Nuclear power. Volume 1. Nuclear power plant design

International Nuclear Information System (INIS)

Pedersen, E.S.

1978-01-01

NUCLEAR POWER PLANT DESIGN is intended to be used as a working reference book for management, engineers and designers, and as a graduate-level text for engineering students. The book is designed to combine theory with practical nuclear power engineering and design experience, and to give the reader an up-to-date view of the status of nuclear power and a basic understanding of how nuclear power plants function. Volume 1 contains the following chapters; (1) nuclear reactor theory; (2) nuclear reactor design; (3) types of nuclear power plants; (4) licensing requirements; (5) shielding and personnel exposure; (6) containment and structural design; (7) main steam and turbine cycles; (8) plant electrical system; (9) plant instrumentation and control systems; (10) radioactive waste disposal (waste management) and (11) conclusion

Purification and characterization of factor VIII 1,689-Cys: a nonfunctional cofactor occurring in a patient with severe hemophilia A.

Science.gov (United States)

O'Brien, D P; Tuddenham, E G

1989-06-01

We have purified the factor VIII from a CRM+ Hemophilia A plasma (90 U/dL VIII:Ag but 0 U/dL VIII:C) and analyzed the protein before and after thrombin activation by Western blotting with monoclonal antibodies (MoAbs). Normal or patient citrated plasma was ultracentrifuged, cryo-ethanol-precipitated and chromatographed on Sepharose 6B. The void volume fractions were reduced and subjected to ion exchange chromatography yielding material of specific activity approximately 1,000 U/mg protein (VIII:C or VIII:Ag). Factor VIII purified in this way from normal plasma is fully activatable by thrombin with proteolytic fragmentation as previously described by F. Rotblat et al (Biochemistry 24: 4294, 1985). Factor VIII 1,689-Cys has the normal distribution of factor VIII light and heavy chains prior to thrombin activation. After exposure to thrombin the heavy chain polypeptides were fully proteolysed but the light chain was totally resistant to cleavage. This is consistent with the demonstration in the patient's leucocyte DNA of a C to T transition in codon 1,689 converting Arg to Cys at the light chain thrombin cleavage site as previously described by J. Gitschier et al (Blood 72:1022, 1988). Uncleaved light chain of Factor VIII 1,689-Cys is not released from von Willebrand factor (vWF) by thrombin, but this is not the sole cause of the functional defect since the protein purified free of vWF has no coagulant activity. We conclude that the functional defect in factor VIII 1,689-Cys is a consequence of failure to release the acidic peptide from the light chain upon thrombin activation.

Stereological estimation of the mean and variance of nuclear volume from vertical sections

DEFF Research Database (Denmark)

Sørensen, Flemming Brandt

1991-01-01

The application of assumption-free, unbiased stereological techniques for estimation of the volume-weighted mean nuclear volume, nuclear vv, from vertical sections of benign and malignant nuclear aggregates in melanocytic skin tumours is described. Combining sampling of nuclei with uniform...... probability in a physical disector and Cavalieri's direct estimator of volume, the unbiased, number-weighted mean nuclear volume, nuclear vN, of the same benign and malignant nuclear populations is also estimated. Having obtained estimates of nuclear volume in both the volume- and number distribution...... to the larger malignant nuclei. Finally, the variance in the volume distribution of nuclear volume is estimated by shape-independent estimates of the volume-weighted second moment of the nuclear volume, vv2, using both a manual and a computer-assisted approach. The working procedure for the description of 3-D...

Stereological estimation of the mean and variance of nuclear volume from vertical sections

DEFF Research Database (Denmark)

Sørensen, Flemming Brandt

1991-01-01

The application of assumption-free, unbiased stereological techniques for estimation of the volume-weighted mean nuclear volume, nuclear vv, from vertical sections of benign and malignant nuclear aggregates in melanocytic skin tumours is described. Combining sampling of nuclei with uniform...... probability in a physical disector and Cavalieri's direct estimator of volume, the unbiased, number-weighted mean nuclear volume, nuclear vN, of the same benign and malignant nuclear populations is also estimated. Having obtained estimates of nuclear volume in both the volume- and number distribution...... of volume, a detailed investigation of nuclear size variability is possible. Benign and malignant nuclear populations show approximately the same relative variability with regard to nuclear volume, and the presented data are compatible with a simple size transformation from the smaller benign nuclei...

The influence of prophylactic factor VIII in severe hemophilia A

Science.gov (United States)

Gissel, Matthew; Whelihan, Matthew F; Ferris, Lauren A; Mann, Kenneth G; Rivard, Georges E; Brummel-Ziedins, Kathleen E

2013-01-01

Introduction Hemophilia A individuals displaying a similar genetic defect have heterogeneous clinical phenotypes. Aim To evaluate the underlying effect of exogenous factor (f)VIII on tissue factor (Tf)-initiated blood coagulation in severe hemophilia utilizing both empirical and computational models. Methods We investigated twenty-five clinically severe hemophilia A patients. All individuals were on fVIII prophylaxis and had not received fVIII from 0.25 to 4 days prior to phlebotomy. Coagulation was initiated by the addition of Tf to contact-pathway inhibited whole blood ± an anti-fVIII antibody. Aliquots were quenched over 20 min and analyzed for thrombin generation and fibrin formation. Coagulation factor levels were obtained and used to computationally predict thrombin generation with fVIII set to either zero or its value at the time of the draw. Results Due to prophylactic fVIII, at the time of the blood draw, the individuals had fVIII levels that ranged from hemophilia A. The combination of each individual's coagulation factors (outside of fVIII) determine each individual's baseline thrombin potential and may affect bleeding risk. PMID:21899664

Factor VIII assay

Science.gov (United States)

... this page: //medlineplus.gov/ency/article/003678.htm Factor VIII assay To use the sharing features on ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health ...

[Ehler-Danlos syndrome type VIII].

Science.gov (United States)

Ciarloni, L; Perrigouard, C; Lipsker, D; Cribier, B

2010-03-01

Ehlers-Danlos syndrome (EDS) comprises a heterogeneous group of diseases involving genetic collagen fibre impairment. We describe a case of a patient presenting the rare type VIII, in which dermatitis ocre was associated with parodontal disease, and which was diagnosed late. A 29-year-old man consulted for a pretibial ulcer present for seven years, resulting from a post-traumatic haematoma that had failed to heal. In view of the longiliner morphology, it had previously been diagnosed as Marfan syndrome. Subsequently, edentation was observed as well as "alveolar bone fragility". Examination revealed a marfanoid morphotype, a pretibial ulcer set within long-standing bilateral dermatitis ocre and papyraceous scars, but no joint hyperlaxity or cutaneous hyperelasticity. The diagnosis was consequently corrected to EDS type VIII. Type VIII is a rare form of EDS, and the molecular mechanism is poorly understood. The involvement of parodontal connective tissue suggests impairment of collagen I and III proteins. It is important to identify this type of the disease since it involves parodontal disease for which early treatment is required in order to try to prevent edentation. The present case demonstrates the importance of diagnosis, which may be based upon appearance of bilateral dermatitis ocre from the age of 15 years associated with skin fragility. This sign is not part of the classical picture of Marfan syndrome, with which EDS type VIII is often confounded. Copyright 2009 Elsevier Masson SAS. All rights reserved.

Differential proteolytic activation of factor VIII-von Willebrand factor complex by thrombin

International Nuclear Information System (INIS)

Hill-Eubanks, D.C.; Parker, C.G.; Lollar, P.

1989-01-01

Blood coagulation factor VIII (fVIII) is a plasma protein that is decreased or absent in hemophilia A. It is isolated as a mixture of heterodimers that contain a variably sized heavy chain and a common light chain. Thrombin catalyzes the activation of fVIII in a reaction that is associated with cleavages in both types of chain. The authors isolated a serine protease from Bothrops jararacussu snake venom that catalyzes thrombin-like heavy-chain cleavage but not light-chain cleavage in porcine fVIII as judged by NaDodSO 4 /PAGE and N-terminal sequence analysis. Using a plasma-free assay of the ability of activated 125 I-fVIII to function as a cofactor in the activation of factor X by factor IXa, they found that fVIII is activated by the venom enzyme. The venom enzyme-activated fVIII was isolated in stable form by cation-exchange HPLC. von Willebrand factor inhibited venom enzyme-activated fVIII but not thrombin-activated fVIII. These results suggest that the binding of fVIII to von Willebrand factor depends on the presence of an intact light chain and that activated fVIII must dissociate from von Willebrand factor to exert its cofactor effect. Thus, proteolytic activation of fVIII-von Willebrand factor complex appears to be differentially regulated by light-chain cleavage to dissociate the complex and heavy-chain cleavage to activate the cofactor function

Structure and stability of hexa-aqua V(III) cations in vanadium redox flow battery electrolytes.

Science.gov (United States)

Vijayakumar, M; Li, Liyu; Nie, Zimin; Yang, Zhenguo; Hu, JianZhi

2012-08-07

The vanadium(III) cation structure in mixed acid based electrolyte solution from vanadium redox flow batteries is studied by (17)O and (35/37)Cl nuclear magnetic resonance (NMR) spectroscopy, electronic spectroscopy and density functional theory (DFT) based computational modelling. Both computational and experimental results reveal that the V(III) species can complex with counter anions (sulfate/chlorine) depending on the composition of its solvation sphere. By analyzing the powder precipitate it was found that the formation of sulfate complexed V(III) species is the crucial process in the precipitation reaction. The precipitation occurs through nucleation of neutral species formed through deprotonation and ion-pair formation process. However, the powder precipitate shows a multiphase nature which warrants multiple reaction pathways for precipitation reaction.

Reprocessing of the spent nuclear fuel, I-VIII, Part VIII

International Nuclear Information System (INIS)

Gal, I.

1963-02-01

This volume includes the following three reports: Separation of uranium, plutonium and fission products on zirconium phosphate; Separation of uranium, plutonium and fission products on zirconium phosphate, Part 1 - Adsorption equilibria and kinetics; and Adsorption of dibutyl phosphates and monobutyl phosphates on inorganic oxides

77 FR 64401 - Order of Succession for HUD Region VIII

Science.gov (United States)

2012-10-19

... Region VIII AGENCY: Office of Field Policy and Management, HUD. ACTION: Notice of Order of Succession... Field Offices (Region VIII). This Order of Succession supersedes all previous Orders of Succession for HUD Region VIII. DATES: Effective Date: October 9, 2012. FOR FURTHER INFORMATION CONTACT: Lawrence D...

Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume II. Proliferation resistance

International Nuclear Information System (INIS)

1980-06-01

The purpose of this volume is limited to an assessment of the relative effects that particular choices of nuclear-power systems, for whatever reasons, may have on the possible spread of nuclear-weapons capabilities. This volume addresses the concern that non-nuclear-weapons states may be able to initiate efforts to acquire or to improve nuclear-weapons capabilities through civilian nuclear-power programs; it also addresses the concern that subnational groups may obtain and abuse the nuclear materials or facilities of such programs, whether in nuclear-weapons states (NWS's) or nonnuclear-weapons states (NNW's). Accordingly, this volume emphasizes one important factor in such decisions, the resistance of nuclear-power systems to the proliferation of nuclear-weapons capabilities

Reprocessing of the spent nuclear fuel, I-VIII, Part VIII; Prerada isluzenog nuklearnog goriva, I-VIII, VIII Deo

Energy Technology Data Exchange (ETDEWEB)

Gal, I [Institute of Nuclear Sciences Boris Kidric, Laboratorija za hemiju visoke aktivnosti, Vinca, Beograd (Serbia and Montenegro)

1963-02-15

This volume includes the following three reports: Separation of uranium, plutonium and fission products on zirconium phosphate; Separation of uranium, plutonium and fission products on zirconium phosphate, Part 1 - Adsorption equilibria and kinetics; and Adsorption of dibutyl phosphates and monobutyl phosphates on inorganic oxides.

Bibliography on nuclear medicine. Volumes 28--30

International Nuclear Information System (INIS)

1975-07-01

References to 3177 publications related to nuclear medicine announced in Nuclear Science Abstracts (NSA) volumes 28(July-Dec. 1973), 29(Jan-June 1974), and 30(July-Dec. 1974) are contained in this bibliography. Subject, report number, and personal author indexes are included. (U.S.)

The Safety and Feasibility of Three-Dimensional Visualization Technology Assisted Right Posterior Lobe Allied with Part of V and VIII Sectionectomy for Right Hepatic Malignancy Therapy.

Science.gov (United States)

Hu, Min; Hu, Haoyu; Cai, Wei; Mo, Zhikang; Xiang, Nan; Yang, Jian; Fang, Chihua

2018-05-01

Hepatectomy is the optimal method for liver cancer; the virtual liver resection based on three-dimensional visualization technology (3-DVT) could provide better preoperative strategy for surgeon. We aim to introduce right posterior lobe allied with part of V and VIII sectionectomy assisted by 3-DVT as a promising treatment for massive or multiple right hepatic malignancies to retain maximum residual liver volume on the basis of R0 resection. Among 126 consecutive patients who underwent hepatectomy, 9 (7%) underwent right posterior lobe allied with part of V and VIII sectionectomy. 21 (17%) underwent right hemihepatectomy (RH). The virtual RH was performed with 3-DVT, which provided better observation of spatial position relationship between tumor and vessels, and the more accurate estimation of the remnant liver volume. If remnant liver volume was right posterior lobe allied with part of V and VIII sectionectomy should be undergone. Then, the precut line ought to be planned on the basis of protecting the portal branch of subsegment 5 and 8. The postoperative outcome of patients was compared before and after propensity score matching. Nine patients meeting the eligibility criteria received right posterior lobe allied with part of V and VIII sectionectomy. The variables, including the overall mean operation time, blood transfusion, operation length, liver function, and postoperative complications, were similar between two groups before and after propensity matching. The postoperative first, third, fifth, and seventh days mean value of aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin (ALB), and total bilirubin had no significant difference compared with preoperative value. One patient in each group had recurrence six months after surgery. Right posterior lobe allied with part of V and VIII sectionectomy based on 3-DVT is safe and feasible surgery way, and can be a very promising method in massive or multiple right hepatic malignancy therapy.

Factoring in Factor VIII With Acute Ischemic Stroke.

Science.gov (United States)

Siegler, James E; Samai, Alyana; Albright, Karen C; Boehme, Amelia K; Martin-Schild, Sheryl

2015-10-01

There is growing research interest into the etiologies of cryptogenic stroke, in particular as it relates to hypercoagulable states. An elevation in serum levels of the procoagulant factor VIII is recognized as one such culprit of occult cerebral infarctions. It is the objective of the present review to summarize the molecular role of factor VIII in thrombogenesis and its clinical use in the diagnosis and prognosis of acute ischemic stroke. We also discuss the utility of screening for serum factor VIII levels among patients at risk for, or those who have experienced, ischemic stroke. © The Author(s) 2015.

Extended analyses of Se VII and Se VIII

International Nuclear Information System (INIS)

Vankleef, Th.A.M.; Joshi, Y.N.

1984-01-01

Joshi et al. (1984) have conducted an analysis of the 3d8 4s-3d8 4p transitions in As VII. The present investigation is concerned with an analysis of similar transitions in Se VIII. The selenium spectrum was photographed in the 400-1200-A wavelength region on a variety of normal-incidence spectrographs. Attention is given to least-squares-fit (LSF) and Hartree-Fock (HF) parameter values for the 3d9 4d configuration of Se VII, LSF and HF parameter values for the 3d8 4s and 3d8 4p configurations of Se VIII, the energy and composition of the levels of the 3d9 4d configuration of Se VII, classified lines in Se VII, energy levels and composition of the 3d8 4s configuration and the revised and newly determined levels of the 3d8 4p configuration of Se VIII, and newly classified lines of Se VIII. 15 references

Classification of tubulo-papillary renal cortical tumours using estimates of nuclear volume

DEFF Research Database (Denmark)

Brooks, B; Sørensen, Flemming Brandt; Olsen, S

1993-01-01

The classification of renal cortical tumours is problematic, with no clear division of benign from malignant tumours. Unbiased stereological estimates of volume-weighted nuclear volume (nuclear vv) were obtained by point sampling of nuclear intercepts in a retrospective study of 36 variably sized...

Applications of the gas chromatography in the nuclear science and technology; Aplicaciones de la cromatografia de gases a la ciencia y tecnologia nuclear

Energy Technology Data Exchange (ETDEWEB)

Gasco Sanchez, L

1972-07-01

This paper is a review on the applications of the gas chromatography in the nuclear science and technology published up to December 1971. Its contents has been classified under the following heads; I) Radiogaschromatography, II) Isotope separation, III) Preparation of labelled molecules, IV) Nuclear fuel cycle, V) Nuclear reactor technology, VI) Irradiation chemistry, VIl) Separation of me tal compounds in gas phase, VIII) Applications of the gas chromatography carried out at the Junta de Energia Nuclear, Spain. Arapter VIII only includes the investigations carried out from January 1969 to December 1971. Previous investigations in this field has been published elsewhere. (Author)

Idiopathic Acquired Hemophilia A with Undetectable Factor VIII Inhibitor

Directory of Open Access Journals (Sweden)

Nicholas B. Abt

2014-01-01

Full Text Available Objective. We present the case of a 73-year-old female, with no family or personal history of a bleeding disorder, who had a classic presentation for acquired hemophilia A. Factor VIII activity was low but detectable and a factor VIII inhibitor was undetectable. Methods. The patient’s plasma was comprehensively studied to determine the cause of the acquired coagulopathy. Using the Nijmegen modification of the Bethesda assay, no factor VIII autoantibody was measureable despite varying the incubation time from 1 to 3 hours. Results. The aPTT was prolonged at 46.8 seconds, which did not correct in the 4 : 1 mix but did with 1 : 1 mix. Using a one stage factor VIII activity assay, the FVIII activity was 16% and chromogenic FVIII activity was also 16%. The patient was treated with recombinant FVII and transfusion, significantly reducing bleeding. Long-term therapy was initiated with cyclophosphamide and prednisone with normalization of FVIII activity. Conclusions. Physicians can be presented with the challenging clinical picture of an acquired factor VIII inhibitor without a detectable inhibitor by the Bethesda assay. Standard therapy for an acquired hemophilia A should be considered.

4p-5s transitions in YVII, VIII, ZrVIII, IX, NbIX, X and MoX, XI

International Nuclear Information System (INIS)

Rahimullah, K.; Chaghtai, M.S.Z.; Khatoon, S.

1976-01-01

The spectra of Y VII, VIII, Zr VIII, IX, Nb X and Mo X, XI are studied for the first time and the 1971 analysis of Nb IX is improved. By analyses of the transitions 4s 2 4psup(k)-4s 2 4psup(k-1)5s all the levels of the configurations 4p 3 , 4p 2 5s, 4p 2 and 4p5s are established in the spectra concerned. (Auth.)

Reproducibility of mean nuclear volume and correlation with mean nuclear area in breast cancer

DEFF Research Database (Denmark)

Baak, J P; Ladekarl, M; Sørensen, Flemming Brandt

1994-01-01

reproducible and strongly correlated with nuclear vv assessed in the TOTAL. In invasive breast cancer assessments in the whole tumor section can be used if delineation of the measurement area cannot be done easily. In small areas with a limited number of nuclei (eg, microinvasive parts) MNA can be easier......Previous studies have shown that quantitative, histopathologic features obtained from a carefully selected area in the tumor section ("selective" approach) have a strong prognostic value in breast cancer. On the other hand, it was found that mean nuclear volume estimation in the whole area...... as to their intraobserver and interobserver reproducibility in 22 invasive breast cancer cases. The mean nuclear volume (nuclear vv) was assessed both in the most atypical area (AREA) (selected on morphologic criteria) and in the whole tumor section (TOTAL). Furthermore, the correlation with mean nuclear (profile) area...

Nuclear legislation analytical study. Regulatory and institutional framework for nuclear activities in OECD member countries. Volume II

International Nuclear Information System (INIS)

1984-01-01

This study is part of a series of analytical studies of the major aspects of nuclear legislation in OECD Member countries and is published in two volumes. This volume II of the study is a revision and an expansion of a 1969 study concerning the organisation and general regime governing nuclear activities. The national studies were prepared, to the extent possible, following a standard plan for all countries to facilitate information retrieval and comparison. This volume also contains tables of international conventions of relevance to the nuclear field. (NEA) [fr

9th Pacific Basin Nuclear Conference. Nuclear energy, science and technology - Pacific partnership. Proceedings Volume 2

International Nuclear Information System (INIS)

1994-04-01

The theme of the 9th Pacific Basin Nuclear Conference held in Sydney from 1-6 May 1994, embraced the use of atom in energy production and in science and technology. The focus was on selected topics of current and on-going interest to countries around the Pacific Basin. The two-volume proceedings include both invited and contributed papers which have been indexed separately. This document, Volume 2 covers the following topics: education and training in Nuclear Science, public acceptance, nuclear safety and radiation protection, nuclear fuel resources and their utilisation, research reactors, cyclotrons and accelerators. refs., tabs., figs., ills

40 CFR Appendix Viii to Part 600 - Fuel Economy Label Formats

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Fuel Economy Label Formats VIII... POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Pt. 600, App. VIII Appendix VIII to Part 600—Fuel Economy Label Formats EC01MY92.117 EC01MY92.118 EC01MY92.119 EC01MY92.120...

Intralesional and metastatic heterogeneity in malignant melanomas demonstrated by stereologic estimates of nuclear volume

DEFF Research Database (Denmark)

Sørensen, Flemming Brandt; Erlandsen, M

1990-01-01

Regional variability of nuclear 3-dimensional size can be estimated objectively using point-sampled intercepts obtained from different, defined zones within individual neoplasms. In the present study, stereologic estimates of the volume-weighted mean nuclear volume, nuclear vv, within peripheral...... melanomas showed large interindividual variation. This finding emphasizes that unbiased estimates of nuclear vv are robust to regional heterogeneity of nuclear volume and thus suitable for purposes of objective, quantitative malignancy grading of melanomas....

Nuclear regulatory legislation, 104th Congress, Volume 1, No. 4

International Nuclear Information System (INIS)

1997-12-01

This document is the first of two volumes compiling statutes and material pertaining to nuclear regulatory legislation through the 104th Congress, 2nd Session. It is intended for use as a U.S. Nuclear Regulatory Commission (NRC) internal resource document. Legislative information reproduced in this document includes portions of the Atomic Energy Act, Energy Reorganization Act, Low-Level Radioactive Waste Policy Amendments Act, and Nuclear Waste Policy Act. Other information included in this volume pertains to NRC user fees, NRC authorizations, the Inspector General Act, and the Administrative Procedure Act

Nuclear regulatory legislation, 104th Congress, Volume 1, No. 4

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-12-01

This document is the first of two volumes compiling statutes and material pertaining to nuclear regulatory legislation through the 104th Congress, 2nd Session. It is intended for use as a U.S. Nuclear Regulatory Commission (NRC) internal resource document. Legislative information reproduced in this document includes portions of the Atomic Energy Act, Energy Reorganization Act, Low-Level Radioactive Waste Policy Amendments Act, and Nuclear Waste Policy Act. Other information included in this volume pertains to NRC user fees, NRC authorizations, the Inspector General Act, and the Administrative Procedure Act.

Stereological estimation of nuclear volume in benign and atypical meningiomas

DEFF Research Database (Denmark)

Madsen, C; Schrøder, H D

1993-01-01

A stereological estimation of nuclear volume in benign and atypical meningiomas was made. The aim was to investigate whether this method could discriminate between these two meningeal neoplasms. The difference was significant and it was moreover seen that there was no overlap between the two groups....... The results demonstrate that atypical meningiomas can be distinguished from benign meningiomas by an objective stereological estimation of nuclear volume....

Ehlers-Danlos Syndrome Type VIII: A Rare Cause of Leg Ulcers in Young Patients

Directory of Open Access Journals (Sweden)

Sophie Ronceray

2013-01-01

Full Text Available Ehlers-Danlos syndrome type VIII (EDS-VIII is a very rare autosomal dominant disease characterized by early-onset periodontitis associated with features of Ehlers-Danlos syndrome. We report a 32-year-old man whose chronic leg ulcer led to the diagnosis of EDS-VIII. He had severe periodontitis with complete loss of permanent teeth and skin fragility with thin skin, atrophic scars, and brownish atrophic pretibial plaques. Leg ulcer is not a prominent feature of EDS-VIII. We suggest adding EDS-VIII to the list of rare diseases accounting for chronic leg ulcers, if this case report prompts others to report leg ulcers associated with EDS-VIII.

Progress in nuclear energy. Volume 10

International Nuclear Information System (INIS)

Williams, M.M.R.; McCormick, N.J.

1983-01-01

This book consists of 15 articles written by specialists in the field of atomic energy. A significant portion of this volume is devoted to a special section reporting on the impact of the accident at Three Mile Island on the nuclear power industry. Changes in reactor instrumentation, operator training, and emergency preparedness are discussed in detail. A paper reporting on the effects of the accident on the public's attitude toward nuclear power is included in this section. Contents, abridged: The safety of CO 2 cooled reactor technology. Denaturing fissile materials. Impact of the Three Mile Island accident on the nuclear power industry; changes in the nuclear power industry after TMI; impact of TMI on combustion engineering technical activities. Impact of the accident at Three Mile Island on a NSSS vendor--a Westinghouse perspective; emergency planning and preparedness since Three Mile Island. The impact of TMI upon the public acceptance of nuclear power

Applications of the gas chromatography in the nuclear science and technology

International Nuclear Information System (INIS)

Gasco Sanchez, L.

1972-01-01

This paper is a review on the applications of the gas chromatography in the nuclear science and technology published up to December 1971. Its contents has been classified under the following heads; I) Radiogaschromatography, II) Isotope separation, III) Preparation of labelled molecules, IV) Nuclear fuel cycle, V) Nuclear reactor technology, VI) Irradiation chemistry, VIl) Separation of me tal compounds in gas phase, VIII) Applications of the gas chromatography carried out at the Junta de Energia Nuclear, Spain. Arapter VIII only includes the investigations carried out from January 1969 to December 1971. Previous investigations in this field has been published elsewhere. (Author)

AAV5-Factor VIII Gene Transfer in Severe Hemophilia A.

Science.gov (United States)

Rangarajan, Savita; Walsh, Liron; Lester, Will; Perry, David; Madan, Bella; Laffan, Michael; Yu, Hua; Vettermann, Christian; Pierce, Glenn F; Wong, Wing Y; Pasi, K John

2017-12-28

Patients with hemophilia A rely on exogenous factor VIII to prevent bleeding in joints, soft tissue, and the central nervous system. Although successful gene transfer has been reported in patients with hemophilia B, the large size of the factor VIII coding region has precluded improved outcomes with gene therapy in patients with hemophilia A. We infused a single intravenous dose of a codon-optimized adeno-associated virus serotype 5 (AAV5) vector encoding a B-domain-deleted human factor VIII (AAV5-hFVIII-SQ) in nine men with severe hemophilia A. Participants were enrolled sequentially into one of three dose cohorts (low dose [one participant], intermediate dose [one participant], and high dose [seven participants]) and were followed through 52 weeks. Factor VIII activity levels remained at 3 IU or less per deciliter in the recipients of the low or intermediate dose. In the high-dose cohort, the factor VIII activity level was more than 5 IU per deciliter between weeks 2 and 9 after gene transfer in all seven participants, and the level in six participants increased to a normal value (>50 IU per deciliter) that was maintained at 1 year after receipt of the dose. In the high-dose cohort, the median annualized bleeding rate among participants who had previously received prophylactic therapy decreased from 16 events before the study to 1 event after gene transfer, and factor VIII use for participant-reported bleeding ceased in all the participants in this cohort by week 22. The primary adverse event was an elevation in the serum alanine aminotransferase level to 1.5 times the upper limit of the normal range or less. Progression of preexisting chronic arthropathy in one participant was the only serious adverse event. No neutralizing antibodies to factor VIII were detected. The infusion of AAV5-hFVIII-SQ was associated with the sustained normalization of factor VIII activity level over a period of 1 year in six of seven participants who received a high dose, with

2009 transparency and nuclear safety report. CEA Cadarache. Volumes 1 + 2

International Nuclear Information System (INIS)

2009-01-01

After a general presentation of the Cadarache site and of its nuclear installations, the first volume of this report describes the various measures concerning the site safety (safety organisation, general measures, measures related to various risks, inspections, control of emergency situations, audits and second level control, measures in basic nuclear installations) and radioprotection (organisation, significant facts, dosimeter results). It describes significant events which occurred in relationship with nuclear safety and radioprotection, presents results of measurements of releases and of their impact on the environment (chemical and radiological assessment). Then after a description of measures to limit the volume of stored radioactive wastes and their impact on health and on the environment, tables indicate the nature and quantities of wastes which are stored in the different basic nuclear installations of Cadarache. The second volume proposes the same information for two specific nuclear installations belonging to Areva and located in Cadarache, the INB 32 and 54 (INB stands for basic nuclear installation) for which a significant event occurred on the 6 October 2009. For these installations, release measurements concern gaseous and liquid releases

Blood coagulation factor VIII

Indian Academy of Sciences (India)

Factor VIII (FVIII) functions as a co-factor in the blood coagulation cascade for the proteolytic activation of factor X by factor IXa. Deficiency of FVIII causes hemophilia A, the most commonly inherited bleeding disorder. This review highlights current knowledge on selected aspects of FVIII in which both the scientist and the ...

POWER-GEN '90 conference papers: Volume 7 (Fossil plant performance availability and improvement) and Volume 8 (Nuclear power issues)

International Nuclear Information System (INIS)

Anon.

1990-01-01

This is book 4 of papers presented at the Third International Exhibition and Conference for the Power Generation Industries, December 4-6, 1990. This book contains Volume 7, Fossil Plant Performance Availability and Improvement, and Volume 8, Nuclear Power Issues. The topics of the papers include computer applications in plant operations and maintenance, managing aging plants, plant improvements, plant operations and maintenance, the future of nuclear power, achieving cost effective plant operation, managing nuclear plant aging and license renewal, and the factors affecting a decision to build a new nuclear plant

Nuclear carrier business volume projections, 1980-2000

International Nuclear Information System (INIS)

Lebo, R.G.; McKeown, M.S.; Rhyne, W.R.

1980-05-01

The expected number of shipments of commodities in the nuclear fuel cycle are projected for the years 1980 thru 2000. Projections are made for: yellowcake (U 3 O 8 ); natural, enriched and reprocessed uranium hexafluoride (UF 6 ); uranium dioxide powder (UO 2 ); plutonium dioxide powder (PuO 2 ); fresh UO 2 and mixed oxide (MOX) fuel; spent UO 2 fuel; low-level waste (LLW); transuranic (TRU) waste; high-activity TRU waste; high-level waste (HLW), and cladding hulls. Projections are also made for non-fuel cycle commodities such as defense TRU wastes and institutional wastes, since they also are shipped by the commercial transportation industry. Projections of waste shipments from LWRs are based on the continuation of current volume reduction and solidification techniques now used by the utility industry. Projections are also made based on a 5% per year reduction in LWR waste volume shipped which is assumed to occur as a result of increased implementation of currently available volume reduction systems. This assumption results in a net 64% decrease in the total waste shipped by the year 2000. LWR waste shipment projections, and essentially all other projections for fuel cycle commodities covered in this report, are normalized to BWR and PWR generating capacity projections set forth by the Department of Energy (DOE) in their low-growth projection of April, 1979. Therefore these commodity shipment projections may be altered to comply with future changes in generating capacity projections. Projected shipments of waste from the reprocessing of spent UO 2 fuel are based on waste generation rates proposed by Nuclear Fuels Services, Allied-General Nuclear Services, Exxon Nuclear, and the DOE. Reprocessing is assumed to begin again in 1990, with mixed oxide fresh fuel available for shipment by 1991

Agnostic stacking of intergalactic doublet absorption: measuring the Ne VIII population

Science.gov (United States)

Frank, Stephan; Pieri, Matthew M.; Mathur, Smita; Danforth, Charles W.; Shull, J. Michael

2018-05-01

We present a blind search for doublet intergalactic metal absorption with a method dubbed `agnostic stacking'. Using a forward-modelling framework, we combine this with direct detections in the literature to measure the overall metal population. We apply this novel approach to the search for Ne VIII absorption in a set of 26 high-quality COS spectra. We probe to an unprecedented low limit of log N>12.3 at 0.47≤z ≤1.34 over a path-length Δz = 7.36. This method selects apparent absorption without requiring knowledge of its source. Stacking this mixed population dilutes doublet features in composite spectra in a deterministic manner, allowing us to measure the proportion corresponding to Ne VIII absorption. We stack potential Ne VIII absorption in two regimes: absorption too weak to be significant in direct line studies (12.3 13.7). We do not detect Ne VIII absorption in either regime. Combining our measurements with direct detections, we find that the Ne VIII population is reproduced with a power-law column density distribution function with slope β = -1.86 ^{+0.18 }_{ -0.26} and normalization log f_{13.7} = -13.99 ^{+0.20 }_{ -0.23}, leading to an incidence rate of strong Ne VIII absorbers dn/dz =1.38 ^{+0.97 }_{ -0.82}. We infer a cosmic mass density for Ne VIII gas with 12.3 value significantly lower that than predicted by recent simulations. We translate this density into an estimate of the baryon density Ωb ≈ 1.8 × 10-3, constituting 4 per cent of the total baryonic mass.

Index to Nuclear Safety: a technical progress review by chronology, permuted title, and author, Volume 18 (1) through Volume 22 (6)

International Nuclear Information System (INIS)

Cottrell, W.B.; Passiakos, M.

1982-06-01

This index to Nuclear Safety covers articles published in Nuclear Safety, Volume 18, Number 1 (January-February 1977) through Volume 22, Number 6 (November-December 1981). The index is divided into three section: a chronological list of articles (including abstracts), a permuted-title (KWIC) index, and an author index. Nuclear Safety, a bimonthly technical progress review prepared by the Nuclear Safety Information Center, covers all safety aspects of nuclear power reactors and associated facilities. Over 300 technical articles published in Nuclear Safety in the last 5 years are listed in this index

Index to Nuclear Safety: a technical progress review by chronology, permuted title, and author, Volume 18 (1) through Volume 22 (6)

Energy Technology Data Exchange (ETDEWEB)

Cottrell, W.B.; Passiakos, M.

1982-06-01

This index to Nuclear Safety covers articles published in Nuclear Safety, Volume 18, Number 1 (January-February 1977) through Volume 22, Number 6 (November-December 1981). The index is divided into three section: a chronological list of articles (including abstracts), a permuted-title (KWIC) index, and an author index. Nuclear Safety, a bimonthly technical progress review prepared by the Nuclear Safety Information Center, covers all safety aspects of nuclear power reactors and associated facilities. Over 300 technical articles published in Nuclear Safety in the last 5 years are listed in this index.

Nuclear reactor engineering: Reactor design basics. Fourth edition, Volume One

International Nuclear Information System (INIS)

Glasstone, S.; Sesonske, A.

1994-01-01

This new edition of this classic reference combines broad yet in-depth coverage of nuclear engineering principles with practical descriptions of their application in design and operation of nuclear power plants. Extensively updated, the fourth edition includes new material on reactor safety and risk analysis, regulation, fuel management, waste management, and operational aspects of nuclear power. This volume contains the following: energy from nuclear fission; nuclear reactions and radiations; neutron transport; nuclear design basics; nuclear reactor kinetics and control; radiation protection and shielding; and reactor materials

9th Pacific Basin Nuclear Conference. Nuclear energy, science and technology - Pacific partnership. Proceedings Volume 1

International Nuclear Information System (INIS)

1994-04-01

The theme of the 9th Pacific Basin Nuclear conference held in Sydney from 1-6 May 1994, embraced the use of the atom in energy production and in science and technology. The focus was on selected topics of current and ongoing interest to countries around the Pacific Basin. The two-volume proceedings include both invited and contributed papers. They have been indexed separately. This document, Volume 1 covers the following topics: Pacific partnership; perspectives on nuclear energy, science and technology in Pacific Basin countries; nuclear energy and sustainable development; economics of the power reactors; new power reactor projects; power reactor technology; advanced reactors; radioisotope and radiation technology; biomedical applications

Journal of Undergraduate Research, Volume VIII, 2008

Energy Technology Data Exchange (ETDEWEB)

Stiner, K. S.; Graham, S.; Khan, M.; Dilks, J.; Mayer, D.

2008-01-01

Th e Journal of Undergraduate Research (JUR) provides undergraduate interns the opportunity to publish their scientific innovation and to share their passion for education and research with fellow students and scientists. Fields in which these students worked include: Biology; Chemistry; Computer Science; Engineering; Environmental Science; General Sciences; Materials Sciences; Medical and Health Sciences; Nuclear Sciences; Physics; Science Policy; and Waste Management.

Index to Nuclear Safety: a technical progress review by chrology, permuted title, and author, Volume 11(1) through Volume 20(6)

Energy Technology Data Exchange (ETDEWEB)

Cottrell, W B; Passiakos, M

1980-06-01

This index to Nuclear Safety, a bimonthly technical progress review, covers articles published in Nuclear Safety, Volume II, No. 1 (January-February 1970), through Volume 20, No. 6 (November-December 1979). It is divided into three sections: a chronological list of articles (including abstracts) followed by a permuted-title (KWIC) index and an author index. Nuclear Safety, a bimonthly technical progress review prepared by the Nuclear Safety Information Center (NSIC), covers all safety aspects of nuclear power reactors and associated facilities. Over 600 technical articles published in Nuclear Safety in the last ten years are listed in this index.

The labour ward analgesic service at King Edward VIII Hospital ...

African Journals Online (AJOL)

The labour ward analgesic service at King Edward VIII. Hospital, Durban. D. A. ROCKE, C. C. ROUT, H. D. RUSSELL, S. SINGH. Abstract The provision of analgesic services to the labour ward at King Edward VIII Hospital was studied during a I-week period. Of249 patients, 113 (45%) received no analgesia whatsoever.

Nuclear criticality safety experiments, calculations, and analyses: 1958 to 1982. Volume 1. Lookup tables

International Nuclear Information System (INIS)

Koponen, B.L.; Hampel, V.E.

1982-01-01

This compilation contains 688 complete summaries of papers on nuclear criticality safety as presented at meetings of the American Nuclear Society (ANS). The selected papers contain criticality parameters for fissile materials derived from experiments and calculations, as well as criticality safety analyses for fissile material processing, transport, and storage. The compilation was developed as a component of the Nuclear Criticality Information System (NCIS) now under development at the Lawrence Livermore National Laboratory. The compilation is presented in two volumes: Volume 1 contains a directory to the ANS Transaction volume and page number where each summary was originally published, the author concordance, and the subject concordance derived from the keyphrases in titles. Volume 2 contains - in chronological order - the full-text summaries, reproduced here by permission of the American Nuclear Society from their Transactions, volumes 1-41

Intralesional and metastatic heterogeneity in malignant melanomas demonstrated by stereologic estimates of nuclear volume

DEFF Research Database (Denmark)

Sørensen, Flemming Brandt; Erlandsen, M

1990-01-01

Regional variability of nuclear 3-dimensional size can be estimated objectively using point-sampled intercepts obtained from different, defined zones within individual neoplasms. In the present study, stereologic estimates of the volume-weighted mean nuclear volume, nuclear vv, within peripheral...... on average larger in the peripheral zones of primary melanomas, than nuclear vv in central zones (2p = 6.7 x 10(-4), whereas no zonal differences were demonstrated in metastatic lesions (2p = 0.21). A marked intraindividual variation was demonstrated between primary and corresponding secondary melanomas (2p...... melanomas showed large interindividual variation. This finding emphasizes that unbiased estimates of nuclear vv are robust to regional heterogeneity of nuclear volume and thus suitable for purposes of objective, quantitative malignancy grading of melanomas....

Thermoelectrical properties of the compounds ScM{sup VIII}Sb and YM{sup VIII}Sb (M{sup VIII} = Ni, Pd, Pt)

Energy Technology Data Exchange (ETDEWEB)

Oestreich, J; Probst, U; Richardt, F; Bucher, E [University of Konstanz, PO Box X916, D-78457 Konstanz (Germany)

2003-02-05

The research into new materials with good thermoelectric properties has revealed new compounds consisting of metallic elements (Bando Y, Suemitsu T, Takagi K, Tokushima H, Echizen Y, Katoh K, Umeo K, Maeda Y and Takabatake T 2000 J. Alloys Compounds 313 1-6, Ghelani N, Loo S, Chung D, Sportouch S, Nardi S, Kanatzidis M, Hogan T and Nolas G 2000 Mater. Res. Soc. 626 Z8.6.1). The half-Heusler compound ZrNiSn, in particular, shows promising thermoelectric properties and has been studied by many scientists during recent years (Uher C, Hu S, Yang J, Meisner G P and Morelli D T 1997 Proc. ICT'97: 16th Int. Conf. on Thermoelectrics pp 485-8, Romaka L P, Stadnyk Yu V, Goryn A M, Gorelenko Yu K and Skolozdra R V 1997 Proc. ICT'97: 16th Int. Conf. on Thermoelectrics pp 516-19, Hohl H, Ramirez A P, Goldmann C, Ernst G, Woelfing B and Bucher E 1998 J. Phys.: Condens. Matter 11 1697-709, Oestreich J, Kaefer W, Richardt F, Probst U and Bucher E 1999 Proc. 5th European Workshop on Thermoelectrics pp 192-5). In an effort to find new thermoelectric materials, the half-Heusler compounds of the groups ScM{sup VIII}Sb and YM{sup VIII}Sb (M{sup VIII} = Ni, Pd, Pt) were synthesized by arc melting and the thermoelectric properties were examined by standard characterization methods. Doping experiments showed that it is possible to change the electrical properties of the compounds while retaining the half-Heusler structure. Within the two groups, YPtSb showed the best thermoelectrical properties. At a temperature of 400 K the electrical conductivity of YPtSb is 748{omega}{sup -1} cm{sup -1} and the Seebeck coefficient is 116.3{mu}V K{sup -1}. The thermal conductivity at 400 K extrapolated using the Wiedemann-Franz law is 2.87 W K{sup -1} m{sup -1}. This leads to a dimensionless figure of merit of 0.14.

2007 transparency and nuclear safety report. CEA Cadarache. Volumes 1 + 2

International Nuclear Information System (INIS)

2007-01-01

After a general presentation of the Cadarache site and of its nuclear installations, the first volume of this report describes the various measures concerning the site safety: safety organisation, general measures, measures related to various risks, control of emergency situations, inspections, audits and second level control, measures in basic nuclear installations. It describes the measures concerning the radioprotection on this site: organisation, significant facts, and dose measurement results. It describes significant events which occurred in relationship with nuclear safety and radioprotection, presents results of release measurements and of radiological and chemical assessments of the impact these releases on the environment. The report then describes measures implemented to limit the volume of stored radioactive wastes and also their impact on health and on the environment. It provides a series of tables indicating the nature and quantities of wastes which are stored in the different basic nuclear installations of Cadarache. It reports the recommendations expressed by the CHSCT (committee on hygiene, security and working conditions) after the 2006 report. The second volume proposes the same information for two specific nuclear installations belonging to Areva and located in Cadarache, the INB 32 and 54 (INB stands for basic nuclear installation), for which the significant events occurred on the 13. of March and on the 25. of May 2007. For these installations, release measurements concern gaseous and liquid releases

Nuclear legislation. Analytical study. Regulatory and Institutional framework for nuclear activities in OECD Member countries. Volume I

International Nuclear Information System (INIS)

1983-01-01

This study is part of a series of analytical studies of the major aspects of nuclear legislation in OECD Member countries and is published in two volumes. This Volume I of the study is a revision and an expansion of a 1969 study concerning the organisation and general regime governing nuclear activities. The national studies were prepared, to the extent possible, following a standard plan for all countries to facilitate information retrieval and comparison. (NEA) [fr

New study on the XeVIII spectrum

International Nuclear Information System (INIS)

Gallardo, M.; Raineri, M.; Giuliani, M.; Lagorio, C.; Padilla, S.; Sarmiento, R.; Reyna Almandos, J.G.

2005-01-01

Capillary light sources were used to observe the spectrum of seven-times-ionized xenon, XeVIII, in the 300-6000 A wavelength range. Twenty-eight energy levels belonging to the 5s-9s, 5d-9d, 5g-9g, 7i-10i, 9l, 5p-9p, 4f-9f, 6h-9h and 8k-10k configurations were adjusted and 38 new spectral lines were classified. The XeVIII ionization energy was determined with improved accuracy using the polarization model. The analysis was supported by Hartree-Fock calculations. The weighted oscillator strengths for all the observed spectral lines were also calculated considering the fitted values for the energy parameters

New study on the XeVIII spectrum

Energy Technology Data Exchange (ETDEWEB)

Gallardo, M. [Centro de Investigaciones Opticas (CIOp) Casilla de Correo 124, 1900 La Plata (Argentina)]. E-mail: gallardom@ciop.unlp.edu.ar; Raineri, M. [Centro de Investigaciones Opticas (CIOp) Casilla de Correo 124, 1900 La Plata (Argentina)]. E-mail: monicar@ciop.unlp.edu.ar; Giuliani, M. [Dto. de Fisica, Fac. de C. Exactas y Naturales, Universidad Nacional de Mar del Plata Funes 3350 (7600) Mar del Plata (Argentina); Lagorio, C. [Dto. de Fisica, Fac. de C. Exactas y Naturales, Universidad Nacional de Mar del Plata Funes 3350 (7600) Mar del Plata (Argentina); Padilla, S. [Dto. de Fisica, Fac. de C. Exactas y Naturales, Universidad Nacional de Mar del Plata Funes 3350 (7600) Mar del Plata (Argentina); Sarmiento, R. [Dto. De Fisica, Universidad del Atlantico, A.A 1890 Barranquilla (Colombia); Reyna Almandos, J.G. [Centro de Investigaciones Opticas (CIOp) Casilla de Correo 124, 1900 La Plata (Argentina)]. E-mail: jreyna@ciop.unlp.edu.ar

2005-10-15

Capillary light sources were used to observe the spectrum of seven-times-ionized xenon, XeVIII, in the 300-6000 A wavelength range. Twenty-eight energy levels belonging to the 5s-9s, 5d-9d, 5g-9g, 7i-10i, 9l, 5p-9p, 4f-9f, 6h-9h and 8k-10k configurations were adjusted and 38 new spectral lines were classified. The XeVIII ionization energy was determined with improved accuracy using the polarization model. The analysis was supported by Hartree-Fock calculations. The weighted oscillator strengths for all the observed spectral lines were also calculated considering the fitted values for the energy parameters.

Nuclear fuel technology - Tank calibration and volume determination for nuclear materials accountancy - Part 1: Procedural overview

International Nuclear Information System (INIS)

2007-01-01

Accurate determinations of volume are a fundamental component of any measurement-based system of control and accountability in a facility that processes or stores nuclear materials in liquid form. Volume determinations are typically made with the aid of a calibration or volume measurement equation that relates the response of the tank's measurement system to some independent measure of tank volume. The ultimate purpose of the calibration exercise is to estimate the tank's volume measurement equation (the inverse of the calibration equation), which relates tank volume to measurement system response. The steps carried out to acquire data for estimating the tank's calibration or volume measurement equation are collectively described as the process of tank calibration. This part of ISO 18213 describes procedures for tank calibration and volume determination for nuclear process tanks equipped with pressure-measurement systems for determining liquid content. Specifically, overall guidance is provided for planning a calibration exercise undertaken to obtain the data required for the measurement equation to estimate a tank's volume. The key steps in the procedure are also presented for subsequently using the estimated volume-measurement equation to determine tank liquid volumes. The procedures presented apply specifically to tanks equipped with bubbler probe systems for measuring liquid content. Moreover, these procedures produce reliable results only for clear (i.e. without suspended solids), homogeneous liquids that are at both thermal and static equilibrium. The paper elaborates on scope, physical principles involved, the calibration model, equipment required, a typical tank calibration procedure, calibration planning and pre-calibration activities, and volume determination. A bibliography is provided

Proceedings of the INAC 2007 International nuclear atlantic conference. Nuclear energy and energetic challenges for 21st. century. 15. Brazilian national meeting on reactor physics and thermal hydraulics; 8. Brazilian national meeting on nuclear applications

International Nuclear Information System (INIS)

2007-01-01

Following the success of INAC 2002 and 2005, INAC 2007 has been held with the 15th Meeting on Reactor Physics and Thermal Hydraulics (XV ENFIR) and the 8th Meeting on Nuclear Applications (VIII ENAN). A key goal of these joint meetings is to bring together scientists to exchange the latest research and development (R and D) information in nuclear science and technology. In the INAC 2007 technical program, plenary sessions, such as round table discussions and keynote lectures, has held to present to the general public the recent advances of peaceful nuclear energy usage, reducing the global warming. Besides, INAC 2007 has offered a poster technical session on Management Systems for Nuclear Organizations. The XV ENFIR has covered all aspects of interdisciplinary R and D related to nuclear reactors, and the VIII ENAN has offered a forum for discussion on nuclear applications in industry, geology, agriculture, medicine, biology, environmental sciences always highlighting the social, economical and environmental improvements generated by nuclear techniques. Both ENFIR and ENAN have also organized oral and poster technical sessions

Proceedings of the INAC 2007 International nuclear atlantic conference. Nuclear energy and energetic challenges for 21st. century. 15. Brazilian national meeting on reactor physics and thermal hydraulics; 8. Brazilian national meeting on nuclear applications

Energy Technology Data Exchange (ETDEWEB)

NONE

2007-07-01

Following the success of INAC 2002 and 2005, INAC 2007 has been held with the 15th Meeting on Reactor Physics and Thermal Hydraulics (XV ENFIR) and the 8th Meeting on Nuclear Applications (VIII ENAN). A key goal of these joint meetings is to bring together scientists to exchange the latest research and development (R and D) information in nuclear science and technology. In the INAC 2007 technical program, plenary sessions, such as round table discussions and keynote lectures, has held to present to the general public the recent advances of peaceful nuclear energy usage, reducing the global warming. Besides, INAC 2007 has offered a poster technical session on Management Systems for Nuclear Organizations. The XV ENFIR has covered all aspects of interdisciplinary R and D related to nuclear reactors, and the VIII ENAN has offered a forum for discussion on nuclear applications in industry, geology, agriculture, medicine, biology, environmental sciences always highlighting the social, economical and environmental improvements generated by nuclear techniques. Both ENFIR and ENAN have also organized oral and poster technical sessions.

DNA-index and stereological estimation of nuclear volume in primary and metastatic malignant melanomas

DEFF Research Database (Denmark)

Sørensen, Flemming Brandt; Kristensen, I B; Grymer, F

1990-01-01

The aim of this study was to investigate the relationship between physical nuclear volume and ploidy level in malignant melanomas, and to analyse the heterogeneity of these two parameters among primary and corresponding secondary tumours. Unbiased stereological estimates of nuclear volume can...

Effectiveness of Mind Mapping in English Teaching among VIII Standard Students

Science.gov (United States)

Hallen, D.; Sangeetha, N.

2015-01-01

The aim of the study is to find out the effectiveness of mind mapping technique over conventional method in teaching English at high school level (VIII), in terms of Control and Experimental group. The sample of the study comprised, 60 VIII Standard students in Tiruchendur Taluk. Mind Maps and Achievement Test (Pretest & Posttest) were…

Population pharmacokinetics of recombinant coagulation factor VIII-SingleChain in patients with severe hemophilia A.

Science.gov (United States)

Zhang, Y; Roberts, J; Tortorici, M; Veldman, A; St Ledger, K; Feussner, A; Sidhu, J

2017-06-01

Essentials rVIII-SingleChain is a unique recombinant factor VIII (FVIII) molecule. A population pharmacokinetic model was based on FVIII activity of severe hemophilia A patients. The model was used to simulate factor VIII activity-time profiles for various dosing scenarios. The model supports prolonged dosing of rVIII-SingleChain with intervals of up to twice per week. Background Single-chain recombinant coagulation factor VIII (rVIII-SingleChain) is a unique recombinant coagulation factor VIII molecule. Objectives To: (i) characterize the population pharmacokinetics (PK) of rVIII-SingleChain in patients with severe hemophilia A; (ii) identify correlates of variability in rVIII-SingleChain PK; and (iii) simulate various dosing scenarios of rVIII-SingleChain. Patients/Methods A population PK model was developed, based on FVIII activity levels of 130 patients with severe hemophilia A (n = 91 for ≥ 12-65 years; n = 39 for  85% and > 93% of patients were predicted to maintain FVIII activity level above 1 IU dL -1 , at all times with three-times-weekly dosing (given on days 0, 2, and 4.5) at the lowest (20 IU kg -1 ) and highest (50 IU kg -1 ) doses, respectively. For twice weekly dosing (days 0 and 3.5) of 50 IU kg -1 rVIII-SingleChain, 62-80% of patients across all ages were predicted to maintain a FVIII activity level above 1 IU dL -1 at day 7. Conclusions The population PK model adequately characterized rVIII-SingleChain PK, and the model can be utilized to simulate FVIII activity-time profiles for various dosing scenarios. © 2017 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.

