a way to engage students so that they learn more deeply; inquiry is also an end in itself, introducing students to the research process and the behaviors of a mathematician. This article reflects on an individual exploratory project used in a sophomore-level number theory course, examining how it supported student inquiry…

  7. Early Warning Signs of Suicide in Service Members Who Engage in Unauthorized Acts of Violence

    Science.gov (United States)

    2016-06-01

    appearance (manner of dress, hairstyle, posture, etc.) or hygiene (bathing habits, brushing teeth /hair, etc.) Social Interest in leisure activities...REPORT NUMBER(S): 12. DISTRIBUTION/AVAILABILITY STATEMENT: (A) Distribution Unlimited 13. SUPPLEMENTARY NOTES: ABSTRACT: Despite the importance of... important step for identifying and managing individuals who pose a threat to themselves or others (Meloy et al., 2004; Rudd, 2006). Threat assessment, used

  8. Sequentially acting Sox transcription factors in neural lineage development.

    Science.gov (United States)

    Bergsland, Maria; Ramsköld, Daniel; Zaouter, Cécile; Klum, Susanne; Sandberg, Rickard; Muhr, Jonas

    2011-12-01

    Pluripotent embryonic stem (ES) cells can generate all cell types, but how cell lineages are initially specified and maintained during development remains largely unknown. Different classes of Sox transcription factors are expressed during neurogenesis and have been assigned important roles from early lineage specification to neuronal differentiation. Here we characterize the genome-wide binding for Sox2, Sox3, and Sox11, which have vital functions in ES cells, neural precursor cells (NPCs), and maturing neurons, respectively. The data demonstrate that Sox factor binding depends on developmental stage-specific constraints and reveal a remarkable sequential binding of Sox proteins to a common set of neural genes. Interestingly, in ES cells, Sox2 preselects for neural lineage-specific genes destined to be bound and activated by Sox3 in NPCs. In NPCs, Sox3 binds genes that are later bound and activated by Sox11 in differentiating neurons. Genes prebound by Sox proteins are associated with a bivalent chromatin signature, which is resolved into a permissive monovalent state upon binding of activating Sox factors. These data indicate that a single key transcription factor family acts sequentially to coordinate neural gene expression from the early lineage specification in pluripotent cells to later stages of neuronal development.

  9. Rad51 activates polyomavirus JC early transcription.

    Directory of Open Access Journals (Sweden)

    Martyn K White

    Full Text Available The human neurotropic polyomavirus JC (JCV causes the fatal CNS demyelinating disease progressive multifocal leukoencephalopathy (PML. JCV infection is very common and after primary infection, the virus is able to persist in an asymptomatic state. Rarely, and usually only under conditions of immune impairment, JCV re-emerges to actively replicate in the astrocytes and oligodendrocytes of the brain causing PML. The regulatory events involved in the reactivation of active viral replication in PML are not well understood but previous studies have implicated the transcription factor NF-κB acting at a well-characterized site in the JCV noncoding control region (NCCR. NF-κB in turn is regulated in a number of ways including activation by cytokines such as TNF-α, interactions with other transcription factors and epigenetic events involving protein acetylation--all of which can regulate the transcriptional activity of JCV. Active JCV infection is marked by the occurrence of rapid and extensive DNA damage in the host cell and the induction of the expression of cellular proteins involved in DNA repair including Rad51, a major component of the homologous recombination-directed double-strand break DNA repair machinery. Here we show that increased Rad51 expression activates the JCV early promoter. This activation is co-operative with the stimulation caused by NF-κB p65, abrogated by mutation of the NF-κB binding site or siRNA to NFκB p65 and enhanced by the histone deacetylase inhibitor sodium butyrate. These data indicate that the induction of Rad51 resulting from infection with JCV acts through NF-κB via its binding site to stimulate JCV early transcription. We suggest that this provides a novel positive feedback mechanism to enhance viral gene expression during the early stage of JCV infection.

  10. Diabetes and the Affordable Care Act.

    Science.gov (United States)

    Burge, Mark R; Schade, David S

    2014-07-01

    The Affordable Care Act--"Obamacare"--is the most important federal medical legislation to be enacted since Medicare. Although the goal of the Affordable Care Act is to improve healthcare coverage, access, and quality for all Americans, people with diabetes are especially poised to benefit from the comprehensive reforms included in the act. Signed into law in 2010, this massive legislation will slowly be enacted over the next 10 years. In the making for at least a decade, it will affect every person in the United States, either directly or indirectly. In this review, we discuss the major changes in healthcare that will take place in the next several years, including (1) who needs to purchase insurance on the Web-based exchange, (2) the cost to individuals and the rebates that they may expect, (3) the rules and regulations for purchasing insurance, (4) the characteristics of the different "metallic" insurance plans that are available, and (5) the states that have agreed to participate. With both tables and figures, we have tried to make the Affordable Care Act both understandable and appreciated. The goal of this comprehensive review is to highlight aspects of the Affordable Care Act that are of importance to practitioners who care for people with diabetes by discussing both the positive and the potentially negative aspects of the program as they relate to diabetes care.

  11. Coronavirus cis-Acting RNA Elements.

    Science.gov (United States)

    Madhugiri, R; Fricke, M; Marz, M; Ziebuhr, J

    2016-01-01

    Coronaviruses have exceptionally large RNA genomes of approximately 30 kilobases. Genome replication and transcription is mediated by a multisubunit protein complex comprised of more than a dozen virus-encoded proteins. The protein complex is thought to bind specific cis-acting RNA elements primarily located in the 5'- and 3'-terminal genome regions and upstream of the open reading frames located in the 3'-proximal one-third of the genome. Here, we review our current understanding of coronavirus cis-acting RNA elements, focusing on elements required for genome replication and packaging. Recent bioinformatic, biochemical, and genetic studies suggest a previously unknown level of conservation of cis-acting RNA structures among different coronavirus genera and, in some cases, even beyond genus boundaries. Also, there is increasing evidence to suggest that individual cis-acting elements may be part of higher-order RNA structures involving long-range and dynamic RNA-RNA interactions between RNA structural elements separated by thousands of nucleotides in the viral genome. We discuss the structural and functional features of these cis-acting RNA elements and their specific functions in coronavirus RNA synthesis. © 2016 Elsevier Inc. All rights reserved.

  12. Introduction to "Early psychosis

    DEFF Research Database (Denmark)

    McGorry, Patrick; Nordentoft, Merete; Simonsen, Erik

    2005-01-01

    Early intervention in psychiatry has taken a long time to emerge as a key strategy to reduce morbidity and mortality. In other fields of medicine it has received consistent support and great efforts are expended to educate the public about the value of early diagnosis and the benefits of timely...... intervention. There is finally substantial momentum behind similar endeavours in psychotic disorders, which, now they have reached "proof of concept" stage, could begin to be extended across the spectrum of serious mental disorders. There is also ambivalence and resistance to this evidence-based reform which...

