WorldWideScience

Sample records for volumetric infusion pump

  1. [External lumbar drainage with volumetric continuing infusion pump in patients with cerebrospinal fluid leak. A case series].

    Science.gov (United States)

    Manso Melgosa, Ana Belén; García Gutiérrez, Helena; Fernández Porras, Mónica; Castrillo Manero, Ana Berta; Pérez Marijuán, Belén

    To describe the incidence and complications arising in a number of cases of patients with cerebrospinal fluid leak treated by external lumbar drainage with infusion pump (IP) volumetric continuous from 2001 to 2014. Quantify cerebrospinal fluid leak closed by lumbar drainage with IP. Retrospective descriptive case series study. patients undergoing transsphenoidal pituitary surgery, Chiari surgery and laminectomy, that developed postoperative cerebrospinal fluid leak treated with continuous external lumbar drainage by IP. age, sex, type of intervention, variables related to the practice of the pump and complications. Average and medians were calculated for quantitative variables, frequencies and percentages for qualitative. Sample: 11 subjects. Incidence in running IP: disconnection, occlusion and acoustic alarm activation. Most frequently complication is headache; a case of pneumocephalus. The small number of subjects and the heterogeneity of these do not allow for comparison or establishing associations between variables. The resolution of the cerebrospinal fluid leak with continuous IP is lower in this study than others, and may be influenced by the small number of subjects. It should be noted the frequent activation of the pump alarm for no apparent cause. Protocol would be developed for preparing the IP team to reduce the acoustic alarm activation, and would make a prospective multicenter study. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

  2. Understanding Infusion Pumps.

    Science.gov (United States)

    Mandel, Jeff E

    2017-08-30

    Infusion systems are complicated electromechanical systems that are used to deliver anesthetic drugs with moderate precision. Four types of systems are described-gravity feed, in-line piston, peristaltic, and syringe. These systems are subject to a number of failure modes-occlusion, disconnection, siphoning, infiltration, and air bubbles. The relative advantages of the various systems and some of the monitoring capabilities are discussed. A brief example of the use of an infusion system during anesthetic induction is presented. With understanding of the functioning of these systems, users may develop greater comfort.

  3. Patient-controlled analgesic infusion pumps.

    Science.gov (United States)

    2001-05-01

    Patient-controlled analgesic (PCA) infusion devices allow patients to self-administer narcotic analgesics within the limits prescribed by the physician. PCA therapy is typically used for postoperative, obstetric, terminally ill, and trauma patients. PCA pumps deliver solutions intravenously, subcutaneously, or epidurally and allow patient activation by means of a pendant button on a cord connected to the pump or a button directly on the pump. We evaluated nine PCA pumps from six suppliers. Three of these pumps are syringe-type, while the others use cassette-based fluid delivery. Because PCA pumps have often been cited as examples of devices that contribute to medical error (the most significant risk connected with PCA infusion is overmedication), the accident resistance of each device weighed heavily in our testing. The pumps we tested exhibit varying levels of performance, resistance to accidents and tampering, and ease of use. We rate six of them Acceptable. While none of the six units stands out as ideal, they meet most of our criteria, and we consider them somewhat better choices than the rest. We rate one other pump Acceptable (with Conditions) because, in one of its operating modes, it has a drawback that could be dangerous to patients; we consider its use acceptable only if the hospital doesn't employ the operating mode in question. Finally, we rate two pumps Not Recommended because they both have a significant number of disadvantages.

  4. 75 FR 21641 - Infusion Pumps; Public Meeting; Request for Comments

    Science.gov (United States)

    2010-04-26

    ... HUMAN SERVICES Food and Drug Administration Infusion Pumps; Public Meeting; Request for Comments AGENCY... Food and Drug Administration (FDA) is announcing a public meeting regarding external infusion pumps... infusion pump use, to help the agency identify quality assurance strategies to mitigate these problems,...

  5. [Radiotherapy and implantable medical device: example of infusion pumps].

    Science.gov (United States)

    Abrous-Anane, S; Benhassine, S; Lopez, S; Cristina, K; Mazeron, J-J

    2013-12-01

    Indication for radiotherapy is often questioned for patients equipped with implantable medical devices like infusion pumps as the radiation tolerance is poor or not known. We report here on the case of a patient who we treated with pelvic radiotherapy for cervical cancer and who had an infusion pump in iliac fossa. We conducted a series of tests on five identical pumps that insured that the treatment protocol is harmless to the implanted device.

  6. Smart syringe pumps for drug infusion during dental intravenous sedation.

    Science.gov (United States)

    Seo, Kwang-Suk; Lee, Kiyoung

    2016-09-01

    Dentists often sedate patients in order to reduce their dental phobia and stress during dental treatment. Sedatives are administered through various routes such as oral, inhalation, and intravenous routes. Intravenous administration has the advantage of rapid onset of action, predictable duration of action, and easy titration. Typically, midazolam, propofol or dexmedetomidine are used as intravenous sedatives. Administration of these sedatives via infusion by using a syringe pump is more effective and successful than infusing them as a bolus. However, during intravenous infusion of sedatives or opioids using a syringe pump, fatal accidents may occur due to the clinician's carelessness. To prevent such risks, smart syringe pumps have been introduced clinically. They allow clinicians to perform effective sedation by using a computer to control the dose of the drug being infused. To ensure patient safety, various alarm features along with a drug library, which provides drug information and prevents excessive infusion by limiting the dose, have been added to smart pumps. In addition, programmed infusion systems and target-controlled infusion systems have also been developed to enable effective administration of sedatives. Patient-controlled infusion, which allows a patient to control his/her level of sedation through self-infusion, has also been developed. Safer and more successful sedation may be achieved by fully utilizing these new features of the smart pump.

  7. Quantitative assessment of haemolysis secondary to modern infusion pumps.

    Science.gov (United States)

    Poder, T G; Boileau, J-C; Lafrenière, R; Thibault, L; Carrier, N; de Grandmont, M-J; Beauregard, P

    2017-04-01

    Although most studies have shown that little haemolysis is induced by infusion pumps, there are some notable exceptions. Only limited data are available on the actual infusion pumps that are most used in hospitals in Quebec and elsewhere, namely, the Infusomat(®) Space (peristaltic), Plum A+™ (piston) and Colleague(®) CXE (shuttle) pumps. Haemolysis and potassium levels were compared before and after the use of the three different infusion pumps. Using 135 units of packed red blood cells (RBCs) aged from 10 to 28 days, 27 measurements were taken for each pump at various flow rates (30, 60, 150, 300 and 450 ml/h) and were compared with measurements taken before using the pumps. The range of flow rates was chosen to cover those of paediatric and adult transfusions. The shuttle- and piston-type pumps resulted in low haemolysis levels. The peristaltic-type pump produced significantly more haemolysis, which worsened at low flow rates, but the absolute value of haemolysis remained within the range recommended by the regulatory agencies in North America and Europe. Approximately two-thirds of the haemolysis produced by the peristaltic-type pump seemed to be secondary to the use of an antisiphon valve (ASV) on the transfusion line recommended by the manufacturer. Potassium levels did not increase with the use of the pumps. Modern infusion pumps widely used in hospitals in Quebec and elsewhere produce non-threatening levels of haemolysis during the transfusion of packed RBCs aged from 10 to 28 days. ASVs appear to induce additional haemolysis, and we do not recommend using them for blood transfusion. © 2017 International Society of Blood Transfusion.

  8. Platelet transfusion in chemotherapy patients: comparison of the effect of intravenous infusion pumps versus gravity transfusion.

    Science.gov (United States)

    Meess, A

    2015-01-01

    Platelet concentrates are given to patients suffering with severe thrombocytopenia usually by a gravity transfusion procedure. Increasing patient numbers that are in need of this treatment increase the pressure on hospital staff and space. In order to combat time issues, the use of medical devices such as intravenous infusion pumps are thought to be beneficial for time and simultaneously for safety in transfusion practices. By using infusion pumps, platelet concentrates can be transfused in less time and provide accurate volume measurements. Manufacturers of infusion pumps claim that these devices are safe to be used for blood products including platelet concentrates. However, published studies were performed on older models and newer devices are on the market now. The purpose of this study is to evaluate infusion pumps, which are claimed to be suitable for blood products and to investigate the impact the pumps had on platelets. Furthermore, the study revealed if the intravenous infusion pumps are safe to be used for platelet transfusion as claimed by manufacturers. A simulated transfusion was performed using the Carefusion Alaris GP Plus volumetric pump and Fresenius Kabi Volumat Agilia infusion pump. Samples were taken from expired platelet concentrates before and after passage through the pump. All samples were investigated for full blood count that included platelet count, mean platelet volume (MPV), platelet distribution width (PDW) and a plateletcrit (PCT). The samples were then centrifuged to achieve platelet-poor plasma and then tested for lactate dehydrogenase (LDH). A power calculation performed on the statistical power analysis program G*power indicated a requirement of 82 samples for a power of 80%. Statistical analysis was performed with the IBM SPSS statistic software. A paired sample t-test was used to calculate mean, standard deviation and P values for the infusion pumps used. The Wilcoxon Signed Rank Test was used to evaluate results that had a non

  9. Infusion of iloprost without a peristaltic pump: Safety and tolerability

    Directory of Open Access Journals (Sweden)

    Paola Faggioli

    2013-04-01

    Full Text Available Introduction: Iloprost is a potent prostacyclin (PGI2 analogue that is effective in the treatment of peripheral arterial disease, vasculitis, pulmonary hypertension, and secondary Raynaud’s phenomenon. Intravenous infusions are generally administered with the aid of a peristaltic pump to reduce the risk of adverse reactions caused by unintentional increases in the infusion rate. This increases the cost of care in terms of equipment and personnel and may limit the use of this drug. Materials and methods: We retrospectively analyzed 18,432 iloprost infusions administered between 1999 and 2009 to 272 patients with systemic sclerosis (n = 253 and 19 with peripheral arterial disease (n = 19. All infusions were administered in the day hospital over 6 h with a normal IV set-up with a roller flow regulator. Flow rates were set to deliver iloprost at 1-2 ng/kg/min. Rates were verified by direct drop counts during the first 15-20 minutes of the infusion and at each subsequent check. Results: There were no adverse events that were fatal, life-threatening, or associated with prolongation of hospitalization and very few events requiring intensive care or continuous monitoring. The latter included 4 cases of tachycardia/arrhythmia (extrasystoles in most cases, 3 cases of hypotension (systolic pressure < 80 mmHg, and 2 cases of hypertension (BP > 170/100 mmHg. All other adverse reactions were mild, reversible, and similar to those seen with iloprost infusion with peristaltic pump. Only one patient had to be switched to another prostanoid (due to intolerance. Discussion: Iloprost infusion administered with a normal IV flow regulator appears to be as safe, well tolerated, and effective as traditional infusion with a peristaltic pump.

  10. A Hazard Analysis for a Generic Insulin Infusion Pump

    Science.gov (United States)

    Zhang, Yi; Jones, Paul L.; Jetley, Raoul

    2010-01-01

    Background Researchers at the Food and Drug Administration (FDA)/Center for Device and Radiological Health/Office of Science and Engineering Laboratories have been exploring the concept of model-based engineering as a means for improving the quality of medical device software. Insulin pumps were chosen as a research subject because their design provides the desired degree of research complexity and these types of devices present an ongoing regulatory challenge. Methods Insulin pump hazards and their contributing factors are considered in the context of a highly abstract generic insulin infusion pump (GIIP) model. Hazards were identified by consulting with manufacturers, pump users, and clinicians; by reviewing national and international standards and adverse event reports collected by the FDA; and from workshops sponsored by Diabetes Technology Society. This information has been consolidated in tabular form to facilitate further community analysis and discussion. Results A generic insulin infusion pump model architecture has been established. A fairly comprehensive hazard analysis document, corresponding to the GIIP model, is presented in this article. Conclusions We believe that this work represents the genesis of an insulin pump safety reference standard upon which future insulin pump designs can be based to help ensure a basic level of safety. More interaction with the diabetes community is needed to assure the quality of this safety modeling process. PMID:20307387

  11. Home Healthcare Medical Devices: Infusion Therapy - Getting the Most Out of Your Pump

    Science.gov (United States)

    ... Home Healthcare Medical Devices: Infusion Therapy - Getting the Most Out of Your Pump Share Tweet Linkedin Pin ... and accessories schedule routine maintenance What are the most common problems with an infusion pump and how ...

  12. Developing a System for Integraded Automatic Control of Mutiple Infusion Pumps : The Multiplex infusion system

    NARCIS (Netherlands)

    Doesburg, Frank

    2013-01-01

    Most errors in ICUs are related to intravenous (IV) therapy. Previous studies suggested that hard to operate infusion pumps and the high cognitive workload for ICU nurses contribute to these errors. Conventional IV therapy requires separate lumens for incompatible IV drugs. This often requires the p

  13. Comparative analytics of infusion pump data across multiple hospital systems.

    Science.gov (United States)

    Catlin, Ann Christine; Malloy, William X; Arthur, Karen J; Gaston, Cindy; Young, James; Fernando, Sudheera; Fernando, Ruchith

    2015-02-15

    A Web-based analytics system for conducting inhouse evaluations and cross-facility comparisons of alert data generated by smart infusion pumps is described. The Infusion Pump Informatics (IPI) project, a collaborative effort led by research scientists at Purdue University, was launched in 2009 to provide advanced analytics and tools for workflow analyses to assist hospitals in determining the significance of smart-pump alerts and reducing nuisance alerts. The IPI system allows facility-specific analyses of alert patterns and trends, as well as cross-facility comparisons of alert data uploaded by more than 55 participating institutions using different types of smart pumps. Tools accessible through the IPI portal include (1) charts displaying aggregated or breakout data on the top drugs associated with alerts, numbers of alerts per device or care area, and override-to-alert ratios, (2) investigative reports that can be used to characterize and analyze pump-programming errors in a variety of ways (e.g., by drug, by infusion type, by time of day), and (3) "drill-down" workflow analytics enabling users to evaluate alert patterns—both internally and in relation to patterns at other hospitals—in a quick and efficient stepwise fashion. The formation of the IPI analytics system to support a community of hospitals has been successful in providing sophisticated tools for member facilities to review, investigate, and efficiently analyze smart-pump alert data, not only within a member facility but also across other member facilities, to further enhance smart pump drug library design. Copyright © 2015 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

  14. A Review of the Security of Insulin Pump Infusion Systems

    Science.gov (United States)

    Paul, Nathanael; Kohno, Tadayoshi; Klonoff, David C

    2011-01-01

    Insulin therapy has enabled patients with diabetes to maintain blood glucose control to lead healthier lives. Today, rather than injecting insulin manually using syringes, a patient can use a device such as an insulin pump to deliver insulin programmatically. This allows for more granular insulin delivery while attaining blood glucose control. Insulin pump system features have increasingly benefited patients, but the complexity of the resulting system has grown in parallel. As a result, security breaches that can negatively affect patient health are now possible. Rather than focus on the security of a single device, we concentrate on protecting the security of the entire system. In this article, we describe the security issues as they pertain to an insulin pump system that includes an embedded system of components, which include the insulin pump, continuous glucose management system, blood glucose monitor, and other associated devices (e.g., a mobile phone or personal computer). We detail not only the growing wireless communication threat in each system component, but also describe additional threats to the system (e.g., availability and integrity). Our goal is to help create a trustworthy infusion pump system that will ultimately strengthen pump safety, and we describe mitigating solutions to address identified security issues. PMID:22226278

  15. A Review of the Security of Insulin Pump Infusion Systems

    Energy Technology Data Exchange (ETDEWEB)

    Klonoff, David C. [Mills-Peninsula Health Services; Paul, Nathanael R [ORNL; Kohno, Tadayoshi [University of Washington, Seattle

    2011-01-01

    Insulin therapy has enabled diabetic patients to maintain blood glucose control to lead healthier lives. Today, rather than manually injecting insulin using syringes, a patient can use a device, such as an insulin pump, to programmatically deliver insulin. This allows for more granular insulin delivery while attaining blood glucose control. The insulin pump system features have increasingly benefited patients, but the complexity of the resulting system has grown in parallel. As a result security breaches that can negatively affect patient health are now possible. Rather than focus on the security of a single device, we concentrate on protecting the security of the entire system. In this paper we describe the security issues as they pertain to an insulin pump system that includes an embedded system of components including the insulin pump, continuous glucose management system, blood glucose monitor, and other associated devices (e.g., a mobile phone or personal computer). We detail not only the growing wireless communication threat in each system component, but we also describe additional threats to the system (e.g., availability and integrity). Our goal is to help create a trustworthy infusion pump system that will ultimately strengthen pump safety, and we describe mitigating solutions to address identified security issues both for now and in the future.

  16. Haemolysis following rapid experimental red blood cell transfusion--an evaluation of two infusion pumps

    DEFF Research Database (Denmark)

    Hansen, Tom Giedsing; Sprogøe-Jakobsen, U; Pedersen, C M;

    1998-01-01

    The vast majority of infusion pumps used for rapid transfusion of large amounts of blood have never been properly examined regarding their influence on the quality of the red blood cells (RBCs) infused. In this study, we evaluated the effect of two different infusion pumps on the degree of RBC...

  17. Haemolysis following rapid experimental red blood cell transfusion--an evaluation of two infusion pumps

    DEFF Research Database (Denmark)

    Hansen, Tom Giedsing; Sprogøe-Jakobsen, U; Pedersen, C M

    1998-01-01

    The vast majority of infusion pumps used for rapid transfusion of large amounts of blood have never been properly examined regarding their influence on the quality of the red blood cells (RBCs) infused. In this study, we evaluated the effect of two different infusion pumps on the degree of RBC de...

  18. User preference for a portable syringe pump for iloprost infusion

    Directory of Open Access Journals (Sweden)

    Laria A

    2015-05-01

    Full Text Available Antonella Laria,1 Alfredo Maria Lurati,1 Katia Angela Re,1 Maria Grazia Marrazza,1 Daniela Mazzocchi,1 Alberto Farina,2 Magda Scarpellini,1 1Department of Rheumatology, Fornaroli Hospital, Magenta, Milan, Italy; 2Medical Affairs Department, Italfarmaco S.p.A., Cinisello Balsamo, Milan, Italy Purpose: Administration of intravenous iloprost – a first-line European League Against Rheumatism (EULAR-recommended choice for the treatment of scleroderma (SSc-related digital vasculopathy – requires repeated treatment cycles of 6 hours per day in a hospital setting. During the infusion, patient mobility is considerably restricted due to the size and fixity of traditional syringe pumps. The aim of this study was to evaluate the satisfaction level of patients and nurses, after the introduction of a new portable syringe pump (Infonde®, Italfarmaco S.p.A., Milan, Italy at the Department of Rheumatology, Magenta Hospital, Milan, Italy. Patients and methods: Thirty-four consecutive SSc patients receiving stable therapy with iloprost, previously administered with a fixed pump, were treated using the portable Infonde® pump. Patients (n=34 and nurses (n=4 were asked to answer a nine- and six-item questionnaire, respectively, to assess the satisfaction of the administration comparing the new device versus the previous one. The health care staff of the ward developed the questionnaire, and the response scores ranged from 0 (fixed device better to 10 (portable device better; thus a score >5 indicates a preference for Infonde®. Results: Patients' answers indicated a preference towards the new portable syringe pump, versus the previous fixed pump. Questionnaires administered to patients generated a total of 306 responses, with over 95% of the responses in the range 8–10, of which 89% had a score equal to 10. The responses of nurses showed a score equal to 10 in 100% cases. No significant adverse events were recorded, indicating no change in the tolerability

  19. Determination of 24-hour insulin infusion pattern by an artificial endocrine pancreas for intravenous insulin infusion with a miniature pump

    DEFF Research Database (Denmark)

    Kølendorf, K; Christiansen, J S; Bojsen, J;

    1981-01-01

    UNLABELLED: Intravenous insulin infusion with a glucose controlled insulin infusion system (GCIIS) is known to restore glucose homeostasis. A simpler approach to improve blood glucose regulation is preprogrammed intravenous insulin infusion with portable pumps without sensor-mediated feedback. We...... report a study designed to evaluate whether the preprogrammed insulin infusion pattern to be used in the miniature insulin infusion pump (MIIP) could be optimized by concomitant employment of the GCIIS for blood glucose control. Six juvenile-onset insulin-dependent diabetics (mean age 31 yrs) were...... studied. Mean blood glucose (MBG) was 6.2 mmol/l +/- 0.5 (SD) during glucose controlled infusion and 5.3 +/- 0.6 during the combined MIIP + GCIIS-day. The insulin requirements calculated from the s.c. regimen (56 U +/- 10 SD) were identical to the GCIIS-measured (51 U +/- 14) and to the amounts delivered...

  20. Assessment of implantable infusion pumps for continuous infusion of human insulin in rats: potential for group housing

    DEFF Research Database (Denmark)

    Jensen, Vivi Flou Hjorth; Molck, Anne-Marie; Martensson, Martin

    2017-01-01

    compound in these studies, and a comparator model of persistent exposure by HI infusion from external pumps has recently been developed to support toxicological evaluation of long-acting insulin analogues. However, this model requires single housing of the animals. Developing an insulin-infusion model......Group housing is considered to be important for rats, which are highly sociable animals. Single housing may impact behaviour and levels of circulating stress hormones. Rats are typically used in the toxicological evaluation of insulin analogues. Human insulin (HI) is frequently used as a reference...... which allows group housing would therefore greatly improve animal welfare. The aim of the present study was to investigate the suitability of implantable infusion pumps for HI infusion in group-housed rats. Group housing of rats implanted with a battery-driven pump proved to be possible. Intravenous...

  1. Mathematical Model Defining Volumetric Losses of Hydraulic Oil Compression in a Variable Capacity Displacement Pump

    Directory of Open Access Journals (Sweden)

    Paszota Zygmunt

    2015-01-01

    Full Text Available The objective of the work is to develop the capability of evaluating the volumetric losses of hydraulic oil compression in the working chambers of high pressure variable capacity displacement pump. Volumetric losses of oil compression must be determined as functions of the same parameters, which the volumetric losses due to leakage, resulting from the quality of design solution of the pump, are evaluated as dependent on and also as function of the oil aeration coefficient Ɛ. A mathematical model has been developed describing the hydraulic oil compressibility coefficient klc|Δppi;Ɛ;v as a relation to the ratio ΔpPi/pn of indicated increase ΔpPi of pressure in the working chambers and the nominal pressure pn, to the pump capacity coefficient bP, to the oil aeration coefficient  and to the ratio v/vnof oil viscosity v and reference viscosity vn. A mathematical model is presented of volumetric losses qpvc|ΔpPi;bp;;vof hydraulic oil compression in the pump working chambers in the form allowing to use it in the model of power of losses and energy efficiency

  2. Graphical user interface simplifies infusion pump programming and enhances the ability to detect pump-related faults.

    Science.gov (United States)

    Syroid, Noah; Liu, David; Albert, Robert; Agutter, James; Egan, Talmage D; Pace, Nathan L; Johnson, Ken B; Dowdle, Michael R; Pulsipher, Daniel; Westenskow, Dwayne R

    2012-11-01

    Drug administration errors are frequent and are often associated with the misuse of IV infusion pumps. One source of these errors may be the infusion pump's user interface. We used failure modes-and-effects analyses to identify programming errors and to guide the design of a new syringe pump user interface. We designed the new user interface to clearly show the pump's operating state simultaneously in more than 1 monitoring location. We evaluated anesthesia residents in laboratory and simulated environments on programming accuracy and error detection between the new user interface and the user interface of a commercially available infusion pump. With the new user interface, we observed the number of programming errors reduced by 81%, the number of keystrokes per task reduced from 9.2 ± 5.0 to 7.5 ± 5.5 (mean ± SD), the time required per task reduced from 18.1 ± 14.1 seconds to 10.9 ± 9.5 seconds and significantly less perceived workload. Residents detected 38 of 70 (54%) of the events with the new user interface and 37 of 70 (53%) with the existing user interface, despite no experience with the new user interface and extensive experience with the existing interface. The number of programming errors and workload were reduced partly because it took less time and fewer keystrokes to program the pump when using the new user interface. Despite minimal training, residents quickly identified preexisting infusion pump problems with the new user interface. Intuitive and easy-to-program infusion pump interfaces may reduce drug administration errors and infusion pump-related adverse events.

  3. Clinical safety of magnetic resonance imaging in patients with implanted SynchroMed EL infusion pumps

    Energy Technology Data Exchange (ETDEWEB)

    Diehn, Felix E.; Wood, Christopher P.; Watson, Robert E.; Hunt, Christopher H. [Mayo Clinic, Department of Radiology, Rochester, MN (United States); Mauck, William D. [Mayo Clinic, Department of Anesthesiology, Rochester, MN (United States); Burke, Michelle M. [Mayo Clinic, Department of Psychiatry and Psychology, Rochester, MN (United States)

    2011-02-15

    Patients with implanted SynchroMed spinal infusion pumps (Medtronic, Inc., Minneapolis, MN) routinely undergo magnetic resonance imaging at our institution. In August 2008, Medtronic issued an urgent medical device correction report regarding several pumps. Because of the rare potential ''for a delay in the return of proper drug infusion'' and ''for a delay in the logging of motor stall events,'' ''a patient's pump must be interrogated after MRI exposure in order to confirm proper pump functionality.'' This is particularly important in patients receiving intrathecal baclofen, for whom a delay in return of proper pump infusion could lead to life-threatening baclofen withdrawal syndrome. The objective of this report is to present our experience and protocol of performing magnetic resonance imaging in patients with implanted SynchroMed EL pumps. We retrospectively reviewed records of 86 patients with implanted SynchroMed EL spinal infusion pumps who underwent 112 examinations on 1.5-T magnetic resonance imaging scanners from September 1, 1998 to July 7, 2004. No SynchroMed EL pumps were damaged by magnetic resonance imaging, and the programmable settings remained unchanged in all patients. Our data suggest that SynchroMed EL pump malfunction is indeed rare after routine clinical 1.5-T magnetic resonance imaging examinations. However, based on the Medtronic correction report, we perform pump interrogation before and after imaging. (orig.)

  4. Review of epinephrine solution use in 400 consecutive cases of burn reconstruction. Are infusion pumps safe?

    Science.gov (United States)

    Maguiña, Pirko; Velez, Mario

    2013-01-01

    Infiltration of diluted epinephrine solutions is often used in reconstructive surgery to produce local vasoconstriction and minimize bleeding. A total of 400 burn reconstruction procedures were performed with the aid of epinephrine solution between July 2008 and July 2011. We used to consider this practice very safe, but after encountering several complications, we decided to perform a retrospective review to look at all complications in detail and identify opportunities to improve safety. We encountered nine complications including one case of flash pulmonary edema and one patient with acute carpal tunnel syndrome. All severe complications were seen when the epinephrine solution was infiltrated with the aid of an electric infusion pump. Infusion pumps do not allow for reliable control of the amount of infiltration of epinephrine solutions. We conclude that infusion pumps may unnecessarily increase the risk for complications. This has resulted in a change in our practice. We now use infusion pumps only in selected cases.

  5. [Incorrect programming of a target controlled infusion pump. Case SENSAR of the trimester].

    Science.gov (United States)

    2014-10-01

    We report the case of a patient who underwent surgical aortic valve replacement. During general anaesthesia maintenance, the patient received a remifentanyl infusion via a target controlled infusion (TCI) system. The infusion pump that was prepared to deliver the infusion showed malfunction at the beginning of the surgery, so it was quickly replaced with a second pump. After a few minutes into the surgery, the patient presented with hypotension refractory to treatment. The remifentanyl syringe also emptied faster than expected. On reviewing the TCI pump, it was found that it was erroneously programmed for propofol instead of remifentanyl, thus the patient had received a very high dose of remifentanyl that was probably the cause of the haemodynamic disturbances. The incident was an error in equipment use, facilitated by hurry, lack of checking of the equipment prior to its use, and the complex and unclear design of the devices' screens. After analysis of this incident, all TCI pumps were reviewed, and all the programs for infrequently used drugs were deleted. Furthermore, 2 pumps were selected for exclusive use in the cardiac surgery theatre, one with propofol-only programming, and the other with remifentanyl-only programming, both clearly marked and situated in fixed places in that theatre. Copyright © 2014 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España. All rights reserved.

  6. User experience network. Erroneous downstream occlusion alarms may disable Smiths Medical CADD-Solis infusion pumps.

    Science.gov (United States)

    2010-10-01

    Due to an issue in manufacturing, downstream occlusion (DSO) sensors in some Smiths Medical CADD-Solis infusion pumps may drift out of calibration, potentially resulting in erroneous alarms that disable the units. Hospitals experiencing the problem should return affected units to Smiths Medical for recalibration (free of charge) and should consider testing all their CADD-Solis pumps during routine maintenance to ensure that they alarm appropriately for downstream occlusions.

  7. In vitro viability effects on apheresis and buffy-coat derived platelets administered through infusion pumps

    Directory of Open Access Journals (Sweden)

    Sandgren P

    2014-12-01

    Full Text Available Per Sandgren,1,2 Veronica Berggren,3 Carl Westling,1,2 Viveka Stiller1 1Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, 2Department of Laboratory Medicine, Karolinska Institutet, 3Department of Neonatology, Karolinska University Hospital, Stockholm, SwedenBackground: Different infusion pump systems as well as gravity infusion have been widely used in neonatal transfusion. However, the limited number of published studies describing the use of infusion pumps on platelets illustrates the necessity for more robust data.Methods: To evaluate the potential in vitro effects on the cellular, metabolic, functional and phenotypic properties of platelets, we set up a four-arm paired study simultaneously comparing the use of different infusion pumps (Alaris® CC/GP with unexposed platelets. The platelet units (n=8 were either produced by the apheresis technique and suspended in 100% plasma or derived from buffy coats to yield platelet units stored in approximately 30% plasma and 70% SSP+. Fresh and 5-day old platelets were tested.Results: Regardless of the production system or storage time used, no significant differences were observed in glucose and lactate concentration, pH, adenosine triphosphate levels, response to extent of shape change, hypotonic shock response reactivity, and CD62P expression. Similarly, no differences were observed in expression of the conformational epitope on glycoprotein IIb/IIIa, determined using procaspase-activating compound 1, or in the expression of CD42b and platelet-endothelial cell adhesion molecule-1 in a comparison between platelets administered through infusion pumps versus unexposed platelets.Conclusion: Using Alaris CC/GP infusion pumps had no influence on the cellular, functional, and phenotypic in vitro properties of platelets. This fact seems not to be affected by different production systems or storage time.Keywords: platelets, neonatal platelet transfusion

  8. Effect of the working liquid compressibility on the picture of volumetric and mechanical losses in a high pressure displacement pump used in a hydrostatic drive

    National Research Council Canada - National Science Library

    Paszota, Zygmunt

    2012-01-01

    Working liquid compressibility may considerably change the values and proportions of coefficients of volumetric and mechanical energy losses in the displacement pump used in a hydrostatic drive system...

  9. Security risk of medical devices in IT networks: the case of an infusion and infusion syringe pump

    Science.gov (United States)

    Knackmuß, Jenny; Möller, Thomas; Pommerien, Wilfried; Creutzburg, Reiner

    2015-03-01

    Nowadays, wearable and implantable medical devices are being increasingly deployed to improve diagnosis, monitoring, and therapy for various medical conditions. Compared to other types of electronics and computing systems, security attacks on these medical devices have extreme consequences and must be carefully analyzed and prevented with strongest efforts. Often, the security vulnerabilities of such systems are not well understood or underestimated. The aim of this paper is to demonstrate security attacks that can easily be done in the laboratory on a popular infusion pump on the market, and also propose defenses against such attacks.

  10. Iloprost infusion by a new device as a portable syringe pump: safety, tolerability and agreement

    Directory of Open Access Journals (Sweden)

    Paola Faggioli

    2012-12-01

    Full Text Available Background Iloprost, prostacyclin (PGI2 analogue, effective in treatment of peripheral arterial disease, secondary Raynaud's phenomenon (RP to connective tissue disease (CTD, vasculitis, pulmonary hypertension, is usually infused through peristaltic pump, or recently through a flow regulator.Materials and methods We tested a new portable syringe pump (Pompa Infonde®, Italfarmaco S.p.A., Cinisello Balsamo, Milano on 120 patients affected by RP to CTD and cryoglobulinaemia, in iloprost therapy with a flow regulator.Results Iloprost infused through portable syringe pump is better tolerated, better appreciated by the patients and nurses and no difference was observed on therapeutic effects, with a lower incidence of side effects statistically significant. Only 3 patients were unable to tolerate the device (2 for changes in pressure and 1 for fear and shifted to traditional method of iloprost infusion.Conclusions Iloprost infusion through the portable syringe Pompa Infonde® appears to be safe, better tolerated, more acceptable and equally effective compared to infusion through a flow regulator.

  11. Impact of Computerized Order Entry to Pharmacy Interface on Order-Infusion Pump Discrepancies

    Directory of Open Access Journals (Sweden)

    Rebecca A. Russell

    2015-01-01

    Full Text Available Background. The ability of safety technologies to decrease errors, harm, and risk to patients has yet to be demonstrated consistently. Objective. To compare discrepancies between medication and intravenous fluid (IVF orders and bedside infusion pump settings within a pediatric intensive care unit (PICU before and after implementation of an interface between computerized physician order entry (CPOE and pharmacy systems. Methods. Within a 72-bed PICU, medication and IVF orders in the CPOE system and bedside infusion pump settings were collected. Rates of discrepancy were calculated and categorized by type. Results were compared to a study conducted prior to interface implementation. Expansion of PICU also occurred between study periods. Results. Of 455 observations, discrepancy rate decreased for IVF (p=0.01 compared to previous study. Overall discrepancy rate for medications was unchanged; however, medications infusing without an order decreased (p<0.01, and orders without corresponding infusion increased (p<0.05. Conclusions. Following implementation of an interface between CPOE and pharmacy systems, fewer discrepancies between IVF orders and infusion pump settings were observed. Discrepancies for medications did not change, and some types of discrepancies increased. In addition to interface implementation, changes in healthcare delivery and workflow related to ICU expansion contributed to observed changes.

  12. Surgical aspects and complications of continuous intraperitoneal insulin infusion with an implantable pump

    NARCIS (Netherlands)

    Haveman, Jan Willem; Logtenberg, Susan J. J.; Kleefstra, Nanne; Groenier, Klaas H.; Bilo, Henk J. G.; Blomme, Adri M.

    2010-01-01

    Continuous intraperitoneal insulin infusion (CIPII) with an implantable pump is safe and effective in selected subjects with diabetes. Our aim was to assess surgical experience and complications with CIPII. We performed a retrospective longitudinal observational cohort study of patients that started

  13. Surgical aspects and complications of continuous intraperitoneal insulin infusion with an implantable pump

    NARCIS (Netherlands)

    Haveman, Jan Willem; Logtenberg, Susan J. J.; Kleefstra, Nanne; Groenier, Klaas H.; Bilo, Henk J. G.; Blomme, Adri M.

    Continuous intraperitoneal insulin infusion (CIPII) with an implantable pump is safe and effective in selected subjects with diabetes. Our aim was to assess surgical experience and complications with CIPII. We performed a retrospective longitudinal observational cohort study of patients that started

  14. Drug Delivery: Enabling Technology for Drug Discovery and Development. iPRECIO® Micro Infusion Pump: Programmable, Refillable, and Implantable

    OpenAIRE

    Tan, Tsung; Watts, Stephanie W.; Davis, Robert Patrick

    2011-01-01

    Successful drug delivery using implantable pumps may be found in over 12,500 published articles. Their versatility in delivering continuous infusion, intermittent or complex infusion protocols acutely or chronically has made them ubiquitous in drug discovery and basic research. The recent availability of iPRECIO®, a programmable, refillable, and implantable infusion pump has made it possible to carry out quantitative pharmacology (PKPD) in single animals. When combined with specialized cathet...

  15. [Initial research of one-beam pumping up-conversion 3D volumetric display based on Er:ZBLAN glass].

    Science.gov (United States)

    Chen, Xiao-bo; Li, Mei-xian; Wen, Ou; Zhang, Fu-chu; Song, Zeng-fu

    2003-06-01

    This paper investigates one-beam pumping up-conversion three-dimensional volumetric display, which is based on a Er:ZBLAN fluoride glass. The light-length of the facula of one-beam up-conversion luminescence was studied by a 966 nm semiconductor laser. The up-conversion luminescence spectrum was also obtained. It was found that the property of one-beam pumping three-dimensional volumetric display can be improved significantly by 1.52 microns LD laser multi-photon up-conversion, this finding has not been reported.

  16. Implementing smart pumps for epidural infusions in an academic medical center.

    Science.gov (United States)

    Kennerly, Julie; Jenkins, Alex; Lewis, Ashley N; Eckel, Stephen F

    2012-04-01

    A hospital's initial experience with the implementation of new smart-pump technology for epidural drug delivery is described, with a discussion of challenges and lessons learned during the implementation process. After a focused review of epidural medication use and prescribing patterns at the University of North Carolina Hospitals and Clinics (UNCH), a multidisciplinary team guided the selection of new smart pumps and the development of associated software tools. The new devices were programmed to display a "master drug library" of recommended drug concentrations, doses, and rates, which were consistent with newly created order sets intended to standardize prescriber ordering and nurse administration intended to help standardize prescriber ordering and nurse administration of adult and pediatric epidural infusions. However, data retrieved from the new units after several months of use indicated that nurses were still programming about 60% of epidural smart-pump infusions without using the onboard drug library (in effect circumventing the units' patient-safety software). In a survey of UNCH nursing staff, respondents indicated they were having difficulty in accessing the library and (when necessary) in manually programming the new devices. The hospital's experience highlighted a number of key points for institutions to consider during the implementation of new smart-pump technology. The implementation of new smart-pump technology for epidural infusions at UNCH revealed the importance of pump features and design in determining the devices' impact on patient safety. In particular, factors pertaining to ease of use (e.g., protocol-selection functions, programming procedures, data recording and retrieval capabilities) are crucial to the overall success of smart-pump implementation.

  17. In vitro evaluation of hydraulic characteristics of prototype implantable intrathecal infusion pump.

    Science.gov (United States)

    Nam, Kyoung Won; Sung, Mun Hyun; Kim, Hyun Ho; Kim, Kwang Gi; Kim, Dae Hyun; Lee, Byeong Han; Jo, Yung Ho

    2010-12-01

    The use of the intrathecal infusion pump for therapeutic treatment and pain management is increasing. For example, one such application is the pain treatment of cancer patients suffering from severe chronic pain, where all other treatment methods have failed. This method is gaining popularity because of its high cure effect with low dosage. In this study, we developed a prototype implantable intrathecal infusion pump and evaluated its mechanical and hydraulic characteristics in vitro to determine how its performance varied under different environmental conditions. The data are reported as means (standard deviations). In the experiments, the prototype pump could control the micro-scale infusion amount, and its performance was affected by ambient temperature and pressure conditions. In a temperature change test, at a constant pressure of 1.0 atm, the minimal amounts of a bolus were 4.44 (1.07), 5.06 (1.17), and 5.54 (0.90) uL for the temperature of 27.5, 36.5, and 42°C, respectively. In a pressure change test, at a constant temperature of 36.5°C, the minimal amounts of a bolus were 5.06 (1.17), 5.94 (0.67), and 6.13 (0.39) uL for pressures of 1.0, 0.9 and 0.8 atm, respectively. These experimental results demonstrate the possibility of using the prototype pump as an implantable microvolumetric infusion device. However, this prototype pump will have to undergo further design enhancement before being clinically feasible for such an application.

  18. Changes in fat concentration of human milk during delivery by intermittent bolus and continuous mechanical pump infusion.

    Science.gov (United States)

    Greer, F R; McCormick, A; Loker, J

    1984-11-01

    The changes in fat concentration and cumulative fat losses that occur during the delivery of human milk using two different continuous infusion systems were compared with the changes in fat concentration during simulated intermittent gavage or bolus feedings. With both mechanical pumps the largest cumulative fat losses and the greatest decreases in fat concentrations occurred at the slowest infusion rates. State of homogenization of the milk generally made little difference in the changes in fat concentration using the syringe pump, whereas homogenizing the milk increased the fat concentration significantly with the roller pump. With the syringe pump the positioning of the syringe tip (horizontal or vertical) made no difference in fat concentration at an infusion rate of 1 ml/hr, whereas at 4 and 7 ml/hr the fat concentration was increased significantly by keeping the syringe tip vertical. With either mechanical pump a large fat bolus was delivered during the eighth and final hour of infusion if the milk remaining in the tubing was recovered by using air infusion at the same infusion rate. Intermittent bolus delivery of human milk resulted in no significant loss of human milk fat, no changes in fat concentration, and no terminal delivery of a large fat load. Thus intermittent bolus feedings are preferred over continuous mechanical pump infusion systems for the delivery of human milk to low-birth-weight infants.

  19. Prolonged intracerebral convection-enhanced delivery of topotecan with a subcutaneously implantable infusion pump.

    Science.gov (United States)

    Sonabend, Adam M; Stuart, R Morgan; Yun, Jonathan; Yanagihara, Ted; Mohajed, Hamed; Dashnaw, Steven; Bruce, Samuel S; Brown, Truman; Romanov, Alex; Sebastian, Manu; Arias-Mendoza, Fernando; Bagiella, Emilia; Canoll, Peter; Bruce, Jeffrey N

    2011-08-01

    Intracerebral convection-enhanced delivery (CED) of chemotherapeutic agents currently requires an externalized catheter and infusion system, which limits its duration because of the need for hospitalization and the risk of infection. To evaluate the feasibility of prolonged topotecan administration by CED in a large animal brain with the use of a subcutaneous implantable pump. Medtronic Synchromed-II pumps were implanted subcutaneously for intracerebral CED in pigs. Gadodiamide (28.7 mg/mL), with or without topotecan (136 μM), was infused at 0.7 mL/24 h for 3 or 10 days. Pigs underwent magnetic resonance imaging before and at 6 times points after surgery. Enhancement and FLAIR+ volumes were calculated in a semi-automated fashion. Magnetic resonance spectroscopy-based topotecan signature was also investigated. Brain histology was analyzed by hematoxylin and eosin staining and with immunoperoxidase for a microglial antigen. CED of topotecan/gadolinium was well tolerated in all cases (n = 6). Maximum enhancement volume was reached at day 3 and remained stable if CED was continued for 10 days, but it decreased if CED was stopped at day 3. Magnetic resonance spectroscopy revealed a decrease in parenchymal metabolites in the presence of topotecan. Similarly, the combination of topotecan and gadolinium infusion led to a FLAIR+ volume that tended to be larger than that seen after the infusion of gadolinium alone. Histological analysis of the brains showed an area of macrophage infiltrate in the ipsilateral white matter upon infusion with topotecan/gadolinium. Intracerebral topotecan CED is well tolerated in a large animal brain for up to 10 days. Intracerebral long-term CED can be achieved with a subcutaneously implanted pump and provides a stable volume of distribution. This work constitutes a proof of principle for the safety and feasibility for prolonged CED, providing a means of continuous local drug delivery that is accessible to the practicing neuro-oncologist.

  20. Continuous subcutaneous infusion of glucagon by portable pump in non beta cell tumor hypoglycemia.

    Science.gov (United States)

    Houlbert, D; Altman, J J; Lageron, A; Capeau, J; Dahan, R; Friedberg, G; Wassef, M; Poffenbarger, P L; Segrestaa, J M

    1985-04-01

    Subcutaneous infusion of glucagon by portable pump appears to give very effective symptomatic relief from non beta cell tumor hypoglycemia when surgery, radiotherapy and chemotherapy are impossible or ineffective. This mode of glucagon administration was proposed in a patient who had severe nocturnal hypoglycemic attacks. The aim of the study was to specify the modes of utilization and to test the efficiency and the tolerance of this treatment. Glucagon was infused at 400 micrograms/h during every 12 hour night. Because of the hepatic action of glucagon it is very important to use this treatment with an adequate diet and to stop the infusion during the day to reconstitute the glycogen overload. This mode of glucagon administration was very effective in over 6 months of use and well tolerated.

  1. Specification and simulation of behavior of the Continuous Infusion Insulin Pump system.

    Science.gov (United States)

    Babamir, Seyed Morteza; Dehkordi, Mehdi Borhani

    2014-01-01

    Continuous Infusion Insulin Pump (CIIP) system is responsible for monitoring diabetic blood sugar. In this paper, we aim to specify and simulate the CIIP software behavior. To this end, we first: (1) presented a model consisting of the CIIP system behavior in response to its environment (diabetic) behavior and (2) we formally defined the safety requirements of the system environment (diabetic) in the Z formal modeling language. Such requirements should be satisfied by the CIIP software. Finally, we programmed the model and requirements.

  2. Development of an implantable infusion pump for sustained anti-HIV drug administration.

    Science.gov (United States)

    Baert, Lieven; Schueller, Laurent; Tardy, Yanik; Macbride, Doug; Klooster, Gerben van't; Borghys, Herman; Clessens, Ellen; Van Den Mooter, Guy; Van Gyseghem, Elke; Van Remoortere, Pieter; Wigerinck, Piet; Rosier, Jan

    2008-05-01

    Factors such as insufficient drug potency, non-compliance and restricted tissue penetration contribute to incomplete suppression of Human Immunodeficiency Virus (HIV) and the difficulty to control this infection. Infusion via standard catheters can be a source of infection, which is potentially life threatening in these patients. We developed an implantable infusion pump, allowing to accommodate large volumes (16-50mL) of high viscous solutions (up to 23.96mPas at 39 degrees C) of anti-HIV agents and providing sustained release of medication: a standard Codman 3000 pump, which was initially developed to release aqueous solutions ( approximately 0.7mPas) into the spinal cord such as for pain medication, was transformed for release of viscous solutions up to 40mPas by adapting the diameter of the capillary flow restrictor, the capillary length and way of catheterisation--by placing the indwelling catheter in the vena cava. A pilot study of the pump implanted in 2 dogs showed continuous steady-state release of the protease inhibitor darunavir (25mg/dog/day administered for 25 days), thereby achieving plasma concentration levels of approximately 40ng/mL. Steady-state plasma levels were reproducible after monthly refill of the pumps. In conclusion, the implantable adapted Codman 3000 constant-flow infusion pump customized to anti-HIV therapy allows sustained release of anti-HIV medication and may represent an opportunity to reduce the pill burden and complexity of dosing schemes associated with common anti-HIV therapy.

  3. Organizational, Cultural, and Psychological Determinants of Smart Infusion Pump Work Arounds: A Study of 3 U.S. Health Systems.

    Science.gov (United States)

    Dunford, Benjamin B; Perrigino, Matthew; Tucker, Sharon J; Gaston, Cynthia L; Young, Jim; Vermace, Beverly J; Walroth, Todd A; Buening, Natalie R; Skillman, Katherine L; Berndt, Dawn

    2017-09-01

    We investigated nurse perceptions of smart infusion medication pumps to provide evidence-based insights on how to help reduce work around and improve compliance with patient safety policies. Specifically, we investigated the following 3 research questions: (1) What are nurses' current attitudes about smart infusion pumps? (2) What do nurses think are the causes of smart infusion pump work arounds? and (3) To whom do nurses turn for smart infusion pump training and troubleshooting? We surveyed a large number of nurses (N = 818) in 3 U.S.-based health care systems to address the research questions above. We assessed nurses' opinions about smart infusion pumps, organizational perceptions, and the reasons for work arounds using a voluntary and anonymous Web-based survey. Using qualitative research methods, we coded open-ended responses to questions about the reasons for work arounds to organize responses into useful categories. The nurses reported widespread satisfaction with smart infusion pumps. However, they reported numerous organizational, cultural, and psychological causes of smart pump work arounds. Of 1029 open-ended responses to the question "why do smart pump work arounds occur?" approximately 44% of the causes were technology related, 47% were organization related, and 9% were related to individual factors. Finally, an overwhelming majority of nurses reported seeking solutions to smart pump problems from coworkers and being trained primarily on the job. Hospitals may significantly improve adherence to smart pump safety features by addressing the nontechnical causes of work arounds and by providing more leadership and formalized training for resolving smart pump-related problems.

  4. Failure mode effect analysis applied to the use of infusion pumps.

    Science.gov (United States)

    Fechter, Richard J; Barba, Julio J

    2004-01-01

    Failure Mode Effect Analysis (FMEA) offers a prospective approach to reducing the risk associated with health care delivery. Beginning in February, 2002, an interdisciplinary team of fifteen individuals, including end-users, conducted an FMEA for the use of infusion pumps at UCSF Medical Center. The use of infusion pumps was identified as the area of highest risk, based on incident report data. The team identified sixteen potential failure modes, including their potential effects and causes, and assigned a risk priority number to each based on the potential severity, probability, and detectability of the failure. Notable failure modes included: incorrect programming; improper or inconsistent labeling of solution, tubing, and pump; potential use of malfunctioning or damaged pumps; and incorrect programming by nurses related to device design. The team then broke into smaller work groups and invited more end-users to perform root cause analyses and suggest recommended actions/outcome measures for each failure mode with a risk priority number of 32 or higher (on our scale of 1 to 64). Finally, the FMEA team assembled all of the data, prepared a final report, and assigned responsibility for key recommended actions.

  5. Tolerability, safety and efficacy of Iloprost infusion without peristaltic pump in systemic sclerosis

    Directory of Open Access Journals (Sweden)

    S. Tosi

    2011-09-01

    Full Text Available Objective. To evaluate safety, tolerability and efficacy on Raynaud’s phenomenon (Rp of iloprost infusion without peristaltic pump in patients with systemic sclerosis (SSc. Patients and methods. The inclusion criteria were diagnosis of SSc, age between 18 and 65 years, presence of Rp, and absence of any controindication to the use of iloprost. The treatment was carried out in a day hospital setting and consisted first of 5 consecutive days of iloprost infusion (from an initial dose of 1.0 ng/Kg/min up to 2 ng/kg/min, and then of 2 days of infusions at the maximum possible dose every 45 days for one year. All of the adverse events were carefully recorded and the changes in the Rp were measured by a 5 grade scale (worsened, unmodified, slightly improved, very improved, disappeared. Results. Thirty-eight SSc patients (all females, mean age 49 years (range 18.5-65, disease duration 1.5 years (range 0.5-10.8 were enrolled in the study. During the first cycle of therapy, 14 avderse events occurred in 11 (28.9% patients and during the next cycles, 3 adverse events were seen in 3 (7.9% patients. In all of the cases they were mild and transient. Rp was considered very improved in 15 (39.5% patients, slightly improved in 13 (34.2%, unmodified in 8 (21% and worse in 2 (5.2%. Discussion. In this study intravenous iloprost without peristaltic pump proved to be safe, well tolerated, and as effective as traditional infusion through peristaltic pump in improving Rp in patients with SSc.

  6. Infusion pumps and red blood cell damage in transfusion therapy: an integrative revision of the academic literature 1

    Science.gov (United States)

    Wilson, Ana Maria Miranda Martins; Peterlini, Maria Angélica Sorgini; Pedreira, Mavilde da Luz Gonçalves

    2016-01-01

    ABSTRACT Objectives: to obtain information from scientific literature concerning infusion pumps used in administering erythrocyte (red blood cells) and to evaluate the implications in the practical use of this equipment by nurses when conducting transfusions. Method: an integrative revision of the following scientific databases: Pubmed/Medline, Scopus, the Virtual Library for Health, SciELO, Web of Science and Cochrane. The following descriptors were used: "infusion pumps", "blood transfusion", "transfused erythrocyte" and "hemolyis". There were no restrictions on the scope of the initial data and it was finalized in December 2014. 17 articles were identified in accordance with the inclusion and exclusion criteria. Results: all of the publications included in the studies were experimental in vitro and covered the use of infusion pumps in transfusion therapy. A summary of the data was presented in a synoptic chart and an analysis of it generated the following categories: cellular damage and the infusion mechanism. Conclusion: infusion pumps can be harmful to erythrocytes based on the infusion mechanism that is used, as the linear peristaltic pump is more likely to cause hemolysis. Cellular damage is related to the plasmatic liberation of markers that largely dominate free hemoglobin and potassium. We reiterate the need for further research and technological investments to guide the development of protocols that promote safe practices and that can contribute to future clinical studies. PMID:27533272

  7. Infusion pumps and red blood cell damage in transfusion therapy: an integrative revision of the academic literature

    Directory of Open Access Journals (Sweden)

    Ana Maria Miranda Martins Wilson

    Full Text Available ABSTRACT Objectives: to obtain information from scientific literature concerning infusion pumps used in administering erythrocyte (red blood cells and to evaluate the implications in the practical use of this equipment by nurses when conducting transfusions. Method: an integrative revision of the following scientific databases: Pubmed/Medline, Scopus, the Virtual Library for Health, SciELO, Web of Science and Cochrane. The following descriptors were used: "infusion pumps", "blood transfusion", "transfused erythrocyte" and "hemolyis". There were no restrictions on the scope of the initial data and it was finalized in December 2014. 17 articles were identified in accordance with the inclusion and exclusion criteria. Results: all of the publications included in the studies were experimental in vitro and covered the use of infusion pumps in transfusion therapy. A summary of the data was presented in a synoptic chart and an analysis of it generated the following categories: cellular damage and the infusion mechanism. Conclusion: infusion pumps can be harmful to erythrocytes based on the infusion mechanism that is used, as the linear peristaltic pump is more likely to cause hemolysis. Cellular damage is related to the plasmatic liberation of markers that largely dominate free hemoglobin and potassium. We reiterate the need for further research and technological investments to guide the development of protocols that promote safe practices and that can contribute to future clinical studies.

  8. Needle and catheter colonization in pregnant diabetic patients using the continuous subcutaneous insulin infusion pump.

    Science.gov (United States)

    Rivera-Alsina, M E; Willis, S

    1984-01-01

    The incidence of bacterial colonization and risk of infection associated with the use of continuous insulin infusion pump (CIIP) was examined in 11 pregnant diabetic patients. All patients received instruction on specific aspects of CIIP and needle insertion technique according to the protocol used in our institution. A total of 220 cultures was performed on the subcutaneous needle and connective tubing. There was no clinical evidence of infection. In conclusion, the risk of infectious cutaneous complications in the pregnant diabetic patient using CIIP is not increased over the nonpregnant diabetic population.

  9. Use of an oil-hydraulic microinjection pump for subretinal infusions.

    Science.gov (United States)

    Weichel, Judith; Valtink, Monika; Engelmann, Katrin; Richard, Gisbert

    2002-01-01

    The injection of cell suspensions or drugs into the subretinal space is a new promising option of vitreoretinal surgery for the treatment of degenerative retinal disorders. We used a manual oil-hydraulic microinjection pump to subretinally inject suspensions of retinal pigment epithelial cells in Royal College of Surgeons rats and in patients suffering from age-related macular degeneration with geographic atrophy. The histological examination of the treated rat eyes showed that cell suspensions could be placed precisely in the subretinal space. Intra- and postoperative outcome of the patients in the clinical trial revealed no retinal complications during 6 months of follow up. We suggest the oil-hydraulic microinjection pump to be a valuable instrument for controlled and precisely dosed atraumatic infusion or aspiration of small volumes of cell suspensions, fluids or drugs in vitreoretinal surgery.

  10. Catheter Migration After Implantationan Intrathecal Baclofen Infusion Pump for Severe Spasticity: A Case Report

    Directory of Open Access Journals (Sweden)

    Tung-Chou Li

    2008-09-01

    Full Text Available We report a case of intrathecal baclofen infusion pump implantation complicated by migration of the catheter tip. A 55-year-old man required an intrathecal baclofen infusion for severe spasticity 4 years after a cervical spinal cord injury with incomplete tetraparesis. Twelve months after initial implantation of the device, the patient began to experience a recurrence of trunk tightness and spasticity. Subsequent X-ray and computed tomography evaluations of the catheter system revealed pooling of contrast medium outside of the intrathecal distribution in the lumbar subcutaneous region of the back and therefore migration of the pump catheter tip. At surgical revision, emphasis was placed on minimizing the length of catheter outside of the spine and securing the catheter in the supraspinous fascia with a right-angled anchor. The distance between the anchors and the entry point of the catheter into the supraspinous fascia was also reduced to prevent slipping when the patient bends forward. After surgery, the patient's spasticity improved and, 1 year later, he has experienced no further complications during follow-up, requiring an average baclofen dose of 150 mg/day. Here, we describe several surgical methods intended to secure the intrathecal catheter and prevent catheter migration. Other complications related to catheter failure are also highlighted.

  11. Hepatic arterial infusion pump chemotherapy for colorectal liver metastases: an old technology in a new era.

    Science.gov (United States)

    Ko, Y J; Karanicolas, P J

    2014-02-01

    Aggressive treatment of colorectal cancer (crc) liver metastases can yield long-term survival and cure. Unfortunately, most patients present with technically unresectable metastases; conventional therapy in such patients consists of systemic therapy. Despite advances in the effectiveness of systemic therapy in the first-line setting, the tumour response rate and median survival remain low in the second-line setting. The preferential blood supply from the hepatic artery to crc liver metastases allows for excellent regional delivery of chemotherapy. Here, we review efficacy and safety data for hepatic artery infusion (hai) pump chemotherapy in patients with metastatic crc from the 5-fluorouracil era and from the era of modern chemotherapy. In selected patients with liver-only or liver-dominant disease who have progressed on first-line chemotherapy, hai combined with systemic agents is a viable therapeutic option when performed at experienced centres. Furthermore, significantly improved survival has been demonstrated with adjuvant hai therapy after liver resection in the phase iii setting. The complication rates and local toxicities associated with hai pump therapy are infrequent at experienced centres and can be managed with careful follow-up and early intervention. The major obstacles to the wide adoption of hai therapy include technical expertise for pump insertion and maintenance, and for floxuridine dose modification. The creation of formal preceptor-focused education and training in hai therapy for interdisciplinary medical professionals might encourage the creation and expansion of this liver-directed approach.

  12. An adjustable flow restrictor for implantable infusion pumps based on porous ceramics.

    Science.gov (United States)

    Jannsen, Holger; Klein, Stephan; Nestler, Bodo

    2015-08-01

    This paper describes an adjustable flow restrictor for use in gas-driven implantable infusion pumps, which is based on the resistance of a flow through a porous ceramic material. The flow inside the walls of a ceramic tube can be adjusted between 270 nl/min and 1260 nl/min by changing the flow path length in the ceramic over a distance of 14 mm. The long-term stability of the flow restrictor has been analyzed. A drift of -8% from the nominal value was observed, which lies within the required tolerance of ±10% after 30 days. The average time needed to change the flow rate is 40 s. In addition, the maximum adjustment time was 110 s, which also lies within the specification.

  13. Methods for studying medical device technology and practitioner cognition : The case of user-interface issues with infusion pumps

    NARCIS (Netherlands)

    Schraagen, J.M.C.; Verhoeven, F.

    2013-01-01

    Purpose : The aims of this study were to investigate how a variety of research methods is commonly employed to study technology and practitioner cognition. User-interface issues with infusion pumps were selected as a case because of its relevance to patient safety. Methods : Starting from a Cognitiv

  14. Methods for studying medical device technology and practitioner cognition: the case of user-interface issues with infusion pumps

    NARCIS (Netherlands)

    Schraagen, J.M.C.; Verhoeven, F.

    2013-01-01

    Purpose The aims of this study were to investigate how a variety of research methods is commonly employed to study technology and practitioner cognition. User-interface issues with infusion pumps were selected as a case because of its relevance to patient safety. Methods Starting from a Cognitive S

  15. Insulin pump-associated adverse events are common, but not associated with glycemic control, socio-economic status, or pump/infusion set type.

    Science.gov (United States)

    Ross, P; Gray, A R; Milburn, J; Kumarasamy, I M; Wu, F; Farrand, S; Armishaw, J; Wiltshire, E; Rayns, J; Tomlinson, P; Wheeler, B J

    2016-12-01

    While there have been many outcome-focussed studies examining insulin pump therapy, only a few have looked at potential adverse events (AEs), with none examining the relationship between AEs and pump/infusion set type, ethnicity or socio-economic status. In addition, current data on the incidence and characteristics of pump-associated AEs are confined to one paediatric centre. We aimed to describe the incidence, characteristics and potential predictors of insulin pump-associated AEs in New Zealand adults and children with T1DM. We approached adults and families of children with T1DM on insulin pumps in four main New Zealand centres. Participants completed a questionnaire examining pump-related issues they had experienced in the preceding 12 months. Response rate was 64 % with 174 of 270 eligible people participating in the study. 84 % of subjects reported one or more AEs, with an overall AE incidence of 3.42 per person/year (95 % CI 3.14, 3.73). An event serious enough to require a hospital presentation occurred in 9.8 %, all but one reporting high ketones or diabetic ketoacidosis (DKA). Set/site problems were the AE most commonly reported (by 53 % of respondents), followed by cutaneous complications (43 %) and pump malfunction (38 %). Few predictors of AEs (of any type) were found; however, a negative binomial regression model found that a longer duration of pumping (p = 0.018) and age Insulin pump-associated AEs are very common. However, few variables are predictive of them with no relationships seen with glycaemic control, socio-economic status, pump manufacturer or infusion set type. Based on these findings, AEs should be anticipated in both adults and children, with anticipatory patient education and training recommended for their successful and safe use.

  16. Analysis of Temperature's Influence on a Digital Displacement Pump's Volumetric Efficiency

    DEFF Research Database (Denmark)

    Pedersen, Henrik C.; Johansen, Per; Yigen, Cemre;

    2012-01-01

    The focus of the current paper is on a small 18 cm3/rev Digital Displacement Pump (DDP), where it is investigated how temperature influency the pump behaviour and static performance. An experimentally validated model of the DDP is presented, which is the basis for the investigation. From the resu...

  17. Radical resection for low rectal carcinoma combined with infusion pump chemotherapy via internal iliac artery

    Directory of Open Access Journals (Sweden)

    Bo YANG

    2011-10-01

    Full Text Available Objective To evaluate the effects and practicability of radical resection for low rectal carcinoma with infusion pump chemotherapy via internal iliac artery,and explore the correlation factors influencing the therapeutic effects.Methods Data of 316 patients with low rectal carcinoma,admitted from Oct.1997 to Mar.2008,were retrospectively analyzed and assigned into 2 groups according to the treatment: Patients received infusion pump chemotherapy via internal iliac artery to target area combined with intravenous systemic chemotherapy were assigned into group A(n=249,and those receiving systemic chemotherapy alone following radical resection were assigned to group B(n=67.The timing of pump chemotherapy to target area in group A was set at day 12 after recovery of digestive function,with regimen of 5-FU at 0.5g per dose plus hydroxycamptothecin at 10-15mg per dose,twice a week,four times as a treatment course for a total of 6 courses,and it was followed by intravenously systemic chemotherapy with a regimen of FOLFIRI or FOLFOX.In group B,at day 12 right after recovery of digestive function,the intravenous sytemic chemotherapy was started with the same regimen as in group A.The local recurrence rate,metastasis rate and survival rate after 1,3 and 5 years in the two groups were respectively observed and compared,and the correlation between the clinicopathological features and the 5 year local recurrence rates and survival rates was analyzed in patients of group A.Results In group A,the local recurrence rate at year 1,3 and 5 was 0,1.68%(4/238 and 3.79%(8/211,respectively,the metastasis rate was 0.80%(2/249,4.62%(11/238 and 10.90%(23/211,respectively,and the survival rate was 100%,77.73%(185/238 and 72.04%(152/211,respectively.In group B,the local recurrence rate at year 1,3 and 5 was 0,9.52%(6/63 and 16.36%(9/55,respectively,the metastasis rate was 1.49%(1/67,15.87%(10/63 and 27.27%(15/55,respectively,and the survival rate was 100

  18. Success With Extended-Infusion Meropenem After Recurrence of Baclofen Pump-Related Achromobacter Xylosoxidans Meningitis in an Adolescent.

    Science.gov (United States)

    Nichols, Kristen R; Knoderer, Chad A; Jackson, Nicholas G; Manaloor, John J; Christenson, John C

    2015-08-01

    A 13-year-old female experienced a recurrence of baclofen pump-related central nervous system (CNS) infection caused by Achromobacter, despite absence of retained foreign material. Due to the failure of meropenem (120 mg/kg/d in divided doses every 8 hours and infused over 30 minutes) in the initial infection, the dose was infused over 4 hours during the recurrence. Meropenem is an antibiotic for which efficacy is time dependent, and 4-hour versus 30-minute infusions have been shown to prolong the time the concentration of the antibiotic exceeds the minimum inhibitory concentration (MIC) of the organism at the site of infection (T>MIC). Meropenem serum concentrations were obtained and indicated that T>MIC was at least 75% of the dosing interval. Our patient improved with no noted recurrences or adverse effects on the extended-infusion meropenem regimen. Utilization of extended-infusion beta-lactam dosing whenever possible in the treatment of serious infections caused by gram-negative organisms should be considered, as this dosing appears to be safe and improves the probability of achieving pharmacokinetic/pharmacodynamic goals.