Nuclear reactor engineering: Reactor systems engineering. Fourth edition, Volume Two

International Nuclear Information System (INIS)

Glasstone, S.; Sesonske, A.

1994-01-01

This new edition of this classic reference combines broad yet in-depth coverage of nuclear engineering principles with practical descriptions of their application in the design and operation of nuclear power plants. Extensively updated, the fourth edition includes new materials on reactor safety and risk analysis, regulation, fuel management, waste management and operational aspects of nuclear power. This volume contains the following: the systems concept, design decisions, and information tools; energy transport; reactor fuel management and energy cost considerations; environmental effects of nuclear power and waste management; nuclear reactor safety and regulation; power reactor systems; plant operations; and advanced plants and the future

Stereological estimates of nuclear volume in squamous cell carcinoma of the uterine cervix and its precursors

DEFF Research Database (Denmark)

Sørensen, Flemming Brandt; Bichel, P; Jakobsen, A

1991-01-01

Using modern stereology, this study was carried out to obtain base-line data concerning three-dimensional, mean nuclear size in precancerous and invasive lesions of the uterine cervix. Unbiased estimates of the volume-weighted mean nuclear volume (nuclear vv) were obtained by point-sampling of nu......Using modern stereology, this study was carried out to obtain base-line data concerning three-dimensional, mean nuclear size in precancerous and invasive lesions of the uterine cervix. Unbiased estimates of the volume-weighted mean nuclear volume (nuclear vv) were obtained by point......-sampling of nuclear intercepts in 51 pre-treatment biopsies from patients with invasive squamous cell carcinomas (SCC). Vertical sections from 27 specimens with cervical intraepithelial neoplasia (CIN) grades I through III were also investigated, along with 10 CIN III associated with microinvasion (CIN III + M......). On average, nuclear vv was larger in SCC than in CIN III and CIN III + M together (2 P = 8.9 . 10(-5). A conspicuous overlap of nuclear vv existed between all investigated lesional groups. The reproducibility of estimates of nuclear vv in biopsies with SCC was acceptable (r = 0.85 and r = 0.84 in intra...

10. National Nuclear Science and Technology Congress Proceedings Book, Volume 2

International Nuclear Information System (INIS)

2009-01-01

X. National Nuclear Science and Technologies Congress was held on 6-9 October 2009 in Mugla, Turkey in the course of collaborative organization undertaken by Turkish Atomic Energy Authority, Mugla University and Sitki Kocman Foundation. This second volume of Proceedings Book contains 91 submitted presentations and 51 of them are full texts on applications of basic nuclear sciences, nuclear energy and safety.

Nuclear criticality safety experiments, calculations, and analyses - 1958 to 1982. Volume 2. Summaries. Complilation of papers from the Transactions of the American Nuclear Society

International Nuclear Information System (INIS)

Koponen, B.L.; Hampel, V.E.

1982-01-01

This compilation contains 688 complete summaries of papers on nuclear criticality safety as presented at meetings of the American Nuclear Society (ANS). The selected papers contain criticality parameters for fissile materials derived from experiments and calculations, as well as criticality safety analyses for fissile material processing, transport, and storage. The compilation was developed as a component of the Nuclear Criticality Information System (NCIS) now under development at the Lawrence Livermore National Laboratory. The compilation is presented in two volumes: Volume 1 contains a directory to the ANS Transaction volume and page number where each summary was originally published, the author concordance, and the subject concordance derived from the keyphrases in titles. Volume 2 contains-in chronological order-the full-text summaries, reproduced here by permission of the American Nuclear Society from their Transactions, volumes 1-41

Nuclear criticality safety experiments, calculations, and analyses - 1958 to 1982. Volume 2. Summaries. Complilation of papers from the Transactions of the American Nuclear Society

Energy Technology Data Exchange (ETDEWEB)

Koponen, B.L.; Hampel, V.E.

1982-10-21

This compilation contains 688 complete summaries of papers on nuclear criticality safety as presented at meetings of the American Nuclear Society (ANS). The selected papers contain criticality parameters for fissile materials derived from experiments and calculations, as well as criticality safety analyses for fissile material processing, transport, and storage. The compilation was developed as a component of the Nuclear Criticality Information System (NCIS) now under development at the Lawrence Livermore National Laboratory. The compilation is presented in two volumes: Volume 1 contains a directory to the ANS Transaction volume and page number where each summary was originally published, the author concordance, and the subject concordance derived from the keyphrases in titles. Volume 2 contains-in chronological order-the full-text summaries, reproduced here by permission of the American Nuclear Society from their Transactions, volumes 1-41.

Quark-nuclear hybrid star equation of state with excluded volume effects

Science.gov (United States)

Kaltenborn, Mark Alexander Randolph; Bastian, Niels-Uwe Friedrich; Blaschke, David Bernhard

2017-09-01

A two-phase description of the quark-nuclear matter hybrid equation of state that takes into account the effect of excluded volume in both the hadronic and the quark-matter phases is introduced. The nuclear phase manifests a reduction of the available volume as density increases, leading to a stiffening of the matter. The quark-matter phase displays a reduction of the effective string tension in the confining density functional from available volume contributions. The nuclear equation of state is based upon the relativistic density-functional model DD2 with excluded volume. The quark-matter equation of state is based upon a quasiparticle model derived from a relativistic density-functional approach and will be discussed in greater detail. The interactions are decomposed into mean scalar and vector components. The scalar interaction is motivated by a string potential between quarks, whereas the vector interaction potential is motivated by higher-order interactions of quarks leading to an increased stiffening at high densities. As an application, we consider matter under compact star constraints of electric neutrality and β equilibrium. We obtain mass-radius relations for hybrid stars that form a third family, disconnected from the purely hadronic star branch, and fulfill the 2 M⊙ constraint.

Classification of tubulo-papillary renal cortical tumours using estimates of nuclear volume

DEFF Research Database (Denmark)

Brooks, B; Sørensen, Flemming Brandt; Olsen, S

1993-01-01

The classification of renal cortical tumours is problematic, with no clear division of benign from malignant tumours. Unbiased stereological estimates of volume-weighted nuclear volume (nuclear vv) were obtained by point sampling of nuclear intercepts in a retrospective study of 36 variably sized...... = 241 microns 3) and 15 tumours classified as renal cell carcinomas with diameters > 3 cm, or aggressive histological pattern (average nuclear vv = 229 microns 3) (2p = 0.68). In this subtype of renal cortical tumours, estimates of nuclear vv do not support the historical convention of using a 3 cm...... tumour diameter as the dividing line between adenomas and carcinomas, but support the theory of a single group of tumours. As most of the truly incidental renal cortical tumours are less than 1 cm in diameter, this limit could be considered. Such small benign cortical nodules have never been reported...

Niels Bohr collected works, volume 9: Nuclear physics (1929-1952)

International Nuclear Information System (INIS)

Peierls, R.

1985-01-01

This volume deals with Bohr's work on nuclear physics which began in the pre-1932 days with his thinking deeply, but inconclusively about the seeming contradictions then presented by the evidence about the nucleus. In 1936 Bohr recognized and described the insights provided by neutron scattering experiments and the excitement of this new understanding and its extension and consolidation occupied much of the subsequent years. In 1939 he was again first in understanding the essential features of the newly discovered phenomenon of fission, applying successfully the point of view of nuclear reactions which he had developed over the past three years. Later, in 1949-50, he was impressed by the success of the nuclear shell model, which on the face of it seemed hard to reconcile with the picture of the closely interacting nucleons which he had pioneered in 1936 and he put much effort into clarifying this paradox. As in earlier volumes the published papers are supported by appropriate selections from unpublished notes and drafts, and by relevant correspondence. CONTENTS: Foreword. Part I: Papers and Manuscripts Related to Nuclear Physics. Part II: Selected Correspondence (1929-1949). Inventory of Relevant Manuscripts in the Niels Bohr Archive. Index

Acquired high titre factor VIII inhibitor with underlying polyarteritis nodosa.

Science.gov (United States)

Snowden, J A; Hutchings, M; Spearing, R; Patton, W N

1997-05-01

We here present the case of a 70-year-old woman referred to our unit for investigation of bleeding. Investigations confirmed a high titre acquired Factor VIII inhibitor. In association there was relapse of systemic illness associated with anti-neutrophil cytoplasmic antibodies (atypical pattern) for which she had been treated five years previously. Immunosuppression was attempted, but it failed to have an impact both on the inhibitor titre and on the underlying disorder. The patient died from multi-organ failure and massive chest hemorrhage. Post-mortem showed necrotizing vasculitis of medium sized vessels at several sites, including the kidney, consistent with a diagnosis of polyarteritis nodosa. Although it is well recognised that Factor VIII inhibitors are found in conjunction with autoimmune disorders, this case is significant in that it is the first associated with histologically proven polyarteritis nodosa type vasculitis. The case illustrates the difficulties in the investigation and management of patients with acquired high titre Factor VIII inhibitors.

Chromogenic Factor VIII Assays for Improved Diagnosis of Hemophilia A.

Science.gov (United States)

Rodgers, Susan; Duncan, Elizabeth

2017-01-01

Hemophilia A is an inherited bleeding disorder caused by a reduced level of factor VIII coagulant activity (FVIII:C) in blood. Bleeding episodes may occur spontaneously in the severe form of hemophilia or after trauma in the milder forms. It is important that patients are diagnosed correctly, which includes placing them into the correct severity category of the disorder so that appropriate treatment can be given. Diagnosis is made by determination of the amount of FVIII:C in the blood, usually using a one-stage factor VIII:C assay. However, approximately one third of patients with mild or moderate hemophilia will have much lower results by the chromogenic assay, with some of them having normal results by the one-stage assay. The chromogenic factor VIII assay is used in some specialized hemophilia reference centers and is recommended for the diagnosis of mild hemophilia A, as this assay is considered to better reflect the severity status of hemophilia patients than the one-stage assay.

Type VIII collagen is elevated in diseases associated with angiogenesis and vascular remodeling

DEFF Research Database (Denmark)

Hansen, N. U. B.; Willumsen, N.; Bülow Sand, Jannie Marie

2016-01-01

Objectives Type VIII collagen is involved in angiogenesis and remodeling of arteries. We hypothesized that type VIII collagen was upregulated in diseases associated with vascular remodeling, e.g. pulmonary fibrosis and cancer. In this paper we present the development and validation of a competitive...

The F309S mutation increases factor VIII secretion in human cell line

Directory of Open Access Journals (Sweden)

Daianne Maciely Carvalho Fantacini

2016-06-01

Full Text Available ABSTRACT OBJECTIVES: The capacity of a human cell line to secrete recombinant factor VIII with a F309S point mutation was investigated, as was the effect of the addition of chemical chaperones (betaine and sodium-4-phenylbutyrate on the secretion of factor VIII. METHODS: This work used a vector with a F309S mutation in the A1 domain to investigate FVIII production in the HEK 293 human cell line. Factor VIII activity was measured by chromogenic assay. Furthermore, the effects of chemical drugs on the culture were evaluated. RESULTS: The addition of the F309S mutation to a previously described FVIII variant increased FVIII secretion by 4.5 fold. Moreover, the addition of betaine or sodium-4-phenylbutyrate increased the secretion rate of FVIIIΔB proteins in HEK 293 cells, but the same effect was not seen for FVIIIΔB-F309S indicating that all the recombinant protein produced had been efficiently secreted. CONCLUSION: Bioengineering factor VIII expressed in human cells may lead to an efficient production of recombinant factor VIII and contribute toward low-cost coagulation factor replacement therapy for hemophilia A. FVIII-F309S produced in human cells can be effective in vivo.

Myosin VIII regulates protonemal patterning and developmental timing in the moss Physcomitrella patens.

Science.gov (United States)

Wu, Shu-Zon; Ritchie, Julie A; Pan, Ai-Hong; Quatrano, Ralph S; Bezanilla, Magdalena

2011-09-01

Plants have two classes of myosins. While recent work has focused on class XI myosins showing that myosin XI is responsible for organelle motility and cytoplasmic streaming, much less is known about the role of myosin VIII in plant growth and development. We have used a combination of RNAi and insertional knockouts to probe myosin VIII function in the moss Physcomitrella patens. We isolated Δmyo8ABCDE plants demonstrating that myosin VIII is not required for plant viability. However, myosin VIII mutants are smaller than wild-type plants in part due to a defect in cell size. Additionally, Δmyo8ABCDE plants produce more side branches and form gametophores much earlier than wild-type plants. In the absence of nutrient media, Δmyo8ABCDE plants exhibit significant protonemal patterning defects, including highly curved protonemal filaments, morphologically defective side branches, as well as an increase in the number of branches. Exogenous auxin partially rescues protonemal defects in Δmyo8ABCDE plants grown in the absence of nutrients. This result, together with defects in protonemal branching, smaller caulonemal cells, and accelerated development in the Δmyo8ABCDE plants, suggests that myosin VIII is involved in hormone homeostasis in P. patens.

Specific membrane binding of factor VIII is mediated by O-phospho-L-serine, a moiety of phosphatidylserine.

Science.gov (United States)

Gilbert, G E; Drinkwater, D

1993-09-21

Phosphatidylserine, a negatively charged lipid, is exposed on the platelet membrane following cell stimulation, correlating with the expression of factor VIII receptors. We have explored the importance of the negative electrostatic potential of phosphatidylserine vs chemical moieties of phosphatidylserine for specific membrane binding of factor VIII. Fluorescein-labeled factor VIII bound to membranes containing 15% phosphatidic acid, a negatively charged phospholipid, with low affinity compared to phosphatidylserine-containing membranes. Binding was not specific as it was inhibited by other proteins in plasma. Factor VIII bound to membranes containing 10% phosphatidylserine in spite of a varying net charge provided by 0-15% stearylamine, a positively charged lipid. The soluble phosphatidylserine moiety, O-phospho-L-serine, inhibited factor VIII binding to phosphatidylserine-containing membranes with a Ki of 20 mM, but the stereoisomer, O-phospho-D-serine, was 5-fold less effective. Furthermore, binding of factor VIII to membranes containing synthetic phosphatidyl-D-serine was 5-fold less than binding to membranes containing phosphatidyl-L-serine. Membranes containing synthetic phosphatidyl-L-homoserine, differing from phosphatidylserine by a single methylene, supported high-affinity binding, but it was not specific as factor VIII was displaced by other plasma proteins. O-Phospho-L-serine also inhibited the binding of factor VIII to platelet-derived microparticles with a Ki of 20 mM, and the stereoisomer was 4-fold less effective. These results indicate that membrane binding of factor VIII is mediated by a stereoselective recognition O-phospho-L-serine of phosphatidylserine and that negative electrostatic potential is of lesser importance.

VIII Olimpíada Brasileira de Astronomia e Astronáutica

Science.gov (United States)

Garcia Canalle, João Batista; Villas da Rocha, Jaime Fernando; Wuensche de Souza, Carlos Alexandre; Pereira Ortiz, Roberto; Aguilera, Nuricel Villalonga; Padilha, Maria De Fátima Catta Preta; Pessoa Filho, José Bezerra; Soares Rodrigues, Ivette Maria

2007-07-01

Neste trabalho apresentamos as motivações pelas quais organizamos, em conjunto, pela primeira vez, a Olimpíada Brasileira de Astronomia incluindo a Astronáutica, em colaboração com a Agência Espacial Brasileira. Esta ampliação contribuiu para atrair ainda mais alunos, professores, escolas e patrocinadores para participarem desta Olimpíada. Em 2005 participaram da VIII Olimpíada Brasileira de Astronomia e Astronáutica (VIII OBA) 187.726 alunos distribuídos por 3.229 escolas, pertencentes a todos os estados brasileiros, incluindo o Distrito Federal. O crescimento em número de alunos participantes foi 52,4% maior do que em 2004. Em abril de 2005 organizamos, em Itapecerica da Serra, SP, um curso para os 50 alunos previamente selecionados e participantes da VII OBA e ao final selecionamos, dentre eles, uma equipe de 5 alunos, os quais representaram o Brasil na X Olimpíada Internacional de Astronomia, na China, em outubro de 2005. Ganhamos, pela primeira vez, uma medalha de ouro naquele evento. Em Agosto de 2005, organizamos a VIII Escola de Agosto para 50 alunos e respectivos professores, em Águas de Lindóia, SP, juntamente com a XXXI reunião anual da Sociedade Astronômica Brasileira (SAB). Em novembro de 2005 realizamos a I Jornada Espacial, em São José dos Campos, com 22 alunos e 22 professores selecionados dentre os participantes que melhores resultados obtiveram nas questões de Astronáutica da VIII OBA. Neste trabalho detalhamos os resultados da VIII OBA bem como as ações subseqüentes.

Analysis of mutations in the entire coding sequence of the factor VIII gene

Energy Technology Data Exchange (ETDEWEB)

Bidichadani, S.I.; Lanyon, W.G.; Connor, J.M. [Glascow Univ. (United Kingdom)] [and others

1994-09-01

Hemophilia A is a common X-linked recessive disorder of bleeding caused by deleterious mutations in the gene for clotting factor VIII. The large size of the factor VIII gene, the high frequency of de novo mutations and its tissue-specific expression complicate the detection of mutations. We have used a combination of RT-PCR of ectopic factor VIII transcripts and genomic DNA-PCRs to amplify the entire essential sequence of the factor VIII gene. This is followed by chemical mismatch cleavage analysis and direct sequencing in order to facilitate a comprehensive search for mutations. We describe the characterization of nine potentially pathogenic mutations, six of which are novel. In each case, a correlation of the genotype with the observed phenotype is presented. In order to evaluate the pathogenicity of the five missense mutations detected, we have analyzed them for evolutionary sequence conservation and for their involvement of sequence motifs catalogued in the PROSITE database of protein sites and patterns.

NJOY nuclear data processing system. Volume IV. The ERRORR and COVR modules

International Nuclear Information System (INIS)

Muir, D.W.; MacFarlane, R.E.

1985-12-01

The NJOY nuclear data processing system is a comprehensive computer code package for producing cross sections and related nuclear parameters from ENDF/B evaluated nuclear data. This volume provides detailed descriptions of the NJOY modules ERRORR and COVR, which are concerned with the covariances (uncertainties and correlations) of multigroup cross sections and fission neutron yield (anti nu) values. 17 refs

The vestibulocochlear nerve (VIII).

Science.gov (United States)

Benoudiba, F; Toulgoat, F; Sarrazin, J-L

2013-10-01

The vestibulocochlear nerve (8th cranial nerve) is a sensory nerve. It is made up of two nerves, the cochlear, which transmits sound and the vestibular which controls balance. It is an intracranial nerve which runs from the sensory receptors in the internal ear to the brain stem nuclei and finally to the auditory areas: the post-central gyrus and superior temporal auditory cortex. The most common lesions responsible for damage to VIII are vestibular Schwannomas. This report reviews the anatomy and various investigations of the nerve. Copyright © 2013. Published by Elsevier Masson SAS.

Organizational analysis and safety for utilities with nuclear power plants: perspectives for organizational assessment. Volume 2

International Nuclear Information System (INIS)

Osborn, R.N.; Olson, J.; Sommers, P.E.

1983-08-01

This two-volume report presents the results of initial research on the feasibility of applying organizational factors in nuclear power plant (NPP) safety assessment. Volume 1 of this report contains an overview of the literature, a discussion of available safety indicators, and a series of recommendations for more systematically incorporating organizational analysis into investigations of nuclear power plant safety. The six chapters of this volume discuss the major elements in our general approach to safety in the nuclear industry. The chapters include information on organizational design and safety; organizational governance; utility environment and safety related outcomes; assessments by selected federal agencies; review of data sources in the nuclear power industry; and existing safety indicators

Management of Large Volumes of Waste Arising in a Nuclear or Radiological Emergency

International Nuclear Information System (INIS)

2017-10-01

This publication, prepared in light of the IAEA Action Plan on Nuclear Safety developed after the accident at the Fukushima Daiichi nuclear power plant, addresses the management of large volumes of radioactive waste arising in a nuclear or radiological emergency, as part of overall emergency preparedness. The management of large volumes of waste will be one of many efforts to be dealt with to allow recovery of affected areas, to support return of evacuated or relocated populations and preparations for normal social and economic activities, and/or to mitigate additional environmental impacts. The publication is intended to be of use to national planners and policy makers, facility and programme managers, and other professionals responsible for developing and implementing national plans and strategies to manage radioactive waste arising from nuclear or radiological emergencies.

Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume VI. Safety and environmental considerations for licensing

International Nuclear Information System (INIS)

1979-12-01

Volume 6 of the Nonproliferation Alternative Systems Assessment Program report addresses safety and environmental considerations in licensing the principal alternative nuclear reactors and fuel cycles in the United States for large-scale commercial nuclear power plants. In addition, this volume examines the safety and environmental considerations for licensing fuel service centers. These centers, which have been proposed for controlling sensitive fuel-cycle facilities and special nuclear materials, would contain a combination of such facilities as reprocessing plants, fabrication plants, and reactors. For this analysis, two fuel service center concepts were selected - one with power-generating capability and one without. This volume also provides estimates of the time required for development of large-scale commercial reactor systems to reach the construction permit application stage and for fuel-cycle facilities to reach the operating license application stage, which is a measure of the relative technical status of alternative nuclear systems

Proceedings of the 21st DOE/NRC nuclear air cleaning conference; Volume 2, Sessions 9--16

Energy Technology Data Exchange (ETDEWEB)

First, M.W. [ed.] [Harvard Univ., Boston, MA (United States). Harvard Air Cleaning Lab.

1991-02-01

The 21st meeting of the Department of Energy/Nuclear Regulatory Commission (DOE/NRC) Nuclear Air Cleaning Conference was held in San Diego, CA on August 13--16, 1990. The proceedings have been published as a two volume set. Volume 2 contains sessions covering adsorbents, nuclear codes and standards, modelling, filters, safety, containment venting and a review of nuclear air cleaning programs around the world. Also included is the list of attendees and an index of authors and speakers. (MHB)

Nuclear powerplant standardization: light water reactors. Volume 2. Appendixes

International Nuclear Information System (INIS)

1981-06-01

This volume contains working papers written for OTA to assist in preparation of the report, NUCLEAR POWERPLANT STANDARDIZATION: LIGHT WATER REACTORS. Included in the appendixes are the following: the current state of standardization, an application of the principles of the Naval Reactors Program to commercial reactors; the NRC and standardization, impacts of nuclear powerplant standardization on public health and safety, descriptions of current control room designs and Duke Power's letter, Admiral Rickover's testimony, a history of standardization in the NRC, and details on the impact of standardization on public health and safety

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.7--Nuclear electronics and nuclear detection technology sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 57 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the seventh one, the content is about Nuclear electronics and nuclear detection technology sub-volume

Manufacture of sockets of volume compensators in nuclear power plants

International Nuclear Information System (INIS)

Andreev, V.P.; Tshekotilo, L.V.; Shevtshenko, N.T.; Sevruk, A.N.; Wolacek, W.J.; Irsicek, L.; Vrbensky, J.

1982-01-01

Experience is reported with regard to electroslag casting of sockets of volume compensators or steam separators used in nuclear power plants. According to the method the raw pieces are casted directly at the surface of the enclosures

Igor Zabel 14. VIII 1958 - 23. VII 2005

Index Scriptorium Estoniae

2005-01-01

Igor Zabel oli Ida-Euroopa tuntumaid kunstiteoreetikuid ja kuraatoreid. Töötas 1986. aastast Ljubljana moodsa kunsti muuseumi kuraatorina. 9. VIII avatakse seal viimane I. Zabeli kureeritud näitus "Territories, Identities, Nets-Slovene Art 1995-2005"

Home therapy with continuous infusion of factor VIII after minor surgery or serious haemorrhage.

Science.gov (United States)

Varon, D; Schulman, S; Bashari, D; Martinowitz, U

1996-10-01

Administration of factor VIII (F VIII) concentrates by continuous infusion is now routinely used at several haemophilia centers but almost exclusively for hospitalized patients. We evaluated various aspects of home therapy with continuous infusion of an immunoaffinity purified F VIII concentrate (Monoclate P®, Armour) in patients who would normally have been treated with high doses in bolus injections or with continuous infusion as in-patients. Twenty haemophilia A patients, eight after minor surgery and 12 for serious haemorrhage, received continuous infusion with undiluted F VIII by a minipump for a mean of 0.9 days in the hospital, followed by 3.3 days at home. Infusion bags were exchanged every 2.5 days. No haemorrhagic complications occurred, and five haemorrhages that had been resistant to treatment with bolus injections responded promptly to the continuous infusion. There were no technical problems and patient compliance and acceptance was good. We find this mode of therapy safe, efficacious and convenient for the patients as well as for the staff.

Organizational analysis and safety for utilities with nuclear power plants: an organizational overview. Volume 1

International Nuclear Information System (INIS)

Osborn, R.N.; Olson, J.; Sommers, P.E.; McLaughlin, S.D.; Jackson, M.S.; Scott, W.G.; Connor, P.E.

1983-08-01

This two-volume report presents the results of initial research on the feasibility of applying organizational factors in nuclear power plant (NPP) safety assessment. A model is introduced for the purposes of organizing the literature review and showing key relationships among identified organizational factors and nuclear power plant safety. Volume I of this report contains an overview of the literature, a discussion of available safety indicators, and a series of recommendations for more systematically incorporating organizational analysis into investigations of nuclear power plant safety

Base excision repair efficiency and mechanism in nuclear extracts are influenced by the ratio between volume of nuclear extraction buffer and nuclei—Implications for comparative studies

International Nuclear Information System (INIS)

Akbari, Mansour; Krokan, Hans E.

2012-01-01

Highlights: • We examine effect of volume of extraction buffer relative to volume of isolated nuclei on repair activity of nuclear extract. • Base excision repair activity of nuclear extracts prepared from the same batch and number of nuclei varies inversely with the volume of nuclear extraction buffer. • Effect of the volume of extraction buffer on BER activity of nuclear extracts can only be partially reversed after concentration of the more diluted extract by ultrafiltration. - Abstract: The base excision repair (BER) pathway corrects many different DNA base lesions and is important for genomic stability. The mechanism of BER cannot easily be investigated in intact cells and therefore in vitro methods that reflect the in vivo processes are in high demand. Reconstitution of BER using purified proteins essentially mirror properties of the proteins used, and does not necessarily reflect the mechanism as it occurs in the cell. Nuclear extracts from cultured cells have the capacity to carry out complete BER and can give important information on the mechanism. Furthermore, candidate proteins in extracts can be inhibited or depleted in a controlled way, making defined extracts an important source for mechanistic studies. The major drawback is that there is no standardized method of preparing nuclear extract for BER studies, and it does not appear to be a topic given much attention. Here we have examined BER activity of nuclear cell extracts from HeLa cells, using as substrate a circular DNA molecule with either uracil or an AP-site in a defined position. We show that BER activity of nuclear extracts from the same batch of cells varies inversely with the volume of nuclear extraction buffer relative to nuclei volume, in spite of identical protein concentrations in the BER assay mixture. Surprisingly, the uracil–DNA glycosylase activity (mainly UNG2), but not amount of UNG2, also correlated negatively with the volume of extraction buffer. These studies demonstrate

Factor VIII gene (F8) mutation and risk of inhibitor development in nonsevere hemophilia a

NARCIS (Netherlands)

C.L. Eckhardt (Corien); A.S. van Velzen (Alice); M.A.D. Peters (Marjolein); J. Astermark (Jan); P.P. Brons; G. Castaman (Giancarlo); M.H. Cnossen (Marjon); N. Dors (N.); C. Escuriola-Ettingshausen (Carmen); K. Hamulyák (K.); D.P. Hart (Daniel); C.R.M. Hay (Charles R.); S. Haya (Saturnino); W.L. van Heerde; C. Hermans (Cédric); M. Holmström (Margareta); V. Jimenez-Yuste (Victor); R.D. Keenan (Russell); R. Klamroth (Robert); B.A.P. Laros-Van Gorkom (Britta); F.W.G. Leebeek (Frank); R. Liesner (Ri); A. Mäkipernaa (Anne); C. Male (Christoph); E.P. Mauser-Bunschoten (Eveline); M.G. Mazzucconi (Maria); S. McRae (Simon); K. Meijer (K.); M. Mitchell (Michael); M. Morfini (Massimo); M.R. Nijziel (Marten); J. Oldenburg (Jan); K. Peerlinck; P. Petrini (Pia); H. Platokouki (Helena); S.E. Reitter-Pfoertner (Sylvia); E. Santagostino (Elena); P. Schinco (Piercarla); F.J.W. Smiers (Frans); K.D. Siegmund (Kimberly); A. Tagliaferri (Annarita); T.T. Yee (Thynn); P.W. Kamphuisen (Pieter Willem); J.G. van der Bom (Anske); K. Fijnvandraat

2013-01-01

textabstractNeutralizing antibodies (inhibitors) toward factor VIII form a severe complication in nonsevere hemophilia A, profoundly aggravating the bleeding pattern. Identification of high-risk patients is hampered by lack of data that take exposure days to therapeutic factor VIII concentrates into

Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume VI. Safety and environmental considerations for licensing

International Nuclear Information System (INIS)

1980-06-01

This volume of the Nonproliferation Alternative Systems Assessment Program report addresses safety and environmental considerations in licensing the principal alternative nuclear reactors and fuel cycles in the United States for large-scale commercial nuclear power plants. In addition, this volume examines the safety and environmental considerations for licensing fuel service centers. These centers, which have been proposed for controlling sensitive fuel-cycle facilities and special nuclear materials, would contain a combination of such facilities as reprocessing plants, fabrication plants, and reactors. For this analysis, two fuel service center concepts were selected - one with power - generating capability and one without

Characterization of five partial deletions of the factor VIII gene

International Nuclear Information System (INIS)

Youssoufian, H.; Antonarakis, S.E.; Aronis, S.; Tsiftis, G.; Phillips, D.G.; Kazazian, H.H. Jr.

1987-01-01

Hemophilia A is an X-linked disorder of coagulation caused by a deficiency of factor VIII. By using cloned DNA probes, the authors have characterized the following five different partial deletions of the factor VIII gene from a panel of 83 patients with hemophilia A: (i) a 7-kilobase (kb) deletion that eliminates exon 6; (ii) a 2.5-kb deletion that eliminates 5' sequences of exon 14; (iii) a deletion of at least 7 kb that eliminates exons 24 and 25; (iv) a deletion of at least 16 kb that eliminates exons 23-25; and (v) a 5.5-kb deletion that eliminates exon 22. The first four deletions are associated with severe hemophilia A. By contrast, the last deletion is associated with moderate disease, possibly because of in-frame splicing from adjacent exons. None of those patients with partial gene deletions had circulating inhibitors to factor VIII. One deletion occurred de novo in a germ cell of the maternal grandmother, while a second deletion occurred in a germ cell of the maternal grandfather. These observations demonstrate that de novo deletions of X-linked genes can occur in either male or female gametes

World Energy Data System (WENDS). Volume X. Nuclear facility profiles, PO--ZA

International Nuclear Information System (INIS)

1979-06-01

In this compendium each profile of a nuclear facility is a capsule summary of pertinent facts regarding that particular installation. The facilities described include the entire fuel cycle in the broadest sense, encompassing resource recovery through waste management. Power plants and all US facilities have been excluded. To facilitate comparison the profiles have been recorded in a standard format. Because of the breadth of the undertaking some data fields do not apply to the establishment under discussion and accordingly are blank. The set of nuclear facility profiles occupies four volumes; the profiles are ordered by country name, and then by facility code. Each nuclear facility profile volume contains two complete indexes to the information. The first index aggregates the facilities alphabetically by country. It is further organized by category of facility, and then by the four-character facility code. It provides a quick summary of the nuclear energy capability or interest in each country and also an identifier, the facility code, which can be used to access the information contained in the profile

World Energy Data System (WENDS). Volume IX. Nuclear facility profiles, IN--PL

International Nuclear Information System (INIS)

1979-06-01

In this compendium each profile of a nuclear facility is a capsule summary of pertinent facts regarding that particular installation. The facilities described include the entire fuel cycle in the broadest sense, encompassing resource recovery through waste management. Power plants and all US facilities have been excluded. To facilitate comparison the profiles have been recorded in a standard format. Because of the breadth of the undertaking some data fields do not apply to the establishment under discussion and accordingly are blank. The set of nuclear facility profiles occupies four volumes; the profiles are ordered by country name, and then by facility code. Each nuclear facility profile volume contains two complete indexes to the information. The first index aggregates the facilities alphabetically by country. It is further organized by category of facility, and then by the four-character facility code. It provides a quick summary of the nuclear energy capability or interest in each country and also an identifier, the facility code, which can be used to access the information contained in the profile

World Energy Data System (WENDS). Volume VII. Nuclear facility profiles, AG--CH

International Nuclear Information System (INIS)

1979-06-01

In this compendium each profile of a nuclear facility is a capsule summary of pertinent facts regarding that particular installation. The facilities described include the entire fuel cycle in the broadest sense, encompassing resource recovery through waste management. Power plants and all US facilities have been excluded. To facilitate comparison the profiles have been recorded in a standard format. Because of the breadth of the undertaking some data fields do not apply to the establishment under discussion and accordingly are blank. The set of nuclear facility profiles occupies four volumes; the profiles are ordered by country name, and then by facility code. Each nuclear facility profile volume contains two complete indexes to the information. The first index aggregates the facilities alphabetically by country. It is further organized by category of facility, and then by the four-character facility code. It provides a quick summary of the nuclear energy capability or interest in each country and also an identifier, the facility code, which can be used to access the information contained in the profile

Modifications to LLNL Plutonium Packaging Systems (PuPS) to achieve ASME VIII UW-13.2(d) Requirements for the DOE Standard 3013-00 Outer Can Weld

International Nuclear Information System (INIS)

Riley, D; Dodson, K

2001-01-01

The Lawrence Livermore National Laboratory (LLNL) Plutonium Packaging System (PuPS) prepares packages to meet the DOE Standard 3013 (Reference 1). The PuPS equipment was supplied by the British Nuclear Fuels Limited (BNFL). The DOE Standard 3013 requires that the welding of the Outer Can meets ASME Section VIII Division 1 (Reference 2). ASME Section VIII references to ASME Section IX (Reference 3) for most of the welding requirements, but UW-13.2 (d) of Section VIII requires a certain depth and width of the weld. In this document the UW-13.2(d) requirement is described as the (a+b)/2t s ratio. This ratio has to be greater than or equal to one to meet the requirements of UW-13.2(d). The Outer Can welds had not been meeting this requirement. Three methods are being followed to resolve this issue: (1) Modify the welding parameters to achieve the requirement, (2) Submit a weld case to ASME that changes the UW-13.2(d) requirement for their review and approval, and (3) Change the requirements in the DOE-STD-3013. Each of these methods are being pursued. This report addresses how the first method was addressed for the LLNL PuPS. The experimental work involved adjusting the Outer Can rotational speed and the power applied to the can. These adjustments resulted in being able to achieve the ASME VIII, UW-13.2(d) requirement

Evaluation of the integrity of reactor vessels designed to ASME Code, Sections I and/or VIII

International Nuclear Information System (INIS)

Hoge, K.G.

1976-01-01

A documented review of nuclear reactor pressure vessels designed to ASME Code, Sections I and/or VIII is made. The review is primarily concerned with the design specifications and quality assurance programs utilized for the reactor vessel construction and the status of power plant material surveillance programs, pressure-temperature operating limits, and inservice inspection programs. The following ten reactor vessels for light-water power reactors are covered in the report: Indian Point Unit No. 1, Dresden Unit No. 1, Yankee Rowe, Humboldt Bay Unit No. 3, Big Rock Point, San Onofre Unit No. 1, Connecticut Yankee, Oyster Creek, Nine Mile Point Unit No. 1, and La Crosse

Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex

Energy Technology Data Exchange (ETDEWEB)

Ngo, J.C.; Huang, M.; Roth, D.A.; Furie, B.C.; Furie, B. (Wyeth); (MBL)

2008-06-03

Factor VIII is a procofactor that plays a critical role in blood coagulation, and is missing or defective in hemophilia A. We determined the X-ray crystal structure of B domain-deleted human factor VIII. This protein is composed of five globular domains and contains one Ca{sup 2+} and two Cu{sup 2+} ions. The three homologous A domains form a triangular heterotrimer where the A1 and A3 domains serve as the base and interact with the C2 and C1 domains, respectively. The structurally homologous C1 and C2 domains reveal membrane binding features. Based on biochemical studies, a model of the factor IXa-factor VIIIa complex was constructed by in silico docking. Factor IXa wraps across the side of factor VIII, and an extended interface spans the factor VIII heavy and light chains. This model provides insight into the activation of factor VIII and the interaction of factor VIIIa with factor IXa on the membrane surface.

Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex

Energy Technology Data Exchange (ETDEWEB)

Chi Ki Ngo,J.; Huang, M.; Roth, D.; Furie, B.; Furie, B.

2008-01-01

Factor VIII is a procofactor that plays a critical role in blood coagulation, and is missing or defective in hemophilia A. We determined the X-ray crystal structure of B domain-deleted human factor VIII. This protein is composed of five globular domains and contains one Ca(2+) and two Cu(2+) ions. The three homologous A domains form a triangular heterotrimer where the A1 and A3 domains serve as the base and interact with the C2 and C1 domains, respectively. The structurally homologous C1 and C2 domains reveal membrane binding features. Based on biochemical studies, a model of the factor IXa-factor VIIIa complex was constructed by in silico docking. Factor IXa wraps across the side of factor VIII, and an extended interface spans the factor VIII heavy and light chains. This model provides insight into the activation of factor VIII and the interaction of factor VIIIa with factor IXa on the membrane surface.

10. National Nuclear Science and Technologies Congress Proceedings Full Texts Volume 1

International Nuclear Information System (INIS)

2009-01-01

X. National Nuclear Science and Technologies Congress was held on 6-9 October 2009 in Mugla, Turkey in the course of collaborative organization undertaken by Turkish Atomic Energy Authority, Mugla University and Sitki Kocman Foundation. This first volume of Proceedings Book contains 75 submitted presentations and 36 of them are full texts on applications of nuclear techniques.

Nuclear Dynamics Consequence Analysis (NDCA) for the Disposal of Spent Nuclear Fuel in an Underground Geologic Repository - Volume 3: Appendices

International Nuclear Information System (INIS)

Taylor, L.L.; Wilson, J.R.; Sanchez, L.C.; Aguilar, R.; Trellue, H.R.; Cochrane, K.; Rath, J.S.

1998-01-01

The United States Department of Energy Office of Environmental Management's (DOE/EM's) National Spent Nuclear Fuel Program (NSNFP), through a collaboration between Sandia National Laboratories (SNL) and Idaho National Engineering and Environmental Laboratory (INEEL), is conducting a systematic Nuclear Dynamics Consequence Analysis (NDCA) of the disposal of SNFs in an underground geologic repository sited in unsaturated tuff. This analysis is intended to provide interim guidance to the DOE for the management of the SNF while they prepare for final compliance evaluation. This report presents results from a Nuclear Dynamics Consequence Analysis (NDCA) that examined the potential consequences and risks of criticality during the long-term disposal of spent nuclear fuel owned by DOE-EM. This analysis investigated the potential of post-closure criticality, the consequences of a criticality excursion, and the probability frequency for post-closure criticality. The results of the NDCA are intended to provide the DOE-EM with a technical basis for measuring risk which can be used for screening arguments to eliminate post-closure criticality FEPs (features, events and processes) from consideration in the compliance assessment because of either low probability or low consequences. This report is composed of an executive summary (Volume 1), the methodology and results of the NDCA (Volume 2), and the applicable appendices (Volume 3)

Henry VIII, McLeod syndrome and Jacquetta's curse.

Science.gov (United States)

Stride, P; Lopes Floro, K

2013-01-01

The mental decline of King Henry VIII from being a jovial, charismatic and athletic young man into an increasingly paranoid, brutal tyrant in later life, ever more concerned at his lack of one or more male heirs, has attracted many medical diagnostic theories. Previous hypotheses have included diabetes, syphilis and hypothyroidism, among others. However, these inadequately explain Henry's failure to produce a male heir, despite multiple pairings. The latest postulated diagnoses for Henry are the coexistence of both Kell blood group antigenicity (possibly inherited from Jacquetta Woodville, Henry's maternal great grandmother) causing related impaired fertility, and McLeod syndrome, causing psychotic changes. As the mutated McLeod protein of the syndrome significantly reduces the expression, effectively inactivating the Kell antigen, we critically review this theory, examining in detail the pathophysiology of these conditions and assessing the genealogy of Henry VIII and its effect in subsequent generations.

Evidence for the formation of sodium hassate(VIII)

International Nuclear Information System (INIS)

Zweidorf, A. von; Angert, R.; Bruechle, W.; Buerger, S.; Eberhardt, K.; Eichler, R.; Hummrich, H.; Jaeger, E.; Kling, H.O.; Kratz, J.V.; Kuczewski, B.; Langrock, G.; Mendel, M.; Rieth, U.; Schaedel, M.; Schausten, B.; Schimpf, E.; Thoerle, P.; Trautmann, N.; Tsukada, K.; Wiehl, N.; Wirth, G.

2004-01-01

Hassium, element 108, was produced in the fusion reaction between 26 Mg and 248 Cm. The hassium recoils were oxidized in-situ to a highly volatile oxide, presumably HsO 4 , and were transported in a mixture of He and O 2 to a deposition and detection system. The latter consisted of 16 silicon PIN-photodiodes facing a layer of NaOH, which served, in the presence of a certain partial pressure of water in the transport gas, as reactive surface for the deposition of the volatile tetroxides. Six correlated α-decay chains of Hs were detected in the first 5 detectors centred around detection position 3. In analogy to OsO 4 , which forms Na 2 [OsO 4 (OH) 2 ], an osmate(VIII), with aqueous NaOH, HsO 4 presumably was deposited as Na 2 [HsO 4 (OH) 2 ], a hassate(VIII). (orig.)

The spectrum and term system of S VIII

International Nuclear Information System (INIS)

Bengtsson, P.; Jupen, C.; Engstroem, L.; Redfors, A.; Westerlind, M.

1993-01-01

The spectrum of seven times ionized sulfur, S VIII, has been observed in the wavelength range 50-1200 A. Both beam-foil and laser-produced plasma light sources have been used. 71 new lines representing the transitions 2p 5 -2p 4 3d, 2p 4 3s-3p, 3p-3d, 3d-4f, 4f-5g and 5g-6h have been identified and 100 energy levels, of which 46 are new, are now accurately established. The spectral analysis is supported by isoelectronic comparisons along the F I-sequence and by parametric least-squares fits of Slater integrals to the observed levels. The ionization potential in S VIII is determined to 2 651 899 ± 60 cm -1 and estimated ionization energies are derived for the isoelectronic elements between F I and Ar X. (orig.)

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.10--Nuclear Information sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 28 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the tenth one, the content is about Nuclear Information sub-volume

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.8--nuclear agriculture sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 10 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the eighth one, the content is about nuclear agriculture sub-volume

Second interim assessment of the Canadian concept for nuclear fuel waste disposal. Volume 1

International Nuclear Information System (INIS)

Wuschke, D.M.; Gillespie, P.A.; Main, D.E.

1985-07-01

The nuclear fuel waste disposal concept chosen for development and assessment in Canada involves the isolation of corrosion-resistant containers of waste in a vault located deep in plutonic rock. As the concept and the assessment tools are developed, periodic assessments are performed to permit evaluation of the methodology and provide feedback to those developing the concept. The ultimate goal of these assessments is to predict what impact the disposal system would have on man and the environment if the concept were implemented. The second assessment was performed in 1984 and is documented in the Second Interim assessment of the Canadian Concept for Nuclear Fuel Waste Disposal Volumes 1 to 4. This volume, entitled Summary, is a condensation of Volumes 2, 3 and 4. It briefly describes the Canadian nuclear fuel waste disposal concept, and the methods and results of the second interim pre-closure and post-closure assessments of that concept. 46 refs

Nuclear criticality experiments from 1943 to 1978: an annotated bibliography. Volume 1. Main listing

Energy Technology Data Exchange (ETDEWEB)

Koponen, B.L.; Wilcox, T.P.; Hampel, V.E.

1979-04-24

The bibliography contains 1067 citations from the literature of critical and near-critical nuclear experiments. It provides an up-to-date index to reports containing useful data for many types of criticality studies. Most of the reports can provide specifications for relatively simple critical configurations necessary for validating nuclear constants and calculational techniques. The reports of more than 1143 experimentors at 38 international facilities since 1943 are cross-referenced. The collection contains the prototypes of many different designs of nuclear reactors and studies performed to insure the safe use of fissile materials in chemical processing plants, storage facilities, and transportation containers. The bibliography has three volumes. Volume 1 contains the main listing of citations with abstracts. Volume 2 is a set of indexes organized by report number, publication date, experimental facility, and author name. Volume 3 provides a subject index, concorded on the significant keyphrases derived from titles, and an index of keyterms derived from titles, and an index of keyterms extracted from titles and abstracts. The bibliography was printed by computer as a selection from a computerized system at Lawrence Livermore Laboratory contaning information and data on criticality experiments.

Nuclear criticality experiments from 1943 to 1978. An annotated bibliography: Volume 1, main listing

International Nuclear Information System (INIS)

Koponen, B.L.; Wilcox, T.P.; Hampel, V.E.

1979-05-01

This report only describes the bibliography which contains 1067 citations from the literature of critical and near-critical nuclear experiments. The bibliography provides an up-to-date index to reports containing useful data for many types of criticality studies. Most of the reports can provide specifications for relatively simple critical configurations necessary for validating nuclear constants and calculational techniques. The reports of more than 1143 experimentors at 38 international facilities since 1943 are cross-referenced. This collection contains the prototypes of many different designs of nuclear reactors and studies performed to ensure the safe use of fissile materials in chemical processing plants, storage facilities, and transportation containers. The bibliography has three volumes. Volume 1 contains the main listing of citations with abstracts. Volume 2 is a set of indexes organized by report number, publication date, experimental facility, and author name. Volume 3 provides a subject index, concorded on the significant keyphrases derived from titles, and an index of key terms extracted from titles and abstracts. The bibliography was printed by computer as a selection from a computerized system at Lawrence Livermore Laboratory containing information and data on criticality experiments

40 CFR Appendix Viii to Part 266 - Organic Compounds for Which Residues Must Be Analyzed

Science.gov (United States)

2010-07-01

... AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Pt. 266, App. VIII Appendix VIII to Part 266... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Organic Compounds for Which Residues...

40 CFR Appendix Viii to Part 268 - LDR Effective Dates of Injected Prohibited Hazardous Wastes

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false LDR Effective Dates of Injected Prohibited Hazardous Wastes VIII Appendix VIII to Part 268 Protection of Environment ENVIRONMENTAL PROTECTION... to Part 268—LDR Effective Dates of Injected Prohibited Hazardous Wastes National Capacity LDR...

Stereological estimation of nuclear volume in benign and atypical meningiomas

DEFF Research Database (Denmark)

Madsen, C; Schrøder, H D

1993-01-01

A stereological estimation of nuclear volume in benign and atypical meningiomas was made. The aim was to investigate whether this method could discriminate between these two meningeal neoplasms. The difference was significant and it was moreover seen that there was no overlap between the two groups...

Structural characterization of the novel aminoglycoside phosphotransferase AphVIII from Streptomyces rimosus with enzymatic activity modulated by phosphorylation

Energy Technology Data Exchange (ETDEWEB)

Boyko, Konstantin M., E-mail: kmb@inbi.ras.ru [Bach Institute of Biochemistry, Federal Research Centre of Biotechnology of the Russian Academy of Sciences, Leninsky Prospekt. 33, Bld. 2, 119071, Moscow (Russian Federation); National Research Center “Kurchatov Institute”, Kurchatov Complex of NBICS-technologies, Akad. Kurchatova sqr., 1, Moscow, 123182 (Russian Federation); Gorbacheva, Marina A.; Korzhenevskiy, Dmitry A. [National Research Center “Kurchatov Institute”, Kurchatov Complex of NBICS-technologies, Akad. Kurchatova sqr., 1, Moscow, 123182 (Russian Federation); Alekseeva, Maria G.; Mavletova, Dilara A.; Zakharevich, Natalia V.; Elizarov, Sergey M.; Rudakova, Natalia N.; Danilenko, Valery N. [Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina str. 3, Moscow, 119333 (Russian Federation); Popov, Vladimir O. [Bach Institute of Biochemistry, Federal Research Centre of Biotechnology of the Russian Academy of Sciences, Leninsky Prospekt. 33, Bld. 2, 119071, Moscow (Russian Federation); National Research Center “Kurchatov Institute”, Kurchatov Complex of NBICS-technologies, Akad. Kurchatova sqr., 1, Moscow, 123182 (Russian Federation)

2016-09-02

Aminoglycoside phosphotransferases represent a broad class of enzymes that promote bacterial resistance to aminoglycoside antibiotics via the phosphorylation of hydroxyl groups in the latter. Here we report the spatial structure of the 3′-aminoglycoside phosphotransferase of novel VIII class (AphVIII) solved by X-ray diffraction method with a resolution of 2.15 Å. Deep analysis of APHVIII structure and its comparison with known structures of aminoglycoside phosphotransferases of various types reveals that AphVIII has a typical two-domain fold and, however, possesses some unique characteristics that distinguish the enzyme from its known homologues. The most important difference is the presence of the activation loop with unique Ser146 residue. We demonstrate that in the apo-state of the enzyme the activation loop does not interact with other parts of the enzyme and seems to adopt catalytically competent state only after substrate binding. - Highlights: • 3D structure of the novel aminoglycoside phosphotransferase AphVIII was obtained. • AphVIII activation loop is clearly identified in the electron density. • AphVIII has some unique structural features in its substrate C-ring binding pocket.

Hemodialysis in a patient with severe hemophilia A and factor VIII inhibitor.

Science.gov (United States)

Gopalakrishnan, Natarajan; Usha, Thiruvengadam; Thopalan, Balasubramaniyan; Dhanapriya, Jeyachandran; Dineshkumar, Thanigachalam; Thirumalvalavan, Kaliaperumal; Sakthirajan, Ramanathan

2016-10-01

Hemophilia A is a hereditary X-linked recessive disease caused by mutations in the gene encoding factor VIII (FVIII), occurring in 1 out of 10,000 persons. Life expectancy and quality of life have dramatically improved recently in patients with hemophilia. Chronic kidney disease and need for renal replacement therapy in these patients are rare. The development of inhibitors to FVIII is the most serious complication of hemophilia and makes treatment of bleeds very challenging. We describe here a 28-year-old male patient with severe hemophilia A with presence of factor VIII inhibitor, who had end stage renal disease. Central venous access device was inserted along with infusion of factor eight inhibitor bypass activity before and after the procedure. He is currently on thrice weekly hemodialysis and doing well for 6 months without bleeding episodes. To our knowledge, hemophilia A with factor VIII inhibitor managed with hemodialysis has not been reported so far. © 2016 International Society for Hemodialysis.

Spectrophotometric determination of hydrogen peroxide with osmium(VIII) and m-carboxyphenylfluorone.

Science.gov (United States)

Hoshino, Mitsuru; Kamino, Shinichiro; Doi, Mitsunobu; Takada, Shingo; Mitani, Shota; Yanagihara, Rika; Asano, Mamiko; Yamaguchi, Takako; Fujita, Yoshikazu

2014-01-03

Spectrophotometric determination of hydrogen peroxide was accomplished with osmium(VIII) and m-carboxyphenylfluorone (MCPF) in the presence of cetyltrimethylammonium chloride (CTAC). In the determination of hydrogen peroxide based on the fading of the color of osmium(VIII)-MCPF complex, Beer's law was obeyed in the range 20-406 ng mL(-1), with an effective molar absorption coefficient (at 580 nm) of 5.21×10(4) L mol(-1) cm(-1) and a relative standard deviation of 0.33% (n=6). Further, we performed the characterization of MCPF and obtained the crystal structure. Copyright © 2013 Elsevier B.V. All rights reserved.

Stereological estimation of nuclear volume in benign and malignant melanocytic lesions of the skin. Inter- and intraobserver variability of malignancy grading

DEFF Research Database (Denmark)

Sørensen, Flemming Brandt; Ottosen, P D

1991-01-01

The volume-weighted, mean nuclear volume (nuclear vv) may be estimated without any assumptions regarding nuclear shape using modern stereological techniques. As a part of an investigation concerning the prospects of nuclear vv for classification and malignancy grading of cutaneous melanocytic tum...

Organizational analysis and safety for utilities with nuclear power plants: perspectives for organizational assessment. Volume 2. [PWR; BWR

Energy Technology Data Exchange (ETDEWEB)

Osborn, R.N.; Olson, J.; Sommers, P.E.; McLaughlin, S.D.; Jackson, M.S.; Nadel, M.V.; Scott, W.G.; Connor, P.E.; Kerwin, N.; Kennedy, J.K. Jr.