  13. Early Islamic Syria

    DEFF Research Database (Denmark)

    Walmsley, Alan

    After more than a century of neglect, a profound revolution is occurring in the way archaeology addresses and interprets developments in the social history of early Islamic Syria-Palestine. This concise book offers an innovative assessment of social and economic developments in Syria-Palestine...... for considerable cultural and economic continuity rather than devastation and unrelenting decline. Much new, and increasingly non-elite, architectural evidence and an ever-growing corpus of material culture indicate that Syria-Palestine entered a new age of social richness in the early Islamic period, even...

  14. Early life vaccination

    DEFF Research Database (Denmark)

    Nazerai, Loulieta; Bassi, Maria Rosaria; Uddbäck, Ida Elin Maria

    2016-01-01

    the first period of life and provide a pertinent alternative in infant vaccinology. To address this, infant mice were vaccinated with three different adenoviral vectors and the CD8+ T-cell response after early life vaccination was explored. We assessed the frequency, polyfunctionality and in vivo...... cytotoxicity of the elicited memory CD8+ T cells, as well as the potential of these cells to respond to secondary infections and confer protection. We further tested the impact of maternal immunity against our replication-deficient adenoviral vector during early life vaccination. Overall, our results indicate...

  15. Federal Funding Accountability and Transparency Act frequently asked questions

    Science.gov (United States)

    One stop shop for Federal Funding Accountability and Transparency Act (FFATA) questions. This frequently asked document will assist with Federal Funding Accountability and Transparency Act (FFATA) related questions.

  16. Early intervention for infants and toddlers: Applications for pediatric oncology.

    Science.gov (United States)

    Harman, Jennifer L; Wise, Jillian; Willard, Victoria W

    2017-12-22

    Young children (<3 years) with cancer are at risk for delays in development due to their disease and its required treatments and restrictions. In the United States, Part C of the Individuals with Disabilities Education Act describes a system of early intervention (EI) services for young children with delays or the potential for delays in development. Children with cancer may be eligible for EI but are rarely referred. Our objectives are to describe the critical impact of early childhood development on long-term outcomes, review current considerations for EI, and advocate for the referral to EI for young children with cancer. © 2017 Wiley Periodicals, Inc.

  17. Nomadic Research Practices in Early Childhood: Interrupting Racisms and Colonialisms

    Directory of Open Access Journals (Sweden)

    Veronica Pacini-Ketchabaw

    2011-12-01

    Full Text Available This paper considers how research practices on racialization in early childhood education might be reconceptualized when racialization is placed within relational intricacies and affects in multiple encounters. By foregrounding race and its emergence in multifarious, unpredictable ways in everyday encounters between human and non-human bodies, space, and discourse, the paper investigates how a movement toward research analyses that engage with both the materiality of race and its systemic and discursive formations might be used to constantly seek new ethical ways of responding to and acting against racisms and colonialism in early childhood.

  18. Zoological Nomenclature and Speech Act Theory

    Science.gov (United States)

    Cambefort, Yves

    To know natural objects, it is necessary to give them names. This has always been done, from antiquity up to modern times. Today, the nomenclature system invented by Linnaeus in the eighteenth century is still in use, even if the philosophical principles underlying it have changed. Naming living objects still means giving them a sort of existence, since without a name they cannot be referred to, just as if they did not exist. Therefore, naming a living object is a process close to creating it. Naming is performed by means of a particular kind of text: original description written by specialists, and more often accompanied by other, ancillary texts whose purpose is to gain the acceptance and support of fellow zoologists. It is noteworthy that the actions performed by these texts are called "nomenclatural acts". These texts and acts, together with related scientific and social relationships, are examined here in the frame of speech act theory.

  19. 75 FR 20830 - Early Learning

    Science.gov (United States)

    2010-04-21

    ... Early Learning AGENCY: Office of the Secretary, Department of Education. ACTION: Notice of public..., is seeking input from State agencies responsible for early learning and development, families..., researchers of early learning, stakeholders who work with early learning and development for young children...

  20. "Before We Teach It, We Have to Learn It": Wisconsin Act 31 Compliance within Public Teacher Preparation Programs

    Science.gov (United States)

    Moody, Heather Ann

    2013-01-01

    Wisconsin Act 31 was established for the purpose of addressing American Indian history, culture, and sovereignty within K-12 schools as a response to treaty rights issues in the late 1970s and early 1980s. Yet, in the 21 st century there remain issues with compliance throughout not only K-12 schools but also institutions of higher education. The…

  1. 76 FR 64115 - Privacy Act of 1974; Privacy Act System of Records

    Science.gov (United States)

    2011-10-17

    ... Rehabilitation Act of 1973, as amended, or the Genetic Information Nondiscrimination Act of 2008 (GINA); (6... Program. SECURITY CLASSIFICATION: None. SYSTEM LOCATION: The American Society for Engineering Education... Management, Office of Government Ethics, and Merit Systems Protection Board for investigation of possible...

  2. 78 FR 29659 - Forfeiture Procedures Under the Endangered Species Act and the Lacey Act Amendments

    Science.gov (United States)

    2013-05-21

    ....S.C. 1531 et seq.), was passed to prevent the extinction of native and non- native animals and... Animal and Plant Health Inspection Service 7 CFR Part 356 RIN 0579-AD50 Forfeiture Procedures Under the Endangered Species Act and the Lacey Act Amendments AGENCY: Animal and Plant Health Inspection Service, USDA...

  3. 76 FR 18365 - Fair Credit Reporting Act and Bank Secrecy Act Compliance

    Science.gov (United States)

    2011-04-04

    ... Procedure Act (APA), an agency may, for good cause, find (and incorporate the finding and a brief statement... and comment procedures prescribed by the APA are unnecessary because the final rule makes technical..., and the FFIEC Bank Secrecy Act/Anti-Money Laundering Examination Manual. (iii) Compliance. Failure to...

  4. 78 FR 25685 - Magnuson-Stevens Act Provisions; Implementation of the Shark Conservation Act of 2010

    Science.gov (United States)

    2013-05-02

    ... Provisions; Implementation of the Shark Conservation Act of 2010 AGENCY: National Marine Fisheries Service... for comments. SUMMARY: NMFS proposes a rule to implement the provisions of the Shark Conservation Act of 2010 (SCA) and prohibit any person from removing any of the fins of a shark at sea, possessing...

