Sample records for volume ptv margins

  1. Volume study pre and post-implant brachytherapy prostate for establishment of PTV margins; Estudio de volumenes pre y post-implante en braquiterapia de prostata para establecimiento de margenes del PTV

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    Jimenez Dominguez, M.; Carrasco Herrera, M.; Baeza Trujillo, M.; Herrador Cordoba, M.


    Treatment of prostate cancer by permanent implantation of radioactive seeds is now a good alternative to radical surgery or radiotherapy, as it provides a good tumor control while the risk is reduced by a lower complication irradiation of adjacent healthy organs. The large volume change during seed implantation occurs in the prostate of the patient, makes it important to consider margins around the organs of interest both to ensure optimal coverage and minimal tumor irradiation of healthy tissue. Analyze how the volume varies during and after implantation and establish a margin around the prostate to the practice of our hospital are the two objectives of this work.

  2. SU-E-T-36: An Investigation of the Margin From CTV to PTV Using Retraction Method for Cervical Carcinoma

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    Wu, D; Chen, J; Hao, Y; Liao, C; Huang, Y; Mo, Y; Wei, Y [The People' s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi (China)


    Purpose: This work employs the retraction method to compute and evaluate the margin from CTV to PTV based on the influence of target dosimetry of setup errors during cervical carcinoma patients treatment. Methods: Sixteen patients with cervical cancer were treated by Elekta synergy and received a total of 305 KV-CBCT images. The iso-center of the initial plans were changed according to the setup errors to simulate radiotherapy and then recalculated the dose distribution using leaf sequences and MUs for individual plans. The margin from CTV to PTV will be concluded both by the method of retracting (Fixed the PTV of the original plan, and retract PTV a certain distance defined as simulative organization CTVnx. The minimum distance value from PTV to CTVnx which get specified doses, namely guarantee at least 99% CTV volume can receive the dose of 95%, is the margin CTV to PTV we found) and the former formula method. Results: (1)The setup errors of 16 patients in X, Y and Z directions were(1.13±2.94) mm,(−1.63±7.13) mm,(−0.65±2.25) mm. (2) The distance between CTVx and PTV was 5, 9 and 3mm in X, Y and Z directions According to 2.5+0.7σ. (3) Transplantation plans displayed 99% of CTVx10- CTVx7 and received 95% of prescription dose, but CTVx6- CTVx3 departed from standard of clinic.In order to protect normal tissues, we selected 7mm as the minimum value of the margin from CTV to PTV. Conclusion: We have test an retraction method for the margin from CTV to PTV evaluation. The retraction method is more reliable than the formula method for calculating the margin from the CTV to the PTV, because it represented practice of treatment, and increasing a new method in this field.

  3. Planning target volume (PTV) definition and its effects in the radiotherapy; Definicao do volume de planejamento do alvo (PTV) e seu efeito na radioterapia

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    Poli, Maria Esmeralda Ramos


    Tills work intends to study the margins required to define a planning target volume (PTV) for adequate treatment of the mobile tumors such as prostate or those located in areas with less mobility as the ones in head and neck region, in the absence of daily localization imaging based. It is also intends to evaluate the impact caused by the PTV, in terms of dose, to the critical structures surrounding the PTV and its influence when inverse planning is used in the intensity-modulated radiation therapy (IMRT). Data from 387 prostate patients were analyzed retrospectively. Every patient in the study received daily pre-treatment localization with 2D ultrasound resulting in a total of 10,327 localizations, each comprising of an isocenter displacement in 3 directions: anterior-posterior (AP), right-left lateral (RL), and superior-inferior (SI). The mean displacement and standard deviation (SD) for each direction for each patient was computed from daily treatment records. The uncertainties (SD) in the target position were 4.4 mm (AP), 3.6 mm (RL), and 4.5 mm (SI). A study of the uncertainties in the daily positioning of 78 head and neck patients who used thermoplastic mask to immobilize them, evaluated with electronic portal imaging device (EPID), showed variations (SD) in the isocenter treatment position of 3.1 mm (AP), 1.5 mm (RL), and 4.5 mm (SI). By applying these shifts in an anthropomorphic phantom it was studied the dose-volume histograms resultant of the isocenter displacement in the daily treatment. The result showed the importance of putting margins in the clinical target volume to assure an adequate treatment and also showed that isocenter daily variation can cause an increase to the dose greater than the tolerance level to the critical organs. (author)

  4. Rotation Effects on the Target-Volume Margin Determination

    CERN Document Server

    Zhang, Qinghui; Chan, M; Song, Y; Burman, C


    Rotational setup errors are usually neglected in most clinical centers. An analytical formula is developed to determine the extra margin between clinical target volume (CTV) and planning target volume (PTV) to account for setup errors. The proposed formula corrects for both translational and rotational setup errors and then incorporated into margin determination for PTV.

  5. Analysis of PTV margin for IMRT and VMAT techniques in prostate cancer using IGRT; Analise de margem de PTV para as tecnicas de IMRT e VMAT em cancer de prostata utilizando IGRT

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    Sandrini, E.S.; Silveira, T.B.; Vieira, D.S.; Anjos, L.E.A.; Lopez, J.C.C.; Batista, D.V.S., E-mail: [Instituto Nacional de Cancer Jose de Alencar Gomes da Silva, Rio de Janeiro, RJ (Brazil)


    Clinical radiotherapy procedures aim at high precision. However, there are many errors sources that act during treatment preparation and execution that limit its accuracy. The use of imaged-guided radiotherapy (IGRT) increases the agreement between the planned dose and the actual dose deposited in the target, at the same time allows to evaluate the uncertainties related to the setup and a possible reduction in the planning target volume (PTV) margin. Thus the aim of this study was to determine the best PTV margin to be used in radiotherapy treatment of prostate cancer using intensity modulated radiotherapy (IMRT) and volumetric modulated arc radiotherapy (VMAT) techniques associated with IGRT. A total of four patients with prostate daily cone beam computed tomography (CBCT) were analyzed. Systematic and random errors were calculated statistically based on the displacements couch for 128 CBCTs. It was found that a symmetric margin of 0.75 cm from clinical treatment volume (CTV) to PTV is sufficient to encompass the uncertainties inherent to the treatment applying IGRT. Besides without that and maintaining the same tumor control probability, a symmetric margin of 1,24 cm would be necessary. This study showed that using daily image verification the setup errors are reduced, which generates a lower PTV margin. (author)

  6. 4D-Listmode-PET-CT and 4D-CT for optimizing PTV margins in gastric lymphoma. Determination of intra- and interfractional gastric motion

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    Reinartz, Gabriele; Haverkamp, Uwe; Wullenkord, Ramona; Lehrich, Philipp; Kriz, Jan; Eich, Hans Theodor [University Hospital Muenster, Department of Radiation Oncology, Muenster (Germany); Buether, Florian [University of Muenster, European Institute for Molecular Imaging (EIMI), Muenster (Germany); Schaefers, Klaus [University of Muenster, European Institute for Molecular Imaging (EIMI), Muenster (Germany); DFG EXC 1003, Cluster of Excellence ' Cells in Motion' , Muenster (Germany); Schaefers, Michael [University of Muenster, European Institute for Molecular Imaging (EIMI), Muenster (Germany); University Hospital Muenster, Department of Nuclear Medicine, Muenster (Germany); DFG EXC 1003, Cluster of Excellence ' Cells in Motion' , Muenster (Germany)


    New imaging protocols for radiotherapy in localized gastric lymphoma were evaluated to optimize planning target volume (PTV) margin and determine intra-/interfractional variation of the stomach. Imaging of 6 patients was explored prospectively. Intensity-modulated radiotherapy (IMRT) planning was based on 4D/3D imaging of computed tomography (CT) and positron-emission tomography (PET)-CT. Static and motion gross tumor volume (sGTV and mGTV, respectively) were distinguished by defining GTV (empty stomach), clinical target volume (CTV = GTV + 5 mm margin), PTV (GTV + 10/15/20/25 mm margins) plus paraaortic lymph nodes and proximal duodenum. Overlap of 4D-Listmode-PET-based mCTV with 3D-CT-based PTV (increasing margins) and V95/D95 of mCTV were evaluated. Gastric shifts were determined using online cone-beam CT. Dose contribution to organs at risk was assessed. The 4D data demonstrate considerable intra-/interfractional variation of the stomach, especially along the vertical axis. Conventional 3D-CT planning utilizing advancing PTV margins of 10/15/20/25 mm resulted in rising dose coverage of mCTV (4D-Listmode-PET-Summation-CT) and rising D95 and V95 of mCTV. A PTV margin of 15 mm was adequate in 3 of 6 patients, a PTV margin of 20 mm was adequate in 4 of 6 patients, and a PTV margin of 25 mm was adequate in 5 of 6 patients. IMRT planning based on 4D-PET-CT/4D-CT together with online cone-beam CT is advisable to individualize the PTV margin and optimize target coverage in gastric lymphoma. (orig.) [German] Zur Optimierung des Sicherheitsabstandes beim Planungszielvolumen (PTV) und zur Erfassung der intra-/interfraktionellen Variation des Magens wurden neue Protokolle fuer die Bildverarbeitung in der Radiotherapie lokalisierter Magenlymphome evaluiert. Die Bildgebung von 6 Patienten wurde prospektiv untersucht. Die Planung der intensitaetsmodulierten Strahlentherapie (IMRT) basierte auf 4D-/3D-Bildgebung von Computertomographie (CT) und Positronenemissionstomographie

  7. SU-E-J-177: A Computational Approach for Determination of Anisotropic PTV Margins Based On Statistical Shape Analysis for Prostate Cancer Radiotherapy

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    Shibayama, Y; Arimura, H; Nakamura, K; Honda, H; Toyofuku, F [Kyushu University, Fukuoka, JP (Japan); Hirose, T; Umezu, Y; Nakamura, Y [Kyushu University Hospital, Fukuoka, JP (Japan)


    Purpose: Our aim of this study was to propose a computational approach for determination of anisotropic planning target volume (PTV) margins based on statistical shape analysis with taking into account time variations of clinical target volume (CTV) shapes for the prostate cancer radiation treatment planning (RTP). Methods: Systematic and random setup errors were measured using orthogonal projection and cone beam computed tomography (CBCT) images for data of 20 patients, who underwent the intensity modulated radiation therapy for prostate cancer. The low-risk, intermediate-risk, and high-risk CTVs were defined as only a prostate, a prostate plus proximal 1-cm seminal vesicles, and a prostate plus proximal 2-cm seminal vesicles, respectively. All CTV regions were registered with a reference CTV region with a median volume to remove the effect of the setup errors, and converted to a point distribution models. The systematic and random errors for translations of CTV regions were automatically evaluated by analyzing the movements of centroids of CTV regions. The random and systematic errors for shape variations of CTV regions were obtained from covariance matrices based on point distributions for the CTV contours on CBCT images of 72 fractions of 10 patients. Anisotropic PTV margins for 6 directions (right, left, anterior, posterior, superior and inferior) were derived by using Yoda’s PTV margin model. Results: PTV margins with and without shape variations were 5.75 to 8.03 mm and 5.23 to 7.67 mm for low-risk group, 5.87 to 8.33 mm and 5.23 to 7.67 mm for intermediate-risk group, and 5.88 to 8.25 mm and 5.29 to 7.82 mm for highrisk group, respectively. Conclusion: The proposed computational approach could be feasible for determination of the anisotropic PTV margins with taking into account CTV shape variations for the RTP.

  8. Verification of PTV margins for IMRT prostate cancer using EPID; Verificacao das margens de PTV para IMRT de cancer de prostata utilizando EPID

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    Leidens, Matheus; Santos, Romulo R.; Estacio, Daniela R. [Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Porto Alegre, RS (Brazil). Hospital Sao Lucas. Servico de Fisica Medica; Silva, Ana Maria Marques da, E-mail: [Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Porto Alegre, RS (Brazil). Faculdade de Fisica


    The aim of this work is to present the results of a strategy to define the PTV margins for patients with prostate cancer treated with IMRT technique, due to geometrical uncertainties associated with the planned placement. 341 images of 31 patients in supine position, before applying the fractions, were obtained using an EPID attached to a linear accelerator, where only setup errors were studied. The displacements were analyzed in relation to the AP (antero-posterior), SI (superior-inferior) and LR (left-right) directions. The distribution pattern of systematic displacement deviation values were 0.12 cm, 0.06 cm, 0.02 cm and the standard deviation of the distribution of random deviations was 0.62 cm, 0.53 cm, and 0.24 cm in the AP, SI and LR directions, respectively. Data evaluation, according to Stroom and Heijmen’s method, suggests that PTV margins should be 0.66 cm in the AP direction, 0.49 cm in the SI direction and 0.20 cm in the LR direction. These data show a high reproducibility in the positioning of patients, given by a method for the correction of planned relative to the bony anatomy checked with the EPID position. (author)

  9. Determination of optimal PTV margin for patients receiving CBCT-guided prostate IMRT: comparative analysis based on CBCT dose calculation with four different margins. (United States)

    Gill, Sukhdeep K; Reddy, Krishna; Campbell, Nina; Chen, Changhu; Pearson, David


    Variations in daily setup and rectum/bladder filling lead to uncertainties in the delivery of prostate IMRT. The purpose of this study is to determine the optimal PTV margin for CBCT-guided prostate IMRT based on daily CBCT dose calculations using four different margins. Five patients diagnosed with low-risk prostate cancer were treated with prostate IMRT to 70 Gy in 28 fractions using daily CBCT for image guidance. The prostate CTV and OARs were contoured on all CBCTs. IMRT plans were created using 1 mm, 3 mm, 5 mm, and 7 mm CTV to PTV expansions. For each delivered fraction, dose calculations were generated utilizing the pretreatment CBCT translational shifts performed and dosimetric analysis was performed. One hundred and forty total treatment fractions (CBCT sessions) were evaluated. The planned prostate CTV V100% was 100% for all PTV margins. Based on CBCT analysis, the actual cumulative CTVs V100% were 96.55% ± 2.94%, 99.49% ± 1.36%, 99.98% ± 0.26%, and 99.99% ± 0.05% for 1, 3, 5, and 7 mm uniform PTV margins, respectively. Delivered rectum and bladder doses were different as compared to expected planned doses, with the magnitude of differences increasing with PTV margin. Daily setup variation during prostate IMRT yields differences in the actual vs. expected doses received by the prostate CTV, rectum, and bladder. The magnitude of these differences is significantly affected by the PTV margin utilized. It was found that when daily CBCT was used for soft-tissue alignment of the prostate, a 3 mm PTV margin allowed for CTV to be covered for 99% of cases.

  10. Set-up errors analyses in IMRT treatments for nasopharyngeal carcinoma to evaluate time trends, PTV and PRV margins

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    Mongioj, Valeria (Dept. of Medical Physics, Fondazione IRCCS Istituto Nazionale Tumori, Milan (Italy)), e-mail:; Orlandi, Ester (Dept. of Radiotherapy, Fondazione IRCCS Istituto Nazionale Tumori, Milan (Italy)); Palazzi, Mauro (Dept. of Radiotherapy, A.O. Niguarda Ca' Granda, Milan (Italy)) (and others)


    Introduction. The aims of this study were to analyze the systematic and random interfractional set-up errors during Intensity Modulated Radiation Therapy (IMRT) in 20 consecutive nasopharyngeal carcinoma (NPC) patients by means of Electronic Portal Images Device (EPID), to define appropriate Planning Target Volume (PTV) and Planning Risk Volume (PRV) margins, as well as to investigate set-up displacement trend as a function of time during fractionated RT course. Material and methods. Before EPID clinical implementation, an anthropomorphic phantom was shifted intentionally 5 mm to all directions and the EPIs were compared with the digitally reconstructed radiographs (DRRs) to test the system's capability to recognize displacements observed in clinical studies. Then, 578 clinical images were analyzed with a mean of 29 images for each patient. Results. Phantom data showed that the system was able to correct shifts with an accuracy of 1 mm. As regards clinical data, the estimated population systematic errors were 1.3 mm for left-right (L-R), 1 mm for superior-inferior (S-I) and 1.1 mm for anterior-posterior (A-P) directions, respectively. Population random errors were 1.3 mm, 1.5 mm and 1.3 mm for L-R, S-I and A-P directions, respectively. PTV margin was at least 3.4, 3 and 3.2 mm for L-R, S-I and A-P direction, respectively. PRV margins for brainstem and spinal cord were 2.3, 2 and 2.1 mm and 3.8, 3.5 and 3.2 mm for L-R, A-P and S-I directions, respectively. Set-up error displacements showed no significant changes as the therapy progressed (p>0.05), although displacements >3 mm were found more frequently when severe weight loss or tumor nodal shrinkage occurred. Discussion. These results enable us to choose margins that guarantee with sufficient accuracy the coverage of PTVs and organs at risk sparing. Collected data confirmed the need for a strict check of patient position reproducibility in case of anatomical changes

  11. SU-C-BRE-05: PTV Margin Determination Based On Tumor Radiobiological Characteristics and Geometric Uncertainties Derived From Daily Cone- Beam CT Images

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    Selvaraj, J [Inlaks and Budhrani Hospital (India)


    Purpose: To determine required PTV margins for ≤1% loss in mean population TCP using systematic (Σ) and random (σ) errors calculated from daily cone-beam CT (CBCT) images of head and neck patients. Methods: Daily CBCT images were acquired for 50 head and neck patients. The CBCT image sets acquired at each fraction were registered with planning CT to obtain positional errors for each patient for each fraction. Systematic and random errors were calculated from data collected for 50 patients as described in IPEM On Target report. CTV delineation uncertainty of 2mm is added quadratically to systematic error. Assuming a spherical target volume, the dose in each voxel of target volume is summed for each fraction in the treatment by shifting the dose grid to calculate mean population TCP inclusive of geometric uncertainties using a Monte Carlo method. These simulations were repeated for the set of Σ and σ in each axis for different PTV margins and drop in TCP for each margin are obtained. In order to study the effect of dose-response curve on PTV margins, two different σα of 0.048 Gy-1 and 0.218 Gy-1 representing steep and shallow dose-response curves are studied. Σ were 2.5, 2.5, 2.1 mm and σ were 0.3, 0.3 0.2 mm respectively in x, y and z axis respectively. Results: PTV margins based on tumor radiobiological characteristics are 4.8, 4.8 and 4 mm in x, y and z axis assuming 25 treatment fractions for σα 0.048 Gy-1 (steep) and 4.2,4.2 and 2.2 for σα of 0.218 Gy-1 (shallow). While the TCP-based margins did not differ much in x and y axis, it is considerably smaller in z axis for shallow DRC. Conclusion: TCP based margins are substantially smaller than physical dose-based margin recipes. This study also demonstrates the importance of considering tumor radiobiological characteristics while deriving margins.

  12. Verification of the patient positioning for evaluation of PTV margins in radiotherapy of prostate cancer; Verificacao do posicionamento do paciente para a avaliacao das margens de PTV em radioterapia do cancer de prostata

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    Frohlich, B.F.; Peron, T.M.; Scheid, A.M.; Cardoso, F.; Alves, F.; Alves, M.S.; Dias, T.M. [Hospital de Clinicas de Porto Alegre, RS (Brazil)


    The work aimed to verify the relative displacements between the patient and the isocenters of the device based on the reproducibility of positioning, and estimates a PTV margins of radiotherapy treatments for prostate cancer. The results of displacements were obtained from a sample of 30 patient and showed values in vertical, longitudinal and lateral directions -0.03 ± 0.48 cm, 0.12 ± 0.47 cm and 0.02 ± 0.53 cm, respectively. PTV margins were calculated resulting in 0.97 cm for vertical direction, 0.85 cm for longitudinal, and 0.98 cm for lateral. (author)

  13. SU-E-J-30: Benchmark Image-Based TCP Calculation for Evaluation of PTV Margins for Lung SBRT Patients

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    Li, M [Wayne State Univeristy, Detroit, MI (United States); Chetty, I [Henry Ford Health System, Detroit, MI (United States); Zhong, H [Henry Ford Hospital System, Detroit, MI (United States)


    Purpose: Tumor control probability (TCP) calculated with accumulated radiation doses may help design appropriate treatment margins. Image registration errors, however, may compromise the calculated TCP. The purpose of this study is to develop benchmark CT images to quantify registration-induced errors in the accumulated doses and their corresponding TCP. Methods: 4DCT images were registered from end-inhale (EI) to end-exhale (EE) using a “demons” algorithm. The demons DVFs were corrected by an FEM model to get realistic deformation fields. The FEM DVFs were used to warp the EI images to create the FEM-simulated images. The two images combined with the FEM DVF formed a benchmark model. Maximum intensity projection (MIP) images, created from the EI and simulated images, were used to develop IMRT plans. Two plans with 3 and 5 mm margins were developed for each patient. With these plans, radiation doses were recalculated on the simulated images and warped back to the EI images using the FEM DVFs to get the accumulated doses. The Elastix software was used to register the FEM-simulated images to the EI images. TCPs calculated with the Elastix-accumulated doses were compared with those generated by the FEM to get the TCP error of the Elastix registrations. Results: For six lung patients, the mean Elastix registration error ranged from 0.93 to 1.98 mm. Their relative dose errors in PTV were between 0.28% and 6.8% for 3mm margin plans, and between 0.29% and 6.3% for 5mm-margin plans. As the PTV margin reduced from 5 to 3 mm, the mean TCP error of the Elastix-reconstructed doses increased from 2.0% to 2.9%, and the mean NTCP errors decreased from 1.2% to 1.1%. Conclusion: Patient-specific benchmark images can be used to evaluate the impact of registration errors on the computed TCPs, and may help select appropriate PTV margins for lung SBRT patients.

  14. Impact of inter- and intrafraction deviations and residual set-up errors on PTV margins. Different alignment techniques in 3D conformal prostate cancer radiotherapy

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    Langsenlehner, T.; Doeller, C.; Winkler, P.; Kapp, K.S. [Graz Medical Univ. (Austria). Dept. of Therapeutic Radiology and Oncology; Galle, G. [Graz Medical Univ. (Austria). Dept. of Urology


    The aim of this work was to analyze interfraction and intrafraction deviations and residual set-up errors (RSE) after online repositioning to determine PTV margins for 3 different alignment techniques in prostate cancer radiotherapy. The present prospective study included 44 prostate cancer patients with implanted fiducials treated with three-dimensional (3D) conformal radiotherapy. Daily localization was based on skin marks followed by marker detection using kilovoltage (kV) imaging and subsequent patient repositioning. Additionally, in-treatment megavoltage (MV) images were obtained for each treatment field. In an off-line analysis of 7,273 images, interfraction prostate motion, RSE after marker-based prostate localization, prostate position during each treatment session, and the effect of treatment time on intrafraction deviations were analyzed to evaluate PTV margins. Margins accounting for interfraction deviation, RSE and intrafraction motion were 14.1, 12.9, and 15.1 mm in anterior-posterior (AP), superior-inferior (SI), and left-right (LR) direction for skin mark alignment and 9.6, 8.7, and 2.6 mm for bony structure alignment, respectively. Alignment to implanted markers required margins of 4.6, 2.8, and 2.5 mm. As margins to account for intrafraction motion increased with treatment prolongation PTV margins could be reduced to 3.9, 2.6, and 2.4 mm if treatment time was {<=} 4 min. With daily online correction and repositioning based on implanted fiducials, a significant reduction of PTV margins can be achieved. The use of an optimized workflow with faster treatment techniques such as volumetric modulated arc techniques (VMAT) could allow for a further decrease. (orig.)

  15. Study of limiting dosimetric parameters on lung pathology. Differences in the use of the lung-gtv and lung-ptv volumes; Estudio de los parametros dosimetricos limitantes en la patologia de pulmon diferencias en ul uso de los volumenes pulmon-gtv y pulmo-ptv

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    Granero Cabanero, D.; Almendros Blanco, P.; Garcia Hernanez, T.; Vicedo gonzalez, A.; Brualla, L.; Hernandez, A.; Solera, C.; Serrano, A.; Rosello, J.


    The objective of this work is to study the differences between the use of the volume of lung-GTV and lung-PTV to assess pulmonary toxicity and also to study the relationships between parameters V13, V20, V30, and mean dose of volumes lung, lung-PTV and lung-GTV. It was studied also the possible relationship between volumes of GTV, PTV and volume of lung with the dosimetric parameters described above. (Author)

  16. SU-E-J-39: Comparison of PTV Margins Determined by In-Room Stereoscopic Image Guidance and by On-Board Cone Beam Computed Tomography Technique for Brain Radiotherapy Patients

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    Ganesh, T; Paul, S; Munshi, A; Sarkar, B; Krishnankutty, S; Sathya, J; George, S; Jassal, K; Roy, S; Mohanti, B [Fortis Memorial Research Institute, Gurgaon (India)


    Purpose: Stereoscopic in room kV image guidance is a faster tool in daily monitoring of patient positioning. Our centre, for the first time in the world, has integrated such a solution from BrainLAB (ExacTrac) with Elekta's volumetric cone beam computed tomography (XVI). Using van Herk's formula, we compared the planning target volume (PTV) margins calculated by both these systems for patients treated with brain radiotherapy. Methods: For a total of 24 patients who received partial or whole brain radiotherapy, verification images were acquired for 524 treatment sessions by XVI and for 334 sessions by ExacTrac out of the total 547 sessions. Systematic and random errors were calculated in cranio-caudal, lateral and antero-posterior directions for both techniques. PTV margins were then determined using van Herk formula. Results: In the cranio-caudal direction, systematic error, random error and the calculated PTV margin were found to be 0.13 cm, 0.12 cm and 0.41 cm with XVI and 0.14 cm, 0.13 cm and 0.44 cm with ExacTrac. The corresponding values in lateral direction were 0.13 cm 0.1 cm and 0.4 cm with XVI and 0.13 cm, 0.12 cm and 0.42 cm with ExacTrac imaging. The same parameters for antero-posterior were for 0.1 cm, 0.11 cm and 0.34 cm with XVI and 0.13 cm, 0.16 cm and 0.43 cm with ExacTrac imaging. The margins estimated with the two imaging modalities were comparable within ± 1 mm limit. Conclusion: Verification of setup errors in the major axes by two independent imaging systems showed the results are comparable and within ± 1 mm. This implies that planar imaging based ExacTrac can yield equal accuracy in setup error determination as the time consuming volumetric imaging which is considered as the gold standard. Accordingly PTV margins estimated by this faster imaging technique can be confidently used in clinical setup.

  17. In situ calibrated defocusing PTV for wall-bounded measurement volumes (United States)

    Fuchs, T.; Hain, R.; Kähler, C. J.


    In many situations, 3D velocity measurements in thin (∼1 mm) but wide (∼100  ×  100 mm2) flow channels is an important task. To resolve the in-plane and out-of-plane velocity gradients properly, a precise calibration is required, since 3D measurement approaches rely strongly on the accuracy of the calibration procedure. It is likely that calibration targets do not fit domains with small depths, due to their size. Furthermore, in fields where such measurements are of interest, the accessibility of the measurement volume is often limited or even impossible. To overcome these drawbacks, this paper introduces an in situ calibrated defocusing particle tracking velocimetry approach for wall-bounded measurement domains with depths in the low millimeter range. The calibration function for the particle depth location is directly derived from the particle image geometries and their displacements between two frames. Employing only a single camera, this defocusing approach is capable of measuring the air flow between two parallel glass plates at a distance of 1 mm with an average uncertainty of 2.43% for each track, relative to the maximum velocity. A tomographic particle tracking velocimetry measurement, serving as a benchmark for the single camera technique, reaches an average uncertainty of 1.59%. Altogether, with its straightforward set-up and without requiring a calibration target, this in situ calibrated defocusing approach opens new areas of application for optical flow velocimetry. In particular, for measurement domains with small optical windows and a lack of accessibility.

  18. Optimized planning target volume margin in helical tomotherapy for prostate cancer: is there a preferred method?

    CERN Document Server

    Cao, Yuan Jie; Chang, Kyung Hwan; Shim, Jang Bo; Kim, Kwang Hyeon; Jang, Min Sun; Yoon, Won Sup; Yang, Dae Sik; Park, Young Je; Kim, Chul Yong


    To compare the dosimetrical differences between plans generated by helical tomotherapy using 2D or 3D margining technique in in prostate cancer. Ten prostate cancer patients were included in this study. For 2D plans, planning target volume (PTV) was created by adding 5 mm (lateral/anterior-posterior) to clinical target volume (CTV). For 3D plans, 5 mm margin was added not only in lateral/anterior-posterior, but also in superior-inferior to CTV. Various dosimetrical indices, including the prescription isodose to target volume (PITV) ratio, conformity index (CI), homogeneity index (HI), target coverage index (TCI), modified dose homogeneity index (MHI), conformation number (CN), critical organ scoring index (COSI), and quality factor (QF) were determined to compare the different treatment plans. Differences between 2D and 3D PTV indices were not significant except for CI (p = 0.023). 3D margin plans (11195 MUs) resulted in higher (13.0%) monitor units than 2D margin plans (9728 MUs). There were no significant d...

  19. Multi-scenario based robust intensity-modulated proton therapy (IMPT) plans can account for set-up errors more effectively in terms of normal tissue sparing than planning target volume (PTV) based intensity-modulated photon plans in the head and neck region. (United States)

    Stuschke, Martin; Kaiser, Andreas; Abu Jawad, Jehad; Pöttgen, Christoph; Levegrün, Sabine; Farr, Jonathan


    In a previous report, we compared the conformity of robust intensity-modulated proton therapy (IMPT) plans with that of helical tomotherapy plans for re-irradiations of head and neck carcinomas using a fixed set-up error of 2 mm. Here, we varied the maximum set-up errors between 0 and 5 mm and compared the robust IMPT-plans with planning target volume (PTV) based intensity-modulated photon therapy (IMRT). Seven patients were treated with a PTV-based tomotherapy plan. Set-up margins of 0, 2, and 5 mm were subtracted from the PTV to generate target volumes (TV) TV(0mm), TV(2mm), and TV(5mm), for which robust IMPT-plans were created assuming range uncertainties of ±3.5% and using worst case optimization assuming set-up errors of 0, 2, and 5 mm, respectively. Robust optimization makes use of the feature that set-up errors in beam direction alone do not affect the distal and proximal margin for that beam. With increasing set-up errors, the body volumes that were exposed to a selected minimum dose level between 20% and 95% of the prescribed dose decreased. In IMPT-plans with 0 mm set-up error, the exposed body volumes were on average 6.2% ± 0.9% larger than for IMPT-plans with 2 mm set-up error, independent of the considered dose level (p plans accounting for 5 mm set-up error, the exposed body volumes were by 11.9% ± 0.8% smaller than for IMPT-plans with 2 mm set-up error at a fixed minimum dose (p plans corresponding to the same IMRT-plan led to a decrease in the mean dose to the temporal lobes and the cerebellum, and in the D2% of the brain stem or spinal cord with increasing set-up errors considered during robust IMPT-planning. For recurrent head and neck cancer, robust IMPT-plan optimization led to a decrease in normal tissue exposure with increasing set-up error for target volumes corresponding to the same PTV.

  20. Effect of lung and target density on small-field dose coverage and PTV definition

    Energy Technology Data Exchange (ETDEWEB)

    Higgins, Patrick D., E-mail:; Ehler, Eric D.; Cho, Lawrence C.; Dusenbery, Kathryn E.


    We have studied the effect of target and lung density on block margin for small stereotactic body radiotherapy (SBRT) targets. A phantom (50 × 50 × 50 cm{sup 3}) was created in the Pinnacle (V9.2) planning system with a 23-cm diameter lung region of interest insert. Diameter targets of 1.6, 2.0, 3.0, and 4.0 cm were placed in the lung region of interest and centered at a physical depth of 15 cm. Target densities evaluated were 0.1 to 1.0 g/cm{sup 3}, whereas the surrounding lung density was varied between 0.05 and 0.6 g/cm{sup 3}. A dose of 100 cGy was delivered to the isocenter via a single 6-MV field, and the ratio of the average dose to points defining the lateral edges of the target to the isocenter dose was recorded for each combination. Field margins were varied from none to 1.5 cm in 0.25-cm steps. Data obtained in the phantom study were used to predict planning treatment volume (PTV) margins that would match the clinical PTV and isodose prescription for a clinical set of 39 SBRT cases. The average internal target volume (ITV) density was 0.73 ± 0.17, average local lung density was 0.33 ± 0.16, and average ITV diameter was 2.16 ± 0.8 cm. The phantom results initially underpredicted PTV margins by 0.35 cm. With this offset included in the model, the ratio of predicted-to-clinical PTVs was 1.05 ± 0.32. For a given target and lung density, it was found that treatment margin was insensitive to target diameter, except for the smallest (1.6-cm diameter) target, for which the treatment margin was more sensitive to density changes than the larger targets. We have developed a graphical relationship for block margin as a function of target and lung density, which should save time in the planning phase by shortening the design of PTV margins that can satisfy Radiation Therapy Oncology Group mandated treatment volume ratios.

  1. Comparison of planning target volumes based on three-dimensional and four-dimensional CT imaging of thoracic esophageal cancer. (United States)

    Wang, Wei; Li, Jianbin; Zhang, Yingjie; Shao, Qian; Xu, Min; Fan, Tingyong; Wang, Jinzhi


    To investigate the definition of planning target volumes (PTVs) based on four-dimensional computed tomography (4DCT) compared with conventional PTV definition and PTV definition using asymmetrical margins for thoracic primary esophageal cancer. Forty-three patients with esophageal cancer underwent 3DCT and 4DCT simulation scans during free breathing. The motions of primary tumors located in the proximal (group A), middle (group B), and distal (group C) thoracic esophagus were obtained from the 4DCT scans. PTV3D was defined on 3DCT using the tumor motion measured based on 4DCT, PTV conventional (PTVconv) was defined on 3DCT by adding a 1.0 cm margin to the clinical target volume, and PTV4D was defined as the union of the target volumes contoured on the ten phases of the 4DCT images. The centroid positions, volumetric differences, and dice similarity coefficients were evaluated for all PTVs. The median centroid shifts between PTV3D and PTV4D and between PTVconv and PTV4D in all three dimensions were groups. The median size ratios of PTV4D to PTV3D were 0.80, 0.88, and 0.71, and PTV4D to PTVconv were 0.67, 0.73, and 0.76 (χ (2)=-3.18, -2.98, and -3.06; P=0.001, 0.003, and 0.002) for groups A, B, and C, respectively. The dice similarity coefficients were 0.87, 0.90, and 0.81 between PTV4D and PTV3D and 0.80, 0.84, and 0.83 between PTV4D and PTVconv (χ (2) =-3.18, -2.98, and -3.06; P=0.001, 0.003, and 0.002) for groups A, B, and C, respectively. The difference between the degree of inclusion of PTV4D in PTV3D and that of PTV4D in PTVconv was groups. Compared with PTVconv, the amount of irradiated normal tissue for PTV3D was decreased by 11.81% and 11.86% in groups A and B, respectively, but was increased by 2.93% in group C. For proximal and middle esophageal cancer, 3DCT-based PTV using asymmetrical margins provides good coverage of PTV4D; however, for distal esophageal cancer, 3DCT-based PTV using conventional margins provides ideal conformity with PTV4D.

  2. Three Dimensional Expansion of Margins for Single-fraction Treatments: Stereotactic Radiosurgery Brain Cases

    CERN Document Server

    Zhang, Qinghui; Song, Yulin; Burman, Chandra


    Purpose: To derive a clinical margin formula between clinical target volume (CTV) and planning target volume (PTV) for single-fraction stereotactic radiosurgery (SRS). Methods: In previous publications on the margin between CTV and PTV, a Gaussian function with zero mean sys-tematic error was assumed for systematic errors and the machine systematic error was ignored; in this work we pre-sumed a Dirac delta function for the machine systematic error for a given machine and nonzero mean systematic error was assumed. Mathematical formulas for calculating the CTV-PTV margin for single-fraction SRS cases was proposed. Results: Margins for single fraction treatment were derived such that the CTV receives the prescribed dose in 95% of SRS patients. The margins defined in this study were machine specific and account for nonzero mean systematic error. The differences between our formulas and a previously published formula were discussed. Conclusion: Clinical margin formulas are proposed for determining the margin betwe...

  3. Validation of Planning Target Volume Margins by Analyzing Intrafractional Localization Errors for 14 Prostate Cancer Patients Based on Three-Dimensional Cross-Correlation between the Prostate Images of Planning CT and Intrafraction Cone-Beam CT during Volumetric Modulated Arc Therapy

    Directory of Open Access Journals (Sweden)

    Kenshiro Shiraishi


    Full Text Available Time-averaged intreatment prostate localization errors were calculated, for the first time, by three-dimensional prostate image cross-correlation between planning CT and intrafraction kilovoltage cone-beam CT (CBCT during volumetric modulated arc therapy (VMAT. The intrafraction CBCT volume was reconstructed by an inhouse software after acquiring cine-mode projection images during VMAT delivery. Subsequently, the margin between a clinical target volume and a planning target volume (PTV was obtained by applying the van Herk and variant formulas using the calculated localization errors. The resulting PTV margins were approximately 2 mm in lateral direction and 4 mm in craniocaudal and anteroposterior directions, which are consistent with the margin prescription employed in our facility.

  4. The effect of uterine motion and uterine margins on target and normal tissue doses in intensity modulated radiation therapy of cervical cancer

    Energy Technology Data Exchange (ETDEWEB)

    Gordon, J J; Weiss, E; Abayomi, O K; Siebers, J V; Dogan, N, E-mail: [Department of Radiation Oncology, Virginia Commonwealth University, PO Box 980058, Richmond, VA 23298 (United States)


    In intensity modulated radiation therapy (IMRT) of cervical cancer, uterine motion can be larger than cervix motion, requiring a larger clinical target volume to planning target volume (CTV-to-PTV) margin around the uterine fundus. This work simulates different motion models and margins to estimate the dosimetric consequences. A virtual study used image sets from ten patients. Plans were created with uniform margins of 1 cm (PTV{sub A}) and 2.4 cm (PTV{sub C}), and a margin tapering from 2.4 cm at the fundus to 1 cm at the cervix (PTV{sub B}). Three inter-fraction motion models (MM) were simulated. In MM1, all structures moved with normally distributed rigid body translations. In MM2, CTV motion was progressively magnified as one moved superiorly from the cervix to the fundus. In MM3, both CTV and normal tissue motion were magnified as in MM2, modeling the scenario where normal tissues move into the void left by the mobile uterus. Plans were evaluated using static and percentile DVHs. For a conventional margin (PTV{sub A}), quasi-realistic uterine motion (MM3) reduces fundus dose by about 5 Gy and increases normal tissue volumes receiving 30-50 Gy by {approx}5%. A tapered CTV-to-PTV margin can restore fundus and CTV doses, but will increase normal tissue volumes receiving 30-50 Gy by a further {approx}5%.

  5. Three independent one-dimensional margins for single-fraction frameless stereotactic radiosurgery brain cases using CBCT

    CERN Document Server

    Zhang, Qinghui; Burman, Chandra; Song, Yulin; Zhang, Mutian


    Setting a proper margin is crucial for not only delivering the required radiation dose to a target volume, but also reducing the unnecessary radiation to the adjacent organs at risk. This study investigated the independent one-dimensional symmetric and asymmetric margins between the clinical target volume (CTV) and the planning target volume (PTV) for linac-based single-fraction frameless stereotactic radiosurgery (SRS).

  6. Comparison of planning target volumes based on three-dimensional and four-dimensional CT imaging of thoracic esophageal cancer

    Directory of Open Access Journals (Sweden)

    Wang W


    Full Text Available Wei Wang, Jianbin Li, Yingjie Zhang, Qian Shao, Min Xu, Tingyong Fan, Jinzhi Wang Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Shandong, People’s Republic of China Background and purpose: To investigate the definition of planning target volumes (PTVs based on four-dimensional computed tomography (4DCT compared with conventional PTV definition and PTV definition using asymmetrical margins for thoracic primary esophageal cancer. Materials and methods: Forty-three patients with esophageal cancer underwent 3DCT and 4DCT simulation scans during free breathing. The motions of primary tumors located in the proximal (group A, middle (group B, and distal (group C thoracic esophagus were obtained from the 4DCT scans. PTV3D was defined on 3DCT using the tumor motion measured based on 4DCT, PTV conventional (PTVconv was defined on 3DCT by adding a 1.0 cm margin to the clinical target volume, and PTV4D was defined as the union of the target volumes contoured on the ten phases of the 4DCT images. The centroid positions, volumetric differences, and dice similarity coefficients were evaluated for all PTVs. Results: The median centroid shifts between PTV3D and PTV4D and between PTVconv and PTV4D in all three dimensions were <0.3 cm for the three groups. The median size ratios of PTV4D to PTV3D were 0.80, 0.88, and 0.71, and PTV4D to PTVconv were 0.67, 0.73, and 0.76 (χ2=–3.18, –2.98, and –3.06; P=0.001, 0.003, and 0.002 for groups A, B, and C, respectively. The dice similarity coefficients were 0.87, 0.90, and 0.81 between PTV4D and PTV3D and 0.80, 0.84, and 0.83 between PTV4D and PTVconv (χ2=–3.18, –2.98, and –3.06; P=0.001, 0.003, and 0.002 for groups A, B, and C, respectively. The difference between the degree of inclusion of PTV4D in PTV3D and that of PTV4D in PTVconv was <2% for all groups. Compared with PTVconv, the amount of irradiated normal tissue

  7. [Definition of accurate planning target volume margins for esophageal cancer radiotherapy]. (United States)

    Lesueur, P; Servagi-Vernat, S


    More than 4000 cases of esophagus neoplasms are diagnosed every year in France. Radiotherapy, which can be delivered in preoperative or exclusive with a concomitant chemotherapy, plays a central role in treatment of esophagus cancer. Even if efficacy of radiotherapy no longer has to be proved, the prognosis of esophagus cancer remains unfortunately poor with a high recurrence rate. Toxicity of esophageal radiotherapy is correlated with the irradiation volume, and limits dose escalation and local control. Esophagus is a deep thoracic organ, which undergoes cardiac and respiratory motion, making the radiotherapy delivery more difficult and increasing the planning target volume margins. Definition of accurate planning target volume margins, taking into account the esophagus' intrafraction motion and set up margins is very important to be sure to cover the clinical target volume and restrains acute and late radiotoxicity. In this article, based on a review of the literature, we propose planning target volume margins adapted to esophageal radiotherapy. Copyright © 2016 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.

  8. Effect of the curing method and composite volume on marginal and internal adaptation of composite restoratives. (United States)

    Souza-Junior, Eduardo José; de Souza-Régis, Marcos Ribeiro; Alonso, Roberta Caroline Bruschi; de Freitas, Anderson Pinheiro; Sinhoreti, Mario Alexandre Coelho; Cunha, Leonardo Gonçalves


    The aim of the present study was to evaluate the influence of curing methods and composite volumes on the marginal and internal adaptation of composite restoratives. Two cavities with different volumes (Lower volume: 12.6 mm(3); Higher volume: 24.5 mm(3)) were prepared on the buccal surface of 60 bovine teeth and restored using Filtek Z250 in bulk filling. For each cavity, specimens were randomly assigned into three groups according to the curing method (n=10): 1) continuous light (CL: 27 seconds at 600 mW/cm(2)); 2) soft-start (SS: 10 seconds at 150 mW/cm(2)+24 seconds at 600 mW/cm(2)); and 3) pulse delay (PD: five seconds at 150 mW/cm(2)+three minutes with no light+25 seconds at 600 mW/cm(2)). The radiant exposure for all groups was 16 J/cm(2). Marginal adaptation was measured with the dye staining gap procedure, using Caries Detector. Outer margins were stained for five seconds and the gap percentage was determined using digital images on a computer measurement program (Image Tool). Then, specimens were sectioned in slices and stained for five seconds, and the internal gaps were measured using the same method. Data were submitted to two-way analysis of variance and Tukey test (pcuring method. For CL groups, restorations with higher volume showed higher marginal gap incidence than did the lower volume restorations. Additionally, the effect of the curing method depended on the volume. Regarding marginal adaptation, SS resulted in a significant reduction of gap formation, when compared to CL, for higher volume restorations. For lower volume restorations, there was no difference among the curing methods. For internal adaptation, the modulated curing methods SS and PD promoted a significant reduction of gap formation, when compared to CL, only for the lower volume restoration. Therefore, in similar conditions of the cavity configuration, the higher the volume of composite, the greater the gap formation. In addition, modulated curing methods (SS and PD) can improve

  9. Image-guided radiotherapy of bladder cancer: bladder volume variation and its relation to margins

    DEFF Research Database (Denmark)

    Muren, Ludvig; Redpath, Anthony Thomas; Lord, Hannah


    BACKGROUND AND PURPOSE: To control and account for bladder motion is a major challenge in radiotherapy (RT) of bladder cancer. This study investigates the relation between bladder volume variation and margins in conformal and image-guided RT (IGRT) for this disease. MATERIALS AND METHODS: The cor...

  10. Improvements on digital inline holographic PTV for 3D wall-bounded turbulent flow measurements (United States)

    Toloui, Mostafa; Mallery, Kevin; Hong, Jiarong


    Three-dimensional (3D) particle image velocimetry (PIV) and particle tracking velocimetry (PTV) provide the most comprehensive flow information for unraveling the physical phenomena in a wide range of fluid problems, from microfluidics to wall-bounded turbulent flows. Compared with other 3D PIV techniques, such as tomographic PIV and defocusing PIV, the digital inline holographic PTV (DIH-PTV) provides 3D flow measurement solution with high spatial resolution, low cost optical setup, and easy alignment and calibration. Despite these advantages, DIH-PTV suffers from major limitations including poor longitudinal resolution, human intervention (i.e. requirement for manually determined tuning parameters during tracer field reconstruction and extraction), limited tracer concentration, small sampling volume and expensive computations, limiting its broad use for 3D flow measurements. In this study, we present our latest developments on minimizing these challenges, which enables high-fidelity DIH-PTV implementation to larger sampling volumes with significantly higher particle seeding densities suitable for wall-bounded turbulent flow measurements. The improvements include: (1) adjustable window thresholding; (2) multi-pass 3D tracking; (3) automatic wall localization; and (4) continuity-based out-of-plane velocity component computation. The accuracy of the proposed DIH-PTV method is validated with conventional 2D PIV and double-view holographic PTV measurements in smooth-wall turbulent channel flow experiments. The capability of the technique in characterization of wall-bounded turbulence is further demonstrated through its application to flow measurements for smooth- and rough-wall turbulent channel flows. In these experiments, 3D velocity fields are measured within sampling volumes of 14.7  ×  50.0  ×  14.4 mm3 (covering the entire depth of the channel) with a velocity resolution of  presented DIH-PTV method and measurements highlight the

  11. Extracranial stereotactic radiotherapy: evaluation of PTV coverage and dose conformity. (United States)

    Hädinger, Ulrich; Thiele, Wibke; Wulf, Jörn


    During the past few years the concept of cranial stereotactic radiotherapy has been successfully extended to extracranial tumoral targets. In our department, hypofractionated treatment of tumours in lung, liver, abdomen, and pelvis is performed in the Stereotactic Body Frame (ELEKTA Instrument AB) since 1997. We present the evaluation of 63 consecutively treated targets (22 lung, 21 liver, 20 abdomen/pelvis) in 58 patients with respect to dose coverage of the planning target volume (PTV) as well as conformity of the dose distribution. The mean PTV coverage was found to be 96.3% +/- 2.3% (lung), 95.0% +/- 4.5% (liver), and 92.1% +/- 5.2% (abdomen/pelvis). For the so-called conformation number we obtained values of 0.73 +/- 0.09 (lung), 0.77 +/- 0.10 (liver), and 0.70 +/- 0.08 (abdomen/pelvis). The results show that highly conformal treatment techniques can be applied also in extracranial stereotactic radiotherapy. This is primarily due to the relatively simple geometrical shape of most of the targets. Especially lung and liver targets turned out to be approximately spherically/cylindrically shaped, so that the dose distribution can be easily tailored by rotational fields.

  12. Dosimetric Evaluation of Individualized Adaptive Motion Margins for Abdominal and Thoracic Tumors

    DEFF Research Database (Denmark)

    Poulsen, Per Rugaard; Cho, Byungchul; Keall, Paul

    the former ignores motion correlation along different axes the latter tends to overestimate the dosimetric consequences of random motion. The purpose of this study was to propose and investigate an individualized adaptive margin approach that accounts for motion correlation while still considering......, the smallest Dmin was 71%. The mean PTV volume was 7.6 cm3 for adaptive margins (4.3 mm, 1.6 mm, 1.0 mm margins) and 8.2 cm3 for standard margins (1.8 mm, 3.4 mm, 2.4 mm margins). Conclusions: A strategy for individualized adaptive margins that accounts for motion correlation was proposed. Compared to standard...... margins, the adaptive margins result in slightly smaller PTvs. and give fewer outliers with low minimum CTV dose....

  13. Changes in the planning target volume and liver volume dose based on the selected respiratory phase in respiratory-gated radiation therapy for a hepatocellular carcinoma (United States)

    Lee, Jae-Seung; Im, In-Chul; Kang, Su-Man; Goo, Eun-Hoe; Baek, Seong-Min


    The aim of this study was to quantitatively analyze the changes in the planning target volume (PTV) and liver volume dose based on the respiratory phase to identify the optimal respiratory phase for respiratory-gated radiation therapy for a hepatocellular carcinoma (HCC). Based on the standardized procedure for respiratory-gated radiation therapy, we performed a 4-dimensional computed tomography simulation for 0 ˜ 90%, 30 ˜ 70%, and 40 ˜ 60% respiratory phases to assess the respiratory stability (S R ) and the defined PTV i for each respiratory phase i. A treatment plan was established, and the changes in the PTV i and dose volume of the liver were quantitatively analyzed. Most patients (91.5%) passed the respiratory stability test (S R = 0.111 ± 0.015). With standardized respiration training exercises, we were able to minimize the overall systematic error caused by irregular respiration. Furthermore, a quantitative analysis to identify the optimal respiratory phase revealed that when a short respiratory phase (40 ˜ 60%) was used, the changes in the PTV were concentrated inside the center line; thus, we were able to obtain both a PTV margin accounting for respiration and a uniform radiation dose within the PTV.

  14. High fidelity digital inline holographic PTV for 3D flow measurements: from microfluidics to wall-bounded turbulence (United States)

    Hong, Jiarong; Toloui, Mostafa; Mallery, Kevin


    Three-dimensional PIV and PTV provides the most comprehensive flow information for unraveling the physical phenomena in a wide range of fluid problems, from microfluidics to wall-bounded turbulent flows. Compared with other commercialized 3D PIV techniques, such as tomographic PIV and defocusing PIV, the digital inline holographic PTV (namely DIH-PTV) provides 3D flow measurement solution with high spatial resolution, low cost optical setup, and easy alignment and calibration. Despite these advantages, DIH-PTV suffers from major limitations including poor longitudinal resolution, human intervention (i.e. requirement for manually determined tuning parameters during tracer field reconstruction and extraction), limited tracer concentration, small sampling volume and expensive computations, limiting its broad use for 3D flow measurements. Here we will report our latest work on improving DIH-PTV method through an integration of deconvolution algorithm, iterative removal method and GPU computation to overcome some of abovementioned limitations. We will also present the application of our DIH-PTV for measurements in the following sample cases: (i) flows in bio-filmed microchannel with 50-60 μm vector spacing within sampling volumes of 1 mm (streamwise) x 1 mm (wall-normal) x 1 mm (spanwise); (ii) turbulent flows over smooth and rough surfaces (1.1 mm vector spacing within 15 mm x 50 mm x 15 mm); (iii) 3D distribution and kinematics of inertial particles in turbulent air duct flow.

  15. Comparison of Tomo-PIV and 3D-PTV for microfluidic flows (United States)

    Kim, Hyoungsoo; Westerweel, Jerry; Elsinga, Gerrit E.


    Two 3D-3C velocimetry techniques for micro-scale measurements are compared: tomographic particle image velocimetry (Tomo-PIV) and 3D particle-tracking velocimetry (3D-PTV). Both methods are applied to experimental data from a confined shear-driven liquid droplet over a moving surface. The droplet has 200 μm height and 2 mm diameter. Micro 3D-PTV and Tomo-PIV are used to obtain the tracer particle distribution and the flow velocity field for the same set of images. It is shown that the reconstructed particle distributions are distinctly different, where Tomo-PIV returns a nearly uniform distribution over the height of the volume, as expected, and PTV reveals a clear peak in the particle distribution near the plane of focus. In Tomo-PIV, however, the reconstructed particle peak intensity decreases in proportion to the distance from the plane of focus. Due to the differences in particle distributions, the measured flow velocities are also different. In particular, we observe Tomo-PIV to be in closer agreement with mass conservation. Furthermore, the random noise level is found to increase with distance to the plane of focus at a higher rate for 3D-PTV as compared to Tomo-PIV. Thus, for a given noise threshold value, the latter method can measure reliably over a thicker volume.

  16. SU-E-J-35: Using CBCT as the Alternative Method of Assessing ITV Volume

    Energy Technology Data Exchange (ETDEWEB)

    Liao, Y; Turian, J; Templeton, A; Redler, G; Chu, J [Rush University Medical Center, Chicago, IL (United States)


    Purpose To study the accuracy of Internal Target Volumes (ITVs) created on cone beam CT (CBCT) by comparing the visible target volume on CBCT to volumes (GTV, ITV, and PTV) outlined on free breathing (FB) CT and 4DCT. Methods A Quasar Cylindrical Motion Phantom with a 3cm diameter ball (14.14 cc) embedded within a cork insert was set up to simulate respiratory motion with a period of 4 seconds and amplitude of 2cm superioinferiorly and 1cm anterioposteriorly. FBCT and 4DCT images were acquired. A PTV-4D was created on the 4DCT by applying a uniform margin of 5mm to the ITV-CT. PTV-FB was created by applying a margin of the motion range plus 5mm, i.e. total of 1.5cm laterally and 2.5cm superioinferiorly to the GTV outlined on the FBCT. A dynamic conformal arc was planned to treat the PTV-FB with 1mm margin. A CBCT was acquired before the treatment, on which the target was delineated. During the treatment, the position of the target was monitored using the EPID in cine mode. Results ITV-CBCT and ITV-CT were measured to be 56.6 and 62.7cc, respectively, with a Dice Coefficient (DC) of 0.94 and disagreement in center of mass (COM) of 0.59 mm. On the other hand, GTV-FB was 11.47cc, 19% less than the known volume of the ball. PTV-FB and PTV-4D were 149 and 116 cc, with a DC of 0.71. Part of the ITV-CT was not enclosed by the PTV-FB despite the large margin. The cine EPID images have confirmed geometrical misses of the target. Similar under-coverage was observed in one clinical case and captured by the CBCT, where the implanted fiducials moved outside PTV-FB. Conclusion ITV-CBCT is in good agreement with ITV-CT. When 4DCT was not available, CBCT can be an effective alternative in determining and verifying the PTV margin.

  17. Radical prostatectomy and positive surgical margins: tumor volume and Gleason score predicts cancer outcome

    Energy Technology Data Exchange (ETDEWEB)

    La Roca, Ricardo L.R. Felts de, E-mail: [Hospital do Cancer A.C. Camargo, Sao Paulo, SP (Brazil); Fonseca, Francisco Paula da, E-mail: [Hospital do Cancer A.C. Camargo, Sao Paulo, SP (Brazil). Divisao de Urologia. Dept. de Cirurgia Pelvica; Cunha, Isabela Werneck da; Bezerra, Stephania Martins, E-mail:, E-mail: [Hospital do Cancer A.C. Camargo, Sao Paulo, SP (Brazil). Dept. de Patologia


    Introduction: positive surgical margins (PSMs) are common adverse factors to predict the outcome of a patient submitted to radical prostatectomy (PR). However, not all of these men will follow with biochemical (BCR) or clinical (CR) recurrence. Relationship between PSMs with these recurrent events has to be correlated with other clinicopathological findings in order to recognize more aggressive tumors in order to recommend complementary treatment to these selected patients. Materials and methods: we retrospectively reviewed the outcome of 228 patients submitted to open retropubic RP between March 1991 and June 2008, where 161 had and 67 did not have PSMs. Minimum follow-up time was considered 2 years after surgery. BCR was considered when PSA {>=} 0.2 ng/ml. CR was determined when clinical evidence of tumor appeared. Chi-square test was used to correlate clinical and pathologic variables with PSMs. The estimated 5-year risk of BCR and CR in presence of PSMs was determined using the Kaplan-Meier method and compared to log-rank tests. Results: from the total of 228 patients, 161 (71%) had PSMs, while 67 (29%) had negative surgical margins (NSMs). Prostatic circumferential margin was the most common (43.4%) site. Univariate analysis showed statistically significant (p < 0.001) associations between the presence of PSMs and BCR, but not with CR (p = 0.06). Among 161 patients with PSMs, 61 (37.8%) presented BCR, while 100 (62.8%) did not. Predicting progression-free survival for 5 years, BCR was correlated with pathological stage; Gleason score; pre-treatment PSA; tumor volume in specimen; capsular and perineural invasion; presence and number of PSMs. RC correlated only with angiolymphatic invasion and Gleason score. Considering univariate analyses the clinicopathological factors predicting BCR for 5 years, results statistically significant links with prostate weight; pre-treatment PSA; Gleason score; pathological stage; tumor volume; PSMs; capsular and perineural

  18. Target margins in radiotherapy of prostate cancer. (United States)

    Yartsev, Slav; Bauman, Glenn


    We reviewed the literature on the use of margins in radiotherapy of patients with prostate cancer, focusing on different options for image guidance (IG) and technical issues. The search in PubMed database was limited to include studies that involved external beam radiotherapy of the intact prostate. Post-prostatectomy studies, brachytherapy and particle therapy were excluded. Each article was characterized according to the IG strategy used: positioning on external marks using room lasers, bone anatomy and soft tissue match, usage of fiducial markers, electromagnetic tracking and adapted delivery. A lack of uniformity in margin selection among institutions was evident from the review. In general, introduction of pre- and in-treatment IG was associated with smaller planning target volume (PTV) margins, but there was a lack of definitive experimental/clinical studies providing robust information on selection of exact PTV values. In addition, there is a lack of comparative research regarding the cost-benefit ratio of the different strategies: insertion of fiducial markers or electromagnetic transponders facilitates prostate gland localization but at a price of invasive procedure; frequent pre-treatment imaging increases patient in-room time, dose and labour; online plan adaptation should improve radiation delivery accuracy but requires fast and precise computation. Finally, optimal protocols for quality assurance procedures need to be established.

  19. Dense velocity reconstruction from tomographic PTV with material derivatives (United States)

    Schneiders, Jan F. G.; Scarano, Fulvio


    A method is proposed to reconstruct the instantaneous velocity field from time-resolved volumetric particle tracking velocimetry (PTV, e.g., 3D-PTV, tomographic PTV and Shake-the-Box), employing both the instantaneous velocity and the velocity material derivative of the sparse tracer particles. The constraint to the measured temporal derivative of the PTV particle tracks improves the consistency of the reconstructed velocity field. The method is christened as pouring time into space, as it leverages temporal information to increase the spatial resolution of volumetric PTV measurements. This approach becomes relevant in cases where the spatial resolution is limited by the seeding concentration. The method solves an optimization problem to find the vorticity and velocity fields that minimize a cost function, which includes next to instantaneous velocity, also the velocity material derivative. The velocity and its material derivative are related through the vorticity transport equation, and the cost function is minimized using the limited-memory Broyden-Fletcher-Goldfarb-Shanno (L-BFGS) algorithm. The procedure is assessed numerically with a simulated PTV experiment in a turbulent boundary layer from a direct numerical simulation (DNS). The experimental validation considers a tomographic particle image velocimetry (PIV) experiment in a similar turbulent boundary layer and the additional case of a jet flow. The proposed technique (`vortex-in-cell plus', VIC+) is compared to tomographic PIV analysis (3D iterative cross-correlation), PTV interpolation methods (linear and adaptive Gaussian windowing) and to vortex-in-cell (VIC) interpolation without the material derivative. A visible increase in resolved details in the turbulent structures is obtained with the VIC+ approach, both in numerical simulations and experiments. This results in a more accurate determination of the turbulent stresses distribution in turbulent boundary layer investigations. Data from a jet

  20. Network Awareness in P2P-TV Applications (United States)

    Traverso, Stefano; Leonardi, Emilio; Mellia, Marco; Meo, Michela

    The increasing popularity of applications for video-streaming based on P2P paradigm (P2P-TV) is raising the interest of both broadcasters and network operators. The former see a promising technology to reduce the cost of streaming content over the Internet, while offering a world-wide service. The latter instead fear that the traffic offered by these applications can grow without control, affecting other services, and possibly causing network congestion and collapse. The “Network-Aware P2P-TV Application over Wise Networks” FP7 project aims at studying and developing a novel P2P-TV application offering the chance to broadcast high definition video to broadcasters and to carefully manage the traffic offered by peers to the network, therefore avoiding worries to Internet providers about network overload. In such context, we design a simulator to evaluate performance of different P2P-TV solutions, to compare them both considering end-users’ and network providers’ perspectives, such as quality of service perceived by subscribers and link utilization. In this paper, we provide some results that show how effective can be a network aware P2P-TV system.

  1. The optimization of intensity modulated radiotherapy in cases where the planning target volume extends into the build-up region

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, T B; Hoole, A C F; Thomas, S J [Medical Physics Department, Addenbrooke' s Hospital, Hills Road, Cambridge CB2 0QQ (United Kingdom); Burnet, N G [Department of Oncology, University of Cambridge, Oncology Centre (Box 193), Addenbrooke' s Hospital, Hills Road, Cambridge, CB2 0QQ (United Kingdom)], E-mail:


    A common clinical problem in IMRT, especially when treating head and neck cases, is that the clinical target volume (CTV) stops short of the skin surface, whilst the margin for geometric uncertainties may take the planning target volume (PTV) to the skin surface or beyond. In these cases, optimization leads to over-dosing of the skin, unless the planner resorts to procedural tricks to avoid this, such as the use of pretend bolus or reduction of the PTV followed by adding 'flash' after optimization. This paper describes a method of avoiding the need for these tricks by using a multiple-isocentre CTV-based objective function. This enables plans to be produced that will give good coverage of the CTV for all the geometrical uncertainties that would have been covered by the PTV without causing the problem of over-dosing the skin. Eight isocentre shifts, equally distributed on the surface of a sphere with a radius equal to the CTV-PTV margin, are shown to be adequate for the optimization process. The resulting fluence maps are much simpler than those resulting from PTV optimization and will therefore be simpler to deliver. The method also permits better sparing of organs at risk such as the spinal cord.

  2. The optimization of intensity modulated radiotherapy in cases where the planning target volume extends into the build-up region (United States)

    Nguyen, T. B.; Hoole, A. C. F.; Burnet, N. G.; Thomas, S. J.


    A common clinical problem in IMRT, especially when treating head and neck cases, is that the clinical target volume (CTV) stops short of the skin surface, whilst the margin for geometric uncertainties may take the planning target volume (PTV) to the skin surface or beyond. In these cases, optimization leads to over-dosing of the skin, unless the planner resorts to procedural tricks to avoid this, such as the use of pretend bolus or reduction of the PTV followed by adding 'flash' after optimization. This paper describes a method of avoiding the need for these tricks by using a multiple-isocentre CTV-based objective function. This enables plans to be produced that will give good coverage of the CTV for all the geometrical uncertainties that would have been covered by the PTV without causing the problem of over-dosing the skin. Eight isocentre shifts, equally distributed on the surface of a sphere with a radius equal to the CTV-PTV margin, are shown to be adequate for the optimization process. The resulting fluence maps are much simpler than those resulting from PTV optimization and will therefore be simpler to deliver. The method also permits better sparing of organs at risk such as the spinal cord.