1983-08-01

This two-volume report presents the results of initial research on the feasibility of applying organizational factors in nuclear power plant (NPP) safety assessment. Volume 1 of this report contains an overview of the literature, a discussion of available safety indicators, and a series of recommendations for more systematically incorporating organizational analysis into investigations of nuclear power plant safety. The six chapters of this volume discuss the major elements in our general approach to safety in the nuclear industry. The chapters include information on organizational design and safety; organizational governance; utility environment and safety related outcomes; assessments by selected federal agencies; review of data sources in the nuclear power industry; and existing safety indicators.

Volume reduction technology development for solid wastes from the nuclear fuel cycle

International Nuclear Information System (INIS)

Oh, Won Zin; Lee, Kune Woo; Song, Kee Chan; Choi, Wang Kyu; Kim, Young Min

1998-07-01

A great deal of solid wastes, which have various physical, chemical, and radiological characteristics, are generated from the nuclear fuel cycle facility as well as radioactive gaseous and liquid wastes. The treatment of the large quantity of solid wastes from the nuclear fuel cycle have great technical, economical and social effects on the domestic policy decision on the nuclear fuel cycle, such as operation and maintenance of the facility, waste disposal, etc. Cement immobilization, super compaction, and electrochemical dissolution were selected as the volume reduction technologies for solid wastes, which will generated from the domestic nuclear fuel cycle facility in the future. And the assessment of annual arisings and the preliminary conceptual design of volume reduction processes were followed. Electrochemical decontamination of α-radionuclides from the spent fuel hulls were experimentally investigated, and showed the successful results. However, β/γ radioactivity did not reduce to the level below which hulls can be classified as the low-level radioactive waste and sent to the disposal site for the shallow land burial. The effects of the various process variables in the electrochemical decontamination were experimentally analysed on the process. (author). 32 refs., 32 tabs., 52 figs

Nuclear regulatory legislation, 104th Congress. Volume 2, No. 4

International Nuclear Information System (INIS)

1997-12-01

This document is the second of two volumes compiling statutes and material pertaining to nuclear regulatory legislation through the 104th Congress, 2nd Session. It is intended for use as a U.S. Nuclear Regulatory Commission (NRC) internal resource document. Legislative information reproduced in this document includes portions of the Paperwork Reduction Act, various acts pertaining to low-level radioactive waste, the Clean Air Act, the Federal Water Pollution Control Act, the National Environmental Policy Act, the Hazardous Materials Transportation Act, the West Valley Demonstration Project Act, Nuclear Non-Proliferation and Export Licensing Statutes, and selected treaties, agreements, and executive orders. Other information provided pertains to Commissioner tenure, NRC appropriations, the Chief Financial Officers Act, information technology management reform, and Federal civil penalties

Nuclear regulatory legislation, 104th Congress. Volume 2, No. 4

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-12-01

This document is the second of two volumes compiling statutes and material pertaining to nuclear regulatory legislation through the 104th Congress, 2nd Session. It is intended for use as a U.S. Nuclear Regulatory Commission (NRC) internal resource document. Legislative information reproduced in this document includes portions of the Paperwork Reduction Act, various acts pertaining to low-level radioactive waste, the Clean Air Act, the Federal Water Pollution Control Act, the National Environmental Policy Act, the Hazardous Materials Transportation Act, the West Valley Demonstration Project Act, Nuclear Non-Proliferation and Export Licensing Statutes, and selected treaties, agreements, and executive orders. Other information provided pertains to Commissioner tenure, NRC appropriations, the Chief Financial Officers Act, information technology management reform, and Federal civil penalties.

Nuclear Dynamics Consequence Analysis (NDCA) for the Disposal of Spent Nuclear Fuel in an Underground Geologic Repository--Volume 1: Executive Summary

International Nuclear Information System (INIS)

Taylor, L.L.; Wilson, J.R.; Sanchez, L.Z.; Aguilar, R.; Trellue, H.R.; Cochrane, K.; Rath, J.S.

1998-01-01

The US Department of Energy Office of Environmental Management's (DOE/EM's) National Spent Nuclear Fuel Program (NSNFP), through a collaboration between Sandia National Laboratories (SNL) and Idaho National Engineering and Environmental Laboratory (INEEL), is conducting a systematic Nuclear Dynamics Consequence Analysis (NDCA) of the disposal of SNFs in an underground geologic repository sited in unsaturated tuff. This analysis is intended to provide interim guidance to the DOE for the management of the SNF while they prepare for final compliance evaluation. This report presents results from a Nuclear Dynamics Consequence Analysis (NDCA) that examined the potential consequences and risks of criticality during the long-term disposal of spent nuclear fuel owned by DOE-EM. This analysis investigated the potential of post-closure criticality, the consequences of a criticality excursion, and the probability frequency for post-closure criticality. The results of the NDCA are intended to provide the DOE-EM with a technical basis for measuring risk which can be used for screening arguments to eliminate post-closure criticality FEPs (features, events and processes) from consideration in the compliance assessment because of either low probability or low consequences. This report is composed of an executive summary (Volume 1), the methodology and results of the NDCA (Volume 2), and the applicable appendices (Volume 3)

International Source Book: Nuclear Fuel Cycle Research and Development Vol 1 Volume 1

Energy Technology Data Exchange (ETDEWEB)

Harmon, K. M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Lakey, L. T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

1983-07-01

This document starts with an overview that summarizes nuclear power policies and waste management activities for nations with significant commercial nuclear fuel cycle activities either under way or planned. A more detailed program summary is then included for each country or international agency conducting nuclear fuel cycle and waste management research and development. This first volume includes the overview and the program summaries of those countries listed alphabetically from Argentina to Italy.

Nuclear Fuel Recovery and Recycling Center. License application, PSAR, volume 3

International Nuclear Information System (INIS)

1976-01-01

Volume 3 comprises Chapter 5 which provides descriptive information on Nuclear Fuel Recovery and Recycling Center buildings and other facilities, including their locations. The design features discussed include those used to withstand environmental and accidental forces and to insure radiological protection

Stereological estimation of nuclear volume and other quantitative histopathological parameters in the prognostic evaluation of supraglottic laryngeal squamous cell carcinoma

DEFF Research Database (Denmark)

Sørensen, Flemming Brandt; Bennedbaek, O; Pilgaard, J

1989-01-01

The aim of this study was to investigate various approaches to the grading of malignancy in pre-treatment biopsies from patients with supraglottic laryngeal squamous cell carcinoma. The prospects of objective malignancy grading based on stereological estimation of the volume-weighted mean nuclear...... volume, nuclear Vv, and nuclear volume fraction, Vv(nuc/tis), along with morphometrical 2-dimensional estimation of nuclear density index, NI, and mitotic activity index, MI, were investigated and compared with the current morphological, multifactorial grading system. The reproducibility among two...... observers of the latter was poor in the material which consisted of 35 biopsy specimens. Unbiased estimates of nuclear Vv were on the average 385 microns3 (CV = 0.44), with more than 90% of the associated variance attributable to differences in nuclear Vv among individual lesions. Nuclear Vv was positively...

Factor VIII-associated antigen in human lymphatic endothelium.

Science.gov (United States)

Nagle, R B; Witte, M H; Martinez, A P; Witte, C L; Hendrix, M J; Way, D; Reed, K

1987-03-01

Lymphatic vascular endothelium both on tissue section and in culture exhibits positivity for Factor VIII-associated antigen although staining is generally less intense and more spotty than in comparable blood vascular endothelium. Lymphatic endothelium also exhibits Weibel-Palade bodies. Neither marker, therefore, reliably distinguishes blood vascular endothelium from lymphatic endothelium.

Organizational analysis and safety for utilities with nuclear power plants: an organizational overview. Volume 1. [PWR; BWR

Energy Technology Data Exchange (ETDEWEB)

Osborn, R.N.; Olson, J.; Sommers, P.E.; McLaughlin, S.D.; Jackson, M.S.; Scott, W.G.; Connor, P.E.

1983-08-01

This two-volume report presents the results of initial research on the feasibility of applying organizational factors in nuclear power plant (NPP) safety assessment. A model is introduced for the purposes of organizing the literature review and showing key relationships among identified organizational factors and nuclear power plant safety. Volume I of this report contains an overview of the literature, a discussion of available safety indicators, and a series of recommendations for more systematically incorporating organizational analysis into investigations of nuclear power plant safety.

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.3--nuclear power sub-volume (Pt.2)

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 86 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the third one, the content is about nuclear power sub-volume (Pt.2)

Time Transfer Experiment by TCE on the ETS-VIII Satellite

National Research Council Canada - National Science Library

Nakagawa, Fumimaru; Takahashi, Yasuhiro; Amagai, Jun; Tabuchi, Ryo; Hama, Shin'ichi; Hosokawa, Mizuhiko

2007-01-01

.... At NICT, we developed Time Comparison Equipment (TCE) both onboard ETS-VIII and in the Earth station for precise time transfer between the atomic clocks on the satellite and a ground reference clock...

Historical sketches of Sandia National Laboratories nuclear field testing. Volume 1: Full discussion except for sensitive references

International Nuclear Information System (INIS)

Banister, J.R.

1994-10-01

This report contains historical sketches that cover the major activities of Sandia nuclear field testing, from early atmospheric shots until 1990. It includes a chronological overview followed by more complete discussions of atmospheric, high-altitude, underwater, cratering, and underground nuclear testing. Other activities related to nuclear testing and high-explosive tests are also described. A large number of references are cited for readers who wish to learn more about technical details. Appendices, written by several authors, provide more insight for a variety of special aspects of nuclear testing and related work. Two versions of this history were published: volume 1 has an unlimited distribution, and volume 2 has a limited distribution

Barnwell Nuclear Fuels Plant applicability study. Volume III. Appendices

International Nuclear Information System (INIS)

1978-03-01

Volume III suppliees supporting information to assist Congress in making a decision on the optimum utilization of the Barnwell Nuclear Fuels Plant. Included are applicable fuel cycle policies; properties of reference fuels; description and evaluation of alternative operational (flue cycle) modes; description and evaluation of safeguards systems and techniques; description and evaluation of spiking technology; waste and waste solidification evaluation; and Department of Energy programs relating to nonproliferation

Nuclear Dynamics Consequence Analysis (NDCA) for the Disposal of Spent Nuclear Fuel in an Underground Geologic Repository--Volume 2: Methodology and Results

International Nuclear Information System (INIS)

Taylor, L.L.; Wilson, J.R.; Sanchez, L.C.; Aguilar, R.; Trellue, H.R.; Cochrane, K.; Rath, J.S.

1998-01-01

The US Department of Energy Office of Environmental Management's (DOE/EM's) National Spent Nuclear Fuel Program (NSNFP), through a collaboration between Sandia National Laboratories (SNL) and Idaho National Engineering and Environmental Laboratory (INEEL), is conducting a systematic Nuclear Dynamics Consequence Analysis (NDCA) of the disposal of SNFs in an underground geologic repository sited in unsaturated tuff. This analysis is intended to provide interim guidance to the DOE for the management of the SNF while they prepare for final compliance evaluation. This report presents results from a Nuclear Dynamics Consequence Analysis (NDCA) that examined the potential consequences and risks of criticality during the long-term disposal of spent nuclear fuel owned by DOE-EM. This analysis investigated the potential of post-closure criticality, the consequences of a criticality excursion, and the probability frequency for post-closure criticality. The results of the NDCA are intended to provide the DOE-EM with a technical basis for measuring risk which can be used for screening arguments to eliminate post-closure criticality FEPs (features, events and processes) from consideration in the compliance assessment because of either low probability or low consequences. This report is composed of an executive summary (Volume 1), the methodology and results of the NDCA (Volume 2), and the applicable appendices (Volume 3)

Nuclear Dynamics Consequence Analysis (NDCA) for the Disposal of Spent Nuclear Fuel in an Underground Geologic Repository--Volume 2: Methodology and Results

Energy Technology Data Exchange (ETDEWEB)

Taylor, L.L.; Wilson, J.R.; Sanchez, L.C.; Aguilar, R.; Trellue, H.R.; Cochrane, K.; Rath, J.S.

1998-10-01

The US Department of Energy Office of Environmental Management's (DOE/EM's) National Spent Nuclear Fuel Program (NSNFP), through a collaboration between Sandia National Laboratories (SNL) and Idaho National Engineering and Environmental Laboratory (INEEL), is conducting a systematic Nuclear Dynamics Consequence Analysis (NDCA) of the disposal of SNFs in an underground geologic repository sited in unsaturated tuff. This analysis is intended to provide interim guidance to the DOE for the management of the SNF while they prepare for final compliance evaluation. This report presents results from a Nuclear Dynamics Consequence Analysis (NDCA) that examined the potential consequences and risks of criticality during the long-term disposal of spent nuclear fuel owned by DOE-EM. This analysis investigated the potential of post-closure criticality, the consequences of a criticality excursion, and the probability frequency for post-closure criticality. The results of the NDCA are intended to provide the DOE-EM with a technical basis for measuring risk which can be used for screening arguments to eliminate post-closure criticality FEPs (features, events and processes) from consideration in the compliance assessment because of either low probability or low consequences. This report is composed of an executive summary (Volume 1), the methodology and results of the NDCA (Volume 2), and the applicable appendices (Volume 3).

Optimal design of condenser volume in nuclear power plant

International Nuclear Information System (INIS)

Zheng Jing; Yan Changqi; Wang Jianjun

2011-01-01

The condenser is an important component in the nuclear power plant,whose dimension will influence the economy and the arrangement of the nuclear power plant.In this paper, the calculation model was established according to the design experience. The corresponding codes were also developed. The sensitivity of design parameters which influence the condenser Janume was analyzed. The present optimal design of the condenser, aiming at the volume minimization, was carried out with the self-developed complex-genetic algorithm. The results show that the reference condenser design is far from the best scheme. In addition, the results also verify the feasibility of the complex-genetic algorithm. Furthermore, the results of this paper can provide reference for the design of the condenser. (authors)

Nuclear materials 1993 annual report. Volume 8, No. 2

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-05-01

This annual report of the US Nuclear Regulatory Commission`s Office for Analysis and Evaluation of Operational Data (AEOD) describes activities conducted during 1993. The report is published in two parts. NUREG-1272, Vol. 8, No. 1, covers power reactors and presents an overview of the operating experience of the nuclear power industry from the NRC perspective, including comments about the trends of some key performance measures. The report also includes the principal findings and issues identified in AEOD studies over the past year and summarizes information from such sources as licensee event reports, diagnostic evaluations, and reports to the NRC`s Operations Center. NUREG-1272, Vol. 8, No. 2, covers nuclear materials and presents a review of the events and concerns during 1993 associated with the use of licensed material in nonreactor applications, such as personnel overexposures and medical misadministrations. Note that the subtitle of No. 2 has been changed from ``Nonreactors`` to ``Nuclear Materials.`` Both reports also contain a discussion of the Incident Investigation Team program and summarize both the Incident Investigation Team and Augmented Inspection Team reports. Each volume contains a list of the AEOD reports issued from 1980 through 1993.

Nuclear materials 1993 annual report. Volume 8, No. 2

International Nuclear Information System (INIS)

1995-05-01

This annual report of the US Nuclear Regulatory Commission's Office for Analysis and Evaluation of Operational Data (AEOD) describes activities conducted during 1993. The report is published in two parts. NUREG-1272, Vol. 8, No. 1, covers power reactors and presents an overview of the operating experience of the nuclear power industry from the NRC perspective, including comments about the trends of some key performance measures. The report also includes the principal findings and issues identified in AEOD studies over the past year and summarizes information from such sources as licensee event reports, diagnostic evaluations, and reports to the NRC's Operations Center. NUREG-1272, Vol. 8, No. 2, covers nuclear materials and presents a review of the events and concerns during 1993 associated with the use of licensed material in nonreactor applications, such as personnel overexposures and medical misadministrations. Note that the subtitle of No. 2 has been changed from ''Nonreactors'' to ''Nuclear Materials.'' Both reports also contain a discussion of the Incident Investigation Team program and summarize both the Incident Investigation Team and Augmented Inspection Team reports. Each volume contains a list of the AEOD reports issued from 1980 through 1993

Quality assurance program manual for nuclear power plants. Volume I. Policies

International Nuclear Information System (INIS)

1976-01-01

The Consumers Power Company Quality Assurance Program Manual for Nuclear Power Plants consists of policies and procedures which comply with current NRC regulatory requirements and industry codes and standards in effect during the design, procurement, construction, testing, operation, refueling, maintenance, repair and modification activities associated with nuclear power plants. Specific NRC and industry documents that contain the requirements, including the issue dates in effect, are identified in each nuclear power plant's Safety Analysis Report. The requirements established by these documents form the basis for the Consumer Power Quality Assurance Program, which is implemented to control those structures, systems, components and operational safety actions listed in each nuclear power plant's Quality List (Q-List). As additional and revised requirements are issued by the NRC and professional organizations involved in nuclear activities, they will be reviewed for their impact on this manual, and changes will be made where considered necessary. CP Co 1--Consumers Power Company QA Program Topical Report is Volume I of this manual and contains Quality Assurance Program Policies applicable during all phases of nuclear power plant design, construction and operation

Improving nuclear regulation. NEA regulatory guidance booklets volumes 1-14

International Nuclear Information System (INIS)

2011-01-01

A common theme throughout the series of NEA regulatory guidance reports, or 'green booklets', is the premise that the fundamental objective of all nuclear safety regulatory bodies is to ensure that nuclear facilities are continuously maintained and operated in an acceptably safe manner. In meeting this objective the regulator must bear in mind that it is the operator that has responsibility for safely operating the nuclear facility; the role of the regulator is to assess and to provide assurance regarding the operator's activities in terms of assuming that responsibility. The full series of these reports was brought together in one edition for the first time in 2009 and was widely found to be a useful resource. This second edition comprises 14 volumes, including the latest on The Nuclear Regulator's Role in Assessing Licensee Oversight of Vendor and Other Contracted Services. The reports address various challenges that could apply throughout the lifetime of a nuclear facility, including design, siting, manufacturing, construction, commissioning, operation, maintenance and decommissioning. The compilation is intended to serve as a knowledge management tool both for current regulators and the new nuclear professionals and organisations entering the regulatory field. Contents: Executive Summary; Regulatory Challenges: 1. The Role of the Nuclear Regulator in Promoting and Evaluating Safety Culture; 2. Regulatory Response Strategies for Safety Culture Problems; 3. Nuclear Regulatory Challenges Related to Human Performance; 4. Regulatory Challenges in Using Nuclear Operating Experience; 5. Nuclear Regulatory Review of Licensee Self-assessment (LSA); 6. Nuclear Regulatory Challenges Arising from Competition in Electricity Markets; 7. The Nuclear Regulatory Challenge of Judging Safety Back-fits; 8. The Regulatory Challenges of Decommissioning Nuclear Reactors; 9. The Nuclear Regulator's Role in Assessing Licensee Oversight of Vendor and Other Contracted Services

Mechanistic aspects of Os(VIII) catalysed oxidation of loop diuretic ...

Indian Academy of Sciences (India)

furosemide by Ag(III) periodate complex in aqueous alkaline medium. SHWETA J .... Os(VIII) catalysed DPA oxidation, the order in [OH. −. ] ... Victoria-3170, Australia) connected to a rapid ..... follows. The furosemide, periodate and hydroxide ion.

Stereological estimates of nuclear volume in the prognostic evaluation of primary flat carcinoma in situ of the urinary bladder

DEFF Research Database (Denmark)

Sørensen, Flemming Brandt; Jacobsen, F

1991-01-01

Primary, flat carcinoma in situ of the urinary bladder is rare and its behaviour is unpredictable. The aim of this retrospective study was to obtain base-line data and investigate the prognostic value of unbiased, stereological estimates of the volume-weighted mean nuclear volume, nuclear vv, in ...

Stereological quantification of tumor volume, mean nuclear volume and total number of melanoma cells correlated with morbidity and mortality

DEFF Research Database (Denmark)

Bønnelykke-Behrndtz, Marie Louise; Sørensen, Flemming Brandt; Damsgaard, Tine Engberg

2008-01-01

potential indicators of prognosis. Sixty patients who underwent surgery at the Department of Plastic Surgery, Aarhus University Hospital, from 1991 to 1994 were included in the study. Total tumor volume was estimated by the Cavalieri technique, total number of tumor cells by the optical dissector principle...... showed a significant impact on both disease-free survival (p=0.001) and mortality (p=0.009). In conclusion, tumor volume and total number of cancer cells were highly reproducible but did not add additional, independent prognostic information regarding the study population.......Stereological quantification of tumor volume, total number of tumor cells and mean nuclear volume provides unbiased data, regardless of the three-dimensional shape of the melanocytic lesion. The aim of the present study was to investigate whether these variables are reproducible and may represent...

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.7--nuclear fusion and plasma physics sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 22 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the seventh one, the content is about nuclear fusion and plasma physics sub-volume

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.9--nuclear technology applied in industry sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 35 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the ninth one, the content is about nuclear technology applied in industry sub-volume

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.4--Nuclear chemistry and radiation chemistry sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 24 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the fourth one, the content is about Nuclear chemistry and radiation chemistry sub-volume

PERSEPSI SISWA KELAS VIII TENTANG KESEHATAN REPRODUKSI REMAJA DAN PENYAKIT MENULAR SEKSUAL

Directory of Open Access Journals (Sweden)

Omega Rianda Rustian

2015-06-01

This study is based on interviews conducted in one of the BK school teacher. This study aimed to determine the perception class VIII student perceptions on adolescent reproductive health and sexually transmitted diseases in SMP Islam Sultan Agung 1 Semarang. The method used in this research is descriptive quantitative survey methods. Population in this research is class VIII SMP Islam Sultan Agung 1 Semarang totaling 151 students with a sampling technique used is accidental to obtain a sample of 60. Data collection tools in the form of a psychological scale with data analysis techniques using descriptive analysis percentage. The average result of students' perceptions on adolescent reproductive health in the high category (74% and perceptions of students about sexually transmitted diseases in the very high category (76%. That class VIII SMP Islam Sultan Agung 1 Semarang already have an idea of the meaning of adolescent reproductive health is a state of good health both physically healthy, functioning, as well as reproductive performance in adolescent and the  meaning of sexually transmitted diseases are caused by viruses, parasites, or function as a result of sexual intercourse.

State of the art review of radioactive waste volume reduction techniques for commercial nuclear power plants

International Nuclear Information System (INIS)

1980-04-01

A review is made of the state of the art of volume reduction techniques for low level liquid and solid radioactive wastes produced as a result of: (1) operation of commercial nuclear power plants, (2) storage of spent fuel in away-from-reactor facilities, and (3) decontamination/decommissioning of commercial nuclear power plants. The types of wastes and their chemical, physical, and radiological characteristics are identified. Methods used by industry for processing radioactive wastes are reviewed and compared to the new techniques for processing and reducing the volume of radioactive wastes. A detailed system description and report on operating experiences follow for each of the new volume reduction techniques. In addition, descriptions of volume reduction methods presently under development are provided. The Appendix records data collected during site surveys of vendor facilities and operating power plants. A Bibliography is provided for each of the various volume reduction techniques discussed in the report

Factor VIII levels and the risk of pre-eclampsia, HELLP syndrome, pregnancy related hypertension and severe intrauterine growth retardation.

Science.gov (United States)

Witsenburg, C P J; Rosendaal, F R; Middeldorp, J M; Van der Meer, F J M; Scherjon, S A

2005-01-01

Recently, acquired as well as genetic prothrombotic factors are associated with thrombotic events. These factors have also been related to conditions of uteroplacental insufficiency such as pre-eclampsia, HELLP syndrome and severe intrauterine growth restriction (IUGR). The aim of this study was to determine whether elevated factor VIII levels are associated with uteroplacental insufficiency, in particular pre-eclampsia, HELLP syndrome or pregnancy-induced hypertension and intrauterine growth retardation. Plasma samples of 75 women with a history of pregnancy complicated by pre-eclampsia, HELLP syndrome, pregnancy induced hypertension or intrauterine growth restriction were tested for factor VIII:C (FVIII:C) levels at a minimum of 10 weeks post-partum. Laboratory results were compared to factor VIII:C levels found in a healthy control group of 272 women. Mean factor VIII:C levels were similar at 123 IU/dl in both the patient group and the controls. In a logistic regression model, after adjusting for age and blood group, no effect of factor VIII:C levels on the risk of pregnancy complications was observed, with the exception of IUGR with (OR 2.9, CI 1.0-8.7) or without hypertension (OR 2.0, CI 0.7-6.4). If the elevated level of factor VIII would be the sole factor responsible for the increased risk observed, one would expect to find an effect of blood group on risk as well (blood group being an important determinant of FVIII:C). While no such effect could be shown a causal relationship between elevated levels of factor VIII and conditions of uteroplacental insufficiency such as pre-eclampsia, HELLP syndrome, pregnancy-induced hypertension and IUGR is not very likely.

Class VIII Medical Materiel Controls in the U.S. European Command

National Research Council Canada - National Science Library

1991-01-01

.... Class VIII medical materiel inventories are maintained as part of the U.S. war reserve stocks to ensure military readiness and to provide needed health care during wartime or contingencies. The U.S...

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.10--nuclear technology economy and management modernization sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 18 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the tenth one, the content is about nuclear technology economy and management modernization sub-volume

Construction of a mouse model of factor VIII deficiency by gene targeting

Energy Technology Data Exchange (ETDEWEB)

Bi, L.; Lawler, A.; Gearhart, J. [Univ. of Pennsylvania School of Medicine, Philadelphia, PA (United States)] [and others

1994-09-01

To develop a small animal model of hemophilia A for gene therapy experiments, we set out to construct a mouse model for factor VIII deficiency by gene targeting. First, we screened a mouse liver cDNA library using a human FVIII cDNA probe. We cloned a 2.6 Kb partial mouse factor VIII cDNA which extends from 800 base pairs of the 3{prime} end of exon 14 to the 5{prime} end of exon 26. A mouse genomic library made from strain 129 was then screened to obtain genomic fragments covering the exons desired for homologous recombination. Two genomic clones were obtained, and one covering exon 15 through 22 was used for gene targeting. To make gene targeting constructs, a 5.8 Kb genomic DNA fragment covering exons 15 to 19 of the mouse FVIII gene was subcloned, and the neo expression cassette was inserted into exons 16 and 17 separately by different strategies. These two constructs were named MFVIIIC-16 and MFVIIIC-17. The constructs were linearized and transfected into strain 129 mouse ES cells by electroporation. Factor VIII gene-knockout ES cell lines were selected by G-418 and screened by genomic Southern blots. Eight exon 16 targeted cell lines and five exon 17 targeted cell lines were obtained. Three cell lines from each construct were injected into blastocysts and surgically transferred into foster mothers. Multiple chimeric mice with 70-90% hair color derived from the ES-cell genotype were seen with both constructs. Germ line transmission of the ES-cell genotype has been obtained for the MFVIIIC-16 construct, and multiple hemophilia A carrier females have been identified. Factor VIII-deficient males will be conceived soon.

RELATIONSHIP OF INTEREST, LEARNING MOTIVATION AND ATTITUDE WITH RESULTS LEARNING CLASS VIII SMP STATE 13 MAKASSAR

Directory of Open Access Journals (Sweden)

Putri Athirah Azis

2016-12-01

Full Text Available The study aims at examining (1 the correlation of learning interest towards learning result of grade students, (2 the correlation of learning motivation towards learning result of grade students, (3 the correlation of students attitude towards learning result, (4 the correlationof interest, learning motivation, and attitude collaboratively towards learning result. The study is an ex post facto. The population of the study was grade VIII at SMPN 13 Makassar. Samples were 105 students taken by employing random sampling technique. Data were collected through questionnaire and documentation. Data were analyzed using regression test. The result of study reveal that (1 there is significant correlation (p<0,01 of interest towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,718 and its effectiveness contribution (R2 is 51,5%, (2 there is significant correlation (p<0,01 of motivation towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,775 and its effectiveness contribution (R2 is 60,1%, (3 there is significant correlation (p<0,01 of attitude towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,737 and its effectiveness contribution (R2 is 54,4%, (4 there is significant correlation (p<0,01 of interest, motivation and attitude collaboratively towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,861 and its effectiveness contribution (R2 is 74,1%,

Compact invariant sets of the Bianchi VIII and Bianchi IX Hamiltonian systems

International Nuclear Information System (INIS)

Starkov, Konstantin E.

2011-01-01

In this Letter we prove that all compact invariant sets of the Bianchi VIII Hamiltonian system are contained in the set described by several simple linear equalities and inequalities. Moreover, we describe invariant domains in which the phase flow of this system has no recurrence property and show that there are no periodic orbits and neither homoclinic, nor heteroclinic orbits contained in the zero level set of its Hamiltonian. Similar results are obtained for the Bianchi IX Hamiltonian system. -- Highlights: → Zero level set of Hamiltonian of Bianchi VIII/IX systems contains no periodic orbits. → Similar conditions for homoclinic/heteroclinic orbits are given. → General nonexistence conditions of compact invariant sets are got.

Compact invariant sets of the Bianchi VIII and Bianchi IX Hamiltonian systems

Energy Technology Data Exchange (ETDEWEB)

Starkov, Konstantin E., E-mail: konst@citedi.mx [CITEDI-IPN, Av. del Parque 1310, Mesa de Otay, Tijuana, BC (Mexico)

2011-08-22

In this Letter we prove that all compact invariant sets of the Bianchi VIII Hamiltonian system are contained in the set described by several simple linear equalities and inequalities. Moreover, we describe invariant domains in which the phase flow of this system has no recurrence property and show that there are no periodic orbits and neither homoclinic, nor heteroclinic orbits contained in the zero level set of its Hamiltonian. Similar results are obtained for the Bianchi IX Hamiltonian system. -- Highlights: → Zero level set of Hamiltonian of Bianchi VIII/IX systems contains no periodic orbits. → Similar conditions for homoclinic/heteroclinic orbits are given. → General nonexistence conditions of compact invariant sets are got.

Stereological estimates of nuclear volume in normal germ cells and carcinoma in situ of the human testis

DEFF Research Database (Denmark)

Sørensen, Flemming Brandt; Müller, J

1990-01-01

Carcinoma in situ of the testis may appear many years prior to the development of an invasive tumour. Using point-sampled intercepts, base-line data concerning unbiased stereological estimates of the volume-weighted mean nuclear volume (nuclear vV) were obtained in 50 retrospective serial...... testicular biopsies from 10 patients with carcinoma in situ. All but two patients eventually developed an invasive growth. Testicular biopsies from 10 normal adult individuals and five prepubertal boys were included as controls. Nuclear vV in testicular carcinoma in situ was significantly larger than...... that of morphologically normal spermatogonia (2P = 1.0 x 10(-19)), with only minor overlap. Normal spermatogonia from controls had, on average, smaller nuclear vV than morphologically normal spermatogonia in biopsies with ipsi- or contra-lateral carcinoma in situ (2P = 5.2 x 10(-3)). No difference in nuclear vV was found...

Successful Pregnancy in a Patient with Combined Deficiency of Factor V and Factor VIII.

Science.gov (United States)

El Adib, Ahmed Ghassan; Majdi, Farah; Dilai, Mohamed Othmane; Asmouki, Hamid; Bassir, Ahlam; Harou, Karam; Soumani, Abderraouf; Younous, Said; Mahmal, Lahoucine

2014-01-01

Inherited combined factor V and factor VIII deficiency (F5F8D) is autosomal recessive transmission disorder. Epistaxis, postsurgical bleeding, and menorrhagia are the most common symptoms. The risk of miscarriage and placental abruption is consequent. We report a case of successful pregnancy in a patient with F5F8D. 20-year-old woman, born of consanguineous parents, third gestate, first parity, two miscarriages, admitted for child birth of a spontaneous pregnancy estimated at 38 weeks and was diagnosed with F5F8D. At admission, patient was hemodynamically stable, with good obstetric conditions. The biologic results showed low levels of PT (52%), factor V (7%), and factor VIII (5%), and the activated partial thromboplastin time was prolonged (68,6%). Parturient was admitted in intensive care unit, maternal and fetal monitoring was performed. Fresh frozen plasma (FFP) and factor VIII concentrates were perfused at the induction of labor. Analgesia used fentanyl titration. The delivery gave birth to a newborn male, with Apgar 10/10 and 3000 g. The puerperium was simple without any important bleeding. Laboratory tests for the newborn were acceptable. Little literature is available on this subject and there are no guidelines available concerning pregnancy; we chose to prescribe a combination of factor VIII concentrate and FFP in pre-, per- and postpartum. The same protocol was successfully used in a patient before dental extraction and prostatectomy. Vaginal delivery is possible, as our case. Management by multidisciplinary team is recommended.

A close insight to factor VIII inhibitor in the congenital hemophilia A.

Science.gov (United States)

Tabriznia-Tabrizi, Shamsoreza; Gholampour, Marzie; Mansouritorghabeh, Hassan

2016-09-01

Hemophilia A (HA) has an X-linked pattern of inheritance and is the most common of the hemorrhagic disorders. HA is caused by a decreased or deficiency of the functional clotting factor VIII (FVIII) and effects 1 in 5000-10,000 male births. The common treatment for hemophilia is replacement therapy by plasma-derived or recombinant FVIII. Approximately 20-30% of people with a severe type of HA develop an inhibitor and this phenomenon is the main challenge in the management of these patients. Genetic factors and environmental determinants contribute to inhibitor development. Here, the roles of various genetic and environmental factors such as the type of FVIII concentrate used, the number of exposure days, and peak treatment time will be discussed in detail. It seems this information is helpful for hematologists. A literature review was done in January 2016 on PubMed and Scopus using the following keywords:' h(a)emophilia A & factor VIII inhibitor', 'h(a)emophilia A & factor VIII alloantibody', 'h(a)emophilia A & inhibitor'. There was no time limitation; however, there was an English language limitation placed on the articles selected. Expert commentary: Influential genetic and environmental factors in developing inhibitors have been discussed. Most of the risk factors are related to previously untreated patients with hemophili.

Efficacy and safety of rVIII-SingleChain: results of a phase 1/3 multicenter clinical trial in severe hemophilia A

Science.gov (United States)

Mahlangu, Johnny; Kuliczkowski, Kazimierz; Karim, Faraizah Abdul; Stasyshyn, Oleksandra; Kosinova, Marina V.; Lepatan, Lynda Mae; Skotnicki, Aleksander; Boggio, Lisa N.; Klamroth, Robert; Oldenburg, Johannes; Hellmann, Andrzej; Santagostino, Elena; Baker, Ross I.; Fischer, Kathelijn; Gill, Joan C.; P’Ng, Stephanie; Chowdary, Pratima; Escobar, Miguel A.; Khayat, Claudia Djambas; Rusen, Luminita; Bensen-Kennedy, Debra; Blackman, Nicole; Limsakun, Tharin; Veldman, Alex; St. Ledger, Katie

2016-01-01

Recombinant VIII (rVIII)-SingleChain is a novel B-domain–truncated recombinant factor VIII (rFVIII), comprised of covalently bonded factor VIII (FVIII) heavy and light chains. It was designed to have a higher binding affinity for von Willebrand factor (VWF). This phase 1/3 study investigated the efficacy and safety of rVIII-SingleChain in the treatment of bleeding episodes, routine prophylaxis, and surgical prophylaxis. Participants were ≥12 years of age, with severe hemophilia A (endogenous FVIII <1%). The participants were allocated by the investigator to receive rVIII-SingleChain in either an on-demand or prophylaxis regimen. Of the 175 patients meeting study eligibility criteria, 173 were treated with rVIII-SingleChain, prophylactically (N = 146) or on-demand (N = 27). The total cumulative exposure was 14 306 exposure days (EDs), with 120 participants reaching ≥50 EDs and 52 participants having ≥100 EDs. Hemostatic efficacy was rated by the investigator as excellent or good in 93.8% of the 835 bleeds treated and assessed. Across all prophylaxis regimens, the median annualized spontaneous bleeding rate was 0.00 (Q1, Q3: 0.0, 2.4) and the median overall annualized bleeding rate (ABR) was 1.14 (Q1, Q3: 0.0, 4.2). Surgical hemostasis was rated as excellent/good in 100% of major surgeries by the investigator. No participant developed FVIII inhibitors. In conclusion, rVIII-SingleChain is a novel rFVIII molecule showing excellent hemostatic efficacy in surgery and in the control of bleeding events, low ABR in patients on prophylaxis, and a favorable safety profile in this large clinical study. This trial was registered at www.clinicaltrials.gov as #NCT01486927. PMID:27330001

World Energy Data System (WENDS). Volume VII. Nuclear facility profiles, AG--CH. [Brief tabulated information

Energy Technology Data Exchange (ETDEWEB)

1979-06-01

In this compendium each profile of a nuclear facility is a capsule summary of pertinent facts regarding that particular installation. The facilities described include the entire fuel cycle in the broadest sense, encompassing resource recovery through waste management. Power plants and all US facilities have been excluded. To facilitate comparison the profiles have been recorded in a standard format. Because of the breadth of the undertaking some data fields do not apply to the establishment under discussion and accordingly are blank. The set of nuclear facility profiles occupies four volumes; the profiles are ordered by country name, and then by facility code. Each nuclear facility profile volume contains two complete indexes to the information. The first index aggregates the facilities alphabetically by country. It is further organized by category of facility, and then by the four-character facility code. It provides a quick summary of the nuclear energy capability or interest in each country and also an identifier, the facility code, which can be used to access the information contained in the profile.

World Energy Data System (WENDS). Volume IX. Nuclear facility profiles, IN--PL. [Brief tabulated information

Energy Technology Data Exchange (ETDEWEB)

1979-06-01

In this compendium each profile of a nuclear facility is a capsule summary of pertinent facts regarding that particular installation. The facilities described include the entire fuel cycle in the broadest sense, encompassing resource recovery through waste management. Power plants and all US facilities have been excluded. To facilitate comparison the profiles have been recorded in a standard format. Because of the breadth of the undertaking some data fields do not apply to the establishment under discussion and accordingly are blank. The set of nuclear facility profiles occupies four volumes; the profiles are ordered by country name, and then by facility code. Each nuclear facility profile volume contains two complete indexes to the information. The first index aggregates the facilities alphabetically by country. It is further organized by category of facility, and then by the four-character facility code. It provides a quick summary of the nuclear energy capability or interest in each country and also an identifier, the facility code, which can be used to access the information contained in the profile.

World Energy Data System (WENDS). Volume X. Nuclear facility profiles, PO--ZA. [Brief tabulated information

Energy Technology Data Exchange (ETDEWEB)

1979-06-01

In this compendium each profile of a nuclear facility is a capsule summary of pertinent facts regarding that particular installation. The facilities described include the entire fuel cycle in the broadest sense, encompassing resource recovery through waste management. Power plants and all US facilities have been excluded. To facilitate comparison the profiles have been recorded in a standard format. Because of the breadth of the undertaking some data fields do not apply to the establishment under discussion and accordingly are blank. The set of nuclear facility profiles occupies four volumes; the profiles are ordered by country name, and then by facility code. Each nuclear facility profile volume contains two complete indexes to the information. The first index aggregates the facilities alphabetically by country. It is further organized by category of facility, and then by the four-character facility code. It provides a quick summary of the nuclear energy capability or interest in each country and also an identifier, the facility code, which can be used to access the information contained in the profile.

Recommendations for a Department of Energy Nuclear Energy R and D Agenda Volume 2 Appendices

International Nuclear Information System (INIS)

1997-01-01

The current US nuclear energy policy is primarily formulated as part of the nation's overall energy policy. In addition, nuclear energy policy is impacted by other US policies, such as those for defense and environment, and by international obligations through their effects on nuclear weapons dismantlement and stewardship, continued reliance on space and naval nuclear power sources, defense waste cleanup, and on nuclear nonproliferation. This volume is composed of the following appendices: Appendix 1--Objectives of the Federal Government Nuclear Energy Related Policies and Research and Development Programs; Appendix 2--Nuclear Energy and Related R and D in the US; Appendix 3--Summary of Issues That Drive Nuclear Energy Research and Development; Appendix 4: Options for Policy and Research and Development; Appendix 5--Pros and Cons of Objectives and Options; and Appendices 6--Recommendations

Recommendations for a Department of Energy Nuclear Energy R and D Agenda Volume 2 Appendices

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-12-01

The current US nuclear energy policy is primarily formulated as part of the nation`s overall energy policy. In addition, nuclear energy policy is impacted by other US policies, such as those for defense and environment, and by international obligations through their effects on nuclear weapons dismantlement and stewardship, continued reliance on space and naval nuclear power sources, defense waste cleanup, and on nuclear nonproliferation. This volume is composed of the following appendices: Appendix 1--Objectives of the Federal Government Nuclear Energy Related Policies and Research and Development Programs; Appendix 2--Nuclear Energy and Related R and D in the US; Appendix 3--Summary of Issues That Drive Nuclear Energy Research and Development; Appendix 4: Options for Policy and Research and Development; Appendix 5--Pros and Cons of Objectives and Options; and Appendices 6--Recommendations.

Research program for seismic qualification of nuclear plant electrical and mechanical equipment. Task 4. Use of fragility in seismic design of nuclear plant equipment. Volume 4

International Nuclear Information System (INIS)

Kana, D.D.; Pomerening, D.J.

1984-08-01

The Research Program for Seismic Qualification of Nuclear Plant Electrical and Mechanical Equipment has spanned a period of three years and resulted in seven technical summary reports, each of which have covered in detail the findings of different tasks and subtasks, and have been combined into five NUREG/CR volumes. Volume 4 presents study of the use of fragility concepts in the design of nuclear plant equipment and compares the results of state-of-the-art proof testing with fragility testing

Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume VII. International perspectives

Energy Technology Data Exchange (ETDEWEB)

1980-06-01

The purpose of this volume is to assess the proliferation vulnerabilities of the present deployment of civilian nuclear-power systems within the current nonproliferation regime and, in light of their prospective deployment, to consider technical and institutional measures and alternatives which may contribute to an improved regime in which nuclear power could play a significant part. An assessment of these measures must include consideration of their nonproliferation effectiveness as well as their bearing upon energy security, and their operational, economic, and political implications. The nature of these considerations can provide some measure of their likely acceptability to various nations.

Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume VII. International perspectives

International Nuclear Information System (INIS)

1980-06-01

The purpose of this volume is to assess the proliferation vulnerabilities of the present deployment of civilian nuclear-power systems within the current nonproliferation regime and, in light of their prospective deployment, to consider technical and institutional measures and alternatives which may contribute to an improved regime in which nuclear power could play a significant part. An assessment of these measures must include consideration of their nonproliferation effectiveness as well as their bearing upon energy security, and their operational, economic, and political implications. The nature of these considerations can provide some measure of their likely acceptability to various nations

Nuclear Power Options Viability Study. Volume 3. Nuclear discipline topics

Energy Technology Data Exchange (ETDEWEB)

Trauger, D B; White, J D; Bowers, H I; Braid, R B; Cantor, R A; Daniels, L; Davis, R M; Delene, J G; Gat, U; Hood, T C

1986-09-01

Innovative reactor concepts are described and evaluated in accordance with criteria established in the study. The reactors to be studied were chosen on the basis of three ground rules: (1) the potential for commercialization between 2000-2010, (2) economic competiveness with coal-fired plants, and (3) the degree of passive safety in the design. The concepts, classified by coolants, were light water reactors, liquid metal reactors, and high temperature reactors, and most were of modular design. All the concepts appear to be potentially viable in the time frame selected, but the information available is not adequate for a definitive evaluation of their economic competitiveness. This volume primarily reports in greater detail on several topics from the study. These are: Construction, Economics, Regulation, Safety and Economic Risk, Nuclear Waste Transportation and Disposal, and Market Acceptance. Although treated generically, the topics are presented in the context of the reactor concepts of the study.

Nuclear Power Options Viability Study. Volume 3. Nuclear discipline topics

International Nuclear Information System (INIS)

Trauger, D.B.; White, J.D.; Bowers, H.I.

1986-09-01

Innovative reactor concepts are described and evaluated in accordance with criteria established in the study. The reactors to be studied were chosen on the basis of three ground rules: (1) the potential for commercialization between 2000-2010, (2) economic competiveness with coal-fired plants, and (3) the degree of passive safety in the design. The concepts, classified by coolants, were light water reactors, liquid metal reactors, and high temperature reactors, and most were of modular design. All the concepts appear to be potentially viable in the time frame selected, but the information available is not adequate for a definitive evaluation of their economic competitiveness. This volume primarily reports in greater detail on several topics from the study. These are: Construction, Economics, Regulation, Safety and Economic Risk, Nuclear Waste Transportation and Disposal, and Market Acceptance. Although treated generically, the topics are presented in the context of the reactor concepts of the study

Role of VI/II ratio on the growth of ZnO nanostructures using chemical bath deposition

Energy Technology Data Exchange (ETDEWEB)

Urgessa, Z.N., E-mail: zelalem.urgessa@nmmu.ac.za [Department of Physics, P.O. Box 77000, Nelson Mandela Metropolitan University, Port Elizabeth 6031 (South Africa); Oluwafemi, O.S. [Department of Chemistry and Chemical Technology, Walter Sisulu University, Mthatha Campus, Private Bag XI, 5117 (South Africa); Botha, J.R. [Department of Physics, P.O. Box 77000, Nelson Mandela Metropolitan University, Port Elizabeth 6031 (South Africa)

2012-05-15

In this paper the growth process and morphological evolution of ZnO nanostructures were investigated in a series of experiments using chemical bath deposition. The experimental results indicate that the morphological evolution depends on the reaction conditions, particularly on OH{sup -} to Zn{sup 2+} ratio (which directly affects the pH). For low VI/II ratios, quasi-spherical nanoparticles of an average diameter 30 nm are obtained, whereas for larger VI/II ratios, nanorods with an average diameter less than 100 nm are produced, which indicates that by systematically controlling the VI/II ratio, it is possible to produce different shapes and sizes of ZnO nanostructures. A possible mechanism for the nanostructural change of the as-synthesized ZnO from particle to rod was elucidated based on the relative densities of H{sup +} and OH{sup -} in the solution.

Role of VI/II ratio on the growth of ZnO nanostructures using chemical bath deposition

International Nuclear Information System (INIS)

Urgessa, Z.N.; Oluwafemi, O.S.; Botha, J.R.

2012-01-01

In this paper the growth process and morphological evolution of ZnO nanostructures were investigated in a series of experiments using chemical bath deposition. The experimental results indicate that the morphological evolution depends on the reaction conditions, particularly on OH − to Zn 2+ ratio (which directly affects the pH). For low VI/II ratios, quasi-spherical nanoparticles of an average diameter 30 nm are obtained, whereas for larger VI/II ratios, nanorods with an average diameter less than 100 nm are produced, which indicates that by systematically controlling the VI/II ratio, it is possible to produce different shapes and sizes of ZnO nanostructures. A possible mechanism for the nanostructural change of the as-synthesized ZnO from particle to rod was elucidated based on the relative densities of H + and OH − in the solution.

PENGEMBANGAN KARAKTER KEDISIPLINAN DAN KEMAMPUAN PEMECAHAN MASALAH MELALUI MODEL LAPS-HEURISTIK MATERI LINGKARAN KELAS-VIII

Directory of Open Access Journals (Sweden)

Sri Wahyuni

2015-08-01

Full Text Available Tujuan penelitian ini adalah untuk mengetahui (1 apakah pembelajaran dengan model pembelajaran LAPS-Heuristik pada materi lingkaran kelas-VIII dapat mengembangkan karakter kedisiplinan peserta didik, (2 apakah pembelajaran dengan model pembelajaran LAPS-Heuristik pada materi lingkaran kelas-VIII dapat meningkatkan kemampuan pemecahan masalah peserta didik, (3 apakah kemampuan pemecahan masalah matematika peserta didik yang diajar dengan model pembelajaran LAPS-Heuristik pada materi lingkaran kelas-VIII dapat mencapai kriteria ketuntasan minimal yang ditentukan. Desain penelitian ini adalah kualitatif deskriptif, artinya menggambarkan atau mendeskripsikan kejadian-kejadian yang menjadi pusat perhatian secara kualitatif dan berdasar data kualitatif. Penentuan sumber data dalam penelitian ini menggunakan teknik purposive sampling, yaitu dipilih dengan pertimbangan dan tujuan tertentu. Data diperoleh dengan observasi, wawancara, dan tes yang kemudian dianalisis menggunakan analisis kualitatif dan analisis gain untuk mengukur peningkatan. Analisis kualitatif menunjukkan karakter kedisiplinan dan kemampuan pemecahan masalah peserta didik meningkat, serta kemampuan pemecahan masalah peserta didik mencapai KKM melalui model pembelajaran LAPS-Heuristik.

Hanford spent nuclear fuel project recommended path forward, volume III: Alternatives and path forward evaluation supporting documentation

International Nuclear Information System (INIS)

Fulton, J.C.

1994-10-01

Volume I of the Hanford Spent Nuclear Fuel Project - Recommended Path Forward constitutes an aggressive series of projects to construct and operate systems and facilities to safely retrieve, package, transport, process, and store K Basins fuel and sludge. Volume II provided a comparative evaluation of four Alternatives for the Path Forward and an evaluation for the Recommended Path Forward. Although Volume II contained extensive appendices, six supporting documents have been compiled in Volume III to provide additional background for Volume II

Chromosome VIII disomy influences the nonsense suppression efficiency and transition metal tolerance of the yeast Saccharomyces cerevisiae.

Science.gov (United States)

Zadorsky, S P; Sopova, Y V; Andreichuk, D Y; Startsev, V A; Medvedeva, V P; Inge-Vechtomov, S G

2015-06-01

The SUP35 gene of the yeast Saccharomyces cerevisiae encodes the translation termination factor eRF3. Mutations in this gene lead to the suppression of nonsense mutations and a number of other pleiotropic phenotypes, one of which is impaired chromosome segregation during cell division. Similar effects result from replacing the S. cerevisiae SUP35 gene with its orthologues. A number of genetic and epigenetic changes that occur in the sup35 background result in partial compensation for this suppressor effect. In this study we showed that in S. cerevisiae strains in which the SUP35 orthologue from the yeast Pichia methanolica replaces the S. cerevisiae SUP35 gene, chromosome VIII disomy results in decreased efficiency of nonsense suppression. This antisuppressor effect is not associated with decreased stop codon read-through. We identified SBP1, a gene that localizes to chromosome VIII, as a dosage-dependent antisuppressor that strongly contributes to the overall antisuppressor effect of chromosome VIII disomy. Disomy of chromosome VIII also leads to a change in the yeast strains' tolerance of a number of transition metal salts. Copyright © 2015 John Wiley & Sons, Ltd.

Fourth DOE Natural Phenomena Hazards Mitigation Conference: Proceedings. Volume 1

Energy Technology Data Exchange (ETDEWEB)

1993-12-31

This conference allowed an interchange in the natural phenomena area among designers, safety professionals, and managers. The papers presented in Volume I of the proceedings are from sessions I - VIII which cover the general topics of: DOE standards, lessons learned and walkdowns, wind, waste tanks, ground motion, testing and materials, probabilistic seismic hazards, risk assessment, base isolation and energy dissipation, and lifelines and floods. Individual papers are indexed separately. (GH)

Progress toward inducing immunologic tolerance to factor VIII

OpenAIRE

Scott, David W.; Pratt, Kathleen P.; Miao, Carol H.

2013-01-01

A major problem in treating hemophilia A patients with therapeutic factor VIII (FVIII) is that 20% to 30% of these patients produce neutralizing anti-FVIII antibodies. These antibodies block (inhibit) the procoagulant function of FVIII and thus are termed “inhibitors.” The currently accepted clinical method to attempt to eliminate inhibitors is immune tolerance induction (ITI) via a protocol requiring intensive FVIII treatment until inhibitor titers drop. Although often successful, ITI is ext...

Second interim assessment of the Canadian concept for nuclear fuel waste disposal. Volume 2

International Nuclear Information System (INIS)

Gillespie, P.A.; Wuschke, D.M.; Guvanasen, V.M.; Mehta, K.K.; McConnell, D.B.; Tamm, J.A.; Lyon, R.B.

1985-12-01

The nuclear fuel waste disposal concept chosen for development and assessment in Canada involves the burial of corrosion-resistant containers of waste in a vault located deep in plutonic rock in the Canadian Shield. As the concept and the assessment tools are developed, periodic assessments are performed to permit evaluatin of the methodology and provide feedback to those developing the concept. The ultimate goal of these assessments is to predict what impact the disposal system would have if the concept were implemented. The second assessment was performed in 1984 and is documented in Second Interim Assessment of the Canadian Concept for Nuclear Fuel Waste Disposal - Volumes 1 to 4. This volume, entitled Background, discusses Canadian nuclear fuel wastes and the desirable features of a waste disposal method. It outlines several disposal options being considered by a number of countries, including the option chosen for development and assessment in Canada. The reference disposal systems assumed for the second assessment are described, and the approach used for concept assessment is discussed briefly. 79 refs

Fluid-phase immunoradiometric assay for the detection of qualitative abnormalities of factor VIII/von Willebrand factor in variants of von Willebrand's disease

International Nuclear Information System (INIS)

Girma, J.P.; Ardaillou, N.; Meyer, D.; Lavergne, J.M.; Larrieu, M.J.