  19. Testing and Discussion of Infusion Pump Based on Open Consumables%开放耗材输液泵的流速测试和讨论

    Institute of Scientific and Technical Information of China (English)

    张飚瑞

    2013-01-01

    Infusion pumps are commonly used in clinical,especially the open consumable infusion pumps,the consumable part of which adopting the gravity sets.However,dedicated infusing outfit is necessary for infusion pumps,so as to ensure the accuracy of the flow rate.Three kinds of infusion pipe were tested in 2 sets of infusion pump,and the results and relevant problems about flow rate of infusion pump are discussed in this paper.%输液泵在临床领域普遍使用,目前临床上使用的多是开放耗材输液泵,其耗材使用的都是重力输液器,而输液泵应该有专用的输液器,这样才能保证流速的精度.本文选取了3种不同的输液管路在2台输液泵上做测试,就测试结果和输液泵流速的相关问题进行讨论.

  20. Drug delivery: enabling technology for drug discovery and development.iPRECIO® Micro Infusion Pump: Programmable, refillable and implantable

    Directory of Open Access Journals (Sweden)

    Tsung eTan

    2011-07-01

    Full Text Available Successful drug delivery using implantable pumps may be found in over 12,500 published articles. Their versatility in delivering continuous infusion, intermittent or complex infusion protocols acutely or chronically has made them ubiquitous in drug discovery and basic research. The recent availability of iPRECIO®, a programmable, refillable and implantable infusion pump has made it possible to carry out quantitative pharmacology (PKPD in single animals. When combined with specialized catheters, specific administration sites have been selected. When combined with radiotelemetry, the physiologic gold standard, more sensitive and powerful means of detecting drug induced therapeutic and/or adverse effects has been possible. Numerous application examples are cited from iPRECIO® use in Japan, United States and Europe with iPRECIO® as an enabling drug delivery device where the refillable and programmability functionality were key benefits. The ability to start/stop drug delivery and to have control periods prior dosing made it possible to have equivalent effects at a much lower dose than previously studied. Five different iPRECIO® applications are described in detail with references to the original work where the implantable, refillable and programmable benefits are demonstrated with their different end-points.

  1. Drug Delivery: Enabling Technology for Drug Discovery and Development. iPRECIO Micro Infusion Pump: Programmable, Refillable, and Implantable.

    Science.gov (United States)

    Tan, Tsung; Watts, Stephanie W; Davis, Robert Patrick

    2011-01-01

    Successful drug delivery using implantable pumps may be found in over 12,500 published articles. Their versatility in delivering continuous infusion, intermittent or complex infusion protocols acutely or chronically has made them ubiquitous in drug discovery and basic research. The recent availability of iPRECIO(®), a programmable, refillable, and implantable infusion pump has made it possible to carry out quantitative pharmacology (PKPD) in single animals. When combined with specialized catheters, specific administration sites have been selected. When combined with radiotelemetry, the physiologic gold standard, more sensitive and powerful means of detecting drug induced therapeutic, and/or adverse effects has been possible. Numerous application examples are cited from iPRECIO(®) use in Japan, United States, and Europe with iPRECIO(®) as an enabling drug delivery device where the refillable and programmability functionality were key benefits. The ability to start/stop drug delivery and to have control periods prior dosing made it possible to have equivalent effects at a much lower dose than previously studied. Five different iPRECIO(®) applications are described in detail with references to the original work where the implantable, refillable, and programmable benefits are demonstrated with their different end-points.

  2. Impact Analysis of Infusion Apparatus on Precision of Infusion Pump%浅谈医用输液器的质量对输液泵输液精度的影响

    Institute of Scientific and Technical Information of China (English)

    郭召平; 张祖进; 李辉

    2012-01-01

    Objective To analyze the impact of infusion apparatus on the precision of infusion pump. Methods The different infusion apparatuses were tested in the same circumstance by Datrend 2000E infusion analyzer. Results Imported infusion pump demanded more precise infusion apparatus, and the precision of homemade infusion pump was debasing in the application. Conclusion The application conditions of homemade infusion pump are realized by testing infusion apparatus. [Chinese Medical Equipment Journal,2012,33(7): 113-114]%目的:分析医用输液器的质量对输液泵输液精度的影响.方法:利用瑞典奥利科输液泵质量检测仪对输液器进行检测.结果:进口输液泵对输液器质量要求比较高,有些用国产输液器无法进行标定,要采用专门管道才能达到使用精度,对国产输液器兼容性比较差.国产输液泵虽然有些是全兼容国产输液器,但是使用过程中的精度将会降低.结论:通过对输液器的检测,了解国内输液泵的使用情况,要使用弹性好、质量好的输液器才能达到输液精度.

  3. Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps.

    Science.gov (United States)

    Sajadi, Ahmadali; Provost, Chloé; Pham, Brendon; Brouillette, Jonathan

    2016-08-14

    Decline in hippocampal-dependent explicit memory (memory for facts and events) is one of the earliest clinical symptom of Alzheimer's disease (AD). It is well established that synapse loss and ensuing neurodegeneration are the best predictors for memory impairments in AD. Latest studies have emphasized the neurotoxic role of soluble amyloid-beta oligomers (Aβo) that begin to accumulate in the human brain approximately 10 to 15 yr before the clinical symptoms become apparent. Many reports indicate that soluble Aβo correlate with memory deficits in AD models and humans. The Aβo-induced neurodegeneration observed in neuronal and brain slice cultures has been more challenging to reproduce in many animal models. The model of repeated Aβo infusions shown here overcome this issue and allow addressing two key domains for developing new disease modifying therapies: identify biological markers to diagnose early AD, and determine the molecular mechanisms underpinning Aβo-induced memory deficits at the onset of AD. Since soluble Aβo aggregate relatively fast into insoluble Aβ fibrils that correlate poorly with the clinical state of patients, soluble Aβo are prepared freshly and injected once per day during six days to produce marked cell death in the hippocampus. We used cannula specially design for simultaneous infusions of Aβo and continuous infusion of Aβo antibody (6E10) in the hippocampus using osmotic pumps. This innovative in vivo method can now be used in preclinical studies to validate the efficiency of new AD therapies that might prevent the deposition and neurotoxicity of Aβo in pre-dementia patients.

  4. Efeito da bomba de infusão de soluções sobre o grau de hemólise em concentrados de hemácias Effect of the infusion pumps of solutions on the degree of hemolysis

    Directory of Open Access Journals (Sweden)

    Eunice B. Carvalho

    2007-06-01

    mechanical trauma due to the use of different models of infusion pumps, on red blood cells transfused after up to ten days of storage. Three models of pumps were studied (Nutrimat, Infusomat Compact and Volumed, (four devices of each model with three infusion speeds being tested (120 mL/h, 240 mL/h and 360 mL/h. The parameters used to report the degree of hemolysis were the percentile of hemolysis, hemoglobin levels and free potassium in the plasma. Samples were collected before infusion of red blood cells using the pumps, half way through infusion (1/2 T and at the end of infusion (T, for the three different speeds. Significant variations were not seen in the analyzed parameters between the control samples and those collected at different speeds, using different models of pumps and infusion mechanisms and among pumps of the same brand and at different infusion times. The greatest variation found involved free potassium, probably due to the different levels found in red blood cell concentrates seen when control samples were compared to values obtained half way through and at the end of infusion for each pump. In agreement with the obtained results changes in the percentile of hemolysis were not found after infusion of the cells using the different infusion pumps.

  5. Infusion pumps and red blood cell damage in transfusion therapy: an integrative revision of the academic literature.

    Science.gov (United States)

    Wilson, Ana Maria Miranda Martins; Peterlini, Maria Angélica Sorgini; Pedreira, Mavilde da Luz Gonçalves

    2016-08-15

    to obtain information from scientific literature concerning infusion pumps used in administering erythrocyte (red blood cells) and to evaluate the implications in the practical use of this equipment by nurses when conducting transfusions. an integrative revision of the following scientific databases: Pubmed/Medline, Scopus, the Virtual Library for Health, SciELO, Web of Science and Cochrane. The following descriptors were used: "infusion pumps", "blood transfusion", "transfused erythrocyte" and "hemolyis". There were no restrictions on the scope of the initial data and it was finalized in December 2014. 17 articles were identified in accordance with the inclusion and exclusion criteria. all of the publications included in the studies were experimental in vitro and covered the use of infusion pumps in transfusion therapy. A summary of the data was presented in a synoptic chart and an analysis of it generated the following categories: cellular damage and the infusion mechanism. infusion pumps can be harmful to erythrocytes based on the infusion mechanism that is used, as the linear peristaltic pump is more likely to cause hemolysis. Cellular damage is related to the plasmatic liberation of markers that largely dominate free hemoglobin and potassium. We reiterate the need for further research and technological investments to guide the development of protocols that promote safe practices and that can contribute to future clinical studies. identificar na literatura a produção científica acerca dos efeitos de bomba de infusão na administração de hemácias e avaliar as implicações do uso desses equipamentos na prática transfusional de enfermagem. revisão integrativa de literatura nas bases de dados Pubmed/Medline, Scopus, Biblioteca Virtual em Saúde, SciELO, Web of Science e Cochrane, utilizando os descritores "bombas de infusão", "transfusão de sangue", "transfusão de eritrócitos" e "hemólise". A data inicial não foi delimitada e a final foi dezembro de

  6. The design and development of half extrusion type intelligent infusion pump%半挤压式智能输液泵的设计与研制

    Institute of Scientific and Technical Information of China (English)

    张彬; 李海云

    2015-01-01

    Aimed for the problems of traditional intravenous infusion in convenience, safety and reliability, half extrusion type intelligent infusion pump, a kind of piston infusion pump, was designed and developed in this paper. It stands out because of its portability, reliability, precise velocity control and transfusion status monitoring and alarm. The article first introduces the traditional intravenous fluids and the classification and principle of infusion pump, then the principle of infusion pump and the concrete structure design of half extrusion type piston is described in detail. Besides, the infusion velocity control methods are derived and the velocity precision of the half extrusion type intelligent infusion pump was successfully verified to be satisfying by the experiments.%针对传统静脉输液在便捷性、安全性与可靠性等方面的问题,本文设计并研制了半挤压式智能输液泵。它是一种活塞式输液泵,具有便携、操作简单可靠、流速控制精确等突出优点,并能对输液状态进行监测并报警。文章中首先介绍了传统静脉输液的不足以及输液泵的分类和原理,其次详细说明了半挤压式智能输液泵的工作原理及具体结构设计,然后对输液流速控制方法进行推导,最终通过实验成功证明半挤压式智能输液泵的输液流速精度满足设计要求。

  7. Designing the modern pump: engineering aspects of continuous subcutaneous insulin infusion software.

    Science.gov (United States)

    Welsh, John B; Vargas, Steven; Williams, Gary; Moberg, Sheldon

    2010-06-01

    Insulin delivery systems attracted the efforts of biological, mechanical, electrical, and software engineers well before they were commercially viable. The introduction of the first commercial insulin pump in 1983 represents an enduring milestone in the history of diabetes management. Since then, pumps have become much more than motorized syringes and have assumed a central role in diabetes management by housing data on insulin delivery and glucose readings, assisting in bolus estimation, and interfacing smoothly with humans and compatible devices. Ensuring the integrity of the embedded software that controls these devices is critical to patient safety and regulatory compliance. As pumps and related devices evolve, software engineers will face challenges and opportunities in designing pumps that are safe, reliable, and feature-rich. The pumps and related systems must also satisfy end users, healthcare providers, and regulatory authorities. In particular, pumps that are combined with glucose sensors and appropriate algorithms will provide the basis for increasingly safe and precise automated insulin delivery-essential steps to developing a fully closed-loop system.

  8. Guidelines for Application of Continuous Subcutaneous Insulin Infusion (Insulin Pump) Therapy in the Perioperative Period

    Science.gov (United States)

    Boyle, Mary E; Seifert, Karen M; Beer, Karen A; Apsey, Heidi A; Nassar, Adrienne A; Littman, Stephanie D; Magallanez, Janice M; Schlinkert, Richard T; Stearns, Joshua D; Hovan, Michael J; Cook, Curtiss B

    2012-01-01

    Case reports indicate that diabetes patients receiving outpatient insulin pump therapy have been allowed to continue treatment during surgical procedures. Although allowed during surgery, there is actually little information in the medical literature on how to manage patients receiving insulin pump therapy during a planned surgical procedure. A multidisciplinary work group reviewed current information regarding the use of insulin pumps in the perioperative period. Although the work group identified safety issues specific to surgical scenarios, it believed that with the use of standardized guidelines and a checklist, continuation of insulin pump therapy during the perioperative period is feasible. A sample set of protocols have been developed and are summarized. A policy outlining clear procedures should be established at the institutional level to guide physicians and other staff if the devices are to be employed during the perioperative period. Additional clinical experience with the technology in surgical scenarios is needed, and consensus should be developed for insulin pump use in the perioperative phases of care. PMID:22401338

  9. Combining situated Cognitive Engineering with a novel testing method in a case study comparing two infusion pump interfaces.

    Science.gov (United States)

    Schnittker, R; Schmettow, M; Verhoeven, F; Schraagen, J M C

    2016-07-01

    We validated the usability of a new infusion pump interface designed with a situated Cognitive Engineering approach by comparing it to a reference interface using a novel testing method employing repeated measurements and process measures, in addition to traditional outcome measures. The sample consisted of 25 nurses who performed eight critical tasks three times. Performance measures consisted of number and type of errors, deviations from a pre-established normative path solution, task completion times, number of keystrokes, mental effort and preferences in use. Results showed that interaction with the new interface resulted in 18% fewer errors, 90% fewer normative path deviations, 42% lower task completion times, 40% fewer keystrokes, 39% lower mental effort and 76% more subjective preferences in use. These outcomes suggest that within the scope of this case study, combining the situated Cognitive Engineering approach with a novel testing method addresses various shortcomings of earlier testing methods. Copyright © 2016 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  10. Establishing glycaemic control with continuous subcutaneous insulin infusion in children and adolescents with type 1 diabetes : experience of the PedPump Study in 17 countries

    NARCIS (Netherlands)

    Danne, T.; Battelino, T.; Jarosz-Chobot, P.; Kordonouri, O.; Pankowska, E.; Ludvigsson, J.; Schober, E.; Kaprio, E.; Saukkonen, T.; Nicolino, M.; Tubiana-Rufi, N.; Klinkert, C.; Haberland, H.; Vazeou, A.; Madacsy, L.; Zangen, D.; Cherubini, V.; Rabbone, I.; Toni, S.; de Beaufort, C.; Waarde, W. Bakker-van; van den Berg, N.; Volkov, I.; Barrio, R.; Hanas, R.; Zumsteg, U.; Kuhlmann, B.; Aebi, C.; Schumacher, U.; Gschwend, S.; Hindmarsh, P.; Torres, M.; Shehadeh, N.; Phillip, M.

    2008-01-01

    Aims/hypothesis To assess the use of paediatric continuous subcutaneous infusion (CSII) under real-life conditions by analysing data recorded for up to 90 days and relating them to outcome. Methods Pump programming data from patients aged 0-18 years treated with CSII in 30 centres from 16 European c

  11. Establishing glycaemic control with continuous subcutaneous insulin infusion in children and adolescents with type 1 diabetes : experience of the PedPump Study in 17 countries

    NARCIS (Netherlands)

    Danne, T.; Battelino, T.; Jarosz-Chobot, P.; Kordonouri, O.; Pankowska, E.; Ludvigsson, J.; Schober, E.; Kaprio, E.; Saukkonen, T.; Nicolino, M.; Tubiana-Rufi, N.; Klinkert, C.; Haberland, H.; Vazeou, A.; Madacsy, L.; Zangen, D.; Cherubini, V.; Rabbone, I.; Toni, S.; de Beaufort, C.; Waarde, W. Bakker-van; van den Berg, N.; Volkov, I.; Barrio, R.; Hanas, R.; Zumsteg, U.; Kuhlmann, B.; Aebi, C.; Schumacher, U.; Gschwend, S.; Hindmarsh, P.; Torres, M.; Shehadeh, N.; Phillip, M.

    Aims/hypothesis To assess the use of paediatric continuous subcutaneous infusion (CSII) under real-life conditions by analysing data recorded for up to 90 days and relating them to outcome. Methods Pump programming data from patients aged 0-18 years treated with CSII in 30 centres from 16 European

  12. Insulin Analogs Applied with Continuous Subcutaneous Insulin Infusion (Pump in the Treatment of Diabetes

    Directory of Open Access Journals (Sweden)

    Ercan Tuncel

    2015-03-01

    Full Text Available Diabetes mellitus (DM is an important health problem that should be treated efficiently because of its high prevalence and high morbidity and mortality due to its complications. In patients with DM, the application of a treatment which provides physiologic insulin secretion as such in healthy individuals is directly related with the prevention of diabetes complications. Insulin analogs, which were developed in recent years and shown to have pharmacokinetic and pharmacodynamic superiority to human insulin, have made it possible to obtain natural insulin pattern in the body. In addition to development of insulin analogs, introduction of insulin application method of “continuous subcutaneous insulin infusion” (insulin pump has led a new era in the treatment of DM. In this review, treatment of type 1 and 2 DM patients with insulin analogs, particularly insulin aspart, applied with insulin pump was discussed in the light of the current literature.

  13. Use of continuous subcutaneous insulin infusion by a portable insulin pump during pregnancy in women with type 1 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Zorić Svetlana

    2006-01-01

    Full Text Available Background/aim: Diabetes mellitus is associated with an increased risk for neonatal morbidity and mortality. One of the most important goals in treating pregnancies complicated with diabetes is keeping glucose level within the normal range, especially in the first trimester. A portable insulin pump for continuous subcutaneous insulin infusion (CSII represents the best form of therapy for patients with type 1 diabetes mellitus during pregnancy. The aim of our study was to evaluate the effects of therapy with a portable insulin pump for continuous subcutaneous insulin infusion during the first trimester of pregnancy on the quality of glycoregulation and pregnancy outcome in women with type 1 diabetes mellitus. Methods. A total of 17 newly diagnosed pregnant women with type 1 diabetes mellitus were treated with CSII therapy for three months. The parameters of glycoregulation (hemoglobin A, glycosylated - HbA1c, mean blood glucose value in daily profiles - MBG, daily requirement for insulin - IJ/kg BM, lipid levels, blood pressure and renal function were estimated before and after the therapy. These parameters were correlated with parameters of pregnancy outcome: fetal weight, APGAR score, duration of pregnancy. Results. There was a significant improvement in HbA1c (8.94±1.62 vs. 6.90±1.22 %, p < 0.05, MBG (9.23±2.22 vs. 6.41±1.72 mmol/l, p < 0.01, and daily requirement for insulin (0.66±0.22 vs. 0.55±0.13 IJ/kg BM, p < 0.05 during the CSII therapy. There were significant correlations between fetal weight and HbA1c (r = -0.60, p < 0.05, triglyceride levels (r = −0.63, p < 0.01, and the number of pregnancies (r = −0.62, p < 0.01, as well as between APGAR score and MBG (r = −0.52, p < 0.05 and cholesterol levels (r = −0.65, p < 0,01 before a portable insulin pump was applicated. Conclusions. There was a significant improvement in the quality of glycoregulation during CSII therapy in the pregnant women with type 1 diabetes mellitus. The

  14. Continuous Subcutaneous Insulin Infusion (CSII) Pumps for Type 1 and Type 2 Adult Diabetic Populations: An Evidence-Based Analysis.

    Science.gov (United States)

    2009-01-01

    In June 2008, the Medical Advisory Secretariat began work on the Diabetes Strategy Evidence Project, an evidence-based review of the literature surrounding strategies for successful management and treatment of diabetes. This project came about when the Health System Strategy Division at the Ministry of Health and Long-Term Care subsequently asked the secretariat to provide an evidentiary platform for the Ministry's newly released Diabetes Strategy.After an initial review of the strategy and consultation with experts, the secretariat identified five key areas in which evidence was needed. Evidence-based analyses have been prepared for each of these five areas: insulin pumps, behavioural interventions, bariatric surgery, home telemonitoring, and community based care. For each area, an economic analysis was completed where appropriate and is described in a separate report.To review these titles within the Diabetes Strategy Evidence series, please visit the Medical Advisory Secretariat Web site, http://www.health.gov.on.ca/english/providers/program/mas/mas_about.html,DIABETES STRATEGY EVIDENCE PLATFORM: Summary of Evidence-Based AnalysesContinuous Subcutaneous Insulin Infusion Pumps for Type 1 and Type 2 Adult Diabetics: An Evidence-Based AnalysisBehavioural Interventions for Type 2 Diabetes: An Evidence-Based AnalysisBARIATRIC SURGERY FOR PEOPLE WITH DIABETES AND MORBID OBESITY: An Evidence-Based SummaryCommunity-Based Care for the Management of Type 2 Diabetes: An Evidence-Based AnalysisHome Telemonitoring for Type 2 Diabetes: An Evidence-Based AnalysisApplication of the Ontario Diabetes Economic Model (ODEM) to Determine the Cost-effectiveness and Budget Impact of Selected Type 2 Diabetes Interventions in Ontario The objective of this analysis is to review the efficacy of continuous subcutaneous insulin infusion (CSII) pumps as compared to multiple daily injections (MDI) for the type 1 and type 2 adult diabetics. Insulin therapy is an integral component of the

  15. Evaluation of a totally implanted venous access port and portable pump in a continuous chemotherapy infusion schedule on an outpatient basis.

    Science.gov (United States)

    Greidanus, J; de Vries, E G; Nieweg, M B; de Langen, Z J; Willemse, P H

    1987-11-01

    In this study we evaluated the feasibility of a totally implanted vascular access port (VAP) and portable infusion pump for cytostatic drug administration on an outpatient basis, in a 21-day continuous infusion schedule with 4-epidoxorubicin (phase I and phase II study) and mitoxantrone (phase I study). Patients were instructed to dissolve their own drugs at home. Fifty patients were treated with 114 cycles (2394 infusion days). The complication rate was low. In one patient thrombosis of the subclavian and superior caval vein resulted in the termination of treatment. One patient developed pulmonary embolism during treatment. Needle dislocation was observed in two patients. No septicaemia and no irreversible catheter occlusion were seen. Pump functioning was efficient and pump arrest (9 X) never lasted longer than 24 h. We conclude that a VAP and portable pump are a safe and reliable route of administration for cytostatic drugs on an outpatient basis and that patients are capable of preparing their own drugs at home without increase of complications.

  16. A web-based study of the relationship of duration of insulin pump infusion set use and fasting blood glucose level in adults with type 1 diabetes.

    Science.gov (United States)

    Sampson Perrin, Alysa J; Guzzetta, Russell C; Miller, Kellee M; Foster, Nicole C; Lee, Anna; Lee, Joyce M; Block, Jennifer M; Beck, Roy W

    2015-05-01

    To evaluate the impact of infusion set use duration on glycemic control, we conducted an Internet-based study using the T1D Exchange's online patient community, Glu ( myGlu.org ). For 14 days, 243 electronically consented adults with type 1 diabetes (T1D) entered online that day's fasting blood glucose (FBG) level, the prior day's total daily insulin (TDI) dose, and whether the infusion set was changed. Mean duration of infusion set use was 3.0 days. Mean FBG level was higher with each successive day of infusion set use, increasing from 126 mg/dL on Day 1 to 133 mg/dL on Day 3 to 147 mg/dL on Day 5 (P<0.001). TDI dose did not vary with increased duration of infusion set use. Internet-based data collection was used to rapidly conduct the study at low cost. The results indicate that FBG levels increase with each additional day of insulin pump infusion set use.

  17. 电脑输液泵控制鼻饲滴速的临床研究%Clinical research in controlling infusion rate during nasal feeding by infusion pump

    Institute of Scientific and Technical Information of China (English)

    严英; 刘玲

    2010-01-01

    目的 研究改进鼻饲的方法,减少腹泻、呕吐等并发症的发生.方法 选择重型颅脑外伤昏迷患者140例,按采用的鼻饲法分为对照组50例,实验组90例.对照组采用传统的鼻饲方法,实验组应用电脑输液泵控制鼻饲滴速,比较2组并发症的发生率.将实验组患者随机分为3组各30例,在营养液及总量相同的情况下,分别维持10,16,18 h,观察各时间段并发症发生率.结果 实验组腹泻、呕吐等并发症的发生率显著低于对照组;实验组在3个时间段中腹泻、呕吐等并发症的发生率比较无明显差异.结论 使用电脑输液泵控制鼻饲滴速,可明显降低腹泻、呕吐等并发症的发生率;鼻饲营养液在电脑输液泵控制下不必维持很长时间.%Objective To investigate and improve the methods of nasal feeding to reduce the occurrence of complication such as diarrhea and vomiting.Methods We separated 140 patients with heavy craniocerebral injury into the control group (50 patients) and the experimental group (90 patients) according to different nasal feeding methods. For the control group traditional method was used. For the experimental group infusion pump was used to control infusion rate. The incidence of complication was compared between two groups. And within experimental group, the same nutrient solutions in respect of type and volume were infused during 10 hours, 16 hours, and 18 hours respectively. The relationship between infusion rate and the occurrence of complication was observed, analyzed and compared to seek for the most suitable enteral nutrition route which incurred the least complication.Results The incidence of diarrhea and vomiting in the experimental group was lower than that of the control group. And there were no significant differences in the occurrence of complication by using infusion pump at three different infusion rates within the experimental group. Conclusions The application of infusion pump in nasal feeding

  18. Comparison of Insulin Pump Therapy (Continuous Subcutaneous Insulin Infusion) to Alternative Methods for Perioperative Glycemic Management in Patients with Planned Postoperative Admissions

    Science.gov (United States)

    Corney, Sarah M.; Dukatz, Tamra; Rosenblatt, Solomon; Harrison, Barbara; Murray, Robert; Sakharova, Alla; Balasubramaniam, Mamtha

    2012-01-01

    Background Patients with diabetes who use insulin pumps [continuous subcutaneous insulin infusion (CSII)] undergo surgeries that require postoperative hospital admission. There are no defined guidelines for CSII perioperative use. Methods This retrospective single-institution study identified type 1 and type 2 diabetes subjects by electronically searching 2005–2010 anesthesia preoperative assessments for “pump.” Surgical cases (n = 92) were grouped according to intraoperative insulin delivery method: (a) CSII continuation of basal rate with/without correctional insulin bolus(es) (n = 53); (b) conversion to intravenous insulin infusion (n = 20); and (c) CSII suspension with/without correctional insulin bolus(es) (n = 19). These groups were compared on mean intraoperative blood glucose (BG) and category of most extreme intraoperative BG. Results Differences were found on baseline characteristics of diabetes duration (p = .010), anesthesia time (p = .011), proportions receiving general anesthesia (p = .013), and preoperative BG (p = .033). The conversion group had the longest diabetes duration and anesthesia time; it had a higher proportion of general anesthesia recipients and a higher mean preoperative BG than the continuation group. There was no significant difference in mean BG/surgical case between continuation (163.5 ± 58.5 mg/dl), conversion (152.3 ± 28.9 mg/dl), and suspension groups (188.3 ± 44.9 mg/dl; p = .128). The suspension group experienced a greater percentage of cases (84.2%) with one or more intraoperative BG > 179 mg/dl than continuation (45.3%) and conversion (40%) groups Figure 1 groupings (p = .034). Conclusions In this limited sample, preliminary findings are consistent with similar intraoperative glycemic control between CSII continuation and CSII conversion to intravenous insulin infusions. Continuous subcutaneous insulin infusion suspension had a greater rate of hyperglycemia. Preoperative differences between insulin delivery groups

  19. Application of implantable infusion pump in the treatment of lvier carcinoma%埋植式药泵在肝癌治疗中的应用

    Institute of Scientific and Technical Information of China (English)

    王家胜; 凡水田; 黄建宏; 李保家

    2001-01-01

    目的 探讨对不能切除的肝癌患者术中应用埋植式药泵治疗的临床意义。方法 对28例肝癌患者, 术中作肝动脉和门静脉插管并皮下埋植药泵, 术中、术后经药泵进行肝脏局部灌注化疗取得了较好的疗效。结果 本组治疗后有效率为64.2%, 其中生存时间小于6个月15例, 6~12个月10例, 12个月以上3例其中1例存活22个月以上。结论 肝动脉局部灌注化疗对不能手术切除的晚期肝癌, 作为治疗手段不失为一种有效的方法。%Objective To investigate the efficacy of implantable infusion pump in the treatment of un-resectable liver cancer. Methods Twenty-eight patients with liver cancer were subjected to the subcutaneous implantation of chemotherapy infusion pump into hepatic artery and portal vein during operation, and hepatic local perfusion chemotherapy via the pump was performed during and after operation. Results In this group, the total effective rate was 64.2%. The survival time was less than 6 months in 15 cases, 6 to 12 months in 10 cases and over 12 months in 3 cases. Conclusions The local infusion chemotherapy via hepatic artery and portal vein was an effective therapy for those who could not undergo the resection of advanced liver cancer.

  20. Assessment of the Value of the Clinical Application of Special Infusion Pump Pipe%专用输液泵管路临床应用价值的评估

    Institute of Scientific and Technical Information of China (English)

    邵蕾; 杨坤; 乐莹; 郑博

    2012-01-01

    The clinical application value of infusion pumps dedicated infusion device was evaluated through the comparison on the accuracy between dedicated and non-specific infusion devices. Experiments were conducted by using five test points each repeated three times to detecting accuracy of the infusion of the three kinds of infusion devices. Through the analysis of test results, we found out that the infusion accuracy of special and non-dedicated infusion devices in the experiment, exists significant differences (P <0.05), and we believe that the use of infusion pumps dedicated infusion devicecan guarantees safety and reduces medical risks in clinical.%通过比较专用与非专用输液器对输液泵输液精度的影响,评估输液泵专用输液器的临床应用价值.实验采用五个测试点每点重复三次的方法对三种输液器的输液精度进行检测.通过对测试结果的分析,发现专用输液器与非专用输液器在实验中的输液精度存在显著的差异(P<0.05),认为使用输液泵专用输液器,能为临床输液治疗提供安全保障,降低医疗风险.

  1. Bomba de infusão de insulina em diabetes melito tipo 1 Insulin pump therapy in type 1 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Raphael Del Roio Liberatore Jr.

    2006-08-01

    Full Text Available OBJETIVO: Rever a experiência com a utilização da bomba de infusão de insulina em crianças e adolescentes, a fim de orientar o pediatra quanto às suas indicações e complicações. FONTE DOS DADOS : Foi realizada revisão sistemática de artigos publicados em literatura que abordassem a utilização da bomba de infusão de insulina, suas indicações, complicações e resposta ao tratamento. Dessa forma, todos os artigos publicados entre 1995 e 2005 foram resgatados através do levantamento em banco de dados MEDLINE e LILACS. As palavras-chave utilizadas foram: insulin pumps, type 1 diabetes mellitus e diabetes mellitus. Foram separados os artigos que, além disso, versassem sobre o assunto na faixa etária descrita SÍNTESE DOS DADOS: O uso da bomba de infusão de insulina em pacientes com diabetes melito tipo 1 não é uma necessidade para todos os pacientes, visto que, com tratamentos intensivos, os resultados conseguidos são muito parecidos, em termos de hemoglobina glicada e de controle de complicações a médio e longo prazo. No entanto, a bomba permite um maior conforto ao paciente, no sentido de que ele não precisa ficar tão restrito a horários rígidos de refeição e pode levar uma vida com melhor qualidade. Um primeiro requisito para quem pretenda usar a bomba é adaptar-se a aparelhos conectados ao corpo e a ter uma rotina de monitorização glicêmica rigorosa, pois, sem isso, as vantagens da bomba serão anuladas. As complicações, com os avanços tecnológicos de que dispomos atualmente, são muito infreqüentes. O custo, no entanto, é maior que nos tratamentos convencionais. CONCLUSÃO: Com a evolução das bombas de infusão e dos monitores de glicemia, incluindo sistemas de monitorização contínua, abre-se caminho para as "bombas inteligentes", e estaremos com um verdadeiro "pâncreas artificial", que pode mesmo ser implantado no paciente, permitindo uma vida com todas as regalias de uma pessoa não diab

  2. PUMPS

    Science.gov (United States)

    Thornton, J.D.

    1959-03-24

    A pump is described for conveving liquids, particure it is not advisable he apparatus. The to be submerged in the liquid to be pumped, a conduit extending from the high-velocity nozzle of the injector,and means for applying a pulsating prcesure to the surface of the liquid in the conduit, whereby the surface oscillates between positions in the conduit. During the positive half- cycle of an applied pulse liquid is forced through the high velocity nozzle or jet of the injector and operates in the manner of the well known water injector and pumps liquid from the main intake to the outlet of the injector. During the negative half-cycle of the pulse liquid flows in reverse through the jet but no reverse pumping action takes place.

  3. Usability Evaluation of Infusion Pump Based on System Usability Scale%基于系统可用性量表的输液泵可用性评估

    Institute of Scientific and Technical Information of China (English)

    严毅; 王国宏; 刘胜林; 吴汉曦; 张强

    2012-01-01

    Objective To evaluate the usability of 3 kinds of infusion pumps in clinical. Methods System usability scale(SUS) is used to investigate the usability evaluation of clinical nurses to infusion pumps. Results There is a significant statistical difference about usability among 3 kinds of infusion pumps. The usability of brand 1 is better than the other two. No significant statistical difference of usability is found between brand 2 and 3. Conclusion SUS is useful and efficient for evaluating the usability of infusion pumps.%目的 评估三款输液泵的临床可用性.方法 采用系统可用性量表(SUS),调查临床护士对输液泵的使用评价.结果 三种输液泵可用性具有差异(P<0.05),品牌1可用性优于品牌2与品牌3,品牌2与品牌3可用性无明显差异.结论 SUS可以有效地用于输液泵的临床可用性评估中.

  4. Skin regeneration in deep second-degree scald injuries either by infusion pumping or topical application of recombinant human erythropoietin gel

    Directory of Open Access Journals (Sweden)

    Giri P

    2015-05-01

    Full Text Available Priya Giri,1 Sabine Ebert,1 Ulf-Dietrich Braumann,2 Mathias Kremer,3 Shibashish Giri,1 Hans-Günther Machens,4 Augustinus Bader1 1Department of Cell Techniques and Applied Stem Cell Biology, Center for Biotechnology and Biomedicine (BBZ, Faculty of Medicine, University of Leipzig, Leipzig, Germany; 2Interdisciplinary Center for Bioinformatics (IZBI, University of Leipzig, Leipzig, Germany; 3Department of Plastic and Hand Surgery, University of Lübeck, Lübeck, Germany; 4Department of Plastic and Hand Surgery, Technical University of Munich, Munich, Germany Abstract: Large doses of recombinant growth factors formulated in solution form directly injected into the body is usual clinical practice in treating second-degree scald injuries, with promising results, but this approach creates side effects; furthermore, it may not allow appropriate levels of the factor to be sensed by the target injured tissue/organ in the specific time frame, owing to complications arising from regeneration. In this research, two delivery methods (infusion pumping and local topical application were applied to deliver recombinant human erythropoietin (rHuEPO for skin regeneration. First, rHuEPO was given in deep second-degree scald injury sites in mice by infusion pump. Vascularization was remarkably higher in the rHuEPO pumping group than in controls. Second, local topical application of rHuEPO gel was given in deep second-degree scald injury sites in rats. Histological analysis showed that epithelialization rate was significantly higher in the rHuEPO gel-treated group than in controls. Immunohistochemical studies showed that the rHuEPO gel-treated group showed remarkably higher expression of skin regeneration makers than the control group. An accurate method for visualization and quantification of blood vessel networks in target areas has still not been developed up to this point, because of technical difficulties in detecting such thin blood vessels. A method which

  5. 豚鼠耳蜗微渗透压泵慢性灌注技术的改进%Technical improvement of chronic infusion of drugs intothe guinea pig cocMea by an osmotic pump

    Institute of Scientific and Technical Information of China (English)

    杨卫平; 胡博华; 王佩英; 郭维; 姜泗长

    2001-01-01

    Objeetive:To introduce an improved technique of chronic infusion of drugs into the guinea pig cochlea using an osmotic pump. Methods: A stainless steel tube was surgically implanted into the basal turn of the guinea pig cochlea and connected to the pump. Artificial perilymphatic fluid was infused into the cochlea. Auditory brainstem responses (ABRs) and hair cell morphology were examined. Results:In eight artificial perilymphatic fluid infused cochleas, the thresholds of ABRs were kept in the normal level and no hair cell loss was found 14 days after the beginning of infusion.Conclusion:This result indicates that the improved technique perfects the method of osmotic pump implant for chronic infusion of drugs into the inner ear.%目的:介绍应用改进的微渗透压泵进行豚鼠耳蜗慢性灌注的方法。方法:将徽渗透压泵埋置于8只豚鼠背部,经固定于耳蜗底回鼓阶内的改良微导管将人工外淋巴液缓慢注入内耳,观察豚鼠耳蜗对徽渗透压泵慢性灌注人工外淋巴液的反应。结果:动物术后M d脑干诱发电反应阈值(ABR)无明显的变化,耳蜗螺旋神经节细胞及毛细胞未见损伤。结论:改进后的微渗透压泵耳蜗灌流技术完善了内耳慢性给药的实验方法。

  6. Adjustment of alarm of threshold value of Smith micro-medicinal infusion pump%史密斯注射泵高低阻塞报警的调整

    Institute of Scientific and Technical Information of China (English)

    张敏刚; 云庆辉

    2012-01-01

    目的:通过改变微量注射泵的阻塞报警阈值,确保临床微量注射用药的安全。方法:通过分析微量注射泵的设计得到产生阻塞报警的原理,对于不同类型的微量注射泵应用不同的调试方法,改变影响报警阈值的因素,达到改变报警阈值的目的;结果:经设备剂量检测调试后的微量注射泵95%能达到规定的安全值,极少数微量注射泵需进行不同的处理,以满足临床应用安全。结论:改变注射泵的报警影响因素可以达到改变报警阈值的目的。%Objective: To ensure the safety of the rational drug use, to change the threshold value of the micro-medicinal infusion pump. Methods: Through analyzing the principle of the micro-medicinal infusion pump produces stress, for the different type of the pump use different modify way, find the reasons of produces stress and change threshold value; Results: through change 95% the pump limens can return normal value, the others need next treat, meet clinic require. Conclusions: To change the reasons of create warning to change threshold value of micro-medicinal infusion pump.

  7. Comparison and Discussion of Velocity Accuracy of the Multi-Functional Micro Syringe Pump and Micro Infusion Pump%多功能微量注药泵与微量输液泵的流速精度对比与探讨

    Institute of Scientific and Technical Information of China (English)

    柏正璐; 张华伟; 蒋红兵

    2016-01-01

    目的:检测多功能微量注药泵和微量输液泵的流速精度,分析多功能微量注药泵的优缺点。方法采用Fluke质控设备对多功能微量注药泵和微量输液泵的流速精度进行检测,对实测数据进行分析与讨论。结果这两种微量泵的流速精度检测均在误差范围之内,同时多功能微量注药泵具有流速精度高的特点,并且消除了输液过程中滴漏和回血的可能。结论多功能微量注药泵能够实现一机多用,适用于不同科室,且轻便易携,从而可提高医疗单位的设备利用率,降低医疗成本。%Objective To test the velocity accuracy of the multi-functional micro syringe pump and common micro infusion pump so as to analyze the advantages and disadvantages of the multi-function syringe pump. Methods Fluke professional quality control equipment was used to test the velocity accuracy of the multi-functional micro syringe pump and micro infusion pump. Then, analysis and discussion of the data measured were made. Results The velocity accuracy of both the multi-functional micro syringe pump and common micro infusion pump were within the error range. The multi-functional micro syringe pump was possessed of high velocity accuracy, which eliminated the possibilities of dripping and blood returning in the infusion process. Conclusion The multi-functional micro syringe pump made it possible to apply this all-in-one and portable machine in different departments, which improved the medical equipment utilization and reduced the health-care costs.

  8. Infusion Extractor

    Science.gov (United States)

    Chang-Diaz, Franklin R.

    1988-01-01

    Apparatus and method of removing desirable constituents from an infusible material by infusion extraction, where a piston operating in a first chamber draws a solvent into the first chamber where it may be heated, and then moves the heated solvent into a second chamber containing the infusible material, and where infusion extraction takes place. The piston then moves the solvent containing the extract through a filter into the first chamber, leaving the extraction residue in the second chamber.

  9. 输液泵控制换血术治疗新生儿重症黄疸的护理研究%Nursing of Infusion Pump Control Transfusion in Treating Severe Neonatal Jaundice

    Institute of Scientific and Technical Information of China (English)

    耿洪维

    2016-01-01

    目的:探讨输液泵控制换血术治疗新生儿重症黄疸的护理效果。方法将68例新生儿重症黄疸患儿随机分为对照组和研究组,各34例,两组均接受输液泵控制换血术治疗,对照组应用常规护理,研究组应用综合护理,比较两组护理效果。结果两组患者临床治疗护理效果比较,研究组高于对照组,差异具有统计学意义(P<0.05)。结论应用输液泵控制换血术治疗新生儿重症黄疸能够取得显著的效果,配合综合护理有助于提高治疗效果。%Objective To investigate the nursing effect of infusion pump controlled exchange transfusion for treatment of neonatal severe jaundice. Methods 68 cases of neonatal severe jaundice patients were randomly assigned to study group and control group, 34 cases in each group, two groups underwent infusion pump control exchange transfusion for treatment, the control group used routine nursing, the research group was treated with comprehensive nursing, compared two groups of nursing effect. Results Two groups of patients with clinical treatment effect comparison, the study group was significantly higher than the control group, the difference was statistically significant (P<0.05).Conclusion By infusion pump control exchange transfusion in treating severe neonatal jaundice can achieve significant results, with comprehensive nursing is helpful to improve the therapeutic effect.

  10. Volumetric Virtual Environments

    Institute of Scientific and Technical Information of China (English)

    HE Taosong

    2000-01-01

    Driven by fast development of both virtual reality and volume visualization, we discuss some critical techniques towards building a volumetric VR system, specifically the modeling, rendering, and manipulations of a volumetric scene.Techniques such as voxel-based object simplification, accelerated volume rendering,fast stereo volume rendering, and volumetric "collision detection" are introduced and improved, with the idea of demonstrating the possibilities and potential benefits of incorporating volumetric models into VR systems.

  11. Precisión en flujo de infusión programado de bombas de nutrición enteral Precision in programmed infusion flow of enteral nutrition pumps

    Directory of Open Access Journals (Sweden)

    Juan Ignacio Padilla-Cuadra

    2008-09-01

    Full Text Available Justificación y objetivo: Se evaluó in vitro la precisión en el flujo de nutrición enteral en bombas peristálticas de nutrición enteral con el fin de determinar si ésta puede ser una variable que cause errores en la administración de la fórmula. Materiales y Métodos: Se evaluaron 13 bombas de infusión enteral del tipo peristáltico mediante la aplicación de un modelo de laboratorio que simulaba la administración a un paciente. Se usó para todos los casos una fórmula estándar diluida de la manera recomendada por el fabricante. Con un volumen meta de 240 mL. Se programó en cada bomba un flujo de infusión de 40 mL por hora. Para cada caso según el tiempo de infusión, se calculó el flujo de infusión real y a partir de la diferencia se calculó el porcentaje de error. Resultados: En 12 de las 13 bombas se detectó un error por exceso que fue de 7.5% hasta 52.5%. Solo una bomba, de marca distinta a todas las demás demostró un error de 0 mL/h con respecto a lo programado. Ninguna bomba mostró un déficit en el volumen de infusión. Conclusión: En la mayoría de las bombas evaluadas se detectó un porcentaje de error por exceso que supera lo estipulado por el fabricante.Justification and aim: To evaluate in vitro the accuracy of volume infusion of peristaltic enteral nutrition pumps to determine if this variable may be responsible for error’s in the administration of nutrition support. Materials and Methods: Thirteen pumps were evaluated through simulation using a model that resembles the administration of enteral nutrition to a patient. For every case, we used an standard formula diluted as recommended by the manufacturer. A volume of 240 mL was programmed to be infused at 40 ml per hour. For each case, time was measured until finishing the volume, comparing to the programmed time and calculating the delivery error. Results: In 12 of 13 pumps, we detected error by excess, which varied from 7.5% to 52.5%. Only one pump showed

  12. Numerical and clinical precision of continuous glucose monitoring in Colombian patients treated with insulin infusion pump with automated suspension in hypoglycemia.

    Science.gov (United States)

    Gómez, Ana M; Marín Sánchez, Alejandro; Muñoz, Oscar M; Colón Peña, Christian Alejandro

    2015-12-01

    Insulin pump therapy associated with continuous glucose monitoring has shown a positive clinical impact on diabetes control and reduction of hypoglycemia episodes. There are descriptions of the performance of this device in other populations, but its precision and accuracy in Colombia and Latin America are unknown, especially in the routine outpatient setting. Data from 33 type 1 and type 2 diabetes patients with sensor-augmented pump therapy with threshold suspend automation, MiniMed Paradigm® Veo™ (Medtronic, Northridge, California), managed at Hospital Universitario San Ignacio (Bogotá, Colombia) and receiving outpatient treatment, were analyzed. Simultaneous data from continuous glucose monitoring and capillary blood glucose were compared, and their precision and accuracy were calculating with different methods, including Clarke error grid. Analyses included 2,262 continuous glucose monitoring -reference paired glucose values. A mean absolute relative difference of 20.1% was found for all measurements, with a value higher than 23% for glucose levels ≤75mg/dL. Global compliance with the ISO criteria was 64.9%. It was higher for values >75mg/dl (68.3%, 1,308 of 1,916 readings), than for those ≤ 75mg/dl (49.4%, 171 of 346 readings). Clinical accuracy, as assessed by the Clarke error grid, showed that 91.77% of data were within the A and B zones (75.6% in hypoglycemia). A good numerical accuracy was found for continuous glucose monitoring in normo and hyperglycemia situations, with low precision in hypoglycemia. The clinical accuracy of the device was adequate, with no significant safety concerns for patients. Copyright © 2015 SEEN. Published by Elsevier España, S.L.U. All rights reserved.

  13. INFUSION LOUNGE

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Infusion Lounge——颇具亚洲风情的的夜店——坐落于旧金山市区大受追捧的联合广场之上,福森酒店之下。此夜店兼具了酒吧与餐厅的功能,它将提供加州与亚洲风味融为一体的佳肴及优雅的环境和一流的服务。Infusion Lounge不仅为旧金山当地,也将为整个行业重新定义高消费夜生活的概念。

  14. Increasing the volumetric efficiency of Diesel engines by intake pipes

    Science.gov (United States)

    List, Hans

    1933-01-01

    Development of a method for calculating the volumetric efficiency of piston engines with intake pipes. Application of this method to the scavenging pumps of two-stroke-cycle engines with crankcase scavenging and to four-stroke-cycle engines. The utility of the method is demonstrated by volumetric-efficiency tests of the two-stroke-cycle engines with crankcase scavenging. Its practical application to the calculation of intake pipes is illustrated by example.

  15. Clinical observation of continuously subcutaneous-pumped octreotide infusion in palliative treatment of malignant bowel obstruction%奥曲肽持续皮下泵入治疗恶性肠梗阻的临床观察

    Institute of Scientific and Technical Information of China (English)

    Dongfeng Yin; Yin Zhu; Yuqing Xing; Hong Gao; Yuzhen Pan; Lin Pan; Guangyi Tang; Xiangrong Xing; Lijiang Zhou

    2011-01-01

    objective: The aim of the study was to observe the effectiveness of continuously subcutaneous-pumped octreotide infusion in palliative treatment of malignant bowel obstruction (MBO). Methods: Clinical data were retrospectively analyzed in 26 carcinoma patients complicated with MBO, in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, China, from March 2007 to April 2009. All 26 carcinoma patients with MBO were divided into two groups: the controlling group (CG, routine therapy, 15 patients) and the octreotide group (OG, 11 patients). The octreotide group received routine therapy combined with octreotide (0.3 mg/d) by 24 hours continuously subcutaneous octreotide infusion. The changes of curative effectiveness related to symptoms, the times of recovering exsufflation and defecation, the average drain of gastrointestinal drainage tube, the duration of gastrointestinal drainage tube and the rate of extubation, were observed and compared between the two groups. Results: After treatment, remarkable changing rates of MBO related symptoms were 81.8%(9/11)in OG, and 46.7%(7/15) in CG(P<0.05). The 78% of SG and 30% of CG recovered the exsufflation and defecation, and the mean times they needed were 3.2 d and 5.8 d, respectively (P < 0.05). The durations of gastrointestinal drainage tube of OG and CG were (5 ± 1.2) d and (10 ± 2.3) d, respectively, and the rates of extubation were 54.5% and 20%, respectively. The improvement rate in the octreotide group was better than that in the controlling group and the difference was significant (72.7%and 26.7%, P < 0.05). Conclusion: The administration of octreotide in combination with routine treatment can be very effective in the treatment of MBO. It can relieve the symptoms of MBO effectively and improve the quality of life of the end-stage patients. It has provided one kind of new treating thought and method for treatment of malignant bowel obstruction.

  16. Volumetric composition of nanocomposites

    DEFF Research Database (Denmark)

    Madsen, Bo; Lilholt, Hans; Mannila, Juha

    2015-01-01

    Detailed characterisation of the properties of composite materials with nanoscale fibres is central for the further progress in optimization of their manufacturing and properties. In the present study, a methodology for the determination and analysis of the volumetric composition of nanocomposites...... is presented, using cellulose/epoxy and aluminosilicate/polylactate nanocomposites as case materials. The buoyancy method is used for the accurate measurements of materials density. The accuracy of the method is determined to be high, allowing the measured nanocomposite densities to be reported with 5...... significant figures. The plotting of the measured nanocomposite density as a function of the nanofibre weight content is shown to be a first good approach of assessing the porosity content of the materials. The known gravimetric composition of the nanocomposites is converted into a volumetric composition...

  17. Improved usability of a multi-infusion setup using a central control display

    NARCIS (Netherlands)

    Doesburg, Frank; Cnossen, Fokeltje; Dieperink, Willem; Bult, Wouter; Nijsten, Maarten W

    2016-01-01

    Infusion pumps are often associated with poor usability and an increased likelihood of medication errors [1]. Critically ill patients in the intensive care unit (ICU) usually receive multiple infusions simultaneously, which increases the likelihood of pump-related errors. Furthermore, the ICU is fre

  18. Clinical research of impulse GnRH infusion treatment to a patient with central secondary amenorrhea

    Institute of Scientific and Technical Information of China (English)

    孙首悦

    2014-01-01

    Objective To apply continuous subcutaneous pulse infusion of gonadotropin-releasing hormone(GnRH)to treat patients with central secondary amenorrhea,and to observe the induction of spontaneous ovulation and natural fertilization.Methods Using micro-pulse infusion pumps with each 90-minute infusion of LHRH 10μg daily,the serum LH,FSH,estrogen,and progesterone lev-

  19. Flexible Volumetric Structure

    Science.gov (United States)

    Cagle, Christopher M. (Inventor); Schlecht, Robin W. (Inventor)

    2014-01-01

    A flexible volumetric structure has a first spring that defines a three-dimensional volume and includes a serpentine structure elongatable and compressible along a length thereof. A second spring is coupled to at least one outboard edge region of the first spring. The second spring is a sheet-like structure capable of elongation along an in-plane dimension thereof. The second spring is oriented such that its in-plane dimension is aligned with the length of the first spring's serpentine structure.

  20. Method of infusion extraction

    Science.gov (United States)

    Chang-Diaz, Franklin R. (Inventor)

    1989-01-01

    Apparatus and method of removing desirable constituents from an infusible material by infusion extraction, where a piston operating in a first chamber draws a solvent into the first chamber where it may be heated, and then moves the heated solvent into a second chamber containing the infusible material, and where infusion extraction takes place. The piston then moves the solvent containing the extract through a filter into the first chamber, leaving the extraction residue in the second chamber.

  1. Leg edema from intrathecal opiate infusions.

    Science.gov (United States)

    Aldrete, J A; Couto da Silva JM

    2000-01-01

    Despite the increasing popularity of intrathecal infusions to treat patients with long-term non-cancer-related pain, this therapy is not without serious side-effects. Five out of 23 patients who had intrathecal infusions of opiates for longer than 24 months developed leg and feet edema. As predisposing factors, cardiovascular disease, deep venous thrombosis, peripheral vascular disease, and venous stasis of the lower extremities were considered. Every patient who developed pedal and leg edema after the implantation of an infusion pump was also found to have leg edema and venous stasis prior to the time when the pump was inserted. This complication was severe enough to limit their physical activity, and to produce lymphedema, ulcerations and hyperpigmentation of the skin. Reduction of the edema occurred when the dose of the opiate was decreased, and in two cases in which the infusion was discontinued, there was almost complete resolution of the syndrome. It appears that the pre-existence of pedal edema and of venous stasis is a relative contraindication to the long-term intrathecal infusion of opiates in patients with chronic non-cancer pain. Copyright 2000 European Federation of Chapters of the International Association for the Study of Pain.

  2. Malone-Brayton Cycle Engine/Heat Pump.

    Science.gov (United States)

    A machine, such as a heat pump , and having an all liquid heat exchange fluid, operates over a more nearly ideal thermodynamic cycle by adjustment of...difference in axial lengths of rotary pumps of the gear or vane type to achieve the adjustment of volumetric capacity. Adjustment of the heat pump system

  3. Impact of infusion method on amikacin serum levels in humans.

    Science.gov (United States)

    Simon, N; Décaudin, B; Lannoy, D; Odou, M F; De Broucker, M; Barthélémy, C; Poret, E; Dubreuil, L; Odou, P

    2010-08-01

    Aminoglycosides are broad-spectrum antibiotics with peak-dependent bactericidal activity, administered by gravity infusion or for more accuracy by electronic pump infusion. The aim of this study was to assess the difference between the two systems and its pharmacokinetic impact. Twenty-four patients hospitalised for community-acquired pulmonary infections received amikacin by IV route over 1 h with a targeted peak concentration of 35 mg/L. They were randomly distributed into two groups, one receiving infusion through a pump system, the other by gravity. Amikacin serum levels were determined at the end of infusion and 24 h later. C(max) values were significantly lower with gravity than pump (40.2 +/- 12.3 vs. 50.6 +/- 17.6 mg/L, respectively; p = 0.04). Elimination half-life time, volume of distribution and clearance did not differ significantly from one group to the other. The percentage of patients who failed to achieve the targeted peak concentration was significantly higher with gravity than pump (41.7% vs. 16.7%, respectively; p infusion flow-rate provides better control over amikacin C(max). This study underlines the fact that infusion device characteristics should be added to the physiopathological information of a patient if we are to make a better estimation of pharmacokinetic parameters.

  4. Quantitative Techniques in Volumetric Analysis

    Science.gov (United States)

    Zimmerman, John; Jacobsen, Jerrold J.

    1996-12-01

    Quantitative Techniques in Volumetric Analysis is a visual library of techniques used in making volumetric measurements. This 40-minute VHS videotape is designed as a resource for introducing students to proper volumetric methods and procedures. The entire tape, or relevant segments of the tape, can also be used to review procedures used in subsequent experiments that rely on the traditional art of quantitative analysis laboratory practice. The techniques included are: Quantitative transfer of a solid with a weighing spoon Quantitative transfer of a solid with a finger held weighing bottle Quantitative transfer of a solid with a paper strap held bottle Quantitative transfer of a solid with a spatula Examples of common quantitative weighing errors Quantitative transfer of a solid from dish to beaker to volumetric flask Quantitative transfer of a solid from dish to volumetric flask Volumetric transfer pipet A complete acid-base titration Hand technique variations The conventional view of contemporary quantitative chemical measurement tends to focus on instrumental systems, computers, and robotics. In this view, the analyst is relegated to placing standards and samples on a tray. A robotic arm delivers a sample to the analysis center, while a computer controls the analysis conditions and records the results. In spite of this, it is rare to find an analysis process that does not rely on some aspect of more traditional quantitative analysis techniques, such as careful dilution to the mark of a volumetric flask. Figure 2. Transfer of a solid with a spatula. Clearly, errors in a classical step will affect the quality of the final analysis. Because of this, it is still important for students to master the key elements of the traditional art of quantitative chemical analysis laboratory practice. Some aspects of chemical analysis, like careful rinsing to insure quantitative transfer, are often an automated part of an instrumental process that must be understood by the

  5. Test Facility for Volumetric Absorber

    Energy Technology Data Exchange (ETDEWEB)

    Ebert, M.; Dibowski, G.; Pfander, M.; Sack, J. P.; Schwarzbozl, P.; Ulmer, S.

    2006-07-01

    Long-time testing of volumetric absorber modules is an inevitable measure to gain the experience and reliability required for the commercialization of the open volumetric receiver technology. While solar tower test facilities are necessary for performance measurements of complete volumetric receivers, the long-term stability of individual components can be tested in less expensive test setups. For the qualification of the aging effects of operating cycles on single elements of new absorber materials and designs, a test facility was developed and constructed in the framework of the KOSMOSOL project. In order to provide the concentrated solar radiation level, the absorber test facility is integrated into a parabolic dish system at the Plataforma Solar de Almeria (PSA) in Spain. Several new designs of ceramic absorbers were developed and tested during the last months. (Author)

  6. Centrifugal pumps

    CERN Document Server

    Anderson, HH

    1981-01-01

    Centrifugal Pumps describes the whole range of the centrifugal pump (mixed flow and axial flow pumps are dealt with more briefly), with emphasis on the development of the boiler feed pump. Organized into 46 chapters, this book discusses the general hydrodynamic principles, performance, dimensions, type number, flow, and efficiency of centrifugal pumps. This text also explains the pumps performance; entry conditions and cavitation; speed and dimensions for a given duty; and losses. Some chapters further describe centrifugal pump mechanical design, installation, monitoring, and maintenance. The

  7. Continuous intraperitoneal insulin infusion in patients with 'brittle' diabetes

    DEFF Research Database (Denmark)

    DeVries, J H; Eskes, S A; Snoek, Frank J

    2002-01-01

    AIMS: To evaluate the effects of continuous intraperitoneal insulin infusion (CIPII) using implantable pumps on glycaemic control and duration of hospital stay in poorly controlled 'brittle' Dutch diabetes patients, and to assess their current quality of life. METHODS: Thirty-three patients were...

  8. Pumping life

    DEFF Research Database (Denmark)

    Sitsel, Oleg; Dach, Ingrid; Hoffmann, Robert Daniel

    2012-01-01

    of membrane proteins: P-type ATPase pumps. This article takes the reader on a tour from Aarhus to Copenhagen, from bacteria to plants and humans, and from ions over protein structures to diseases caused by malfunctioning pump proteins. The magazine Nature once titled work published from PUMPKIN ‘Pumping ions......’. Here we illustrate that the pumping of ions means nothing less than the pumping of life....

  9. The effect and nursing analysis of micro pump airway continuous infusion of asarone injection in the prevention of ventilator-associated pneumonia%微量泵持续气道滴注细辛脑注射液预防呼吸机相关性肺炎的效果及护理分析

    Institute of Scientific and Technical Information of China (English)

    蔡美容

    2013-01-01

    Objective To investigate the effect and nursing methods of micro pump airway continuous infusion of asarone injection in the prevention of ventilator-associated pneumonia (VAP).Methods A total of 66 patients with mechanical ventilation were divided into the observation group and the control group,the control group was used the traditional humidification fluid,the observation group was treated with micro pump continuous airway infusion of asarone injection; two groups were compared with airway humidification effect and the effects of mechanical ventilation.Results The irritating the phlegm scab formation,the number of times of sputum suction,heart rate,respiratory rate,C reactive protein,white blood cell count,neutrophil,body temperature,sputum culture in the observation group were significantly better than those in the control group (P < 0.05).And the incidence of VAP,partial pressure of oxygen,oxygen saturation,duration of hospitalization in the observation group were significantly better than those in the control group (P < 0.05).Conclusions Micro pump airway continuous infusion of asarone injection can effectively prevent the occurrence of VAP; Strengthen comprehensive nursing during the step of can improve the therapeutic effect.%目的 探讨微量泵持续气道滴注细辛脑注射液预防呼吸机相关性肺炎(VAP)的临床疗效及护理方法.方法 将66例机械通气的患者分为观察组和对照组,对照组采用传统湿化液,观察组采用微量泵持续气道滴细辛脑注射液,比较两组患者气道湿化的效果和机械通气的效果.结果 观察组的刺激性痰痂形成次数、吸痰次数、心率、呼吸频率、C反应蛋白、白细胞计数、中性粒细胞、体温、痰培养显著优于对照组(P<0.05),且观察组的VAP发生率、氧分压、血氧饱和度、住院时间显著优于对照组(P<0.05).结论 微量泵持续气道滴注细辛脑注射液可有效预防VAP的发生,期间加强综合护理可提高治疗效果.

  10. Intraperitoneal insulin infusion: on the way to the artificial pancreas

    Directory of Open Access Journals (Sweden)

    Vladimir Aleksandrovich Karpel'ev

    2015-06-01

    Full Text Available Creating an "artificial pancreas" (a "closed loop" insulin pump, with self-adjusting insulin abilities, based on real time continuous glucose monitoring data – is one of the most actual medical challenges of modern engineering and cybernetics.Artificial pancreas (AP prototypes based on wearable insulin pump with subcutaneous insulin delivery are still problematic, mainly because of slow insulin pharmacokinetics. Intravenous insulin infusion via AP allows effectively maintain euglycaemia for inpatients, due to insulin pharmacokinetics and pharmacodynamics advantages. Unfortunately, it can’t be used for outpatients. Intraperitoneal insulin infusion is still relatively infrequently used in the world, but it is a promising alternative, compared to both previous methods due to a physiological action profile, fast insulin pharmacokinetics, relatively better safety and availability for outpatient usage.The purpose of this review is to describe the intraperitoneal insulin infusion features for diabetes patients at a point of AP creation perspectives. 

  11. Vacuum infusion equipment design and the influence of reinforcement layers addition to the resin infusion time

    Science.gov (United States)

    Saputra, A. H.; Setyarso, G.

    2016-11-01

    The characteristic of composite material is greatly influenced by the manufacture method of composite. The conventional method that has been used such as hand lay-up and spray up are simple and easy to apply but the composite tend to have a void in it because of the air trapped during the manufacture process. Vacuum infusion is one of the modern composite manufacture process which can replace the conventional method. The problem of this method happens when the resin infusion time become longer due to the addition of reinforcement layers. When the resin infusion time is longer than the resin's gel time, the resin will become gel and not able to flow into the mold. In order to overcome this problem, a study that observe the influence of reinforcement layers addition to the resin infusion time is needed. In this study, vacuum infusion equipment for composite materials manufacturing process that are designed consists of: 1×1m glass as the mold, 1L PVC tube for the resin container, 1L glass tube for the resin trap, and ‘A HP vacuum pump with 7 CFM vacuum speed. The resin that is used in this study is unsaturated polyester resin (UPR) and the fiber used as reinforcement is fiber glass. It is observed that the more number of reinforcement layers the longer resin infusion time will be. The resin infusion time (in seconds) from two until six layers respectively for the area of 15×20cm are: 88, 115, 145, 174, 196; for the area of 15×25cm are: 119, 142, 168, 198, 235; and for the area of 15×35cm are: 181, 203, 235, 263, 303. The maximum reinforcement layers that can be accommodated for each 15×20cm, 15×25cm, and 15×35cm area are respectively 31 layers, 29 layers, and 25 layers.

  12. [Insulin pump therapy: for whom and why?].