  5. The adaptor molecule Act1 regulates BAFF responsiveness and self-reactive B cell selection during transitional B cell maturation

    Science.gov (United States)

    Giltiay, Natalia V.; Lu, Yi; Allman, David; Jørgensen, Trine N.; Li, Xiaoxia

    2011-01-01

    The transitional stage is a key check-point for elimination of autoreactive B cells in the periphery. This selection process requires fine regulation of signals received through B-cell receptor (BCR) and B cell activating factor receptor (BAFFR). We previously identified the adaptor molecule Act1 as a negative regulator of BAFF-mediated signaling. Deficiency of Act1 in mice results in peripheral B cell hyperplasia and development of autoimmunity. In this study we demonstrate that Act1 plays a critical role in the regulation of transitional B cell survival and maturation. We found that the ratio of late-transitional (T2) to early-transitional (T1) cells was increased in spleens from Act1-deficient mice. Moreover, BAFF stimulation induced better T1 cell survival and promoted more efficient maturation of T1 cells into T2 cells ex vivo in the absence of Act1. BAFF stimulation induced higher levels of the anti-apoptotic Bcl2-member Mc1-l in Act1-deficient T1 than that in wild-type control cells, suggesting that Mcl1 might be one of the key effector molecules for BAFF-mediated survival in the Act1-deficient transitional B cells. Importantly, co-stimulation with BAFF was able to rescue Act1-deficient T1 cells from BCR-induced apoptosis more effectively than Act1-suffienct T1 B cells. Finally, by using double transgenic HEL mice, we demonstrated that Act1 deficiency can promote the maturation of HEL-specific autoreactive B cells. Taken together, our results suggest that the transitional stage is a critical point of action for Act1 in the elimination of autoreactive B cells and in the regulation of peripheral B cell homeostasis. PMID:20543113

  6. Early Islamic Syria

    DEFF Research Database (Denmark)

    Walmsley, Alan George

    This book presents a new interpretation of social and economic developments in Syria-Palestine in the decades before and during the two centuries after the Islamic expansion into the region (roughly the later 6th to the early 9th century AD). Drawing on a wide range of evidence from recent archae...

  7. Creativity: The Early Years

    Science.gov (United States)

    Shade, Rick; Shade, Patti Garrett

    2016-01-01

    There is a myth that some people are creative and others are not. However, all children are born creative. They love to explore, ask questions, and are incredibly imaginative. Parents are key in nurturing their child's creativity in the early years. This article offers resources and strategies parents can use at different ages and stages (newborn,…

  8. Teaching polymorphism early

    DEFF Research Database (Denmark)

    2005-01-01

    Is it possible to teach dynamic polymorphism early? What techniques could facilitate teaching it in Java. This panel will bring together people who have considered this question and attempted to implement it in various ways, some more completely than others. It will also give participants...

  9. Early hominin auditory capacities.

    Science.gov (United States)

    Quam, Rolf; Martínez, Ignacio; Rosa, Manuel; Bonmatí, Alejandro; Lorenzo, Carlos; de Ruiter, Darryl J; Moggi-Cecchi, Jacopo; Conde Valverde, Mercedes; Jarabo, Pilar; Menter, Colin G; Thackeray, J Francis; Arsuaga, Juan Luis

    2015-09-01

    Studies of sensory capacities in past life forms have offered new insights into their adaptations and lifeways. Audition is particularly amenable to study in fossils because it is strongly related to physical properties that can be approached through their skeletal structures. We have studied the anatomy of the outer and middle ear in the early hominin taxa Australopithecus africanus and Paranthropus robustus and estimated their auditory capacities. Compared with chimpanzees, the early hominin taxa are derived toward modern humans in their slightly shorter and wider external auditory canal, smaller tympanic membrane, and lower malleus/incus lever ratio, but they remain primitive in the small size of their stapes footplate. Compared with chimpanzees, both early hominin taxa show a heightened sensitivity to frequencies between 1.5 and 3.5 kHz and an occupied band of maximum sensitivity that is shifted toward slightly higher frequencies. The results have implications for sensory ecology and communication, and suggest that the early hominin auditory pattern may have facilitated an increased emphasis on short-range vocal communication in open habitats.

  10. Prenatal depression: Early intervention.

    Science.gov (United States)

    Anderson, Cheryl A; Lieser, Carol

    2015-07-15

    Frequently undiagnosed and untreated, prenatal depression affects approximately one in four childbearing women. Screening and appropriate management is essential to prevent adverse consequences to both the woman and her unborn infant. Early conversations between the woman and her nurse practitioner are essential to making medical management decisions.

  11. Early Developments in Crystallography

    Indian Academy of Sciences (India)

    IAS Admin

    molecules to treat different diseases, make materials of desired properties and attempt to understand unknown territories far away from the Earth such as the exploration of the surface of. Mars. In this article, we will try to trace the early historical events in the development of X-ray crystallography, and the Indian contributions ...

  12. Early Mover Advantages

    NARCIS (Netherlands)

    G.E. Bijwaard (Govert); M.C.W. Janssen (Maarten); E. Maasland (Emiel)

    2004-01-01

    textabstractIn this paper we analyze empirically whether and if so to what extent later entrants in the European mobile telephony industry have a disadvantage vis-à-vis incumbents and early mover entrants. To analyze this question we consider a series of static models and a dynamic model of market

  13. Early Islamic Syria

    DEFF Research Database (Denmark)

    Walmsley, Alan George

    This book presents a new interpretation of social and economic developments in Syria-Palestine in the decades before and during the two centuries after the Islamic expansion into the region (roughly the later 6th to the early 9th century AD). Drawing on a wide range of evidence from recent...

  14. Early Childhood--Love

    Science.gov (United States)

    Jackson, Sylvia

    1976-01-01

    If children are to love themselves and others, they must experience love early. And they need to be taught the value of love, since it tends to fall victim to other lesser emotions. Provides suggestions for helping young children to grow in love. (Author/RK)

  15. Music in Early Childhood.

    Science.gov (United States)

    Feierabend, John

    1990-01-01

    Argues that music activities in early childhood education foster a variety of developmental skills. Analyzes Howard Gardner's theory of multiple intelligences, contending that music intelligence is a separate intelligence. Provides ways to identify and promote musical intelligence. Suggests methods for encouraging musical development. Using songs…

  16. Early hominin auditory capacities

    Science.gov (United States)

    Quam, Rolf; Martínez, Ignacio; Rosa, Manuel; Bonmatí, Alejandro; Lorenzo, Carlos; de Ruiter, Darryl J.; Moggi-Cecchi, Jacopo; Conde Valverde, Mercedes; Jarabo, Pilar; Menter, Colin G.; Thackeray, J. Francis; Arsuaga, Juan Luis

    2015-01-01

    Studies of sensory capacities in past life forms have offered new insights into their adaptations and lifeways. Audition is particularly amenable to study in fossils because it is strongly related to physical properties that can be approached through their skeletal structures. We have studied the anatomy of the outer and middle ear in the early hominin taxa Australopithecus africanus and Paranthropus robustus and estimated their auditory capacities. Compared with chimpanzees, the early hominin taxa are derived toward modern humans in their slightly shorter and wider external auditory canal, smaller tympanic membrane, and lower malleus/incus lever ratio, but they remain primitive in the small size of their stapes footplate. Compared with chimpanzees, both early hominin taxa show a heightened sensitivity to frequencies between 1.5 and 3.5 kHz and an occupied band of maximum sensitivity that is shifted toward slightly higher frequencies. The results have implications for sensory ecology and communication, and suggest that the early hominin auditory pattern may have facilitated an increased emphasis on short-range vocal communication in open habitats. PMID:26601261

  17. Early childhood aggression

    NARCIS (Netherlands)

    Alink, Lenneke Rosalie Agnes

    2006-01-01

    In this thesis the development, stability, and correlates of early childhood aggression were investigated. The normative development was examined in a general population sample using questionnaires completed by the parents of 12-, 24-, and 36-month-old children and again one year later. Results

  18. Early Childhood Trauma

    Science.gov (United States)

    National Child Traumatic Stress Network, 2010

    2010-01-01

    Early childhood trauma generally refers to the traumatic experiences that occur to children aged 0-6. Because infants' and young children's reactions may be different from older children's, and because they may not be able to verbalize their reactions to threatening or dangerous events, many people assume that young age protects children from the…

  19. Early Option Exercise

    DEFF Research Database (Denmark)

    Heje Pedersen, Lasse; Jensen, Mads Vestergaard

    A classic result by Merton (1973) is that, except just before expiration or dividend payments, one should never exercise a call option and never convert a convertible bond. We show theoretically that this result is overturned when investors face frictions. Early option exercise can be optimal whe...