1979-01-01

Antigenic reactivity of F.VIII/WF in variants of von Willebrand's disease (vWd) was studied with both fluid-phase and solid-phase immunoradiometric assays. Two different (rabbit and goat) 125 I-labeled specific antibodies against purified F.VIII/WF were used in both their divalent (lgG) and their monovalent (Fab fragment) forms. Dose-response curves obtained by reacting a constant amount of antibody with serial dilutions of plasmas from normal or homozygous vWd demonstrated the specificity of the test. The accuracy was significantly higher with 125 I-Fab fragments of goat anti-F.VIII/WF antiserum than intact goat lgG or rabbit lgG or Fab fragments. The significant decrease of the slope of the dose-response curves obtained with plasma from variants of vWd has been interpreted as due to the presence of abnormal F.VIII/WF molecules with decreased antigenic reactivity. A similar anomaly was found in cryosupernatant prepared from normal plasma, paralleling similarities demonstrated between variants of vWd and cryosupernatant. Results of experiments performed by reacting constant plasma dilutions from control or variants of vWd and varying concentrations of anti-F.VIII/WF Fab fragments (rabbit or goat) confirmed the decreased antigenic reactivity of variant F.VIII/WF

Glioneuronal Heterotopia Presenting As a Cerebellopontine angle Tumor of the cranial Nerve VIII, Case Report.

Science.gov (United States)

Peris-Celda, M; Giannini, C; Diehn, F E; Eckel, L J; Neff, B A; Van Gompel, J J

2018-04-03

Vestibular schwannomas and meningiomas account for the great majority of lesions arising in the cerebellopontine angle (CPA). In this report, we present a case of glioneuronal heterotopia, also known as glioneuronal hamartoma, arising from the VIII cranial nerve, which is an extremely uncommon lesion. Important radiologic and surgical aspects are reviewed, which may help in early recognition and intraoperative decision making when these lesions are encountered. A healthy 29-year-old female presented with intermittent right facial numbness. Magnetic resonance imaging (MRI) showed an incidental minimally enhancing cerebellopontine angle lesion on the right VII-VIII cranial nerve complex. The patient declined serial observation and opted for operative intervention for resection. Intraoperatively, the lesion resembled neural tissue and was continuous with the VIII cranial nerve. Pathological analysis demonstrated mature glioneuronal tissue consistent with hamartomatous brain tissue. The patient maintained normal hearing and facial nerve function after surgery. Radiologic, surgical and pathological characteristics are described. Ectopic glioneuronal tissue of the VIII cranial nerve is a rare non-neoplastic lesion, and should be considered in the differential diagnosis of unusual appearing intracanalicular and cerebellopontine angle lesions. The congenital and benign nature of this entity makes observation a valid option for these cases, although they are so infrequent that they are often presumptively managed as vestibular schwannomas. Attempts to radically resect these lesions may result in higher rates of hearing loss or facial palsy due to their continuity with the cranial nerves. Copyright © 2018 Elsevier Inc. All rights reserved.

Characterization of a thrombin cleavage site mutation (Arg 1689 to Cys) in the factor VIII gene of two unrelated patients with cross-reacting material-positive hemophilia A.

Science.gov (United States)

Arai, M; Higuchi, M; Antonarakis, S E; Kazazian, H H; Phillips, J A; Janco, R L; Hoyer, L W

1990-01-15

The molecular defect responsible for moderate and severe hemophilia A has been identified for two unrelated patients with the CRM-positive form of this disorder (factor VIII activity of 0.02 and 0.05 U/mL with factor VIII antigen of 0.87 and 2.20 U/mL). In both cases, the immunopurified dysfunctional factor VIII protein is abnormal, in that the 80 Kd light chain is not cleaved by thrombin at arginine-1689. The basis for this failure was identified by polymerase chain reaction amplification of exon 14 of the variant factor VIII genes and direct sequencing of the amplified products. In both cases, a single base substitution (C to T) was identified that produces an arginine to cysteine substitution at amino acid residue 1689. These data identify the molecular defects of the two identical factor VIII variant proteins. The dysfunctional factor VIII has been designated "Factor VIII-East Hartford," the residence of the patient in whom the defect was first identified.

Lacerations to Zones VIII and IX: It Is Not Just a Tendon Injury

Directory of Open Access Journals (Sweden)

Charla R. Fischer

2011-01-01

Full Text Available Extensor tendon injuries are widely believed to be straightforward problems that are relatively simple to manage. However, these injuries can be complex and demand a thorough understanding of anatomy to achieve the best functional outcomes. When lacerations occur in the forearm as in Zones VIII and IX injury, the repair of the extensor tendon and muscle, and posterior interosseous nerve (PIN is often challenging. A review of the literature shows little guidance and attention for these injuries. We present four patients with injuries to Zones VIII and IX as well as a review of surgical technique, postoperative rehabilitation, and pearls that may be of benefit to those managing these injuries.

Using electrochemical separation to reduce the volume of high-level nuclear waste

International Nuclear Information System (INIS)

Slater, S.A.; Gay, E.C.

1998-01-01

Argonne National Laboratory (ANL) has developed an electrochemical separation technique called electrorefining that will treat a variety of metallic spent nuclear fuel and reduce the volume of high-level nuclear waste that requires disposal. As part of that effort, ANL has developed a high throughput electrorefiner (HTER) that has a transport rate approximately three times faster than electrorefiners previously developed at ANL. This higher rate is due to the higher electrode surface area, a shorter transport path, and more efficient mixing, which leads to smaller boundary layers about the electrodes. This higher throughput makes electrorefining an attractive option in treating Department of Energy spent nuclear fuels. Experiments have been done to characterize the HTER, and a simulant metallic fuel has been successfully treated. The HTER design and experimental results is discussed

The NJOY nuclear data processing system: Volume 2, The NJOY, RECONR, BROADR, HEATR, and THERMR modules

International Nuclear Information System (INIS)

MacFarlane, R.E.; Muir, D.W.; Boicourt, R.M.

1982-05-01

The NJOY nuclear data processing system is a comprehensive computer code package for producing cross sections and related nuclear parameters from ENDF/B evaluated nuclear data. This volume provides detailed descriptions of the NJOY module, which contains the executive program and utility subroutines used by the other modules, and it discusses the theory and computational methods of four of the modules used for producing pointwise cross sections: RECONR, BROADR, HEATR, and THERMR

Volumes, Masses, and Surface Areas for Shippingport LWBR Spent Nuclear Fuel in a DOE SNF Canister

International Nuclear Information System (INIS)

J.W. Davis

1999-01-01

The purpose of this calculation is to estimate volumes, masses, and surface areas associated with (a) an empty Department of Energy (DOE) 18-inch diameter, 15-ft long spent nuclear fuel (SNF) canister, (b) an empty DOE 24-inch diameter, 15-ft long SNF canister, (c) Shippingport Light Water Breeder Reactor (LWBR) SNF, and (d) the internal basket structure for the 18-in. canister that has been designed specifically to accommodate Seed fuel from the Shippingport LWBR. Estimates of volumes, masses, and surface areas are needed as input to structural, thermal, geochemical, nuclear criticality, and radiation shielding calculations to ensure the viability of the proposed disposal configuration

PENGARUH KEMANDIRIAN BELAJAR DAN PENGGUNAAN UANG SAKU TERHADAP PRESTASI BELAJAR KOMPETENSI DASAR EKONOMI KELAS VII DAN VIII

OpenAIRE

Apri Dwi Astuti

2012-01-01

Kemandirian belajar membantu siswa untuk bertanggung jawab dan menumbuhkan kesadaran belajar. Penggunaan uang saku menumbuhkan jiwa mandiri, jujur dan komitmen. Adapun hasil observasi awal menunjukkan masih ada siswa kels VII dan VIII SMP Semesta untuk kompetensi dasar ekonomi dibawah KKM. Tujuan penelitian ini untuk mengetahui pengaruh kemandirian belajar dn penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta. Populasi penelitian ini adalah ...

Estudos sobre a regeneração do figado - variação do volume nuclear das celulas hepáticas em repouso divisional

Directory of Open Access Journals (Sweden)

Fernando Ubatuba

1948-12-01

Full Text Available Surgical removal of large amounts of hepatic tissue in male albino rats results in a rapid and conspicuous raise in cellular nuclear volumes. Measurements were made exclusively in resting nuclei. This volume variation is transitory. Nuclear volumes return to the normal value withins 6 days of restoration. The higher value are abserved 48 hours after the hepatic removal, indicating probably that this effect is due to hydration of the nucei, as occurs in the cytoplasm. This hydration could be correlated to the mitotic activity of the renmant tissue since a peak of mitoses parallels the changes in the nuclear volumes.

Estudo citofotométrico da expressão do marcador tumoral Fator VIII e fatores prognósticos no adenocarcinoma gástrico Cytophotometric study of the expression of the tumoral marker Factor VIII and prognostic factors in gastrci adenocarcinoma

Directory of Open Access Journals (Sweden)

Mary Tossa Nakamura

2007-12-01

Full Text Available RACIONAL: No câncer gástrico, a incidência, o diagnóstico e as opções terapêuticas apresentaram melhorias nas últimas décadas, porém o prognóstico permanece reservado, especialmente devido à maioria dos pacientes procurarem recurso médico com tumores avançados, metastáticos ou cirurgicamente irressecáveis já no diagnóstico. Biologia molecular é área de conhecimento recente com grandes questionamentos a serem respondidos e a atualidade dos fatos científicos mostra que o caminho deverá ser através da identificação de marcadores tumorais. Os grandes avanços na área da informática aprimoraram a análise da imagem celular através da citofotometria de imagem que possibilita através da imunoistoquímica estudar a proliferação celular e a angiogênese que participa em diversos processos tumorais, sendo pesquisadas por vários marcadores. Atualmente estudos são realizados para demonstrar o valor prognóstico de suas expressões, contudo, no adenocarcinoma gástrico resultados têm sido divergentes e estudos escassos. OBJETIVOS: Identificar e quantificar citofotometricamente a expressão dos marcadores da angiogênese através do fator VIII no adenocarcinoma e comparar suas expressões com fa classificação de Bormann, profundidade de invasão tumoral, grau de diferenciação, envolvimento nodal, padrão histológico e idade. MÉTODOS: Foram estudados 21 pacientes com adenocarcinoma gástrico, identificados de 1998 a 2006. Para a detecção do Fator VIII foi realizada imunoistoquímica, com anticorpo policlonal para Fator VIII. Foi realizada análise citofotométrica informatizada pelo sistema SAMBA 4000. RESULTADOS: Dos 21 pacientes 61,90% eram do sexo masculino e 38,10% do feminino, com idade mediana de 65 anos e apenas um não marcou para o Fator VIII (95,24% de marcação. As médias dos índices de marcagem para o Fator VIII foram de 61,14% (desvio-padrão de 15,06, variando de 29,16 a 73,91. Tumores com classifica

Application of Nuclear Volume Measurements to Comprehend the Cell Cycle in Root-Knot Nematode-Induced Giant Cells

Directory of Open Access Journals (Sweden)

José Dijair Antonino de Souza Junior

2017-06-01

Full Text Available Root-knot nematodes induce galls that contain giant-feeding cells harboring multiple enlarged nuclei within the roots of host plants. It is recognized that the cell cycle plays an essential role in the set-up of a peculiar nuclear organization that seemingly steers nematode feeding site induction and development. Functional studies of a large set of cell cycle genes in transgenic lines of the model host Arabidopsis thaliana have contributed to better understand the role of the cell cycle components and their implication in the establishment of functional galls. Mitotic activity mainly occurs during the initial stages of gall development and is followed by an intense endoreduplication phase imperative to produce giant-feeding cells, essential to form vigorous galls. Transgenic lines overexpressing particular cell cycle genes can provoke severe nuclei phenotype changes mainly at later stages of feeding site development. This can result in chaotic nuclear phenotypes affecting their volume. These aberrant nuclear organizations are hampering gall development and nematode maturation. Herein we report on two nuclear volume assessment methods which provide information on the complex changes occurring in nuclei during giant cell development. Although we observed that the data obtained with AMIRA tend to be more detailed than Volumest (Image J, both approaches proved to be highly versatile, allowing to access 3D morphological changes in nuclei of complex tissues and organs. The protocol presented here is based on standard confocal optical sectioning and 3-D image analysis and can be applied to study any volume and shape of cellular organelles in various complex biological specimens. Our results suggest that an increase in giant cell nuclear volume is not solely linked to increasing ploidy levels, but might result from the accumulation of mitotic defects.

Factor VIII and von Willebrand factor co-delivery by endothelial cells

NARCIS (Netherlands)

Bouwens, E.A.M.|info:eu-repo/dai/nl/314061894

2011-01-01

A defect in coagulation factor VIII (FVIII) results in the inherited bleeding disorder hemophilia A. Current treatment of hemophilia A is hampered by the need of frequent administration of costly FVIII products. Therefore gene therapy is an attractive alternative for protein replacement to treat

Historical intensity VIII earthquakes along the Rhone valley (Valais, Switzerland): primary and secondary effects

Energy Technology Data Exchange (ETDEWEB)

Fritsche, S.; Faeh, D.; Schwarz-Zanetti, G.

2012-06-15

In recent years the upper Rhone Valley has been one of the most intensively investigated regions by the Swiss Seismological Service. The high seismicity in the region encourages research in the seismological field and one main focus has been historical seismology. This report presents the state of the art of our historical investigations by giving an overview of the effects of four damaging earthquakes with intensity larger than VII, for which a fairly large number of documents could be found and analyzed. The overview includes the events of 1584 (Aigle, epicentral intensity VIII), 1755 (Brig, epicentral intensity VIII), 1855 (Visp, epicentral intensity VIII), and 1946 (Sierre, epicentral intensity VIII for the main shock and intensity VII for the largest aftershock). The paper focuses mainly on primary and secondary effects in the epicentral region, providing the key data and a general characterization of the event. Generally, primary effects such as the reaction of the population and impact on buildings took more focus in the past. Thus building damage is more frequently described in historic documents. However, we also found a number of sources describing secondary effects such as landslides, snow avalanches, and liquefaction. Since the sources may be useful, we include citations of these documents. The 1584 Aigle event, for example, produced exceptional movements in the Lake of Geneva, which can be explained by an expanded sub aquatic slide with resultant tsunami and seiche. The strongest of the aftershocks of the 1584 event triggered a destructive landslide covering the villages Corbeyrier and Yvorne, Vaud. All macroseismic data on the discussed events are accessible through the web page of the Swiss Seismological Service (http://www.seismo.ethz.ch). (authors)

Analysis of some nuclear waste management options. Volume II. Appendices

International Nuclear Information System (INIS)

Berman, L.E.; Ensminger, D.A.; Giuffre, M.S.; Koplik, C.M.; Oston, S.G.; Pollak, G.D.; Ross, B.I.

1978-01-01

This report describes risk analyses performed on that portion of a nuclear fuel cycle which begins following solidification of high-level waste. Risks associated with handling, interim storage and transportation of the waste are assessed, as well as the long term implications of disposal in deep mined cavities. The risk is expressed in terms of expected dose to the general population and peak dose to individuals in the population. This volume consists of appendices which provide technical details of the work performed

Analysis of some nuclear waste management options. Volume II. Appendices

Energy Technology Data Exchange (ETDEWEB)

Berman, L.E.; Ensminger, D.A.; Giuffre, M.S.; Koplik, C.M.; Oston, S.G.; Pollak, G.D.; Ross, B.I.

1978-10-10

This report describes risk analyses performed on that portion of a nuclear fuel cycle which begins following solidification of high-level waste. Risks associated with handling, interim storage and transportation of the waste are assessed, as well as the long term implications of disposal in deep mined cavities. The risk is expressed in terms of expected dose to the general population and peak dose to individuals in the population. This volume consists of appendices which provide technical details of the work performed.

Design data and safety features of commercial nuclear power plants including cumulative index for Volumes I--VI

International Nuclear Information System (INIS)

Heddleson, F.A.

1977-01-01

Design data, safety features, and site characteristics are summarized for 12 nuclear power units in 6 power stations in the United States. Six pages of data are presented for each station, consisting of thermal-hydraulic and nuclear factors, containment features, emergency-core-cooling systems, site features, circulating water system data, and miscellaneous factors. In addition, an aerial perspective is presented for each plant. This volume covers plants with docket numbers 50-553 through 50-569 (Phipps Bend, Black Fox, Yellow Creek, and NEP) and two earlier plants not previously reported--Hope Creek (50-354, 50-355) and WPPSS 1 and 4 (50-460, 50-513). Indexes for this volume and the five earlier volumes are presented in three forms--by docket number, by plant name, and by participating utility

Naval Medical Research And Development News. Volume 8, Issue 4, April 2016

Science.gov (United States)

2016-04-01

1 Volume VIII, Issue 4 April 2016 In this issue... Use your smartphone to access our website! NMR&D News is an authorized publication of the Naval...prevention and rehabilitation, fatigue and sleep performance, and environmental physiology. “Our team at NHRC is comprised of experts in biomedical...limits of healthy warfighters ~ Evaluate new technologies for enhancing performance and reducing injuries ~ Support sleep optimization and fatigue

Nuclear Computerized Library for Assessing Reactor Reliability (NUCLARR): Volume 1, Summary description

International Nuclear Information System (INIS)

Gertman, D.I.; Gilmore, W.E.; Galyean, W.J.; Groh, M.R.; Gentillon, C.D.; Gilbert, B.G.

1988-02-01

A data management system has been implemented which supports a variety of risk-related analyses and provides a repository of hardware component failure and human error probability data to the risk analyst. The Nuclear Computerized Library for Assessing Reactor Reliability, NUCLARR, is an interactive, graphically oriented system which resides on a personal computer (PC) or PC-compatible environment. An overview of the data management system, including a description of data collection, specification, data structure, and taxonomies, is presented in Volume I of this report. Programming activities, procedures for processing data, user's guide, and hard copy data manual are presented in Volumes II through V

Proceedings of the 1984 DOE nuclear reactor and facility safety conference. Volume II

Energy Technology Data Exchange (ETDEWEB)

1984-01-01

This report is a collection of papers on reactor safety. The report takes the form of proceedings from the 1984 DOE Nuclear Reactor and Facility Safety Conference, Volume II of two. These proceedings cover Safety, Accidents, Training, Task/Job Analysis, Robotics and the Engineering Aspects of Man/Safety interfaces.

Proceedings of the 1984 DOE nuclear reactor and facility safety conference. Volume II

International Nuclear Information System (INIS)

1984-01-01

This report is a collection of papers on reactor safety. The report takes the form of proceedings from the 1984 DOE Nuclear Reactor and Facility Safety Conference, Volume II of two. These proceedings cover Safety, Accidents, Training, Task/Job Analysis, Robotics and the Engineering Aspects of Man/Safety interfaces

Effects of Mg/Ga and V/III source ratios on hole concentration of N-polar (000\\bar{1}) p-type GaN grown by metalorganic vapor phase epitaxy

Science.gov (United States)

Nonoda, Ryohei; Shojiki, Kanako; Tanikawa, Tomoyuki; Kuboya, Shigeyuki; Katayama, Ryuji; Matsuoka, Takashi

2016-05-01

The effects of growth conditions such as Mg/Ga and V/III ratios on the properties of N-polar (000\\bar{1}) p-type GaN grown by metalorganic vapor phase epitaxy were studied. Photoluminescence spectra from Mg-doped GaN depended on Mg/Ga and V/III ratios. For the lightly doped samples, the band-to-acceptor emission was observed at 3.3 eV and its relative intensity decreased with increasing V/III ratio. For the heavily doped samples, the donor-acceptor pair emission was observed at 2.8 eV and its peak intensity monotonically decreased with V/III ratio. The hole concentration was maximum for the Mg/Ga ratio. This is the same tendency as in group-III polar (0001) growth. The V/III ratio also reduced the hole concentration. The higher V/III ratio reduced the concentration of residual donors such as oxygen by substituting nitrogen atoms. The surface became rougher with increasing V/III ratio and the hillock density increased.

Idiopathic factor VIII inhibitor autoantibody in a man presented after accident.

NARCIS (Netherlands)

Mansouritorghabeh, H.; Lak, M.; Heerde, W.L. van

2009-01-01

Acquired hemophilia A is a rare but severe autoimmune bleeding disorder caused by autoantibodies against factor VIII activity and is a potentially life-threatening hemorrhagic disorder. The incidence of acquired hemophilia A has been estimated as 1.48 cases per million per year. The overall rate of

Comprehensive Cooling Water Study. Volume 1. Summary of environmental effects, Savannah River Plant. Annual report

International Nuclear Information System (INIS)

Gladden, J.B.; Lower, M.W.; Mackey, H.E.; Specht, W.L.; Wilde, E.W.

1985-07-01

This volume summarizes the technical content of Volumes II through XI of the annual report. Volume II provides a description of the SRP environment, facilities, and operation, and presents the objectives and design for the CCWS. Volume III presents information on water quality of SRP surface waters. Results of radionuclide and heavy metal transport studies are presented in Volume IV. Volume V contains findings from studies of wetland plant communities. Volume VI presents findings from studies of the lower food chain components of SRP aquatic habitats. The results of fisheries studies are reported in Volume VII. Studies of semi-aquatic vertebrate populations are reported in Volume VIII. Water-fowl utilization of SRP habitats is discussed in Volume IX. The status of endangered species that utilize SRP aquatic habitats is presented in Volume X. The findings from studies of Parr Pond ecosystem are presented in Volume XI

One-electron spectrum of Xe VIII

International Nuclear Information System (INIS)

Roberts, J.R.; Knystautas, E.J.; Sugar, J.

1979-01-01

The spectrum of Xe VIII has been observed in a theta-pinch discharge. New line identifications were made that determine the energies of the 6s, 7s, 6p, and 5f terms relative to the 5s 2 S ground state and confirm the previously known 5p and 5d terms. An independent system of levels derived from the observed 4f-ng (n = 5,6) transitions was found. Its position relative to the ground state is obtained from a predicted value for the 5g effective quantum number n*. From the ns series (n=5--7) a value for the ionization enegy of 105.91 +- 0.05 eV was derived

An ancillary method in urine cytology: Nucleolar/nuclear volume ratio for discrimination between benign and malignant urothelial cells.

Science.gov (United States)

Tone, Kiyoshi; Kojima, Keiko; Hoshiai, Keita; Kumagai, Naoya; Kijima, Hiroshi; Kurose, Akira

2016-06-01

The essential of urine cytology for the diagnosis and the follow-up of urothelial neoplasia has been widely recognized. However, there are some cases in which a definitive diagnosis cannot be made due to difficulty in discriminating between benign and malignant. This study evaluated the practicality of nucleolar/nuclear volume ratio (%) for the discrimination. Using Papanicolaou-stained slides, 253 benign urothelial cells and 282 malignant urothelial cells were selected and divided into a benign urothelial cell and an urothelial carcinoma (UC) cell groups. Three suspicious cases and four cases in which discrimination between benign and malignant was difficult were prepared for verification test. Subject cells were decolorized and stained with 4',6-diamidino-2-phenylindole for detection of the nuclei and the nucleoli. Z-stack method was performed to analyze. When the cutoff point of 1.514% discriminating benign urothelial cells and UC cells from nucleolar/nuclear volume ratio (%) was utilized, the sensitivity was 56.0%, the specificity was 88.5%, the positive predictive value was 84.5%, and the negative predictive value was 64.4%. Nuclear and nucleolar volume, number of the nucleoli, and nucleolar/nuclear volume ratio (%) were significantly higher in the UC cell group than in the benign urothelial cell group (P benign and malignant urothelial cells, providing possible additional information in urine cytology. Diagn. Cytopathol. 2016;44:483-491. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

University centres of nuclear competence as TSO's in small non-nuclear countries

International Nuclear Information System (INIS)

Jovanovic, Slobodan

2010-01-01

Montenegro is small, developing 'non-nuclear' country, the use of radiation sources being modest and limited to ordinary medical and industrial applications. Even though - and taking into account current and near-future status of the field - there is (or will be) significant need in nuclear knowledge. It goes about the following areas: (i) medical applications (diagnostics, radiotherapy, palliation, sterilization of equipment, consumables, blood products, etc.), (ii) environmental protection (radioecology, low and medium activity radioactive waste management, analytical and monitoring services, etc.), (iii) industrial, geological, hydrological, agricultural, biochemical and archaeological applications (non-destructive testing, various gauges, radioisotope labeling, etc.), (iv) scientific and educational applications, (v) radiation protection, emphasizing safety and security of radiation sources, (vi) legislative and regulatory aspects, including complying to international safety/ security norms and joining international conventions in the field, (vii) preparedness and response to radiological and nuclear emergency situations, (viii) combating illicit trafficking of nuclear and radioactive materials, (ix) forensic applications, (x) security systems based on X-ray and other nuclear methods, (xi) introduction of some future topics (e.g. nuclear power for electricity generation and sea water desalination) and (xii) information and communication with media. At present, there is clear a shortage in NK in the country, resulting i.a. from long lasting poor interest of young students for the subject University of Montenegro - the only state university in the country - effectuates practically complete high education in natural and technical sciences. At the Faculty of Natural Sciences and Mathematics, Department of Physics, there is a basic education in nuclear physics, while some post-graduate curricula offer topics in radioecology, medical physics and radiation protection

Second interim assessment of the Canadian concept for nuclear fuel waste disposal. Volume 3

International Nuclear Information System (INIS)

Johansen, K.; Donnelly, K.J.; Gee, J.H.; Green, B.J.; Nathwani, J.S.; Quinn, A.M.; Rogers, B.G.; Stevenson, M.A.; Dunford, W.E.; Tamm, J.A.

1985-12-01

The nuclear fuel waste disposal concept chosen for development and assessment in Canada involves the isolation of corrosion-resistant containers of waste in a vault located deep in plutonic rock. As the concept and the assessment tools are developed, periodic assessments are performed to permit evaluation of the methodology and provide feedback to those developing the concept. The ultimate goal of these assessments is to predict what impact the disposal system would have on man and the environment if the concept were implemented. The second such assessment was completed in 1984 and is documented in the Second Interim Assessment of the Canadian Concept for Nuclear Fuel Waste Disposal - Volumes 1-4. This, the third volume of the report, summarizes the pre-closure environmental and safety assessments completed by Ontario Hydro for Atomic Energy of Canada Limited. The preliminary results and their sigificance are discussed. 85 refs

Second interim assessment of the Canadian concept for nuclear fuel waste disposal. Volume 4

International Nuclear Information System (INIS)

Wuschke, D.M.; Gillespie, P.A.; Mehta, K.K.; Henrich, W.F.; LeNeveu, D.M.; Guvanasen, V.M.; Sherman, G.R.; Donahue, D.C.; Goodwin, B.W.; Andres, T.H.

1985-12-01

The nuclear fuel waste disposal concept chosen for development and assessment in Canada involves the isolation of corrosion-resistant containers of waste in a vault located deep in plutonic rock. As the concept and the assessment tools are developed, periodic assessments are performed to permit evaluation of the methodology and provide feedback to those developing the concept. The ultimate goal of these assessments is to predict what impact the disposal system would have on man and the environment if the concept were implemented. The second such assessment was performed in 1984 and is documented in the Second Interim Assessment of the Canadian Concept for Nuclear Fuel Waste Disposal - Volumes 1-4. This volume, entitled Post-Closure Assessment, describes the methods, models and data used to perform the second post-closure assessment. The results are presented and their significance is discussed. Conclusions and planned improvements are listed. 72 refs

Geoscience data base handbook for modeling a nuclear waste repository. Volume 1

International Nuclear Information System (INIS)

Isherwood, D.

1979-12-01

This handbook contains reference information on parameters that should be considered in analyzing or modeling a proposed nuclear waste repository site. Only those parameters and values that best represent the natural environment are included. Rare extremes are avoided. Where laboratory and field data are inadequate, theoretical treatments and informed engineering judgements are presented. Volume 1 contains a data base on salt as a repository medium. Chapters on the geology of bedded and dome salt, the geomechanics of salt, hydrology, geochemistry, natural and man-made features, and seismology provide compiled data and related information useful for studying a proposed repository in salt. These and other data will be needed to derive generic deep geologic modeling parameters and will also serve as background for the verification of source data that may be presented in licensing applications for nuclear waste repositories. Volume 2 is the result of a scoping study for a data base on the geology, geomechanics, and hydrology of shale, granite, and basalt as alternative repository media. Except for the geomechanics of shale, most of the sections contain relatively complete compilations of the available data, as well as discussions of the properties that are unique to each rock type

Cacotheline as an oxidimetric reagent. Determination of Sn(II), Cu(I), Ti(III), Fe(II), V(II) and V(III)

International Nuclear Information System (INIS)

Nemani Murty, K.; Yedluri Rao, P.; Geddada Chalam, K.

1982-01-01

Sn(II), Ti(III), Cu(I),Fe(II), V(III) and V(II) can be titrated potentiometrically with cacotheline in 1-4 M hydrochloric acid, 0.5-2 M hydrochloric acid, 0.5-1.5 M sulphuric acid in presence of 4 ml of 10% EDTA solution in a total volume of 50 ml, 9-10 M phosphoric acid, 4-8 M acetic acid and 3-8 M acetic acid respectively. Cacotheline can be used for the assay of tin plate and solder. The cacotheline undergoes a 2-electron reduction reaction. A cacotheline solution (0.005 M) in 0.02 M hydrochloric acid is fairly stable for several months. The conditional redox potentials of cacotheline have been determined in sulphuric, phosphoric and acetic acid medium. (Author)

46 CFR 54.01-2 - Adoption of division 1 of section VIII of the ASME Boiler and Pressure Vessel Code.

Science.gov (United States)

2010-10-01

... Boiler and Pressure Vessel Code. 54.01-2 Section 54.01-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND... division 1 of section VIII of the ASME Boiler and Pressure Vessel Code. (a) Pressure vessels shall be designed, constructed, and inspected in accordance with section VIII of the ASME Boiler and Pressure Vessel...

Influence of Problem Based Learning on Critical Thinking Skills and Competence Class VIII SMPN 1 Gunuang Omeh, 2016/2017

Science.gov (United States)

Aswan, D. M.; Lufri, L.; Sumarmin, R.

2018-04-01

This research intends to determine the effect of Problem Based Learning models on students' critical thinking skills and competences. This study was a quasi-experimental research. The population of the study was the students of class VIII SMPN 1 Subdistrict Gunuang Omeh. Random sample selection is done by randomizing the class. Sample class that was chosen VIII3 as an experimental class given that treatment study based on problems and class VIII1 as control class that treatment usually given study. Instrument that used to consist of critical thinking test, cognitive tests, observation sheet of affective and psychomotor. Independent t-test and Mann Whitney U test was used for the analysis. Results showed that there was significant difference (sig competences.

Occupational dose reduction at nuclear power plants: Annotated bibliography of selected readings in radiation protection and ALARA. Volume 7

Energy Technology Data Exchange (ETDEWEB)

Kaurin, D.G.; Khan, T.A.; Sullivan, S.G.; Baum, J.W. [Brookhaven National Lab., Upton, NY (United States)

1993-07-01

The ALARA Center at Brookhaven National Laboratory publishes a series of bibliographies of selected readings in radiation protection and ALARA in the continuing effort to collect and disseminate information on radiation dose reduction at nuclear power plants. This is volume 7 of the series. The abstracts in this bibliography were selected from proceedings of technical meetings and conferences, journals, research reports, and searches of the Energy Science and Technology database of the US Department of Energy. The subject material of these abstracts relates to radiation protection and dose reduction, and ranges from use of robotics to operational health physics, to water chemistry. Material on the design, planning, and management of nuclear power stations is included, as well as information on decommissioning and safe storage efforts. Volume 7 contains 293 abstract, an author index, and a subject index. The author index is specific for this volume. The subject index is cumulative and lists all abstract numbers from volumes 1 to 7. The numbers in boldface indicate the abstracts in this volume; the numbers not in boldface represent abstracts in previous volumes.

Occupational dose reduction at nuclear power plants: Annotated bibliography of selected readings in radiation protection and ALARA. Volume 8

Energy Technology Data Exchange (ETDEWEB)

Sullivan, S.G.; Khan, T.A.; Xie, J.W. [Brookhaven National Lab., Upton, NY (United States)

1995-05-01

The ALARA Center at Brookhaven National Laboratory publishes a series of bibliographies of selected readings in radiation protection and ALARA in a continuing effort to collect and disseminate information on radiation dose reduction at nuclear power plants. This volume 8 of the series. The abstracts in this bibliography were selected form proceedings of technical meetings and conference journals, research reports, and searches of the Energy Science and Technology database of the US Department of Energy. The subject material of these abstracts relates to the many aspects of radiation protection and dose reduction, and ranges form use of robotics, to operational health physics, to water chemistry. Material on the design, planning, and management of nuclear power stations is included, as well as information on decommissioning and safe storage efforts. Volume 8 contains 232 abstracts, an author index, and a subject index. The author index is specific for this volume. The subject index is cumulative and lists all abstract numbers from volumes 1 to 8. The numbers in boldface indicate the abstracts in this volume; the numbers not in boldface represent abstracts in previous volumes.

Occupational dose reduction at nuclear power plants: Annotated bibliography of selected readings in radiation protection and ALARA. Volume 8

International Nuclear Information System (INIS)

Sullivan, S.G.; Khan, T.A.; Xie, J.W.

1995-05-01

The ALARA Center at Brookhaven National Laboratory publishes a series of bibliographies of selected readings in radiation protection and ALARA in a continuing effort to collect and disseminate information on radiation dose reduction at nuclear power plants. This volume 8 of the series. The abstracts in this bibliography were selected form proceedings of technical meetings and conference journals, research reports, and searches of the Energy Science and Technology database of the US Department of Energy. The subject material of these abstracts relates to the many aspects of radiation protection and dose reduction, and ranges form use of robotics, to operational health physics, to water chemistry. Material on the design, planning, and management of nuclear power stations is included, as well as information on decommissioning and safe storage efforts. Volume 8 contains 232 abstracts, an author index, and a subject index. The author index is specific for this volume. The subject index is cumulative and lists all abstract numbers from volumes 1 to 8. The numbers in boldface indicate the abstracts in this volume; the numbers not in boldface represent abstracts in previous volumes

Safety, efficacy and pharmacokinetics of rVIII-SingleChain in children with severe hemophilia A: results of a multicenter clinical trial.

Science.gov (United States)

Stasyshyn, O; Djambas Khayat, C; Iosava, G; Ong, J; Abdul Karim, F; Fischer, K; Veldman, A; Blackman, N; St Ledger, K; Pabinger, I

2017-04-01

Essentials rVIII-SingleChain is a novel recombinant factor VIII with covalently bonded heavy and light chains. Efficacy, safety and pharmacokinetics were studied in pediatric patients with severe hemophilia A. Across all prophylaxis regimens, the median annualized spontaneous bleeding rate was 0.00. rVIII-SingleChain showed excellent hemostatic efficacy and a favorable safety profile. Background rVIII-SingleChain is a novel B-domain truncated recombinant factor VIII (rFVIII) comprised of covalently bonded FVIII heavy and light chains, demonstrating a high binding affinity to von Willebrand factor. Objectives This phase III study investigated the safety, efficacy and pharmacokinetics of rVIII-SingleChain in previously treated pediatric patients hemophilia A. Patients/Methods Patients could be assigned to prophylaxis or on-demand therapy by the investigator. For patients assigned to prophylaxis, the treatment regimen and dose were based on the bleeding phenotype. For patients receiving on-demand therapy, dosing was guided by World Federation of Hemophilia recommendations. The primary endpoint was treatment success, defined as a rating of 'excellent' or 'good' on the investigator's clinical assessment of hemostatic efficacy for all treated bleeding events. Results The study enrolled 84 patients (0 to 50 EDs. In the 347 bleeds treated and evaluated by the investigator, hemostatic efficacy was rated as excellent or good in 96.3%. The median annualized spontaneous bleeding rate was 0.00 (Q1, Q3: 0.00, 2.20), and the median annualized bleeding rate was 3.69 (Q1, Q3: 0.00, 7.20) across all prophylaxis regimens. No participant developed an inhibitor. Conclusions rVIII-SingleChain is a novel rFVIII molecule showing excellent hemostatic efficacy and a favorable safety profile in a clinical study in children hemophilia A. © 2017 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and

Data base on dose reduction research projects for nuclear power plants. Volume 4

Energy Technology Data Exchange (ETDEWEB)

Khan, T.A.; Vulin, D.S.; Liang, H.; Baum, J.W. [Brookhaven National Lab., Upton, NY (United States)

1992-08-01

This is the fourth volume in a series of reports that provide information on dose reduction research and health physics technology for nuclear power plants. The information is taken from a data base maintained by Brookhaven National Laboratory`s ALARA Center for the Nuclear Regulatory Commission. This report presents information on 118 new or updated projects, covering a wide range of activities. Projects including steam generator degradation, decontamination, robotics, improvement in reactor materials, and inspection techniques, among others, are described in the research section of the report. The section on health physics technology includes some simple and very cost-effective projects to reduce radiation exposures. Included in this volume is a detailed description of how to access the BNL data bases which store this information. All project abstracts from this report, as well as many other useful documents, can be accessed, with permission, through our on-line system, ACE. A computer equipped with a modem, or a fax machine is all that is required to connect to ACE. Many features of ACE, including software, hardware, and communications specifics, are explained in this report.

Chaos in long-term behavior of some Bianchi-type VIII models

Energy Technology Data Exchange (ETDEWEB)

Halpern, P

1987-01-01

The long-term behavior of Bianchi-type VIII models with three different types of stress-energy tensors are examined and compared. The vacuum model, a matter-filled model, and a model with an electromagnetic field are considered. In each case the existence of chaotic behavior and transitions to chaotic behavior are discussed.

Severe Hemophilia A in a Male Old English Sheep Dog with a C→T Transition that Created a Premature Stop Codon in Factor VIII

Science.gov (United States)

Lozier, Jay N; Kloos, Mark T; Merricks, Elizabeth P; Lemoine, Nathaly; Whitford, Margaret H; Raymer, Robin A; Bellinger, Dwight A; Nichols, Timothy C

2016-01-01

Animals with hemophilia are models for gene therapy, factor replacement, and inhibitor development in humans. We have actively sought dogs with severe hemophilia A that have novel factor VIII mutations unlike the previously described factor VIII intron 22 inversion. A male Old English Sheepdog with recurrent soft-tissue hemorrhage and hemarthrosis was diagnosed with severe hemophilia A (factor VIII activity less than 1% of normal). We purified genomic DNA from this dog and ruled out the common intron 22 inversion; we then sequenced all 26 exons. Comparing the results with the normal canine factor VIII sequence revealed a C→T transition in exon 12 of the factor VIII gene that created a premature stop codon at amino acid 577 in the A2 domain of the protein. In addition, 2 previously described polymorphisms that do not cause hemophilia were present at amino acids 909 and 1184. The hemophilia mutation creates a new TaqI site that facilitates rapid genotyping of affected offspring by PCR and restriction endonuclease analyses. This mutation is analogous to the previously described human factor VIII mutation at Arg583, which likewise is a CpG dinucleotide transition causing a premature stop codon in exon 12. Thus far, despite extensive treatment with factor VIII, this dog has not developed neutralizing antibodies (‘inhibitors’) to the protein. This novel mutation in a dog gives rise to severe hemophilia A analogous to a mutation seen in humans. This model will be useful for studies of the treatment of hemophilia. PMID:27780008

Synthesis of dispersive iron or iron–silver nanoparticles on engineered capsid pVIII of M13 virus with electronegative terminal peptides

Energy Technology Data Exchange (ETDEWEB)

Zhang, Shuai; Nakano, Kazuhiko; Zhang, Shu-liang; Yu, Hui-min, E-mail: yuhm@tsinghua.edu.cn [Tsinghua University, Key Laboratory of Industrial Biocatalysis of the Ministry of Education, Department of Chemical Engineering (China)

2015-10-15

M13 is a filamentous Escherichia coli virus covered with five types of capsid proteins, in which pVIII with ∼2700 copies was around the cylindered surface and pIII with five copies located at one end of the phage particle. The pIII-engineered M13 phages with enhanced binding specificity toward Fe were screened after five rounds of biopanning, and the one containing ATPTVAMSLSPL peptide at pIII-terminus was selected for mediated synthesis of zero valent (ZV) Fe nanoparticles (NPs) with the wild M13 as control. Under a reducing environment, uniformly dispersed ZVFeNPs with diameter of 5–10 nm were both synthesized and the morphologies after annealing were confirmed to be face-centered cubic type. The synthesized FeNPs mediated by the two phages showed no significant difference, revealing that the pVIII capsid did dominant contribution to metal binding in comparison with the pIII. A novel pVIII-engineered M13 containing AAEEEDPAK at terminus, named as 4ED-pVIII-M13, was constructed and it carried one more negatively charged residue than the wild one (AEGDDPAK). Metal adsorption quantification showed that the binding affinity of the 4ED-pVIII-M13 toward Ag and Ni ions improved to 62 and 18 % from original 21 and 6 %, respectively. The binding affinity toward Fe remained constant (∼85 %). ZVFe–Ag bi-NPs were successfully synthesized through mediation of 4ED-pVIII-M13. Particularly, the Fe:Ag ratio in the bi-NPs was conveniently controlled through changing the molar concentration of FeCl{sub 2} and AgNO{sub 3} solution before reduction.

Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells

NARCIS (Netherlands)

van den Biggelaar, M.; Bouwens, E.A.M.; Kootstra, N.A.; Hebbel, R.P.; Voorberg, J.; Mertens, K.

2009-01-01

Background Gene therapy provides an attractive alternative for protein replacement therapy in hemophilia A patients. Recent studies have shown the potential benefit of directing factor (F)VIII gene delivery to cells that also express its natural carrier protein von Willebrand factor (VWF). In this

Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells

NARCIS (Netherlands)

van den Biggelaar, Maartje; Bouwens, Eveline A. M.; Kootstra, Neeltje A.; Hebbel, Robert P.; Voorberg, Jan; Mertens, Koen

2009-01-01

Gene therapy provides an attractive alternative for protein replacement therapy in hemophilia A patients. Recent studies have shown the potential benefit of directing factor (F)VIII gene delivery to cells that also express its natural carrier protein von Willebrand factor (VWF). In this study, we

Department of Energy Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs draft environmental impact statement. Volume 1, Appendix B: Idaho National Engineering Laboratory Spent Nuclear Fuel Management Program

Energy Technology Data Exchange (ETDEWEB)

1994-06-01

The US Department of Energy (DOE) has prepared this report to assist its management in making two decisions. The first decision, which is programmatic, is to determine the management program for DOE spent nuclear fuel. The second decision is on the future direction of environmental restoration, waste management, and spent nuclear fuel management activities at the Idaho National Engineering Laboratory. Volume 1 of the EIS, which supports the programmatic decision, considers the effects of spent nuclear fuel management on the quality of the human and natural environment for planning years 1995 through 2035. DOE has derived the information and analysis results in Volume 1 from several site-specific appendixes. Volume 2 of the EIS, which supports the INEL-specific decision, describes environmental impacts for various environmental restoration, waste management, and spent nuclear fuel management alternatives for planning years 1995 through 2005. This Appendix B to Volume 1 considers the impacts on the INEL environment of the implementation of various DOE-wide spent nuclear fuel management alternatives. The Naval Nuclear Propulsion Program, which is a joint Navy/DOE program, is responsible for spent naval nuclear fuel examination at the INEL. For this appendix, naval fuel that has been examined at the Naval Reactors Facility and turned over to DOE for storage is termed naval-type fuel. This appendix evaluates the management of DOE spent nuclear fuel including naval-type fuel.

Department of Energy Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs Draft Environmental Impact Statement. Volume 1, Appendix C, Savannah River Site Spent Nuclear Fuel Mangement Program

Energy Technology Data Exchange (ETDEWEB)

1994-06-01

The US Department of Energy (DOE) is engaged in two related decision making processes concerning: (1) the transportation, receipt, processing, and storage of spent nuclear fuel (SNF) at the DOE Idaho National Engineering Laboratory (INEL) which will focus on the next 10 years; and (2) programmatic decisions on future spent nuclear fuel management which will emphasize the next 40 years. DOE is analyzing the environmental consequences of these spent nuclear fuel management actions in this two-volume Environmental Impact Statement (EIS). Volume 1 supports broad programmatic decisions that will have applicability across the DOE complex and describes in detail the purpose and need for this DOE action. Volume 2 is specific to actions at the INEL. This document, which limits its discussion to the Savannah River Site (SRS) spent nuclear fuel management program, supports Volume 1 of the EIS. Following the introduction, Chapter 2 contains background information related to the SRS and the framework of environmental regulations pertinent to spent nuclear fuel management. Chapter 3 identifies spent nuclear fuel management alternatives that DOE could implement at the SRS, and summarizes their potential environmental consequences. Chapter 4 describes the existing environmental resources of the SRS that spent nuclear fuel activities could affect. Chapter 5 analyzes in detail the environmental consequences of each spent nuclear fuel management alternative and describes cumulative impacts. The chapter also contains information on unavoidable adverse impacts, commitment of resources, short-term use of the environment and mitigation measures.

Safety Research Experiment Facility Project. Conceptual design report. Volume VIII. Instrumentation and control

International Nuclear Information System (INIS)

1975-01-01

Included are sections dealing with the following: nuclear instrumentation system, reactor control system, plant protection system, plant annunciator system, data acquisition system, and reactor cooling system instrumentation and control

The Effect of Growth Temperature and V/III Flux Ratio of MOCVD Antimony Based Semiconductors on Growth Rate and Surface Morphology

Directory of Open Access Journals (Sweden)

Ramelan Ari Handono

2017-01-01

Full Text Available Epitaxial Alx Ga1-x Sb layers on GaSb and GaAs substrates have been grown by atmospheric pressure metalorganic chemical vapor deposition using TMAl, TMGa and TMSb. Nomarski microscope and a profiler were employed to examine the surface morphology and growth rate of the samples. We report the effect of growth temperature and V/III flux ratio on growth rate and surface morphology. Growth temperatures in the range of 520°C and 680°C and V/III ratios from 1 to 5 have been investigated. A growth rate activation energy of 0.73 eV was found. At low growth temperatures between 520 and 540°C, the surface morphology is poor due to antimonide precipitates associated with incomplete decomposition of the TMSb. For layers grown on GaAs at 580°C and 600°C with a V/III ratio of 3 a high quality surface morphology is typical, with a mirror-like surface and good composition control. It was found that a suitable growth temperature and V/III flux ratio was beneficial for producing good AlGaSb layers. Undoped AlGaSb grown at 580°C with a V/III flux ratio of 3 at the rate of 3.5 μm/hour shows p-type conductivity with smooth surface morphology

Incineration as a radioactive waste volume reduction process for CEA nuclear centers

International Nuclear Information System (INIS)

Atabek, R.; Chaudon, L.

1994-01-01

Incineration processes represent a promising solution for waste volume reduction, and will be increasingly used in the future. The features and performance specifications of low-level waste incinerators with capacities ranging from 10 to 20 kg - h -1 at the Fontenay-aux-Roses, Grenoble and Cadarache nuclear centers in France are briefly reviewed. More extensive knowledge of low-level wastes produced in facilities operated by the Commissariat a l'Energie Atomique (CEA) has allowed us to assess the volume reduction obtained by processing combustible waste in existing incinerators. Research and development work is in progress to improve management procedures for higher-level waste and to build facilities capable of incinerating α - contaminated waste. (authors). 6 refs., 5 figs., 1 tab

Absorption signatures of warm-hot gas at low redshift : Ne VIII

NARCIS (Netherlands)

Tepper-García, T

2013-01-01

At z {lt} 1 a large fraction of the baryons is thought to reside in diffuse gas that has been shock-heated to high temperatures (10$^{5}$-10$^{6}$ K). Absorption by the 770.41, 780.32 å doublet of Ne VIII in quasar spectra represents a unique tool to study this elusive warm-hot phase. We have

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.4--isotope separation sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 37 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the fourth one, the content is about isotope separation sub-volume

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.6--computational physics sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 13 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the sixth one, the content is about computational physics sub-volume

Factor VIII S373L: mutation at P1' site confers thrombin cleavage resistance, causing mild haemophilia A.

Science.gov (United States)

Johnson, D J; Pemberton, S; Acquila, M; Mori, P G; Tuddenham, E G; O'Brien, D P

1994-04-01

A novel CRM+ mutation, factor VIII position 373 serine to leucine substitution (FVIII 373-Leu) was identified during a survey of Factor VIII (FVIII) mutations. We have purified the variant protein from the patient's plasma in order to allow further characterisation of the molecule. The CRM+ plasma contained 120% Factor VIII antigen (FVIII:Ag) and 6% Factor VIII coagulant activity (FVIII:C). After purification the mutant FVIII was subjected to thrombin proteolysis, and was thereby activated 5.6-fold compared with 7-fold for wild type molecule. Subsequently, spontaneous inactivation of the mutant was much slower than noted for wild type FVIII. Western blot analysis using monoclonal antibodies demonstrated that thrombin cleavage of FVIII 373-Leu at positions 740 and 1689 were normal but that cleavage at position 372 was completely absent. Crystallographic coordinates of the active site of thrombin complexed to fibrinopeptide A were used to explore possible mechanistic reasons for the failure of thrombin to cleave the mutant FVIII at position 372. Steric hindrance between the mutant side chain and the side chain of the P1 residue was apparent. We conclude that the functional defect of FVIII 373-Leu results from the inability of thrombin to cleave the mutant at position 372-373, and propose that this is due to steric hindrance by the side chain of leucine 373, preventing correct formation of the enzyme substrate complex.

The new albumin-free recombinant factor VIII concentrates for treatment of hemophilia: do they represent an actual incremental improvement?

Science.gov (United States)

Josephson, Cassandra D; Abshire, Thomas

2004-07-01

The goal of eliminating the low levels of infectious disease risk from hemophilia treatment has resulted in the development of multiple generations of recombinant factor VIII (rFVIII) products. The ideal product should be devoid of human and animal proteins, which may transmit infectious agents. These products should also maintain molecular integrity, hemostatic efficacy, similar immunogenicity, and acceptable side effect profiles as compared to plasma-derived factor VIII. Currently available first-, second-, and third-generation rFVIII products include Recombinate; Kogenate FS/Helixate FS and ReFacto; and Advate, respectively. During the evolution of rFVIII products, either full-length or B-domain-deleted factor VIII were transfected into immortalized cell lines. The B-domain-deleted product, ReFacto, has resulted in an additional method to monitor factor VIII levels. The third-generation products offer the theoretical advantage of being produced without human and/or animal proteins. Upon initial introduction into the marketplace, the newer products have a higher cost. However, when analyzing historical trends, the prices of these products are almost equivalent to first-generation products within 3 years of licensure. Thus, the initial cost of the product may be a minimal issue in the medical decision process when selecting rFVIII replacement therapy.

Quark matter coupled to domain walls in Bianchi types II, VIII and IX ...

Indian Academy of Sciences (India)

In this study of Bianchi types II, VIII and IX Universes, quark matter coupled to domain walls in the ... The self-bound state appears to be at ρ ... The observations suggest that the Hubble expansion of the Universe ... Taking motivation from.

PENGARUH KEMANDIRIAN BELAJAR DAN PENGGUNAAN UANG SAKU TERHADAP PRESTASI BELAJAR KOMPETENSI DASAR EKONOMI KELAS VII DAN VIII

Directory of Open Access Journals (Sweden)

Apri Dwi Astuti

2012-10-01

Full Text Available Kemandirian belajar membantu siswa untuk bertanggung jawab dan menumbuhkan kesadaran belajar. Penggunaan uang saku menumbuhkan jiwa mandiri, jujur dan komitmen. Adapun hasil observasi awal menunjukkan masih ada siswa kels VII dan VIII SMP Semesta untuk kompetensi dasar ekonomi dibawah KKM. Tujuan penelitian ini untuk mengetahui pengaruh kemandirian belajar dn penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta. Populasi penelitian ini adalah semua siswa kelas VII dan VIII SMP Semesta Boarding School Semarang. Variabel penelitian ini adalah kemandirian belajar dan penggunaan uang saku sebagai variabel bebas, sedangkan untuk� variabel terikat adalah prestasi belajar kompetensi dasar ekonomi. Data diambil dengan metode wawancara, kuesioner dan dokumentasi guru. Analisis data menggunakan analisis regresi linear berganda.Berdasarkan penelitian secara simultan menunjukkan adanya pengaruh antara kemandirian belajar dan penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi sebesar 51,3%. Secara parsial, pengaruh kemandirian belajar terhadap prestasi belajar kompetensi dasar ekonomi sebesar 66,2% dan pengaruh penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi sebesar 62,5%.Berdasarkan hasil penelitian diatas disimpulkan bahwa kemandirian belajar dan penggunaan uang saku berpengaruh positif baik secara simultan maupun parsial terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta Boarding school semarang tahun pelajaran 2011/2012. Saran yang berkaitan dengan penelitian ini yaitu : 1 Sekolah disarankan untuk memberikan batasan siswa pulang ke rumah agar dapat membantu siswa beradaptasi dengan cepat dan mudah tinggal di asrama. 2 Orang tua disarankan untuk memberikan uang saku yang disesuaikan dengan kebutuhan siswa. 3 Siswa disarankan untuk meningkatkan kemandirian dalam aspek belajar terutama bagi mata pelajaran yang masih kurang dari

Leonor Plantagenet y la consolidación castellana en el reinado de Alfonso VIII

Directory of Open Access Journals (Sweden)

Cerda, José Manuel

2012-12-01

Full Text Available The kingdom of Castile experienced a process of political and territorial consolidation between the death of Sancho III in 1158 and the Curia of Carrión de los Condes in 1188, leaving behind the troublesome minority of Alfonso VIII and the subordination to the kingdom of Leon, and thus becoming a dominant power within the peninsula, and one that achieved considerable success in the Reconquest. The following article is part of a biographical approach to Eleanor Plantagenet, queen consort of Alfonso VIII, and by means of a specifi c focus offers an analysis of the role played by the English queen in this process of political consolidation of Castile. As we approach the eighth centenary of her death, the life and work of this little-studied woman emerges as a testimony to the important diplomatic and cultural tasks assumed by queens in twelfth-century Europe.