    Science.gov (United States)

    Saraheimo, Markku; Honkasalo, Mikko; Miettinen, Marko

    2013-01-01

    Insulin pump therapy utilizes continuous infusion for the basic supply of insulin. As compared with multiple daily injections, pump therapy enables a clearly more precise targeting of the insulin therapy with respect to both time and quantity. This is important for insulin-sensitive patients such as small children, adults susceptible to hypoglycemia, or diabetics, whose blood glucose level exhibits a clear-cut elevation in the small hours (the dawn phenomenon). Also a diabetic with a high HbA1c and a good motivation for treatment may significantly benefit from the pump. Insulin pump therapy requires commitment to good self-monitoring from the diabetic patient.

  13. Magnetocaloric pump

    Science.gov (United States)

    Brown, G. V.

    1973-01-01

    Very cold liquids and gases such as helium, neon, and nitrogen can be pumped by using magnetocaloric effect. Adiabatic magnetization and demagnetization are used to alternately heat and cool slug of pumped fluid contained in closed chamber.

  14. Continuous intraperitoneal insulin infusion in the treatment of type 1 diabetes mellitus : glycaemia and beyond

    NARCIS (Netherlands)

    van Dijk, Peter R.

    2015-01-01

    Continuous intraperitoneal insulin infusion (CIPII) with an implantable pump is a last-resort treatment option for selected patients with type 1 diabetes mellitus (T1DM). As compared to the most commonly used forms of insulin administration -injections and an externally placed pump- which deliver in

  15. Continuous intraperitoneal insulin infusion in the treatment of type 1 diabetes mellitus : glycaemia and beyond

    NARCIS (Netherlands)

    van Dijk, Peter R.

    2015-01-01

    Continuous intraperitoneal insulin infusion (CIPII) with an implantable pump is a last-resort treatment option for selected patients with type 1 diabetes mellitus (T1DM). As compared to the most commonly used forms of insulin administration -injections and an externally placed pump- which deliver

  16. Heat pumps

    CERN Document Server

    Macmichael, DBA

    1988-01-01

    A fully revised and extended account of the design, manufacture and use of heat pumps in both industrial and domestic applications. Topics covered include a detailed description of the various heat pump cycles, the components of a heat pump system - drive, compressor, heat exchangers etc., and the more practical considerations to be taken into account in their selection.

  17. Molecular system generation with strong resonance optical pumping

    Energy Technology Data Exchange (ETDEWEB)

    Kuntsevich, B.F.; Churakov, V.V.

    1977-03-01

    A study was made of molecular system generation modulated by three oscillating levels with a rotating structure with strong resonance optical pumping. Molecular behavior of the active medium is described by equations for the density matrix. The relationship between the amplification coefficient and pressure at various pumping intensities was examined. In approaching the assigned pumping field, an examination was made of how the generation field is affected by the volumetric density of the pumping energy, partial pressure of the buffer gas and frequency difference in the pumping channel.

  18. Heat pumps

    CERN Document Server

    Brodowicz, Kazimierz; Wyszynski, M L; Wyszynski

    2013-01-01

    Heat pumps and related technology are in widespread use in industrial processes and installations. This book presents a unified, comprehensive and systematic treatment of the design and operation of both compression and sorption heat pumps. Heat pump thermodynamics, the choice of working fluid and the characteristics of low temperature heat sources and their application to heat pumps are covered in detail.Economic aspects are discussed and the extensive use of the exergy concept in evaluating performance of heat pumps is a unique feature of the book. The thermodynamic and chemical properties o

  19. A New Approach in the Design of High-Risk Infusion Technology

    Directory of Open Access Journals (Sweden)

    Robert Murphy

    2010-01-01

    Full Text Available The syringe infusion pump has been established as the instrument of choice for high-risk infusions, where potent drugs are often delivered at low rates of flow. However, numerous instances of unexpected flow error with consequent patient physiological impact have been reported. These include unwanted bolus delivery on release of line occlusion, dosage fluctuation due to pump height change and fluid reflux within the multiple pump installations now common in the Intensive Care Unit (ICU. This article examines the performance of a typical ICU syringe infusion pump and identifies mechanical compliance, inherent in commercial designs, as a source of flow error that should not be ignored by equipment designers. A prototype low compliance system is described and tested with performance compared to the conventional design, demonstrating advantages in terms of lower flow error.

  20. Volumetric Three-Dimensional Display Systems

    Science.gov (United States)

    Blundell, Barry G.; Schwarz, Adam J.

    2000-03-01

    A comprehensive study of approaches to three-dimensional visualization by volumetric display systems This groundbreaking volume provides an unbiased and in-depth discussion on a broad range of volumetric three-dimensional display systems. It examines the history, development, design, and future of these displays, and considers their potential for application to key areas in which visualization plays a major role. Drawing substantially on material that was previously unpublished or available only in patent form, the authors establish the first comprehensive technical and mathematical formalization of the field, and examine a number of different volumetric architectures. System level design strategies are presented, from which proposals for the next generation of high-definition predictable volumetric systems are developed. To ensure that researchers will benefit from work already completed, they provide: * Descriptions of several recent volumetric display systems prepared from material supplied by the teams that created them * An abstract volumetric display system design paradigm * An historical summary of 90 years of development in volumetric display system technology * An assessment of the strengths and weaknesses of many of the systems proposed to date * A unified presentation of the underlying principles of volumetric display systems * A comprehensive bibliography Beautifully supplemented with 17 color plates that illustrate volumetric images and prototype displays, Volumetric Three-Dimensional Display Systems is an indispensable resource for professionals in imaging systems development, scientific visualization, medical imaging, computer graphics, aerospace, military planning, and CAD/CAE.

  1. Clinical Informatics: Recursive Concurrence Intravenous Medication Administration Systems Protocols for Addressing the Potential Problem of Recessive Lethal Autonomy in Smart Infusion Systems

    OpenAIRE

    Nyagudi, Nyagudi Musandu

    2016-01-01

    Smart Infusion Pumps are vital tools for use in administering a broad range of parenteral/intravenous medications. Safe and effective use of smart infusion pumps depends upon their integration with Pump Servers, Computerized Physician Order Entry Systems, Pharmacy Information Systems, DERS/MERS Dose/Medication Error Reduction Systems( and the digital Drug Libraries that they use), eMARS/electronic Medication Administration Records Systems, etc. More computer systems result in more computer ne...

  2. Centrifugal pumps

    CERN Document Server

    Gülich, Johann Friedrich

    2014-01-01

    This book gives an unparalleled, up-to-date, in-depth treatment of all kinds of flow phenomena encountered in centrifugal pumps including the complex interactions of fluid flow with vibrations and wear of materials. The scope includes all aspects of hydraulic design, 3D-flow phenomena and partload operation, cavitation, numerical flow calculations, hydraulic forces, pressure pulsations, noise, pump vibrations (notably bearing housing vibration diagnostics and remedies), pipe vibrations, pump characteristics and pump operation, design of intake structures, the effects of highly viscous flows, pumping of gas-liquid mixtures, hydraulic transport of solids, fatigue damage to impellers or diffusers, material selection under the aspects of fatigue, corrosion, erosion-corrosion or hydro-abrasive wear, pump selection, and hydraulic quality criteria. As a novelty, the 3rd ed. brings a fully analytical design method for radial impellers, which eliminates the arbitrary choices inherent to former design procedures. The d...

  3. Ferroelectric Pump

    Science.gov (United States)

    Jalink, Antony, Jr. (Inventor); Hellbaum, Richard F. (Inventor); Rohrbach, Wayne W. (Inventor)

    2000-01-01

    A ferroelectric pump has one or more variable volume pumping chambers internal to a housing. Each chamber has at least one wall comprising a dome shaped internally prestressed ferroelectric actuator having a curvature and a dome height that varies with an electric voltage applied between an inside and outside surface of the actuator. A pumped medium flows into and out of each pumping chamber in response to displacement of the ferroelectric actuator. The ferroelectric actuator is mounted within each wall and isolates each ferroelectric actuator from the pumped medium, supplies a path for voltage to be applied to each ferroelectric actuator, and provides for positive containment of each ferroelectric actuator while allowing displacement of the entirety of each ferroelectric actuator in response to the applied voltage.

  4. A reduced volumetric expansion factor plot

    Science.gov (United States)

    Hendricks, R. C.

    1979-01-01

    A reduced volumetric expansion factor plot has been constructed for simple fluids which is suitable for engineering computations in heat transfer. Volumetric expansion factors have been found useful in correlating heat transfer data over a wide range of operating conditions including liquids, gases and the near critical region.

  5. [Continuous-infusion ketamine].

    Science.gov (United States)

    Mancini, P G; Caggese, G; Di Fabio, A; Di Nino, G F; Cocchi, V

    1980-08-01

    An investigation was made of the employment of ketamin as the sole anaesthetic in general surgery, using continuous infusion of a 1% solution for both induction and maintenance in 118 cases. ECG was monitored and arterial pressure was measured invasively. Central venous pressure was also determined in 10 cases. Changes in serum enzyme values during and after surgery were examined in 35 patients. Blood samples were withdrawn before induction, after the return to consciousness, and 24 hr after the operation. Side-effects were common, but slight. Five patients suffered from nightmares, but these were persons with marked imaginative activity and a melancholic nature. Cardiocirculatory function was satisfactory. In particular, peripheral perfusion was excellent in all cases.

  6. Effect of insulin pump infusion on comprehensive stress state of ...

    African Journals Online (AJOL)

    dioxide combining power (CO2-CP) and C-reactive peptide levels in the treatment group were higher (p. < 0.05) than ... hypoglycaemia, and slow negative conversion of ketone bodies .... synthesis of reactive oxygen intermediates, leading to ...

  7. Infusion's greenfield subsidiary in Poland

    NARCIS (Netherlands)

    Williams, C.; van Eerde, W.; The, D.

    2012-01-01

    The president of Infusion Development Corporation was reviewing the progress of the new subsidiary the company had set up 15 months earlier in Krakow, Poland. The purpose of the subsidiary was to work with other Infusion offices around the world to provide innovative software development services to

  8. Performance of a New Lightweight Reciprocating Pump

    Energy Technology Data Exchange (ETDEWEB)

    Whitehead, J C

    2005-06-09

    A new four-chamber piston pump design has been fabricated and tested. The small-scale propellant pump is intended to be powered by gas at elevated temperatures, e.g. in a gas-generator cycle rocket propulsion system. Two key features are combined for the first time: leak-tight liquid-cooled seals, and a high throughput per unit hardware mass. Measured performance curves quantify flows, pressures, leakage, volumetric efficiency, and tank pressure requirements. A pair of 300-gram pumps operating with significant margin could deliver fuel and oxidizer at 5 MPa to a compact lightweight 1000-N engine, while tank pressure remains at 0.35 MPa. Pump weight is well below one percent of thrust, as is typical for launch vehicle engines. Applications include small upper stages, aggressive maneuvers in space, and miniature launch vehicles for Mars ascent.

  9. Insulin Pump Malfunction During Hospitalization: Two Case Reports.

    Science.gov (United States)

    Faulds, Eileen R; Wyne, Kathleen L; Buschur, Elizabeth O; McDaniel, Jodi; Dungan, Kathleen

    2016-06-01

    Insulin pump malfunctions and failures continue to occur; however, more severe malfunctions such as the "runaway pump" phenomenon are rarely reported. This article describes two cases of pump malfunction in which pump users appear to have received an unsolicited bolus of insulin resulting in severe episodes of hypoglycemia during hospitalization. Both cases of insulin pump malfunction occurred in the inpatient setting at a large academic medical center in the United States. An analysis of the corresponding insulin pump downloads was performed. The Food and Drug Administration's (FDA's) Manufacturer and User Facility Device Experience (MAUDE) database was searched for similar cases involving Medtronic (Northridge, CA) insulin pumps using the terms "pump," "infusion," "insulin AND malfunction AND Medtronic." The two cases described show remarkable similarities, each demonstrating a severe hypoglycemic event preceded by an infusion site change followed by an alarm. In both cases a rapid spraying of insulin was reported. The insulin pump downloads validated much of the patients' and medical staff's descriptions of events. The FDA's MAUDE database search revealed 425 cases meeting our search term criteria. All cases were reviewed. Seven cases were identified involving independent movement of the reservoir piston. The cases detailed are the first to describe an insulin pump malfunction of this nature in the hospital setting involving unsolicited insulin boluses leading to severe hypoglycemia. The cases are particularly compelling in that they were witnessed by medical personnel. Providers and patients should receive instruction education on the recognition and management of insulin pump malfunction.

  10. Penis Pump

    Science.gov (United States)

    ... claim that they can be used to increase penis size, but there's no evidence that they work for ... circumstances, using a penis pump might help your penis maintain its natural size and shape after prostate surgery or if you ...

  11. Surfactant enhanced volumetric sweep efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Harwell, J.H.; Scamehorn, J.F.

    1989-10-01

    Surfactant-enhanced waterflooding is a novel EOR method aimed to improve the volumetric sweep efficiencies in reservoirs. The technique depends upon the ability to induce phase changes in surfactant solutions by mixing with surfactants of opposite charge or with salts of appropriate type. One surfactant or salt solution is injected into the reservoir. It is followed later by injection of another surfactant or salt solution. The sequence of injections is arranged so that the two solutions do not mix until they are into the permeable regions well away from the well bore. When they mix at this point, by design they form a precipitate or gel-like coacervate phase, plugging this permeable region, forcing flow through less permeable regions of the reservoir, improving sweep efficiency. The selectivity of the plugging process is demonstrated by achieving permeability reductions in the high permeable regions of Berea sandstone cores. Strategies were set to obtain a better control over the plug placement and the stability of plugs. A numerical simulator has been developed to investigate the potential increases in oil production of model systems. Furthermore, the hardness tolerance of anionic surfactant solutions is shown to be enhanced by addition of monovalent electrolyte or nonionic surfactants. 34 refs., 32 figs., 8 tabs.

  12. Adjacent central venous catheters can result in immediate aspiration of infused drugs during renal replacement therapy.

    Science.gov (United States)

    Kam, K Y R; Mari, J M; Wigmore, T J

    2012-02-01

    Dual-lumen haemodiafiltration catheters enable continuous renal replacement therapy in the critically ill and are often co-located with central venous catheters used to infuse drugs. The extent to which infusions are immediately aspirated by an adjacent haemodiafiltration catheter remains unknown. A bench model was constructed to evaluate this effect. A central venous catheter and a haemodiafiltration catheter were inserted into a simulated central vein and flow generated using centrifugal pumps within the simulated vein and haemodiafiltration circuit. Ink was used as a visual tracer and creatinine solution as a quantifiable tracer. Tracers were completely aspirated by the haemodiafiltration catheter unless the infusion was at least 1 cm downstream to the arterial port. No tracer was aspirated from catheters infusing at least 2 cm downstream. Orientation of side ports did not affect tracer elimination. Co-location of central venous and haemodiafiltration catheters may lead to complete aspiration of infusions into the haemodiafilter with resultant drug under-dosing.

  13. Continuous infusion of low-dose doxorubicin, epirubicin and mitoxantrone in cancer chemotherapy: a review.

    Science.gov (United States)

    Greidanus, J; Willemse, P H; Uges, D R; Oremus, E T; De Langen, Z J; De Vries, E G

    1988-12-09

    With the recent development of reliable portable pumps and safe venous access systems, continuous infusion of chemotherapeutic agents on an out-patient basis has become feasible. Advantages of continuous infusion are the long-term exposure of tumour cells to the drug and the fact that most toxic effects are reduced for doxorubicin, epirubicin and mitoxantrone due to elimination of the high peak plasma levels. Preliminary data for doxorubicin suggest that its antitumour activity is maintained. Pharmacokinetic studies with epirubicin and mitoxantrone showed a linear relationship between drug dose infused and the steady-state plasma level for these drugs. The area under the curve for leukocytes drug level was higher during continuous infusion than after an equitoxic bolus injection of epirubicin and mitoxantrone. Well-randomized clinical trials will be necessary to investigate the role of continuous infusion of antracyclines and mitoxantrone in cancer chemotherapy in the future.

  14. Experimental Study of Air-Lift Pumps Characteristics

    Directory of Open Access Journals (Sweden)

    Naji F. Al-Saqer

    2014-03-01

    Full Text Available The mean aim of this work is to study the Air-lift pumps characteristics according to design parameters such as the percentage of the distance between throat section and nozzle and the driving air pressure, suction head and also study the effect of each parameter on the air lift pump characteristics in order to have a better performance of such pump under various conditions. A certain geometry for air-lift pump designed and manufactured. The experiments show that there must be careful in increasing the suction head, and a balance must be considered between the suction head and the driving air volumetric flow rate. While the effect of increasing air pressure will stop at certain maximum of the ratio of the volumetric flow rate of water and air that is any increase in air pressure will meet no change ratio of the volumetric flow rate of water and air, While Increasing S/Dth will leads to decrease in the percentage of ratio of the volumetric flow rate of water and air because the optimum S/Dth so that at this value we will have the best performance and any other values for S/Dth the percentage of ratio of the volumetric flow rate of water and air will decreases , but this effect is not so clear and it could be neglected. The pump performance is not so sensitive with the change of S/Dth after a certain value, this information will help in the use of the air-lift pump in several applications using the predetermined operating conditions.

  15. Perioperative hepatocyte growth factor (HGF) infusions improve hepatic regeneration following portal branch ligation (PBL) in rodents.

    Science.gov (United States)

    Mangieri, Christopher W; McCartt, Jason C; Strode, Matthew A; Lowry, John E; Balakrishna, Prasad M

    2017-07-01

    As hepatic surgery has become safer and more commonly performed, the extent of hepatic resections has increased. When there is not enough expected hepatic reserve to facilitate primary resection of hepatic tumors, a clinical adjunct to facilitating primary resection is portal vein embolization (PVE). PVE allows the hepatic remnant to increase to an appropriate size prior to resection via hepatocyte regeneration; however, PVE is not always successful in facilitating adequate regeneration. One of the strongest trophic factors for hepatocyte regeneration is hepatocyte growth factor (HGF). The purpose of this study was to improve hepatic regeneration with perioperative HGF infusions in an animal model that mimics PVE. Portal branch ligation (PBL) in rodents is equivalent to PVE in humans. We performed left-sided PBL in Sprague-Dawley rodents with the experimental group receiving perioperative HGF infusions. Baseline and postoperative liver volumetrics were obtained with CT scanning methods as performed in clinical practice. Baseline and postoperative liver functions were assessed via indocyanine green (ICG) elimination testing. HGF infused rodents had statistically significant increase in all postoperative liver volumetrics. Most clinically relevant were increased right liver volumes (RLV), 14.10 versus 7.85 cm(3) (p value 0.0001), and increased degree of hypertrophy (DH %), 159.23 versus 47.11 % (p value 0.0079). HGF infused rodents also had a quick return to baseline liver function, 2.38 days compared to 6.13 days (p value 0.0001). Perioperative HGF infusions significantly increase hepatic regeneration following PBL in rodents. Perioperative HGF infusions following PVE are a possible adjunct to increase the amount of patients able to successfully undergo primary resection for hepatic tumors. Further basic science is warranted in examining the use of HGF infusions to increase hepatic regeneration and translating that basic science work to clinical practice.

  16. Laser Based 3D Volumetric Display System

    Science.gov (United States)

    1993-03-01

    Literature, Costa Mesa, CA July 1983. 3. "A Real Time Autostereoscopic Multiplanar 3D Display System", Rodney Don Williams, Felix Garcia, Jr., Texas...8217 .- NUMBERS LASER BASED 3D VOLUMETRIC DISPLAY SYSTEM PR: CD13 0. AUTHOR(S) PE: N/AWIU: DN303151 P. Soltan, J. Trias, W. Robinson, W. Dahlke 7...laser generated 3D volumetric images on a rotating double helix, (where the 3D displays are computer controlled for group viewing with the naked eye

  17. Prolonged fever after Infliximab infusion

    Institute of Scientific and Technical Information of China (English)

    Jennifer; Katz; Michael; Frank

    2012-01-01

    Pharmacologic management for ulcerative colitis (UC) has recently been expanded to include antitumor necrosis factor (TNF) therapy for severe disease. Infliximab, a chimeric monoclonal antibody directed again TNF α was first tested in patients with Crohn’s disease. In addition to serious infections, malignancy, drug induced lupus and other autoimmune diseases, serum sickness-like reactions, neurological disease, and infusion reactions further complicate the use of Infliximab. We report a case of prolonged fever after Infliximab infusion to treat steroid refractory UC.

  18. Implementation and optimization of smart infusion systems: are we reaping the safety benefits?

    Science.gov (United States)

    Trbovich, Patricia L; Cafazzo, Joseph A; Easty, Anthony C

    2013-01-01

    To address the high incidence of infusion errors, manufacturers have replaced the development of standard infusion pumps with smart pump systems. The implementation and ongoing optimization processes for smart pumps are more complex, as they require larger coordinated efforts with stakeholders throughout the medication process. If improper implementation/optimization processes are followed, hospitals invest in this technology while extracting minimal benefit. We assessed the processes hospitals employed when migrating from standard to smart infusion systems, and the extent to which they leveraged their investments from both a systems and resource perspective. Twenty-nine hospitals in Ontario, Canada, were surveyed that had either implemented smart pump systems or were in the process of implementing, representing a response rate of 69%. Results demonstrated that hospitals purchased smart pumps for reasons other than safety, did not involve a multidisciplinary team during implementation, made little effort to standardize drug concentrations or develop drug libraries and dosing limits, seldom monitored how nurses use the pumps, and failed to ensure wireless connectivity to upgrade protocols and download use data. Consequently, they are failing to realize the safety benefits these systems can provide.

  19. Review of pharmacokinetic models for target controlled infusions in anesthesia

    Directory of Open Access Journals (Sweden)

    Subash Kennedy Sivasubramaniam

    2014-06-01

    Full Text Available Intravenous injection of anesthetic drugs dates back to the 17th Century when opium and chloral hydrate have been injected intravenously. It was not until the 1930s intravenous anesthesia became popular with the invention of barbiturates.Early intravenous anesthetic agents such as barbiturates were ideal for induction of anesthesia, but not suitable for maintenance of anesthesia. Most of these drugs accumulated significantly with increasing durations of infusion and also resulted in cardiorespiratory depression. The invention of propofol and shorter acting opioid analgesics such as remifentanil and alfentanil have revolutionized intravenous anesthesia. The rapid onset and offset of these drugs lends itself to being suitable agents for maintenance of anesthesia over prolonged periods of time. Detailed understanding of the pharmacokinetics of propofol and remifentanil, combined with technological advances in intravenous pumps capable of accurate delivery of drugs have resulted in great development of the field of total intravenous anesthesia and target controlled infusions. I would like to discuss, in this article, the pharmacokinetics and pharmacokinetic models behind these intravenous infusion pumps. [Int J Basic Clin Pharmacol 2014; 3(3.000: 417-423

  20. Retinal characteristics during 1 year of insulin pump therapy in type 1 diabetes

    DEFF Research Database (Denmark)

    Klefter, Oliver Niels; Hommel, Eva; Munch, Inger Christine;

    2016-01-01

    PURPOSE: To investigate changes in retinal metabolism, function, structure and morphology in relation to initiation of insulin pump therapy (continuous subcutaneous insulin infusion, CSII). METHODS: Visual acuity, retinopathy level, dark adaptation kinetics, retinal and subfoveal choroidal thickn...

  1. Insulin pump (dose-to-dose) accuracy: what does it mean and when is it important?

    Science.gov (United States)

    Zisser, Howard

    2014-11-01

    This article reviews the concept of using the proper methods for the proper task, in this case measuring dose-to-dose accuracy of continuous subcutaneous insulin infusion pumps. © 2014 Diabetes Technology Society.

  2. Pumps; Pumpen

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, H. [Gesellschaft fuer Praktische Energiekunde e.V., Muenchen (Germany). Forschungsstelle fuer Energiewirtschaft; Hellriegel, E. [Gesellschaft fuer Praktische Energiekunde e.V., Muenchen (Germany). Forschungsstelle fuer Energiewirtschaft; Pfitzner, G. [Gesellschaft fuer Praktische Energiekunde e.V., Muenchen (Germany). Forschungsstelle fuer Energiewirtschaft

    1994-11-01

    The technical features of commercial pump types are described with regard to their technical, energy-related and economic parameters, and characteristic data are presented in the form of data sheets. This is to provide a basis for a comparative assessment of different technologies and technical variants. The chapter `System specifications` describes the various fields of application of pumps and the resulting specific requirements. The design and function of the different pump types are described in `Technical description`. `System and plant description dscribes the design and adaptation of pumps, i.e. the adaptation of the plant data to the system requirements. `Data compilation` provides a survey of the types and systematics of the compiled data as well as a decision aid for selecting the pumps best suited to the various applications. The `Data sheet` section describes the structure and handling of the data sheets as well as the data contained therein. The data sheets are contained in the apapendix of this report. The section `General analysis` compares typical technical, energy-related and economic characteristics of the different pump types. This is to enable a rough comparison of pump types and to facilitate decisions. The chapter `Example` illustrates the use of the data sheets by means of a selected example. (orig./GL) [Deutsch] Die vorliegende Arbeit hat zum Ziel, Technik seriengefertigter und marktgaengiger Pumpen in typisierter Form hinsichtlich ihrer technischen, energetischen und wirtschaftlichen Parameter zu beschreiben und ihre charakteristischen Kennwerte in Datenblaettern abzubilden. Damit wird ein grundlegendes Instrument fuer die vergleichende Beurteilung unterschiedlicher Techniken bzw. Technikvarianten hinsichtlich energetischer und wirtschaftlicher Kriterien geschaffen. Im Abschnitt `Systemanforderungen` erfolgt die Beschreibung der einzelnen Anwendungsbereiche fuer Pumpen mit den speziellen daraus resultierenden Anforderungen. Der Aufbau und

  3. New innovative glucose-controlled pump enabling glucose control in a pregnant patitient with diabetes

    DEFF Research Database (Denmark)

    Pilemann-Lyberg, Sascha; Solis, Anette Bratt; Mathiesen, Elisabeth R

    2014-01-01

    Abstract Continuous glucose monitoring enables innovative insulin pumps to stop infusion of insulin at selected blood glucose thresholds. We present the first and successful Danish clinical case using this device, a Medtronics Veo insulin pump, in a patient with numerous cases of severe...... hypoglycaemia during earlier pregnancies. During this treatment insulin infusion was frequently stopped and severe hypoglycaemia prevented in the remaining part of pregnancy...

  4. Types of Breast Pumps

    Science.gov (United States)

    ... Devices Consumer Products Breast Pumps Types of Breast Pumps Share Tweet Linkedin Pin it More sharing options ... used for feeding a baby. Types of Breast Pumps There are three basic types of breast pumps: ...

  5. Design and performance evaluation of the "iTIVA" algorithm for manual infusion of intravenous anesthetics based on effect-site target

    NARCIS (Netherlands)

    D.E. Ramírez (David Eduardo); J.A. Calvache (Jose Andrés)

    2016-01-01

    textabstractIntroduction: Remifentanil and propofol infusion using TCI pumps has proven to be beneficial for the practice of anesthesia but the availability of these systems is limited. Objective: Designing a pharmacokinetic model-based algorithm for calculating manual infusion regimens to achieve p

  6. Design and performance evaluation of the "iTIVA" algorithm for manual infusion of intravenous anesthetics based on effect-site target

    NARCIS (Netherlands)

    D.E. Ramírez (David Eduardo); J.A. Calvache (Jose Andrés)

    2016-01-01

    textabstractIntroduction: Remifentanil and propofol infusion using TCI pumps has proven to be beneficial for the practice of anesthesia but the availability of these systems is limited. Objective: Designing a pharmacokinetic model-based algorithm for calculating manual infusion regimens to achieve p

  7. The performance of a cryogenic pump for the two-phase flow condition

    OpenAIRE

    YAMADA, HITOSHI; WATANABE, Mitsuo; Hasegawa, Satoshi; Kamijo, Kenjiro; 山田, 仁; 渡辺, 光男; 長谷川, 敏; 上條, 謙二郎

    1985-01-01

    An experimental investigation was carried out in order to obtain the performance characteristics of a cryogenic pump under a two-phase flow condition. The experiment used an oxygen pump with an inducer and liquid nitrogen as the test fluid. The vapor volumetric fraction at the pump inlet was calculated with an assumption of a constant enthalpy process across an orifice which was used to generate the two-phase flow at the pump inlet. The results showed that the pump head rise did hardly decrea...

  8. Volumetric flow rate comparisons for water and product on pasteurization systems.

    Science.gov (United States)

    Schlesser, J E; Stroup, W H; McKinstry, J A

    1994-04-01

    A flow calibration tube system was assembled to determine the volumetric flow rates for water and various dairy products through a holding tube, using three different flow promotion methods. With the homogenizer, the volumetric flow rates of water and reconstituted skim milk were within 1.5% of each other. With the positive displacement pump, the flow rate for reconstituted skim milk increased compared with that for water as the pressure increased or temperature decreased. The largest increase in flow rate was at 310-kPa gauge and 20 degrees C. On a magnetic flow meter system, the volumetric flow rates of water and reconstituted skim milk were within .5% of the flow rate measured from the volume collected in a calibrated tank. The flow rate of whole milk was similar to that of skim milk on the three flow promoters evaluated. Ice milk mix increased the flow rate of the positive displacement pump, but not the homogenizer and magnetic flow meter system.

  9. Small bowel enteroclysis using a hemodialysis blood pump

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Soon Jin; Lim, Hyo Keun; Lee, Won Jae; Kim, Kyeong Ah; Lee, Yeon Ok; Hwang, Jung Hwa; Choi, Sang Hee; Lim, Jae Hoon [Samsung Medical Center, Seoul (Korea, Republic of)

    1998-04-01

    The purpose of this study is to describe the usefulness of small bowel enteroclysis using a hemodialysis blood pump. Over 1 16 month period, 135 double contrast small bowel enteroclysis examinations were performed in 132 patients using a hemodialysis blood pump. Following incubation of the proximal jejunum, barium at a dilution of 50 % and 0.5 %-methylcellulose were infused at a constant rate using a hemodialysis blood pump and multiple spot films of the small intestine were obtained. Success rate, quality of radiographs, positive findings, fluoroscopic time and complications were evaluated. It spite of the long fluoroscopic time and invasiveness, double contrast small bowel enteroclysis is useful for the evaluation of small bowel disease. The infusion of barium and methylcellulose using a hemodialysis blood pump give radiographs of good quality. (author). 18 refs., 2 tabs., 10 figs.

  10. Nonequilibrium volumetric response of shocked polymers

    Energy Technology Data Exchange (ETDEWEB)

    Clements, B E [Los Alamos National Laboratory

    2009-01-01

    Polymers are well known for their non-equilibrium deviatoric behavior. However, investigations involving both high rate shock experiments and equilibrium measured thermodynamic quantities remind us that the volumetric behavior also exhibits a non-equilibrium response. Experiments supporting the notion of a non-equilibrium volumetric behavior will be summarized. Following that discussion, a continuum-level theory is proposed that will account for both the equilibrium and non-equilibrium response. Upon finding agreement with experiment, the theory is used to study the relaxation of a shocked polymer back towards its shocked equilibrium state.

  11. [The intraosseous infusion in adult].

    Science.gov (United States)

    Plancade, D; Rüttimann, M; Wagnon, G; Landy, C; Schaeffer, E; Gagnon, N; Nadaud, J; Favier, J-C

    2013-05-01

    Intraosseous infusion is an old knowledge, abandoned in the 1950s in favor of the peripheral vein, and it was essentially described in pediatrics and military medicine. Since 2005, this way is experiencing a resurgence of interest in emergency medicine particularly in adults after the failure's installation of a peripheral vein in order not to waste the time of care and administration of treatment. New devices that allow intraosseous infusion are currently used in humans. We propose to review the different kind of catheters used, to know the main technical characteristics, indications, contraindications and potential complications. We propose a comparison with the peripheral vein and a comparison between the different catheters.

  12. Process conditions and volumetric composition in composites

    DEFF Research Database (Denmark)

    Madsen, Bo

    2013-01-01

    The obtainable volumetric composition in composites is linked to the gravimetric composition, and it is influenced by the conditions of the manufacturing process. A model for the volumetric composition is presented, where the volume fractions of fibers, matrix and porosity are calculated as a fun...... is increased. Altogether, the model is demonstrated to be a valuable tool for a quantitative analysis of the effect of process conditions. Based on the presented findings and considerations, examples of future work are mentioned for the further improvement of the model.......The obtainable volumetric composition in composites is linked to the gravimetric composition, and it is influenced by the conditions of the manufacturing process. A model for the volumetric composition is presented, where the volume fractions of fibers, matrix and porosity are calculated...... as a function of the fiber weight fraction, and where parameters are included for the composite microstructure, and the fiber assembly compaction behavior. Based on experimental data of composites manufactured with different process conditions, together with model predictions, different types of process related...

  13. Indexing Volumetric Shapes with Matching and Packing.

    Science.gov (United States)

    Koes, David Ryan; Camacho, Carlos J

    2015-04-01

    We describe a novel algorithm for bulk-loading an index with high-dimensional data and apply it to the problem of volumetric shape matching. Our matching and packing algorithm is a general approach for packing data according to a similarity metric. First an approximate k-nearest neighbor graph is constructed using vantage-point initialization, an improvement to previous work that decreases construction time while improving the quality of approximation. Then graph matching is iteratively performed to pack related items closely together. The end result is a dense index with good performance. We define a new query specification for shape matching that uses minimum and maximum shape constraints to explicitly specify the spatial requirements of the desired shape. This specification provides a natural language for performing volumetric shape matching and is readily supported by the geometry-based similarity search (GSS) tree, an indexing structure that maintains explicit representations of volumetric shape. We describe our implementation of a GSS tree for volumetric shape matching and provide a comprehensive evaluation of parameter sensitivity, performance, and scalability. Compared to previous bulk-loading algorithms, we find that matching and packing can construct a GSS-tree index in the same amount of time that is denser, flatter, and better performing, with an observed average performance improvement of 2X.

  14. A nationwide study of continuous subcutaneous insulin infusion (CSII) in Denmark

    DEFF Research Database (Denmark)

    Nørgaard, K

    2003-01-01

    AIMS: To record the number of patients treated with continuous subcutaneous insulin infusion (CSII), the attitude to CSII treatment among diabetes care providers and the characteristics of pump users in Denmark. METHODS: A questionnaire was mailed to all departments of endocrinology, internal...... that no more patients were interested and that it did not significantly improve metabolic control. The mean age of pump users was 48.1 +/- 10.5 years and the mean time wearing a pump 14.1 +/- 6.3 years. Mean HbA1c was 7.9 +/- 1.2% during CSII, with a significant difference among the 15 centres (P ....05) and a tendency to be lower in females (P = 0.07). CONCLUSIONS: CSII is infrequently used in Denmark despite pump users showing reasonably good metabolic control. The most common explanations for these low figures are lack of expertise and funding for CSII. If more patients in Denmark were to be offered pumps...

  15. Do perceptions of insulin pump usability impact attitudes toward insulin pump therapy? A pilot study of individuals with type 1 and insulin-treated type 2 diabetes.

    Science.gov (United States)

    Chamberlain, James J; Gilgen, Emily

    2015-01-01

    We assessed the impact of perceived insulin pump usability on attitudes toward insulin pump therapy in diabetic individuals currently treated with multiple daily insulin injections (MDI). This comparative, single-arm study recruited 28 adults with type 1 (n = 16) and insulin-treated type 2 diabetes (n = 12) to evaluate 2 current insulin pumps: Medtronic Revel 723 (Pump 1), Asante Snap Insulin Pump (Pump 2). Participants were randomized 1:1 to 1 of 2 assessment sequences: Pump 1 followed by Pump 2; and Pump 2 followed by Pump 1. Structured observational protocols were utilized to assess participants' ability and time required to learn/perform common tasks associated with pump setup/use. Participants used a modified version of the System Usability Scale (SUS) and investigator-developed questionnaires to rate pump usability and task difficulty; pre-post questionnaires assessed changes in attitudes toward insulin pump therapy. All participants completed the study. SUS scores showed Pump 2 to be more usable than Pump 1 on all usability attributes. Participants rated Pump 2 more positively than Pump 1, overall mean SUS scores of 5.7 versus 4.1 respectively, F(1, 52) = 32.7, P Pump 2 last, 5.3 versus 4.4 for Pump 1 last, F(1, 52) = 10.8, P Pump 2 was preferred for all tasks: manual bolus (86%), bolus calculation (71%), managing basal rates (93%), interpreting alarms (96%), transferring settings (100%), changing insulin and infusion sets (93%), all P pump usability can directly impact acceptance and use of features that may benefit those who wear them. Simpler pump devices that decrease perceptions of complexity may encourage broader use of this technology. © 2014 Diabetes Technology Society.

  16. A cross-sectional international survey of continuous subcutaneous insulin infusion in 377 children and adolescents with type 1 diabetes mellitus from 10 countries

    NARCIS (Netherlands)

    Danne, T; Battelino, T; Kordonouri, O; Hanas, R; Klinkert, C; Ludvigsson, J; Barrio, R; Aebi, C; Gschwend, S; Mullis, PE; Schumacher, U; Zumsteg, U; Morandi, A; Rabbone, [No Value; Cherubini, [No Value; Toni, S; de Beaufort, C; Hindmarsh, P; Sumner, A; van Waarde, WM; van den Berg, N; Phillip, M

    2005-01-01

    Objective: To document current practices using continuous subcutaneous insulin infusion (CSII) by downloading electronically the 90-d pump data held within the pump memory and relating that to clinical data from children and adolescents in different pediatric diabetes centers from Europe and Israel.

  17. Pump characteristics and applications

    CERN Document Server

    Volk, Michael

    2013-01-01

    Providing a wealth of information on pumps and pump systems, Pump Characteristics and Applications, Third Edition details how pump equipment is selected, sized, operated, maintained, and repaired. The book identifies the key components of pumps and pump accessories, introduces the basics of pump and system hydraulics as well as more advanced hydraulic topics, and details various pump types, as well as special materials on seals, motors, variable frequency drives, and other pump-related subjects. It uses example problems throughout the text, reinforcing the practical application of the formulae

  18. Comparison of peristaltic and Venturi pumps in bimanual microincisional cataract surgery.

    Science.gov (United States)

    Karaguzel, Hande; Karalezli, Aylin; Aslan, Bekir Sitki

    2009-12-01

    Comparison of peristaltic and Venturi pumps in bimanual microincision phacoemulsification on the success of the cataract surgery by using sleeveless phaco tip. Bimanual microincision phacoemulsification was done in 49 eyes using a 1.4-mm temporal clear corneal incision. A peristaltic pump was used in 23 eyes, and a Venturi pump was used in 26 eyes for phacoemulsification. Intraoperative complications, anterior chamber stability, and mean duration of surgery were recorded. Duration of surgery was shorter in the Venturi pump group. Anterior chamber stability could not be established in 17 eyes in the peristaltic pump group; it was established in all eyes in the Venturi pump group. Corneal burns were observed in two eyes in the peristaltic pump group and no eyes in the Venturi pump group. Use of a Venturi pump system and a vented gas-forced infusion system can significantly shorten surgery time and reduce risk of thermal burns.

  19. Continuous infusion versus daily injections of growth hormone (GH) for 4 weeks in GH-deficient patients

    DEFF Research Database (Denmark)

    Laursen, Torben; Jørgensen, Jens Otto Lunde; Jakobsen, Grethe;

    1995-01-01

    effects with constant and pulsatile GH delivery. This study was carried out to compare the metabolic effects of longer term continuous infusion vs. daily injections of GH. Thirteen GH-deficient patients were studied in a cross-over design. The patients were randomized to receive GH as a continuous sc...... infusion by means of a portable pump for 1 month and as daily sc injections (at 1900 h) for another month. An average daily GH dosage (+/- SEM) of 3.15 +/- 0.27 IU was administered during both periods. Steady state 24-h profiles of GH, IGF-I, IGF-binding proteins (IGFBPs), insulin, glucose, lipid.......35 (infusion); P infusion induced higher nighttime than daytime GH levels (P = 0.01), indicating a diurnal variation in the absorption or clearance of GH. Serum IGF-I levels (micrograms per L) were slightly higher (P infusion [312...

  20. MONITORING TETESAN INFUS BERBASIS MIKROKONTROLER ATMEGA16

    Directory of Open Access Journals (Sweden)

    Ardiyanto Iqbal Nugroho

    2015-09-01

    Penelitian ini menghasilkan suatu alat monitoring tetesan infus yang dapat memberikan informasi mengenai laju kecepatan tetesan dan kondisi cairan pada infus. Sistem yang secara realtime dimonitoring oleh perawat ini dapat mengurangi permasalahan yang timbul karena kelalaian petugas. Sehingga perawat tidak secara manual dalam mengatur kecepatan tetesan infus dan meningkatkan pelayanan kepada pasien.

  1. 21 CFR 880.6990 - Infusion stand.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Infusion stand. 880.6990 Section 880.6990 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES....6990 Infusion stand. (a) Identification. The infusion stand is a stationary or movable stand...

  2. Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage.

    Science.gov (United States)

    Enomoto, Yukiko; Yoshimura, Shinichi; Yamada, Kiyofumi; Iwama, Toru

    2010-01-01

    The incidence of convulsion and associated factors were retrospectively analyzed in 23 patients with symptomatic cerebral vasospasm following subarachnoid hemorrhage (SAH) who underwent a total of 31 intra-arterial infusion of fasudil hydrochloride (IAFH) procedures in 49 vessels. Fasudil hydrochloride was administered by superselective infusion via a microcatheter positioned at the proximal portion of the affected artery. Thirteen procedures were performed by manually controlled infusion of 30-75 mg fasudil hydrochloride (1.2-3.75 mg/ml) for approximately 10 minutes. Eighteen procedures were performed by continuous infusion of 60 mg fasudil hydrochloride (1.2 mg/ml) by infusion pump at a constant rate of 3 mg/min. Neurological improvement was observed after 18 of 22 procedures in patients with neurological deterioration due to vasospasm. Convulsion during IAFH developed in 4 patients, all treated by manual infusion (p convulsion during IAFH. IAFH was effective for treating cerebral vasospasm following aneurysmal SAH. IAFH at a constant rate of 3 mg/min delivered by infusion pump improved the symptoms of cerebral vasospasm and prevented convulsions during IAFH.

  3. Extended epidural catheter infusions with analgesics for patients with noncancer pain at their homes.

    Science.gov (United States)

    Aldrete, J A

    1997-01-01

    Patients with severe, noncancer pain unresponsive to epidural steroid injections are frequently referred for implantation of a permanent intraspinal device or for surgery. An alternative approach has been evaluated, which involves extended epidural catheter infusions of analgesics. Observations were made in 551 adult patients with severe low back pain due to a variety of nonmalignant causes, who were treated in an ambulatory setting with a total of 3,108 temporary lumbar epidural catheter infusions of low-dose bupivacaine and fentany via disposable infusion pumps. All but a few treatments resulted in good to excellent pain relief, and most permitted patients to increase their physical activities to near normal levels. The cost of this approach was lower than that associated with insertion of an implantable infusion pump. Temporary lumbar epidural catheter infusions represent an option between lumbar epidural steroid injections and more invasive and expensive modalities. The technique is effective in relieving chronic low back pain for extended periods, reducing its long-term intensity, and in some cases abolishing it.

  4. [Inadvertent epidural infusion of paracetamol].

    Science.gov (United States)

    Charco Roca, L M; Ortiz Sánchez, V E; del Pino Moreno, A L

    2014-10-01

    A 45-year-old woman was accidentally administered an epidural infusion of paracetamol instead of levobupivacaine for postoperative pain therapy during the postoperative period of abdominal hysterectomy under general anesthesia combined with epidural analgesia. The patient had no neurological symptoms at any time, although a slight tendency to arterial hypotension that did not require treatment was observed. No rescue analgesia was necessary until 8h after the start of epidural infusion. The incidence of these types of errors is probably underestimated, although there are several cases reported with various drugs. Copyright © 2013 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España. All rights reserved.

  5. Combined surface and volumetric occlusion shading

    KAUST Repository

    Schott, Matthias O.

    2012-02-01

    In this paper, a method for interactive direct volume rendering is proposed that computes ambient occlusion effects for visualizations that combine both volumetric and geometric primitives, specifically tube shaped geometric objects representing streamlines, magnetic field lines or DTI fiber tracts. The proposed algorithm extends the recently proposed Directional Occlusion Shading model to allow the rendering of those geometric shapes in combination with a context providing 3D volume, considering mutual occlusion between structures represented by a volume or geometry. © 2012 IEEE.

  6. Antibacterial activity of epidural infusions.

    Science.gov (United States)

    Coghlan, M W; Davies, M J; Hoyt, C; Joyce, L; Kilner, R; Waters, M J

    2009-01-01

    The incidence of epidural abscess following epidural catheterisation appears to be increasing, being recently reported as one in 1000 among surgical patients. This study was designed to investigate the antibacterial activity of various local anaesthetics and additives, used in epidural infusions, against a range of micro-organisms associated with epidural abscess. The aim was to determine which, if any, epidural infusion solution has the greatest antibacterial activity. Bupivacaine, ropivacaine and levobupivacaine crystals were dissolved and added to Mueller-Hinton Agar in concentrations of 0.06%, 0.125%, 0.2%, 0.25%, 0.5% and 1%. Fentanyl, adrenaline and clonidine were also mixed with agar in isolation and in combination with the local anaesthetics. Using a reference agar dilution method, the minimum inhibitory concentrations were determined for a range of bacteria. Bupivacaine showed antibacterial activity against Staphylococcus aureus, Enterococcus faecalis and Escherichia coli with minimum inhibitory concentrations between 0.125% and 0.25%. It did not inhibit the growth of Pseudomonas aeruginosa at any of the concentrations tested. Levobupivacaine and ropivacaine showed no activity against Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa, even at the highest concentrations tested, and minimal activity against Escherichia coli (minimum inhibitory concentrations 0.5% and 1% respectively). The presence of fentanyl, adrenaline and clonidine had no additional effect on the antibacterial activity of any of the local anaesthetic agents. The low concentrations of local anaesthetic usually used in epidural infusions have minimal antibacterial activity. While the clinical implications of this in vitro study are not known, consideration should be given to increasing the concentration of bupivacaine in an epidural infusion or to administering a daily bolus of 0.25% bupivacaine to reduce the risk of epidural bacterial growth.

  7. Advances in the treatment of porphyria cutanea tarda. Effectiveness of slow subcutaneous desferrioxamine infusion.

    Science.gov (United States)

    Gibertini, P; Rocchi, E; Cassanelli, M; Pietrangelo, A; Ventura, E

    1984-08-01

    The authors present the results of long-term subcutaneous desferrioxamine (DFX) infusion in 16 porphyria cutanea tarda (PCT) patients who cannot undergo repeated phlebotomies because of severe liver damage, haemolytic anemia, cardiovascular impairment or pulmonary and bone tuberculosis. They employed an automatic, portable syringe pump for subcutaneous infusion (8-10 h) to overcome the short half-life of the drug. Photodynamic cutaneous lesions and hyperpigmentation quickly disappeared (2-3 months). Uroporphyrin excretion sharply decreased and normalized within 3-12 months. Also, serum iron and ferritin, as well as liver function, showed a significant improvement. The authors therefore propose subcutaneous DFX therapy in PCT treatment when phlebotomy is contraindicated.

  8. MR volumetric assessment of endolymphatic hydrops

    Energy Technology Data Exchange (ETDEWEB)

    Guerkov, R.; Berman, A.; Jerin, C.; Krause, E. [University of Munich, Department of Otorhinolaryngology Head and Neck Surgery, Grosshadern Medical Centre, Munich (Germany); University of Munich, German Centre for Vertigo and Balance Disorders, Grosshadern Medical Centre, Marchioninistr. 15, 81377, Munich (Germany); Dietrich, O.; Flatz, W.; Ertl-Wagner, B. [University of Munich, Institute of Clinical Radiology, Grosshadern Medical Centre, Munich (Germany); Keeser, D. [University of Munich, Institute of Clinical Radiology, Grosshadern Medical Centre, Munich (Germany); University of Munich, German Centre for Vertigo and Balance Disorders, Grosshadern Medical Centre, Marchioninistr. 15, 81377, Munich (Germany); University of Munich, Department of Psychiatry and Psychotherapy, Innenstadtkliniken Medical Centre, Munich (Germany)

    2014-10-16

    We aimed to volumetrically quantify endolymph and perilymph spaces of the inner ear in order to establish a methodological basis for further investigations into the pathophysiology and therapeutic monitoring of Meniere's disease. Sixteen patients (eight females, aged 38-71 years) with definite unilateral Meniere's disease were included in this study. Magnetic resonance (MR) cisternography with a T2-SPACE sequence was combined with a Real reconstruction inversion recovery (Real-IR) sequence for delineation of inner ear fluid spaces. Machine learning and automated local thresholding segmentation algorithms were applied for three-dimensional (3D) reconstruction and volumetric quantification of endolymphatic hydrops. Test-retest reliability was assessed by the intra-class coefficient; correlation of cochlear endolymph volume ratio with hearing function was assessed by the Pearson correlation coefficient. Endolymph volume ratios could be reliably measured in all patients, with a mean (range) value of 15 % (2-25) for the cochlea and 28 % (12-40) for the vestibulum. Test-retest reliability was excellent, with an intra-class coefficient of 0.99. Cochlear endolymphatic hydrops was significantly correlated with hearing loss (r = 0.747, p = 0.001). MR imaging after local contrast application and image processing, including machine learning and automated local thresholding, enable the volumetric quantification of endolymphatic hydrops. This allows for a quantitative assessment of the effect of therapeutic interventions on endolymphatic hydrops. (orig.)

  9. LMFBR with booster pump in pumping loop

    Science.gov (United States)

    Rubinstein, H.J.

    1975-10-14

    A loop coolant circulation system is described for a liquid metal fast breeder reactor (LMFBR) utilizing a low head, high specific speed booster pump in the hot leg of the coolant loop with the main pump located in the cold leg of the loop, thereby providing the advantages of operating the main pump in the hot leg with the reliability of cold leg pump operation.

  10. Heat pump technology

    CERN Document Server

    Von Cube, Hans Ludwig; Goodall, E G A

    2013-01-01

    Heat Pump Technology discusses the history, underlying concepts, usage, and advancements in the use of heat pumps. The book covers topics such as the applications and types of heat pumps; thermodynamic principles involved in heat pumps such as internal energy, enthalpy, and exergy; and natural heat sources and energy storage. Also discussed are topics such as the importance of the heat pump in the energy industry; heat pump designs and systems; the development of heat pumps over time; and examples of practical everyday uses of heat pumps. The text is recommended for those who would like to kno

  11. Optimizing insulin pump therapy: a quality improvement project.

    Science.gov (United States)

    Meade, Lisa T; Rushton, Wanda E

    2013-01-01

    The purpose of the study was to assess insulin pump use and provide ongoing education. A quality improvement project using a pump assessment questionnaire was implemented at an endocrinology office in the southeastern United States. The questionnaire was designed to evaluate all aspects of insulin pump therapy, including pump operations, infusion set failure, management of acute complications, and usage of advanced device features. Eighty-nine patients (80% with type 1 diabetes and 20% with type 2 diabetes) completed the questionnaire at the endocrinology practice. A certified diabetes educator reviewed the questions with each patient, identifying deficiencies and training opportunities. The most common areas of deficiency identified after implementation of the assessment form included the following: expired or no basal insulin prescription in the event of pump failure or removal, no mupirocin (Bactroban®, GlaxoSmithKline, Research Triangle Park, North Carolina) prescription for suspected site infections, lack of insulin syringe if pump stopped working, failure to check urine ketones, no antiemetic prescription for sick day intervention, using manual bolus instead of bolus calculator, and lack of in-date glucagon kit. Use of a pump assessment questionnaire allows for focused discussion concerning patient behaviors related to pump operations, troubleshooting, and self-management. Incorporating use of a pump assessment questionnaire into routine practice may result in improved patient education and avoidance of adverse events specific to insulin pump therapy.

  12. Baxter elastomeric pumps: Weighing as an alternative to visual inspection.

    Science.gov (United States)

    Cusano, Ellen L; Ali, Raafi; Sawyer, Michael B; Chambers, Carole R; Tang, Patricia A

    2017-01-01

    Purpose Elastomeric pumps are used to administer 46-hour infusions of 5-fluorouracil (5FU). Baxter suggests patients visually monitor their pumps to ensure that infusions are proceeding correctly. This can be confusing and lead to concerns about under- or over-dosing. Baxter has not considered weighing pumps as a validated method for monitoring. This study aims to validate weighing as a more accurate method for patients and healthcare professionals, and describe real life Baxter Infusor™ variability. Methods Patients who had been started on a 46-hour 5FU infusion returned to the clinic approximately 24 h after starting treatment. The pump was weighed on a StarFrit kitchen scale, and date, time, and weights recorded. Patients were asked if they had a preference for weighing or visually inspecting their pump. Results Pumps ( n = 103) were weighed between 17.25 and 27.5 h after connection. The average weight of a pump was 189 g. Of 103 pumps weighed, 99 weighed less than expected, corresponding to average flow rates of 5.69 mL/h over the elapsed time. The expected flow rate is 5 mL/h with 10% variability. Average flow rates within the 17.25- to 27.5-hour window were 4.561 mL/h, which is 8.78% slower than expected, but within the 10% known variability. Forty-seven percent of patients didn't have a preference for either method, but for those who did have a preference, more than twice as many preferred weighing. Conclusion With proper education, weighing Baxter Infusors at home with kitchen scales can be an accepted and objective alternative to the current recommendation of visual inspection.

  13. Dry vacuum pumps

    Science.gov (United States)

    Sibuet, R.

    2008-05-01

    For decades and for ultimate pressure below 1 mbar, oil-sealed Rotary Vane Pumps have been the most popular solution for a wide range of vacuum applications. In the late 80ies, Semiconductor Industry has initiated the development of the first dry roughing pumps. Today SC applications are only using dry pumps and dry pumping packages. Since that time, pumps manufacturers have developed dry vacuum pumps technologies in order to make them attractive for other applications. The trend to replace lubricated pumps by dry pumps is now spreading over many other market segments. For the Semiconductor Industry, it has been quite easy to understand the benefits of dry pumps, in terms of Cost of Ownership, process contamination and up-time. In this paper, Technology of Dry pumps, its application in R&D/industries, merits over conventional pumps and future growth scope will be discussed.

  14. Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats

    Science.gov (United States)

    Adams, G. R.; McCue, S. A.

    1998-01-01

    Insulin-like growth factor I (IGF-I) peptide levels have been shown to increase in overloaded skeletal muscles (G. R. Adams and F. Haddad. J. Appl. Physiol. 81: 2509-2516, 1996). In that study, the increase in IGF-I was found to precede measurable increases in muscle protein and was correlated with an increase in muscle DNA content. The present study was undertaken to test the hypothesis that direct IGF-I infusion would result in an increase in muscle DNA as well as in various measurements of muscle size. Either 0.9% saline or nonsystemic doses of IGF-I were infused directly into a non-weight-bearing muscle of rats, the tibialis anterior (TA), via a fenestrated catheter attached to a subcutaneous miniosmotic pump. Saline infusion had no effect on the mass, protein content, or DNA content of TA muscles. Local IGF-I infusion had no effect on body or heart weight. The absolute weight of the infused TA muscles was approximately 9% greater (P muscles. IGF-I infusion resulted in significant increases in the total protein and DNA content of TA muscles (P hypertrophied TA was similar to that of the contralateral muscles. These results suggest that IGF-I may be acting to directly stimulate processes such as protein synthesis and satellite cell proliferation, which result in skeletal muscle hypertrophy.

  15. Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats

    Science.gov (United States)

    Adams, G. R.; McCue, S. A.

    1998-01-01

    Insulin-like growth factor I (IGF-I) peptide levels have been shown to increase in overloaded skeletal muscles (G. R. Adams and F. Haddad. J. Appl. Physiol. 81: 2509-2516, 1996). In that study, the increase in IGF-I was found to precede measurable increases in muscle protein and was correlated with an increase in muscle DNA content. The present study was undertaken to test the hypothesis that direct IGF-I infusion would result in an increase in muscle DNA as well as in various measurements of muscle size. Either 0.9% saline or nonsystemic doses of IGF-I were infused directly into a non-weight-bearing muscle of rats, the tibialis anterior (TA), via a fenestrated catheter attached to a subcutaneous miniosmotic pump. Saline infusion had no effect on the mass, protein content, or DNA content of TA muscles. Local IGF-I infusion had no effect on body or heart weight. The absolute weight of the infused TA muscles was approximately 9% greater (P muscles. IGF-I infusion resulted in significant increases in the total protein and DNA content of TA muscles (P hypertrophied TA was similar to that of the contralateral muscles. These results suggest that IGF-I may be acting to directly stimulate processes such as protein synthesis and satellite cell proliferation, which result in skeletal muscle hypertrophy.

  16. Heat pumps in combined heat and power systems

    DEFF Research Database (Denmark)

    Ommen, Torben Schmidt; Markussen, Wiebke Brix; Elmegaard, Brian

    2014-01-01

    of the considered cases. When considering a case where the heat pump is located at a CHP (combined heat and power) plant, a configuration that increases the DH return temperature proposes the lowest operation cost, as low as 12 EUR MWh-1 for a 90 °C e 40 °C DH network. Considering the volumetric heating capacity......Heat pumps have previously been proposed as a way to integrate higher amounts of renewable energy in DH (district heating) networks by integrating, e.g., wind power. The paper identifies and compares five generic configurations of heat pumps in DH systems. The operational performance......, a third configuration is superior in all cases. Finally, the three most promising heat pump configurations are integrated in a modified PQ-diagram of the CHP plant. Each show individual advantages, and for two, also disadvantages in order to achieve flexible operation....

  17. MR-compatible pumps versus manual titration of propofol for pediatric sedation.

    Science.gov (United States)

    Abdallah, Claude; Hannallah, Raafat; Patel, Kantilal

    2010-01-01

    This study aimed to review the use of two methods of propofol infusion: a metred burette system where propofol is diluted in Lactated Ringer using the rule of six [ 1 ] or an infusion pump: Medrad Continuum Magnetic resonance (MR) compatible Infusion System (Medrad Inc. Indianola, PA) and to determine the difference, if any, between the total amount of drug delivered, the impact on vital signs, sedation status and discharge time of the patients. With Institutional Review Board (IRB) approval, 140 children aged 0 to 18 years, American Society of Anesthesiologists (ASA) physical status I or II requiring sedation for elective outpatient brain Magnetic Resonance Imaging (MRI) examination were included in the study. A total of 70 patients in each group were studied. The (Mean ± S.D.) total amount of propofol infused was significantly less in the infusion pump group (12.47 ± 7.67 mg/kg) than the metred burette system (15.84 ± 16.13 mg/kg, p = 0.003). There were also significant mean differences in awakening times (26.63 ± 16.35 vs. 37.06 ± 20.98 min, p = 0.006), and discharge times (53.46 ± 21.12 vs. 67.89 ± 26.84 min, p = 0.008) in the infusion pump group versus the buretrol infusion group. This study demonstrates that both infusion techniques preserve haemodynamic stability and are associated with minimal complications. The use of an infusion pump, which consistently maintains accurate dosing, reduces the amount of propofol judged adequate by the anaesthesiologist to achieve sedation in MRI. This leads to a more consistently faster emergence and early discharge after sedation in children undergoing MRI studies.

  18. Centrifugal pump handbook

    CERN Document Server

    Pumps, Sulzer

    2010-01-01

    This long-awaited new edition is the complete reference for engineers and designers working on pump design and development or using centrifugal pumps in the field. This authoritative guide has been developed with access to the technical expertise of the leading centrifugal pump developer, Sulzer Pumps. In addition to providing the most comprehensive centrifugal pump theory and design reference with detailed material on cavitation, erosion, selection of materials, rotor vibration behavior and forces acting on pumps, the handbook also covers key pumping applications topics and operational

  19. Volumetric polymerization shrinkage of contemporary composite resins

    Directory of Open Access Journals (Sweden)

    Halim Nagem Filho

    2007-10-01

    Full Text Available The polymerization shrinkage of composite resins may affect negatively the clinical outcome of the restoration. Extensive research has been carried out to develop new formulations of composite resins in order to provide good handling characteristics and some dimensional stability during polymerization. The purpose of this study was to analyze, in vitro, the magnitude of the volumetric polymerization shrinkage of 7 contemporary composite resins (Definite, Suprafill, SureFil, Filtek Z250, Fill Magic, Alert, and Solitaire to determine whether there are differences among these materials. The tests were conducted with precision of 0.1 mg. The volumetric shrinkage was measured by hydrostatic weighing before and after polymerization and calculated by known mathematical equations. One-way ANOVA (a or = 0.05 was used to determine statistically significant differences in volumetric shrinkage among the tested composite resins. Suprafill (1.87±0.01 and Definite (1.89±0.01 shrank significantly less than the other composite resins. SureFil (2.01±0.06, Filtek Z250 (1.99±0.03, and Fill Magic (2.02±0.02 presented intermediate levels of polymerization shrinkage. Alert and Solitaire presented the highest degree of polymerization shrinkage. Knowing the polymerization shrinkage rates of the commercially available composite resins, the dentist would be able to choose between using composite resins with lower polymerization shrinkage rates or adopting technical or operational procedures to minimize the adverse effects deriving from resin contraction during light-activation.

  20. Continuous intraperitoneal insulin infusion in type 1 diabetes : a 6-year post-trial follow-up

    NARCIS (Netherlands)

    van Dijk, Peter R.; Logtenberg, Susan J. J.; Groenier, Klaas H.; Gans, Rijk. O.B.; Kleefstra, Nanne; Bilo, Henk J. G.

    2014-01-01

    Background: Continuous intraperitoneal insulin infusion (CIPII) with an implantable pump is a treatment option for patients with type 1 diabetes mellitus (T1DM). Aim of the present study was to describe the long-term course of glycaemic control, complications, health related quality of life (HRQOL)

  1. Continuous intraperitoneal insulin infusion in type 1 diabetes : a 6-year post-trial follow-up

    NARCIS (Netherlands)

    van Dijk, Peter R.; Logtenberg, Susan J. J.; Groenier, Klaas H.; Gans, Rijk. O.B.; Kleefstra, Nanne; Bilo, Henk J. G.

    2014-01-01

    Background: Continuous intraperitoneal insulin infusion (CIPII) with an implantable pump is a treatment option for patients with type 1 diabetes mellitus (T1DM). Aim of the present study was to describe the long-term course of glycaemic control, complications, health related quality of life (HRQOL)

  2. A SUBDIVISION SCHEME FOR VOLUMETRIC MODELS

    Institute of Scientific and Technical Information of China (English)

    GhulamMustafa; LiuXuefeng

    2005-01-01

    In this paper, a subdivision scheme which generalizes a surface scheme in previous papers to volume meshes is designed. The scheme exhibits significant control over shrink-age/size of volumetric models. It also has the ability to conveniently incorporate boundaries and creases into a smooth limit shape of models. The method presented here is much simpler and easier as compared to MacCracken and Joy's. This method makes no restrictions on the local topology of meshes. Particularly, it can be applied without any change to meshes of nonmanifold topology.

  3. Volumetric composition in composites and historical data

    DEFF Research Database (Denmark)

    Lilholt, Hans; Madsen, Bo

    2013-01-01

    guidance to the optimal combination of fibre content, matrix content and porosity content, in order to achieve the best obtainable properties. Several composite materials systems have been shown to be handleable with this model. An extensive series of experimental data for the system of cellulose fibres...... and polymer (resin) was produced in 1942 – 1944, and these data have been (re-)analysed by the volumetric composition model, and the property values for density, stiffness and strength have been evaluated. Good agreement has been obtained and some further observations have been extracted from the analysis....