  3. SU-E-T-492: Influence of Clipping PTV in Build-Up Region On IMRT Plan Quality and Deliverability

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, S; Manigandan, D; Sahai, P; Biswas, A; Subramani, V; Chander, S; Julkha, P; Rath, G [Fortis Hospital, Mohali, Punjab (India)


    Purpose: To study the influence of clipping PTV from body contour on plan quality and deliverability in build-up region for superficial target. Methods: Five previously treated patients of post-operative carcinoma of parotid were re-planned for IMRT (6MV X-rays, sliding window technique, five fields and 60Gy/30 fractions) using eclipse treatment planning system (TPS) by keeping dose volume constraints and all other parameters constant, only PTV was clipped from body contour by 0mm, 1mm, 2mm and 3mm respectively. Planned fluence was transferred to previously scanned solid water phantom by placing I’matriXX array at 0.5cm depth (2mm slab+3mm inherent). Fluence was delivered by Varian CL2300C/D linac at 99.5cm source to detector distance. Measured fluence was compared with TPS dose plane using 2D gamma evaluation using 3%/3mm DTA criteria. Total MU (monitor unit) required to deliver a plan was also noted. For plan quality, PTV, maximum-dose, minimum-dose, coverage index (CI=PTV volume covered by prescription dose/PTV) and heterogeneity index HI=D5/D95 were analyzed using dose volume histogram (DVH). Results: The Result of gamma function analysis for I’matriXX and TPS were 97.63±1.79%, 97.48±0.99, 98.08±0.89% and 98.01±0.78% at 0.5cm build-up depth for 0, 1, 2 and 3mm PTV clipping, respectively. I’matriXX measured dose was higher compared to TPS. Total MU required for delivering a plan were 552±61, 503±47, 436±24 and 407±22. Maximum-dose to PTV was 6635.80±62.01cGy, 6635.80±40.60cGy, 6608.43±51.07cGy and 6564.20±28.51cGy. Similarly, minimum-dose to PTV was 3306.23±458.56cGy, 3546.57±721.01cGy, 4591.43±298.81cGy and 4861.90±412.40cGy. CI was 0.9347±0.020, 0.9398±0.021, 0.9448±0.022 and 0.9481±0.021. Similarly, HI was 1.089±0.015, 1.084±0.014, 1.078±0.009 and 1.074±0.008 for 0, 1, 2 and 3mm PTV clipping, respectively. Conclusion: Gamma function analysis resulted in almost similar results. However, I’matriXX was overestimating the dose

  4. Conformity analysis to demonstrate reproducibility of target volumes for Margin-Intense Stereotactic Radiotherapy for borderline-resectable pancreatic cancer. (United States)

    Holyoake, Daniel L P; Robinson, Maxwell; Grose, Derek; McIntosh, David; Sebag-Montefiore, David; Radhakrishna, Ganesh; Patel, Neel; Partridge, Mike; Mukherjee, Somnath; Hawkins, Maria A


    Margin-directed neoadjuvant radiotherapy for borderline-resectable pancreatic cancer (BRPC) aims to facilitate clear surgical margins. A systematic method was developed for definition of a boost target volume prior to a formal phase-I study. Reference structures were defined by two oncologists and one radiologist, target structures were submitted by eight oncologist investigators and compared using conformity indices. Resultant risk of duodenal bleed (NTCP) was modelled. For GTV, reference volume was 2.1cm(3) and investigator mean was 6.03cm(3) (95% CI 3.92-8.13cm(3)), for boost volume 1.1cm(3) and 1.25cm(3) (1.02-1.48cm(3)). Mean Dice conformity coefficient for GTV was 0.47 (0.38-0.56), and for boost volume was significantly higher at 0.61 (0.52-0.70, p=0.01). Discordance index (DI) for GTV was 0.65 (0.56-0.75) and for boost volume was significantly lower at 0.39 (0.28-0.49, p=0.001). NTCP using reference contours was 2.95%, with mean for investigator contour plans 3.93% (3.63-4.22%). Correlations were seen between NTCP and GTV volume (p=0.02) and NTCP and DI (correlation coefficient 0.83 (0.29-0.97), p=0.01). Better conformity with reference was shown for boost volume compared with GTV. Investigator GTV volumes were larger than reference, had higher DI scores and modelled toxicity risk. A consistent method of target structure definition for margin-directed pancreatic radiotherapy is demonstrated. Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

  5. Optimizing Collimator Margins for Isotoxically Dose-Escalated Conformal Radiation Therapy of Non-Small Cell Lung Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Warren, Samantha, E-mail: [Department of Oncology, Gray Institute of Radiation Oncology and Biology, University of Oxford, Oxford (United Kingdom); Oxford Cancer Centre, Oxford University Hospitals, Oxford (United Kingdom); Panettieri, Vanessa [William Buckland Radiotherapy Centre, Alfred Hospital, Commercial Road, Melbourne (Australia); Panakis, Niki; Bates, Nicholas [Oxford Cancer Centre, Oxford University Hospitals, Oxford (United Kingdom); Lester, Jason F. [Velindre Cancer Centre, Velindre Road, Whitchurch, Cardiff (United Kingdom); Jain, Pooja [Clatterbridge Cancer Centre, Clatterbridge Road, Wirral (United Kingdom); Landau, David B. [Department of Radiotherapy, Guy' s and St. Thomas' NHS Foundation Trust, London (United Kingdom); Nahum, Alan E.; Mayles, W. Philip M. [Clatterbridge Cancer Centre, Clatterbridge Road, Wirral (United Kingdom); Fenwick, John D. [Department of Oncology, Gray Institute of Radiation Oncology and Biology, University of Oxford, Oxford (United Kingdom); Oxford Cancer Centre, Oxford University Hospitals, Oxford (United Kingdom)


    Purpose: Isotoxic dose escalation schedules such as IDEAL-CRT [isotoxic dose escalation and acceleration in lung cancer chemoradiation therapy] (ISRCTN12155469) individualize doses prescribed to lung tumors, generating a fixed modeled risk of radiation pneumonitis. Because the beam penumbra is broadened in lung, the choice of collimator margin is an important element of the optimization of isotoxic conformal radiation therapy for lung cancer. Methods and Materials: Twelve patients with stage I-III non-small cell lung cancer (NSCLC) were replanned retrospectively using a range of collimator margins. For each plan, the prescribed dose was calculated according to the IDEAL-CRT isotoxic prescription method, and the absolute dose (D{sub 99}) delivered to 99% of the planning target volume (PTV) was determined. Results: Reducing the multileaf collimator margin from the widely used 7 mm to a value of 2 mm produced gains of 2.1 to 15.6 Gy in absolute PTV D{sub 99}, with a mean gain ± 1 standard error of the mean of 6.2 ± 1.1 Gy (2-sided P<.001). Conclusions: For NSCLC patients treated with conformal radiation therapy and an isotoxic dose prescription, absolute doses in the PTV may be increased by using smaller collimator margins, reductions in relative coverage being offset by increases in prescribed dose.

  6. Large-scale volumetric pressure from tomographic PTV with HFSB tracers (United States)

    Schneiders, Jan F. G.; Caridi, Giuseppe C. A.; Sciacchitano, Andrea; Scarano, Fulvio


    The instantaneous volumetric pressure in the near-wake of a truncated cylinder is measured by use of tomographic particle tracking velocimetry (PTV) using helium-filled soap bubbles (HFSB) as tracers. The measurement volume is several orders of magnitude larger than that reported in tomographic experiments dealing with pressure from particle image velocimetry (PIV). The near-wake of a truncated cylinder installed on a flat plate ( Re D = 3.5 × 104) features both wall-bounded turbulence and large-scale unsteady flow separation. The instantaneous pressure is calculated from the time-resolved 3D velocity distribution by invoking the momentum equation. The experiments are conducted simultaneously with surface pressure measurements intended for validation of the technique. The study shows that time-averaged pressure and root-mean-squared pressure fluctuations can be accurately measured both in the fluid domain and at the solid surface by large-scale tomographic PTV with HFSB as tracers, with significant reduction in manufacturing complexity for the wind-tunnel model and circumventing the need to install pressure taps or transducers. The measurement over a large volume eases the extension toward the free-stream regime, providing a reliable boundary condition for the solution of the Poisson equation for pressure. The work demonstrates, in the case of the flow past a truncated cylinder, the use of HFSB tracer particles for pressure measurement in air flows in a measurement volume that is two orders of magnitude larger than that of conventional tomographic PIV.

  7. Investigation of optimal beam margins for stereotactic radiotherapy of lung-cancer using Monte Carlo dose calculations

    Energy Technology Data Exchange (ETDEWEB)

    Jin, L; Wang, L; Li, J; Luo, W; Feigenberg, S J; Ma, C-M [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111 (United States)


    This work investigated the selection of beam margins in lung-cancer stereotactic body radiotherapy (SBRT) with 6 MV photon beams. Monte Carlo dose calculations were used to systematically and quantitatively study the dosimetric effects of beam margins for different lung densities (0.1, 0.15, 0.25, 0.35 and 0.5 g cm{sup -3}), planning target volumes (PTVs) (14.4, 22.1 and 55.3 cm{sup 3}) and numbers of beam angles (three, six and seven) in lung-cancer SBRT in order to search for optimal beam margins for various clinical situations. First, a large number of treatment plans were generated in a commercial treatment planning system, and then recalculated using Monte Carlo simulations. All the plans were normalized to ensure that 95% of the PTV at least receives the prescription dose and compared quantitatively. Based on these plans, the relationships between the beam margin and quantities such as the lung toxicity (quantified by V{sub 20}, the percentage volume of the two lungs receiving at least 20 Gy) and the maximum target (PTV) dose were established for different PTVs and lung densities. The impact of the number of beam angles on the relationship between V{sub 20} and the beam margin was assessed. Quantitative information about optimal beam margins for lung-cancer SBRT was obtained for clinical applications.

  8. Aeromechanics and Vehicle Configuration Demonstrations. Volume 3: A Hybrid Probabilistic Method for Estimate Design Margin (United States)


    Employs empiricism • Employs experience/competency • Provides probabilistic estimating results. The first three items of this list deal with the...this list address particular inputs to the margin estimating technique. The first is that methods to estimate margin should employ empiricism . This can...experience becomes more critical to the success of the estimation if the methodology employed utilizes a smaller amount of empiricism . [1] The

  9. Characteristics of seeding particles for PIV/PTV analysis (United States)

    Hadad, Tal; Liberzon, Alexander; Bernhaim, Anne; Gurka, Roi


    PIV and PTV are non-intrusive state-of-the-art techniques widely used for flow measurements. Seeding particles are required to be used as tracers to the flow. The accuracy of the velocity measurements is limited by the ability of the tracer particles to adequately follow the instantaneous motion of the continuous phase. In order to follow the flow effectively, the particles should satisfy numerous requirements: size, sphericity, density, high refractive index, concentration and chemical inert. Since seeding particles for liquids are commonly polymer-based particles we probe the influence of their surface coating on the results obtained from optical measurements. Using a canonical lid-driven cavity flow we measured the velocity field using PIV and PTV and compared the results (velocity and acceleration) obtained with the same particles with and without chemical treatment of surfactants. Probability density functions of the results using particles before and after treatment are compared statistically utilizing the two-sample Kolmogorov-Smirnov tests. Although the mean values exhibit similar trends, fluctuations and velocity derivatives show some discrepancy in respect to the chemical treatment. The obtained results show a variance of up to 5% between the values obtained for using washed and un-washed particles, for both PIV and PTV experiments with some influence related to the size of the particles.

  10. SU-E-T-642: PTV Is the Voxel-Wise Worst-Case of CTV in Prostate Photon Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Harrington, D; Schild, S; Wong, W; Vora, S; Liu, W [Mayo Clinic Arizona, Phoenix, AZ (United States)


    Purpose: To examine the adequacy of the planning target volume (PTV) dose distribution as the worst-case representation of clinical target volume (CTV) dose distribution in prostate volumetric-modulated arc therapy (VMAT) plans. Methods: Ten intact prostate cancer cases treated by VMAT at our institution were randomly selected. Isocenter was shifted in the three cardinal directions by a displacement equal to the PTV expansion on the CTV (±3 mm) for a total of six shifted plans per original plan. Rotationally-perturbed plans were generated with a couch rotation of ±1° to simulate patient yaw. The eight perturbed dose distributions were recalculated in the treatment planning system using the same, fixed fluence map as the original plan. The voxel-wise worst-case CTV dose distribution was constructed from the minimum value per voxel from the eight perturbed doses. The resulting dose volume histograms (DVH) were evaluated for statistical correlation between the worst-case CTV and nominal PTV dose distributions based on D95% by Wilcoxon signed-rank test with significance level p ≤ 0.05. Results: Inspection demonstrates the PTV DVH in the nominal dose distribution is bounded by the CTV DVH in the worst-case dose distribution. Comparison of D95% for the two dose distributions by Wilcoxon signed-rank test gives p = 0.131. Therefore the null hypothesis cannot be rejected since the difference in median values is not statistically significant. Conclusion: The assumption that the nominal dose distribution for PTV represents the worst-case dose distribution for CTV appears valid for the ten plans under examination. Although the worst-case dose distribution is unphysical since the dose per voxel is chosen independently, it serves as a lower bound for the possible CTV coverage. Furthermore, this is consistent with the unphysical nature of the PTV. Minor discrepancies between the two dose distributions are expected since the dose cloud is not strictly static. Funding Support

  11. Comparison between target margins derived from 4DCT scans and real-time tumor motion tracking: Insights from lung tumor patients treated with robotic radiosurgery

    Energy Technology Data Exchange (ETDEWEB)

    Descovich, Martina, E-mail:; McGuinness, Christopher; Kannarunimit, Danita; Chen, Josephine; Pinnaduwage, Dilini; Pouliot, Jean; Kased, Norbert; Gottschalk, Alexander R.; Yom, Sue S. [UCSF Department of Radiation Oncology, San Francisco, California 94115 (United States)


    Purpose: A unique capability of the CyberKnife system is dynamic target tracking. However, not all patients are eligible for this approach. Rather, their tumors are tracked statically using the vertebral column for alignment. When using static tracking, the internal target volume (ITV) is delineated on the four-dimensional (4D) CT scan and an additional margin is added to account for setup uncertainty [planning target volume (PTV)]. Treatment margins are difficult to estimate due to unpredictable variations in tumor motion and respiratory pattern during the course of treatment. The inability to track the target and detect changes in respiratory characteristics might result in geographic misses and local tumor recurrences. The purpose of this study is to develop a method to evaluate the adequacy of ITV-to-PTV margins for patients treated in this manner. Methods: Data from 24 patients with lesions in the upper lobe (n = 12), middle lobe (n = 3), and lower lobe (n = 9) were included in this study. Each patient was treated with dynamic tracking and underwent 4DCT scanning at the time of simulation. Data including the 3D coordinates of the target over the course of treatment were extracted from the treatment log files and used to determine actual target motion in the superior–inferior (S–I), anterior–posterior (A–P), and left–right (L–R) directions. Different approaches were used to calculate anisotropic and isotropic margins, assuming that the tumor moves as a rigid body. Anisotropic margins were calculated by separating target motion in the three anatomical directions, and a uniform margin was calculated by shifting the gross tumor volume contours in the 3D space and by computing the percentage of overlap with the PTV. The analysis was validated by means of a theoretical formulation. Results: The three methods provided consistent results. A uniform margin of 4.5 mm around the ITV was necessary to assure 95% target coverage for 95% of the fractions included

  12. Recommendations on the use of marginal base course materials in low volume roads in South Africa

    CSIR Research Space (South Africa)

    Paige-Green, P


    Full Text Available have required intermittent maintenance during their lives, they have clearly shown that current materials standards may be too conservative for affordable low volume roads. The study has shown that good drainage and construction quality are the primary...

  13. Sparing Healthy Tissue and Increasing Tumor Dose Using Bayesian Modeling of Geometric Uncertainties for Planning Target Volume Personalization

    Energy Technology Data Exchange (ETDEWEB)

    Herschtal, Alan, E-mail: [Department of Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, Melbourne (Australia); Faculty of Health, Arts and Design, Swinburne University of Technology, Melbourne (Australia); Te Marvelde, Luc [Department of Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, Melbourne (Australia); Mengersen, Kerrie [School of Mathematical Sciences, Science and Engineering Faculty, Queensland University of Technology, Brisbane (Australia); Foroudi, Farshad [Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne (Australia); The Sir Peter MacCallum Department of Oncology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne (Australia); Eade, Thomas [Northern Sydney Cancer Centre, Radiation Oncology Department, Royal North Shore Hospital, St. Leonards, Sydney (Australia); Northern Clinical School, University of Sydney (Australia); Pham, Daniel [Department of Radiation Therapy, Peter MacCallum Cancer Centre, Melbourne (Australia); Caine, Hannah [Northern Sydney Cancer Centre, Radiation Oncology Department, Royal North Shore Hospital, St. Leonards, Sydney (Australia); Kron, Tomas [The Sir Peter MacCallum Department of Oncology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne (Australia); Department of Physical Sciences, Peter MacCallum Cancer Centre, Melbourne (Australia)


    Objective: To develop a mathematical tool that can update a patient's planning target volume (PTV) partway through a course of radiation therapy to more precisely target the tumor for the remainder of treatment and reduce dose to surrounding healthy tissue. Methods and Materials: Daily on-board imaging was used to collect large datasets of displacements for patients undergoing external beam radiation therapy for solid tumors. Bayesian statistical modeling of these geometric uncertainties was used to optimally trade off between displacement data collected from previously treated patients and the progressively accumulating data from a patient currently partway through treatment, to optimally predict future displacements for that patient. These predictions were used to update the PTV position and margin width for the remainder of treatment, such that the clinical target volume (CTV) was more precisely targeted. Results: Software simulation of dose to CTV and normal tissue for 2 real prostate displacement datasets consisting of 146 and 290 patients treated with a minimum of 30 fractions each showed that re-evaluating the PTV position and margin width after 8 treatment fractions reduced healthy tissue dose by 19% and 17%, respectively, while maintaining CTV dose. Conclusion: Incorporating patient-specific displacement patterns from early in a course of treatment allows PTV adaptation for the remainder of treatment. This substantially reduces the dose to healthy tissues and thus can reduce radiation therapy–induced toxicities, improving patient outcomes.

  14. Accurate Localization of Aneurysm Neck Margins in Clipping of a Carotid Cave Aneurysm Using Intraoperative Dual-Volume 3-Dimensional Volume-Rendering Rotational Angiography. (United States)

    Huang, Chih-Ta; Hsu, Szu-Kai; Su, I-Chang


    Full visualization of the aneurysm neck is usually impossible in a classical pterional craniotomy when a paraclinoid aneurysm is located on the opposite side of the internal carotid artery. Optic nerve (ON) retraction is required for better aneurysmal exposure, but ON injuries may occur. In a case of a 70-year-old female harboring a carotid cave aneurysm, we introduced a new method to delineate better the margins of the aneurysm neck by using intraoperative 3-dimensional (3D) rotational angiography (RA) with dual-volume reconstruction. After complete exposure of the aneurysm, we placed a straight clip adjacent to the aneurysm for localization purposes and performed 3D-RA to locate the distal end of the aneurysm neck relative to the localization clip. With a better anatomic understanding of the neck position, we were able to reduce ON retraction and position the clip across the aneurysm neck more precisely. With the advantage of a hybrid operating room, we introduced a novel technique to define the margins of the obscured aneurysm neck more clearly by obtaining a 3D-RA dual-volume reconstruction image to locate the aneurysm neck relative to a localization clip. This technique facilitates the clipping procedure and also reduces the risk related to ON retraction during surgical exposure of a paraclinoid aneurysm. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Optimization of leaf margins for lung stereotactic body radiotherapy using a flattening filter-free beam

    Energy Technology Data Exchange (ETDEWEB)

    Wakai, Nobuhide, E-mail: [Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan and Department of Radiation Oncology, Nara Medical University, Kashihara, Nara 634-8522 (Japan); Sumida, Iori; Otani, Yuki; Suzuki, Osamu; Seo, Yuji; Isohashi, Fumiaki; Yoshioka, Yasuo; Ogawa, Kazuhiko [Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871 (Japan); Hasegawa, Masatoshi [Department of Radiation Oncology, Nara Medical University, Kashihara, Nara 634-8522 (Japan)


    Purpose: The authors sought to determine the optimal collimator leaf margins which minimize normal tissue dose while achieving high conformity and to evaluate differences between the use of a flattening filter-free (FFF) beam and a flattening-filtered (FF) beam. Methods: Sixteen lung cancer patients scheduled for stereotactic body radiotherapy underwent treatment planning for a 7 MV FFF and a 6 MV FF beams to the planning target volume (PTV) with a range of leaf margins (−3 to 3 mm). Forty grays per four fractions were prescribed as a PTV D95. For PTV, the heterogeneity index (HI), conformity index, modified gradient index (GI), defined as the 50% isodose volume divided by target volume, maximum dose (Dmax), and mean dose (Dmean) were calculated. Mean lung dose (MLD), V20 Gy, and V5 Gy for the lung (defined as the volumes of lung receiving at least 20 and 5 Gy), mean heart dose, and Dmax to the spinal cord were measured as doses to organs at risk (OARs). Paired t-tests were used for statistical analysis. Results: HI was inversely related to changes in leaf margin. Conformity index and modified GI initially decreased as leaf margin width increased. After reaching a minimum, the two values then increased as leaf margin increased (“V” shape). The optimal leaf margins for conformity index and modified GI were −1.1 ± 0.3 mm (mean ± 1 SD) and −0.2 ± 0.9 mm, respectively, for 7 MV FFF compared to −1.0 ± 0.4 and −0.3 ± 0.9 mm, respectively, for 6 MV FF. Dmax and Dmean for 7 MV FFF were higher than those for 6 MV FF by 3.6% and 1.7%, respectively. There was a positive correlation between the ratios of HI, Dmax, and Dmean for 7 MV FFF to those for 6 MV FF and PTV size (R = 0.767, 0.809, and 0.643, respectively). The differences in MLD, V20 Gy, and V5 Gy for lung between FFF and FF beams were negligible. The optimal leaf margins for MLD, V20 Gy, and V5 Gy for lung were −0.9 ± 0.6, −1.1 ± 0.8, and −2.1 ± 1.2 mm, respectively, for 7 MV FFF compared

  16. Prostate cancer treated with image-guided helical TomoTherapy {sup registered} and image-guided LINAC-IMRT. Correlation between high-dose bladder volume, margin reduction, and genitourinary toxicity

    Energy Technology Data Exchange (ETDEWEB)

    Drozdz, Sonia; Wendt, Thomas G. [University Hospital Jena, Friedrich-Schiller-University Jena, Department of Radiation Oncology, Jena (Germany); Schwedas, Michael; Salz, Henning [University Hospital Jena, Friedrich-Schiller-University Jena, Department of Radiation Oncology, Section of Medical Physics, Jena (Germany); Foller, Susan [University Hospital Jena, Friedrich-Schiller-University Jena, Department of Urology, Jena (Germany)


    We compared different image-guidance (IG) strategies for prostate cancer with high-precision IG intensity-modulated radiation therapy (IMRT) using TomoTherapy {sup registered} (Accuray Inc., Madison, WI, USA) and linear accelerator (LINAC)-IMRT and their impact on planning target volume (PTV) margin reduction. Follow-up data showed reduced bladder toxicity in TomoTherapy patients compared to LINAC-IMRT. The purpose of this study was to quantify whether the treatment delivery technique and decreased margins affect reductions in bladder toxicity. Setup corrections from 30 patients treated with helical TomoTherapy and 30 treated with a LINAC were analyzed. These data were used to simulate three IG protocols based on setup error correction and a limited number of imaging sessions. For all patients, gastrointestinal (GI) and genitourinary (GU) toxicity was documented and correlated with the treatment delivery technique. For fiducial marker (FM)-based RT, a margin reduction of up to 3.1, 3.0, and 4.8 mm in the left-right (LR), superior-inferior (SI), and anterior-posterior (AP) directions, respectively, could be achieved with calculation of a setup correction from the first three fractions and IG every second day. Although the bladder volume was treated with mean doses of 35 Gy in the TomoTherapy group vs. 22 Gy in the LINAC group, we observed less GU toxicity after TomoTherapy. Intraprostate FMs allow for small safety margins, help decrease imaging frequency after setup correction, and minimize the dose to bladder and rectum, resulting in lower GU toxicity. In addition, IMRT delivered with TomoTherapy helps to avoid hotspots in the bladder neck, a critical anatomic structure associated with post-RT urinary toxicity. (orig.) [German] Wir haben im Rahmen der Prostatakarzinombehandlung verschiedene bildgefuehrte (IG) Strategien der hochpraezisen intensitaetsmodulierten Radiotherapie (IMRT) unter Einsatz der Tomotherapie (TomoTherapy {sup registered}, Accuray Inc., Madison

  17. Beyond the margin recipe: the probability of correct target dosage and tumor control in the presence of a dose limiting structure (United States)

    Witte, Marnix G.; Sonke, Jan-Jakob; Siebers, Jeffrey; Deasy, Joseph O.; van Herk, Marcel


    In the past, hypothetical spherical target volumes and ideally conformal dose distributions were analyzed to establish the safety of planning target volume (PTV) margins. In this work we extended these models to estimate how alternative methods of shaping dose distributions could lead to clinical improvements. Based on a spherical clinical target volume (CTV) and Gaussian distributions of systematic and random geometrical uncertainties, idealized 3D dose distributions were optimized to exhibit specific stochastic properties. A nearby spherical organ at risk (OAR) was introduced to explore the benefit of non-spherical dose distributions. Optimizing for the same minimum dose safety criterion as implied by the generally accepted use of a PTV, the extent of the high dose region in one direction could be reduced by half provided that dose in other directions is sufficiently compensated. Further reduction of this unilateral dosimetric margin decreased the target dose confidence, however the actual minimum CTV dose at 90% confidence typically exceeded the minimum PTV dose by 20% of prescription. Incorporation of smooth dose-effect relations within the optimization led to more concentrated dose distributions compared to the use of a PTV, with an improved balance between the probability of tumor cell kill and the risk of geometrical miss, and lower dose to surrounding tissues. Tumor control rate improvements in excess of 20% were found to be common for equal integral dose, while at the same time evading a nearby OAR. These results were robust against uncertainties in dose-effect relations and target heterogeneity, and did not depend on ‘shoulders’ or ‘horns’ in the dose distributions.

  18. Identification of the suitable leaf margin for liver stereotactic body radiotherapy with flattening filter-free beams. (United States)

    Ogata, Toshiyuki; Nishimura, Hideki; Mayahara, Hiroshi; Uehara, Kazuyuki; Okayama, Takanobu


    The purpose of this study is to identify the suitable leaf margin for liver stereotactic body radiotherapy (SBRT) with flattening filter-free (FFF) beams, as compared with that with flattening filter (FF) beams. SBRT treatment planning for 10 patients with liver cancer was performed using 10-MV FFF and FF beams obtained from a Varian TrueBeam (Varian Medical Systems, Palo Alto, CA) linear accelerator. Each plan was generated with the leaf margin to the planning target volume (PTV) ranging from -3 to 5 mm. The prescription dose at D95 (dose covering 95% of the volume) was 48 Gy in 4 fractions to the PTV. The following dosimetric parameters were evaluated quantitatively: homogeneity index (HI), conformity index (CI), gradient index (GI), the normal liver receiving a dose greater than or equal to 20 Gy (V20), and the mean normal liver dose. The HI for FFF and FF beams increased as the leaf margin decreased. The leaf margins that achieved the best CI and GI were 0.1 and -0.3 mm for FFF beams, and 0.1 and -0.9 mm for FF beams. The liver V20 and the mean liver dose reached their minimum values at leaf margins of -0.8 and 0.0 mm for FFF beams, and -0.8 and 0.0 mm for FF beams. The suitable leaf margin for SBRT planning did not differ significantly for FFF and FF beams. Our data showed that, for both FFF and FF beams, a leaf margin of 0 or -1 mm was optimal for liver SBRT planning in terms of both target coverage and normal tissue sparing. Copyright © 2017 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.

  19. Hybrid PIV-PTV technique for measuring blood flow in rat mesenteric vessels. (United States)

    Ha, Hojin; Nam, Kweon-Ho; Lee, Sang Joon


    The micro-particle tracking velocimetry (μ-PTV) technique is used to obtain the velocity fields of blood flow in the microvasculature under in vivo conditions because it can provide the blood velocity distribution in microvessels with high spatial resolution. The in vivo μ-PTV technique usually requires a few to tens of seconds to obtain a whole velocity profile across the vessel diameter because of the limited number density of tracer particles under in vivo conditions. Thus, the μ-PTV technique alone is limited in measuring unsteady blood flows that fluctuate irregularly due to the heart beating and muscle movement in surrounding tissues. In this study, a new hybrid PIV-PTV technique was established by combining PTV and particle image velocimetry (PIV) techniques to resolve the drawbacks of the μ-PTV method in measuring blood flow in microvessels under in vivo conditions. Images of red blood cells (RBCs) and fluorescent particles in rat mesenteric vessels were obtained simultaneously. Temporal variations of the centerline blood velocity were monitored using a fast Fourier transform-based cross-correlation PIV method. The fluorescence particle images were analyzed using the μ-PTV technique to extract the spatial distribution of the velocity vectors. Data from the μ-PTV and PIV methods were combined to obtain a better estimate of the velocity profile in actual blood flow. This technique will be useful in investigating hemodynamics in microcirculation by measuring unsteady irregular blood flows more accurately.


    Institute of Scientific and Technical Information of China (English)


    To measure the surface flow in a physical river model, an improved system of Large-Scale Particle Tracking Velocimetry (LSPTV) was proposed and the elements of the PTV system were described. Usually the tracer particles of a PTV system seeded on water surface tend to form conglomerates due to surface tension of water. In addition, they can not float on water surface when water flow is shallow. Ellipsoid particles were used to avoid the above problems. Another important issue is particle recognition. In order to eliminate the influence of noise, particles were recognized by the processing of multi-frame images. The kernel of the improved PTV system is the algorithm for particle tracking. A new 3-frame PTV algorithm was developed. The performance of this algorithm was compared with the conventional 4-frame PTV algorithm and 2-frame PTV algorithm by means of computer simulation using synthetically generated images. The results show that the new 3-frame PTV algorithm can recover more velocity vectors and have lower relative error. In addition, in order to attain the whole flow field from individual flow fields, the method of stitching individual flow fields by obvious marks was worked out. Then the improved PTV system was applied to the measurement of surface flow field in Model Yellow River and shows good performance.

  1. Volumetric microscale particle tracking velocimetry (PTV) in porous media (United States)

    Guo, Tianqi; Aramideh, Soroush; Ardekani, Arezoo M.; Vlachos, Pavlos P.


    The steady-state flow through refractive-index-matched glass bead microchannels is measured using microscopic particle tracking velocimetry (μPTV). A novel technique is developed to volumetrically reconstruct particles from oversampled two-dimensional microscopic images of fluorescent particles. Fast oversampling of the quasi-steady-state flow field in the lateral direction is realized by a nano-positioning piezo stage synchronized with a fast CMOS camera. Experiments at different Reynolds numbers are carried out for flows through a series of both monodispersed and bidispersed glass bead microchannels with various porosities. The obtained velocity fields at pore-scale (on the order of 10 μm) are compared with direct numerical simulations (DNS) conducted in the exact same geometries reconstructed from micro-CT scans of the glass bead microchannels. The developed experimental method would serve as a new approach for exploring the flow physics at pore-scale in porous media, and also provide benchmark measurements for validation of numerical simulations.

  2. SU-E-T-288: Dose Volume Population Histogram (DVPH): A New Method to Evaluate Intensity Modulated Proton Therapy Plans With Geometrical Uncertainties

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, T; Mai, N [University of Science, Ho Chi Minh City (Viet Nam); Nguyen, B [Prowess Inc, Concord, CA (United States)


    Purpose: In Proton therapy, especially intensity modulated proton therapy(IMPT), the dose distribution shape is very sensitive to errors due to sharp dose gradients at the Bragg peaks. The concept of the conventional margin is based on the assumption that dose distribution is shifted rather than deformed due to geometrical uncertainties. The goal of this study is to access the validity of the margin concept as well as propose a new approach using Dose Volume Population Histogram (DVPH) in evaluating IMPT plans. Methods: For a prostate case, an intensity modulated proton therapy is optimized based on the conventional PTV based objective function. The plan is evaluated based on the PTV DVH and CTV DVPH (dose volume population histogram) which explicitly taking into account geometric uncertainties. The DVPH is calculated based on 2197 dose distributions at different CTV possible positions for both random and systematic errors. The DVPH with a 90% confidence level is used for the comparison. Results: The minimum dose of the CTV DVPH with a 90% confidence level is only about 18% of the prescribed dose, while the minimum dose of the PTV is 95%. For bladder DVHs, the D50 and D35 is 26% and 30%, compared to 65% and 70% of the prescribed dose from the bladder DVPH with 90% confidence level. Conclusion: The results showed that the PTV concept for ensuring the prescribed dose actually delivered to the CTV is invalid in proton therapy. The good PTV DVH might Result in an underdose to the target and should not be used for IMPT optimization. For OARs, the conventional evaluation approach underestimates dose volume end points. The new concept DVPH has been proved to provide a more accurate DVH evaluation in proton therapy.

  3. SU-E-T-05: 4D Measurement-Guided Dose Reconstruction (4D-MGDR) in End-End Quality Assurance (E2E QA) for Assessing Safety Margin in Radiosurgery (SRS) From Clinical Perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Chan, M; Leung, R; Wong, M; Lee, V; Law, G; Lee, K; Tung, S [Tuen Mun Hospital, Hong Kong (China); Blanck, O [University Clinic Schleswig-Holstein, Kiel (Germany)


    Purpose: To assess the plan robustness and safety margin in SRS from 4DMGDR in E2E QA based on clinical objectives. Methods: OCTAVIUS SRS 1000 detector array and 4D phantom (PTW, Freiburg, Germany) were used to measure 5 coplanar SRS plans with 1 and 2 mm planning target volume (PTV). 3 targets were clinical, and 2 were virtual simulated to be 1mm from the brainstem (BS), and between chiasm (CS) and optic nerve (ON). Planning was done on Monaco v5.0 (Elekta, Maryland Heights, MO) to achieve 95–99% PTV and 100% gross tumor volume (GTV) prescription dose coverage. CBCT setup of the 4D phantom by 6D robotic couch was performed as for real patient. 4D-MGDR in patient CT and dosimetric analysis were performed in PTW Verisoft v6.1. The safety margin that achieved 100% GTV coverage was determined, and doses to 2% (D2%) of BS, ON and CS were assessed from E2E QA. Results: 100% GTV coverage was achieved with 1mm margin for 2 plans and 2mm margin for all plans. 98.3% and 99.4% GTV coverage were found in E2E QA for 1mm PTVs that either had sharp changing contour, or was nearby CS and ON or BS, and had either low planned minimum GTV dose (∼101% of the prescribed dose vs.∼106%) or compromised PTV coverage (95% vs. 99%). D2% to CS obtained with 4D-MGDR for one virtual target were 18.8Gy for 1mm PTV and 19.2Gy for 2mm PTV, exceeding the planned tolerance of 18Gy/3 fractions for prescription dose of 24Gy. Conclusion: 1mm margin is generally sufficient for dose planning and machine delivery errors. Irregular GTV with just enough dose coverage to spare critical organs may need 2mm margin at the costs of possible higher organ doses. 4D MGDR in an E2E QA approach can put the treatment plan evaluation in clinical perspectives.

  4. SU-E-P-40: Dosimetric Characteristics of Field Aperture Margin Design in Stereotactic Body Radiation Therapy (SBRT)

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, J


    Purpose: To characterize the dosimetric effects of field aperture margin design in Stereotactic Body Radiation Therapy (SBRT). Methods: Three artificial spherical PTVs, with diameter of 10mm, 20mm and 30mm, were created on CT images of a human body thoracic phantom. Seven non-coplanar isocentric fields were used for treatment planning. For each PTV, treatment plans with margins 0mm, 1mm, 2mm and 3mm were planned. Dosimetric comparison among plans was done considering the following parameters: prescribed isodose line for target coverage, maximum dose, mean dose as well as dose spillages of V80, V50, and V20. Results: Corresponding to aperture margins of 0mm, 1mm,2m and 3mm used in the treatment planning, the percentage of isodose line chosen for dose prescription increases from 65% to 93% for 10mm PTV, 70% to 92% for 20mm PTV, and 75% to 92% for 30mm PTV. The maximum dose decrease accordingly from 155.7% to 109.5% for 10mm PTV, 145% to 111.6% for 20mm PTV, 137% to 112.2% for 30mm PTV. The mean dose decrease from 138.% to 104.4% for 10mm PTV, 122.8% to 106.1% for 20mm PTV, 121.3% to 106% for 30mm PTV. Dose spillages (mm3) increase (V80−2.6 to 4.02, V50−4.55 to 9.3, V20–87.86 to 101.71) for 10 mm PTV, (V80−6.78 to 9.89, V50–13.46 to 20.4, V20-119.16 to 219.1) for 20 mm PTV, (V80–22.01 to 28.59, V50–41.56 to 52.66, V20-532.71 to 551.84) for 30 mm PTV. Conclusion: In SBRT treatment planning, tight field aperture margin requires prescribing dose to lower isodose line that leading to higher dose inhomogeneity and higher mean dose to PTV. Loose margin allows prescribing dose to higher isodose line, therefore improves the dose homogeneity. However, it increases dose spillages. Clinician could try different margins according to the PTV size and location of surrounding critical organs to optimize the dose delivered to the patient.

  5. Dune formation in dilute phase pneumatic transport system: PIV & PTV based analysis (United States)

    Jhalani, Sumit; Patankar, Atharva; Makawana, Ajay; Bose, Manaswita


    Flow of gas-solid mixture through horizontal conveying section show a large variety of phenomena and is broadly classified into dilute and dense unstable regimes. Different types of instabilities are observed in the dense phase flow and are widely studied in literature; however, clustering instabilities are observed in the very dilute regime of flow with volume fraction 0.001. A recent study has shown that regular, stable dune shaped clusters are formed in a small regime of the dilute phase of conveying. The dunes become unstable as the superficial gas velocity is decreased before it finally leads to the dense mode of conveying. The motivation of the current work is to investigate the velocity distribution on the surface of the stable and unstable dunes and thereby understand the cause behind the formation of the dunes in the conveying section. To that end, particle image and tracking velocimetry techniques are employed with the specific objective to determine the volume fraction and the velocity profile of the solid phase on the stable dune surface. A drastic change in the solid fraction within a few particle diameters from the dune surface suggests that PTV is more appropriate in the bulk whereas PIV is suitable for near surface investigation.

  6. Disease Control After Reduced Volume Conformal and Intensity Modulated Radiation Therapy for Childhood Craniopharyngioma

    Energy Technology Data Exchange (ETDEWEB)

    Merchant, Thomas E., E-mail: [St Jude Children' s Research Hospital, Radiological Sciences, Memphis, Tennessee (United States); Kun, Larry E.; Hua, Chia-Ho [St Jude Children' s Research Hospital, Radiological Sciences, Memphis, Tennessee (United States); Wu, Shengjie; Xiong, Xiaoping [St Jude Children' s Research Hospital, Biostatistics, Memphis, Tennessee (United States); Sanford, Robert A.; Boop, Frederick A. [Semmes Murphey Neurologic and Spine Institute, Neurosurgery, Memphis, Tennessee (United States)


    Purpose: To estimate the rate of disease control after conformal radiation therapy using reduced clinical target volume (CTV) margins and to determine factors that predict for tumor progression. Methods and Materials: Eighty-eight children (median age, 8.5 years; range, 3.2-17.6 years) received conformal or intensity modulated radiation therapy between 1998 and 2009. The study group included those prospectively treated from 1998 to 2003, using a 10-mm CTV, defined as the margin surrounding the solid and cystic tumor targeted to receive the prescription dose of 54 Gy. The CTV margin was subsequently reduced after 2003, yielding 2 groups of patients: those treated with a CTV margin greater than 5 mm (n=26) and those treated with a CTV margin less than or equal to 5 mm (n=62). Disease progression was estimated on the basis of additional variables including sex, race, extent of resection, tumor interventions, target volume margins, and frequency of weekly surveillance magnetic resonance (MR) imaging during radiation therapy. Median follow-up was 5 years. Results: There was no difference between progression-free survival rates based on CTV margins (>5 mm vs ≤5 mm) at 5 years (88.1% ± 6.3% vs 96.2% ± 4.4% [P=.6386]). There were no differences based on planning target volume (PTV) margins (or combined CTV plus PTV margins). The PTV was systematically reduced from 5 to 3 mm during the time period of the study. Factors predictive of superior progression-free survival included Caucasian race (P=.0175), no requirement for cerebrospinal fluid shunting (P=.0066), and number of surveillance imaging studies during treatment (P=.0216). Patients whose treatment protocol included a higher number of weekly surveillance MR imaging evaluations had a lower rate of tumor progression. Conclusions: These results suggest that targeted volume reductions for radiation therapy using smaller margins are feasible and safe but require careful monitoring. We are currently investigating

  7. Respiratory-gated (4D) contrast-enhanced FDG PET-CT for radiotherapy planning of lower oesophageal carcinoma: feasibility and impact on planning target volume. (United States)

    Scarsbrook, Andrew; Ward, Gillian; Murray, Patrick; Goody, Rebecca; Marshall, Karen; McDermott, Garry; Prestwich, Robin; Radhakrishna, Ganesh


    To assess the feasibility and potential impact on target delineation of respiratory-gated (4D) contrast-enhanced (18)Fluorine fluorodeoxyglucose (FDG) positron emission tomography - computed tomography (PET-CT), in the treatment planning position, for a prospective cohort of patients with lower third oesophageal cancer. Fifteen patients were recruited into the study. Imaging included 4D PET-CT, 3D PET-CT, endoscopic ultrasound and planning 4D CT. Target volume delineation was performed on 4D CT, 4D CT with co-registered 3D PET and 4D PET-CT. Planning target volumes (PTV) generated with 4D CT (PTV4DCT), 4D CT co-registered with 3D PET-CT (PTV3DPET4DCT) and 4D PET-CT (PTV4DPETCT) were compared with multiple positional metrics. Mean PTV4DCT, PTV3DPET4DCT and PTV4DPETCT were 582.4 ± 275.1 cm(3), 472.5 ± 193.1 cm(3) and 480.6 ± 236.9 cm(3) respectively (no significant difference). Median DICE similarity coefficients comparing PTV4DCT with PTV3DPET4DCT, PTV4DCT with PTV4DPETCT and PTV3DPET4DCT with PTV4DPETCT were 0.85 (range 0.65-0.9), 0.85 (range 0.69-0.9) and 0.88 (range 0.79-0.9) respectively. The median sensitivity index for overlap comparing PTV4DCT with PTV3DPET4DCT, PTV4DCT with PTV4DPETCT and PTV3DPET4DCT with PTV4DPETCT were 0.78 (range 0.65-0.9), 0.79 (range 0.65-0.9) and 0.89 (range 0.68-0.94) respectively. Planning 4D PET-CT is feasible with careful patient selection. PTV generated using 4D CT, 3D PET-CT and 4D PET-CT were of similar volume, however, overlap analysis demonstrated that approximately 20% of PTV3DPETCT and PTV4DPETCT are not included in PTV4DCT, leading to under-coverage of target volume and a potential geometric miss. Additionally, differences between PTV3DPET4DCT and PTV4DPETCT suggest a potential benefit for 4D PET-CT. Identifier - NCT02285660 (Registered 21/10/2014).

  8. Simultaneous measurements of jellyfish bell kinematics and flow fields using PTV and PIV (United States)

    Xu, Nicole; Dabiri, John


    A better understanding of jellyfish swimming can potentially improve the energy efficiency of aquatic vehicles or create biomimetic robots for ocean monitoring. Aurelia aurita is a simple oblate invertebrate composed of a flexible bell and coronal muscle, which contracts to eject water from the subumbrellar volume. Jellyfish locomotion can be studied by obtaining body kinematics or by examining the resulting fluid velocity fields using particle image velocimetry (PIV). Typically, swim kinematics are obtained by semi-manually tracking points of interest (POI) along the bell in video post-processing; simultaneous measurements of kinematics and flows involve using this semi-manual tracking method on PIV videos. However, we show that both the kinematics and flow fields can be directly visualized in 3D space by embedding phosphorescent particles in animals free-swimming in seeded environments. Particle tracking velocimetry (PTV) can then be used to calculate bell kinematics, such as pulse frequency, bell deformation, swim trajectories, and propulsive efficiency. By simultaneously tracking POI within the bell and collecting PIV data, we can further study the jellyfish's natural locomotive control mechanisms in conjunction with flow measurements. NSF GRFP.

  9. Loss of local control due to tumor displacement as a function of margin size, dose-response slope, and number of fractions. (United States)

    Selvaraj, Jothybasu; Uzan, Julien; Baker, Colin; Nahum, Alan


    Geometric uncertainties are inevitable in radiotherapy. To account for these uncertainties, a margin is added to the clinical target volume (CTV) to create the planning target volume (PTV), and its size is critical for obtaining an optimal treatment plan. Dose-based (i.e., physical) margin recipes have been published and widely used, but it is important to consider fractionation and the radiobiological characteristics of the tumor when deriving margins. Hence a tumor control probability (TCP)-based margin is arguably more appropriate. Margins required for ≤ 1% loss in mean population TCP (relative to a static tumor) for varying numbers of fractions, varying slope of the dose-response curve (γ50) and varying degrees of dose distribution conformity are investigated for spherical and four-field (4F)-brick dose distributions. To simulate geometric uncertainties, systematic (Σ) and random (σ) tumor displacements were sampled from Gaussian distributions and applied to each fraction for a spherical CTV. Interfraction tumor motion was simulated and the dose accumulated from fraction to fraction on a voxel-by-voxel basis to calculate TCP. PTV margins derived from this work for various fraction numbers and dose-response slopes (γ50) for different degrees of geometric uncertainties are compared with margins calculated using published physical-dose- and TCP-based recipes. Larger margins are required for a decrease in the number of fractions and for an increase in γ50 for both spherical and 4F-brick dose distributions. However, the margins can be close to zero for the 4F-brick distribution for small geometric uncertainties (Σ = 1, σ = 1 mm) irrespective of the number of fractions and the magnitude of γ50 due to the higher "incidental" dose outside the tumor. For Σ = 1 mm and σ = 3 mm, physical-dose-based recipes underestimate the margin only for the combination of hypofractionated treatments and tumors with a high γ50. For all other situations TCP-based margins are

  10. Outcomes and Patterns of Failure for Grade 2 Meningioma Treated With Reduced-Margin Intensity Modulated Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Press, Robert H. [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Prabhu, Roshan S., E-mail: [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Appin, Christina L.; Brat, Daniel J. [Department of Pathology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Shu, Hui-Kuo G. [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Hadjipanayis, Constantinos; Olson, Jeffrey J.; Oyesiku, Nelson M. [Department of Neurosurgery, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Curran, Walter J.; Crocker, Ian [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States)


    Purpose: The purpose of this study was to evaluate intracranial control and patterns of local recurrence (LR) for grade 2 meningiomas treated with intensity modulated radiation therapy (IMRT) with limited total margin expansions of ≤1 cm. Methods and Materials: We reviewed records of patients with a neuropathological diagnosis of grade 2 meningioma who underwent IMRT at our institution between 2002 and 2012. Actuarial rates were determined by the Kaplan-Meier method from the end of RT. LR was defined as in-field if ≥90% of the recurrence was within the prescription isodose, out-of-field (marginal) if ≥90% was outside of the prescription isodose, and both if neither criterion was met. Results: Between 2002 and 2012, a total of 54 consecutive patients underwent IMRT for grade 2 meningioma. Eight of these patients had total initial margins >1 cm and were excluded, leaving 46 patients for analysis. The median imaging follow-up period was 26.2 months (range, 7-107 months). The median dose for fractionated IMRT was 59.4 Gy (range, 49.2-61.2 Gy). Median clinical target volume (CTV), planning target volume (PTV), and total margin expansion were 0.5 cm, 0.3 cm, and 0.8 cm, respectively. LR occurred in 8 patients (17%), with 2-year and 3-year actuarial local control (LC) of 92% and 74%, respectively. Six of 8 patients (85%) had a known pattern of failure. Five patients (83%) had in-field LR; no patients had marginal LR; and 1 patient (17%) had both. Conclusions: The use of IMRT to treat grade 2 meningiomas with total initial margins (CTV + PTV) ≤1 cm did not appear to compromise outcomes or increase marginal failures compared with other modern retrospective series. Of the 46 patients who had margins ≤1 cm, none experienced marginal failure only. These results demonstrate efficacy and low risk of marginal failure after IMRT treatment of grade 2 meningiomas with reduced margins, warranting study within a prospective clinical trial.

  11. SU-F-R-47: Quantitative Shape Relationship Analysis of PTV Modification for Critical Anatomy Sparing and Its Impact On Pathologic Response for Neoadjuvant Stereotactic Radiotherapy for Pancreatic Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Z; Rosati, L; Chen, L; Robertson, S; Moore, J; Peng, L; Mian, O; Narang, A; Hacker-Prietz, A; Herman, J; McNutt, T [Johns Hopkins University, Baltimore, MD (United States)


    Purpose: Stereotactic body radiation therapy (SBRT) may be used to increase surgery candidacy in borderline resectable (BRPC) and locally advanced (LAPC) pancreatic cancer. However, the planning target volume (PTV) may need to be limited to avoid toxicity when the gross tumor volume (GTV) is anatomically involved with surrounding critical structures. Our study aims to characterize the coverage of GTV and investigate the association between modified PTV and pathologic (pCR) or near pathologic (npCR) complete response rates determined from the surgical specimen. Methods: Patients treated with neoadjuvant pancreas SBRT followed by surgery from 2010–2015 were selected from Oncospace. Overlap volume histogram (OVH) analysis was performed to determine the extent of compromise of the PTV from both the GTV and a standard target (GTV+3mm). Subsequently, normalized overlap volume (%) was calculated for: (1) GTV-PTV, and (2) GTV+3mm expansion-PTV. A logistic regression model was used to identify the association between the overlap ratios and ≥ npCR(pCR/npCR) stratified by active breathing control (ABC) versus free-breathing status. Results: Eighty-one (BRPC: n=42, LAPC: n=39) patients were available for analysis. Nearly 40% (31/81) had ≥npCR and 75% (61/81) were able to complete ABC. Mean coverage of the GTV-PTV was 92.6% (range, 59.9%–100%, SD = 8.68) and coverage of the GTV+3mm expansion-PTV was 85. 2% (range, 59.9% −100.0%, SD= 8.67). Among the patients with ABC, every 10% increase in GTV coverage doubled the odds to have ≥npCR (OR = 1.82, p=0.06). Coverage of GTV+3mm expansion was not associated with ≥npCR regardless of ABC status. Conclusion: Preferential sparing of critical anatomy over GTV-PTV coverage with ABC management suggests worse ≥npCR rates for neoadjuvant SBRT in BRPC and LAPC. Limiting the GTV and GTV+3mm expansion in free-breathing patients was not associated with pathologic response perhaps due to larger GTV definitions as a result of motion

  12. Study of the seroma volume changes in the patients who underwent Accelerated Partial Breast Irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dae Ho; Son, Sang Jun; Mun, Jun Ki; Seo, Seok Jin; Lee, Je Hee [Dept. of Radiation Oncology, Seoul National University Hospital, Seoul (Korea, Republic of)


    By analyzing seroma volume changes in the patients who underwent Partial breast radiation therapy after breast conserving surgery, we try to contribute to the improvement of radiotherapy effect. Enrolled 20 patients who underwent partial breast radiation therapy by ViewRay MRIdian System were subject. After seeking for the size of the removed sample in the patients during surgery and obtained seroma volume changes on a weekly basis. On the Basis of acquired volume, it was compared with age, term from start of the first treatment after surgery, BMI (body mass index) and the extracted sample size during surgery. And using the ViewRay MRIdian RTP System, the figure was analyzed by PTV(=seroma volume + margin) to obtain a specific volume of the Partial breast radiation therapy. The changes of seroma volume from MR simulation to the first treatment (a week) is 0~5% in 8, 5~10% in 3, 10 to 15% in 2, and 20% or more in 5 people. Two patients(A, B patient) among subjects showed the biggest change. The A patient's 100% of the prescribed dose volume is 213.08 cc, PTV is 181.93 cc, seroma volume is 15.3 cc in initial plan. However, while seroma volume decreased 65.36% to 5.3 cc, 100% of the prescribed dose volume was reduced to 3.4% to 102.43 cc and PTV also did 43.6% to 102.54 cc. In the case of the B patient, seroma volume decreased 42.57% from 20.2 cc to 11.6 cc. Because of that, 100% of the prescribed dose volume decreased 8.1% and PTV also did to 40%. As the period between the first therapy and surgery is shorter, the patient is elder and the size of sample is smaller than 100 cc, the change grow bigger. It is desirable to establish an adaptive plan according to each patient's changes of seroma volume through continuous observation. Because partial breast patients is more sensitive than WBRT patients about dose conformity in accordance with the volume change.

  13. A predictive model to guide management of the overlap region between target volume and organs at risk in prostate cancer volumetric modulated arc therapy

    Energy Technology Data Exchange (ETDEWEB)

    Mattes, Malcolm D.; Lee, Jennifer C.; Einaiem, Sara; Guirguis, Adel; Ikoro, N. C.; Ashamalla Hani [Dept. of Radiation Oncology, New York Methodist Hospital, Brooklyn (United States)


    The goal of this study is to determine whether the magnitude of overlap between planning target volume (PTV) and rectum (Rectum{sub overlap}) or PTV and bladder (Bladder{sub overlap}) in prostate cancer volumetric-modulated arc therapy (VMAT) is predictive of the dose-volume relationships achieved after optimization, and to identify predictive equations and cutoff values using these overlap volumes beyond which the Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC) dose-volume constraints are unlikely to be met. Fifty-seven patients with prostate cancer underwent VMAT planning using identical optimization conditions and normalization. The PTV (for the 50.4 Gy primary plan and 30.6 Gy boost plan) included 5 to 10 mm margins around the prostate and seminal vesicles. Pearson correlations, linear regression analyses, and receiver operating characteristic (ROC) curves were used to correlate the percentage overlap with dose-volume parameters. The percentage Rectum{sub overlap} and Bladder{sub overlap} correlated with sparing of that organ but minimally impacted other dose-volume parameters, predicted the primary plan rectum V{sub 45} and bladder V{sub 50} with R{sup 2} = 0.78 and R{sup 2} = 0.83, respectively, and predicted the boost plan rectum V{sub 30} and bladder V{sub 30} with R{sup 2} = 0.53 and R{sup 2} = 0.81, respectively. The optimal cutoff value of boost Rectumoverlap to predict rectum V75 >15% was 3.5% (sensitivity 100%, specificity 94%, p < 0.01), and the optimal cutoff value of boost Bladder{sub overlap} to predict bladder V{sub 80} >10% was 5.0% (sensitivity 83%, specificity 100%, p < 0.01). The degree of overlap between PTV and bladder or rectum can be used to accurately guide physicians on the use of interventions to limit the extent of the overlap region prior to optimization.

  14. Characterization of PTV-12, a newly described porcine teschovirus serotype: in vivo infection and cross-protection studies. (United States)

    Cano-Gómez, Cristina; Fernández-Pinero, Jovita; García-Casado, María Ana; Zell, Roland; Jiménez-Clavero, Miguel Angel


    Porcine teschoviruses (PTVs) constitute 1 of the 31 genera within the Picornaviridae family, comprising at least 13 genetic types (PTV-1 to PTV-13), of which only 11 (PTV-1 to PTV-11) have been recognized as serotypes to date. Specific for swine and wild boars, most PTVs are usually non-pathogenic, but some viral variants cause severe disorders in the central nervous system (Teschen disease) or milder signs (Talfan disease), as well as reproductive, digestive and respiratory disorders and skin lesions. Previous studies revealed a high diversity of teschoviruses circulating in Spanish pig populations. Phylogenetic analysis performed with these sequences and others available in GenBank disclosed 13 clusters, 11 of which corresponded to the known PTV serotypes, and 1 of 2 additional groups is represented by isolate CC25, whose full-length genomic sequence has been obtained. This group is new to science, and was putatively named PTV-12. Here, a complete characterization of this isolate is presented, including the experimental infection of minipigs to assess tissue tropism and possible pathogenicity in vivo in the host species. In addition, using this experimental animal model, we investigated whether a pre-existing infection with this PTV-12 isolate could confer cross-protection against infection with a heterotypic PTV-1 virulent strain. Based on phylogenetic analysis and serological data, we propose CC25 as the prototype strain of a new teschovirus serotype, PTV-12.

  15. Analysis of the Setup Uncertainty and Margin of the Daily ExacTrac 6D Image Guide System for Patients with Brain Tumors.

    Directory of Open Access Journals (Sweden)

    Se An Oh

    Full Text Available This study evaluated the setup uncertainties for brain sites when using BrainLAB's ExacTrac X-ray 6D system for daily pretreatment to determine the optimal planning target volume (PTV margin. Between August 2012 and April 2015, 28 patients with brain tumors were treated by daily image-guided radiotherapy using the BrainLAB ExacTrac 6D image guidance system of the Novalis-Tx linear accelerator. DUONTM (Orfit Industries, Wijnegem, Belgium masks were used to fix the head. The radiotherapy was fractionated into 27-33 treatments. In total, 844 image verifications were performed for 28 patients and used for the analysis. The setup corrections along with the systematic and random errors were analyzed for six degrees of freedom in the translational (lateral, longitudinal, and vertical and rotational (pitch, roll, and yaw dimensions. Optimal PTV margins were calculated based on van Herk et al.'s [margin recipe = 2.5∑ + 0.7σ - 3 mm] and Stroom et al.'s [margin recipe = 2∑ + 0.7σ] formulas. The systematic errors (∑ were 0.72, 1.57, and 0.97 mm in the lateral, longitudinal, and vertical translational dimensions, respectively, and 0.72°, 0.87°, and 0.83° in the pitch, roll, and yaw rotational dimensions, respectively. The random errors (σ were 0.31, 0.46, and 0.54 mm in the lateral, longitudinal, and vertical rotational dimensions, respectively, and 0.28°, 0.24°, and 0.31° in the pitch, roll, and yaw rotational dimensions, respectively. According to van Herk et al.'s and Stroom et al.'s recipes, the recommended lateral PTV margins were 0.97 and 1.66 mm, respectively; the longitudinal margins were 1.26 and 3.47 mm, respectively; and the vertical margins were 0.21 and 2.31 mm, respectively. Therefore, daily setup verifications using the BrainLAB ExacTrac 6D image guide system are very useful for evaluating the setup uncertainties and determining the setup margin.

  16. Analysis of the Setup Uncertainty and Margin of the Daily ExacTrac 6D Image Guide System for Patients with Brain Tumors. (United States)

    Oh, Se An; Yea, Ji Woon; Kang, Min Kyu; Park, Jae Won; Kim, Sung Kyu


    This study evaluated the setup uncertainties for brain sites when using BrainLAB's ExacTrac X-ray 6D system for daily pretreatment to determine the optimal planning target volume (PTV) margin. Between August 2012 and April 2015, 28 patients with brain tumors were treated by daily image-guided radiotherapy using the BrainLAB ExacTrac 6D image guidance system of the Novalis-Tx linear accelerator. DUONTM (Orfit Industries, Wijnegem, Belgium) masks were used to fix the head. The radiotherapy was fractionated into 27-33 treatments. In total, 844 image verifications were performed for 28 patients and used for the analysis. The setup corrections along with the systematic and random errors were analyzed for six degrees of freedom in the translational (lateral, longitudinal, and vertical) and rotational (pitch, roll, and yaw) dimensions. Optimal PTV margins were calculated based on van Herk et al.'s [margin recipe = 2.5∑ + 0.7σ - 3 mm] and Stroom et al.'s [margin recipe = 2∑ + 0.7σ] formulas. The systematic errors (∑) were 0.72, 1.57, and 0.97 mm in the lateral, longitudinal, and vertical translational dimensions, respectively, and 0.72°, 0.87°, and 0.83° in the pitch, roll, and yaw rotational dimensions, respectively. The random errors (σ) were 0.31, 0.46, and 0.54 mm in the lateral, longitudinal, and vertical rotational dimensions, respectively, and 0.28°, 0.24°, and 0.31° in the pitch, roll, and yaw rotational dimensions, respectively. According to van Herk et al.'s and Stroom et al.'s recipes, the recommended lateral PTV margins were 0.97 and 1.66 mm, respectively; the longitudinal margins were 1.26 and 3.47 mm, respectively; and the vertical margins were 0.21 and 2.31 mm, respectively. Therefore, daily setup verifications using the BrainLAB ExacTrac 6D image guide system are very useful for evaluating the setup uncertainties and determining the setup margin.

  17. 3D-PTV around Operational Wind Turbines (United States)

    Brownstein, Ian; Dabiri, John


    Laboratory studies and numerical simulations of wind turbines are typically constrained in how they can inform operational turbine behavior. Laboratory experiments are usually unable to match both pertinent parameters of full-scale wind turbines, the Reynolds number (Re) and tip speed ratio, using scaled-down models. Additionally, numerical simulations of the flow around wind turbines are constrained by the large domain size and high Re that need to be simulated. When these simulations are preformed, turbine geometry is typically simplified resulting in flow structures near the rotor not being well resolved. In order to bypass these limitations, a quantitative flow visualization method was developed to take in situ measurements of the flow around wind turbines at the Field Laboratory for Optimized Wind Energy (FLOWE) in Lancaster, CA. The apparatus constructed was able to seed an approximately 9m x 9m x 5m volume in the wake of the turbine using artificial snow. Quantitative measurements were obtained by tracking the evolution of the artificial snow using a four camera setup. The methodology for calibrating and collecting data, as well as preliminary results detailing the flow around a 2kW vertical-axis wind turbine (VAWT), will be presented.