Desde la muerte de Sancho III en 1158 a la Curia de Carrión de los Condes en 1188, el reino castellano experimentó una consolidación política y territorial que dejó atrás la problemática minoría de Alfonso VIII y la subordinación al reino de León, que lo constituyó en un poder dominante dentro de la península y que logró un avance importante en la empresa reconquistadora. El presente trabajo es parte de un acercamiento biográfico a Leonor Plantagenet, consorte de Alfonso VIII, y que por medio de un enfoque particular ofrece un análisis de la incidencia que tuvo la reina inglesa en este proceso de afianzamiento político de Castilla. En las vísperas del octavo centenario de su muerte, la vida y obra de esta mujer hasta ahora poco estudiada, surge como un testimonio importante a la labor diplomática y cultural que asumían las reinas en la Europa del siglo XII.

VIII Brazilian Meeting on Simulational Physics (BMSP)

International Nuclear Information System (INIS)

Branco, N. S.; Figueiredo, W.; Plascak, J. A.; Santos, M.

2016-01-01

This special issue includes invited and selected articles of the VIII Brazilian Meeting on Simulational Physics (BMSP), held in Florianópolis, Santa Catarina, Brazil, from 3rd to 8th August, 2015. This is the eighth such meeting, and the second one to have contributed papers published in Journal of Physics: Conference Series (the other was the VII BMSP). The previous meetings in the BMSP series took place in the mountains of Minas Gerais, in the region of the Brazilian Pantanal, and in the shores of Paraíba. Now, for the first time, the Meeting was held in Florianópolis, with its pleasing shores, the capital of Santa Catarina state. The VIII BMSP brought together about 50 researchers from all over the world for a vibrant and productive conference. As in the previous meetings, the talks and posters highlighted recent advances in applications, algorithms, and implementation of computer simulation methods for the study of condensed matter, materials, and out of equilibrium, quantum and biologically motivated systems. We are sure that this meeting series will continue to be an important occasion for people working in simulational physics to exchange ideas and discuss the state of the art of this always expanding field. We are very glad to put together this special issue, and are most appreciative of the efforts of the editors of the Journal of Physics: Conference Series for making this publication possible. We are grateful for the outstanding work of the Florianopolis team, for the financial support of the Brazilian agencies CAPES and CNPq, and of the Federal Universities UFPB and UFSC. At last, but not least, we would like to acknowledge all of the authors for their written submissions. (paper)

Data base on dose reduction research projects for nuclear power plants. Volume 5

Energy Technology Data Exchange (ETDEWEB)

Khan, T.A.; Yu, C.K.; Roecklein, A.K. [Brookhaven National Lab., Upton, NY (United States)

1994-05-01

This is the fifth volume in a series of reports that provide information on dose reduction research and health physics technology or nuclear power plants. The information is taken from two of several databases maintained by Brookhaven National Laboratory`s ALARA Center for the Nuclear Regulatory Commission. The research section of the report covers dose reduction projects that are in the experimental or developmental phase. It includes topics such as steam generator degradation, decontamination, robotics, improvements in reactor materials, and inspection techniques. The section on health physics technology discusses dose reduction efforts that are in place or in the process of being implemented at nuclear power plants. A total of 105 new or updated projects are described. All project abstracts from this report are available to nuclear industry professionals with access to a fax machine through the ACEFAX system or a computer with a modem and the proper communications software through the ACE system. Detailed descriptions of how to access all the databases electronically are in the appendices of the report.

Methods for volume reduction and recycling of LLW arising from decommissioning of nuclear installations

International Nuclear Information System (INIS)

Krause, G.; Bergstroem, L.

2003-01-01

Radioactive contaminated waste is a great cost factor for nuclear power plants and other nuclear industry. On the deregulated electricity market the price of produced kWh is an important competition tool. Therefore many power producers in the process to achieve savings and hence low production costs have given waste minimization and volume reduction highest priority. Studsvik RadWaste AB in Nykoeping, Sweden, is successfully providing incineration and scrap metal treatment services for customers from Europe, Japan and the USA. Since 1987 thousands of tonnes of metal have been released for unrestricted re-use and recycling in commercial steel industry. The incineration service, provided since 1976, results in 97% volume reduction and generates biologically inert ash suitable for disposal in a final radioactive waste repository. Both processes, which are quality and environmentally certified, reduce the cost of interim storage and disposal. In addition, the companies within the Studsvik Group offer a wide range of services such as transportation, measurement and safeguard, site assistance, industrial cleaning and decontamination in connection with demolition on site. (authors)

International Nuclear Model. Volume 3. Program description. Appendix A-H (Part 1)

International Nuclear Information System (INIS)

Andress, D.

1985-01-01

The International Nuclear Model (INM) is a comprehensive model of the commercial nuclear power industry. It simulates economic decisions for reactor deployment and fuel management decisions based on an input set of technical, economic and scenario parameters. The technical parameters include reactor operating characteristics, fuel cycle timing and mass loss factors, and enrichment tails assays. Economic parameters include fuel cycle costs, financial data, and tax alternatives. INM has a broad range of scenario options covering, for example, process constraints, interregional activities, reprocessing, and fuel management selection. INM reports reactor deployment schedules, electricity generation, and fuel cycle requirements and costs. It also has specialized reports for extended burnup and permanent disposal. This volume contains appendices A through H including a description of subroutines and the Fortran listing of the program

Complexation of the cesium cation with lithium ionophore VIII: extraction and DFT study

Czech Academy of Sciences Publication Activity Database

Makrlík, E.; Novák, Vít; Vaňura, P.; Bouř, Petr

2013-01-01

Roč. 298, č. 3 (2013), s. 2065-2068 ISSN 0236-5731 Institutional support: RVO:61388963 Keywords : cesium cation * lithium ionophore VIII * complexation * extraction and stability constants * water-nitrobenzene system * DFT calculations * structures Subject RIV: CB - Analytical Chemistry , Separation Impact factor: 1.415, year: 2013

Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume IV. Commercial potential

International Nuclear Information System (INIS)

1979-12-01

Volume IV provides time and cost estimates for positioning new nuclear power systems for commercial deployment. The assessment also estimates the rates at which the new systems might penetrate the domestic market, assuming the continuing viability of the massive light-water reactor network that now exists worldwide. This assessment does not recommend specific, detailed program plans and budgets for individual systems; however, it is clear from this analysis that any of the systems investigated could be deployed if dictated by national interest

The 1.7 Å X-ray crystal structure of the porcine factor VIII C2 domain and binding analysis to anti-human C2 domain antibodies and phospholipid surfaces.

Directory of Open Access Journals (Sweden)

Caileen M Brison

Full Text Available The factor VIII C2 domain is essential for binding to activated platelet surfaces as well as the cofactor activity of factor VIII in blood coagulation. Inhibitory antibodies against the C2 domain commonly develop following factor VIII replacement therapy for hemophilia A patients, or they may spontaneously arise in cases of acquired hemophilia. Porcine factor VIII is an effective therapeutic for hemophilia patients with inhibitor due to its low cross-reactivity; however, the molecular basis for this behavior is poorly understood. In this study, the X-ray crystal structure of the porcine factor VIII C2 domain was determined, and superposition of the human and porcine C2 domains demonstrates that most surface-exposed differences cluster on the face harboring the "non-classical" antibody epitopes. Furthermore, antibody-binding results illustrate that the "classical" 3E6 antibody can bind both the human and porcine C2 domains, although the inhibitory titer to human factor VIII is 41 Bethesda Units (BU/mg IgG versus 0.8 BU/mg IgG to porcine factor VIII, while the non-classical G99 antibody does not bind to the porcine C2 domain nor inhibit porcine factor VIII activity. Further structural analysis of differences between the electrostatic surface potentials suggest that the C2 domain binds to the negatively charged phospholipid surfaces of activated platelets primarily through the 3E6 epitope region. In contrast, the G99 face, which contains residue 2227, should be distal to the membrane surface. Phospholipid binding assays indicate that both porcine and human factor VIII C2 domains bind with comparable affinities, and the human K2227A and K2227E mutants bind to phospholipid surfaces with similar affinities as well. Lastly, the G99 IgG bound to PS-immobilized factor VIII C2 domain with an apparent dissociation constant of 15.5 nM, whereas 3E6 antibody binding to PS-bound C2 domain was not observed.

KEANEKARAGAMAN HYMENOPTERA PARASITOID PADA PERKEBUNAN KELAPA SAWIT PTPN VIII CINDALI, BOGOR

Directory of Open Access Journals (Sweden)

Ichsan Luqmana Indra Putra

2016-09-01

Full Text Available Diversity of parasitic Hymenoptera in PTPN VIII oil palm plantation Cindali, Bogor. One group of important natural enemies in oil palm plantation is parasitic Hymenoptera. The purpose of this research is to know the diversity and fluctuation of parasitic Hymenoptera PTPN VIII Cindali oil palm plantation. This research was conducted in 6 blocks of oil palm in September 2014 – June 2015. There were 5 plots in every observation blocks 39.2 x 39.2 m in size, and used direct and indirect method. Direct method done by 5 plants in every plots was taken randomized to observed and taken the herbivore insects to reared until the parasitic Hymenoptera came out. Observation of cover crops conducted by 3 subplots determined diagonally in every plots 9.8 x 9.8 m in size and herbivore insects was observed and collected. Indirect methods used sweep net and yellow pan trap. The result of this research, 26 parasitic Hymenoptera families was found, with the Braconidae was the most morphospecies found and the most individual amount was Scelionidae. The abundance of parasitoid in every month fluctuated.

Estimates of nuclear volume in plaque and tumor-stage mycosis fungoides. A new prognostic indicator

DEFF Research Database (Denmark)

Brooks, B; Sørensen, Flemming Brandt; Thestrup-Pedersen, K

1994-01-01

It is well documented that mycosis fungoides (MF), a cutaneous T-cell lymphoma, has a variable clinical course. Unbiased stereological estimates of three-dimensional volume-weighted mean nuclear size (nucl vV) of mycosis cells were obtained in a retrospective study of 18 patients with a total of ...

Nuclear power. Volume 2: nuclear power project management

International Nuclear Information System (INIS)

Anon.

1980-01-01

The following topics are discussed: review of nuclear power plants; licensing procedures; safety analysis; project professional services; quality assurance and project organization; construction, scheduling and operation; construction, scheduling and operation; nuclear fuel handling and fuel management; and plant cost management. 116 references, 115 figures, 33 tables

Expressão citofotométrica dos marcadores tumorais CD-34 e fator VIII no câncer de cólon

Directory of Open Access Journals (Sweden)

Cacilda Joyce Ferreira da Silva Garcia

Full Text Available OBJETIVOS: Verificar a posssibilidade de quantificar a expressão dos marcadores tumorais CD-34 e Fator VIII no câncer de cólon; verificar se existe superioridade entre um marcador e outro para estudo da angiogênese; verificar se há correlação na análise do índice de marcagem e a densidade óptica média nos marcadores utilizados. MÉTODOS: Dezessete casos de adenocarcinoma colorretal recuperados de blocos de parafina e confirmados pela hematoxilina-eosina, foram submetidos à coloração imunoistoquímica pelo método da estreptoavidina-biotina-peroxidase e utilizados os marcadores tumorais CD-34 e Fator VIII. Após este processo as lâminas foram submetidas à leitura no sistema Samba 4000® e avaliadas pelo software Immuno®. Os parâmetros estudados foram: índice de marcagem e densidade óptica, expressos por médias, medianas, valores mínimos, valores máximos e desvios-padrão, analisados estatisticamente. RESULTADOS: Para o marcador CD-34 não houve normalidade dos dados em relação ao índice de marcagem e houve para a densidade óptica. Para o Fator VIII, houve normalidade de dados em relação ao índice de marcagem e para a densidade óptica. CONCLUSÃO: Foi possível quantificar a expressão dos marcadores tumorais CD-34 e Fator VIII através do índice de marcagem e da densidade óptica média; não houve diferença entre os marcadores em relação à média do índice de marcagem e da densidade óptica, não sendo possível definir superioridade entre um e outro; não foi observada tendência à correlação quando comparados densidade óptica e índice de marcagem do Fator VIII e do CD-34 isoladamente estudados; não houve correlação entre o índice de marcagem do Fator VIII quando comparado com o CD-34, bem como a densidade óptica do Fator VIII com o CD-34.

Quark matter coupled to domain walls in Bianchi types II, VIII and IX ...

Indian Academy of Sciences (India)

In this study of Bianchi types II, VIII and IX Universes, quark matter coupled to domain walls in the context of general relativity are explored. To obtain deterministic solution of the Einstein's field equations, various techniques are adopted. The features of the obtained solution are discussed.

Safety and Efficacy of BAY 94-9027, a Prolonged-Half-Life Factor VIII

DEFF Research Database (Denmark)

Reding, M T; Ng, H J; Poulsen, Lone Hvitfeldt

2017-01-01

BACKGROUND: BAY 94-9027 is a B-domain-deleted prolonged-half-life recombinant factor VIII (FVIII) conjugates in a site-specific manner with polyethylene glycol. OBJECTIVE: Assess efficacy and safety of BAY 94-9027 for prophylaxis and treatment of bleeds in patients with severe hemophilia A PATIEN...

Data base on dose reduction research projects for nuclear power plants: Volume 3

Energy Technology Data Exchange (ETDEWEB)

Khan, T.A.; Baum, J.W.

1989-05-01

This is the third volume in a series of reports that provide information on dose-reduction research and health physics technology for nuclear power plants. The information is taken from data base maintained by Brookhaven National Laboratory's ALARA Center for the Nuclear Regulatory Commission. This report presents information on 80 new projects, covering a wide area of activities. Projects on steam generator degradation, decontamination, robotics, improvement in reactor materials, and inspection techniques, among others, are described in the research section. The section on health physics technology includes some simple and very cost-effective projects to reduce radiation exposures. Collective dose data from the United States and other countries are also presented. In the conclusion, we suggest that although new advanced reactor design technology will eventually reduce radiation exposures at nuclear power plants to levels below serious concern, in the interim an aggressive approach to dose reduction remains necessary. 20 refs.

Keefektifan Experiential Learning Berbantuan Origami Terhadap Kemampuan Keruangan Siswa Kelas VIII

Directory of Open Access Journals (Sweden)

Isnaeni Umi Machromah

2014-11-01

Full Text Available AbstrakPenelitian eksperimen ini bertujuan untuk mengetahui keefektifan pembelajaran Experiential Learning berbantuan origami terhadap kemampuan keruangan siswa dengan kualifikasi keefektifan yang telah ditentukan. Populasi yaitu siswa kelas VIII SMP Negeri 3 Colomadu tahun pelajaran 2012/2013. Sampel diambil secara simple random sampling. Hasil penelitian ini yaitu: (1 Uji proporsi ketuntasan belajar menunjukkan siswa kelompok eksperimen telah mencapai ketuntasan belajar; (2 Uji perbedaan dua rata-rata menghasilkan simpulan bahwa rata-rata hasil post-test kemam-puan keruangan siswa kelompok eksperimen lebih dari kelompok kontrol; (3 Analisis re-gresi menunjukkan bahwa motivasi belajar siswa memberikan pengaruh positif sebesar 49,3% terhadap kemampuan keruangan siswa; (4 Uji gain ternormalisasi menunjukkan terdapat peningkatan kemampuan keruangan siswa secara signifikan pada kategaori sedang untuk kelompok eksperimen dan kategori rendah untuk kelompok kontrol. Simpulan yang diperoleh yaitu Experiential Learning berbantuan origami efektif terhadap kemampuan keruangan siswa kelas VIII. AbstractThis experiment research aims to determine the effectiveness of Experiential Learning with Origami to the students’s spatial abilities by the criteria of effectiveness. The population of this research is students of grade VIII of SMP Negeri 3 Colomadu 2012/2013 academic year. Independent variables used in this research are learning by Experiential Learning with origami and student’s motivation. While the dependent variable is the student’s spatial abilities. This research is using documentation, spatial abilities’s test, dan motivation’s scale for collecting data method. Result of this research are: (1 proportion test show that the experiment group has reached mastering of learning clasically and personally; (2 result of spatial ablities’s post test in experiment group better than control group; (3 result of regretion shows that student�

DNA level and stereologic estimates of nuclear volume in squamous cell carcinomas of the uterine cervix. A comparative study with analysis of prognostic impact

DEFF Research Database (Denmark)

Sørensen, Flemming Brandt; Bichel, P; Jakobsen, A

1992-01-01

Grading of malignancy in squamous cell carcinomas of the uterine cervix is based on qualitative, morphologic examination and suffers from poor reproducibility. Using modern stereology, unbiased estimates of the three-dimensional, volume-weighted mean nuclear volume (nuclear vv), were obtained...... in pretreatment biopsies from 51 patients treated for cervical cancer in clinical Stages I through III (mean age of 56 years, follow-up period greater than 5 years). In addition, conventional, two-dimensional morphometric estimates of nuclear and mitotic features were obtained. DNA indices (DI) were estimated...

Neurotology findings in patients with diagnosis of vascular loop of cranial nerves VIII in magnetic resonance imaging

Directory of Open Access Journals (Sweden)

Grocoske, Francisco Luiz Busato

Full Text Available Introduction: The vascular compression by redundant vessels under the VIII cranial nerves has been studied since the 80's, and many authors proposed correlations between the compression and the otoneurological findings (vertigo, tinnitus, hypoacusis, audiometry and electrophysiological findings. Objective: Analyze and correlate the different signs and otoneurological symptoms, the audiological findings and its incidence over individuals with Vascular Loop (VL diagnosis of VIII cranial nerves by magnetic resonance imaging (MRI. Method: Retrospective study through the analysis of medical records of 47 patients attended in the otoneurology clinic of Clinical Hospital of UFPR. All the patients have MRI exams with compatible pictures of VL of the VIII cranial nerves. Results: The tinnitus was the most frequent symptom, in 83% of the patients, followed by hypoacusis (60% and vertigo (36%. The audiometry presented alterations in 89%, the brainstem evoked auditory potential in 33% and the vecto-electronystagmography in 17% of the patients. Was not found statistically significant relation between the buzz or hypoacusis, and the presence of VL in MRI. Only 36% of patients had complaints of vertigo, the main symptom described in theory of vascular compression of the VIII pair of nerve. As in the audiometry and in brainstem evoked auditory potential was not found a statistically significant relation between the exam and the presence of the VL in the RMI. Conclusion: The results show independence between the findings of the RMI, clinical picture and audiological results (p>0,05 suggesting that there are no exclusive and direct relation between the diagnosis of vascular loop in the MRI and the clinical picture matching.

Valor preditivo da expressão dos anticorpos Antifator VIII no carcinoma epidermóide do esôfago Predictive value of antifactor VIII antibody expression in squamous cell carcinoma of the esophagus

Directory of Open Access Journals (Sweden)

Sebastião Gonzaga Barbosa-Neto

2007-12-01

Full Text Available RACIONAL: O carcinoma epidermóide do esôfago apresenta alta mortalidade, baixo índice de diagnóstico precoce e altos custos nos tratamentos, com resultados freqüentemente desapontadores e prognóstico sombrio. O melhor entendimento das técnicas de biologia molecular com citofotometria de imagem, permitiu avançar no conhecimento das alterações na expressão das proteínas desse câncer. OBJETIVOS: Quantificar a expressão das proteínas envolvidas na angiogênese e correlacioná-las com variáveis clínico-patológicas. MÉTODOS: Com o uso da técnica de imunoistoquímica, citofotometria de imagem pelo sistema SAMBA, foram analisadas 29 amostras de carcinoma epidermóide do esôfago incluídas em blocos de parafina. Critérios clínicos como idade, sexo e histopatológicos do grau de diferenciação tumoral, tamanho e localização do tumor foram analisados. Os parâmetros analisados foram o índice de marcagem e a densidade óptica. O marcador utilizado foi o anticorpo anti-Fator VIII. RESULTADOS: Foi possível verificar que as expressões médias do marcador no índice de marcagem foram maiores que as da densidade óptica. Fator VIII apresentou leituras homogêneas. O índice de marcagem foi de 80,17+/-10,40 com P=0,073 e a densidade óptica 51,25+/-11,02 com P=0,245. CONCLUSÃO: A análise quantificação da expressão das proteínas envolvidas na angiogênese permite definir subgrupos de acordo com a diferenciação do carcinoma, estágio tumoral, tamanho e localização do tumor, porém não associa-se com o sexo e a idade dos pacientes, e a densidade óptica do Fator VIII não tem expressão significativa em nenhum dos subgrupos analisados.BACKGROUND: Squamous cell carcinoma of the esophagus exhibits high mortality rate, rare precocious diagnosis, and expensive treatments, presenting frequently disappointed results and poor prognosis. The better understanding about Molecular Biology techniques using cytophotometric imaging allowed

Volume reduction of dry active waste by use of a waste sorting table at the Brunswick nuclear power plant

International Nuclear Information System (INIS)

Snead, P.B.

1988-01-01

Carolina Power and Light Company's Brunswick nuclear power plant has been using a National Nuclear Corporation Model WST-18 Waste Sorting Table to monitor and sort dry active waste for segregating uncontaminated material as a means of low-level waste volume reduction. The WST-18 features 18 large-area, solid scintillation detectors arranged in a 3 x 6 array underneath a sorting/monitoring surface that is shielded from background radiation. An 11-week study at Brunswick showed that the use of the waste sorting table resulted in dramatic improvements in both productivity (man-hours expended per cubic foot of waste processed) and monitoring quality over the previous hand-probe frisking method. Use of the sorting table since the study has confirmed its effectiveness in volume reduction. The waste sorting table paid for its operation in volume reduction savings alone, without accounting for the additional savings from recovering reusable items

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.2--uranium mining and metallurgy sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 48 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the second one, the content is about uranium mining and metallurgy sub-volume

Penggunaan Media Presentase Microsoft Power Point Untuk Meningkatkan Hasil Belajar IPS Terpadu Pada Siswa Kelas VIII a SMP Negeri 2 Tanantovea

OpenAIRE

Hitler, Ahmad

2014-01-01

Permasalahan yang diangkat dalam penelitian adalah apakah dengan penggunaan media Presentase Microsoft Power Point pada mata pembelajaran IPS Terpadu dapat meningkatkan hasil belajar siswa kelas VIII A di SMP Negeri 2 Tanantovea. Penelitian ini bertujuan untuk meningkatkan hasil belajar siswa pada pokok bahasan Kolonialisme dan Imperialisme Barat di kelas VIII A SMP Negeri 2 Tanantovea. Penelitian ini dilakukan dalam 2 siklus, setiap siklus terdiri dari perencanaan, pelaksanaan tindakan, obs...

DNA level and stereologic estimates of nuclear volume in squamous cell carcinomas of the uterine cervix. A comparative study with analysis of prognostic impact

DEFF Research Database (Denmark)

Sørensen, Flemming Brandt; Bichel, P; Jakobsen, A

1992-01-01

Grading of malignancy in squamous cell carcinomas of the uterine cervix is based on qualitative, morphologic examination and suffers from poor reproducibility. Using modern stereology, unbiased estimates of the three-dimensional, volume-weighted mean nuclear volume (nuclear vv), were obtained...... in pretreatment biopsies from 51 patients treated for cervical cancer in clinical Stages I through III (mean age of 56 years, follow-up period greater than 5 years). In addition, conventional, two-dimensional morphometric estimates of nuclear and mitotic features were obtained. DNA indices (DI) were estimated...... carcinoma of the uterine cervix....

Draft Environmental Impact Statement on a proposed nuclear weapons nonproliferation policy concerning foreign research reactor spent nuclear fuel. Volume 1

International Nuclear Information System (INIS)

1995-03-01

The United States Department of Energy and United States Department of State are jointly proposing to adopt a policy to manage spent nuclear fuel from foreign research reactors. Only spent nuclear fuel containing uranium enriched in the United States would be covered by the proposed policy. The purpose of the proposed policy is to promote U.S. nuclear weapons nonproliferation policy objectives, specifically by seeking to reduce highly-enriched uranium from civilian commerce. Environmental effects and policy considerations of three Management Alternative approaches for implementation of the proposed policy are assessed. The three Management Alternatives analyzed are: (1) acceptance and management of the spent nuclear fuel by the Department of Energy in the United States, (2) management of the spent nuclear fuel at one or more foreign facilities (under conditions that satisfy United States nuclear weapons nonproliferation policy objectives), and (3) a combination of components of Management Alternatives 1 and 2 (Hybrid Alternative). A No Action Alternative is also analyzed. For each Management Alternative, there are a number of alternatives for its implementation. For Management Alternative 1, this document addresses the environmental effects of various implementation alternatives such as varied policy durations, management of various quantities of spent nuclear fuel, and differing financing arrangements. Environmental impacts at various potential ports of entry, along truck and rail transportation routes, at candidate management sites, and for alternate storage technologies are also examined. For Management Alternative 2, this document addresses two subalternatives: (1) assisting foreign nations with storage; and (2) assisting foreign nations with reprocessing of the spent nuclear fuel. Management Alternative 3 analyzes a hybrid alternative. This document is Vol. 1 of 2 plus summary volume

Leadership Handbook for the Armor Officer. Volume 1. Thoughts on Leadership

Science.gov (United States)

1986-01-01

34 Shakespeare "King Henry the VIII" (1612) 2-14 1 -4.. *4 * 4l& MISSION-TYPE ORDERS General Bruce C. Clarke, United States Army In Wbrld War II, those who... Hamlet IN ANY POSSIBLE nuclear war, as in past wars with conventional weapons, loss of sleep by soldiers--especially those in key staff and command...and sabotage. Several hamlets comprise Son My. These include Ta Cung, My 11hi, Co Lucy, and My Lai. These hamlets were assaulted by A/3-1 Infantry, B/4

Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume IV. Commercial potential

Energy Technology Data Exchange (ETDEWEB)

1980-06-01

This volume of the Nonproliferation Alternative Systems Assessment Program (NASAP) report provides time and cost estimates for positioning new nuclear power systems for commercial deployment. The assessment also estimates the rates at which the new systems might penetrate the domestic market, assuming the continuing viability of the massive light-water reactor network that now exists worldwide. This assessment does not recommend specific, detailed program plans and budgets for individual systems; however, it is clear from this analysis that any of the systems investigated could be deployed if dictated by national interest.

Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume IV. Commercial potential

International Nuclear Information System (INIS)

1980-06-01

This volume of the Nonproliferation Alternative Systems Assessment Program (NASAP) report provides time and cost estimates for positioning new nuclear power systems for commercial deployment. The assessment also estimates the rates at which the new systems might penetrate the domestic market, assuming the continuing viability of the massive light-water reactor network that now exists worldwide. This assessment does not recommend specific, detailed program plans and budgets for individual systems; however, it is clear from this analysis that any of the systems investigated could be deployed if dictated by national interest

Significantly improved surface morphology of N-polar GaN film grown on SiC substrate by the optimization of V/III ratio

Science.gov (United States)

Deng, Gaoqiang; Zhang, Yuantao; Yu, Ye; Yan, Long; Li, Pengchong; Han, Xu; Chen, Liang; Zhao, Degang; Du, Guotong

2018-04-01

In this paper, N-polar GaN films with different V/III ratios were grown on vicinal C-face SiC substrates by metalorganic chemical vapor deposition. During the growth of N-polar GaN film, the V/III ratio was controlled by adjusting the molar flow rate of ammonia while keeping the trimethylgallium flow rate unchanged. The influence of the V/III ratio on the surface morphology of N-polar GaN film has been studied. We find that the surface root mean square roughness of N-polar GaN film over an area of 20 × 20 μm2 can be reduced from 8.13 to 2.78 nm by optimization of the V/III ratio. Then, using the same growth conditions, N-polar InGaN/GaN multiple quantum wells (MQWs) light-emitting diodes (LEDs) were grown on the rough and the smooth N-polar GaN templates, respectively. Compared with the LED grown on the rough N-polar GaN template, dramatically improved interface sharpness and luminescence uniformity of the InGaN/GaN MQWs are achieved for the LED grown on the smooth N-polar GaN template.

Mechanical Behaviour of Materials Volume II Fracture Mechanics and Damage

CERN Document Server

François, Dominique; Zaoui, André

2013-01-01

Designing new structural materials, extending lifetimes and guarding against fracture in service are among the preoccupations of engineers, and to deal with these they need to have command of the mechanics of material behaviour. This ought to reflect in the training of students. In this respect, the first volume of this work deals with elastic, elastoplastic, elastoviscoplastic and viscoelastic behaviours; this second volume continues with fracture mechanics and damage, and with contact mechanics, friction and wear. As in Volume I, the treatment links the active mechanisms on the microscopic scale and the laws of macroscopic behaviour. Chapter I is an introduction to the various damage phenomena. Chapter II gives the essential of fracture mechanics. Chapter III is devoted to brittle fracture, chapter IV to ductile fracture and chapter V to the brittle-ductile transition. Chapter VI is a survey of fatigue damage. Chapter VII is devoted to hydogen embrittlement and to environment assisted cracking, chapter VIII...

Stereological estimates of nuclear volume and other quantitative variables in supratentorial brain tumors. Practical technique and use in prognostic evaluation

DEFF Research Database (Denmark)

Sørensen, Flemming Brandt; Braendgaard, H; Chistiansen, A O

1991-01-01

The use of morphometry and modern stereology in malignancy grading of brain tumors is only poorly investigated. The aim of this study was to present these quantitative methods. A retrospective feasibility study of 46 patients with supratentorial brain tumors was carried out to demonstrate...... the practical technique. The continuous variables were correlated with the subjective, qualitative WHO classification of brain tumors, and the prognostic value of the parameters was assessed. Well differentiated astrocytomas (n = 14) had smaller estimates of the volume-weighted mean nuclear volume and mean...... nuclear profile area, than those of anaplastic astrocytomas (n = 13) (2p = 3.1.10(-3) and 2p = 4.8.10(-3), respectively). No differences were seen between the latter type of tumor and glioblastomas (n = 19). The nuclear index was of the same magnitude in all three tumor types, whereas the mitotic index...

DNA level and stereologic estimates of nuclear volume in squamous cell carcinomas of the uterine cervix. A comparative study with analysis of prognostic impact

DEFF Research Database (Denmark)

Sørensen, Flemming Brandt; Bichel, P; Jakobsen, A

1992-01-01

Grading of malignancy in squamous cell carcinomas of the uterine cervix is based on qualitative, morphologic examination and suffers from poor reproducibility. Using modern stereology, unbiased estimates of the three-dimensional, volume-weighted mean nuclear volume (nuclear vv), were obtained...... in pretreatment biopsies from 51 patients treated for cervical cancer in clinical Stages I through III (mean age of 56 years, follow-up period greater than 5 years). In addition, conventional, two-dimensional morphometric estimates of nuclear and mitotic features were obtained. DNA indices (DI) were estimated...... of nuclear vv were only of marginal prognostic significance (2P = 0.07). However, Cox multivariate regression analysis showed independent prognostic value of patient age and nuclear vv along with clinical stage and DI. All other investigated variables were rejected from the model. A prognostic index...

Synthesization of the Ar VIII 3s-3p beam-foil decay curve

International Nuclear Information System (INIS)

Lindgaard, A.; Veje, E.

1981-01-01

The beam-foil decay curve for the 3s-3p transition in Ar VIII has been simulated from experimentally determined relative initial level populations and transition probabilities calculated in the numerical Coulomb approximation. Good agreement is observed between simulated and measured decay curves. A discussion of the simulation is given. (Auth.)

Nuclear waste calorimeter for very large drums with 385 litres sample volume

Energy Technology Data Exchange (ETDEWEB)

Jossens, G.; Mathonat, C. [SETARAM Instrumentation, Caluire (France); Bachelet, F. [CEA Valduc, Is sur Tille (France)

2015-03-15

Calorimetry is a very precise and well adapted tool for the classification of drums containing nuclear waste material depending on their level of activities (low, medium, high). A new calorimeter has been developed by SETARAM Instrumentation and the CEA Valduc in France. This new calorimeter is designed for drums having a volume bigger than 100 liters. It guarantees high operator safety by optimizing drum handling and air circulation for cooling, and optimized software for direct measurement of the quantity of nuclear material. The LVC1380 calorimeter makes it possible to work over the range 10 to 3000 mW, which corresponds to approximately 0.03 to 10 g of tritium or 3 to 955 g of {sup 241}Pu in a volume up to 385 liters. This calorimeter is based on the heat flow measurement using Peltier elements which surround the drum in the 3 dimensions and therefore measure all the heat coming from the radioactive stuff whatever its position inside the drum. Calorimeter's insulating layers constitute a thermal barrier designed to filter disturbances until they represent less than 0.001 Celsius degrees and to eliminate long term disturbances associated, for example, with laboratory temperature variations between day and night. A calibration device based on Joule effect has also been designed. Measurement time has been optimized but remains long compared with other methods of measurement such as gamma spectrometry but its main asset is to have a good accuracy for low level activities.

Proceedings of the second US Department of Energy environmental control symposium. Volume 2. Nuclear energy, conservation, and solar energy

International Nuclear Information System (INIS)

1980-06-01

These proceedings document the presentations given at the Second Environmental Control Symposium. Symposium presentations highlighted environmental control activities which span the entire DOE. Volume II contains papers relating to: environmental control aspects of nuclear energy use and development; nuclear waste management; renewable energy sources; transportation and building conservation (fuel economy, gasohol, building standards, and industry); and geothermal energy, power transmission, and energy storage

Models of cognitive behavior in nuclear power plant personnel. A feasibility study: main report. Volume 2

International Nuclear Information System (INIS)

Woods, D.D.; Roth, E.M.; Hanes, L.F.

1986-07-01

This report contains the results of a feasibility study to determine if the current state of models human cognitive activities can serve as the basis for improved techniques for predicting human error in nuclear power plants emergency operations. Based on the answer to this questions, two subsequent phases of research are planned. Phase II is to develop a model of cognitive activities, and Phase III is to test the model. The feasibility study included an analysis of the cognitive activities that occur in emergency operations and an assessment of the modeling concepts/tools available to capture these cognitive activities. The results indicated that a symbolic processing (or artificial intelligence) model of cognitive activities in nuclear power plants is both desirable and feasible. This cognitive model can be built upon the computational framework provided by an existing artificial intelligence system for medical problem solving called Caduceus. The resulting cognitive model will increase the capability to capture the human contribution to risk in probabilistic risk assessments studies. Volume I summarizes the major findings and conclusions of the study. Volume II provides a complete description of the methods and results, including a synthesis of the cognitive activities that occur during emergency operations, and a literature review on cognitive modeling relevant to nuclear power plants. 112 refs., 10 figs

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.8--radiation research and its application sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 12 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the eighth one, the content is about radiation research and its application sub-volume

Haemophilia A: Database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene

Energy Technology Data Exchange (ETDEWEB)

Tuddenham, E.G.D. (Clinical Research Centre, Harrow (United Kingdom)); Cooper, D.N. (Thrombosis Research Inst., London (United Kingdom)); Gitschier, J. (Univ. of California, San Francisco (United States)); Higuchi, M.; Kazazian, H.H.; Antonarakis, S.E. (Johns Hopkins Univ., Baltimore (United States)); Hoyer, L.W. (American Red Cross, Rockville (United States)); Yoshioka, A. (Nara Medical Coll., Kashihara City (Japan)); Peake, I.R. (Royal Hallamshire Hospital, Sheffield (United Kingdom)); Schwaab, R. (Inst. fuer Klinische Biochemie der Univ. Bonn (West Germany)); Lavergne, J.M. (Hopital de Bicetre (France)); Giannelli, F. (Guy' s Hospital, London (United Kingdom))

1991-09-25

Mutations at the factor VIII gene locus causing Haemophilia A have now been identified in many patients from a many ethnic groups. Earlier studies used biased methods which detected repetitive mutations at a few CG dinucleotides. More recently rapid gene scanning methods have uncovered an extreme diversity of mutations. Over 80 different point mutations, 6 insertions, 7 small deletions, and 60 large deletions have been characterized. Repetitive mutation has been proved for at least 16 CpG sites. All nonsense mutations cause severe disease. Most missense mutations appear to cause instability of the protein, but some are associated with production of dysfunctional factor VIII molecules, thereby localizing functionally critical regions of the cofactor. Variable phenotype has been observed in association with three of the latter class of genotype. This catalogue of gene lesions in Haemophilia A will be updated annually.

Detection of Intracellular Factor VIII Protein in Peripheral Blood Mononuclear Cells by Flow Cytometry

Directory of Open Access Journals (Sweden)

Gouri Shankar Pandey

2013-01-01

Full Text Available Flow cytometry is widely used in cancer research for diagnosis, detection of minimal residual disease, as well as immune monitoring and profiling following immunotherapy. Detection of specific host proteins for diagnosis predominantly uses quantitative PCR and western blotting assays. In this study, we optimized a flow cytometry-based detection assay for Factor VIII protein in peripheral blood mononuclear cells (PBMCs. An indirect intracellular staining (ICS method was standardized using monoclonal antibodies to different domains of human Factor VIII protein. The FVIII protein expression level was estimated by calculating the mean and median fluorescence intensities (MFI values for each monoclonal antibody. ICS staining of transiently transfected cell lines supported the method's specificity. Intracellular FVIII protein expression was also detected by the monoclonal antibodies used in the study in PBMCs of five blood donors. In summary, our data suggest that intracellular FVIII detection in PBMCs of hemophilia A patients can be a rapid and reliable method to detect intracellular FVIII levels.

National Public Information Symposium on Peaceful Uses of Nuclear Energy, NUC Info'2000. Radioactive Waste Management and Site Restoration in Uranium Industry. Proceedings. Volume 1

International Nuclear Information System (INIS)

Dobos, Ion; Comsa, Olivia

2000-01-01

These proceedings published in two volumes contain materials presented at the National Public Information Symposium on Peaceful Uses of Nuclear Energy, NUC Info'2000, Radioactive Waste Management and Site Restoration in Uranium Industry, held on 5. September to 8. September 2000 at Baita Bihor, Romania. As the name of Symposium indicates, this manifestation is addressed not only to specialists but rather to the public at large. The proceedings are structured in 4 sections: 1. Management of radioactive waste arising from uranium mining, milling and decommissioning; 2. Uranium mine close-down; 3. Environmental restoration of uranium mining and milling sites; 4. Management of radioactive waste arising from nuclear applications. The first volume also contains an inaugural session dedicated to nuclear power, nuclear fuel cycle and development of uranium industry in Romania. The contributions in the first volume deal with the management of radioactive waste arising from uranium mining, milling and decommissioning and uranium mine close-out

Analysis of factor VIII gene inversions in 164 unrelated hemophilia A families

Energy Technology Data Exchange (ETDEWEB)

Vnencak-Jones, L.; Phillips, J.A. III; Janco, R.L. [Vanderbilt Univ. School of Medicine, Nashville, TN (United States)] [and others

1994-09-01

Hemophilia A is an X-linked recessive disease with variable phenotype and both heterogeneous and wide spread mutations in the factor VIII (F8) gene. As a result, diagnostic carrier or prenatal testing often relies upon laborious DNA linkage analysis. Recently, inversion mutations resulting from an intrachromosomal recombination between DNA sequences in one of two A genes {approximately}500 kb upstream from the F8 gene and a homologous A gene in intron 22 of the F8 gene were identified and found in 45% of severe hemophiliacs. We have analyzed banked DNA collected since 1986 from affected males or obligate carrier females representing 164 unrelated hemophilia A families. The disease was sporadic in 37%, familial in 54% and in 10% of families incomplete information was given. A unique deletion was identified in 1/164, a normal pattern was observed in 110/164 (67%), and 53/164 (32%) families had inversion mutations with 43/53 (81%) involving the distal A gene (R3 pattern) and 10/53 (19%) involving the proximal A gene (R2 pattern). While 19% of all rearrangements were R2, in 35 families with severe disease (< 1% VIII:C activity) all 16 rearrangements seen were R3. In 18 families with the R3 pattern and known activities, 16 (89%) had levels < 1%, with the remaining 2 families having {le} 2.4% activity. Further, 18 referrals specifically noted the production of inhibitors and 8/18 (45%) had the R3 pattern. Our findings demonstrate that the R3 inversion mutation patterns is (1) only seen with VIII:C activity levels of {le} 2.4%, (2) seen in 46% of families with severe hemophilia, (3) seen in 45% of hemophiliacs known to have inhibitors, (4) not correlated with sporadic or familial disease and (5) not in disequilibrium with the Bcl I or Taq I intron 18 or ST14 polymorphisms. Finally, in families positive for an inversion mutation, direct testing offers a highly accurate and less expensive alternative to DNA linkage analysis.

Proceedings of the second US Department of Energy environmental control symposium. Volume 2. Nuclear energy, conservation, and solar energy

Energy Technology Data Exchange (ETDEWEB)

None

1980-06-01

These proceedings document the presentations given at the Second Environmental Control Symposium. Symposium presentations highlighted environmental control activities which span the entire DOE. Volume II contains papers relating to: environmental control aspects of nuclear energy use and development; nuclear waste management; renewable energy sources; transportation and building conservation (fuel economy, gasohol, building standards, and industry); and geothermal energy, power transmission, and energy storage. (DMC)

Nuclear power experience

International Nuclear Information System (INIS)

1983-01-01

The International Conference on Nuclear Power Experience, organized by the International Atomic Energy Agency, was held at the Hofburg Conference Center, Vienna, Austria, from 13 to 17 September 1982. Almost 1200 participants and observers from 63 countries and 20 organizations attended the conference. The 239 papers presented were grouped under the following seven main topics: planning and development of nuclear power programmes; technical and economic experience of nuclear power production; the nuclear fuel cycle; nuclear safety experience; advanced systems; international safeguards; international co-operation. The proceedings are published in six volumes. The sixth volume contains a complete Contents of Volume 1 to 5, a List of Participants, Authors and Transliteration Indexes, a Subject Index and an Index of Papers by Number

The NJOY Nuclear Data Processing System: Volume 3, The GROUPR, GAMINR, and MODER modules

International Nuclear Information System (INIS)

MacFarlane, R.E.; Muir, D.W.

1987-10-01

The NJOY Nuclear Data Processing System is a comprehensive computer code package for producing pointwise and multigroup cross sections and related quantities from ENDF/B-IV, V, or VI evaluated nuclear data. A concise description of the code system and references to the ancestors of NJOY are given in Vol. 1 of this report. This volume describes the GROUPR module, which produces multigroup neutron interaction cross sections and group-to-group production cross sections for neutrons and photons; the GAMINR module, which produces multigroup photon-interaction cross sections and group-to-group matrices; and the MODER module, which converts ENDF/B and NJOY interface files back and forth between formatted (i.e., BCD, ASCII) and binary modes and performs several associated editing functions. 34 refs., 13 figs

Nuclear piping criteria for Advanced Light-Water Reactors, Volume 1--Failure mechanisms and corrective actions

International Nuclear Information System (INIS)

Anon.

1993-01-01

This WRC Bulletin concentrates on the major failure mechanisms observed in nuclear power plant piping during the past three decades and on corrective actions taken to minimize or eliminate such failures. These corrective actions are applicable to both replacement piping and the next generation of light-water reactors. This WRC Bulletin was written with the objective of meeting a need for piping criteria in Advanced Light-Water Reactors, but there is application well beyond the LWR industry. This Volume, in particular, is equally applicable to current nuclear power plants, fossil-fueled power plants, and chemical plants including petrochemical. Implementation of the recommendations for mitigation of specific problems should minimize severe failures or cracking and provide substantial economic benefit. This volume uses a case history approach to high-light various failure mechanisms and the corrective actions used to resolve such failures. Particular attention is given to those mechanisms leading to severe piping failures, where severe denotes complete severance, large ''fishmouth'' failures, or long throughwall cracks releasing a minimum of 50 gpm. The major failure mechanisms causing severe failure are erosion-corrosion and vibrational fatigue. Stress corrosion cracking also has been a common problem in nuclear piping systems. In addition thermal fatigue due to mixing-tee and to thermal stratification also is discussed as is microbiologically-induced corrosion. Finally, water hammer, which represents the ultimate in internally-generated dynamic high-energy loads, is discussed

Influence Model Assisted Learning Cycle Mind Map to Achievement Physics Laboratory Judging from the performance Grade VIII SMPN 1 Rejoso Pasuruan

OpenAIRE

Ary Analisa Rahma

2014-01-01

Pengaruh Model Siklus Belajar Berbantuan Mind Map terhadap Prestasi Belajar Fisika Ditinjau dari Kinerja Laboratorium Siswa Kelas VIII SMPN 1 Rejoso Kabupaten Pasuruan Abstract: This study aimed to examine the effect of the learning cycle models aided the mind map on the learning achievement in terms of the performance of laboratory physics class VIII student on light material in SMP Negeri 1 Rejoso Pasuruan. This study is a quasi-experimental research. The research design used is a 2 x 2...

Efeitos de humor no poema VIII de Catulo

Directory of Open Access Journals (Sweden)

Paulo Sérgio Vasconcellos

1997-12-01

Full Text Available Neste artigo apresenta-se uma contribuição ao estudo dos efeitos de humor no poema VIII de Catulo; de fato, além do metro dessa composição e de outros elementos criadores de distanciamento irônico que os estudiosos têm apontado, um outro aspecto de sua forma, ainda pouco percebido, guia a leitura para essa interpretação: o jogo, a maneira de anagrama imperfeito (o “hipograma”, ou, mais precisamente, “criptograma”, de Saussure, com os sons do nome da amada, aparentemente calado. E mais uma das maneiras com que o poeta elabora a jocosa diferença entre o que se diz e o que, sentido e reprimido, deixa-se, porém, transparecer.

Progress report on nuclear science and technology in China (Vol.3). Proceedings of academic annual meeting of China Nuclear Society in 2013, No.7--pulse power technology and its application sub-volume

International Nuclear Information System (INIS)

2014-05-01

Progress report on nuclear science and technology in China (Vol. 3) includes 18 articles which are communicated on the third national academic annual meeting of China Nuclear Society. There are 10 books totally. This is the seventh one, the content is about pulse power technology and its application sub-volume

Manufacturing of nuclear power components in CDM

International Nuclear Information System (INIS)

Krishnan, J.; Jawale, S.B.

2002-01-01

Full text: In the nuclear research programme in India, Dr. H.J. Bhabha, the architecture of the Indian Nuclear programme felt a need for proto-type development and precision manufacturing facility to fulfill the requirements of mechanical components in establishing the manufacturing capability for the successful and self sustained nuclear programme. Centre for Design and Manufacture (CDM) hitherto known as CWS was established in 1964 to cater to the specific requirements of DAE and other associated units like ISRO, DRDO. Since then CDM has made multiple technological achievements and changes towards high quality products. The acquisition of up-to-date machines during High-Tech facility under VIII Plan project and Advance Precision Fabrication facility under IX Plan project has changed the capability of CDM towards CAD, CAM, CAE and CNC machining centres. Considering the rapid growth in the design and manufacturing, it was renamed as Centre for Design and Manufacture in March 2002, with the mission of quality output through group effort and team work

System of large transport containers for waste from dismantling light water and gas-cooled nuclear reactors. Volume 1

International Nuclear Information System (INIS)

Price, M.S.T.; Lafontaine, I.

1985-01-01

The purpose of this volume is to introduce the main types of nuclear reactor in the European Community (EC), select reference plants for further study, estimate the waste streams from the reference reactors, survey the transport regulations and assess existing containers

Models of cognitive behavior in nuclear power plant personnel. A feasibility study: summary of results. Volume 1

International Nuclear Information System (INIS)

Woods, D.D.; Roth, E.M.; Hanes, L.F.

1986-07-01

This report summarizes the results of a feasibility study to determine if the current state of models of human cognitive activities can serve as the basis for improved techniques for predicting human error in nuclear power plants emergency operations. Based on the answer to this question, two subsequent phases of research are planned. Phase II is to develop a model of cognitive activities, and Phase III is to test the model. The feasibility study included an analysis of the cognitive activities that occur in emergency operations and an assessment of the modeling concepts/tools available to capture these cognitive activities. The results indicated that a symbolic processing (or artificial intelligence) model of cognitive activities in nuclear power plants is both desirable and feasible. This cognitive model can be built upon the computational framework provided by an existing artificial intelligence system for medical problem solving, called Caduceus. The resulting cognitive model will increase the capability to capture the human contribution to risk in probabilistic risk assessment studies. Volume 1 summarizes the major findings and conclusions of the study. Volume 2 provides a complete description of the methods and results, including a synthesis of the cognitive activities that occur during emergency operations, and a literature review on cognitive modeling relevant to nuclear power plants. 19 refs

Improving motor reliability in nuclear power plants: Volume 1, Performance evaluation and maintenance practices

International Nuclear Information System (INIS)

Subudhi, M.; Gunther, W.E.; Taylor, J.H.; Sugarman, A.C.; Sheets, M.W.

1987-11-01

This report constitutes the first of the three volumes under this NUREG. The report presents recommendations for developing a cost-effective program for performance evaluation and maintenance of electric motors in nuclear power plants. These recommendations are based on current industry practices, available techniques for monitoring degradation in motor components, manufacturer's recommendations, operating experience, and results from two laboratory tests on aged motors. Two laboratory test reports on a small and a large motor are presented in separate volumes of this NUREG. These provide the basis for the various functional indicators recommended for maintenance programs in this report. The overall preventive maintenance program is separated into two broad areas of activity aimed at mitigating the potential effects of equipment aging: Performance Evaluation and Equipment Maintenance. The latter involves actually maintaining the condition of the equipment while the former involves those activities undertaken to monitor degradation due to aging. These monitoring methods are further categorized into periodic testing, surveillance testing, continuous monitoring and inspections. This study focuses on the methods and procedures for performing the above activities to maintain the motors operationally ready in a nuclear facility. This includes an assessment of various functional indicators to determine their suitability for trending to monitor motor component condition. The intrusiveness of test methods and the present state-of-the-art for using the test equipment in a plant environment are discussed. In conclusion, implementation of the information provided in this report, will improve motor reliability in nuclear power plants. The study indicates the kinds of tests to conduct, how and when to conduct them, and to which motors the tests should be applied. 44 refs., 12 figs., 13 tabs

High integrity software for nuclear power plants: Candidate guidelines, technical basis and research needs. Executive summary: Volume 1

International Nuclear Information System (INIS)

Seth, S.; Bail, W.; Cleaves, D.; Cohen, H.; Hybertson, D.; Schaefer, C.; Stark, G.; Ta, A.; Ulery, B.

1995-06-01

The work documented in this report was performed in support of the US Nuclear Regulatory Commission to examine the technical basis for candidate guidelines that could be considered in reviewing and evaluating high integrity computer software used in the safety systems of nuclear power plants. The framework for the work consisted of the following software development and assurance activities: requirements specification; design; coding; verification and validation, including static analysis and dynamic testing; safety analysis; operation and maintenance; configuration management; quality assurance; and planning and management. Each activity (framework element) was subdivided into technical areas (framework subelements). The report describes the development of approximately 200 candidate guidelines that span the entire range of software life-cycle activities; the assessment of the technical basis for those candidate guidelines; and the identification, categorization and prioritization of research needs for improving the technical basis. The report has two volumes: Volume 1, Executive Summary, includes an overview of the framework and of each framework element, the complete set of candidate guidelines, the results of the assessment of the technical basis for each candidate guideline, and a discussion of research needs that support the regulatory function; Volume 2 is the main report

Nuclear Regulatory Commission Issuances: Opinions and decisions of the Nuclear Regulatory Commission with selected orders. Progress report, January 1, 1996--June 30, 1996. Volume 43, pages 1-358

International Nuclear Information System (INIS)

1997-01-01

The hardbound edition of the Nuclear Regulatory Issuances is a final compilation of the monthly issuances. It includes all legal precedents for the agency within a six month period. This is the forty-third volume of issuances

Nuclear Regulatory Commission Issuances: Opinions and decisions of the Nuclear Regulatory Commission with selected orders. Progress report, January 1, 1996--June 30, 1996. Volume 43, pages 1-358

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-05-01

The hardbound edition of the Nuclear Regulatory Issuances is a final compilation of the monthly issuances. It includes all legal precedents for the agency within a six month period. This is the forty-third volume of issuances.