  4. IMITATION OF STANDARD VOLUMETRIC ACTIVITY METAL SAMPLES

    Directory of Open Access Journals (Sweden)

    A. I. Zhukouski

    2016-01-01

    Full Text Available Due to the specific character of problems in the field of ionizing radiation spectroscopy, the R&D and making process of standard volumetric activity metal samples (standard samples for calibration and verification of spectrometric equipment is not only expensive, but also requires the use of highly qualified experts and a unique specific equipment. Theoretical and experimental studies performed have shown the possibility to use imitators as a set of alternating point sources of gamma radiation and metal plates and their use along with standard volumetric activity metal samples for calibration of scintillation-based detectors used in radiation control in metallurgy. Response functions or instrumental spectra of such spectrometer to radionuclides like 137Cs, 134Cs, 152Eu, 154Eu, 60Co, 54Mn, 232Th, 226Ra, 65Zn, 125Sb+125mTe, 106Ru+106Rh, 94Nb, 110mAg, 233U, 234U, 235U and 238U are required for calibration in a given measurement geometry. Standard samples in the form of a probe made of melt metal of a certain diameter and height are used in such measurements. However, the production of reference materials is costly and even problematic for such radionuclides as 94Nb, 125Sb+125mTe, 234U, 235U  etc. A recognized solution to solve this problem is to use the Monte-Carlo simulation method. Instrumental experimental and theoretical spectra obtained by using standard samples and their imitators show a high compliance between experimental spectra of real samples and the theoretical ones of their Monte-Carlo models, between spectra of real samples and the ones of their imitators and finally, between experimental spectra of real sample imitators and the theoretical ones of their Monte-Carlo models. They also have shown the adequacy and consistency of the approach in using a combination of metal scattering layers and reference point gamma-ray sources instead of standard volumetric activity metal samples. As for using several reference point gamma-ray sources

  5. Magnetic volumetric hologram memory with magnetic garnet.

    Science.gov (United States)

    Nakamura, Yuichi; Takagi, Hiroyuki; Lim, Pang Boey; Inoue, Mitsuteru

    2014-06-30

    Holographic memory is a promising next-generation optical memory that has a higher recording density and a higher transfer rate than other types of memory. In holographic memory, magnetic garnet films can serve as rewritable holographic memory media by use of magneto-optical effect. We have now demonstrated that a magnetic hologram can be recorded volumetrically in a ferromagnetic garnet film and that the signal image can be reconstructed from it for the first time. In addition, multiplicity of the magnetic hologram was also confirmed; the image could be reconstructed from a spot overlapped by other spots.

  6. Design of low cost smart infusion device

    Science.gov (United States)

    Saputra, Yohanes David; Purnamaningsih, Retno Wigajatri

    2015-01-01

    We propose design of a smart infusion device suitable for public hospitals in Indonesia. The device comprised of LED, photodiode and DC motor to measure and control the infusion rate, using the principle of LED beam absorption. The infusion rate was identified by using microcontroller and displayed through computer unit. Experiment results for different flow rate level and concentration of Dextrose showed that the device is able to detect, measure, and control the infusion droplets flow rate by the average error rate of 1.0081%.

  7. Alternative backing up pump for turbomolecular pumps

    Science.gov (United States)

    Myneni, Ganapati Rao

    2003-04-22

    As an alternative to the use of a mechanical backing pump in the application of wide range turbomolecular pumps in ultra-high and extra high vacuum applications, palladium oxide is used to convert hydrogen present in the evacuation stream and related volumes to water with the water then being cryo-pumped to a low pressure of below about 1.e.sup.-3 Torr at 150.degree. K. Cryo-pumping is achieved using a low cost Kleemenco cycle cryocooler, a somewhat more expensive thermoelectric cooler, a Venturi cooler or a similar device to achieve the required minimization of hydrogen partial pressure.

  8. Insulin pump treatment in children and adolescents with type 1 diabetes.

    Science.gov (United States)

    Hofer, S; Meraner, D; Koehle, J

    2012-08-01

    Within children and adolescents with type 1 diabetes insulin pump treatment is of increasing interest. Frequency of insulin pump therapy shows a rapid and steep increase in toddlers and young children. Insulin pumps allow a close to physiologic insulin delivery due to basal rates programmed over 24 hours with circadian rhythms taken into account. Furthermore, another advantage of technical devices as insulin pumps is the application of extremely small amounts of insulin, as needed in very young children, with the possibility of titration of infusion rates down to 0.01E/h. Dawn Phenomenon and hypoglycemic events are main indications for insulin pump treatment in children and adolescents. A significant reduction of severe hypoglycemia, especially nocturnal hypoglycemia was shown, whereas a reduction of HbA1c and an improvement of metabolic control has been reported in short term and in some but not all long term studies. Ketoacidosis rate did not increase in insulin pump therapy. Complications due to continuous subcutaneous insulin infusion, like local infections and dermatological changes are frequent but were not associated with glycemic control and did not lead to discontinuation of insulin pump treatment. Pump discontinuation rate in general is low, varying from 1% in very young children up to 6% in pubertal adolescent girls. Insulin pump treatment was shown to be safe and efficient and the simplicity of handling the devices as well as an improvement of quality of life may explain the rapid increase of pump treatment in young children and adolescents with type 1 diabetes.

  9. Large electromagnetic pumps. [LMFBR

    Energy Technology Data Exchange (ETDEWEB)

    Kilman, G.B.

    1976-01-01

    The development of large electromagnetic pumps for the liquid metal heat transfer systems of fission reactors has progressed for a number of years. Such pumps are now planned for fusion reactors and solar plants as well. The Einstein-Szilard (annular) pump has been selected as the preferred configuration. Some of the reasons that electromagnetic pumps may be preferred over mechanical pumps and why the annular configuration was selected are discussed. A detailed electromagnetic analysis of the annular pump, based on slug flow, is presented. The analysis is then used to explore the implications of large size and power on considerations of electromagnetic skin effect, geometric skin effect and the cylindrical geometry.

  10. Centrifugal pumps: fundamentals and classification; Fundamentos y clasificacion de las bombas centrifugas

    Energy Technology Data Exchange (ETDEWEB)

    Solar Manuel, A. M.

    2009-07-01

    Centrifugal pumps are usually employed to impulse water to elevate it, dose it or give it pressure or speed. They can be used with clean water or loaded with high solid concentration and don't work properly with air or another gas flow. There are another less used pumps, coming from volumetric or ram pumps to magnetic ones for specific uses. Centrifugal ones are rotokinetic pumps, like peripherical or lateral channel pumps. They work in a different way that non rotational kinetic ones and static ones. The work approaches their pre definition, selection, installation, operation and maintenance. It also review their morphology, hidromechanic principles and the basic elements pumps are made of. (Author)

  11. The History of Target-Controlled Infusion

    NARCIS (Netherlands)

    Struys, Michel M. R. F.; De Smet, Tom; Glen, John (Iain) B.; Vereecke, Hugo E. M.; Absalom, Anthony R.; Schnider, Thomas W.

    Target-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted (target) drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technical

  12. Pump element for a tube pump

    DEFF Research Database (Denmark)

    2011-01-01

    The invention relates to a tube pump comprising a tube and a pump element inserted in the tube, where the pump element comprises a rod element and a first and a second non-return valve member positioned a distance apart on the rod element. The valve members are oriented in the same direction rela...... to a part of the tube. The invention further relates to a method for creating a flow of a fluid within an at least partly flexible tube by means of a pump element as mentioned above.......The invention relates to a tube pump comprising a tube and a pump element inserted in the tube, where the pump element comprises a rod element and a first and a second non-return valve member positioned a distance apart on the rod element. The valve members are oriented in the same direction...... portion acts to alternately close and open the valve members thereby generating a fluid flow through the tube. The invention further relates to a pump element comprising at least two non-return valve members connected by a rod element, and for insertion in an at least partly flexible tube in such tube...

  13. Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats

    Science.gov (United States)

    Adams, G. R.; McCue, S. A.

    1998-01-01

    Insulin-like growth factor I (IGF-I) peptide levels have been shown to increase in overloaded skeletal muscles (G. R. Adams and F. Haddad. J. Appl. Physiol. 81: 2509-2516, 1996). In that study, the increase in IGF-I was found to precede measurable increases in muscle protein and was correlated with an increase in muscle DNA content. The present study was undertaken to test the hypothesis that direct IGF-I infusion would result in an increase in muscle DNA as well as in various measurements of muscle size. Either 0.9% saline or nonsystemic doses of IGF-I were infused directly into a non-weight-bearing muscle of rats, the tibialis anterior (TA), via a fenestrated catheter attached to a subcutaneous miniosmotic pump. Saline infusion had no effect on the mass, protein content, or DNA content of TA muscles. Local IGF-I infusion had no effect on body or heart weight. The absolute weight of the infused TA muscles was approximately 9% greater (P hypertrophied TA was similar to that of the contralateral muscles. These results suggest that IGF-I may be acting to directly stimulate processes such as protein synthesis and satellite cell proliferation, which result in skeletal muscle hypertrophy.

  14. Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats

    Science.gov (United States)

    Adams, G. R.; McCue, S. A.

    1998-01-01

    Insulin-like growth factor I (IGF-I) peptide levels have been shown to increase in overloaded skeletal muscles (G. R. Adams and F. Haddad. J. Appl. Physiol. 81: 2509-2516, 1996). In that study, the increase in IGF-I was found to precede measurable increases in muscle protein and was correlated with an increase in muscle DNA content. The present study was undertaken to test the hypothesis that direct IGF-I infusion would result in an increase in muscle DNA as well as in various measurements of muscle size. Either 0.9% saline or nonsystemic doses of IGF-I were infused directly into a non-weight-bearing muscle of rats, the tibialis anterior (TA), via a fenestrated catheter attached to a subcutaneous miniosmotic pump. Saline infusion had no effect on the mass, protein content, or DNA content of TA muscles. Local IGF-I infusion had no effect on body or heart weight. The absolute weight of the infused TA muscles was approximately 9% greater (P protein and DNA content of TA muscles (P DNA-to-protein ratio of the hypertrophied TA was similar to that of the contralateral muscles. These results suggest that IGF-I may be acting to directly stimulate processes such as protein synthesis and satellite cell proliferation, which result in skeletal muscle hypertrophy.

  15. Disentangling volumetric and hydrational properties of proteins.

    Science.gov (United States)

    Voloshin, Vladimir P; Medvedev, Nikolai N; Smolin, Nikolai; Geiger, Alfons; Winter, Roland

    2015-02-05

    We used molecular dynamics simulations of a typical monomeric protein, SNase, in combination with Voronoi-Delaunay tessellation to study and analyze the temperature dependence of the apparent volume, Vapp, of the solute. We show that the void volume, VB, created in the boundary region between solute and solvent, determines the temperature dependence of Vapp to a major extent. The less pronounced but still significant temperature dependence of the molecular volume of the solute, VM, is essentially the result of the expansivity of its internal voids, as the van der Waals contribution to VM is practically independent of temperature. Results for polypeptides of different chemical nature feature a similar temperature behavior, suggesting that the boundary/hydration contribution seems to be a universal part of the temperature dependence of Vapp. The results presented here shine new light on the discussion surrounding the physical basis for understanding and decomposing the volumetric properties of proteins and biomolecules in general.

  16. All Photons Imaging Through Volumetric Scattering

    Science.gov (United States)

    Satat, Guy; Heshmat, Barmak; Raviv, Dan; Raskar, Ramesh

    2016-01-01

    Imaging through thick highly scattering media (sample thickness ≫ mean free path) can realize broad applications in biomedical and industrial imaging as well as remote sensing. Here we propose a computational “All Photons Imaging” (API) framework that utilizes time-resolved measurement for imaging through thick volumetric scattering by using both early arrived (non-scattered) and diffused photons. As opposed to other methods which aim to lock on specific photons (coherent, ballistic, acoustically modulated, etc.), this framework aims to use all of the optical signal. Compared to conventional early photon measurements for imaging through a 15 mm tissue phantom, our method shows a two fold improvement in spatial resolution (4db increase in Peak SNR). This all optical, calibration-free framework enables widefield imaging through thick turbid media, and opens new avenues in non-invasive testing, analysis, and diagnosis. PMID:27683065

  17. Proton pump inhibitors

    Science.gov (United States)

    Proton pump inhibitors (PPIs) are medicines that work by reducing the amount of stomach acid made by ... Proton pump inhibitors are used to: Relieve symptoms of acid reflux, or gastroesophageal reflux disease (GERD). This ...

  18. A Technique for Volumetric CSG Based on Morphology

    DEFF Research Database (Denmark)

    Bærentzen, Jakob Andreas; Christensen, Niels Jørgen

    2001-01-01

    In this paper, a new technique for volumetric CSG is presented. The technique requires the input volumes to correspond to solids which fulfill a voxelization suitability criterion. Assume the CSG operation is union. The volumetric union of two such volumes is defined in terms of the voxelization...

  19. Pump for Saturated Liquids

    Science.gov (United States)

    Elliott, D. G.

    1986-01-01

    Boiling liquids pumped by device based on proven components. Expanding saturated liquid in nozzle and diverting its phases along separate paths in liquid/vapor separator raises pressure of liquid. Liquid cooled in process. Pump makes it unnecessary to pressurize cryogenic liquids in order to pump them. Problems of introducing noncondensable pressurizing gas avoided.

  20. Comparative study between target-controlled-infusion and continuous-infusion anesthesia in dogs treated with methotrimeprazine and treated with propofol and remifentanil Estudo comparativo entre anestesia venosa total alvo-controlada e por infusão contínua em cães pré-tratados com levomepromazina e tratados com propofol e remifentanila

    Directory of Open Access Journals (Sweden)

    Eduardo Hatschbach

    2008-02-01

    Full Text Available PURPOSE: To compare two propofol infusion techniques in bitches subjected to ovaryhisterectomy by estimating the efficiency of the propofol target-dose, evaluating the cardiorespiratory and hemogasimetric attributes, and the bispectral scale index (BIS as well as the recovery period characteristics. METHODS: Twenty anesthetized bitches were divided into two groups of 10 each (G1, G2. Animals of G1 were pre-treated with methotrimeprazine and anesthetized with target-controlled propofol infusion by means of a Harvard infusion pump combined to remifentanil through a syringe pump. RESULTS: Bradycardia and light hypotension, hemogasimetric and respiratory stability besides a good myorelaxation, more evident during continuous infusion and good hypnosis. CONCLUSIONS: Dosis used in both techniques, after methotrimeprazine pre-treatment and combined to the opioid, were efficient for the surgery. The target-controlled anesthesia required a smaller anesthetic consumption (propofol with faster recovery periods.OBJETIVO: Comparar duas técnicas de infusão de propofol em cadelas submetidas à ovariohisterectomia, estudando a eficácia da dose alvo de propofol, avaliando os atributos cardiorrespiratórios, hemogasométricos e escala do índice bispectral, (BIS bem como as características do período de recuperação. MÉTODOS: Foram anestesiadas 20 cadelas, distribuídos em dois grupos (GI e GII. Em GI, os animais foram pré-tratados com levomepromazina e anestesiados com propofol por infusão alvo controlada, através de bomba de infusão Harvard pump, associado com remifentanila, através de bomba de seringa. Em GII, os animais receberam o mesmo tratamento de GI, só que ao invés de receberem o propofol por infusão alvo controlada, receberam o propofol em infusão contínua de velocidade fixa. RESULTADOS: Bradicardia e discreta hipotensão, estabilidade hemogasométrica e respiratória, além de um bom miorrelaxamento, mais evidente na infusão cont

  1. Flow variability and its physical causes in infusion technology: a systematic review of in vitro measurement and modeling studies.

    Science.gov (United States)

    Snijder, Roland A; Konings, Maurits K; Lucas, Peter; Egberts, Toine C; Timmerman, Annemoon D

    2015-08-01

    Infusion therapy is medically and technically challenging and frequently associated with medical errors. When administering pharmaceuticals by means of infusion, dosing errors can occur due to flow rate variability. These dosing errors may lead to adverse effects. We aimed to systematically review the available biomedical literature for in vitro measurement and modeling studies that investigated the physical causes of flow rate variability. Special focus was given to syringe pump setups, which are typically used if very accurate drug delivery is required. We aimed to extract from literature the component with the highest mechanical compliance in syringe pump setups. We included 53 studies, six of which were theoretical models, two articles were earlier reviews of infusion literature, and 45 were in vitro measurement studies. Mechanical compliance, flow resistance, and dead volume of infusion systems were stated as the most important and frequently identified physical causes of flow rate variability. The syringe was indicated as the most important source of mechanical compliance in syringe pump setups (9.0×10-9 to 2.1×10-8 l/Pa). Mechanical compliance caused longer flow rate start-up times (from several minutes up to approximately 70 min) and delayed occlusion alarm times (up to 117 min).

  2. Accuracy of a New Patch Pump Based on a Microelectromechanical System (MEMS) Compared to Other Commercially Available Insulin Pumps

    Science.gov (United States)

    Borot, Sophie; Franc, Sylvia; Cristante, Justine; Penfornis, Alfred; Benhamou, Pierre-Yves; Guerci, Bruno; Hanaire, Hélène; Renard, Eric; Reznik, Yves; Simon, Chantal

    2014-01-01

    The JewelPUMP™ (JP) is a new patch pump based on a microelectromechanical system that operates without any plunger. The study aimed to evaluate the infusion accuracy of the JP in vitro and in vivo. For the in vitro studies, commercially available pumps meeting the ISO standard were compared to the JP: the MiniMed® Paradigm® 712 (MP), Accu-Chek® Combo (AC), OmniPod® (OP), Animas® Vibe™ (AN). Pump accuracy was measured over 24 hours using a continuous microweighing method, at 0.1 and 1 IU/h basal rates. The occlusion alarm threshold was measured after a catheter occlusion. The JP, filled with physiological serum, was then tested in 13 patients with type 1 diabetes simultaneously with their own pump for 2 days. The weight difference was used to calculate the infused insulin volume. The JP showed reduced absolute median error rate in vitro over a 15-minute observation window compared to other pumps (1 IU/h): ±1.02% (JP) vs ±1.60% (AN), ±1.66% (AC), ±2.22% (MP), and ±4.63% (OP), P pumps: 21 (19; 25) minutes vs 90 (85; 95), 58 (42; 74), and 143 (132; 218) minutes (AN, AC, MP), P pumps (–2.2 ± 5.6% vs –0.37 ± 4.0%, P = .25). The JP was found to be easier to wear than conventional pumps. The JP is more precise over a short time period, more sensitive to catheter occlusion, well accepted by patients, and consequently, of potential interest for a closed-loop insulin delivery system. PMID:25079676

  3. CT mapping of saline distribution after infusion of saline into the liver in an ex vivo animal model. How much tissue is actually infused in an image-guided procedure?

    Science.gov (United States)

    Burdío, Fernando; Berjano, Enrique; Millan, Olga; Grande, Luis; Poves, Ignasi; Silva, Claudio; de la Fuente, Maria Dolors; Mojal, Sergi

    2013-03-01

    To track the saline during infusion with a 15 G needle into healthy pig livers at high and low infusion rates for 300 s. In each experiment, the needle was inserted into a single lobe of the liver to a depth of at least 2 cm following its longer axis. Two sets of experiments were defined: 1) low infusion rate of 0.1 mL/min (n = 6) and 2) high infusion rate of 1 mL/min (n = 6). Cine CT scans were carried out and three transverse planes were defined around the infusion point (IP), which corresponds with needle tip. Two assessments were performed: 1) a dynamic plane study focused on the time progress of the saline distribution on a single plane, which provided the Mean Percentage of Grayscale Intensity (MPGI); and 2) a volumetric study focused on the three dimensional distribution of the saline around IP at the end of the experiment, which provided the High Intensity Volume Ratio (HIVR). The saline solution was conspicuous around the IP and shortly after heterogeneously inside the vessels. At the high infusion rate, the saline became conspicuous not only much sooner (evident at 20 s) but farther away (mean value of MPGI over 2%, up to 17 mm from the IP) and at a much higher intensity (mean value of MPGI over 10% up to 4 mm from the IP). The lower the radial distance to the IP, the greater the difference in HIVR between both groups. The high infusion rate leads to a faster, wider and a more marked presence of saline than the low rate. The rapid drainage into the hepatic veins may explain the heterogeneous distribution. Copyright © 2012 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  4. Automated segmentation tool for brain infusions.

    Directory of Open Access Journals (Sweden)

    Kathryn Hammond Rosenbluth

    Full Text Available This study presents a computational tool for auto-segmenting the distribution of brain infusions observed by magnetic resonance imaging. Clinical usage of direct infusion is increasing as physicians recognize the need to attain high drug concentrations in the target structure with minimal off-target exposure. By co-infusing a Gadolinium-based contrast agent and visualizing the distribution using real-time using magnetic resonance imaging, physicians can make informed decisions about when to stop or adjust the infusion. However, manual segmentation of the images is tedious and affected by subjective preferences for window levels, image interpolation and personal biases about where to delineate the edge of the sloped shoulder of the infusion. This study presents a computational technique that uses a Gaussian Mixture Model to efficiently classify pixels as belonging to either the high-intensity infusate or low-intensity background. The algorithm was implemented as a distributable plug-in for the widely used imaging platform OsiriX®. Four independent operators segmented fourteen anonymized datasets to validate the tool's performance. The datasets were intra-operative magnetic resonance images of infusions into the thalamus or putamen of non-human primates. The tool effectively reproduced the manual segmentation volumes, while significantly reducing intra-operator variability by 67±18%. The tool will be used to increase efficiency and reduce variability in upcoming clinical trials in neuro-oncology and gene therapy.

  5. Pancreatic enzyme secretion during intravenous fat infusion.

    Science.gov (United States)

    Burns, G P; Stein, T A

    1987-01-01

    The nutritional support of patients with pancreatic and high gastrointestinal fistulas and severe pancreatitis frequently involves intravenous fat infusion. There are conflicting reports on the effect of intravenous fat on pancreatic exocrine secretion. In 10 dogs with chronic pancreatic fistulas, pancreatic juice was collected during secretin (n = 10) or secretin + cholecystokinin (n = 4) stimulation, with and without intravenous fat infusion (5 g/hr). The hormonal-stimulated secretion of lipase, amylase, trypsin, total protein, bicarbonate, and water was unchanged during fat infusion. This study supports the use of intravenous fat as a nutritional source when it is desirable to avoid stimulation of the pancreas.

  6. Soil volumetric water content measurements using TDR technique

    Directory of Open Access Journals (Sweden)

    S. Vincenzi

    1996-06-01

    Full Text Available A physical model to measure some hydrological and thermal parameters in soils will to be set up. The vertical profiles of: volumetric water content, matric potential and temperature will be monitored in different soils. The volumetric soil water content is measured by means of the Time Domain Reflectometry (TDR technique. The result of a test to determine experimentally the reproducibility of the volumetric water content measurements is reported together with the methodology and the results of the analysis of the TDR wave forms. The analysis is based on the calculation of the travel time of the TDR signal in the wave guide embedded in the soil.

  7. Iterative reconstruction of volumetric particle distribution

    Science.gov (United States)

    Wieneke, Bernhard

    2013-02-01

    For tracking the motion of illuminated particles in space and time several volumetric flow measurement techniques are available like 3D-particle tracking velocimetry (3D-PTV) recording images from typically three to four viewing directions. For higher seeding densities and the same experimental setup, tomographic PIV (Tomo-PIV) reconstructs voxel intensities using an iterative tomographic reconstruction algorithm (e.g. multiplicative algebraic reconstruction technique, MART) followed by cross-correlation of sub-volumes computing instantaneous 3D flow fields on a regular grid. A novel hybrid algorithm is proposed here that similar to MART iteratively reconstructs 3D-particle locations by comparing the recorded images with the projections calculated from the particle distribution in the volume. But like 3D-PTV, particles are represented by 3D-positions instead of voxel-based intensity blobs as in MART. Detailed knowledge of the optical transfer function and the particle image shape is mandatory, which may differ for different positions in the volume and for each camera. Using synthetic data it is shown that this method is capable of reconstructing densely seeded flows up to about 0.05 ppp with similar accuracy as Tomo-PIV. Finally the method is validated with experimental data.

  8. Avoiding crystallization of lorazepam during infusion.

    Science.gov (United States)

    Vellema, J; Hunfeld, N G M; Van den Akker, H E A; ter Horst, J H

    2011-12-18

    Lorazepam is a strong sedative for intensive care patients and a commonly used method of administering it to the patient is by infusion of a freshly prepared lorazepam solution. During lorazepam infusion often unwanted lorazepam crystallization occurs, resulting in line obstruction and reduced lorazepam concentrations. With the aid of solubility measurements a solid-liquid phase diagram for lorazepam in mixtures of a commercially available lorazepam solution and an aqueous glucose solution was determined. This confirmed that the glucose solution acts as an anti-solvent, greatly reducing the lorazepam solubility in the infusion solution. Three approaches are proposed to obtain stable lorazepam solutions upon mixing both solutions and thus to prevent crystallization during infusion: (1) using a high lorazepam concentration, and thus a lower glucose solution volume fraction, in the mixed solution; (2) using an elevated temperature during solution preparation and administration; (3) reducing the lorazepam concentration in the commercial lorazepam solution.

  9. The History of Target-Controlled Infusion.

    Science.gov (United States)

    Struys, Michel M R F; De Smet, Tom; Glen, John Iain B; Vereecke, Hugo E M; Absalom, Anthony R; Schnider, Thomas W

    2016-01-01

    Target-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted ("target") drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technical and regulatory issues addressed in prototype development. We also describe the launch of the current clinically available systems.

  10. Infusion Antihypoxants in Children with Critical Conditions

    Directory of Open Access Journals (Sweden)

    Yu. S. Aleksandrovich

    2014-01-01

    Full Text Available Hypoxia and mitochondrial damage are a key component of the pathogenesis and tanatogenesis of a critical condition, suggesting the need for its prevention and maximally rapid elimination. Objective: to analyze the efficacy and safety of infusion antihypoxants used in critically ill children from the results of researches. Materials and methods. Available investigations dealing with infusion therapy in children and papers on the use of infusion antihypoxants in adults in 2005 to 2013 were sought in the medical databases PubMed and Cochrane Library with their free availability and analyzed. Results. The analysis included 70 trials. The pathophysiology and pathobiochemistry of hypoxia in critically ill children are given; the current principles of its correction by infusion therapy are considered in detail. Particular emphasis is placed on trials evaluating the efficacy and safety of succinic acid solutions in children. Main indications for and contraindications to their use are demonstrated. Conclusion. The use of Krebs cycle substrate-based infusion antihypoxants (malate, succinate is an effective and promising procedure for the intensive therapy and correction of hypoxia in both adults and children with critical conditions. Considering the fact that papers on the use of infusion antihypoxants in children are scanty, there is a need for further investigations. 

  11. Speed-variable Switched Differential Pump System for Direct Operation of Hydraulic Cylinders

    DEFF Research Database (Denmark)

    Schmidt, Lasse; Roemer, Daniel Beck; Pedersen, Henrik Clemmensen;

    2015-01-01

    Efforts to overcome the inherent loss of energy due to throttling in valve driven hydraulic systems are many, and various approaches have been proposed by research communities as well as the industry. Recently, a so-called speed-variable differential pump was proposed for direct drive of hydraulic...... differential cylinders. The main idea was here to utilize an electric rotary drive, with the shaft interconnected to two antiparallel fixed displacement gear pumps, to actuate a differential cylinder. With the design carried out such that the area ratio of the cylinder matches the displacement ratio of the two...... gear pumps, the throttling losses are confined to cross port leakage in the cylinder and leakage of the pumps. However, it turns out that the volumetric pump losses and the pressure dynamics of the cylinder and connecting pipes may cause pressure increase- or decrease in the cylinder chambers, which...

  12. Myrtus communis L. infusions: the effect of infusion time on phytochemical composition, antioxidant, and antimicrobial activities.

    Science.gov (United States)

    Messaoud, Chokri; Laabidi, Abdelmonoem; Boussaid, Mohamed

    2012-09-01

    In traditional medicine, myrtle (Myrtus communis L.) is frequently consumed as an infusion and decoction. In this study, we investigate the phenolic and volatile compositions and antioxidant and antibacterial activities of leaf infusions prepared during 3 different times. The total phenolics contents (146.74 to 179.55 mg GAE/g DM) varied significantly between infusions. Eleven phenolic compounds were identified by reversed-phase high-performance liquid chromatography. Phenolic acids (7.64 to 14.28 μmol/g DM) and flavonol glycosides (7.05 to 12.11 μmol/g DM) were the major phenolic fractions of infusions. Significant quantitative variation in 6 phenolic components was observed between infusions. Sixteen volatile components were identified by gas chromatography (GC) and GC mass spectrometry analyses. The main constituents were 1,8-cineole (42.58% to 51.39%), α-terpineol (9.45% to 9.72%), methyl eugenol (6.69% to 7.11%), and linalool (5.91% to 6.06%). Quantitative variations of the volatile components of the analyzed oils in relation to the infusion time were observed. The antioxidant properties of infusions, assayed through DPPH (2,2- diphenyl-1-picrylhydrazyl) method, β-carotene bleaching test, chelating effect on ferrous ions, and ferric reducing power method, were considerable and varied according to the infusion time. Myrtle infusions exhibited a substantial antimicrobial activity against 6 tested bacteria.

  13. Implementation of smart pump technology in a paediatric intensive care unit.

    Science.gov (United States)

    Manrique-Rodríguez, Silvia; Sánchez-Galindo, Amelia C; de Lorenzo-Pinto, Ana; González-Vives, Leticia; López-Herce, Jesús; Carrillo-Álvarez, Ángel; Sanjurjo-Sáez, María; Fernández-Llamazares, Cecilia M

    2015-09-01

    Patient safety is a matter of major concern that involves every health professional. Nowadays, emerging technologies such as smart pumps can diminish medication errors as well as standardise and improve clinical practice with the subsequent benefits for patients. The aim of this paper was to describe the smart pump implementation process in a paediatric intensive care unit (PICU) and to present the most relevant infusion-related programming errors that were prevented. This was a comparative study between CareFusion Alaris Guardrails(®) and Hospira MedNet(®) systems, as well as a prospective and intervention study with analytical components carried out in the PICU of Gregorio Marañón General and Teaching Hospital. All intravenous infusions programmed with a pump in the eleven beds of the unit were analyzed. A drug library was developed and subsequently loaded into CareFusion and Hospira pumps that were used during a three month period each. The most suitable system for implementation was selected according to their differences in features and users' acceptance. Data stored in the pumps were analyzed to assess user compliance with the technology, health care setting and type of errors intercepted. The implementation process was carried out with CareFusion systems. Compliance with the technology was 92% and user acceptance was high. Vacation substitution and drug administration periods were significantly associated with a greater number of infusion-related programming errors. High risk drugs were involved in 48% of intercepted errors. Based on these results we can conclude that implementation of smart pumps proved effective in intercepting infusion-related programming errors from reaching patients. User awareness of the importance of programming infusions with the drug library is the key to succeed in the implementation process. © The Author(s) 2013.

  14. Microfabricated infuse-withdraw micropump component for an integrated inner-ear drug-delivery platform.

    Science.gov (United States)

    Tandon, Vishal; Kang, Woo Seok; Spencer, Abigail J; Kim, Ernest S; Pararas, Erin E L; McKenna, Michael J; Kujawa, Sharon G; Mescher, Mark J; Fiering, Jason; Sewell, William F; Borenstein, Jeffrey T

    2015-04-01

    One of the major challenges in treatment of auditory disorders is that many therapeutic compounds are toxic when delivered systemically. Local intracochlear delivery methods are becoming critical in emerging treatments and in drug discovery. Direct infusion via cochleostomy, in particular, is attractive from a pharmacokinetics standpoint, as there is potential for the kinetics of delivery to be well-controlled. Direct infusion is compatible with a large number of drug types, including large, complex molecules such as proteins and unstable molecules such as siRNA. In addition, hair-cell regeneration therapy will likely require long-term delivery of a timed series of agents. This presents unknown risks associated with increasing the volume of fluid within the cochlea and mechanical damage caused during delivery. There are three key requirements for an intracochlear drug delivery system: (1) a high degree of miniaturization (2) a method for pumping precise and small volumes of fluid into the cochlea in a highly controlled manner, and (3) a method for removing excess fluid from the limited cochlear fluid space. To that end, our group is developing a head-mounted microfluidics-based system for long-term intracochlear drug delivery. We utilize guinea pig animal models for development and demonstration of the device. Central to the system is an infuse-withdraw micropump component that, unlike previous micropump-based systems, has fully integrated drug and fluid storage compartments. Here we characterize the infuse-withdraw capabilities of our micropump, and show experimental results that demonstrate direct drug infusion via cochleostomy in animal models. We utilized DNQX, a glutamate receptor antagonist that suppresses CAPs, as a test drug. We monitored the frequency-dependent changes in auditory nerve CAPs during drug infusion, and observed CAP suppression consistent with the expected drug transport path based on the geometry and tonotopic organization of the cochlea.

  15. Characterizing volumetric deformation behavior of naturally occuring bituminous sand materials

    CSIR Research Space (South Africa)

    Anochie-Boateng, Joseph

    2009-05-01

    Full Text Available newly proposed hydrostatic compression test procedure. The test procedure applies field loading conditions of off-road construction and mining equipment to closely simulate the volumetric deformation and stiffness behaviour of oil sand materials. Based...

  16. Hyperspectral image classification based on volumetric texture and dimensionality reduction

    Science.gov (United States)

    Su, Hongjun; Sheng, Yehua; Du, Peijun; Chen, Chen; Liu, Kui

    2015-06-01

    A novel approach using volumetric texture and reduced-spectral features is presented for hyperspectral image classification. Using this approach, the volumetric textural features were extracted by volumetric gray-level co-occurrence matrices (VGLCM). The spectral features were extracted by minimum estimated abundance covariance (MEAC) and linear prediction (LP)-based band selection, and a semi-supervised k-means (SKM) clustering method with deleting the worst cluster (SKMd) bandclustering algorithms. Moreover, four feature combination schemes were designed for hyperspectral image classification by using spectral and textural features. It has been proven that the proposed method using VGLCM outperforms the gray-level co-occurrence matrices (GLCM) method, and the experimental results indicate that the combination of spectral information with volumetric textural features leads to an improved classification performance in hyperspectral imagery.

  17. Designing remote web-based mechanical-volumetric flow meter ...

    African Journals Online (AJOL)

    ... remote web-based mechanical-volumetric flow meter reading systems based on ... damage and also provides the ability to control and manage consumption. ... existing infrastructure of the telecommunications is used in data transmission.

  18. Use of intrathecal morphine infusion for spasticity Uso de morfina intratecal para tratamento de espasticidade

    Directory of Open Access Journals (Sweden)

    Luis A. Rogano

    2004-06-01

    Full Text Available OBJECTIVE: To study the efficacy of intrathecal morphine infusion to treat spasticity. Setting: Functional Neurosurgery Division of University of São Paulo, Brazil. METHOD: Twelve patients with clinical refractory spasticity were studied. Two females and 10 males, with median age of 34.4 years (20 to 61 ys.. The initial Ashworth scale was 4.6. They were submitted to pump implantation for intrathecal morphine infusion. RESULTS: The final Ashworth scale was 2.2. The median dose concentration of Intrathecal morphine was 0.95 mg, with a mean frequency of 1.8 times a day. Four patients developed pruritus, two patients nausea, two patients urinary retention, however all improved after morphine concentration was decreased. One patient was submitted to pump rewiew after extrusion catheter. CONCLUSIONS: Intrathecal morphine infusion is very helpful in patients with spasticity refractory to clinical treatment, and we observed only minor complications.OBJETIVO: Estudar a eficiência do uso da infusão de morfina intratecal, no tratamento da espasticidade. MÉTODO: Doze pacientes com espasticidade refratária a tratamento clínico foram estudados. Dez eram do sexo masculino e dois do feminino. A idade média foi 34,4 anos (20 a 61 anos. A média inicial da escala de Ashworth foi 4,6. Todos foram submetidos a implante de bomba de infusão para infusão Intratecal de morfina. RESULTADOS: Ao final do tratamento o valor da escala de Ashworth foi 2,2. A dose média de infusão intratecal de morfina foi 0,95 mg, com freqüência de aplicação de 1,8 vezes/dia. Como complicações, quatro pacientes desenvolveram prurido, dois náuseas, dois retenção urinária e todos melhoraram com diminuição da concentração da morfina intratecal. Um paciente foi submetido à revisão da bomba de morfina por extrusão do cateter. CONCLUSÃO: O uso de morfina intratecal para o tratamento de espasticidade refratária a tratamento clínico é eficaz e com poucas complicações.

  19. Detection of pump degradation

    Energy Technology Data Exchange (ETDEWEB)

    Greene, R.H.; Casada, D.A.; Ayers, C.W. [and others

    1995-08-01

    This Phase II Nuclear Plant Aging Research study examines the methods of detecting pump degradation that are currently employed in domestic and overseas nuclear facilities. This report evaluates the criteria mandated by required pump testing at U.S. nuclear power plants and compares them to those features characteristic of state-of-the-art diagnostic programs and practices currently implemented by other major industries. Since the working condition of the pump driver is crucial to pump operability, a brief review of new applications of motor diagnostics is provided that highlights recent developments in this technology. The routine collection and analysis of spectral data is superior to all other technologies in its ability to accurately detect numerous types and causes of pump degradation. Existing ASME Code testing criteria do not require the evaluation of pump vibration spectra but instead overall vibration amplitude. The mechanical information discernible from vibration amplitude analysis is limited, and several cases of pump failure were not detected in their early stages by vibration monitoring. Since spectral analysis can provide a wealth of pertinent information concerning the mechanical condition of rotating machinery, its incorporation into ASME testing criteria could merit a relaxation in the monthly-to-quarterly testing schedules that seek to verify and assure pump operability. Pump drivers are not included in the current battery of testing. Operational problems thought to be caused by pump degradation were found to be the result of motor degradation. Recent advances in nonintrusive monitoring techniques have made motor diagnostics a viable technology for assessing motor operability. Motor current/power analysis can detect rotor bar degradation and ascertain ranges of hydraulically unstable operation for a particular pump and motor set. The concept of using motor current or power fluctuations as an indicator of pump hydraulic load stability is presented.

  20. Detection of pump degradation

    Energy Technology Data Exchange (ETDEWEB)

    Casada, D. [Oak Ridge National Lab., TN (United States)

    1995-04-01

    There are a variety of stressors that can affect the operation of centrifugal pumps. Although these general stressors are active in essentially all centrifugal pumps, the stressor level and the extent of wear and degradation can vary greatly. Parameters that affect the extent of stressor activity are manifold. In order to assure the long-term operational readiness of a pump, it is important to both understand the nature and magnitude of the specific degradation mechanisms and to monitor the performance of the pump. The most commonly applied method of monitoring the condition of not only pumps, but rotating machinery in general, is vibration analysis. Periodic or continuous special vibration analysis is a cornerstone of most pump monitoring programs. In the nuclear industry, non-spectral vibration monitoring of safety-related pumps is performed in accordance with the ASME code. Pump head and flow rate are also monitored, per code requirements. Although vibration analysis has dominated the condition monitoring field for many years, there are other measures that have been historically used to help understand pump condition; advances in historically applied technologies and developing technologies offer improved monitoring capabilities. The capabilities of several technologies (including vibration analysis, dynamic pressure analysis, and motor power analysis) to detect the presence and magnitude of both stressors and resultant degradation are discussed.

  1. Optically pumped atoms

    CERN Document Server

    Happer, William; Walker, Thad

    2010-01-01

    Covering the most important knowledge on optical pumping of atoms, this ready reference is backed by numerous examples of modelling computation for optical pumped systems. The authors show for the first time that modern scientific computing software makes it practical to analyze the full, multilevel system of optically pumped atoms. To make the discussion less abstract, the authors have illustrated key points with sections of MATLAB codes. To make most effective use of contemporary mathematical software, it is especially useful to analyze optical pumping situations in the Liouville spa

  2. Champagne Heat Pump

    Science.gov (United States)

    Jones, Jack A.

    2004-01-01

    The term champagne heat pump denotes a developmental heat pump that exploits a cycle of absorption and desorption of carbon dioxide in an alcohol or other organic liquid. Whereas most heat pumps in common use in the United States are energized by mechanical compression, the champagne heat pump is energized by heating. The concept of heat pumps based on other absorption cycles energized by heat has been understood for years, but some of these heat pumps are outlawed in many areas because of the potential hazards posed by leakage of working fluids. For example, in the case of the water/ammonia cycle, there are potential hazards of toxicity and flammability. The organic-liquid/carbon dioxide absorption/desorption cycle of the champagne heat pump is similar to the water/ammonia cycle, but carbon dioxide is nontoxic and environmentally benign, and one can choose an alcohol or other organic liquid that is also relatively nontoxic and environmentally benign. Two candidate nonalcohol organic liquids are isobutyl acetate and amyl acetate. Although alcohols and many other organic liquids are flammable, they present little or no flammability hazard in the champagne heat pump because only the nonflammable carbon dioxide component of the refrigerant mixture is circulated to the evaporator and condenser heat exchangers, which are the only components of the heat pump in direct contact with air in habitable spaces.

  3. Serial volumetric registration of pulmonary CT studies

    Science.gov (United States)

    Silva, José Silvestre; Silva, Augusto; Sousa Santos, Beatriz

    2008-03-01

    Detailed morphological analysis of pulmonary structures and tissue, provided by modern CT scanners, is of utmost importance as in the case of oncological applications both for diagnosis, treatment, and follow-up. In this case, a patient may go through several tomographic studies throughout a period of time originating volumetric sets of image data that must be appropriately registered in order to track suspicious radiological findings. The structures or regions of interest may change their position or shape in CT exams acquired at different moments, due to postural, physiologic or pathologic changes, so, the exams should be registered before any follow-up information can be extracted. Postural mismatching throughout time is practically impossible to avoid being particularly evident when imaging is performed at the limiting spatial resolution. In this paper, we propose a method for intra-patient registration of pulmonary CT studies, to assist in the management of the oncological pathology. Our method takes advantage of prior segmentation work. In the first step, the pulmonary segmentation is performed where trachea and main bronchi are identified. Then, the registration method proceeds with a longitudinal alignment based on morphological features of the lungs, such as the position of the carina, the pulmonary areas, the centers of mass and the pulmonary trans-axial principal axis. The final step corresponds to the trans-axial registration of the corresponding pulmonary masked regions. This is accomplished by a pairwise sectional registration process driven by an iterative search of the affine transformation parameters leading to optimal similarity metrics. Results with several cases of intra-patient, intra-modality registration, up to 7 time points, show that this method provides accurate registration which is needed for quantitative tracking of lesions and the development of image fusion strategies that may effectively assist the follow-up process.

  4. Volumetric optoacoustic monitoring of endovenous laser treatments

    Science.gov (United States)

    Fehm, Thomas F.; Deán-Ben, Xosé L.; Schaur, Peter; Sroka, Ronald; Razansky, Daniel

    2016-03-01

    Chronic venous insufficiency (CVI) is one of the most common medical conditions with reported prevalence estimates as high as 30% in the adult population. Although conservative management with compression therapy may improve the symptoms associated with CVI, healing often demands invasive procedures. Besides established surgical methods like vein stripping or bypassing, endovenous laser therapy (ELT) emerged as a promising novel treatment option during the last 15 years offering multiple advantages such as less pain and faster recovery. Much of the treatment success hereby depends on monitoring of the treatment progression using clinical imaging modalities such as Doppler ultrasound. The latter however do not provide sufficient contrast, spatial resolution and three-dimensional imaging capacity which is necessary for accurate online lesion assessment during treatment. As a consequence, incidence of recanalization, lack of vessel occlusion and collateral damage remains highly variable among patients. In this study, we examined the capacity of volumetric optoacoustic tomography (VOT) for real-time monitoring of ELT using an ex-vivo ox foot model. ELT was performed on subcutaneous veins while optoacoustic signals were acquired and reconstructed in real-time and at a spatial resolution in the order of 200μm. VOT images showed spatio-temporal maps of the lesion progression, characteristics of the vessel wall, and position of the ablation fiber's tip during the pull back. It was also possible to correlate the images with the temperature elevation measured in the area adjacent to the ablation spot. We conclude that VOT is a promising tool for providing online feedback during endovenous laser therapy.

  5. Treatment planning for volumetric modulated arc therapy

    Energy Technology Data Exchange (ETDEWEB)

    Bedford, James L. [Joint Department of Physics, Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT (United Kingdom)

    2009-11-15

    Purpose: Volumetric modulated arc therapy (VMAT) is a specific type of intensity-modulated radiation therapy (IMRT) in which the gantry speed, multileaf collimator (MLC) leaf position, and dose rate vary continuously during delivery. A treatment planning system for VMAT is presented. Methods: Arc control points are created uniformly throughout one or more arcs. An iterative least-squares algorithm is used to generate a fluence profile at every control point. The control points are then grouped and all of the control points in a given group are used to approximate the fluence profiles. A direct-aperture optimization is then used to improve the solution, taking into account the allowed range of leaf motion of the MLC. Dose is calculated using a fast convolution algorithm and the motion between control points is approximated by 100 interpolated dose calculation points. The method has been applied to five cases, consisting of lung, rectum, prostate and seminal vesicles, prostate and pelvic lymph nodes, and head and neck. The resulting plans have been compared with segmental (step-and-shoot) IMRT and delivered and verified on an Elekta Synergy to ensure practicality. Results: For the lung, prostate and seminal vesicles, and rectum cases, VMAT provides a plan of similar quality to segmental IMRT but with faster delivery by up to a factor of 4. For the prostate and pelvic nodes and head-and-neck cases, the critical structure doses are reduced with VMAT, both of these cases having a longer delivery time than IMRT. The plans in general verify successfully, although the agreement between planned and measured doses is not very close for the more complex cases, particularly the head-and-neck case. Conclusions: Depending upon the emphasis in the treatment planning, VMAT provides treatment plans which are higher in quality and/or faster to deliver than IMRT. The scheme described has been successfully introduced into clinical use.

  6. Resonance wave pumping: wave mass transport pumping

    Science.gov (United States)

    Carmigniani, Remi; Violeau, Damien; Gharib, Morteza

    2016-11-01

    It has been previously reported that pinching at intrinsic resonance frequencies a valveless pump (or Liebau pump) results in a strong pulsating flow. A free-surface version of the Liebau pump is presented. The experiment consists of a closed tank with a submerged plate separating the water into a free-surface and a recirculation section connected through two openings at each end of the tank. A paddle is placed at an off-centre position at the free-surface and controlled in a heaving motion with different frequencies and amplitudes. Near certain frequencies identified as resonance frequencies through a linear potential theory analysis, the system behaves like a pump. Particle Image Velocimetry (PIV) is performed in the near free surface region and compared with simulations using Volume of Fluid (VOF) method. The mean eulerian mass flux field (ρ) is extracted. It is observed that the flow is located in the vicinity of the surface layer suggesting Stokes Drift (or Wave Mass Transport) is the source of the pumping. A model is developped to extend the linear potential theory to the second order to take into account these observations. The authors would like to acknowledge the Gordon and Betty Moore Foundation for their generous support.

  7. A remote drip infusion monitoring system employing Bluetooth.

    Science.gov (United States)

    Amano, Hikaru; Ogawa, Hidekuni; Maki, Hiromichi; Tsukamoto, Sosuke; Yonezawa, Yoshiharu; Caldwell, W Morton

    2012-01-01

    We have developed a remote drip infusion monitoring system for use in hospitals. The system consists of several infusion monitoring devices and a central monitor. The infusion monitoring device employing a Bluetooth module can detect the drip infusion rate and an empty infusion solution bag, and then these data are sent to the central monitor placed at the nurses' station via the Bluetooth. The central monitor receives the data from several infusion monitoring devices and then displays graphically them. Therefore, the developed system can monitor intensively the drip infusion situation of the several patients at the nurses' station.

  8. Visualization and volumetric structures from MR images of the brain

    Energy Technology Data Exchange (ETDEWEB)

    Parvin, B.; Johnston, W.; Robertson, D.

    1994-03-01

    Pinta is a system for segmentation and visualization of anatomical structures obtained from serial sections reconstructed from magnetic resonance imaging. The system approaches the segmentation problem by assigning each volumetric region to an anatomical structure. This is accomplished by satisfying constraints at the pixel level, slice level, and volumetric level. Each slice is represented by an attributed graph, where nodes correspond to regions and links correspond to the relations between regions. These regions are obtained by grouping pixels based on similarity and proximity. The slice level attributed graphs are then coerced to form a volumetric attributed graph, where volumetric consistency can be verified. The main novelty of our approach is in the use of the volumetric graph to ensure consistency from symbolic representations obtained from individual slices. In this fashion, the system allows errors to be made at the slice level, yet removes them when the volumetric consistency cannot be verified. Once the segmentation is complete, the 3D surfaces of the brain can be constructed and visualized.

  9. Soft bilateral filtering volumetric shadows using cube shadow maps

    Science.gov (United States)

    Ali, Hatam H.; Sunar, Mohd Shahrizal; Kolivand, Hoshang

    2017-01-01

    Volumetric shadows often increase the realism of rendered scenes in computer graphics. Typical volumetric shadows techniques do not provide a smooth transition effect in real-time with conservation on crispness of boundaries. This research presents a new technique for generating high quality volumetric shadows by sampling and interpolation. Contrary to conventional ray marching method, which requires extensive time, this proposed technique adopts downsampling in calculating ray marching. Furthermore, light scattering is computed in High Dynamic Range buffer to generate tone mapping. The bilateral interpolation is used along a view rays to smooth transition of volumetric shadows with respect to preserving-edges. In addition, this technique applied a cube shadow map to create multiple shadows. The contribution of this technique isreducing the number of sample points in evaluating light scattering and then introducing bilateral interpolation to improve volumetric shadows. This contribution is done by removing the inherent deficiencies significantly in shadow maps. This technique allows obtaining soft marvelous volumetric shadows, having a good performance and high quality, which show its potential for interactive applications. PMID:28632740

  10. Demanding pump power; Krevende pumpekraft

    Energy Technology Data Exchange (ETDEWEB)

    Lie, Oeyvind

    2011-07-01

    The potential for pump power in Norway is huge, but it is difficult to exploit it. Norway has some pumping plants, but these are built for seasonal pumping (pumping up to the magazine in the summer, and production in the winter). Pump power plants for short periods do not exist in Norway. (AG)

  11. Theoretical study of heat pump system using CO2/dimethylether as refrigerant

    Directory of Open Access Journals (Sweden)

    Fan Xiao-Wei

    2013-01-01

    Full Text Available Nowadays, HCFC22 is widely used in heat pump systems in China, which should be phased out in the future. Thus, eco-friendly mixture CO2/dimethylether is proposed to replace HCFC22. Compared with pure CO2 and pure dimethylether, the mixture can reduce the heat rejection pressure, and suppress the flammability and explosivity of pure dimethylether. According to the Chinese National Standards on heat pump water heater and space heating system, performances of the subcritical heat pump system are discussed and compared with those of the HCFC22 system. It can be concluded that CO2 /dimethylether mixture works efficiently as a refrigerant for heat pumps with a large heat-sink temperature rise. When mass fraction of dimethylether is increased, the heat rejection pressure is reduced. Under the nominal working condition, there is an optimal mixture mass fraction of 28/72 of CO2/dimethylether for water heater application under conventional condensation pressure, 3/97 for space heating application. For water heater application, both the heating coefficient of performance and volumetric heating capacity increase by 17.90% and 2.74%, respectively, compared with those of HCFC22 systems. For space heating application, the heating coefficient of performance increases by 8.44% while volumetric heating capacity decreases by 34.76%, compared with those of HCFC22 systems. As the superheat degree increases, both the heating coefficient of performance and volumetric heating capacity tend to decrease.

  12. Pump element for a tube pump

    DEFF Research Database (Denmark)

    2011-01-01

    relative to the rod element so as to allow for a fluid flow in the tube through the first valve member, along the rod element, and through the second valve member. The tube comprises an at least partly flexible tube portion between the valve members such that a repeated deformation of the flexible tube...... portion acts to alternately close and open the valve members thereby generating a fluid flow through the tube. The invention further relates to a pump element comprising at least two non-return valve members connected by a rod element, and for insertion in an at least partly flexible tube in such tube...... pump as mentioned above, thereby acting to generate a fluid flow through the tube upon repeated deformation of the tube between the two valve members. The pump element may comprise a connecting part for coupling to another tube and may comprise a sealing part establishing a fluid tight connection...

  13. Endothelial Cell Toxicity of Vancomycin Infusion Combined with Other Antibiotics

    OpenAIRE

    Drouet, Maryline; Chai, Feng; Barthélémy, Christine; Lebuffe, Gilles; Debaene, Bertrand; Décaudin, Bertrand; Odou, Pascal

    2015-01-01

    French guidelines recommend central intravenous (i.v.) infusion for high concentrations of vancomycin, but peripheral intravenous (p.i.v.) infusion is often preferred in intensive care units. Vancomycin infusion has been implicated in cases of phlebitis, with endothelial toxicity depending on the drug concentration and the duration of the infusion. Vancomycin is frequently infused in combination with other i.v. antibiotics through the same administrative Y site, but the local toxicity of such...

  14. Performance and acceptability of a combined device for insulin infusion and glucose sensing in the home setting

    DEFF Research Database (Denmark)

    Nørgaard, K.; Shin, J.; Welsh, J. B.

    2015-01-01

    The use of sensor-augmented insulin pump (SAP) therapy is increasing. Currently, glucose sensors and insulin infusion cannulas are inserted separately. A new device, MiniMed Duo, combines sensing and infusion capabilities on the same platform and is intended to simplify device insertion and site...... connected to insulin pumps over 15 days (3 days/device) and test capillary blood glucose (SMBG) 7 times/day. The primary endpoint was the percentage of sensor-SMBG paired values within 20% of one another. Subject experiences were assessed via questionnaires. Overall, 74.8% of sensor-SMBG paired values were...... management. We evaluated the device's performance with respect to insulin delivery and glucose sensing, and its acceptability with patients. Forty-five patients (mean +/- SD age, 45.5 +/- 10.9 years, 48% female) with type 1 diabetes and previous use of SAP participated. Each subject was to wear 5 devices...

  15. Achieving effective glycaemic control using an insulin micro-pump.

    Science.gov (United States)

    Kelly, Peter

    2017-02-02

    For those with type 1 diabetes mellitus (T1DM), a deranged blood glucose level can cause hypo/hyperglycaemic episodes and in the long term contribute to microvascular disease. Such outcomes can effect concordance with insulin management regimens and affect the patient's quality of life. A variety of insulin delivery methods are available, including continuous subcutaneous insulin infusion (CSII) via either a tethered or patch pump. Pumps have the potential to improve delivery, monitoring and adjustment of insulin regimens, thus freeing patient's time and affording more control of their disease. This article reports how a new patch pump, has helped a cohort of patients to improve blood glucose variability levels and thus quality of life.

  16. A Shocking New Pump

    Science.gov (United States)

    2000-01-01

    Hydro Dynamics, Inc. received a technical helping hand from NASA that made their Hydrosonic Pump (HPump) a reality. Marshall engineers resolved a bearing problem in the rotor of the pump and recommended new bearings, housings and mounting hardware as a solution. The resulting HPump is able to heat liquids with greater energy efficiency using shock waves to generate heat.

  17. Water Treatment Technology - Pumps.

    Science.gov (United States)

    Ross-Harrington, Melinda; Kincaid, G. David

    One of twelve water treatment technology units, this student manual on pumps provides instructional materials for three competencies. (The twelve units are designed for a continuing education training course for public water supply operators.) The competencies focus on the following areas: types of pumps in plant and distribution systems, pump…

  18. A Novel Technique for Split-Thickness Skin Donor Site Pain Control: Subcutaneous Catheters for Continuous Local Anesthetic Infusion

    Science.gov (United States)

    2012-01-01

    has been described after laparotomy, tho- racotomy, inguinal hernia repair, and rib fractures.2–4 We describe our experience at the U.S. Army Insti... complications (one catheter insertion site infection and one early catheter discontinuation due to poor skin fixation). This report is limited by its...Sanchez B, Waxman K, Tatevossian R, Gamberdella M, Read B. Local anesthetic infusion pumps improve postoperative pain after inguinal hernia repair: a

  19. Review of magnetohydrodynamic pump applications

    National Research Council Canada - National Science Library

    Al-Habahbeh, O.M; Al-Saqqa, M; Safi, M; Abo Khater, T

    2016-01-01

    Magneto-hydrodynamic (MHD) principle is an important interdisciplinary field. One of the most important applications of this effect is pumping of materials that are hard to pump using conventional pumps...

  20. Runaway electron beam control for longitudinally pumped metal vapor lasers

    Science.gov (United States)

    Kolbychev, G. V.; Kolbycheva, P. D.

    1995-08-01

    Physics and techniques for producing of the pulsed runaway electron beams are considered. The main obstacle for increasing electron energies in the beams is revealed to be a self- breakdown of the e-gun's gas-filled diode. Two methods to suppress the self-breakdown and enhance the volumetric discharge producing the e-beam are offered and examined. Each of them provides 1.5 fold increase of the ceiling potential on the gun. The methods also give the ways to control several guns simultaneously. Resulting in the possibility of realizing the powerful longitudinal pumping of metal-vapor lasers on self-terminated transitions of atoms or ions.

  1. FLOW DIRECTION OF PIEZOELEC-TRIC PUMP WITH NOZZLE/DIFFUSER-ELEMENTS

    Institute of Scientific and Technical Information of China (English)

    Zhang Jianhui; Xia Qixiao; Hong Zhen; Onuki Akiyoshi

    2004-01-01

    The piezoelectric pump with nozzle/diffuser-elements, which oscillating form differing from regular volumetric reciprocating or rotating pumps because there are nozzle/diffuser-elements substituted for regular valves, is a new type pump whose actuator is a piezoelectric ceramal part with verse piezoelectric effect.In recent year, piezoelectric pump is paid increasing attention to because it is an ideal candidate in application in such area as medical health, mechanical tools and micro-mechanism.The fundamental research on it, however, is still not made through.Focuses on the phenomenon of different directions of flow among Germany pump, Chinese pump and Swiss pump, which are all fitted with nozzle/diffuser-elements, and analyzes the cone angle of nozzle/diffuser-elements based on the flow equation of valve-less piezoelectric pump with nozzle/diffuser-elements.As a result, the concepts of diffuser loss coefficient and loss coefficient are introduced to explain these phenomena, from which a discussion is given on the optimization of the cone angle of nozzle/diffuser-element aiming at the maximum of pump flow.

  2. How to minimize toxic exposure to pyridine during continuous infusion of ceftazidime in patients with cystic fibrosis?

    Science.gov (United States)

    Bourget, P; Amin, A; Dupont, C; Abely, M; Desmazes-Dufeu, N; Dubus, J C; Jouani, B-L; Merlette, C; Nové-Josserand, R; Pages, J; Panzo, R; Vidal, F; Voge, F; Hubert, D

    2014-05-01

    Ceftazidime is particularly efficient against Pseudomonas aeruginosa in cystic fibrosis patients. Thus, the spontaneous production of pyridine, which is a toxic product, raises some concern. Our aim was to examine the kinetics of degradation of ceftazidime in portable infusion pumps either at 4°C, 22°C, or 33°C and to propose some recommendations in order to reduce the pyridine exposure. Two administration models were studied in vitro. In model 1, we administered 12 g of ceftazidime infused over 23 h (once-daily infusion) compared to 6 g infused over 11.5 h in model 2 (twice-daily regimen). Samples were collected at 0 h and then every 4 and 2 h after the shaping of portable infusion pumps in models 1 and 2, respectively. Both ceftazidime and pyridine were analyzed using an ultraviolet high-performance liquid chromatograph. Production of pyridine is highly depending on the temperature. The in situ production of pyridine per day of treatment decreases at a ratio close to 1/6 and 1/3 between 33°C and 4°C in models 1 and 2, respectively. Regardless of the conditions, the production of pyridine is significantly lower in model 2, whereas the total delivery amount of ceftazidime is significantly higher at 4°C and 33°C compared to that in model 1. According to a the precautionary principle, these findings lead to three major recommendations: (i) exposing a solution of ceftazidime to over 22°C should be strictly avoided, (ii) a divided dose of 6 g over 11.5 h instead of a once-daily administration is preferred, and (iii) infusion should be administered immediately after reconstitution.

  3. Onset Time and Durability of Huntingtin Suppression in Rhesus Putamen After Direct Infusion of Antihuntingtin siRNA.

    Science.gov (United States)

    Grondin, Richard; Ge, Pei; Chen, Qingmin; Sutherland, Jessica E; Zhang, Zhiming; Gash, Don M; Stiles, David K; Stewart, Gregory R; Sah, Dinah W Y; Kaemmerer, William F

    2015-06-30

    One possible treatment for Huntington's disease involves direct infusion of a small, interfering RNA (siRNA) designed to reduce huntingtin expression into brain tissue from a chronically implanted programmable pump. Here, we studied the suppression of huntingtin mRNA achievable with short infusion times, and investigated how long suppression may persist after infusion ceases. Rhesus monkeys received 3 days of infusion of Magnevist into the putamen to confirm catheter patency and fluid distribution. After a 1-week washout period, monkeys received radiolabeled siRNA targeting huntingtin. After 1 or 3 days of siRNA delivery, monkeys were either terminated, or their pumps were shut off and they were terminated 10 or 24 days later. Results indicate that the onset of huntingtin mRNA suppression in the rhesus putamen occurs rapidly, achieving a plateau throughout the putamen within 4 days. Conversely, loss of huntingtin suppression progresses slowly, persisting an estimated 27-39 days in the putamen and surrounding white matter. These findings indicate the rapid onset and durability of siRNA-mediated target gene suppression observed in other organs also occurs in the brain, and support the use of episodic delivery of siRNA into the brain for treatment of Huntington's disease and possibly other neurodegenerative diseases.

  4. Onset Time and Durability of Huntingtin Suppression in Rhesus Putamen After Direct Infusion of Antihuntingtin siRNA

    Directory of Open Access Journals (Sweden)

    Richard Grondin

    2015-01-01

    Full Text Available One possible treatment for Huntington's disease involves direct infusion of a small, interfering RNA (siRNA designed to reduce huntingtin expression into brain tissue from a chronically implanted programmable pump. Here, we studied the suppression of huntingtin mRNA achievable with short infusion times, and investigated how long suppression may persist after infusion ceases. Rhesus monkeys received 3 days of infusion of Magnevist into the putamen to confirm catheter patency and fluid distribution. After a 1-week washout period, monkeys received radiolabeled siRNA targeting huntingtin. After 1 or 3 days of siRNA delivery, monkeys were either terminated, or their pumps were shut off and they were terminated 10 or 24 days later. Results indicate that the onset of huntingtin mRNA suppression in the rhesus putamen occurs rapidly, achieving a plateau throughout the putamen within 4 days. Conversely, loss of huntingtin suppression progresses slowly, persisting an estimated 27–39 days in the putamen and surrounding white matter. These findings indicate the rapid onset and durability of siRNA-mediated target gene suppression observed in other organs also occurs in the brain, and support the use of episodic delivery of siRNA into the brain for treatment of Huntington's disease and possibly other neurodegenerative diseases.

  5. Forearm metabolism during infusion of adrenaline

    DEFF Research Database (Denmark)

    Simonsen, L; Stefl, B; Bülow, J

    2000-01-01

    Human skeletal muscle metabolism is often investigated by measurements of substrate fluxes across the forearm. To evaluate whether the two forearms give the same metabolic information, nine healthy subjects were studied in the fasted state and during infusion of adrenaline. Both arms were...... catheterized in a cubital vein in the retrograde direction. A femoral artery was catheterized for blood sampling, and a femoral vein for infusion of adrenaline. Forearm blood flow was measured by venous occlusion strain-gauge plethysmography. Forearm subcutaneous adipose tissue blood flow was measured...... by the local 133Xe washout method. Metabolic fluxes were calculated as the product of forearm blood flow and a-v differences of metabolite concentrations. After baseline measurements, adrenaline was infused at a rate of 0.3 nmol kg-1 min-1. No difference in the metabolic information obtained in the fasting...

  6. Pumping machinery theory and practice

    CERN Document Server

    Badr, Hassan M

    2014-01-01

    Pumping Machinery Theory and Practice comprehensively covers the theoretical foundation and applications of pumping machinery. Key features: Covers characteristics of centrifugal pumps, axial flow pumps and displacement pumpsConsiders pumping machinery performance and operational-type problemsCovers advanced topics in pumping machinery including multiphase flow principles, and two and three-phase flow pumping systemsCovers different methods of flow rate control and relevance to machine efficiency and energy consumptionCovers different methods of flow rate control and relevance to machine effi

  7. Influence of Valve's Characteristic on Total Performance of Three Cylinders Internal Combustion Water Pump

    Institute of Scientific and Technical Information of China (English)

    ZHANG Hongxin; ZHANG Tiezhu; WANG Weichao

    2009-01-01

    lntenal combustion pump (ICP) is a new type power device turning the thermal energy from fuel combustion into fluid pressure energy. Three cylinders prototype has just been developed. The study on the influence of valve's characteristic on ICP's total performance will found the base for its optimum design. Based on the theoretical and testing fruits of single cylinder prototype, the performance of the valves and complete appliance of the latest is simulated. When the natural frequency of valves is approximately to the round number times of the working frequency, volumetric efficiency is seriously low. The nominal rotational speed of the prototype is nearly to the speed where the volumetric efficiency is lowest, which is harmful to the normal work of ICP, so further structure optimization of valves should be carried out. The change of volumetric efficiency has great influence on the fuel consumption rate,output flow, effective thermal efficiency, effective power, and so on, but little on output pressure.