  18. Volumetric-modulated arc therapy for the treatment of a large planning target volume in thoracic esophageal cancer. (United States)

    Abbas, Ahmar S; Moseley, Douglas; Kassam, Zahra; Kim, Sun Mo; Cho, Charles


    Recently, volumetric-modulated arc therapy (VMAT) has demonstrated the ability to deliver radiation dose precisely and accurately with a shorter delivery time compared to conventional intensity-modulated fixed-field treatment (IMRT). We applied the hypothesis of VMAT technique for the treatment of thoracic esophageal carcinoma to determine superior or equivalent conformal dose coverage for a large thoracic esophageal planning target volume (PTV) with superior or equivalent sparing of organs-at-risk (OARs) doses, and reduce delivery time and monitor units (MUs), in comparison with conventional fixed-field IMRT plans. We also analyzed and compared some other important metrics of treatment planning and treatment delivery for both IMRT and VMAT techniques. These metrics include: 1) the integral dose and the volume receiving intermediate dose levels between IMRT and VMATI plans; 2) the use of 4D CT to determine the internal motion margin; and 3) evaluating the dosimetry of every plan through patient-specific QA. These factors may impact the overall treatment plan quality and outcomes from the individual planning technique used. In this study, we also examined the significance of using two arcs vs. a single-arc VMAT technique for PTV coverage, OARs doses, monitor units and delivery time. Thirteen patients, stage T2-T3 N0-N1 (TNM AJCC 7th edn.), PTV volume median 395 cc (range 281-601 cc), median age 69 years (range 53 to 85), were treated from July 2010 to June 2011 with a four-field (n = 4) or five-field (n = 9) step-and-shoot IMRT technique using a 6 MV beam to a prescribed dose of 50 Gy in 20 to 25 F. These patients were retrospectively replanned using single arc (VMATI, 91 control points) and two arcs (VMATII, 182 control points). All treatment plans of the 13 study cases were evaluated using various dose-volume metrics. These included PTV D99, PTV D95, PTV V9547.5Gy(95%), PTV mean dose, Dmax, PTV dose conformity (Van't Riet conformation number (CN)), mean lung dose

  19. Defining the Optimal Planning Target Volume in Image-Guided Stereotactic Radiosurgery of Brain Metastases: Results of a Randomized Trial

    Energy Technology Data Exchange (ETDEWEB)

    Kirkpatrick, John P., E-mail: [Department of Radiation Oncology, Duke University, Durham, North Carolina (United States); Department of Surgery, Duke University, Durham, North Carolina (United States); Wang, Zhiheng [Department of Radiation Oncology, Duke University, Durham, North Carolina (United States); Sampson, John H. [Department of Radiation Oncology, Duke University, Durham, North Carolina (United States); Department of Surgery, Duke University, Durham, North Carolina (United States); McSherry, Frances; Herndon, James E. [Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina (United States); Allen, Karen J.; Duffy, Eileen [Department of Radiation Oncology, Duke University, Durham, North Carolina (United States); Hoang, Jenny K. [Department of Radiology, Duke University, Durham, North Carolina (United States); Chang, Zheng; Yoo, David S.; Kelsey, Chris R.; Yin, Fang-Fang [Department of Radiation Oncology, Duke University, Durham, North Carolina (United States)


    Purpose: To identify an optimal margin about the gross target volume (GTV) for stereotactic radiosurgery (SRS) of brain metastases, minimizing toxicity and local recurrence. Methods and Materials: Adult patients with 1 to 3 brain metastases less than 4 cm in greatest dimension, no previous brain radiation therapy, and Karnofsky performance status (KPS) above 70 were eligible for this institutional review board–approved trial. Individual lesions were randomized to 1- or 3- mm uniform expansion of the GTV defined on contrast-enhanced magnetic resonance imaging (MRI). The resulting planning target volume (PTV) was treated to 24, 18, or 15 Gy marginal dose for maximum PTV diameters less than 2, 2 to 2.9, and 3 to 3.9 cm, respectively, using a linear accelerator–based image-guided system. The primary endpoint was local recurrence (LR). Secondary endpoints included neurocognition Mini-Mental State Examination, Trail Making Test Parts A and B, quality of life (Functional Assessment of Cancer Therapy-Brain), radionecrosis (RN), need for salvage radiation therapy, distant failure (DF) in the brain, and overall survival (OS). Results: Between February 2010 and November 2012, 49 patients with 80 brain metastases were treated. The median age was 61 years, the median KPS was 90, and the predominant histologies were non–small cell lung cancer (25 patients) and melanoma (8). Fifty-five, 19, and 6 lesions were treated to 24, 18, and 15 Gy, respectively. The PTV/GTV ratio, volume receiving 12 Gy or more, and minimum dose to PTV were significantly higher in the 3-mm group (all P<.01), and GTV was similar (P=.76). At a median follow-up time of 32.2 months, 11 patients were alive, with median OS 10.6 months. LR was observed in only 3 lesions (2 in the 1 mm group, P=.51), with 6.7% LR 12 months after SRS. Biopsy-proven RN alone was observed in 6 lesions (5 in the 3-mm group, P=.10). The 12-month DF rate was 45.7%. Three months after SRS, no significant change in

  20. Differences in absorbed doses at risk organs and target tumoral of planning(PTV) in lung treatments using two algorithms of different calculations; Diferencias en las dosis absorbidas en organos de riesgo y volumen tumoral de planificacion (PTV) en tratamientos de pulmon usando dos algoritmos de calculo diferentes: pencil beam y collpased cone

    Energy Technology Data Exchange (ETDEWEB)

    Uruena Llinares, A.; Santos Rubio, A.; Luis Simon, F. J.; Sanchez Carmona, G.; Herrador Cordoba, M.


    The objective of this paper is to compare, in thirty treatments for lung cancer,the absorbed doses at risk organs and target volumes obtained between the two used algorithms of calculation of our treatment planning system Oncentra Masterplan, that is, Pencil Beams vs Collapsed Cone. For it we use a set of measured indicators (D1 and D99 of tumor volume, V20 of lung, homogeneity index defined as (D5-D95)/D prescribed, and others). Analysing the dta, making a descriptor analysis of the results, and applying the non parametric test of the ranks with sign of Wilcoxon we find that the use of Pencil Beam algorithm underestimates the dose in the zone of the PTV including regions of low density as well as the values of maximum dose in spine cord. So, we conclude that in those treatments in which the spine dose is near the maximum permissible limit or those in which the PTV it includes a zone with pulmonary tissue must be used the Collapse Cone algorithm systematically and in any case an analysis must become to choose between time and precision in the calculation for both algorithms. (Authors)

  1. Difference in the Set-up Margin between 2D Conventional and 3D CT Based Planning in Patients with Early Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Jo, Sun Mi; Chun, Mi Sun; Kim, Mi Hwa; Oh, Young Taek; Noh, O Kyu [Ajou University School of Medicine, Seoul (Korea, Republic of); Kang, Seung Hee [Inje University, Ilsan Paik Hospital, Ilsan (Korea, Republic of)


    Simulation using computed tomography (CT) is now widely available for radiation treatment planning for breast cancer. It is an important tool to help define the tumor target and normal tissue based on anatomical features of an individual patient. In Korea, most patients have small sized breasts and the purpose of this study was to review the margin of treatment field between conventional two-dimensional (2D) planning and CT based three-dimensional (3D) planning in patients with small breasts. Twenty-five consecutive patients with early breast cancer undergoing breast conservation therapy were selected. All patients underwent 3D CT based planning with a conventional breast tangential field design. In 2D planning, the treatment field margins were determined by palpation of the breast parenchyma (In general, the superior: base of the clavicle, medial: midline, lateral: mid - axillary line, and inferior margin: 2 m below the inflamammary fold). In 3D planning, the clinical target volume (CTV) ought to comprise all glandular breast tissue, and the PTV was obtained by adding a 3D margin of 1 cm around the CTV except in the skin direction. The difference in the treatment field margin and equivalent field size between 2D and 3D planning were evaluated. The association between radiation field margins and factors such as body mass index, menopause status, and bra size was determined. Lung volume and heart volume were examined on the basis of the prescribed breast radiation dose and 3D dose distribution. The margins of the treatment field were smaller in the 3D planning except for two patients. The superior margin was especially variable (average, 2.5 cm; range, -2.5 to 4.5 cm; SD, 1.85). The margin of these targets did not vary equally across BMI class, menopause status, or bra size. The average irradiated lung volume was significantly lower for 3D planning. The average irradiated heart volume did not decrease significantly. The use of 3D CT based planning reduced the

  2. A Round-based Pricing Scheme for Maximizing Service Provider's Revenue in P2PTV Networks

    CERN Document Server

    Bhutani, Gitanjali


    In this paper, we analyze a round-based pricing scheme that encourages favorable behavior from users of real-time P2P applications like P2PTV. In the design of pricing schemes, we consider price to be a function of usage and capacity of download/upload streams, and quality of content served. Users are consumers and servers at the same time in such networks, and often exhibit behavior that is unfavorable towards maximization of social benefits. Traditionally, network designers have overcome this difficulty by building-in traffic latencies. However, using simulations, we show that appropriate pricing schemes and usage terms can enable designers to limit required traffic latencies, and be able to earn nearly 30% extra revenue from providing P2PTV services. The service provider adjusts the prices of individual programs incrementally within rounds, while making relatively large-scale adjustments at the end of each round. Through simulations, we show that it is most beneficial for the service provider to carry out ...

  3. Pressure-field extraction from Lagrangian flow measurements: first experiences with 4D-PTV data (United States)

    Neeteson, N. J.; Bhattacharya, S.; Rival, D. E.; Michaelis, D.; Schanz, D.; Schröder, A.


    As a follow-up to a previous proof-of-principle study, a novel Lagrangian pressure-extraction technique is analytically evaluated, and experimentally validated using dense 4D-PTV data. The technique is analytically evaluated using the semi-three-dimensional Taylor-Green vortex, and it is found that the Lagrangian technique out-performs the standard Eulerian technique when Dirichlet boundary conditions are enforced. However, the Lagrangian technique produces worse estimates of the pressure field when Neumann boundary conditions are enforced on boundaries with strong pressure gradients. The technique is experimentally validated using flow data obtained for the case of a free-falling, index-matched sphere at Re=2100. The experimental data were collected using a four-camera particle tracking velocimetry measurement system, and processed using 4D-PTV. The pressure field is then extracted using both the Eulerian and Lagrangian techniques, and the resulting pressure fields are compared. Qualitatively, the pressure fields agree; however, quantitative differences are found with respect to the magnitude of the pressure minima on the side of the sphere. Finally, the pressure-drag coefficient is estimated using each technique, and the two techniques are found to be in very close agreement. A comparison to a reference value from literature confirms that the drag coefficient estimates are reasonable, demonstrating the validity of the technique.

  4. Resuspension of particles in an oscillating grid turbulent flow using PIV and 3D-PTV

    Energy Technology Data Exchange (ETDEWEB)

    Traugott, H; Liberzon, A [Turbulence Structure Laboratory, School of Mechanical Engineering, Tel Aviv University, Tel Aviv 69978 (Israel); Hayse, T, E-mail: [Department of Civil Engineering, Massachusetts Institute of Technology, MA (United States)


    Description of the mechanisms responsible for the initiation of particle motion from a surface and re-entrainment of particles into suspension remains a challenge, partially due to the technical difficulties to quantify the forces applied on the particles and the collection of high resolution data of particle displacements simultaneously. In this study we explore the process of initial entrainment of spherical particles from smooth beds into zero-mean-shear turbulent flow in an oscillating grid chamber. Particle image velocimetry (PIV) and three-dimensional particle tracking velocimetry (3D-PTV) are used to correlate in a quantitative manner the turbulent flow properties responsible for pick-up, detachment and re-entrainment of particles. The results are compared to the existing models of critical shear velocity and provide further insight into the resuspension process of spherical particles in the transitional range of particle size Reynolds numbers 2 {<=} Re{sub p} {<=} 500.

  5. Digital holographic PTV analysis of the motile performance of the red-tides alga ``Cochlodinium polykrikoides'' (United States)

    Sohn, M.; Lee, S.; Choi, Y.; Seo, G.; Kang, Y.; Kang, Y.


    The outbreaks of Cochlodinium polykrikoides causes severe damages to fisheries in Korea and Japan. C. polykrikoides actively makes chains in its exponential and stationary growth phase. The role of the chain formation has not been clearly known yet. In the present study, the motility characteristics of C. polykrikoides was investigated using 3D digital holographic PTV technique. The moving trajectories and average velocities of the single and multi-chained C. polykrikoides were compared to investigate the effect of the chain formation on the motile performance. Most of the multi-chained C. polykrikoides exhibited zigzag or helical trajectory and the translational velocity of the 4-chained C. polykrikoides was at least two-times larger than the single one.

  6. Resolving vorticity and dissipation in a turbulent boundary layer by tomographic PTV and VIC+ (United States)

    Schneiders, Jan F. G.; Scarano, Fulvio; Elsinga, Gerrit E.


    The existing time-resolved tomographic particle image velocimetry (PIV) measurements by Jodai and Elsinga (J Fluid Mech 795:611-633; Jodai, Elsinga, J Fluid Mech 795:611-633, 2016) in a turbulent boundary layer ( Re θ = 2038) are reprocessed using tomographic particle tracking velocimetry (PTV) and vortex-in-cell-plus (VIC+). The resulting small-scale flow properties, i.e. vorticity and turbulence dissipation, are compared. The VIC+ technique was recently proposed and uses the concept of pouring time into space to increase reconstruction quality of instantaneous velocity. The tomographic PTV particle track measurements are interpolated using VIC+ to a dense grid, making use of both particle velocity and Lagrangian acceleration. Comparison of the vortical structures by visualization of isosurfaces of vorticity magnitude shows that the two methods return similar coherent vortical structures, but their strength in terms of vorticity magnitude is increased when using VIC+, which suggests an improvement in spatial resolution. Further statistical evaluation shows that the root mean square (rms) of vorticity fluctuations from tomographic PIV is approximately 40% lower in comparison to a reference profile available from a DNS simulation, while the VIC+ technique returns rms vorticity fluctuations to within 10% of the reference. The dissipation rate is heavily underestimated by tomographic PIV with approximately 50% damping, whereas the VIC+ analysis yields a dissipation rate to within approximately 5% for y + > 25. The fact that dissipation can be directly measured by a volumetric experiment is novel. It differs from existing approaches that involve 2d measurements combined with isotropic turbulence assumptions or apply corrections based on sub-grid scale turbulence modelling. Finally, the study quantifies the spatial response of VIC+ with a sine-wave lattice analysis. The results indicate a twofold increase of spatial resolution with respect to cross

  7. Lagrangian and Eulerian statistics of pipe flows measured with 3D-PTV at moderate and high Reynolds numbers

    NARCIS (Netherlands)

    Oliveira, J.L.G.; Geld, van der C.W.M.; Kuerten, J.G.M.


    Three-dimensional particle tracking velocimetry (3D-PTV) measurements have provided accurate Eulerian and Lagrangian high-order statistics of velocity and acceleration fluctuations and correlations at Reynolds number 10,300, based on the bulk velocity and the pipe diameter. Spatial resolution requir

  8. Simultaneous PIV and PTV measurements of wind and sand particle velocities (United States)

    Zhang, Wei; Wang, Yuan; Lee, Sang Joon


    Wind-blown sand is a typical example of two-phase particle-laden flows. Owing to lack of simultaneous measured data of the wind and wind-blown sand, interactions between them have not yet been fully understood. In this study, natural sand of 100-125 μm taken from Taklimakan Desert was tested at the freestream wind speed of 8.3 m/s in an atmospheric boundary layer wind tunnel. The captured flow images containing both saltating sand and small wind tracer particles, were separated by using a digital phase mask technique. The 2-D PIV (particle imaging velocimetry) and PTV (particle tracking velocimetry) techniques were employed to extract simultaneously the wind velocity field and the velocity field of dispersed sand particles, respectively. Comparison of the mean streamwise wind velocity profile and the turbulence statistics with and without sand transportation reveal a significant influence of sand movement on the wind field, especially in the dense saltating sand layer ( y/ δ < 0.1). The ensemble-averaged streamwise velocity profile of sand particles was also evaluated to investigate the velocity lag between the sand and the wind. This study would be helpful in improving the understanding of interactions between the wind and the wind-blown sand.


    Institute of Scientific and Technical Information of China (English)

    LI Dan-xun; LIN Qiu-sheng; ZHONG Qiang; WANG Xing-kui


    Sediment-laden flow measurement with Particle Tracking Velocimetry (PTV) introduces a series of finite-sized sampling bins along the vertical of the flow.Instantaneous velocities are collected at each bin and a significantly large sample is established to evaluate mean and root mean square (rms) velocities of the flow.Due to the presence of concentration gradient,the established sample for the solid phase inv(o)lves more data from the lower part of the sampling bin than from the upper part.The concentration effect causes bias errors in the measured mean and rms velocities when velocity varies across the bin.These bias errors are analytically quantified in this study based on simplified linear velocity and concentration distributions.Typical bulk flow characteristics from sediment-laden flow measurements are used to demonstrate rough estimation of the error magnitude.Results indicate that the mean velocity is underestimated while the rms velocity is overestimated in the ensemble-averaged measurement.The extent of deviation is commensurate with the bin size and the rate of concentration gradient.Procedures are proposed to assist determining an appropriate sampling bin size in certain error limits.

  10. Fiber tracking algorithm in combined PIV/PTV measurement of fiber suspension flow (United States)

    Hoseini, Afshin Abbasi; Zavareh, Zahra; Lundell, Fredrik; Anderson, Helge I.


    A new algorithm for fiber tracking in combined PIV/PTV measurement of fiber suspension flow is proposed based on SOM neural network and is examined by synthetic images of fibers showing 2D suspension flows. There is a new idea in the algorithm to take the orientation of fibers into account for matching as well as their position. In two-phase PIV measurements of fiber-laded suspension flows, fiber tracking has a key role together with PIV measurement of fluid phase. The essential parts of fiber tracking are to correctly identify and match fibers in successive images. The development of a method in order to determine the position and orientation of fibers using steerable filter with a reasonable accuracy have already been done, [3]. The present study is concentrated in the development of an algorithm for pairing fibers in consecutive images. The method used is based on the SOM neural network that finds most likely matching link in images on the basis of feature extraction and clustering. The fundamental concept is finding the corresponding fibers with the nearest characteristics, position and angle in images. It improves not only the robustness against loss-of-pair fibers between two image frames but also reliable matching at large numbers of dispersed fibers image using one more characteristics of fibers in image, namely their orientation, in addition to their coordinate vector.

  11. How many fish in a tank? Constructing an automated fish counting system by using PTV analysis (United States)

    Abe, S.; Takagi, T.; Takehara, K.; Kimura, N.; Hiraishi, T.; Komeyama, K.; Torisawa, S.; Asaumi, S.


    Because escape from a net cage and mortality are constant problems in fish farming, health control and management of facilities are important in aquaculture. In particular, the development of an accurate fish counting system has been strongly desired for the Pacific Bluefin tuna farming industry owing to the high market value of these fish. The current fish counting method, which involves human counting, results in poor accuracy; moreover, the method is cumbersome because the aquaculture net cage is so large that fish can only be counted when they move to another net cage. Therefore, we have developed an automated fish counting system by applying particle tracking velocimetry (PTV) analysis to a shoal of swimming fish inside a net cage. In essence, we treated the swimming fish as tracer particles and estimated the number of fish by analyzing the corresponding motion vectors. The proposed fish counting system comprises two main components: image processing and motion analysis, where the image-processing component abstracts the foreground and the motion analysis component traces the individual's motion. In this study, we developed a Region Extraction and Centroid Computation (RECC) method and a Kalman filter and Chi-square (KC) test for the two main components. To evaluate the efficiency of our method, we constructed a closed system, placed an underwater video camera with a spherical curved lens at the bottom of the tank, and recorded a 360° view of a swimming school of Japanese rice fish (Oryzias latipes). Our study showed that almost all fish could be abstracted by the RECC method and the motion vectors could be calculated by the KC test. The recognition rate was approximately 90% when more than 180 individuals were observed within the frame of the video camera. These results suggest that the presented method has potential application as a fish counting system for industrial aquaculture.

  12. Craniocaudal safety margin calculation based on interfractional changes in tumor motion in lung SBRT assessed with an EPID in cine mode. (United States)

    Ueda, Yoshihiro; Miyazaki, Masayoshi; Nishiyama, Kinji; Suzuki, Osamu; Tsujii, Katsutomo; Miyagi, Ken


    To evaluate setup error and interfractional changes in tumor motion magnitude using an electric portal imaging device in cine mode (EPID cine) during the course of stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC) and to calculate margins to compensate for these variations. Subjects were 28 patients with Stage I NSCLC who underwent SBRT. Respiratory-correlated four-dimensional computed tomography (4D-CT) at simulation was binned into 10 respiratory phases, which provided average intensity projection CT data sets (AIP). On 4D-CT, peak-to-peak motion of the tumor (M-4DCT) in the craniocaudal direction was assessed and the tumor center (mean tumor position [MTP]) of the AIP (MTP-4DCT) was determined. At treatment, the tumor on cone beam CT was registered to that on AIP for patient setup. During three sessions of irradiation, peak-to-peak motion of the tumor (M-cine) and the mean tumor position (MTP-cine) were obtained using EPID cine and in-house software. Based on changes in tumor motion magnitude (∆M) and patient setup error (∆MTP), defined as differences between M-4DCT and M-cine and between MTP-4DCT and MTP-cine, a margin to compensate for these variations was calculated with Stroom's formula. The means (±standard deviation: SD) of M-4DCT and M-cine were 3.1 (±3.4) and 4.0 (±3.6) mm, respectively. The means (±SD) of ∆M and ∆MTP were 0.9 (±1.3) and 0.2 (±2.4) mm, respectively. Internal target volume-planning target volume (ITV-PTV) margins to compensate for ∆M, ∆MTP, and both combined were 3.7, 5.2, and 6.4 mm, respectively. EPID cine is a useful modality for assessing interfractional variations of tumor motion. The ITV-PTV margins to compensate for these variations can be calculated. Copyright © 2012 Elsevier Inc. All rights reserved.

  13. On the rms errors and dynamic ranges of triple- and quadruple-pulse particle tracking velocimetry (PTV) (United States)

    Ding, Liuyang; Adrian, Ronald; Gogineni, Sivaram


    Multi-pulse PTV extends conventional dual-pulse PTV by fitting a polynomial to particle locations measured from three or four pulses in a burst, aiming at more accurately resolving a particle short-period trajectory. Particle velocity and acceleration are then evaluated at an optimal time minimizing rms errors. Numerical simulations were performed to completely study the behaviors of position, velocity, and acceleration rms errors of triple- and quadruple-pulse PTV in a 4-D space spanned by four dimensionless variables - normalized time, normalized displacement, normalized particle locating noise, and acceleration factor. We compared three analysis methods - 3-pulse with quadratic fitting, 4-pulse with cubic fitting and 4-pulse with quadratic least-square fitting. In addition, generalized definitions of dynamic spatial range (DSR) and dynamic velocity range (DVR) are proposed for multi-pulse analyses. We calculated DSR ratios and DVR ratios between the multi-pulse and 2-pulse under various flow conditions and noise levels. It is found that the DSR and DVR could be improved by up to 100 times and 10 times, respectively, when the particle trajectory is strongly curved, deceleration is pronounced, and particle locations are accurately determined. This work is supported by ONR N00014-14-C-0095.

  14. Subject positioning in the BOD POD® only marginally affects measurement of body volume and estimation of percent body fat in young adult men.

    Directory of Open Access Journals (Sweden)

    Maarten W Peeters

    Full Text Available INTRODUCTION: The aim of the study was to evaluate whether subject positioning would affect the measurement of raw body volume, thoracic gas volume, corrected body volume and the resulting percent body fat as assessed by air displacement plethysmography (ADP. METHODS: Twenty-five young adult men (20.7±1.1 y, BMI = 22.5±1.4 kg/m(2 were measured using the BOD POD® system using a measured thoracic gas volume sitting in a 'forward bent' position and sitting up in a straight position in random order. RESULTS: Raw body volume was 58±124 ml (p<0.05 higher in the 'straight' position compared to the 'bent' position. The mean difference in measured thoracic gas volume (bent-straight = -71±211 ml was not statistically significant. Corrected body volume and percent body fat in the bent position consequently were on average 86±122 ml (p<0.05 and 0.5±0.7% (p<0.05 lower than in the straight position respectively. CONCLUSION: Although the differences reached statistical significance, absolute differences are rather small. Subject positioning should be viewed as a factor that may contribute to between-test variability and hence contribute to (inprecision in detecting small individual changes in body composition, rather than a potential source of systematic bias. It therefore may be advisable to pay attention to standardizing subject positioning when tracking small changes in PF are of interest. The cause of the differences is shown not to be related to changes in the volume of isothermal air in the lungs. It is hypothesized and calculated that the observed direction and magnitude of these differences may arise from the surface area artifact which does not take into account that a subject in the bent position exposes more skin to the air in the device therefore potentially creating a larger underestimation of the actual body volume due to the isothermal effect of air close to the skin.

  15. Margin requirements, margin loans, and margin rates: practice and principles


    Peter Fortune


    The Board of Governors of the Federal Reserve System establishes initial margin requirements under Regulations T, U, and X. Recent margin loan increases, both in aggregate value and relative to market capitalization, have rekindled the debate about using margin requirements as an instrument to affect the prices of common stocks. Proponents of a more active margin requirement policy see the regulations as instruments for affecting the level and volatility of stock prices by influencing investo...

  16. SU-C-BRE-02: BED Vs. Local Control: Radiobiological Effect of Tumor Volume in Monte Carlo (MC) Lung SBRT Planning

    Energy Technology Data Exchange (ETDEWEB)

    Pokhrel, D; Badkul, R; Jiang, H; Estes, C; Park, J; Kumar, P; Wang, F [UniversityKansas Medical Center, Kansas City, KS (United States)


    Purpose: SBRT with hypofractionated dose schemata has emerged a compelling treatment modality for medically inoperable early stage lung cancer patients. It requires more accurate dose calculation and treatment delivery technique. This report presents the relationship between tumor control probability(TCP) and size-adjusted biological effective dose(sBED) of tumor volume for MC lung SBRT patients. Methods: Fifteen patients who were treated with MC-based lung SBRT to 50Gy in 5 fractions to PTVV100%=95% were studied. ITVs were delineated on MIP images of 4DCT-scans. PTVs diameter(ITV+5mm margins) ranged from 2.7–4.9cm (mean 3.7cm). Plans were generated using non-coplanar conformal arcs/beams using iPlan XVMC algorithm (BrainLABiPlan ver.4.1.2) for Novalis-TX with HD-MLCs and 6MVSRS(1000MU/min) mode, following RTOG-0813 dosimetric guidelines. To understand the known uncertainties of conventional heterogeneities-corrected/uncorrected pencil beam (PBhete/ PB-homo) algorithms, dose distributions were re-calculated with PBhete/ PB-homo using same beam configurations, MLCs and monitor units. Biologically effective dose(BED10) was computed using LQ-model with α/β=10Gy for meanPTV and meanITV. BED10-c*L, gave size-adjusted BED(sBED), where c=10Gy/cm and L=PTV diameter in centimeter. The TCP model was adopted from Ohri et al.(IJROBP, 2012): TCP = exp[sBEDTCD50]/ k /(1.0 + exp[sBED-TCD50]/k), where k=31Gy corresponding to TCD50=0Gy; and more realistic MC-based TCP was computed for PTV(V99%). Results: Mean PTV PB-hete TCP value was 6% higher, but, mean PTV PB-homo TCP value was 4% lower compared to mean PTV MC TCP. Mean ITV PB-hete/PB-homo TCP values were comparable (within ±3.0%) to mean ITV MC TCP. The mean PTV(V99%)had BED10=90.9±3.7%(median=92.2%),sBED=54.1±8.2%(median=53.5%) corresponding to mean MC TCP value of 84.8±3.3%(median=84.9%) at 2- year local control. Conclusion: The TCP model which incorporates BED10 and tumor diameter indicates that radiobiological

  17. Investigating coarse sediment particles transport using PTV and "smart-pebbles" instrumented with inertial sensors (United States)

    Valyrakis, Manousos; Farhadi, Hamed


    This study, reports on the analysis of appropriately designed fluvial experiments investigating the transport of coarse bed material using two approaches: particle tracking velocimetry (PTV) to extract bulk transport parameters and inertia sensor data (via the use of "smart-pebbles") to obtain refined statistics for the transport of the particle. The purpose of this study is to provide further insight on the use of technologies (optical techniques and inertial sensors) that are complementary one to another, towards producing improved estimates of bedload transport in natural rivers. The experiments are conducted in the Water Engineering Lab at the University of Glasgow on a tilting recirculating flume with 90 cm width. Ten different discharges have been implemented in this study. A couple of fake beds, made of well-packed beads of three different sizes have been set up in the flume. The particle motion is captured by two high-speed commercial cameras, responsible for recording the top view covering the full length of the fake beds over which the "smart-pebble" is allowed to be transported. "Smart-pebbles" of four different densities are initially located at the upstream end of the configuration, fully exposed to the instream flow. These are instrumented with appropriate inertial sensors that allow recording the particle's motion, in the Langrangian frame, in high resolution. Specifically, the "smart-pebble" employ a tri-axial gyroscope, magnetometer and accelerometer, which are utilized to obtain minute linear and angular displacements in high frequency (up to 200Hz). However, these are not enough to accurately reconstruct the full trajectory of the particles rolling downstream. To that goal optical methods are used. In particular, by using particle tracking velocimetry data and image processing techniques, the location, orientation and velocities of the "smart-pebble" are derived. Specific consideration is given to appropriately preprocess the obtained video, as

  18. Data fusion for planning target volume and isodose prediction in prostate brachytherapy (United States)

    Nouranian, Saman; Ramezani, Mahdi; Mahdavi, S. Sara; Spadinger, Ingrid; Morris, William J.; Salcudean, Septimiu E.; Abolmaesumi, Purang


    In low-dose prostate brachytherapy treatment, a large number of radioactive seeds is implanted in and adjacent to the prostate gland. Planning of this treatment involves the determination of a Planning Target Volume (PTV), followed by defining the optimal number of seeds, needles and their coordinates for implantation. The two major planning tasks, i.e. PTV determination and seed definition, are associated with inter- and intra-expert variability. Moreover, since these two steps are performed in sequence, the variability is accumulated in the overall treatment plan. In this paper, we introduce a model based on a data fusion technique that enables joint determination of PTV and the minimum Prescribed Isodose (mPD) map. The model captures the correlation between different information modalities consisting of transrectal ultrasound (TRUS) volumes, PTV and isodose contours. We take advantage of joint Independent Component Analysis (jICA) as a linear decomposition technique to obtain a set of joint components that optimally describe such correlation. We perform a component stability analysis to generate a model with stable parameters that predicts the PTV and isodose contours solely based on a new patient TRUS volume. We propose a framework for both modeling and prediction processes and evaluate it on a dataset of 60 brachytherapy treatment records. We show PTV prediction error of 10:02+/-4:5% and the V100 isodose overlap of 97+/-3:55% with respect to the clinical gold standard.

  19. SU-E-J-164: Estimation of DVH Variation for PTV Due to Interfraction Organ Motion in Prostate VMAT Using Gaussian Error Function

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, C [Ryerson University, Toronto, Ontario (Canada); Jiang, R [Grand River Regional Cancer Center, Kitchener, Ontario (Canada); Chow, J [Princess Margaret Cancer Center, Toronto, ON (Canada)


    Purpose: We developed a method to predict the change of DVH for PTV due to interfraction organ motion in prostate VMAT without repeating the CT scan and treatment planning. The method is based on a pre-calculated patient database with DVH curves of PTV modelled by the Gaussian error function (GEF). Methods: For a group of 30 patients with different prostate sizes, their VMAT plans were recalculated by shifting their PTVs 1 cm with 10 increments in the anterior-posterior, left-right and superior-inferior directions. The DVH curve of PTV in each replan was then fitted by the GEF to determine parameters describing the shape of curve. Information of parameters, varying with the DVH change due to prostate motion for different prostate sizes, was analyzed and stored in a database of a program written by MATLAB. Results: To predict a new DVH for PTV due to prostate interfraction motion, prostate size and shift distance with direction were input to the program. Parameters modelling the DVH for PTV were determined based on the pre-calculated patient dataset. From the new parameters, DVH curves of PTVs with and without considering the prostate motion were plotted for comparison. The program was verified with different prostate cases involving interfraction prostate shifts and replans. Conclusion: Variation of DVH for PTV in prostate VMAT can be predicted using a pre-calculated patient database with DVH curve fitting. The computing time is fast because CT rescan and replan are not required. This quick DVH estimation can help radiation staff to determine if the changed PTV coverage due to prostate shift is tolerable in the treatment. However, it should be noted that the program can only consider prostate interfraction motions along three axes, and is restricted to prostate VMAT plan using the same plan script in the treatment planning system.

  20. Infrared and millimeter waves v.14 millimeter components and techniques, pt.V

    CERN Document Server

    Button, Kenneth J


    Infrared and Millimeter Waves, Volume 14: Millimeter Components and Techniques, Part V is concerned with millimeter-wave guided propagation and integrated circuits. In addition to millimeter-wave planar integrated circuits and subsystems, this book covers transducer configurations and integrated-circuit techniques, antenna arrays, optoelectronic devices, and tunable gyrotrons. Millimeter-wave gallium arsenide (GaAs) IMPATT diodes are also discussed. This monograph is comprised of six chapters and begins with a description of millimeter-wave integrated-circuit transducers, focusing on vario

  1. Digital holographic PTV for complicated flow in a water by two cameras and refractive index-matching method (United States)

    Kuniyasu, Masataka; Aoyagi, Yusuke; Unno, Noriyuki; Satake, Shin-ichi; Yuki, Kazuhisa; Seki, Yohji


    A basic heat transfer promoter such as packed beds of spheres is one of the technologies of the promotion of heat transfer using the turbulent mixture. We carried out 3-D visualization of digital holographic PTV to understand the complicated flow in a sphere-packed pipe (SPP) using a refractive index-matching method with a water used as a working fluid, the spheres was made of MEXFLON, whose refractive index is the same as that of a water. To visualize the detail flow structure around the spheres in water, we performed three-dimensional simultaneous measurements of velocity field in a water flow in the SPP are performed by our proposed holography technique with two cameras. The velocity field by two cameras could obtain finer flow structures than that by one camera.


    Directory of Open Access Journals (Sweden)

    Volodymyr O. Sistuk


    Full Text Available The prospect of training quality improving of bachelors and masters in «Automobile transport» and «Transport technologies» specialties was considered, basing on the use of simulation software in the educational process. A review of the software products market was prepared, with the result of the component PTV VISSIM pre-selection. The simulation model of a real crossroad was developed to demonstrate its capabilities. Based on the analysis of application functions aptness to the city transport network complex objects simulation requirements, the expediency of the solution use during vocational certificate credit courses of students of Transport Faculty of Kryvyi Rih National University was grounded.

  3. Radiosynthesis of novel pitavastatin derivative ([(18) F]PTV-F1) as a tracer for hepatic OATP using a one-pot synthetic procedure. (United States)

    Kimura, Hiroyuki; Yagi, Yusuke; Arimitsu, Kenji; Maeda, Kazuya; Ikejiri, Kazuaki; Takano, Jun-Ichi; Kusuhara, Hiroyuki; Kagawa, Shinya; Ono, Masahiro; Sugiyama, Yuichi; Saji, Hideo


    Pitavastatin is an antihyperlipidemic agent, a potent inhibitor of 3-hydroxymethyl-glutaryl-CoA reductase, which is selectively taken up into the liver mainly via hepatic organic anion transporting polypeptide 1B1 (OATP1B1). OATP1B1 can accept a variety of organic anions, and previous reports indicated that it is responsible for the hepatic clearance of several clinically used anionic drugs. Therefore, the pharmacokinetics and the hepatic distribution of pitavastatin provide an insight into the function of OATP1B1 in humans. For the development of the in vivo evaluation of OATP1B1 function by positron emission tomography imaging, we designed a novel [(18) F]pitavastatin derivative ([(18) F]PTV-F1), in which a [(18) F]fluoroethoxy group is substituted for the [(18) F]fluoro group of [(18) F]pitavastatin, with the aim of convenient radiolabeling protocol and high radiochemical yield. In vitro studies suggested that transport activities of PTV-F1 mediated by OATP1B1 and OATP1B3 were very similar to those of pitavastatin and PTV-F1 was metabolically stable in human liver microsomes. In the radiosynthesis of [(18) F]PTV-F1 from the tosylate precursor, nucleophilic fluorination and subsequent deprotection were performed using a one-pot procedure. [(18) F]PTV-F1 was obtained with a radiochemical yield of 45% ± 3% (n = 3), and the operating time for the radiosynthesis of [(18) F]PTV-F1 is very short (30 minutes) compared with [(18) F]pitavastatin.

  4. Impact of the frequency of online verifications on the patient set-up accuracy and set-up margins

    Directory of Open Access Journals (Sweden)

    Mohamed Adel


    Full Text Available Abstract Purpose The purpose of the study was to evaluate the patient set-up error of different anatomical sites, to estimate the effect of different frequencies of online verifications on the patient set-up accuracy, and to calculate margins to accommodate for the patient set-up error (ICRU set-up margin, SM. Methods and materials Alignment data of 148 patients treated with inversed planned intensity modulated radiotherapy (IMRT or three-dimensional conformal radiotherapy (3D-CRT of the head and neck (n = 31, chest (n = 72, abdomen (n = 15, and pelvis (n = 30 were evaluated. The patient set-up accuracy was assessed using orthogonal megavoltage electronic portal images of 2328 fractions of 173 planning target volumes (PTV. In 25 patients, two PTVs were analyzed where the PTVs were located in different anatomical sites and treated in two different radiotherapy courses. The patient set-up error and the corresponding SM were retrospectively determined assuming no online verification, online verification once a week and online verification every other day. Results The SM could be effectively reduced with increasing frequency of online verifications. However, a significant frequency of relevant set-up errors remained even after online verification every other day. For example, residual set-up errors larger than 5 mm were observed on average in 18% to 27% of all fractions of patients treated in the chest, abdomen and pelvis, and in 10% of fractions of patients treated in the head and neck after online verification every other day. Conclusion In patients where high set-up accuracy is desired, daily online verification is highly recommended.

  5. Marginal prescription equivalent to the isocenter prescription in lung stereotactic body radiotherapy: preliminary study for Japan Clinical Oncology Group trial (JCOG1408) (United States)

    Kawahara, Daisuke; Ozawa, Shuichi; Kimura, Tomoki; Saito, Akito; Nishio, Teiji; Nakashima, Takeo; Ohno, Yoshimi; Murakami, Yuji; Nagata, Yasushi


    A new randomized Phase III trial, the Japan Clinical Oncology Group (JCOG) 1408, which compares two dose fractionations (JCOG 0403 and JCOG 0702) for medically inoperable Stage IA NSCLC or small lung lesions clinically diagnosed as primary lung cancer, involves the introduction of a prescribed dose to the D95% of the planning target volume (PTV) using a superposition/convolution algorithm. Therefore, we must determine the prescribed dose in the D95% prescribing method to begin JCOG1408. JCOG 0702 uses density correction and the D95% prescribing method. However, JCOG 0403 uses no density correction and isocenter- prescribing method. The purpose of this study was to evaluate the prescribed dose to the D95% of the PTV equivalent to a dose of 48 Gy to the isocenter (JCOG 0403) using a superposition algorithm. The peripheral isodose line, which has the highest conformity index, and the D95% of the PTV were analyzed by considering the weighting factor, i.e. the inverse of the difference between the doses obtained using the superposition and Clarkson algorithms. The average dose at the isodose line of the highest conformity index and the D95% of the PTV were 41.5 ± 0.3 and 42.0 ± 0.3 Gy, respectively. The D95% of the PTV had a small correlation with the target volume (r2 = 0.0022) and with the distance between the scatterer and tumor volumes (r2 = 0.19). Thus, the prescribed dose of 48 Gy using the Clarkson algorithm (JCOG0403) was found to be equivalent to the prescribed dose of 42 Gy to the D95% of the PTV using the superposition algorithm. PMID:28115532

  6. 夏季加拿大海盆海冰边缘区声体积后向散射强度研究%Study on volume backscattering strength in summer marginal ice zone of Canada Basin

    Institute of Scientific and Technical Information of China (English)

    刘洪宁; 吕连港; 刘娜; 杨光兵; 姜莹; 杨春梅; 刘宗伟; 林丽娜


    Volume backscatter strength (Sv)is a key parameter for acoustic transmission.Study on volume back-scattering strength in marginal ice zone (MIZ)in the Arctic plays an important role in the knowledge of the Arctic acoustic environment.Based on the investigation during the Sixth Chinese National Arctic Research Expedition in summer 2014,the characteristics of backscatter strength in MIZ are analyzed.The results show that Sv under the open water (ice concentration less than 15%)is significantly higher than that in seawater under the packed ice (ice concentration more than 50%).Ice melt causes increasing of opaque creatures and suspended sediment,and leads to increase of Sv.According to the characteristics of low Sv under the packed ice,the proposal about the parameters of LADCP setting is given.%声信号的体积后向散射强度是声传播过程中一个关键的参数。海冰边缘区的声体积后向散射强度研究对深入认识北极声场环境有着十分重要的意义。本文利用中国第六次北极科学考察获取的数据资料研究了海冰边缘区声体积后向散射强度特性。结果表明:加拿大海盆海冰边缘区是声体积后向散射强度的明显过渡区。无冰海面(海冰密集度小于15%)海洋深层水的声体积后向散射强度明显大于密集海冰区域的海水(海冰密集度大于50%)。讨论了声体积后向散射强度与海冰融化之间的关系,造成融冰区声体积后向散射强度增大的原因是水下悬浮泥沙、浮游生物等悬浮物质增加。根据海冰密集海域的海水后向散射强度弱的特点,对北极下放式声学多普勒测流仪(LADCP)观测的设置提出建议。

  7. Interactions of Copepods with Fractal-Grid Generated Turbulence based on Tomo-PIV and 3D-PTV (United States)

    Sun, Zhengzhong; Krizan, Daniel; Longmire, Ellen


    A copepod escapes from predation by sensing fluid motion caused by the predator. It is thought that the escape reaction is elicited by a threshold value of the maximum principal strain rate (MPSR) in the flow. The present experimental work attempts to investigate and quantify the MPSR threshold value. In the experiment, copepods interact with turbulence generated by a fractal grid in a recirculating channel. The turbulent flow is measured by time-resolved Tomo-PIV, while the copepod motion is tracked simultaneously through 3D-PTV. Escape reactions are detected based on copepod trajectories and velocity vectors, while the surrounding hydrodynamic information is retrieved from the corresponding location in the 3D instantaneous flow field. Measurements are performed at three locations downstream of the fractal grid, such that various turbulence levels can be achieved. Preliminary results show that the number of escape reactions decreases at locations with reduced turbulence levels, where shorter jump distances and smaller change of swimming orientation are exhibited. Detailed quantitative results of MPSR threshold values and the dynamics of copepod escape will be presented. Supported by NSF-IDBR Grant #0852875.

  8. Marginalization of the Youth

    DEFF Research Database (Denmark)

    Jensen, Niels Rosendal


    The article is based on a key note speach in Bielefeld on the subject "welfare state and marginalized youth", focusing upon the high ambition of expanding schooling in Denmark from 9 to 12 years. The unintended effect may be a new kind of marginalization.......The article is based on a key note speach in Bielefeld on the subject "welfare state and marginalized youth", focusing upon the high ambition of expanding schooling in Denmark from 9 to 12 years. The unintended effect may be a new kind of marginalization....

  9. Hypo-Fractionated Conformal Radiation Therapy to the Tumor Bed after Segmental Mastectomy (United States)


    at least 50 patients are available for carnation after 24 months from treatment (based on our original design, with a planned accrual )f volume (PTV) demonstrated; tumor bed in red vasn. PTV in blue, heart in pink , and lung in light green. PTV represents a 1.5-cm margin on tumor

  10. Evaluation of the programmed temperature vaporiser for large-volume injection of biological samples in gas chromatography

    NARCIS (Netherlands)

    van Hout, M.W J; de Zeeuw, R.A; Franke, J.P.; de Jong, G.J.


    The use of a programmed temperature vaporiser (PTV) with a packed liner was evaluated for the injection of large volumes (up to 100 mu l) of plasma extracts in a gas chromatograph. Solvent purity, which is essential when large volumes are injected into the GC system, was determined. Special attentio

  11. Practical Marginalized Multilevel Models. (United States)

    Griswold, Michael E; Swihart, Bruce J; Caffo, Brian S; Zeger, Scott L


    Clustered data analysis is characterized by the need to describe both systematic variation in a mean model and cluster-dependent random variation in an association model. Marginalized multilevel models embrace the robustness and interpretations of a marginal mean model, while retaining the likelihood inference capabilities and flexible dependence structures of a conditional association model. Although there has been increasing recognition of the attractiveness of marginalized multilevel models, there has been a gap in their practical application arising from a lack of readily available estimation procedures. We extend the marginalized multilevel model to allow for nonlinear functions in both the mean and association aspects. We then formulate marginal models through conditional specifications to facilitate estimation with mixed model computational solutions already in place. We illustrate the MMM and approximate MMM approaches on a cerebrovascular deficiency crossover trial using SAS and an epidemiological study on race and visual impairment using R. Datasets, SAS and R code are included as supplemental materials.

  12. Effect of serum testosterone and percent tumor volume on extra-prostatic extension and biochemical recurrence after laparoscopic radical prostatectomy

    Directory of Open Access Journals (Sweden)

    Eu Chang Hwang


    Full Text Available Several studies have revealed that the preoperative serum testosterone and percent tumor volume (PTV predict extra-prostatic extension (EPE and biochemical recurrence (BCR after radical prostatectomy. This study investigated the prognostic significance of serum testosterone and PTV in relation to EPE and BCR after laparoscopic radical prostatectomy (LRP. We reviewed 520 patients who underwent LRP between 2004 and 2012. PTV was determined as the sum of all visually estimated tumor foci in every section. BCR was defined as two consecutive increases in the postoperative prostate-specific antigen (PSA >0.2 ng ml−1 . The threshold for serum total testosterone was 3.0 ng ml−1 . Multivariate logistic regression was used to define the effect of variables on the risk of EPE and BCR. A low serum testosterone (<3.0 ng ml−1 was associated with a high serum PSA, Gleason score, positive core percentage of the prostate biopsy, PTV, and all pathological variables. On multivariate analysis, similar to previous studies, the serum PSA, biopsy positive core percentage, Gleason score, and pathological variables predicted EPE and BCR. In addition, low serum testosterone (<3.0 ng ml−1 , adjusted OR, 8.52; 95% CI, 5.04-14.4, P= 0.001 predicted EPE and PTV (adjusted OR, 1.02; 95% CI, 1.01-1.05, P= 0.046 predicted BCR. In addition to previous predictors of EPE and BCR, low serum testosterone and PTV are valuable predictors of EPE and BCR after LRP.

  13. Ocean margins workshop

    Energy Technology Data Exchange (ETDEWEB)



    The Department of Energy (DOE) is announcing the refocusing of its marine research program to emphasize the study of ocean margins and their role in modulating, controlling, and driving Global Change phenomena. This is a proposal to conduct a workshop that will establish priorities and an implementation plan for a new research initiative by the Department of Energy on the ocean margins. The workshop will be attended by about 70 scientists who specialize in ocean margin research. The workshop will be held in the Norfolk, Virginia area in late June 1990.

  14. "We call ourselves marginalized"

    DEFF Research Database (Denmark)

    Jørgensen, Nanna Jordt


    In recent decades, indigenous knowledge has been added to the environmental education agenda in an attempt to address the marginalization of non-western perspectives. While these efforts are necessary, the debate is often framed in terms of a discourse of victimization that overlooks the agency o...... argue that researchers not only need to pay attention to how certain voices are marginalized in Environmental Education research and practice, but also to how learners as agents respond to, use and negotiate the marginalization of their perspectives....

  15. Indian Ocean margins

    Digital Repository Service at National Institute of Oceanography (India)

    Naqvi, S.W.A.

    The most important biogeochemical transformations and boundary exchanges in the Indian Ocean seem to occur in the northern region, where the processes originating at the land-ocean boundary extend far beyond the continental margins. Exchanges across...

  16. Learning unbelievable marginal probabilities

    CERN Document Server

    Pitkow, Xaq; Miller, Ken D


    Loopy belief propagation performs approximate inference on graphical models with loops. One might hope to compensate for the approximation by adjusting model parameters. Learning algorithms for this purpose have been explored previously, and the claim has been made that every set of locally consistent marginals can arise from belief propagation run on a graphical model. On the contrary, here we show that many probability distributions have marginals that cannot be reached by belief propagation using any set of model parameters or any learning algorithm. We call such marginals `unbelievable.' This problem occurs whenever the Hessian of the Bethe free energy is not positive-definite at the target marginals. All learning algorithms for belief propagation necessarily fail in these cases, producing beliefs or sets of beliefs that may even be worse than the pre-learning approximation. We then show that averaging inaccurate beliefs, each obtained from belief propagation using model parameters perturbed about some le...

  17. Immediately loaded mini dental implants as overdenture retainers: 1-Year cohort study of implant stability and peri-implant marginal bone level. (United States)

    Šćepanović, Miodrag; Todorović, Aleksandar; Marković, Aleksa; Patrnogić, Vesna; Miličić, Biljana; Moufti, Adel M; Mišić, Tijana


    This 1-year cohort study investigated stability and peri-implant marginal bone level of immediately loaded mini dental implants used to retain overdentures. Each of 30 edentulous patients received 4 mini dental implants (1.8 mm × 13 mm) in the interforaminal mandibular region. The implants were immediately loaded with pre-made overdentures. Outcome measures included implant stability and bone resorption. Implant stability was measured using the Periotest Classic(®) device immediately after placement and on the 3rd and 6th weeks and the 4th, 6th and 12th months postoperatively. The peri-implant marginal bone level (PIBL) was evaluated at the implant's mesial and distal sides from the polished platform to the marginal crest. Radiographs were taken using a tailored film holder to reproducibly position the X-ray tube at the 6th week, 4th and 12th months postoperatively. The primary stability (Periotest value, PTV) measured -0.27 ± 3.41 on a scale of -8 to + 50 (lower PTV reflects higher stability). The secondary stability decreased significantly until week 6 (mean PTV = 7.61 ± 7.05) then increased significantly reaching (PTV = 6.17 ± 6.15) at 12 months. The mean PIBL measured -0.40 mm after 1 year of functional loading, with no statistically significant differences at the various follow-ups (p = 0.218). Mini dental implants placed into the interforaminal region could achieve a favorable primary stability for immediate loading. The follow-up Periotest values fluctuated, apparently reflecting the dynamics of bone remodeling, with the implants remaining clinically stable (98.3%) after 1 year of function. The 1-year bone resorption around immediately loaded MDIs is within the clinically acceptable range for standard implants. Copyright © 2014 Elsevier GmbH. All rights reserved.

  18. Dosimetric Evaluation of Individualized Adaptive Motion Margins for Abdominal and Thoracic Tumors

    DEFF Research Database (Denmark)

    Poulsen, Per Rugaard; Cho, Byungchul; Keall, Paul

    Purpose/Objective(s): In motion inclusive radiotherapy, respiratory tumor motion is normally accounted for either by population-based CTV-PTV margins that are parallel to the room coordinate system, or by introduction of an ITV that encompasses the tumor motion in a planning CT scan. While...... the former ignores motion correlation along different axes the latter tends to overestimate the dosimetric consequences of random motion. The purpose of this study was to propose and investigate an individualized adaptive margin approach that accounts for motion correlation while still considering...... minutes: First, a cone-beam CT (CBCT) scan with 600 projections was acquired in 1 minute. The tumor position in the CBCT projections was used to estimate the mean position and covariance matrix of the tumor motion (i.e., tumor motion magnitude and tumor motion axes) during the CBCT acquisition. Next...

  19. Masculinity at the margins

    DEFF Research Database (Denmark)

    Jensen, Sune Qvotrup


    This article analyses how young marginalized ethnic minority men in Denmark react to the othering they are subject to in the media as well as in the social arenas of every day life. The article is based on theoretically informed ethnographic fieldwork among such young men as well as interviews an...

  20. From Borders to Margins

    DEFF Research Database (Denmark)

    Parker, Noel


    upon Deleuze's philosophy to set out an ontology in which the continual reformulation of entities in play in ‘post-international' society can be grasped.  This entails a strategic shift from speaking about the ‘borders' between sovereign states to referring instead to the ‘margins' between a plethora...

  1. Marginally Deformed Starobinsky Gravity

    DEFF Research Database (Denmark)

    Codello, A.; Joergensen, J.; Sannino, Francesco


    We show that quantum-induced marginal deformations of the Starobinsky gravitational action of the form $R^{2(1 -\\alpha)}$, with $R$ the Ricci scalar and $\\alpha$ a positive parameter, smaller than one half, can account for the recent experimental observations by BICEP2 of primordial tensor modes....

  2. "We call ourselves marginalized"

    DEFF Research Database (Denmark)

    Jørgensen, Nanna Jordt


    In recent decades, indigenous knowledge has been added to the environmental education agenda in an attempt to address the marginalization of non-western perspectives. While these efforts are necessary, the debate is often framed in terms of a discourse of victimization that overlooks the agency o...

  3. Distribution of Functional Liver Volume in Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombus in the 1st Branch and Main Trunk Using Single Photon Emission Computed Tomography—Application to Radiation Therapy

    Directory of Open Access Journals (Sweden)

    Akira Ikoma


    Full Text Available Purpose: To analyze the distribution of functional liver volume (FLV in the margin volume (MV surrounding hepatocellular carcinoma (HCC with portal vein tumor thrombus (PVTT before radiation therapy (RT and to verify the safety of single photon emission computed tomography-based three-dimensional conformal radiotherapy (SPECT-B3DCRT by exploring the relation of FLV in MV to radiation-induced liver disease (RILD. Methods and Materials: Clinical target volume (CTV included main tumor and PVTT, and planning target volume (PTV included CTV with a 10 mm margin. MV was defined as PTV–CTV. FLV ratio in MV was calculated as FLV in MV/MV × 100 (%. The two high-dose beams were planned to irradiate FLV as little as possible. Fifty-seven cases of HCC (26/57, 46%; Child–Pugh grade B with PVTT underwent SPECT-B3DCRT which targeted the CTV to a total dose of 45 Gy/18 fractions. The destructive ratio was defined as radiation induced dysfunctional volume/FLV × 100 (%. Results: We observed a significant negative correlation between FLV ratio in MV and CTV (p < 0.001. Three cases with CTVs of 287, 587 and 1184 cm3 experienced transient RILD. The FLV ratio in MV was highest in patients with RILD: nine patients with CTV of 200–300 cm3, three with CTV of 500–600 cm3, and two with CTV of 1100–1200 cm3. The destructive ratio yielded a mean value of 24.2 ± 1.5%. Conclusions: Radiation planning that takes into account the distribution of FLV appears to result in the least possible RILD.

  4. Marangoni-B'enard instability in microgravity: PTV-analysis of the velocimetry data generated during the BAMBI - FOTON-M2 experiment (United States)

    Dehaeck, Sam; Talvy, Samuel; Rednikov, Alexey; Queeckers, Patrick; Colinet, Pierre


    The BAMBI (Bifurcation Anomalies in Marangoni-B'enard Instabilities) experiment has been successfully flown onboard the FOTON-M2 satellite in June 2005. During the 4 days available for the experiment, a 5mm-thick 200 cSt silicone oil layer in a 10x10cm^2 wide container, and in contact with a similarly-sized helium gas layer was heated from "below" and cooled from "above." By varying the heating power applied at each experimental step, a range of temperature differences across the liquid and gas layers was scanned and the onset and evolution of the Marangoni-B'enard instability typical for this type of configuration was examined. The used optical diagnostics were Infrared Thermography of the liquid/gas interface, PTV (multiple views and heights in the liquid layer), Wollaston Interferometry and Electronic Speckle Pattern Interferometry. The present contribution focuses on the velocity results obtained by PTV in the interface plane, and discusses them in relation both with infrared images, and with theory/numerics.

  5. Laboratory investigation of the distribution of travel distance and rest period of sediment particles from PTV data (United States)

    Ferreira, Rui M. L.; Antico, Federica


    We analyze paths of sediment particles on cohesionless granular bet subjected to a turbulent open-channel flow. The key objective is to provide further insights on particle dispersion including resting times. Hence, we focus on the spatial and temporal scale identified by Nikora et al. (2002) as the global range, defined as the particle path composed of many intermediate range paths, i.e with several "starts" and "stops". This requires the calculation of the probability distribution functions of particle travel distances and of rest periods. The experimental work was performed at the Hydraulics Laboratory of IST-UL in a 12.5 m long, 0.405 m wide glass-walled flume recirculating water and sediment through independent circuits. The granular bed was a 4.0 m long and 2.5 cm deep reach filled with 5 mm diameter glass beads packed (with some vibration) to a void fraction of 0.356, typical of random packing. Upstream the mobile bed reach the bed was composed of glued particles to ensure the development of a boundary layer with the same roughness. Laboratory tests were run under conditions of weak beadload transport with Shields parameter (θ) in the range 0.007 to 0.030, Froude numbers (Fr) between 0.630 and 0.950 and boundary Reynolds number (Re_ast) in the range 130 to 300. White-coated particles with 5.0 mm diameter were introduced in the flow 3 m upstream the mobile bed reach. Particle motion was registered from above using a high-speed camera AVT Bonito CL-400 with resolution set to 2320 × 1000 px2 and frame rate of 170 fps. The field of view recorded was 77.0 cm long and 38.0 cm wide, covering almost all the width of the flume. The maximum duration of the runs was 20 min, during which more than 500 particle paths, including resting times, were registered. The video footage was subjected to a PTV (Particle Tracking Velocimetry) developed for the problem at hand. The algorithm includes the application of Gaussian filters and thresholding operations to identify the

  6. Masculinity at the margins

    DEFF Research Database (Denmark)

    Jensen, Sune Qvotrup


    of critique although in a masculinist way. These reactions to othering represent a challenge to researchers interested in intersectionality and gender, because gender is reproduced as a hierarchical form of social differentiation at the same time as racism is both reproduced and resisted.......This article analyses how young marginalized ethnic minority men in Denmark react to the othering they are subject to in the media as well as in the social arenas of every day life. The article is based on theoretically informed ethnographic fieldwork among such young men as well as interviews...... and other types of material. Taking the concepts of othering, intersectionality and marginality as point of departure the article analyses how these young men experience othering and how they react to it. One type of reaction, described as stylization, relies on accentuating the latently positive symbolic...

  7. Actively stressed marginal networks

    CERN Document Server

    Sheinman, M; MacKintosh, F C


    We study the effects of motor-generated stresses in disordered three dimensional fiber networks using a combination of a mean-field, effective medium theory, scaling analysis and a computational model. We find that motor activity controls the elasticity in an anomalous fashion close to the point of marginal stability by coupling to critical network fluctuations. We also show that motor stresses can stabilize initially floppy networks, extending the range of critical behavior to a broad regime of network connectivities below the marginal point. Away from this regime, or at high stress, motors give rise to a linear increase in stiffness with stress. Finally, we demonstrate that our results are captured by a simple, constitutive scaling relation highlighting the important role of non-affine strain fluctuations as a susceptibility to motor stress.

  8. Actively stressed marginal networks. (United States)

    Sheinman, M; Broedersz, C P; MacKintosh, F C


    We study the effects of motor-generated stresses in disordered three-dimensional fiber networks using a combination of a mean-field theory, scaling analysis, and a computational model. We find that motor activity controls the elasticity in an anomalous fashion close to the point of marginal stability by coupling to critical network fluctuations. We also show that motor stresses can stabilize initially floppy networks, extending the range of critical behavior to a broad regime of network connectivities below the marginal point. Away from this regime, or at high stress, motors give rise to a linear increase in stiffness with stress. Finally, we demonstrate that our results are captured by a simple, constitutive scaling relation highlighting the important role of nonaffine strain fluctuations as a susceptibility to motor stress.

  9. Seismic margin review of the Maine Yankee Atomic Power Station: Fragility analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ravindra, M. K.; Hardy, G. S.; Hashimoto, P. S.; Griffin, M. J.


    This Fragility Analysis is the third of three volumes for the Seismic Margin Review of the Maine Yankee Atomic Power Station. Volume 1 is the Summary Report of the first trial seismic margin review. Volume 2, Systems Analysis, documents the results of the systems screening for the review. The three volumes are part of the Seismic Margins Program initiated in 1984 by the Nuclear Regulatory Commission (NRC) to quantify seismic margins at nuclear power plants. The overall objectives of the trial review are to assess the seismic margins of a particular pressurized water reactor, and to test the adequacy of this review approach, quantification techniques, and guidelines for performing the review. Results from the trial review will be used to revise the seismic margin methodology and guidelines so that the NRC and industry can readily apply them to assess the inherent quantitative seismic capacity of nuclear power plants.

  10. Iberian Atlantic Margins Group investigates deep structure of ocean margins (United States)

    The Iberian Atlantic Margins Group; Banda, Enric; Torne, Montserrat

    With recent seismic reflection data in hand, investigators for the Iberian Atlantic Margins project are preparing images of the deep continental and oceanic margins of Iberia. In 1993, the IAM group collected near vertical incidence seismic reflection data over a total distance of 3500 km along the North and Western Iberian Margins, Gorringe Bank Region and Gulf of Cadiz (Figure 1). When combined with data on the conjugate margin off Canada, details of the Iberian margin's deep structure should aid in distinguishing rift models and improve understanding of the processes governing the formation of margins.The North Iberian passive continental margin was formed during a Permian to Triassic phase of extension and matured during the early Cretaceous by rotation of the Iberian Peninsula with respect to Eurasia. From the late Cretaceous to the early Oligocene period, Iberia rotated in a counterclockwise direction around an axis located west of Lisbon. The plate boundary between Iberia and Eurasia, which lies along the Pyrenees, follows the north Spanish marginal trough, trends obliquely in the direction of the fossil Bay of Biscay triple junction, and continues along the Azores-Biscay Rise [Sibuet et al., 1994]. Following the NE-SW convergence of Iberia and Eurasia, the reactivation of the North Iberian continental margin resulted in the formation of a marginal trough and accretionary prism [Boillot et al., 1971].

  11. SU-E-T-79: A Study of the Effect of Clinical Tumor Volume Displacement On the Dosage of Post Modified Radical Mastectomy Intensity-Modulated Radiation Therapy Plans for Left-Sided Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, W; Ma, C; Li, D; Wu, F [Cancer Hospital of Shantou University Medical College, Shantou, Guangdong (China)


    Purpose: To explore the effect of clinical tumor volume (CTV) displacement on the dosage of intensity-modulated radiation therapy (IMRT) plans for left-sided breast cancer after modified radical mastectomy. Methods: We created 2 sets of IMRT plans based on PTV0.5 and PTV0.7 (with CTV displacement of 0.5cm and 0.7cm respectively) for each of the ten consecutive left-sided breast cancer patients after modified radical mastectomy, and compared the difference in PTV coverage and organ at risk (OAR) sparing between the two groups. And then, we compared the difference in PTV coverage in IMRT plans based on PTV0.5 between the group with properly estimated CTV displacement (presuming the actual CTV displacement was 0.5cm) and the one with underestimated CTV displacement (presuming the actual CTV displacement was 0.7cm). The difference in results between the corresponding two groups was compared using paired-sample t-test. P values less than 0.05 were considered statistically significant. Results: IMRT plans derived from PTV0.5 had more homogenous PTV coverage, and less heart, left lung, right breast, right lung, left humeral head and B-P radiation exposure, as well as less total Mu as compared with the ones stemmed from PTV0.7 (all p<0.05). IMRT plans with appropriate estimation of CTV displacement had better PTV coverage compared with the ones with underestimated CTV displacement (all p<0.01). Conclusion: The IMRT plans with smaller CTV displacement in post modified radical mastectomy radiotherapy for left-sided breast cancer has dosimetrical advantages over the ones with larger CTV displacement. Underestimation of CTV displacement can lead to significant reduction of PTV coverage. Individually quantifying and minimizing CTV displacement can significantly improve PTV coverage and OAR (including heart and left lung) sparing. This work was supported by the Medical Scientific Research Foundation of Guangdong Procvince (A2014455 to Changchun Ma)

  12. Evaluation of dose-volume histogram parameters (V20 and mean dose) in lung cancer adaptive radiotherapy with design of composite lung volumes (ITV; Evaluacion de parametros del histograma dosis-volumen (V20 y dosis media) en radioterapia adaptada de cancer de pulmon con diseno de volumenes pulmonares compuestos (Internal Target Volume, ITV)

    Energy Technology Data Exchange (ETDEWEB)

    Monroy Anton, J. L.; Solar Tortosa, M.; Lopez Munoz, M.; Navarro Bergada, A.; Estornell gualde, M. A.; Melchor Iniguez, M.


    Physiological respiratory motion is a challenge in external radiotherapy for lung tumors. In adaptive radiotherapy, changing position of the target volume should be reflected in the simulation procedure and taken into account in the design of volumes for CTV/PTV proper coverage. This may be achieved through the design of an Internal Target Volume (ITV) as indicated in ICRU-62. However, the Dose-Volume Histogram (DVH) evaluation of the doses received by the healthy lung may vary in the case of designing a single lung volume, compared to the composite lung volume obtained with the fusion of normal breathing, inspiration and expiration (ITV{sub l}ung). (Author)

  13. Marginally Stable Nuclear Burning (United States)

    Strohmayer, Tod E.; Altamirano, D.