  20. Early intervention in psychosis

    DEFF Research Database (Denmark)

    Csillag, Claudio; Nordentoft, Merete; Mizuno, Masafumi

    2017-01-01

    AIM: Early intervention in psychosis (EIP) is a well-established approach with the intention of early detection and treatment of psychotic disorders. Its clinical and economic benefits are well documented. This paper presents basic aspects of EIP services, discusses challenges to their implementa......AIM: Early intervention in psychosis (EIP) is a well-established approach with the intention of early detection and treatment of psychotic disorders. Its clinical and economic benefits are well documented. This paper presents basic aspects of EIP services, discusses challenges...... implemented EIP services into the mental healthcare system have generated evidence, concepts and specific strategies that might serve as guidance or inspiration in other countries or systems where EIP is less well developed or not developed at all. Previous experience has made clear that evidence of clinical...... benefits alone is not enough to promote implementation, as economic arguments and political and social pressure have shown to be important elements in efforts to achieve implementation. CONCLUSIONS: Users' narratives, close collaboration with community organizations and support from policy-makers and known...

  1. [Mental disorders and dangerous acting out].

    Science.gov (United States)

    Bouchard, Jean-Pierre

    2015-01-01

    The major mental disorders which are most likely to lead to dangerous acting out are adult psychoses (schizophrenia and paranoia) and severe mood disorders (major depressive episodes and mania). Good knowledge of the symptomatology of these pathologies and their identification can help to anticipate and prevent much of the violence which people with these disorders may inflict on others or themselves. After mental assessment, those who commit wrongful and criminal acts may be ruled to be criminally irresponsible. They are then handed over to the relevant health care authorities for treatment for their mental disorders.

  2. The Competition in Contracting Act of 1984

    Science.gov (United States)

    1986-06-01

    the Competition in Contracting Act of 1984 was essentially a merger of two separate bills, the Senate version known as S. 338 and the House of...Procurement Reform Act of 1983", introduced on April 13, 1983 could also be included as part of the merger . This bill, however, addressed only Department of...3Testimony of The Hotorable John F Lehman. Jr.. Secretury of the Navy Before the House Acquisitio . aad Procurement Policy Panel on 9 April 1986. 77 years.’ 4

  3. Ment, llenguatge i actes de parla

    OpenAIRE

    Giménez de la Prada, Àlex

    2014-01-01

    Conté: treball de recerca, pòster i resum executiu Aquest treball tracta, a mode d'assaig, d'oferir una possible explicació dels mecanismes que permeten l'execució d'actes de parla. Per a fer-ho, es comparen, bàsicament, dos models: el model dels actes de parla de John R. Searle (1969 i 1979) i l'explicació que Steven Pinker (2007) donar en referència a l'aprenentatge del llenguatge i al “llenguatge del pensament”. Aquest treball intenta vincular aquestes dues teories, de manera que la teo...

  4. Generalization as creative and reflective act

    DEFF Research Database (Denmark)

    Tateo, Luca

    2013-01-01

    It is argued that generalization in psychology is a creative, interpretative, and reflective act of thought, by accessing a higher level of abstraction from meaningful events. In the context of clarification of this claim, a fresh look at Lewin’s argumentation about the “Aristotelian” and “Galile......It is argued that generalization in psychology is a creative, interpretative, and reflective act of thought, by accessing a higher level of abstraction from meaningful events. In the context of clarification of this claim, a fresh look at Lewin’s argumentation about the “Aristotelian...

  5. Significance of past statements: speech act theory.

    Science.gov (United States)

    Gordon, Joanne

    2013-09-01

    In W v M, a judge concluded that M's past statements should not be given weight in a best interests assessment. Several commentators in the ethics literature have argued this approach ignored M's autonomy. In this short article I demonstrate how the basic tenets of speech act theory can be used to challenge the inherent assumption that past statements represent an individual's beliefs, choices or decisions. I conclude that speech act theory, as a conceptual tool, has a valuable contribution to make to this debate.

  6. Telerehabilitation: An Adjunct Service Delivery Model for Early Intervention Services

    OpenAIRE

    Jana Cason

    2011-01-01

    Early Intervention (EI) services for children birth through two years of age are mandated by Part C of the Individuals with Disabilities Education Act (IDEA); however, personnel shortages, particularly in rural areas, limit access for children who qualify. Telerehabilitation has the potential to build capacity among caregivers and local providers as well as promote family-centered services through remote consultation.  This article provides an overview of research related to telerehabili...

  7. Every Student Succeeds Act and Arts Education

    Science.gov (United States)

    Kohn Bradley, Karen

    2016-01-01

    Dance educators will be pleased to know that there is new legislation at the federal level that supports arts education. Seven years after Congress was due to reauthorize the Elementary and Secondary Education Act (also known for eight + seven years as No Child Left Behind [NCLB]), the lawmakers, suddenly and surprisingly, came through with a new…

  8. Diabetes and the Affordable Care Act

    Science.gov (United States)

    Schade, David S.

    2014-01-01

    Abstract The Affordable Care Act—“Obamacare”—is the most important federal medical legislation to be enacted since Medicare. Although the goal of the Affordable Care Act is to improve healthcare coverage, access, and quality for all Americans, people with diabetes are especially poised to benefit from the comprehensive reforms included in the act. Signed into law in 2010, this massive legislation will slowly be enacted over the next 10 years. In the making for at least a decade, it will affect every person in the United States, either directly or indirectly. In this review, we discuss the major changes in healthcare that will take place in the next several years, including (1) who needs to purchase insurance on the Web-based exchange, (2) the cost to individuals and the rebates that they may expect, (3) the rules and regulations for purchasing insurance, (4) the characteristics of the different “metallic” insurance plans that are available, and (5) the states that have agreed to participate. With both tables and figures, we have tried to make the Affordable Care Act both understandable and appreciated. The goal of this comprehensive review is to highlight aspects of the Affordable Care Act that are of importance to practitioners who care for people with diabetes by discussing both the positive and the potentially negative aspects of the program as they relate to diabetes care. PMID:24927108

  9. 75 FR 42792 - Sunshine Act Meetings

    Science.gov (United States)

    2010-07-22

    ... From the Federal Register Online via the Government Publishing Office POSTAL REGULATORY COMMISSION Sunshine Act Meetings TIME AND DATE: Wednesday, August 4, 2010 at 11 a.m. PLACE: Commission hearing room... of confidential personnel issues involving recruitment. 9. Discussion of contracts involving...