  8. Possible Radio Interference Between Video Capsule Endoscopy and Second-Generation OmniPod Patch Pump.

    Science.gov (United States)

    Pitocco, Dario; Rizzi, Alessandro; Tortora, Annalisa; Manto, Andrea; Zaccardi, Francesco; Ghirlanda, Giovanni; Costamagna, Guido; Riccioni, Maria Elena

    2016-07-01

    Video capsule endoscopy (VCE) is a noninvasive diagnostic tool used to observe the small intestinal mucosa. We report a case of a 57-year-old woman with T2DM, treated with continuous subcutaneous insulin infusion using second-generation OmniPod patch pump, undergoing VCE (Given M2A; VCE Ltd, Yoqneam, Israel) for melena and anemia. During VCE, an abnormal interruption of communication between video capsule and its receiver occurred. Two hours after capsule ingestion, the patient activated the insulin pump infusion through the Personal Diabetes Manager (PDM) because she drank a sugary beverage for the first time after ingestion. Due to this, we decided to repeat VCE after the removal of the insulin pump and PDM: at this time, the capsule recorded for more than 10 h without any interruption. The video capsule and second-generation OmniPod patch pump use the same radio frequency and this may cause interference between these two devices. In patients using second-generation OmniPod patch pump undergoing VCE, we suggest to switch to intravenous insulin infusion or multiple daily injection or to use a different model of VCE, as MiRoCam (Intromedic, Seoul, Korea).

  9. Comparison of rechargeable versus battery-operated insulin pumps: temperature fluctuations

    Directory of Open Access Journals (Sweden)

    Vereshchetin P

    2016-10-01

    Full Text Available Paul Vereshchetin, Thomas W McCann Jr, Navdeep Ojha, Ramakrishna Venugopalan, Brian L Levy Johnson & Johnson Diabetes Care Companies, Chesterbrook, PA, USA Abstract: The role of continuous subcutaneous insulin infusion (insulin pumps has become increasingly important in diabetes management, and many different types of these systems are currently available. This exploratory study focused on the reported heating issues that lithium-ion battery-powered pumps may have during charging compared with battery-operated pumps. It was found that pump temperature increased by 6.4°C during a long charging cycle of a lithium-ion battery-operated pump under ambient temperatures. In an environmental-chamber kept at 35°C, the pump temperature increased by 4.4°C, which indicates that the pump temperature was above that of the recommended safety limit for insulin storage of 37°C. When designing new pumps, and when using currently available rechargeable pumps in warmer climates, the implications of these temperature increases should be taken into consideration. Future studies should also further examine insulin quality after charging. Keywords: insulin pumps, diabetes mellitus, safety, heating

  10. Evaluation of sub-fascial lidocaine infusion in post-operative pain management following laparotomy

    Directory of Open Access Journals (Sweden)

    F. Eshghi

    2008-01-01

    Full Text Available  AbstractBackground and Purpose: One of the important problems of major abdominal surgery is post-operative pain control. There are different modalities to control the pain after surgery, such as oral, local or intravenous analgesic drugs, regional nerve block, epidural catheters and pain killer pumps with their own benefits and complications. The aim of this study was to evaluate the effect of continuous peritoneal infusion of lidocaine by a pain killer pump for post-operative pain management following laparotomy.Materials and Methods: This double blind randomized clinical trial was performed on 76 patients (38 cases and 38 controls who underwent laparotomy with midline incision, in Imam Hospital, Sari, Iran, in 2008. Two groups were matched in age and sex. After surgery a catheter infusion pump was prepared for all patients. In case group, 2% lidocaine (20mg/kg/day and for control, normal saline infused for 24 hours. Pain score (Visual Analog Scale, blood pressure, heart rate, respiratory rate, temperature and analgesic requirement was evaluated in 4, 10, 16 and 24 hours after surgery. Results analyzed by means of SPSS (15 software and chi-square, t test and repeated measurement. The p value less than 0.05 was considered to be significant statistically.Results: 76 patients, 39 (51.3% females and 37 (48.7% males, with mean age of 47.03±15.2 years were studied. There was no significant difference in age, sex and weight between two groups. The mean of admission days was 5.03±0.6 in case and 5.29±1.3 in control, with no significant difference between them. Mean of opiod consumption was 16.05±13.05 mg and 25.39±11.4 mg in case and control respectively (P= 0.002. Mean of VAS score, blood pressure, heart rate, respiratory rate and temperature in case group was less than control group and the difference was significant statistically. Pain severity changes during 4, 10, 16 and 24 hours following surgery were significantly different in two

  11. Effect of methoxamine continuous pump infusion on cognitive function in elderly patients with total hip replacement%甲氧明持续泵注对老年全髋关节置换术患者认知功能的影响

    Institute of Scientific and Technical Information of China (English)

    郭正轩; 胡张钊

    2016-01-01

    目的:观察甲氧明持续泵注在老年患者全髋关节置换手术中血流动力学变化和术后认知功能的影响。方法选择择期行全髋关节置换手术患者60例,采用腰-硬联合麻醉,随机分为两组,A组麻醉成功后静脉给予甲氧明2~3mg,随后持续泵注甲氧明10~25ml/h(甲氧明20mg稀释到50ml生理盐水),B组不给甲氧明,根据需要给予麻黄素或去甲肾上腺素。记录麻醉前(T0)、麻醉后即刻(T1)、麻醉后15分钟(T2)、扩髓结束(T3)、手术结束时(T4)的血压、心率,评估术前1天,术后第1天、3天、7天的MESS评分。结果与A组比较,B组的麻醉后、术中T1~T4血压均低于A组( P<0.05)。手术后第1~3天的MESS评分B组低于A组,第7天两组MESS评分相似。结论甲氧明持续泵注在老年患者全髋关节置换手术中可以更好地维持血流动力学平稳,能够降低术后短期的认知功能障碍的发生率。%Objectives To observe the changes of hemodynamics and postoperative cognitive function in elderly patients with to -tal hip replacement.Methods Elective total hip replacement surgery in 60 cases,Combined spinal epidural anesthesia ,Randomly divided into two groups ,A group,Intravenous injection methoxamine of 2~3mg after successful anesthesia ,The B group did not give , To give ephedrine or norepinephrine .Recorded blood pressure , heart rate before anesthesia ( T0 ) , immediately after anesthesia (T1),after anesthesia 15min(T2),End of extension (T3),at the end of the operation (T4).Assessment of the day before surgery, the first, third and seventh day of the MESS score .Results Compared with the A group ,the T1 ~T4 blood pressure in the B group was lower than that in the A group (P<0.05) after anesthesia.The MESS score of B group was lower than that of A group at day 1~3 after surgery.Two days of the seventh groups MESS scores were similar .Conclusions Continuous pump

  12. Improved volumetric imaging in tomosynthesis using combined multiaxial sweeps.

    Science.gov (United States)

    Gersh, Jacob A; Wiant, David B; Best, Ryan C M; Bennett, Marcus C; Munley, Michael T; King, June D; McKee, Mahta M; Baydush, Alan H

    2010-09-03

    This study explores the volumetric reconstruction fidelity attainable using tomosynthesis with a kV imaging system which has a unique ability to rotate isocentrically and with multiple degrees of mechanical freedom. More specifically, we seek to investigate volumetric reconstructions by combining multiple limited-angle rotational image acquisition sweeps. By comparing these reconstructed images with those of a CBCT reconstruction, we can gauge the volumetric fidelity of the reconstructions. In surgical situations, the described tomosynthesis-based system could provide high-quality volumetric imaging without requiring patient motion, even with rotational limitations present. Projections were acquired using the Digital Integrated Brachytherapy Unit, or IBU-D. A phantom was used which contained several spherical objects of varying contrast. Using image projections acquired during isocentric sweeps around the phantom, reconstructions were performed by filtered backprojection. For each image acquisition sweep configuration, a contrasting sphere is analyzed using two metrics and compared to a gold standard CBCT reconstruction. Since the intersection of a reconstructed sphere and an imaging plane is ideally a circle with an eccentricity of zero, the first metric presented compares the effective eccentricity of intersections of reconstructed volumes and imaging planes. As another metric of volumetric reconstruction fidelity, the volume of one of the contrasting spheres was determined using manual contouring. By comparing these manually delineated volumes with a CBCT reconstruction, we can gauge the volumetric fidelity of reconstructions. The configuration which yielded the highest overall volumetric reconstruction fidelity, as determined by effective eccentricities and volumetric contouring, consisted of two orthogonally-offset 60° L-arm sweeps and a single C-arm sweep which shared a pivot point with one the L-arm sweeps. When compared to a similar configuration that

  13. Aspects of volumetric efficiency measurement for reciprocating engines

    Directory of Open Access Journals (Sweden)

    Pešić Radivoje B.

    2013-01-01

    Full Text Available The volumetric efficiency significantly influences engine output. Both design and dimensions of an intake and exhaust system have large impact on volumetric efficiency. Experimental equipment for measuring of airflow through the engine, which is placed in the intake system, may affect the results of measurements and distort the real picture of the impact of individual structural factors. This paper deals with the problems of experimental determination of intake airflow using orifice plates and the influence of orifice plate diameter on the results of the measurements. The problems of airflow measurements through a multi-process Otto/Diesel engine were analyzed. An original method for determining volumetric efficiency was developed based on in-cylinder pressure measurement during motored operation, and appropriate calibration of the experimental procedure was performed. Good correlation between the results of application of the original method for determination of volumetric efficiency and the results of theoretical model used in research of influence of the intake pipe length on volumetric efficiency was determined. [Acknowledgments. The paper is the result of the research within the project TR 35041 financed by the Ministry of Science and Technological Development of the Republic of Serbia

  14. Is the air handling capability of the quadrox D pump dependent within an ECMO circuit? An in vitro study.

    Science.gov (United States)

    Gill, Martin C; Dando, Hayden; John, Dittmer

    2010-09-01

    The occurrence of gaseous microemboli (GME) within the extracorporeal membrane oxygenation circuit is largely overlooked, as are methods to ameliorate this occurrence. We aimed to determine if the air handling capability of the Quadrox D oxygenator was dependent upon whether it was used in conjunction with a centrifugal or roller pump; and if application of a Pall air eliminating filter (AEF) would prevent circuit air introduction from intravenous infusions. Using a blood primed circuit 1 mL of air was infused pre pump. GME were quantified post pump and post oxygenator using the EDAC Quantifier. Trials were conducted at 1 and 2 L/min flow. To prevent GME recirculation a Capiox SX18 was used in circuit with negative pressure applied to its oxygenator; an EDAC cuvette distal to this device quantified GME recirculation. Following air infusion, 3-5 minute data recordings were carried out for each trial. Separate trials were carried out for centrifugal and roller pumps, and for each flow rate. The process was then repeated following the application of the AEF to the air infusion line. More GME were detected post Quadrox D when the centrifugal pump was used in comparison to the roller pump at 1 L/min (p < .05), and 2 L/min (p = .05). A greater volume of air was detected post Quadrox D when used in conjunction with the centrifugal device at 1 L/min (p < or = .05), and 2 L/min (p < or = .05). Application of the AEF resulted in zero GME detected at any circuit location. The results of this study confirm that a greater total count and volume of GME are detected distal to the Quadrox D when used in conjunction with a Rotaflow centrifugal pump. Application of a Pall AEF to infusion and drug lines can prevent air introduction from this source.

  15. Haemodynamic responses to exercise, ATP infusion and thigh compression in humans: insight into the role of muscle mechanisms on cardiovascular function

    DEFF Research Database (Denmark)

    Gonzalez-Alonso, J.; Mortensen, S.P.; Jeppesen, Tina Dysgaard

    2008-01-01

    increased blood flow (DeltaLBF 0.5-0.7 l min(-1)) without altering (.)Q, MAP or (.)VO2. These findings suggest that the skeletal muscle pump is not obligatory for sustaining venous return, central venous pressure,stroke volume and (.)Q or maintaining muscle blood flow during one-legged exercise in humans......The muscle pump and muscle vasodilatory mechanism are thought to play important roles in increasing and maintaining muscle perfusion and cardiac output ((.)Q) during exercise, but their actual contributions remain uncertain. To evaluate the role of the skeletal muscle pump and vasodilatation...... on cardiovascular function during exercise, we determined leg and systemic haemodynamic responses in healthy men during (1) incremental one-legged knee-extensor exercise, (2) step-wise femoral artery ATP infusion at rest, (3) passive exercise (n=10), (4)femoral vein or artery ATP infusion (n=6), and (5) cyclic...

  16. Effect of steel and teflon infusion catheters on subcutaneous adipose tissue blood flow and infusion counter pressure in humans

    DEFF Research Database (Denmark)

    Højbjerre, Lise; Skov-Jensen, Camilla; Kaastrup, Peter;

    2009-01-01

    microcirculation and infusion counter pressure. METHODS: One steel catheter and one Teflon (Dupont, Wilmington, DE) catheter were inserted in subcutaneous, abdominal adipose tissue (SCAAT) in 10 healthy, lean men. The catheters were infused with isotonic saline at a rate of 10 microL/h for 48 h. Another steel...... catheter and a Teflon catheter were inserted contralateral to the previous catheters after 48 h. The infusion counter pressure was measured during a basal infusion rate followed by a bolus infusion. The measurements during a basal rate infusion were repeated after the bolus infusion. Adipose tissue blood...... flow (ATBF) was measured in SCAAT continuously. RESULTS: A significant increase in ATBF was observed with wear time for Teflon but not for steel catheters. Mean infusion pressure during the bolus phase increased significantly from 0 to 48 h for Teflon but not for steel catheters. ATBF and infusion...

  17. Lower dose basal insulin infusion has positive effect on glycaemic control for children with type I diabetes on continuous subcutaneous insulin infusion therapy.

    Science.gov (United States)

    Schulten, Ron J; Piet, Jessica; Bruijning, Patricia Cjl; de Waal, Wouter J

    2017-02-01

    The aim of our study was to explore a possible relationship between proportion of basal insulin dose (%BD/T) and glycaemic control in children with type I diabetes on continuous subcutaneous insulin infusion (CSII) therapy. All patients under the age of 18 with type I diabetes mellitus, treated in a general hospital in Utrecht, The Netherlands, who were on CSII therapy between 2000 and 2011 were selected for inclusion. All data as recorded during outpatient visits were retrospectively collected from patients' charts. Analyses were performed using R Statistical Software. Data of 847 outpatient visits of 78 patients [31 males (39.7%) and 47 females (60.3%)] were analyzed. Mean age at diagnosis was 7.1 ± 3.7 yr, mean age at start of pump therapy 10.1 ± 3.8 yr. Mean HbA1c before pump start was 8.3 ± 1.0%, median BMI standard deviation score for age and gender was 0.64 (-1.89-3.79). Median follow-up time per patient was 29 months with an average of 10 visits (range: 3-25). Multivariate analysis revealed that a change of 10% in %BD/T resulted in a decrease or increase of HbA1c of 0.22% [95% confidence interval (CI): 0.15-0.29). No significant effect was observed from SDS BMI, sex, or duration of diabetes. Low dose basal insulin infusion as a percentage of total insulin dose has a positive effect on metabolic outcome as expressed in HbA1c-levels. A change of 10% in %BD/T results in a decrease or increase of HbA1c of 0.22%. This supports the tendency to aim at the lowest basal insulin requirements in pump setting strategy. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  18. A high volume, high throughput volumetric sorption analyzer

    Science.gov (United States)

    Soo, Y. C.; Beckner, M.; Romanos, J.; Wexler, C.; Pfeifer, P.; Buckley, P.; Clement, J.

    2011-03-01

    In this talk we will present an overview of our new Hydrogen Test Fixture (HTF) constructed by the Midwest Research Institute for The Alliance for Collaborative Research in Alternative Fuel Technology to test activated carbon monoliths for hydrogen gas storage. The HTF is an automated, computer-controlled volumetric instrument for rapid screening and manipulation of monoliths under an inert atmosphere (to exclude degradation of carbon from exposure to oxygen). The HTF allows us to measure large quantity (up to 500 g) of sample in a 0.5 l test tank, making our results less sensitive to sample inhomogeneity. The HTF can measure isotherms at pressures ranging from 1 to 300 bar at room temperature. For comparison, other volumetric instruments such as Hiden Isochema's HTP-1 Volumetric Analyser can only measure carbon samples up to 150 mg at pressures up to 200 bar. Work supported by the US DOD Contract # N00164-08-C-GS37.

  19. Volumetric (3D) compressive sensing spectral domain optical coherence tomography.

    Science.gov (United States)

    Xu, Daguang; Huang, Yong; Kang, Jin U

    2014-11-01

    In this work, we proposed a novel three-dimensional compressive sensing (CS) approach for spectral domain optical coherence tomography (SD OCT) volumetric image acquisition and reconstruction. Instead of taking a spectral volume whose size is the same as that of the volumetric image, our method uses a sub set of the original spectral volume that is under-sampled in all three dimensions, which reduces the amount of spectral measurements to less than 20% of that required by the Shan-non/Nyquist theory. The 3D image is recovered from the under-sampled spectral data dimension-by-dimension using the proposed three-step CS reconstruction strategy. Experimental results show that our method can significantly reduce the sampling rate required for a volumetric SD OCT image while preserving the image quality.

  20. Infusing interprofessional education into the nursing curriculum.

    Science.gov (United States)

    Cranford, Joan Sistrunk; Bates, Teresa

    2015-01-01

    Education for interprofessional collaboration should begin early in the nursing program with a gradual infusion of interprofessional competencies into the curriculum. The faculty developed an interprofessional education program for students in nursing, physical therapy, nutrition, and respiratory care, which focused on sharing knowledge about each discipline, developing respect and value for each other's disciplines, and emphasizing techniques to improve communication and teamwork.

  1. Propofol Infusion Syndrome Heralded by ECG Changes

    NARCIS (Netherlands)

    Mijzen, Elsbeth J.; Jacobs, Bram; Aslan, Adnan; Rodgers, Michael G. G.

    2012-01-01

    Propofol infusion syndrome (PRIS) is well known, often associated with, lethal complication of sedation with propofol. PRIS seems to be associated with young age, traumatic brain injury (TBI), higher cumulative doses of propofol, and the concomitant use of catecholamines. Known manifestations of

  2. Liquid infused surfaces in turbulent channel flow

    Science.gov (United States)

    Fu, Matthew; Stone, Howard; Smits, Alexander; Jacobi, Ian; Samaha, Mohamed; Wexler, Jason; Shang, Jessica; Rosenberg, Brian; Hellström, Leo; Fan, Yuyang; Wang, Karen; Lee, Kevin; Hultmark, Marcus

    2014-11-01

    A turbulent channel flow facility is used to measure the drag reduction capabilities and dynamic behavior of liquid-infused micro-patterned surfaces. Liquid infused surfaces have been proposed as a robust alternative to traditional air-cushion-based superhydrophobic surfaces. The mobile liquid lubricant creates a surface slip with the outer turbulent shear flow as well as an energetic sink to dampen turbulent fluctuations. Micro-manufactured surfaces can be mounted flush in the channel and exposed to turbulent flows. Two configurations are possible, both capable of producing laminar and turbulent flows. The first configuration allows detailed investigation of the infused liquid layer and the other allows well resolved pressure gradient measurements. Both of the configurations have high aspect ratios 15-45:1. Drag reduction for a variety of liquid-infused surface architectures is quantified by measuring pressure drop in the channel. Flow in the oil film is simultaneously visualized using fluorescent dye. Supported under ONR Grants N00014-12-1-0875 and N00014-12-1-0962 (program manager Ki-Han Kim).

  3. Implementation of a Prolonged Infusion Guideline for Time-Dependent Antimicrobial Agents at a Tertiary Academic Medical Center.

    Science.gov (United States)

    Hohlfelder, Benjamin; Kubiak, David W; Degrado, Jeremy R; Reardon, David P; Szumita, Paul M

    Administration of time-dependent beta-lactam antibiotic as a prolonged infusion may maximize the pharmacodynamic target of time above the minimum inhibitory concentration. We describe the implementation of a prolonged infusion at a tertiary academic medical center, and a 1-year compliance analysis with the guideline. After performing a thorough literature search, a guideline was developed by members of the Department of Infectious Diseases and Department of Pharmacy. Approval and endorsement of the guideline was obtained by the Antimicrobial Subcommittee and Pharmacy and Therapeutics Committee. Physical champions were instrumental in the implementation of the guideline institution-wide. We then performed a 1-year retrospective analysis of guideline compliance from January 1, 2011 to December 31, 2011. Noncompliant administrations were obtained from smart infusion pumps. The total number of doses administered was taken from pharmacy information resources. In total, nearly 85,000 time-dependent doses were administered. Compliance with the prolonged infusion guideline was 89%. Rates of compliance did not significantly differ between medications (P = 0.555). Obtaining support from key stakeholders in collateral services and institutional leadership was vital for the success of this guideline. Compliance with the guideline 1 year after implementation was high. Implementation of a prolonged infusion guideline is feasible with institutional support and motivation.

  4. Acute duodenal Crohn's disease successfully managed with low-speed elemental diet infusion via nasogastric tube: A case report

    Institute of Scientific and Technical Information of China (English)

    Takayuki Yamamoto; Maki Nakahigashi; Satoru Umegae; Tatsushi Kitagawa; Koichi Matsumoto

    2006-01-01

    Duodenal Crohn's disease is rare, and patients without obstruction are treated medically. We herein report one case whose duodenal Crohn's disease was successfully managed with low-speed elemental diet infusion through a nasogastric tube. A 28-year-old female developed acute duodenal Crohn's disease. Upper GI radiologic and endoscopic examinations showed a stricture in the duodenal bulb. Using the duodenal biopsy specimens,mucosal cytokine levels were measured; interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor-α levels were remarkably elevated. For initial 2 wk, powdered mesalazine was orally given but it was not effective. For the next 2 wk, she was treated with low-speed elemental diet therapy using a commercially available ElentalTM,which was infused continuously through a nasogastric tube using an infusion pump. The tip of the nasogastric tube was placed at an immediate oral side of the pylorus.The infusion speed was 10 mL/h (usual speed, 100 mL/h).After the 2-wk treatment, her symptoms were very much improved, and endoscopically, the duodenal stricture and inflammation improved. The duodenal mucosal cytokine levels remarkably decreased compared with those before the treatment. Although our experience was limited, lowspeed elemental diet infusion through a nasogastric tube may be a useful treatment for acute duodenal Crohn's disease.

  5. Multiple sparse volumetric priors for distributed EEG source reconstruction.

    Science.gov (United States)

    Strobbe, Gregor; van Mierlo, Pieter; De Vos, Maarten; Mijović, Bogdan; Hallez, Hans; Van Huffel, Sabine; López, José David; Vandenberghe, Stefaan

    2014-10-15

    We revisit the multiple sparse priors (MSP) algorithm implemented in the statistical parametric mapping software (SPM) for distributed EEG source reconstruction (Friston et al., 2008). In the present implementation, multiple cortical patches are introduced as source priors based on a dipole source space restricted to a cortical surface mesh. In this note, we present a technique to construct volumetric cortical regions to introduce as source priors by restricting the dipole source space to a segmented gray matter layer and using a region growing approach. This extension allows to reconstruct brain structures besides the cortical surface and facilitates the use of more realistic volumetric head models including more layers, such as cerebrospinal fluid (CSF), compared to the standard 3-layered scalp-skull-brain head models. We illustrated the technique with ERP data and anatomical MR images in 12 subjects. Based on the segmented gray matter for each of the subjects, cortical regions were created and introduced as source priors for MSP-inversion assuming two types of head models. The standard 3-layered scalp-skull-brain head models and extended 4-layered head models including CSF. We compared these models with the current implementation by assessing the free energy corresponding with each of the reconstructions using Bayesian model selection for group studies. Strong evidence was found in favor of the volumetric MSP approach compared to the MSP approach based on cortical patches for both types of head models. Overall, the strongest evidence was found in favor of the volumetric MSP reconstructions based on the extended head models including CSF. These results were verified by comparing the reconstructed activity. The use of volumetric cortical regions as source priors is a useful complement to the present implementation as it allows to introduce more complex head models and volumetric source priors in future studies.

  6. Nuclear-pumped lasers

    CERN Document Server

    Prelas, Mark

    2016-01-01

    This book focuses on Nuclear-Pumped Laser (NPL) technology and provides the reader with a fundamental understanding of NPLs, a review of research in the field, and exploration of large scale NPL system design and applications. Early chapters look at the fundamental properties of lasers, nuclear-pumping and nuclear reactions that may be used as drivers for nuclear-pumped lasers. The book goes on to explore the efficient transport of energy from the ionizing radiation to the laser medium and then the operational characteristics of existing nuclear-pumped lasers. Models based on Mathematica, explanations and a tutorial all assist the reader’s understanding of this technology. Later chapters consider the integration of the various systems involved in NPLs and the ways in which they can be used, including beyond the military agenda. As readers will discover, there are significant humanitarian applications for high energy/power lasers, such as deflecting asteroids, space propulsion, power transmission and mining....

  7. Absorption heat pump system

    Science.gov (United States)

    Grossman, G.

    1982-06-16

    The efficiency of an absorption heat pump system is improved by conducting liquid from a second stage evaporator thereof to an auxiliary heat exchanger positioned downstream of a primary heat exchanger in the desorber of the system.

  8. High Voltage Charge Pump

    KAUST Repository

    Emira, Ahmed A.

    2014-10-09

    Various embodiments of a high voltage charge pump are described. One embodiment is a charge pump circuit that comprises a plurality of switching stages each including a clock input, a clock input inverse, a clock output, and a clock output inverse. The circuit further comprises a plurality of pumping capacitors, wherein one or more pumping capacitors are coupled to a corresponding switching stage. The circuit also comprises a maximum selection circuit coupled to a last switching stage among the plurality of switching stages, the maximum selection circuit configured to filter noise on the output clock and the output clock inverse of the last switching stage, the maximum selection circuit further configured to generate a DC output voltage based on the output clock and the output clock inverse of the last switching stage.

  9. Regenerative Hydride Heat Pump

    Science.gov (United States)

    Jones, Jack A.

    1992-01-01

    Hydride heat pump features regenerative heating and single circulation loop. Counterflow heat exchangers accommodate different temperatures of FeTi and LaNi4.7Al0.3 subloops. Heating scheme increases efficiency.

  10. Underground pumped hydroelectric storage

    Science.gov (United States)

    Allen, R. D.; Doherty, T. J.; Kannberg, L. D.

    1984-07-01

    Underground pumped hydroelectric energy storage was conceived as a modification of surface pumped storage to eliminate dependence upon fortuitous topography, provide higher hydraulic heads, and reduce environmental concerns. A UPHS plant offers substantial savings in investment cost over coal-fired cycling plants and savings in system production costs over gas turbines. Potential location near load centers lowers transmission costs and line losses. Environmental impact is less than that for a coal-fired cycling plant. The inherent benefits include those of all pumped storage (i.e., rapid load response, emergency capacity, improvement in efficiency as pumps improve, and capacity for voltage regulation). A UPHS plant would be powered by either a coal-fired or nuclear baseload plant. The economic capacity of a UPHS plant would be in the range of 1000 to 3000 MW. This storage level is compatible with the load-velocity requirements of a greater metropolitan area with population of 1 million or more.

  11. Chiral brownian heat pump.

    Science.gov (United States)

    van den Broek, M; Van den Broeck, C

    2008-04-04

    We present the exact analysis of a chiral Brownian motor and heat pump. Optimization of the construction predicts, for a nanoscale device, frequencies of the order of kHz and cooling rates of the order of femtojoule per second.

  12. Chiral Brownian heat pump

    OpenAIRE

    Van Den Broek, Martijn; Van Den Broeck, Christian

    2007-01-01

    We present the exact analysis of a chiral Brownian motor and heat pump. Optimization of the construction predicts, for a nanoscale device, frequencies of the order of kHz and cooling rates of the order of femtojoule per second.

  13. Regenerative Hydride Heat Pump

    Science.gov (United States)

    Jones, Jack A.

    1992-01-01

    Hydride heat pump features regenerative heating and single circulation loop. Counterflow heat exchangers accommodate different temperatures of FeTi and LaNi4.7Al0.3 subloops. Heating scheme increases efficiency.

  14. Volumetric measurements of a spatially growing dust acoustic wave

    Science.gov (United States)

    Williams, Jeremiah D.

    2012-11-01

    In this study, tomographic particle image velocimetry (tomo-PIV) techniques are used to make volumetric measurements of the dust acoustic wave (DAW) in a weakly coupled dusty plasma system in an argon, dc glow discharge plasma. These tomo-PIV measurements provide the first instantaneous volumetric measurement of a naturally occurring propagating DAW. These measurements reveal over the measured volume that the measured wave mode propagates in all three spatial dimensional and exhibits the same spatial growth rate and wavelength in each spatial direction.

  15. Volumetric measurements of a spatially growing dust acoustic wave

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Jeremiah D. [Physics Department, Wittenberg University, Springfield, Ohio 45504 (United States)

    2012-11-15

    In this study, tomographic particle image velocimetry (tomo-PIV) techniques are used to make volumetric measurements of the dust acoustic wave (DAW) in a weakly coupled dusty plasma system in an argon, dc glow discharge plasma. These tomo-PIV measurements provide the first instantaneous volumetric measurement of a naturally occurring propagating DAW. These measurements reveal over the measured volume that the measured wave mode propagates in all three spatial dimensional and exhibits the same spatial growth rate and wavelength in each spatial direction.

  16. Volumetric Pricing of Agricultural Water Supplies: A Case Study

    Science.gov (United States)

    Griffin, Ronald C.; Perry, Gregory M.

    1985-07-01

    Models of water consumption by rice producers are conceptualized and then estimated using cross-sectional time series data obtained from 16 Texas canal operators for the years 1977-1982. Two alternative econometric models demonstrate that both volumetric and flat rate water charges are strongly and inversely related to agricultural water consumption. Nonprice conservation incentives accompanying flat rates are hypothesized to explain the negative correlation of flat rate charges and water consumption. Application of these results suggests that water supply organizations in the sample population converting to volumetric pricing will generally reduce water consumption.

  17. Intravenous infusions in chronic pain management.

    Science.gov (United States)

    Kosharskyy, Boleslav; Almonte, Wilson; Shaparin, Naum; Pappagallo, Marco; Smith, Howard

    2013-01-01

    In the United States, millions of Americans are affected by chronic pain, which adds heavily to national rates of morbidity, mortality, and disability, with an ever-increasing prevalence. According to a 2011 report titled Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research by the Institute of Medicine of the National Academies, pain not only exacts its toll on people's lives but also on the economy with an estimated annual economic cost of at least $560 - 635 billion in health care costs and the cost of lost productivity attributed to chronic pain. Intravenous infusions of certain pharmacologic agents have been known to provide substantial pain relief in patients with various chronic painful conditions. Some of these infusions are better, and although not necessarily the first therapeutic choice, have been widely used and extensively studied. The others show promise, however are in need of further investigations. This article will focus on non-opiate intravenous infusions that have been utilized for chronic painful disorders such as fibromyalgia, neuropathic pain, phantom limb pain, post-herpetic neuralgia, complex regional pain syndromes (CRPS), diabetic neuropathy, and central pain related to stroke or spinal cord injuries. The management of patients with chronic pain conditions is challenging and continues to evolve as new treatment modalities are explored and tested. The following intravenous infusions used to treat the aforementioned chronic pain conditions will be reviewed: lidocaine, ketamine, phentolamine, dexmedetomidine, and bisphosphonates. This overview is intended to familiarize the practitioner with the variety of infusions for patients with chronic pain. It will not, however, be able to provide guidelines for their use due to the lack of sufficient evidence.

  18. Propofol infusion syndrome in refractory status epilepticus.

    Science.gov (United States)

    Hwang, Woo Sub; Gwak, Hye Min; Seo, Dae-Won

    2013-06-01

    Propofol is used for treating refractory status epilepticus, which has high rate of mortality. Propofol infusion syndrome is a rare but often fatal syndrome, characterized by lactic acidosis, lipidemia, and cardiac failure, associated with propofol infusion over prolonged periods of time. We investigated the clinical factors that characterize propofol infusion syndrome to know the risk of them in refractory status epilepticus. This retrospective observation study was conducted in Samsung medical center from Jan. 2005 to Dec. 2009. Thirty two patients (19 males, 13 females, aged between 16 and 64 years), with refractory status epilepsy were included. Their clinical findings and treatment outcomes were evaluated retrospectively. We divided our patients into established status epilepticus (ESE) and refractory status epilepticus (RSE). And then the patients with RSE was further subdivided into propofol treatment group (RSE-P) and the other anesthetics treatment group (RSE-O). We analyzed the clinical characteristics by comparison of the groups. There were significant differences of hypotension and lipid change between ESE and RSE (pRSE-P and RSE-O groups. The hospital days were longer in RSE than in ESE (p=0.012) and treatment outcome was also worse in RSE than in ESE (p=0.007) but there were no significant differences of hospital stays and treatment outcome between RSE-P and RSE-O. RSE is very critical disease with high mortality, which may show as many clinical changes as propofol infusion syndrome. Therefore propofol infusion syndrome might be considered as one of the clinical manifestations of RSE.

  19. Remotely Adjustable Hydraulic Pump

    Science.gov (United States)

    Kouns, H. H.; Gardner, L. D.

    1987-01-01

    Outlet pressure adjusted to match varying loads. Electrohydraulic servo has positioned sleeve in leftmost position, adjusting outlet pressure to maximum value. Sleeve in equilibrium position, with control land covering control port. For lowest pressure setting, sleeve shifted toward right by increased pressure on sleeve shoulder from servovalve. Pump used in aircraft and robots, where hydraulic actuators repeatedly turned on and off, changing pump load frequently and over wide range.

  20. Velocity selective optical pumping

    OpenAIRE

    Aminoff, C. G.; Pinard, M.

    1982-01-01

    We consider optical pumping with a quasi monochromatic tunable light beam, in the low intensity limit where a rate equation regime is obtained The velocity selective optical pumping (V.S.O.P.) introduces a correlation between atomic velocity and internal variables in the ground (or metastable) state. The aim of this article is to evaluate these atomic observables (orientation, alignment, population) as a function of velocity, using a phenomenological description of the relaxation effect of co...

  1. Lunar Base Heat Pump

    Science.gov (United States)

    Walker, D.; Fischbach, D.; Tetreault, R.

    1996-01-01

    The objective of this project was to investigate the feasibility of constructing a heat pump suitable for use as a heat rejection device in applications such as a lunar base. In this situation, direct heat rejection through the use of radiators is not possible at a temperature suitable for lde support systems. Initial analysis of a heat pump of this type called for a temperature lift of approximately 378 deg. K, which is considerably higher than is commonly called for in HVAC and refrigeration applications where heat pumps are most often employed. Also because of the variation of the rejection temperature (from 100 to 381 deg. K), extreme flexibility in the configuration and operation of the heat pump is required. A three-stage compression cycle using a refrigerant such as CFC-11 or HCFC-123 was formulated with operation possible with one, two or three stages of compression. Also, to meet the redundancy requirements, compression was divided up over multiple compressors in each stage. A control scheme was devised that allowed these multiple compressors to be operated as required so that the heat pump could perform with variable heat loads and rejection conditions. A prototype heat pump was designed and constructed to investigate the key elements of the high-lift heat pump concept. Control software was written and implemented in the prototype to allow fully automatic operation. The heat pump was capable of operation over a wide range of rejection temperatures and cooling loads, while maintaining cooling water temperature well within the required specification of 40 deg. C +/- 1.7 deg. C. This performance was verified through testing.

  2. Preservation of neuromuscular function in symptomatic SOD1-G93A mice by peripheral infusion of methylene blue.

    Science.gov (United States)

    Talbot, Janet D; Barrett, John N; Nonner, Doris; Zhang, Zhongsheng; Wicomb, Kyle; Barrett, Ellen F

    2016-11-01

    In mutant superoxide dismutase 1 (SOD1) mouse models of familial amyotrophic lateral sclerosis (fALS) some of the earliest signs of morphological and functional damage occur in the motor nerve terminals that innervate fast limb muscles. This study tested whether localized peripheral application of a protective drug could effectively preserve neuromuscular junctions in late-stage disease. Methylene blue (MB), which has mitochondria-protective properties, was infused via an osmotic pump into the anterior muscle compartment of one hind limb of late pre- symptomatic SOD1-G93A mice for ≥3weeks. When mice reached end-stage disease, peak twitch and tetanic contractions evoked by stimulation of the muscle nerve were measured in two anterior compartment muscles (tibialis anterior [TA] and extensor digitorum longus [EDL], both predominantly fast muscles). With 400μM MB in the infusion reservoir, muscles on the MB-infused side exhibited on average a ~100% increase in nerve-evoked contractile force compared to muscles on the contralateral non-infused side (p<0.01 for both twitch and tetanus in EDL and TA). Pairwise comparisons of endplate innervation also revealed a beneficial effect of MB infusion, with an average of 65% of endplates innervated in infused EDL, compared to only 35% on the non-infused side (p<0.01). Results suggested that MB's protective effects required an extracellular [MB] of ~1μM, were initiated peripherally (no evidence of retrograde transport into the spinal cord), and involved MB's reduced form. Thus peripherally-initiated actions of MB can help preserve neuromuscular structure and function in SOD1-G93A mice, even at late stages of disease. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Marrow Stromal Cell Infusion Rescues Hematopoiesis in Lethally Irradiated Mice despite Rapid Clearance after Infusion

    Directory of Open Access Journals (Sweden)

    Xiaodong Yang

    2012-01-01

    Full Text Available Marrow stromal cells (MSCs, also termed mesenchymal stem cells have been proposed as a promising cellular therapy for tissue injury including radiation-induced marrow failure, but evidence for a direct effect is lacking. To assess the effects of MSCs on survival after lethal irradiation, we infused syngeneic MSCs (either as immortalized MSCs clones or primary MSCs intravenously into wild-type C57/Bl6 mice within 24 hours of lethal total body irradiation (TBI. Mice receiving either of the MSC preparations had significantly improved survival when compared to controls. In vivo imaging, immune histochemistry, and RT-PCR employed to detect MSCs indicated that the infused MSCs were predominantly localized to the lungs and rapidly cleared following infusion. Our results suggest that a single infusion of MSCs can improve survival after otherwise lethal TBI but the effect is not due to a direct interaction with, or contribution to, the damaged marrow by MSCs.

  4. BIOMATERIALS FOR ROTARY BLOOD PUMPS

    NARCIS (Netherlands)

    VANOEVEREN, W

    1995-01-01

    Rotary blood pumps are used for cardiac assist and cardiopulmonary support since mechanical blood damage is less than with conventional roller pumps. The high shear rate in the rotary pump and the reduced anticoagulation of the patient during prolonged pumping enforces high demands on the biocompati

  5. Pumping a playground swing.

    Science.gov (United States)

    Post, Auke A; de Groot, Gert; Daffertshofer, Andreas; Beek, Peter J

    2007-04-01

    In mechanical studies of pumping a playground swing, two methods of energy insertion have been identified: parametric pumping and driven oscillation. While parametric pumping involves the systematic raising and lowering of the swinger's center of mass (CM) along the swing's radial axis (rope), driven oscillation may be conceived as rotation of the CM around a pivot point at a fixed distance to the point of suspension. We examined the relative contributions of those two methods of energy insertion by inviting 18 participants to pump a swing from standstill and by measuring and analyzing the swing-swinger system (defined by eight markers) in the sagittal plane. Overall, driven oscillation was found to play a major role and parametric pumping a subordinate role, although the relative contribution of driven oscillation decreased as swinging amplitude increased, whereas that of parametric pumping increased slightly. Principal component analysis revealed that the coordination pattern of the swing-swinger system was largely determined (up to 95%) by the swing's motion, while correlation analysis revealed that (within the remaining 5% of variance) trunk and leg rotations were strongly coupled.

  6. Suction characteristics of a thick material pump at high concentrations of coal slime

    Institute of Scientific and Technical Information of China (English)

    MA Xing-min; ZHAO Qiao-zhi; GAO Shao-gang; WU Miao

    2008-01-01

    A test system was designed to study the parameters affecting the volumetric efficiency of a thick-material pump for coal slime. The parameters studied included solid concentration, the slenderness ratio of the suction cylinder and the running speed of the hydraulic cylinder. In the experiment the concentrations of coal slime were 75.7%, 76.3%, 74.4%, 73.5%, 72.1% and 70.63%; the running speeds were 0.23, 0.18, 0.13, 0.10 and 0.08 m/s; and the slenderness ratios of the suction cylinder were 1.63, 2.26, 2.88, 3.50, 4.13, 4.78 and 5.38. The results show that the suction volumetric efficiency decreases gradually with an increase in material concentration. The critical concentration value is 72%; below 72% the suction volumetric efficiency is above 90%, otherwise it decreases rapidly. When the solid concentration reaches 76.3%, the suction volumetric efficiency is only 40%. When the running speed of the piston is less than or equal to 0.23 m/s, the suction volumetric efficiency increases with an increase in running speed.

  7. Thermally Actuated Hydraulic Pumps

    Science.gov (United States)

    Jones, Jack; Ross, Ronald; Chao, Yi

    2008-01-01

    Thermally actuated hydraulic pumps have been proposed for diverse applications in which direct electrical or mechanical actuation is undesirable and the relative slowness of thermal actuation can be tolerated. The proposed pumps would not contain any sliding (wearing) parts in their compressors and, hence, could have long operational lifetimes. The basic principle of a pump according to the proposal is to utilize the thermal expansion and contraction of a wax or other phase-change material in contact with a hydraulic fluid in a rigid chamber. Heating the chamber and its contents from below to above the melting temperature of the phase-change material would cause the material to expand significantly, thus causing a substantial increase in hydraulic pressure and/or a substantial displacement of hydraulic fluid out of the chamber. Similarly, cooling the chamber and its contents from above to below the melting temperature of the phase-change material would cause the material to contract significantly, thus causing a substantial decrease in hydraulic pressure and/or a substantial displacement of hydraulic fluid into the chamber. The displacement of the hydraulic fluid could be used to drive a piston. The figure illustrates a simple example of a hydraulic jack driven by a thermally actuated hydraulic pump. The pump chamber would be a cylinder containing encapsulated wax pellets and containing radial fins to facilitate transfer of heat to and from the wax. The plastic encapsulation would serve as an oil/wax barrier and the remaining interior space could be filled with hydraulic oil. A filter would retain the encapsulated wax particles in the pump chamber while allowing the hydraulic oil to flow into and out of the chamber. In one important class of potential applications, thermally actuated hydraulic pumps, exploiting vertical ocean temperature gradients for heating and cooling as needed, would be used to vary hydraulic pressures to control buoyancy in undersea research

  8. Insulin Pump and CGM Usage in the United States and Germany

    Science.gov (United States)

    Walsh, John; Roberts, Ruth; Weber, Dietmar; Faber-Heinemann, Gabriele; Heinemann, Lutz

    2015-01-01

    Background: This survey collected and evaluated user responses about routine tasks and preferences regarding insulin pumps and infusion sets (IIS) with comparison of intercountry differences between the United States (US) and Germany (GER), chosen for their large insulin pump populations. Methods: A total of 985 subjects (534 US, 451 GER; 60% female) with type 1 diabetes on pump therapy anonymously answered 20 pump-related questions. US subjects also answered 11 questions about continuous glucose monitoring (CGM) usage. Results: Length of use of insulin cartridges is shorter in US than in GER, mean (SD) 4.3 (5.0) versus 5.3 (3.2) days (P insulin cartridges (7.3% for >3 days vs 7.7% for pump wearers stated that they were “very satisfied” with their pump (49% US vs 45% GER, ns). However, 98% would recommend the pump to others (95% vs 93%, ns). Analysis of CGM questions showed that 297 (60%) of 496 US responders currently wore one. Of these, 84% said they would recommend CGM to others. CGM wearers who stated they were “very satisfied” with their CGM had lower HbA1c than those who said they were “partly satisfied” (6.9% vs 7.2%). Conclusions: This survey shows interesting differences in real-world use of insulin pumps in 2 large markets, and suggests areas where insulin pumps and CGMs might be improved. PMID:26071425

  9. A Micro-PIV Study of the Pulsed Micro-Flows Driven by an Insulin Pump

    Science.gov (United States)

    Wang, Bing; Demuren, Ayodeji; Gyuricsko, Eric; Hu, Hui

    2009-11-01

    In recent years, there is a surge in the popularity of using insulin pump or continuous subcutaneous insulin infusion therapy, as opposed to multiple daily injections by insulin syringe or an insulin pen. Some case studies have suggested that insulin delivery failure may be caused by precipitation of insulin within the infusion set. Speculation also exists that the flow of insulin through an insulin infusion set may be reduced or inhibited by air bubbles entrained into the micro-sized tubing system since there are chances that air be introduced into the insulin reservoir during the filling process. In the present study, a microscopic Particle Image Velocimtry (micro-PIV) system was used to characterize the transient behavior of the pulsed micro-flows inside the micro-sized tubing system of an insulin infusion set with insulin pump operating in basal mode (i.e., pulsed insulin pumping). The effects of the air bubbles entrained into the micro-sized tubing system on the insulin delivery process were assessed based on the micro-PIV measurements.

  10. An audit of hospital based outpatient infusions and a pilot program of community-based monoclonal antibody infusions.

    LENUS (Irish Health Repository)

    Doran, J-P

    2012-02-01

    INTRODUCTION: Infliximab, a chimeric monoclonal antibody to tumour necrosis factor alpha, is administered as an intravenous infusion requiring a costly hospital day case or inpatient admission. METHODS: An audit of all current therapies given by intravenous infusions in an outpatient setting in St Vincent\\'s University Hospital (SVUH) was undertaken. Furthermore, in conjunction with TCP homecare, we established in a general practise health clinic, the first Irish community infusion centre for the administration of infliximab in August 2006. RESULTS: All outpatient departments indicated that they would favour a centralized hospital infusion unit. There were no adverse events and the mean global satisfaction improved in the community infliximab infusion pilot programme of seven patients. CONCLUSION: This study suggests efficiencies in providing centralized infusion facilities, while the community based infusion of infliximab is feasible and safe in this small cohort and identifies the community infusion unit as a viable and cost efficient alternative for administration of infliximab.

  11. Electronic Unit Pump Test Bench Development and Pump Properties Research

    Institute of Scientific and Technical Information of China (English)

    LIU Bo-lan; HUANG Ying; ZHANG Fu-jun; ZHAO Chang-lu

    2006-01-01

    A unit pump test bench is developed on an in-line pump test platform. The bench is composed of pump adapting assembly, fuel supply subsystem, lubricating subsystem and a control unit. A crank angle domain injection control method is given out and the control accuracy can be 0.1° crank degree. The bench can test bot h mechanical unit pump and electronic unit pump. A test model-PLD12 electronic unit pump is tested. Full pump delivery map and some influence factors test is d one. Experimental results show that the injection quantity is linear with the de livery angle. The quantity change rate is 15% when fuel temperature increases 30℃. The delivery quantity per cycle increases 30mg at 28V drive voltage. T he average delivery difference for two same type pumps is 5%. Test results show that the bench can be used for unit pump verification.

  12. Space-Time Transfinite Interpolation of Volumetric Material Properties.

    Science.gov (United States)

    Sanchez, Mathieu; Fryazinov, Oleg; Adzhiev, Valery; Comninos, Peter; Pasko, Alexander

    2015-02-01

    The paper presents a novel technique based on extension of a general mathematical method of transfinite interpolation to solve an actual problem in the context of a heterogeneous volume modelling area. It deals with time-dependent changes to the volumetric material properties (material density, colour, and others) as a transformation of the volumetric material distributions in space-time accompanying geometric shape transformations such as metamorphosis. The main idea is to represent the geometry of both objects by scalar fields with distance properties, to establish in a higher-dimensional space a time gap during which the geometric transformation takes place, and to use these scalar fields to apply the new space-time transfinite interpolation to volumetric material attributes within this time gap. The proposed solution is analytical in its nature, does not require heavy numerical computations and can be used in real-time applications. Applications of this technique also include texturing and displacement mapping of time-variant surfaces, and parametric design of volumetric microstructures.

  13. In Vivo Real Time Volumetric Synthetic Aperture Ultrasound Imaging

    DEFF Research Database (Denmark)

    Bouzari, Hamed; Rasmussen, Morten Fischer; Brandt, Andreas Hjelm;

    2015-01-01

    Synthetic aperture (SA) imaging can be used to achieve real-time volumetric ultrasound imaging using 2-D array transducers. The sensitivity of SA imaging is improved by maximizing the acoustic output, but one must consider the limitations of an ultrasound system, both technical and biological...

  14. Automatic segmentation of pulmonary segments from volumetric chest CT scans.

    NARCIS (Netherlands)

    Rikxoort, E.M. van; Hoop, B. de; Vorst, S. van de; Prokop, M.; Ginneken, B. van

    2009-01-01

    Automated extraction of pulmonary anatomy provides a foundation for computerized analysis of computed tomography (CT) scans of the chest. A completely automatic method is presented to segment the lungs, lobes and pulmonary segments from volumetric CT chest scans. The method starts with lung segmenta

  15. Volumetric T-spline Construction Using Boolean Operations

    Science.gov (United States)

    2013-07-01

    15213, USA 2 Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX 78712, USA 3 Department of Civil and...and S. Yau. Volumetric harmonic map. Communications in Information and Systems, 3(3):191–202, 2003. 12. C.A.R. Guerra . Simultaneous untangling and

  16. Volumetric motion quantification by 3D tissue phase mapped CMR

    Directory of Open Access Journals (Sweden)

    Lutz Anja

    2012-10-01

    Full Text Available Abstract Background The objective of this study was the quantification of myocardial motion from 3D tissue phase mapped (TPM CMR. Recent work on myocardial motion quantification by TPM has been focussed on multi-slice 2D acquisitions thus excluding motion information from large regions of the left ventricle. Volumetric motion assessment appears an important next step towards the understanding of the volumetric myocardial motion and hence may further improve diagnosis and treatments in patients with myocardial motion abnormalities. Methods Volumetric motion quantification of the complete left ventricle was performed in 12 healthy volunteers and two patients applying a black-blood 3D TPM sequence. The resulting motion field was analysed regarding motion pattern differences between apical and basal locations as well as for asynchronous motion pattern between different myocardial segments in one or more slices. Motion quantification included velocity, torsion, rotation angle and strain derived parameters. Results All investigated motion quantification parameters could be calculated from the 3D-TPM data. Parameters quantifying hypokinetic or asynchronous motion demonstrated differences between motion impaired and healthy myocardium. Conclusions 3D-TPM enables the gapless volumetric quantification of motion abnormalities of the left ventricle, which can be applied in future application as additional information to provide a more detailed analysis of the left ventricular function.

  17. Video-rate volumetric optical coherence tomography-based microangiography

    Science.gov (United States)

    Baran, Utku; Wei, Wei; Xu, Jingjiang; Qi, Xiaoli; Davis, Wyatt O.; Wang, Ruikang K.

    2016-04-01

    Video-rate volumetric optical coherence tomography (vOCT) is relatively young in the field of OCT imaging but has great potential in biomedical applications. Due to the recent development of the MHz range swept laser sources, vOCT has started to gain attention in the community. Here, we report the first in vivo video-rate volumetric OCT-based microangiography (vOMAG) system by integrating an 18-kHz resonant microelectromechanical system (MEMS) mirror with a 1.6-MHz FDML swept source operating at ˜1.3 μm wavelength. Because the MEMS scanner can offer an effective B-frame rate of 36 kHz, we are able to engineer vOMAG with a video rate up to 25 Hz. This system was utilized for real-time volumetric in vivo visualization of cerebral microvasculature in mice. Moreover, we monitored the blood perfusion dynamics during stimulation within mouse ear in vivo. We also discussed this system's limitations. Prospective MEMS-enabled OCT probes with a real-time volumetric functional imaging capability can have a significant impact on endoscopic imaging and image-guided surgery applications.

  18. Clinical review: insulin pump-associated adverse events in adults and children.

    Science.gov (United States)

    Ross, P L; Milburn, J; Reith, D M; Wiltshire, E; Wheeler, B J

    2015-12-01

    Insulin pumps are a vital and rapidly developing tool in the treatment of type 1 diabetes mellitus in both adults and children. Many studies have highlighted outcomes and assessed their potential advantages, but much of the data on adverse outcomes are limited and often based on outdated technology. We aimed to review and summarize the available literature on insulin pump-associated adverse events in adults and children. A literature search was undertaken using PubMed, EMBASE, and the Cochrane library. Articles were then screened by title, followed by abstract, and full text as needed. A by-hand search of reference lists in identified papers was also utilised. All searches were limited to English language material, but no time limits were used. Current and past literature regarding insulin pump-associated adverse events is discussed, including potential metabolic and non-metabolic adverse events, in particular: pump malfunction; infusion set/site issues; and cutaneous problems. We show that even with modern technology, adverse events are common, occurring in over 40 % of users per year, with a minority, particularly in children, requiring hospital management. Hyperglycaemia and ketosis are now the most common consequences of adverse events and are usually associated with infusion set failure. This differs from older technology where infected infusion sites predominated. This timely review covers all potential insulin pump-associated adverse events, including their incidence, features, impacts, and contributory factors such as the pump user. The importance of ongoing anticipatory education and support for patients and families using this intensive insulin technology is highlighted, which if done well should improve the overall experience of pump therapy for users, and hopefully reduce the incidence and impact of severe adverse events.

  19. Continual Low-Dose Infusion of Sulfamidase Is Superior to Intermittent High-Dose Delivery in Ameliorating Neuropathology in the MPS IIIA Mouse Brain.

    Science.gov (United States)

    Beard, Helen; Hassiotis, Sofia; Luck, Amanda J; Rozaklis, Tina; Hopwood, John J; Hemsley, Kim M

    2016-01-01

    Mucopolysaccharidosis IIIA (MPS IIIA) is a neurodegenerative lysosomal storage disorder characterised by progressive loss of learned skills, sleep disturbance and behavioural problems. Reduced activity of lysosomal sulfamidase results in accumulation of heparan sulfate and secondary storage of glycolipids in the brain. Intra-cisternal sulfamidase infusions reduce disease-related neuropathology; however, repeated injections may subject patients to the risk of infection and tissue damage so alternative approaches are required. We undertook a proof-of-principle study comparing the ability of slow/continual or repeat/bolus infusion to ameliorate neuropathology in MPS IIIA mouse brain. Six-week-old MPS IIIA mice were implanted with subcutaneously located mini-osmotic pumps filled with recombinant human sulfamidase (rhSGSH) or vehicle, connected to lateral ventricle-directed cannulae. Pumps were replaced at 8 weeks of age. Additional MPS IIIA mice received intra-cisternal bolus infusions of the same amount of rhSGSH (or vehicle), at 6 and 8 weeks of age. Unaffected mice received vehicle via each strategy. All mice were euthanised at 10 weeks of age and the brain was harvested to assess the effect of treatment on neuropathology. Mice receiving pump-delivered rhSGSH exhibited highly significant reductions in lysosomal storage markers (lysosomal integral membrane protein-2, GM3 ganglioside and filipin-positive lipids) and neuroinflammation (isolectin B4-positive microglia, glial fibrillary acidic protein-positive astroglia). MPS IIIA mice receiving rhSGSH via bolus infusion displayed reductions in these markers, but the effectiveness of the strategy was inferior to that seen with slow/pump-based delivery. Continual low-dose infusion may therefore be a more effective strategy for enzyme delivery in MPS IIIA.

  20. Safety of Continuous Infusion Ketorolac in Postoperative Coronary Artery Bypass Graft Surgery Patients

    Directory of Open Access Journals (Sweden)

    Meredith L. Howard

    2016-06-01

    Full Text Available Background:Continuous infusion ketorolac is sometimes utilized for analgesia in postoperative coronary artery bypass graft (CABG patients despite contraindications for use. Limited literature surrounds this topic; therefore, this study was conducted to evaluate the safety of this practice. Methods: This retrospective cohort study evaluated the primary outcome of mortality and secondary outcomes of incidence of bleeding and myocardial infarction (MI. All patients who underwent isolated CABG surgeries and received continuous infusion ketorolac during the study period were included. An equal number of randomly selected isolated CABG patients served as control patients. Electronic medical records and the Society of Thoracic Surgeons (STS database were utilized to determine baseline characteristics and outcomes; Results: One hundred and seventy-eight patients met inclusion; 89 in each group. More patients in the control group underwent on-pump surgeries (78.6% vs. 29.2%, p = 0.01 and had higher STS risk scores (1.1% vs. 0.6%, p = 0.003. There was no difference in mortality between the ketorolac group and control group (2.2% vs. 3.3%, p = 0.605. Additionally, no patients experienced a MI and there was no difference in bleeding incidence (5.5% vs. 6.7%, p = 0.58; Conclusions: No association was found between continuous infusion ketorolac and increased risk of mortality, MI, or bleeding events in postoperative CABG patients. Considerations to differences in baseline characteristics must be made when interpreting results.

  1. [Determination of residual cyclohexanone in disposable infusion set by gas chromatography].

    Science.gov (United States)

    Zhang, Li; Wen, Yan; He, Tao; Wang, Minzhu; Xu, Pinghua

    2014-09-01

    An effective GC method was established for contents determination of the residual solvent of cyclohexanone in infusion sets for single use. The cyclohexanone in infusion sets for single use products were extracted with circular pump, using ethylalcohol as the extraction solven, then the extract followed by analysis of gas chromatography-tandem mass spectrometry. The method was simple, rapid, sensitive and accurate, Cyclohexanone showed good linearity in the range of (5.5-190.9) μg/mL, the correlation coefficient was 0.999 0, the detection limit (S/N = 3) was 0.133 μg/mL and limits of quantitation (S/N = 10) was 1.33 μg/mL. The spiked average recoveries ranged from 98% to 99%. The relative standard deviations (RSDs) of the method ranged from 1.03% to 1.98%. The method was simple, fast, sensitive and accurate, and may serve as a mass control method for residual cyclohexanone in disposable infusion sets for single use.

  2. Software Engineering Technology Infusion Within NASA

    Science.gov (United States)

    Zelkowitz, Marvin V.

    1996-01-01

    Abstract technology transfer is of crucial concern to both government and industry today. In this paper, several software engineering technologies used within NASA are studied, and the mechanisms, schedules, and efforts at transferring these technologies are investigated. The goals of this study are: 1) to understand the difference between technology transfer (the adoption of a new method by large segments of an industry) as an industry-wide phenomenon and the adoption of a new technology by an individual organization (called technology infusion); and 2) to see if software engineering technology transfer differs from other engineering disciplines. While there is great interest today in developing technology transfer models for industry, it is the technology infusion process that actually causes changes in the current state of the practice.

  3. Software Engineering Technology Infusion Within NASA

    Science.gov (United States)

    Zelkowitz, Marvin V.

    1996-01-01

    Abstract technology transfer is of crucial concern to both government and industry today. In this paper, several software engineering technologies used within NASA are studied, and the mechanisms, schedules, and efforts at transferring these technologies are investigated. The goals of this study are: 1) to understand the difference between technology transfer (the adoption of a new method by large segments of an industry) as an industry-wide phenomenon and the adoption of a new technology by an individual organization (called technology infusion); and 2) to see if software engineering technology transfer differs from other engineering disciplines. While there is great interest today in developing technology transfer models for industry, it is the technology infusion process that actually causes changes in the current state of the practice.

  4. Analysis of Changing Swarm Rate using Volumetric Strain

    Science.gov (United States)

    Kumazawa, T.; Ogata, Y.; Kimura, K.; Maeda, K.; Kobayashi, A.

    2015-12-01

    Near the eastern coast of Izu peninsula is an active submarine volcanic region in Japan, where magma intrusions have been observed many times. The forecast of earthquake swarm activities and eruptions are serious concern particularly in nearby hot spring resort areas. It is well known that temporal durations of the swarm activities have been correlated with early volumetric strain changes at a certain observation station of about 20 km distance apart. Therefore the Earthquake Research Committee (2010) investigated some empirical statistical relations to predict sizes of the swarm activity. Here we looked at the background seismicity rate changes during these swarm periods using the non-stationary ETAS model (Kumazawa and Ogata, 2013, 2014), and have found the followings. The modified volumetric strain data, by removing the effect of earth tides, precipitation and coseismic jumps, have significantly higher cross-correlations to the estimated background rates of the ETAS model than to the swarm rate-changes. Specifically, the background seismicity rate synchronizes clearer to the strain change by the lags around a half day. These relations suggest an enhanced prediction of earthquakes in this region using volumetric strain measurements. Hence we propose an extended ETAS model where the background rate is modulated by the volumetric strain data. We have also found that the response function to the strain data can be well approximated by an exponential functions with the same decay rate, but that their intersects are inversely proportional to the distances between the volumetric strain-meter and the onset location of the swarm. Our numerical results by the same proposed model show consistent outcomes for the various major swarms in this region.

  5. Heat driven pulse pump

    Science.gov (United States)

    Benner, Steve M (Inventor); Martins, Mario S. (Inventor)

    2000-01-01

    A heat driven pulse pump includes a chamber having an inlet port, an outlet port, two check valves, a wick, and a heater. The chamber may include a plurality of grooves inside wall of the chamber. When heated within the chamber, a liquid to be pumped vaporizes and creates pressure head that expels the liquid through the outlet port. As liquid separating means, the wick, disposed within the chamber, is to allow, when saturated with the liquid, the passage of only liquid being forced by the pressure head in the chamber, preventing the vapor from exiting from the chamber through the outlet port. A plurality of grooves along the inside surface wall of the chamber can sustain the liquid, which is amount enough to produce vapor for the pressure head in the chamber. With only two simple moving parts, two check valves, the heat driven pulse pump can effectively function over the long lifetimes without maintenance or replacement. For continuous flow of the liquid to be pumped a plurality of pumps may be connected in parallel.

  6. Superselective arterial infusion and concomitant radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Homma, Akihiro; Suzuki, Fumiyuki; Inuyama, Yukio; Fukuda, Satoshi [Hokkaido Univ., Sapporo (Japan). School of Medicine

    2003-05-01

    Superselective arterial infusion for patients with advanced head and neck cancer has been increasingly applied in Japan. We analyzed our experiences and evaluated the efficacy and safety of this treatment. Through October 1999 to March 2002, 29 patients, ranging in age between 33 and 71 years (median 52 years), received superselective intra-arterial infusion therapy of cisplatin (100-120 mg/m{sup 2}/week) with simultaneous intravenous infusion of thiosulfate for neutralizing cisplatin toxicity, and conventional concomitant extrabeam radiotherapy (65 Gy/26 f/6.5 weeks). Four patients were diagnosed with stage III and 25 with stage IV. Thirteen patients were considered contraindicated for surgery, and the other 16 patients rejected radical surgery. Primary tumor sites included paranasal sinus (11 patients), hypopharynx (7), oropharynx (6), oral cavity (4), and parotid gland (1). During the median follow-up period of 20 months, there was no apparent recurrence in 14 (48.3%) of 29 patients. Eleven (37.9%) patients died of disease, and three (10.3%) were alive with disease. In twenty-one patients (72.4%) the primary lesions were well-controlled. Acute toxic effects were moderate, and severe toxic events occurred in four cases, namely, methicillin-resistant staphylococcus aureus (MRSA) pneumonia, sepsis, tetraplasia, and osteoradionecrosis. We confirmed the effectiveness and safety of superselective arterial infusion and concomitant radiotherapy. Furthermore, we must establish the optimal procedures and schedule, as well as the indications for this treatment. This treatment protocol may improve the prognosis of patients with unresectable disease and patients rejecting surgical treatment. Further study in this particular area is needed. (author)

  7. Analysis of the vacuum infusion moulding process

    OpenAIRE

    Correia, Nuno André Curado Mateus

    2004-01-01

    This thesis focuses on flow through compliant porous media with applications to the manufacturing of composites by vacuum infusion (VI). The context of this work is the need for reliability in environmentally friendly composite processing methods for composite materials. Commercial reality and the prospective application to low cost structures for the transportation industry dictate that appropriate emphasis should be put on obtaining robust simulations, ensuring reliability and progressing t...