    Thermonuclear X-ray bursts result from unstable nuclear burning of the material accreted on neutron stars in some low mass X-ray binaries (LMXBs). Theory predicts that close to the boundary of stability oscillatory burning can occur. This marginally stable regime has so far been identified in only a small number of sources. We present Rossi X-ray Timing Explorer (RXTE) observations of the bursting, high-inclination LMXB 4U 1323-619 that reveal for the first time in this source the signature of marginally stable burning. The source was observed during two successive RXTE orbits for approximately 5 ksec beginning at 10:14:01 UTC on March 28, 2011. Significant mHz quasi-periodic oscillations (QPO) at a frequency of 8.1 mHz are detected for approximately 1600 s from the beginning of the observation until the occurrence of a thermonuclear X-ray burst at 10:42:22 UTC. The mHz oscillations are not detected following the X-ray burst. The average fractional rms amplitude of the mHz QPOs is 6.4% (3 - 20 keV), and the amplitude increases to about 8% below 10 keV.This phenomenology is strikingly similar to that seen in the LMXB 4U 1636-53. Indeed, the frequency of the mHz QPOs in 4U 1323-619 prior to the X-ray burst is very similar to the transition frequency between mHz QPO and bursts found in 4U 1636-53 by Altamirano et al. (2008). These results strongly suggest that the observed QPOs in 4U 1323-619 are, like those in 4U 1636-53, due to marginally stable nuclear burning. We also explore the dependence of the energy spectrum on the oscillation phase, and we place the present observations within the context of the spectral evolution of the accretion-powered flux from the source.

  14. Gaussian quantum marginal problem

    CERN Document Server

    Eisert, J; Sanders, B C; Tyc, T


    The quantum marginal problem asks what local spectra are consistent with a given state of a composite quantum system. This setting, also referred to as the question of the compatibility of local spectra, has several applications in quantum information theory. Here, we introduce the analogue of this statement for Gaussian states for any number of modes, and solve it in generality, for pure and mixed states, both concerning necessary and sufficient conditions. Formally, our result can be viewed as an analogue of the Sing-Thompson Theorem (respectively Horn's Lemma), characterizing the relationship between main diagonal elements and singular values of a complex matrix: We find necessary and sufficient conditions for vectors (d1, ..., dn) and (c1, ..., cn) to be the symplectic eigenvalues and symplectic main diagonal elements of a strictly positive real matrix, respectively. More physically speaking, this result determines what local temperatures or entropies are consistent with a pure or mixed Gaussian state of ...

  15. Continental margin sedimentation: from sediment transport to sequence stratigraphy (United States)

    Nittrouer, Charles A.; Austin, James A.; Field, Michael E.; Kravitz, Joseph H.; Syvitski, James P.M.; Wiberg, Patricia L.; Nittrouer, Charles A.; Austin, James A.; Field, Michael E.; Kravitz, Joseph H.; Syvitski, James P. M.; Wiberg, Patricia L.


    This volume on continental margin sedimentation brings together an expert editorial and contributor team to create a state-of-the-art resource. Taking a global perspective, the book spans a range of timescales and content, ranging from how oceans transport particles, to how thick rock sequences are formed on continental margins. - Summarizes and integrates our understanding of sedimentary processes and strata associated with fluvial dispersal systems on continental shelves and slopes - Explores timescales ranging from particle transport at one extreme, to deep burial at the other - Insights are presented for margins in general, and with focus on a tectonically active margin (northern California) and a passive margin (New Jersey), enabling detailed examination of the intricate relationships between a wide suite of sedimentary processes and their preserved stratigraphy - Includes observational studies which document the processes and strata found on particular margins, in addition to numerical models and laboratory experimentation, which provide a quantitative basis for extrapolation in time and space of insights about continental-margin sedimentation - Provides a research resource for scientists studying modern and ancient margins, and an educational text for advanced students in sedimentology and stratigraphy

  16. Prostate and seminal vesicle volume based consideration of prostate cancer patients for treatment with 3D-conformal or intensity-modulated radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Reddy, Nandanuri M. S.; Nori, Dattatreyudu; Chang, Hyesook; Lange, Christopher S.; Ravi, Akkamma [Department of Radiation Oncology, New York Hospital Queens, Flushing, New York 11355 (United States); Department of Radiation Oncology, State University of New York Downstate Medical Center, Brooklyn, New York 11203 (United States); Department of Radiation Oncology, New York Hospital Queens, Flushing, New York 11355 (United States)


    Purpose: The purpose of this article was to determine the suitability of the prostate and seminal vesicle volumes as factors to consider patients for treatment with image-guided 3D-conformal radiation therapy (3D-CRT) or intensity-modulated radiation therapy (IMRT), using common dosimetry parameters as comparison tools. Methods: Dosimetry of 3D and IMRT plans for 48 patients was compared. Volumes of prostate, SV, rectum, and bladder, and prescriptions were the same for both plans. For both 3D and IMRT plans, expansion margins to prostate+SV (CTV) and prostate were 0.5 cm posterior and superior and 1 cm in other dimensions to create PTV and CDPTV, respectively. Six-field 3D plans were prepared retrospectively. For 3D plans, an additional 0.5 cm margin was added to PTV and CDPTV. Prescription for both 3D and IMRT plans was the same: 45 Gy to CTV followed by a 36 Gy boost to prostate. Dosimetry parameters common to 3D and IMRT plans were used for comparison: Mean doses to prostate, CDPTV, SV, rectum, bladder, and femurs; percent volume of rectum and bladder receiving 30 (V30), 50 (V50), and 70 Gy (V70), dose to 30% of rectum and bladder, minimum and maximum point dose to CDPTV, and prescription dose covering 95% of CDPTV (D95). Results: When the data for all patients were combined, mean dose to prostate and CDPTV was higher with 3D than IMRT plans (P<0.01). Mean D95 to CDPTV was the same for 3D and IMRT plans (P>0.2). On average, among all cases, the minimum point dose was less for 3D-CRT plans and the maximum point dose was greater for 3D-CRT than for IMRT (P<0.01). Mean dose to 30% rectum with 3D and IMRT plans was comparable (P>0.1). V30 was less (P<0.01), V50 was the same (P>0.2), and V70 was more (P<0.01) for rectum with 3D than IMRT plans. Mean dose to bladder was less with 3D than IMRT plans (P<0.01). V30 for bladder with 3D plans was less than that of IMRT plans (P<0.01). V50 and V70 for 3D plans were the same for 3D and IMRT plans (P>0.2). Mean dose to femurs

  17. On the Evolution of Glaciated Continental Margins (United States)

    Sverre Laberg, Jan; Rydningen, Tom Arne; Safronova, Polina A.; Forwick, Matthias


    has experienced a high sediment input from paleo-ice streams equal to an average erosion of 0.16 mm/yr in a source area dominated by crystalline rocks while the Troms margin experienced markedly lower input, ~0.03 mm/yr of erosion of crystalline rocks in an low-ice-flow sector of the Fennoscandian Ice Sheet. The slope gradient of the areas of high sediment input, the SW Barents Sea slope and the mid-Norwegian margin is mostly ~1 degree or less and dominated by large glacigenic debris flow deposits, outside Troms the slope is much steeper, up to 15 degrees. Here the relief includes gully-channel systems formed by turbidity currents. Off the western Barents Sea the development of large trough-mouth-fans is related to the spatial stability of paleo-ice streams over repeated peak glacials, offshore Troms smaller trough-mouth-fans implies spatially stable paleo-ice streams also here while more unstable paleo-ice streams was one of the main factors that led to the development of a prograding wedge offshore of mid-Norway. All areas have been affected by small- and large-scale submarine landslides. From a detailed study of the NW Barents Sea margin the deposits from these processes were found to represent up to one quarter of the total volume of sediments.

  18. Dosimetric Advantages of Midventilation Compared With Internal Target Volume for Radiation Therapy of Pancreatic Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Lens, Eelco, E-mail:; Horst, Astrid van der; Versteijne, Eva; Tienhoven, Geertjan van; Bel, Arjan


    Purpose: The midventilation (midV) approach can be used to take respiratory-induced pancreatic tumor motion into account during radiation therapy. In this study, the dosimetric consequences for organs at risk and tumor coverage of using a midV approach compared with using an internal target volume (ITV) were investigated. Methods and Materials: For each of the 18 patients, 2 treatment plans (25 × 2.0 Gy) were created, 1 using an ITV and 1 using a midV approach. The midV dose distribution was blurred using the respiratory-induced motion from 4-dimensional computed tomography. The resulting planning target volume (PTV) coverage for this blurred dose distribution was analyzed; PTV coverage was required to be at least V{sub 95%} >98%. In addition, the change in PTV size and the changes in V{sub 10Gy}, V{sub 20Gy}, V{sub 30Gy}, V{sub 40Gy}, D{sub mean} and D{sub 2cc} for the stomach and for the duodenum were analyzed; differences were tested for significance using the Wilcoxon signed-rank test. Results: Using a midV approach resulted in sufficient target coverage. A highly significant PTV size reduction of 13.9% (P<.001) was observed. Also, all dose parameters for the stomach and duodenum, except the D{sub 2cc} of the duodenum, improved significantly (P≤.002). Conclusions: By using the midV approach to account for respiratory-induced tumor motion, a significant PTV reduction and significant dose reductions to the stomach and to the duodenum can be achieved when irradiating pancreatic tumors.

  19. Workers' marginal costs of commuting

    DEFF Research Database (Denmark)

    van Ommeren, Jos; Fosgerau, Mogens


    This paper applies a dynamic search model to estimate workers' marginal costs of commuting, including monetary and time costs. Using data on workers' job search activity as well as moving behaviour, for the Netherlands, we provide evidence that, on average, workers' marginal costs of one hour...

  20. Visualization of the flow profile inside a thinning filament during capillary breakup of a polymer solution via particle image velocimetry (PIV) and particle tracking velocimetry (PTV)

    CERN Document Server

    Gier, S


    We investigated the flow profile of a polymer solution in a thinning capillary bridge. Fluorescent tracer particles with a diameter of 3$\\mu$m were used to visualize the flow. The cylindrical shape of the filament introduced strong optical abberations that could be corrected for, and we were able to characterize the flow in filaments with a thickness ranging from 150 to 30 $\\mu$m. In the first regime when the filament was still sufficiently large, we used a PIV algorithm to deduce the flow field. At later stages when the number of particles in the observation plane decreased a PTV algorithm was used. The main two results of our measurements are as follows. First, the flow profile at the formation of the cylindrical filament is highly inhomogeneous and there is only flow in the outer parts of the filament. Second, we find that in most parts of the regime, where the temporal radius of the thinning filament can be fitted with an exponential law the flow indeed is purely extensional.

  1. Realistic respiratory motion margins for external beam partial breast irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Conroy, Leigh; Quirk, Sarah [Department of Medical Physics, Tom Baker Cancer Centre, Calgary, Alberta T2N 4N2 (Canada); Department of Physics and Astronomy, University of Calgary, Calgary, Alberta T2N 1N4 (Canada); Smith, Wendy L., E-mail: [Department of Medical Physics, Tom Baker Cancer Centre, Calgary, Alberta T2N 4N2 (Canada); Department of Physics and Astronomy, University of Calgary, Calgary, Alberta T2N 1N4 (Canada); Department of Oncology, University of Calgary, Calgary, Alberta T2N 1N4 (Canada)


    described. It was found that the currently used respiratory margin of 5 mm in partial breast irradiation may be overly conservative for many 3DCRT PBI patients. Amplitude alone was found to be insufficient to determine patient-specific margins: individual respiratory trace shape and baseline drift both contributed to the dosimetric target coverage. With respiratory coaching, individualized respiratory margins smaller than the full extent of motion could reduce planning target volumes while ensuring adequate coverage under respiratory motion.

  2. Desarrollo de un Método de Análisis de Metabolitos de Nitrofuranos en Tejido Animal Empleando el Sistema GC/PTV/EI/MSMS Desarrollo de un Método de Análisis de Metabolitos de Nitrofuranos en Tejido Animal Empleando el Sistema GC/PTV/EI/MSMS

    Directory of Open Access Journals (Sweden)

    Laura Renné Velázquez Chong


    Full Text Available En el análisis de metabolitos de 5-nitrofuranos actualmente se emplean sistemas en fase líquida, acoplados a analizadores de masas/masas LC/MSMS los cuales son muy costosos. En este estudio se presenta un método alternativo en el cual se utiliza un sistema en fase gaseosa, con analizador de masa secuencial de trampa de iones y un sistema de inyección de temperatura programable GC/PTV/EI/MS5, para introducir los metabolitos de 5-nitrofuranos, a baja temperatura y derivatizarlos para evitar la degradación térmica de estos compuestos en el sistema de inyección. La derivatización de los metabolitos con anhídrido heptafl uorobutírico (HFBA en el inyector de temperatura programable (PTV, permite obtener estructuras térmicamente estables y se logra una mayor información estructural. Utilizando este método se obtuvo la caracterización de cuatro derivados heptafl uorobutirilados de metabolitos de nitrofuranos: semicarbazida (SEM, 3-amino-2-oxazolidinona (AOZ, 3-amino-5-morfolinometil-2-oxazolidinona (AMOZ y 1-aminohidantoina (AHD en tejido animal de ganado porcino a un nivel de concentración de 1μg/kg. Currently, liquid phase systems are used in the analysis of metabolites of 5-nitrofuranes, connected to mass/mass LC/MSMS analyzers of which are very expensive. In this studyan alternative method is presented in which a gaseous phase system is used, with an iontrap sequential mass analyzer and a temperature programmable GC/PTV/EI/MS5 injection system, to introduce 5-nitrofuranes metabolites, at low temperature and as derivatized to avoid the thermal degradation of these compounds in the injection system. Thermally stable structures are obtained with by derivitizing the metabolites with heptafluorobutyricanhydride (HFBA in the temperature programmable injection system, and greater structural information is also obtained. Using this method the characterization of four heptafluorobutyrates derivatives of metabolites of 5-nitrofuranes was

  3. Pricing hospital care: Global budgets and marginal pricing strategies. (United States)

    Sutherland, Jason M


    The Canadian province of British Columbia (BC) is adding financial incentives to increase the volume of surgeries provided by hospitals using a marginal pricing approach. The objective of this study is to calculate marginal costs of surgeries based on assumptions regarding hospitals' availability of labor and equipment. This study is based on observational clinical, administrative and financial data generated by hospitals. Hospital inpatient and outpatient discharge summaries from the province are linked with detailed activity-based costing information, stratified by assigned case mix categorizations. To reflect a range of operating constraints governing hospitals' ability to increase their volume of surgeries, a number of scenarios are proposed. Under these scenarios, estimated marginal costs are calculated and compared to prices being offered as incentives to hospitals. Existing data can be used to support alternative strategies for pricing hospital care. Prices for inpatient surgeries do not generate positive margins under a range of operating scenarios. Hip and knee surgeries generate surpluses for hospitals even under the most costly labor conditions and are expected to generate additional volume. In health systems that wish to fine-tune financial incentives, setting prices that create incentives for additional volume should reflect knowledge of hospitals' underlying cost structures. Possible implications of mis-pricing include no response to the incentives or uneven increases in supply. Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

  4. To investigate the dose difference by respiratory motion using overlap volume histogram

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Dong Seok; Kang, Seong Hee; Kim, Dong Su; Kim, Tae Ho; Kim, Kyeong Hyeon; Cho, Min Seok; Suh, Tae Suk [Dept. of Biomedical Engineering, Research Institute of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Seoul (Korea, Republic of)


    Four-dimensional dose (4D dose) which uses deformable image registration (DIR) algorithm from four-dimensional computed tomography (4DCT) images can consider dosimetric effect by respiratory motions. The dose difference between 3D dose and 4D dose can be varied according to geometrical relationship between a planning target volume (PTV) and an organ at risk (OAR). The purpose of this study is to investigate the dose difference between 3D and 4D dose using overlap volume histogram (OVH) which is an indicator that quantifies the geometrical relationship between a PTV and an OAR. The tendency of dose difference variation was verified according to OVH. OVH is seems to be an indicator that has a potential to predict the dose difference between 4D and 3D dose.

  5. Neotectonics in the northern equatorial Brazilian margin (United States)

    Rossetti, Dilce F.; Souza, Lena S. B.; Prado, Renato; Elis, Vagner R.


    An increasing volume of publications has addressed the role of tectonics in inland areas of northern Brazil during the Neogene and Quaternary, despite its location in a passive margin. Hence, northern South America plate in this time interval might have not been as passive as usually regarded. This proposal needs further support, particularly including field data. In this work, we applied an integrated approach to reveal tectonic structures in Miocene and late Quaternary strata in a coastal area of the Amazonas lowland. The investigation, undertaken in Marajó Island, mouth of the Amazonas River, consisted of shallow sub-surface geophysical data including vertical electric sounding and ground penetrating radar. These methods were combined with morphostructural analysis and sedimentological/stratigraphic data from shallow cores and a few outcrops. The results revealed two stratigraphic units, a lower one with Miocene age, and an upper one of Late Pleistocene-Holocene age. An abundance of faults and folds were recorded in the Miocene deposits and, to a minor extent, in overlying Late Pleistocene-Holocene strata. In addition to characterize these structures, we discuss their origin, considering three potential mechanisms: Andean tectonics, gravity tectonics related to sediment loading in the Amazon Fan, and rifting at the continental margin. Amongst these hypotheses, the most likely is that the faults and folds recorded in Marajó Island reflect tectonics associated with the history of continental rifting that gave rise to the South Atlantic Ocean. This study supports sediment deposition influenced by transpression and transtension associated with strike-slip divergence along the northern Equatorial Brazilian margin in the Miocene and Late Pleistocene-Holocene. This work records tectonic evidence only for the uppermost few ten of meters of this sedimentary succession. However, available geological data indicate a thickness of up to 6 km, which is remarkably thick for

  6. Impact of 18-fluorodeoxyglucose positron emission tomography on computed tomography defined target volumes in radiation treatment planning of esophageal cancer: reduction in geographic misses with equal inter-observer variability: PET/CT improves esophageal target definition. (United States)

    Schreurs, L M A; Busz, D M; Paardekooper, G M R M; Beukema, J C; Jager, P L; Van der Jagt, E J; van Dam, G M; Groen, H; Plukker, J Th M; Langendijk, J A


    Target volume definition in modern radiotherapy is based on planning computed tomography (CT). So far, 18-fluorodeoxyglucose positron emission tomography (FDG-PET) has not been included in planning modality in volume definition of esophageal cancer. This study evaluates fusion of FDG-PET and CT in patients with esophageal cancer in terms of geographic misses and inter-observer variability in volume definition. In 28 esophageal cancer patients, gross, clinical and planning tumor volumes (GTV; CTV; PTV) were defined on planning CT by three radiation oncologists. After software-based emission tomography and computed tomography (PET/CT) fusion, tumor delineations were redefined by the same radiation-oncologists. Concordance indexes (CCI's) for CT and PET/CT based GTV, CTV and PTV were calculated for each pair of observers. Incorporation of PET/CT modified tumor delineation in 17/28 subjects (61%) in cranial and/or caudal direction. Mean concordance indexes for CT-based CTV and PTV were 72 (55-86)% and 77 (61-88)%, respectively, vs. 72 (47-99)% and 76 (54-87)% for PET/CT-based CTV and PTV. Paired analyses showed no significant difference in CCI between CT and PET/CT. Combining FDG-PET and CT may improve target volume definition with less geographic misses, but without significant effects on inter-observer variability in esophageal cancer.

  7. Comparison between margin-growing algorithms in radiotherapy software environments. (United States)

    Smith, D W; Morgan, A M; Pooler, A M; Thwaites, D I


    Margin-growing algorithms are commonly used tools that are available within virtual simulation and treatment planning software. We report on the accuracy of the margin-growing algorithms available in six commercially available radiotherapy software environments. A phantom containing two differently sized spheres and two rods (one level and one inclined) was constructed and scanned by CT with 1.25 mm, 2.5 mm, 3.75 mm and 5 mm slice thicknesses. The objects were outlined on a GE Advantage Simulator, and the outlined volumes recorded. Images and structures were transferred to MasterPlan, Xio, Pinnacle, Eclipse and Prosoma, where imported volumes were recorded. The contours on each system were grown isotropically by 10 mm, 20 mm and 30 mm, and volumes for each grown contour were recorded. Transfer of structure sets created in GE Advantage Simulator to the other software environments showed that the reported volumes of the four structures differ on each system. Results showed no correlation between volume accuracy and slice thickness. In general, margin growth of up to 30 mm for the rods and spheres is shown to be consistent between systems to within 1.33 mm for all slice thicknesses. Slice thickness did not appear to influence the accuracy of margin growth. Although this work highlights apparent differences in the reported volumes grown from the same original structure sets, the significance of this aspect of the planning process needs to weighed against reported intra- and inter-clinician variability in contour definition. It is not unreasonable, however, to expect that software packages should at least be consistent in volume information provided to the user.

  8. Toward optimal organ at risk sparing in complex volumetric modulated arc therapy: An exponential trade-off with target volume dose homogeneity

    Energy Technology Data Exchange (ETDEWEB)

    Tol, Jim P., E-mail:; Dahele, Max; Doornaert, Patricia; Slotman, Ben J.; Verbakel, Wilko F. A. R. [Department of Radiation Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam (Netherlands)


    Purpose: Conventional radiotherapy typically aims for homogenous dose in the planning target volume (PTV) while sparing organs at risk (OAR). The authors quantified and characterized the trade-off between PTV dose inhomogeneity (IH) and OAR sparing in complex head and neck volumetric modulated arc therapy plans. Methods: Thirteen simultaneous integrated boost plans were created per patient, for ten patients. PTV boost{sub (B)}/elective{sub (E)} optimization priorities were systematically increased. IH{sub B} and IH{sub E}, defined as (100% − V95%) + V107%, were evaluated against the average of the mean dose to the combined composite swallowing and combined salivary organs (D-OAR{sub comp}). To investigate the influence of OAR size and position with respect to PTV{sub B/E}, OAR dose was evaluated against a modified Euclidean distance (DM{sub B}/DM{sub E}) between OAR and PTV. Results: Although the achievable D-OAR{sub comp} for a given level of PTV IH differed between patients, excellent logarithmic fits described the D-OAR{sub comp}/IH{sub B} and IH{sub E} relationship in all patients (mean R{sup 2} of 0.98 and 0.97, respectively). Allowing an increase in average IH{sub B} and IH{sub E} over a clinically acceptable range, e.g., from 0.4% ± 0.5% to 2.0% ± 2.0% and 6.9% ± 2.8% to 14.8% ± 2.7%, respectively, corresponded to a decrease in average dose to the composite salivary and swallowing structures from 30.3 ± 6.5 to 23.6 ± 4.7 Gy and 32.5 ± 8.3 to 26.8 ± 9.3 Gy. The increase in PTV{sub E} IH was mainly accounted for by an increase in V107, by on average 5.9%, rather than a reduction in V95, which was on average only 2%. A linear correlation was found between the OAR dose to composite swallowing structures and contralateral parotid and submandibular gland, with DM{sub E} (R{sup 2} = 0.83, 0.88, 0.95). Only mean ipsilateral parotid dose correlated with DM{sub B} (R{sup 2} = 0.87). Conclusions: OAR sparing is highly dependent on the permitted PTV{sub B

  9. Estimating Marginal Returns to Education (United States)

    Carneiro, Pedro; Heckman, James J.; Vytlacil, Edward


    This paper estimates marginal returns to college for individuals induced to enroll in college by different marginal policy changes. The recent instrumental variables literature seeks to estimate this parameter, but in general it does so only under strong assumptions that are tested and found wanting. We show how to utilize economic theory and local instrumental variables estimators to estimate the effect of marginal policy changes. Our empirical analysis shows that returns are higher for individuals with values of unobservables that make them more likely to attend college. We contrast our estimates with IV estimates of the return to schooling. PMID:25110355

  10. Marginal Solutions for the Superstring

    CERN Document Server

    Erler, Theodore


    We construct a class of analytic solutions of WZW-type open superstring field theory describing marginal deformations of a reference D-brane background. The deformations we consider are generated by on-shell vertex operators with vanishing operator products. The superstring solution exhibits an intriguing duality with the corresponding marginal solution of the {\\it bosonic} string. In particular, the superstring problem is ``dual'' to the problem of re-expressing the bosonic marginal solution in pure gauge form. This represents the first nonsingular analytic solution of open superstring field theory.

  11. Bridging the Gap between Theory and Practice in Educational Research: Methods at the Margins (United States)

    Winkle-Wagner, Rachelle, Ed.; Hunter, Cheryl A., Ed.; Ortloff, Debora Hinderliter, Ed.


    This book provides new ways of thinking about educational processes, using quantitative and qualitative methodologies. Concrete examples of research techniques are provided for those conducting research with marginalized populations or about marginalized ideas. This volume asserts theoretical models related to research methods and the study of…

  12. Volcanic passive margins: another way to break up continents. (United States)

    Geoffroy, L; Burov, E B; Werner, P


    Two major types of passive margins are recognized, i.e. volcanic and non-volcanic, without proposing distinctive mechanisms for their formation. Volcanic passive margins are associated with the extrusion and intrusion of large volumes of magma, predominantly mafic, and represent distinctive features of Larges Igneous Provinces, in which regional fissural volcanism predates localized syn-magmatic break-up of the lithosphere. In contrast with non-volcanic margins, continentward-dipping detachment faults accommodate crustal necking at both conjugate volcanic margins. These faults root on a two-layer deformed ductile crust that appears to be partly of igneous nature. This lower crust is exhumed up to the bottom of the syn-extension extrusives at the outer parts of the margin. Our numerical modelling suggests that strengthening of deep continental crust during early magmatic stages provokes a divergent flow of the ductile lithosphere away from a central continental block, which becomes thinner with time due to the flow-induced mechanical erosion acting at its base. Crustal-scale faults dipping continentward are rooted over this flowing material, thus isolating micro-continents within the future oceanic domain. Pure-shear type deformation affects the bulk lithosphere at VPMs until continental breakup, and the geometry of the margin is closely related to the dynamics of an active and melting mantle.

  13. [Sinaloa: the geography of marginalization]. (United States)

    Aguayo Hernandez, J R


    Sinaloa's State Population Program for 1993-98 contains the objective of promoting integration of demographic criteria into the planning process. The action program calls for establishing indicators of economic and social inequality so that conditions of poverty and margination can be identified. To further these goals, the State Population Council used data from the National Population Council project on regional inequality and municipal margination in Mexico to analyze margination at the state level. Nine indicators of educational status, housing conditions, spatial distribution, and income provide information that allows the definition of municipios and regions that should receive priority in economic and social development programs. The index of municipal margination (IMM) is a statistical summary of the nine indicators, which are based on information in the 1990 census. As of March 1990, 9.9% of Sinaloa's population over age 15 was illiterate and 37.4% had incomplete primary education. 91.0% had electricity, but 18.7% lacked indoor toilet facilities and 19.4% had no piped water. 23.7% of houses had dirt floors. 60% of households were crowded, defined as having more than two persons per bedroom. 43.5% of the state population lived in localities with fewer than 5000 inhabitants, where service delivery is difficult and costly. 55.6% of the economically active population was judged to earn less than the amount needed to satisfy essential needs. All except one municipio bordering the Pacific ocean had low or very low indicators of margination, while all those in the sierra had a medium or high degree of margination. Sinaloa's statewide IMM was eighteenth among Mexico's 32 federal entities, with Chiapas showing the highest degree of margination and the Federal District the lowest.

  14. Maximum margin Bayesian network classifiers. (United States)

    Pernkopf, Franz; Wohlmayr, Michael; Tschiatschek, Sebastian


    We present a maximum margin parameter learning algorithm for Bayesian network classifiers using a conjugate gradient (CG) method for optimization. In contrast to previous approaches, we maintain the normalization constraints on the parameters of the Bayesian network during optimization, i.e., the probabilistic interpretation of the model is not lost. This enables us to handle missing features in discriminatively optimized Bayesian networks. In experiments, we compare the classification performance of maximum margin parameter learning to conditional likelihood and maximum likelihood learning approaches. Discriminative parameter learning significantly outperforms generative maximum likelihood estimation for naive Bayes and tree augmented naive Bayes structures on all considered data sets. Furthermore, maximizing the margin dominates the conditional likelihood approach in terms of classification performance in most cases. We provide results for a recently proposed maximum margin optimization approach based on convex relaxation. While the classification results are highly similar, our CG-based optimization is computationally up to orders of magnitude faster. Margin-optimized Bayesian network classifiers achieve classification performance comparable to support vector machines (SVMs) using fewer parameters. Moreover, we show that unanticipated missing feature values during classification can be easily processed by discriminatively optimized Bayesian network classifiers, a case where discriminative classifiers usually require mechanisms to complete unknown feature values in the data first.

  15. Comparison of planning target volumes based on combination of 18F-FDG PET-CT and 4DCT in thoracic esophageal cancer%PET与四维CT图像结合构建胸段食管癌计划靶体积研究

    Institute of Scientific and Technical Information of China (English)

    李彦康; 郭延娈; 张棚; 李建彬


    目的 比较基于三维CT(three-dimensional CT,3DCT)、四维CT (4DCT)与基于正电子发射计算机断层显像(positron emission tomograpay CT,PET-CT)结合4DCT所构建胸段食管癌原发肿瘤计划靶体积(planning target vol-ume,PTV)位置及体积的差异性.方法 选取2012-12-01-2014-02-28在山东省肿瘤医院放疗科序贯完成3DCT、4DCT和脱氧葡萄糖(fluorodeoxyglucose,FDG) PET-CT胸部定位扫描,且PET图像原发肿瘤最大标准化摄取值(max-imum standardized uptake value,SUVmax)≥2.0的18例胸段食管癌患者.将3DCT图像所得大体肿瘤体积(gross tumorvolume,GTV)上下方向外扩30 mm,横向方向外扩5 mm得到临床靶体积(clinical target volume,CTV3D);CTV3D各方向外扩10 mm得到计划靶体积(planning target volume,PTV3D);内肿瘤靶体积(internal target volume,ITV4D)通过4DCT 10个时相CTV获得;将ITV4D各方向外扩5 mm得到PTV4D;基于SUV≥20% SUVmx得到内生物靶体积(inter-nal biological target volume,IBTVPET20%),将ITV4D与IBTVPET20%通过布尔逻辑运算得到ITVPETT;将ITVPT各方向外扩5 mm得到PTV4r.结果 PTV3D显著大于PTV4D和PTVPETT,P值分别为<0.001和0.044;PTVPT显著大于PTV4D,P=0.048.PTV3D对PTVPETT的包含度(degree of inclusion,DI;0.70±0.05)显著大于PTV3D对PTV4D的DI(0.69±0.06),P=0.042;PTV4D对PTV3D的DI(0.96±0.03)与PTVPETT对PTV3D的DI(0.95士0.03)间差异无统计学意义,P=0.118.结论 在构建胸段食管癌靶区时,利用PET与4DCT图像结合不仅改变了肿瘤PTV的大小,而且改变了空间位置及其形状.将二者结合,也许能够为食管癌放疗靶区构建提供借鉴.

  16. In-cylinder flow field in a spark-ignited natural gas engine. 1st Report. In-cylinder flow visualization by PTV; Hibana tenkashiki tennen gas kikan no nenshoshitsunai ni okeru ryudo tokusei. 1. PTV ni yoru ryudoba no kashika

    Energy Technology Data Exchange (ETDEWEB)

    Fukano, Y.; Hisaki, H.; Kida, S. [Osaka Gas Co. Ltd., Osaka (Japan); Kadota, T. [University of Osaka Prefecture, Osaka (Japan). Faculty of Engineering


    In-cylinder flow field in a spark-ignited natural gas engine was investigated by the laser light sheet PTV method, which can analyze flow field in a short time. Using a single-cylinder visualization engine, flow field was measured right below and 10 mm, 20 mm, and 40 mm below cylinder head, at various crank angles in intake, compression, and expansion strokes. The results showed that induction-generated swirl was getting concentric to the cylinder center in compression stroke, and was shifted to the outward radial direction in expansion stroke. Swirl velocity increases with the lapse of time, showing its maximum around 20deg BTDC during compression stroke, and varies from cycle to cycle within {+-}5% to its maximum velocity. Squish velocity shows its inward maximum and outward maximum around 20deg BTDC and 20deg ATDC, respectively, and varies from cycle to cycle within {+-}8% to its maximum outward velocity. The maximum outward squish velocity in expansion stroke is about twice as large as the maximum inward squish velocity in compression stroke. 11 refs.

  17. Profit margins in Japanese retailing

    NARCIS (Netherlands)

    J.C.A. Potjes; A.R. Thurik (Roy)


    textabstractUsing a rich data source, we explain differences and developments in profit margins of medium-sized stores in Japan. We conclude that the protected environment enables the retailer to pass on all operating costs to the customers and to obtain a relatively high basic income. High service

  18. Profit margins in Japanese retailing

    NARCIS (Netherlands)

    J.C.A. Potjes; A.R. Thurik (Roy)


    textabstractUsing a rich data source, we explain differences and developments in profit margins of medium-sized stores in Japan. We conclude that the protected environment enables the retailer to pass on all operating costs to the customers and to obtain a relatively high basic income. High service

  19. Respiration in ocean margin sediments

    NARCIS (Netherlands)

    Andersson, J.H.


    The aim of this thesis was the study of respiration in ocean margin sediments and the assessments of tools needed for this purpose. The first study was on the biological pump and global respiration patterns in the deep ocean using an empirical model based on sediment oxygen consumption data. In this

  20. Respiration in ocean margin sediments

    NARCIS (Netherlands)

    Andersson, J.H.


    The aim of this thesis was the study of respiration in ocean margin sediments and the assessments of tools needed for this purpose. The first study was on the biological pump and global respiration patterns in the deep ocean using an empirical model based on sediment oxygen consumption data.

  1. The Margins of Medieval Manuscripts

    Directory of Open Access Journals (Sweden)

    Nataša Kavčič


    Full Text Available Shortly after the mid-thirteenth century, various images began to fill the margins in both religious and secular texts. Many factors influenced the emergence of this type of manuscript decoration, but it has generally been attributed to the revived interest in nature and the Gothic inclination for humorous and anecdotic detail. After highlighting other possible reasons for the occurrence of marginal illumination, this paper introduces two manuscripts from the Archiepiscopal Archives in Ljubljana. The manuscripts show numerous facial drawings affixed to some of the letters. This article addresses how to interpret such drawings and stresses that they do not necessarily function as symbolic images or images with any specific didactic value. Quite the opposite, these drawings seem not to have any meaning and are oft en merely indications of an illuminator’s sense of humor. Because of their exaggerated facial expressions, these drawings could be perceived as the true predecessors of modern caricature.

  2. Calculation of Lung Cancer Volume of Target Based on Thorax Computed Tomography Images using Active Contour Segmentation Method for Treatment Planning System (United States)

    Patra Yosandha, Fiet; Adi, Kusworo; Edi Widodo, Catur


    In this research, calculation process of the lung cancer volume of target based on computed tomography (CT) thorax images was done. Volume of the target calculation was done in purpose to treatment planning system in radiotherapy. The calculation of the target volume consists of gross tumor volume (GTV), clinical target volume (CTV), planning target volume (PTV) and organs at risk (OAR). The calculation of the target volume was done by adding the target area on each slices and then multiply the result with the slice thickness. Calculations of area using of digital image processing techniques with active contour segmentation method. This segmentation for contouring to obtain the target volume. The calculation of volume produced on each of the targets is 577.2 cm3 for GTV, 769.9 cm3 for CTV, 877.8 cm3 for PTV, 618.7 cm3 for OAR 1, 1,162 cm3 for OAR 2 right, and 1,597 cm3 for OAR 2 left. These values indicate that the image processing techniques developed can be implemented to calculate the lung cancer target volume based on CT thorax images. This research expected to help doctors and medical physicists in determining and contouring the target volume quickly and precisely.

  3. Respiration in ocean margin sediments


    Andersson, J.H.


    The aim of this thesis was the study of respiration in ocean margin sediments and the assessments of tools needed for this purpose. The first study was on the biological pump and global respiration patterns in the deep ocean using an empirical model based on sediment oxygen consumption data. In this thesis the depth dependence of respiration patterns was modelled using a compiled data set of sediment oxygen consumption rates. We showed that the depth relationship can best be described by a do...

  4. Comparison of pencil beam–based homogeneous vs inhomogeneous target dose planning for stereotactic body radiotherapy of peripheral lung tumors through Monte Carlo–based recalculation

    Energy Technology Data Exchange (ETDEWEB)

    Ohtakara, Kazuhiro, E-mail: [Department of Radiation Oncology, Murakami Memorial Hospital, Asahi University, Gifu (Japan); Hoshi, Hiroaki [Department of Radiology, Gifu University Graduate School of Medicine, Gifu (Japan)


    This study was conducted to ascertain whether homogeneous target dose planning is suitable for stereotactic body radiotherapy (SBRT) of peripheral lung cancer under appropriate breath-holding. For 20 peripheral lung tumors, paired dynamic conformal arc plans were generated by only adjusting the leaf margin to the planning target volume (PTV) edge for fulfilling the conditions such that the prescription isodose surface (IDS) encompassing exactly 95% of the PTV (PTV D{sub 95}) corresponds to 95% and 80% IDS, normalized to 100% at the PTV isocenter under a pencil beam (PB) algorithm with radiologic path length correction. These plans were recalculated using the x-ray voxel Monte Carlo (XVMC) algorithm under otherwise identical conditions, and then compared. Lesions abutting the parietal pleura or not were defined as edge or island tumors, respectively, and the influences of the target volume and its location relative to the chest wall on the target dose were examined. The median (range) leaf margin required for the 95% and 80% plans was 3.9 mm (1.3 to 5.0) and −1.2 mm (−1.8 to 0.1), respectively. Notably, the latter was significantly correlated negatively with PTV. In the 80% plans, the PTV D{sub 95} was slightly higher under XVMC, whereas the PTV D{sub 98} was significantly lower, irrespective of the dose calculation algorithm used. Other PTV and all gross tumor volume doses were significantly higher, while the lung doses outside the PTV were slightly lower. The target doses increased as a function of PTV and were significantly lower for island tumors than for edge tumors. In conclusion, inhomogeneous target dose planning using smaller leaf margin for a larger tumor volume was deemed suitable in ensuring more sufficient target dose while slightly reducing lung dose. In addition, more inhomogeneous target dose planning using <80% IDS (e.g., 70%) for PTV covering would be preferable for island tumors.

  5. Margin to CTV in simultaneous irradiation of treatment volumes attache to various anatomical frameworks: The paradigm of the CA. Of prostate in high risk with indication of lymph node irradiation; Margen al CTV en irradiacion simultanea de volumenes de tratamiento adscritos a distintos marcos anatomicos: El paradigma del CA. de prostata de alto riesgo con indicacion de irradiacion ganglionar

    Energy Technology Data Exchange (ETDEWEB)

    Sanz Freire, C. J.; Perez Echaguen, S.; Collado chamorro, P.; Diaz Pascual, V.; Vazquez Galinanes, A.; Ossola Lentati, G. A.


    The triple objective of this work is: 1 check the effect on the positioning of the GGPP of corrections on the position of the prostate in simultaneous irradiation guided through daily image and its relationship with the filling of rectum and bladder 2. check if employees standard margins for CTV GGPP are valid for this technique 3 calculate the necessary extension of the margin to 2. is not verified. (Author)

  6. Influence of V2O5 Addition on Reduction of NO by C3H6 over Pt/V2O5/Al2O3 Monolithic Catalyst

    Institute of Scientific and Technical Information of China (English)

    Kang Shoufang; Jiang Zheng; Yu Junjie; Hao Zhengping


    Pt/V2O5/Al2O3 and Pt/Al2O3 monolithic catalysts were prepared by wet impregnation method, and the influence of V2 O5 addition on the catalytic activity for NO reduction by C3 H6 under lean burn condition was investigated in detail.The results show that Pt/V2O5/Al2O3 has better activity of NO reduction than Pt/Al2O3 , adding V2O5 to Pt catalyst makes the temperature window of NO reduction shift further to a lower temperature region.The activity of NO reduction decreases and there is a similar degree of deactivation over the two catalysts in the presence of SO2 in feed gas.Moreover, adding V2 O5 to Pt catalyst resulted in improvement of resistance to SO2 oxidation, which decreases the emission of sulfate particulate.Thermal aging treatment counteractes the promoting effect of V2O5 on NO reduction.

  7. Margin Requirements and Equity Option Returns

    DEFF Research Database (Denmark)

    Hitzemann, Steffen; Hofmann, Michael; Uhrig-Homburg, Marliese

    In equity option markets, traders face margin requirements both for the options themselves and for hedging-related positions in the underlying stock market. We show that these requirements carry a significant margin premium in the cross-section of equity option returns. The sign of the margin pre...

  8. SU-E-J-119: What Effect Have the Volume Defined in the Alignment Clipbox for Cervical Cancer Using Automatic Registration Methods for Cone- Beam CT Verification?

    Energy Technology Data Exchange (ETDEWEB)

    Wang, W; Yang, H; Wang, Y; Jia, H; Xie, Y [Taizhou Hospital, Wenzhou Medical College, Taizhou, Zhejiang (China)


    Purpose: To investigate the impact of different clipbox volumes with automated registration techniques using commercially available software with on board volumetric imaging(OBI) for treatment verification in cervical cancer patients. Methods: Fifty cervical cancer patients received daily CBCT scans(on-board imaging v1.5 system, Varian Medical Systems) during the first treatment week and weekly thereafter were included this analysis. A total of 450 CBCT scans were registered to the planning CTscan using pelvic clipbox(clipbox-Pelvic) and around PTV clip box(clipbox- PTV). The translations(anterior-posterior, left-right, superior-inferior) and the rotations(yaw, pitch and roll) errors for each matches were recorded. The setup errors and the systematic and random errors for both of the clip-boxes were calculated. Paired Samples t test was used to analysis the differences between clipbox-Pelvic and clipbox-PTV. Results: . The SD of systematic error(σ) was 1.0mm, 2.0mm,3.2mm and 1.9mm,2.3mm, 3.0mm in the AP, LR and SI directions for clipbox-Pelvic and clipbox-PTV, respectively. The average random error(Σ)was 1.7mm, 2.0mm,4.2mm and 1.7mm,3.4mm, 4.4mm in the AP, LR and SI directions for clipbox-Pelvic and clipbox-PTV, respectively. But, only the SI direction was acquired significantly differences between two image registration volumes(p=0.002,p=0.01 for mean and SD). For rotations, the yaw mean/SD and the pitch SD were acquired significantly differences between clipbox-Pelvic and clipbox-PTV. Conclusion: The defined volume for Image registration is important for cervical cancer when 3D/3D match was used. The alignment clipbox can effect the setup errors obtained. Further analysis is need to determine the optimal defined volume to use the image registration in cervical cancer. Conflict of interest: none.

  9. Biomass energy and marginal areas

    Energy Technology Data Exchange (ETDEWEB)

    Chassany, J.P.


    The aim of this study was to analyze the conditions and effects of a possible development of the biomass energy upgrading in uneconomical or not rentable areas. The physical, social and economical characteristics of these regions (in France) are described; then the different types of biomass are presented (agricultural wastes, energetic cultures, forest and land products and residues, food processing effluents, municipal wastes) as well as the various energy process (production of alcohol, methane, thermochemical processes, vegetable oils). The development and the feasability of these processes in marginal areas are finally analyzed taking into account the accessibility of the biomass and the technical and commercial impacts.

  10. Dynamics of the continental margins

    Energy Technology Data Exchange (ETDEWEB)


    On 18--20 June 1990, over 70 oceanographers conducting research in the ocean margins of North America attended a workshop in Virginia Beach, Virginia. The purpose of the workshop was to provide the Department of Energy with recommendations for future research on the exchange of energy-related materials between the coastal and interior ocean and the relationship between the ocean margins and global change. The workshop was designed to optimize the interaction of scientists from specific research disciplines (biology, chemistry, physics and geology) as they developed hypotheses, research questions and topics and implementation plans. The participants were given few restraints on the research they proposed other than realistic time and monetary limits. The interdisciplinary structure of the meeting promoted lively discussion and creative research plans. The meeting was divided into four working groups based on lateral, vertical, air/sea and sediment/water processes. Working papers were prepared and distributed before the meeting. During the meeting the groups revised the papers and added recommendations that appear in this report, which was reviewed by an Executive Committee.

  11. SU-E-T-430: Feasibility Study On Using Overlap Volume Histogram to Predict the Dose Difference by Respiratory Motion

    Energy Technology Data Exchange (ETDEWEB)

    Shin, D; Kang, S; Kim, D; Kim, T; Kim, K; Cho, M; Suh, T [The Catholic University of Korea, Seoul (Korea, Republic of)


    Purpose: The dose difference between three-dimensional dose (3D dose) and 4D dose which considers motion due to respiratory can be varied according to geometrical relationship between planning target volume (PTV) and organ at risk (OAR). The purpose of the study is to investigate the dose difference between 3D and 4D dose using overlap volume histogram (OVH) which is an indicator that quantify geometrical relationship between a PTV and an OAR. Methods: Five liver cancer patients who previously treated stereotactic body radiotherapy (SBRT) were investigated. Four-dimensional computed tomography (4DCT) images were acquired for all patients. ITV-based treatment planning was performed. 3D dose was calculated on the end-exhale phase image as a reference phase image. 4D dose accumulation was implemented from all phase images using dose warping technique used deformable image registration (DIR) algorithm (Horn and Schunck optical flow) in DIRART. In this study OVH was used to quantify geometrical relationship between a PTV and an OAR. OVH between a PTV and a selected OAR was generated for each patient case and compared for all cases. The dose difference between 3D and 4D dose for normal organ was calculated and compared for all cases according to OVH. Results: The 3D and 4D dose difference for OAR was analyzed using dose-volume histogram (DVH). On the basis of a specific point which corresponds to 10% of OAR volume overlapped with expanded PTV, mean dose difference was 34.56% in minimum OVH distance case and 13.36% in maximum OVH distance case. As the OVH distance increased, mean dose difference between 4D and 3D dose was decreased. Conclusion: The tendency of dose difference variation was verified according to OVH. OVH is seems to be indicator that has a potential to predict the dose difference between 4D and 3D dose. This work was supported by the Radiation Technology R&D program (No. 2013M2A2A7043498) and the Mid-career Researcher Program (2014R1A2A1A10050270) through

  12. Volume Entropy

    CERN Document Server

    Astuti, Valerio; Rovelli, Carlo


    Building on a technical result by Brunnemann and Rideout on the spectrum of the Volume operator in Loop Quantum Gravity, we show that the dimension of the space of the quadrivalent states --with finite-volume individual nodes-- describing a region with total volume smaller than $V$, has \\emph{finite} dimension, bounded by $V \\log V$. This allows us to introduce the notion of "volume entropy": the von Neumann entropy associated to the measurement of volume.

  13. Diffusion tensor imaging for target volume definition in glioblastoma multiforme

    Energy Technology Data Exchange (ETDEWEB)

    Berberat, Jatta; Remonda, Luca [Cantonal Hospital, Department of Neuro-radiology, Aarau (Switzerland); McNamara, Jane; Rogers, Susanne [Cantonal Hospital, Department of Radiation Oncology, Aarau (Switzerland); Bodis, Stephan [Cantonal Hospital, Department of Radiation Oncology, Aarau (Switzerland); University Hospital, Department of Radiation Oncology, Zurich (Switzerland)


    Diffusion tensor imaging (DTI) is an MR-based technique that may better detect the peritumoural region than MRI. Our aim was to explore the feasibility of using DTI for target volume delineation in glioblastoma patients. MR tensor tracts and maps of the isotropic (p) and anisotropic (q) components of water diffusion were coregistered with CT in 13 glioblastoma patients. An in-house image processing program was used to analyse water diffusion in each voxel of interest in the region of the tumour. Tumour infiltration was mapped according to validated criteria and contralateral normal brain was used as an internal control. A clinical target volume (CTV) was generated based on the T{sub 1}-weighted image obtained using contrast agent (T{sub 1Gd}), tractography and the infiltration map. This was compared to a conventional T{sub 2}-weighted CTV (T{sub 2}-w CTV). Definition of a diffusion-based CTV that included the adjacent white matter tracts proved highly feasible. A statistically significant difference was detected between the DTI-CTV and T{sub 2}-w CTV volumes (p < 0.005, t = 3.480). As the DTI-CTVs were smaller than the T{sub 2}-w CTVs (tumour plus peritumoural oedema), the pq maps were not simply detecting oedema. Compared to the clinical planning target volume (PTV), the DTI-PTV showed a trend towards volume reduction. These diffusion-based volumes were smaller than conventional volumes, yet still included sites of tumour recurrence. Extending the CTV along the abnormal tensor tracts in order to preserve coverage of the likely routes of dissemination, whilst sparing uninvolved brain, is a rational approach to individualising radiotherapy planning for glioblastoma patients. (orig.) [German] Die Diffusions-Tensor-Bildgebung (DTI) ist eine MR-Technik, die dank der Erfassung des peritumoralen Bereichs eine Verbesserung bezueglich MRI bringt. Unser Ziel war die Pruefung der Machbarkeit der Verwendung der DTI fuer die Zielvolumenabgrenzung fuer Patienten mit

  14. Formation of the volcanic rifted margin off Argentina/Uruguay, South Atlantic (United States)

    Franke, D.; Reichert, C.; Ladage, S.; Schnabel, M.; Schreckenberger, B.; Neben, S.; Hinz, K.


    The Federal Institute for Geosciences and Natural Resources (BGR), Germany has investigated the passive continental margins offshore Argentina and Uruguay since the early 90ies. Numerous marine geophysical surveys have meanwhile established a databasis of more than 25.000 km of regional multi-channel reflection seismic lines, accompanied with magnetic and gravity profiles. These data document that the Early Cretaceous South Atlantic continental break-up and initial sea-floor spreading were accompanied by large-scale, transient volcanism emplacing voluminous extrusives, manifested in the seismic data by huge wedges of seaward dipping reflectors (SDRs). These deeply buried and 60-120 km wide SDRs were emplaced episodically as suggested by at least three superimposed SDRS units. Distinct along-margin variations in the architecture, volume, and width of the SDRs wedges correlate with large scale margin segmentation. We identify at least four domains bounded by the Falkland Fracture Zone/Falkland Transfer, the Colorado Transfer, the Ventana Transfer and the Salado Transfer. The individual transfer zones may have acted as barriers for propagating rifts during the SDR emplacement phase, selectively directing rift segments in left stepping patterns along the western South Atlantic margin. The rift segments are offset systematically in a left stepping pattern along the western South Atlantic margin. Albeit we found extensive variations in the architecture, style and extent of the seaward dipping reflector sequences a general trend is that the largest volumes are emplaced close to the proposed transfer zones and the width of the SDRs wedges decreases northward within the individual margin segments. The different volcano-tectonic architectures of the margin segments and the distribution of the extruded magmas indicates that the emplacement of the volcanic material was controlled by the tectonic setting and the pre-rift lithosphere configuration within individual margin

  15. Performance Evaluation of Portfolios with Margin Requirements


    Hui Ding; Zhongbao Zhou; Helu Xiao; Chaoqun Ma; Wenbin Liu


    In financial markets, short sellers will be required to post margin to cover possible losses in case the prices of the risky assets go up. Only a few studies focus on the optimization and performance evaluation of portfolios in the presence of margin requirements. In this paper, we investigate the theoretical foundation of DEA (data envelopment analysis) approach to evaluate the performance of portfolios with margin requirements from a different perspective. Under the mean-variance framework,...

  16. Impact of (18)F-Fluciclovine PET on Target Volume Definition for Postprostatectomy Salvage Radiotherapy: Initial Findings from a Randomized Trial. (United States)

    Jani, Ashesh B; Schreibmann, Eduard; Rossi, Peter J; Shelton, Joseph; Godette, Karen; Nieh, Peter; Master, Viraj A; Kucuk, Omer; Goodman, Mark; Halkar, Raghuveer; Cooper, Sherrie; Chen, Zhengjia; Schuster, David M


    The purpose of this study was to evaluate the role of the synthetic amino acid PET radiotracer (18)F-fluciclovine in modifying the defined clinical and treatment-planning target volumes in postprostatectomy patients undergoing salvage radiotherapy and to evaluate the resulting dosimetric consequences to surrounding organs at risk. Methods: Ninety-six patients were enrolled in a randomized, prospective intention-to-treat clinical trial for potential salvage radiotherapy for recurrent prostate cancer after prostatectomy. The initial treatment plan was based on the results from conventional abdominopelvic CT and MRI. The 45 patients in the experimental arm also underwent abdominopelvic (18)F-fluciclovine PET/CT, and the images were registered with the conventional images to determine whether the results would modify the initial treatment plan. The 51 patients in the control arm did not undergo (18)F-fluciclovine PET/CT. For each patient, the clinical and treatment-planning target volumes that would have been treated before (18)F-fluciclovine registration were compared with those after registration. For organs at risk (rectum, bladder, and penile bulb), the volumes receiving 40 Gy and 65 Gy before registration were compared with those after registration. Statistical comparisons were made using the paired t test. Acute genitourinary and gastrointestinal toxicity as defined by the Radiation Therapy Oncology Group was compared between the control and experimental arms using the χ(2) test. Results: In 24 cases, radiotherapy was planned to a clinical target volume consisting of the prostate bed alone (CTV) (64.8-66.6 Gy). In 21 cases, radiotherapy was planned to a clinical target volume consisting of the pelvis (CTV1) (45.0 Gy) followed by a boost to the prostate bed (CTV2) (19.8-25.2 Gy). In each case, the respective treatment-planning target volume expansion (PTV, PTV1, or PTV2) was 0.8 cm (0.6 cm posterior). With the exception of PTV2, all postregistration volumes were

  17. Faster Algorithms for Privately Releasing Marginals


    Thaler, Justin R; Ullman, Jonathan Robert; Vadhan, Salil P.


    We study the problem of releasing $k$-way marginals of a database $D \\in (\\{0,1\\}^d)^n$, while preserving differential privacy. The answer to a $k$-way marginal query is the fraction of $D$'s records $x \\in \\{0,1\\}^d$ with a given value in each of a given set of up to $k$ columns. Marginal queries enable a rich class of statistical analyses of a dataset, and designing efficient algorithms for privately releasing marginal queries has been identified as an important open problem in private data...

  18. Assessment of seismic margin calculation methods

    Energy Technology Data Exchange (ETDEWEB)

    Kennedy, R.P.; Murray, R.C.; Ravindra, M.K.; Reed, J.W.; Stevenson, J.D.


    Seismic margin review of nuclear power plants requires that the High Confidence of Low Probability of Failure (HCLPF) capacity be calculated for certain components. The candidate methods for calculating the HCLPF capacity as recommended by the Expert Panel on Quantification of Seismic Margins are the Conservative Deterministic Failure Margin (CDFM) method and the Fragility Analysis (FA) method. The present study evaluated these two methods using some representative components in order to provide further guidance in conducting seismic margin reviews. It is concluded that either of the two methods could be used for calculating HCLPF capacities. 21 refs., 9 figs., 6 tabs.

  19. [Resection margins in conservative breast cancer surgery]. (United States)

    Medina Fernández, Francisco Javier; Ayllón Terán, María Dolores; Lombardo Galera, María Sagrario; Rioja Torres, Pilar; Bascuñana Estudillo, Guillermo; Rufián Peña, Sebastián


    Conservative breast cancer surgery is facing a new problem: the potential tumour involvement of resection margins. This eventuality has been closely and negatively associated with disease-free survival. Various factors may influence the likelihood of margins being affected, mostly related to the characteristics of the tumour, patient or surgical technique. In the last decade, many studies have attempted to find predictive factors for margin involvement. However, it is currently the new techniques used in the study of margins and tumour localisation that are significantly reducing reoperations in conservative breast cancer surgery. Copyright © 2012 AEC. Published by Elsevier Espana. All rights reserved.

  20. On the evaluation of marginal expected shortfall

    DEFF Research Database (Denmark)

    Caporin, Massimiliano; Santucci de Magistris, Paolo


    In the analysis of systemic risk, Marginal Expected Shortfall may be considered to evaluate the marginal impact of a single stock on the market Expected Shortfall. These quantities are generally computed using log-returns, in particular when there is also a focus on returns conditional distribution....... In this case, the market log-return is only approximately equal to the weighed sum of equities log-returns. We show that the approximation error is large during turbulent market phases, with a subsequent impact on Marginal Expected Shortfall. We then suggest how to improve the evaluation of Marginal Expected...

  1. Optimizing Surgical Margins in Breast Conservation

    Directory of Open Access Journals (Sweden)

    Preya Ananthakrishnan


    Full Text Available Adequate surgical margins in breast-conserving surgery for breast cancer have traditionally been viewed as a predictor of local recurrence rates. There is still no consensus on what constitutes an adequate surgical margin, however it is clear that there is a trade-off between widely clear margins and acceptable cosmesis. Preoperative approaches to plan extent of resection with appropriate margins (in the setting of surgery first as well as after neoadjuvant chemotherapy, include mammography, US, and MRI. Improvements have been made in preoperative lesion localization strategies for surgery, as well as intraoperative specimen assessment, in order to ensure complete removal of imaging findings and facilitate margin clearance. Intraoperative strategies to accurately assess tumor and cavity margins include cavity shave techniques, as well as novel technologies for margin probes. Ablative techniques, including radiofrequency ablation as well as intraoperative radiation, may be used to extend tumor-free margins without resecting additional tissue. Oncoplastic techniques allow for wider resections while maintaining cosmesis and have acceptable local recurrence rates, however often involve surgery on the contralateral breast. As systemic therapy for breast cancer continues to improve, it is unclear what the importance of surgical margins on local control rates will be in the future.

  2. On the Marginal Stability of Glassy Systems (United States)

    Yan, Le; Baity-Jesi, Marco; Müller, Markus; Wyart, Matthieu


    In various glassy systems that are out of equilibrium, like spin glasses and granular packings, the dynamics appears to be critical: avalanches involving almost the whole system could happen. A recent conceptual breakthrough argues that such glassy systems sample the ensemble of marginal stable states, which inevitably results into critical dynamics. However, it is unclear how the marginal stability is dynamically guaranteed. We investigate this marginal stability assumption by studying specifically the critical athermal dynamics of the Sherrington-Kirkpatrick model. We discuss how a pseudo-gap in the density distribution of local fields characterizing the marginal stability arises dynamically.

  3. Quantum bounds for inequalities involving marginal expectation values (United States)

    Wolfe, Elie; Yelin, S. F.


    We review and develop an algorithm to determine arbitrary quantum bounds based on the seminal work of Tsirelson [Lett. Math. Phys.LMPHDY0377-901710.1007/BF00417500 4, 93 (1980)]. The potential of this algorithm is demonstrated by both deriving marginal-involving number-valued quantum bounds and identifying a generalized class of function-valued quantum bounds. Those results facilitate an eight-dimensional volume analysis of quantum mechanics which extends the work of Cabello [Phys. Rev. APLRAAN1050-294710.1103/PhysRevA.72.012113 72, 012113 (2005)]. We contrast the quantum volume defined by these bounds to that of macroscopic locality, defined by the inequalities corresponding to the first level of the hierarchy of Navascués [New J. Phys.1367-263010.1088/1367-2630/10/7/073013 10, 073013 (2008e)], proving our function-valued quantum bounds to be more complete.

  4. Comparisons of treatment optimization directly incorporating random patient setup uncertainty with a margin-based approach. (United States)

    Moore, Joseph A; Gordon, John J; Anscher, Mitchell S; Siebers, Jeffrey V


    The purpose of this study is to incorporate the dosimetric effect of random patient positioning uncertainties directly into a commercial treatment planning system's IMRT plan optimization algorithm through probabilistic treatment planning (PTP) and compare coverage of this method with margin-based planning. In this work, PTP eliminates explicit margins and optimizes directly on the estimated integral treatment dose to determine optimal patient dose in the presence of setup uncertainties. Twenty-eight prostate patient plans adhering to the RTOG-0126 criteria are optimized using both margin-based and PTP methods. Only random errors are considered. For margin-based plans, the planning target volume is created by expanding the clinical target volume (CTV) by 2.1 mm to accommodate the simulated 3 mm random setup uncertainty. Random setup uncertainties are incorporated into IMRT dose evaluation by convolving each beam's incident fluence with a sigma = 3 mm Gaussian prior to dose calculation. PTP optimization uses the convolved fluence to estimate dose to ensure CTV coverage during plan optimization. PTP-based plans are compared to margin-based plans with equal CTV coverage in the presence of setup errors based on dose-volume metrics. The sensitivity of the optimized plans to patient-specific setup uncertainty variations is assessed by evaluating dose metrics for dose distributions corresponding to halving and doubling of the random setup uncertainty used in the optimization. Margin-based and PTP-based plans show similar target coverage. A physician review shows that PTP is preferred for 21 patients, margin-based plans are preferred in 2 patients, no preference is expressed for 1 patient, and both autogenerated plans are rejected for 4 patients. For the PTP-based plans, the average CTV receiving the prescription dose decreases by 0.5%, while the mean dose to the CTV increases by 0.7%. The CTV tumor control probability (TCP) is the same for both methods with the exception

  5. Values and marginal preferences in international business

    NARCIS (Netherlands)

    Maseland, Robbert; van Hoorn, Andre


    In a recent paper in this journal, Maseland and van Hoorn argued that values surveys tend to conflate values and marginal preferences. This assertion has been challenged by Brewer and Venaik, who claim that the wording of most survey items does not suggest that these elicit marginal preferences. Thi

  6. Marginal Utility and Convex Indifference Curves. (United States)

    Jackson, A.A.


    Reviews discussion of the relationship between marginal utility and indifference curves which has been presented in recent issues of "Economics." Concludes that indifference analysis does not embody the assumptions of marginal utility theory and that there is no simple relationship between these concepts that does not entail unacceptable…

  7. The homogeneous marginal utility of income assumption

    NARCIS (Netherlands)

    Demuynck, T.


    We develop a test to verify if every agent from a population of heterogeneous consumers has the same marginal utility of income function. This homogeneous marginal utility of income assumption is often (implicitly) used in applied demand studies because it has nice aggregation properties and facilit

  8. Tumor margin detection using optical biopsy techniques (United States)

    Zhou, Yan; Liu, Cheng-hui; Li, Jiyou; Li, Zhongwu; Zhou, Lixin; Chen, Ke; Pu, Yang; He, Yong; Zhu, Ke; Li, Qingbo; Alfano, Robert R.


    The aim of this study is to use the Resonance Raman (RR) and fluorescence spectroscopic technique for tumor margin detection with high accuracy based on native molecular fingerprints of breast and gastrointestinal (GI) tissues. This tumor margins detection method utilizes advantages of RR spectroscopic technique in situ and in real-time to diagnose tumor changes providing powerful tools for clinical guiding intraoperative margin assessments and postoperative treatments. The tumor margin detection procedures by RR spectroscopy were taken by scanning lesion from center or around tumor region in ex-vivo to find the changes in cancerous tissues with the rim of normal tissues using the native molecular fingerprints. The specimens used to analyze tumor margins include breast and GI carcinoma and normal tissues. The sharp margin of the tumor was found by the changes of RR spectral peaks within 2 mm distance. The result was verified using fluorescence spectra with 300 nm, 320 nm and 340 nm excitation, in a typical specimen of gastric cancerous tissue within a positive margin in comparison with normal gastric tissues. This study demonstrates the potential of RR and fluorescence spectroscopy as new approaches with labeling free to determine the intraoperative margin assessment.