  10. 77 FR 57016 - Privacy Act; Implementation

    Science.gov (United States)

    2012-09-17

    ... the integrity of the security and counter-intelligence records by the Defense Intelligence Agency and... of the Secretary 32 CFR Part 319 Privacy Act; Implementation AGENCY: Defense Intelligence Agency, DoD. ACTION: Direct final rule with request for comments. SUMMARY: Defense Intelligence Agency (DIA) is...

  11. 78 FR 36602 - Sunshine Act Meeting; Notice

    Science.gov (United States)

    2013-06-18

    ... anniversary celebration planning. A verbatim transcript will be made of the closed session meeting of the... celebration planning. 8. Consider and act on adjournment of meeting. CONTACT PERSON FOR INFORMATION: Katherine... 14, 2013. Atitaya C. Rok, Staff Attorney. BILLING CODE 7050-01-P ...

  12. 78 FR 38076 - Sunshine Act Meeting

    Science.gov (United States)

    2013-06-25

    ... activities and LSC's 40th anniversary celebration planning. A verbatim transcript will be made of the closed... 40th anniversary celebration planning 8. Consider and act on adjournment of meeting CONTACT PERSON FOR... be fulfilled. Dated: June 21, 2013. Atitaya C. Rok, Staff Attorney. [FR Doc. 2013-15338 Filed 6-21-13...

  13. 75 FR 12583 - Sunshine Act; Meeting Notice

    Science.gov (United States)

    2010-03-16

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Sunshine Act; Meeting Notice Agency Holding the Meetings: Nuclear Regulatory Commission. Date..., 2010 9:30 a.m. Briefing on Safety Culture (Public Meeting) (Contact: Jose Ibarra, 301-415-2581). This...

  14. A karyopherin acts in localized protein synthesis

    NARCIS (Netherlands)

    Veenhoff, Liesbeth M.; Meinema, Anne C.; Poolman, Bert

    2010-01-01

    Multiple mechanisms are in place to regulate adequate synthesis of proteins, ranging from ways to ensure sequence fidelity, polypeptide folding and protein modification, to control of amounts and subcellular localization of the molecules. Some of these mechanisms act at the level of mRNA export and

  15. First Look: Act I on Dialog.

    Science.gov (United States)

    Copler, Judith A.

    1986-01-01

    Presents a description of Act I, the newest database from Data Courier, Inc., which provides an online directory of computer related companies and products. Highlights include content, applications, most useful features, classification code/classification name, and output. A sample record, journals list, and database specifications are included.…

  16. The Genetic Privacy Act and commentary

    Energy Technology Data Exchange (ETDEWEB)

    Annas, G.J.; Glantz, L.H.; Roche, P.A.

    1995-02-28

    The Genetic Privacy Act is a proposal for federal legislation. The Act is based on the premise that genetic information is different from other types of personal information in ways that require special protection. The DNA molecule holds an extensive amount of currently indecipherable information. The major goal of the Human Genome Project is to decipher this code so that the information it contains is accessible. The privacy question is, accessible to whom? The highly personal nature of the information contained in DNA can be illustrated by thinking of DNA as containing an individual`s {open_quotes}future diary.{close_quotes} A diary is perhaps the most personal and private document a person can create. It contains a person`s innermost thoughts and perceptions, and is usually hidden and locked to assure its secrecy. Diaries describe the past. The information in one`s genetic code can be thought of as a coded probabilistic future diary because it describes an important part of a unique and personal future. This document presents an introduction to the proposal for federal legislation `the Genetic Privacy Act`; a copy of the proposed act; and comment.

  17. 78 FR 73189 - Sunshine Act Meeting

    Science.gov (United States)

    2013-12-05

    ... Depository Institutions, under Title I of the Dodd-Frank Act, and 12 CFR 360.10. Memorandum and resolution re.../fdic/boardmeetings.asp to view the event. If you need any technical assistance, please visit our Video Help page at: http://www.fdic.gov/video.html . The FDIC will provide attendees with auxiliary aids (e.g...

  18. 78 FR 66893 - Sunshine Act Notice

    Science.gov (United States)

    2013-11-07

    ... Sunshine Act Notice AGENCY: United States Commission on Civil Rights. ACTION: Notice of Business Meeting... Regulatory and Other Barriers to Small Businesses'' Update on Status of the ``Civil Rights Implications of... Consideration of the inquiry letter to the Department of Defense on behalf of Sikh military members IV...

  19. 75 FR 17849 - Freedom of Information Act

    Science.gov (United States)

    2010-04-08

    ... the circumstances in which a freelance writer will be deemed to be working as a representative of the news media. Consistent with the OPEN Government Act, freelance writers will be regarded as... audience. A freelance journalist shall be regarded as working for a news media entity if the person can...

  20. Advance directives and the National Health Act

    African Journals Online (AJOL)

    also has the authority to refuse consent. David McQuUid-Masorl is Professor of Law at the Centre for ... When applied to refusal of treatment, advance directives usually take the form of 'living wills' 0r enduring powers ... method for the appointment of proxies to make health care decisions.4. National Health Act provisions.

  1. 75 FR 17898 - Sunshine Act Notice

    Science.gov (United States)

    2010-04-08

    ... Historically Black Colleges and Universities Approval of Letter to Youngstown, Ohio City Council Members re: Racially Bifurcated Test Results in the Police and Fire Departments Consideration Briefing Concept Paper on... Sunshine Act Notice AGENCY: United States Commission on Civil Rights. ACTION: Notice of meeting. DATE AND...

  2. 76 FR 16771 - Sunshine Act Meeting

    Science.gov (United States)

    2011-03-25

    .... OPEN AGENDA ITEMS: Item No. 1: Local Cost Policy. PUBLIC PARTICIPATION: The meeting will be open to... From the Federal Register Online via the Government Publishing Office EXPORT-IMPORT BANK OF THE UNITED STATES Sunshine Act Meeting ACTION: Notice of a Partially Open Meeting of the Board of Directors...

  3. Task Difficulty in Oral Speech Act Production

    Science.gov (United States)

    Taguchi, Naoko

    2007-01-01

    This study took a pragmatic approach to examining the effects of task difficulty on L2 oral output. Twenty native English speakers and 59 Japanese students of English at two different proficiency levels produced speech acts of requests and refusals in a role play task. The task had two situation types based on three social variables:…

  4. 75 FR 67396 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2010-11-02

    ... proposal regarding a research project. The Board will also receive briefings on an internal employment... unwarranted invasion of personal privacy. \\5\\ 45 CFR 1622.5(f) protects from disclosure investigatory records... proposal regarding a research project. 6. Consider and act on a Management recommendation regarding an...

  5. 75 FR 67145 - Sunshine Act: Public Hearing

    Science.gov (United States)

    2010-11-01

    ... From the Federal Register Online via the Government Publishing Office OVERSEAS PRIVATE INVESTMENT CORPORATION Sunshine Act: Public Hearing TIME AND DATE: 2 p.m., Wednesday, November 24, 2010. PLACE: Offices...: Hearing open to the Public at 2 p.m. PURPOSE: Public Hearing in conjunction with each meeting of OPIC's...