  8. Safe intravenous administration in pediatrics: A 5-year Pediatric Intensive Care Unit experience with smart pumps.

    Science.gov (United States)

    Manrique-Rodríguez, S; Sánchez-Galindo, A C; Fernández-Llamazares, C M; Calvo-Calvo, M M; Carrillo-Álvarez, Á; Sanjurjo-Sáez, M

    2016-10-01

    To estimate the impact of smart pump implementation in a pediatric intensive care unit in terms of number and type of administration errors intercepted. Observational, prospective study carried out from January 2010 to March 2015 with syringe and great volumen infusion pumps available in the hospital. A tertiary level hospital pediatric intensive care unit. Infusions delivered with infusion pumps in all pediatric intensive care unit patients. Design of a drug library with safety limits for all intravenous drugs prescribed. Users' compliance with drug library as well as number and type of errors prevented were analyzed. Two hundred and eighty-three errors were intercepted during 62 months of study. A high risk drug was involved in 58% of prevented errors, such as adrenergic agonists and antagonists, sedatives, analgesics, neuromuscular blockers, opioids, potassium and insulin. Users' average compliance with the safety software was 84%. Smart pumps implementation has proven effective in intercepting high risk drugs programming errors. These results might be exportable to other critical care units, involving pediatric or adult patients. Interdisciplinary colaboration is key to succeed in this process. Copyright © 2016 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.

  9. Design of Infusion Schemes for Neuroreceptor Imaging

    DEFF Research Database (Denmark)

    Feng, Ling; Svarer, Claus; Madsen, Karine;

    2016-01-01

    for bolus infusion (BI) or programmed infusion (PI) experiments. Steady-state quantitative measurements can be made with one short scan and venous blood samples. The GABAA receptor ligand [(11)C]Flumazenil (FMZ) was chosen for this purpose, as it lacks a suitable reference region. Methods. Five bolus [(11)C......]FMZ-PET scans were conducted, based on which population-based PI and BI schemes were designed and tested in five additional healthy subjects. The design of a PI was assisted by an offline feedback controller. Results. The system could reproduce the measurements in blood and brain. With PI, [(11)C]FMZ steady...... state was attained within 40 min, which was 8 min earlier than the optimal BI (B/I ratio = 55 min). Conclusions. The system can design both BI and PI schemes to attain steady state rapidly. For example, subjects can be [(11)C]FMZ-PET scanned after 40 min of tracer infusion for 40 min with venous...

  10. Propionate uptake by rumen microorganisms: the effect of ruminal infusion

    OpenAIRE

    Nozière, P; Gachon, S.; DOREAU, M.

    2003-01-01

    International audience; We assessed the ability of rumen microbes to significantly incorporate propionate when they are subjected in vivo to no infusion, long-term infusion of minerals, and short- and long-term infusion of high amounts of propionate. Four ruminally cannulated sheep fed 1000 g hay (8 meals per d) were used in a $4 \\times 4$ Latin square design. The treatments consisted of no infusion (C), ruminal infusion of propionate (86 g$\\cdot$d$^{-1}$) for 1 (P1) and 7 d (P7), and of mine...

  11. Developing a drug library for smart pumps in a pediatric intensive care unit.

    Science.gov (United States)

    Manrique-Rodríguez, Silvia; Sánchez-Galindo, Amelia; Fernández-Llamazares, Cecilia M; López-Herce, Jesús; García-López, Isabel; Carrillo-Álvarez, Angel; Sanjuro-Sáez, María

    2012-03-01

    The most serious medication errors occur during intravenous administration. The potential consequences are more serious the more critical and younger the patient. Smart pumps can help to prevent infusion-related programming errors, thanks to associated dose-limiting software known as "drug library". Drug libraries alert the user if pre-determined high dosage limits are exceeded or if entry is below pre-determined low dosage limits. To describe the process for developing a specific drug library for a pediatric intensive care unit (PICU) and the key factors for preventing programming errors. The study was performed by a multidisciplinary team consisting of a clinical pharmacist, a PICU pediatrician, and the chief nurse of the unit. The process of developing the drug library lasted seven months. A literature review was carried out to determine standard concentrations and accurate limits for intravenous administration of high-risk drugs. Alaris(®) syringe pumps and Guardrails(®) CQI v4.1 Event Reporter software were used. Several manufacturers offer smart pump technology. Users should be aware of differences in features, such as definition of parameters and associations between them, definition of safety limits, organization of the drug library, and data use. Our infusion pump technology covered 108 drugs. Compliance with the drug library was 85% and nurses' acceptance of the drug library was high as 94% would recommend implementation of this technology in other units. After nine months of implementation, several potentially harmful infusion-related programming errors were intercepted. Drug libraries are specifically designed for a particular hospital unit, and may condition the success in implementing this technology. Implementation of smart pumps proved effective in intercepting infusion-related programming errors after nine months of implementation in a PICU. Copyright © 2011 Elsevier B.V. All rights reserved.

  12. Intravenous proton pump inhibitors for peptic ulcer bleeding: Clinical benefits and limits.

    Science.gov (United States)

    Cheng, Hsiu-Chi; Sheu, Bor-Shyang

    2011-03-16

    Peptic ulcer bleeding is a common disease and recurrent bleeding is an independent risk factor of mortality. Infusion with proton pump inhibitors (PPIs) prevents recurrent bleeding after successful endoscopic therapy. A gastric acidic environment of less than pH 5.4 alters coagulation function and activates pepsin to disaggregate platelet plugs. Gastric acid is secreted by H(+), K(+)-ATPase, naming the proton pump. This update review focuses on the mechanism and the role of PPIs in the clinical management of patients with peptic ulcer bleeding. An intravenous omeprazole bolus followed by high-dose continuous infusion for 72 h after successful endoscopic therapy can prevent the recurrent bleeding. In the Asian, however, the infusion dosage can possibly be diminished whilst preserving favorable control of the intragastric pH and thereby still decreasing rates of recurrent bleeding. Irrespective of the infusion dosage of PPIs, rates of recurrent bleeding remain high in patients with co-morbidities. Because recurrent peptic ulcer bleeding may be prolonged in those with co-morbidities, a low-dose infusion of IV PPIs for up to 7-day may result in better control of recurrent bleeding of peptic ulcers. Due to the inter-patient variability in CYP2C19 genotypes, the infusion form of new generation PPIs, such as esomeprazole, should be promising for the prevention of recurrent bleeding. This article offers a comprehensive review of clinical practice, highlighting the indication, the optimal dosage, the duration, and the potential limitation of PPIs infusion for peptic ulcer bleeding.

  13. Effect of Insulin Infusion on Liver Protein Synthesis during Hemodialysis

    DEFF Research Database (Denmark)

    Reinhard, Mark; Frystyk, Jan; Jespersen, Bente

    2011-01-01

    Background Hemodialysis (HD) is a catabolic procedure that may contribute to the high frequency of protein-energy wasting among patients receiving maintenance HD. The present study investigated the additional effect of glucose and glucose-insulin infusion on liver protein synthesis during HD...... compared with a meal alone. Methods In a randomized cross-over study with three arms, 11 non-diabetic HD patients were assigned to receive a conventional HD session with either: • no treatment (NT) • IV infusion of glucose (G) • IV infusion of glucose-insulin (GI) During infusions blood glucose levels were...... maintained at 8.0-10.0 mmol/L by additional glucose infusion. Glucose and glucose-insulin infusions were commenced 2 h prior to HD and continued throughout the HD session. Fasting blood samples were collected at baseline before infusion and followed by the only meal allowed during the study. Results Blood...

  14. Oil-Infused Superhydrophobic Silicone Material for Low Ice Adhesion with Long-Term Infusion Stability.

    Science.gov (United States)

    Yeong, Yong Han; Wang, Chenyu; Wynne, Kenneth J; Gupta, Mool C

    2016-11-23

    A new approach for anti-icing materials was created to combat the effects of ice accretion and adhesion. The concept combines the strengths of individual characteristics for low ice adhesion based on elasticity, superhydrophobicity, and slippery liquid infused porous surfaces (SLIPS) for an optimal combination of high water repellency and ice-phobicity. This was achieved by replicating microtextures from a laser-irradiated aluminum substrate to an oil-infused polydimethylsiloxane (PDMS) elastomer, the result of which is a flexible, superhydrophobic, and lubricated material. This design provides multiple strategies of icing protection through high water repellency to retard ice accretion and with elasticity and oil infusion for low ice adhesion in a single material. Studies showed that an infusion of silicone oils with viscosity at 100 cSt and below 8 wt % in PDMS solution is sufficient to reduce the ice shear strength to an average of 38 kPa while maintaining contact angles and roll-off angles of above 150° and below 10°, respectively. This ice-adhesion value is a ∼95% reduction from a bare aluminum surface and ∼30% reduction from a microtextured, superhydrophobic PDMS material without oil infusion. In addition, three-month aging studies showed that the wetting and ice-adhesion performance of this material did not significantly degrade.

  15. Pulsed differential pumping system

    Energy Technology Data Exchange (ETDEWEB)

    Antipov, G.N.; Bagautdinov, F.A.; Rybalov, S.V.

    1985-06-01

    A pulsed differential pumping system is described for extracting an electron beam from a shaping region at a pressure of 10/sup -5/ torr into a volume with a pressure of 10-100 torr. A fast valve is used with appropriate geometrical parameters to reduce the length of the outlet channel considerable while increasing its diameter. Test results are given. The pumping system has two sections which communicate one with the other and with the volume at the elevated pressure which is produced by gasdynamic nozzles.

  16. Heat pump planning handbook

    CERN Document Server

    Bonin, Jürgen

    2015-01-01

    The Heat Pump Planning Handbook contains practical information and guidance on the design, planning and selection of heat pump systems, allowing engineers, designers, architects and construction specialists to compare a number of different systems and options. Including detailed descriptions of components and their functions and reflecting the current state of technology this guide contains sample tasks and solutions as well as new model calculations and planning evaluations. Also economic factors and alternative energy sources are covered, which are essential at a time of rising heat costs. T

  17. Sorption product heat pump

    Energy Technology Data Exchange (ETDEWEB)

    Antonini, G.; Francois, O.; Gendarme, J.P.; Guilleminot, J.J.; Meunier, F.

    1988-07-15

    A continuous operating, and thus with enhanced performance, heat pump is presented. In this heat pump, the heat transfer between the hot source and the output system or network is realized through a solid adsorbent-refrigerant couple having endothermal desorption properties and exothermal adsorption or absorption properties. The sorption products are carried in a closed cycle movement between the two parts of the reactor. Each side of the reactor is assuming always the same function and the thermal inertia have to be overcome only when starting the reactor.

  18. Regenerative adsorbent heat pump

    Science.gov (United States)

    Jones, Jack A. (Inventor)

    1991-01-01

    A regenerative adsorbent heat pump process and system is provided which can regenerate a high percentage of the sensible heat of the system and at least a portion of the heat of adsorption. A series of at least four compressors containing an adsorbent is provided. A large amount of heat is transferred from compressor to compressor so that heat is regenerated. The process and system are useful for air conditioning rooms, providing room heat in the winter or for hot water heating throughout the year, and, in general, for pumping heat from a lower temperature to a higher temperature.

  19. Geothermal Heat Pump Performance

    Energy Technology Data Exchange (ETDEWEB)

    Boyd, Tonya L.; Lienau, Paul J.

    1995-01-01

    Geothermal heat pump systems are a promising new energy technology that has shown rapid increase in usage over the past ten years in the United States. These systems offer substantial benefits to customers and utilities in energy (kWh) and demand (kW) savings. The purpose of this study was to determine what existing monitored data was available mainly from electric utilities on heat pump performance, energy savings and demand reduction for residential, school, and commercial building applications. Information was developed on the status of electric utility marketing programs, barriers to market penetration, incentive programs, and benefits.

  20. Geothermal heat pump performance

    Energy Technology Data Exchange (ETDEWEB)

    Boyd, Tonya L.; Lienau, Paul J.

    1995-01-01

    Geothermal heat pump systems are a promising new energy technology that has shown rapid increase in usage over the past ten years in the United States. These systems offer substantial benefits to customers and utilities in energy (kWh) and demand (kW) savings. The purpose of this study was to determine what existing monitored data was available mainly from electric utilities on heat pump performance, energy savings and demand reduction for residential, school, and commercial building applications. Information was developed on the status of electric utility marketing programs, barriers to market penetration, incentive programs, and benefits.

  1. Molecular heat pump.

    Science.gov (United States)

    Segal, Dvira; Nitzan, Abraham

    2006-02-01

    We propose a molecular device that pumps heat against a thermal gradient. The system consists of a molecular element connecting two thermal reservoirs that are characterized by different spectral properties. The pumping action is achieved by applying an external force that periodically modulates molecular levels. This modulation affects periodic oscillations of the internal temperature of the molecule and the strength of its coupling to each reservoir resulting in a net heat flow in the desired direction. The heat flow is examined in the slow and fast modulation limits and for different modulation wave forms, thus making it possible to optimize the device performance.

  2. Insulin pump therapy in children with type 1 diabetes

    DEFF Research Database (Denmark)

    Szypowska, Agnieszka; Schwandt, Anke; Svensson, Jannet

    2016-01-01

    BACKGROUND: Intensified insulin delivery using multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII) is recommended in children with type 1 diabetes (T1D) to achieve good metabolic control. OBJECTIVE: To examine the frequency of pump usage in T1D children treated...... in SWEET (Better control in Paediatric and Adolescent diabeteS: Working to crEate CEnTers of Reference) centers and to compare metabolic control between patients treated with CSII vs MDI. METHODS: This study included 16 570 T1D children participating in the SWEET prospective, multicenter, standardized...... diabetes patient registry. Datasets were aggregated over the most recent year of treatment for each patient. Data were collected until March 2016. To assess the organization of pump therapy a survey was carried out. RESULTS: Overall, 44.4% of T1D children were treated with CSII. The proportion of patients...

  3. The Effect of Viscosity on Performance of a Low Specific Speed Centrifugal Pump

    Directory of Open Access Journals (Sweden)

    Rouhollah Torabi

    2016-01-01

    Full Text Available Centrifugal pump delivery head and flow rate drop effectively during the pumping of viscous fluids. Several methods and correlations have been developed to predict reduction rate in centrifugal pump performance when handling viscous fluids, but their results are not in very good agreement with each other. In this study, a common industrial low specific speed pump, which is extensively used in different applications, is studied. The entire pump, including impeller, volute, pipes, front and rear sidewall gaps, and balance holes, is simulated in Computational Fluid Dynamics and 3D full Navier Stokes equations are solved. CFD results are compared with experimental data such as pump performance curves, static pressure in casing, and disk friction loss. Dimensionless angular velocity and leakage rate are investigated in sidewall gap and efficiency variation due to viscosity is studied. The results demonstrate that the behavior of the fluid in sidewall gap is strictly sensitive to viscosity. Increasing viscosity improves the volumetric efficiency by reducing internal leakage through wear rings and balance holes, causing, however, a significant fall in the disk and overall efficiency. Results lead to some recommendations for designing centrifugal pumps which may be used in transferring viscous fluids.

  4. Perineural infusion of 0.5% ropivacaine for successful treatment of phantom limb syndrome: a case report.

    Science.gov (United States)

    Borghi, B; Bugamelli, S; Stagni, G; Missiroli, M; Genco, R; Colizza, M T

    2009-11-01

    Phantom limb syndrome (PLS) comprises various disturbances, including pain in the missing limb and phantom sensations. This study is about the successful treatment of a PLS patient by prolonged infusion of local anesthetic through a perineural catheter. A 45-year-old man came to the Rizzoli Orthopedic Institute (Bologna, Italy) complaining of a painful right leg after trauma. Complex regional pain syndrome (CRPS) type II was diagnosed. Therapy with tricyclics, gabapentin, and spinal infusion of morphine was started. After 4 years of treatment, infection led to the need for right below-the-knee amputation. After amputation, PLS appeared immediately and was not responsive to pharmacological treatment. At day II, a perineural sciatic catheter was positioned and 0.5% ropivacaine infusion with an elastomeric pump at 5 mL/h was started. The infusion was temporarily discontinued every week to evaluate the PLS. After 7 days, a 30% reduction in pain was observed, increased to 60% after 14 days, and disappeared completely after 21 days, leaving only the phantom limb sensations. After 28 days of continuous infusion, the phantom limb sensations had also disappeared. The perineural catheter was removed after 48 hours without perineural infusion. The patient was weaned from morphine over 150 days. Follow-ups at 6, 12, 24, and 36 months confirmed that the PLS did not reappear. The results are limited to one patient but are encouraging, particularly due to the relevance of the pathology and the poor results of conventional treatments. More cases are obviously needed to support the efficacy of this therapy.

  5. Evaluation of Talbot's Safety Zone of Infusion Volume and Osmolality in Infusion Therapy for Decompensated Liver Cirrhosis

    Directory of Open Access Journals (Sweden)

    Yuasa,Shiro

    1985-06-01

    Full Text Available Problems with infusion therapy for correcting fluid and sodium imbalance in decompensated liver cirrhosis (DLC were investigated by establishing the safety zone of Talbot et al. for parenteral fluid therapy in 4 DLC patients infused with over 900 ml of fluid each day for at least 9 days. The safety zone was different in each case. The safe infusion volume decreased and the safe electrolyte concentration shifted to a lower osmolality when there was ascites with renal failure than ascites without renal failure. Infusion therapy was performed without deterioration of the water and sodium balance in those patients whose infusion volume and fluid osmolality were in the safety zone. In contrast, ascites retention increased and peripheral edema appeared in patients whose infusion volume and osmolality were out of the safety zone. Therefore, the safety zone should be determined repeatedly during infusion therapy.

  6. Pressurized Vessel Slurry Pumping

    Energy Technology Data Exchange (ETDEWEB)

    Pound, C.R.

    2001-09-17

    This report summarizes testing of an alternate ''pressurized vessel slurry pumping'' apparatus. The principle is similar to rural domestic water systems and ''acid eggs'' used in chemical laboratories in that material is extruded by displacement with compressed air.

  7. Microfluidic "blinking" bubble pump

    NARCIS (Netherlands)

    Yin, Zhizhong; Prosperetti, Andrea

    2005-01-01

    The paper reports data obtained on a simple micropump, suitable for electrolytes, based on the periodic growth and collapse of a single vapor bubble in a microchannel. With a channel diameter of the order of 100 µm, pumping rates of several tens of µl/min and pressure differences of several kPa are

  8. Cold Climate Heat Pump

    Science.gov (United States)

    2013-08-01

    12. Data set 7 – energy consumption of heat pump and furnace ................................ 22 Figure 13. Experimentally adjusted TRNSYS model...minute SCF standard cubic feet SEER seasonal energy efficiency ratio SH superheated TMY Typical Meteorological Year TRNSYS Transient Systems...Simulation Program ( TRNSYS ), to generate an experimentally adjusted, simulation heating seasonal performance. 6.4.1 Simulation Results The TRNSYS model

  9. The Osmotic Pump

    Science.gov (United States)

    Levenspiel, Octave; de Nevers, Noel

    1974-01-01

    Describes the principle involved in an osmotic pump used to extract fresh water from the oceans and in an osmotic power plant used to generate electricity. Although shown to be thermodynamically feasible, the osmotic principle is not likely to be used commerically for these purposes in the near future. (JR)

  10. Insulin pumps in pregnancy: using technology to achieve normoglycemia in women with diabetes.

    Science.gov (United States)

    Castorino, Kristin; Paband, Rashid; Zisser, Howard; Jovanovič, Lois

    2012-02-01

    Poorly controlled diabetes before conception and during pregnancy among women with pre-existing diabetes can cause major birth defects and spontaneous abortions, as wells as abnormal fetal growth and development including an offspring who is small or large for gestational age, or predisposed to obesity, type 2 diabetes, and metabolic syndrome in his/her lifetime. Conversely, for a woman with pre-existing diabetes, optimizing blood glucose levels before and during early pregnancy can reduce these risks dramatically. As insulin pump technology has evolved, continuous subcutaneous insulin infusion has become a safe and reliable method for treating diabetes during pregnancy. Although pump therapy is often preferred by patients and some experts, insulin pumps have not yet been shown to be superior to multiple daily injections of insulin during pregnancy. In this review of the literature we focus on the use of insulin pumps in the management of diabetes in pregnancy.

  11. Optimization of compound gear pump

    Institute of Scientific and Technical Information of China (English)

    栾振辉

    2002-01-01

    This paper introduces the performances of compound gear pump. Based on the target of having the smallest mass per unit volume, the paper established a mathematical model of optimization, and obtained the results of optimization of the pump.

  12. RSES heat pump technician certification

    Energy Technology Data Exchange (ETDEWEB)

    Zeiner, J.

    1996-06-01

    In 1987 the National Heat Pump certification test was developed by the Refrigeration Service Engineers Society (RSES), and in 1994, the program was more specifically named Heat Pump Service Technician Certification. This report describes the benefits of certification.

  13. Orbital Liquid Oxygen Pump Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposed work will develop a pump, which is based on two novel and unique design features. The first feature is a lobed pumping mechanism which operates with...

  14. Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products

    Science.gov (United States)

    Cunningham, Charles H.; Chen, Albert P.; Lustig, Michael; Hargreaves, Brian A.; Lupo, Janine; Xu, Duan; Kurhanewicz, John; Hurd, Ralph E.; Pauly, John M.; Nelson, Sarah J.; Vigneron, Daniel B.

    2008-07-01

    Dynamic nuclear polarization and dissolution of a 13C-labeled substrate enables the dynamic imaging of cellular metabolism. Spectroscopic information is typically acquired, making the acquisition of dynamic volumetric data a challenge. To enable rapid volumetric imaging, a spectral-spatial excitation pulse was designed to excite a single line of the carbon spectrum. With only a single resonance present in the signal, an echo-planar readout trajectory could be used to resolve spatial information, giving full volume coverage of 32 × 32 × 16 voxels every 3.5 s. This high frame rate was used to measure the different lactate dynamics in different tissues in a normal rat model and a mouse model of prostate cancer.

  15. Nonrigid registration of volumetric images using ranked order statistics

    DEFF Research Database (Denmark)

    Tennakoon, Ruwan; Bab-Hadiashar, Alireza; Cao, Zhenwei

    2014-01-01

    Non-rigid image registration techniques using intensity based similarity measures are widely used in medical imaging applications. Due to high computational complexities of these techniques, particularly for volumetric images, finding appropriate registration methods to both reduce the computation...... burden and increase the registration accuracy has become an intensive area of research. In this paper we propose a fast and accurate non-rigid registration method for intra-modality volumetric images. Our approach exploits the information provided by an order statistics based segmentation method, to find...... the important regions for registration and use an appropriate sampling scheme to target those areas and reduce the registration computation time. A unique advantage of the proposed method is its ability to identify the point of diminishing returns and stop the registration process. Our experiments...

  16. Volumetric characterization of delamination fields via angle longitudinal wave ultrasound

    Science.gov (United States)

    Wertz, John; Wallentine, Sarah; Welter, John; Dierken, Josiah; Aldrin, John

    2017-02-01

    The volumetric characterization of delaminations necessarily precedes rigorous composite damage progression modeling. Yet, inspection of composite structures for subsurface damage remains largely focused on detection, resulting in a capability gap. In response to this need, angle longitudinal wave ultrasound was employed to characterize a composite surrogate containing a simulated three-dimensional delamination field with distinct regions of occluded features (shadow regions). Simple analytical models of the specimen were developed to guide subsequent experimentation through identification of optimal scanning parameters. The ensuing experiments provided visual evidence of the complete delamination field, including indications of features within the shadow regions. The results of this study demonstrate proof-of-principle for the use of angle longitudinal wave ultrasonic inspection for volumetric characterization of three-dimensional delamination fields. Furthermore, the techniques developed herein form the foundation of succeeding efforts to characterize impact delaminations within inhomogeneous laminar materials such as polymer matrix composites.

  17. Magnetic Resonance Image Segmentation and its Volumetric Measurement

    Directory of Open Access Journals (Sweden)

    Rahul R. Ambalkar

    2013-02-01

    Full Text Available Image processing techniques make it possible to extract meaningful information from medical images. Magnetic resonance (MR imaging has been widely applied in biological research and diagnostics because of its excellent soft tissue contrast, non-invasive character, high spatial resolution and easy slice selection at any orientation. The MRI-based brain volumetric is concerned with the analysis of volumes and shapes of the structural components of the human brain. It also provides a criterion, by which we recognize the presence of degenerative diseases and characterize their rates of progression to make the diagnosis and treatments as a easy task. In this paper we have proposed an automated method for volumetric measurement of Magnetic Resonance Imaging and used Self Organized Map (SOM clustering method for their segmentations. We have used the MRI data set of 61 slices of 256×256 pixels in DICOM standard format

  18. Two-dimensional random arrays for real time volumetric imaging

    DEFF Research Database (Denmark)

    Davidsen, Richard E.; Jensen, Jørgen Arendt; Smith, Stephen W.

    1994-01-01

    Two-dimensional arrays are necessary for a variety of ultrasonic imaging techniques, including elevation focusing, 2-D phase aberration correction, and real time volumetric imaging. In order to reduce system cost and complexity, sparse 2-D arrays have been considered with element geometries...... real time volumetric imaging system, which employs a wide transmit beam and receive mode parallel processing to increase image frame rate. Depth-of-field comparisons were made from simulated on-axis and off-axis beamplots at ranges from 30 to 160 mm for both coaxial and offset transmit and receive...... selected ad hoc, by algorithm, or by random process. Two random sparse array geometries and a sparse array with a Mills cross receive pattern were simulated and compared to a fully sampled aperture with the same overall dimensions. The sparse arrays were designed to the constraints of the Duke University...

  19. In Vivo Real Time Volumetric Synthetic Aperture Ultrasound Imaging

    DEFF Research Database (Denmark)

    Bouzari, Hamed; Rasmussen, Morten Fischer; Brandt, Andreas Hjelm

    2015-01-01

    . This paper investigates the in vivo applicability and sensitivity of volumetric SA imaging. Utilizing the transmit events to generate a set of virtual point sources, a frame rate of 25 Hz for a 90° x 90° field-of-view was achieved. Data were obtained using a 3.5 MHz 32 x 32 elements 2-D phased array......Synthetic aperture (SA) imaging can be used to achieve real-time volumetric ultrasound imaging using 2-D array transducers. The sensitivity of SA imaging is improved by maximizing the acoustic output, but one must consider the limitations of an ultrasound system, both technical and biological...... transducer connected to the experimental scanner (SARUS). Proper scaling is applied to the excitation signal such that intensity levels are in compliance with the U.S. Food and Drug Administration regulations for in vivo ultrasound imaging. The measured Mechanical Index and spatial-peak- temporal...

  20. COMPARISON OF VOLUMETRIC REGISTRATION ALGORITHMS FOR TENSOR-BASED MORPHOMETRY

    Science.gov (United States)

    Villalon, Julio; Joshi, Anand A.; Toga, Arthur W.; Thompson, Paul M.

    2015-01-01

    Nonlinear registration of brain MRI scans is often used to quantify morphological differences associated with disease or genetic factors. Recently, surface-guided fully 3D volumetric registrations have been developed that combine intensity-guided volume registrations with cortical surface constraints. In this paper, we compare one such algorithm to two popular high-dimensional volumetric registration methods: large-deformation viscous fluid registration, formulated in a Riemannian framework, and the diffeomorphic “Demons” algorithm. We performed an objective morphometric comparison, by using a large MRI dataset from 340 young adult twin subjects to examine 3D patterns of correlations in anatomical volumes. Surface-constrained volume registration gave greater effect sizes for detecting morphometric associations near the cortex, while the other two approaches gave greater effects sizes subcortically. These findings suggest novel ways to combine the advantages of multiple methods in the future. PMID:26925198

  1. Endothelial Cell Toxicity of Vancomycin Infusion Combined with Other Antibiotics.

    Science.gov (United States)

    Drouet, Maryline; Chai, Feng; Barthélémy, Christine; Lebuffe, Gilles; Debaene, Bertrand; Décaudin, Bertrand; Odou, Pascal

    2015-08-01

    French guidelines recommend central intravenous (i.v.) infusion for high concentrations of vancomycin, but peripheral intravenous (p.i.v.) infusion is often preferred in intensive care units. Vancomycin infusion has been implicated in cases of phlebitis, with endothelial toxicity depending on the drug concentration and the duration of the infusion. Vancomycin is frequently infused in combination with other i.v. antibiotics through the same administrative Y site, but the local toxicity of such combinations has been poorly evaluated. Such an assessment could improve vancomycin infusion procedures in hospitals. Human umbilical vein endothelial cells (HUVEC) were challenged with clinical doses of vancomycin over 24 h with or without other i.v. antibiotics. Cell death was measured with the alamarBlue test. We observed an excess cellular death rate without any synergistic effect but dependent on the numbers of combined infusions when vancomycin and erythromycin or gentamicin were infused through the same Y site. Incompatibility between vancomycin and piperacillin-tazobactam was not observed in our study, and rinsing the cells between the two antibiotic infusions did not reduce endothelial toxicity. No endothelial toxicity of imipenem-cilastatin was observed when combined with vancomycin. p.i.v. vancomycin infusion in combination with other medications requires new recommendations to prevent phlebitis, including limiting coinfusion on the same line, reducing the infusion rate, and choosing an intermittent infusion method. Further studies need to be carried out to explore other drug combinations in long-term vancomycin p.i.v. therapy so as to gain insight into the mechanisms of drug incompatibility under multidrug infusion conditions.

  2. Volumetric 3D display using a DLP projection engine

    Science.gov (United States)

    Geng, Jason

    2012-03-01

    In this article, we describe a volumetric 3D display system based on the high speed DLPTM (Digital Light Processing) projection engine. Existing two-dimensional (2D) flat screen displays often lead to ambiguity and confusion in high-dimensional data/graphics presentation due to lack of true depth cues. Even with the help of powerful 3D rendering software, three-dimensional (3D) objects displayed on a 2D flat screen may still fail to provide spatial relationship or depth information correctly and effectively. Essentially, 2D displays have to rely upon capability of human brain to piece together a 3D representation from 2D images. Despite the impressive mental capability of human visual system, its visual perception is not reliable if certain depth cues are missing. In contrast, volumetric 3D display technologies to be discussed in this article are capable of displaying 3D volumetric images in true 3D space. Each "voxel" on a 3D image (analogous to a pixel in 2D image) locates physically at the spatial position where it is supposed to be, and emits light from that position toward omni-directions to form a real 3D image in 3D space. Such a volumetric 3D display provides both physiological depth cues and psychological depth cues to human visual system to truthfully perceive 3D objects. It yields a realistic spatial representation of 3D objects and simplifies our understanding to the complexity of 3D objects and spatial relationship among them.

  3. VIRTUAL FUEL-PUMP DESIGN

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Some concepts of virtual product are discussed. The key technologies of virtual fuel-pump development are in detail analysed, which include virtual fuel-pump product modeling, intelligent simulation, distributed design environment, and virtual assembly. The virtual fuel-pump development prototype system considers requirement analysis, concept design, injection preferment analysis, detailed design, and assembly analysis.

  4. Small Scroll Pump for Cryogenic Liquids Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The innovation is a compact, reliable, light weight, electrically driven pump capable of pumping cryogenic liquids, based on scroll pump technology. This pump will...

  5. Improving pumping system efficiency at coal plants

    Energy Technology Data Exchange (ETDEWEB)

    Livoti, W.C.; McCandless, S.; Poltorak, R. [Baldor Electric Co. (United States)

    2009-03-15

    The industry must employ ultramodern technologies when building or upgrading power plant pumping systems thereby using fuels more efficiently. The article discusses the uses and efficiencies of positive displacement pumps, centrifugal pumps and multiple screw pumps. 1 ref., 4 figs.

  6. Using surface heave to estimate reservoir volumetric strain

    Energy Technology Data Exchange (ETDEWEB)

    Nanayakkara, A.S.; Wong, R.C.K. [Calgary Univ., AB (Canada)

    2008-07-01

    This paper presented a newly developed numerical tool for estimating reservoir volumetric strain distribution using surface vertical displacements and solving an inverse problem. Waterflooding, steam injection, carbon dioxide sequestration and aquifer storage recovery are among the subsurface injection operations that are responsible for reservoir dilations which propagate to the surrounding formations and extend to the surface resulting in surface heaves. Global positioning systems and surface tiltmeters are often used to measure the characteristics of these surface heaves and to derive valuable information regarding reservoir deformation and flow characteristics. In this study, Tikhonov regularization techniques were adopted to solve the ill-posed inversion problem commonly found in standard inversion techniques such as Gaussian elimination and least squares methods. Reservoir permeability was then estimated by inverting the volumetric strain distribution. Results of the newly developed numerical tool were compared with results from fully-coupled finite element simulation of fluid injection problems. The reservoir volumetric strain distribution was successfully estimated along with an approximate value for reservoir permeability.

  7. Volumetric Light-field Encryption at the Microscopic Scale

    Science.gov (United States)

    Li, Haoyu; Guo, Changliang; Muniraj, Inbarasan; Schroeder, Bryce C.; Sheridan, John T.; Jia, Shu

    2017-01-01

    We report a light-field based method that allows the optical encryption of three-dimensional (3D) volumetric information at the microscopic scale in a single 2D light-field image. The system consists of a microlens array and an array of random phase/amplitude masks. The method utilizes a wave optics model to account for the dominant diffraction effect at this new scale, and the system point-spread function (PSF) serves as the key for encryption and decryption. We successfully developed and demonstrated a deconvolution algorithm to retrieve both spatially multiplexed discrete data and continuous volumetric data from 2D light-field images. Showing that the method is practical for data transmission and storage, we obtained a faithful reconstruction of the 3D volumetric information from a digital copy of the encrypted light-field image. The method represents a new level of optical encryption, paving the way for broad industrial and biomedical applications in processing and securing 3D data at the microscopic scale.

  8. Volumetric Light-field Encryption at the Microscopic Scale

    Science.gov (United States)

    Li, Haoyu; Guo, Changliang; Muniraj, Inbarasan; Schroeder, Bryce C.; Sheridan, John T.; Jia, Shu

    2017-01-01

    We report a light-field based method that allows the optical encryption of three-dimensional (3D) volumetric information at the microscopic scale in a single 2D light-field image. The system consists of a microlens array and an array of random phase/amplitude masks. The method utilizes a wave optics model to account for the dominant diffraction effect at this new scale, and the system point-spread function (PSF) serves as the key for encryption and decryption. We successfully developed and demonstrated a deconvolution algorithm to retrieve both spatially multiplexed discrete data and continuous volumetric data from 2D light-field images. Showing that the method is practical for data transmission and storage, we obtained a faithful reconstruction of the 3D volumetric information from a digital copy of the encrypted light-field image. The method represents a new level of optical encryption, paving the way for broad industrial and biomedical applications in processing and securing 3D data at the microscopic scale. PMID:28059149

  9. Volumetric Light-field Encryption at the Microscopic Scale

    CERN Document Server

    Li, Haoyu; Muniraj, Inbarasan; Schroeder, Bryce C; Sheridan, John T; Jia, Shu

    2016-01-01

    We report a light-field based method that allows the optical encryption of three-dimensional (3D) volumetric information at the microscopic scale in a single 2D light-field image. The system consists of a microlens array and an array of random phase/amplitude masks. The method utilizes a wave optics model to account for the dominant diffraction effect at this new scale, and the system point-spread function (PSF) serves as the key for encryption and decryption. We successfully developed and demonstrated a deconvolution algorithm to retrieve spatially multiplexed discrete and continuous volumetric data from 2D light-field images. Showing that the method is practical for data transmission and storage, we obtained a faithful reconstruction of the 3D volumetric information from a digital copy of the encrypted light-field image. The method represents a new level of optical encryption, paving the way for broad industrial and biomedical applications in processing and securing 3D data at the microscopic scale.

  10. Volumetric Light-field Encryption at the Microscopic Scale.

    Science.gov (United States)

    Li, Haoyu; Guo, Changliang; Muniraj, Inbarasan; Schroeder, Bryce C; Sheridan, John T; Jia, Shu

    2017-01-06

    We report a light-field based method that allows the optical encryption of three-dimensional (3D) volumetric information at the microscopic scale in a single 2D light-field image. The system consists of a microlens array and an array of random phase/amplitude masks. The method utilizes a wave optics model to account for the dominant diffraction effect at this new scale, and the system point-spread function (PSF) serves as the key for encryption and decryption. We successfully developed and demonstrated a deconvolution algorithm to retrieve both spatially multiplexed discrete data and continuous volumetric data from 2D light-field images. Showing that the method is practical for data transmission and storage, we obtained a faithful reconstruction of the 3D volumetric information from a digital copy of the encrypted light-field image. The method represents a new level of optical encryption, paving the way for broad industrial and biomedical applications in processing and securing 3D data at the microscopic scale.

  11. [Guidelines concerning insulin dosage in children and adolescents with type 1 diabetes on continuous subcutaneous insulin infusion].

    Science.gov (United States)

    Szypowska, Agnieszka; Pańkowska, Ewa; Lipka, Maria

    2006-01-01

    The treatment of diabetes mellitus with a continuous subcutaneous insulin infusion (CSII) has become very popular and is well accepted by diabetic patients. Pump therapy mimics the physiological insulin secretion and has been shown to be a safe and effective method of insulin administration alternative to the method of multiple injections. Continuous insulin infusion provides greater flexibility in the timing of meals and snacks with higher treatment satisfaction. Programmed basal rates improve nocturnal glycemic control and help to minimize a pre-breakfast increase of blood glucose level (the dawn phenomenon). Moreover, CSII can reduce exercise-induced and nocturnal hypoglycemia. Insulin pump therapy is effective in lowering glycated hemoglobin levels without higher risk of severe hypoglycaemia and ketoacidosis. To achieve a proper metabolic control with this method of treatment, the patient and his family requires appropriate education including knowledge of diet management, insulin therapy and manual competence of pump device. Here we present general guidelines for patients education concerning insulin dosage, programming of basal insulin rates and meal boluses based on carbohydrates and protein-fat exchanges.

  12. Pumping characteristics of roots blower pumps for light element gases

    Energy Technology Data Exchange (ETDEWEB)

    Hiroki, Seiji; Abe, Tetsuya; Tanzawa, Sadamitsu; Nakamura, Jun-ichi; Ohbayashi, Tetsuro [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment

    2002-07-01

    The pumping speed and compression ratio of the two-stage roots blower pumping system were measured for light element gases (H{sub 2}, D{sub 2} and He) and for N{sub 2}, in order to assess validity of the ITER torus roughing system as an ITER R and D task (T234). The pumping system of an Edwards EH1200 (nominal pumping speed of 1200 m{sup 3}/s), two EH250s (ibid. 250 m{sup 3}/s) and a backing pump (ibid. 100 m{sup 3}/s) in series connection was tested under PNEUROP standards. The maximum pumping speeds of the two-stage system for D{sub 2} and N{sub 2} were 1200 and 1300 m{sup 3}/h, respectively at 60 Hz, which satisfied the nominal pumping speed. These experimental data support the design validity of the ITER torus roughing system. (author)

  13. Continuous infusion versus daily injections of growth hormone (GH) for 4 weeks in GH-deficient patients

    DEFF Research Database (Denmark)

    Laursen, Torben; Jørgensen, Jens Otto Lunde; Jakobsen, Grethe

    1995-01-01

    infusion by means of a portable pump for 1 month and as daily sc injections (at 1900 h) for another month. An average daily GH dosage (+/- SEM) of 3.15 +/- 0.27 IU was administered during both periods. Steady state 24-h profiles of GH, IGF-I, IGF-binding proteins (IGFBPs), insulin, glucose, lipid......Abstract Endogenous GH secretion is pulsatile. Animal studies indicate that GH administered in a pulsatile manner induces growth and insulin-like growth factor I (IGF-I) generation more effectively than continuous administration. Short term human studies, however, have reported similar metabolic.......5 +/- 50.2 (injection) and 334.6 +/- 46.6 (infusion)]. Similarly, constant GH delivery induced higher IGFBP-3 levels (P insulin levels (P

  14. Software Infusion: Using Computers to Enhance Instruction. Part One: What Does Software Infusion Look Like?

    Science.gov (United States)

    Schiffman, Shirl S.

    1986-01-01

    This first of two articles presents eight examples of what software infusion (SI) looks like in actual practice in elementary, middle, and high school classrooms and learning laboratories. An analysis of SI characteristics demonstrated in the examples is presented to bring the definition of SI into focus. (MBR)

  15. Continuous infusion of enzyme replacement therapy is inferior to weekly infusions in MPS I dogs.

    Science.gov (United States)

    Passage, M B; Krieger, A W; Peinovich, M C; Lester, T; Le, S Q; Dickson, P I; Kakkis, E D

    2009-12-01

    Intravenous enzyme replacement therapy with recombinant human α-L-iduronidase (rhIDU) is used weekly to treat mucopolysaccharidosis (MPS) I. We tested continuous administration of rhIDU at two dosing levels (0.58 mg/kg per week and 2 mg/kg per week) in MPS I dogs, and compared the efficacy of continuous infusion with the clinically used 0.58 mg/kg weekly three-hour infusion. Peak plasma concentrations of rhIDU were much higher in weekly-treated dogs (mean 256 units/ml) than steady-state concentrations in dogs treated with continuous infusion (mean 1.97 units/ml at 0.58 mg/kg per week; 8.44 units/ml at 2 mg/kg per week). Dogs receiving continuous IV rhIDU, even at a higher (2 mg/kg per week) dose, had consistently lower iduronidase levels in tissues than dogs receiving a weekly (0.58 mg/kg per week) dose. GAG storage was also less improved by continuous intravenous infusion. Adverse events were similar in all dosing groups. We found that continuous administration of 2 mg/kg per week rhIDU to MPS I dogs was insufficient to achieve GAG storage reduction comparable to 0.58 mg/kg weekly dosing.

  16. SHINE Vacuum Pump Test Verification

    Energy Technology Data Exchange (ETDEWEB)

    Morgan, Gregg A; Peters, Brent

    2013-09-30

    Normetex pumps used world-wide for tritium service are no longer available. DOE and other researchers worldwide have spent significant funds characterizing this pump. Identification of alternate pumps is required for performance and compatibility with tritium gas. Many of the pumps that could be used to meet the functional performance requirements (e.g. pressure and flow conditions) of the Normetex pump have features that include the use of polymers or oils and greases that are not directly compatible with tritium service. This study assembles a test system to determine the flow characteristics for candidate alternate pumps. These tests are critical to the movement of tritium through the SHINE Tritium Purification System (TPS). The purpose of the pump testing is two-fold: (1) obtain baseline vacuum pump characteristics for an alternate (i.e. ''Normetex replacement'') pump intended for use in tritium service; and (2) verify that low pressure hydrogen gas can be transported over distances up to 300 feet by the candidate pumps. Flow rates and nominal system pressures have been identified for the SHINE Mo-99 production process Tritium Purification System (TPS). To minimize the line sizes for the transfer of low pressure tritium from the Neutron Driver Accelerator System (NDAS) to the primary processing systems in the TPS, a ''booster'' pump has been located near the accelerator in the design. A series of pump tests were performed at various configurations using hydrogen gas (no tritium) to ensure that this concept is practical and maintains adequate flow rates and required pressures. This report summarizes the results of the tests that have been performed using various pump configurations. The current design of the Tritium Purification System requires the ''booster'' pump to discharge to or to be backed by another vacuum pump. Since Normetex pumps are no longer manufactured, a commercially available Edwards

  17. 14 CFR 23.991 - Fuel pumps.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fuel pumps. 23.991 Section 23.991... § 23.991 Fuel pumps. (a) Main pumps. For main pumps, the following apply: (1) For reciprocating engine installations having fuel pumps to supply fuel to the engine, at least one pump for each engine must be...

  18. The U.K. service level audit of insulin pump therapy in adults.

    Science.gov (United States)

    White, H D; Goenka, N; Furlong, N J; Saunders, S; Morrison, G; Langridge, P; Paul, P; Ghatak, A; Weston, P J

    2014-04-01

    The National Institute for Health and Clinical Excellence (NICE) published guidelines for the use of continuous subcutaneous insulin infusion in 2008 (technology appraisal 151). The first U.K.-wide insulin pump audit took place in 2012 with the aim of determining adherence to the guidance issued in NICE technology appraisal 151. The results of the adult service level audit are reported here. All centres providing continuous subcutaneous insulin infusion services to adults with diabetes in the U.K. were invited to participate. Audit metrics were aligned to technology appraisal 151. Data entry took place online using a DiabetesE formatted data collection tool. One hundred and eighty-three centres were identified as delivering adult continuous subcutaneous insulin infusion services in the U.K., of which 178 (97.3%) participated in the audit. At the time of the audit, 13 428 adults were using insulin pump therapy, giving an estimated prevalence of use of 6%. Ninety-three per cent of centres did not report any barriers in obtaining funding for patients who fulfilled NICE criteria. The mean number of consultant programmed activities dedicated to continuous subcutaneous insulin infusion services was 0.96 (range 0-8), mean whole-time equivalent diabetes specialist nurses was 0.62 (range 0-3) and mean whole-time equivalent dietitian services was 0.3 (range 0-2), of which 39, 61 and 60%, respectively, were not formally funded. The prevalence of continuous subcutaneous insulin infusion use in the U.K. falls well below the expectation of NICE (15-20%) and that of other European countries (> 15%) and the U.S.A. (40%). This may be attributable, in part, to lack of healthcare professional time needed for identification and training of new pump therapy users. © 2013 The Authors. Diabetic Medicine © 2013 Diabetes UK.

  19. Liquid Infused Surfaces in Turbulent Channel Flow

    Science.gov (United States)

    Fu, Matthew; Liu, Ying; Stone, Howard; Hultmark, Marcus

    2016-11-01

    Liquid infused surfaces have been proposed as a robust method for turbulent drag reduction. These surfaces consist of functionalized roughness elements wetted with a liquid lubricant that is immiscible with external fluids. The presence of the lubricant creates mobile, fluid-fluid interfaces, each of which can support a localized slip. Collectively, these interfaces yield a finite slip velocity at the effective surface, which has been demonstrated to reduce skin friction drag in turbulent flows. Retention of the lubricant layer is critical to maintaining the drag reduction effect. A turbulent channel-flow facility is used to characterize the drag reduction and robustness of various liquid infused surfaces. Micro-manufactured surfaces are mounted flush in the channel and exposed to turbulent flows. The retention of fluorescent lubricants and pressure drop are monitored to characterize the effects of surface geometry and lubricant properties. Supported under ONR Grants N00014-12-1-0875 and N00014-12-1-0962 (program manager Ki-Han Kim) and by the Department of Defense (DoD) through the National Defense Science & Engineering Graduate Fellowship (NDSEG) Program.

  20. Drag reduction using slippery liquid infused surfaces

    Science.gov (United States)

    Hultmark, Marcus; Stone, Howard; Smits, Alexander; Jacobi, Ian; Samaha, Mohamed; Wexler, Jason; Shang, Jessica; Rosenberg, Brian; Hellström, Leo; Fan, Yuyang

    2013-11-01

    A new method for passive drag reduction is introduced. A surface treatment inspired by the Nepenthes pitcher plant, previously developed by Wong et al. (2011), is utilized and its design parameters are studied for increased drag reduction and durability. Nano- and micro-structured surfaces infused with a lubricant allow for mobility within the lubricant itself when the surface is exposed to flow. The mobility causes slip at the fluid-fluid interface, which drastically reduces the viscous friction. These new surfaces are fundamentally different from the more conventional superhydrophobic surfaces previously used in drag reduction studies, which rely on a gas-liquid interface. The main advantage of the liquid infused surfaces over the conventional surfaces is that the lubricant adheres more strongly to the surface, decreasing the risk of failure when exposed to turbulence and other high-shear flows. We have shown that these surfaces can reduce viscous drag up to 20% in both Taylor-Couette flow and in a parallel plate rheometer. Supported under ONR Grants N00014-12-1-0875 and N00014-12-1-0962 (program manager Ki-Han Kim).

  1. Pocket pumped image analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kotov, I.V., E-mail: kotov@bnl.gov [Brookhaven National Laboratory, Upton, NY 11973 (United States); O' Connor, P. [Brookhaven National Laboratory, Upton, NY 11973 (United States); Murray, N. [Centre for Electronic Imaging, Open University, Milton Keynes, MK7 6AA (United Kingdom)

    2015-07-01

    The pocket pumping technique is used to detect small electron trap sites. These traps, if present, degrade CCD charge transfer efficiency. To reveal traps in the active area, a CCD is illuminated with a flat field and, before image is read out, accumulated charges are moved back and forth number of times in parallel direction. As charges are moved over a trap, an electron is removed from the original pocket and re-emitted in the following pocket. As process repeats one pocket gets depleted and the neighboring pocket gets excess of charges. As a result a “dipole” signal appears on the otherwise flat background level. The amplitude of the dipole signal depends on the trap pumping efficiency. This paper is focused on trap identification technique and particularly on new methods developed for this purpose. The sensor with bad segments was deliberately chosen for algorithms development and to demonstrate sensitivity and power of new methods in uncovering sensor defects.

  2. Wavy tube heat pumping

    Energy Technology Data Exchange (ETDEWEB)

    Haldeman, C. W.

    1985-12-03

    A PVC conduit about 4'' in diameter and a little more than 40 feet long is adapted for being seated in a hole in the earth and surrounds a coaxial copper tube along its length that carries Freon between a heat pump and a distributor at the bottom. A number of wavy conducting tubes located between the central conducting tube and the wall of the conduit interconnect the distributor with a Freon distributor at the top arranged for connection to the heat pump. The wavy conducting tubing is made by passing straight soft copper tubing between a pair of like opposed meshing gears each having four convex points in space quadrature separated by four convex recesses with the radius of curvature of each point slightly less than that of each concave recess.

  3. Advanced heat pump cycle

    Energy Technology Data Exchange (ETDEWEB)

    Groll, E.A.; Radermacher, R.

    1993-07-01

    The desorption and absorption process of a vapor compression heat pump with a solution circuit (VCHSC) proceeds at gliding temperature intervals, which can be adjusted over a wide range. In case that the gliding temperature intervals in the desorber and the absorber overlap, a modification of the VCHSC employing a desorber/absorber heat exchange (DAHX) can be introduced, which results in an extreme reduction of the pressure ratio. Although the DAHX-cycle has features of a two-stage cycle, it still requires only one solution pump, one separator and one compressor. Such a cycle for the working pair ammonia/water is built in the Energy Laboratory of the Center for Environmental Energy Engineering at the University of Maryland. The experimental results obtained with the research plant are discussed and compared to those calculated with a simulation program. The possible temperature lift between heat source and heat sink depending on the achievable COP are presented.

  4. Inertial microfluidic pump

    Science.gov (United States)

    Kornilovitch, Pavel; Govyadinov, Alexander; Markel, David; Torniainen, Erik

    2015-11-01

    The inertial pump is powered by a microheater positioned near one end of a fluidic microchannel. As the microheater explosively boils the surrounding fluid, a vapor bubble expands and then collapses asymmetrically, resulting in net flow. Such devices become an effective means of transporting fluids at microscale. They have no moving parts and can be manufactured in large numbers using standard batch fabrication processes. In this presentation, physical principles behind pump operation are described, in particular the role of reservoirs in dissipating mechanical momentum and the expansion-collapse asymmetry. An effective one-dimensional dynamic model is formulated and solved. The model is compared with full three-dimensional CFD simulations and available experimental data. Potential applications of inertial micropumps are described.

  5. Technology assessment heat pumps

    Energy Technology Data Exchange (ETDEWEB)

    Rudolph, R.; Purper, G. (Battelle-Institut e.V., Frankfurt am Main (Germany, F.R.))

    Technology assessment for an increased application of heat pumps is carried out in four areas: Effects in the economics area, i.e. effects on the economic goals which are defined in the Stability Law, on the goals of the power supply policy which result from the energy programme and its projections, and on the economic structure as a whole. The whole range of social problems concerning the use of heat pumps, i.e. the questions which social groups are affected, how they react, and what consequences are they expected to have on energy conservation as an object of social policy. Consequences in the governmental and administrative sectors, i.e. effects on legislation, administration and government budgets. Effects on the ecological systems; of prime interest in this context are the utilisation of environmental energy, changes in the heat balance, and emmission of pollutants.

  6. A fuzzy logic controller for hormone administration using an implantable pump

    Science.gov (United States)

    Coles, L. Stephen; Wells, George H., Jr.

    1994-01-01

    This paper describes the requirements for a Fuzzy Logic Controller for the physiologic administration of hormones by means of a FDA-approved surgically implantable infusion pump. Results of a LabVIEW computer simulation for the administration of insulin for diabetic adult patients as well as human growth hormone for pediatric patients are presented. A VHS video tape of the simulation in action has been prepared and is available for viewing.

  7. Hydrodynamics of Pumps

    OpenAIRE

    Brennen, Christopher Earls

    1994-01-01

    The subject of this monograph is the fluid dynamics of liquid turbomachines, particularly pumps. Rather than attempt a general treatise on turbomachines, we shall focus attention on those special problems and design issues associated with the flow of liquid through a rotating machine. There are two characteristics of a liquid that lead to these special problems, and cause a significantly different set of concerns than would occur in, say, a gas turbine. These are the potential for cavitation ...

  8. Pioneering Heat Pump Project

    Energy Technology Data Exchange (ETDEWEB)

    Aschliman, Dave [Indiana Inst. of Technology, Inc., Fort Wayne, IN (United States); Lubbehusen, Mike [Indiana Inst. of Technology, Inc., Fort Wayne, IN (United States)

    2015-06-30

    This project was initiated at a time when ground coupled heat pump systems in this region were limited in size and quantity. There were economic pressures with costs for natural gas and electric utilities that had many organizations considering ground coupled heat pumps; The research has added to the understanding of how ground temperatures fluctuate seasonally and how this affects the performance and operation of the heat pumps. This was done by using a series of temperature sensors buried within the middle of one of the vertical bore fields with sensors located at various depths below grade. Trending of the data showed that there is a lag in ground temperature with respect to air temperatures in the shoulder months, however as full cooling and heating season arrives, the heat rejection and heat extraction from the ground has a significant effect on the ground temps; Additionally it is better understood that while a large community geothermal bore field serving multiple buildings does provide a convenient central plant to use, it introduces complexity of not being able to easily model and predict how each building will contribute to the loads in real time. Additional controllers and programming were added to provide more insight into this real time load profile and allow for intelligent shedding of load via a dry cooler during cool nights in lieu of rejecting to the ground loop. This serves as a means to ‘condition’ the ground loop and mitigate thermal creep of the field, as is typically observed; and It has been observed when compared to traditional heating and cooling equipment, there is still a cost premium to use ground source heat pumps that is driven mostly by the cost for vertical bore holes. Horizontal loop systems are less costly to install, but do not perform as well in this climate zone for heating mode

  9. Positive displacement rotary pump

    Science.gov (United States)

    Moody, Paul E.

    1994-04-01

    An eccentric drive rotates inside a ring that is hinged to a plate and an elastomeric curtain is wrapped around the ring and across an articulated plate. The curtain moves along a cylindrical wall inside the pump cavity to move fluid from an inlet to an outlet end of the chamber. Two or more chambers can be coupled in series or in parallel with one another.

  10. Nonazeotropic Heat Pump

    Science.gov (United States)

    Ealker, David H.; Deming, Glenn

    1991-01-01

    Heat pump collects heat from water circulating in heat-rejection loop, raises temperature of collected heat, and transfers collected heat to water in separate pipe. Includes sealed motor/compressor with cooling coils, evaporator, and condenser, all mounted in outer housing. Gradients of temperature in evaporator and condenser increase heat-transfer efficiency of vapor-compression cycle. Intended to recover relatively-low-temperature waste heat and use it to make hot water.

  11. Nonazeotropic Heat Pump

    Science.gov (United States)

    Ealker, David H.; Deming, Glenn

    1991-01-01

    Heat pump collects heat from water circulating in heat-rejection loop, raises temperature of collected heat, and transfers collected heat to water in separate pipe. Includes sealed motor/compressor with cooling coils, evaporator, and condenser, all mounted in outer housing. Gradients of temperature in evaporator and condenser increase heat-transfer efficiency of vapor-compression cycle. Intended to recover relatively-low-temperature waste heat and use it to make hot water.

  12. Introduction to Pump Rotordynamics

    Science.gov (United States)

    2006-11-01

    RTO-EN-AVT-143 9 - 1 Introduction to Pump Rotordynamics Luis San Andrés Mast-Childs Tribology Professor Turbomachinery Laboratory Texas A... rotordynamics of turbomachinery, excessive vibration and instability. The acceptable performance of a turbomachine depends on the adequate design and operation...on rotordynamics . The basic equations for the modeling of linear rotor-bearing systems are given along with an example for the rotordynamics of a

  13. Bioactive compounds and antioxidant activity of wolfberry infusion

    Science.gov (United States)

    Sun, Yujing; Rukeya, Japaer; Tao, Wenyang; Sun, Peilong; Ye, Xingqian

    2017-01-01

    An infusion of the wolfberry (Lycium barbarum L.) is a traditional Asian herbal tea. This is the most commonly consumed form of dried wolfberry worldwide, yet little scientific information on wolfberry infusions is available. We investigated the effects of making infusions with hot water on the color, the content of bioactive compounds (polysaccharides, polyphenols, flavonoids and carotenoids) and the antioxidant ability of wolfberry infusions. The contents of bioactive compounds and the antioxidant activity of a wolfberry infusion increased with increased infusion temperature and time. Total polysaccharides content (TPOC), total polyphenols (TPC), total flavonoids (TFC) and total carotenoids contents (TCC) were important for determining the antioxidant capacity of wolfberry infusions with the contribution to antioxidant activity in the order TPC > TFC > TCC > TPOC. Hierarchical cluster analysis indicated preparation conditions of 100 °C for 1~3 h, 90 °C for 2~3 h and 80 °C for 2.5~3 h were equivalent as regards the value of TPC, TPOC, TFC, TCC, FRAP, DPPH and ABTS. The results of this study suggest the length of time of making a wolfberry infusion in actual real life practice is too short and different dietary habits associated with the intake of wolfberry infusion might provide the same bioactive nutrients. PMID:28102295

  14. Rapid Infusion Rituximab for Maintenance Therapy: Is It Feasible?

    Directory of Open Access Journals (Sweden)

    Jolly Patel

    2013-01-01

    Full Text Available Rituximab is an anti-CD-20 monoclonal antibody used in the management of lymphoproliferative disorders. The use of maintenance rituximab has improved progression free survival and overall survival in follicular lymphomas. Although rapid rituximab infusions have been studied extensively, there is little data on the use of rapid infusions during maintenance therapy for low grade lymphomas. The primary objective of this retrospective analysis was to evaluate the incidence of Grade 3 and 4 toxicities with maintenance rapid infusion rituximab according to the Common Terminology Criteria for Adverse Events version 4 (CTC v. 4. Secondary objectives included evaluating all grade infusion related adverse events and correlation of adverse events with varying schedules of rituximab maintenance therapy. All patients who received rapid infusion rituximab as maintenance therapy for low grade lymphoma between December 2007 and November 2011 were included. Rapid rituximab infusions were administered over 90 minutes. Demographic, laboratory and clinical data were collected. A total of 109 patients received 647 rapid rituximab infusions. Three patients experienced an adverse reaction which resulted in one grade 1 infusion reaction and three grade 3 infusion reactions. No patients required hospitalization. All 3 patients received pharmacological and/or supportive care to relieve symptoms associated with the reaction.

  15. Discussion on the Performance of Multistage Centrifugal Pumps%多级离心泵性能的探讨

    Institute of Scientific and Technical Information of China (English)

    赵义; 于文华; 宋杨; 蔡亚光

    2011-01-01

    Considering the hydraulic loss, volumetric loss and mechanical loss of factors influencing multistage centrifugal pumps and different factors is revealed, pumps. pumps are presented and the relatio which provides theory basis and methods centrifugal pumps, through experiments, the nship between the efficiency of centrifugal for the efficient use of multistage centrifugal%综合考虑了离心水泵的水力损失、容积损失和机械损失,通过实验提出了影响多级离心泵性能的因素,揭示了离心泵使用效率与各因素的关系,为高效使用多级离心水泵提供了理论依据和方法。

  16. Electrocentrifugal pumping; Bombeo electrocentrifugo

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez Perez, Guillermo; Medellin Otero, Hector [Instituto Mexicano del Peroleo (Mexico)

    1996-07-01

    The exploitation of isolated oil deposits, in losing their own energy, enter a phase of secondary recovery. One of the technologies of new development in Mexico is the one of electrocentrifugal pumping , which consists of introducing the motor-pump as an integral part of the production pipe down to the well bottom and pumping directly up to central complexes, from where it is sent inland. In the present paper is intended to explain what this type of secondary recovery consists of. [Spanish] La explotacion de yacimientos aislados de petroleo, al perder su energia propia, entran en una fase de recuperacion secundaria. Una de las tecnologias de nuevo desarrollo en Mexico es la de bombeo electrocentrifugo, la cual consiste en introducir la motobomba como parte integral de la tuberia de produccion hasta el fondo del pozo y bombearlo directamente hasta los complejos centrales, de donde se envia a tierra. En el presente trabajo se pretende explicar en que consiste este tipo de recuperacion secundaria.

  17. Stirling Engine Heat Pump

    Science.gov (United States)

    Kagawa, Noboru

    Recent advances in the feasibility studies related to the Stirling engines and Stirling engine heat pumps which have been considered attractive due to their promising role in helping to solve the global environmental and energy problems,are reviewed. This article begins to describe the brief history of the Stirling engines and theoretical thermodynamic analysis of the Stirling cycle in order to understand several advantages on the Stirling engine. Furthermore,they could throw light on our question why the dream engines had not been promoted to practical applications during two hundred years. The present review shows that the Stirling engines with several unique advantages including 30 to 40% thermal efficiency and preferable exhaust characteristics,had been designed and constructed by recent tackling for the development of the advanced automobile and other applications using them. Based on the current state of art,it is being provided to push the Stirling engines combined with heat pumps based on the reversed Rankine cycle to the market. At present,however, many problems, especially for the durability, cost, and delicate engine parts must be enforced to solve. In addition,there are some possibilities which can increase the attractiveness of the Stirling engines and heat pumps. The review closes with suggestions for further research.

  18. A Magnetically Coupled Cryogenic Pump

    Science.gov (United States)

    Hatfield, Walter; Jumper, Kevin

    2011-01-01

    Historically, cryogenic pumps used for propellant loading at Kennedy Space Center (KSC) and other NASA Centers have a bellows mechanical seal and oil bath ball bearings, both of which can be problematic and require high maintenance. Because of the extremely low temperatures, the mechanical seals are made of special materials and design, have wearing surfaces, are subject to improper installation, and commonly are a potential leak path. The ball bearings are non-precision bearings [ABEC-1 (Annular Bearing Engineering Council)] and are lubricated using LOX compatible oil. This oil is compatible with the propellant to prevent explosions, but does not have good lubricating properties. Due to the poor lubricity, it has been a goal of the KSC cryogenics community for the last 15 years to develop a magnetically coupled pump, which would eliminate these two potential issues. A number of projects have been attempted, but none of the pumps was a success. An off-the-shelf magnetically coupled pump (typically used with corrosive fluids) was procured that has been used for hypergolic service at KSC. The KSC Cryogenics Test Lab (CTL) operated the pump in cryogenic LN2 as received to determine a baseline for modifications required. The pump bushing, bearings, and thrust rings failed, and the pump would not flow liquid (this is a typical failure mode that was experienced in the previous attempts). Using the knowledge gained over the years designing and building cryogenic pumps, the CTL determined alternative materials that would be suitable for use under the pump design conditions. The CTL procured alternative materials for the bearings (bronze, aluminum bronze, and glass filled PTFE) and machined new bearing bushings, sleeves, and thrust rings. The designed clearances among the bushings, sleeves, thrust rings, case, and case cover were altered once again using experience gained from previous cryogenic pump rebuilds and designs. The alternative material parts were assembled into

  19. Novel anaesthetic approach for surgical access and haemodynamic management during off-pump coronary artery bypass through a left thoracotomy

    Directory of Open Access Journals (Sweden)

    Madan Mohan Maddali

    2012-01-01

    Full Text Available For myocardial revascularization on a beating heart through a thoracotomy, a properly deployed endobronchial blocker (EBB provides ideal conditions for surgical access. In addition, adequate volume replacement to achieve optimal cardiac performance is a primary goal of haemodynamic management in patients undergoing off-pump coronary artery bypass grafting. To achieve both these ends, this case report describes the combined use of a left-sided EBB along with a volumetric pulmonary artery catheter in a patient who underwent a successful off-pump coronary artery bypass surgery through an anterolateral thoracotomy.