  9. Preoperative pulmonary rehabilitation for marginal-function lung cancer patients. (United States)

    Hashmi, Asra; Baciewicz, Frank A; Soubani, Ayman O; Gadgeel, Shirish M


    Background This study aimed to evaluate the impact of preoperative pulmonary rehabilitation in lung cancer patients undergoing pulmonary resection surgery with marginal lung function. Methods Short-term outcomes of 42 patients with forced expiratory volume in 1 s pulmonary rehabilitation) and group B (receiving pulmonary rehabilitation). In group B, a second set of pulmonary function tests was obtained. Results There were no significant differences in terms of sex, age, race, pathologic stage, operative procedure, or smoking years. Mean forced expiratory volume in 1 s and diffusing capacity for carbon monoxide in group A was 1.40 ± 0.22 L and 10.28 ± 2.64 g∙dL(-1) vs. 1.39 ± 0.13 L and 10.75 ± 2.08 g∙dL(-1) in group B. Group B showed significant improvement in forced expiratory volume in 1 s from 1.39 ± 0.13 to 1.55 ± 0.06 L ( p = 0.02). Mean intensive care unit stay was 6 ± 5 days in group A vs. 9 ± 9 days in group B ( p = 0.22). Mean hospital stay was 10 ± 4 days in group A vs. 14 ± 9 days in group B ( p = 0.31). There was no significant difference in morbidity or mortality between groups. Conclusion Preoperative pulmonary rehabilitation can significantly improve forced expiratory volume in 1 s in some marginal patients undergoing lung cancer resection. However, it does not improve length of stay, morbidity, or mortality.

  10. Statistical Modeling of CTV Motion and Deformation for IMRT of Early-Stage Rectal Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Bondar, Luiza, E-mail: [Department of Radiotherapy, University Medical Center Utrecht, Utrecht (Netherlands); Intven, Martijn; Burbach, J.P. Maarten [Department of Radiotherapy, University Medical Center Utrecht, Utrecht (Netherlands); Budiarto, Eka [Delft Institute of Applied Mathematics, Delft University of Technology, Delft (Netherlands); Kleijnen, Jean-Paul; Philippens, Marielle; Asselen, Bram van; Seravalli, Enrica; Reerink, Onne; Raaymakers, Bas [Department of Radiotherapy, University Medical Center Utrecht, Utrecht (Netherlands)


    Purpose: To derive and validate a statistical model of motion and deformation for the clinical target volume (CTV) of early-stage rectal cancer patients. Methods and Materials: For 16 patients, 4 to 5 magnetic resonance images (MRI) were acquired before each fraction was administered. The CTV was delineated on each MRI. Using a leave-one-out methodology, we constructed a population-based principal component analysis (PCA) model of the CTV motion and deformation of 15 patients, and we tested the model on the left-out patient. The modeling error was calculated as the amount of the CTV motion-deformation of the left-out-patient that could not be explained by the PCA model. Next, the PCA model was used to construct a PCA target volume (PCA-TV) by accumulating motion-deformations simulated by the model. A PCA planning target volume (PTV) was generated by expanding the PCA-TV by uniform margins. The PCA-PTV was compared with uniform and nonuniform CTV-to-PTV margins. To allow comparison, geometric margins were determined to ensure adequate coverage, and the volume difference between the PTV and the daily CTV (CTV-to-PTV volume) was calculated. Results: The modeling error ranged from 0.9 ± 0.5 to 2.9 ± 2.1 mm, corresponding to a reduction of the CTV motion-deformation between 6% and 60% (average, 23% ± 11%). The reduction correlated with the magnitude of the CTV motion-deformation (P<.001, R=0.66). The PCA-TV and the CTV required 2-mm and 7-mm uniform margins, respectively. The nonuniform CTV-to-PTV margins were 4 mm in the left, right, inferior, superior, and posterior directions and 8 mm in the anterior direction. Compared to uniform and nonuniform CTV-to-PTV margins, the PCA-based PTV significantly decreased (P<.001) the average CTV-to-PTV volume by 128 ± 20 mL (49% ± 4%) and by 35 ± 6 mL (20% ± 3.5%), respectively. Conclusions: The CTV motion-deformation of a new patient can be explained by a population-based PCA model. A PCA model

  11. Subduction-driven recycling of continental margin lithosphere. (United States)

    Levander, A; Bezada, M J; Niu, F; Humphreys, E D; Palomeras, I; Thurner, S M; Masy, J; Schmitz, M; Gallart, J; Carbonell, R; Miller, M S


    Whereas subduction recycling of oceanic lithosphere is one of the central themes of plate tectonics, the recycling of continental lithosphere appears to be far more complicated and less well understood. Delamination and convective downwelling are two widely recognized processes invoked to explain the removal of lithospheric mantle under or adjacent to orogenic belts. Here we relate oceanic plate subduction to removal of adjacent continental lithosphere in certain plate tectonic settings. We have developed teleseismic body wave images from dense broadband seismic experiments that show higher than expected volumes of anomalously fast mantle associated with the subducted Atlantic slab under northeastern South America and the Alboran slab beneath the Gibraltar arc region; the anomalies are under, and are aligned with, the continental margins at depths greater than 200 kilometres. Rayleigh wave analysis finds that the lithospheric mantle under the continental margins is significantly thinner than expected, and that thin lithosphere extends from the orogens adjacent to the subduction zones inland to the edges of nearby cratonic cores. Taking these data together, here we describe a process that can lead to the loss of continental lithosphere adjacent to a subduction zone. Subducting oceanic plates can viscously entrain and remove the bottom of the continental thermal boundary layer lithosphere from adjacent continental margins. This drives surface tectonics and pre-conditions the margins for further deformation by creating topography along the lithosphere-asthenosphere boundary. This can lead to development of secondary downwellings under the continental interior, probably under both South America and the Gibraltar arc, and to delamination of the entire lithospheric mantle, as around the Gibraltar arc. This process reconciles numerous, sometimes mutually exclusive, geodynamic models proposed to explain the complex oceanic-continental tectonics of these subduction zones.

  12. Differences in Radiotherapy Delivery and Outcome Due to Contouring Variation

    DEFF Research Database (Denmark)

    Hollensen, Christian; Persson, Gitte; Højgaard, Liselotte;


    segmentation methods also produce different results. There is no consensus on how to account for the contouring uncertainty, but has been suggested to incorporate it into the planning target volume (PTV) margin. Current recipes for the PTV margin are based on normal distribution assumptions and are more......Gross tumor volume (GTV) delineation is central for radiotherapy planning. It provides the basis of the clinical target volume and, ultimately, the planning target volume which is used for dose optimization. Manual GTV delineations are prone to intra- and inter-observer variation and automatic...

  13. A planning study of radiotherapy dose escalation of PET-active tumour volumes in non-small cell lung cancer patients

    Energy Technology Data Exchange (ETDEWEB)

    Sloth Moeller, Ditte; Hoffmann, Lone (Dept. of Medical Physics, Aarhus Univ. Hospital, Aarhus (Denmark)), e-mail:; Khalil, Azza Ahmed; Marquard Knap, Marianne (Dept. of Oncology, Aarhus Univ. Hospital, Aarhus (Denmark)); Muren, Ludvig Paul (Dept. of Medical Physics, Aarhus Univ. Hospital, Aarhus (Denmark); Dept. of Oncology, Aarhus Univ. Hospital, Aarhus (Denmark))


    Background. Patients with non-small cell lung cancer (NSCLC) have poor prognosis partly because of high local failure rates. Escalating the dose to the tumour may decrease the local failure rates and thereby, improve overall survival, but the risk of complications will limit the possibility to dose-escalate a broad range of patients. Escalating only PET-active areas of the tumour may increase the potential for reaching high doses for a variety of tumour sizes and locations. Material and methods. Ten patients were randomly chosen for a dose escalation planning study. A planning target volume (PTV) was defined on the mid-ventilation scan of a four-dimensional computed tomography (4D-CT) scan and a boost planning target volume (PTV-boost) was defined based on a positron emission tomography computed tomography (PET-CT) scan. Treatment plans were created aiming to reach the highest achievable of 74 Gy, 78 Gy or 82 Gy in 2 Gy per fraction prescribed to the PTV-boost without compromising normal tissue constraints and with the PTV prescribed in all cases a biological equivalent dose in 2 Gy fractions of 66 Gy. Results. Nine of ten patients could be escalated to the highest dose level (82 Gy), while one patient was limited by the oesophagus dose constraint and could only reach 74 Gy. Four patients could be dose-escalated above 82 Gy without compromising normal tissue constraints. Conclusion. Dose-escalating only the PET-active areas of lung tumours to doses of 82 Gy while respecting normal tissue constraints is feasible, also in a series of unselected patients including cases with relatively large tumours

  14. Performance Evaluation of Portfolios with Margin Requirements

    Directory of Open Access Journals (Sweden)

    Hui Ding


    Full Text Available In financial markets, short sellers will be required to post margin to cover possible losses in case the prices of the risky assets go up. Only a few studies focus on the optimization and performance evaluation of portfolios in the presence of margin requirements. In this paper, we investigate the theoretical foundation of DEA (data envelopment analysis approach to evaluate the performance of portfolios with margin requirements from a different perspective. Under the mean-variance framework, we construct the optimization model and portfolio possibility set on considering margin requirements. The convexity of the portfolio possibility set is proved and the concept of efficiency in classical economics is extended to the portfolio case. The DEA models are then developed to evaluate the performance of portfolios with margin requirements. Through the simulations carried out in the end, we show that, with adequate portfolios, DEA can be used as an effective tool in computing the efficiencies of portfolios with margin requirements for the performance evaluation purpose. This study can be viewed as a justification of DEA into performance evaluation of portfolios with margin requirements.

  15. Population and patient-specific target margins for 4D adaptive radiotherapy to account for intra- and inter-fraction variation in lung tumour position (United States)

    Hugo, Geoffrey D.; Yan, Di; Liang, Jian


    In this work, five 4D image-guidance strategies (two population, an offline adaptive and two online strategies) were evaluated that compensated for both inter- and intra-fraction variability such as changes to the baseline tumour position and respiratory pattern. None of the strategies required active motion compensation such as gating or tracking; all strategies simulated a free-breathing-based treatment technique. Online kilovoltage fluoroscopy was acquired for eight patients with lung tumours, and used to construct inter- and intra-fraction tumour position variability models. Planning was performed on a mid-ventilation image acquired from a respiration-correlated CT scan. The blurring effect of tumour position variability was included in the dose calculation by convolution. CTV to PTV margins were calculated for variability in the cranio-caudal direction. A population margin of 9.0 ± 0.7 mm was required to account for setup error and respiration in the study population without the use of image-guidance. The greatest mean margin reduction was introduced by the offline adaptive strategy. A daily online correction strategy produced a small reduction (1.6 mm) in the mean margin from the offline strategy. Adaptively correcting for an inter-fraction change in the respiratory pattern had little effect on margin size due to most patients having only small daily changes in the respiratory pattern. A daily online correction strategy would be useful for patients who exhibit large variations in the daily mean tumour position, while an offline adaptive strategy is more applicable to patients with less variation.

  16. The return of sialic material to the mantle indicated by terrigeneous material subducted at convergent margins (United States)

    von, Huene R.; Scholl, D. W.


    At convergent margins where oceanic crust is subducted beneath continental or island-arc crust, sediment on the igneous oceanic crust divides into an accreted and a subducted fraction. Although the subducted fraction is larger, it is obscured in many seismic reflection records because of its depth and the effects of the overlying complex structure. Volumes of accreted and underthrust sediment were quantified at individual margins and global estimates were made of the terrigeneous debris subducted. Also included were debris from subduction erosion. The estimated volume of terrigeneous material subducted beneath continental and island-arc crust is sufficiently large to significantly affect processes along the plate boundary. The possible volume reaching the mantle could have considerable affect on mantle evolution. ?? 1993.

  17. Exploration of the continental margins of India

    Digital Repository Service at National Institute of Oceanography (India)

    Siddiquie, H.N.; Hashimi, N.H.; Vora, K.H.; Pathak, M.C.

    In mid 1970's the National Institute of Oceanography, Goa, India prepared a plan for systematic regional, geological and geophysical surveys of the continental margins of India. This involved over 75,000 km of underway (bathymetric, side scan sonar...

  18. Mental Depreciation and Marginal Decision Making (United States)

    Heath; Fennema


    We propose that individuals practice "mental depreciation," that is, they implicitly spread the fixed costs of their expenses over time or use. Two studies explore how people spread fixed costs on durable goods. A third study shows that depreciation can lead to two distinct errors in marginal decisions: First, people sometimes invest too much effort to get their money's worth from an expense (e.g., they may use a product a lot to spread the fixed expense across more uses). Second, people sometimes invest too little effort to get their money's worth: When people add a portion of the fixed cost to the current costs, their perceived marginal (i.e., incremental) costs exceed their true marginal costs. In response, they may stop investing because their perceived costs surpass the marginal benefits they are receiving. The latter effect is supported by two field studies that explore real board plan decisions by university students.

  19. Time Safety Margin: Theory and Practice (United States)


    safety plan as the test event approaches. Did the planners miss anything? What doesn’t make sense ? Is it too conservative or not conservative enough? The...seconds of TSM for a 10-degree dive at 150 KTAS, producing inefficiency with excessive margin. Somewhere in the middle, the restriction makes sense , but...412TW-TIH-16-01 TIME SAFETY MARGIN: THEORY AND PRACTICE WILLIAM R. GRAY, III Chief Test Pilot USAF Test Pilot School SEPTEMBER 2016

  20. Marketing margins and agricultural technology in Mozambique

    DEFF Research Database (Denmark)

    Arndt, Channing; Jensen, Henning Tarp; Robinson, Sherman


    Improvements in agricultural productivity and reductions in marketing costs in Mozambique are analysed using a computable general equilibrium (CGE) model. The model incorporates detailed marketing margins and separates household demand for marketed and home-produced goods. Individual simulations...... of improved agricultural technology and lower marketing margins yield welfare gains across the economy. In addition, a combined scenario reveals significant synergy effects, as gains exceed the sum of gains from the individual scenarios. Relative welfare improvements are higher for poor rural households...

  1. Statistical Analysis of Thermal Analysis Margin (United States)

    Garrison, Matthew B.


    NASA Goddard Space Flight Center requires that each project demonstrate a minimum of 5 C margin between temperature predictions and hot and cold flight operational limits. The bounding temperature predictions include worst-case environment and thermal optical properties. The purpose of this work is to: assess how current missions are performing against their pre-launch bounding temperature predictions and suggest any possible changes to the thermal analysis margin rules

  2. SU-E-T-578: On Definition of Minimum and Maximum Dose for Target Volume

    Energy Technology Data Exchange (ETDEWEB)

    Gong, Y; Yu, J; Xiao, Y [Thomas Jefferson University Hospital, Philadelphia, PA (United States)


    Purpose: This study aims to investigate the impact of different minimum and maximum dose definitions in radiotherapy treatment plan quality evaluation criteria by using tumor control probability (TCP) models. Methods: Dosimetric criteria used in RTOG 1308 protocol are used in the investigation. RTOG 1308 is a phase III randomized trial comparing overall survival after photon versus proton chemoradiotherapy for inoperable stage II-IIIB NSCLC. The prescription dose for planning target volume (PTV) is 70Gy. Maximum dose (Dmax) should not exceed 84Gy and minimum dose (Dmin) should not go below 59.5Gy in order for the plan to be “per protocol” (satisfactory).A mathematical model that simulates the characteristics of PTV dose volume histogram (DVH) curve with normalized volume is built. The Dmax and Dmin are noted as percentage volumes Dη% and D(100-δ)%, with η and d ranging from 0 to 3.5. The model includes three straight line sections and goes through four points: D95%= 70Gy, Dη%= 84Gy, D(100-δ)%= 59.5 Gy, and D100%= 0Gy. For each set of η and δ, the TCP value is calculated using the inhomogeneously irradiated tumor logistic model with D50= 74.5Gy and γ50=3.52. Results: TCP varies within 0.9% with η; and δ values between 0 and 1. With η and η varies between 0 and 2, TCP change was up to 2.4%. With η and δ variations from 0 to 3.5, maximum of 8.3% TCP difference is seen. Conclusion: When defined maximum and minimum volume varied more than 2%, significant TCP variations were seen. It is recommended less than 2% volume used in definition of Dmax or Dmin for target dosimetric evaluation criteria. This project was supported by NIH grants U10CA180868, U10CA180822, U24CA180803, U24CA12014 and PA CURE Grant.

  3. Investigating Mechanisms of Marginal Settlement Life Improvement

    Directory of Open Access Journals (Sweden)

    Hamid M. Mohammadi


    Full Text Available The main purpose of this research was to investigate mechanisms to improve marginal settlement life in Koohdasht County in Lorestan province. This research was a sort of the survey studies and a questionnaire was compiled for collection of data. Statistical population of this study was included 1560 households; also sampling method was a sort of random sampling. Number of sample size was estimated 85 households. Questionnaire's reliability was confirmed through computing Cronbach's alpha coefficient which was 0.85. Face validity of questionnaire was confirmed by some Tehran university agricultural extension and education department scientific board members. Also data analyzed by WINspss 11.5. The results of research revealed that marginal area residents had not good financial situation but they undertook great supporting burden and in point of view access to services and life conditions had not good situation. Therefore improvement of life conditions of marginal settlement life such as fundamental infrastructure include communication systems and sanitation offloading system recognized as the most important mechanisms of marginal settlement improvement according to results of priority setting of marginal settlement situation mechanisms. Also the results of factor analysis showed that 7 main mechanisms were be effective in term of marginal settlement life improvement that in order to importance were included servicing and life condition improvement, credit-economic, civil and legal, control and prevention, population and migration control, infrastructures improvement and hygiene situation.

  4. Megavoltage conebeam CT cine as final verification of treatment plan in lung stereotactic body radiotherapy. (United States)

    Kudithipudi, Vijay; Gayou, Olivier; Colonias, Athanasios


    To analyse the clinical impact of megavoltage conebeam computed tomography (MV-CBCT) cine on internal target volume (ITV) coverage in lung stereotactic body radiotherapy (SBRT). One hundred and six patients received lung SBRT. All underwent 4D computed tomography simulation followed by treatment via image guided 3D conformal or intensity modulated radiation. Prior to SBRT, all patients underwent MV-CBCT cine, in which raw projections are displayed as beam's-eye-view fluoroscopic series with the planning target volume (PTV) projected onto each image, enabling verification of tumour motion relative to the PTV and assessment of adequacy of treatment margin. Megavoltage conebeam computed tomography cine was completed 1-2 days prior to SBRT. Four patients (3.8%) had insufficient ITV coverage inferiorly at cine review. All four plans were changed by adding 5 mm on the PTV margin inferiorly. The mean change in PTV volumes was 3.9 cubic centimetres (cc) (range 1.85-6.32 cc). Repeat cine was performed after plan modification to ensure adequate PTV coverage in the modified plans. PTV margin was adequate in the majority of patients with this technique. MV-CBCT cine did show insufficient coverage in a small subset of patients. Insufficient PTV margins may be a function of 4D CT simulation inadequacies or deficiencies in visualizing the ITV inferior border in the full-inhale phase. MV-CBCT cine is a valuable tool for final verification of PTV margins. © 2016 The Royal Australian and New Zealand College of Radiologists.

  5. Evaluation of marginal circumference and marginal thickness changes in precrimped stainless steel crowns, after recrimping

    Directory of Open Access Journals (Sweden)

    Afshar H


    Full Text Available Background and Aim: The need for recrimping precrimped stainless steel crowns by the dentist in clinic is controversial. This study aimed to evaluate the rate of marginal circumference and marginal thickness change of precrimped stainless steel crowns after recrimping. Materials and Methods: In this experimental study, 30 primary photos were taken from margins of 30 S.S.Cs (3M, Ni-Cr related to tooth 85 with a digital camera fixed at a determined distance. Margins of crowns were crimped by 114 and 137 pliers with a controlled force (0.2 N and then 30 secondary photos were taken in the same conditions. The circumference of crown margins in primary (group A and secondary (group B photos were assessed by a digitizer system. Comparing the circumferences of crown margins in primary and secondary photos showed a significant decrease after crimping. Thickness of 30 random points on the crown margins of a crown similar to mentioned cases was measured by SEM (×150. Then similar procedures including taking a primary photo, crimping and taking a secondary photo was done for the sample crown. After significant reduction in margin circumference, thickness of 30 other random points on the crown margin were measured by SEM. Data were analyzed by paired sample t-test with p<0.05 as the limit of significance. Results: The mean marginal circumference of precrimped stainless steel crowns was reduced by 7.3% which was significant (P<0.001. On the other hand the mean marginal thickness of sample stainless steel crown showed 18µ increase. Conclusion: According to the results of this study, marginal circumference of precrimped stainless steel crowns (3M, Ni-Cr showed a significant decrease after crimping. It is concluded that crimping the stainless steel crowns even for precrimped ones seems necessary.

  6. The Role of MRSI in Target Volume Definition for Radiation Therapy of Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Mostafa Robatjazi


    Full Text Available Introduction: Recently, magnetic resonance spectroscopic imaging (MRSI, as a functional imaging method, has been used for clinical target volume definition. In this study, we used this method to define the target volume in prostate radiotherapy. Material and Method: In this study, we used images of 20 prostate cancer cases. MRSI and MRI images were fused with CT images. Then, treatment planning was preformed for each patient using three methods: CT, CT+MRI and CT+MRSI planning. Results: The volumes of MRICTV and MRIPTV were on average 12.83% and 8.97% lower than the corresponding CTCTV and CTPTV volumes, respectively. For MRSI, the CTV and PTV volumes were 21% and 27.41% greater than the corresponding CT-based volumes. Maximum dose to rectum showed a 0.58% increase in MRSI relative to CT, and 1.09% reduction in MRI relative to CT. Maximum dose variation in femoral heads showed a 5.4% increase in MRSI relative to CT and 0.67% reduction in MRI relative to CT. Discussion and Conclusion: Application of MRSI for target volume definition of prostate cancer leads to an increase in this volume in comparison to CT planning alone. In this imaging technique, protocol and resolution should be considered to determine the target volume exactly.

  7. The role of delineation education programs for improving interobserver variability in target volume delineation in gastric cancer. (United States)

    Onal, Cem; Cengiz, Mustafa; Guler, Ozan C; Dolek, Yemliha; Ozkok, Serdar


    To assess whether delineation courses for radiation oncologists improve interobserver variability in target volume delineation for post-operative gastric cancer radiotherapy planning. 29 radiation oncologists delineated target volumes in a gastric cancer patient. An experienced radiation oncologist lectured about delineation based on contouring atlas and delineation recommendations. After the course, the radiation oncologists, blinded to the previous delineation, provided delineation for the same patient. The difference between delineated volumes and reference volumes for pre- and post-course clinical target volume (CTV) were 19.8% (-42.4 to 70.6%) and 12.3% (-12.0 to 27.3%) (p = 0.26), respectively. The planning target volume (PTV) differences pre- and post-course according to the reference volume were 20.5% (-40.7 to 93.7%) and 13.1% (-10.6 to 29.5%) (p = 0.30), respectively. The concordance volumes between the pre- and post-course CTVs and PTVs were 467.1 ± 89.2 vs 597.7 ± 54.6 cm(3) (p target volume changes on toxicity and local control should be evaluated for further studies. Advances in knowledge: This study demonstrated that a delineation course based on current recommendations helped physicians delineate smaller and more homogeneous target volumes. Better target volume delineation allows proper target volume irradiation and preventing unnecessary normal tissue irradiation.

  8. Marginal Space Deep Learning: Efficient Architecture for Volumetric Image Parsing. (United States)

    Ghesu, Florin C; Krubasik, Edward; Georgescu, Bogdan; Singh, Vivek; Yefeng Zheng; Hornegger, Joachim; Comaniciu, Dorin


    Robust and fast solutions for anatomical object detection and segmentation support the entire clinical workflow from diagnosis, patient stratification, therapy planning, intervention and follow-up. Current state-of-the-art techniques for parsing volumetric medical image data are typically based on machine learning methods that exploit large annotated image databases. Two main challenges need to be addressed, these are the efficiency in scanning high-dimensional parametric spaces and the need for representative image features which require significant efforts of manual engineering. We propose a pipeline for object detection and segmentation in the context of volumetric image parsing, solving a two-step learning problem: anatomical pose estimation and boundary delineation. For this task we introduce Marginal Space Deep Learning (MSDL), a novel framework exploiting both the strengths of efficient object parametrization in hierarchical marginal spaces and the automated feature design of Deep Learning (DL) network architectures. In the 3D context, the application of deep learning systems is limited by the very high complexity of the parametrization. More specifically 9 parameters are necessary to describe a restricted affine transformation in 3D, resulting in a prohibitive amount of billions of scanning hypotheses. The mechanism of marginal space learning provides excellent run-time performance by learning classifiers in clustered, high-probability regions in spaces of gradually increasing dimensionality. To further increase computational efficiency and robustness, in our system we learn sparse adaptive data sampling patterns that automatically capture the structure of the input. Given the object localization, we propose a DL-based active shape model to estimate the non-rigid object boundary. Experimental results are presented on the aortic valve in ultrasound using an extensive dataset of 2891 volumes from 869 patients, showing significant improvements of up to 45

  9. Reconstructing Rodinia by Fitting Neoproterozoic Continental Margins (United States)

    Stewart, John H.


    Reconstructions of Phanerozoic tectonic plates can be closely constrained by lithologic correlations across conjugate margins by paleontologic information, by correlation of orogenic belts, by paleomagnetic location of continents, and by ocean floor magmatic stripes. In contrast, Proterozoic reconstructions are hindered by the lack of some of these tools or the lack of their precision. To overcome some of these difficulties, this report focuses on a different method of reconstruction, namely the use of the shape of continents to assemble the supercontinent of Rodinia, much like a jigsaw puzzle. Compared to the vast amount of information available for Phanerozoic systems, such a limited approach for Proterozoic rocks, may seem suspect. However, using the assembly of the southern continents (South America, Africa, India, Arabia, Antarctica, and Australia) as an example, a very tight fit of the continents is apparent and illustrates the power of the jigsaw puzzle method. This report focuses on Neoproterozoic rocks, which are shown on two new detailed geologic maps that constitute the backbone of the study. The report also describes the Neoproterozoic, but younger or older rocks are not discussed or not discussed in detail. The Neoproterozoic continents and continental margins are identified based on the distribution of continental-margin sedimentary and magmatic rocks that define the break-up margins of Rodinia. These Neoproterozoic continental exposures, as well as critical Neo- and Meso-Neoproterozoic tectonic features shown on the two new map compilations, are used to reconstruct the Mesoproterozoic supercontinent of Rodinia. This approach differs from the common approach of using fold belts to define structural features deemed important in the Rodinian reconstruction. Fold belts are difficult to date, and many are significantly younger than the time frame considered here (1,200 to 850 Ma). Identifying Neoproterozoic continental margins, which are primarily

  10. Abrupt plate accelerations shape rifted continental margins (United States)

    Brune, Sascha; Williams, Simon E.; Butterworth, Nathaniel P.; Müller, R. Dietmar


    Rifted margins are formed by persistent stretching of continental lithosphere until breakup is achieved. It is well known that strain-rate-dependent processes control rift evolution, yet quantified extension histories of Earth’s major passive margins have become available only recently. Here we investigate rift kinematics globally by applying a new geotectonic analysis technique to revised global plate reconstructions. We find that rifted margins feature an initial, slow rift phase (less than ten millimetres per year, full rate) and that an abrupt increase of plate divergence introduces a fast rift phase. Plate acceleration takes place before continental rupture and considerable margin area is created during each phase. We reproduce the rapid transition from slow to fast extension using analytical and numerical modelling with constant force boundary conditions. The extension models suggest that the two-phase velocity behaviour is caused by a rift-intrinsic strength-velocity feedback, which can be robustly inferred for diverse lithosphere configurations and rheologies. Our results explain differences between proximal and distal margin areas and demonstrate that abrupt plate acceleration during continental rifting is controlled by the nonlinear decay of the resistive rift strength force. This mechanism provides an explanation for several previously unexplained rapid absolute plate motion changes, offering new insights into the balance of plate driving forces through time.

  11. Theory of margination in confined multicomponent suspensions (United States)

    Henriquez Rivera, Rafael; Sinha, Kushal; Graham, Michael


    In blood flow, leukocytes and platelets tend to segregate near the vessel walls; this is known as margination. Margination of leukocytes and platelets is important in physiological processes, medical diagnostics and drug delivery. A mechanistic theory is developed to describe flow-induced segregation in confined multicomponent suspensions of deformable particles such as blood. The theory captures the essential features of margination by describing it in terms of two key competing processes in these systems at low Reynolds number: wall-induced migration and hydrodynamic pair collisions. The theory also includes the effect of physical properties of the deformable particles and molecular diffusion. Several regimes of segregation are identified, depending on the value of a ``margination parameter'' M. Moreover, there is a critical value of M below which a sharp ``drainage transition'' occurs: one component is completely depleted from the bulk flow to the vicinity of the walls. Direct hydrodynamic simulations also display this transition in suspensions where the components differ in size or flexibility. The developed mechanistic theory leads to substantial insight into the origins of margination and will help in guiding development of new technologies involving multicomponent suspensions. This work was supported by NSF grant CBET-1436082.

  12. Collapse of modern carbonate platform margins

    Energy Technology Data Exchange (ETDEWEB)

    Mullins, H.T.; Hine, A.C.; Gardulski, A.


    Modern carbonate platform margins in the Florida-Bahama region have been viewed as depositional or constructional features. However, recent studies have shown that carbonate escarpments, such as the Blake-Bahama and West Florida Escarpments, are erosional in origin where the platform margins have a scalloped or horse-shoe shape. Seismic reflection data from one of these crescentic features along the west Florida platform margin indicate that it originated by large scale gravity collapse (slump). This collapse structure extends for at least 120 km along the margin and has removed about 350 m of strata as young as early Neogene. Although at least three generations of slope failure are recognized, catastrophic collapse appears to have occurred in the mid-Miocene. Gravitational instability due to high rates of sediment accumulation may have been the triggering mechanism. These data suggest that submarine slumping is an important process in the retreat of limestone escarpments and in the generation of carbonate megabreccia debris flows. Scalloped platform margins occur on satellite images of northern Exuma Sound and Columbus Basin in the Bahamas. The authors suggest that large-scale submarine slumping can cause elongation of structurally controlled intraplatform basins (Exuma South), and produce anomalous horse-shoe shaped basins (Columbus Basin) by mega-collapse processes.

  13. Abrupt plate accelerations shape rifted continental margins. (United States)

    Brune, Sascha; Williams, Simon E; Butterworth, Nathaniel P; Müller, R Dietmar


    Rifted margins are formed by persistent stretching of continental lithosphere until breakup is achieved. It is well known that strain-rate-dependent processes control rift evolution, yet quantified extension histories of Earth's major passive margins have become available only recently. Here we investigate rift kinematics globally by applying a new geotectonic analysis technique to revised global plate reconstructions. We find that rifted margins feature an initial, slow rift phase (less than ten millimetres per year, full rate) and that an abrupt increase of plate divergence introduces a fast rift phase. Plate acceleration takes place before continental rupture and considerable margin area is created during each phase. We reproduce the rapid transition from slow to fast extension using analytical and numerical modelling with constant force boundary conditions. The extension models suggest that the two-phase velocity behaviour is caused by a rift-intrinsic strength--velocity feedback, which can be robustly inferred for diverse lithosphere configurations and rheologies. Our results explain differences between proximal and distal margin areas and demonstrate that abrupt plate acceleration during continental rifting is controlled by the nonlinear decay of the resistive rift strength force. This mechanism provides an explanation for several previously unexplained rapid absolute plate motion changes, offering new insights into the balance of plate driving forces through time.

  14. Fluorescence lifetime spectroscopy for breast cancer margins assessment (United States)

    Gorpas, Dimitris; Fatakdawala, Hussain; Zhang, Yanhong; Bold, Richard; Marcu, Laura


    During breast conserving surgery (BCS), which is the preferred approach to treat most early stage breast cancers, the surgeon attempts to excise the tumor volume, surrounded by thin margin of normal tissue. The intra-operative assessment of cancerous areas is a challenging procedure, with the surgeon usually relying on visual or tactile guidance. This study evaluates whether time-resolved fluorescence spectroscopy (TRFS) presents the potential to address this problem. Point TRFS measurements were obtained from 19 fresh tissue slices (7 patients) and parameters that characterize the transient signals were quantified via constrained least squares deconvolution scheme. Fibrotic tissue (FT, n=69), adipose tissue (AT, n=76), and invasive ductal carcinoma (IDC, n=27) were identified in histology and univariate statistical analysis, followed by multi-comparison test, was applied to the corresponding lifetime data. Significant differentiation between the three tissue types exists at 390 nm and 500 nm bands. The average lifetime is 3.23+/-0.74 ns for AT, 4.21+/-0.83 ns for FT and 4.71+/-0.35 ns (ptissue in real-time and assess tumor margins.

  15. Digital Margins : How spatially and socially marginalized communities deal with digital exclusion

    NARCIS (Netherlands)

    Salemink, Koen


    The increasing importance of the Internet as a means of communication has transformed economies and societies. For spatially and socially marginalized communities, this transformation has resulted in digital exclusion and further marginalization. This book presents a study of two kinds of marginaliz

  16. Marginalization revisited: critical, postmodern, and liberation perspectives. (United States)

    Hall, J M


    Marginalization was advocated by Hall, Stevens, and Meleis in 1994 as a guiding concept for valuing diversity in knowledge development. Properties, risks, and resilience associated with the concept were detailed. This conceptualization of marginalization is reexamined here for its sociopolitical usefulness to nursing, from (1) critical theory, (2) postmodern, and (3) liberation philosophy perspectives. Additional properties are proposed to update the original conceptualization. These include: exteriority, Eurocentrism, constraint, economics, seduction, testimony, and hope. Effects of Eurocentric capitalism on all marginalized people are explored. Nursing implications include the need for interdisciplinary dialogue about the ethics of promoting and exporting Eurocentrism in nursing education and practice, and the need for integrated economic analyses of all aspects of life and health.

  17. SU-E-T-170: Characterization of the Location, Extent, and Proximity to Critical Structures of Target Volumes Provides Detail for Improved Outcome Predictions Among Pancreatic Cancer Patients

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Z; Moore, J; Rosati, L; Mian, O; Narang, A; Herman, J; McNutt, T [Johns Hopkins University, Baltimore, MD (United States)


    Purpose: In radiotherapy, size, location and proximity of the target to critical structures influence treatment decisions. It has been shown that proximity of the target predicts dosimetric sparing of critical structures. In addition to dosimetry, precise location of disease has further implications such as tumor invasion, or proximity to major arteries that inhibit surgery. Knowledge of which patients can be converted to surgical candidates by radiation may have high impact on future treat/no-treat decisions. We propose a method to improve our characterization of the location of pancreatic cancer and treatment volume extent with respect to nearby arteries with the goal of developing features to improve clinical predictions and decisions. Methods: Oncospace is a local learning health system that systematically captures clinical outcomes and all aspects of radiotherapy treatment plans, including overlap volume histograms (OVH) – a measure of spatial relationships between two structures. Minimum and maximum distances of PTV and OARs based on OVH, PTV volume, anatomic location by ICD-9 code, and surgical outcome were queried. Normalized distance to center from the left and right kidney was calculated to indicate tumor location and laterality. Distance to critical arteries (celiac, superior mesenteric, common hepatic) is validated by surgical status (borderline resectable, locally advanced converted to resectable). Results: There were 205 pancreas stereotactic body radiotherapy patients treated from 2009–2015 queried. Location/laterality of tumor based on kidney OVH show strong trends between location by OVH and by ICD-9. Compared to the locally advanced group, the borderline resectable group showed larger geometrical distance from critical arteries (p=0.03). Conclusion: Our platform enabled analysis of shape/size-location relationships. These data suggest that PTV volume and attention to distance between PTVs and surrounding OARs and major arteries may be

  18. Pathogenesis of splenic marginal zone lymphoma

    Directory of Open Access Journals (Sweden)

    Ming-Qing Du


    Full Text Available Splenic marginal zone lymphoma (SMZL is a distinct low grade B-cell lymphoma with an immunophenotype similar to that of splenic marginal zone B-cells. Like the normal splenic marginal zone B-cells, SMZLs also show variable features in somatic mutations of their rearranged immunoglobulin genes, with ∼90% of cases harbouring somatic mutations but at remarkably variable degrees, suggesting that SMZL may have multiple cell of origins, deriving from the heterogeneous B-cells of the splenic marginal zone. Notably, ∼30% of SMZLs show biased usage of IGHV1-2*04, with the expressed BCR being potentially polyreactive to autoantigens. Recent exome and targeted sequencing studies have identified a wide spectrum of somatic mutations in SMZL with the recurrent mutations targeting multiple signalling pathways that govern the development of splenic marginal zone B-cells. These recurrent mutations occur in KLF2 (20–42%, NOTCH2 (6.5–25%, NF-κB (CARD11 ∼7%, IKBKB ∼7%, TNFAIP3 7–13%, TRAF3 5%, BIRC3 6.3% and TLR (MYD88 5–13% signalling pathways. Interestingly, the majority of SMZL with KLF2 mutation have both 7q32 deletion and IGHV1-2 rearrangement, and these cases also have additional mutations in NOTCH2, or TNFAIP3, or TRAF3. There is a potential oncogenic cooperation among concurrent genetic changes, for example between the IGHV1-2 expressing BCR and KLF2 mutation in activation of the canonical NF-κB pathway, and between KLF2 and TRAF3 mutations in activation of the non-canonical NF-κB pathway. These novel genetic findings have provided considerable insights into the pathogenesis of SMZL and will stimulate the research in both normal and malignant marginal zone B-cells.

  19. The magmatic budget of Atlantic type rifted margins: is it related to inheritance? (United States)

    Manatschal, Gianreto; Tugend, Julia; Picazo, Suzanne; Müntener, Othmar


    In the past, Atlantic type rifted margins were either classified as volcanic or non-volcanic. An increasing number of high quality reflection and refraction seismic surveys and drill hole data show a divergent style of margin architecture and an evolution in which the quantity and distribution of syn-rift magmatism is variable, independently of the amount of extension. Overgeneralized classifications and models assuming simple relations between magmatic and extensional systems are thus inappropriate to describe the formation of rifted margins. More recent studies show that the magmatic evolution of rifted margins is complex and cannot be characterized based on the volume of observed magma alone. On the one hand, so-called "non-volcanic" margins are not necessarily amagmatic, as shown by the results of ODP drilling along the Iberia-Newfoundland rifted margins. On the other hand, magma-rich margins, such as the Norwegian, NW Australian or the Namibia rifted margins show evidence for hyper-extension prior to breakup. These observations suggest that the magmatic budget does not only depend on extension rates but also on the composition and temperature of the decompressing mantle. Moreover, the fact that the magmatic budget may change very abruptly along strike and across the margin is difficult to reconcile with the occurrence of plumes or other deep-seated large-scale mantle phenomena only. These overall observations result in questions on how magmatic and tectonic processes are interacting during rifting and lithospheric breakup and on how far inheritance may control the magmatic budget during rifting. In our presentation we will review results from the South and North Atlantic and the Alpine Tethys domain and will discuss the structural and magmatic evolution of so-called magma-rich and magma-poor rifted margins. In particular, we will try to define when, where and how much magma forms during rifting and lithospheric breakup. The key questions that we aim to address

  20. Working marginal reserves using Auger technology

    Energy Technology Data Exchange (ETDEWEB)

    Celada Tamames, B.


    Following up an idea put forward at a meeting of the PEN (National Energy Plan) R and D working party held in Ponferrada in the province of Leon, Ocicarbon contracted Geocontrol SA to carry out a study on the possible use of Auger technology for working marginal coal reserves. This article summarises the most important points in the final report on this project: current state of Auger technology, inventory of marginal coal reserves in Spain and the use of Auger technology in Spain. 6 figs., 2 tabs.

  1. Algorithms for computing the multivariable stability margin (United States)

    Tekawy, Jonathan A.; Safonov, Michael G.; Chiang, Richard Y.


    Stability margin for multiloop flight control systems has become a critical issue, especially in highly maneuverable aircraft designs where there are inherent strong cross-couplings between the various feedback control loops. To cope with this issue, we have developed computer algorithms based on non-differentiable optimization theory. These algorithms have been developed for computing the Multivariable Stability Margin (MSM). The MSM of a dynamical system is the size of the smallest structured perturbation in component dynamics that will destabilize the system. These algorithms have been coded and appear to be reliable. As illustrated by examples, they provide the basis for evaluating the robustness and performance of flight control systems.

  2. Jatropha potential on marginal land in Ethiopia

    DEFF Research Database (Denmark)

    Wendimu, Mengistu Assefa

    narrative. But both the availability and suitability of “marginal” land for commercial level jatropha production is not well understood/examined, especially in Africa. Using a case study of large-scale jatropha plantation in Ethiopia, this paper examines the process of land identification for jatropha...... investments, and the agronomic performance of large-scale jatropha plantation on so-called marginal land. Although it has been argued that jatropha can be grown well on marginal land without irrigation, and thus does not compete for land and water or displace food production from agricultural land, this study...

  3. Use of marginal organs in kidney transplantation for marginal recipients: too close to the margins of safety?

    Directory of Open Access Journals (Sweden)

    Heuer M


    Full Text Available Abstract Objective Due to organ shortage, average waiting time for a kidney in Germany is about 4 years after start of dialysis. Number of kidney grafts recovered can only be maintained by accepting older and expanded criteria donors. The aim of this study was to analyse the impact of donor and recipient risk on kidney long-term function. Methods All deceased kidney transplantations were considered. We retrospectively studied 332 patients between 2002 and 2006; divided in 4 groups reflecting donor and recipient risk. Results Non-marginal recipients were less likely to receive a marginal organ (69 of 207, 33% as compared to marginal recipients, of whom two-thirds received a marginal organ (p Conclusions As we were able to show expanded criteria donor has a far bigger effect on long-term graft function than the "extra risk" recipient. Although there have been attempts to define groups of recipients who should be offered ECD kidneys primarily the discussion is still ongoing.

  4. 17 CFR 242.405 - Withdrawal of margin. (United States)


    ...) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Customer Margin Requirements for Security Futures § 242.405 Withdrawal of margin. (a) By the customer. Except as otherwise... account after such withdrawal is sufficient to satisfy the required margin for the security futures...

  5. Complex patterns of faulting revealed by 3D seismic data at the West Galicia rifted margin (United States)

    Reston, Timothy; Cresswell, Derren; Sawyer, Dale; Ranero, Cesar; Shillington, Donna; Morgan, Julia; Lymer, Gael


    The west Galicia margin is characterised by crust thinning to less than 3 km, well-defined fault blocks, which overlie a bright reflection (the S reflector) generally interpreted as a tectonic Moho. The margin exhibits neither voluminous magmatism nor thick sediment piles to obscure the structures and the amount of extension. As such is represents an ideal location to study the process of continental breakup both through seismic imaging and potentially through drilling. Prestack depth migration of existing 2D profiles has strongly supported the interpretation of the S reflector as both a detachment and as the crust-mantle boundary; wide-angle seismic has also shown that the mantle beneath S is serpentinised. Despite the quality of the existing 2D seismic images, a number of competing models have been advanced to explain the formation of this margin, including sequential faulting, polyphase faulting, multiple detachments and the gravitational collapse of the margin over exhumed mantle. As these models, all developed for the Galicia margin, have been subsequently applied to other margins, distinguishing between them has implications not only for the structure of the Galicia margin but for the process of rifting through to breakup more generally. To address these issues in summer of 2013 we collected a 3D combined seismic reflection and wide-angle dataset over this margin. Here we present some of the results of ongoing processing of the 3D volume, focussing on the internal structure of some of the fault blocks that overlies the S detachment. 2D processing of the data shows a relatively simple series of tilted fault block, bound by west-dipping faults that detach downwards onto the bright S reflector. However, inspection of the 3D volume produced by 3D pre-stack time migration reveals that the fault blocks contain a complex set of sedimentary packages, with strata tilted to the east, west, north and south, each package bound by faults. Furthermore, the top of crustal

  6. Quantification and Assessment of Interfraction Setup Errors Based on Cone Beam CT and Determination of Safety Margins for Radiotherapy.

    Directory of Open Access Journals (Sweden)

    Macarena Cubillos Mesías

    Full Text Available To quantify interfraction patient setup-errors for radiotherapy based on cone-beam computed tomography and suggest safety margins accordingly.Positioning vectors of pre-treatment cone-beam computed tomography for different treatment sites were collected (n = 9504. For each patient group the total average and standard deviation were calculated and the overall mean, systematic and random errors as well as safety margins were determined.The systematic (and random errors in the superior-inferior, left-right and anterior-posterior directions were: for prostate, 2.5(3.0, 2.6(3.9 and 2.9(3.9mm; for prostate bed, 1.7(2.0, 2.2(3.6 and 2.6(3.1mm; for cervix, 2.8(3.4, 2.3(4.6 and 3.2(3.9mm; for rectum, 1.6(3.1, 2.1(2.9 and 2.5(3.8mm; for anal, 1.7(3.7, 2.1(5.1 and 2.5(4.8mm; for head and neck, 1.9(2.3, 1.4(2.0 and 1.7(2.2mm; for brain, 1.0(1.5, 1.1(1.4 and 1.0(1.1mm; and for mediastinum, 3.3(4.6, 2.6(3.7 and 3.5(4.0mm. The CTV-to-PTV margins had the smallest value for brain (3.6, 3.7 and 3.3mm and the largest for mediastinum (11.5, 9.1 and 11.6mm. For pelvic treatments the means (and standard deviations were 7.3 (1.6, 8.5 (0.8 and 9.6 (0.8mm.Systematic and random setup-errors were smaller than 5mm. The largest errors were found for organs with higher motion probability. The suggested safety margins were comparable to published values in previous but often smaller studies.

  7. Renormalized Volume (United States)

    Gover, A. Rod; Waldron, Andrew


    We develop a universal distributional calculus for regulated volumes of metrics that are suitably singular along hypersurfaces. When the hypersurface is a conformal infinity we give simple integrated distribution expressions for the divergences and anomaly of the regulated volume functional valid for any choice of regulator. For closed hypersurfaces or conformally compact geometries, methods from a previously developed boundary calculus for conformally compact manifolds can be applied to give explicit holographic formulæ for the divergences and anomaly expressed as hypersurface integrals over local quantities (the method also extends to non-closed hypersurfaces). The resulting anomaly does not depend on any particular choice of regulator, while the regulator dependence of the divergences is precisely captured by these formulæ. Conformal hypersurface invariants can be studied by demanding that the singular metric obey, smoothly and formally to a suitable order, a Yamabe type problem with boundary data along the conformal infinity. We prove that the volume anomaly for these singular Yamabe solutions is a conformally invariant integral of a local Q-curvature that generalizes the Branson Q-curvature by including data of the embedding. In each dimension this canonically defines a higher dimensional generalization of the Willmore energy/rigid string action. Recently, Graham proved that the first variation of the volume anomaly recovers the density obstructing smooth solutions to this singular Yamabe problem; we give a new proof of this result employing our boundary calculus. Physical applications of our results include studies of quantum corrections to entanglement entropies.

  8. Geological features and geophysical signatures of continental margins of India

    Digital Repository Service at National Institute of Oceanography (India)

    Krishna, K.S.

    and classification of continental margins are in general dependent on style of continental splitting, rifting, subsidence and their proximity to the tectonic plate boundaries, at times the margins undergo for modifications by sediment deposition and volcanic... by Deccan-Reunion hotspot volcanism and Bengal Fan sedimentation respectively. Volcanism has dominated on the western continental margin of India, thereby the margin had been turned into a volcanic passive continental margin, while eastern continental...

  9. A sea ice model for the marginal ice zone with an application to the Greenland Sea

    DEFF Research Database (Denmark)

    Pedersen, Leif Toudal; Coon, Max D.


    A model is presented that describes the formation, transport, and desalinization of frazil and pancake ice as it is formed in marginal seas. This model uses as input the total ice concentration evaluated from Special Sensor Microwave Imager and wind speed and direction. The model calculates...... the areal concentration, thickness, volume concentration, and salinity of frazil ice as well as the areal concentration, thickness, and salinity of pancakes. A simple parameterization for the Odden region of the Greenland Sea is presented. The model is run for the winter of 1996-1997. There are direct...... observations of the thickness and salinity of pancakes and the volume concentration of frazil ice to compare with the model. The model results compare very well with the measured data. This new ice model can be tuned to work in marginal seas elsewhere to calculate ice thickness, motion, and brine rejection...

  10. Deriving margins in prostate cancer radiotherapy treatment: comparison of neural network and fuzzy logic models. (United States)

    Mzenda, Bongile; Gegov, Alexander; Brown, David J; Petrov, Nedyalko


    This study investigates the feasibility of using Artificial Neural Network (ANN) and fuzzy logic based techniques to select treatment margins for dynamically moving targets in the radiotherapy treatment of prostate cancer. The use of data from 15 patients relating error effects to the Tumour Control Probability (TCP) and Normal Tissue Complication Probability (NTCP) radiobiological indices was contrasted against the use of data based on the prostate volume receiving 99% of the prescribed dose (V99%) and the rectum volume receiving more than 60Gy (V60). For the same input data, the results of the ANN were compared to results obtained using a fuzzy system, a fuzzy network and current clinically used statistical techniques. Compared to fuzzy and statistical methods, the ANN derived margins were found to be up to 2 mm larger at small and high input errors and up to 3.5 mm larger at medium input error magnitudes.

  11. Great earthquakes along the Western United States continental margin: implications for hazards, stratigraphy and turbidite lithology

    Directory of Open Access Journals (Sweden)

    C. H. Nelson


    Full Text Available We summarize the importance of great earthquakes (Mw ≳ 8 for hazards, stratigraphy of basin floors, and turbidite lithology along the active tectonic continental margins of the Cascadia subduction zone and the northern San Andreas Transform Fault by utilizing studies of swath bathymetry visual core descriptions, grain size analysis, X-ray radiographs and physical properties. Recurrence times of Holocene turbidites as proxies for earthquakes on the Cascadia and northern California margins are analyzed using two methods: (1 radiometric dating (14C method, and (2 relative dating, using hemipelagic sediment thickness and sedimentation rates (H method. The H method provides (1 the best estimate of minimum recurrence times, which are the most important for seismic hazards risk analysis, and (2 the most complete dataset of recurrence times, which shows a normal distribution pattern for paleoseismic turbidite frequencies. We observe that, on these tectonically active continental margins, during the sea-level highstand of Holocene time, triggering of turbidity currents is controlled dominantly by earthquakes, and paleoseismic turbidites have an average recurrence time of ~550 yr in northern Cascadia Basin and ~200 yr along northern California margin. The minimum recurrence times for great earthquakes are approximately 300 yr for the Cascadia subduction zone and 130 yr for the northern San Andreas Fault, which indicates both fault systems are in (Cascadia or very close (San Andreas to the early window for another great earthquake.

    On active tectonic margins with great earthquakes, the volumes of mass transport deposits (MTDs are limited on basin floors along the margins. The maximum run-out distances of MTD sheets across abyssal-basin floors along active margins are an order of magnitude less (~100 km than on passive margins (~1000 km. The great earthquakes along the Cascadia and northern California margins


    Energy Technology Data Exchange (ETDEWEB)



    BI-OMP supports DOE's mission in Climate Change Research. The program provides the fundamental understanding of the linkages between carbon and nitrogen cycles in ocean margins. Researchers are providing a mechanistic understanding of these cycles, using the tools of modern molecular biology. The models that will allow policy makers to determine safe levels of greenhouse gases for the Earth System.

  13. Recidiva tardia de linfoma da zona marginal


    Rocha,Talita M. B.S.; Bortolheiro,Tereza C.; Costa, Eduardo; Haardt,Daniela; Roberto P. Paes; Chiattone, Carlos S.


    O linfoma de zona marginal é um linfoma de baixo grau com curso clínico indolente e potencial de recidiva.1,2 Apresentamos um caso de recidiva tardia após 25 anos de aparente remissão completa, levantando a possibilidade de recidiva de doença preexistente ou desenvolvimento de novo clone neoplásico.

  14. Large margin image set representation and classification

    KAUST Repository

    Wang, Jim Jing-Yan


    In this paper, we propose a novel image set representation and classification method by maximizing the margin of image sets. The margin of an image set is defined as the difference of the distance to its nearest image set from different classes and the distance to its nearest image set of the same class. By modeling the image sets by using both their image samples and their affine hull models, and maximizing the margins of the images sets, the image set representation parameter learning problem is formulated as an minimization problem, which is further optimized by an expectation - maximization (EM) strategy with accelerated proximal gradient (APG) optimization in an iterative algorithm. To classify a given test image set, we assign it to the class which could provide the largest margin. Experiments on two applications of video-sequence-based face recognition demonstrate that the proposed method significantly outperforms state-of-the-art image set classification methods in terms of both effectiveness and efficiency.

  15. New perceptions of continrntal margin biodiversity

    Digital Repository Service at National Institute of Oceanography (India)

    Menot, L.; Sibuet, M.; Carney, R.S.; Levin, L.A.; Rowe, G.T.; Billett, D.S.M.; Poore, G.; Kitazato, H.; Vanreusel, A.; Galeron, J.; Lavrado, H.P.; Sellanes, J.; Ingole, B.S.; Krylova, E.

    margins to major marine laboratories in developed countries. Such studies shaped our original, sometimes naïve, conceptions of what lives on these steep depth gradients even though we perceived the deep environment from afar and at a poor resolution...

  16. Sustainable biomass production on Marginal Lands (SEEMLA) (United States)

    Barbera, Federica; Baumgarten, Wibke; Pelikan, Vincent


    Sustainable biomass production on Marginal Lands (SEEMLA) The main objective of the H2020 funded EU project SEEMLA (acronym for Sustainable Exploitation of Biomass for Bioenergy from Marginal Lands in Europe) is the establishment of suitable innovative land-use strategies for a sustainable production of plant-based energy on marginal lands while improving general ecosystem services. The use of marginal lands (MagL) could contribute to the mitigation of the fast growing competition between traditional food production and production of renewable bio-resources on arable lands. SEEMLA focuses on the promotion of re-conversion of MagLs for the production of bioenergy through the direct involvement of farmers and forester, the strengthening of local small-scale supply chains, and the promotion of plantations of bioenergy plants on MagLs. Life cycle assessment is performed in order to analyse possible impacts on the environment. A soil quality rating tool is applied to define and classify MagL. Suitable perennial and woody bioenergy crops are selected to be grown in pilot areas in the partner countries Ukraine, Greece and Germany. SEEMLA is expected to contribute to an increasing demand of biomass for bioenergy production in order to meet the 2020 targets and beyond.

  17. Female Special Education Directors: Doubly Marginalized. (United States)

    Keefe, Charlotte Hendrick; Parmley, Pamela


    A qualitative study of five Texas female special education directors found that although participants achieved an administrative position, they were marginalized due to their leadership style, gender discrimination, and socialization. Participants also indicated a negative connection between being in special education administration and top-level…

  18. The marginal cost of public funds

    DEFF Research Database (Denmark)

    Kleven, Henrik Jacobsen; Kreiner, Claus Thustrup


    This paper extends the theory and measurement of the marginal cost of public funds (MCF) to account for labor force participation responses. Our work is motivated by the emerging consensus in the empirical literature that extensive (participation) responses are more important than intensive (hours...


    Energy Technology Data Exchange (ETDEWEB)

    Nam Dinh; Ronaldo Szilard


    The concept of safety margins has served as a fundamental principle in the design and operation of commercial nuclear power plants (NPPs). Defined as the minimum distance between a system’s “loading” and its “capacity”, plant design and operation is predicated on ensuring an adequate safety margin for safety-significant parameters (e.g., fuel cladding temperature, containment pressure, etc.) is provided over the spectrum of anticipated plant operating, transient and accident conditions. To meet the anticipated challenges associated with extending the operational lifetimes of the current fleet of operating NPPs, the United States Department of Energy (USDOE), the Idaho National Laboratory (INL) and the Electric Power Research Institute (EPRI) have developed a collaboration to conduct coordinated research to identify and address the technological challenges and opportunities that likely would affect the safe and economic operation of the existing NPP fleet over the postulated long-term time horizons. In this paper we describe a framework for developing and implementing a Risk-Informed Safety Margin Characterization (RISMC) approach to evaluate and manage changes in plant safety margins over long time horizons.

  20. Marginal Strength of Collarless Metal Ceramic Crown

    Directory of Open Access Journals (Sweden)

    Sikka Swati


    fracture strength at margins of metal ceramic crowns cemented to metal tooth analogs. Crowns evaluated with different marginal configurations, shoulder and shoulder bevel with 0 mm, 0.5 mm, 1 mm, and 1.5 mm, were selected. Methods. Maxillary right canine typhodont tooth was prepared to receive a metal ceramic crown with shoulder margin. This was duplicated to get 20 metal teeth analogs. Then the same tooth was reprepared to get shoulder bevel configuration. These crowns were then cemented onmetal teeth analogs and tested for fracture strength atmargin on an Instron testing machine. A progressive compressive load was applied using 6.3 mm diameter rod with crosshead speed of 2.5 mm per minute. Statisticaly analysis was performed with ANOVA, Student's “t” test and “f” test. Results. The fracture strength of collarless metal ceramic crowns under study exceeded the normal biting force. Therefore it can be suggested that collarless metal ceramic crowns with shoulder or shoulder bevel margins up to 1.5 mm framework reduction may be indicated for anteriormetal ceramic restorations. Significance. k Collarless metal ceramic crowns have proved to be successful for anterior fixed restorations. Hence, it may be subjected to more clinical trials.

  1. Negative Stress Margins - Are They Real? (United States)

    Raju, Ivatury S.; Lee, Darlene S.; Mohaghegh, Michael


    Advances in modeling and simulation, new finite element software, modeling engines and powerful computers are providing opportunities to interrogate designs in a very different manner and in a more detailed approach than ever before. Margins of safety are also often evaluated using local stresses for various design concepts and design parameters quickly once analysis models are defined and developed. This paper suggests that not all the negative margins of safety evaluated are real. The structural areas where negative margins are frequently encountered are often near stress concentrations, point loads and load discontinuities, near locations of stress singularities, in areas having large gradients but with insufficient mesh density, in areas with modeling issues and modeling errors, and in areas with connections and interfaces, in two-dimensional (2D) and three-dimensional (3D) transitions, bolts and bolt modeling, and boundary conditions. Now, more than ever, structural analysts need to examine and interrogate their analysis results and perform basic sanity checks to determine if these negative margins are real.

  2. Mundhulens mikroflora hos patienter med marginal parodontitis

    DEFF Research Database (Denmark)

    Larsen, Tove; Fiehn, Nils-Erik


    Viden om marginal parodontitis’ mikrobiologi tog for alvor fart for ca. 40 år siden. Den tidlige viden var baseret på mikroskopiske og dyrkningsmæssige undersøgelser af den subgingivale plak. Anvendelsen af de nyere molekylærbiologiske metoder har betydet, at vor viden om de ætiologiske faktorer...

  3. Processes of marginalization in relation to participation

    DEFF Research Database (Denmark)

    Lagermann, Laila Colding


    This paper discusses processes of marginalization in relation to the participation of two students, Amir and Saad, in the school in Copenhagen, Denmark, which they attend but also across the school and different communities outside the school. In the paper I discuss the effect of some teachers...

  4. An information criterion for marginal structural models. (United States)

    Platt, Robert W; Brookhart, M Alan; Cole, Stephen R; Westreich, Daniel; Schisterman, Enrique F


    Marginal structural models were developed as a semiparametric alternative to the G-computation formula to estimate causal effects of exposures. In practice, these models are often specified using parametric regression models. As such, the usual conventions regarding regression model specification apply. This paper outlines strategies for marginal structural model specification and considerations for the functional form of the exposure metric in the final structural model. We propose a quasi-likelihood information criterion adapted from use in generalized estimating equations. We evaluate the properties of our proposed information criterion using a limited simulation study. We illustrate our approach using two empirical examples. In the first example, we use data from a randomized breastfeeding promotion trial to estimate the effect of breastfeeding duration on infant weight at 1 year. In the second example, we use data from two prospective cohorts studies to estimate the effect of highly active antiretroviral therapy on CD4 count in an observational cohort of HIV-infected men and women. The marginal structural model specified should reflect the scientific question being addressed but can also assist in exploration of other plausible and closely related questions. In marginal structural models, as in any regression setting, correct inference depends on correct model specification. Our proposed information criterion provides a formal method for comparing model fit for different specifications.

  5. Marginal adaptation of ceramic inserts after cementation

    NARCIS (Netherlands)

    Ozcan, M; Pfeiffer, P; Nergiz, [No Value


    The advantage of using ceramic inserts is to prevent major drawbacks of composite resins such as polymerization shrinkage, wear and microleakage. This in vitro study evaluated the marginal adaptation of two approximal ceramic insert systems after cementation to the cavities opened with ultrasonic ti

  6. The marginal costs of climate changing emissions

    NARCIS (Netherlands)

    Tol, R.S.J.; Downing, T.E.


    This paper presents the marginal costs of the emissions of a selected number of radiatively-active gases, three uniformly-mixed gases – carbon dioxide, methane, nitrous oxide – and two region-specific gases – nitrogen (from aircraft) and sulphur, which influence ozone and sulphate aerosol concentrat

  7. On the concept and process of marginalization

    NARCIS (Netherlands)

    J.B.W. Kuitenbrouwer (Joost)


    textabstractThe concept of marginalization has its genesis in the processes of transformation which have characterized the societies of Latin America (CEPAL). It is increasingly being used to denote similar processes in other parts of the world through which groups of the population are relegated to

  8. Early math intervention for marginalized students

    DEFF Research Database (Denmark)

    Overgaard, Steffen; Tonnesen, Pia Beck


    This study is one of more substudies in the project Early Math Intervention for Marginalized Students (TMTM2014). The paper presents the initial process of this substudy that will be carried out fall 2015. In the TMTM2014 project, 80 teachers, who completed a one week course in the idea of TMTM...

  9. Structural Marginality and the Urban Social Order. (United States)

    Kapferer, Bruce


    This article argues for a redefinition of "Marginality" in terms of the principles that influence the developing order of the urban formation as a whole. The emerging social order and the political participation of residents of two shanty areas in Kabwe, Zambia are traced over a period of 40 years. (Author/EB)

  10. The pre-Caledonian margin of Baltica (United States)

    Andersen, Torgeir B.; Jørgen Kjøll, Hans; Jakob, Johannes; Corfu, Fernando; Tegner, Christian


    It is well-documented that the pre-Caledonian margin of Baltica constituted a several hundred-km wide and more than 2000 km long passive margin. Its vestiges occur at low- to intermediate structural levels in the mountain belt, and are variably overprinted by the early- to end-Caledonian orogenic deformation and extension. Attempts to reconstruct the Caledonian margin of Baltica must be based on detailed maps integrated with studies of the rock-complexes that originally constituted the passive margin. The proximal parts of pre-Caledonian margin of Baltica are dominated by continental rift basins with coarse to fine-grained sediments deposited in the late Proterozoic through the Ediacaran and into the Lower Palaeozoic. The youngest dated clastic zircons probably record magmatism associated with initial contraction near or in the distal margin. The 'margin nappes' also comprise Baltican basement slivers and coarse to fine-grained sedimentary units as well as deep-marine basin deposits. A major change in the architecture of the passive margin units takes place across a transvers zone, which is sub-parallel to the present-day Gudbrandsdalen of South Norway. The transition is roughly parallel to the major basement lineament of the Sveconorwegian orogenic front in south Norway. The most important change across this transverse lineament is that the NE segment is magma-rich, characterized by abundant basaltic magmatism. The SW segment is magma-poor, and characterised by numerous (>100) solitary meta-peridotites, mostly meta-dunites and meta-harzburgites as well as a number of detrital serpentinites and soapstones. These are interpreted as fragments of exhumed mantle and their erosion products, respectively. The meta-peridotites emplaced structurally, and covered by dominantly deep-basin sediments, but also by coarser sedimentary breccias and conglomerates, as part of the rifted margin development. This mixed unit (mélange) was locally intruded by Late Cambrian to Early

  11. The Seismicity of Two Hyperextended Margins (United States)

    Redfield, Tim; Terje Osmundsen, Per


    A seismic belt marks the outermost edge of Scandinavia's proximal margin, inboard of and roughly parallel to the Taper Break. A similar near- to onshore seismic belt runs along its inner edge, roughly parallel to and outboard of the asymmetric, seaward-facing escarpment. The belts converge at both the northern and southern ends of Scandinavia, where crustal taper is sharp and the proximal margin is narrow. Very few seismic events have been recorded on the intervening, gently-tapering Trøndelag Platform. Norway's distribution of seismicity is systematically ordered with respect to 1) the structural templates of high-beta extension that shaped the thinning gradient during Late Jurassic or Early Cretaceous time, and 2) the topographically resurgent Cretaceous-Cenozoic "accommodation phase" family of escarpments that approximate the innermost limit of crustal thinning [See Redfield and Osmundsen (2012) for diagrams, definitions, discussion, and supporting citations.] Landwards from the belt of earthquake epicenters that mark the Taper Break the crust consistently thickens, and large fault arrays tend to sole out at mid crustal levels. Towards the sea the crystalline continental crust is hyperextended, pervasively faulted, and generally very thin. Also, faulting and serpentinization may have affected the uppermost parts of the distal margin's lithospheric mantle. Such contrasting structural conditions may generate a contrasting stiffness: for a given stress, more strain can be accommodated in the distal margin than in the less faulted proximal margin. By way of comparison, inboard of the Taper Break on the gently-tapered Trøndelag Platform, faulting was not penetrative. There, similar structural conditions prevail and proximal margin seismicity is negligible. Because stress concentration can occur where material properties undergo significant contrast, the necking zone may constitute a natural localization point for post-thinning phase earthquakes. In Scandinavia

  12. Leukocyte margination in a model microvessel (United States)

    Freund, Jonathan B.