  6. 78 FR 1832 - Sunshine Act Meeting

    Science.gov (United States)

    2013-01-09

    ... identified in the investigation include the methods used to dispose of the fireworks, U.S. Government... the Senate. CSB investigations look into all aspects of accidents, including physical causes such as... INVESTIGATION BOARD Sunshine Act Meeting TIME AND DATE: January 17, 2013; 2:30 p.m. EST. PLACE: Ronald Reagan...

  7. 76 FR 72000 - Patent, Trademark & Copyright Acts

    Science.gov (United States)

    2011-11-21

    ... Geological Survey Patent, Trademark & Copyright Acts AGENCY: U.S. Geological Survey, Interior. ACTION: Notice...., Suite 200, Kennesaw, GA 30144, on U.S. Patent Application Serial No. 12/133,666, and a divisional patent application to be filed shortly at the Patent and Trademark Office, both entitled ``Anaerobic Microbial...

  8. Marketing the Job Training Partnership Act.

    Science.gov (United States)

    Markowicz, Arlene, Ed.; And Others

    1984-01-01

    This quarterly contains 11 bulletins that profile marketing campaigns for the Job Training Partnership Act (JTPA) that have been implemented successfully in local programs throughout the United States. For each program, the description provides information on the operator, funding, results, time span, background, marketing/public relations…

  9. 75 FR 18835 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2010-04-13

    .... Investment Policy Review. b. Vendor Financial Review. 4. Financial Audit Report. Parts Closed to the Public 5... INVESTMENT BOARD Sunshine Act Meeting Notice Time and Date: 9 a.m. (Eastern Time), April 19, 2010. Place: 4th... Investment Board. BILLING CODE 6760-01-P ...

  10. 77 FR 42313 - Sunshine Act Meetings

    Science.gov (United States)

    2012-07-18

    ... Reports. a. Investment Policy Report. b. Vendor Financial Status Report. 4. Risk Management Overview. 5... INVESTMENT BOARD Sunshine Act Meetings TIME AND DATE: July 23, 2012, 9:00 a.m. (Eastern Time). PLACE: 10th... Thrift Investment Board. BILLING CODE 6760-01-P ...

  11. ACT Plan: Technical Manual. 2013/2014

    Science.gov (United States)

    ACT, Inc., 2013

    2013-01-01

    This manual contains information about the American College Test (ACT) Plan® program. The principal focus of this manual is to document the Plan program's technical adequacy in light of its intended purposes. This manual supersedes the 2011 edition. The content of this manual responds to requirements of the testing industry as established in the…

  12. Business unusual - Waste Act implementation: solid waste

    CSIR Research Space (South Africa)

    Oelofse, Suzanna HH

    2013-08-01

    Full Text Available The preamble to the Waste Act (2008) is very clear that, as a result of this legislation, waste management in South Africa will never be the same again. This should send a clear message that ‘business as usual’ will no longer be sufficient....

  13. 77 FR 11534 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2012-02-27

    ...: Correction and Approval of the Minutes for the Meeting of February 16, 2012; Draft Advisory Opinion 2012-04: Justice Party of Mississippi; Draft Advisory Opinion 2012-03: ActRight; Draft Advisory Opinion 2012-01: Stop This Insanity, Inc. Employee Leadership Fund; Audit Division Recommendation Memorandum on Chris...

  14. 75 FR 54916 - Sunshine Act Meetings

    Science.gov (United States)

    2010-09-09

    ... Act based on a majority vote of the Council taken pursuant to electronic mail voting beginning on September 3. The timing of this meeting was prompted by the congruence of time-sensitive end-of-year budget... TO BE CONSIDERED: The agenda for this meeting is two-fold: (1) To discuss end-of-year final budget...

  15. 77 FR 6623 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2012-02-08

    ... Federal Motor Carrier Safety Administration Sunshine Act Meeting Notice AGENCY: Unified Carrier Registration Plan Board of Directors, Federal Motor Carrier Safety Administration (FMCSA), DOT. TIME AND DATE...) 827-4565. Issued on: February 2, 2012. Larry W. Minor, Associate Administrator for Policy. BILLING...

  16. Readers Want Reforms of Orphan Drug Act.

    Science.gov (United States)

    2017-06-01

    More than half (53%) of the 111 respondents to an online survey rated orphan drugs as having a major impact on rising drug costs, although there was also fairly wide (if mild) agreement that the 1983 Orphan Drug Act has been successful in creating incentives to develop remedies for rare diseases.

  17. 77 FR 60376 - Sunshine Act Notice

    Science.gov (United States)

    2012-10-03

    ... Sunshine Act Notice AGENCY: United States Commission on Civil Rights. ACTION: Notice of business meeting... Chief of Regional Programs' report OGC Training: Ethics Rules Relating to Teaching, Speaking, and... [email protected] at least seven business days before the scheduled date of the meeting. Dated: October 1...

  18. J. B. Adams Acting Director-General

    CERN Multimedia

    1960-01-01

    After the tragic death of Prof. C. J. Bakker, the Council of CERN held an emergency meeting on May 3, 1960. Following this session, Mr. F. de Rose, President of the Council of the European Organization for Nuclear Research, announced the appointment of Mr. J. B. Adams, Director of the PS division to the post of acting Director-General.

  19. 78 FR 40516 - Sunshine Act Meetings

    Science.gov (United States)

    2013-07-05

    ... DISABILITY Sunshine Act Meetings TIME AND DATES: The Members of the National Council on Disability (NCD) will.... MATTERS TO BE CONSIDERED: On Thursday afternoon, the Council will discuss and deliberate a draft NCD... NCD's standing committees. Following these reports, NCD will hear from a panel of policy experts on...

  20. 77 FR 4372 - Sunshine Act Meetings

    Science.gov (United States)

    2012-01-27

    ... DISABILITY Sunshine Act Meetings TIME AND DATES: The Members of the National Council on Disability (NCD) will.... NCD staff will participate in the call from the NCD office at 1331 F Street NW., Suite 850, Washington, DC 20004. Interested parties may join the meeting in person at the NCD office or may join the phone...

  1. 76 FR 53967 - Sunshine Act Meetings

    Science.gov (United States)

    2011-08-30

    ... DISABILITY Sunshine Act Meetings TIME AND DATES: The Members of the National Council on Disability (NCD) will.... NCD staff will participate in the call from the NCD office at 1331 F Street, NW., Suite 850, Washington, DC 20004. Interested parties may join the meeting in person at the NCD office or may join the...

  2. 77 FR 7162 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2012-02-10

    ... HEALTH REVIEW COMMISSION Sunshine Act Meeting Notice February 7, 2012. TIME AND DATE: 10 a.m., Thursday... following in open session: Secretary of Labor v. Mach Mining, LLC, Docket Nos. LAKE 2010-1-R, et al.; and Secretary of Labor v. Mach Mining, LLC, Docket Nos. LAKE 2010-190, et al. (Issues include whether the...