  20. Clinical observation of the effect of a totally implantable programmable device for continuous intrathecal infusion in the treatment of intractable neuropathic pain

    Directory of Open Access Journals (Sweden)

    YANG Yang

    2013-09-01

    Full Text Available Objective To observe the curative effect and life quality improvement in patients with intractable neuropathic pain (NP after implanting a programmable continuous intrathecal infusion pump. Methods Three cases of intractable neuropathic pain with poor medicine efficacy or serious adverse drug reactions had been followed-up for 6-14 months after being implanted programmable intrathecal infusion pump. Pain relief, sleep quality improvement, dosage of oral analgesics and drug side effect were observed. Results After treatment the Visual Analogue Scale (VAS of 3 patients decreased significantly, with pain releasing from preoperative moderate or severe pain to postoperative mild pain and decrease of fulminating pain frequency. Dosage of oral analgesics declined to 10% of its preoperative dose and sleep quality was improved obviously. Neither postoperative complications nor side effect of morphine was observed during the follow-up. Conclusion The treatment of implanting a totally programmable continuous intrathecal infusion pump is eutherapeutic to the patients with intractable neuropathic pain who have achieved satisfactory analgesic effect in experimental therapy.

  1. Metal PCP field trial pushes up pumping window for heavy oil hot production : Joslyn field case

    Energy Technology Data Exchange (ETDEWEB)

    Beauquin, J.L.; Ndinemenu, F. [Total SA, Paris (France); Chalier, G. [Total E and P Canada Ltd., Calgary, AB (Canada); Lemay, L.; Seince, L. [PCM, Verves (France); Jahn, S. [Kudu Industries Inc., Calgary, AB (Canada)

    2008-07-01

    This paper presented details of field trials conducted for a novel all-metal progressive cavity pump (PCP) system at a steam assisted gravity drainage (SAGD) facility in Canada's Joslyn field. The fully metallic helical profile was produced by hydro-forming processes. The pump's stator was comprised of 3 elements welded together and coated for high temperature and wear resistance. During the field trials, the well pads were equipped with metal PCPs as well as topside and down hole instrumentation in order to obtain real time well data and pump performance data. Results of the study showed that initial volumetric efficiencies were 55 per cent. When pressure communication between injector and producer wells increased, pump intake pressure and speed also increased. Performance data from the field trial were then compared with results from high temperature electric submersible pumps (ESPs). It was concluded that the metal PCP is a promising artificial lift technology for SAGD processes. The pump design is now being modified to minimize vibrations and improve run life. 1 ref., 11 figs.

  2. Volumetric CT-images improve testing of radiological image interpretation skills

    Energy Technology Data Exchange (ETDEWEB)

    Ravesloot, Cécile J., E-mail: C.J.Ravesloot@umcutrecht.nl [Radiology Department at University Medical Center Utrecht, Heidelberglaan 100, 3508 GA Utrecht, Room E01.132 (Netherlands); Schaaf, Marieke F. van der, E-mail: M.F.vanderSchaaf@uu.nl [Department of Pedagogical and Educational Sciences at Utrecht University, Heidelberglaan 1, 3584 CS Utrecht (Netherlands); Schaik, Jan P.J. van, E-mail: J.P.J.vanSchaik@umcutrecht.nl [Radiology Department at University Medical Center Utrecht, Heidelberglaan 100, 3508 GA Utrecht, Room E01.132 (Netherlands); Cate, Olle Th.J. ten, E-mail: T.J.tenCate@umcutrecht.nl [Center for Research and Development of Education at University Medical Center Utrecht, Heidelberglaan 100, 3508 GA Utrecht (Netherlands); Gijp, Anouk van der, E-mail: A.vanderGijp-2@umcutrecht.nl [Radiology Department at University Medical Center Utrecht, Heidelberglaan 100, 3508 GA Utrecht, Room E01.132 (Netherlands); Mol, Christian P., E-mail: C.Mol@umcutrecht.nl [Image Sciences Institute at University Medical Center Utrecht, Heidelberglaan 100, 3508 GA Utrecht (Netherlands); Vincken, Koen L., E-mail: K.Vincken@umcutrecht.nl [Image Sciences Institute at University Medical Center Utrecht, Heidelberglaan 100, 3508 GA Utrecht (Netherlands)

    2015-05-15

    Rationale and objectives: Current radiology practice increasingly involves interpretation of volumetric data sets. In contrast, most radiology tests still contain only 2D images. We introduced a new testing tool that allows for stack viewing of volumetric images in our undergraduate radiology program. We hypothesized that tests with volumetric CT-images enhance test quality, in comparison with traditional completely 2D image-based tests, because they might better reflect required skills for clinical practice. Materials and methods: Two groups of medical students (n = 139; n = 143), trained with 2D and volumetric CT-images, took a digital radiology test in two versions (A and B), each containing both 2D and volumetric CT-image questions. In a questionnaire, they were asked to comment on the representativeness for clinical practice, difficulty and user-friendliness of the test questions and testing program. Students’ test scores and reliabilities, measured with Cronbach's alpha, of 2D and volumetric CT-image tests were compared. Results: Estimated reliabilities (Cronbach's alphas) were higher for volumetric CT-image scores (version A: .51 and version B: .54), than for 2D CT-image scores (version A: .24 and version B: .37). Participants found volumetric CT-image tests more representative of clinical practice, and considered them to be less difficult than volumetric CT-image questions. However, in one version (A), volumetric CT-image scores (M 80.9, SD 14.8) were significantly lower than 2D CT-image scores (M 88.4, SD 10.4) (p < .001). The volumetric CT-image testing program was considered user-friendly. Conclusion: This study shows that volumetric image questions can be successfully integrated in students’ radiology testing. Results suggests that the inclusion of volumetric CT-images might improve the quality of radiology tests by positively impacting perceived representativeness for clinical practice and increasing reliability of the test.

  3. Research on the method of cavitations resistance in a piezoelectric pump with 3-dimensional mesh structure

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jian-hui; XIA Qi-xiao; Bai Heng-jun; NING Hong-gang; ONUKI Akiyoshi

    2006-01-01

    The volume valve piezoelectric pump has received increasing attention from many areas because of its different characteristics such as the absence of chemical pollution and electromagnetic pollution.However,when the pump is working,it produces cavitations and the air bubbles that originate from these will flow out of the pump.Cavitations occurring in the pump will bring out noise and shorten the life of the pump.Furthermore,air bubbles flowing out of the pump will hinder its application in areas such as medical treatment and health care where blood transfusion and infusion are concerned.As a solution to this disadvantage,the CR3DMS (cavitations resistance with 3-dimensional mesh structure) method is developed,which is tested and verified to be effective on not only reducing the occurrence of cavitations and eliminating cavitations' flowing out,but also restraining the emission of noise.In conclusion,the pump with CR3DMS,on the relationship between flow and driving frequency and the relationship between flow and the number of Resistant-Layers in both theory and test,are analyzed.

  4. Supercritical waste oxidation pump investigation

    Energy Technology Data Exchange (ETDEWEB)

    Thurston, G.; Garcia, K.

    1993-02-01

    This report investigates the pumping techniques and pumping equipment that would be appropriate for a 5,000 gallon per day supercritical water oxidation waste disposal facility. The pumps must boost water, waste, and additives from atmospheric pressure to approximately 27.6 MPa (4,000 psia). The required flow ranges from 10 gpm to less than 0.1 gpm. For the higher flows, many commercial piston pumps are available. These pumps have packing and check-valves that will require periodic maintenance; probably at 2 to 6 month intervals. Several commercial diaphragm pumps were also discovered that could pump the higher flow rates. Diaphragm pumps have the advantage of not requiring dynamic seals. For the lower flows associated with the waste and additive materials, commercial diaphragm pumps. are available. Difficult to pump materials that are sticky, radioactive, or contain solids, could be injected with an accumulator using an inert gas as the driving mechanism. The information presented in this report serves as a spring board for trade studies and the development of equipment specifications.

  5. Family perceptions of insulin pump adverse events in children and adolescents.

    Science.gov (United States)

    Wheeler, Benjamin J; Donaghue, Kim C; Heels, Kristine; Ambler, Geoffrey R

    2014-04-01

    Insulin pumps (for continuous subcutaneous insulin infusion [CSII]) are used widely in type 1 diabetes mellitus. Although there has been considerable study of outcomes, there are few recent data on CSII-associated adverse events and no data on family perceptions of adverse events and their confidence in dealing with them. We approached all families of children and adolescents ≤ 19 years of age on CSII attending the diabetes clinic over a 16-week clinic cycle. Participants completed a retrospective questionnaire examining issues over the previous 12 months. Data on pump adverse events as well as answers to questions pertaining to education and confidence were collected. Our survey received a response rate of 99%, with 235 of the 238 families approached participating. In the preceding 12 months, 104 of 230 (45%) had reported at least one pump-related adverse event (either mechanical or set-related), with an associated 52 of 229 (23%) resulting in pump replacement. This equated to a minimum incidence density of 53 adverse events/100 person-years. Additionally, 18 of 230 (8%) reported a hospital admission or emergency department attendance as a consequence. Pump malfunction and infusion set/site failures were the most common events reported, with one or more events in 58 of 104 (56%) and 47 of 104 (45%), respectively. Adverse events, excluding set/site failures, were associated with older age (13.1 ± 3.4 years vs. 11.9 ± 4 years; P = 0.02). This is the first study to look at family perceptions of adverse events while using modern CSII. It highlights a high self-reported rate of CSII-related adverse events, pump replacement, and subsequent presentation to the hospital. Potential areas for additional targeted education are identified. Further prospective study examining pump adverse event characteristics and incidence is warranted.

  6. One thousand dollar assist heart pump for patients from developing countries.

    Science.gov (United States)

    Qian, Kun-Xi

    2007-06-28

    In spite of continuous improvements in device design and applications, the profound use of heart pump has been limited because of its high price. The available clinically applied heart pump costs mostly about 100 thousands US Dollars. The author has since long tried to develop a heart pump costing only 1000 Dollars for recovery or bridge to heart transplantation therapies. The device is a radially driven centrifugal pump with a brush-less DC motor and a streamlined impeller. Its bearing is rolling bearing using 4 to 6 needles, manufactured by special wear-proof polythene with super-high-molecular weight, thus the service life achieves more than 10 years. To avoid thrombus formation, a special purge system is introduced to the bearing, allowing the saline with heparin to be infused through the bearing into the pump. The bearing, therefore, keeps working in the saline, and absolutely no thrombus will be formed along the bearing. Animal experiments demonstrated that a 30 mL fluid infusion per hour is enough to prevent thrombus formation. With these improvements, the impeller pump has continuously run for 14 months in the laboratory, and no bearing wear can be measured. The device, weighing 150 g, is fully implantable, consumes approximately 9.6 W, delivers a 9Lmin-1 blood flow against a 120 mmHg mean pressure, and reaches a highest total efficiency of 24.7% for the motor (including the controller) and the pump. The device has been used in animal experiments together with an American artificial lung for more than one month in the University of Texas and also in human trials in the Taiwan University.

  7. Personalized heterogeneous deformable model for fast volumetric registration.

    Science.gov (United States)

    Si, Weixin; Liao, Xiangyun; Wang, Qiong; Heng, Pheng Ann

    2017-02-20

    Biomechanical deformable volumetric registration can help improve safety of surgical interventions by ensuring the operations are extremely precise. However, this technique has been limited by the accuracy and the computational efficiency of patient-specific modeling. This study presents a tissue-tissue coupling strategy based on penalty method to model the heterogeneous behavior of deformable body, and estimate the personalized tissue-tissue coupling parameters in a data-driven way. Moreover, considering that the computational efficiency of biomechanical model is highly dependent on the mechanical resolution, a practical coarse-to-fine scheme is proposed to increase runtime efficiency. Particularly, a detail enrichment database is established in an offline fashion to represent the mapping relationship between the deformation results of high-resolution hexahedral mesh extracted from the raw medical data and a newly constructed low-resolution hexahedral mesh. At runtime, the mechanical behavior of human organ under interactions is simulated with this low-resolution hexahedral mesh, then the microstructures are synthesized in virtue of the detail enrichment database. The proposed method is validated by volumetric registration in an abdominal phantom compression experiments. Our personalized heterogeneous deformable model can well describe the coupling effects between different tissues of the phantom. Compared with high-resolution heterogeneous deformable model, the low-resolution deformable model with our detail enrichment database can achieve 9.4× faster, and the average target registration error is 3.42 mm, which demonstrates that the proposed method shows better volumetric registration performance than state-of-the-art. Our framework can well balance the precision and efficiency, and has great potential to be adopted in the practical augmented reality image-guided robotic systems.

  8. Volumetric measurements of pulmonary nodules: variability in automated analysis tools

    Science.gov (United States)

    Juluru, Krishna; Kim, Woojin; Boonn, William; King, Tara; Siddiqui, Khan; Siegel, Eliot

    2007-03-01

    Over the past decade, several computerized tools have been developed for detection of lung nodules and for providing volumetric analysis. Incidentally detected lung nodules have traditionally been followed over time by measurements of their axial dimensions on CT scans to ensure stability or document progression. A recently published article by the Fleischner Society offers guidelines on the management of incidentally detected nodules based on size criteria. For this reason, differences in measurements obtained by automated tools from various vendors may have significant implications on management, yet the degree of variability in these measurements is not well understood. The goal of this study is to quantify the differences in nodule maximum diameter and volume among different automated analysis software. Using a dataset of lung scans obtained with both "ultra-low" and conventional doses, we identified a subset of nodules in each of five size-based categories. Using automated analysis tools provided by three different vendors, we obtained size and volumetric measurements on these nodules, and compared these data using descriptive as well as ANOVA and t-test analysis. Results showed significant differences in nodule maximum diameter measurements among the various automated lung nodule analysis tools but no significant differences in nodule volume measurements. These data suggest that when using automated commercial software, volume measurements may be a more reliable marker of tumor progression than maximum diameter. The data also suggest that volumetric nodule measurements may be relatively reproducible among various commercial workstations, in contrast to the variability documented when performing human mark-ups, as is seen in the LIDC (lung imaging database consortium) study.

  9. Ketamine Infusions for Treatment Refractory Headache.

    Science.gov (United States)

    Pomeroy, Jared L; Marmura, Michael J; Nahas, Stephanie J; Viscusi, Eugene R

    2017-02-01

    Management of chronic migraine (CM) or new daily persistent headache (NDPH) in those who require aggressive outpatient and inpatient treatment is challenging. Ketamine has been suggested as a new treatment for this intractable population. This is a retrospective review of 77 patients who underwent administration of intravenous, subanesthetic ketamine for CM or NDPH. All patients had previously failed aggressive outpatient and inpatient treatments. Records were reviewed for patients treated between January 2006 and December 2014. The mean headache pain rating using a 0-10 pain scale was an average of 7.1 at admission and 3.8 on discharge (P ketamine well. A number of adverse events were observed, but very few were serious. Subanesthetic ketamine infusions may be beneficial in individuals with CM or NDPH who have failed other aggressive treatments. Controlled trials may confirm this, and further studies may be useful in elucidating more robust benefit in a less refractory patient population. © 2016 American Headache Society.

  10. Volumetric hemispheric ratio as a useful tool in personality psychology.

    Science.gov (United States)

    Montag, Christian; Schoene-Bake, Jan-Christoph; Wagner, Jan; Reuter, Martin; Markett, Sebastian; Weber, Bernd; Quesada, Carlos M

    2013-02-01

    The present study investigates the link between volumetric hemispheric ratios (VHRs) and personality measures in N=267 healthy participants using Eysenck's Personality Inventory-Revised (EPQ-R) and the BIS/BAS scales. A robust association between extraversion and VHRs was observed for gray matter in males but not females. Higher gray matter volume in the left than in the right hemisphere was associated with higher extraversion in males. The results are discussed in the context of positive emotionality and laterality of the human brain.

  11. AN ATTRIBUTION OF CAVITATION RESONANCE: VOLUMETRIC OSCILLATIONS OF CLOUD

    Institute of Scientific and Technical Information of China (English)

    ZUO Zhi-gang; LI Sheng-cai; LIU Shu-hong; LI Shuang; CHEN Hui

    2009-01-01

    In order to further verify the proposed theory of cavitation resonance, as well as to proceed the investigations into microscopic level, a series of studies are being carried out on the Warwick venturi. The analysis of the oscillation characteristics of the cavitation resonance has conclusively verified the macro-mechanism proposed through previous studies on other cavitating flows by the authors. The initial observations using high-speed photographic approach have revealed a new attribution of cavitation resonance. That is, the volumetric oscillation of cavitation cloud is associated with the cavitation resonance, which is a collective behaviour of the bubbles in the cloud.

  12. Synthesis of Volumetric Ring Antenna Array for Terrestrial Coverage Pattern

    Directory of Open Access Journals (Sweden)

    Alberto Reyna

    2014-01-01

    Full Text Available This paper presents a synthesis of a volumetric ring antenna array for a terrestrial coverage pattern. This synthesis regards the spacing among the rings on the planes X-Y, the positions of the rings on the plane X-Z, and uniform and concentric excitations. The optimization is carried out by implementing the particle swarm optimization. The synthesis is compared with previous designs by resulting with proper performance of this geometry to provide an accurate coverage to be applied in satellite applications with a maximum reduction of the antenna hardware as well as the side lobe level reduction.

  13. Synthesis of Volumetric Ring Antenna Array for Terrestrial Coverage Pattern

    Science.gov (United States)

    Reyna, Alberto; Panduro, Marco A.; Del Rio Bocio, Carlos

    2014-01-01

    This paper presents a synthesis of a volumetric ring antenna array for a terrestrial coverage pattern. This synthesis regards the spacing among the rings on the planes X-Y, the positions of the rings on the plane X-Z, and uniform and concentric excitations. The optimization is carried out by implementing the particle swarm optimization. The synthesis is compared with previous designs by resulting with proper performance of this geometry to provide an accurate coverage to be applied in satellite applications with a maximum reduction of the antenna hardware as well as the side lobe level reduction. PMID:24701150

  14. Estimation of volumetric breast density for breast cancer risk prediction

    Science.gov (United States)

    Pawluczyk, Olga; Yaffe, Martin J.; Boyd, Norman F.; Jong, Roberta A.

    2000-04-01

    Mammographic density (MD) has been shown to be a strong risk predictor for breast cancer. Compared to subjective assessment by a radiologist, computer-aided analysis of digitized mammograms provides a quantitative and more reproducible method for assessing breast density. However, the current methods of estimating breast density based on the area of bright signal in a mammogram do not reflect the true, volumetric quantity of dense tissue in the breast. A computerized method to estimate the amount of radiographically dense tissue in the overall volume of the breast has been developed to provide an automatic, user-independent tool for breast cancer risk assessment. The procedure for volumetric density estimation consists of first correcting the image for inhomogeneity, then performing a volume density calculation. First, optical sensitometry is used to convert all images to the logarithm of relative exposure (LRE), in order to simplify the image correction operations. The field non-uniformity correction, which takes into account heel effect, inverse square law, path obliquity and intrinsic field and grid non- uniformity is obtained by imaging a spherical section PMMA phantom. The processed LRE image of the phantom is then used as a correction offset for actual mammograms. From information about the thickness and placement of the breast, as well as the parameters of a breast-like calibration step wedge placed in the mammogram, MD of the breast is calculated. Post processing and a simple calibration phantom enable user- independent, reliable and repeatable volumetric estimation of density in breast-equivalent phantoms. Initial results obtained on known density phantoms show the estimation to vary less than 5% in MD from the actual value. This can be compared to estimated mammographic density differences of 30% between the true and non-corrected values. Since a more simplistic breast density measurement based on the projected area has been shown to be a strong indicator

  15. Volumetric 3D Display System with Static Screen

    Science.gov (United States)

    Geng, Jason

    2011-01-01

    Current display technology has relied on flat, 2D screens that cannot truly convey the third dimension of visual information: depth. In contrast to conventional visualization that is primarily based on 2D flat screens, the volumetric 3D display possesses a true 3D display volume, and places physically each 3D voxel in displayed 3D images at the true 3D (x,y,z) spatial position. Each voxel, analogous to a pixel in a 2D image, emits light from that position to form a real 3D image in the eyes of the viewers. Such true volumetric 3D display technology provides both physiological (accommodation, convergence, binocular disparity, and motion parallax) and psychological (image size, linear perspective, shading, brightness, etc.) depth cues to human visual systems to help in the perception of 3D objects. In a volumetric 3D display, viewers can watch the displayed 3D images from a completely 360 view without using any special eyewear. The volumetric 3D display techniques may lead to a quantum leap in information display technology and can dramatically change the ways humans interact with computers, which can lead to significant improvements in the efficiency of learning and knowledge management processes. Within a block of glass, a large amount of tiny dots of voxels are created by using a recently available machining technique called laser subsurface engraving (LSE). The LSE is able to produce tiny physical crack points (as small as 0.05 mm in diameter) at any (x,y,z) location within the cube of transparent material. The crack dots, when illuminated by a light source, scatter the light around and form visible voxels within the 3D volume. The locations of these tiny voxels are strategically determined such that each can be illuminated by a light ray from a high-resolution digital mirror device (DMD) light engine. The distribution of these voxels occupies the full display volume within the static 3D glass screen. This design eliminates any moving screen seen in previous

  16. Potential pitfalls of propofol target controlled infusion delivery related to its pharmacokinetics and pharmacodynamics.

    Science.gov (United States)

    Bienert, Agnieszka; Wiczling, Paweł; Grześkowiak, Edmund; Cywiński, Jacek B Jacek; Kusza, Krzysztof

    2012-01-01

    Target controlled infusion (TCI) devices are increasingly used in clinical practice. These devices unquestionably aid optimization of drug dosage. However, it still remains to be determined if they sufficiently address differences in pharmacological make up of individual patients. The algorithms guiding TCI pumps are based on pharmacological data obtained from a relatively small number of healthy volunteers, which are then extrapolated, on the basis of sophisticated pharmacokinetic and pharmacodynamic modeling, to predict plasma concentrations of the drug and its effect on general population. One has to realize the limitation of this approach: these models may be less accurate when applied to patients in extreme clinical conditions: in intensive care units, with a considerable loss of blood, severe hypothermia or temporary changes in the composition of plasma, e.g., hypoalbuminemia. In the future, data obtained under these "extreme" clinical circumstances, may be used to modify the dosage algorithms of propofol TCI systems to match the clinical scenario.

  17. Direct pumping of four levels lasing materials

    Science.gov (United States)

    Goldring, Sharone; Lavi, Raphael; Tal, Alon; Jackel, Steven M.; Lebiush, Eyal; Tzuk, Yitshak; Azoulay, Ehud

    2003-06-01

    Heat generation and laser performance were studied in Nd:YAG oscillators pumped with a Ti:Sapphire laser in two regimes: band pumping at 802nm and direct pumping at 885nm. Slope efficiencies of 52% and 57%, when pumped at 802nm and 885nm, were obtained, respectively. Heat per unit laser output was found to be 27% lower when pumped at 885nm (direct pumping regime) as compared to traditional band pumping around 808nm.

  18. Effect of perioperative insulin infusion on surgical morbidity and mortality

    DEFF Research Database (Denmark)

    Gandhi, Gunjan Y; Murad, M Hassan; Flynn, Errol David;

    2008-01-01

    To conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the effect of perioperative insulin infusion on outcomes important to patients.......To conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the effect of perioperative insulin infusion on outcomes important to patients....

  19. Silos to Symphonies? Hopes and Challenges Implementing Multicultural Programme Infusion

    Science.gov (United States)

    Liu, Laura B.; Milman, Natalie B.

    2013-01-01

    The need to infuse multicultural education (ME) across teacher preparation programmes is well documented by research, yet institutions are at very different stages in this endeavour. While most programmes demonstrate a segregated approach to ME, confining diversity to specialty courses, ME programme infusion places diversity, equity and social…

  20. Perisciatic infusion of ropivacaine and analgesia after hallux valgus repair

    DEFF Research Database (Denmark)

    Zaric, D; Jørgensen, B G; Laigaard, F;

    2010-01-01

    Moderate to severe pain after hallux valgus repair can be successfully treated with a continuous popliteal sciatic nerve block in ambulatory patients. Different anesthesiologists use various infusion rates for this purpose. The aim of this study was to compare the analgesic efficacy of two infusion...

  1. ArtsIN: Arts Integration and Infusion Framework

    Science.gov (United States)

    Hartle, Lynn C.; Pinciotti, Patricia; Gorton, Rebecca L.

    2015-01-01

    Teaching to meet the diverse learning needs of twenty-first century, global learners can be challenging, yet a growing body of research points to the proved successes of arts-infused and integrated curricula, especially for building capacity for learning and motivation. This article presents the ArtsIN: Arts Integration and Infusion framework, a…

  2. Inhibition of endogenous lactate turnover with lactate infusion in humans

    Energy Technology Data Exchange (ETDEWEB)

    Searle, G.L.; Feingold, K.R.; Hsu, F.S.; Clark, O.H.; Gertz, E.W.; Stanley, W.C. (Veterans Administration Medical Center, San Francisco, CA (USA))

    1989-11-01

    The extent to which lactate infusion may inhibit endogenous lactate production, though previously considered, has never been critically assessed. To examine this proposition, single injection tracer methodology (U-{sup 14}C Lactate) has been used for the estimation of lactate kinetics in 12 human subjects under basal conditions and with the infusion of sodium lactate. The basal rate of lactate turnover was measured on a day before the study with lactate infusion, and averaged 63.7 + 5.5 mg/kg/h. Six of these individuals received a stable lactate infusion at an approximate rate of 160 mg/kg/h, while the remaining six individuals were infused at the approximate rate of 100 mg/kg/h. It has been found that stable lactate infused at rates approximating 160 mg/kg/h consistently produced a complete inhibition of endogenous lactate production. Infusion of lactate at 100 mg/kg/h caused a lesser and more variable inhibition of endogenous lactate production (12% to 64%). In conclusion, lactate infusion significantly inhibits endogenous lactate production.

  3. ArtsIN: Arts Integration and Infusion Framework

    Science.gov (United States)

    Hartle, Lynn C.; Pinciotti, Patricia; Gorton, Rebecca L.

    2015-01-01

    Teaching to meet the diverse learning needs of twenty-first century, global learners can be challenging, yet a growing body of research points to the proved successes of arts-infused and integrated curricula, especially for building capacity for learning and motivation. This article presents the ArtsIN: Arts Integration and Infusion framework, a…

  4. Floating volumetric image formation using a dihedral corner reflector array device.

    Science.gov (United States)

    Miyazaki, Daisuke; Hirano, Noboru; Maeda, Yuki; Yamamoto, Siori; Mukai, Takaaki; Maekawa, Satoshi

    2013-01-01

    A volumetric display system using an optical imaging device consisting of numerous dihedral corner reflectors placed perpendicular to the surface of a metal plate is proposed. Image formation by the dihedral corner reflector array (DCRA) is free from distortion and focal length. In the proposed volumetric display system, a two-dimensional real image is moved by a mirror scanner to scan a three-dimensional (3D) space. Cross-sectional images of a 3D object are displayed in accordance with the position of the image plane. A volumetric image is observed as a stack of the cross-sectional images. The use of the DCRA brings compact system configuration and volumetric real image generation with very low distortion. An experimental volumetric display system including a DCRA, a galvanometer mirror, and a digital micro-mirror device was constructed to verify the proposed method. A volumetric image consisting of 1024×768×400 voxels was formed by the experimental system.

  5. Proper Sizing of Circulation Pumps

    DEFF Research Database (Denmark)

    Tommerup, Henrik M.; Nørgaard, Jørgen

    2007-01-01

    , but the results can be applied to Europe in general. Despite the small sample of houses involved in the test, 15 houses, some rather safe conclusions can be drawn from the results, which showed that newly developed pumps with power consumption around 5-8 W, can perform the task of circulating the water...... sufficiently to keep the houses satisfactorily warm during the heating season of the test. The old replaced pumps used 5-10 times more power. In Europe alone, a gradual replacement of the present vastly oversized pumps with such small but sufficient pumps can save the construction of 17 large power plants...... as well as their pollution during operation. Policy measures are proposed of how to ensure that in the future only such energy saving pumps are installed. Furthermore, on the basis of the historic experiences with circulation pumps some con¬clusions are drawn on how to investigate, develop and market new...

  6. Research on synchronous gear pump

    Institute of Scientific and Technical Information of China (English)

    LUAN Zhen-hui

    2010-01-01

    Based on a comprehensive analysis of the structure and existing problems of the gear pump, provided a structure principle of a synchronous gear pump. The discussions focused on the working principle, construction features and finite element analysis of the hydraulic gear. The research indicates that the new pump has such advantages as lower noise, better distributed flow and a high work pressure, and it can be widely used in hydraulic systems.

  7. Centrifugal pumps and allied machinery

    CERN Document Server

    Anderson, HH

    1994-01-01

    This book will be of vital interest to all engineers and designers concerned with centrifugal pumps and turbines. Including statistical information derived from 20000 pumps and 700 turbines with capacities of 5gpm to 5000000gpm, this book offers the widest range and scope of information currently available. Statistical analyses suggest practical methods of increasing pump performance and provide valuable data for new design aspects.

  8. Accelerated infliximab infusions for inflammatory bowel disease improve effectiveness

    Institute of Scientific and Technical Information of China (English)

    John; McConnell; Simona; Parvulescu-Codrea; Brian; Behm; Beth; Hill; Elizabeth; Dunkle; Karen; Finke; Kathryn; Snyder; Anne; Tuskey; Debbie; Cox; Beth; Woodward

    2012-01-01

    AIM:To study the safety and effectiveness associated with accelerated infliximab infusion protocols in patients with inflammatory bowel disease(IBD).METHODS:Original protocols and infusion rates were developed for the administration of infliximab over 90-min and 60-min.Then the IBD patients on stable maintenance infliximab therapy were offered accelerated infusions.To be eligible for the study,patients needed a minimum of four prior infusions.An initial infusion of 90-min was given to each patient;those tolerating the accelerated infusion were transitioned to a 60-min infusion protocol at their next and all subsequent visits.Any patient having significant infusion reactions would be reverted to the standard 120-min protocol.A change in a patient’s dose mandated a single 120-min infusion before accelerated infusions could be administered again.RESULTS:The University of Virginia Medical Center’s Institutional Review Board approved this study.Fifty IBD patients treated with infliximab 5mg/kg,7.5mg/kg and 10mg/kg were offered accelerated infusions.Forty-six patients consented to participate in the study.Nineteen(41.3%) were female,five(10.9%) were African American and nine(19.6%) had ulcerative colitis.The mean age was 42.6 years old.Patients under age 18 were excluded.Ten patients used immunosuppressive drugs concurrently out of which six were taking azathioprine,three were taking 6-mercaptopurine and one was taking methotrexate.One of the 46 study patients used corticosteroid therapy for his IBD.Seventeen of the patients used prophylactic medications prior to receiving infusions;six patients received corticosteroids as pre-medication.Four patients had a history of distant transfusion reactions to infliximab.These reactions included shortness of breath,chest tightness,flushing,pruritus and urticaria.These patients all took prophylactic medications before receiving infusions.46 patients(27 males and 19 females) received a total of fifty 90-min infusions and ninety

  9. Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-β Peptide in Mice

    Science.gov (United States)

    Morzelle, Maressa Caldeira; Salgado, Jocelem Mastrodi; Telles, Milena; Mourelle, Danilo; Bachiega, Patricia; Buck, Hudson Sousa

    2016-01-01

    Alzheimer’s disease is a chronic and degenerative condition that had no treatment until recently. The current therapeutic strategies reduce progression of the disease but are expensive and commonly cause side effects that are uncomfortable for treated patients. Functional foods to prevent and/or treat many conditions, including neurodegenerative diseases, represent a promising field of study currently gaining attention. To this end, here we demonstrate the effects of pomegranate (Punica granatum) peel extract (PPE) regarding spatial memory, biomarkers of neuroplasticity, oxidative stress and inflammation in a mouse model of neurodegeneration. Male C57Bl/6 mice were chronically infused for 35 days with amyloid-β peptide 1–42 (Aβ) or vehicle (control) using mini-osmotic pumps. Another group, also infused with Aβ, was treated with PPE (p.o.– βA+PPE, 800 mg/kg/day). Spatial memory was evaluated in the Barnes maze. Animals treated with PPE and in the control group exhibited a reduction in failure to find the escape box, a finding that was not observed in the Aβ group. The consumption of PPE reduced amyloid plaque density, increased the expression of neurotrophin BDNF and reduced the activity of acetylcholinesterase enzyme. A reduction in lipid peroxidation and in the concentration of the pro-inflammatory cytokine TNF-α was also observed in the PPE group. No hepatic lesions were observed in animals treated with PPE. In conclusion, administration of pomegranate peel extract has neuroprotective effects involving multiple mechanisms to prevent establishment and progression of the neurodegenerative process induced by infusion with amyloid-β peptide in mice. PMID:27829013

  10. Positron emission tomography and target-controlled infusion for precise modulation of brain drug concentration

    Energy Technology Data Exchange (ETDEWEB)

    Eriksson, Olof [Uppsala Imanet AB, 751 85 Uppsala (Sweden); Department of Radiology, Oncology and Clinical Immunology, Division of Radiology, Uppsala University, 751 85 Uppsala (Sweden)], E-mail: olof.eriksson@uppsala.imanet.se; Josephsson, Ray [Clinical Imaging Unit, Novartis Pharma AG, CH 9057 Basel (Switzerland); Langstrom, Bengt [Uppsala Imanet AB, 751 85 Uppsala (Sweden); Bergstroem, Mats [Department of Pharmaceutical Biosciences, Faculty of Pharmacy, Uppsala University, 751 24 Uppsala (Sweden)

    2008-04-15

    Introduction: There are several instances when it is desirable to control brain concentration of pharmaceuticals, e.g., to modulate the concentration of anesthetic agents to different desired levels fitting to different needs during the course of surgery. This has so far only been possible using indirect estimates of drug concentration such as assuming constant relation between tissue and blood including extrapolations from animals. Methods: A system for controlling target tissue concentration (UIPump) was used to regulate whole-brain concentrations of a central benzodiazepine receptor antagonist at therapeutic levels with input from brain kinetics as determined with PET. The system was tested by using pharmacological doses of flumazenil mixed with tracer amounts of [{sup 11}C]flumazenil. Flumazenil was used as a model compound for anesthesia. An infusion scheme to produce three different steady-state levels in sequence was designed based on kinetic curves obtained after bolus injection. The subjects (Sprague-Dawley rats, n=6) were monitored in a microPET scanner during the whole experiment to verify resulting brain kinetic curves. Results: A steady-state brain concentration was rapidly achieved corresponding to a whole-brain concentration of 118{+-}6 ng/ml. As the infusion rate decreased to lower the exposure by a factor of 2, the brain concentration decreased to 56{+-}4 ng/ml. A third increased steady-state level of anesthesia corresponding to a whole-brain concentration of 107{+-}7 ng/ml was rapidly achieved. Conclusion: The experimental setup with computerized pump infusion and PET supervision enables accurate setting of target tissue drug concentration.

  11. Type of homogenization and fat loss during continuous infusion of human milk.

    Science.gov (United States)

    García-Lara, Nadia Raquel; Escuder-Vieco, Diana; Alonso Díaz, Clara; Vázquez Román, Sara; De la Cruz-Bértolo, Javier; Pallás-Alonso, Carmen Rosa

    2014-11-01

    Substantial fat loss may occur during continuous feeding of human milk (HM). A decrease of fat loss has been described following homogenization. Well-established methods of homogenization of HM for routine use in the neonatal intensive care unit (NICU) would be desirable. We compared the loss of fat based on the use of 3 different methods for homogenizing thawed HM during continuous feeding. Sixteen frozen donor HM samples were thawed, homogenized with ultrasound and separated into 3 aliquots ("baseline agitation," "hourly agitation," and "ultrasound"), and then frozen for 48 hours. Aliquots were thawed again and a baseline agitation was applied. Subsequently, aliquots baseline agitation and hourly agitation were drawn into a syringe, while ultrasound was applied to aliquot ultrasound before it was drawn into a syringe. The syringes were loaded into a pump (2 mL/h; 4 hours). At hourly intervals the hourly agitation infusion was stopped, the syringe was disconnected and gently shaken. During infusion, samples from the 3 groups were collected hourly for analysis of fat and caloric content. The 3 groups of homogenization showed similar fat content at the beginning of the infusion. For fat, mean (SD) hourly changes of -0.03 (0.01), -0.09 (0.01), and -0.09 (0.01) g/dL were observed for the hourly agitation, baseline agitation, and ultrasound groups, respectively. The decrease was smaller for the hourly agitation group (P fat loss is observed when syringes are agitated hourly versus when ultrasound or a baseline homogenization is used. © The Author(s) 2014.

  12. HEMODYNAMIC AND STRUCTURAL MODIFICATIONS IN CONTINUOUS INFUSION WITH ANGIOTENSIN. II. AN EXPERIMENTAL STUDY

    Directory of Open Access Journals (Sweden)

    Minela Aida Maranduca

    2011-09-01

    Full Text Available The renin-angiotensin-aldosterone system (RAAS is a hormonal system which contributes to the regulation of both arterial pressure and extra cellular fluids volume. The increase of RAAS, especially at angiotensin II (Ang II level, affects the target organs and increases the risk of cardio-vascular issues, by increasing arterial pressure and through the direct effect of Ang II upon the vascular endothelium and the renal and cardiac tissue. Ang II reduces the renal capacity of sodium excretion and initiates a set of events which increase arterial pressure. Increase of arterial pressure is necessary for re-establishing sodium excretion, being realized by the pressure-natriuresis relationship. Arterial hypertension affects the target organs (heart, kidneys and leads to a vicious circle which contributes to maintaining a high arterial pressure. Materials and Method: Male Wistar rats subjected on a normal diet, received either a sham operation (n=9 or continuous angiotensin II (Ang II infusion (300ng/kgc/ min subcutaneously, via mini pumps. Water ingestion and systolic blood pressure were measured for 14 days, after which the animals were sacrificed under anesthesia with ketamin, and the xylasin body weight, water ingestion, heart mass, right and left ventricular mass, right and left kidney mass were measured. Results: After 14 days of Ang II infusion, bodily weight decreased, systolic blood pressure increased, heart and left ventricular mass indexed to body weight were significantly enhanced compared with the sham group, and kidneys mass indexed to body weight was similar in the two groups.

  13. Iron removal therapy in porphyria cutanea tarda: phlebotomy versus slow subcutaneous desferrioxamine infusion.

    Science.gov (United States)

    Rocchi, E; Gibertini, P; Cassanelli, M; Pietrangelo, A; Borghi, A; Pantaleoni, M; Jensen, J; Ventura, E

    1986-05-01

    Twenty-five patients with overt clinical and biochemical findings of porphyria cutanea tarda took part in a study comparing intensive phlebotomy with slow subcutaneous desferrioxamine treatment. Fifteen male patients (Group A) had intensive venesection therapy. Ten patients (Group B) with associated diseases (minor thalassemia, cardiovascular impairment, pulmonary tuberculosis or severe liver cirrhosis) received 1.5 g of desferrioxamine by slow subcutaneous infusion using an automatic syringe pump 5 days a week. No patient complained of appreciable side effects. Serum iron, ferritin and uroporphyrins were normalized in all subjects by the end of treatment. The mean time necessary for complete recovery was 13.8 months (range 9-19) and 11.2 months (range 6-14) in Groups A and B, respectively. Liver function significantly improved during and after the treatments in both groups. We conclude that recovery from porphyria cutanea tarda can be achieved equally well using phlebotomy or desferrioxamine subcutaneous infusion. Phlebotomy is easily performed and remains the treatment of choice; slow subcutaneous desferrioxamine treatment, although expensive, is recommended when severe associated diseases contra-indicate venesection.

  14. Evaluation of maternal infusion therapy during pregnancy for fetal development

    Directory of Open Access Journals (Sweden)

    2005-10-01

    Full Text Available The aim of this project was to study the possible association between maternal infusion treatments during pregnancy and variables of fetal development as well as the occurrence of congenital abnormalities (CA in a case-control design. The large population-based data set of the Hungarian Case‑Control Surveillance of Congenital Abnormalities (HCCSCA was evaluated based on the medically recorded infusion treatment during pregnancy. Of 22,843 case pregnant women who had newborns or fetuses with congenital abnormalities, 112 (0.5%, while of 38,151 control pregnant women who had newborn infants without any defects, 262 (0.7%, had infusion treatment during pregnancy. Infusion treatment was more frequent in the control group than in the case group with congenital abnormalities (adjusted POR with 945 95% CI: 0.7, 0.6-0.9 and there was no higher rate of maternal infusion treatments in any congenital abnormality group. Mean gestational age was shorter and mean birth weight was smaller in control newborn infants without CA born to mothers with infusion treatment during pregnancy than in the babies of mothers without infusion treatment. The prevalence of mild intrauterine growth retardation was more frequent in the fetuses of pregnant women with hyperemesis gravidarum treated with infusion. The results of the study suggest that infusion treatment of pregnant women did not associate with a higher risk of congenital abnormalities. In addition, the intravenous infusion of drugs has some, but limited efficacy to prevent the adverse effects of hyperemesis gravidarum and threatened preterm delivery.

  15. Volumetric display containing multiple two-dimensional color motion pictures

    Science.gov (United States)

    Hirayama, R.; Shiraki, A.; Nakayama, H.; Kakue, T.; Shimobaba, T.; Ito, T.

    2014-06-01

    We have developed an algorithm which can record multiple two-dimensional (2-D) gradated projection patterns in a single three-dimensional (3-D) object. Each recorded pattern has the individual projected direction and can only be seen from the direction. The proposed algorithm has two important features: the number of recorded patterns is theoretically infinite and no meaningful pattern can be seen outside of the projected directions. In this paper, we expanded the algorithm to record multiple 2-D projection patterns in color. There are two popular ways of color mixing: additive one and subtractive one. Additive color mixing used to mix light is based on RGB colors and subtractive color mixing used to mix inks is based on CMY colors. We made two coloring methods based on the additive mixing and subtractive mixing. We performed numerical simulations of the coloring methods, and confirmed their effectiveness. We also fabricated two types of volumetric display and applied the proposed algorithm to them. One is a cubic displays constructed by light-emitting diodes (LEDs) in 8×8×8 array. Lighting patterns of LEDs are controlled by a microcomputer board. The other one is made of 7×7 array of threads. Each thread is illuminated by a projector connected with PC. As a result of the implementation, we succeeded in recording multiple 2-D color motion pictures in the volumetric displays. Our algorithm can be applied to digital signage, media art and so forth.

  16. Volumetric three-dimensional display system with rasterization hardware

    Science.gov (United States)

    Favalora, Gregg E.; Dorval, Rick K.; Hall, Deirdre M.; Giovinco, Michael; Napoli, Joshua

    2001-06-01

    An 8-color multiplanar volumetric display is being developed by Actuality Systems, Inc. It will be capable of utilizing an image volume greater than 90 million voxels, which we believe is the greatest utilizable voxel set of any volumetric display constructed to date. The display is designed to be used for molecular visualization, mechanical CAD, e-commerce, entertainment, and medical imaging. As such, it contains a new graphics processing architecture, novel high-performance line- drawing algorithms, and an API similar to a current standard. Three-dimensional imagery is created by projecting a series of 2-D bitmaps ('image slices') onto a diffuse screen that rotates at 600 rpm. Persistence of vision fuses the slices into a volume-filling 3-D image. A modified three-panel Texas Instruments projector provides slices at approximately 4 kHz, resulting in 8-color 3-D imagery comprised of roughly 200 radially-disposed slices which are updated at 20 Hz. Each slice has a resolution of 768 by 768 pixels, subtending 10 inches. An unusual off-axis projection scheme incorporating tilted rotating optics is used to maintain good focus across the projection screen. The display electronics includes a custom rasterization architecture which converts the user's 3- D geometry data into image slices, as well as 6 Gbits of DDR SDRAM graphics memory.

  17. Myocardial kinematics based on tagged MRI from volumetric NURBS models

    Science.gov (United States)

    Tustison, Nicholas J.; Amini, Amir A.

    2004-04-01

    We present current research in which left ventricular deformation is estimated from tagged cardiac magnetic resonance imaging using volumetric deformable models constructed from nonuniform rational B-splines (NURBS). From a set of short and long axis images at end-diastole, the initial NURBS model is constructed by fitting two surfaces with the same parameterization to the set of epicardial and endocardial contours from which a volumetric model is created. Using normal displacements of the three sets of orthogonal tag planes as well as displacements of both tag line and contour/tag line intersection points, one can solve for the optimal homogeneous coordinates, in a least squares sense, of the control points of the NURBS model at a later time point using quadratic programming. After fitting to all time points of data, lofting the NURBS model at each time point creates a comprehensive 4-D NURBS model. From this model, we can extract 3-D myocardial displacement fields and corresponding strain maps, which are local measures of non-rigid deformation.

  18. Volumetric breast density affects performance of digital screening mammography.

    Science.gov (United States)

    Wanders, Johanna O P; Holland, Katharina; Veldhuis, Wouter B; Mann, Ritse M; Pijnappel, Ruud M; Peeters, Petra H M; van Gils, Carla H; Karssemeijer, Nico

    2017-02-01

    To determine to what extent automatically measured volumetric mammographic density influences screening performance when using digital mammography (DM). We collected a consecutive series of 111,898 DM examinations (2003-2011) from one screening unit of the Dutch biennial screening program (age 50-75 years). Volumetric mammographic density was automatically assessed using Volpara. We determined screening performance measures for four density categories comparable to the American College of Radiology (ACR) breast density categories. Of all the examinations, 21.6% were categorized as density category 1 ('almost entirely fatty') and 41.5, 28.9, and 8.0% as category 2-4 ('extremely dense'), respectively. We identified 667 screen-detected and 234 interval cancers. Interval cancer rates were 0.7, 1.9, 2.9, and 4.4‰ and false positive rates were 11.2, 15.1, 18.2, and 23.8‰ for categories 1-4, respectively (both p-trend density categories: 85.7, 77.6, 69.5, and 61.0% for categories 1-4, respectively (p-trend density, automatically measured on digital mammograms, impacts screening performance measures along the same patterns as established with ACR breast density categories. Since measuring breast density fully automatically has much higher reproducibility than visual assessment, this automatic method could help with implementing density-based supplemental screening.

  19. Volumetric properties of human islet amyloid polypeptide in liquid water.

    Science.gov (United States)

    Brovchenko, I; Andrews, M N; Oleinikova, A

    2010-04-28

    The volumetric properties of human islet amyloid polypeptide (hIAPP) in water were studied in a wide temperature range by computer simulations. The intrinsic density rho(p) and the intrinsic thermal expansion coefficient alpha(p) of hIAPP were evaluated by taking into account the difference between the volumetric properties of hydration and bulk water. The density of hydration water rho(h) was found to decrease almost linearly with temperature upon heating and its thermal expansion coefficient was found to be notably higher than that of bulk water. The peptide surface exposed to water is more hydrophobic and its rho(h) is smaller in conformation with a larger number of intrapeptide hydrogen bonds. The two hIAPP peptides studied (with and without disulfide bridge) show negative alpha(p), which is close to zero at 250 K and decreases to approximately -1.5 x 10(-3) K(-1) upon heating to 450 K. The analysis of various structural properties of peptides shows a correlation between the intrinsic peptide volumes and the number of intrapeptide hydrogen bonds. The obtained negative values of alpha(p) can be attributed to the shrinkage of the inner voids of the peptides upon heating.

  20. Volumetric verification of multiaxis machine tool using laser tracker.

    Science.gov (United States)

    Aguado, Sergio; Samper, David; Santolaria, Jorge; Aguilar, Juan José

    2014-01-01

    This paper aims to present a method of volumetric verification in machine tools with linear and rotary axes using a laser tracker. Beyond a method for a particular machine, it presents a methodology that can be used in any machine type. Along this paper, the schema and kinematic model of a machine with three axes of movement, two linear and one rotational axes, including the measurement system and the nominal rotation matrix of the rotational axis are presented. Using this, the machine tool volumetric error is obtained and nonlinear optimization techniques are employed to improve the accuracy of the machine tool. The verification provides a mathematical, not physical, compensation, in less time than other methods of verification by means of the indirect measurement of geometric errors of the machine from the linear and rotary axes. This paper presents an extensive study about the appropriateness and drawbacks of the regression function employed depending on the types of movement of the axes of any machine. In the same way, strengths and weaknesses of measurement methods and optimization techniques depending on the space available to place the measurement system are presented. These studies provide the most appropriate strategies to verify each machine tool taking into consideration its configuration and its available work space.

  1. The Volumetric Rate of Superluminous Supernovae at z~1

    CERN Document Server

    Prajs, S; Smith, M; Levan, A; Karpenka, N V; Edwards, T D P; Walker, C R; Wolf, W M; Balland, C; Carlberg, R; Howell, A; Lidman, C; Pain, R; Pritchet, C; Ruhlmann-Kleider, V

    2016-01-01

    We present a measurement of the volumetric rate of superluminous supernovae (SLSNe) at z~1, measured using archival data from the first four years of the Canada-France-Hawaii Telescope Supernova Legacy Survey (SNLS). We develop a method for the photometric classification of SLSNe to construct our sample. Our sample includes two previously spectroscopically-identified objects, and a further new candidate selected using our classification technique. We use the point-source recovery efficiencies from Perrett et.al. (2010) and a Monte Carlo approach to calculate the rate based on our SLSN sample. We find that the three identified SLSNe from SNLS give a rate of 91 (+76/-36) SNe/Yr/Gpc^3 at a volume-weighted redshift of z=1.13. This is equivalent to 2.2 (+1.8/-0.9) x10^-4 of the volumetric core collapse supernova rate at the same redshift. When combined with other rate measurements from the literature, we show that the rate of SLSNe increases with redshift in a manner consistent with that of the cosmic star formati...

  2. Low-dose copper infusion into the coronary circulation induces acute heart failure in diabetic rats: New mechanism of heart disease.

    Science.gov (United States)

    Cheung, Carlos Chun Ho; Soon, Choong Yee; Chuang, Chia-Lin; Phillips, Anthony R J; Zhang, Shaoping; Cooper, Garth J S

    2015-09-01

    Diabetes impairs copper (Cu) regulation, causing elevated serum Cu and urinary Cu excretion in patients with established cardiovascular disease; it also causes cardiomyopathy and chronic cardiac impairment linked to defective Cu homeostasis in rats. However, the mechanisms that link impaired Cu regulation to cardiac dysfunction in diabetes are incompletely understood. Chronic treatment with triethylenetetramine (TETA), a Cu²⁺-selective chelator, improves cardiac function in diabetic patients, and in rats with heart disease; the latter displayed ∼3-fold elevations in free Cu²⁺ in the coronary effluent when TETA was infused into their coronary arteries. To further study the nature of defective cardiac Cu regulation in diabetes, we employed an isolated-perfused, working-heart model in which we infused micromolar doses of Cu²⁺ into the coronary arteries and measured acute effects on cardiac function in diabetic and non-diabetic-control rats. Infusion of CuCl₂ solutions caused acute dose-dependent cardiac dysfunction in normal hearts. Several measures of baseline cardiac function were impaired in diabetic hearts, and these defects were exacerbated by low-micromolar Cu²⁺ infusion. The response to infused Cu²⁺ was augmented in diabetic hearts, which became defective at lower infusion levels and underwent complete pump failure (cardiac output = 0 ml/min) more often (P hearts. To our knowledge, this is the first report describing the acute effects on cardiac function of pathophysiological elevations in coronary Cu²⁺. The effects of Cu²⁺ infusion occur within minutes in both control and diabetic hearts, which suggests that they are not due to remodelling. Heightened sensitivity to the acute effects of small elevations in Cu²⁺ could contribute substantively to impaired cardiac function in patients with diabetes and is thus identified as a new mechanism of heart disease. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. The relative effectiveness of pumps over MDI and structured education (REPOSE) : study protocol for a cluster randomised controlled trial

    OpenAIRE

    White, David; Waugh, Norman; Elliott, Jackie; Lawton, Julia; Barnard, Katharine D.; Campbell, Michael J; Dixon, S.; Heller, Simon

    2014-01-01

    Introduction: People with type 1 diabetes (T1DM)\\ud require insulin therapy to sustain life, and need optimal\\ud glycaemic control to prevent diabetic ketoacidosis and\\ud serious long-term complications. Insulin is generally\\ud administered using multiple daily injections but can also\\ud be delivered using an infusion pump (continuous\\ud subcutaneous insulin infusion), a more costly option\\ud with benefits for some patients. The UK National\\ud Institute for Health and Care Excellence (NICE)\\u...

  4. Theoretical Prediction of the Pumping Performance of Dry Pumps (Taking the Scroll Pump and the Screw Pump by Way of Example)

    Science.gov (United States)

    Sawada, Tadashi; Ohbayashi, Tetsuro

    Since almost all commercially provided dry pumps are of the positive displacement type, the leak flow through clearance between displacement chambers in the pump is a dominant factor which determines pumping performance. Prediction methods for the pumping performance of dry pumps are explained by comparing it to the scroll pump and the screw pump. The scroll pump has long clearances, but the screw pump has relatively short ones, and the volume of the chambers reduces from the inlet toward the outlet in the scroll pump, but that in the screw pump is kept constant throughout the pumping process. Such a structural difference produces a small difference in the way of treating leak flow. These two methods can be applied to the other dry pumps requiring only minor modification.

  5. Lasers with nuclear pumping

    CERN Document Server

    Melnikov, S P; Sizov, A N; Miley, George H

    2015-01-01

    This book covers the history of lasers with nuclear pumping (Nuclear Pumped Lasers, NPLs). This book showcases the most important results and stages of NPL development in The Russian Federal Nuclear Center (VNIIEF) as well as other Russian and international laboratories, including laboratories in the United States. The basic science and technology behind NPLs along with potential applications are covered throughout the book. As such, this book: ·         Contains a historical overview of the extensive information developed over the past 40 years of work on NPLs ·         Covers the most important results and stages of NPL development, not just in the Russian Federal Nuclear Center, VNIIEF, but also in other laboratories in Russia, the United States , and some other scattered international laboratories ·         Systematizes the fragmented information accumulated over these years of very active research and development As the first comprehensive discussion of NPLs, students, research...

  6. The terrestrial silica pump.

    Directory of Open Access Journals (Sweden)

    Joanna C Carey

    Full Text Available Silicon (Si cycling controls atmospheric CO(2 concentrations and thus, the global climate, through three well-recognized means: chemical weathering of mineral silicates, occlusion of carbon (C to soil phytoliths, and the oceanic biological Si pump. In the latter, oceanic diatoms directly sequester 25.8 Gton C yr(-1, accounting for 43% of the total oceanic net primary production (NPP. However, another important link between C and Si cycling remains largely ignored, specifically the role of Si in terrestrial NPP. Here we show that 55% of terrestrial NPP (33 Gton C yr(-1 is due to active Si-accumulating vegetation, on par with the amount of C sequestered annually via marine diatoms. Our results suggest that similar to oceanic diatoms, the biological Si cycle of land plants also controls atmospheric CO(2 levels. In addition, we provide the first estimates of Si fixed in terrestrial vegetation by major global biome type, highlighting the ecosystems of most dynamic Si fixation. Projected global land use change will convert forests to agricultural lands, increasing the fixation of Si by land plants, and the magnitude of the terrestrial Si pump.

  7. Analysis of event logs from syringe pumps: a retrospective pilot study to assess possible effects of syringe pumps on safety in a university hospital critical care unit in Germany.

    Science.gov (United States)

    Kastrup, Marc; Balzer, Felix; Volk, Thomas; Spies, Claudia

    2012-07-01

    Medication errors occur in approximately one out of five doses in a typical hospital setting. Patients in the intensive care unit (ICU) are particularly susceptible to errors during the application of intravenous drugs as they receive numerous potent drugs applied by syringe pumps. The aim of this study was to analyse the effects on potential harmful medication errors and to address factors that have potential for improving medication safety after the introduction of a standardized drug library into syringe pumps with integrated decision support systems. A team of physicians and nurses developed a dataset that defined standardized drug concentrations, application rates and alert limits to prevent accidental overdosing of intravenous medications. This dataset was implemented in 100 syringe pumps with the ability to log programming errors, alerts, reprogramming events and overrides ('smart pumps'). In this retrospective pilot study, all pump-related transaction data were obtained from the pump logs, by downloading the data from the pumps, covering 20 months of use between 1 April 2008 and 30 November 2009. Patient data were gathered from the electronic patient charts. The study was performed in a cardiothoracic ICU of the Charité University Hospital, Berlin, Germany. A total of 7884 patient treatment days and 133,601 infusion starts were evaluated. The drug library with the features of the dose rate was used in 92.8% of the syringe pump starts, in 1.5% of the starts a manual dosing mode without the use of the drug library was used and in 5.7% of the starts the mode 'mL/h', without any calculation features, was used. The most frequently used drugs were vasoactive drugs, followed by sedation medication. The user was alerted for a potentially harmful overdosing in 717 cases and in 66 cases the pumps were reprogrammed after the alert. During the early morning hours a higher rate of alarms was generated by the pumps, compared with the rest of the day. Syringe pumps with

  8. Diode-pumped laser with improved pumping system

    Science.gov (United States)

    Chang, Jim J.

    2004-03-09

    A laser wherein pump radiation from laser diodes is delivered to a pump chamber and into the lasing medium by quasi-three-dimensional compound parabolic concentrator light channels. The light channels have reflective side walls with a curved surface and reflective end walls with a curved surface. A flow tube between the lasing medium and the light channel has a roughened surface.

  9. 33 CFR 157.126 - Pumps.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Pumps. 157.126 Section 157.126... Washing (COW) System on Tank Vessels Design, Equipment, and Installation § 157.126 Pumps. (a) Crude oil must be supplied to the COW machines by COW system pumps or cargo pumps. (b) The pumps under...

  10. Design of Pumps for Water Hydraulic Systems

    DEFF Research Database (Denmark)

    Klit, Peder; Olsen, Stefan; Bech, Thomas Nørgaard

    1999-01-01

    This paper considers the development of two pumps for water hydraulic applications. The pumps are based on two different working principles: The Vane-type pump and the Gear-type pump. Emphasis is put on the considerations that should be made to account for water as the hydraulic fluid.......KEYWORDS: water, pump, design, vane, gear....

  11. About Variable Speed Heating and Cooling Pumps

    OpenAIRE

    Cătălin Popovici; Jan Ignat

    2009-01-01

    The present work has the purpose of underlying the advantages of variable speed heating and cooling pumps use for the perspective of general and particular pumping costs and efficiency. The study approaches comparisons between constant flow pumps and variable flow pumps in different given situations and comparatively analyses the pumping costs.

  12. 46 CFR 119.520 - Bilge pumps.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Bilge pumps. 119.520 Section 119.520 Shipping COAST... Ballast Systems § 119.520 Bilge pumps. (a) Each vessel must be provided with bilge pumps in accordance... have a portable hand bilge pump that must be: (1) Capable of pumping water, but not...

  13. 46 CFR 154.1135 - Pumps.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Pumps. 154.1135 Section 154.1135 Shipping COAST GUARD... Pumps. (a) Water to the water spray system must be supplied by: (1) A pump that is only for the use of the system; (2) A fire pump; or (3) A pump specially approved by the Commandant (CG-522)....

  14. Heat-Powered Pump for Liquid Metals

    Science.gov (United States)

    Campana, R. J.

    1986-01-01

    Proposed thermoelectromagnetic pump for liquid metal powered by waste heat; needs no battery, generator, or other external energy source. Pump turns part of heat in liquid metal into pumping energy. In combination with primary pump or on its own, thermoelectric pump circulates coolant between reactor and radiator. As long as there is decay heat to be removed, unit performs function.

  15. Heat-Powered Pump for Liquid Metals

    Science.gov (United States)

    Campana, R. J.

    1986-01-01

    Proposed thermoelectromagnetic pump for liquid metal powered by waste heat; needs no battery, generator, or other external energy source. Pump turns part of heat in liquid metal into pumping energy. In combination with primary pump or on its own, thermoelectric pump circulates coolant between reactor and radiator. As long as there is decay heat to be removed, unit performs function.

  16. Comparison Of The Powers Of Energy Losses In A Variable Capacity Displacement Pump Determined Without Or With Taking Into Account The Power Of Hydraulic Oil Compression

    Directory of Open Access Journals (Sweden)

    Paszota Zygmunt

    2015-04-01

    Full Text Available Powers of energy losses in a variable capacity displacement pump are compared with or without taking into account the power of hydraulic oil compression. Evaluation of power of liquid compression in the pump was made possible by the use of method, proposed by the Author, of determining the degree of liquid aeration in the pump. In the method of determining the liquid aeration in the pump and of powers of volumetric losses of liquid compression a simplified formula (qPvc × ΔpPi/2 was used describing the field of indicated work of volumetric losses qPvc of liquid compression during one shaft revolution at indicated increase ΔpPi of pressure in the chambers. Three methods were used for comparing the sum of powers of volumetric losses ΔPPvl due to leakage and ΔPPvc of compression and also ΔPPm|ΔpPi of mechanical losses resulting from increase ΔpPi of indicated pressure in the working chambers.

  17. Patient preferences and satisfaction in a multispecialty infusion center

    Directory of Open Access Journals (Sweden)

    Ostrov BE

    2014-05-01

    Full Text Available Barbara E Ostrov,1 Kristine Reynolds,2 Lisabeth V Scalzi11Departments of Pediatrics and Medicine, 2Department of Nursing, Penn State Hershey Medical Center, Hershey, PA, USAPurpose: Direct feedback from patients about their preferred modes of medication ­administration has been increasingly sought by providers to develop care programs that best match patient goals. Multispecialty infusion centers generally provide care to hematology–oncology (HO and non-HO patients in one unit, with the same nursing staff. Our staff perceived that this was dissatisfying to our non-HO patients. We assessed patient satisfaction, as well as nursing and physician perceptions of patient preference/satisfaction with our infusion center, to determine whether a separate unit should be recommended when designing our new Cancer Institute Infusion Center.Patients and methods: A seven-question Likert scale satisfaction survey for patients, and a separate survey to assess nurses’ and physicians’ perception of patient satisfaction, were developed. The survey was administered to non-HO patients receiving infusions, doctors prescribing infusions, and nurses administering infusions. Results of the survey were compared between groups to assess differences in responses.Results: Responses were received from 52 non-HO patients, 18 physicians, and 13 nurses. Patients had more satisfaction, on all survey items, with the multispecialty infusion center than had been realized by physicians and nurses. Analysis demonstrated that patients were satisfied with care in a multispecialty infusion unit and were in favor of continuing their care in this combined center. Total scores of patient surveys were significantly different (P<0.001 from those of physicians and nurses, who had assumed patients would prefer to have their care in a non-HO infusion setting.Conclusion: Understanding patient preferences is an important step in deciding the structure of infusion centers. Based on these

  18. [First contact with an insulin pump. Clinical case].

    Science.gov (United States)

    Gutiérrez-Torre, Elena; Alconero-Camarero, Ana Rosa; Torres-Manrique, Blanca; Rodríguez-Martín, Elías

    2011-01-01

    Insulin pumps are devices that inject insulin continuously into the body in a similar way to the pancreatic secretion, and with endless possibilities to adjust schedules, meals and physical activities, giving diabetics the chance to lead a life with many less restraints due to their illness. Besides giving them this freedom, the therapy allows more precise control of blood glucose, significantly improving the overall self-control and thus the quality of life of the diabetics, reducing the appearance of long-term complications. Although all diabetics receive many guidelines and recommendations for optimal control throughout their illness patients included in this protocol must be especially aware and involved in self-control, since the treatment demands more involvement both when learning to use the device as well as making decisions once they are using it. We present the case of a type 1 diabetic patient, twenty-one years of onset, who while admitted to hospital for a day, had a continuous subcutaneous insulin infusion pump implanted (insulin pump). To this end, we developed a patient care plan of patient following the steps of scientific method and relying on the NANDA taxonomy and on the NOC and NIC to design goals and nursing interventions, respectively.