    The physiological inflammation response depends upon the multibody interactions of blood cells in the microcirculation that bring leukocytes (white blood cells) to the vessel walls. We investigate the fluid mechanics of this using numerical simulations of 29 red blood cells and one leukocyte flowing in a two-dimensional microvessel, with the cells modeled as linearly elastic shell membranes. Despite its obvious simplifications, this model successfully reproduces the increasingly blunted velocity profiles and increased leukocyte margination observed at lower shear rates in actual microvessels. Red cell aggregation is shown to be unnecessary for margination. The relative stiffness of the red cells in our simulations is varied by over a factor of 10, but the margination is found to be much less correlated with this than it is to changes associated with the blunting of the mean velocity profile at lower shear rates. While velocity around the leukocyte when it is near the wall depends upon the red cell properties, it changes little for strongly versus weakly marginating cases. In the more strongly marginating cases, however, a red cell is frequently observed to be leaning on the upstream side of the leukocyte and appears to stabilize it, preventing other red cells from coming between it and the wall. A well-known feature of the microcirculation is a near-wall cell-free layer. In our simulations, it is observed that the leukocyte's most probable position is at the edge of this layer. This wall stand-off distance increases with velocity following a scaling that would be expected for a lubrication mechanism, assuming that there were a nearly constant force pushing the cells toward the wall. The leukocyte's near-wall position is observed to be less stable with increasing mean stand-off distance, but this distance would have potentially greater effect on adhesion since the range of the molecular binding is so short.

  13. Financial Intermediation, Monetary Uncertainty, and Bank Interest Margins Financial Intermediation, Monetary Uncertainty, and Bank Interest Margins

    Directory of Open Access Journals (Sweden)

    Leonardo Hernández


    Full Text Available Financial Intermediation, Monetary Uncertainty, and Bank Interest Margins This paper studies a simple model of financial intermediation in order to understand how the lending-borrowing spread or interest margin charged by financial intermediaries is determined in equilibrium in a monetary economy. The main conclusion of the paper concerns the effect on the spread of changes in the distribution of monetary innovations. Thus, changes in the monetary-policy-rule followed by the Central Bank which alter the volatility of inflation will have important effects on the interest margin and also on the amount of credit available to investors. A crosssection empirical analysis strongly supports our hypothesis:

  14. Deep crustal structure and continent-ocean boundary along the Galicia continental margin (NW Iberia) (United States)

    Druet, María; Muñoz-Martín, Alfonso; Carbó, Andrés; Acosta, Juan; Granja Bruña, José Luis; Llanes, Pilar; Vázquez, Juan-Tomás; Ercilla, Gemma


    The Galicia continental margin is a magma-poor rifted margin with an extremely complex structure. Its formation involves several rifting episodes during the Mesozoic in the vicinity of a ridge triple junction, which produces a change in the orientation of the main structures. In addition, there is an overimposed Cenozoic partial tectonic inversion along its northern border. Although this continental margin has been widely studied since the 70's, most studies have focused on its western part in the transition to the Iberia Abyssal Plain, and there is a significant lack of information on the north and northwestern flanks of this margin. This fact, along with its great structural complexity, has resulted in the absence of a previous comprehensive regional geodynamic model integrating all the processes observed. In the present study we integrate a large volume of new geophysical data (gravity, swath bathymetry and 2D multichannel reflection seismic). Data come from the systematic mapping of the Spanish EEZ project which provides a dense grid of gravity data and full seafloor coverage with swath bathymetry, and from the ERGAP project which provides serially-arranged 2D seismic reflection profiles across the NW Iberia margin. The combined interpretation and modelling of this new information has arisen significant constraints on the origin, the deep crustal structure and the physiographic complexity of the margin, as well as on the characterization of the along- and across-strike variation of the ocean-continent transition along NW Iberia margin. The analysis of this information leads us to propose a conceptual model for the initiation of the tectonic inversion of a magma-poor rifted margin. Finally, a framework for the geodynamic evolution of the Galicia margin has been constructed, involving three main stages: A) an early stage from the end of rifting and oceanic drift in the Bay of Biscay (Santonian); B) an intermediate stage with the beginning of tectonic inversion in

  15. 肝癌术后简化调强放疗临床靶体积误差的锥形束CT分析%Analysis of clinical target volume positioning errors using cone beam computed tomography for patients with liver tumors with postoperative simplefied intensity-modulated radiotherapy

    Institute of Scientific and Technical Information of China (English)

    张涛; 王维虎; 金晶; 王淑莲; 宋永文; 刘跃平; 戴建荣; 李晔雄


    -posterior (z) axis were calculated in 111 groups,and intra-fractional translational CTV positioning errors in 70 groups.Clinical to planning target volume (PTV) margins were calculated according to the formula:margin =2.0 ∑ + 0.7σ ( ∑ is systematic error,σ is random error).Results Inter-fractional translational CTV positioning errors in x,y and z axis were -0.03 mm,-0.43 mm,1.02 mm,with systematic error ( ∑ ) of 1.50 mm,5.89 mm,1.97 mm,and random error (σ) of 1.76 mm,4.13 mm,2.42 mm,respectively.Intra-fractional translational CTV positioning errors in the x,y,z axis were 0.04 mm,0.86 mm,- 0.46mm,with systematic error (∑) of 0.46 mm,1.14 mm,0.31 mm,and random error (σ) of 0.95 mm,1.38 mm,0.91 mm,respectively.The calculate CTV to PTV margins were 4.5 mm,15.0 mm,5.8 mm in the x,y,z axis,respectively.Conclusions The CTV errors were inevitable when patients with liver tumors received SIMRT.Fiducial markers placed in tumor bed during operation were helpful for accurate positioning error analysis.

  16. Adaptive Marginal Median Filter for Colour Images

    Directory of Open Access Journals (Sweden)

    Almanzor Sapena


    Full Text Available This paper describes a new filter for impulse noise reduction in colour images which is aimed at improving the noise reduction capability of the classical vector median filter. The filter is inspired by the application of a vector marginal median filtering process over a selected group of pixels in each filtering window. This selection, which is based on the vector median, along with the application of the marginal median operation constitutes an adaptive process that leads to a more robust filter design. Also, the proposed method is able to process colour images without introducing colour artifacts. Experimental results show that the images filtered with the proposed method contain less noisy pixels than those obtained through the vector median filter.

  17. Distributions with given marginals and statistical modelling

    CERN Document Server

    Fortiana, Josep; Rodriguez-Lallena, José


    This book contains a selection of the papers presented at the meeting `Distributions with given marginals and statistical modelling', held in Barcelona (Spain), July 17-20, 2000. In 24 chapters, this book covers topics such as the theory of copulas and quasi-copulas, the theory and compatibility of distributions, models for survival distributions and other well-known distributions, time series, categorical models, definition and estimation of measures of dependence, monotonicity and stochastic ordering, shape and separability of distributions, hidden truncation models, diagonal families, orthogonal expansions, tests of independence, and goodness of fit assessment. These topics share the use and properties of distributions with given marginals, this being the fourth specialised text on this theme. The innovative aspect of the book is the inclusion of statistical aspects such as modelling, Bayesian statistics, estimation, and tests.

  18. Time Domain Stability Margin Assessment Method (United States)

    Clements, Keith


    The baseline stability margins for NASA's Space Launch System (SLS) launch vehicle were generated via the classical approach of linearizing the system equations of motion and determining the gain and phase margins from the resulting frequency domain model. To improve the fidelity of the classical methods, the linear frequency domain approach can be extended by replacing static, memoryless nonlinearities with describing functions. This technique, however, does not address the time varying nature of the dynamics of a launch vehicle in flight. An alternative technique for the evaluation of the stability of the nonlinear launch vehicle dynamics along its trajectory is to incrementally adjust the gain and/or time delay in the time domain simulation until the system exhibits unstable behavior. This technique has the added benefit of providing a direct comparison between the time domain and frequency domain tools in support of simulation validation.

  19. Rigidity of marginally outer trapped 2-spheres

    CERN Document Server

    Galloway, Gregory J


    In a matter-filled spacetime, perhaps with positive cosmological constant, a stable marginally outer trapped 2-sphere must satisfy a certain area inequality. Namely, as discussed in the paper, its area must be bounded above by $4\\pi/c$, where $c > 0$ is a lower bound on a natural energy-momentum term. We then consider the rigidity that results for stable, or weakly outermost, marginally outer trapped 2-spheres that achieve this upper bound on the area. In particular, we prove a splitting result for 3-dimensional initial data sets analogous to a result of Bray, Brendle and Neves [10] concerning area minimizing 2-spheres in Riemannian 3-manifolds with positive scalar curvature. We further show that these initial data sets locally embed as spacelike hypersurfaces into the Nariai spacetime. Connections to the Vaidya spacetime and dynamical horizons are also discussed.

  20. Passive target tracking using marginalized particle filter

    Institute of Scientific and Technical Information of China (English)


    A marginalized particle filtering(MPF)approach is proposed for target tracking under the background of passive measurement.Essentially,the MPF is a combination of particle filtering technique and Kalman filter.By making full use of marginalization,the distributions of the tractable linear part of the total state variables are updated analytically using Kalman filter,and only the lower-dimensional nonlinear state variable needs to be dealt with using particle filter.Simulation studies are performed on an illustrative example,and the results show that the MPF method leads to a significant reduction of the tracking errors when compared with the direct particle implementation.Real data test results also validate the effectiveness of the presented method.

  1. Marginal Loss Calculations for the DCOPF

    Energy Technology Data Exchange (ETDEWEB)

    Eldridge, Brent [Federal Energy Regulatory Commission, Washington, DC (United States); Johns Hopkins Univ., Baltimore, MD (United States); O' Neill, Richard P. [Federal Energy Regulatory Commission, Washington, DC (United States); Castillo, Andrea R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)


    The purpose of this paper is to explain some aspects of including a marginal line loss approximation in the DCOPF. The DCOPF optimizes electric generator dispatch using simplified power flow physics. Since the standard assumptions in the DCOPF include a lossless network, a number of modifications have to be added to the model. Calculating marginal losses allows the DCOPF to optimize the location of power generation, so that generators that are closer to demand centers are relatively cheaper than remote generation. The problem formulations discussed in this paper will simplify many aspects of practical electric dispatch implementations in use today, but will include sufficient detail to demonstrate a few points with regard to the handling of losses.

  2. European refiners re-adjust margins strategy

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, R.G. [ed.


    Refiners in Europe are adjusting operating strategies to reflect the volatilities of tight operating margins. From the unexpected availability of quality crudes (e.g., Brent, 0.3% sulfur), to the role of government in refinery planning, the European refining industry is positioning itself to reverse the past few years of steadily declining profitability. Unlike expected increases in US gasoline demand, European gasoline consumption is not expected to increase, and heavy fuel oil consumption is also declining. However, diesel fuel consumption is expected to increase, even though diesel processing capacity has recently decreased (i.e., more imports). Some of the possible strategies that Europeans may adapt to improve margins and reduce volatility include: Increase conversion capacity to supply growing demand for middle distillates and LPG; alleviate refinery cash flow problems with alliances; and direct discretionary investment toward retail merchandising (unless there is a clear trend toward a widening of the sweet-sour crude price differential).

  3. Marginal longitudinal semiparametric regression via penalized splines

    KAUST Repository

    Al Kadiri, M.


    We study the marginal longitudinal nonparametric regression problem and some of its semiparametric extensions. We point out that, while several elaborate proposals for efficient estimation have been proposed, a relative simple and straightforward one, based on penalized splines, has not. After describing our approach, we then explain how Gibbs sampling and the BUGS software can be used to achieve quick and effective implementation. Illustrations are provided for nonparametric regression and additive models.

  4. Negative marginal tax rates and heterogeneity


    Choné, Philippe; Laroque, Guy


    Heterogeneity is likely to be an important determinant of the shape of optimal tax schemes. This article addresses the issue in a model à la Mirrlees with a continuum of agents. The agents differ in their productivities and opportunity costs of work, but their labor supplies depend only on a unidimensional combination of their two characteristics. Conditions are given under which the standard result that marginal tax rates are everywhere non-negative holds. This is in particular the case when...

  5. Mining their own Business in the Margins

    DEFF Research Database (Denmark)

    Jensen, Lars

    Mining has long been established in Australian public discourse as an activity that has driven the Australian economy, and guaranteed Australia against the economic ills of the rest of the West. Or put slightly differently, the positive spin on mining in public discourse and the financial market,...... of speaking about margins/marginalisation in relation to the mining industry, that is, as something conducted beyond the horizon, something which defines the horizon - and as a process through which remoteness defines the (national) self....

  6. Authigenic minerals from the continental margins

    Digital Repository Service at National Institute of Oceanography (India)

    Rao, V.P.

    phosphorites have been presumed to be sedimented plankton organic matter, fish debris, and iron-redox phosphate pump. Several workers investigated the genesis of sedimentary phosphorites occurring from Precambrian to Recent and proposed different...-phosphate sediments of the western continental margin of India showed that phosphate occurred as apatite microparticles that resembled fossilized phosphate bacteria and/or microbial filaments (Fig. 3). This established the prominence of micro- environments...


    Directory of Open Access Journals (Sweden)

    Ratnawati Tahir


    Full Text Available Abstract: Alternative Education for Marginalized Women in Rural Areas. The study aims to find alter­native forms of education for marginalized women, the process of forming study groups and gender based learning process that serves the center of the development of education, leadership and a source of economic empowerment. The study uses qualitative methods, involving a group of women who have attended an al­ternative education. Researchers and informants from community leaders. The results showed that the form of alternative education is a method of adult education or andragogy. Study groups consisted of basic literacy and functional literacy. The learning process begins with the sharing of learning, reflection on life experience and role play method. The result is 65% of participants have increased the ability of reading, writing and numeracy, and understanding of the issues of women who have confidence in the decision making of households and communities. Abstrak: Pendidikan Alternatif untuk Perempuan Marginal di Pedesaan. Penelitian ini bertujuan mengetahui bentuk pendidikan alternatif untuk perempuan marginal, proses pembentukan kelompok belajar, dan proses pembelajaran berperspektif gender yang berfungsi menjadi pusat pengembangan pendidikan, kepemimpinan, dan sumber penguatan ekonomi. Penelitian menggunakan metode kualitatif, mengambil satu kelompok perempuan yang telah mengikuti pendidikan alternatif. Informan terdiri atas tokoh masyarakat, seperti Kepala Desa, Ketua RT/RW, dan ibu rumah tangga. Hasil penelitian menunjukkan bahwa bentuk pembelajaran pendidikan alternatif adalah metode pendidikan orang dewasa atau andragogy. Pembentukan kelompok belajar terdiri atas; kelompok baca tulis dan keaksaraan fungsional. Proses pembe­lajaran dimulai dengan sharing pembelajaran, refleksi pengalaman hidup, dan metode role play. Hasilnya 65% peserta pembelajaran mengalami peningkatan kemampuan membaca, menulis, dan berhitung, serta pema

  8. Statistical Mechanics of Soft Margin Classifiers


    Risau-Gusman, Sebastian; Gordon, Mirta B.


    We study the typical learning properties of the recently introduced Soft Margin Classifiers (SMCs), learning realizable and unrealizable tasks, with the tools of Statistical Mechanics. We derive analytically the behaviour of the learning curves in the regime of very large training sets. We obtain exponential and power laws for the decay of the generalization error towards the asymptotic value, depending on the task and on general characteristics of the distribution of stabilities of the patte...

  9. Marginal Ice Zone: Biogeochemical Sampling with Gliders (United States)


    ocean and base of marine food webs, are responding to changing conditions in the Arctic Ocean . The high-level project goals are to use underwater...observing array (Fig. 1). The glider sensor suite included temperature , temperature microstructure, salinity , oxygen, chlorophyll fluorescence, optical...presented at the Arctic Science Summit Week in Toyama, Japan, in April 2015 (Direct Observations of Ocean Variability Across the Arctic Marginal Ice Zone

  10. Marginal microfiltration in amalgam restorations. Review


    Lahoud Salem, Víctor; Departamento Académico de Estomatología Rehabilitadora. Facultad de Odontología, Universidad Nacional Mayor de San Marcos, Lima. Perú.


    The present articule is review references from phenomenon of microfiltration in restorations with amalgam and yours consecuents in changes of color in the interface tooth-restorations, margin deterioted , sensitivity dentinarea postoperate, caries secondary and pulp inflamation. Besides naming the mechanicals for to reduce microfiltration, and yours effects for use of sealers dentinaries representation for the varnish cavitys and adhesive systens Conclusive indicate wath the amalgam is the ma...

  11. Marginal selenium status in northern Tasmania. (United States)

    Beckett, Jeffrey M; Ball, Madeleine J


    Se plays many important roles in humans. Marginal Se status has been associated with adverse health effects including an increased risk of chronic disease such as cancer. There are few Australian data, but the population of Tasmania, Australia, is potentially at risk of marginal Se status. A cross-sectional study of 498 men and women aged 25-84 years was undertaken to assess the Se status of the northern Tasmanian population. Se status was assessed using dietary estimates and measures of serum Se and glutathione peroxidase (GPx). Mean Se intakes were 77·4 (sd 31·3) and 65·1 (sd 23·7) μg/d for men and women, respectively; 27 % of the subjects consumed less than the Australian/New Zealand estimated average requirement. Mean serum Se concentration was 89·1 (sd 15·1) μg/l; 83 % of the study subjects had serum Se concentrations below 100 μg/l and 60 % had serum Se concentration below 90 μg/l, suggesting that Se status in many subjects was inadequate for maximal GPx activity. This was supported by the positive association between serum Se and serum GPx (P < 0·001), indicating that enzyme activity was limited by Se concentrations. The lowest mean serum Se concentrations were observed in the oldest age ranges; however, the prevalence of marginal Se status was similar across age ranges and did not appear to be influenced by sex or socio-economic status. The prevalence of marginal Se status was high in all sex and age subgroups, suggesting that the northern Tasmanian population could benefit from increasing Se intakes.

  12. Marginal longitudinal semiparametric regression via penalized splines. (United States)

    Kadiri, M Al; Carroll, R J; Wand, M P


    We study the marginal longitudinal nonparametric regression problem and some of its semiparametric extensions. We point out that, while several elaborate proposals for efficient estimation have been proposed, a relative simple and straightforward one, based on penalized splines, has not. After describing our approach, we then explain how Gibbs sampling and the BUGS software can be used to achieve quick and effective implementation. Illustrations are provided for nonparametric regression and additive models.

  13. Ocean Margins Programs, Phase I research summaries

    Energy Technology Data Exchange (ETDEWEB)

    Verity, P. [ed.


    During FY 1992, the DOE restructured its regional coastal-ocean programs into a new Ocean Margins Program (OMP), to: Quantify the ecological and biogeochemical processes and mechanisms that affect the cycling, flux, and storage of carbon and other biogenic elements at the land/ocean interface; Define ocean-margin sources and sinks in global biogeochemical cycles, and; Determine whether continental shelves are quantitatively significant in removing carbon dioxide from the atmosphere and isolating it via burial in sediments or export to the interior ocean. Currently, the DOE Ocean Margins Program supports more than 70 principal and co-principal investigators, spanning more than 30 academic institutions. Research funded by the OMP amounted to about $6.9M in FY 1994. This document is a collection of abstracts summarizing the component projects of Phase I of the OMP. This phase included both research and technology development, and comprised projects of both two and three years duration. The attached abstracts describe the goals, methods, measurement scales, strengths and limitations, and status of each project, and level of support. Keywords are provided to index the various projects. The names, addresses, affiliations, and major areas of expertise of the investigators are provided in appendices.

  14. Origin and dynamics of depositionary subduction margins (United States)

    Vannucchi, Paola; Morgan, Jason P.; Silver, Eli; Kluesner, Jared


    Here we propose a new framework for forearc evolution that focuses on the potential feedbacks between subduction tectonics, sedimentation, and geomorphology that take place during an extreme event of subduction erosion. These feedbacks can lead to the creation of a “depositionary forearc,” a forearc structure that extends the traditional division of forearcs into accretionary or erosive subduction margins by demonstrating a mode of rapid basin accretion during an erosive event at a subduction margin. A depositionary mode of forearc evolution occurs when terrigenous sediments are deposited directly on the forearc while it is being removed from below by subduction erosion. In the most extreme case, an entire forearc can be removed by a single subduction erosion event followed by depositionary replacement without involving transfer of sediments from the incoming plate. We need to further recognize that subduction forearcs are often shaped by interactions between slow, long-term processes, and sudden extreme events reflecting the sudden influences of large-scale morphological variations in the incoming plate. Both types of processes contribute to the large-scale architecture of the forearc, with extreme events associated with a replacive depositionary mode that rapidly creates sections of a typical forearc margin. The persistent upward diversion of the megathrust is likely to affect its geometry, frictional nature, and hydrogeology. Therefore, the stresses along the fault and individual earthquake rupture characteristics are also expected to be more variable in these erosive systems than in systems with long-lived megathrust surfaces.

  15. Origin and dynamics of depositionary subduction margins (United States)

    Vannucchi, Paola; Morgan, Jason P.; Silver, Eli A.; Kluesner, Jared W.


    Here we propose a new framework for forearc evolution that focuses on the potential feedbacks between subduction tectonics, sedimentation, and geomorphology that take place during an extreme event of subduction erosion. These feedbacks can lead to the creation of a "depositionary forearc," a forearc structure that extends the traditional division of forearcs into accretionary or erosive subduction margins by demonstrating a mode of rapid basin accretion during an erosive event at a subduction margin. A depositionary mode of forearc evolution occurs when terrigenous sediments are deposited directly on the forearc while it is being removed from below by subduction erosion. In the most extreme case, an entire forearc can be removed by a single subduction erosion event followed by depositionary replacement without involving transfer of sediments from the incoming plate. We need to further recognize that subduction forearcs are often shaped by interactions between slow, long-term processes, and sudden extreme events reflecting the sudden influences of large-scale morphological variations in the incoming plate. Both types of processes contribute to the large-scale architecture of the forearc, with extreme events associated with a replacive depositionary mode that rapidly creates sections of a typical forearc margin. The persistent upward diversion of the megathrust is likely to affect its geometry, frictional nature, and hydrogeology. Therefore, the stresses along the fault and individual earthquake rupture characteristics are also expected to be more variable in these erosive systems than in systems with long-lived megathrust surfaces.

  16. Marginal historiography: on Stekel's account of things. (United States)

    Bos, Jaap


    Psychoanalytic historiography has been, and to a certain extent still is, written mainly from the victor's (Freud's) perspective. One of the first attempts to deliver an alternative account was published in 1926 by Wilhelm Stekel in a little-known paper entitled "On the History of the Analytical Movement," which he wrote in response to Freud's (1925) "An Autobiographical Study" as an attempt to supplement or even counter Freud's version. This paper offers a dialogical reading of Stekel's paper, focusing not on the question of whether or not Stekel was right, but on the problem of marginalization itself. What discursive processes contributed to the marginalization of Stekel's position, and in what sense could Stekel's paper be called an instance of self-marginalization? Analysing various intertextual links between Freud's and Stekel's accounts, the author finds that the two accounts were caught up in an antagonistic dialectic from which it was impossible to escape. Following this paper, an English translation of Stekel's 1926 account is presented here for the first time.

  17. Testing for conditional multiple marginal independence. (United States)

    Bilder, Christopher R; Loughin, Thomas M


    Survey respondents are often prompted to pick any number of responses from a set of possible responses. Categorical variables that summarize this kind of data are called pick any/c variables. Counts from surveys that contain a pick any/c variable along with a group variable (r levels) and stratification variable (q levels) can be marginally summarized into an r x c x q contingency table. A question that may naturally arise from this setup is to determine if the group and pick any/c variable are marginally independent given the stratification variable. A test for conditional multiple marginal independence (CMMI) can be used to answer this question. Since subjects may pick any number out of c possible responses, the Cochran (1954, Biometrics 10, 417-451) and Mantel and Haenszel (1959, Journal of the National Cancer Institute 22, 719-748) tests cannot be used directly because they assume that units in the contingency table are independent of each other. Therefore, new testing methods are developed. Cochran's test statistic is extended to r x 2 x q tables, and a modified version of this statistic is proposed to test CMMI. Its sampling distribution can be approximated through bootstrapping. Other CMMI testing methods discussed are bootstrap p-value combination methods and Bonferroni adjustments. Simulation findings suggest that the proposed bootstrap procedures and the Bonferroni adjustments consistently hold the correct size and provide power against various alternatives.

  18. Intraoperative radiological margin assessment in breast-conserving surgery. (United States)

    Ihrai, T; Quaranta, D; Fouche, Y; Machiavello, J-C; Raoust, I; Chapellier, C; Maestro, C; Marcy, M; Ferrero, J-M; Flipo, B


    A prospective study was lead in order to analyze the accuracy of an X-ray device settled in the operating room for margin assessment, when performing breast-conserving surgery. One hundred and seventy patients were included. All lesions were visible on the preoperative mammograms. An intraoperative X-ray of the lumpectomy specimen was systematically performed for margins assessment. Final histological data were collected and the accuracy of intraoperative specimen radiography (IOSR) for margin assessment was analyzed. IOSR allowed an evaluation of margins status in 155 cases (91.2%). After final histological examination, the positive margins rate would have been 6.5% if margin assessment had relied only on IOSR. Margin assessment with a two-dimensional X-ray device would have allowed the achievement of negative margins in 93.5% of the cases. Moreover, this procedure allows important time-saving and could have a substantial economical impact. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. Intraoperative ultrasound control of surgical margins during partial nephrectomy

    Directory of Open Access Journals (Sweden)

    Feras M Alharbi


    Conclusions: The intraoperative US control of resection margins in PN is a simple, efficient, and effective method for ensuring negative surgical margins with a small increase in warm ischemia time and can be conducted by the operating urologist.

  20. Some Comments on Tectonic Erosion and Sediment Subduction in Convergent Margins (United States)

    Clift, P. D.; Vannucchi, P.


    Subduction plate boundaries at which tectonic erosion removes material from the overriding plate account for 57% of the total length of the global subduction system are favored where convergence rates exceed about 6 cm/yr and where the sedimentary cover is less than 1 km. Accretion conversely preferentially occurs in regions of slow orthogonal convergence (1 km. The slope gradients and taper angle of accretionary plate margins correlates with plate convergence rates, while erosive margin slopes appear to be independent of this. Rates of trench retreat do not appear to correlate with any simple characteristic of the plate interaction, but are largely a function of the history of seamount or ridge collisions. 55% of the total continental crustal material subducted globally below forearc regions in the modern ocean comprises material removed by tectonic erosion from the over-riding plate, 45% trench sediment. Even in accretionary margins a median of only 17% of the incoming sedimentary mass is accreted over time scales of 10 my or greater, resulting in long-term net loss of continental crust along convergent margins. Average magmatic productivity in the active margins must exceed 90 km3/my to preserve the current volume of the continental crust. Geological arguments indicate that magmatic accretion rates must be faster in oceanic arcs (91-149 km3/my) and less in the continental arcs (27-135 km3/my). Mass balance arguments in oceanic arcs require that their crustal thicknesses must be Continental growth is principally achieved through the collision of oceanic island arcs to continental margins. Although oceanic arcs are chemically distinct from continental crust, the collision process involves the loss of mafic and ultramafic lower crust and the emplacement of voluminous, high silica, light rare earth element enriched melts, transforming the net composition into something more continental in character.

  1. Do Robotic Surgical Systems Improve Profit Margins? A Cross-Sectional Analysis of California Hospitals. (United States)

    Shih, Ya-Chen Tina; Shen, Chan; Hu, Jim C


    The aim of this study was to examine the association between ownership of robotic surgical systems and hospital profit margins. This study used hospital annual utilization data, annual financial data, and discharge data for year 2011 from the California Office of Statewide Health Planning and Development. We first performed bivariate analysis to compare mean profit margin by hospital and market characteristics and to examine whether these characteristics differed between hospitals that had one or more robotic surgical systems in 2011 and those that did not. We applied the t test and the F test to compare mean profit margin between two groups and among three or more groups, respectively. We then conducted multilevel logistic regression to determine the association between ownership of robotic surgical systems and having a positive profit margin after controlling for other hospital and market characteristics and accounting for possible correlation among hospitals located within the same market. The study sample included 167 California hospitals with valid financial information. Hospitals with robotic surgical systems tended to report more favorable profit margins. However, multilevel logistic regression showed that this relationship (an association, not causality) became only marginally significant (odds ratio [OR] = 6.2; P = 0.053) after controlling for other hospital characteristics, such as ownership type, teaching status, bed size, and surgical volumes, and market characteristics, such as total number of robotic surgical systems owned by other hospitals in the same market area. As robotic surgical systems become widely disseminated, hospital decision makers should carefully evaluate the financial and clinical implications before making a capital investment in this technology. Copyright © 2017 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  2. Observations at convergent margins concerning sediment subduction, subduction erosion, and the growth of continental crust (United States)

    Von Huene, R.; Scholl, D. W.


    subducted beneath the frontal accretionary body and its active buttress. In rounded figures the contemporary rate of solid-volume sediment subduction at convergent ocean margins (???43,500 km) is calculated to be 1.5 km3/yr. Correcting type 1 margins for high rates of terrigenous seafloor sedimentation during the past 30 m.y. or so sets the long-term rate of sediment subduction at 1.0 km3/yr. The bulk of the subducted material is derived directly or indirectly from continental denudation. Interstitial water currently expulsed from accreted and deeply subducted sediment and recycled to the ocean basins is estimated at 0.9 km3/yr. The thinning and truncation caused by subduction erosion of the margin's framework rock and overlying sedimentary deposits have been demonstrated at many convergent margins but only off northern Japan, central Peru, and northern Chile has sufficient information been collected to determine average or long-term rates, which range from 25 to 50 km3/m.y. per kilometer of margin. A conservative long-term rate applicable to many sectors of convergent margins is 30 km3/km/m.y. If applied to the length of type 2 margins, subduction erosion removes and transports approximately 0.6 km3/yr of upper plate material to greater depths. At various places, subduction erosion also affects sectors of type 1 margins bordered by small- to medium-sized accretionary prisms (for example, Japan and Peru), thus increasing the global rate by possibly 0.5 km3/yr to a total of 1.1 km3/yr. Little information is available to assess subduction erosion at margins bordered by large accretionary prisms. Mass balance calculations allow assessments to be made of the amount of subducted sediment that bypasses the prism and underthrusts the margin's rock framework. This subcrustally subducted sediment is estimated at 0.7 km3/yr. Combined with the range of terrestrial matter removed from the margin's rock framework by subduction erosion, the global volume of subcrustally subducted materia

  3. Renormalized Volume

    CERN Document Server

    Gover, A Rod


    For any conformally compact manifold with hypersurface boundary we define a canonical renormalized volume functional and compute an explicit, holographic formula for the corresponding anomaly. For the special case of asymptotically Einstein manifolds, our method recovers the known results. The anomaly does not depend on any particular choice of regulator, but the coefficients of divergences do. We give explicit formulae for these divergences valid for any choice of regulating hypersurface; these should be relevant to recent studies of quantum corrections to entanglement entropies. The anomaly is expressed as a conformally invariant integral of a local Q-curvature that generalizes the Branson Q-curvature by including data of the embedding. In each dimension this canonically defines a higher dimensional generalization of the Willmore energy/rigid string action. We show that the variation of these energy functionals is exactly the obstruction to solving a singular Yamabe type problem with boundary data along the...

  4. Static jaw collimation settings to minimize radiation dose to normal brain tissue during stereotactic radiosurgery

    Energy Technology Data Exchange (ETDEWEB)

    Han, Eun Young, E-mail: [Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR (United States); Zhang Xin; Yan Yulong; Sharma, Sunil; Penagaricano, Jose [Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR (United States); Moros, Eduardo [Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL (United States); Corry, Peter [Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR (United States)


    At University of Arkansas for Medical Sciences (UAMS) intracranial stereotactic radiosurgery (SRS) is performed by using a linear accelerator with an add-on micromultileaf collimator (mMLC). In our clinical setting, static jaws are automatically adapted to the furthest edge of the mMLC-defined segments with 2-mm (X jaw) and 5-mm (Y jaw) margin and the same jaw values are applied for all beam angles in the treatment planning system. This additional field gap between the static jaws and the mMLC allows additional radiation dose to normal brain tissue. Because a radiosurgery procedure consists of a single high dose to the planning target volume (PTV), reduction of unnecessary dose to normal brain tissue near the PTV is important, particularly for pediatric patients whose brains are still developing or when a critical organ, such as the optic chiasm, is near the PTV. The purpose of this study was to minimize dose to normal brain tissue by allowing minimal static jaw margin around the mMLC-defined fields and different static jaw values for each beam angle or arc. Dose output factors were measured with various static jaw margins and the results were compared with calculated doses in the treatment planning system. Ten patient plans were randomly selected and recalculated with zero static jaw margins without changing other parameters. Changes of PTV coverage, mean dose to predefined normal brain tissue volume adjacent to PTV, and monitor units were compared. It was found that the dose output percentage difference varied from 4.9-1.3% for the maximum static jaw opening vs. static jaw with zero margins. The mean dose to normal brain tissue at risk adjacent to the PTV was reduced by an average of 1.9%, with negligible PTV coverage loss. This dose reduction strategy may be meaningful in terms of late effects of radiation, particularly in pediatric patients. This study generated clinical knowledge and tools to consistently minimize dose to normal brain tissue.

  5. Marginal phase correction of truncated Bessel beams (United States)



    Approximate analytic expressions are obtained for evaluating the axial intensity and the central-lobe diameter of J0 Bessel beams transmitted through a finite-aperture phase filter. A reasonable quality factor governing the axial-intensity behavior of a phase-undistorted truncated Bessel beam is found to be the inverse square root of the Fresnel number defined, for a given aperture, from the axial point of geometrical shadow. Additional drastic reduction of axial-intensity oscillations is accomplished by using marginal phase correction of the beam instead of the well-known amplitude apodization. A procedure for analytically calculating an optimal monotonic slowly varying correction phase function is described.

  6. Potentials of marginal lands - sponateous ecosystem development (United States)

    Gerwin, Werner; Schaaf, Wolfgang


    Marginal lands are often considered as unfertile and not productive. They are widely excluded from modern land use by conventional agriculture. Assessment of soil fertility usually shows very low productivity potentials at least for growing traditional crops. However, it can be frequently observed that natural succession at different types of marginal lands leads to very diverse and nonetheless productive ecosystems. Examples can be found at abandoned former industrial or transportation sites which were set aside and not further maintained - and also in post-mining landscapes. In one of the lignite open cast mines of the State of Brandenburg in Eastern Germany a landscape observatory was established in 2005 for observing this natural ecosystem development under marginal site conditions. The site of 6 ha is part of the post-mining landscapes of Lusatia which are often characterized by poor soil conditions and clearly reduced soil fertility. It is named "Hühnerwasser-Quellgebiet" (Chicken Creek Catchment) after a small stream that is restored again after destruction by the mining operations. It is planned to serve as the headwater of this stream and was left to an unrestricted primary succession. A comprehensive scientific monitoring program is carried out since the start of ecosystem development in 2005. The results offer exemplary insights into the establishment of interaction networks between the developing ecosystem compartments. After 10 years a large biodiversity, expressed by a high number of species, can be found at this site as the result of natural recovery processes. A large number of both tree species and individuals have settled here. Even if no economic use of the site and of the woody biomass produced by these trees is planned, an overall assessment of the biomass production was carried out. The results showed that the biomass production from natural succession without any application of fertilizers etc. is directly comparable with yields from

  7. Area inequalities for stable marginally trapped surfaces

    CERN Document Server

    Jaramillo, José Luis


    We discuss a family of inequalities involving the area, angular momentum and charges of stably outermost marginally trapped surfaces in generic non-vacuum dynamical spacetimes, with non-negative cosmological constant and matter sources satisfying the dominant energy condition. These inequalities provide lower bounds for the area of spatial sections of dynamical trapping horizons, namely hypersurfaces offering quasi-local models of black hole horizons. In particular, these inequalities represent particular examples of the extension to a Lorentzian setting of tools employed in the discussion of minimal surfaces in Riemannian contexts.

  8. A dosimetric comparison of 3D-CRT, IMRT, and static tomotherapy with an SIB for large and small breast volumes

    Energy Technology Data Exchange (ETDEWEB)

    Michalski, Andrea [Department of Health Science (MRS), The University of Sydney, Lidcombe, New South Wales (Australia); Central Coast Cancer Centre, Gosford Hospital, Gosford, New South Wales (Australia); Atyeo, John, E-mail: [Department of Health Science (MRS), The University of Sydney, Lidcombe, New South Wales (Australia); Cox, Jennifer [Department of Health Science (MRS), The University of Sydney, Lidcombe, New South Wales (Australia); Department of Radiation Oncology, Royal North Shore Hospital, St Leonards, New South Wales (Australia); Rinks, Marianne [Department of Health Science (MRS), The University of Sydney, Lidcombe, New South Wales (Australia); Radiation Oncology, Cancer Services, Illawarra Shoalhaven Local Health District, Wollongong, New South Wales (Australia); Morgia, Marita; Lamoury, Gillian [Department of Radiation Oncology, Royal North Shore Hospital, St Leonards, New South Wales (Australia)


    Radiation therapy to the breast is a complex task, with many different techniques that can be employed to ensure adequate dose target coverage while minimizing doses to the organs at risk. This study compares the dose planning outcomes of 3 radiation treatment modalities, 3 dimensional conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT), and static tomotherapy, for left-sided whole-breast radiation treatment with a simultaneous integrated boost (SIB). Overall, 20 patients with left-sided breast cancer were separated into 2 cohorts, small and large, based on breast volume. Dose plans were produced for each patient using 3D-CRT, IMRT, and static tomotherapy. All patients were prescribed a dose of 45 Gy in 20 fractions to the breast with an SIB of 56 Gy in 20 fractions to the tumor bed and normalized so that D{sub 98%} > 95% of the prescription dose. Dosimetric comparisons were made between the 3 modalities and the interaction of patient size. All 3 modalities offered adequate planning target volume (PTV) coverage with D{sub 98%} > 95% and D{sub 2%} < 107%. Static tomotherapy offered significantly improved (p = 0.006) dose homogeneity to the PTV{sub boost} {sub eval} (0.079 ± 0.011) and breast minus the SIB volume (Breast{sub SIB}) (p < 0.001, 0.15 ± 0.03) compared with the PTV{sub boost} {sub eval} (0.085 ± 0.008, 0.088 ± 0.12) and Breast{sub SIB} (0.22 ± 0.05, 0.23 ± 0.03) for IMRT and 3D-CRT, respectively. Static tomotherapy also offered statistically significant reductions (p < 0.001) in doses to the ipsilateral lung mean dose of 6.79 ± 2.11 Gy compared with 7.75 ± 2.54 Gy and 8.29 ± 2.76 Gy for IMRT and 3D-CRT, respectively, and significantly (p < 0.001) reduced heart doses (mean = 2.83 ± 1.26 Gy) compared to both IMRT and 3D-CRT (mean = 3.70 ± 1.44 Gy and 3.91 ± 1.58 Gy). Static tomotherapy is the dosimetrically superior modality for the whole breast with an SIB compared with IMRT and 3D-CRT. IMRT is superior to 3D

  9. Dose-volume histogram comparison between static 5-field IMRT with 18-MV X-rays and helical tomotherapy with 6-MV X-rays. (United States)

    Hayashi, Akihiro; Shibamoto, Yuta; Hattori, Yukiko; Tamura, Takeshi; Iwabuchi, Michio; Otsuka, Shinya; Sugie, Chikao; Yanagi, Takeshi


    We treated prostate cancer patients with static 5-field intensity-modulated radiation therapy (IMRT) using linac 18-MV X-rays or tomotherapy with 6-MV X-rays. As X-ray energies differ, we hypothesized that 18-MV photon IMRT may be better for large patients and tomotherapy may be more suitable for small patients. Thus, we compared dose-volume parameters for the planning target volume (PTV) and organs at risk (OARs) in 59 patients with T1-3 N0M0 prostate cancer who had been treated using 5-field IMRT. For these same patients, tomotherapy plans were also prepared for comparison. In addition, plans of 18 patients who were actually treated with tomotherapy were analyzed. The evaluated parameters were homogeneity indicies and a conformity index for the PTVs, and D2 (dose received by 2% of the PTV in Gy), D98, Dmean and V10-70 Gy (%) for OARs. To evaluate differences by body size, patients with a known body mass index were grouped by that index ( 25 kg/m(2)). For the PTV, all parameters were higher in the tomotherapy plans compared with the 5-field IMRT plans. For the rectum, V10 Gy and V60 Gy were higher, whereas V20 Gy and V30 Gy were lower in the tomotherapy plans. For the bladder, all parameters were higher in the tomotherapy plans. However, both plans were considered clinically acceptable. Similar trends were observed in 18 patients treated with tomotherapy. Obvious trends were not observed for body size. Tomotherapy provides equivalent dose distributions for PTVs and OARs compared with 18-MV 5-field IMRT. Tomotherapy could be used as a substitute for high-energy photon IMRT for prostate cancer regardless of body size.

  10. Characteristics of positive surgical margins in robotic-assisted radical prostatectomy, open retropubic radical prostatectomy, and laparoscopic radical prostatectomy: a comparative histopathologic study from a single academic center. (United States)

    Albadine, Roula; Hyndman, Matthew E; Chaux, Alcides; Jeong, J Y; Saab, Shahrazad; Tavora, Fabio; Epstein, Jonathan I; Gonzalgo, Mark L; Pavlovich, Christian P; Netto, George J


    Studies detailing differences in positive surgical margin among open retropubic radical prostatectomy, laparoscopic radical prostatectomy, and robotic-assisted laparoscopic radical prostatectomy are lacking. A retrospective review of all prostatectomies with positive surgical margin performed at our center in 2007 disclosed 99 cases, 6 (5%) of which were reinterpreted cases as having negative margins. Ninety-three cases were, therefore, included, corresponding to 37 retropubic radical prostatectomies, 19 laparoscopic radical prostatectomies, and 37 robotic-assisted laparoscopic radical prostatectomies. The relationship of positive surgical margin characteristics to clinicopathologic parameters and biochemical recurrence was assessed. The most commonly found positive surgical margin site was the apex/distal third in all groups (62% retropubic prostatectomies, 79% laparoscopic prostatectomies, 60% robotic-assisted prostatectomies). Total linear length of positive surgical margin sites was significantly correlated with preoperative prostate-specific antigen, preoperative prostate-specific antigen density, pT stage, and tumor volume (P ≤ .001). We found no significant differences among the 3 groups with respect to total linear length, number of foci, laterality, or location of positive surgical margin. The rate of biochemical recurrence was also comparable in the 3 groups. On univariate analyses, biochemical recurrence was significantly associated with preoperative prostate-specific antigen values, preoperative prostate-specific antigen density, Gleason score, number of positive surgical margins, and total linear length of positive surgical margin (P ≤ .02). Only preoperative prostate-specific antigen density and number of positive surgical margin foci were statistically significant (P ≤ .03) independent predictors of biochemical recurrence. We found no significant difference in positive surgical margin characteristics or biochemical recurrence among the 3

  11. Formation and evolution of magma-poor margins, an example of the West Iberia margin (United States)

    Perez-Gussinye, Marta; Andres-Martinez, Miguel; Morgan, Jason P.; Ranero, Cesar R.; Reston, Tim


    The West Iberia-Newfoundland (WIM-NF) conjugate margins have been geophysically and geologically surveyed for the last 30 years and have arguably become a paradigm for magma-poor extensional margins. Here we present a coherent picture of the WIM-NF rift to drift evolution that emerges from these observations and numerical modeling, and point out important differences that may exist with other magma-poor margins world-wide. The WIM-NF is characterized by a continental crust that thins asymmetrically and a wide and symmetric continent-ocean transition (COT) interpreted to consist of exhumed and serpentinised mantle with magmatic products increasing oceanward. The architectural evolution of these margins is mainly dominated by cooling under very slow extension velocities (crust that most probably was not extremely weak at the start of rifting. These conditions lead to a system where initially deformation is distributed over a broad area and the upper, lower crust and lithosphere are decoupled. As extension progresses upper, lower, crust and mantle become tightly coupled and deformation localizes due to strengthening and cooling during rifting. Coupling leads to asymmetric asthenospheric uplift and weakening of the hanginwall of the active fault, where a new fault forms. This continued process leads to the formation of an array of sequential faults that dip and become younger oceanward. Here we show that these processes acting in concert: 1) reproduce the margin asymmetry observed at the WIM-NF, 2) explain the fault geometry evolution from planar, to listric to detachment like by having one common Andersonian framework, 3) lead to the symmetric exhumation of mantle with little magmatism, and 4) explain the younging of the syn-rift towards the basin centre and imply that unconformities separating syn- and post-rift may be diachronous and younger towards the ocean. Finally, we show that different lower crustal rheologies lead to different patterns of extension and to an

  12. Recidiva tardia de linfoma da zona marginal Late relapse of marginal zone lymphoma


    Rocha,Talita M. B.S.; Bortolheiro,Tereza C.; Eduardo Costa; Daniela Haardt; Roberto P. Paes; Chiattone, Carlos S.


    O linfoma de zona marginal é um linfoma de baixo grau com curso clínico indolente e potencial de recidiva.1,2 Apresentamos um caso de recidiva tardia após 25 anos de aparente remissão completa, levantando a possibilidade de recidiva de doença preexistente ou desenvolvimento de novo clone neoplásico.Marginal zone lymphoma is a low grade lymphoma with an indolent course and chance to relapse. We present a case of a patient who suffered relapse after 25 years of apparently complete remission of ...

  13. Characterizing entanglement with global and marginal entropic measures

    CERN Document Server

    Adesso, G; De Siena, S; Adesso, Gerardo; Illuminati, Fabrizio; Siena, Silvio De


    We qualify the entanglement of arbitrary mixed states of bipartite quantum systems by comparing global and marginal mixednesses quantified by different entropic measures. For systems of two qubits we discriminate the class of maximally entangled states with fixed marginal mixednesses, and determine an analytical upper bound relating the entanglement of formation to the marginal linear entropies. This result partially generalizes to mixed states the quantification of entaglement with marginal mixednesses holding for pure states. We identify a class of entangled states that, for fixed marginals, are globally more mixed than product states when measured by the linear entropy. Such states cannot be discriminated by the majorization criterion.

  14. Research priorities for zoonoses and marginalized infections. (United States)


    This report provides a review and analysis of the research landscape for zoonoses and marginalized infections which affect poor populations, and a list of research priorities to support disease control. The work is the output of the Disease Reference Group on Zoonoses and Marginalized Infectious Diseases of Poverty (DRG6), which is part of an independent think tank of international experts, established and funded by the Special Programme for Research and Training in Tropical Diseases (TDR), to identify key research priorities through review of research evidence and input from stakeholder consultations. The report covers a diverse range of diseases, including zoonotic helminth, protozoan, viral and bacterial infections considered to be neglected and associated with poverty. Disease-specific research issues are elaborated under individual disease sections and many common priorities are identified among the diseases such as the need for new and/or improved drugs and regimens, diagnostics and, where appropriate, vaccines. The disease-specific priorities are described as micro priorities compared with the macro level priorities which will drive policy-making for: improved surveillance; interaction between the health, livestock, agriculture, natural resources and wildlife sectors in tackling zoonotic diseases; and true assessment of the burden of zoonoses. This is one often disease and thematic reference group reports that have come out of the TDR Think Tank, all of which have contributed to the development of the Global Report search on Infectious Diseases of Poverty, available at:

  15. Instability and Tsunamigenic Potential at Convergent Margins (United States)

    von Huene, R.; Ranero, C. R.; Watts, P.


    Along many convergent margins multibeam echosounding navigated with GPS has revealed large slope failures that were probably tsunamigenic. Bathymetric data combined with seismic reflection imaging indicate multiple causes. The 55-km wide Nicoya Slump resulted from the steepening slope above an underthrusting seamount on the subducting oceanic plate. This slump may have generated a 27-m high wave. Several 5-7 km wide mid-slope slides off central Nicaragua probably resulted from steepening of the continental slope by tectonic erosion. They may have generated waves 6-7 m high. A 30 km wide mid-slope slump off northern Peru may have generated a 5 m high wave. Its cause will not be understood without better seismic reflection imaging but considerable fluid venting was observed across its headwall. In the Gulf of Alaska a large slide appears to have resulted from rapid sedimentation. Tsunamigenic slope failure along convergent margins is only beginning to be resolved and the causes vary. Subducted ocean floor relief, tectonically steepened slopes, and sites of rapid sedimentation can help target potential failure and possible future tsunami hazards.

  16. Large margin classifier-based ensemble tracking (United States)

    Wang, Yuru; Liu, Qiaoyuan; Yin, Minghao; Wang, ShengSheng


    In recent years, many studies consider visual tracking as a two-class classification problem. The key problem is to construct a classifier with sufficient accuracy in distinguishing the target from its background and sufficient generalize ability in handling new frames. However, the variable tracking conditions challenges the existing methods. The difficulty mainly comes from the confused boundary between the foreground and background. This paper handles this difficulty by generalizing the classifier's learning step. By introducing the distribution data of samples, the classifier learns more essential characteristics in discriminating the two classes. Specifically, the samples are represented in a multiscale visual model. For features with different scales, several large margin distribution machine (LDMs) with adaptive kernels are combined in a Baysian way as a strong classifier. Where, in order to improve the accuracy and generalization ability, not only the margin distance but also the sample distribution is optimized in the learning step. Comprehensive experiments are performed on several challenging video sequences, through parameter analysis and field comparison, the proposed LDM combined ensemble tracker is demonstrated to perform with sufficient accuracy and generalize ability in handling various typical tracking difficulties.

  17. Limit theorems for functions of marginal quantiles

    CERN Document Server

    Babu, G Jogesh; Choi, Kwok Pui; Mangalam, Vasudevan; 10.3150/10-BEJ287


    Multivariate distributions are explored using the joint distributions of marginal sample quantiles. Limit theory for the mean of a function of order statistics is presented. The results include a multivariate central limit theorem and a strong law of large numbers. A result similar to Bahadur's representation of quantiles is established for the mean of a function of the marginal quantiles. In particular, it is shown that \\[\\sqrt{n}\\Biggl(\\frac{1}{n}\\sum_{i=1}^n\\phi\\bigl(X_{n:i}^{(1)},...,X_{n:i}^{(d)}\\bigr)-\\bar{\\gamma}\\Biggr)=\\frac{1}{\\sqrt{n}}\\sum_{i=1}^nZ_{n,i}+\\mathrm{o}_P(1)\\] as $n\\rightarrow\\infty$, where $\\bar{\\gamma}$ is a constant and $Z_{n,i}$ are i.i.d. random variables for each $n$. This leads to the central limit theorem. Weak convergence to a Gaussian process using equicontinuity of functions is indicated. The results are established under very general conditions. These conditions are shown to be satisfied in many commonly occurring situations.


    Directory of Open Access Journals (Sweden)

    A. Georgescu


    Full Text Available Premises: Sexual hormones may affect the general health condition of women, as early as puberty, continuing during pregnancy and also after menopause. Variations of the hormonal levels may cause different – either local or general – pathological modifications. Sexual hormones may also affect periodontal status, favourizing gingival inflammations and reducing periodontal resistance to the action of the bacterial plaque. Scope: Establishment of the correlations between the debut or the manifestation of menopause and the modifications produced in the superficial periodontium. Materials and method: Clinical and paraclinical investigations were performed on female patients with ages between 45 and 66 years, involving macroscopic, microscopic and radiological recording of the aspect of the superificial periodontium (gingiva. Results: Analysis of the histological sections evidenced atrophic and involutive modifications in the marginal superficial periodontium of female patients at menopause. Conclusions: Sexual hormones intervene in the histological equilibrium of the marginal superficial periodontium, influencing the periodontal health status, which explains the correlation between the subjective symptomatology specific to menopause and the histopatological aspect at epithelial level.

  19. Naturally light dilatons from nearly marginal deformations

    CERN Document Server

    Megias, Eugenio


    We discuss the presence of a light dilaton in CFTs deformed by a nearly-marginal operator O, in the holographic realizations consisting of confining RG flows that end on a soft wall. Generically, the deformations induce a condensate , and the dilaton mode can be identified as the fluctuation of . We obtain a mass formula for the dilaton as a certain average along the RG flow. The dilaton is naturally light whenever i) confinement is reached fast enough (such as via the condensation of O) and ii) the beta function is small (walking) at the condensation scale. These conditions are satisfied for a class of models with a bulk pseudo-Goldstone boson whose potential is nearly flat at small field and exponential at large field values. Thus, the recent observation by Contino, Pomarol and Ratazzi holds in CFTs with a single nearly-marginal operator. We also discuss the holographic method to compute the condensate , based on solving the first-order nonlinear differential equation that the beta function satisfies.

  20. Photogrammetric monitoring of glacier margin lakes

    Directory of Open Access Journals (Sweden)

    Christian Mulsow


    Full Text Available The growing number of glacier margin lakes that have developed due to glacier retreat have caused an increase of dangerous glacier lake outburst floods (GLOFs in several regions over the last decade. This normally causes a flood wave downstream the glacier. Typically, such an event takes few to several hours. GLOF scenarios may be a significant hazard to life, property, nature and infrastructure in the affected areas. A GLOF is usually characterized by a progressive water level drop. By observing the water level of the lake, an imminent GLOF-event can be identified. Common gauging systems are often not suitable for the measurement task, as they may be affected by ice fall or landslides in the lake basin. Therefore, in our pilot study, the water level is observed by processing images of a terrestrial camera system observing a glacier margin lake. The paper presents the basic principle of an automatic single-camera-based GLOF early warning system. Challenges and approaches to solve them are discussed. First, results from processed image sequences are presented to show the feasibility of the concept. Water level changes can be determined at decimetre precision.

  1. New results from a 3D seismic academic dataset across the west Galicia margin (United States)

    Lymer, Gaël; Cresswell, Derren; Reston, Tim; Stevenson, Carl; Sawyer, Dale


    The west Galicia margin (western Spain) is a magma-poor margin and has limited sedimentary cover, providing ideal conditions to study the processes of continental extension and break-up through seismic imaging. The margin is characterised by hyper-extended continental crust, well defined rotated faults blocks with associated syn-kinematic sedimentary wedges, and exhumed serpentinized continental mantle. Faulted blocks overlie a bright reflection, the S reflector, generally interpreted as both a detachment and the crust-mantle boundary. But open questions remain concerning the role of the S detachment in extension leading to breakup. To study further the S reflection and its role in continental breakup, a new 3D high-resolution multi-channel seismic dataset has been acquired over the Galicia margin during summer 2013. It consists in 800 inlines and 5000 crosslines distributed on a ~680 km2 areal. This 3D dataset is thus the largest academic one of its kind. It extends across the edge of the continental crust and captures the 3D nature of extension and break-up of the northern Atlantic continental margins. Here we present some results from our interpretations of the 3D volume, which allow various horizons, including the base of the post-rift sedimentary cover, the top basement and the S reflector, to be mapped out in 3D. These maps provide 3D views of the margin structure and also reveal the texture of each horizon. We also focus on the internal structure of some of the faulted blocks through interpretation of the crustal normal faults. The main normal faults are generally connected downward on the S reflector, revealing strong interactions between crustal thinning and the S. The half-grabens and the fault blocks are dominantly N-S oriented, but the crustal structures vary both along strike and cross strike. We particularly observe an intriguingly NW-SE trend, highlighted by a pronounced low within the crest of the fault blocks. We also observe this trend from

  2. The Role of Weight Shrinking in Large Margin Perceptron Learning

    CERN Document Server

    Panagiotakopoulos, Constantinos


    We introduce into the classical perceptron algorithm with margin a mechanism that shrinks the current weight vector as a first step of the update. If the shrinking factor is constant the resulting algorithm may be regarded as a margin-error-driven version of NORMA with constant learning rate. In this case we show that the allowed strength of shrinking depends on the value of the maximum margin. We also consider variable shrinking factors for which there is no such dependence. In both cases we obtain new generalizations of the perceptron with margin able to provably attain in a finite number of steps any desirable approximation of the maximal margin hyperplane. The new approximate maximum margin classifiers appear experimentally to be very competitive in 2-norm soft margin tasks involving linear kernels.

  3. Continental margin radiography from a potential field and sediment thickness standpoint: the Iberian Atlantic Margin

    Energy Technology Data Exchange (ETDEWEB)

    Catalan, M.; Martos, Y. M.; Martin-Davila, J.; Munoz-Martin, A.; Carbo, A.; Druet, M.


    This study reviews the state of knowledge in the Iberian Atlantic margin. In order to do this, the margin has been divided into three provinces: the Galicia margin, the southern Iberian abyssal plain, and the Tagus abyssal plain. We have used potential field and sediment thickness data. This has allowed us to study the crust, setting limits for the continental crust domain, and the amplitude of the so-called ocean-continent transition, whose end marks the beginning of the oceanic crust. The study shows the continental crust in the Galician margin to be the widest, about 210 km in length, whilst the ocean-continent transition varies slightly in this province: between 65 km wide in the south and 56 km wide in the north. This result shows up some differences with the hypothesis of other authors. The situation in the southern Iberian abyssal plain is nearly the opposite. Its continental crust extends approximately 60 km, whilst the ocean-continent transition zone is 185 km long. The Tagus abyssal plain study shows a faster morphological evolution than the others, according with the amount of crustal thinning β, the ocean-continent transition domain spanning 100 km. These results support a transitional intermediate character for almost the whole Tagus plain, in contrary to what other authors have stated. (Author)

  4. The tragedy of the margins: land rights and marginal lands in Vietnam (c. 1800-1945)

    NARCIS (Netherlands)

    J. Kleinen


    This article deals with aspects of official land registers in pre-colonial and colonial Vietnam and their relationship with marginal lands since the eleventh century and especially since the beginning of the nineteenth century. The changing pattern of land ownership and control is studied in detail

  5. Talking (and Not Talking) about Race, Social Class and Dis/Ability: Working Margin to Margin (United States)

    Ferri, Beth A.; Connor, David J.


    In this article we examine some of the omnipresent yet unacknowledged discourses of social and economic disadvantage and dis/ability within schools in the US. First, we document ways that social class, race, and dis/ability function within schools to further disadvantage and exclude already marginalized students. Next, we show how particular ways…

  6. Tectonic-sedimentary evolution of the eastern Brazilian marginal basins: Implications in their petroleum systems

    Energy Technology Data Exchange (ETDEWEB)

    Francisco, N.F.; Azambuja, N.C.; Mello, M.R. (Petrobras, Rio de Janeiro (Brazil))


    A geological survey of eastern Brazilian marginal basins using sedimentological, tectonic and geochemical data has been carried out. The almost 4000 km long set of basins can be classified as component of a typical divergent, mature Atlantic-continental margin. Based on their tectonic-sedimentary sequence, they can be linked to a single evolutionary history, which can be divided in three main stages: pre-rift, rift, and drift. The integration of all data allowed the characterization of two major petroleum systems that represent about 90% of the known Brazilian hydrocarbons reserves: (1) the rift (Early Cretaceous) and the drift (Late Cretaceous-Paleogene). With respect to the oil-in-place volume and production, the most significant one is the drift system associated with the siliciclastic deep water turbidites reservoirs deposited in bathyal environments. Such reservoirs are clearly controlled by a favorable relationship of stratigraphic and tectonic settings.

  7. Evidence for Marginal Stability in Emulsions (United States)

    Lin, Jie; Jorjadze, Ivane; Pontani, Lea-Laetitia; Wyart, Matthieu; Brujic, Jasna


    We report the first measurements of the effect of pressure on vibrational modes in emulsions, which serve as a model for soft frictionless spheres at zero temperature. As a function of the applied pressure, we find that the density of states D (ω ) exhibits a low-frequency cutoff ω*, which scales linearly with the number of extra contacts per particle δ z . Moreover, for ω Soft Matter 10, 5628 (2014); S. Franz, G. Parisi, P. Urbani, and F. Zamponi, Proc. Natl. Acad. Sci. U.S.A. 112, 14539 (2015)]. Finally, the degree of localization of the softest low frequency modes increases with compression, as shown by the participation ratio as well as their spatial configurations. Overall, our observations show that emulsions are marginally stable and display non-plane-wave modes up to vanishing frequencies.

  8. Regnar -- Development of a marginal field

    Energy Technology Data Exchange (ETDEWEB)

    Thalund, K.M.; Brodersen, F.P.; Roigaard-Petersen, B. [Maersk Olie og Gas AS, Copenhagen (Denmark)


    Regnar is a small marginal field located some 13 km from the main Dan F complex and is the first subsea completion in Danish waters, operated by Maersk Olie og Gas AS. A short lifetime has been predicted for the field which therefore has been developed as a low cost project, using a combination of subsea technology and minimum topside facilities. Regnar consists of a subsea x-mas tree producing through a 6 inch pipeline with a 2 1/2 inch chemical piggyback line to Dan F. The x-mas tree and the subsea choke valve are controlled from a buoy moored nearby the well. The buoy is radio linked to Dan F. The Regnar field was brought on stream on September 26, 1993.

  9. Max-margin based Bayesian classifier

    Institute of Scientific and Technical Information of China (English)

    Tao-cheng HU‡; Jin-hui YU


    There is a tradeoff between generalization capability and computational overhead in multi-class learning. We propose a generative probabilistic multi-class classifi er, considering both the generalization capability and the learning/prediction rate. We show that the classifi er has a max-margin property. Thus, prediction on future unseen data can nearly achieve the same performance as in the training stage. In addition, local variables are eliminated, which greatly simplifi es the optimization problem. By convex and probabilistic analysis, an efficient online learning algorithm is developed. The algorithm aggregates rather than averages dualities, which is different from the classical situations. Empirical results indicate that our method has a good generalization capability and coverage rate.


    Energy Technology Data Exchange (ETDEWEB)

    Mason M. Medizade; John R. Ridgely; Donald G. Nelson


    A marginal expense oil well wireless surveillance system to monitor system performance and production from rod-pumped wells in real time from wells operated by Vaquero Energy in the Edison Field, Main Area of Kern County in California has been successfully designed and field tested. The surveillance system includes a proprietary flow sensor, a programmable transmitting unit, a base receiver and receiving antenna, and a base station computer equipped with software to interpret the data. First, the system design is presented. Second, field data obtained from three wells is shown. Results of the study show that an effective, cost competitive, real-time wireless surveillance system can be introduced to oil fields across the United States and the world.