  3. Human Rights Act, 12 February 1987.

    Science.gov (United States)

    1987-01-01

    This document reprints major provisions of the Yukon's (Canada) 1987 Human Rights Act. The Act furthers the public policy that every individual is free and equal in dignity and rights, seeks to discourage and eliminate discrimination, and promotes the underlying principles of Canadian and international human rights instruments. Part 1 contains a Bill of Rights that protects the right to freedom of: 1) religion and conscience, 2) expression, 3) assembly and association, and 4) to enjoyment and disposition of property. Part 2 prohibits discrimination based on ancestry (including color and race), national origin, ethnic or linguistic background or origin, age, sex (including pregnancy), and marital or family status. Discrimination is also prohibited when offering services, goods, or facilities to the public; in connection with employment; in connection with membership in trade unions or trade, occupational, or professional associations; and in negotiation or performance of public contracts. The Bill of Rights lists reasonable causes for discrimination as well as exemptions, including preferential treatment for organization or family members or employment in a private home. Special programs and affirmative action programs are specifically not considered discrimination under this Act. The Act sets forth rules for providing equal pay for work of equal value and creates a Yukon Human Rights Commission to promote human rights and assist adjudication of complaints.

  4. 77 FR 10784 - Sunshine Act Meeting

    Science.gov (United States)

    2012-02-23

    ... CORPORATION Finance, Budget & Program Committee of the Board of Directors; Sunshine Act Meeting DATES: Time..., Washington, DC 20005. Status: Open. CONTACT PERSON FOR MORE INFORMATION: Erica Hall, Assistant Corporate... Report IV. NFMC Interest Income Budget V. Lease Update VI. Corporate Scorecard & Dashboard VII. NFMC...

  5. Women's Educational Equity Act, Third Annual Report.

    Science.gov (United States)

    Follett, Marguerite A., Comp.

    This report contains the following information in regard to the Women's Educational Equity Act: a brief description of the original legislation and the pending legislation; comments on program development; analysis of applications received and funded in the 1978 fiscal year; analysis of three years of funding; identification of products to be…

  6. 78 FR 17403 - No FEAR Act Notice

    Science.gov (United States)

    2013-03-21

    ... basis of race, color, religion, sex, national origin, age, disability, marital status, or political... you believe that you have been the victim of unlawful discrimination on the basis of race, color... provisions of law specified in 5 U.S.C. 2302(d). Dated: March 12, 2013. Edward J. DeMarco, Acting Director...

  7. 75 FR 9601 - Sunshine Act Notices

    Science.gov (United States)

    2010-03-03

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Sunshine Act Notices AGENCY: Federal Election Commission. DATE & TIME: Thursday, March 4, 2010, at 11 a.m.... Audit Hearing: AFL-CIO Cope Political Contributions Committee. DATE & TIME: Thursday, March 4, 2010, at...

  8. 76 FR 64088 - Sunshine Act Notice

    Science.gov (United States)

    2011-10-17

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Sunshine Act Notice AGENCY: Federal Election Commission. DATE AND TIME: Thursday, October 20, 2011 at 10 a.... Proposed Final Audit Report on the Service Employees International Union Committee on Political Education...

  9. 76 FR 53899 - Sunshine Act Notice

    Science.gov (United States)

    2011-08-30

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Sunshine Act Notice AGENCY: Federal Election Commission. DATE AND TIME: Thursday, September 1, 2011 at 10 a... Reporting Purposes. Proposed Final Audit Report on the United Association Political Education Committee (A09...

  10. 77 FR 65687 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2012-10-30

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Sunshine Act Meeting Notice AGENCY: Federal Election Commission. DATE AND TIME: Thursday, November 1, 2012... Future Fund Political Action, McIntosh Draft Advisory Opinion 2012-34: Freedom PAC and Friends of Mike H...

  11. 77 FR 59924 - Sunshine Act Notice

    Science.gov (United States)

    2012-10-01

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Sunshine Act Notice AGENCY: Federal Election Commission. DATE AND TIME: Thursday, October 4, 2012 at 10:00..., 2012 Draft Advisory Opinion 2012-25: American Future Fund, American Future Fund Political Action, Mr...

  12. 75 FR 3466 - Sunshine Act Notices

    Science.gov (United States)

    2010-01-21

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Sunshine Act Notices Agency: Federal Election Commission. Date and Time: Thursday, January 14, 2010, at 10... Political Action by its counsel, Jason Torchinsky. * * * * * Previously Scheduled Date and Time: Thursday...

  13. 77 FR 67816 - Sunshine Act Notice

    Science.gov (United States)

    2012-11-14

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Sunshine Act Notice AGENCY: Federal Election Commission. DATE AND TIME: Thursday, November 15, 2012 at 10... Political Action, McIntosh Draft Advisory Opinion 2012-34: Freedom PAC and Friends of Mike H Audit Division...

  14. 77 FR 33458 - Sunshine Act Meeting

    Science.gov (United States)

    2012-06-06

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Sunshine Act Meeting AGENCY: Federal Election Commission. DATE and TIME: Thursday, June 7, 2012 at 10:00 a... Fund. Audit Division Recommendation Memorandum on The Legacy Committee Political Action Committee (A09...

  15. 78 FR 35032 - Sunshine Act Meetings

    Science.gov (United States)

    2013-06-11

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Sunshine Act Meetings AGENCY: Federal Election Commission. DATE & TIME: Thursday, June 13, 2013 at 10:00 a... Republican Party/V8 (A09-15) Draft Interpretive Rule on Reporting Ultimate Payees of Political Committee...

  16. 76 FR 24489 - Sunshine Act Notice

    Science.gov (United States)

    2011-05-02

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Sunshine Act Notice AGENCY: Federal Election Commission DATE AND TIME: Thursday, May 5, 2011 at 10 a.m... Final Audit Report on the Service Employees International Union. Committee on Political Education (SEIU...

  17. 78 FR 55256 - Sunshine Act Meetings

    Science.gov (United States)

    2013-09-10

    ... From the Federal Register Online via the Government Publishing Office ] FEDERAL ELECTION COMMISSION Sunshine Act Meetings AGENCY: Federal Election Commission. DATE AND TIME: Thursday, September 12... on Political Education; Draft Advisory Opinion 2013-14: Martin Long; OGC Enforcement Manual (To be...

  18. 76 FR 34073 - Sunshine Act Notice

    Science.gov (United States)

    2011-06-10

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Sunshine Act Notice AGENCY: Federal Election Commission. DATE AND TIME: Wednesday, June 15, 2011 at 10 a.m... Political Education Committee (UAPEC) (A09-27). Future Meeting Dates. Management and Administrative Matters...

  19. 77 FR 57087 - Sunshine Act Notice

    Science.gov (United States)

    2012-09-17

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Sunshine Act Notice AGENCY: Federal Election Commission. DATE & TIME: Thursday, September 20, 2012 At 10 a... Draft Advisory Opinion 2012-25: American Future Fund, American Future Fund Political Action, Mr. David...

  20. 77 FR 7162 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2012-02-10

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Sunshine Act Meeting Notice AGENCY: Federal Election Commission. DATE AND TIME: Wednesday, February 15... to the Public. Item To Be Discussed Audit Hearing: National Right to Life Political Action Committee...

  1. 77 FR 26759 - Sunshine Act Meeting

    Science.gov (United States)

    2012-05-07

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Sunshine Act Meeting AGENCY: Federal Election Commission. DATE AND TIME: Thursday, May 10, 2012 at 10:00 a... Political Action Committee (A09-22). Revised Guidebook for Complainants and Respondents on the FEC...