Staining for factor VIII related antigen and Ulex europaeus agglutinin I (UEA-I) in 230 tumours. An assessment of their specificity for angiosarcoma and Kaposi's sarcoma.

Science.gov (United States)

Leader, M; Collins, M; Patel, J; Henry, K

1986-11-01

In this study we examined the staining reactivity of commercially available antisera to factor VIII related antigen (F VIII RAg) and Ulex europaeus agglutinin I (UEA-I) on sections from 230 formalin fixed paraffin embedded tumours. These included 196 sarcomas, 20 carcinomas and 14 angiomas. All angiomas showed positive staining for F VIII RAg; all carcinomas showed negative staining; the vasoformative areas of all angiosarcomas stained positively but only four of six angiosarcomas showed positive staining of their solid areas; of seven Kaposi's sarcomas, all showed positive staining of vessels and six showed positive staining of the spindle cell component. In the remaining 181 non-vascular sarcomas there was a false positive result in four tumours (2.2%), three of which had a history of irradiation. Pre-radiotherapy biopsies of these three tumours stained negatively with anti-F VIII RAg. UEA-I was demonstrated in all the angiomas studied, in all angiosarcomas (including the solid components) and in well-formed vessels of all Kaposi's sarcomas, but only in the spindle cell component of 3/6. However, there was an unacceptably high rate of false positive staining amongst the carcinomas and non-vascular sarcomas. In conclusion, F VIII RAg is a specific but not a sensitive marker of angiosarcomas; UEA-I is a sensitive but not a specific marker of angiosarcomas.

Anterior Inferior Cerebellar Arteries Juxtaposed with the Internal Acoustic Meatus and Their Relationship to the Cranial Nerve VII/VIII Complex.

Science.gov (United States)

Alonso, Fernando; Kassem, Mohammad W; Iwanaga, Joe; Oskouian, Rod J; Loukas, Marios; Demerdash, Amin; Tubbs, R Shane

2017-08-16

Vascular loops in the cerebellopontine angle (CPA) and their relationship to cranial nerves have been used to explain neurological symptoms. The anterior inferior cerebellar artery (AICA) has variable branches producing vascular loops that can compress the facial cranial nerve (CN) VII and vestibulocochlear (CN VIII) nerves. AICA compression of the facial-vestibulocochlear nerve complex can lead to various clinical presentations, including hemifacial spasm (HFS), tinnitus, and hemiataxia. The formation of arterial loops inside or outside of the internal auditory meatus (IAM) can cause abutment or compression of CN VII and CN VIII. Twenty-five (50 sides) fresh adult cadavers underwent dissection of the cerebellopontine angle in the supine position. In regard to relationships between the AICA and the nerves of the facial/vestibulocochlear complex, 33 arteries (66%) traveled in a plane between the facial/nervus intermedius nerves and the cochlear and vestibular nerves. Five arteries (10%) traveled below the CN VII/VIII complex, six (12%) traveled posterior to the nerve complex, four (8%) formed a semi-circle around the upper half of the nerve complex, and two (4%) traveled between and partially separated the nervus intermedius and facial nerve proper. Our study found that the majority of AICA will travel in a plane between the facial/nervus intermedius nerves and the cochlear and vestibular nerves. Although the relationship between the AICA and porus acusticus and AICA and the nerves of the CN VII/VIII complex are variable, based on our findings, some themes exist. Surgeons should consider these with approaches to the cerebellopontine angle.

Tartaglia’s science of weights and mechanics in the sixteenth century selections from quesiti et inventioni diverse books VII–VIII

CERN Document Server

Pisano, Raffaele

2016-01-01

This book presents a historical and scientific analysis as historical epistemology of the science of weights and mechanics in the sixteenth century, particularly as developed by Tartaglia in his Quesiti et inventioni diverse, Book VII and Book VIII (1546; 1554). In the early 16th century mechanics was concerned mainly with what is now called statics and was referred to as the Scientia de ponderibus, generally pursued by two very different approaches. The first was usually referred to as Aristotelian, where the equilibrium of bodies was set as a balance of opposite tendencies to motion. The second, usually referred to as Archimedean, identified statics with centrobarica, the theory of centres of gravity based on symmetry considerations. In between the two traditions the Italian scholar Niccolò Fontana, better known as Tartaglia (1500?–1557), wrote the treatise Quesiti et inventioni diverse (1546). This volume consists of three main parts. In the first, a historical excursus regarding Tartaglia’s lifetime,...

In vivo recovery and safety of human factor VIII product AAFACT in patients with haemophilia A

NARCIS (Netherlands)

Vossebeld, P. J. M.; Tissing, M. H.; van den Berg, H. M.; Leebeek, F. W. G.; de Goede-Bolder, A.; Novakova, I. R. O.; Gerrits, W. B. J.; Peters, M.; Koopman, M. M. W.; Faber, A.; Hiemstra, H.; Grob, P.; Strengers, P. F. W.

2003-01-01

AAFACT, a monoclonal purified, solvent/detergent treated human plasma-derived coagulation factor VIII concentrate obtained from plasma of voluntary, non-remunerated blood donors, is manufactured and marketed in the Netherlands by Sanquin Plasma Products since 1995. In a postmarketing surveillance

Innovative Approaches for Immune Tolerance to Factor VIII in the Treatment of Hemophilia A

Science.gov (United States)

Sherman, Alexandra; Biswas, Moanaro; Herzog, Roland W.

2017-01-01

Hemophilia A (coagulation factor VIII deficiency) is a debilitating genetic disorder that is primarily treated with intravenous replacement therapy. Despite a variety of factor VIII protein formulations available, the risk of developing anti-dug antibodies (“inhibitors”) remains. Overall, 20–30% of patients with severe disease develop inhibitors. Current clinical immune tolerance induction protocols to eliminate inhibitors are not effective in all patients, and there are no prophylactic protocols to prevent the immune response. New experimental therapies, such as gene and cell therapies, show promising results in pre-clinical studies in animal models of hemophilia. Examples include hepatic gene transfer with viral vectors, genetically engineered regulatory T cells (Treg), in vivo Treg induction using immune modulatory drugs, and maternal antigen transfer. Furthermore, an oral tolerance protocol is being developed based on transgenic lettuce plants, which suppressed inhibitor formation in hemophilic mice and dogs. Hopefully, some of these innovative approaches will reduce the risk of and/or more effectively eliminate inhibitor formation in future treatment of hemophilia A. PMID:29225598

METHODOLOGY OF THE DRUGS MARKET VOLUME MODELING ON THE EXAMPLE OF HEMOPHILIA A

OpenAIRE

N. B. Molchanova

2015-01-01

Hemophilia A is a serious genetic disease, which may lead to disability of a patient even in early ages without a required therapy. The only one therapeutic approach is a replacement therapy with drugs of bloodcoagulation factor VIII (FVIII). The modeling of coagulation drugs market volume will allow evaluation of the level of patients’ provision with a necessary therapy. Modeling of a “perfect” market of drugs and its comparison with the real one was the purpose of the study. During the mode...

Advanced training course on state systems of accounting for and control of nuclear materials. Volume II. Visual aids

International Nuclear Information System (INIS)

Sorenson, R.J.; Schneider, R.A.

1979-01-01

Purpose of the course was to train in the accounting and control of nuclear materials in a bulk processing facility, for international safeguards. The Exxon low enriched uranium fabrication plant is used as an example. This volume contains visual aids used for the presentation

PENGARUH PENGUASAAN KONSEP TEOREMA PYTHAGORAS TERHADAP KEMAMPUAN MENYELESAIKAN SOAL-SOAL BANGUN RUANG SISI DATAR PADA SISWA KELAS VIII MTS NEGERI BALANG-BALANG

Directory of Open Access Journals (Sweden)

Syahrida Zaerani

2017-12-01

Abstract: This study aims to determine the impact of the mastery of Pythagoras Theorem concepts on the ability of MTs Negeri Balang-Balang grade VIII students to solve polyhedron problems. This study is a quantitative research with ex post facto design. Statistical population consists of all grade VIII students in MTs Negeri Balang-Balang which was 204 students. The number of sampling used is 102 respondents taken by simple random sampling technique. The research instrument was a test related to Pythagorean an polyhedron problems. Descriptive and inferential statistics were performed as the statistical analysis. The descriptive analysis result shows that the mastery of Pythagoras Theorem concepts is within the category of ‘high’ and the ability of solving polyhedron problems is as well. The inferential statistical analysis using simple linear regression shows that there is an impact of the mastery of Pythagoras Theorem concepts on polyhedron problem solving ability of Grade VIII students of MTs Negeri Balang-Balang.

Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume VII. International perspectives

International Nuclear Information System (INIS)

1979-12-01

The purpose of this volume is to assess the proliferation vulnerabilities of the present deployment of civilian nuclear-power systems within the current nonproliferation regime and, in light of their prospective deployment, to consider technical and institutional measures and alternatives which may contribute to an improved regime in which nuclear power could play a significant part. An assessment of these measures must include consideration of their nonproliferation effectiveness as well as their bearing upon energy security, and their operational, economic, and political implications. The nature of these considerations can provide some measure of their likely acceptability to various nations. While any final assessment of such measures and alternatives would have to examine the circumstances particular to each nation, it is hoped that the more generic assessments conducted here will be useful in suggesting guidelines for developing an improved nonproliferation regime which also helps to meet nuclear-energy needs. One chapter outlines the existing nonproliferation regime, including the Treaty for the Non-Proliferation of Nuclear Weapons (NPT), International Atomic Energy Agency (IAEA) safeguards, bilateral and multilateral requirements for agreements of cooperation and transfers of technology, and existing provisons for sanctions for violation of nonproliferation commitments. The chapter then proceeds to an assessment of various alternatives for providing assurance of fuel supply in light of this current regime. Another chapter examines a set of technical and institutional measures and alternatives for various components of once-through and closed fuel cycles. The components of the once-through fuel cycle assessed are enrichment services and spent-fuel management; the components of closed fuel cycles assessed are reprocessing and plutonium management and fast-breeder reactor (FBR) deployment

Lithium ionophore VIII as an extraordinarily effective receptor for the strontium cation: Experimental and theoretical study

Czech Academy of Sciences Publication Activity Database

Makrlík, E.; Novák, Vít; Vaňura, P.; Bouř, Petr

2014-01-01

Roč. 1061, Mar 5 (2014), s. 110-113 ISSN 0022-2860 Institutional support: RVO:61388963 Keywords : strontium cation * lithium ionophore VIII * complexation * extraction and stability constants * DFT calculations * structures Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.602, year: 2014

VIII International Congress of Engineering Physics

International Nuclear Information System (INIS)

2017-01-01

The Physicist Engineering is a multidisciplinary profession in which an undergraduate student integrates and applies their knowledge of Physics, Mathematics, and Computing to adapt and innovate all kind of technologies, as well as to development and apply theoretical knowledge to different fields of science and engineering. A Physicist Engineer, supported by a solid preparation in science and engineering is available to study, analyze, identify, and solve problems in different fields of science and technology for industries, hospitals, research laboratories, institutes and governmental organizations focused on metrology, optics, energy, materials, instrumentation of sophisticated equipment. The Physicist Engineering bachelor degree is a national and international reference to encouraging all those students to apply knowledge through active participation in the operation, planning, and management of projects. The technological and scientific impact of a Physicist Engineering undergraduate and graduate students, as well as the tutorial of the research professor that are interested in Physics and Physics Engineering, may be found in a biennial event like the International Conference on Physicist Engineering, through the diffusion of both experimental and theoretical research and teaching. In order to promote and encourage strength academic goals among universities and research institutions, the International Conference on Physics Engineering Committee, integrated by a faculty meeting of the Universidad Autónoma Metropolitana, Campus Azcapotzalco, has decided to grant the VIII International Congress of Physics Engineering to the Universidad Autónoma de Yucatán, which is going to take place on Mérida, November 7 th to 11 th , 2016. This conference considers different topics as: Renewables Energies Engineering Materials Technology Nanotechnology Medical Physics Education in Physics Engineering Nuclear Engineering High Precision Instrumentation Atmosphere Physics

Recommended criteria for the evaluation of on-site nuclear power plant emergency plans, volume II: criteria

International Nuclear Information System (INIS)

1997-01-01

A critical review of existing Canadian and international nuclear power plant (NPP) emergency plans, evaluation criteria, and approaches has been conducted to provide AECB staff with information which can be used to assess the adequacy of NPP on-site emergency response plans. The results of this work are published in two volumes. Volume I, Basis Document, provides the reasons why certain requirements are in place. It also gives comprehensive references to various standards.Volume II, Criteria, contains the criteria which relate to on-site actions and their integration with control room activities and the roles of off-site responsible organizations. The recommended criteria provide information on what is required, and not on how to accomplish the requirements. The licensees are given the latitude to decide on the methods and processes needed to meet the requirements. The documents do not address NPP off-site plans and response capability, or the control room emergency operating procedures and response capability. This report contains only Volume II: Criteria. 55 refs., 2 tabs., 1 fig

Improving attitudes toward mathematics learning with problem posing in class VIII

Science.gov (United States)

Vionita, Alfha; Purboningsih, Dyah

2017-08-01

This research is classroom action research which is collaborated to improve student's behavior toward math and mathematics learning at class VIII by using problem posing approach. The subject of research is all of students grade VIIIA which consist of 32 students. This research has been held on two period, first period is about 3 times meeting, and second period is about 4 times meeting. The instrument of this research is implementation of learning observation's guidance by using problem posing approach. Cycle test has been used to measure cognitive competence, and questionnaire to measure the students' behavior in mathematics learning process. The result of research shows the students' behavior has been improving after using problem posing approach. It is showed by the behavior's criteria of students that has increasing result from the average in first period to high in second period. Furthermore, the percentage of test result is also improve from 68,75% in first period to 78,13% in second period. On the other hand, the implementation of learning observation by using problem posing approach has also improving and it is showed by the average percentage of teacher's achievement in first period is 89,2% and student's achievement 85,8%. These results get increase in second period for both teacher and students' achievement which are 94,4% and 91,11%. As a result, students' behavior toward math learning process in class VIII has been improving by using problem posing approach.

The Texts of the Agency's Co-operation Agreements with Regional Intergovernmental Organizations. The Agreement with the Agency for the Prohibition of Nuclear Weapons in Latin America

International Nuclear Information System (INIS)

1972-01-01

The text of the Agency's agreement for co-operation with the Agency for the Prohibition of Nuclear Weapons in Latin America is reproduced in this document for the information of all Members. The agreement entered into force on 3 October 1972 pursuant to Article VIII

Nuclear Regulatory Commission issuances. Volume 17, No. 3

International Nuclear Information System (INIS)

1983-03-01

This report contains the Issuances received during March 1983 from the Commission (CLI), the Atomic Safety and Licensing Appeal Boards (ALAB), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judge (ALJ), the Directors Decisions (DD), and the Denials of Petition for Rulemaking (DPRM). The Issuances concerned the following facilities: Three Mile Island Nuclear Station, Unit No. 1; Comanche Peak Steam Electric Station, Units 1 and 2; Vallecitos Nuclear Center; Floating Nuclear Power Plants; San Onofre Nuclear Generating Station, Units 2 and 3; Point Beach Nuclear Plant, Unit 1; Perry Nuclear Power Plant, Units 1 and 2; Shoreham Nuclear Power Station, Unit 1; Western New York Nuclear Service Center; Limerick Generating Station, Units 1 and 2; Seabrook Station, Units 1 and 2; Black Fox Station, Units 1 and 2; WmH Zimmer Nuclear Power Station, Unit 1; WPPSS Nuclear Project No. 1; Zion Nuclear Plant, Units 1 and 2; and South Texas Project, Units 1 and 2

Partial correction of a severe molecular defect in hemophilia A, because of errors during expression of the factor VIII gene

Energy Technology Data Exchange (ETDEWEB)

Young, M.; Antonarakis, S.E. [Univ. of Geneva (Switzerland); Inaba, Hiroshi [Tokyo Medical College (Japan)] [and others

1997-03-01

Although the molecular defect in patients in a Japanese family with mild to moderately severe hemophilia A was a deletion of a single nucleotide T within an A{sub 8}TA{sub 2} sequence of exon 14 of the factor VIII gene, the severity of the clinical phenotype did not correspond to that expected of a frameshift mutation. A small amount of functional factor VIII protein was detected in the patient`s plasma. Analysis of DNA and RNA molecules from normal and affected individuals and in vitro transcription/translation suggested a partial correction of the molecular defect, because of the following: (i) DNA replication/RNA transcription errors resulting in restoration of the reading frame and/or (ii) {open_quotes}ribosomal frameshifting{close_quotes} resulting in the production of normal factor VIII polypeptide and, thus, in a milder than expected hemophilia A. All of these mechanisms probably were promoted by the longer run of adenines, A{sub 10} instead of A{sub 8}TA{sub 2}, after the delT. Errors in the complex steps of gene expression therefore may partially correct a severe frameshift defect and ameliorate an expected severe phenotype. 36 refs., 6 figs.

Prospects and Challenges of Implementing the Hydrographic Region VIII Basin Plan

Directory of Open Access Journals (Sweden)

Nathalia Silva Duarte

2011-12-01

Full Text Available The current “National Water Law” states that water resources plans must be elaborated by basins, states, and for the country. This essay discusses the water management process considering federal and state legislations and their interrelations, for the purpose of elucidating the gaps found in them , aiming at their applicability to the system of water resources management within the CBH- Macaé and Ostras scope. It also discusses the construction and evolution process of the above-mentioned committee, and developments in the implementation of the Basin Plan of Hydrographic Region VIII.

Influence of V/III growth flux ratio on trap states in m-plane GaN grown by ammonia-based molecular beam epitaxy

International Nuclear Information System (INIS)

Zhang, Z.; Arehart, A. R.; Hurni, C. A.; Speck, J. S.; Ringel, S. A.

2012-01-01

Deep level transient spectroscopy (DLTS) and deep level optical spectroscopy (DLOS) were utilized to investigate the behavior of deep states in m-plane, n-type GaN grown by ammonia-based molecular beam epitaxy (NH 3 -MBE) as a function of systematically varied V/III growth flux ratios. Levels were detected at E C - 0.14 eV, E C - 0.21 eV, E C - 0.26 eV, E C - 0.62 eV, E C - 0.67 eV, E C - 2.65 eV, and E C - 3.31 eV, with the concentrations of several traps exhibiting systematic dependencies on V/III ratio. The DLTS spectra are dominated by traps at E C - 0.14 eV and E C - 0.67 eV, whose concentrations decreased monotonically with increasing V/III ratio and decreasing oxygen impurity concentration, and by a trap at E C - 0.21 eV that revealed no dependence of its concentration on growth conditions, suggestive of different physical origins. Higher concentrations of deeper trap states detected by DLOS with activation energies of E C - 2.65 eV and E C - 3.31 eV in each sample did not display measureable sensitivity to the intentionally varied V/III ratio, necessitating further study on reducing these deep traps through growth optimization for maximizing material quality of NH 3 -MBE grown m-plane GaN.

Nuclear fuels policy. Report of the Atlantic Council's Nuclear Fuels Policy Working Group

International Nuclear Information System (INIS)

Anon.

1976-01-01

This Policy Paper recommends the actions deemed necessary to assure that future U.S. and non-Communist countries' nuclear fuels supply will be adequate, considering the following: estimates of modest growth in overall energy demand, electrical energy demand, and nuclear electrical energy demand in the U.S. and abroad, predicated upon the continuing trends involving conservation of energy, increased use of electricity, and moderate economic growth (Chap. I); possibilities for the development and use of all domestic resources providing energy alternatives to imported oil and gas, consonant with current environmental, health, and safety concerns (Chap. II); assessment of the traditional energy sources which provide current alternatives to nuclear energy (Chap. II); evaluation of realistic expectations for additional future energy supplies from prospective technologies: enhanced recovery from traditional sources and development and use of oil shales and synthetic fuels from coal, fusion and solar energy (Chap. II); an accounting of established nuclear technology in use today, in particular the light water reactor, used for generating electricity (Chap. III); an estimate of future nuclear technology, in particular the prospective fast breeder (Chap. IV); current and projected nuclear fuel demand and supply in the U.S. and abroad (Chaps. V and VI); the constraints encountered today in meeting nuclear fuels demand (Chap. VII); and the major unresolved issues and options in nuclear fuels supply and use (Chap. VIII). The principal conclusions and recommendations (Chap. IX) are that the U.S. and other industrialized countries should strive for increased flexibility of primary energy fuel sources, and that a balanced energy strategy therefore depends on the secure supply of energy resources and the ability to substitute one form of fuel for another

National Public Information Symposium on Peaceful Uses of Nuclear Energy, NUC Info' 2000. Radioactive Waste Management and Site Restoration in Uranium Industry. Proceedings. Volume 2

International Nuclear Information System (INIS)

Dobos, Ion; Comsa, Olivia

2000-01-01

These proceedings published in two volumes contain materials presented at the National Public Information Symposium on Peaceful Uses of Nuclear Energy, NUC Info' 2000. Radioactive Waste Management and Site Restoration in Uranium Industry - held on 5th September to 8th September 2000 at Baita - Bihor, Romania. The proceedings are structured in 4 sections: 1. Management of radioactive wastes arising from uranium mining, milling and decommissioning; 2. Uranium mine closing down; 3. Environmental restoration of uranium mining and milling sites; 4. Management of radioactive wastes arising from nuclear applications. The contributions in this volume debate the issues of environment restoration at uranium ore mining and management of radioactive wastes resulted from nuclear applications

Radiological aspects of nuclear accident scenarios. Volume 1 real-time emergency response systems post-Chernobyl action

International Nuclear Information System (INIS)

Sinnaeve, J.

1991-01-01

In the event of a nuclear accident, there is a need for a rapid assessment of the resulting levels of environmental contamination in order to facilitate decisions on possible countermeasures. Volume 1 of this report covers the development of numerical models, in the form of software packages, to simulate atmospheric transport and deposition over various distances, and techniques for estimation of the resulting doses

Nuclear Fuels & Materials Spotlight Volume 4

Energy Technology Data Exchange (ETDEWEB)

I. J. van Rooyen,; T. M. Lillo; Y. Q. WU; P.A. Demkowicz; L. Scott; D.M. Scates; E. L. Reber; J. H. Jackson; J. A. Smith; D.L. Cottle; B.H. Rabin; M.R. Tonks; S.B. Biner; Y. Zhang; R.L. Williamson; S.R. Novascone; B.W. Spencer; J.D. Hales; D.R. Gaston; C.J. Permann; D. Anders; S.L. Hayes; P.C. Millett; D. Andersson; C. Stanek; R. Ali; S.L. Garrett; J.E. Daw; J.L. Rempe; J. Palmer; B. Tittmann; B. Reinhardt; G. Kohse; P. Ramuhali; H.T. Chien; T. Unruh; B.M. Chase; D.W. Nigg; G. Imel; J. T. Harris

2014-04-01

As the nation's nuclear energy laboratory, Idaho National Laboratory brings together talented people and specialized nuclear research capability to accomplish our mission. This edition of the Nuclear Fuels and Materials Division Spotlight provides an overview of some of our recent accomplishments in research and capability development. These accomplishments include: • The first identification of silver and palladium migrating through the SiC layer in TRISO fuel • A description of irradiation assisted stress corrosion testing capabilities that support commercial light water reactor life extension • Results of high-temperature safety testing on coated particle fuels irradiated in the ATR • New methods for testing the integrity of irradiated plate-type reactor fuel • Description of a 'Smart Fuel' concept that wirelessly provides real time information about changes in nuclear fuel properties and operating conditions • Development and testing of ultrasonic transducers and real-time flux sensors for use inside reactor cores, and • An example of a capsule irradiation test. Throughout Spotlight, you'll find examples of productive partnerships with academia, industry, and government agencies that deliver high-impact outcomes. The work conducted at Idaho National Laboratory helps to spur innovation in nuclear energy applications that drive economic growth and energy security. We appreciate your interest in our work here at INL, and hope that you find this issue informative.

Nuclear Law Bulletin No. 92 - Volume 2013/2

International Nuclear Information System (INIS)

Chennoufi, F.; Pelzer, N.; Martirosyan, A.; Cook, H.; Fischer, D.; Clark, S.; Rothschild, T.; Touitou-Durand, F.; Guezou, O.; Manson, S.; Tafili, V.; Bolger, I.; Majerus, P.; Sieczak, K.; Sousa-Ferro, M.; Pospisil, M.; Skraban, A.; Portmann-Bochsler, F.; Shvytai, V.; Puig, D.; Durand, A.; Rivera, S.; Reyners, P.; Ryan-Taix, V.

2013-01-01

The Nuclear Law Bulletin is a unique international publication for both professionals and academics in the field of nuclear law. It provides authoritative and comprehensive information on nuclear law developments. Published twice a year in both English and French, it features topical articles written by renowned legal experts, covers nuclear legislative developments worldwide and reports on relevant case law, bilateral and international agreements and regulatory activities of international organisations. The topical articles of this issue deal with: - Uranium mining and production: A legal perspective on regulating an important resource by Lisa Thiele; - Turkish nuclear legislation: Developments for a nuclear newcomer by Erinc Ercan and Horst Schneider; - Nuclear law and environmental law in the licensing of nuclear installations by Christian Raetzke

Obtenção e caracterização de anticorpo monoclonal murino anti-fator VIII da coagulação sangüínea Attainment and characterization of murine monoclonal anti-factor VIII antibodies

Directory of Open Access Journals (Sweden)

Rosana Rossi-Ferreira

2006-06-01

Full Text Available Entre os avanços da engenharia celular e biotecnologia nas últimas décadas, destaca-se a produção de anticorpos monoclonais murinos (AcMm utilizados no aprimoramento diagnóstico nas rotinas laboratoriais. A produção de fator VIII de alta pureza sempre foi o desejo e a preocupação das indústrias de hemoderivados para tratamento de pacientes portadores de hemofilia A, porém este produto inexiste no Brasil, sendo necessária sua obtenção no mercado internacional a custos elevados. O trabalho tem por objetivo a produção de AcMm anti-fator VIII humano (FVIII H através da expansão dos clones e caracterização imunoquímica do anticorpo. Camundongos Balb/c foram imunizados com FVIII H purificado como também proveniente de crioprecipitado e as células esplênicas dos animais foram fusionadas com células mielomatosas murinas segundo o método descrito por Kohler e Milstein para produção de híbridos em cultura. Foram testados 1.983 híbridos dos quais 105 foram submetidos à clonagem. Destes, 39 obtiveram monoclonalidade e 7 destes clones foram caracterizados através de técnicas de immunoblotting. Foram submetidas à purificação por cromatografia três imunoglobulinas de diferentes classes pertencentes aos clones LAMB1-10A1A4, LAMB1-17A1A1 e LAMB1-24A2A1. A imunoglobulina purificada pertencente ao clone LAMB1-10A1A4 foi adsorvida em coluna de imunoafinidade para purificação de concentrado de FVIII proveniente de crioprecipitado plasmático.Among the advances in cellular engineering and biotechnology over the last decades, the production of murine monoclonal antibodies (AcMm, used to improve laboratory diagnoses, stands out. The production of very pure factor VIII has always been a concern of suppliers of blood products to treat patients with hemophilia A and this product is still not produced in Brazil. Hence, it can only be attained on the international market at a high cost. The aim of this work was to produce AcMm anti

User's guide for PRISM (Plant Risk Status Information Management System) Arkansas Nuclear One-Unit 1: Volume 1, Program for inspectors

International Nuclear Information System (INIS)

Campbell, D.J.; Guthrie, V.H.; Kirchner, J.R.; Kirkman, J.Q.; Paula, H.M.; Ellison, B.C.; Dycus, F.M.; Farquharson, J.A.; Flanagan, G.F.

1988-03-01

This user's guide is a two-volume document designed to teach NRC inspectors and NRC regulators how to access probabilistic risk assessment information from the two Plant Risk Status Information Management System (PRISIM) programs developed for Arkansas Nuclear One -- Unit One (ANO-1). This document, Volume 1, describes how the PRA information available in Version 1.0 of PRISIM is useful for planning inspections. Using PRISIM, inspectors can quickly access PRA information and use that information to update risk analysis results, reflecting a plant's status at any particular time. Both volumes are stand-alone documents, and each volume presents several sample computer sessions designed to lead the user through a variety of PRISIM applications used to obtain PRA-related information for monitoring and controlling plant risk

Volume fraction prediction in biphasic flow using nuclear technique and artificial neural network

International Nuclear Information System (INIS)

Salgado, Cesar M.; Brandao, Luis E.B.

2015-01-01

The volume fraction is one of the most important parameters used to characterize air-liquid two-phase flows. It is a physical value to determine other parameters, such as the phase's densities and to determine the flow rate of each phase. These parameters are important to predict the flow pattern and to determine a mathematical model for the system. To study, for example, heat transfer and pressure drop. This work presents a methodology for volume fractions prediction in water-gas stratified flow regime using the nuclear technique and artificial intelligence. The volume fractions calculate in biphasic flow systems is complex and the analysis by means of analytical equations becomes very difficult. The approach is based on gamma-ray pulse height distributions pattern recognition by means of the artificial neural network. The detection system uses appropriate broad beam geometry, comprised of a ( 137 Cs) energy gamma-ray source and a NaI(Tl) scintillation detector in order measure transmitted beam whose the counts rates are influenced by the phases composition. These distributions are directly used by the network without any parameterization of the measured signal. The ideal and static theoretical models for stratified regime have been developed using MCNP-X code, which was used to provide training, test and validation data for the network. The detector also was modeled with this code and the results were compared to experimental photopeak efficiency measurements of radiation sources. The proposed network could obtain with satisfactory prediction of the volume fraction in water-gas system, demonstrating to be a promising approach for this purpose. (author)

Volume fraction prediction in biphasic flow using nuclear technique and artificial neural network

Energy Technology Data Exchange (ETDEWEB)

Salgado, Cesar M.; Brandao, Luis E.B., E-mail: otero@ien.gov.br, E-mail: brandao@ien.gov.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

2015-07-01

The volume fraction is one of the most important parameters used to characterize air-liquid two-phase flows. It is a physical value to determine other parameters, such as the phase's densities and to determine the flow rate of each phase. These parameters are important to predict the flow pattern and to determine a mathematical model for the system. To study, for example, heat transfer and pressure drop. This work presents a methodology for volume fractions prediction in water-gas stratified flow regime using the nuclear technique and artificial intelligence. The volume fractions calculate in biphasic flow systems is complex and the analysis by means of analytical equations becomes very difficult. The approach is based on gamma-ray pulse height distributions pattern recognition by means of the artificial neural network. The detection system uses appropriate broad beam geometry, comprised of a ({sup 137}Cs) energy gamma-ray source and a NaI(Tl) scintillation detector in order measure transmitted beam whose the counts rates are influenced by the phases composition. These distributions are directly used by the network without any parameterization of the measured signal. The ideal and static theoretical models for stratified regime have been developed using MCNP-X code, which was used to provide training, test and validation data for the network. The detector also was modeled with this code and the results were compared to experimental photopeak efficiency measurements of radiation sources. The proposed network could obtain with satisfactory prediction of the volume fraction in water-gas system, demonstrating to be a promising approach for this purpose. (author)

Properties of colloidal corrosion products and their effects on nuclear plants. Volume 1. Executive summary. Final report

International Nuclear Information System (INIS)

Matijevic, E.

1982-10-01

The properties of aqueous dispersions of finely divided oxides of iron, nickel, cobalt, chromium, and copper are described in overview fashion. More detailed aspects of this work will be found in a separate, larger report, NP-2606, Volume 2. The properties of these oxide corrosion products of importance to nuclear reactor water system technology are emphasized: adhesion, desorption, dissolution, transformation, and adsorption of dissolved species such as Co 60 ions. The work is fundamental to many LWR problems - radiation transport to piping surfaces, avoidance of crud buildup on nuclear fuel rods, decontamination and chemical cleaning of heat exchangers, and control of corrosion of piping

Structural Mimics of the [Fe]-Hydrogenase: A Complete Set for Group VIII Metals.

Science.gov (United States)

Barik, Chandan Kr; Ganguly, Rakesh; Li, Yongxin; Leong, Weng Kee

2018-06-18

A set of structural mimics of the [Fe]-hydrogenase active site comprising all the group VIII metals, viz., [M(2-NHC(O)C 5 H 4 N)(CO) 2 (2-S-C 5 H 4 N)], has been synthesized. They exist as a mixture of isomers in solution, and the relative stability of the isomers depends on the nature of the metal and the substituent at the 6-position of the pyridine ligand.

Stereological estimation of nuclear volume and other quantitative histopathological parameters in the prognostic evaluation of supraglottic laryngeal squamous cell carcinoma

DEFF Research Database (Denmark)

Sørensen, Flemming Brandt; Bennedbaek, O; Pilgaard, J

1989-01-01

The aim of this study was to investigate various approaches to the grading of malignancy in pre-treatment biopsies from patients with supraglottic laryngeal squamous cell carcinoma. The prospects of objective malignancy grading based on stereological estimation of the volume-weighted mean nuclear...... observers of the latter was poor in the material which consisted of 35 biopsy specimens. Unbiased estimates of nuclear Vv were on the average 385 microns3 (CV = 0.44), with more than 90% of the associated variance attributable to differences in nuclear Vv among individual lesions. Nuclear Vv was positively....... None of the investigated categorical and quantitative parameters (cutoff points = means) reached the level of significance with respect to prognostic value. However, nuclear Vv showed the best information concerning survival (2p = 0.08), and this estimator offers optimal features for objective...

Guidance for the application of an assessment methodology for innovative nuclear energy systems. INPRO manual - Overview of the methodology. Vol. 1 of 9 of the final report of phase 1 of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) including a CD-ROM comprising all volumes

International Nuclear Information System (INIS)

2008-11-01

The International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) was initiated in the year 2000, based on a resolution of the IAEA General Conference (GC(44)/RES/21). The main objectives of INPRO are (1) to help to ensure that nuclear energy is available to contribute in fulfilling energy needs in the 21st century in a sustainable manner, (2) to bring together both technology holders and technology users to consider jointly the international and national actions required to achieve desired innovations in nuclear reactors and fuel cycles; and (3) to create a forum to involve all relevant stakeholders that will have an impact on, draw from, and complement the activities of existing institutions, as well as ongoing initiatives at the national and international level. This document follows the guidelines of the INPRO report 'Methodology for the assessment of innovative nuclear reactors and fuel cycles, Report of Phase 1B (first part) of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO)', IAEA-TECDOC-1434 (2004), together with its previous report Guidance for the evaluation for innovative nuclear reactors and fuel cycles, Report of Phase 1A of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO), IAEA-TECDOC-1362 (2003). This INPRO manual is comprised of an overview volume (laid out in this report), and eight additional volumes (available on a CD-ROM attached to the inside back cover of this report) covering the areas of economics (Volume 2), infrastructure (Volume 3), waste management (Volume 4), proliferation resistance (Volume 5), physical protection (Volume 6), environment (Volume 7), safety of reactors (Volume 8), and safety of nuclear fuel cycle facilities (Volume 9). The overview volume sets out the philosophy of INPRO and a general discussion of the INPRO methodology. This overview volume discusses the relationship of INPRO with the UN concept of sustainability to demonstrate how the

Energy policy study. Volume 10. Nuclear power regulation

International Nuclear Information System (INIS)

Nikodem, Z.D.; Reynolds, A.W.; Clark, R.G.

1980-05-01

This report examines the programs for regulating the safety, design, and operation of domestic nuclear power plants. The first part of the study describes the Federal and State regulatory procedures. It describes the legal foundations for the Federal licensing process and the associated State regulatory activities. It then analyzes the aspects of these procedures that affect the cost and supply of nuclear-generated electricity. The second part of this study examines the effects of nuclear safety regulations on the planning and construction lead time for nuclear power stations, the cost of nuclear power, and, ultimately, the decision to invest in nuclear power

Nuclear Regulatory Commission Issuances. Opinions and decisions of the Nuclear Regulatory Commission with selected orders: July 1, 1992--December 31, 1992, Volume 36, Pages 1--396

Energy Technology Data Exchange (ETDEWEB)

1992-12-31

This is the thirty-sixth volume of issuances (1-396) of the Nuclear Regulatory Commission and its Atomic Safety and Licensing Boards, Administrative Law Judges, and Office Directors. It covers the period from July 1, 1992-December 31, 1992. Atomic Safety and Licensing Boards are authorized by Section 191 of the Atomic Energy Act of 1954. These Boards, comprised of three members conduct adjudicatory hearings on applications to construct and operate nuclear power plants and related facilities and issue initial decisions which, subject to internal review and appellate procedures, become the final Commission action with respect to those applications. Boards are drawn from the Atomic Safety and Licensing Board Panel, comprised of lawyers, nuclear physicists and engineers, environmentalists, chemists, and economists. The Atomic Energy Commission first established Licensing Boards in 1962 and the Panel in 1967.

Nuclear Law Bulletin No. 93, Volume 2014/1

International Nuclear Information System (INIS)

2014-01-01

The Nuclear Law Bulletin is a unique international publication for both professionals and academics in the field of nuclear law. It provides authoritative and comprehensive information on nuclear law developments. Published free online twice a year in both English and French, it features topical articles written by renowned legal experts, covers legislative developments worldwide and reports on relevant case law, bilateral and international agreements as well as regulatory activities of international organisations. Feature articles in this issue include: 'Progress towards a global nuclear liability regime'; 'The Convention on Supplementary Compensation for Nuclear Damage and participation by developing countries: A South African perspective'; 'Fusion energy and nuclear liability considerations'; and 'Nuclear energy and Indian society: Public engagement, risk assessment and legal frameworks'

IMPLIKASI YURIDIS PUTUSAN MK NOMOR 46/PUU- VIII/ 2010 TERHADAP AKTA KELAHIRAN ANAK LUAR KAWIN

Directory of Open Access Journals (Sweden)

Djumikasih Djumikasih

2014-08-01

Full Text Available Abstract This paper aims to identify and analyze what the juridical implications of the publication of the decision of the Constitutional Court No. 46/PUU-VIII / 2010 on Child Outside Marriage Deed which has been published by the Department of Population and Civil Registration prior to the establishment of the Constitutional Court's decision . The method used in this study is a normative juridical approach legislation. From the discussion, it can be concluded that the Constitutional Court 46/PUU-VIII/2010 Number of Tests on Article 43 paragraph ( 1 Marriage Act ( Act No. 1 of 1974 when viewed from the angle of legal certainty it will lead to legal certainty . But the decision will not have any juridical implications of the child's birth certificate that has been published outside of marriage and illegitimate child who was born before the date of February 17, 2012, as if enacted would be contrary to the principle of legality is interpreted Article 47 of the Law on the Constitutional Court and Article 28 ( i of the 1945 Constitution . Likewise, if the terms of the fairness and usefulness , especially for justice seekers / applicant , the timing of this decision is not fair and not useful , because although the Court granted the petition but the Constitutional Court can not be applied to her .   Key words: yuridical implication, birth certificate, children who are born outside of marriage   Abstrak   Tulisan ini bertujuan untuk mengetahui dan menganalisis apa implikasi yuridis dari terbitnya putusan MK Nomor 46/PUU-VIII/ 2010 terhadap Akta Anak Luar Kawin yang sudah diterbitkan oleh Dinas Kependudukan dan Catatan Sipil sebelum lahirnya putusan MK tersebut. Metode yang digunakan dalam penelitian ini adalah yuridis normative dengan pendekatan perundang-undangan. Dari pembahasan dapat disimpulkan bahwa Putusan MK Nomer 46/PUU-VIII/2010 tentang Pengujian terhadap Pasal 43 ayat (1 UU Perkawinan (UU NO 1 Tahun 1974 jika dilihat dari sudut kepastian

Guide for the evaluation of physical protection equipment. Book 2: Volumes IV--VIII

International Nuclear Information System (INIS)

Haberman, W.

1977-06-01

A guide for evaluating the performance of commercially available physical protection equipment has been prepared for use by U.S. NRC. Separate evaluation procedures are provided for each generic type of equipment contained in the companion document, Catalog of Physical Protection Equipment (NUREG-0274). Among the equipment parameters evaluated are sensitivity, area/volume of coverage, false/nuisance alarm rate, resistance to countermeasures, environmental requirements, installation parameters and maintenance. Four evaluation techniques are employed (inspections, analyses, demonstrations and tests); standard test equipment (both commercially available as well as developmental) to be used in the evaluation is listed. The following categories of equipment are covered: surveillance and alarm assessment components, contraband detection components, automated response components, general purpose display components, and general purpose communication components

Construction of a bibliographic information database for the nuclear science and engineering (VIII)

Energy Technology Data Exchange (ETDEWEB)

Kim, Tae Whan; Kim, Soon Ja; Kim, Young Min; Oh, Jeong Hun; Choi, Kwang [Korea Atomic Energy Research Institute, Taejon (Korea)

1998-12-01

The major goal of this project is to construct a database in nuclear science and engineering information materials, support the R and D activities of users in this field, finally to support KRISTAL(Korea Research Information for Science ad Technology Access Line)'s BD through the KREONet (Korea Research Environment Open Network), as one of the five national information networks. The contents of this project are as follows : 1) Materials selection and collection, 2) Indexing and abstract preparation, 3) Data input and transmission, and 4) document delivery service. In this seventh year, 35,000 record as total of inputted data, are added to the existing SATURN DB using the input system. These records are covered with the articles of nuclear-related core journals, proceedings, seminars, and research reports, etc. And using the Web, this project was important for users to get their needed information itself and to receive the materials of online requested information. And then it will give the chance users not only to promote the effectiveness of R and D activities, but also to obviate the duplicated research works. 1 tab. (Author)

Tranexamic acid combined with recombinant factor VIII increases clot resistance to accelerated fibrinolysis in severe hemophilia A

DEFF Research Database (Denmark)

Hvas, Anne-Mette; Sørensen, Hanne Thykjær; Norengaard, Lisbeth

2007-01-01

examined whether the clot stability in hemophiliacs could be improved by treatment with tranexamic acid (TXA) in combination with recombinant factor VIII (rFVIII). PATIENTS/METHODS: Baseline blood samples were obtained from eight males with severe hemophilia A. Thereafter, a bolus injection of r...

Hemophilia as a defect of the tissue factor pathway of blood coagulation: Effect of factors VIII and IX on factor X activation in a continuous-flow reactor

International Nuclear Information System (INIS)

Repke, D.; Gemmell, C.H.; Guha, A.; Turitto, V.T.; Nemerson, Y.; Broze, G.J. Jr.

1990-01-01

The effect of factors VIII and IX on the ability of the tissue factor-factor VIIa complex to activate factor X was studied in a continuous-flow tubular enzyme reactor. Tissue factor immobilized in a phospholipid bilayer on the inner surface of the tube was exposed to a perfusate containing factors VIIa, VIII, IX, and X flowing at a wall shear rate of 57, 300, or 1130 sec -1 . The addition of factors VIII and IX at their respective plasma concentrations resulted in a further 2 endash-to 3 endash fold increase. The direct activation of factor X by tissue factor-factor VIIa could be virtually eliminated by the lipoprotein-associated coagulation inhibitor. These results suggest that the tissue factor pathway, mediated through factors VIII and IX, produces significant levels of factor Xa even in the presence of an inhibitor of the tissue factor-factor VIIa complex; moreover, the activation is dependent on local shear conditions. These findings are consistent both with a model of blood coagulation in which initiation of the system results from tissue factor and with the bleeding observed in hemophilia

Radiological aspects of nuclear accident scenarios. Volume 2 the Rade-Aid system post-Chernobyl action

International Nuclear Information System (INIS)

Sinnaeve, J.

1991-01-01

In the event of a nuclear accident, there is a need for a rapid assessment of the resulting levels of environmental contamination in order to facilitate decisions on possible countermeasures. Volume 2 describes the RADE-AID project to develop a computer system which can be used to support the formulation of decisions on countermeasures following an accidental release of radionuclides. The system is intended as an aid following an actual accident and a tool for assistance in planning and training

Visualizing the Life and Legacy of Henry VIII: Guiding Students with Eight Types of Graphic Organizers

Science.gov (United States)

Gallavan, Nancy P.; Kottler, Ellen

2010-01-01

Delving into the life and legacy of Henry VIII is both complex and captivating. People seem compelled to learn more abut his critical contributions and controversial conduct that range from the significant to the scandalous. Reflecting on the history of the world would be incomplete without investigating the events and escapades associated with…

Nuclear Law Bulletin No. 94, Volume 2014/2

International Nuclear Information System (INIS)

2014-01-01

The Nuclear Law Bulletin is a unique international publication for both professionals and academics in the field of nuclear law. It provides subscribers with authoritative and comprehensive information on nuclear law developments. Published free online twice a year in both English and French, it features topical articles written by renowned legal experts, covers legislative developments worldwide and reports on relevant case law, bilateral and international agreements as well as regulatory activities of international organisations. Feature articles in this issue include 'Facilitating the entry into force and implementation of the Amendment to the Convention on the Physical Protection of Nuclear Material: Observations, challenges and benefits'; 'The legal status of nuclear power in Germany'; 'Challenges facing the insurance industry since the modernisation of the international nuclear third party liability regime'; 'Draft Federal Act of the Russian Federation, 'The Civil Liability for Nuclear Damage and its Financial Security''. (authors)

Acquired factor VIII inhibitor syndrome: A rare cause of hematuria

Directory of Open Access Journals (Sweden)

Muthuvel Seral Kannan

2015-01-01

Full Text Available A 50-year-old woman presented with gross hematuria for 1 month. Clinical examinations, laboratory investigations, ultrasound and contrast computed tomography were normal, except anemia. Cystoscopy revealed bloody efflux from the right side. Retrograde pyelogram showed filling defect in the renal pelvis and biopsy was inconclusive. Renal angiogram was normal. She developed ecchymosis on the right thigh and arm with elevated activated partial thromboplastin time. The partial thromboplastin time correction study and Bethesda study confirmed the presence of acquired factor VIII inhibitor (acquired hemophilia. With flexible ureterorenoscopy, the mass in the renal pelvis was removed and its histopathology revealed clotted blood. The patient was subsequently managed with steroids and Factor eight inhibitor bypass activity.

Nuclear Fuels & Materials Spotlight Volume 5

International Nuclear Information System (INIS)

Petti, David Andrew

2016-01-01

As the nation's nuclear energy laboratory, Idaho National Laboratory brings together talented people and specialized nuclear research capability to accomplish our mission. This edition of the Nuclear Fuels and Materials Division Spotlight provides an overview of some of our recent accomplishments in research and capability development. These accomplishments include: • Evaluation and modeling of light water reactor accident tolerant fuel concepts • Status and results of recent TRISO-coated particle fuel irradiations, post-irradiation examinations, high-temperature safety testing to demonstrate the accident performance of this fuel system, and advanced microscopy to improve the understanding of fission product transport in this fuel system. • Improvements in and applications of meso and engineering scale modeling of light water reactor fuel behavior under a range of operating conditions and postulated accidents (e.g., power ramping, loss of coolant accident, and reactivity initiated accidents) using the MARMOT and BISON codes. • Novel measurements of the properties of nuclear (actinide) materials under extreme conditions, (e.g. high pressure, low/high temperatures, high magnetic field) to improve the scientific understanding of these materials. • Modeling reactor pressure vessel behavior using the GRIZZLY code. • New methods using sound to sense temperature inside a reactor core. • Improved experimental capabilities to study the response of fusion reactor materials to a tritium plasma. Throughout Spotlight, you'll find examples of productive partnerships with academia, industry, and government agencies that deliver high-impact outcomes. The work conducted at Idaho National Laboratory helps spur innovation in nuclear energy applications that drive economic growth and energy security. We appreciate your interest in our work here at Idaho National Laboratory, and hope that you find this issue informative.

Waste isolation in the U.S., technical programs and public education. Volume 2 - low level waste, volume reduction methodologies and economics. Vol. 2

International Nuclear Information System (INIS)

Post, R.G.

1984-01-01

This volume presents information regarding low-level waste, volume reduction methodologies and economics. Topics include: public education on nuclear waste; economics of low-level waste management systems; operating experience with advanced volume reduction techniques; solidification of waste; operating experience with advanced volume reduction techniques--incineration; regional plans for the disposal of low-level waste; radwaste system modifications at nuclear power plants; operating experience with advanced volume reduction techniques--operations and on-site storage issues; and economic impact of 10CFR61

VIII All-Russian symposium on molecular liquid chromatography and capillary electrophoresis. Program. Summary of reports

International Nuclear Information System (INIS)

2001-01-01

Program and summary of reports of the VIII All-Russian symposium on molecular liquid chromatography and capillary electrophoresis are performed. The meeting took place 15-19 October, 2001 in Moscow. Many problems of liquid and ion exchange chromatography, capillary electrophoresis, thin-layer chromatography have been discussed extensively. Reports covering properties of sorbents and devices for chromatography are incorporated in the collection [ru

The Texts of the Instruments Concerning the Agency's Assistance to Mexico in Establishing a Nuclear Power Facility

Energy Technology Data Exchange (ETDEWEB)

NONE

1974-04-05

The texts of the Supply Agreement between the Agency and the Governments of Mexico and the United States of America, and of the Project Agreement between the Agency and the Government of Mexico concerning the Agency's assistance to that Government in establishing a nuclear power facility, are reproduced herein for the information of all Members. The Agreements entered into force on 12 February 1974, pursuant to Articles VIII and IX respectively.

The Texts of the Instruments Concerning the Agency's Assistance to Mexico in Establishing a Nuclear Power Facility

International Nuclear Information System (INIS)

1974-01-01

The texts of the Supply Agreement between the Agency and the Governments of Mexico and the United States of America, and of the Project Agreement between the Agency and the Government of Mexico concerning the Agency's assistance to that Government in establishing a nuclear power facility, are reproduced herein for the information of all Members. The Agreements entered into force on 12 February 1974, pursuant to Articles VIII and IX respectively.

MENINGKATKAN AKTIVITAS BELAJAR SISWA DENGAN MENGGUNAKAN METODE GROUP INVESTIGATION (GI PADA POKOK BAHASAN PASAR DI KELAS VIII SMP 5 KUDUS

Directory of Open Access Journals (Sweden)

Mutthofiyah Mutthofiyah

2016-03-01

Full Text Available Penelitian ini bertujuan untukmeningkatkan aktivitas belajar siswa dengan menggunakan metode group investigation (GI pada pokok bahasan pasar pada penelitian ini menggunakan penelitian tindakan kelas (PTK. Dalam penelitian ini dirancang menggunakan siklus, masing-masing siklus dengan tahapan perencanaan, pelaksanaan tindakan, observasi dan refleksi. Teknik pengumpulan data pada penelitian ini adalah dokumentasi, observasi dan tes.Hasil penelitian menunjukkan melalui meningkatkan metode group investigation (GI aktivitas siswa SMP 5 Kudus ada peningkatan yang sigifikan, dari siklus I kelas VIII F 15,8 (41,62% meningkat di siklus II menjadi 24,8 (72,9%, sedangkan di kelas VIII G siklus I 18,5 (47,04% meningkat menjadi 26,2 (74,7%; melalui penerapan metode group investigation hasil belajar siswa SMP 5 kudus meningkat sangat signifkan, ketuntasan belajar secara klasikal dari kelas VIII F pra siklus sebesar 17,64% terjadi peningkatan 47% ke siklus I dan meningkat menjadi 82,35% di siklus II. Sedangkan di kelas VII G pra siklus sebesar 22,85% meningkat 54,28% di siklus I dan meningkat menjadi 94,28% di siklus II. Saran yang peneliti berikan adalah sebagai berikut:1Kepada para guru diharapkan dapat menerapkan pembelajaran kooperatif khususnya pembelajaran kooperatif tipe Group Investigation (GI dalam proses pembelajaran ekonomi dan mata pelajaran lainya dan mengembangkannya; 2 Kepada para peneliti selanjutnya diharapkan dapat melakukan penelitian tentang penerapan model pembelajaran yang dapat membangkitkan keaktifan siswa untuk belajar ekonomi. This study aims to improve students' learning activities using group investigation (GI on the subject of markets in class VIII SMP 5 Kudus. In this study is designed to use cycles, with each cycle stages of planning, action, observation and reflection. Data collection techniques in this study is documentation, observation and tests. Results showed through improved methods of group investigation (GI junior 5 high

Isidore of Seville and comici ueteres. Ad Isid., Orig. VIII 7.7

Directory of Open Access Journals (Sweden)

Krzysztof Rzepkowski

2012-12-01

Full Text Available In chapter 7 of book VIII of Etymologies dedicated to Roman poets (De poetis, Isidore draws a dividing line between the so-called ueteres and noui comici. Among ueteres he counts Plautus, Accius, Terentius, although Accius, according to our knowledge, composed only tragedies and can hardly be considered a comic playwright. In this paper I try to prove that all the palaeographic, phonetic, historical, and literary arguments speak in favour of emending in the discussed passage the peculiar «Accius» to the expected «Caecilius» (i.e. Caecilius Statius.

Space nuclear power systems, Part 2

International Nuclear Information System (INIS)

El-Genk, M.S.; Hoover, M.D.