  19. Pumps in wearable ultrafiltration devices: pumps in wuf devices.

    Science.gov (United States)

    Armignacco, Paolo; Garzotto, Francesco; Bellini, Corrado; Neri, Mauro; Lorenzin, Anna; Sartori, Marco; Ronco, Claudio

    2015-01-01

    The wearable artificial kidney (WAK) is a device that is supposed to operate like a real kidney, which permits prolonged, frequent, and continuous dialysis treatments for patients with end-stage renal disease (ESRD). Its functioning is mainly related to its pumping system, as well as to its dialysate-generating and alarm/shutoff ones. A pump is defined as a device that moves fluids by mechanical action. In such a context, blood pumps pull blood from the access side of the dialysis catheter and return the blood at the same rate of flow. The main aim of this paper is to review the current literature on blood pumps, describing the way they have been functioning thus far and how they are being engineered, giving details about the most important parameters that define their quality, thus allowing the production of a radar comparative graph, and listing ideal pumps' features.

  20. Research on Power Recycling Test Method of Integrative Hydraulic Pump and Motor%联体泵马达功率回收试验方法研究

    Institute of Scientific and Technical Information of China (English)

    郭刘洋; 刘俊; 唐守生; 郭杨浏

    2013-01-01

    The experimental method for the integrative hydraulic pump and motor was researched. The power recycling theory of hydraulic pump was analyzed. According to character of the integrative hydraulic pump and motor,the test method for the integrative hydraulic pump and motor power recycling was defined. The formula to calculate volumetric efficiency was deduced. The power recycling test result is assist to analyze volumetric efficiency,meanwhile,to verify the fundamental performance of the integrative hydraulic pump and motor. Additionally,the test result proves that the integrative hydraulic pump and motor power recycling test method is feasible.%  针对联体泵马达的试验方法进行研究,分析液压泵的功率回收试验原理,根据联体泵马达的结构特点,确定了联体泵马达功率回收试验方法,并推导出容积效率计算公式;通过功率回收试验,对联体泵马达的容积效率进行了测试,验证了泵马达的基本性能,也证实了功率回收方法的有效性和可行性。

  1. Rata-rata Lama Hari Pemasangan Infus dalam Terjadinya Flebitis pada Pasien yang Dipasang Infus di RSUP Haji Adam Malik Medan

    OpenAIRE

    Mardiah, Lia

    2012-01-01

    Lama hari pemasangan infus pada pasien yang dipasang infus memiliki resiko tinggi terjadi flebitis dan kejadiannya tergantung pada kondisi kesehatan secara keseluruhan dan lamanya pemasangan infus. Penelitian ini bertujuan untuk mendapatkan rata-rata lama hari pemasangan infus dalam terjadinya flebitis pada pasien yang dipasang infus di RSUP Haji Adam Malik Medan. Penelitian ini menggunakan desain deskriptif dengan jumlah sampel sebanyak 60 orang responden yang diambil dengan teknik purpos...

  2. Parents' experiences of managing their child's diabetes using an insulin pump: a qualitative study.

    Science.gov (United States)

    Rankin, D; Harden, J; Noyes, K; Waugh, N; Barnard, K; Lawton, J

    2015-05-01

    Continuous subcutaneous insulin infusion delivered via a pump is increasingly recommended for younger children with Type 1 diabetes. Our aims were: to understand the impact on parents who care for young children using insulin pumps; to help interpret psychological outcomes reported in quantitative research; and to inform provision of support to future parents. We conducted in-depth interviews with 19 parents of children (aged ≤ 12 years) with Type 1 diabetes who used an insulin pump. Data were analysed thematically. Parents reported multiple benefits from using insulin pumps, including: no longer having to administer painful injections; fewer restrictions on the frequency, timing and carbohydrate contents of snacks and meals; and improvements in family life and their child's glycaemic control. Parents liked and felt less anxious about using bolus calculators to determine insulin doses; however, parents also described undertaking additional and unanticipated work to manage their child's diabetes using a pump. This included performing more blood glucose tests to calculate insulin doses for snacks and to address their concerns that the pump increased their child's risk of hypoglycaemia. Some parents reported doing additional blood glucose checks because they could adjust pump settings to better manage hypo- and hyperglycaemia. Parents liked and perceived benefits for their child and themselves from using an insulin pump; however, parents would benefit from being made aware of the additional work involved in using a pump and also from education and support to address concerns about hypoglycaemia. Better measures to evaluate parents' experiences are also recommended. © 2015 The Authors. Diabetic Medicine © 2015 Diabetes UK.

  3. Intraarterial infusion chemotherapy for the treatment of metastatic liver cancer

    Energy Technology Data Exchange (ETDEWEB)

    Arai, Yasuaki; Kido, Choichiro

    1987-12-01

    Some techniques of the most recent interventional radiology are very useful for the treatment of metastatic liver cancer and changing the style of hepatic infusion chemotherapy. This report shows our latest results and methods of hepatic infusion chemotherapy for metastatic liver cancer. 1. For the catheter placement, a new catheterization route via the left subclavian artery into the hepatic artery was developed and performed in 132 cases. Superselective catheterization succeeded in 123 cases (93.2%). This procedure is less invasive than laparotomy and less troublesome than other percutaneous routes. 2. For useful infusion system, an implantable injection port ''Reservoir'' was developed and it was used in 87 cases. This method makes arterial infusion chemotherapy easy, and imploves their quality of life. 3. To acquire adequate drug delivery, arterial redistribution by steel coils was done, and 109 arteries in 80 cases were occluded. This method is very useful to make multiple hepatic artery single and it is important to avoid gasroduodenal complications. 4. Now, using these techniques, the phase II study of 5FU, ADM, MMC combined hepatic infusion in patients with non-resectable metastatic liver cancer is done. Up to this time, such a phase study on arterial infusion chemotherapy was difficult because of technical problems, but these new techniques make it possible. In conclusion, these new methods change the style and conception of hepatic infusion, and these make much progress on the treatment of patients with metastatic liver cancer.

  4. Constant-Pressure Hydraulic Pump

    Science.gov (United States)

    Galloway, C. W.

    1982-01-01

    Constant output pressure in gas-driven hydraulic pump would be assured in new design for gas-to-hydraulic power converter. With a force-multiplying ring attached to gas piston, expanding gas would apply constant force on hydraulic piston even though gas pressure drops. As a result, pressure of hydraulic fluid remains steady, and power output of the pump does not vary.

  5. [Treatment by external insulin pump].

    Science.gov (United States)

    Clavel, Sylvaine

    2010-12-01

    Since the recent recommendations by the French speaking association for research on diabetes and metabolic illnesses (Alfediam), treatment by insulin pump has found itself in competition with basal-bolus, a procedure using similar injections of insulin which has become a benchmark treatment. The latest Alfediam guidelines focus on defining ways of treating diabetics with an external insulin pump.

  6. High Temperature Thermoacoustic Heat Pump

    Energy Technology Data Exchange (ETDEWEB)

    Tijani, H.; Spoelstra, S. [ECN Biomass and Energy Efficiency, Petten (Netherlands)

    2012-07-15

    Thermoacoustic technology can provide new types of heat pumps that can be deployed in different applications. Thermoacoustic heat pumps can for example be applied in dwellings to generate cooling or heating. Typically, space and water heating makes up about 60% of domestic and office energy consumption. The application of heat pumps can contribute to achieve energy savings and environmental benefits by reducing CO2 and NOx emissions. This paper presents the study of a laboratory scale thermoacoustic-Stirling heat pump operating between 10C and 80C which can be applied in domestics and offices. The heat pump is driven by a thermoacoustic-Stirling engine. The experimental results show that the heat pump pumps 250 W of heat at 60C at a drive ratio of 3.6 % and 200 W at 80C at a drive ratio of 3.5 %. The performance for both cases is about 40% of the Carnot performance. The design, construction, and performance measurements of the heat pump will be presented and discussed.

  7. Ion-Pumping Microbial Rhodopsins

    Directory of Open Access Journals (Sweden)

    Hideki eKandori

    2015-09-01

    Full Text Available Rhodopsins are light-sensing proteins used in optogenetics. The word rhodopsin originates from the Greek words rhodo and opsis, indicating rose and sight, respectively. Although the classical meaning of rhodopsin is the red-colored pigment in our eyes, the modern meaning of rhodopsin encompasses photoactive proteins containing a retinal chromophore in animals and microbes. Animal and microbial rhodopsins possess 11-cis and all-trans retinal, respectively, to capture light in seven transmembrane α-helices, and photoisomerizations into all-trans and 13-cis forms, respectively, initiate each function. Ion-transporting proteins can be found in microbial rhodopsins, such as light-gated channels and light-driven pumps, which are the main tools in optogenetics. Light-driven pumps, such as archaeal H+ pump bacteriorhodopsin (BR and Cl- pump halorhodopsin (HR, were discovered in the 1970s, and their mechanism has been extensively studied. On the other hand, different kinds of H+ and Cl- pumps have been found in marine bacteria, such as proteorhodopsin (PR and Fulvimarina pelagi rhodopsin (FR, respectively. In addition, a light-driven Na+ pump was found, Krokinobacter eikastus rhodopsin 2 (KR2. These light-driven ion-pumping microbial rhodopsins are classified as DTD, TSA, DTE, NTQ and NDQ rhodopsins for BR, HR, PR, FR and KR2, respectively. Recent understanding of ion-pumping microbial rhodopsins is reviewed in this paper.

  8. Rapid mapping of volumetric machine errors using distance measurements

    Energy Technology Data Exchange (ETDEWEB)

    Krulewich, D.A.

    1998-04-01

    This paper describes a relatively inexpensive, fast, and easy to execute approach to maping the volumetric errors of a machine tool, coordinate measuring machine, or robot. An error map is used to characterize a machine or to improve its accuracy by compensating for the systematic errors. The method consists of three steps: (1) models the relationship between volumetric error and the current state of the machine, (2) acquiring error data based on distance measurements throughout the work volume; and (3)fitting the error model using the nonlinear equation for the distance. The error model is formulated from the kinematic relationship among the six degrees of freedom of error an each moving axis. Expressing each parametric error as function of position each is combined to predict the error between the functional point and workpiece, also as a function of position. A series of distances between several fixed base locations and various functional points in the work volume is measured using a Laser Ball Bar (LBB). Each measured distance is a non-linear function dependent on the commanded location of the machine, the machine error, and the location of the base locations. Using the error model, the non-linear equation is solved producing a fit for the error model Also note that, given approximate distances between each pair of base locations, the exact base locations in the machine coordinate system determined during the non-linear filling procedure. Furthermore, with the use of 2048 more than three base locations, bias error in the measuring instrument can be removed The volumetric errors of three-axis commercial machining center have been mapped using this procedure. In this study, only errors associated with the nominal position of the machine were considered Other errors such as thermally induced and load induced errors were not considered although the mathematical model has the ability to account for these errors. Due to the proprietary nature of the projects we are

  9. Blood doping : infusions, erythropoietin and artificial blood.

    Science.gov (United States)

    Eichner, E Randy

    2007-01-01

    As science marches on, athletes and coaches march close behind. Researchers have long been interested in how red cell mass and blood volume affect exercise capacity. Interest in blood doping soared after the 1968 Mexico City Olympics. Studies in the 1970s and 1980s suggested that transfusing red cells could speed endurance performance. Diverse athletes of the time were accused of blood doping. In the late 1980s, recombinant human erythropoietin (EPO) began to supplant transfusion for doping. EPO use is a suspect in nearly 20 deaths in 4 years in European cyclists. In the 1998 Tour de France, a team was ejected for using EPO and six other teams quit the race. The beat goes on; in recent years, diverse endurance and sprint athletes have been caught or accused of using EPO. Tests to detect EPO are improving but are not yet foolproof. As EPO tests improve, blood transfusion is back in vogue and some athletes may have infused artificial blood. Tests for detecting artificial blood also exist, but it seems it will take widespread, year-round, unannounced, out-of-competition testing and stern penalties to deter blood doping.

  10. Evaluation of a balloon constant rate infusion system for treatment of septic arthritis, septic tenosynovitis, and contaminated synovial wounds: 23 cases (2002-2005).

    Science.gov (United States)

    Meagher, Daniel T; Latimer, Federico G; Sutter, W Wes; Saville, William J A

    2006-06-15

    OBJECTIVE-To determine clinical findings and outcome in horses treated by means of a balloon constant rate infusion system. DESIGN-Retrospective case series. ANIMALS-23 horses. PROCEDURES-Medical records of horses examined at The Ohio State University veterinary teaching hospital from 2002 to 2005 that had septic arthritis, septic tenosynovitis, or penetration of a synovial structure and in which treatment involved a balloon constant rate infusion system were searched. Information pertaining to signalment, history, physical examination findings, clinicopathologic data, treatment, and duration of hospitalization was recorded. RESULTS-Mean+/- SD duration of hospitalization was 11.5+/-5.26 days. No correlation between duration of clinical signs and duration of hospitalization or duration of infusion pump use was detected, but correlations between WBC count and duration of hospitalization and WBC and duration of infusion-pump use were observed. All horses survived to discharge. Follow-up information was obtained on 17 horses, 16 of which were alive at the time of follow-up. Twelve of 13 horses for which followup information was available for at least 5 months were alive 5 months or longer after discharge. Thirteen of the 16 horses alive at follow-up were reported by owners as not lame, whereas the remaining 3 were mildly lame or intermittently moderately lame or had developed angular limb deformity in the contralateral limb. CONCLUSIONS AND CLINICAL RELEVANCE-Balloon constant rate infusion systems may be used effectively in treatment of septic arthritis, septic tenosynovitis, and contaminated synovial wounds. Clinical response and long-term outcome appeared to be comparable to results obtained with other techniques.

  11. Insulin pump therapy in pregnancy.

    Science.gov (United States)

    Kesavadev, Jothydev

    2016-09-01

    Control of blood glucose during pregnancy is difficult because of wide variations, ongoing hormonal changes and mood swings. The need for multiple injections, pain at the injection site, regular monitoring and skillful handling of the syringes/pen further makes insulin therapy inconvenient. Insulin pump is gaining popularity in pregnancy because it mimics the insulin delivery of a healthy human pancreas. Multiple guidelines have also recommended the use of insulin pump in pregnancy to maintain the glycaemic control. The pump can release small doses of insulin continuously (basal), or a bolus dose close to mealtime to control the spike in blood glucose after a meal and the newer devices can shut down insulin delivery before the occurrence of hypoglycaemia. Pump insulin of choice is rapid acting analogue insulin. This review underscores the role of insulin pump in pregnancy, their usage, advantages and disadvantages in the light of existing literature and clinic experience.

  12. A data pump for communication

    Science.gov (United States)

    Kang, Myong H.; Moskowitz, Ira S.

    1995-09-01

    As computer systems become more open and interconnected, the need for reliable and secure communication also increases. In this paper, we introduce a communication device, the Pump, that balances the requirements of reliability and security. The Pump provides acknowledgements (ACK's) to the message source to insure reliability. These ACK's are also used to regulate the source to prevent the Pump's buffer from becoming/staying full. This is desirable because once the buffer is filled there exists a huge covert communication channel. The Pump controls the input rate from the source by attempting to slave the input rate to the service rate through the randomized ACK back to the source. An analysis of the covert channel is also presented. The purpose of the covert channel analysis is to provide guidelines for the designer of the Pump to choose appropriate design parameters (e.g., size of buffer) dependent upon the analysis presented in this paper and system requirements.

  13. Peltier heat pumps. Peltiervaermepumpar

    Energy Technology Data Exchange (ETDEWEB)

    Torstensson, H. (Studsvik Energy, Nykoeping (SE))

    1990-06-01

    Todays Peltier devices in heat pump applications gives a low coeffificent of performance. A temperature difference of 40 deg C results in a COP-value of approx. 1.3. Peltier devices are manufactured of alloys composed of heavy elements like tellurium, selenium, bismuth and antimony. These elements thermoelectrical properties, figure of merit are decisive to the performance of the Peltier devices. An upper limit for the figure of merit, ZT, is said to be 2, which at {Delta}T=40 deg C would yield a COP of 2.0 as a maximum. Organic compounds have been investigated with regard to the electric conductivity. Thin film technique have been used for Peltier devices in micro-scale. There are no large-scale applications. The method does not give enhanced termoelectrical properties, but more rational and cheaper manufacturing. (author) (47 refs., 26 figs.).

  14. Self pumping magnetic cooling

    Science.gov (United States)

    Chaudhary, V.; Wang, Z.; Ray, A.; Sridhar, I.; Ramanujan, R. V.

    2017-01-01

    Efficient thermal management and heat recovery devices are of high technological significance for innovative energy conservation solutions. We describe a study of a self-pumping magnetic cooling device, which does not require external energy input, employing Mn-Zn ferrite nanoparticles suspended in water. The device performance depends strongly on magnetic field strength, nanoparticle content in the fluid and heat load temperature. Cooling (ΔT) by ~20 °C and ~28 °C was achieved by the application of 0.3 T magnetic field when the initial temperature of the heat load was 64 °C and 87 °C, respectively. These experiments results were in good agreement with simulations performed with COMSOL Multiphysics. Our system is a self-regulating device; as the heat load increases, the magnetization of the ferrofluid decreases; leading to an increase in the fluid velocity and consequently, faster heat transfer from the heat source to the heat sink.

  15. PLT rotating pumped limiter

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, S.A.; Budny, R.V.; Corso, V.; Boychuck, J.; Grisham, L.; Heifetz, D.; Hosea, J.; Luyber, S.; Loprest, P.; Manos, D.

    1984-07-01

    A limiter with a specially contoured front face and the ability to rotate during tokamak discharges has been installed in a PLT pump duct. These features have been selected to handle the unique particle removal and heat load requirements of ICRF heating and lower-hybrid current-drive experiments. The limiter has been conditioned and commissioned in an ion-beam test stand by irradiation with 1 MW power, 200 ms duration beams of 40 keV hydrogen ions. Operation in PLT during ohmic discharges has proven the ability of the limiter to reduce localized heating caused by energetic electron bombardment and to remove about 2% of the ions lost to the PLT walls and limiters.

  16. Electric fluid pump

    Science.gov (United States)

    Van Dam, Jeremy Daniel; Turnquist, Norman Arnold; Raminosoa, Tsarafidy; Shah, Manoj Ramprasad; Shen, Xiaochun

    2015-09-29

    An electric machine is presented. The electric machine includes a hollow rotor; and a stator disposed within the hollow rotor, the stator defining a flow channel. The hollow rotor includes a first end portion defining a fluid inlet, a second end portion defining a fluid outlet; the fluid inlet, the fluid outlet, and the flow channel of the stator being configured to allow passage of a fluid from the fluid inlet to the fluid outlet via the flow channel; and wherein the hollow rotor is characterized by a largest cross-sectional area of hollow rotor, and wherein the flow channel is characterized by a smallest cross-sectional area of the flow channel, wherein the smallest cross-sectional area of the flow channel is at least about 25% of the largest cross-sectional area of the hollow rotor. An electric fluid pump and a power generation system are also presented.

  17. Heat pumps in industry. Pt. 2: Applications

    Energy Technology Data Exchange (ETDEWEB)

    Lazzarin, R.M. [Padova Univ., Vicenza (Italy). Ist. di Ingegneria Gestionale

    1995-04-01

    A selection of applications of heat pumps in industry is described, reporting plant lay-outs and performances. The selection includes compression heat pumps at different temperatures, vapour recompression systems, absorption heat pumps and heat transformers. (author)

  18. The effect of a subcutaneous infusion of GLP-1, OXM and PYY on Energy intake and Expenditure in Obese volunteers

    DEFF Research Database (Denmark)

    Tan, Tricia; Behary, Preeshila; Tharakan, George

    2017-01-01

    Background: Roux-en-Y gastric bypass (RYGB) surgery is currently the most effective treatment for obesity, although limited by availability and operative risk. The gut hormones Glucagon-like peptide-1 (GLP-1), Peptide YY (PYY) and Oxyntomodulin (OXM) are elevated post-prandially after RYGB, which......-prandial levels observed after RYGB, is shown to be safe and effective in reducing food intake. This data suggests that triple hormone therapy might be a useful tool against obesity....... the effect of a continuous infusion of GLP-1, OXM and PYY (GOP) on energy intake and expenditure in obese volunteers. Methods: Obese volunteers were randomised to receive an infusion of GOP or placebo in a single-blinded randomised placebo-controlled cross-over study for 10.5 hours a day. This was delivered...... subcutaneously using a pump device, allowing volunteers to remain ambulatory. Ad Libitum food intake studies were performed during the infusion and energy expenditure measured using a ventilated hood calorimeter. Results: Post-prandial levels of GLP-1, OXM and PYY seen post RYGB were successfully matched using 4...

  19. Energy and exergy analysis of heat pump using R744/R32 refrigerant mixture

    Directory of Open Access Journals (Sweden)

    Wang Fang

    2014-01-01

    Full Text Available An energy and exergy analysis of heat pump with blends of refrigerant mixture R744/R32 was carried out. The coefficient of performance and exergy efficiency of the system were studied with different mass fraction of R744 in the blends and different heat source temperatures. The volumetric heat capacity, condensing pressure, discharge temperature, and compression ratio were also investigated. The results indicate that at a certain concentration (15/85 by mass, the blends achieve better performance, and are superior to those of R22, the results also show that the new refrigerant mixture is an attractive option for promising alternative refrigerant.

  20. Counter-current chromatography of black tea infusions.

    Science.gov (United States)

    Wedzicha, B L; Lo, M F; Donovan, T J

    1990-05-04

    Counter-current chromatography using a multilayer coil planet centrifuge, with solvent system ethyl acetate-butanol-water, permits the separation of black tea infusions into fractions which include pure SII and a mixture of SI and SIa thearubigins. Good resolution of several components of the infusion may be achieved in elution times of 1 to 2 h. The appearance of chromatograms is altered on decaffeinating the infusion. The effect of stationary phase composition is considered. Resolution of the peaks improves with butanol content.

  1. Severe infusion reaction induced by trastuzumab: a case report.

    Science.gov (United States)

    Tada, Keiichiro; Ito, Yoshinori; Hatake, Kiyohiko; Okudaira, Taeko; Watanabe, Jun-ichiro; Arakawa, Masahiro; Miyazato, Masayo; Irie, Tetsuya; Mizunuma, Nobuyuki; Takahashi, Syunji; Aiba, Keisuke; Horikoshi, Noboru; Kasumi, Fujio

    2003-01-01

    We report a case of a severe infusion reaction caused by trastuzumab. A 59-year-old woman with metastatic breast cancer was treated with trastuzumab. During the first infusion, initial symptoms such as severe headache and general fatigue developed. Blood pressure fell 90 minutes after these initial symptoms. A collapsed lung was demonstrated by chest X-ray and computed tomography. Steroid therapy was successfully used for these reactions. Careful monitoring of vital signs, examination of the respiratory system, and the use of steroids are recommended for severe infusion reaction.

  2. Automatic Control of Water Pumping Stations

    Institute of Scientific and Technical Information of China (English)

    Muhannad Alrheeh; JIANG Zhengfeng

    2006-01-01

    Automatic Control of pumps is an interesting proposal to operate water pumping stations among many kinds of water pumping stations according to their functions.In this paper, our pumping station is being used for water supply system. This paper is to introduce the idea of pump controller and the important factors that must be considering when we want to design automatic control system of water pumping stations. Then the automatic control circuit with the function of all components will be introduced.

  3. Quantitative volumetric Raman imaging of three dimensional cell cultures

    Science.gov (United States)

    Kallepitis, Charalambos; Bergholt, Mads S.; Mazo, Manuel M.; Leonardo, Vincent; Skaalure, Stacey C.; Maynard, Stephanie A.; Stevens, Molly M.

    2017-03-01

    The ability to simultaneously image multiple biomolecules in biologically relevant three-dimensional (3D) cell culture environments would contribute greatly to the understanding of complex cellular mechanisms and cell-material interactions. Here, we present a computational framework for label-free quantitative volumetric Raman imaging (qVRI). We apply qVRI to a selection of biological systems: human pluripotent stem cells with their cardiac derivatives, monocytes and monocyte-derived macrophages in conventional cell culture systems and mesenchymal stem cells inside biomimetic hydrogels that supplied a 3D cell culture environment. We demonstrate visualization and quantification of fine details in cell shape, cytoplasm, nucleus, lipid bodies and cytoskeletal structures in 3D with unprecedented biomolecular specificity for vibrational microspectroscopy.

  4. Optimization approaches to volumetric modulated arc therapy planning

    Energy Technology Data Exchange (ETDEWEB)

    Unkelbach, Jan, E-mail: junkelbach@mgh.harvard.edu; Bortfeld, Thomas; Craft, David [Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 (United States); Alber, Markus [Department of Medical Physics and Department of Radiation Oncology, Aarhus University Hospital, Aarhus C DK-8000 (Denmark); Bangert, Mark [Department of Medical Physics in Radiation Oncology, German Cancer Research Center, Heidelberg D-69120 (Germany); Bokrantz, Rasmus [RaySearch Laboratories, Stockholm SE-111 34 (Sweden); Chen, Danny [Department of Computer Science and Engineering, University of Notre Dame, Notre Dame, Indiana 46556 (United States); Li, Ruijiang; Xing, Lei [Department of Radiation Oncology, Stanford University, Stanford, California 94305 (United States); Men, Chunhua [Department of Research, Elekta, Maryland Heights, Missouri 63043 (United States); Nill, Simeon [Joint Department of Physics at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London SM2 5NG (United Kingdom); Papp, Dávid [Department of Mathematics, North Carolina State University, Raleigh, North Carolina 27695 (United States); Romeijn, Edwin [H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 (United States); Salari, Ehsan [Department of Industrial and Manufacturing Engineering, Wichita State University, Wichita, Kansas 67260 (United States)

    2015-03-15

    Volumetric modulated arc therapy (VMAT) has found widespread clinical application in recent years. A large number of treatment planning studies have evaluated the potential for VMAT for different disease sites based on the currently available commercial implementations of VMAT planning. In contrast, literature on the underlying mathematical optimization methods used in treatment planning is scarce. VMAT planning represents a challenging large scale optimization problem. In contrast to fluence map optimization in intensity-modulated radiotherapy planning for static beams, VMAT planning represents a nonconvex optimization problem. In this paper, the authors review the state-of-the-art in VMAT planning from an algorithmic perspective. Different approaches to VMAT optimization, including arc sequencing methods, extensions of direct aperture optimization, and direct optimization of leaf trajectories are reviewed. Their advantages and limitations are outlined and recommendations for improvements are discussed.

  5. Volumetric properties of water/AOT/isooctane microemulsions.

    Science.gov (United States)

    Du, Changfei; He, Wei; Yin, Tianxiang; Shen, Weiguo

    2014-12-23

    The densities of AOT/isooctane micelles and water/AOT/isooctane microemulsions with the molar ratios R of water to AOT being 2, 8, 10, 12, 16, 18, 20, 25, 30, and 40 were measured at 303.15 K. The apparent specific volumes of AOT and the quasi-component water/AOT at various concentrations were calculated and used to estimate the volumetric properties of AOT and water in the droplets and in the continuous oil phase, to discuss the interaction between the droplets, and to determine the critical micelle concentration and the critical microemulsion concentrations. A thermodynamic model was proposed to analysis the stability boundary of the microemulsion droplets, which confirms the maximum value of R being about 65 for the stable AOT/water/isooctane microemulsion droplets.

  6. Quantitative volumetric Raman imaging of three dimensional cell cultures

    KAUST Repository

    Kallepitis, Charalambos

    2017-03-22

    The ability to simultaneously image multiple biomolecules in biologically relevant three-dimensional (3D) cell culture environments would contribute greatly to the understanding of complex cellular mechanisms and cell–material interactions. Here, we present a computational framework for label-free quantitative volumetric Raman imaging (qVRI). We apply qVRI to a selection of biological systems: human pluripotent stem cells with their cardiac derivatives, monocytes and monocyte-derived macrophages in conventional cell culture systems and mesenchymal stem cells inside biomimetic hydrogels that supplied a 3D cell culture environment. We demonstrate visualization and quantification of fine details in cell shape, cytoplasm, nucleus, lipid bodies and cytoskeletal structures in 3D with unprecedented biomolecular specificity for vibrational microspectroscopy.

  7. In-line hologram segmentation for volumetric samples.

    Science.gov (United States)

    Orzó, László; Göröcs, Zoltán; Fehér, András; Tőkés, Szabolcs

    2013-01-01

    We propose a fast, noniterative method to segment an in-line hologram of a volumetric sample into in-line subholograms according to its constituent objects. In contrast to the phase retrieval or twin image elimination algorithms, we do not aim or require to reconstruct the complex wave field of all the objects, which would be a more complex task, but only provide a good estimate about the contribution of the particular objects to the original hologram quickly. The introduced hologram segmentation algorithm exploits the special inner structure of the in-line holograms and applies only the estimated supports and reconstruction distances of the corresponding objects as parameters. The performance of the proposed method is demonstrated and analyzed experimentally both on synthetic and measured holograms. We discussed how the proposed algorithm can be efficiently applied for object reconstruction and phase retrieval tasks.

  8. Three-Dimensional Volumetric Restoration by Structural Fat Grafting

    Science.gov (United States)

    Clauser, Luigi C.; Consorti, Giuseppe; Elia, Giovanni; Galié, Manlio; Tieghi, Riccardo

    2013-01-01

    The use of adipose tissue transfer for correction of maxillofacial defects was reported for the first time at the end of the 19th century. Structural fat grafting (SFG) was introduced as a way to improve facial esthetics and in recent years has evolved into applications in craniomaxillofacial reconstructive surgery. Several techniques have been proposed for harvesting and grafting the fat. However, owing to the damage of many adipocytes during these maneuvers, the results have not been satisfactory and have required several fat injection procedures for small corrections. The author's (L.C.) overview the application of SFG in the management of volumetric deficit in the craniomaxillofacial in patients treated with a long-term follow-up. PMID:24624259

  9. Semi-automatic volumetrics system to parcellate ROI on neocortex

    Science.gov (United States)

    Tan, Ou; Ichimiya, Tetsuya; Yasuno, Fumihiko; Suhara, Tetsuya

    2002-05-01

    A template-based and semi-automatic volumetrics system--BrainVol is build to divide the any given patient brain to neo-cortical and sub-cortical regions. The standard region is given as standard ROI drawn on a standard brain volume. After normalization between the standard MR image and the patient MR image, the sub-cortical ROIs' boundary are refined based on gray matter. The neo-cortical ROIs are refined by sulcus information that is semi-automatically marked on the patient brain. Then the segmentation is applied to 4D PET image of same patient for calculation of TAC (Time Activity Curve) by co-registration between MR and PET.

  10. Out-of-core clustering of volumetric datasets

    Institute of Scientific and Technical Information of China (English)

    GRANBERG Carl J.; LI Ling

    2006-01-01

    In this paper we present a novel method for dividing and clustering large volumetric scalar out-of-core datasets. This work is based on the Ordered Cluster Binary Tree (OCBT) structure created using a top-down or divisive clustering method. The OCBT structure allows fast and efficient sub volume queries to be made in combination with level of detail (LOD) queries of the tree. The initial partitioning of the large out-of-core dataset is done by using non-axis aligned planes calculated using Principal Component Analysis (PCA). A hybrid OCBT structure is also proposed where an in-core cluster binary tree is combined with a large out-of-core file.

  11. Volumetric Survey Speed: A Figure of Merit for Transient Surveys

    CERN Document Server

    Bellm, Eric C

    2016-01-01

    Time-domain surveys can exchange sky coverage for revisit frequency, complicating the comparison of their relative capabilities. By using different revisit intervals, a specific camera may execute surveys optimized for discovery of different classes of transient objects. We propose a new figure of merit, the instantaneous volumetric survey speed, for evaluating transient surveys. This metric defines the trade between cadence interval and snapshot survey volume and so provides a natural means of comparing survey capability. The related metric of areal survey speed imposes a constraint on the range of possible revisit times: we show that many modern time-domain surveys are limited by the amount of fresh sky available each night. We introduce the concept of "spectroscopic accessibility" and discuss its importance for transient science goals requiring followup observing. We present an extension of the control time algorithm for cases where multiple consecutive detections are required. Finally, we explore how surv...

  12. Accuracy of a new patch pump based on a microelectromechanical system (MEMS) compared to other commercially available insulin pumps: results of the first in vitro and in vivo studies.

    Science.gov (United States)

    Borot, Sophie; Franc, Sylvia; Cristante, Justine; Penfornis, Alfred; Benhamou, Pierre-Yves; Guerci, Bruno; Hanaire, Hélène; Renard, Eric; Reznik, Yves; Simon, Chantal; Charpentier, Guillaume

    2014-11-01

    The JewelPUMP™ (JP) is a new patch pump based on a microelectromechanical system that operates without any plunger. The study aimed to evaluate the infusion accuracy of the JP in vitro and in vivo. For the in vitro studies, commercially available pumps meeting the ISO standard were compared to the JP: the MiniMed® Paradigm® 712 (MP), Accu-Chek® Combo (AC), OmniPod® (OP), Animas® Vibe™ (AN). Pump accuracy was measured over 24 hours using a continuous microweighing method, at 0.1 and 1 IU/h basal rates. The occlusion alarm threshold was measured after a catheter occlusion. The JP, filled with physiological serum, was then tested in 13 patients with type 1 diabetes simultaneously with their own pump for 2 days. The weight difference was used to calculate the infused insulin volume. The JP showed reduced absolute median error rate in vitro over a 15-minute observation window compared to other pumps (1 IU/h): ±1.02% (JP) vs ±1.60% (AN), ±1.66% (AC), ±2.22% (MP), and ±4.63% (OP), P pumps: 21 (19; 25) minutes vs 90 (85; 95), 58 (42; 74), and 143 (132; 218) minutes (AN, AC, MP), P pumps (-2.2 ± 5.6% vs -0.37 ± 4.0%, P = .25). The JP was found to be easier to wear than conventional pumps. The JP is more precise over a short time period, more sensitive to catheter occlusion, well accepted by patients, and consequently, of potential interest for a closed-loop insulin delivery system.

  13. Field comparison of Bermuda-hay infusion to infusions of emergent aquatic vegetation for collecting female mosquitoes.

    Science.gov (United States)

    Burkett-Cadena, Nathan D; Mullen, Gary R

    2007-06-01

    Field experiments were conducted in east-central Alabama in 2003 and 2004 to compare the attractiveness of selected gravid-trap infusions to ovipositing female mosquitoes. Comparisons were made among infusions of the following plants: Bermuda hay, Cynodon dactylon, and 3 species of emergent aquatic plants typical of Culex larval habitats, i.e., soft rush, Juncus effusus; a common sedge, Rhynchospora corniculata; and broad-leaf cattail, Typha latifolia. Experiments were conducted at a site in Lee County, AL, with an abundance of common nuisance mosquitoes, including Culex quinquefasciatus and Aedes albopictus. Carbon dioxide-baited miniature light traps were operated concurrently with gravid traps to provide an activity index of mosquito species at the site. Gravid traps with hay infusion collected the greatest numbers of Cx. quinquefasciatus and Culex restuans females (2003). The results indicate that hay infusion is highly attractive to Cx. quinquefasciatus and is the infusion of choice for collecting females of this species in gravid traps. In the case of Ae. albopictus, infusions were not determined to be significantly different from one another in their attractiveness to gravid females. In general, females of Cx. quinquefasciatus and Cx. restuans demonstrated selectivity when choosing an oviposition site, whereas Ae. albopictus females did not. Factors associated with the oviposition biology of the latter species most likely account for their lack of preference for any single infusion type.

  14. Volumetric optical coherence microscopy enabled by aberrated optics (Conference Presentation)

    Science.gov (United States)

    Mulligan, Jeffrey A.; Liu, Siyang; Adie, Steven G.

    2017-02-01

    Optical coherence microscopy (OCM) is an interferometric imaging technique that enables high resolution, non-invasive imaging of 3D cell cultures and biological tissues. Volumetric imaging with OCM suffers a trade-off between high transverse resolution and poor depth-of-field resulting from defocus, optical aberrations, and reduced signal collection away from the focal plane. While defocus and aberrations can be compensated with computational methods such as interferometric synthetic aperture microscopy (ISAM) or computational adaptive optics (CAO), reduced signal collection must be physically addressed through optical hardware. Axial scanning of the focus is one approach, but comes at the cost of longer acquisition times, larger datasets, and greater image reconstruction times. Given the capabilities of CAO to compensate for general phase aberrations, we present an alternative method to address the signal collection problem without axial scanning by using intentionally aberrated optical hardware. We demonstrate the use of an astigmatic spectral domain (SD-)OCM imaging system to enable single-acquisition volumetric OCM in 3D cell culture over an extended depth range, compared to a non-aberrated SD-OCM system. The transverse resolution of the non-aberrated and astigmatic imaging systems after application of CAO were 2 um and 2.2 um, respectively. The depth-range of effective signal collection about the nominal focal plane was increased from 100 um in the non-aberrated system to over 300 um in the astigmatic system, extending the range over which useful data may be acquired in a single OCM dataset. We anticipate that this method will enable high-throughput cellular-resolution imaging of dynamic biological systems over extended volumes.

  15. Marginal Space Deep Learning: Efficient Architecture for Volumetric Image Parsing.

    Science.gov (United States)

    Ghesu, Florin C; Krubasik, Edward; Georgescu, Bogdan; Singh, Vivek; Yefeng Zheng; Hornegger, Joachim; Comaniciu, Dorin

    2016-05-01

    Robust and fast solutions for anatomical object detection and segmentation support the entire clinical workflow from diagnosis, patient stratification, therapy planning, intervention and follow-up. Current state-of-the-art techniques for parsing volumetric medical image data are typically based on machine learning methods that exploit large annotated image databases. Two main challenges need to be addressed, these are the efficiency in scanning high-dimensional parametric spaces and the need for representative image features which require significant efforts of manual engineering. We propose a pipeline for object detection and segmentation in the context of volumetric image parsing, solving a two-step learning problem: anatomical pose estimation and boundary delineation. For this task we introduce Marginal Space Deep Learning (MSDL), a novel framework exploiting both the strengths of efficient object parametrization in hierarchical marginal spaces and the automated feature design of Deep Learning (DL) network architectures. In the 3D context, the application of deep learning systems is limited by the very high complexity of the parametrization. More specifically 9 parameters are necessary to describe a restricted affine transformation in 3D, resulting in a prohibitive amount of billions of scanning hypotheses. The mechanism of marginal space learning provides excellent run-time performance by learning classifiers in clustered, high-probability regions in spaces of gradually increasing dimensionality. To further increase computational efficiency and robustness, in our system we learn sparse adaptive data sampling patterns that automatically capture the structure of the input. Given the object localization, we propose a DL-based active shape model to estimate the non-rigid object boundary. Experimental results are presented on the aortic valve in ultrasound using an extensive dataset of 2891 volumes from 869 patients, showing significant improvements of up to 45

  16. The volumetric rate of superluminous supernovae at z ˜ 1

    Science.gov (United States)

    Prajs, S.; Sullivan, M.; Smith, M.; Levan, A.; Karpenka, N. V.; Edwards, T. D. P.; Walker, C. R.; Wolf, W. M.; Balland, C.; Carlberg, R.; Howell, D. A.; Lidman, C.; Pain, R.; Pritchet, C.; Ruhlmann-Kleider, V.

    2017-01-01

    We present a measurement of the volumetric rate of superluminous supernovae (SLSNe) at z ˜ 1.0, measured using archival data from the first four years of the Canada-France-Hawaii Telescope Supernova Legacy Survey (SNLS). We develop a method for the photometric classification of SLSNe to construct our sample. Our sample includes two previously spectroscopically identified objects, and a further new candidate selected using our classification technique. We use the point-source recovery efficiencies from Perrett et al. and a Monte Carlo approach to calculate the rate based on our SLSN sample. We find that the three identified SLSNe from SNLS give a rate of 91^{+76}_{-36} SNe yr-1 Gpc-3 at a volume-weighted redshift of z = 1.13. This is equivalent to 2.2^{+1.8}_{-0.9}× 10^{-4} of the volumetric core-collapse supernova rate at the same redshift. When combined with other rate measurements from the literature, we show that the rate of SLSNe increases with redshift in a manner consistent with that of the cosmic star formation history. We also estimate the rate of ultra-long gamma-ray bursts based on the events discovered by the Swift satellite, and show that it is comparable to the rate of SLSNe, providing further evidence of a possible connection between these two classes of events. We also examine the host galaxies of the SLSNe discovered in SNLS, and find them to be consistent with the stellar-mass distribution of other published samples of SLSNe.

  17. Volumetric analysis of corticocancellous bones using CT data

    Energy Technology Data Exchange (ETDEWEB)

    Krappinger, Dietmar; Linde, Astrid von; Rosenberger, Ralf; Blauth, Michael [Medical University Innsbruck, Department of Trauma Surgery and Sports Medicine, Innsbruck (Austria); Glodny, Bernhard; Niederwanger, Christian [Medical University Innsbruck, Department of Radiology I, Innsbruck (Austria)

    2012-05-15

    To present a method for an automated volumetric analysis of corticocancellous bones such as the superior pubic ramus using CT data and to assess the reliability of this method. Computed tomography scans of a consecutive series of 250 patients were analyzed. A Hounsfield unit (HU) thresholding-based reconstruction technique (''Vessel Tracking,'' GE Healthcare) was used. A contiguous space of cancellous bone with similar HU values between the starting and end points was automatically identified as the region of interest. The identification was based upon the density gradient to the adjacent cortical bone. The starting point was defined as the middle of the parasymphyseal corticocancellous transition zone on the axial slice showing the parasymphyseal superior pubic ramus in its maximum anteroposterior width. The end point was defined as the middle of the periarticular corticocancellous transition zone on the axial slice showing the quadrilateral plate as a thin cortical plate. The following parameters were automatically obtained on both sides: length of the center line, volume of the superior pubic ramus between the starting point and end point, minimum, maximum and mean diameter perpendicular to the center line, and mean cross-sectional area perpendicular to the center line. An automated analysis without manual adjustments was successful in 207 patients (82.8%). The center line showed a significantly greater length in female patients (67.6 mm vs 65.0 mm). The volume was greater in male patients (21.8 cm{sup 3} vs 19.4 cm{sup 3}). The intersite reliability was high with a mean difference between the left and right sides of between 0.1% (cross-sectional area) and 2.3% (volume). The method presented allows for an automated volumetric analysis of a corticocancellous bone using CT data. The method is intended to provide preoperative information for the use of intramedullary devices in fracture fixation and percutaneous cement augmentation techniques

  18. An Analysis Methodology for Stochastic Characteristic of Volumetric Error in Multiaxis CNC Machine Tool

    Directory of Open Access Journals (Sweden)

    Qiang Cheng

    2013-01-01

    Full Text Available Traditional approaches about error modeling and analysis of machine tool few consider the probability characteristics of the geometric error and volumetric error systematically. However, the individual geometric error measured at different points is variational and stochastic, and therefore the resultant volumetric error is aslo stochastic and uncertain. In order to address the stochastic characteristic of the volumetric error for multiaxis machine tool, a new probability analysis mathematical model of volumetric error is proposed in this paper. According to multibody system theory, a mean value analysis model for volumetric error is established with consideration of geometric errors. The probability characteristics of geometric errors are obtained by statistical analysis to the measured sample data. Based on probability statistics and stochastic process theory, the variance analysis model of volumetric error is established in matrix, which can avoid the complex mathematics operations during the direct differential. A four-axis horizontal machining center is selected as an illustration example. The analysis results can reveal the stochastic characteristic of volumetric error and are also helpful to make full use of the best workspace to reduce the random uncertainty of the volumetric error and improve the machining accuracy.

  19. Volumetric and two-dimensional image interpretation show different cognitive processes in learners

    NARCIS (Netherlands)

    van der Gijp, Anouk; Ravesloot, C.J.; van der Schaaf, Marieke F; van der Schaaf, Irene C; Huige, Josephine C B M; Vincken, Koen L; Ten Cate, Olle Th J; van Schaik, JPJ

    2015-01-01

    RATIONALE AND OBJECTIVES: In current practice, radiologists interpret digital images, including a substantial amount of volumetric images. We hypothesized that interpretation of a stack of a volumetric data set demands different skills than interpretation of two-dimensional (2D) cross-sectional imag

  20. The Efficacy of Postoperative Wound Infusion with Bupivacaine for Pain Control after Cesarean Delivery: Randomized Double Blind Clinical Trial

    Directory of Open Access Journals (Sweden)

    Azin Alavi

    2007-06-01

    Full Text Available Objective: This study investigated the efficacy of bupivacaine wound infusion for pain control and opioid sparing effect after cesarean delivery.Materials and methods: We conducted a randomized double blind, placebo controlled clinical trial on 60 parturients undergoing cesarean section at a university hospital in Tehran. Patients were randomized to receive a pump infusion system that was filled with either 0.25% bupivacaine or equal volume of distilled water. A catheter was placed above the fascia and connected to electronic pump for 24 hours. Postoperative analog pain scores and morphine consumption were assessed at 6, 12 and 24 hours. Also time interval to first ambulation, length of hospitalization, complications and patient satisfaction were recorded. Data were analyzed using the SPSS software and P < 0.05 was considered statistically significant. Mann-Whitney u-test, student t-test and chi-square were used. Results: There were no differences in patient demographics and length of hospitalization and patient-generated resting pain scores between the two groups. Pain scores after coughing and leg raise during the first 6 postoperative hours were significantly less in the Bupivacaine group (P<0.001. The total dose of morphine consumption during the 24 hours study period was 2.5 ± 2.5 mg vs. 7.3 ± 2.7 mg for the bupivacaine and control groups, respectively (P<0.001. Compared with the control group, time to first ambulation was shorter in the bupivacaine group (11± 5h vs. 16 ± 4h (P< 0.01. Conclusion: Bupivacaine wound infusion was a simple and safe technique that provides effective analgesia and reduces morphine requirements after cesarean delivery.

  1. Ionic Polymer Microactuator Activated by Photoresponsive Organic Proton Pumps

    Directory of Open Access Journals (Sweden)

    Khaled M. Al-Aribe

    2015-10-01

    Full Text Available An ionic polymer microactuator driven by an organic photoelectric proton pump transducer is described in this paper. The light responsive transducer is fabricated by using molecular self-assembly to immobilize oriented bacteriorhodopsin purple membrane (PM patches on a bio-functionalized porous anodic alumina (PAA substrate. When exposed to visible light, the PM proton pumps produce a unidirectional flow of ions through the structure’s nano-pores and alter the pH of the working solution in a microfluidic device. The change in pH is sufficient to generate an osmotic pressure difference across a hydroxyethyl methacrylate-acrylic acid (HEMA-AA actuator shell and induce volume expansion or contraction. Experiments show that the transducer can generate an ionic gradient of 2.5 μM and ionic potential of 25 mV, producing a pH increase of 0.42 in the working solution. The ΔpH is sufficient to increase the volume of the HEMA-AA microactuator by 80%. The volumetric transformation of the hydrogel can be used as a valve to close a fluid transport micro-channel or apply minute force to a mechanically flexible microcantilever beam.

  2. High Volumetric Energy Density Hybrid Supercapacitors Based on Reduced Graphene Oxide Scrolls.

    Science.gov (United States)

    Rani, Janardhanan R; Thangavel, Ranjith; Oh, Se-I; Woo, Jeong Min; Chandra Das, Nayan; Kim, So-Yeon; Lee, Yun-Sung; Jang, Jae-Hyung

    2017-07-12

    The low volumetric energy density of reduced graphene oxide (rGO)-based electrodes limits its application in commercial electrochemical energy storage devices that require high-performance energy storage capacities in small volumes. The volumetric energy density of rGO-based electrode materials is very low due to their low packing density. A supercapacitor with enhanced packing density and high volumetric energy density is fabricated using doped rGO scrolls (GFNSs) as the electrode material. The restacking of rGO sheets is successfully controlled through synthesizing the doped scroll structures while increasing the packing density. The fabricated cell exhibits an ultrahigh volumetric energy density of 49.66 Wh/L with excellent cycling stability (>10 000 cycles). This unique design strategy for the electrode material has significant potential for the future supercapacitors with high volumetric energy densities.

  3. Global segmentation and curvature analysis of volumetric data sets using trivariate B-spline functions.

    Science.gov (United States)

    Soldea, Octavian; Elber, Gershon; Rivlin, Ehud

    2006-02-01

    This paper presents a method to globally segment volumetric images into regions that contain convex or concave (elliptic) iso-surfaces, planar or cylindrical (parabolic) iso-surfaces, and volumetric regions with saddle-like (hyperbolic) iso-surfaces, regardless of the value of the iso-surface level. The proposed scheme relies on a novel approach to globally compute, bound, and analyze the Gaussian and mean curvatures of an entire volumetric data set, using a trivariate B-spline volumetric representation. This scheme derives a new differential scalar field for a given volumetric scalar field, which could easily be adapted to other differential properties. Moreover, this scheme can set the basis for more precise and accurate segmentation of data sets targeting the identification of primitive parts. Since the proposed scheme employs piecewise continuous functions, it is precise and insensitive to aliasing.

  4. The duct selective volumetric receiver: potential for different selectivity strategies and stability issues

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Casals, X. [Universidad Pontificia Comillas-ICAI, Madrid (Spain). Dept. de Fluidos y Calor; Ajona, J.I. [Departamento de Energia Solar, Viessemann, Poligono Industrial San Marcos, Getafe (Spain)

    1999-07-01

    Recently much theoretical and experimental work has been conducted on volumetric receivers. However, not much attention has been paid to the possibilities of using different selectivity mechanisms to minimize radiation thermal losses, which are the main ones at high operating temperature. In this paper we present a duct volumetric receiver model and its results, which allow the evaluation of different selectivity strategies such as: conventional {epsilon}/{alpha}, geometry, frontal absorption and diffuse/specular reflection. We propose a new concept of selective volumetric receivers based on a solar-specular/infrared-diffuse radiative behaviour and evaluate its potential for efficiency improvement. In recent work on volumetric receivers based on simplified models, it has been concluded that the duct volumetric receiver is inherently unstable when working with high solar flux. We didn't find any unstable receiver behaviour even at very high solar fluxes, and conclude that a substantial potential for efficiency improvement exists if selectivity mechanisms are properly combined. (author)

  5. Enhanced volumetric visualization for real time 4D intraoperative ophthalmic swept-source OCT.

    Science.gov (United States)

    Viehland, Christian; Keller, Brenton; Carrasco-Zevallos, Oscar M; Nankivil, Derek; Shen, Liangbo; Mangalesh, Shwetha; Viet, Du Tran; Kuo, Anthony N; Toth, Cynthia A; Izatt, Joseph A

    2016-05-01

    Current-generation software for rendering volumetric OCT data sets based on ray casting results in volume visualizations with indistinct tissue features and sub-optimal depth perception. Recent developments in hand-held and microscope-integrated intrasurgical OCT designed for real-time volumetric imaging motivate development of rendering algorithms which are both visually appealing and fast enough to support real time rendering, potentially from multiple viewpoints for stereoscopic visualization. We report on an enhanced, real time, integrated volumetric rendering pipeline which incorporates high performance volumetric median and Gaussian filtering, boundary and feature enhancement, depth encoding, and lighting into a ray casting volume rendering model. We demonstrate this improved model implemented on graphics processing unit (GPU) hardware for real-time volumetric rendering of OCT data during tissue phantom and live human surgical imaging. We show that this rendering produces enhanced 3D visualizations of pathology and intraoperative maneuvers compared to standard ray casting.

  6. Intravitreal methotrexate infusion for proliferative vitreoretinopathy

    Directory of Open Access Journals (Sweden)

    Sadaka A

    2016-09-01

    Full Text Available Ama Sadaka,1 Robert A Sisk,1–3 James M Osher,1,3 Okan Toygar,4 Melinda K Duncan,5 Christopher D Riemann1,3 1Department of Ophthalmology, University of Cincinnati College of Medicine, 2Department of Opthalmology, Cincinnati Children’s Hospital Medical Center, 3Cincinnati Eye Institute, Cincinnati, OH, USA; 4Department of Ophthalmology, Bahcesehir University Medical Faculty, Istanbul, Turkey; 5Department of Biological Sciences, University of Delaware, Newark, DE, USA Purpose: The purpose of this study was to evaluate intravitreal methotrexate infusion (IMI during pars plana vitrectomy (PPV for retinal detachment in patients with high risk for the development of proliferative vitreoretinopathy (PVR.Methods: Patients presenting with severe recurrent PVR with tractional retinal detachment and/or a history of severe ocular inflammation were treated with IMI. Clinical outcomes were determined from a retrospective medical chart review.Results: Twenty-nine eyes presenting with either tractional retinal detachment and recurrent PVR (n=22 or a history of severe inflammation associated with high PVR risk (n=7 received IMI during PPV. Best-corrected visual acuity at 6 months was ≥20/200 in 19 of 29 eyes (66% and remained stable or improved compared with initial presentation in 24 of 29 eyes (83%. At the last follow-up examination, the retinas of 26 of 29 eyes (90% remained attached after IMI while three eyes required another reattachment procedure. Three additional eyes (10% developed recurrent limited PVR without recurrent RD and were observed. No complications attributable to IMI occurred during a mean follow-up of 27 months.Conclusion: Eyes at high risk for PVR development due to a history of prior PVR or intraocular inflammation had a low incidence of PVR following IMI at the time of PPV for RD repair. No significant safety issues from IMI were observed in this series. Keywords: tractional retinal detachment, recurrent retinal detachment, pars

  7. Herbal infusions used for induced abortion.

    Science.gov (United States)

    Ciganda, Carmen; Laborde, Amalia

    2003-01-01

    Plants and herbs have been used to induce abortions but there is very little published information describing the commonly used ones. The purpose of this report is to describe the herbal products used to induce abortions, and to enhance awareness and understanding of their toxic effects. A descriptive retrospective survey was conducted on the calls received by the Montevideo Poison Centre between 1986 and 1999 concerning the ingestion of herbal infusions with abortive intent. A total of 86 cases involving 30 different plant species were identified. The species most frequently involved were ruda (Ruta chalepensis/graveolens), cola de quirquincho (Lycopodium saururus), parsley (Petroselinum hortense), and an over-the-counter herbal product named Carachipita. The components of Carachipita are pennyroyal (Mentha pulegium), yerba de la perdiz (Margiricarpus pinnatus), oregano (Origanum vulgare), and guaycuri (Statice brasiliensis). Abortion occurred in 23 cases after the ingestion of parsley, ruda, Carachipita, celery, Cedron, francisco alvarez, floripon, espina colorada. Out of the 23 cases, 15 involved the only the ingestion of plants, 4 cases used injected drugs (presumably hormones), and in 4 cases there was associated self-inflicted instrumental manipulation. Multiple organ system failure occurred in those patients who had ingested ruda (alone or in combination with parsley or fennel), Carachipita, arnica, or bardana. Deaths occurred in one case of Carachipita ingestion and in 4 cases of ruda ingestion (2 cases of ruda alone, 2 cases of ruda with parsley and fennel). Self-inflicted instrumental manipulations were found in 4 of the patients with multiple organ system failure and in one of those who died. The results of this report are not conclusive, but it appears that the ingestion of plants to induce abortion involves the risk of severe morbidity and mortality.

  8. Melissa officinalis and Passiflora caerulea infusion as physiological stress decreaser

    National Research Council Canada - National Science Library

    Feliú-Hemmelmann, Karina; Monsalve, Francisco; Rivera, César

    2013-01-01

    The objective of this study was to determine the effect of a Melissa officinalis and Passiflora caerulea infusion on the severity of physiological chronic stress induced by movement restriction in CF-1 mice...

  9. Infusing Social Responsibility into the Curriculum and Cocurriculum: Campus Examples

    Science.gov (United States)

    Reason, Robert D.

    2013-01-01

    This chapter highlights good practices and lessons learned for infusing social responsibility--contributing to the larger community and taking seriously the perspectives of others--as outcomes of college.

  10. Antioxidant and astroprotective effects of a Pulicaria incisa infusion.

    Science.gov (United States)

    Elmann, Anat; Telerman, Alona; Mordechay, Sharon; Erlank, Hilla; Ofir, Rivka

    2012-01-01

    Oxidative stress is involved in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. Astrocytes, the most abundant glial cells in the brain, protect neurons from reactive oxygen species (ROS) and provide them with trophic support, such as glial-derived neurotrophic factor (GDNF). Thus, any damage to astrocytes will affect neuronal survival. In the present study, an infusion prepared from the desert plant Pulicaria incisa (Pi) was tested for its protective and antioxidant effects on astrocytes subjected to oxidative stress. The Pi infusion attenuated the intracellular accumulation of ROS following treatment with hydrogen peroxide and zinc and prevented the H(2)O(2)-induced death of astrocytes. The Pi infusion also exhibited an antioxidant effect in vitro and induced GDNF transcription in astrocytes. It is proposed that this Pi infusion be further evaluated for use as a functional beverage for the prevention and/or treatment of brain injuries and neurodegenerative diseases in which oxidative stress plays a role.

  11. Attribute based selection of thermoplastic resin for vacuum infusion process

    DEFF Research Database (Denmark)

    Prabhakaran, R.T. Durai; Lystrup, Aage; Løgstrup Andersen, Tom

    2011-01-01

    The composite industry looks toward a new material system (resins) based on thermoplastic polymers for the vacuum infusion process, similar to the infusion process using thermosetting polymers. A large number of thermoplastics are available in the market with a variety of properties suitable...... for different engineering applications, and few of those are available in a not yet polymerised form suitable for resin infusion. The proper selection of a new resin system among these thermoplastic polymers is a concern for manufactures in the current scenario and a special mathematical tool would...... be beneficial. In this paper, the authors introduce a new decision making tool for resin selection based on significant attributes. This article provides a broad overview of suitable thermoplastic material systems for vacuum infusion process available in today’s market. An illustrative example—resin selection...

  12. Resin Infusion Rigidized Inflatable Concept Development and Demonstration Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Utilizing resin infusion to rigidize an inflatable structure and form fiber-reinforced composites on-orbit is a novel concept that builds on current NASA technology...

  13. Infusing Social Responsibility into the Curriculum and Cocurriculum: Campus Examples

    Science.gov (United States)

    Reason, Robert D.

    2013-01-01

    This chapter highlights good practices and lessons learned for infusing social responsibility--contributing to the larger community and taking seriously the perspectives of others--as outcomes of college.

  14. Metabolic and antioxidant profiles of herbal infusions and decoctions.

    Science.gov (United States)

    Fotakis, Charalambos; Tsigrimani, Diamantina; Tsiaka, Thalia; Lantzouraki, Dimitra Z; Strati, Irini F; Makris, Constantinos; Tagkouli, Dimitra; Proestos, Charalampos; Sinanoglou, Vassilia J; Zoumpoulakis, Panagiotis

    2016-11-15

    This study implements NMR metabolomics and spectrophotometric studies (Folin-Ciocalteu, FRAP, ABTS) to infusions and decoctions of ten plant species in order to assess and compare the metabolic and antioxidant profiles for each botanical family. Multivariate and univariate data analyses highlighted the differences among the samples and pinpointed specific classes of compounds for each plant species as well as infusions and decoctions. The identified phenolic compounds by NMR, as well as the antioxidant profile, framed a trend of increased values in infusions compared to the decoctions. Moreover, the infusion procedure positively affected the extractability of the phenolic compounds compared to decoctions. The highest total phenolic content was found in Mentha spicata, while the lowest in Matricaria chamomilla preparations, irrespective of the preparation method. The preparation time for the decoctions was examined showing that the 15min preparations were generally found richer in phenolics and of higher antioxidant capacity.

  15. A Framework for Infusing Multicultural Curriculum into Gifted Education.

    Science.gov (United States)

    Ford, Donna Y.; Harris, J. John, III

    2000-01-01

    This article offers a framework for infusing multicultural curriculum into gifted education that integrates two, heretofore, parallel models in education, Benjamin Bloom's taxonomy of educational objectives (1956) and Banks and Banks' (1993) model of multicultural education. (Contains 15 references.) (DB)

  16. The Impact of a Pure Protein Load on the Glucose Levels in Type 1 Diabetes Patients Treated with Insulin Pumps

    OpenAIRE

    Tomasz Klupa; Teresa Benbenek-Klupa; Bartlomiej Matejko; Sandra Mrozinska; Malecki, Maciej T.

    2015-01-01

    We aimed to estimate the impact of ingestion of a pure protein load on the glucose levels in T1DM patients treated with insulin pumps. We examined 10 T1DM patients (6 females, mean age—32.3 years, mean HbA1c—6.8%) treated with insulin pumps equipped with a continuous glucose monitoring system (CGMS). In Phase I, baseline insulin infusion was optimized to minimize the differences in fasting glucose levels to less than 30 mg/dL between any two time points between 9 a.m. and 3 p.m. In Phase II, ...

  17. Volumetric and two-dimensional image interpretation show different cognitive processes in learners.

    Science.gov (United States)

    van der Gijp, Anouk; Ravesloot, Cécile J; van der Schaaf, Marieke F; van der Schaaf, Irene C; Huige, Josephine C B M; Vincken, Koen L; Ten Cate, Olle Th J; van Schaik, Jan P J

    2015-05-01

    In current practice, radiologists interpret digital images, including a substantial amount of volumetric images. We hypothesized that interpretation of a stack of a volumetric data set demands different skills than interpretation of two-dimensional (2D) cross-sectional images. This study aimed to investigate and compare knowledge and skills used for interpretation of volumetric versus 2D images. Twenty radiology clerks were asked to think out loud while reading four or five volumetric computed tomography (CT) images in stack mode and four or five 2D CT images. Cases were presented in a digital testing program allowing stack viewing of volumetric data sets and changing views and window settings. Thoughts verbalized by the participants were registered and coded by a framework of knowledge and skills concerning three components: perception, analysis, and synthesis. The components were subdivided into 16 discrete knowledge and skill elements. A within-subject analysis was performed to compare cognitive processes during volumetric image readings versus 2D cross-sectional image readings. Most utterances contained knowledge and skills concerning perception (46%). A smaller part involved synthesis (31%) and analysis (23%). More utterances regarded perception in volumetric image interpretation than in 2D image interpretation (Median 48% vs 35%; z = -3.9; P Cognitive processes in volumetric and 2D cross-sectional image interpretation differ substantially. Volumetric image interpretation draws predominantly on perceptual processes, whereas 2D image interpretation is mainly characterized by synthesis. The results encourage the use of volumetric images for teaching and testing perceptual skills. Copyright © 2015 AUR. Published by Elsevier Inc. All rights reserved.

  18. Infusing Software Engineering Technology into Practice at NASA

    Science.gov (United States)

    Pressburger, Thomas; Feather, Martin S.; Hinchey, Michael; Markosia, Lawrence

    2006-01-01

    We present an ongoing effort of the NASA Software Engineering Initiative to encourage the use of advanced software engineering technology on NASA projects. Technology infusion is in general a difficult process yet this effort seems to have found a modest approach that is successful for some types of technologies. We outline the process and describe the experience of the technology infusions that occurred over a two year period. We also present some lessons from the experiences.

  19. Overview and tips for successful grant writing for infusion nurses.

    Science.gov (United States)

    Kwekkeboom, Kristine L

    2014-01-01

    Grant writing is an important step to building evidence for infusion nursing practice. This paper describes the role of the infusion nurse in developing a research proposal, identifying appropriate sources of funding, and preparing to write the grant application; identifies typical sections of a grant application and information necessary in each; and provides tips for writing an application that will contribute to a positive review.

  20. Pumping of titanium sapphire laser

    Science.gov (United States)

    Jelínková, H.; Vaněk, P.; Valach, P.; Hamal, K.; Kubelka, J.; Škoda, V.; Jelínek, M.

    1993-02-01

    Two methods of Ti:Sapphire pumping for the generation of tunable laser radiation in the visible region were studied. For coherent pumping, the radiation of the second harmonic of a Nd:YAP laser was used and a maximum output energy of E out=4.5 mJ was reached from the Ti:Sapphire laser. For noncoherent pumping, two different lengths of flashlamp pulses were used and a maximum of E out=300 mJ was obtained. Preliminary estimations of the wavelength range of tunability were made.