  2. 75 FR 1784 - Sunshine Act Notices

    Science.gov (United States)

    2010-01-13

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Sunshine Act Notices AGENCY: Federal Election Commission. Date and Time: Thursday, January 14, 2010, at 10...: American Future Fund Political Action by its counsel, Jason Torchinsky. Draft Advisory Opinion 2009-29...

  3. Positive outcomes of flexibility and security act

    NARCIS (Netherlands)

    Klein Hesselink, J.

    2009-01-01

    The second evaluation of the Dutch Flexibility and Security Act indicates that in 2006 employers were more inclined to offer employees a new temporary contract after the first one ended, as compared to 2001 when they were unsure about the consequences of the new law and were more likely to offer the

  4. 76 FR 70781 - Sunshine Act Meeting

    Science.gov (United States)

    2011-11-15

    ... will include current capital formation issues for private ] companies and initial public offerings and securities regulation involving smaller public companies. Members of the public may attend the forum without... Sunshine Act, Public Law 94-409, that the Securities and Exchange Commission will host the SEC Government...

  5. 76 FR 41306 - Sunshine Act Meetings; Notice

    Science.gov (United States)

    2011-07-13

    ... & Provision Committee meeting. 1. Promotion & Provision for the Delivery of Legal Services Committee 2..., 2011 Promotion & Provision for the Delivery of Legal Services Committee Agenda 1. Approval of agenda. 2.... David Richardson, Treasurer/Comptroller. 5. Consider and act on revisions to the Consolidated Operating...

  6. An Unselfish Act: Graffiti in Art Education

    Science.gov (United States)

    Eldridge, Laurie A.

    2013-01-01

    Graffiti artist Sentrock sees his graffiti as a selfless act, a way of giving back to the community--when done legally--and inspires a group of middle school students. This is a case study of an artist and educator who teaches about graffiti art in public schools. He is unique in that he delineates between graffiti art and vandalism, and teaches…

  7. 77 FR 56914 - Privacy Act of 1974

    Science.gov (United States)

    2012-09-14

    ... include firewalls, intrusion detection devices, encryption, and other security measures necessary to... AFFAIRS Privacy Act of 1974 AGENCY: Department of Veterans Affairs. ACTION: Notice of new system of... Federal Register a notice of the existence and character of their systems of records. Notice is hereby...

  8. 78 FR 66806 - Privacy Act of 1974

    Science.gov (United States)

    2013-11-06

    ... telecommunication software and hardware. This may include firewalls, intrusion detection devices, encryption, and... AFFAIRS Privacy Act of 1974 AGENCY: Department of Veterans Affairs (VA). ACTION: Notice of a New System of... Federal Register a notice of the existence and character of their systems of records. Notice is hereby...

  9. 78 FR 8538 - Privacy Act of 1974

    Science.gov (United States)

    2013-02-06

    ... intrusion detection system used by HHS and DHS pursuant to the Einstein 2 program. 8. To provide information... a new system of records. SUMMARY: In accordance with the requirements of the Privacy Act of 1974, CMS is establishing a new system of records titled, ``Health Insurance Exchanges (HIX) Program,'' to...

  10. 75 FR 7312 - No FEAR Act Notice

    Science.gov (United States)

    2010-02-18

    ... basis of race, color, religion, sex, national origin, age, disability, or genetic information... Genetic Information Nondiscrimination Act of 2008 (GINA), 42 U.S.C. 2000ff et seq. If you believe that you have been the victim of unlawful discrimination on the basis of race, color, religion, sex, national...

  11. 7 CFR 920.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE KIWIFRUIT GROWN IN CALIFORNIA Definitions... amended by the Agricultural Marketing Agreement Act of 1937, as amended (48 Stat. 31, as amended; 7 U.S.C...

  12. 7 CFR 955.2 - Act.

    Science.gov (United States)

    2010-01-01

    ... the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE VIDALIA ONIONS GROWN IN GEORGIA Definitions... amended by the Agricultural Marketing Agreement Act of 1937, as amended (Sec. 1-19, 48 Stat. 31, as...

  13. 78 FR 30861 - Sunshine Act Meeting

    Science.gov (United States)

    2013-05-23

    ... Business Meeting. DATE AND TIME: Friday, May 31, 2013 at 9:30 a.m. EST. PLACE: Washington Marriott at Metro... Consideration of date change for the September 2013 business meeting IV. Approval of State Advisory Committee...: Lenore Ostrowsky, Acting Chief, Public Affairs Unit (202) 376-8591. Hearing-impaired persons who will...

  14. 77 FR 4645 - Privacy Act Implementation

    Science.gov (United States)

    2012-01-31

    ... toll-free numbers), Federal Housing Finance Agency, 400 Seventh Street, SW., Eighth Floor, Washington... Part 1204 Amendment, Appeals, Correction, Disclosure, Exemptions, Fees, Privacy, Privacy Act, Records... G Street, NW., Washington, DC 20552'' to read as ``400 Seventh Street, SW., Eighth Floor, Washington...

  15. 45 CFR 503.1 - Definitions-Privacy Act.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Definitions-Privacy Act. 503.1 Section 503.1... THE UNITED STATES, DEPARTMENT OF JUSTICE RULES OF PRACTICE PRIVACY ACT AND GOVERNMENT IN THE SUNSHINE REGULATIONS Privacy Act Regulations § 503.1 Definitions—Privacy Act. For the purpose of this part: Agency...

  16. 45 CFR 503.2 - General policies-Privacy Act.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false General policies-Privacy Act. 503.2 Section 503.2... THE UNITED STATES, DEPARTMENT OF JUSTICE RULES OF PRACTICE PRIVACY ACT AND GOVERNMENT IN THE SUNSHINE REGULATIONS Privacy Act Regulations § 503.2 General policies—Privacy Act. The Commission will protect the...

  17. 48 CFR 52.224-2 - Privacy Act.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Privacy Act. 52.224-2... Act. As prescribed in 24.104, insert the following clause in solicitations and contracts, when the... agency function: Privacy Act (APR 1984) (a) The Contractor agrees to— (1) Comply with the Privacy Act of...

  18. 48 CFR 22.403-2 - Copeland Act.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Copeland Act. 22.403-2... Construction 22.403-2 Copeland Act. The Copeland (Anti-Kickback) Act (18 U.S.C. 874 and 40 U.S.C. 3145) makes... person is entitled under a contract of employment. The Copeland Act also requires each contractor and...

  19. The first year of implementation of the Child Justice Act

    African Journals Online (AJOL)

    Is the act working for children: The first year of implementation of the Child Justice Act. ... South African Crime Quarterly ... On 1 April 2011 a year had passed since the implementation of the Child Justice Act. This article interrogates the annual report presented to parliament on the first year of implementation of the Act, and ...

  20. 48 CFR 1552.239-70 - Rehabilitation act notice.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Rehabilitation act notice... Rehabilitation act notice. As prescribed in 1523.7003(a), insert the following clause. Rehabilitation Act Notice (OCT 2000) (a) EPA has a legal obligation under the Rehabilitation Act of 1973, 29 U.S.C. 791, to...