1992-01-01

This volume, number two of three, contains the reviewed and edited papers were being presented at the Ninth Symposium in Albuquerque, New Mexico, 12--16 January 1992. The objective of the symposium, and hence these volumes, is to summarize the state of knowledge in the area of space nuclear power and propulsion and to provide a forum at which the most recent findings and important new developments can be presented and discussed. Topics included is this volume are: reactor and power systems control; thermionic energy conversion; space missions and power needs; key issues in nuclear and propulsion; nuclear thermal propulsion; manufacturing and processing; thermal management; space nuclear safety; and nuclear testing and production facilities

AKTIVITAS FISIK, ASUPAN ENERGI DAN STATUS GIZI WANITA PEMETIK TEH DI PTPN VIII BANDUNG, JAWA BARAT

Directory of Open Access Journals (Sweden)

Venny Agustiani Mahardikawati

2012-03-01

Full Text Available 800x600 Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 Quality of human resources is very important to improve productivity. The worker productivity is correlated with nutritional status and health status. The objective of the research is to analyze physical activity, energy intake, nutritional status, of women workers at Tea Plantation PTPN VIII Bandung, West Java. The cross sectional design was used in this study to elaborate physical activity, nutritional status, and productivity of tea picker’s women. The criteria of study sample were tea picker’s women at cluster area of Malabar tea plantation of PTPN VIII Bandung, having infant and they were willing to be interviewed. The total number of 92 women sample was chosen randomly. Primary data consisted of physical activity recall (2x24 hours, food consumption recall (2x24 hours, anthropometry data (weight and height, and productivity (passage of tea sprout. Secondary data were included data of PT Perkebunan Nusantara VIII Bandung, West Java. The result showed that more than a half of samples having active or moderate physical activity level (PAL. The physical activity level of samples during work day (average PAL=1.87 was higher than holiday (average PAL=1.69 (p2362 kcal and 2134 kcal. The average energy adequacy level during workday and day off according to Schofield and Oxford equation were not significantly different, respectively 97,2% and 103,3%. The majority of samples had normal nutritional status, and 30.4% of the sample was overweight. The energy adequacy level according to Schofield and Oxford equation are related to nutritional status of women workers. Keywords: physical activity, energy expenditure, nutritional status, plantation women

Nuclear physics

International Nuclear Information System (INIS)

Connell, K.A.; Warner, D.D.

1990-01-01

The first volume of the Annual Report for 1989/90 gives an overview of the Nuclear Structure Facility at Daresbury, its development and a selection of highlights of the year's programme. This volume is complementary, presenting brief specialist reports, submitted by the users, describing the progress and results of each individual proposal. The contents reflect the extremely successful year due in good measure to the performance of the tandem accelerator which provided a record number of hours with ''beam on target''. Reports are grouped in four sections: research into nuclear structure with contributions ordered in increasing Z numbers of the nuclei studied; investigations of nuclear reaction mechanisms; nuclear theory; accelerator operations and development plus experimental instrumentation and techniques. The appendix forms a concise summary of the work at the facility for the year. (author)

Nuclear Fuels & Materials Spotlight Volume 5

Energy Technology Data Exchange (ETDEWEB)

Petti, David Andrew [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2016-10-01

As the nation's nuclear energy laboratory, Idaho National Laboratory brings together talented people and specialized nuclear research capability to accomplish our mission. This edition of the Nuclear Fuels and Materials Division Spotlight provides an overview of some of our recent accomplishments in research and capability development. These accomplishments include: • Evaluation and modeling of light water reactor accident tolerant fuel concepts • Status and results of recent TRISO-coated particle fuel irradiations, post-irradiation examinations, high-temperature safety testing to demonstrate the accident performance of this fuel system, and advanced microscopy to improve the understanding of fission product transport in this fuel system. • Improvements in and applications of meso and engineering scale modeling of light water reactor fuel behavior under a range of operating conditions and postulated accidents (e.g., power ramping, loss of coolant accident, and reactivity initiated accidents) using the MARMOT and BISON codes. • Novel measurements of the properties of nuclear (actinide) materials under extreme conditions, (e.g. high pressure, low/high temperatures, high magnetic field) to improve the scientific understanding of these materials. • Modeling reactor pressure vessel behavior using the GRIZZLY code. • New methods using sound to sense temperature inside a reactor core. • Improved experimental capabilities to study the response of fusion reactor materials to a tritium plasma. Throughout Spotlight, you'll find examples of productive partnerships with academia, industry, and government agencies that deliver high-impact outcomes. The work conducted at Idaho National Laboratory helps spur innovation in nuclear energy applications that drive economic growth and energy security. We appreciate your interest in our work here at Idaho National Laboratory, and hope that you find this issue informative.

Optimisation of the link volume for weakest link failure prediction in NBG-18 nuclear graphite

International Nuclear Information System (INIS)

Hindley, Michael P.; Groenwold, Albert A.; Blaine, Deborah C.; Becker, Thorsten H.

2014-01-01

This paper describes the process for approximating the optimal size of a link volume required for weakest link failure calculation in nuclear graphite, with NBG-18 used as an example. As part of the failure methodology, the link volume is defined in terms of two grouping criteria. The first criterion is a factor of the maximum grain size and the second criterion is a function of an equivalent stress limit. A methodology for approximating these grouping criteria is presented. The failure methodology employs finite element analysis (FEA) in order to predict the failure load, at 50% probability of failure. The average experimental failure load, as determined for 26 test geometries, is used to evaluate the accuracy of the weakest link failure calculations. The influence of the two grouping criteria on the failure load prediction is evaluated by defining an error in prediction across all test cases. Mathematical optimisation is used to find the minimum error across a range of test case failure predictions. This minimum error is shown to deliver the most accurate failure prediction across a whole range of components, although some test cases in the range predict conservative failure load. The mathematical optimisation objective function is penalised to account for non-conservative prediction of the failure load for any test case. The optimisation is repeated and a link volume found for conservative failure prediction. The failure prediction for each test case is evaluated, in detail, for the proposed link volumes. Based on the analysis, link design volumes for NBG-18 are recommended for either accurate or conservative failure prediction

Design and Construction Rules for Mechanical components of FBR nuclear islands: RCC-MR. Tome 1, Volume A: generalities

International Nuclear Information System (INIS)

1985-06-01

The French Rules of Mechanical equipments of Fast Neutron nuclear Reactors (RCC-MR) aims at equipments included in a safety classification. The equipments concerned are those of the nuclear boiler and its auxiliaries: tanks, vessels, internal equipments of the reactor, exchangers, pumps, fittings, pipes, and supports. The present edition of the RCC-MR comprises 12 books presented in the present one in the volume A. The chapter RA 3000 defines the documents to be established in application of the RCC-MR rules. The chapter RA 5000 defines the requirements to take into account to establish and carry out quality Assurance programs according to the RCC-MR rules [fr

Molecular characterization of a novel family VIII esterase from burkholderia multivorans UWC10

CSIR Research Space (South Africa)

Rashamuse, KJ

2007-02-01

Full Text Available et al., 1992). Here we report the cloning, purification, and 3D model of a novel family VIII esterase from Burkholderia multivorans UWC10. To our knowledge no report of esterolytic activity from B. multivorans is currently available. METHODOLOGY... stream_source_info Rashamuse1_2007_d.pdf.txt stream_content_type text/plain stream_size 9884 Content-Encoding UTF-8 stream_name Rashamuse1_2007_d.pdf.txt Content-Type text/plain; charset=UTF-8 Molecular Characterization...

Pisanello’s hat. The costume and weapons depicted in Pisanello’s medal for John VIII Palaeologus. A discussion of the saber and related weapons

Directory of Open Access Journals (Sweden)

Alexander, David

2004-12-01

Full Text Available A group of six drawings by the Veronese artist Antonio Pisano depicted the Bizantine Emperor John VIII Paleologus wearing costumes and weapons according to islamic types. This paper studies these objects in relation to other contemporary islamic weapons.

Un grupo de seis dibujos del artista veronés Antonio Pisano representa al emperador bizantino Juan VIII Paleólogo vestido y armado según modelos islámicos. Este trabajo estudia dichos objetos en relación a otras armas islámicas contemporáneas.

Nuclear Law Bulletin No. 95. Volume 2015/1

International Nuclear Information System (INIS)

2015-01-01

The Nuclear Law Bulletin is a unique international publication for both professionals and academics in the field of nuclear law. It provides readers with authoritative and comprehensive information on nuclear law developments. Published free online twice a year in both English and French, it features topical articles written by renowned legal experts, covers legislative developments worldwide and reports on relevant case law, bilateral and international agreements as well as regulatory activities of international organisations. Feature articles in this issue include 'Entry into force of the Convention on Supplementary Compensation for Nuclear Damage: Opening the umbrella'; 'Towards a new international framework for nuclear safety: Developments from Fukushima to Vienna'; 'Nuclear arbitration: Interpreting non-proliferation agreements'. Other chapters deal with case laws, legislative and regulatory activities, intergovernmental organisation activities, and documents and legal texts

Nuclear Law Bulletin No. 96. Volume 2015/2

International Nuclear Information System (INIS)

Reynolds, M.; Thiele, L.; Touitou-Durand, F.; Pelzer, N.; Tafili, V.; Manually, Y.; Adomaityte, U.; Adamczyk, K.; Nowacki, T.; Chiripus, V.; Pistekova, Z.; Skraban, A.; Knopp Pisi, S.; Hoang, V.; Rothschild, T.; Durand, A.; Rivera, S.R.; Salter, I.

2015-01-01

The Nuclear Law Bulletin is a unique international publication for both professionals and academics in the field of nuclear law. It provides readers with authoritative and comprehensive information on nuclear law developments. Published free online twice a year in both English and French, it features topical articles written by renowned legal experts, covers legislative developments worldwide and reports on relevant case law, bilateral and international agreements as well as regulatory activities of international organisations. Feature articles in this issue include 'Treaty implementation applied to conventions on nuclear safety' and 'Crisis, criticism, change: Regulatory reform in the wake of nuclear accidents'. (authors)

Penerapan Model Learning Cycle 5E untuk Meningkatkan Keterampilan Berpikir Kritis Siswa Pada Materi Fluida Statis Kelas VIII

Directory of Open Access Journals (Sweden)

Irhamna Irhamna

2017-08-01

Full Text Available Penerapan model learning cycle 5E telah dilakukan pada siswa kelas VIII dengan materi fluida statis. Penelitian ini bertujuan untuk mendapatkan gambaran mengenai peningkatan keterampilan berpikir kritis siswa setelah diterapkan model learning cycle 5E pada materi fluida statis. Bentuk desain penelitian yang digunakan adalah pre-experimental dengan one group pre-test post-test design. Populasi pada penelitian ini adalah seluruh siswa kelas VIII di SMP Torsina Singkawang. Teknik pengambilan sampel menggunakan sampling purposive yang berjumlah 23 orang. Hasil penelitian menunjukkan bahwa model learning cyle 5E dapat meningkatkan keterampilan berpikir kritis siswa yaitu pada indikator pemecahan masalah dengan skor N-gain sebesar 0,43 dengan kategori sedang, indikator membuat keputusan dengan skor N-gain sebesar 0,42 dengan kategori sedang, indikator penyelidikan percobaan dengan skor N-gain sebesar 0,33 dengan kategori sedang dan indikator menyimpulkan dengan skor N-gain sebesar 0,37 dengan kategori sedang.

The influence of growth temperature and input V/III ratio on the initial nucleation and material properties of InN on GaN by MOCVD

International Nuclear Information System (INIS)

Wang, H; Jiang, D S; Zhu, J J; Zhao, D G; Liu, Z S; Wang, Y T; Zhang, S M; Yang, H

2009-01-01

The effects of growth temperature and V/III ratio on the InN initial nucleation of islands on the GaN (0 0 0 1) surface were investigated. It is found that InN nuclei density increases with decreasing growth temperature between 375 and 525 °C. At lower growth temperatures, InN thin films take the form of small and closely packed islands with diameters of less than 100 nm, whereas at elevated temperatures the InN islands can grow larger and well separated, approaching an equilibrium hexagonal shape due to enhanced surface diffusion of adatoms. At a given growth temperature of 500 °C, a controllable density and size of separated InN islands can be achieved by adjusting the V/III ratio. The larger islands lead to fewer defects when they are coalesced. Comparatively, the electrical properties of the films grown under higher V/III ratio are improved

Insight into resistance mechanism of anaplastic lymphoma kinase to alectinib and JH-VIII-157-02 caused by G1202R solvent front mutation

Directory of Open Access Journals (Sweden)

Wang H

2018-05-01

Full Text Available Han Wang,1–3 Yao Wang,1–3 Wentao Guo,4 Bin Du,1–3 Xiaobing Huang,1–3 Riping Wu,1–3 Baoyu Yang,1–3 Xiaoyan Lin,1–3,5 Yilan Wu6 1Department of Medical Oncology, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of China; 2Stem Cell Research Institute, Fujian Medical University, Fuzhou, People’s Republic of China; 3Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou, People’s Republic of China; 4School of Pharmacy, Wenzhou Medical University, Wenzhou, People’s Republic of China; 5Graduate School of Education, Fujian Medical University, Fuzhou, People’s Republic of China; 6School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, People’s Republic of China Background: Mutated anaplastic lymphoma kinase (ALK drives the development of advanced non-small cell lung cancer (NSCLC. Most reported small-molecule inhibitors targeting the ALK domain do not display good inhibition of the G1202R solvent front mutation. The solvent front mutation was assumed to hinder drug binding. However, a different fact could be uncovered by the simulations reported in this study through a structural analog of alectinib (JH-VIII-157-02, which demonstrated potent effects against the G1202R mutation. Methods: Molecular docking, conventional molecular dynamics (MD simulations, free energy calculations, and umbrella sampling (US simulations were carried out to make clear the principles of the binding preferences of alectinib and JH-VIII-157-02 toward ALKWT and the ALK G1202R (ALKG1202R mutation. Results: JH-VIII-157-02 has similar binding affinities to both ALKWT and ALKG1202R whereas it has has a much lower binding affinity for alectinib to ALKG1202R. Analysis of individual energy terms indicate the major variation involves the van der Waals and entropy terms. Structural analysis reveals that the conformational change of the ATP-binding glycine-rich loop was primarily responsible for the alectinib

Grotrian diagrams for highly ionized cobalt Co VIII through Co XXVII

Energy Technology Data Exchange (ETDEWEB)

Shirai, Toshizo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Sugar, J.; Wiese, W.L.

1997-07-01

Grotrian diagrams are presented to provide graphical overviews for 1,247 spectral lines of highly ionized cobalt, Co VIII through Co XXVII. In the usual diagram display such as that by Bashkin and Stoner (North-Holland, Amsterdam, 1975), the density of transitions is often too high to allow each transition to be drawn separately. Here in our modified diagrams, the transitions are also represented by lines connecting the upper and lower energy levels, but the lower energy levels are extended and repeated for successive configurations as needed. As a sequence, dense packing is avoided and all lines in a multiplet can be accommodated. (author)

Comercio Internacional mediterráneo en el siglo VIII a.C.

Directory of Open Access Journals (Sweden)

Paloma Cabrera Bonet

2018-01-01

Full Text Available The VIII century B.C. saw, for the first time after the breakdown of the system in the Late Bronze Age, the revival of a true intemational trade at a growing scale, especíally protagonized by Phoenicians and Greeks. In this article we analyze sorne aspects of this phenomenon, from the Aegean to the Far West, which made possíble, through a vaste network of trading routes, a large multinational ínteractíon. We understand the international trade as a key factor in the proccess of economic, social and political changes of the Mediterranean areas submerged in this complex "world-system".

Proceedings of the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics NURETH-7. Volume 3, Sessions 12-16

Energy Technology Data Exchange (ETDEWEB)

Block, R.C.; Feiner, F. [comps.] [American Nuclear Society, La Grange Park, IL (United States)

1995-09-01

This document, Volume 3, includes papers presented at the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics (NURETH-7) September 10--15, 1995 at Saratoga Springs, N.Y. The following subjects are discussed: Progress in analytical and experimental work on the fundamentals of nuclear thermal-hydraulics, the development of advanced mathematical and numerical methods, ad the application of advancements in the field in the development of novel reactor concepts. Also combined issues of thermal-hydraulics and reactor/power-plant safety, core neutronics and/or radiation. Selected abstracts have been indexed separately for inclusion in the Energy Science and Technology Database.

Proceedings of the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics NURETH-7. Volume 1, Sessions 1-5

International Nuclear Information System (INIS)

Block, R.C.; Feiner, F.

1995-09-01

This document, Volume 1, includes papers presented at the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics (NURETH-7) September 10--15, 1995 at Saratoga Springs, N.Y. The following subjects are discussed: Progress in analytical and experimental work on the fundamentals of nuclear thermal-hydraulics, the development of advanced mathematical and numerical methods, and the application of advancements in the field in the development of novel reactor concepts. Also combined issues of thermal-hydraulics and reactor/power-plant safety, core neutronics and/or radiation. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database

Proceedings of the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics NURETH-7. Volume 2, Sessions 6-11

Energy Technology Data Exchange (ETDEWEB)

Block, R.C.; Feiner, F. [comps.] [American Nuclear Society, La Grange Park, IL (United States)

1995-09-01

This document, Volume 2, includes papers presented at the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics (NURETH-7) September 10--15, 1995 at Saratoga Springs, N.Y. The following subjects are discussed: Progress in analytical and experimental work on the fundamentals of nuclear thermal-hydraulics, the development of advanced mathematical and numerical methods, and the application of advancements in the field in the development of novel reactor concepts. Also combined issues of thermal-hydraulics and reactor/power-plant safety, core neutronics and/or radiation. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

Proceedings of the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics NURETH-7. Volume 1, Sessions 1-5

Energy Technology Data Exchange (ETDEWEB)

Block, R.C.; Feiner, F. [comps.] [American Nuclear Society, La Grange Park, IL (United States)

1995-09-01

This document, Volume 1, includes papers presented at the 7th International Meeting on Nuclear Reactor Thermal-Hydraulics (NURETH-7) September 10--15, 1995 at Saratoga Springs, N.Y. The following subjects are discussed: Progress in analytical and experimental work on the fundamentals of nuclear thermal-hydraulics, the development of advanced mathematical and numerical methods, and the application of advancements in the field in the development of novel reactor concepts. Also combined issues of thermal-hydraulics and reactor/power-plant safety, core neutronics and/or radiation. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

Measurement of volumic activities of radon in air in houses and in working rooms with solid state nuclear track detectors

International Nuclear Information System (INIS)

Hakam, O.K.

1993-01-01

In this work, a new method of measuring volumic activity of radon has been developed. This method is based on using solid state nuclear track detectors LR-115 type II. It has been applied to measurement of volumic activities of radon in air in houses and in working rooms in different regions of Morocco. These measurements, carried out for the first time in the country, allowed to estimate the dose equivalents of radon received by the population of the studied regions. 59 refs., 38 figs., 38 tabs. (F.M.)

Nuclear Law Bulletin No. 98. Volume 2016/2

International Nuclear Information System (INIS)

Wetherall, Anthony C.; Soedersten, Anna; Berger, Marjorie; Paez, M.R.; Touitou-Durand, F.; Pelzer, N.; Adomaityte, U.; Majerus, P.; Nowacki, T.; Pospisil, M.; Skraban, A.; Noelliste, N.E.; Popov, A.; Drillat, C.; Reynaers Kini, E.

2016-01-01

The Nuclear Law Bulletin is a unique international publication for both professionals and academics in the field of nuclear law. It provides readers with authoritative and comprehensive information on nuclear law developments. Published free online twice a year in both English and French, it features topical articles written by renowned legal experts, covers legislative developments worldwide and reports on relevant case law, bilateral and international agreements as well as regulatory activities of international organisations. Feature articles in this issue include 'Strengthening the international legal framework for nuclear security: Better sooner rather than later'; 'Brexit, Euratom and nuclear proliferation'; and 'McMunn et al. v Babcock and Wilcox Power Generation Group, Inc., et al.: The long road to dismissal'

Nuclear Law Bulletin No. 99. Volume 2017/1

International Nuclear Information System (INIS)

Burns, Stephen G.; Lamm, Vanda; Pelzer, Norbert; Popov, A.; ); Chirtes, A.P.; ); Raetzke, C.; Chennoufi, F.; Beyens, M.; Vandeputte, G.; Saric, J.; Touitou-Durand, F.; Pelzer, N.; Adomaityte, U.; Pavlovic, P.; Skraban, A.; Carroll, S.; Averbach, A.; Brown, O.; Irving, I.; Joyner, D.

2017-01-01

The Nuclear Law Bulletin is a unique international publication for both professionals and academics in the field of nuclear law. It provides readers with authoritative and comprehensive information on nuclear law developments. Published free online twice a year in both English and French, it features topical articles written by renowned legal experts, covers legislative developments worldwide and reports on relevant case law, bilateral and international agreements as well as regulatory activities of international organisations. Feature articles in this issue include: 'Reformed and reforming: Adapting the licensing process to meet new challenges'; 'Reflections on the development of international nuclear law'; and 'Facing the challenge of nuclear mass tort processing'

Analysis of inversions in the factor VIII gene in Spanish hemophilia A patients and families

Energy Technology Data Exchange (ETDEWEB)

Domenech, M.; Tizzano, E.; Baiget, M. [Hospital de Sant Pau, Barcelona (Spain); Altisent, C. [Hospital Vall d`Hebron, Barcelona (Spain)

1994-09-01

Intron 22 is the largest intron of the factor VIII gene and contains a CpG island from which two additional transcripts originate. One of these transcripts corresponds to the F8A gene which have telomeric extragenic copies in the X chromosome. An inversion involving homologous recombination between the intragenic and the distal or proximal copies of the F8A gene has been recently described as a common cause of severe hemophilia A (HA). We analyzed intron 22 rearrangements in 195 HA patients (123 familial and 72 sporadic cases). According to factor VIII levels, our sample was classified as severe in 114 cases, moderate in 29 cases and mild in 52 cases. An intron 22 (F8A) probe was hybridized to Southern blots of BcII digested DNA obtained from peripheral blood. A clear pattern of altered bands identifies distal or proximal inversions. We detected an abnormal pattern identifying an inversion in 49 (25%) of the analyzed cases. 43% of severe HA patients (49 cases) showed an inversion. As expected, no inversion was found in the moderate and mild group of patients. We found a high proportion (78%) of the distal rearrangement. From 49 identified inversions, 33 were found in familial cases (27%), while the remaining 15 were detected in sporadic patients (22%) in support that this mutational event occurs with a similar frequency in familial or sporadic cases. In addition, we detected a significant tendency of distal inversion to occur more frequently in familial cases than in sporadic cases. Inhibitor development to factor VIII was documented in approximately 1/3 of the patients with inversion. The identification of such a frequent molecular event in severe hemophilia A patients has been applied in our families to carrier and prenatal diagnosis, to determine the origin of the mutation in the sporadic cases and to detect the presence of germinal mosaicism.

Nuclear Data Newsletter, No. 64, January 2018

International Nuclear Information System (INIS)

2018-01-01

This Newsletter contains, as usual, the complete overview of meetings. Notable large ones, in terms of number of participants, were Research Coordination Meetings on Photon Strength Functions and Photonuclear Data, Primary Radiation Damage Cross Sections, and a Technical Meeting on Data Processing. Just before the end of 2017, we held a Technical Meeting on the International Nuclear Data Evaluation Network, which is one of the follow-ups of the CIELO initiative that was hosted by the NEA in past years. This nuclear data evaluation network will focus on the next list of high-priority nuclides which need to be evaluated with high precision. The website of the meeting is available at https://wwwnds. iaea.org/index-meeting-crp/TM_IAEACIELO/. As a related topic, this is also the time and place to congratulate the nuclear data communities in the US and the OECD on the release of their ENDF/B-VIII and JEFF-3.3 libraries, respectively. Our Section has monitored these releases closely, and contributed evaluations. Therefore, it is good to see that a new level of international nuclear reaction data has been reached. By the way, as mentioned in this Newsletter a third data library, TENDL-2017, was also released last month

Development of Integrated Natural Science Teaching Materials Webbed Type with Applying Discourse Analysis on Students Grade VIII in Physics Class

Science.gov (United States)

Sukariasih, Luh

2017-05-01

This study aims to produce teaching materials integrated natural science (IPA) webbed type of handout types are eligible for use in integrated science teaching. This type of research IS a kind of research and development / Research and Development (R & D) with reference to the 4D development model that is (define, design, develop, and disseminate). Data analysis techniques used to process data from the results of the assessment by the validator expert, and the results of the assessment by teachers and learners while testing is limited (12 students of class VIII SMPN 10 Kendari) using quantitative descriptive data analysis techniques disclosed in the distribution of scores on the scale of five categories grading scale that has been determined. The results of due diligence material gain votes validator material in the category of “very good” and “good”, of the data generated in the feasibility test presentation obtained the category of “good” and “excellent”, from the data generated in the feasibility of graphic test obtained the category of “very good “and” good “, as well as of the data generated in the test the feasibility of using words and language obtained the category of“very good “and” good “, so with qualifications gained the teaching materials IPA integrated type webbed by applying discourse analysis on the theme of energy and food for Junior High School (SMP) grade VIII suitable as teaching materials. In limited testing, data generated in response to a science teacher at SMPN 10 Kendari to product instructional materials as “excellent”, and from the data generated while testing is limited by the 12 students of class VIII SMPN 10 Kendari are more students who score indicates category “very good”, so that the qualification obtained by the natural science (IPA) teaching material integrated type webbed by applying discourse analysis on the theme of energy and food for SMP / class VIII fit for use as teaching material.

Storage - Nuclear wastes are overflowing

International Nuclear Information System (INIS)

Dupin, Ludovic

2016-01-01

This article highlights that the dismantling of French nuclear installations will generate huge volumes of radioactive wastes and that France may lack space to store them. The Cigeo project (underground storage) only concerns 0.2 per cent of the nuclear waste volume produced by France in 50 years. If storage solutions exist for less active wastes, they will soon be insufficient, notably because of the quantity of wastes produced by the dismantling of existing reactors and fuel processing plants. Different assessments of these volumes are evoked. In order to store them, the ANDRA made a second call for innovating projects which would enable a reduction of this volume by 20 to 30 per cent. The article also evokes projects selected after the first call for projects. They mainly focus on nuclear waste characterization which will result in a finer management of wastes regarding their storage destination. Cost issues and the opposition of anti-nuclear NGOs are still obstacles to the development of new sites

Nuclear Law Bulletin No. 97. Volume 2016/1

International Nuclear Information System (INIS)

Fischer, D.; Saric, J.; Touitou-Durand, F.; Mannully, Y.; Parle, M.; Adomaityte, U.; Majerus, P.; Adamczyk, K.; Nowacki, T.; Pavlovic, P.; Dovale Hernandez, I.; Ammon, B.; Popov, A.; Drillat, C.; Reynaers Kini, E.

2016-01-01

The Nuclear Law Bulletin is a unique international publication for both professionals and academics in the field of nuclear law. It provides readers with authoritative and comprehensive information on nuclear law developments. Published free online twice a year in both English and French, it features topical articles written by renowned legal experts, covers legislative developments worldwide and reports on relevant case law, bilateral and international agreements as well as regulatory activities of international organisations. Feature articles in this issue include 'Nuclear third party liability in Germany' and 'Towards nuclear disarmament: State of affairs in the international legal framework'. Other chapters deal with case laws, legislative and regulatory activities, intergovernmental organisation activities, and documents and legal texts

Advances in nuclear science and technology

CERN Document Server

Henley, Ernest J

1962-01-01

Advances in Nuclear Science and Technology, Volume 1 provides an authoritative, complete, coherent, and critical review of the nuclear industry. This book covers a variety of topics, including nuclear power stations, graft polymerization, diffusion in uranium alloys, and conventional power plants.Organized into seven chapters, this volume begins with an overview of the three stages of the operation of a power plant, either nuclear or conventionally fueled. This text then examines the major problems that face the successful development of commercial nuclear power plants. Other chapters consider

Nuclear reaction data and nuclear reactors

Energy Technology Data Exchange (ETDEWEB)

Paver, N [University of Trieste (Italy); Herman, M [International Atomic Energy Agency, Vienna (Austria); Gandini, A [ENEA, Rome (Italy)

2001-12-15

These two volumes contain the lecture notes of the workshop 'Nuclear Reaction Data and Nuclear Reactors: Physics, Design and Safety', which was held at the Abdus Salam ICTP in the Spring of 2000. The workshop consisted of five weeks of lecture courses followed by practical computer exercises on nuclear data treatment and design of nuclear power systems. The spectrum of topics is wide enough to timely cover the state-of-the-art and the perspectives of this broad field. The first two weeks were devoted to nuclear reaction models and nuclear data evaluation. Nuclear data processing for applications to reactor calculations was the subject of the third week. On the last two weeks reactor physics and on-going projects in nuclear power generation, waste disposal and safety were presented.

Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models

OpenAIRE

Siner, Joshua I.; Samelson-Jones, Benjamin J.; Crudele, Julie M.; French, Robert A.; Lee, Benjamin J.; Zhou, Shanzhen; Merricks, Elizabeth; Raymer, Robin; Nichols, Timothy C.; Camire, Rodney M.; Arruda, Valder R.

2016-01-01

Processing by the proprotein convertase furin is believed to be critical for the biological activity of multiple proteins involved in hemostasis, including coagulation factor VIII (FVIII). This belief prompted the retention of the furin recognition motif (amino acids 1645–1648) in the design of B-domain–deleted FVIII (FVIII-BDD) products in current clinical use and in the drug development pipeline, as well as in experimental FVIII gene therapy strategies. Here, we report that processing by fu...

PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE STAD BERBANTUAN PEMETAAN PIKIRAN (MIND MAPPING TERHADAP KEMAMPUAN MENULIS TEKS BERITA SISWA KELAS VIII SMP NEGERI 1 PANTI

Directory of Open Access Journals (Sweden)

Ricci Gemarni Tatalia, M.Pd

2017-05-01

Full Text Available This study was generated from the problem of students’ ability in writing news texts ini class VIII, SMPN 1 Panti. Some of the problem were (1 lack of the students’ response towards news writing teaching and learning process, (2 lack of teacher’s creativity in designing interesting news sriting learning model, (3 no appropriate creative techniques applied by the teacher which could train the students to develop their skill in writing news texts and (4 lack of the students’ motivation in participating in teaching and learning process because of their lack of understanding in the elements of news. Thus, this study was aimed at escribing the effect of the students’ ability ini writing news texts in class VIII SMP N 1 Panti. This was a quantitative research with factorial 2x2 experimental design. The population was the students in class VIII SMPN 1 Panti. Sampling technique was done by using random sampling and the data was collected through test. The result of the study revealed that cooperative learning model with STAD mind mapping type affected the students’ ability in writing news texts

The Fukushima Daiichi Accident. Technical Volume 4/5. Radiological Consequences. Annexes

International Nuclear Information System (INIS)

2015-08-01

The Fukushima Daiichi Accident consists of a Report by the IAEA Director General and five technical volumes. It is the result of an extensive international collaborative effort involving five working groups with about 180 experts from 42 Member States with and without nuclear power programmes and several international bodies. It provides a description of the accident and its causes, evolution and consequences, based on the evaluation of data and information from a large number of sources available at the time of writing. The Fukushima Daiichi Accident will be of use to national authorities, international organizations, nuclear regulatory bodies, nuclear power plant operating organizations, designers of nuclear facilities and other experts in matters relating to nuclear power, as well as the wider public. The set contains six printed parts and five supplementary CD-ROMs. Contents: Report by the Director General; Technical Volume 1/5, Description and Context of the Accident; Technical Volume 2/5, Safety Assessment; Technical Volume 3/5, Emergency Preparedness and Response; Technical Volume 4/5, Radiological Consequences; Technical Volume 5/5, Post-accident Recovery; Annexes. The Report by the Director General is available separately in Arabic, Chinese, English, French, Russian, Spanish and Japanese

HTGR accident initiation and progression analysis status report. Volume VIII. Responses to comments on AIPA status report

Energy Technology Data Exchange (ETDEWEB)

Raabe, P.H.

1977-01-01

The first seven volumes of the report series provide formal documentation of the status of the ERDA-sponsored Accident Initiation and Progression Analysis (AIPA) study as of the end of FY75. That portion of the report was given broad distribution to government agencies, industrial organizations, and academic institutions. Comments on the Status Report have been actively solicited from these and other organizations. The volume presented (the eighth in the AIPA Status Report) documents all of the formal written comments that have been received as of September 30, 1976, together with the responses to those comments. The comments as presented are direct quotations from the manuscripts as submitted by the reviewers; none have been paraphrased. The comments are presented in the same order as submitted by the reviewers and are generally addressed individually.

HTGR accident initiation and progression analysis status report. Volume VIII. Responses to comments on AIPA status report

International Nuclear Information System (INIS)

Raabe, P.H.

1977-01-01

The first seven volumes of the report series provide formal documentation of the status of the ERDA-sponsored Accident Initiation and Progression Analysis (AIPA) study as of the end of FY75. That portion of the report was given broad distribution to government agencies, industrial organizations, and academic institutions. Comments on the Status Report have been actively solicited from these and other organizations. The volume presented (the eighth in the AIPA Status Report) documents all of the formal written comments that have been received as of September 30, 1976, together with the responses to those comments. The comments as presented are direct quotations from the manuscripts as submitted by the reviewers; none have been paraphrased. The comments are presented in the same order as submitted by the reviewers and are generally addressed individually

User's guide for PRISIM (Plant Risk Status Information Management System) Arkansas Nuclear One--Unit 1: Volume 2, Program for regulators

Energy Technology Data Exchange (ETDEWEB)

Campbell, D.J.; Guthrie, V.H.; Kirchner, J.R.; Kirkman, J.Q.; Paula, H.M.; Ellison, B.C.; Dycus, F.M.; Farquharson, J.A.; Flanagan, G.F.

1988-03-01

This user's guide is a two-volume document designed to teach NRC inspectors and NRC regulators how to access probabilistic risk assessment information from the two Plant Risk Status Information Management System (PRISIM) programs developed for Arkansas Nuclear One--Unit One (ANA-1). This document, Volume 2, describes how the PRA information available in Version 2.0 of PRISIM is useful as an evaluation tool for regulatory activities. Using PRISIM is useful as an evaluation tool for regulatory activities. Using PRISIM, regulators can both access PRA information and modify the information to assess the impact these changes may have on plant safety. Each volume is a stand-alone document.

An immunoradiometric assay for procoagulant factor VIII antigen: results in haemophilia, von Willebrand's disease and fetal plasma and serum

International Nuclear Information System (INIS)

Peake, I.R.; Bloom, A.L.; Giddings, J.C.; Ludlam, C.A.

1979-01-01

An immunoradiometric assay (IRMA) has been developed based on the inhibitor which arose in a polytransfused severe haemophiliac. The two-site IRMA measured antigens closely associated with the procoagulant parts of the factor VIII complex, which are termed FVIIIC antigens or FVIIICAG. FVIIICAG was present in normal plasma and also, at a slightly lower concentration, in normal serum. In 37 patients with haemophilia A, 36 had FVIIICAG levels of less than 10% of the normal plasma pool. In patients with von Willebrand's disease the levels of FVIIIC and FVIIICAG were in good agreement, both before and after treatment with cryoprecipitate or DDAVP. FVIIICAG was relatively stable in plasma at 37 0 C and could also be detected in cord and fetal serum. The assay is of potential value for detecting reduced levels of factor VIII, for carrier detection and for the prenatal diagnosis of haemophilia. (author)

Estudo da articulação temporomandibular em camundongos deficientes de fator VIII

OpenAIRE

Patricia do Socorro Queiroz Feio

2010-01-01

Resumo: A hemofilia é uma doença hemorrágica hereditária ligada ao cromossomo X, decorrente da ausência ou da baixa quantidade no plasma dos fatores de coagulação Fator VIII (hemofilia A) ou do Fator IX (hemofilia B). Clinicamente, a hemofilia se caracteriza por episódios recorrentes de sangramentos profundos, que podem ocorrer espontaneamente ou em decorrência de traumatismos. O sistema músculo-esquelético é freqüentemente afetado pelos eventos hemorrágicos nos pacientes portadores de hemofi...

Proceedings of the 29th annual conference of the Canadian Nuclear Association and 10th annual conference of the Canadian Nuclear Society. V. 1-3

Energy Technology Data Exchange (ETDEWEB)

Harvey, M; Fehrenbach, P J [eds.

1990-12-31

The symposium was designed to highlight how the technical information for nuclear energy came to Canada, the effect this information had in Canada in the fields of Physics, Chemistry, Medicine and Nuclear Power. Volume 1 is the combined proceedings of the Canadian Nuclear Association twenty-ninth annual conference and the Canadian Nuclear Society tenth annual conference. Volume 2 is the proceedings of the Canadian Nuclear Association twenty-ninth annual conference, and volume 3 is the proceedings of the Canadian Nuclear Society tenth annual conference.

Proceedings of the 29th annual conference of the Canadian Nuclear Association and 10th annual conference of the Canadian Nuclear Society. V. 1-3

International Nuclear Information System (INIS)

Harvey, M.; Fehrenbach, P.J.

1989-01-01

The symposium was designed to highlight how the technical information for nuclear energy came to Canada, the effect this information had in Canada in the fields of Physics, Chemistry, Medicine and Nuclear Power. Volume 1 is the combined proceedings of the Canadian Nuclear Association twenty-ninth annual conference and the Canadian Nuclear Society tenth annual conference. Volume 2 is the proceedings of the Canadian Nuclear Association twenty-ninth annual conference, and volume 3 is the proceedings of the Canadian Nuclear Society tenth annual conference

The treaty for the prohibition of nuclear weapons in Latin America and the Caribbean

International Nuclear Information System (INIS)

1994-01-01

The text of the statement, made by Ambassador Carlos Portales Cifuentes, Director General for Foreign Policy of the Ministry of External Relations of Chile, during the VIII. Special Session of the General Conference of the Agency for the Prohibition of Nuclear Weapons in Latin America and the Caribbean (OPANAL) on the occasion of Chile's becoming a Contracting Party to the Tlatelolco Treaty, is being circulated for the information of all Member States of the Agency at the request of the Alternate to the Resident Representative of Chile

EFFECT OF INFORMATION SERVICES USING THE MEDIA FILM TO SELF-CONFIDENCE STUDENT OF CLASS VIII SMP NEGERI 8 METRO

Directory of Open Access Journals (Sweden)

MUDAIM MUDAIM

2015-06-01

Full Text Available Abstract: Pessimism and attitudes that consider themselves weak and does not have the ability when facing a problem will make individual impediment in the task of development. Problems confidence that underlies the research are: a Students are less confident in the ability it has, b Students feel pessimistic when faced with an issue, c Student perception subjectively, d Students still do not do the work independently, and e negative minded students with a state-owned. The problems of this study are whether there is an influence of information services using the medium of film to the confidence of eighth-grade students of SMP Negeri 8 Metro. The purpose of this study was to determine whether there is an influence of information services using the medium of film to the self-confidence of students in class VIII SMP Negeri 8 Metro. Subject participant is graders VIII-E total 30 students. Data were collected by questionnaire self-confidence and analyzed the data used is the t-test. The results of this study, shown by the difference in change scores of confidence from the pre-test and post-test of 17.1. Testing the hypothesis obtained calculation results thitung6,036> table = 1.699. The conclusion is that the information services implemented using the film medium can be a positive influence on self-esteem, especially students of class VIII. The advice given is to use the medium of film should be done intensively and more creative by BK teachers in giving information service. Keywords: Confidence, Service Information Using Media Film.

Technical support for GEIS: radioactive waste isolation in geologic formations. Volume 22. Nuclear considerations for repository design

International Nuclear Information System (INIS)

1978-04-01

This volume, Y/OWI/TM-36/22, ''Nuclear Considerations for Repository Design,'' is one of a 23-volume series, ''Technical Support for GEIS: Radioactive Waste Isolation in Geologic Formations,'' Y/OWI/TM-36, which supplements the ''Contribution to Draft Generic Environmental Impact Statement on Commercial Waste Management: Radioactive Waste Isolation in Geologic Formations,'' Y/OWI/TM-44. The series provides a more complete technical basis for the preconceptual designs, resource requirements, and environmental source terms associated with isolating commercial LWR wastes in underground repositories in salt, granite, shale and basalt. Wastes are considered from three fuel cycles: uranium and plutonium recycling, no recycling of spent fuel and uranium-only recycling. Included in this volume are baseline design considerations such as characteristics of canisters, drums, casks, overpacks, and shipping containers; maximum allowable and actual decay-heat levels; and canister radiation levels. Other topics include safeguard and protection considerations; occupational radiation exposure including ALARA programs; shielding of canisters, transporters and forklift trucks; monitoring considerations; mine water treatment; canister integrity; and criticality calculations

75 FR 36426 - Legislative Changes to Nursing Student Loan Program Authorized Under Title VIII of the Public...

Science.gov (United States)

2010-06-25

... Changes to Nursing Student Loan Program Authorized Under Title VIII of the Public Health Service Act....) 111-148. Section 5202 of the ACA changes the Nursing Student Loan (NSL) program by: (1) Increasing the... degree in nursing. Below are details on how the ACA changes Sections 836(a), 836(b)(1), and 836(b)(3) of...

Advanced training course on state systems of accounting for and control of nuclear materials. Volume I. Program for technical assistance to IAEA safeguards

International Nuclear Information System (INIS)

Sorenson, R.J.; Schneider, R.A.

1979-01-01

Purpose of the course was to provide practical training in the implementation and operation of a national system of accounting for and control of nuclear materials in a bulk processing facility, in the context of international safeguards. This course extends the training received in the basic course on State Systems of Accounting for and Control of Nuclear Materials to a practical, illustrative example utilizing the Exxon Nuclear low enriched uranium fabrication plant. Volume I of this manual contains the text of the presentations following the outline of the syllabus. Sample problems and answers are also included, along with some visual aids

In situ leaching of a nuclear rubblized copper ore body. Volume II

International Nuclear Information System (INIS)

1975-06-01

This volume contains detailed descriptions of technical and economical evaluations undertaken for the feasibility study. A summary of these results can be found in Vol. 1 along with the conclusions derived from the feasibility study and the recommendations tendered for future work. The sections of this study are presented in process order, and each section is complete in itself. The form of the presentation, hopefully, is logical and in a manner suitable for design purposes. As a further aid, each section has its own table of contents. The sections presented include method of attack, reference case, description of concept, nuclear rubblization, blasting plan, underground plumbing, fluid circulation, leaching technology, wellhead plant and pipeline, process plant, material and heat balance, hydrology, radioactivity, seismic, economics, sensitivity analysis, guide for environmental studies, exploration, and recommended experimental program. (U.S.)

User's guide for PRISM (Plant Risk Status Information Management System) Arkansas Nuclear One-Unit 1: Volume 1, Program for inspectors

Energy Technology Data Exchange (ETDEWEB)

Campbell, D.J.; Guthrie, V.H.; Kirchner, J.R.; Kirkman, J.Q.; Paula, H.M.; Ellison, B.C.; Dycus, F.M.; Farquharson, J.A.; Flanagan, G.F.

1988-03-01

This user's guide is a two-volume document designed to teach NRC inspectors and NRC regulators how to access probabilistic risk assessment information from the two Plant Risk Status Information Management System (PRISIM) programs developed for Arkansas Nuclear One -- Unit One (ANO-1). This document, Volume 1, describes how the PRA information available in Version 1.0 of PRISIM is useful for planning inspections. Using PRISIM, inspectors can quickly access PRA information and use that information to update risk analysis results, reflecting a plant's status at any particular time. Both volumes are stand-alone documents, and each volume presents several sample computer sessions designed to lead the user through a variety of PRISIM applications used to obtain PRA-related information for monitoring and controlling plant risk.

PENINGKATAN AKTIVITAS DAN HASIL BELAJAR POKOK BAHASAN PASAR DENGAN METODE RESITASI PADA SISWA KELAS VIII SMP NEGERI 24 SEMARANG TAHUN AJARAN 2013/2014

Directory of Open Access Journals (Sweden)

Diinul Qoyyimah

2013-11-01

Full Text Available Aktivitas siswa kelas VIII pada mata pelajaran ekonomi SMP Negeri 24 Semarang pada pokok bahasan pasar masih rendah sehingga berdampak pada hasil belajar siswa yang masih dibawah KKM. Salah satu penyebabnya karena guru masih menerapkan metode belajar yang sama dalam waktu yang lama sehingga mengakibatkan rendahnya perolehan hasil belajar. Melalui penerapan metode ceramah bervariasi dan resitasi diharapkan siswa dapat belajar dengan santai dan senang dalam mengikuti proses pembelajaran. Penelitian ini bertujuan untuk mengetahui penerapan metode resitasi, dapat meningkatkan aktivitas dan hasil belajar siswa. Metode penelitian menggunakan penelitian tindakan kelas. Prosedur penelitian dilakukan dimulai dengan perencanaan, pelaksanaan, observasi dan refleksi. Metode pengumpulan data dengan dokumentasi dan tes. Hasil penelitian menyatakan bahwa ada peningkatan aktivitas siswa dan hasil belajar siswa materi pasar pada kelas VIII SMP Negeri 24 Semarang tahun 2013/2014. The students’ activity in VIII class of economic subject in SMP Negeri 24 Semarang in the subject matter of market topic is still low so it has the impact on the students’ learning outcome which is still under KKM requirements. One of the causes is because the teachers are still apply the same learning method in a long time so it resulted in low learning outcomes acquisition.through the application of various conventional methods and recitation are expected that students can learn easily and pleasure in participating of learning process. This study aims to determine the application of recitation method which can improve the activity and students’ learning outcomes. The research method using classroom action research. The research procedure begins with planning, implementation, observation and reflection. Methods of data collection carried out by documentation and test. The result of research states that there is an increasing activity and students’ learning outcomes in the

Design local exhaust ventilation on sieve machine at PT.Perkebunan Nusantara VIII Ciater using design for assembly (DFA) approach with Boothroyd and Dewhurst method

Science.gov (United States)

Khalqihi, K. I.; Rahayu, M.; Rendra, M.

2017-12-01

PT Perkebunan Nusantara VIII Ciater is a company produced black tea orthodox more or less 4 tons every day. At the production section, PT Perkebunan Nusantara VIII will use local exhaust ventilation specially at sortation area on sieve machine. To maintain the quality of the black tea orthodox, all machine must be scheduled for maintenance every once a month and takes time 2 hours in workhours, with additional local exhaust ventilation, it will increase time for maintenance process, if maintenance takes time more than 2 hours it will caused production process delayed. To support maintenance process in PT Perkebunan Nusantara VIII Ciater, designing local exhaust ventilation using design for assembly approach with Boothroyd and Dewhurst method, design for assembly approach is choosen to simplify maintenance process which required assembly process. There are 2 LEV designs for this research. Design 1 with 94 components, assembly time 647.88 seconds and assembly efficiency level 23.62%. Design 2 with 82 components, assembly time 567.84 seconds and assembly efficiency level 24.83%. Design 2 is choosen for this research based on DFA goals, minimum total part that use, optimization assembly time, and assembly efficiency level.

Intenational conference on high-energy physics. Volume 2. Sessions IV to VIII. [Geneva, June 27-July 4, 1979

Energy Technology Data Exchange (ETDEWEB)

1980-02-01

Volume 2 of the conference proceedings contains sessions on hadron physics, charged-lepton physics, the p-p-bar collider at CERN, future European accelerator possibilities, parallel discussion sessions (on high-energy) hadron-induced reactions, deep inelastic phenomena, hadron spectroscopy, weak ineractions and gauge theories, and quark confinement), and a closing session on gauge appreciation of developments in particle physics. A list of participants is also included. Three of the papers in this volume have already been cited in ERA, and can be found as reference to the entry CONF-790642-- in the Report Number Index. The remaining 36 will be processed as they are received on the Atomindex tape. (RWR)

Nuclear Safety: Volume 29, No. 3: Technical progress review

Energy Technology Data Exchange (ETDEWEB)

Silver, E G [ed.

1988-07-01

Nuclear Safety is a review journal that covers significant development in the field of nuclear safety. Its scope included the analysis and control of hazards associated with nuclear energy, operations involving fissionable materials and the products of nuclear fission and their effects on the environment. Primary emphasis is on safety in reactor design, construction, and operation; however, the safety aspects of the entire fuel cycle, including fuel fabrication, spent-fuel processing, nuclear waste disposal, handling of radioisotopes, and environmental effects of these operations, are also treated. Individual papers have been cataloged separately.

Use of volume-rendered images in registration of nuclear medicine studies

International Nuclear Information System (INIS)

Wallis, J.W.; Miller, T.R.; Hsu, S.S.

1995-01-01

A simple operator-guided alignment technique based on volume-rendered images was developed to register tomographic nuclear medicine studies. For each of 2 three-dimensional data sets to be registered, volume-rendered images were generated in 3 orthogonal projections (x,y,z) using the method of maximum-activity projection. Registration was achieved as follows: (a) One of the rendering orientations (e.g. x) was chosen for manipulation; (b) The two dimensional rendering was translated and rotated under operator control to achieve the best alignment as determined by visual assessment; (c) This rotation and translation was then applied to the underlying three-dimensional data set, with updating of the rendered images in each of the orthogonal projections; (d) Another orientation was chosen, and the process repeated. Since manipulation was performed on the small two-dimensional rendered image, feedback was instantaneous. To aid in the visual alignment, difference images and flicker images (toggling between the two data sets) were displayed. Accuracy was assessed by analysis of separate clinical data sets acquired without patient movement. After arbitrary rotation and translation of one of the two data sets, the 2 data sets were registered. Mean registration error was 0.36 pixels, corresponding to a 2.44 mm registration error. Thus, accurate registration can be achieved in under 10 minutes using this simple technique. The accuracy of registration was assessed with use of duplicate SPECT studies originating from separate reconstructions of the data from each of the detectors of a triple-head gamma camera

Report of the US Nuclear Regulatory Commission Piping Review Committee. Volume 5. Summary - Piping Review Committee conclusions and recommendations

International Nuclear Information System (INIS)

1985-04-01

This document summarizes a comprehensive review of NRC requirements for Nuclear Piping by the US NRC Piping Review Committee. Four topical areas, addressed in greater detail in Volumes 1 through 4 of this report, are included: (1) Stress Corrosion Cracking in Piping of Boiling Water Reactor Plants; (2) Evaluation of Seismic Design; (3) Evaluation of Potential for Pipe Breaks; and (4) Evaluation of Other Dynamic Loads and Load Combinations. This volume summarizes the major issues, reviews the interfaces, and presents the Committee's conclusions and recommendations for updating NRC requirements on these issues. This report also suggests research or other work that may be required to respond to issues not amenable to resolution at this time

Nuclear Regulatory Commission issuances. Volume 40, Number 5

International Nuclear Information System (INIS)

1994-11-01

This book contains issuances of the Atomic Safety and Licensing Boards for November 1994. The issuances include Cameo Diagnostic Centre, Inc. byproduct material license; Georgia Power Company license amendment, transfer to Southern Nuclear for Vogtle Electric Generating Plant, units 1 and 2; Indiana Regional Cancer Center, order modifying and suspending byproduct material license; Louisiana Energy Services, special nuclear material license; Pacific Gas and Electric Company, construction period recovery, facility operating license, Diablo Canyon Nuclear Power plant; and Sequoyah Fuels Corporation, source materials license

Advances in nuclear science and technology

CERN Document Server

Henley, Ernest J

1976-01-01

Advances in Nuclear Science and Technology, Volume 9 provides information pertinent to the fundamental aspects of nuclear science and technology. This book discusses the safe and beneficial development of land-based nuclear power plants.Organized into five chapters, this volume begins with an overview of the possible consequences of a large-scale release of radioactivity from a nuclear reactor in the event of a serious accident. This text then discusses the extension of conventional perturbation techniques to multidimensional systems and to high-order approximations of the Boltzmann equation.