  11. The genetics of nodal marginal zone lymphoma. (United States)

    Spina, Valeria; Khiabanian, Hossein; Messina, Monica; Monti, Sara; Cascione, Luciano; Bruscaggin, Alessio; Spaccarotella, Elisa; Holmes, Antony B; Arcaini, Luca; Lucioni, Marco; Tabbò, Fabrizio; Zairis, Sakellarios; Diop, Fary; Cerri, Michaela; Chiaretti, Sabina; Marasca, Roberto; Ponzoni, Maurilio; Deaglio, Silvia; Ramponi, Antonio; Tiacci, Enrico; Pasqualucci, Laura; Paulli, Marco; Falini, Brunangelo; Inghirami, Giorgio; Bertoni, Francesco; Foà, Robin; Rabadan, Raul; Gaidano, Gianluca; Rossi, Davide


    Nodal marginal zone lymphoma (NMZL) is a rare, indolent B-cell tumor that is distinguished from splenic marginal zone lymphoma (SMZL) by the different pattern of dissemination. NMZL still lacks distinct markers and remains orphan of specific cancer gene lesions. By combining whole-exome sequencing, targeted sequencing of tumor-related genes, whole-transcriptome sequencing, and high-resolution single nucleotide polymorphism array analysis, we aimed at disclosing the pathways that are molecularly deregulated in NMZL and we compare the molecular profile of NMZL with that of SMZL. These analyses identified a distinctive pattern of nonsilent somatic lesions in NMZL. In 35 NMZL patients, 41 genes were found recurrently affected in ≥3 (9%) cases, including highly prevalent molecular lesions of MLL2 (also known as KMT2D; 34%), PTPRD (20%), NOTCH2 (20%), and KLF2 (17%). Mutations of PTPRD, a receptor-type protein tyrosine phosphatase regulating cell growth, were enriched in NMZL across mature B-cell tumors, functionally caused the loss of the phosphatase activity of PTPRD, and were associated with cell-cycle transcriptional program deregulation and increased proliferation index in NMZL. Although NMZL shared with SMZL a common mutation profile, NMZL harbored PTPRD lesions that were otherwise absent in SMZL. Collectively, these findings provide new insights into the genetics of NMZL, identify PTPRD lesions as a novel marker for this lymphoma across mature B-cell tumors, and support the distinction of NMZL as an independent clinicopathologic entity within the current lymphoma classification. © 2016 by The American Society of Hematology.

  12. Asymmetry of high-velocity lower crust on the South Atlantic rifted margins and implications for the interplay of magmatism and tectonics in continental break-up

    Directory of Open Access Journals (Sweden)

    K. Becker


    Full Text Available High-velocity lower crust (HVLC and seaward dipping reflector sequences (SDRs are typical features of volcanic rifted margins. However, the nature and origin of HVLC is under discussion. Here we provide a comprehensive analysis of deep crustal structures in the southern segment of the South Atlantic and an assessment of HVLC along the margins. Two new seismic refraction lines off South America fill a gap in the data coverage and together with five existing velocity models allow a detailed investigation of the lower crustal properties on both margins. An important finding is the major asymmetry in volumes of HVLC on the conjugate margins. The seismic refraction lines across the South African margin reveal four times larger cross sectional areas of HVLC than at the South American margin, a finding that is in sharp contrast to the distribution of the flood basalts in the Paraná-Etendeka Large Igneous Provinces (LIP. Also, the position of the HVLC with respect to the seaward dipping reflector sequences varies consistently along both margins. Close to the Falkland-Agulhas Fracture Zone a small body of HVLC is not accompanied by seaward dipping reflectors. In the central portion of both margins, the HVLC is below the inner seaward dipping reflector wedges while in the northern area, closer to the Rio Grande Rise/Walvis Ridge, large volumes of HVLC extend far seawards of the inner seaward dipping reflectors. This challenges the concept of a simple extrusive/intrusive relationship between seaward dipping reflector sequences and HVLC, and it provides evidence for formation of the HVLC at different times during the rifting and break-up process. We suggest that the drastically different HVLC volumes are caused by asymmetric rifting in a simple shear dominated extension.

  13. Individualized Nonadaptive and Online-Adaptive Intensity-Modulated Radiotherapy Treatment Strategies for Cervical Cancer Patients Based on Pretreatment Acquired Variable Bladder Filling Computed Tomography Scans

    Energy Technology Data Exchange (ETDEWEB)

    Bondar, M.L., E-mail: [Department of Radiation Oncology, Erasmus-MC Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Hoogeman, M.S.; Mens, J.W.; Quint, S. [Department of Radiation Oncology, Erasmus-MC Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Ahmad, R. [Department of Radiation Oncology, Erasmus-MC Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Programme of Diagnostic Imaging and Radiotherapy, University Kebangsaan Malaysia (Malaysia); Dhawtal, G.; Heijmen, B.J. [Department of Radiation Oncology, Erasmus-MC Daniel den Hoed Cancer Center, Rotterdam (Netherlands)


    Purpose: To design and evaluate individualized nonadaptive and online-adaptive strategies based on a pretreatment established motion model for the highly deformable target volume in cervical cancer patients. Methods and Materials: For 14 patients, nine to ten variable bladder filling computed tomography (CT) scans were acquired at pretreatment and after 40 Gy. Individualized model-based internal target volumes (mbITVs) accounting for the cervix and uterus motion due to bladder volume changes were generated by using a motion-model constructed from two pretreatment CT scans (full and empty bladder). Two individualized strategies were designed: a nonadaptive strategy, using an mbITV accounting for the full-range of bladder volume changes throughout the treatment; and an online-adaptive strategy, using mbITVs of bladder volume subranges to construct a library of plans. The latter adapts the treatment online by selecting the plan-of-the-day from the library based on the measured bladder volume. The individualized strategies were evaluated by the seven to eight CT scans not used for mbITVs construction, and compared with a population-based approach. Geometric uniform margins around planning cervix-uterus and mbITVs were determined to ensure adequate coverage. For each strategy, the percentage of the cervix-uterus, bladder, and rectum volumes inside the planning target volume (PTV), and the clinical target volume (CTV)-to-PTV volume (volume difference between PTV and CTV) were calculated. Results: The margin for the population-based approach was 38 mm and for the individualized strategies was 7 to 10 mm. Compared with the population-based approach, the individualized nonadaptive strategy decreased the CTV-to-PTV volume by 48% {+-} 6% and the percentage of bladder and rectum inside the PTV by 5% to 45% and 26% to 74% (p < 0.001), respectively. Replacing the individualized nonadaptive strategy by an online-adaptive, two-plan library further decreased the percentage of

  14. Analysis of System Margins on Missions Utilizing Solar Electric Propulsion (United States)

    Oh, David Y.; Landau, Damon; Randolph, Thomas; Timmerman, Paul; Chase, James; Sims, Jon; Kowalkowski, Theresa


    NASA's Jet Propulsion Laboratory has conducted a study focused on the analysis of appropriate margins for deep space missions using solar electric propulsion (SEP). The purpose of this study is to understand the links between disparate system margins (power, mass, thermal, etc.) and their impact on overall mission performance and robustness. It is determined that the various sources of uncertainty and risk associated with electric propulsion mission design can be summarized into three relatively independent parameters 1) EP Power Margin, 2) Propellant Margin and 3) Duty Cycle Margin. The overall relationship between these parameters and other major sources of uncertainty is presented. A detailed trajectory analysis is conducted to examine the impact that various assumptions related to power, duty cycle, destination, and thruster performance including missed thrust periods have on overall performance. Recommendations are presented for system margins for deep space missions utilizing solar electric propulsion.

  15. Margin Requirements and Portfolio Optimization: A Geometric Approach


    Sheng Guo


    Using geometric illustrations, we investigate what implications of portfolio optimization in equilibrium can be generated by the simple mean-variance framework, under margin borrowing restrictions. First, we investigate the case of uniform marginability on all risky assets. It is shown that changing from unlimited borrowing to margin borrowing shifts the market portfolio to a riskier combination, accompanied by a higher risk premium and a lower price of risk. With the linear risk-return prefe...

  16. Marginal pricing of transmission services. An analysis of cost recovery

    Energy Technology Data Exchange (ETDEWEB)

    Perez-Arriaga, I.J.., Rubio, F.J. [Instituto de Investigacion Technologica, Universidad Pontificia Comillas, Madrid (Spain); Puerta, J.F.; Arceluz, J.; Marin, J. [Unidad de Planificacion Estrategica, Iberdrola, Madrid (Spain)


    The authors present an in-depth analysis of network revenues that are computed with marginal pricing, and investigate the reasons why marginal prices in actual power systems fail to recover total incurred network costs. The major causes of the failure are identified and illustrated with numerical examples. The paper analyzes the regulatory implications of marginal network pricing in the context of competitive electricity markets and provides suggestions for the meaningful allocation of network costs among users. 5 figs., 9 tabs., 8 refs.

  17. Convex games, clan games, and their marginal games


    Branzei , Rodica; Dimitrov, Dinko; Tijs, Stef


    We provide characterizations of convex games and total clan games by using properties of their corresponding marginal games. As it turns out, a cooperative game is convex if and only if all its marginal games are superadditive, and a monotonic game satisfying the veto player property with respect to the members of a coalition C is a total clan game (with clan C) if and only if all its C-based marginal games are subadditive.

  18. Ex vivo ultrasound control of resection margins during partial nephrectomy. (United States)

    Doerfler, Arnaud; Cerantola, Yannick; Meuwly, Jean-Yves; Lhermitte, Benoît; Bensadoun, Henri; Jichlinski, Patrice


    Surgery remains the treatment of choice for localized renal neoplasms. While radical nephrectomy was long considered the gold standard, partial nephrectomy has equivalent oncological results for small tumors. The role of negative surgical margins continues to be debated. Intraoperative frozen section analysis is expensive and time-consuming. We assessed the feasibility of intraoperative ex vivo ultrasound of resection margins in patients undergoing partial nephrectomy and its correlation with margin status on definitive pathological evaluation. A study was done at 2 institutions from February 2008 to March 2011. Patients undergoing partial nephrectomy for T1-T2 renal tumors were included in analysis. Partial nephrectomy was done by a standardized minimal healthy tissue margin technique. After resection the specimen was kept in saline and tumor margin status was immediately determined by ex vivo ultrasound. Sequential images were obtained to evaluate the whole tumor pseudocapsule. Results were compared with margin status on definitive pathological evaluation. A total of 19 men and 14 women with a mean ± SD age of 62 ± 11 years were included in analysis. Intraoperative ex vivo ultrasound revealed negative surgical margins in 30 cases and positive margins in 2 while it could not be done in 1. Final pathological results revealed negative margins in all except 1 case. Ultrasound sensitivity and specificity were 100% and 97%, respectively. Median ultrasound duration was 1 minute. Mean tumor and margin size was 3.6 ± 2.2 cm and 1.5 ± 0.7 mm, respectively. Intraoperative ex vivo ultrasound of resection margins in patients undergoing partial nephrectomy is feasible and efficient. Large sample studies are needed to confirm its promising accuracy to determine margin status. Copyright © 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  19. Boost invariant marginally trapped surfaces in Minkowski 4-space

    Energy Technology Data Exchange (ETDEWEB)

    Haesen, S [Department of Mathematics, Katholieke Universiteit Leuven, Celestijnenlaan 200B, 3001 Heverlee (Belgium); Ortega, M [Departamento de GeometrIa y TopologIa, Universidad de Granada, 18071 Granada (Spain)


    The extremal and partly marginally trapped surfaces in the Minkowski 4-space, which are invariant under the group of boost isometries, are classified. Moreover, it is shown that there do not exist extremal surfaces of this kind with constant Gaussian curvature. A procedure is given in order to construct a partly marginally trapped surface by gluing two marginally trapped surfaces which are invariant under the group of boost isometries. As an application, a proper star-surface is constructed.

  20. Intrafraction Prostate Translations and Rotations During Hypofractionated Robotic Radiation Surgery: Dosimetric Impact of Correction Strategies and Margins

    Energy Technology Data Exchange (ETDEWEB)

    Water, Steven van de, E-mail: [Erasmus MC Cancer Institute, Department of Radiation Oncology, Rotterdam (Netherlands); Valli, Lorella [Erasmus MC Cancer Institute, Department of Radiation Oncology, Rotterdam (Netherlands); Alma Mater Studiorum, Department of Physics and Astronomy, Bologna University, Bologna (Italy); Aluwini, Shafak [Erasmus MC Cancer Institute, Department of Radiation Oncology, Rotterdam (Netherlands); Lanconelli, Nico [Alma Mater Studiorum, Department of Physics and Astronomy, Bologna University, Bologna (Italy); Heijmen, Ben; Hoogeman, Mischa [Erasmus MC Cancer Institute, Department of Radiation Oncology, Rotterdam (Netherlands)


    Purpose: To investigate the dosimetric impact of intrafraction prostate motion and the effect of robot correction strategies for hypofractionated CyberKnife treatments with a simultaneously integrated boost. Methods and Materials: A total of 548 real-time prostate motion tracks from 17 patients were available for dosimetric simulations of CyberKnife treatments, in which various correction strategies were included. Fixed time intervals between imaging/correction (15, 60, 180, and 360 seconds) were simulated, as well as adaptive timing (ie, the time interval reduced from 60 to 15 seconds in case prostate motion exceeded 3 mm or 2° in consecutive images). The simulated extent of robot corrections was also varied: no corrections, translational corrections only, and translational corrections combined with rotational corrections up to 5°, 10°, and perfect rotational correction. The correction strategies were evaluated for treatment plans with a 0-mm or 3-mm margin around the clinical target volume (CTV). We recorded CTV coverage (V{sub 100%}) and dose-volume parameters of the peripheral zone (boost), rectum, bladder, and urethra. Results: Planned dose parameters were increasingly preserved with larger extents of robot corrections. A time interval between corrections of 60 to 180 seconds provided optimal preservation of CTV coverage. To achieve 98% CTV coverage in 98% of the treatments, translational and rotational corrections up to 10° were required for the 0-mm margin plans, whereas translational and rotational corrections up to 5° were required for the 3-mm margin plans. Rectum and bladder were spared considerably better in the 0-mm margin plans. Adaptive timing did not improve delivered dose. Conclusions: Intrafraction prostate motion substantially affected the delivered dose but was compensated for effectively by robot corrections using a time interval of 60 to 180 seconds. A 0-mm margin required larger extents of additional rotational corrections than a 3

  1. Extracranial image-guided stereotactic; Stereotaxie extracranienne guidee par l'image

    Energy Technology Data Exchange (ETDEWEB)

    Ailleres, N.; Fenoglietto, P.; Boisselier, P.; Santoro, L.; Idri, K.; Simeon, S.; Azria, D.; Dubois, J.B. [CRLCC, Val d' Aurelle-Paul-Lamarque, Dept. de Radiotherapie Oncologique, 34 - Montpellier (France)


    The use of three-dimensional imaging board associated to dynamic computed tomography allows to reduce the patients positioning margins and to make sure that the target stays in the planned treatment volume (P.T.V.) during the different sessions. (N.C.)

  2. Understanding the heterogeneity in volume overload and fluid distribution in decompensated heart failure is key to optimal volume management: role for blood volume quantitation. (United States)

    Miller, Wayne L; Mullan, Brian P


    This study sought to quantitate total blood volume (TBV) in patients hospitalized for decompensated chronic heart failure (DCHF) and to determine the extent of volume overload, and the magnitude and distribution of blood volume and body water changes following diuretic therapy. The accurate assessment and management of volume overload in patients with DCHF remains problematic. TBV was measured by a radiolabeled-albumin dilution technique with intravascular volume, pre-to-post-diuretic therapy, evaluated at hospital admission and at discharge. Change in body weight in relation to quantitated TBV was used to determine interstitial volume contribution to total fluid loss. Twenty-six patients were prospectively evaluated. Two patients had normal TBV at admission. Twenty-four patients were hypervolemic with TBV (7.4 ± 1.6 liters) increased by +39 ± 22% (range, +9.5% to +107%) above the expected normal volume. With diuresis, TBV decreased marginally (+30 ± 16%). Body weight declined by 6.9 ± 5.2 kg, and fluid intake/fluid output was a net negative 8.4 ± 5.2 liters. Interstitial compartment fluid loss was calculated at 6.2 ± 4.0 liters, accounting for 85 ± 15% of the total fluid reduction. TBV analysis demonstrated a wide range in the extent of intravascular overload. Dismissal measurements revealed marginally reduced intravascular volume post-diuretic therapy despite large reductions in body weight. Mobilization of interstitial fluid to the intravascular compartment with diuresis accounted for this disparity. Intravascular volume, however, remained increased at dismissal. The extent, composition, and distribution of volume overload are highly variable in DCHF, and this variability needs to be taken into account in the approach to individualized therapy. TBV quantitation, particularly serial measurements, can facilitate informed volume management with respect to a goal of treating to euvolemia. Copyright © 2014 American College of Cardiology Foundation. Published

  3. Marginal pricing of transmission services: An analysis of cost recovery

    Energy Technology Data Exchange (ETDEWEB)

    Perez-Arriaga, I.J.; Rubio, F.J. [Univ. Pontificia Comillas, Madrid (Spain); Puerta, J.F.; Arceluz, J.; Marin, J. [IBERDROLA, Bilbao (Spain). Unidad de Planificacion Estrategica


    This paper presents an in-depth analysis of network revenues computed with marginal pricing, and in particular it investigates the reasons why marginal prices fail to recover the total incurred network costs in actual power systems. The basic theoretical results are presented and the major causes of the mismatch between network costs and marginal revenues are identified and illustrated with numerical examples, some tutorial and others of realistic size. The regulatory implications of marginal network pricing in the context of competitive electricity markets are analyzed, and suggestions are provided for the meaningful allocation of the costs of the network among its users.

  4. The many ways to be marginal in a group. (United States)

    Ellemers, Naomi; Jetten, Jolanda


    Previous theory and research primarily address marginal group members on the path to achieve core membership status. The authors argue that these only represent one form of marginality and that there are many other ways to be marginal within the group. The authors develop a dynamic model in which marginality is conceptualized as resulting from group and individual negotiation about inclusion (the Marginality as Resulting From Group and Individual Negotiation About Inclusion [MARGINI] model), and where individual and group inclusion goals can converge (resulting in relatively stable forms of marginality) or diverge (resulting in less stable forms of marginality). When the marginal position is unstable, individuals can either be motivated to move toward or move further away from the group, and such changing inclusion goals are associated with different emotions and behaviors. The authors argue that one needs to understand the interplay between individual and group inclusion goals to predict and explain the full complexity and diversity of the behavior of marginal group members.

  5. Maximum-entropy distributions of correlated variables with prespecified marginals. (United States)

    Larralde, Hernán


    The problem of determining the joint probability distributions for correlated random variables with prespecified marginals is considered. When the joint distribution satisfying all the required conditions is not unique, the "most unbiased" choice corresponds to the distribution of maximum entropy. The calculation of the maximum-entropy distribution requires the solution of rather complicated nonlinear coupled integral equations, exact solutions to which are obtained for the case of Gaussian marginals; otherwise, the solution can be expressed as a perturbation around the product of the marginals if the marginal moments exist.

  6. Comparative biogeochemistry-ecosystem-human interactions on dynamic continental margins (United States)

    Levin, Lisa A.; Liu, Kon-Kee; Emeis, Kay-Christian; Breitburg, Denise L.; Cloern, James; Deutsch, Curtis; Giani, Michele; Goffart, Anne; Hofmann, Eileen E.; Lachkar, Zouhair; Limburg, Karin; Liu, Su-Mei; Montes, Enrique; Naqvi, Wajih; Ragueneau, Olivier; Rabouille, Christophe; Sarkar, Santosh Kumar; Swaney, Dennis P.; Wassman, Paul; Wishner, Karen F.


    The ocean’s continental margins face strong and rapid change, forced by a combination of direct human activity, anthropogenic CO2-induced climate change, and natural variability. Stimulated by discussions in Goa, India at the IMBER IMBIZO III, we (1) provide an overview of the drivers of biogeochemical variation and change on margins, (2) compare temporal trends in hydrographic and biogeochemical data across different margins (3) review ecosystem responses to these changes, (4) highlight the importance of margin time series for detecting and attributing change and (5) examine societal responses to changing margin biogeochemistry and ecosystems. We synthesize information over a wide range of margin settings in order to identify the commonalities and distinctions among continental margin ecosystems. Key drivers of biogeochemical variation include long-term climate cycles, CO2-induced warming, acidification, and deoxygenation, as well as sea level rise, eutrophication, hydrologic and water cycle alteration, changing land use, fishing, and species invasion. Ecosystem responses are complex and impact major margin services including primary production, fisheries production, nutrient cycling, shoreline protection, chemical buffering, and biodiversity. Despite regional differences, the societal consequences of these changes are unarguably large and mandate coherent actions to reduce, mitigate and adapt to multiple stressors on continental margins.

  7. Marginal distortion of thermally incompatible metal ceramic crowns with overextended margins. (United States)

    Nakamura, Y; Anusavice, K J


    The present study tested the hypothesis that metal ceramic crowns with a varying axial height are more susceptible to marginal distortion during mechanical and thermal processing treatments than crowns with a uniform axial height. Copings of Pd-Cu-Ga alloy with buccal margin extensions of 0, 1.5, and 3.0 mm were prepared. Oxidized copings were veneered with experimental opaque porcelain with a mean thermal contraction coefficient (25 degrees C to 500 degrees C) that was either 2.1 ppm/degree C below (delta alpha = +2.1 ppm/degree C) or 0.1 ppm/degree C above (delta alpha = -0.1 ppm/degree C) that of the alloy. Nine groups of six specimens each were prepared for analysis. Eighteen copings from these 54 specimens were used as porcelain-free controls. All specimens were subjected to a 10-step procedure including grinding, oxidation, firing of four opaque porcelain layers (O1: 0.15 mm; O2: 0.15 mm; O3: 0.5 mm; O4: 0.5 mm), glazing, abrasive blasting for 15 seconds, removal of ceramic by dissolution in hydrogen fluoride, and a postannealing treatment. The control specimens were also subjected to this procedure with the exception of the firing of four layers of porcelain, which were not applied. Marginal gap width was determined using a measuring microscope at a magnification of 30x. Analysis of variance revealed a significant difference in mean gap width as a function of axial length. The largest gap change was associated with a 3.0-mm buccal extension and the negative mismatch condition (delta alpha < 0). Marginal distortion of crowns decreases as the axial length becomes more uniform. Analysis of crown distortion based on differences in the mean contraction coefficients of metal and porcelain alone is not recommended because it ignores the effects of metal grinding, metal sandblasting, and transient stress.

  8. Seaward dipping reflectors along the SW continental margin of India: Evidence for volcanic passive margin

    Indian Academy of Sciences (India)

    K K Ajay; A K Chaubey; K S Krishna; D Gopala Rao; D Sar


    Multi-channel seismic reflection profiles across the southwest continental margin of India (SWCMI) show presence of westerly dipping seismic reflectors beneath sedimentary strata along the western flank of the Laccadive Ridge –northernmost part of the Chagos –Laccadive Ridge system. Velocity structure, seismic character, 2D gravity model and geographic locations of the dipping reflectors suggest that these reflectors are volcanic in origin, which are interpreted as Seaward Dipping Reflectors (SDRs). The SDRs; 15 to 27 km wide overlain by ∼1 km thick sediment; are observed at three locations and characterized by stack of laterally continuous, divergent and off-lapping reflectors. Occurrence of SDRs along western flank of the Laccadive Ridge adjacent to oceanic crust of the Arabian Basin and 2D crustal model deduced from free-air gravity anomaly suggest that they are genetically related to incipient volcanism during separation of Madagascar from India. We suggest that (i)SWCMI is a volcanic passive margin developed during India –Madagascar breakup in the Late Cretaceous, and (ii)continent –ocean transition lies at western margin of the Laccadive Ridge, west of feather edge of the SDRs. Occurrence of SDRs on western flank of the Laccadive Ridge and inferred zone of transition from continent to ocean further suggest continental nature of crust of the Laccadive Ridge.

  9. Shielding in whole brain irradiation in the multileaf collimator era: Dosimetric evaluation of coverage using SFOP guidelines against in-house guidelines

    Directory of Open Access Journals (Sweden)

    Patil Vijay


    Full Text Available Aim : Compare the planning target volume (PTV coverage in three different shielding techniques in cranial irradiation. Settings and Design : Tertiary care center, prospective study. Materials and Methods : The whole brain and meninges were contoured in ten planning CT scans, and expanded by 5 mm for the PTV. Shielding was designed using the French Society of Pediatric Oncology (SFOP guidelines (SFOP plan, in-house recommendation (with 1 cm margin from the orbital roof and sphenoid wing on a igitally Reconstructed Radiograph (DRR and a third plan was generated using a 3D conformal radiation technique (3DCRT. The coverage of the PTV was noted using the isodose covering 95% of the PTV(D95, minimum dose within the PTV(D min , and maximum dose within the PTV(D max . The location of PTV not covered by the 95% isodose curve was noted. The median dose and maximum dose (D max to both eyes and maximum dose D max for the lens were noted. Statistical Analysis : General linear model method repeated the measure of analysis of variance test (ANOVA. Results : PTV coverage was significantly poorer in the SFOP and in-house plans as compared to 3DCRT plan (P=0.04. Median volume of PTV not covered by 95% isodose curve was 4.18 cc, 1.01 cc, and 0 cc in SFOP, in-house, and 3DCRT plan, respectively. Conclusions : In the absence of volumetric planning techniques, SFOP guidelines lead to inadequate coverage and the in-house method is recommended.

  10. Heat flow in northwest Pacific marginal seas

    Institute of Scientific and Technical Information of China (English)

    JIANG Lili; LI Guanbao; LI Naisheng


    Heat flow studies in Northwest Pacific marginal seas has a more than 40 years history with more than 4000 heat flow values obtained. The regional average value is 80.4 mW/m2, which is lower than the world's 87 mW/m2, but higher than those of the Eurasia continent and the Pacific Ocean. This reflects the regional crust property in the area. The studies on distribution of the heat flow and contour pattern of heat flow in 1°×1°and 2°×2°scales in Northwest Pacific marginal seas revealed that the most high heat flow anomalies in the area were found along back-arc basins and island arc in an obviously northeasterly track. Exceptions are the Komandoskaya Basin (KMB), the Izu-Bonin Trough (IBT) and the Mariana Trough (MT), which extend in northwest. The contours of low heat flow marked the boundaries of the continent and the ocean. The present heat flow values reflect the imprint of the last thermal event and relate closely to tectonic activity. The high heat flow gradient areas have high frequency of earthquake. Therefore, the area of faulting controlled the pattern of the heat flow anomalies. Heat flow gradient in 135°direction indicated a major lithosphere transformation oceanward resulting from movement of the earth's material. In this paper, we described patterns of heat flow distribution in the Northwest Pacific, heat flow value changes in horizontal and vertical directions, combining the studies of Shi (1997) on the landforms of the island arcs in east Asia and plate movement, and the results of Shi and Zhang (1998) on heat simulation of subduction of active ocean mountain and the activity of islands arc. A preliminary model of geodynamics in the Northwest Pacific and its adjacent area was put forward. There is a great lateral heat flow gradient on the surface of the mantle between ocean and continent, which indicates that the materials in asthenosphere move from continent to ocean causing movement of the crust.

  11. WE-B-304-02: Treatment Planning Evaluation and Optimization Should Be Biologically and Not Dose/volume Based

    Energy Technology Data Exchange (ETDEWEB)

    Deasy, J. [Memorial Sloan Kettering Cancer Center, New York, NY (United States)


    The ultimate goal of radiotherapy treatment planning is to find a treatment that will yield a high tumor control probability (TCP) with an acceptable normal tissue complication probability (NTCP). Yet most treatment planning today is not based upon optimization of TCPs and NTCPs, but rather upon meeting physical dose and volume constraints defined by the planner. It has been suggested that treatment planning evaluation and optimization would be more effective if they were biologically and not dose/volume based, and this is the claim debated in this month’s Point/Counterpoint. After a brief overview of biologically and DVH based treatment planning by the Moderator Colin Orton, Joseph Deasy (for biological planning) and Charles Mayo (against biological planning) will begin the debate. Some of the arguments in support of biological planning include: this will result in more effective dose distributions for many patients DVH-based measures of plan quality are known to have little predictive value there is little evidence that either D95 or D98 of the PTV is a good predictor of tumor control sufficient validated outcome prediction models are now becoming available and should be used to drive planning and optimization Some of the arguments against biological planning include: several decades of experience with DVH-based planning should not be discarded we do not know enough about the reliability and errors associated with biological models the radiotherapy community in general has little direct experience with side by side comparisons of DVH vs biological metrics and outcomes it is unlikely that a clinician would accept extremely cold regions in a CTV or hot regions in a PTV, despite having acceptable TCP values Learning Objectives: To understand dose/volume based treatment planning and its potential limitations To understand biological metrics such as EUD, TCP, and NTCP To understand biologically based treatment planning and its potential limitations.

  12. WE-B-304-01: Treatment Planning Evaluation and Optimization Should Be Dose/volume and Not Biologically Based

    Energy Technology Data Exchange (ETDEWEB)

    Mayo, C. [Mayo Clinic (United States)


    The ultimate goal of radiotherapy treatment planning is to find a treatment that will yield a high tumor control probability (TCP) with an acceptable normal tissue complication probability (NTCP). Yet most treatment planning today is not based upon optimization of TCPs and NTCPs, but rather upon meeting physical dose and volume constraints defined by the planner. It has been suggested that treatment planning evaluation and optimization would be more effective if they were biologically and not dose/volume based, and this is the claim debated in this month’s Point/Counterpoint. After a brief overview of biologically and DVH based treatment planning by the Moderator Colin Orton, Joseph Deasy (for biological planning) and Charles Mayo (against biological planning) will begin the debate. Some of the arguments in support of biological planning include: this will result in more effective dose distributions for many patients DVH-based measures of plan quality are known to have little predictive value there is little evidence that either D95 or D98 of the PTV is a good predictor of tumor control sufficient validated outcome prediction models are now becoming available and should be used to drive planning and optimization Some of the arguments against biological planning include: several decades of experience with DVH-based planning should not be discarded we do not know enough about the reliability and errors associated with biological models the radiotherapy community in general has little direct experience with side by side comparisons of DVH vs biological metrics and outcomes it is unlikely that a clinician would accept extremely cold regions in a CTV or hot regions in a PTV, despite having acceptable TCP values Learning Objectives: To understand dose/volume based treatment planning and its potential limitations To understand biological metrics such as EUD, TCP, and NTCP To understand biologically based treatment planning and its potential limitations.

  13. Large volume unresectable locally advanced non-small cell lung cancer: acute toxicity and initial outcome results with rapid arc

    Directory of Open Access Journals (Sweden)

    Fogliata Antonella


    Full Text Available Abstract Background To report acute toxicity, initial outcome results and planning therapeutic parameters in radiation treatment of advanced lung cancer (stage III with volumetric modulated arcs using RapidArc (RA. Methods Twenty-four consecutive patients were treated with RA. All showed locally advanced non-small cell lung cancer with stage IIIA-IIIB and with large volumes (GTV:299 ± 175 cm3, PTV:818 ± 206 cm3. Dose prescription was 66Gy in 33 fractions to mean PTV. Delivery was performed with two partial arcs with a 6 MV photon beam. Results From a dosimetric point of view, RA allowed us to respect most planning objectives on target volumes and organs at risk. In particular: for GTV D1% = 105.6 ± 1.7%, D99% = 96.7 ± 1.8%, D5%-D95% = 6.3 ± 1.4%; contra-lateral lung mean dose resulted in 13.7 ± 3.9Gy, for spinal cord D1% = 39.5 ± 4.0Gy, for heart V45Gy = 9.0 ± 7.0Gy, for esophagus D1% = 67.4 ± 2.2Gy. Delivery time was 133 ± 7s. At three months partial remission > 50% was observed in 56% of patients. Acute toxicities at 3 months showed 91% with grade 1 and 9% with grade 2 esophageal toxicity; 18% presented grade 1 and 9% with grade 2 pneumonia; no grade 3 acute toxicity was observed. The short follow-up does not allow assessment of local control and progression free survival. Conclusions RA proved to be a safe and advantageous treatment modality for NSCLC with large volumes. Long term observation of patients is needed to assess outcome and late toxicity.

  14. Oceanography: 1998 Paris Meeting Abstracts: Coastal and Marginal Seas. Volume 11, Number 2. (United States)


    Millan (1), Joan Cleveland (2) - (1) Centra de investigacion Cientifica y Educacion , Superior de Ensenada, Apdo. MSP-45: Spatial Patterns of Plankter...Education Superior de Ensenada, Ensenada (CICESE), B.C. Mexico.Km. 107 Carr. Tijuana-Ensenada, Ensenada, B.C. Mexico; (2) Environment Division...performance vs. price barrier The SBE 39 offers superior performance and low price. Standard Features: • Extremely accurate ( + 0.002°C) and stable

  15. Avaliação da margem do PTV em tumores ginecológicos com irradiação dos gânglios lomboaórticos, que realizaram IMRT


    Barateiro, Andreia Sofia


    Mestrado em Radioterapia. Há vários anos atrás, poucos eram os físicos, que punham a possibilidade de modular a fluência do feixe e com esta conseguir um escalonamento de dose no volume alvo e ao mesmo tempo diminuir a dose nos órgãos de risco. Neoplasias do Endométrio e do Colo do Útero sujeitos a irradiação ganglionar lomboaórtica possuem através da IMRT (Intensity Modulated Radiation Therapy) a oportunidade de conseguir obter uma melhor conformação de dose ao volume alvo e deste modo mi...

  16. An Image-Guided Study of Setup Reproducibility of Postmastectomy Breast Cancer Patients Treated With Inverse-Planned Intensity Modulated Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Feng, Christine H.; Gerry, Emily; Chmura, Steven J.; Hasan, Yasmin; Al-Hallaq, Hania A., E-mail:


    Purpose: To calculate planning target volume (PTV) margins for chest wall and regional nodal targets using daily orthogonal kilovolt (kV) imaging and to study residual setup error after kV alignment using volumetric cone-beam computed tomography (CBCT). Methods and Materials: Twenty-one postmastectomy patients were treated with intensity modulated radiation therapy with 7-mm PTV margins. Population-based PTV margins were calculated from translational shifts after daily kV positioning and/or weekly CBCT data for each of 8 patients, whose surgical clips were used as surrogates for target volumes. Errors from kV and CBCT data were mathematically combined to generate PTV margins for 3 simulated alignment workflows: (1) skin marks alone; (2) weekly kV imaging; and (3) daily kV imaging. Results: The kV data from 613 treatment fractions indicated that a 7-mm uniform margin would account for 95% of daily shifts if patients were positioned using only skin marks. Total setup errors incorporating both kV and CBCT data were larger than those from kV alone, yielding PTV expansions of 7 mm anterior–posterior, 9 mm left–right, and 9 mm superior–inferior. Required PTV margins after weekly kV imaging were similar in magnitude as alignment to skin marks, but rotational adjustments of patients were required in 32% ± 17% of treatments. These rotations would have remained uncorrected without the use of daily kV imaging. Despite the use of daily kV imaging, CBCT data taken at the treatment position indicate that an anisotropic PTV margin of 6 mm anterior–posterior, 4 mm left–right, and 8 mm superior–inferior must be retained to account for residual errors. Conclusions: Cone-beam CT provides additional information on 3-dimensional reproducibility of treatment setup for chest wall targets. Three-dimensional data indicate that a uniform 7-mm PTV margin is insufficient in the absence of daily IGRT. Interfraction movement is greater than suggested by 2-dimensional

  17. Dosimetry analyses comparing high-dose-rate brachytherapy, administered as monotherapy for localized prostate cancer, with stereotactic body radiation therapy simulated using CyberKnife. (United States)

    Fukuda, Shoichi; Seo, Yuji; Shiomi, Hiroya; Yamada, Yuji; Ogata, Toshiyuki; Morimoto, Masahiro; Konishi, Koji; Yoshioka, Yasuo; Ogawa, Kazuhiko


    The purpose of this study was to perform dosimetry analyses comparing high-dose-rate brachytherapy (HDR-BT) with simulated stereotactic body radiotherapy (SBRT). We selected six consecutive patients treated with HDR-BT monotherapy in 2010, and a CyberKnife SBRT plan was simulated for each patient using computed tomography images and the contouring set used in the HDR-BT plan for the actual treatment, but adding appropriate planning target volume (PTV) margins for SBRT. Then, dosimetric profiles for PTVs of the rectum, bladder and urethra were compared between the two modalities. The SBRT plan was more homogenous and provided lower dose concentration but better coverage for the PTV. The maximum doses in the rectum were higher in the HDR-BT plans. However, the HDR-BT plan provided a sharper dose fall-off around the PTV, resulting in a significant and considerable difference in volume sparing of the rectum with the appropriate PTV margins added for SBRT. While the rectum D5cm(3) for HDR-BT and SBRT was 30.7 and 38.3 Gy (P urethra. These results suggest that SBRT as an alternative to HDR-BT in hypofractionated radiotherapy for prostate cancer might have an advantage for bladder and urethra dose sparing, but for the rectum only when proper PTV margins for SBRT are adopted.

  18. Marginal pulmonary function is associated with poor short- and long-term outcomes in lung cancer surgery (United States)

    Ozeki, Naoki; Kawaguchi, Koji; Okasaka, Toshiki; Fukui, Takayuki; Fukumoto, Koichi; Nakamura, Shota; Hakiri, Shuhei; Yokoi, Kohei


    ABSTRACT We sought to determine the short- and long-term prognoses among ‘marginal-risk’ non-small cell lung cancer patients who have a predicted postoperative- (ppo) forced expiratory volume in the first second (FEV1) of 30–60% and/or a ppo-diffusing capacity of the lung for carbon monoxide (DLCO) of 30–60%. The present study included 73 ‘marginal-risk’ and 318 ‘normal-risk’ patients who underwent anatomical resection for clinical stage I lung cancer between 2008 and 2012. The rates of postoperative morbidity, prolonged hospital stay, and overall survival were assessed. Postoperative morbidity occurred in 35 (48%) ‘marginal-risk’ patients and 66 (21%) ‘normal-risk’ patients, and 17 (23%) ‘marginal-risk’ patients and 20 (6%) ‘normal-risk’ patients required a prolonged hospital stay. The three- and five-year survival rates were 79% and 64% in the ‘marginal-risk’ patients and 93% and 87% in the ‘normal-risk’ patients, respectively. A ‘marginal-risk’ status was a significant factor in the prediction of postoperative morbidity (odds ratio [OR] 2.97, p < 0.001), the rate of prolonged hospital stay (OR 3.83, p < 0.001), and overall survival (hazard ratio 2.07, p = 0.028). In conclusion, ‘Marginal-risk’ patients, who are assessed based on ppo-values, comprise a subgroup of patients with poorer short- and long-term postoperative outcomes.

  19. The giant Ruatoria debris avalanche on the northern Hikurangi margin, New Zealand: Result of oblique seamount subduction (United States)

    Collot, Jean-Yves; Lewis, Keith; Lamarche, Geoffroy; Lallemand, Serge


    Despite convergent margins being unstable systems, most reports of huge submarine slope failure have come from oceanic volcanoes and passive margins. Swath bathymetry and seismic profiles of the northern Hikurangi subduction system, New Zealand, show a tapering 65-30 km wide by 65 km deep margin indentation, with a giant, 3150±630 km3, blocky, debris avalanche deposit projecting 40 km out across horizontal trench fill, and a debris flow deposit projecting over 100 km. Slide blocks are well-bedded, up to 18 km across and 1.2 km high, the largest being at the avalanche deposit's leading edge. Samples dredged from them are mainly Miocene shelf calc-mudstones similar to those outcropping around the indentation. Cores from cover beds suggest that failure occurred ˜170±40 ka, possibly synchronously with a major extension collapse in the upper indentation. However, the northern part of the indentation is much older. The steep, straight northern wall is close to the direction of plate convergence and probably formed around 2.0-0.16 Ma as a large seamount subducted, leaving in its wake a deep groove obliquely across the margin and an unstable triangle of fractured rock in the 60° angle between groove and oversteepened margin front. The triangle collapsed as a blocky avalanche, leaving a scalloped southern wall and probably causing a large tsunami. Tentative calculations of compacted volumes suggest that the indentation is over 600 km3 larger than the avalanche, supporting a two-stage origin that includes subduction erosion. Since failure, convergence has carried the deposits ˜9 km back toward the margin, causing internal compression. The eventual subduction/accretion of the Ruatoria avalanche explains the scarcity of such features on active margins and perhaps the nature of olistostromes in fold belts.

  20. Treatment of the positive surgical margin following radical prostatectomy

    Institute of Scientific and Technical Information of China (English)


    Objective With increased incidence of prostate cancer and an increased number of patients undergoing radical prostatectomy in China,it will be necessary to elaborate the diagnosis,clinical significance and treatment of patients whose tumors have positive surgical margins following radical prostatectomy.Data sources Positive surgical margin,prostate cancer and radical prostatectomy were used as subject words and the medical literature in recent decades was searched using the PubMed database and the results are summarized.Study selection Using positive surgical margin,prostate cancer and radical prostatectomy as subject words the PubMed medical database produced 275 papers of pertinent literature.By further screening 28 papers were selected and they represent relatively large-scale clinical randomized and controlled clinical trials.Results A pertinent literature of 275 papers was identified and 28 papers on large clinical studies were obtained.Analysis of results indicated that the positive rate of surgical margin after radical prostatectomy is 20%-40%,and although most patients with positive surgical margins are stable for a considerable period,the data available now suggested that the presence of a positive surgical margin will have an impact on the patient's prognosis.The risk factors of positive surgical margin include preoperative prostate specific antigen level,Gleason's score and pelvic lymph node metastasis.The most common site with positive surgical margin is in apical areas of the prostate;therefore surgical technique is also a factor resulting in positive surgical margins.From data available now it appears that as long as the surgical technique is skilled,different surgical modes do not affect the rate of surgical margin.Adjuvant radiotherapy is mainly used to treat patients with positive surgical margin after radical prostatectomy,but combination with androgen deprivation therapy may increase the curative effect.Conclusion The current data indicated that

  1. Seismic margins and calibration of piping systems

    Energy Technology Data Exchange (ETDEWEB)

    Shieh, L.C.; Tsai, N.C.; Yang, M.S.; Wong, W.L.


    The Seismic Safety Margins Research Program (SSMRP) is a US Nuclear Regulatory Commission-funded, multiyear program conducted by Lawrence Livermore National Laboratory (LLNL). Its objective is to develop a complete, fully coupled analysis procedure for estimating the risk of earthquake-induced radioactive release from a commercial nuclear power plant and to determine major contributors to the state-of-the-art seismic and systems analysis process and explicitly includes the uncertainties in such a process. The results will be used to improve seismic licensing requirements for nuclear power plants. In Phase I of SSMRP, the overall seismic risk assessment methodology was developed and assembled. The application of this methodology to the seismic PRA (Probabilistic Risk Assessment) at the Zion Nuclear Power Plant has been documented. This report documents the method deriving response factors. The response factors, which relate design calculated responses to best estimate values, were used in the seismic response determination of piping systems for a simplified seismic probablistic risk assessment. 13 references, 31 figures, 25 tables.

  2. Salam: Of Dislocation, Marginality and Flexibility

    Directory of Open Access Journals (Sweden)

    Efenita M. Taqueban


    Full Text Available This paper reconstructs the life stories of residents of SalamCompound. The compound serves as entry point for many Muslim migrants who leave the southern Philippines. Salam is both a refuge and a halfway point. A sense of dislocation permeates the stories. Dislocation begins with the movement away from a homeland that is familiar and defining of identity. The dislocation is, in a sense, an escape, a desperate project to avoid armed conflict in the southern Philippines or a desperate enterprise in search of work.Salam is a halfway point for transients prospecting for overseas work, the staging area for a global labor exodus. The sense of dislocation is not unlike locating oneself in the margins, portrayed in the residents’ negotiated identitiesand spaces, constantly challenged, implicitly regulated. Dislocation is also depicted as flexibility, portrayed by the residents making do and their everyday creative resistance and struggle in new locations in the city. Gathered throughethnographic method, the stories offer a glimpse into the lives of the residents of the compound, how they negotiate around social constructions of identities — resisting and accommodating internal and external forces that impinge ontheir lives, revealing a rich and poignant tapestry of family relations, community ironies and an ever-impinging world beyond its walls.

  3. Vertical tectonics at an active continental margin (United States)

    Houlié, N.; Stern, T. A.


    Direct observations of vertical movements of the earth's surface are now possible with space-based GPS networks, and have applications to resources, hazards and tectonics. Here we present data on vertical movements of the Earth's surface in New Zealand, computed from the processing of GPS data collected between 2000 and 2015 by 189 permanent GPS stations. We map the geographical variation in vertical rates and show how these variations are explicable within a tectonic framework of subduction, volcanic activity and slow slip earthquakes. Subsidence of >3 mm/yr is observed along southeastern North Island and is interpreted to be due to the locked segment of the Hikurangi subduction zone. Uplift of 1-3 mm/yr further north along the margin of the eastern North Island is interpreted as being due to the plate interface being unlocked and underplating of sediment on the subduction thrust. The Volcanic Plateau of the central North Island is being uplifted at about 1 mm/yr, which can be explained by basaltic melts being injected in the active mantle-wedge at a rate of ∼6 mm/yr. Within the Central Volcanic Region there is a 250 km2 area that subsided between 2005 and 2012 at a rate of up to 14 mm/yr. Time series from the stations located within and near the zone of subsidence show a strong link between subsidence, adjacent uplift and local earthquake swarms.

  4. A multi-class large margin classifier

    Institute of Scientific and Technical Information of China (English)

    Liang TANG; Qi XUAN; Rong XIONG; Tie-jun WU; Jian CHU


    Currently there are two approaches for a multi-class support vector classifier (SVC). One is to construct and combine several binary classifiers while the other is to directly consider all classes of data in one optimization formulation. For a K-class problem (K>2), the first approach has to construct at least K classifiers, and the second approach has to solve a much larger op-timization problem proportional to K by the algorithms developed so far. In this paper, following the second approach, we present a novel multi-class large margin classifier (MLMC). This new machine can solve K-class problems in one optimization formula-tion without increasing the size of the quadratic programming (QP) problem proportional to K. This property allows us to construct just one classifier with as few variables in the QP problem as possible to classify multi-class data, and we can gain the advantage of speed from it especially when K is large. Our experiments indicate that MLMC almost works as well as (sometimes better than) many other multi-class SVCs for some benchmark data classification problems, and obtains a reasonable performance in face recognition application on the AR face database.

  5. Determining the COB location along the Iberian margin and Galicia Bank from gravity anomaly inversion, residual depth anomaly and subsidence analysis (United States)

    Cowie, Leanne; Kusznir, Nick; Manatschal, Gianreto


    Knowledge and understanding of the ocean-continent transition (OCT) structure, continent-ocean boundary (COB) location and crustal type are of critical importance in evaluating rifted continental margin formation and evolution. OCT structure, COB location and magmatic type also have important implications for the understanding of the geodynamics of continental breakup and in the evaluation of petroleum systems in deep-water frontier oil and gas exploration at rifted continental margins. Mapping the distribution of thinned continental crust and lithosphere, its distal extent and the start of unequivocal oceanic crust and hence determining the OCT structure and COB location at rifted continental margins is therefore a generic global problem. In order to assist in the determination of the OCT structure and COB location, we present methodologies using gravity anomaly inversion, residual depth anomaly (RDA) analysis and subsidence analysis, which we apply to the west Iberian rifted continental margin. The west Iberian margin has one of the most complete data sets available for deep magma-poor rifted margins, so there is abundant data to which the results can be calibrated. Gravity anomaly inversion has been used to determine Moho depth, crustal basement thickness and continental lithosphere thinning; subsidence analysis has been used to determine the distribution of continental lithosphere thinning; and RDAs have been used to investigate the OCT bathymetric anomalies with respect to expected oceanic bathymetries at rifted continental margins. These quantitative analytical techniques have been applied to the west Iberian rifted continental margin along profiles IAM9, Lusigal 12 (with the TGS-extension) and ISE-01. Our predictions of OCT structure, COB location and magmatic type (i.e. the volume of magmatic addition, whether the margin is `normal' magmatic, magma-starved or magma-rich) have been tested and validated using ODP wells (Legs 103, 149 and 173), which provide

  6. SU-E-T-160: Evaluation of Accuracy for Target Margin Size Obtained From CBCT On Lung SBRT Based On Film Dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S; Lee, M; Kim, M; Suh, T [The Catholic University of Korea, Seoul (Korea, Republic of); Park, J [Stanford University, Stanford, CA (United States); Park, S [The Catholic University of Korea, Seoul (Korea, Republic of); The Catholic University of Korea Uijeongbu St. Mary' s Hospital, Uijeongbu, Gyeonggi (Korea, Republic of)


    Purpose: To analysis delivered dose on target using gafchromic films for evaluating accuracy of target margin size obtained from cone beam computed tomography (CBCT) during lung stereotactic body radiation therapy (SBRT) Methods: The phantom consists of measurement part and driving part. The motor of Quasar motion phantom (Modus Medical Devices Inc, London, ON, Canada) was used for driving part and we developed measurement part which consist of cork cylindrical body and acrylic target with radiochromic film inserted into central and both ends of acrylic target. In this study lung SBRT cases through both four dimensional computed tomography (4DCT) and CBCT were selected. Target contouring including margin based on 4DCT is defined with a 1 cm margin around gross tumor volume (GTV) in all directions except for inferior direction. The moving range in inferior direction was larger than other directions thus, including 2 cm margin. In case of CBCT, the margin means blurring of target on CBCT images. This study was compared margin size determined through 4DCT and that of based on CBCT and we also evaluated dose profile and the length of margin in superior-inferior direction on CBCT compared with 4DCT. Results: The length of target including margin was 2.48 cm (based on CBCT) and 2.66 cm (based on 4DCT), respectively in superior-inferior direction. The difference of delivered dose on target between two margins was only within 1%. Conclusions: This study has shown the feasibility of determining target margin using CBCT for delivering more accurate prescription dose to lung cancer.

  7. Marginal dietary zinc concentration affects claw conformation measurements but not histological claw characteristics in weaned pigs. (United States)

    van Riet, Miriam M J; Janssens, Geert P J; Cornillie, Pieter; Van Den Broeck, Wim; Nalon, Elena; Ampe, Bart; Tuyttens, Frank A M; Maes, Dominiek; Du Laing, Gijs; Millet, Sam


    The aim of the present study was to explore whether marginal dietary zinc (Zn) concentrations affect claw quality measurements in weaned pigs. Twenty-four weaned pigs were randomly assigned to two dietary treatment groups: (1) 42 mg Zn/kg diet from ingredients only (unsupplemented, marginal dietary Zn concentration below Zn requirements of 80 mg Zn/kg feed); and (2) 106 mg Zn/kg diet, where Zn was added as ZnO (common commercial dietary Zn concentration). Claw conformation characteristics were measured at the start (day 0, 4 weeks of age) and at the end (day 36) of the study, and the histological claw characteristics of horn wall and heel horn were examined on samples collected at 9 weeks of age. Non-supplemented pigs had narrower claw widths (P= 0.028) and lower toe heights (P= 0.010) at 9 weeks. The length of the dorsal border tended to be lower for the non-supplemented piglets (P= 0.092). Claw volume and claw horn size were lower (P= 0.003 and P pigs at 9 weeks of age. Horn growth and wear were lower for the non-supplemented pigs (P= 0.044 and P dietary Zn concentration affected various claw quality measurements. Marginal dietary Zn concentrations may not be sufficient to maintain claw quality in pigs.

  8. Evolutionary Marginal Cost Pricing Scheme Implementation Based on Stochastic Traffic Flow Information

    Directory of Open Access Journals (Sweden)

    Wei Xu


    Full Text Available Traditionally, to implement the first-best marginal cost pricing scheme in a traffic network requires the information on the exact demand function or true origin-destination demand, which, however, is rarely available in practice. To overcome this dilemma, the trial-and-error method has been proposed to find the marginal cost toll through an iterative process using the observed traffic volumes. This method guarantees the convergence of tolls and flows to the system optimal state under the assumption of deterministic traffic conditions. However, in reality, the uncertainty of transportation network has been recognized well that induces the variability of link flow and travel time. Therefore, this paper proposes an evolutionary implementation method that iteratively finds the first-best marginal cost toll pattern according to the observed stochastic link flow information and the known travel time functions. The proof of the convergence of the iterative algorithm is presented. The paper also analyzes the effect of the sampling error of the link flow data on the convergence of the algorithm and shows that the biases from the flow observation will not affect the convergence. The numerical tests are provided for the illustration of the algorithm.

  9. Exploration Breakthrough in Southern Margin of Junggar Basin

    Institute of Scientific and Technical Information of China (English)

    Kang Zhulin; Zheng Jiandong


    @@ The Hutubi structure, located in the southern margin of Junggar Basin, is 60 km norrthwest of Urumqi and 20 km northwest of Changji (Fig. l). The Hu-2 well drilled in the Hutubi structure has gained high-yield gas flow,significant exploration breakthrough in the southern margin of Junggar Basin since the 1950s.

  10. Analytic solutions for marginal deformations in open superstring field theory

    Energy Technology Data Exchange (ETDEWEB)

    Okawa, Y.


    We extend the calculable analytic approach to marginal deformations recently developed in open bosonic string field theory to open superstring field theory formulated by Berkovits. We construct analytic solutions to all orders in the deformation parameter when operator products made of the marginal operator and the associated superconformal primary field are regular. (orig.)

  11. Estimating Marginal Returns to Education. NBER Working Paper No. 16474 (United States)

    Carneiro, Pedro; Heckman, James J.; Vytlacil, Edward J.


    This paper estimates the marginal returns to college for individuals induced to enroll in college by different marginal policy changes. The recent instrumental variables literature seeks to estimate this parameter, but in general it does so only under strong assumptions that are tested and found wanting. We show how to utilize economic theory and…

  12. Assessment of Biomass Resources from Marginal Lands in APEC Economies

    Energy Technology Data Exchange (ETDEWEB)

    Milbrandt, A.; Overend, R. P.


    The goal of this study is to examine the marginal lands in Asia-Pacific Economic Cooperation (APEC) economies and evaluate their biomass productivity potential. Twelve categories of marginal lands are identified using the Global Agro-Ecological Zones system of the United Nations Food and Agriculture Organization.

  13. Carbonate mound development in contrasting settings on the Irish margin

    NARCIS (Netherlands)

    van der Land, C.; Eisele, M.; Mienis, F; de Haas, H.; Hebbeln, D.; Reijmer, J.J.G.; van Weering, T.C.E.


    Cold-water coral carbonate mounds, formed by framework building cold-water corals, are found in several mound provinces on the Irish margin. Differences in cold-water coral mound development rates and sediment composition between mounds at the southwest Rockall Trough margin and the Galway Mound in

  14. Lorna Dee Cervantes: A Writer in the Margins. (United States)

    Connelly, Colette

    Chicana literary authors are sometimes thought to occupy the edges of two "texts," their own culture and the Anglo-American hegemony, where they are oppressed and marginalized by sexism and racism. In these margins, however, Chicana authors can dismantle stereotypes and construct new and empowering images of self. As an example of this…

  15. Challenging conservation agriculture on marginal slopes in Sehoul, Morocco

    NARCIS (Netherlands)

    Schwilch, G.; Laouina, A.; Chaker, M.; Machouri, N.; Sfa, M.; Stroosnijder, L.


    In Sehoul, Morocco, the use of marginal land for agriculture became a necessity for the local population due to increased poverty and the occupation of the best land by new owners. Desertification poses an additional threat to agricultural production on marginal slopes, which are often stony and deg

  16. Molecular markers in the surgical margin of oral carcinomas

    DEFF Research Database (Denmark)

    Bilde, Anders; von Buchwald, Christian; Dabelsteen, Erik


    epithelium in the surgical resection margin may explain the local recurrence rate. The purpose of this study is to investigate the presence of senescence markers, which may represent early malignant changes in the margin that in routine pathological evaluations are classified as histologically normal...

  17. Supervised linear dimensionality reduction with robust margins for object recognition (United States)

    Dornaika, F.; Assoum, A.


    Linear Dimensionality Reduction (LDR) techniques have been increasingly important in computer vision and pattern recognition since they permit a relatively simple mapping of data onto a lower dimensional subspace, leading to simple and computationally efficient classification strategies. Recently, many linear discriminant methods have been developed in order to reduce the dimensionality of visual data and to enhance the discrimination between different groups or classes. Many existing linear embedding techniques relied on the use of local margins in order to get a good discrimination performance. However, dealing with outliers and within-class diversity has not been addressed by margin-based embedding method. In this paper, we explored the use of different margin-based linear embedding methods. More precisely, we propose to use the concepts of Median miss and Median hit for building robust margin-based criteria. Based on such margins, we seek the projection directions (linear embedding) such that the sum of local margins is maximized. Our proposed approach has been applied to the problem of appearance-based face recognition. Experiments performed on four public face databases show that the proposed approach can give better generalization performance than the classic Average Neighborhood Margin Maximization (ANMM). Moreover, thanks to the use of robust margins, the proposed method down-grades gracefully when label outliers contaminate the training data set. In particular, we show that the concept of Median hit was crucial in order to get robust performance in the presence of outliers.

  18. Marginal Assessment of Crowns by the Aid of Parallel Radiography

    Directory of Open Access Journals (Sweden)

    Farnaz Fattahi


    Full Text Available Introduction: Marginal adaptation is the most critical item in long-term prognosis of single crowns. This study aimed to assess the marginal quality as well asthe discrepancies in marginal integrity of some PFM single crowns of posterior teeth by employing parallel radiography in Shiraz Dental School, Shiraz, Iran. Methods: In this descriptive study, parallel radiographies were taken from 200 fabricated PFM single crowns of posterior teeth after cementation and before discharging the patient. To calculate the magnification of the images, a metallic sphere with the thickness of 4 mm was placed in the direction of the crown margin on the occlusal surface. Thereafter, the horizontal and vertical space between the crown margins, the margin of preparations and also the vertical space between the crown margin and the bone crest were measured by using digital radiological software. Results: Analysis of data by descriptive statistics revealed that 75.5% and 60% of the cases had more than the acceptable space (50µm in the vertical (130±20µm and horizontal (90±15µm dimensions, respectively. Moreover, 85% of patients were found to have either horizontal or vertical gap. In 77% of cases, the margins of crowns invaded the biologic width in the mesial and 70% in distal surfaces. Conclusion: Parallel radiography can be expedient in the stage of framework try-in to yield some important information that cannot be obtained by routine clinical evaluations and may improve the treatment prognosis

  19. Carbonate mound development in contrasting settings on the Irish margin

    NARCIS (Netherlands)

    van der Land, C.; Eisele, M.; Mienis, F; de Haas, H.; Hebbeln, D.; Reijmer, J.J.G.; van Weering, T.C.E.


    Cold-water coral carbonate mounds, formed by framework building cold-water corals, are found in several mound provinces on the Irish margin. Differences in cold-water coral mound development rates and sediment composition between mounds at the southwest Rockall Trough margin and the Galway Mound in

  20. Becoming Marginalized in a Middle School Physical Education Class. (United States)

    Smith, Barbara Tyree; Goc-Karp, Grace

    This study examined the effects of social competence, group formation, and group behavior on the marginalization of students in a 7th-grade physical education setting. Marginalized students are defined as those in the class, but not "of" the class. In addition, factors such as individual and team activity and teacher expectations help to…

  1. Power margin improvement for OFDMA-PON using hierarchical modulation. (United States)

    Cao, Pan; Hu, Xiaofeng; Zhuang, Zhiming; Zhang, Liang; Chang, Qingjiang; Yang, Qi; Hu, Rong; Su, Yikai


    We propose and experimentally demonstrate a hierarchical modulation scheme to improve power margin for orthogonal frequency division multiple access-passive optical networks (OFDMA-PONs). In a PON system, under the same launched optical power, optical network units (ONUs) have different power margins due to unequal distribution fiber lengths. The power margin of the PON system is determined by the ONU with the lowest power margin. In our proposed scheme, ONUs with long and short distribution fibers are grouped together, and downstream signals for the paired ONUs are mapped onto the same OFDM subcarriers using hierarchical modulation. In a pair of ONUs, part of the power margin of the ONU with short distribution fiber is re-allocated to the ONU with long distribution fiber. Therefore, the power margin of the ONU with the longest distribution fiber can be increased, leading to the power margin improvement of the PON system. Experimental results show that the hierarchical modulation scheme improves the power margin by 2.7 dB for an OFDMA-PON system, which can be used to support more users or extend transmission distance.

  2. New evidence for ice shelf flow across the Alaska and Beaufort margins, Arctic Ocean (United States)

    Engels, Jennifer L.

    The Arctic Ocean may act as a lynchpin for global climate change due to its unique physiography as a mediterranean sea located in polar latitudes. In our modern warming climate, debate over the bounds of natural versus anthropogenically-induced climate variability necessitates a comprehensive understanding of Arctic ice extent and configuration over the last interglacial cycle. Longstanding controversy exists as to the volume, timing, and flow trajectories of ice in the Arctic Ocean during glacial maxima when continental ice sheets mantled circum-arctic landmasses. As a result of the Science Ice Exercise surveys of the Arctic Ocean in 1999, new evidence for ice grounding at depths down to 980 m on the Lomonosov Ridge and 750 m on the Chukchi Borderland indicates the likelihood that large ice shelves flowed into the ocean from both the Barents/Kara Sea and the Canadian Arctic Archipelago or eastern Alaska. Sidescan imagery of ˜14100 km2 of seafloor along the Alaska and Beaufort margins in water depths from 250--2800 m maps a repetitive association of recognizable sub-glacially generated bedforms, ice carved-bathymerry, and ice-marginal turbidite gullies over a 640 km stretch of the margin between Point Barrow and the MacKenzie River delta. Glaciogenic bedforms occur across the surface of a flattened bathymetric bench or 'second shelf break' that is interpreted to have been formed by an ice shelf eroding the continental slope. The glacial geology of surrounding areas suggests that an ice shelf on the Alaska and Beaufort margins likely flowed from the mouths of overdeepened glacial troughs in the Canadian Arctic Archipelago westward and across the Chukchi Borderland due to an obstruction in the central Canadian basin. Evidence for an ice shelf along the Alaska and Beaufort margins supports an expanded interpretation of ice volume and extent during Pleistocene glacial periods. This has far-reaching implications for Arctic climate studies, ocean circulation, sediment

  3. Geophysical constraints on geodynamical processes at convergent margins

    DEFF Research Database (Denmark)

    Artemieva, Irina; Thybo, Hans; Shulgin, Alexey


    Convergent margins, being the boundaries between colliding lithospheric plates, form the most disastrous areas in the world due to intensive, strong seismicity and volcanism. We review global geophysical data in order to illustrate the effects of the plate tectonic processes at convergent margins...... on the crustal and upper mantle structure, seismicity, and geometry of subducting slab. We present global maps of free-air and Bouguer gravity anomalies, heat flow, seismicity, seismic Vs anomalies in the upper mantle, and plate convergence rate, as well as 20 profiles across different convergent margins....... A global analysis of these data for three types of convergent margins, formed by ocean-ocean, ocean-continent, and continent-continent collisions, allows us to recognize the following patterns. (1) Plate convergence rate depends on the type of convergent margins and it is significantly larger when...

  4. Studying media at The Margins: learning from the field

    Directory of Open Access Journals (Sweden)

    Clemencia Rodríguez


    Full Text Available This article, informed by ethnographic research on media at the margins, proposes a shift in perspective at several different levels: 1 instead of focusing on individual technologies, our research should examine how grassroots communicators operating at the margins exist in a media ecology that offers different potentialities in each historical situation; 2 instead of trying to determine if the media technologies used at the margin are old or new, digital or not digital, we need to explore how embedded community communicators detect local information or communication needs and use available technologies to address these needs; 3 our research on media at the margins should shed light on how grassroots communicators re-invent, hybridize, converge, and bridge technologies from one platform to another. In sum, understanding media at the margins is about embracing complexity, maintaining the notion of media ecologies, and understanding how grassroots communicators, deeply embedded in local contexts, wedge media technologies into everyday life.