Advances in nuclear science and technology

CERN Document Server

Henley, Ernest J

1972-01-01

Advances in Nuclear Science and Technology, Volume 6 provides information pertinent to the fundamental aspects of nuclear science and technology. This book covers a variety of topics, including nuclear steam generator, oscillations, fast reactor fuel, gas centrifuge, thermal transport system, and fuel cycle.Organized into six chapters, this volume begins with an overview of the high standards of technical safety for Europe's first nuclear-propelled merchant ship. This text then examines the state of knowledge concerning qualitative results on the behavior of the solutions of the nonlinear poin

Pengembangan Perangkat Pembelajaran Matematika Berbasis Problem Based Learning (PBL untuk Meningkatkan Kemampuan Pemecahan Masalah Peserta Didik Kelas VIII

Directory of Open Access Journals (Sweden)

Rizza Yustianingsih

2017-09-01

Full Text Available Abstrak. Berdasarkan hasil penelitian pendahuluan pada kelas VIII SMP di lapangan, masih ditemukan kemampuan pemecahan masalah matematis siswa dalam masalah nyata yang belum optimal dan aktivitas siswa tidak mendukung proses belajar mereka. Salah satu faktornya adalah tidak cocoknya perangkat pembelajaran yang dapat memudahkan pembelajar untuk memperbaiki pemecahan kemampuan matematika dan kemampuan belajar siswa. Dari situ, untuk mendasari melakukan pengembangan perangkat pembelajaran matematika, ada rencana rencana pembelajaran (RPP dan lembar kerja siswa (LKPD berbasis Problem Based Learning (PBL, yang dapat memberikan pengalaman belajar untuk belajar pemecahan masalah dan dapat memberikan efek potensial yang baik pada aktivitas siswa selama proses belajar. Data dikumpulkan melalui observasi, kuesioner, wawancara, dan uji kemampuan pemecahan masalah. Subyek penelitian ini adalah siswa kelas VIII SMP N 3 Sawahlunto. Pengembangan penelitian ini yang digunakan adalah mode Plomp yang terdiri dari tahap awal penelitian, tahap prototipe, dan tahap penilaian. Berdasarkan hasil analisis data, terlihat bahwa alat pembelajaran berdasarkan PBL telah memenuhi kriteria yang valid dalam hal isi dan konstruksi. Peralatan pelajaran telah dianggap praktis dalam hal pelaksanaan dan efisiensi penggunaan waktu oleh guru dan siswa. Alat pelajaran juga efektif dalam hal proses penguasaan presentasi siswa belajar setelah menggunakan pembelajaran berbasis perangkat berbasis pembelajaran lebih besar dari atau sama dengan 75% sedangkan dalam hal hasil rata-rata siswa telah aktif dalam belajar. Kata kunci: Perangkat Pelajaran Matematika, Pemecahan Masalah, PBL.   Abstract. Based on the results of preliminary studies at grade VIII SMP in the field, it is still  found a mathematical problem solving ability of students in real problem who have not optimally and students activities do not support their learning process. One of the  factor is unsuitable of learning tools

Safety hazard Iran? Between nuclear thread and peaceful use of nuclear energy

International Nuclear Information System (INIS)

Schroeter, Lothar

2013-01-01

The volume on Iran between nuclear thread and peaceful use of nuclear energy covers the following contributions: Iran versus USA: labor pains of a new world order; certainties, speculations and lack of knowledge; The nuclear conflict as symptom of deeper conflicts of the Middle East; Peaceful use of nuclear energy? The Iranian nuclear conflict; Satellite broadcast in Iranian backyards; An American invention becoming a doom for the Iran.

Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A

NARCIS (Netherlands)

Collins, P. W.; Blanchette, V. S.; Fischer, K.; Bjorkman, S.; Oh, M.; Fritsch, S.; Schroth, P.; Spotts, G.; Astermark, J.; Ewenstein, B.

Background: The role of prophylactic factor VIII (FVIII) to decrease hemophilic bleeding and arthropathy is well established. The rationale for this strategy is to convert patients with severe hemophilia A to a moderate clinical phenotype by reducing time spent with a FVIII level <1 IU dL(-1).

Nuclear battery materials and application of nuclear batteries

International Nuclear Information System (INIS)

Hao Shaochang; Lu Zhenming; Fu Xiaoming; Liang Tongxiang

2006-01-01

Nuclear battery has lots of advantages such as small volume, longevity, environal stability and so on, therefore, it was widely used in aerospace, deep-sea, polar region, heart pacemaker, micro-electromotor and other fields etc. The application of nuclear battery and the development of its materials promote each other. In this paper the development and the latest research progress of nuclear battery materials has been introduced from the view of radioisotope, electric energy conversion and encapsulation. And the current and potential applications of the nuclear battery are also summarized. (authors)

Proceedings of the US Nuclear Regulatory Commission fifteenth water reactor safety information meeting: Volume 6, Decontamination and decommissioning, accident management, TMI-2

International Nuclear Information System (INIS)

Weiss, A.J.

1988-02-01

This six-volume report contains 140 papers out of the 164 that were presented at the Fifteenth Water Reactor Safety Information Meeting held at the National Bureau of Standards, Gaithersburg, Maryland, during the week of October 26-29, 1987. The papers are printed in the order of their presentation in each session and describe progress and results of programs in nuclear safety research conducted in this country and abroad. This report, Volume 6, discusses decontamination and decommissioning, accident management, and the Three Mile Island-2 reactor accident. Thirteen reports have been cataloged separately

Nuclear fission and neutron-induced fission cross-sections

CERN Document Server

James, G D; Michaudon, A; Michaudon, A; Cierjacks, S W; Chrien, R E

2013-01-01

Nuclear Fission and Neutron-Induced Fission Cross-Sections is the first volume in a series on Neutron Physics and Nuclear Data in Science and Technology. This volume serves the purpose of providing a thorough description of the many facets of neutron physics in different fields of nuclear applications. This book also attempts to bridge the communication gap between experts involved in the experimental and theoretical studies of nuclear properties and those involved in the technological applications of nuclear data. This publication will be invaluable to those interested in studying nuclear fis

Evaluation of the biological differences of canine and human factor VIII in gene delivery: Implications in human hemophilia treatment

Science.gov (United States)

The canine is the most important large animal model for testing novel hemophilia A(HA) treatment. It is often necessary to use canine factor VIII (cFIII) gene or protein for the evaluation of HA treatment in the canine model. However, the different biological properties between cFVIII and human FVII...

High integrity software for nuclear power plants: Candidate guidelines, technical basis and research needs. Main report, Volume 2

International Nuclear Information System (INIS)

Seth, S.; Bail, W.; Cleaves, D.; Cohen, H.; Hybertson, D.; Schaefer, C.; Stark, G.; Ta, A.; Ulery, B.

1995-06-01

The work documented in this report was performed in support of the US Nuclear Regulatory Commission to examine the technical basis for candidate guidelines that could be considered in reviewing and evaluating high integrity computer e following software development and assurance activities: Requirements specification; design; coding; verification and validation, inclukding static analysis and dynamic testing; safety analysis; operation and maintenance; configuration management; quality assurance; and planning and management. Each activity (framework element) was subdivided into technical areas (framework subelements). The report describes the development of approximately 200 candidate guidelines that span the entire ran e identification, categorization and prioritization of technical basis for those candidate guidelines; and the identification, categorization and prioritization of research needs for improving the technical basis. The report has two volumes: Volume 1, Executive Summary includes an overview of the framwork and of each framework element, the complete set of candidate guidelines, the results of the assessment of the technical basis for each candidate guideline, and a discussion of research needs that support the regulatory function; this document, Volume 2, is the main report

High integrity software for nuclear power plants: Candidate guidelines, technical basis and research needs. Main report, Volume 2

Energy Technology Data Exchange (ETDEWEB)

Seth, S.; Bail, W.; Cleaves, D.; Cohen, H.; Hybertson, D.; Schaefer, C.; Stark, G.; Ta, A.; Ulery, B. [Mitre Corp., McLean, VA (United States)

1995-06-01

The work documented in this report was performed in support of the US Nuclear Regulatory Commission to examine the technical basis for candidate guidelines that could be considered in reviewing and evaluating high integrity computer e following software development and assurance activities: Requirements specification; design; coding; verification and validation, inclukding static analysis and dynamic testing; safety analysis; operation and maintenance; configuration management; quality assurance; and planning and management. Each activity (framework element) was subdivided into technical areas (framework subelements). The report describes the development of approximately 200 candidate guidelines that span the entire ran e identification, categorization and prioritization of technical basis for those candidate guidelines; and the identification, categorization and prioritization of research needs for improving the technical basis. The report has two volumes: Volume 1, Executive Summary includes an overview of the framwork and of each framework element, the complete set of candidate guidelines, the results of the assessment of the technical basis for each candidate guideline, and a discussion of research needs that support the regulatory function; this document, Volume 2, is the main report.

Nuclear Knowledge and Competence: Fundamental Prerequisites for the Safe Utilization of Radiation Sources in a Small Non-Nuclear Country — Experience of Montenegro

International Nuclear Information System (INIS)

Jovanovic, S.; Dlabac, A.

2016-01-01

Provision of adequate knowledge, competence and expertise represents a major concern when addressing nuclear and radiation safety issues in small countries — if inadequate, safety will eventually be jeopardized. Montenegro is such a small, developing and “nonnuclear” country—the use of radiation sources being modest and limited to a few ordinary applications (primarily in health care). Even though, there is (or will be in the foreseeable future) a significant need in nuclear knowledge, competence and expertise — directly or indirectly related to nuclear/radiation safety and security issues. It goes about the following, the list being not exhaustive: (i) medical applications (diagnostics, radiotherapy, palliation, sterilization of equipment, consumables, blood products, etc.), (ii) radiation protection, including various dosimetry services and QC/QA of radiation sources; (iii) environmental protection (radioecology, analytical and monitoring services, etc.), (iv) low and medium activity radioactive waste management (including a newly licenced storage), (v) industrial, geological, hydrological, agricultural, biochemical and archaeological applications (non-destructive testing, various gauges, radioisotope labeling, harmful insects sterilization, etc.), (vi) scientific and educational uses, (vii) cultural heritage preservation and investigation, (viii) legislative and regulatory aspects, including complying to international safety/security norms and joining international conventions in the field, (ix) preparedness and response to radiological and nuclear emergency situations, (x) combating illicit trafficking of nuclear and other radioactive materials, (xi) nuclear forensics, (xii) security systems based on X-ray and other nuclear methods, (xiii) introduction of some future topics (e.g., nuclear power for electricity generation and sea water desalination), (xiv) public information and communication with media, etc.

The Fukushima Daiichi Accident. Technical Volume 3/5. Emergency Preparedness and Response. Annexes

International Nuclear Information System (INIS)

2015-08-01

The Fukushima Daiichi Accident consists of a Report by the IAEA Director General and five technical volumes. It is the result of an extensive international collaborative effort involving five working groups with about 180 experts from 42 Member States with and without nuclear power programmes and several international bodies. It provides a description of the accident and its causes, evolution and consequences, based on the evaluation of data and information from a large number of sources available at the time of writing. The Fukushima Daiichi Accident will be of use to national authorities, international organizations, nuclear regulatory bodies, nuclear power plant operating organizations, designers of nuclear facilities and other experts in matters relating to nuclear power, as well as the wider public. The set contains six printed parts and five supplementary CD-ROMs. Contents: Report by the Director General; Technical Volume 1/5, Description and Context of the Accident; Technical Volume 2/5, Safety Assessment; Technical Volume 3/5, Emergency Preparedness and Response; Technical Volume 4/5, Radiological Consequences; Technical Volume 5/5, Post-accident Recovery; Annexes. The Report by the Director General is available separately in Arabic, Chinese, English, French, Russian, Spanish and Japanese

Data collection system. Volume 1, Overview and operators manual; Volume 2, Maintenance manual; Appendices

Energy Technology Data Exchange (ETDEWEB)

Caudell, R.B.; Bauder, M.E.; Boyer, W.B.; French, R.E.; Isidoro, R.J.; Kaestner, P.C.; Perkins, W.G.

1993-09-01

Sandia National Laboratories (SNL) Instrumentation Development Department was tasked by the Defense Nuclear Agency (DNA) to record data on Tektronix RTD720 Digitizers on the HUNTERS TROPHY field test conducted at the Nevada Test Site (NTS) on September 18, 1992. This report contains a overview and description of the computer hardware and software that was used to acquire, reduce, and display the data. The document is divided into two volumes: an overview and operators manual (Volume 1) and a maintenance manual (Volume 2).

Nuclear Regulatory Commission issuances, Volume 44, No. 4

International Nuclear Information System (INIS)

1996-10-01

This report includes the issuances received in October 1996. Issuances are from the Commission, the Atomic Safety and Licensing Boards, and the Directors' Decisions. 15 issuances were received and are abstracted individually in the database: Louisiana Energy Services, U.S. Enrichment Corporation, Yankee Atomic Electric Company, General Public Utilities Nuclear Corporation, James L. Shelton, Juan Guzman, Northern States Power Company, TESTCO Inc., Washington Public Power Supply System, all nuclear plants, Cleveland Electric Illuminating Company, Duke Power Company, Florida Power Corporation, and Northeast Nuclear Energy Company (2 issuances). No issuances were received from the the Administrative Law Judges or the Decisions on Petitions for Rulemaking

Nuclear Regulatory Commission issuances, Volume 44, No. 4

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-10-01

This report includes the issuances received in October 1996. Issuances are from the Commission, the Atomic Safety and Licensing Boards, and the Directors` Decisions. 15 issuances were received and are abstracted individually in the database: Louisiana Energy Services, U.S. Enrichment Corporation, Yankee Atomic Electric Company, General Public Utilities Nuclear Corporation, James L. Shelton, Juan Guzman, Northern States Power Company, TESTCO Inc., Washington Public Power Supply System, all nuclear plants, Cleveland Electric Illuminating Company, Duke Power Company, Florida Power Corporation, and Northeast Nuclear Energy Company (2 issuances). No issuances were received from the the Administrative Law Judges or the Decisions on Petitions for Rulemaking.

Partial volume effect correction in nuclear medicine: assessment with a mathematical phantom

International Nuclear Information System (INIS)

Silva, Murilo Collete da; Pozzo, Lorena

2009-01-01

Objective: assessment of Van Cittert partial volume effect correction method in nuclear medicine images, with a mathematical phantom. Material and method: we simulated an image of four circular sources of different diameters and intensity of 255 per pixel. The iterative algorithm was applied with 20 iterations and α = 1. We obtained the maximum and average counts on the entire image and in regions of interest placed on each of the sources. We also extracted count profiles plotted along the diameter of each of the sources. Results: the local convergence depends on the size of the source studied: the smaller the source, the greater the number of iterations required. It also depends on the information extracted: the use of average counts provides more homogeneous results than the maximum count. There is a significant improvement in image contrast. Conclusion: this study showed the possibility of qualitative and quantitative improvement in applying the bidimensional iterative Van Cittert method to images of simple geometry. (author)

Energies and lifetimes of excited states in copperlike Kr VIII

International Nuclear Information System (INIS)

Livingston, A.E.; Curtis, L.J.; Schectman, R.M.; Berry, H.G.

1980-01-01

The spectrum of Kr VIII has been observed between 180 and 2000 A by using foil excitation of 2.5--3.5-MeV krypton ions. Twenty new transitions have been classified and eleven new excited-state energies have been determined within the n=4 --7 shells. The ionization potential is derived to be 1 015 800 +- 200 cm -1 . The excited-state energies and fine structures are compared with recent relativistic Hartree-Fock calculations. The 4p-state lifetime has been measured by performing a simultaneous analysis of decay data for the 4p level and for its dominant cascade-repopulating levels. The 4p lifetime is found to be 30% shorter than previously measured values and is in excellent agreement with the result of a recent multiconfiguration Hartree-Fock calculation. The source of the discrepancy between this result and earlier measurements is discussed

Proceedings of the international conference on nuclear physics, August 24-30, 1980, Berkeley, California. Volume 1. Abstracts

International Nuclear Information System (INIS)

1980-01-01

This volume contains all abstracts (931) received by the conference organizers before June 20, 1980. The abstracts are grouped according to the following topics: nucleon-nucleon interactions, free and in nuclei; distribution of matter, charge, and magnetism; exotic nuclei and exotic probes; giant resonances and other high-lying excitations; applications of nuclear science; nuclei with large angular momentum and deformation; heavy-ion reactions and relaxation phenomena; new techniques and instruments; pion absorption and scattering by nuclei; and miscellaneous. Some of these one-page abstracts contain data. A complete author index is provided

Indian Point Nuclear Generating Plant Unit No. 3 (Docket No. 50-286): Final environmental statement: Volume 2

International Nuclear Information System (INIS)

1975-02-01

This document contains nine appendices to Volume I, The Final Environmental Impact Statement for the Indian Point Nuclear Generating Plant Unit Number Three. Topics covered include thermal discharges to the Hudson River; supplemental information relating to biological models; radiation effects on aquatic biota; conditions, assumptions, and parameters used in calculating radioactive releases; meteorology for radiological dispersion calculations; life history information of important fish species in the Hudson River near Indian Point; additional information on cooling towers considered as alternatives; data and calculations for assessment of predicted electrical demand; and comments on draft environmental statement

Descripción de un inmunoensayo enzimático que reconoce anticuerpos anti-factor VIII/von Willebrand obtenidos a partir de hibridomas múridos Description of an enzime immunoassay that recognizes anti-factor VIII/von Willebrand antibodies obtained from murine hybridomas

Directory of Open Access Journals (Sweden)

Renée González Sampedro

1999-04-01

Full Text Available Se describe un inmunoensayo enzimático (ELISA que detecta anticuerpos anti-Factor-VIII/von Willebrand (FVIII/vW, con una relación de enlace > 5, que permite reconocer dichos anticuerpos tempranamente en los cultivos de hibridomas múridos. Para la adsorción de las placas del inmunoensayo se utilizaron preparados semipurificados de FVIII/vW obtenidos en Cuba. Se inmunizaron ratones Balb/c con la finalidad de generar los anticuerpos monoclonales detectados por este ELISA. Se obtuvo un clon con crecimiento estable y varios subclones positivos por el ELISA con actividad biológica específica de anticuerpos inhibidores de FVIIIAn enzime immunoassay (ELISA that detects anti-Factor VIII/von Willebrand (FVIII/vw antibodies with a binding relationship > 5 that allows the early recognition of such antibodies in the cultures of murine hybridomas is described. Semipurified preparations of FVIII/vw obtained in Cuba were used for the adsorption of the immunoassay plates. Balb/c mice were immunized in order to generate the monoclonal antibodies detected by this ELISA. A clone with stable growth and several positive subclones were obtained by ELISA with specific biological activity of FVIII-inhibiting antibodies

US Nuclear Regulatory Commission annual report, 1985. Volume 2

International Nuclear Information System (INIS)

1986-01-01

The decisions and actions of the Nuclear Regulatory Commission (NRC) during fiscal year 1985 are reported. Areas covered include reactor regulation, cleanup at Three Mile Island, analysis and evaluation of operational experience, nuclear materials, waste management, safeguards, inspection, enforcement, quality assurance, emergency preparedness, and nuclear regulatory research. Also, cooperation with the states, international programs, proceedings and litigation, and management are discussed

Standard technical specifications: Combustion engineering plants. Volume 1, Revision 1: Specifications

International Nuclear Information System (INIS)

1995-04-01

This report documents the results of the combined effort of the NRC and the industry to produce improved Standard Technical Specifications (STS), Revision 1 for Combustion Engineering Plants. The changes reflected in Revision 1 resulted from the experience gained from license amendment applications to convert to these improved STS or to adopt partial improvements to existing technical specifications. This NUREG is the result of extensive public technical meetings and discussions between the Nuclear Regulatory Commission (NRC) staff and various nuclear power plant licensees, Nuclear Steam Supply System (NSSS) Owners Groups, NSSS vendors, and the Nuclear Energy Institute (NEI). The improved STS were developed based on the criteria in the Final Commission Policy Statement on Technical Specifications Improvements for Nuclear Power Reactors, dated July 22, 1993. The improved STS will be used as the basis for individual nuclear power plant licensees to develop improved plant-specific technical specifications. This report contains three volumes. Volume 1 contains the Specifications for all chapters and sections of the improved STS. Volume 2 contains the Bases for Chapters 2.0 and 3.0, and Sections 3.1--3.3 of the improved STS. Volume 3 contains the Bases for Sections 3.4--3.9 of the improved STS

Advances in nuclear science and technology

CERN Document Server

Henley, Ernest J

1973-01-01

Advances in Nuclear Science and Technology, Volume 7 provides information pertinent to the fundamental aspects of nuclear science and technology. This book discusses the safe and beneficial development of land-based nuclear power plants.Organized into five chapters, this volume begins with an overview of irradiation-induced void swelling in austenitic stainless steels. This text then examines the importance of various transport processes for fission product redistribution, which depends on the diffusion data, the vaporization properties, and the solubility in the fuel matrix. Other chapters co

Report on corrections and future considerations for Appendices II–VIII of the International Code of Nomenclature for Algae, Fungi, and Plants

Science.gov (United States)

For the first time, the main text and Appendices II–VIII of the International Code of Nomenclature were separately published following decisions of the Melbourne Nomenclature Section, which contributed to subsequent development of an online resource capable of producing the Appendices in real time. ...

Nuclear reactors. Introduction

International Nuclear Information System (INIS)

Boiron, P.

1997-01-01

This paper is an introduction to the 'nuclear reactors' volume of the Engineers Techniques collection. It gives a general presentation of the different articles of the volume which deal with: the physical basis (neutron physics and ionizing radiations-matter interactions, neutron moderation and diffusion), the basic concepts and functioning of nuclear reactors (possible fuel-moderator-coolant-structure combinations, research and materials testing reactors, reactors theory and neutron characteristics, neutron calculations for reactor cores, thermo-hydraulics, fluid-structure interactions and thermomechanical behaviour of fuels in PWRs and fast breeder reactors, thermal and mechanical effects on reactors structure), the industrial reactors (light water, pressurized water, boiling water, graphite moderated, fast breeder, high temperature and heavy water reactors), and the technology of PWRs (conceiving and building rules, nuclear parks and safety, reactor components and site selection). (J.S.)

Nuclear Regulatory Commission issuances, January 1997. Volume 45, Number 1

International Nuclear Information System (INIS)

1997-01-01

This book contains issuances of the Atomic Safety and Licensing Board, Nuclear Regulatory Commission and Director's Decision for January 1997. The issuances concern Sequoyah Fuels Corporation and General Atomics Gore, Oklahoma Site decontamination and decommissioning funding; Louisiana Energy Services, Claiborne Enrichment Center denies appeal to review emergency planning; General Public Utilities Nuclear Corporation, Oyster Creek Nuclear Generating station, challenges to technical specifications concerning spent fuel pool; and Consumers Power Company, Palisades Nuclear Plant dry cask storage of spent nuclear fuel

Protection against nuclear terrorism: the IAEA response

International Nuclear Information System (INIS)

Dodd, B.

2002-01-01

Full text: As a result of the events of 11 September 2001, the International Atomic Energy Agency (IAEA) identified possible threats from acts of nuclear terrorism. A report to the Board of Governors in November 2001 summarized the IAEA's ongoing work in areas relevant to the prevention and mitigation of the consequences of such acts and outlined proposals for a number of new and/or enhanced activities. Four main threats were addressed: theft of a nuclear weapon; acquisition of nuclear material; acquisition of other radioactive material; and violent acts against nuclear facilities. These proposals have been further refined and the new plan was approved in principle at the March 2002 board meeting. In the beginning, implementation will be dependent on member state contributions to a voluntary fund. Proposed new or enhanced activities are grouped into eight areas: I. Physical protection of nuclear material and nuclear facilities; II. Detection of malicious activities involving nuclear and other radioactive materials; III. State systems for nuclear material accountancy and control; IV. Security of radioactive material other than nuclear material; V. Assessment of safety/security related vulnerability of nuclear facilities; VI. Response to malicious acts, or threats thereof; VII. Adherence to and implementation of international agreements, guidelines and recommendations; VIII. Nuclear security co-ordination and information management. After an overview, this paper focuses on activity area IV, which deals with the radiological terrorism issues involving radioactive sources. A strategy for evaluation of the IAEA's role is presented, covering an analysis of the likely threats and possible scenarios. This leads to an assessment of the most desirable sources from a terrorist's viewpoint. The strategy then examines how terrorists might acquire such sources and attempts to determine the best ways to prevent their acquisition. Further activities are proposed to prevent the use

Fixed site neutralization model programmer's manual. Volume II

International Nuclear Information System (INIS)

Engi, D.; Chapman, L.D.; Judnick, W.; Blum, R.; Broegler, L.; Lenz, J.; Weinthraub, A.; Ballard, D.

1979-12-01

This report relates to protection of nuclear materials at nuclear facilities. This volume presents the source listings for the Fixed Site Neutralization Model and its supporting modules, the Plex Preprocessor and the Data Preprocessor

The legal position of nuclear ships according to the drafts of the third UN-conference on the law of the sea

International Nuclear Information System (INIS)

Rauschning, D.G.

1978-01-01

At the end of the 6th session of the Third UN-Conference on the Law of the Sea an Informal Composite Negotiating text has emerged. Art. 19 ICNT, which defines innocent passage, contains no express limitation on nuclear shipping, while Art. 23 presupposes that nuclear ships have this right, provided they carry documents and observe special precautionary measures established by international agreements. A certificate of nuclear safety pursuant to Chapter VIII of SOLAS must be recognized by contracting states and coastal states may require liability coverage. Coastal state lack competences to regulate design, construction, manning or equipment of foreign ships or to impose requirements which have the practical effect of denying innocent passage. The right of passage also prevails in the special economic zones and in archipelagic waters

X-ray spectral line coincidences between fluorine VIII (and IX) and transition metal lines

International Nuclear Information System (INIS)

Charatis, G.; Rockett, P.D.; Burkhalter, P.G.

1983-01-01

X-ray spectroscopy was performed in the 12 to 15 A region, recording L-shell lines from selected laser-irradiated transition metals. Line coincidences and near coincidences were identified between Fe, Cr, Mn, and Ni L-spectra, and F VIII and F IX K-shell lines. Wavelengths were determined to accuracies of 1 to 3 mA and will be utilized in selecting potential pumping candidates in future x-ray lasing schemes. High-resolution x-ray spectra were collected under controlled illumination and target conditions using 1.05 μm and 0.527 μm laser excitation with the KMS CHROMA laser

PENERAPAN MODEL PEMBELAJARAN BAKULIKAN UNTUK MENINGKATKAN KEMAMPUAN BERSIKAP ILMIAH PADA KONSEP PEMANTULAN CAHAYA KELAS VIII

Directory of Open Access Journals (Sweden)

N. A. Shofiah

2012-01-01

Full Text Available Penelitian tindakan kelas yang bertujuan untuk meningkatkan kemampuan bersikap ilmiah, telah dilakukan di kelas VIII semester IIpada sub pokok bahasan pemantulan cahaya. Untuk meningkatkan kemampuan bersikap ilmiah diterapkan model pembelajaranbakulikan. Penelitian tindakan kelas ini terdiri dari tiga sikus, dengan masing-masing siklus terdiri dari empat tahapan yaituperencanaan, pelaksanaan, observasi dan refleksi. Data sikap ilmiah siswa diambil dari lembar angket dan lembar observasi. Datahasil belajar kognitif diambil dari evaluasi yang ada di LKS tiap akhir siklus dan data hasil belajar psikomotorik diambil dari lembarobservasi tiap akhir siklus. Hasil penelitian menyatakan bahwa sikap ilmiah siswa mengalami peningkatan walaupun tidaksignifikan. Hasil belajar kognitif dan keterampilan psikomotorik siswa mengalami peningkatan tiap siklus dan mencapai ketuntasanpada siklus III. A classroom action research aimed to improve scientific attitude skill had been done in second semester of grade VIII MTs on thesubtopic light reflection. The 'bakulikan' learning model was chosen for improving the scientific attitude skills of the students. Thisaction research consisted of three cycles, and each cycle has four stages, namely, planning, conducting, observation andreflection. The data obtained through questionnaire and observation sheets. The cognitive achievement drawn from the evaluationon each worksheet at the end of each cycle, and the psychometrics recorded from observation sheet. The study concludes that thescientific attitude skill improved significantly. The achievement on cognitive and psychometrics increase gradually on each cycleand get mastery at the end of the last cycle.Keywords: bakulikan; classroom action research; scientific attitude

Nuclear fuel cycle. International overview. Updating of volume 1

International Nuclear Information System (INIS)

1985-01-01

It is presented the updating of the vol.I of the 'Nuclear fuel cycle - International overview' series which informs about the nuclear fuel cycle in the main countries that supply and /or use nuclear energy. It intends to serve the managerial staff since it gives a global view of the fuel cycle as well as its extent in each of the countries focalized. Information about Japan, Federal Republic of Germany, United Kingdon, France and Canada are presented. At first a summary about the situation of each country is presented and then all data for each country is presented in a tree - graphyic type, using an analysis and synthesis method, developed at the Nuclear Information Center, Brazil. (E.G.) [pt

Round Robin Test for Performance Demonstration System of Ultrasound Examination Personnel in Nuclear Power Plants

International Nuclear Information System (INIS)

Kim, Young Ho; Yang, Seung Han; Kim, Yong Sik; Yoon, Byung Sik; Lee, Hee Jong

2005-01-01

Ultrasound testing performance during in-service inspection for the main components of NPPs is strongly affected by each examination person. Therefore, ASME established a more strict qualification requirement in Sec. XI Appendix VIII for the ultrasound testing personnel in nuclear power plants. The Korean Performance Demonstration (KPD) System according to the ASME code for the ultrasonic testing personnel, equipments, and procedures to apply to the Class 1 and 2 piping ultrasound examination of nuclear power plants in Korea was established. And a round robin test was conducted in order to verify the effectiveness of PD method by comparing the examination results from the method of Performance Demonstration (PD) and a traditional ASME code dB-drop method. The round robin test shows that the reliability of the PD method is better than that of the dB-drop method. As a result, application of the PD method to the in-service inspection of the nuclear power plants will improve the performance of ultrasound testing

Investigations of possibilities to dispose of spent nuclear fuel in Lithuania: a model case. Volume 2, Concept of Repository in Crystalline Rocks

International Nuclear Information System (INIS)

Motiejunas, S.; Poskas, P.

2005-01-01

The aim is to present the generic repository concept in crystalline rocks in Lithuania and cost assessment of the disposal of spent nuclear fuel and long-lived intermediate level waste in this repository. Due to limited budget of this project the repository concept development for Lithuania was based mostly on the experience of foreign countries. In this Volume a review of the existing information on disposal concept in crystalline rocks from various countries is presented. Described repository concept for crystalline rocks in Lithuania covers repository layout, backfill, canister, construction materials and auxiliary buildings. Costs calculations for disposal of spent nuclear fuel and long-lived intermediate-level wastes from Ignalina NPP are presented too. Thermal, criticality and other important disposal evaluations for RBMK-1500 spent nuclear fuel emplaced in copper canister were performed and described

Nuclear Power Options Viability Study. Volume 4. Bibliography

Energy Technology Data Exchange (ETDEWEB)

Trauger, D B; White, J D; Sims, J W [eds.

1986-09-01

Documents in the Nuclear Power Options Viability Study (NPOVS) bibliography are classified under one of four headings or categories as follows: nuclear options; light water reactors; liquid metal reactors; and high temperature reactors. The collection and selection of these documents, beginning early in 1984 and continuing through March of 1986, was carried out in support of the study's objective: to explore the viabilities of several nuclear electric power generation options for commercial deployment in the United States between 2000 and 2010. There are approximately 550 articles, papers, reports, and books in the bibliography that have been selected from some 2000 surveyed. The citations have been made computer accessible to facilitate rapid on-line retrieval by keyword, author, corporate author, title, journal name, or document number.

Nuclear Power Options Viability Study. Volume 4. Bibliography

International Nuclear Information System (INIS)

Trauger, D.B.; White, J.D.; Sims, J.W.

1986-09-01

Documents in the Nuclear Power Options Viability Study (NPOVS) bibliography are classified under one of four headings or categories as follows: nuclear options; light water reactors; liquid metal reactors; and high temperature reactors. The collection and selection of these documents, beginning early in 1984 and continuing through March of 1986, was carried out in support of the study's objective: to explore the viabilities of several nuclear electric power generation options for commercial deployment in the United States between 2000 and 2010. There are approximately 550 articles, papers, reports, and books in the bibliography that have been selected from some 2000 surveyed. The citations have been made computer accessible to facilitate rapid on-line retrieval by keyword, author, corporate author, title, journal name, or document number

Vol. 2: Nuclear Physics

International Nuclear Information System (INIS)

Sitenko, A.

1993-01-01

Problems of modern physics and the situation with physical research in Ukraine are considered. Programme of the conference includes scientific and general problems. Its proceedings are published in 6 volumes. The papers presented in this volume refer to nuclear physics

Advances in nuclear science and technology

CERN Document Server

Henley, Ernest J

1970-01-01

Advances in Nuclear Science and Technology, Volume 5 presents the underlying principles and theory, as well as the practical applications of the advances in the nuclear field. This book reviews the specialized applications to such fields as space propulsion.Organized into six chapters, this volume begins with an overview of the design and objective of the Fast Flux Test Facility to provide fast flux irradiation testing facilities. This text then examines the problem in the design of nuclear reactors, which is the analysis of the spatial and temporal behavior of the neutron and temperature dist

Advances in nuclear science and technology

CERN Document Server

Greebler, Paul

1966-01-01

Advances in Nuclear Science and Technology, Volume 3 provides an authoritative, complete, coherent, and critical review of the nuclear industry. This book presents the advances in the atomic energy field.Organized into six chapters, this volume begins with an overview of the use of pulsed neutron sources for the determination of the thermalization and diffusion properties of moderating as well as multiplying media. This text then examines the effect of nuclear radiation on electronic circuitry and its components. Other chapters consider radiation effects in various inorganic solids, with empha

Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs

Science.gov (United States)

Dumont, Jennifer A.; Liu, Tongyao; Low, Susan C.; Zhang, Xin; Kamphaus, George; Sakorafas, Paul; Fraley, Cara; Drager, Douglas; Reidy, Thomas; McCue, Justin; Franck, Helen W. G.; Merricks, Elizabeth P.; Nichols, Timothy C.; Bitonti, Alan J.; Pierce, Glenn F.

2012-01-01

Despite proven benefits, prophylactic treatment for hemophilia A is hampered by the short half-life of factor VIII. A recombinant factor VIII-Fc fusion protein (rFVIIIFc) was constructed to determine the potential for reduced frequency of dosing. rFVIIIFc has an ∼ 2-fold longer half-life than rFVIII in hemophilia A (HemA) mice and dogs. The extension of rFVIIIFc half-life requires interaction of Fc with the neonatal Fc receptor (FcRn). In FcRn knockout mice, the extension of rFVIIIFc half-life is abrogated, and is restored in human FcRn transgenic mice. The Fc fusion has no impact on FVIII-specific activity. rFVIIIFc has comparable acute efficacy as rFVIII in treating tail clip injury in HemA mice, and fully corrects whole blood clotting time (WBCT) in HemA dogs immediately after dosing. Furthermore, consistent with prolonged half-life, rFVIIIFc shows 2-fold longer prophylactic efficacy in protecting HemA mice from tail vein transection bleeding induced 24-48 hours after dosing. In HemA dogs, rFVIIIFc also sustains partial correction of WBCT 1.5- to 2-fold longer than rFVIII. rFVIIIFc was well tolerated in both species. Thus, the rescue of FVIII by Fc fusion to provide prolonged protection presents a novel pathway for FVIII catabolism, and warrants further investigation. PMID:22246033

EK(b)P Keskkomitee VIII pleenumi stenogramm / tõlk. Mart Arold, tõlk. Jaan Isotamm

Index Scriptorium Estoniae

1999-01-01

EK(b)P Keskkomitee VIII pleenum, 21.-23. märts 1950. Sõnavõtud: N. Karotamm, P. Ponomarenko, I. Käbin, V. Kuusik, A. Jaanus, V. Hiznjakov, E. Ristimägi, I. Suija, H. Ajo, A. Meri, G. Abels, M. Assin, G. Latõshov, Rumjantsev, Müürisepp. Kommenteerinud Viktor Niitsoo. Algus: Akadeemia (1998) nr. 12, lk. 2655-2683 ; Järg nr.2;3;4;5;6;7;8;9;10 lk.415-446;639-670;863-894;1087-1118;1310-1342;1534-1566;1759-1790;2017-2048;2220-2256

Volume dependence of N-body bound states

Science.gov (United States)

König, Sebastian; Lee, Dean

2018-04-01

We derive the finite-volume correction to the binding energy of an N-particle quantum bound state in a cubic periodic volume. Our results are applicable to bound states with arbitrary composition and total angular momentum, and in any number of spatial dimensions. The only assumptions are that the interactions have finite range. The finite-volume correction is a sum of contributions from all possible breakup channels. In the case where the separation is into two bound clusters, our result gives the leading volume dependence up to exponentially small corrections. If the separation is into three or more clusters, there is a power-law factor that is beyond the scope of this work, however our result again determines the leading exponential dependence. We also present two independent methods that use finite-volume data to determine asymptotic normalization coefficients. The coefficients are useful to determine low-energy capture reactions into weakly bound states relevant for nuclear astrophysics. Using the techniques introduced here, one can even extract the infinite-volume energy limit using data from a single-volume calculation. The derived relations are tested using several exactly solvable systems and numerical examples. We anticipate immediate applications to lattice calculations of hadronic, nuclear, and cold atomic systems.

Low-dose factor VIII infusion in Chinese adult haemophilia A patients: pharmacokinetics evidence that daily infusion results in higher trough level than with every-other-day infusion with similar factor VIII consumption.

Science.gov (United States)

Hua, B; Lee, A; Fan, L; Li, K; Zhang, Y; Poon, M-C; Zhao, Y

2017-05-01

Pharmacokinetics (PK) modelling suggests improvement of trough levels are achieved by using more frequent infusion strategy. However, no clinical study data exists to confirm or quantify improvement in trough level, particularly for low-dose prophylaxis in patients with haemophilia A. To provide evidence that low dose daily (ED) prophylaxis can increase trough levels without increasing FVIII consumption compared to every-other-day (EOD) infusion. A cross-over study on 5 IU kg -1 FVIII daily vs. 10 IU kg -1 EOD infusions, each for 14 days was conducted at the PUMCH-HTC. On the ED schedule, trough (immediate prior to infusion), and peak FVIII:C levels (30 min after infusion) were measured on days 1-5; and trough levels alone on days 7, 9, 11 and 13. For the EOD schedule, troughs, peaks and 4-h postinfusion were measured on day 1; troughs and peaks on days 3, 5, and 7; troughs alone on days 9, 11 and 13 and 24-h postinfusion on days 2, 4 and 6. FVIII inhibitors were assessed on days 0 and 14 during both infusion schedules. Six patients were enrolled. PK evidence showed that daily prophylaxis achieved higher (~2 times) steady-state FVIII trough levels compared to EOD with the same total factor consumption. The daily prophylaxis had good acceptability among patients and reduced chronic pain in the joints in some patients. Our PK study shows low-dose factor VIII daily infusion results in higher trough level than with EOD infusion with similar factor VIII consumption in Chinese adult haemophilia A patients. © 2017 John Wiley & Sons Ltd.

Reprocessing of the spent nuclear fuel, I-VIII, Part IV, Engineering drawings, C - Sampling equipment; Prerada isluzenog nuklearnog goriva, I-VIII, IV Deo, Konstruktivni crtezi, C - Uredjaj za uzimanje uzoraka

Energy Technology Data Exchange (ETDEWEB)

Gal, I [Institute of Nuclear Sciences Boris Kidric, Laboratorija za hemiju visoke aktivnosti, Vinca, Beograd (Serbia and Montenegro)

1963-02-15

This volume includes the engineering drawings of the sampling equipment which is part of the pilot device for for extracting uranium, plutonium and fission products from the fuel irradiated in the reactor.

Flow-induced vibration -- 1994. PVP-Volume 273

International Nuclear Information System (INIS)

Au-Yang, M.K.; Fujita, K.

1994-01-01

Flow-induced vibration is a subject of practical interest to many engineering disciplines, including the power generation, process, and petrochemical industries. In the nuclear industry, flow-induced vibration reaches a higher level of concern because of safety issues and the huge cost associated with down time and site repair. Not surprisingly, during the last 25 years a tremendous amount of effort has been spent in the study of flow-induced vibration phenomena related to nuclear plant components, notably nuclear steam generator tube banks and nuclear fuel bundles. Yet, in spite of this concentrated effort, the industry is still not free from flow-induced vibration-related problems. This explains why in this volume almost half of the papers address the issue of cross-flow induced vibration in tube bundles, with applications to the nuclear steam generator and nuclear fuel bundles in mind. Unlike 10 or 15 years ago, when flow-induced vibration studies almost always involved experimentation and empirical studies, the advent of high-speed computers has enabled numerical calculation and simulation of this complex phenomenon to take place. Separate abstracts were prepared for 27 papers in this volume

Research program for seismic qualification of nuclear plant electrical and mechanical equipment. Task 3. Recommendations for improvement of equipment qualification methodology and criteria. Volume 3

International Nuclear Information System (INIS)

Kana, D.D.; Pomerening, D.J.

1984-08-01

The Research Program for Seismic Qualification of Nuclear Plant Electrical and Mechanical Equipment has spanned a period of three years and resulted in seven technical summary reports, each of which covered in detail the findings of different tasks and subtasks, and have been combined into five NUREG/CR volumes. Volume 3 presents recommendations for improvement of equipment qualification methodology and procedural clarification/modification. The fifth category identifies issues where adequate information does not exist to allow a recommendation to be made

Standard technical specifications General Electric plants, BWR/6. Volume 1, Revision 1

International Nuclear Information System (INIS)

1995-04-01

This report documents the results of the combined effort of the NRC and the industry to produce improved Standard Technical Specifications (STS), Revision 1 for General Electric BWR/6 Plants. The changes reflected in Revision 1 resulted from the experience gained from license amendment applications to convert to these improved STS or to adopt partial improvements to existing technical specifications. This NUREG is the result of extensive public technical meetings and discussions between the Nuclear Regulatory Commission (NRC) staff and various nuclear power plant licensees, Nuclear Steam Supply System (NSSS) Owners Groups, NSSS vendors, and the Nuclear Energy Institute (NEI). The improved STS were developed based on the criteria in the Final Commission Policy Statement on Technical Specifications Improvements for Nuclear Power Reactors, dated July 22, 1993. The improved STS will be used as the basis for individual nuclear power plant licensees to develop improved plant-specific technical specifications. This report contains three volumes. Volume 1 contains the Specifications for all chapters and sections of the improved STS. Volume 2 contains the Bases for Chapters 2.0 and 3.0, and Sections 3.1--3.3 of the improved STS. Volume 3 contains the Bases for Sections 3.4--3.10 of the improved STS

India's nuclear security

International Nuclear Information System (INIS)

Thomas, Raju G.C.; Gupta, Amit

2000-01-01

The nuclear weapons and ballistic missile tests conducted by India and Pakistan in the late 1990s substantially altered the security environment, both in the region and globally. Examining the complexities, and dynamics of this new strategic context, this timely and significant book examines the claim of many Indian strategists that stability in the region is better served under conditions of declared-rather than covertly developed-nuclear weapons. Bringing together original essays by a diverse group of scholars, this volume discusses a number of important issues such as: the political considerations that caused India and Pakistan to go nuclear; the type of nuclear doctrine that is likely to emerge and its implications for the safety of nuclear weapons, the potential for an arms race in the region, and the likelihood of war; the political and economic consequences for India after Pokhran-II and the impact of economic sanctions; the technological ramifications of the nuclear program on India's defence science scenario; the impact of these tests on the future of India's relationship with the United States, the main bulwark against nuclear weapons proliferation, also, the changed role that India sees for itself in international fora; the possible arms control measures that might succeed in stabilizing the South Asian nuclear rivalry. This insightful, comprehensive and topical volume is a must-read for all those in the fields of political science, international relations, strategic affairs, conflict/peace studies, economics, and policy studies

Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume IX. Reactor and fuel cycle descriptions

Energy Technology Data Exchange (ETDEWEB)

1979-12-01

The Nonproliferation Alternative Systems Assessment Program (NASAP) has characterized and assessed various reactor/fuel-cycle systems. Volume IX provides, in summary form, the technical descriptions of the reactor/fuel-cycle systems studied. This includes the status of the system technology, as well as a discussion of the safety, environmental, and licensing needs from a technical perspective. This information was then used in developing the research, development, and demonstration (RD and D) program, including its cost and time frame, to advance the existing technology to the level needed for commercial use. Wherever possible, the cost data are given as ranges to reflect the uncertainties in the estimates. Volume IX is divided into three sections: Chapter 1, Reactor Systems; Chapter 2, Fuel-Cycle Systems; and the Appendixes. Chapter 1 contains the characterizations of the following 12 reactor types: light-water reactor; heavy-water reactor; water-cooled breeder reactor; high-temperature gas-cooled reactor; gas-cooled fast reactor; liquid-metal fast breeder reactor; spectral-shift-controlled reactor; accelerator-driven reactor; molten-salt reactor; gaseous-core reactor; tokamak fusion-fisson hybrid reactor; and fast mixed-spectrum reactor. Chapter 2 contains similar information developed for fuel-cycle facilities in the following categories: mining and milling; conversion and enrichment; fuel fabrication; spent fuel reprocessing; waste handling and disposal; and transportation of nuclear materials.

Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume IX. Reactor and fuel cycle descriptions

International Nuclear Information System (INIS)

1979-12-01

The Nonproliferation Alternative Systems Assessment Program (NASAP) has characterized and assessed various reactor/fuel-cycle systems. Volume IX provides, in summary form, the technical descriptions of the reactor/fuel-cycle systems studied. This includes the status of the system technology, as well as a discussion of the safety, environmental, and licensing needs from a technical perspective. This information was then used in developing the research, development, and demonstration (RD and D) program, including its cost and time frame, to advance the existing technology to the level needed for commercial use. Wherever possible, the cost data are given as ranges to reflect the uncertainties in the estimates. Volume IX is divided into three sections: Chapter 1, Reactor Systems; Chapter 2, Fuel-Cycle Systems; and the Appendixes. Chapter 1 contains the characterizations of the following 12 reactor types: light-water reactor; heavy-water reactor; water-cooled breeder reactor; high-temperature gas-cooled reactor; gas-cooled fast reactor; liquid-metal fast breeder reactor; spectral-shift-controlled reactor; accelerator-driven reactor; molten-salt reactor; gaseous-core reactor; tokamak fusion-fisson hybrid reactor; and fast mixed-spectrum reactor. Chapter 2 contains similar information developed for fuel-cycle facilities in the following categories: mining and milling; conversion and enrichment; fuel fabrication; spent fuel reprocessing; waste handling and disposal; and transportation of nuclear materials

The Fukushima Daiichi Accident. Technical Volume 1/5. Description and Context of the Accident. Annexes

International Nuclear Information System (INIS)

2015-08-01

The Fukushima Daiichi Accident consists of a Report by the IAEA Director General and five technical volumes. It is the result of an extensive international collaborative effort involving five working groups with about 180 experts from 42 Member States with and without nuclear power programmes and several international bodies. It provides a description of the accident and its causes, evolution and consequences, based on the evaluation of data and information from a large number of sources available at the time of writing. The Fukushima Daiichi Accident will be of use to national authorities, international organizations, nuclear regulatory bodies, nuclear power plant operating organizations, designers of nuclear facilities and other experts in matters relating to nuclear power, as well as the wider public. The set contains six printed parts and five supplementary CD-ROMs. Contents: Report by the Director General; Technical Volume 1/5, Description and Context of the Accident; Technical Volume 2/5, Safety Assessment; Technical Volume 3/5, Emergency Preparedness and Response; Technical Volume 4/5, Radiological Consequences; Technical Volume 5/5, Post-accident Recovery; Annexes. The Report by the Director General is available separately in Arabic, Chinese, English, French, Russian, Spanish and Japanese

Nuclear medicine

International Nuclear Information System (INIS)

Chamberlain, M.J.

1986-01-01

Despite an aggressive, competitive diagnostic radiology department, the University Hospital, London, Ontario has seen a decline of 11% total (in vivo and in the laboratory) in the nuclear medicine workload between 1982 and 1985. The decline of in vivo work alone was 24%. This trend has already been noted in the U.S.. Nuclear medicine is no longer 'a large volume prosperous specialty of wide diagnostic application'

DNFSB Recommendation 94-1 Hanford Site Integrated Stabilization Management Plan. Volume 2

International Nuclear Information System (INIS)

Gerber, E.W.

1995-10-01

The Hanford Site Integrated Stabilization Management Plan (SISMP) was developed in support of the US Department of Energy's (DOE) Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 94-1 Integrated Program Plan (IPP). Volume 1 of the SISMP identifies the technical scope and costs associated with Hanford Site plans to resolve concerns identified in DNFSB Recommendation 94-1. Volume 2 of the SISMP provides the Resource Loaded Integrated Schedules for Spent Nuclear Fuel Project and Plutonium Finishing Plant activities identified in Volume 1 of the SISMP. Appendix A provides the schedules and progress curves related to spent nuclear fuel management. Appendix B provides the schedules and progress curves related to plutonium-bearing material management. Appendix C provides programmatic logic diagrams that were referenced in Volume 1 of the SISMP

Nuclear- and radiochemistry. Vol. 2. Modern applications

International Nuclear Information System (INIS)

Roesch, Frank

2016-01-01

This work is conceived to meet the demand of state-of-the-art literature to teach the fundamentals as well as the modern applications of nuclear chemistry. The work will consist of two volumes: the first one covering the basics of nuclear chemistry such as the relevant parameters of instable atomic nuclei, the various modi of radioactive transmutations, the corresponding types of radiation including their detection and dosimetry, and finally the mechanisms of nuclear reactions. The second volume addresses relevant fields of nuclear chemistry, such as the chemistry of radioactive elements, application of radioactive nuclei in life sciences, nuclear energy, waste managements and environmental aspects, radiochemical separations, radioanalytical and spectroscopic methods, etc. Here, leading experts will contribute up-to-date knowledge on the most important application of nuclear chemistry.

Recurrent myocardial infarctions in a young football player secondary to thrombophilia, associated with elevated factor VIII activity

Directory of Open Access Journals (Sweden)

Vacek TP

2014-10-01

Full Text Available Thomas P Vacek, Shipeng Yu, Shahnaz Rehman, Blair P Grubb, Daniel Kosinski, Cherian Verghese, Ehab A Eltahawy, Shafiq Qaiser Department of Medicine, University of Toledo Medical Center, Toledo, OH, USAAbstract: Myocardial infarction (MI due to coronary atherosclerosis in young adults is uncommon; rare causes such as cocaine abuse, arterial dissection, and thromboembolism should be considered. A 21-year-old football player, and otherwise healthy African American man, developed chest pain during exercise while bench-pressing 400 lbs. Acute MI was diagnosed based on physical examination, electrocardiography findings, and elevated cardiac enzymes. Coronary arteriography showed a thrombus occluding the proximal left anterior descending artery (LAD. Aggressive antiplatelet therapy with aspirin, clopidogrel, and eptifibatide was pursued, in addition to standard post-MI care. This led to the successful resolution of symptoms and dissolution of the thrombus, demonstrated by repeat coronary arteriography. Five months later, he presented with similar symptoms during exercise after lifting heavy weights, and was found to have another acute MI. Coronary arteriography again showed a thrombus occluding the LAD. No evidence of coronary artery dissection or vasospasm was found. Only mild atherosclerotic plaque burden was observed on both occasions by intravascular ultrasound. A bare metal stent was placed at the site as it was thought this site had acted as a nidus for small plaque rupture and thrombus formation. Elevated serum factor VIII activity at 205% (reference range 60%–140% was found, a rare cause of hypercoagulability. Further workup revealed a patent foramen ovale during a Valsalva maneuver by transesophageal echocardiography. Both events occurred during weight lifting, which can transiently increase right heart pressure in a similar way to the Valsalva maneuver. In light of all the findings, we concluded that an exercise-related increase in factor

Stable nuclear transformation of Eudorina elegans

Directory of Open Access Journals (Sweden)

Lerche Kai

2013-02-01

Full Text Available Abstract Background A fundamental step in evolution was the transition from unicellular to differentiated, multicellular organisms. Volvocine algae have been used for several decades as a model lineage to investigate the evolutionary aspects of multicellularity and cellular differentiation. There are two well-studied volvocine species, a unicellular alga (Chlamydomonas reinhardtii and a multicellular alga with differentiated cell types (Volvox carteri. Species with intermediate characteristics also exist, which blur the boundaries between unicellularity and differentiated multicellularity. These species include the globular alga Eudorina elegans, which is composed of 16–32 cells. However, detailed molecular analyses of E. elegans require genetic manipulation. Unfortunately, genetic engineering has not yet been established for Eudorina, and only limited DNA and/or protein sequence information is available. Results Here, we describe the stable nuclear transformation of E. elegans by particle bombardment using both a chimeric selectable marker and reporter genes from different heterologous sources. Transgenic algae resistant to paromomycin were achieved using the aminoglycoside 3′-phosphotransferase VIII (aphVIII gene of Streptomyces rimosus, an actinobacterium, under the control of an artificial promoter consisting of two V. carteri promoters in tandem. Transformants exhibited an increase in resistance to paromomycin by up to 333-fold. Co-transformation with non-selectable plasmids was achieved with a rate of 50 - 100%. The luciferase (gluc gene from the marine copepod Gaussia princeps, which previously was engineered to match the codon usage of C. reinhardtii, was used as a reporter gene. The expression of gluc was mediated by promoters from C. reinhardtii and V. carteri. Heterologous heat shock promoters induced an increase in luciferase activity (up to 600-fold at elevated temperatures. Long-term stability and both constitutive and

Department of Energy Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs, Draft Environmental Impact Statement. Volume 1, Appendix D: Part A, Naval Spent Nuclear Fuel Management

Energy Technology Data Exchange (ETDEWEB)

1994-06-01