  5. Molecular markers in the surgical margin of oral carcinomas

    DEFF Research Database (Denmark)

    Bilde, A.; Buchwald, C. von; Dabelsteen, E.;


    BACKGROUND: Local or regional lymph node recurrence is the most common pattern of treatment failure in oral squamous cell carcinoma (SCC). The local recurrence rate is 30% even when the surgical resection margin is diagnosed as tumour free. Accumulation of genetic changes in histologically normal...... epithelium in the surgical resection margin may explain the local recurrence rate. The purpose of this study is to investigate the presence of senescence markers, which may represent early malignant changes in the margin that in routine pathological evaluations are classified as histologically normal....... METHODS: Formalin-fixed, paraffin-embedded surgical specimens from 16 consecutive patients with oral SCC and a clear surgical margin were obtained. The margin was analysed by immunohistochemistry for p53, p16, Chk2, Laminin-5 and glycosylated oncofetal fibronectin. RESULTS: Two patterns of p53 expression...

  6. A simplified approach to the complete porcelain margin. (United States)

    Vryonis, P


    The technique described produces a metal-ceramic crown exhibiting excellent esthetic qualities and marginal accuracy superior to that achieved on the cast metal margin. A platinum foil apron or refractory dies are not necessary. A precise shoulder preparation, preferably with two master dies, is required. A chamfer with a bevel, a shoulder with a bevel, or chamfer preparations are not suited to this technique. Quantitative evaluation using a measuring microscope showed that a marginal gap on a crown fabricated on an International Bureau of Standards crown die measured 6 microns at the porcelain shoulder and from 17 to 34 microns on a gold margin of the same crown. On a prepared-tooth, rubber-base compression densite die, the marginal gap on the porcelain shoulder was 10 microns.

  7. Marginality and Social Rejection in Amiri Baraka's Slave Ship

    Directory of Open Access Journals (Sweden)

    Hamid Hammad Abed


    Full Text Available Marginality and social rejection are the most influential matters exploited by Baraka to intentionally criticize the American society.  More often than not, these two matters have become the scenes of major or minor acts of humiliation and dehumanization that threaten to violate the ethical rules of living. This paper aims at investigating the impact of marginality and social rejection on a number of black characters in Baraka's Slave Ship who are brought to America to be sold as commodities. It is divided into two sections and conclusion. Section one deals with Amiri Baraka’s dramatic thought and experience of marginality within the American society. The textual analysis of Slave Ship is investigated in section two. The significance of the study lies in its textual exploration of the impact of marginality and social rejection in subverting the American dream of democracy, freedom, and equality in Baraka’s Slave Ship. Keywords: marginality, Baraka, rejection, slave ship, black

  8. Margins of oral leukoplakia: autofluorescence and histopathology. (United States)

    Elvers, D; Braunschweig, T; Hilgers, R-D; Ghassemi, A; Möhlhenrich, S C; Hölzle, F; Gerressen, M; Modabber, A


    Autofluorescence devices are widely used to examine oral lesions. The aim of this study was to see whether there were any signs of dysplasia, parakeratosis, or mucosal inflammation in the borders of homogeneous oral leukoplakia using autofluorescence, and we also compared clinically visible extensions with those detected by autofluorescence. Twenty patients with 26 homogeneous areas of oral leukoplakia were included in the study. After the clinically visible extensions of the lesion had been marked, we took a photograph through the autofluorescence device, which showed both borders in one picture. We then used photo-editing software to measure the size of the area of leukoplakia together with the area with loss of autofluorescence. We took 3 punch biopsy specimens: one from the leukoplakia, one 2.5mm from its marked borders, and one from healthy mucosa. Seventy-eight biopsy specimens were examined by an experienced pathologist, and 95% CI calculated to assess the amount of parakeratosis. Spearman's rank correlation was used to assess the association with mucosal inflammation. Ten areas of leukoplakia were surrounded by normal green autofluorescence, and 16 were consistent with loss of autofluorescence with a mean size of 66%, which exceeded the clinically visible size of the area of leukoplakia. We calculated that there was a strong association between these entities and their surrounding areas, with loss of autofluorescence for parakeratosis. Some leukoplakias showed clinically invisible extensions during histopathological examination and autofluorescence. The technique described enables clinicians to measure the extent of these lesions beyond their visible margins. We found no dysplasia, which emphasises that autofluorescence detects non-dysplastic lesions caused by mucosal inflammation and parakeratosis.

  9. Coral reef evolution on rapidly subsiding margins (United States)

    Webster, J.M.; Braga, J.C.; Clague, D.A.; Gallup, C.; Hein, J.R.; Potts, D.C.; Renema, W.; Riding, R.; Riker-Coleman, K.; Silver, E.; Wallace, L.M.


    A series of well-developed submerged coral reefs are preserved in the Huon Gulf (Papua New Guinea) and around Hawaii. Despite different tectonics settings, both regions have experienced rapid subsidence (2-6??m/ka) over the last 500??ka. Rapid subsidence, combined with eustatic sea-level changes, is responsible for repeated drowning and backstepping of coral reefs over this period. Because we can place quantitative constraints on these systems (i.e., reef drowning age, eustatic sea-level changes, subsidence rates, accretion rates, basement substrates, and paleobathymetry), these areas represent unique natural laboratories for exploring the roles of tectonics, reef accretion, and eustatic sea-level changes in controlling the evolution of individual reefs, as well as backstepping of the entire system. A review of new and existing bathymetric, radiometric, sedimentary facies and numerical modeling data indicate that these reefs have had long, complex growth histories and that they are highly sensitive, recording drowning not only during major deglaciations, but also during high-frequency, small-amplitude interstadial and deglacial meltwater pulse events. Analysis of five generalized sedimentary facies shows that reef drowning is characterized by a distinct biological and sedimentary sequence. Observational and numerical modeling data indicate that on precessional (20??ka) and sub-orbital timescales, the rate and amplitude of eustatic sea-level changes are critical in controlling initiation, growth, drowning or sub-aerial exposure, subsequent re-initiation, and final drowning. However, over longer timescales (> 100-500??ka) continued tectonic subsidence and basement substrate morphology influence broad scale reef morphology and backstepping geometries. Drilling of these reefs will yield greatly expanded stratigraphic sections compared with similar reefs on slowly subsiding, stable and uplifting margins, and thus they represent a unique archive of sea-level and climate

  10. Vibrational anomalies and marginal stability of glasses

    KAUST Repository

    Marruzzo, Alessia


    The experimentally measured vibrational spectrum of glasses strongly deviates from that expected in Debye\\'s elasticity theory: The density of states deviates from Debye\\'s ω2 law ("boson peak"), the sound velocity shows a negative dispersion in the boson-peak frequency regime, and there is a strong increase in the sound attenuation near the boson-peak frequency. A generalized elasticity theory is presented, based on the model assumption that the shear modulus of the disordered medium fluctuates randomly in space. The fluctuations are assumed to be uncorrelated and have a certain distribution (Gaussian or otherwise). Using field-theoretical techniques one is able to derive mean-field theories for the vibrational spectrum of a disordered system. The theory based on a Gaussian distribution uses a self-consistent Born approximation (SCBA),while the theory for non-Gaussian distributions is based on a coherent-potential approximation (CPA). Both approximate theories appear to be saddle-point approximations of effective replica field theories. The theory gives a satisfactory explanation of the vibrational anomalies in glasses. Excellent agreement of the SCBA theory with simulation data on a soft-sphere glass is reached. Since the SCBA is based on a Gaussian distribution of local shear moduli, including negative values, this theory describes a shear instability as a function of the variance of shear fluctuations. In the vicinity of this instability, a fractal frequency dependence of the density of states and the sound attenuation ∝ ω1+a is predicted with a ≲ 1/2. Such a frequency dependence is indeed observed both in simulations and in experimental data. We argue that the observed frequency dependence stems from marginally stable regions in a glass and discuss these findings in terms of rigidity percolation. © 2013 EDP Sciences and Springer.

  11. Head and Neck Margin Reduction With Adaptive Radiation Therapy: Robustness of Treatment Plans Against Anatomy Changes. (United States)

    van Kranen, Simon; Hamming-Vrieze, Olga; Wolf, Annelisa; Damen, Eugène; van Herk, Marcel; Sonke, Jan-Jakob


    We set out to investigate loss of target coverage from anatomy changes in head and neck cancer patients as a function of applied safety margins and to verify a cone beam computed tomography (CBCT)-based adaptive strategy with an average patient anatomy to overcome possible target underdosage. For 19 oropharyngeal cancer patients, volumetric modulated arc therapy treatment plans (2 arcs; simultaneous integrated boost, 70 and 54.25 Gy; 35 fractions) were automatically optimized with uniform clinical target volume (CTV)-to-planning target volume margins of 5, 3, and 0 mm. We applied b-spline CBCT-to-computed tomography (CT) deformable registration to allow recalculation of the dose on modified CT scans (planning CT deformed to daily CBCT following online positioning) and dose accumulation in the planning CT scan. Patients with deviations in primary or elective CTV coverage >2 Gy were identified as candidates for adaptive replanning. For these patients, a single adaptive intervention was simulated with an average anatomy from the first 10 fractions. Margin reduction from 5 mm to 3 mm to 0 mm generally led to an organ-at-risk (OAR) mean dose (Dmean) sparing of approximately 1 Gy/mm. CTV shrinkage was mainly seen in the elective volumes (up to 10%), likely related to weight loss. Despite online repositioning, substantial systematic errors were present (>3 mm) in lymph node CTV, the parotid glands, and the larynx. Nevertheless, the average increase in OAR dose was small: maximum of 1.2 Gy (parotid glands, Dmean) for all applied margins. Loss of CTV coverage >2 Gy was found in 1, 3, and 7 of 73 CTVs, respectively. Adaptive intervention in 0-mm plans substantially improved coverage: in 5 of 7 CTVs (in 6 patients) to 2 Gy in 0-mm plans may be identified early in treatment using dose accumulation. A single intervention with an average anatomy derived from CBCT effectively mitigates discrepancies. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Dosimetric consequences of tumor volume changes after kilovoltage cone-beam computed tomography for non-operative lung cancer during adaptive intensity-modulated radiotherapy or fractionated stereotactic radiotherapy

    Institute of Scientific and Technical Information of China (English)

    Jian Hu; Ximing Xu; Guangjin Yuan; Wei Ge; Liming Xu; Aihua Zhang; Junjian Deng


    Objective The aim of this study was to investigate tumor volume changes with kilovoltage cone-beam computed tomography (kV-CBCT) and their dosimetric consequences for non-operative lung cancer during intensity-modulated radiotherapy (IMRT) or fractionated stereotactic radiotherapy. Methods Eighteen patients with non-operative lung cancer who received IMRT consisting of 1.8-2.2 Gy/fraction and five fractions per week or stereotactic radiotherapy with 5-8 Gy/fraction and three fractions a week were studied. kV-CBCT was performed once per week during IMRT and at every fraction during stereotactic radiotherapy. The gross tumor volume (GTV) was contoured on the kV-CBCT images, and adaptive treatment plans were created using merged kV-CBCT and primary planning computed tomogra-phy image sets. Tumor volume changes and dosimetric parameters, including the minimum dose to 95%(D95) or 1% (D1) of the planning target volume (PTV), mean lung dose (MLD), and volume of lung tissue that received more than 5 (V5), 10 (V10), 20 (V20), and 30 (V30) Gy were retrospectively analyzed. Results The average maximum change in GTV observed during IMRT or fractionated stereotactic radio-therapy was -25.85% (range, -13.09% --56.76%). The D95 and D1 of PTV for the adaptive treatment plans in all patients were not significantly different from those for the initial or former adaptive treatment plans. In patients with tumor volume changes of >20% in the third or fourth week of treatment during IMRT, adap-tive treatment plans offered clinically meaningful decreases in MLD and V5, V10, V20, and V30; however, in patients with tumor volume changes of 20% in the third or fourth week of treatment.

  13. City and sea margins. Porto’s Marginal as scale and measure of new spaces

    Directory of Open Access Journals (Sweden)

    Giuseppe Parità


    Full Text Available The city has always been confronting with its own end and the beginning of the water system. Among the different kind of margin areas, the ones that border the cities on their watersides are particularly interesting. These new liminal territories are rich in variety and differences and are set up of several elements made of different morphologies that should be carefully read and interpreted: the need of re-thinking the morphological elements that mark an urban edge leads to the identification of several shapes and forms of the water borderlands. Borders, limits, boundaries, edges, margin areas - usually considered as an obstacle to the construction of the city - turn themselves as new possible “design materials” for building that ambiguous distance between city and the sea. The article aims to focus on the case-study of Porto’s Marginal that well explain how many ways a city can live its water edges. On a large scale, it is configured as a strip of 15 kilometers of public space. Within this continuity, the different extent of the distance between city and water leads to reflect on the different types of relationships (and therefore projects between the end of one side and the beginning of another. For Porto, those are not only urban parts, but also different geographical parts (sea, rivers, topography that distance puts in relation through the design sometimes of the line, at time of the border or of a surface. So, the analysis of these heterogeneous but continuous projects aim to focus on the several techniques of urban composition to build contemporary public spaces. On one hand they give form to a continuous “public figure”, on the other hand each one of the project can be considered as part of a “atlas” of liminal places, giving form to public spaces. 

  14. Tiago Marques Aipobureu: um bororo marginal Tiago Marques Aipobureu: a Bororo on the margins

    Directory of Open Access Journals (Sweden)

    Florestan Fernandes


    Full Text Available O texto analisa a biografia de um membro da tribo dos Bororo, Tiago Marques Aipobureu, que, nascido no planalto oriental de Mato Grosso, foi levado pelos missionários para estudar em Cuiabá e depois viajou pela Europa. Quando de seu retorno ao Brasil, foi empregado como professor, mas não conseguiu adaptar-se à nova vida. Casado com uma mulher de sua tribo, buscou então reintegrar-se aos Bororo, igualmente sem sucesso. Permanecia, desse modo, no meio do caminho, incapaz de integrar-se plenamente tanto à sociedade e cultura "civilizadas" como à sociedade e cultura indígenas. O desajustamento de Tiago evidencia a situação do homem marginal, daquele que se situa na divisa de duas raças, na margem de duas culturas sem conseguir pertencer integralmente a nenhuma delas.The text analyzes the biography of a member of the Bororo tribe, Tiago Marques Aipobureu. Born on the eastern plateau of Mato Grosso, he was taken by missionaries to study in Cuiabá and later travelled through Europe. On returning to Brazil, he was employed as a teacher, but was unable to adapt to his new life. Married to a woman from his tribe, he tried to rejoin the Bororo, likewise without success. Thus he found himself midway between worlds, unable to join fully either 'civilized' society and culture, or indigenous society and culture. Tiago's maladjustment exemplifies the situation of the marginal person, someone situated on the dividing line between two races, on the margin of two cultures, unable to belong wholly to either.

  15. The effects of photodynamic laser therapy in the treatment of marginal chronic periodontitis (United States)

    Chifor, Radu; Badea, Iulia; Avram, Ramona; Chifor, Ioana; Badea, Mîndra Eugenia


    The aim of this study was to assess the effects of the antimicrobial photodynamic laser therapy performed during the treatment of deep periodontal disease by using 40 MHz high frequency ultrasonography. The periodontal data recorded during the clinical examination before each treatment session were compared with volumetric changes of the gingiva measured on periodontal ultrasound images. The results show a significant decrease of gingival tissue inflammation proved both by a significant decrease of bleeding on probing as well as by a decrease of the gingival tissues volume on sites where the laser therapy was performed. Periodontal tissues that benefit of laser therapy besides classical non-surgical treatment showed a significant clinical improvement of periodontal status. Based on these findings we were able to conclude that the antimicrobial photodynamic laser therapy applied on marginal periodontium has important anti-inflamatory effect. The periodontal ultrasonography is a method which can provide useful data for assessing the volume changes of gingival tissues, allowing a precise monitoring of marginal periodontitis.

  16. Utilization of contribution margin in the costing system in production of components for wood working machines

    Directory of Open Access Journals (Sweden)

    Marek Potkány


    Full Text Available The aim of this paper is to propose optimization of costing method for planning a production-sales programme of the chosen engineering enterprise dealing with the production of components for wood working machines. This engineering company uses the calculation pattern methodology in the comprehensive cost accounting system. All costs components are absorbed by individual outputs in this cost calculation. The results of this calculation are not available for decision-making tasks. In order to solve the decision tasks relating to output assortment optimization, it is necessary to show separately variable costs influenced by changes in production volume and fixed costs not influenced by changes in production volume. For these reasons we propose a specific application of retrograde costing as a necessary condition for effective system of decision-making on the basis of contribution margin calculation. The contribution margin/standard hour is the criteria for the calculation in a critical place of production and this is very important information for developing an optimal production-sales programme.

  17. CD27 expression in the human splenic marginal zone : the infant marginal zone is populated by naive B cells

    NARCIS (Netherlands)

    Zandvoort, A; Lodewijk, ME; de Boer, NK; Dammers, PM; Kroese, FGM; Timens, W


    The splenic marginal zone of adult humans contains B cells, of which most express CD27, an antigen only recently identified as a marker for somatically, mutated memory B cells. We investigated whether and to which extent the developing marginal zone in infants arid children is populated by either

  18. Alterations of the marginal soft tissue (gingival margin following periodontal therapy: A clinical study

    Directory of Open Access Journals (Sweden)

    Gupta Ira


    Full Text Available Background and Objectives: The evaluation of gingival margin position (GMP plays a vital role in periodontal therapy and is critical in esthetic/plastic surgical procedures revolving around restorative dentistry. Comparative evaluations of GMP measurements in various periodontal therapies are scarce. Thus, the objectives of this study are to measure the alteration in the gingival margin position following various therapies, and to compare GMP alterations among different treatment modalities from the baseline to six months after therapy. Materials and Methods: The changes in GMP were studied for MB, B, DB, ML, and L sites for SRP, curettage, and flap surgery, and for MB, B, and DB sites for crown lengthening cases at the end of one, three, and six months after therapy. The results were interpreted from baseline to one, three, and six months posttreatment. Statistical Analysis : The results were subjected to statistical analysis. Paired ′t′-test was used for intra-group comparisons and intergroup comparisons were done by one-way ANOVA. Results: The GMP changed from baseline in all the sites at different time periods following various therapies. The net results after six months were an apical shift of GMP in SRP, curettage, and flap surgery, and a coronal shift of GMP in crown lengthening. Conclusion: GMP shows various patterns of alteration after various periodontal therapies. One should wait for the GMP to become stable before attempting any restorative procedure.

  19. Quantifying Safety Margin Using the Risk-Informed Safety Margin Characterization (RISMC)

    Energy Technology Data Exchange (ETDEWEB)

    Grabaskas, David; Bucknor, Matthew; Brunett, Acacia; Nakayama, Marvin


    The Risk-Informed Safety Margin Characterization (RISMC), developed by Idaho National Laboratory as part of the Light-Water Reactor Sustainability Project, utilizes a probabilistic safety margin comparison between a load and capacity distribution, rather than a deterministic comparison between two values, as is usually done in best-estimate plus uncertainty analyses. The goal is to determine the failure probability, or in other words, the probability of the system load equaling or exceeding the system capacity. While this method has been used in pilot studies, there has been little work conducted investigating the statistical significance of the resulting failure probability. In particular, it is difficult to determine how many simulations are necessary to properly characterize the failure probability. This work uses classical (frequentist) statistics and confidence intervals to examine the impact in statistical accuracy when the number of simulations is varied. Two methods are proposed to establish confidence intervals related to the failure probability established using a RISMC analysis. The confidence interval provides information about the statistical accuracy of the method utilized to explore the uncertainty space, and offers a quantitative method to gauge the increase in statistical accuracy due to performing additional simulations.

  20. Influence of Crack Morphology on Leak Before Break Margins

    Energy Technology Data Exchange (ETDEWEB)

    Weilin Zang (Inspecta Technology AB, Stockholm (SE))


    The purpose of the project is to evaluate the deterministic LBB-margins for different pipe systems in a Swedish PWR-plant and using different crack morphology parameters. Results: - The influence of crack morphology on Leak Before Break (LBB) margins is studied. The subject of the report is a number of LBB-submittals to SKI where deterministic LBB-margins are reported. These submittals typically uses a surface roughness of 0.0762 mm (300 microinch) and number of turns equal to zero and an in-house code for the leak rate evaluations. The present report has shown that these conditions give the largest LBB-margins both in terms of the quotient between the critical crack length and the leakage crack size and for the leak rate margin. - Crack morphology parameters have a strong influence on the leak rate evaluations. Using the SQUIRT code and more recent recommendations for crack morphology parameters, it is shown that in many cases the evaluated margins, using 1 gpm as the reference leak rate detection limit, are below the safety factor of 2 on crack size and 10 on leak rate, which is generally required for LBB approval. - The effect of including weld residual stresses on the LBB margins is also investigated. It is shown that for the two examples studied, weld residual stresses were important for the small diameter thin wall pipe whereas it was negligible for the large diameter thick wall pipe which had a self-balanced weld residual stress distribution

  1. Wave speed structure of the eastern North American margin (United States)

    Savage, B.; Covellone, B. M.; Shen, Y.


    The eastern North American margin (ENAM) is the result of nearly a billion years of continental collision and rifting. To the west of this margin lies thick continental lithosphere of the North American craton, and to the east is oceanic lithosphere in the Atlantic. The substantial changes in lithosphere thickness at this boundary are thought to drive asthenosphere upwelling along the edge of the continent. Through iterative, full-waveform, ambient noise tomography, we observe a heterogeneous low wave speed margin along the continent in the upper mantle. Multiple low wave speed features imaged within the margin are consistent with asthenospeheric upwelling due to edge-driven convection. Also within the margin are high wave speed anomalies that maybe the remnants of eclogitic delamination of the Appalachian crustal root, which contribute to convection at the margin. Edge driven, small-scale convection keeps the margin weak and thus controls the large scale plate tectonic patterns and the crustal deformation. The imaged mantle wave speed anomalies, interpreted as edge-driven convection, correlate with and may increase the likelihood of damaging earthquakes in the eastern portion of North America.

  2. Assessment of Margins in Transoral Laser and Robotic Surgery

    Directory of Open Access Journals (Sweden)

    Yaniv Hamzany


    Full Text Available The growing practice of endoscopic surgery has changed the therapeutic management of selected head and neck cancers. Although a negative surgical margin in resection of neoplasm is the most important surgical principle in oncologic surgery, controversies exist regarding assessment and interpretation of the status of margin resection. The aim of this review was to summarize the literature considering the assessment and feasibility of negative margins in transoral laser microsurgery (TLM and transoral robotic surgery (TORS. Free margin status is being approached differently in vocal cord cancer (1–2 mm compared with other sites in the upper aerodigestive tract (2–5 mm. Exposure, orientation of the pathological specimen, and co-operation with the pathologist are crucial principles needed to be followed in transoral surgery. Piecemeal resection to better expose deep tumor involvement and biopsies taken from surgical margins surrounding site of resection can improve margin assessment. High rates of negative surgical margins can be achieved with TLM and TORS. Adjuvant treatment decision should take into consideration also the surgeon’s judgment with regard to the completeness of tumor resection.

  3. Stroke: a Hidden Danger of Margin Trading in Stock Markets. (United States)

    Lin, Shu-Hui; Wang, Chien-Ho; Liu, Tsai-Ching; Chen, Chin-Shyan


    Using 10-year population data from 2000 through 2009 in Taiwan, this is the first paper to analyze the relationship between margin trading in stock markets and stroke hospitalizations. The results show that 3 and 6 days after an increase of margin trading in the Taiwan stock markets are associated with greater stoke hospitalizations. In general, a 1 % increase in total margin trading positions is associated with an increment of 2.5 in the total number of stroke hospitalizations, where the mean number of hospital admissions is 233 cases a day. We further examine the effects of margin trading by gender and age groups and find that the effects of margin trading are significant for males and those who are 45-74 years old only. In summary, buying stocks with money you do not have is quite risky, especially if the prices of those stocks fall past a certain level or if there is a sudden and severe drop in the stock market. There is also a hidden danger to one's health from margin trading. A person should be cautious before conducting margin trading, because while it can be quite profitable, danger always lurks just around the corner.

  4. The dosimetric impact of daily setup error on target volumes and surrounding normal tissue in the treatment of prostate cancer with intensity-modulated radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Algan, Ozer, E-mail: [Department of Radiation Oncology, Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States); Jamgade, Ambarish; Ali, Imad; Christie, Alana; Thompson, J. Spencer; Thompson, David; Ahmad, Salahuddin; Herman, Terence [Department of Radiation Oncology, Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States)


    The purpose of this study was to evaluate the impact of daily setup error and interfraction organ motion on the overall dosimetric radiation treatment plans. Twelve patients undergoing definitive intensity-modulated radiation therapy (IMRT) treatments for prostate cancer were evaluated in this institutional review board-approved study. Each patient had fiducial markers placed into the prostate gland before treatment planning computed tomography scan. IMRT plans were generated using the Eclipse treatment planning system. Each patient was treated to a dose of 8100 cGy given in 45 fractions. In this study, we retrospectively created a plan for each treatment day that had a shift available. To calculate the dose, the patient would have received under this plan, we mathematically 'negated' the shift by moving the isocenter in the exact opposite direction of the shift. The individualized daily plans were combined to generate an overall plan sum. The dose distributions from these plans were compared with the treatment plans that were used to treat the patients. Three-hundred ninety daily shifts were negated and their corresponding plans evaluated. The mean isocenter shift based on the location of the fiducial markers was 3.3 {+-} 6.5 mm to the right, 1.6 {+-} 5.1 mm posteriorly, and 1.0 {+-} 5.0 mm along the caudal direction. The mean D95 doses for the prostate gland when setup error was corrected and uncorrected were 8228 and 7844 cGy (p < 0.002), respectively, and for the planning target volume (PTV8100) was 8089 and 7303 cGy (p < 0.001), respectively. The mean V95 values when patient setup was corrected and uncorrected were 99.9% and 87.3%, respectively, for the PTV8100 volume (p < 0.0001). At an individual patient level, the difference in the D95 value for the prostate volume could be >1200 cGy and for the PTV8100 could approach almost 2000 cGy when comparing corrected against uncorrected plans. There was no statistically significant difference in the D35

  5. Marginal grafts increase early mortality in liver transplantation

    Directory of Open Access Journals (Sweden)

    Telesforo Bacchella

    Full Text Available CONTEXT AND OBJECTIVE: Expanded donor criteria (marginal grafts are an important solution for organ shortage. Nevertheless, they raise an ethical dilemma because they may increase the risk of transplant failure. This study compares the outcomes from marginal and non-marginal graft transplantation in 103 cases of liver transplantation due to chronic hepatic failure. DESIGN AND SETTING: One hundred and three consecutive liver transplantations to treat chronic liver disease performed in the Liver Transplantation Service of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo between January 2001 and March 2006 were retrospectively analyzed. METHODS: We estimated graft quality according to a validated scoring system. We assessed the pre-transplantation liver disease category using the Model for End-Stage Liver Disease (MELD, as low MELD ( 20. The parameters for marginal and non-marginal graft comparison were the one-week, one-month and one-year recipient survival rates, serum liver enzyme peak, post-transplantation hospital stay and incidence of surgical complications and retransplantation. The significance level was 0.05. RESULTS: There were no differences between the groups regarding post-transplantation hospital stay, serum liver enzyme levels and surgical complications. In contrast, marginal grafts decreased overall recipient survival one month after transplantation. Furthermore, low-MELD recipients of non-marginal grafts showed better one-week and one-month survival than did high-MELD recipients of marginal livers. After the first month, patient survival was comparable in all groups up to one year. CONCLUSION: The use of marginal graft increases early mortality in liver transplantation, particularly among high-MELD recipients.

  6. Intraoperative ultrasound control of surgical margins during partial nephrectomy. (United States)

    Alharbi, Feras M; Chahwan, Charles K; Le Gal, Sophie G; Guleryuz, Kerem M; Tillou, Xavier P; Doerfler, Arnaud P


    To evaluate a simple and fast technique to ensure negative surgical margins on partial nephrectomies, while correlating margin statuses with the final pathology report. This study was conducted for patients undergoing partial nephrectomy (PN) with T1-T2 renal tumors from January 2010 to the end of December 2015. Before tumor removal, intraoperative ultrasound (US) localization was performed. After tumor removal and before performing hemostasis of the kidney, the specimens were placed in a saline solution and a US was performed to evaluate if the tumor's capsule were intact, and then compared to the final pathology results. In 177 PN(s) (147 open procedures and 30 laparoscopic procedures) were performed on 147 patients. Arterial clamping was done for 32 patients and the mean warm ischemia time was 19 ± 6 min. The mean US examination time was 41 ± 7 s. The US analysis of surgical margins was negative in 172 cases, positive in four, and in only one case it was not possible to conclude. The final pathology results revealed one false positive surgical margin and one false negative surgical margin, while all other margins were in concert with US results. The mean tumor size was 3.53 ± 1.43 cm, and the mean surgical margin was 2.8 ± 1.5 mm. The intraoperative US control of resection margins in PN is a simple, efficient, and effective method for ensuring negative surgical margins with a small increase in warm ischemia time and can be conducted by the operating urologist.

  7. Evolution of Devonian carbonate-shelf margin, Nevada (United States)

    Morrow, J.R.; Sandberg, C.A.


    The north-trending, 550-km-long Nevada segment of the Devonian carbonate-shelf margin, which fringed western North America, evidences the complex interaction of paleotectonics, eustasy, biotic changes, and bolide impact-related influences. Margin reconstruction is complicated by mid-Paleozoic to Paleogene compressional tectonics and younger extensional and strike-slip faulting. Reports published during the past three decades identify 12 important events that influenced development of shelf-margin settings; in chronological order, these are: (1) Early Devonian inheritance of Silurian stable shelf inargin, (2) formation of Early to early Middle 'Devonian shelf-margin basins, (3) propradation of later Middle Devonian shelf margin, (4) late Middle Devonian Taghanic ondap and continuing long-term Frasnian transgression, (5) initiation of latest Middle Devonian to early Frasnian proto-Antler orogenic forebulge, (6) mid-Frasnian Alamo Impact, (7) accelerated development of proto-Antler forebulge and backbulge Pilot basin, (8) global late Frasnian sentichatovae sea-level rise, (9) end-Frasnian sea-level fluctuations and ensuing mass extinction, (10) long-term Famennian regression and continept-wide erosion, (11) late Famennian emergence: of Ahtler orogenic highlands, and (12) end-Devonian eustatic sea-level fall. Although of considerable value for understanding facies relationships and geometries, existing standard carbonate platform-margin models developed for passive settings else-where do not adequately describe the diverse depositional and, structural settings along the Nevada Devonian platform margin. Recent structural and geochemical studies suggest that the Early to Middle Devonian-shelf-margin basins may have been fault-bound and controlled by inherited Precambrian structure. Subsequently, the migrating latest Middle to Late Devonian Antler orogenic forebulge exerted a dominant control on shelf-margin position, morphology, and sedimentation. ??Geological Society of

  8. Margin Evaluation in the Presence of Deformation, Rotation, and Translation in Prostate and Entire Seminal Vesicle Irradiation With Daily Marker-Based Setup Corrections

    Energy Technology Data Exchange (ETDEWEB)

    Mutanga, Theodore F., E-mail: [Division of Medical Physics, Department of Radiation Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Boer, Hans C.J. de [Division of Medical Physics, Department of Radiation Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Wielen, Gerard J. van der [Department of Radiation Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Hoogeman, Mischa S. [Division of Medical Physics, Department of Radiation Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Incrocci, Luca [Department of Radiation Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Heijmen, Ben J.M. [Division of Medical Physics, Department of Radiation Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam (Netherlands)


    Purpose: To develop a method for margin evaluation accounting for all measured displacements during treatment of prostate cancer. Methods and Materials: For 21 patients treated with stereographic targeting marker-based online translation corrections, dose distributions with varying margins and gradients were created. Sets of possible cumulative delivered dose distributions were simulated by moving voxels and accumulating dose per voxel. Voxel motion was simulated consistent with measured distributions of systematic and random displacements due to stereographic targeting inaccuracies, deformation, rotation, and intrafraction motion. The method of simulation maintained measured correlation of voxel motions due to organ deformation. Results: For the clinical target volume including prostate and seminal vesicles (SV), the probability that some part receives <95% of the prescribed dose, the changes in minimum dose, and volume receiving 95% of prescription dose compared with planning were 80.5% {+-} 19.2%, 9.0 {+-} 6.8 Gy, and 3.0% {+-} 3.7%, respectively, for the smallest studied margins (3 mm prostate, 5 mm SV) and steepest dose gradients. Corresponding values for largest margins (5 mm prostate, 8 mm SV) with a clinical intensity-modulated radiotherapy dose distribution were 46.5% {+-} 34.7%, 6.7 {+-} 5.8 Gy, and 1.6% {+-} 2.3%. For prostate-only clinical target volume, the values were 51.8% {+-} 17.7%, 3.3 {+-} 1.6 Gy, and 0.6% {+-} 0.5% with the smallest margins and 5.2% {+-} 7.4%, 1.8 {+-} 0.9 Gy, and 0.1% {+-} 0.1% for the largest margins. Addition of three-dimensional rotation corrections only improved these values slightly. All rectal planning constraints were met in the actual reconstructed doses for all studied margins. Conclusion: We developed a system for margin validation in the presence of deformations. In our population, a 5-mm margin provided sufficient dosimetric coverage for the prostate. In contrast, an 8-mm SV margin was still insufficient owing to

  9. Energy system analysis of marginal electricity supply in consequential LCA

    DEFF Research Database (Denmark)

    Lund, Henrik; Mathiesen, Brian Vad; Christensen, Per


    Background, aim and scope This paper discusses the identification of the environmental consequences of marginal electricity supplies in consequential life cycle assessments (LCA). According to the methodology, environmental characteristics can be examined by identifying affected activities, i...... evaluation of the environmental consequences. Recommendations and perspectives This paper recommends a combination of LCA and ESA as a methodology for identifying a complex set of marginal technologies. The paper also establishes values for Danish marginal electricity production as a yearly average (YAM......) that can be used in future LCA studies involving Danish electricity....

  10. Whole-brain hippocampal sparing radiation therapy: Volume-modulated arc therapy vs intensity-modulated radiation therapy case study

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Katrina, E-mail:; Lenards, Nishele; Holson, Janice


    The hippocampus is responsible for memory and cognitive function. An ongoing phase II clinical trial suggests that sparing dose to the hippocampus during whole-brain radiation therapy can help preserve a patient's neurocognitive function. Progressive research and advancements in treatment techniques have made treatment planning more sophisticated but beneficial for patients undergoing treatment. The aim of this study is to evaluate and compare hippocampal sparing whole-brain (HS-WB) radiation therapy treatment planning techniques using volume-modulated arc therapy (VMAT) and intensity-modulated radiation therapy (IMRT). We randomly selected 3 patients to compare different treatment techniques that could be used for reducing dose to the hippocampal region. We created 2 treatment plans, a VMAT and an IMRT, from each patient's data set and planned on the Eclipse 11.0 treatment planning system (TPS). A total of 6 plans (3 IMRT and 3 VMAT) were created and evaluated for this case study. The physician contoured the hippocampus as per the Radiation Therapy Oncology Group (RTOG) 0933 protocol atlas. The organs at risk (OR) were contoured and evaluated for the plan comparison, which included the spinal cord, optic chiasm, the right and left eyes, lenses, and optic nerves. Both treatment plans produced adequate coverage on the planning target volume (PTV) while significantly reducing dose to the hippocampal region. The VMAT treatment plans produced a more homogenous dose distribution throughout the PTV while decreasing the maximum point dose to the target. However, both treatment techniques demonstrated hippocampal sparing when irradiating the whole brain.

  11. Biodiversity and agro-ecology in field margins. (United States)

    De Cauwer, B; Reheul, D; Nijs, I; Milbau, A


    This multidisciplinary study investigates agro-ecological functions (nature conservation, agriculture, environment) and implications of newly created, mown sown and unsown field margin strips installed on ex-arable land to increase biodiversity. From conservational concern, the development of species rich field margin strips was not strongly affected by the installed type of margin strip since species diversity converged over time, whether strips were sown or not. Convergence between unsown and sown margin strips occurred also in terms of species composition: unsown and sown strips became similar over time. Mowing without removal of cuttings significantly reduced species richness, yielded more grassy margin strips and delayed similarity in species composition between sown and unsown margin strips. Species richness on the longer term was not significantly affected by light regime nor by disturbance despite significant temporary effects shortly after the disturbance event. On the contrary vegetation composition in terms of importance of functional groups changed after disturbance: the share of spontaneous species within functional groups increased resulting in higher similarity between the sown and unsown vegetation. Furthermore risk of invasion was highest in the disturbed unsown community on the unshaded side of a tree lane. A positive effect of botanical diversity on insect number and diversity was found. However the effects of botanical diversity on insect number was mediated by light regime. At high light availability differences between plant communities were more pronounced compared to low light availablilty. The abundance of some insect families was dependent on the vegetation composition. Furthermore light availability significantly influenced insect diversity as well as the spatial distribution of families. From agricultural concern, installing margin strips by sowing a species mixture and a mowing regime with removal of cuttings are good practices to

  12. Ovarian volume throughout life

    DEFF Research Database (Denmark)

    Kelsey, Thomas W; Dodwell, Sarah K; Wilkinson, A Graham


    cancer. To date there is no normative model of ovarian volume throughout life. By searching the published literature for ovarian volume in healthy females, and using our own data from multiple sources (combined n=59,994) we have generated and robustly validated the first model of ovarian volume from...... to about 2.8 mL (95% CI 2.7-2.9 mL) at the menopause and smaller volumes thereafter. Our model allows us to generate normal values and ranges for ovarian volume throughout life. This is the first validated normative model of ovarian volume from conception to old age; it will be of use in the diagnosis...

  13. Drilling in Current-Controlled Sedimentary Environments on the Southeast African Margin - The SAFARI Pre-Site Survey Challenges on the Madagascar, Mozambique and the South African Margin (United States)

    Spiess, V.; Preu, B.; Schwenk, T.; Palamenghi, L.; Schneider, R.; Zahn, R.; Hall, I.


    As part of the global conveyer belt circulation, the Agulhas, Mozambique and Madagascar Currents are guided southward along the Southeast African margin as strong contour currents, affecting local sediment mobilization, redistribution and deposition. To gain a better understanding of their evolution through time, a transect of drill sites ranging from the southern tip of Africa to Madagascar was proposed by Zahn et al. (SAFARI, IODP proposal 702). As contour currents become erosive in their vicinity, deposition may be inhibited and incoming sediment will be redistributed. To find suitable drill sites, they must be positioned strategically to provide continuous depositional records on the one hand by not not being located in the core of the current, and to record variations in current activity and strength, which requires a certain proximity to the mean current position. Furthermore, sources of sediment and their spatial and temporal variability play a role for the interpretation of accumulation rates, provenance of particles, reconstruction of current velocities and terrestrial input, which can be compared as climate indicators with marine geochemical tracers. Six different working areas, West of Capetown, Natal Valley, Limpopo Cone, Zambezi margin, Davie Ridge and N-Madagascar margin, were visited during R/V Meteor Cruises M63/1 (2005) and M75/3 (2008) to gain an understanding of sediment deposition and to select sites for the drilling proposal. Main observations of both cruises were, in contrast to the expectation of margins being predominantly shaped by fan deposition and mass wasting processes, the widespread occurrences of large scales contourite bodies, which were situated between 100 and 1500 m water depth. They appear to be independent of the mechanisms and volume of sediment input, revealing a close relationship to the acting contour currents. Accordingly, the drift bodies appear to be suitable deposits which record the activity of the currents by

  14. Rare Posterior Pharyngeal Mass: Atypical Marginal Zone Hyperplasia. (United States)

    Eliçora, Sultan Şevik; Güven, Mehmet; Varli, Ali F; Yilmaz, Mahmut S; Alponat, Selin


    Cases of posterior pharyngeal masses are quite rare, and are typically derived from schwannoma or encephalocele, or are of vascular or infectious origin. They are clinically significant due to their tendency to cause airway obstruction. The aim of this study was to present a rare atypical marginal hyperplasia case of a posterior pharyngeal wall mass. A 10-year-old male was admitted to our clinic with dyspnea. A plane-surfaced 4 × 3 × 3 cm mass was observed on the posterior pharyngeal wall upon physical examination. The patient underwent magnetic resonance imaging and surgical treatment. Following excision of material from the patient's mass, a pathologic diagnosis of atypical marginal zone hyperplasia was made. Atypical marginal zone hyperplasia of the posterior pharyngeal wall has not yet been reported in the literature. Marginal zone hyperplasia associated with a lymphoproliferative disease should be considered when making differential diagnoses of posterior pharyngeal wall masses.

  15. Stochastic margin-based structure learning of Bayesian network classifiers. (United States)

    Pernkopf, Franz; Wohlmayr, Michael


    The margin criterion for parameter learning in graphical models gained significant impact over the last years. We use the maximum margin score for discriminatively optimizing the structure of Bayesian network classifiers. Furthermore, greedy hill-climbing and simulated annealing search heuristics are applied to determine the classifier structures. In the experiments, we demonstrate the advantages of maximum margin optimized Bayesian network structures in terms of classification performance compared to traditionally used discriminative structure learning methods. Stochastic simulated annealing requires less score evaluations than greedy heuristics. Additionally, we compare generative and discriminative parameter learning on both generatively and discriminatively structured Bayesian network classifiers. Margin-optimized Bayesian network classifiers achieve similar classification performance as support vector machines. Moreover, missing feature values during classification can be handled by discriminatively optimized Bayesian network classifiers, a case where purely discriminative classifiers usually require mechanisms to complete unknown feature values in the data first.

  16. Marginal revenue and length of stay in inpatient psychiatry. (United States)

    Pletscher, Mark


    This study examines the changes in marginal revenue during psychiatric inpatient stays in a large Swiss psychiatric hospital after the introduction of a mixed reimbursement system with tariff rates that vary over length of stay. A discrete time duration model with a difference-in-difference specification and time-varying coefficients is estimated to assess variations in policy effects over length of stay. Among patients whose costs are fully reimbursed by the mixed scheme, the model demonstrates a significant effect of marginal revenue on length of stay. No significant policy effects are found among patients for whom only health insurance rates are delivered as mixed tariffs and government contributions are made retrospectively. The results indicate that marginal revenue can affect length of stay in inpatient psychiatry facilities, but that the reduction in marginal revenue must be sufficiently large.

  17. Slumping on the western continental margin of India

    Digital Repository Service at National Institute of Oceanography (India)

    Guptha, M.V.S.; Mohan, R.; Muralinath, A.S.

    A short gravity core from the Western Continental Margin of India has been examined to understand the nature and characteristics of slumping in the area. The present study and also the earlier studies revealed that the slumping on the western...

  18. Extranodal marginal zone (MALT) lymphoma in common variable immunodeficiency.

    NARCIS (Netherlands)

    Desar, I.M.; Keuter, M.; Raemaekers, J.M.M.; Jansen, J.B.M.J.; Krieken, J.H.J.M. van; Meer, J.W.M. van der


    We describe two patients with common variable immunodeficiency (CVID) who developed extranodal marginal zone lymphoma (formerly described as mucosa-associated lymphoid tissue lymphoma or MALT lymphoma). One patient, with documented pernicious anaemia and chronic atrophic gastritis with metaplasia, d

  19. The Paleoecology of Vegetation on Pennsylvanian Basin Margins

    DEFF Research Database (Denmark)

    Bashforth, Arden Roy

    on a fluvial megafan under strongly seasonal conditions, gigantic cordaitalean forests dominated the landscape, particularly alongside ephemeral channels.  Floodplains were largely dry and degraded, although pteridosperms, ferns, and lycopsids persisted around poorly drained depressions.  On the Nýrany Member...... braided-river plain (Middle Pennsylvanian, Central and Western Bohemian Basin, Czech Republic), raised channel margins supported long-lived site-occupiers, such as cordaitaleans and pteridosperms.  Pioneering vegetation comprising fast-growing, opportunistic taxa, particularly ferns and sphenopsids......, was common on wetter, shifting substrates of frequently flooded abandoned channels, low-lying floodplains, and lake margins.  In La Magdalena Coalfield (Late Pennsylvanian, Spain), pteridosperms dominated marginal wetlands adjacent to steep basin margins.  Opportunistic ferns were abundant in or adjacent...

  20. Comparative biogeochemistry–ecosystem–human interactions on dynamic continental margins..

    Digital Repository Service at National Institute of Oceanography (India)

    Levin, L.A.; Liu, K-K.; Emeis, K.-C.; Breitburg, D.L.; Cloern, J.; Deutsch, C.; Giani, M.; Goffart, A.; Hofmann, E.E.; Lachkar, Z.; Limburg, K.; Liu, Su-Mei; Montes, E.; Naqvi, S.W.A.; Ragueneau, O.; Rabouille, C.; Sarkar, S.K.; Swaney, D.P.; Wassman, P.; Wishner, K.F.

    The oceans' continental margins face strong and rapid change, forced by a combination of direct human activity, anthropogenic CO2-induced climate change, and natural variability. Stimulated by discussions in Goa, India at the IMBER IMBIZO III, we (1...

  1. U.S. East Coast Continental Margin (CONMAR) Sediment Data (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The USGS/WHOI Continental Margin (CONMAR) Data set was compiled by the U.S. Geological Survey and the Woods Hole Oceanographic Institution as a joint program of...

  2. Total Sediment Thickness of the World's Oceans & Marginal Seas (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A digital total-sediment-thickness database for the world's oceans and marginal seas has been compiled by the NOAA National Geophysical Data Center (NGDC). The data...

  3. Lead poisoning and marginalization in newborns of Morelos, Mexico

    National Research Council Canada - National Science Library

    Martha María Téllez-Rojo; Luis F Bautista-Arredondo; Vesta Richardson; Daniel Estrada-Sánchez; Laura Ávila-Jiménez; Camilo Ríos; Alejandra Cantoral-Preciado; Martín Romero-Martínez; Delia Flores-Pimentel; Maria del Carmen Melo-Zurita; Anita Romero-Ramírez; Marco Antonio León-Mazón; Sergio Montes; Richard Fuller; Mauricio Hernández-Avila


    Objective. To determine the prevalence of lead (Pb) poi- soning at birth in Morelos, analyze its distribution by social marginalization level, and estimate the association with the use of lead glazed ceramics (LGC...

  4. Russula herrerae, a new species with marginal veil from Mexico. (United States)

    Kong, Alejandro; Montoya, Adriana; Estrada-Torres, Arturo


    Russula herrerae, a new species belonging to section Plorantes, subsection Lactarioideae, characterized by the presence of a marginal veil and collected in a temperate Quercus forest in Tlaxcala, Mexico, is described and illustrated.

  5. The marginal social cost of headway for a scheduled service

    DEFF Research Database (Denmark)

    Fosgerau, Mogens


    waiting time costs as well as schedule delay costs measured relative to their desired time of arrival at the destination. They may either arrive at the station to choose just the next departure or they may plan for a specific departure in which case they incur also a planning cost. Then planning......This brief paper derives the marginal social cost of headway for a scheduled service, i.e. the cost for users of marginal increases to the time interval between departures. In brief we may call it the value of headway in analogy with the value of travel time and the value of reliability. Users have...... for a specific departure is costly but becomes more attractive at longer headways. Simple expressions for the user cost result. In particular, the marginal cost of headway is large at short headways and smaller at long headways. The difference in marginal costs is the value of time multiplied by half the headway....

  6. Multilevel random effect and marginal models for longitudinal data ...

    African Journals Online (AJOL)

    Multilevel random effect and marginal models for longitudinal data. ... Ethiopian Journal of Science and Technology ... the occurrence of specific adverse events than children injected with licensed vaccine, and if so, to quantify the difference.

  7. Locational marginal prices with SVC in Indian electricity market

    African Journals Online (AJOL)


    real and reactive power has become central issue for better and economic operation of system. .... bilateral contract model used in this paper is basically a subset of the full ...... Wheeling rates of reactive flow under marginal cost theory.

  8. The effect of exchange rate on marketing margin

    Directory of Open Access Journals (Sweden)

    Leila Torki


    Full Text Available This study presents a new structural model that incorprates price linkage and marketing marketing margin identity into a common framework. The inclusiom of exchange rate expands the framework to include goods traded in different currencies. This allows emprical estimates to be made of how changes in domestic prices exchange rates and middlemen costs are transmitted to foreign prices and the international marketing margin. The framework is emprically applied to international marketing channel using farmed apple data to investigate how Iranian export prices exchange rates and middlemen costs affect turkey wholesale prices and the marketing margin. Results suggest that the markets are via complete price and exchange rate pass through purely competitive and that the marketing margin only increase when costs of marketing service increase.

  9. Quaternary alluvial stratigraphy and palaeoclimatic reconstruction at the Thar margin

    DEFF Research Database (Denmark)

    Jain, M.; Tandon, S.K.


    Quaternary alluvial record at the Thar desert margin has been examined using the exposed succession along Mahudi, Sabarmati river, Western India. Different alluvial facies, their associations and granulometry have been studied for palaeoenvironmental reconstruction. Clay mineral indices smectite/...

  10. Crustal thinning and tectonic geomorphology: redefining the passive margin (United States)

    Redfield, T.; Osmundsen, P. T.


    We describe Scandinavia's passive margin in terms of a hyper-extended distal margin, a variably tapered proximal margin that includes the outer onshore areas, and an upwarped, unstretched, continent-sloping hinterland that terminates against the "undeformed" cratonic interior. Two benchmark locations, defined as the taper break (TB) and the Hinterland Break in Slope (HBSL), occur at the inner boundary of the distal margin and at the transition from the continent-sloping hinterland and craton, respectively. The elevation of the seaward-facing escarpment is directly scaled to the distance between the taper break and the Hinterland Break in Slope. Scaling relationships between the taper of the crystalline crust in the direction of the distal margin and the length/dip of the hinterland backslope follow directly. The shape factors of major catchments are directly scaled to the taper of the proximal margin and drainage azimuths are parallel to the mean transport lineation recorded from a distinct population of range-bounding normal faults. Topographic expressions of the footwalls and offsets in apatite fission-track age-patterns indicate that fault movement controlled topography, locally and regionally inboard of sharp crustal tapers long after the main phase of crustal thinning. We extend our definition of the passive margin to other post-breakup margins. One particularly fine example is SE Brasil. New data (Zalan et al., 2011) suggest the direct correlation of SE Brasil's Taper Break with its escarpment elevation in a manner consistent with our Scandinavian and global observations. The Taper Hypothesis appears to hold across old and young, glaciated, and unglaciated margins. Following the stretching, thinning, and exhumation phase, an "accommodation phase" is warranted. During accommodation, the initially elevated escarpments can be eroded to very low base levels and subsequently undergo inboard rejuvenation by footwall uplift, in response to tensile stresses

  11. Mean nuclear volume

    DEFF Research Database (Denmark)

    Mogensen, O.; Sørensen, Flemming Brandt; Bichel, P.


    We evaluated the following nine parameters with respect to their prognostic value in females with endometrial cancer: four stereologic parameters [mean nuclear volume (MNV), nuclear volume fraction, nuclear index and mitotic index], the immunohistochemical expression of cancer antigen (CA125...

  12. Australia's southern margin: a product of oblique extension (United States)

    Willcox, J. B.; Stagg, H. M. J.


    Recently developed detachment models of continental margin formation interpret the southern margin of Australia to have formed when the lower-plate Australian margin was pulled out from beneath the upper-plate Antarctic margin. Data now available and summarised in this paper, point very strongly to a generally NW-SE direction of initial continental extension for the southern margin, in contrast to the widely held picture of simple N-S rifting. The evidence for this extension direction comes from the analysis of deep Seismic data acquired by the Bureau of Mineral Resources in 1986 in the central Great Australian Bight (GAB), the gravity field of the GAB, Seismic and magnetic basement structures in the Eyre Sub-basin, Polda Trough, Ceduna Depocentre and Duntroon Basin and from the analysis of the magnetic seafloor spreading anomalies produced during the slow first phase of drifting between Australia and Antarctica. Further, it is now believed that the formation of the southern margin of Australia can be described in terms of three phases of continental extension (El to E3) and two phases of drifting (D1 and D2). In summary, these phases were as follows. E1: approximately 300 km of Late Jurassic (?or older) to Early Cretaceous NW-SE-oriented extension in the GAB, with strike-slip motion in the nascent Otway Basin and along the Tasmanian margin. E2: 120 km of Early Cretaceous NNE-SSW-oriented extension which formed the basins of southeastern Australia (Otway, Bass, Gippsland) and which probably produced a structural overprinting in the GAB Basin. E3/D1: minor continental extension and the first 500 km of slow drift between Australia and Antarctica on an azimuth of 165°; wrenching on the Tasmanian margin. D2: 2600 km of fast drifting between Australia and Antarctica on a N-S azimuth.

  13. The origin of marginal zone B cells in the rat

    NARCIS (Netherlands)

    Dammers, PM; de Boer, NK; Deenen, GJ; Nieuwenhuis, P; Kroese, FGM


    The marginal zone is a unique compartment that is only found in the spleen. Rat marginal zone B cells (MZ-B) can be distinguished from other B cells, e.g. recirculating follicular B cells (RF-B), by several phenotypic characteristics. Typically MZ-B cells are surface (s)IgM(hi), sIgD(lo) and CD45R(B

  14. Analysis of Marketing Margins in Eco-Labeled Products


    Carambas, Maria Cristina D.M.


    This article aims to explain the marketing margins in the eco-labeled products market in Thailand and the Philippines. It focuses on labeled organic agricultural commodities that are commonly exported especially in Europe, which has demand for this type of products. Understanding the interplay of economic variables influencing marketing margins in the eco-labeled market as compared to its conventional counterpart is relevant in understanding how this growing niche market works. The analytical...

  15. The marginal benefit of diversification in commercial real estate portfolios


    Lee, Stephen L.


    The number of properties to hold to achieve a well-diversified real estate property portfolio presents a puzzle, as the estimated number is considerably higher than that seen in actual portfolios. However, Statman (1987) argues that investors should only increase the number of holdings as long as the marginal benefits of diversification exceed their costs. Using this idea we find that the marginal benefits of diversification in real estate portfolios are so small that investors are probably r...

  16. Mud-dominated basin margin progradation: processes and implications


    Poyatos-Moré, M; Jones, GD; Brunt, RL; Hodgson, DM; Wild, RJ; Flint, SS


    The accretion of coarse-grained material at the shelf-edge rollover has been emphasized in studies of basin margin progradation, despite fine grained sediment (clay and silt) representing a volumetrically more significant component of subaqueous clinothems. The timing and processes of fine-grained sediment transport across the shelf and onto the slope remains an understudied facet of sedimentary basin stratigraphy. Three exhumed basin margin-scale clinothems of the Permian Waterford Formation...

  17. The effect of exchange rate on marketing margin


    Leila Torki; AhmadAli Rezaei; Shekofeh Nagheli


    This study presents a new structural model that incorprates price linkage and marketing marketing margin identity into a common framework. The inclusiom of exchange rate expands the framework to include goods traded in different currencies. This allows emprical estimates to be made of how changes in domestic prices exchange rates and middlemen costs are transmitted to foreign prices and the international marketing margin. The framework is emprically applied to international marketing channel ...

  18. The East Greenland rifted volcanic margin

    Directory of Open Access Journals (Sweden)

    C. Kent Brooks


    Full Text Available The Palaeogene North Atlantic Igneous Province is among the largest igneous provinces in the world and this review of the East Greenland sector includes large amounts of information amassed since previous reviews around 1990.The main area of igneous rocks extends from Kangerlussuaq (c. 67°N to Scoresby Sund (c. 70°N, where basalts extend over c. 65 000 km2, with a second area from Hold with Hope (c. 73°N to Shannon (c. 75°N. In addition, the Ocean Drilling Project penetrated basalt at five sites off South-East Greenland. Up to 7 km thickness of basaltic lavas have been stratigraphically and chemically described and their ages determined. A wide spectrum of intrusions are clustered around Kangerlussuaq, Kialeeq (c. 66°N and Mesters Vig (c. 72°N. Layered gabbros are numerous (e.g. the Skaergaard and Kap Edvard Holm intrusions, as are under- and oversaturated syenites, besides small amounts of nephelinite-derived products, such as the Gardiner complex (c. 69°N with carbonatites and silicate rocks rich in melilite, perovskite etc. Felsic extrusive rocks are sparse. A single, sanidine-bearing tuff found over an extensive area of the North Atlantic is thought to be sourced from the Gardiner complex.The province is famous for its coast-parallel dyke swarm, analogous to the sheeted dyke swarm of ophiolites, its associated coastal flexure, and many other dyke swarms, commonly related to central intrusive complexes as in Iceland. The dyke swarms provide time markers, tracers of magmatic evolution and evidence of extensional events. A set of dykes with harzburgite nodules gives unique insight into the Archaean subcontinental lithosphere.Radiometric dating indicates extrusion of huge volumes of basalt over a short time interval, but the overall life of the province was prolonged, beginning with basaltic magmas at c. 60 Ma and continuing to the quartz porphyry stock at Malmbjerg (c. 72°N at c. 26 Ma. Indeed, activity was renewed in the Miocene with

  19. Large margin classification with indefinite similarities

    KAUST Repository

    Alabdulmohsin, Ibrahim


    Classification with indefinite similarities has attracted attention in the machine learning community. This is partly due to the fact that many similarity functions that arise in practice are not symmetric positive semidefinite, i.e. the Mercer condition is not satisfied, or the Mercer condition is difficult to verify. Examples of such indefinite similarities in machine learning applications are ample including, for instance, the BLAST similarity score between protein sequences, human-judged similarities between concepts and words, and the tangent distance or the shape matching distance in computer vision. Nevertheless, previous works on classification with indefinite similarities are not fully satisfactory. They have either introduced sources of inconsistency in handling past and future examples using kernel approximation, settled for local-minimum solutions using non-convex optimization, or produced non-sparse solutions by learning in Krein spaces. Despite the large volume of research devoted to this subject lately, we demonstrate in this paper how an old idea, namely the 1-norm support vector machine (SVM) proposed more than 15 years ago, has several advantages over more recent work. In particular, the 1-norm SVM method is conceptually simpler, which makes it easier to implement and maintain. It is competitive, if not superior to, all other methods in terms of predictive accuracy. Moreover, it produces solutions that are often sparser than more recent methods by several orders of magnitude. In addition, we provide various theoretical justifications by relating 1-norm SVM to well-established learning algorithms such as neural networks, SVM, and nearest neighbor classifiers. Finally, we conduct a thorough experimental evaluation, which reveals that the evidence in favor of 1-norm SVM is statistically significant.

  20. Certifiable higher order sliding mode control: Practical stability margins approach (United States)

    Panathula, Chandrasekhara Bharath

    The Higher Order Sliding Mode (HOSM) controllers are well known for their robustness/insensitivity to bounded perturbations and for handling any given arbitrary relative degree system. The HOSM controller is to be certified for robustness to unmodeled dynamics, before deploying the controller for practical applications. Phase Margin (PM) and Gain Margin ( GM) are the classical characteristics used in linear systems to quantify the linear controller robustness to unmodeled dynamics, and certain values of these margins are required to certify the controller. These conventional margins (PM and GM) are extended to Practical Stability Phase Margin (PSPM) and Practical Stability Gain Margin (PSGM) in this dissertation, and are used to quantify the HOSM control robustness to unmodeled dynamics, presiding the tool to close the gap for HOSM control certification. The proposed robustness metrics ( PSPM and PSGM) are identified by developing tools/algorithms based on Describing Function-Harmonic Balance method. In order for the HOSM controller to achieve the prescribed values on robustness metrics ( PSPM and PSGM), the HOSM controller is cascaded with a linear compensator. A case study of the application of the proposed metrics (PSPM and PSGM) for the certification of F-16 aircraft HOSM attitude control robustness to cascade unmodeled dynamics is presented. In addition, several simulation examples are presented to verify and to validate the proposed methodology.

  1. The evolution and evolutionary consequences of marginal thermostability in proteins. (United States)

    Goldstein, Richard A


    When we seek to explain the characteristics of living systems in their evolutionary context, we are often interested in understanding how and why certain properties arose through evolution, and how these properties then affected the continuing evolutionary process. This endeavor has been assisted by the use of simple computational models that have properties characteristic of natural living systems but allow simulations over evolutionary timescales with full transparency. We examine a model of the evolution of a gene under selective pressure to code for a protein that exists in a prespecified folded state at a given growth temperature. We observe the emergence of proteins with modest stabilities far below those possible with the model, with a denaturation temperature tracking the simulation temperature, despite the absence of selective pressure for such marginal stability. This demonstrates that neither observations of marginally stable proteins, nor even instances where increased stability interferes with function, provide evidence that marginal stability is an adaptation. Instead the marginal stability is the result of a balance between predominantly destabilizing mutations and selection that shifts depending on effective population size. Even if marginal stability is not an adaptation, the natural tendency of proteins toward marginal stability, and the range of stabilities that occur during evolution, may have significant effect on the evolutionary process.

  2. Disability and marginal utility of income: evidence from hypothetical choices. (United States)

    Tengstam, Sven


    It is often assumed that disability reduces the marginal utility of income. In this article, individuals' marginal utility of income in two states-(i) paralyzed in both legs from birth and (ii) not mobility impaired at all-is measured through hypothetical choices between imagined lotteries behind a so-called veil of ignorance. The outcomes of the lotteries include both income and disability status. It is found that most people have higher marginal utility when paralyzed than when not mobility impaired at all. The two marginal utilities are evaluated at the same levels of income. Having personal experience of mobility impairment and supporting the Left Party, the Social Democratic Party, the Green Party, or the Liberal Party are associated with having a higher marginal utility when paralyzed. The results suggest that more than full insurance of income losses connected to being disabled is optimal. The results further suggest that, given a utilitarian social welfare function, resources should be transferred to rather than from disabled people. Finally, if the transfers are not large enough to smooth out the marginal utilities of the disabled and the nondisabled, distributional weights based on disability status should be used in cost-benefit analysis.

  3. Comparison of flank margin cave development on San Salvador island, Bahamas, and Isla de Mona, Puerto Rico (United States)

    Mylroie, J.; Carew, J.L.; Frank, E.F.; Larsen, Matthew C.; Boardman, M.


    San Salvador Island, Bahamas is a 161 Km2 tectonically stable late Quaternary carbonate island located 600 km east-southeast of Miami FL. San Salvador contains numerous flank margin caves (phreatic karst features) that developed primarily in late Pleistocene eolianites. These caves developed during a short time in versy small fresh-water lenses. Cave elevations and Uranium-series ages from stalagmites indicate that all currently subaerial flank margin caves developed during the last interglacial seal-level highstand that was 6 m above current mean seal level 125,000 years ago (oxygen isotope substage 5e), which lasted no more than 14,000 years. The caves were formed by dissolution in the mixing zone at the margin of a freshwater lens that was elevated by the substage 5e highstand, and which resided within the small emergent portions of eolianite ridges. The flank margin caves have chambers with volumes greater than 1000 m3 on San Salvador; on other Bahamian islands, chambers as large as 14,000 m3 are known.

  4. Characteristics and features of the submarine landslides in passive and active margin southwestern offshore Taiwan (United States)

    Yeh, Y. C.


    In the past decade, numerous multi-channel seismic surveys as well as near seafloor high resolution geophysical investigations were conducted in order to explore and estimate the reserves of gas hydrate southwestern offshore Taiwan. The previous object was focused on searching substitute energy (i.e. gas hydrate) rather than geo-hazards. However, it is suggested that most of the gas hydrate is generally distributed at slope area southwestern offshore Taiwan, which indicates the slope may be failed when steady state was disturbed by some factors, such as sea level or climate change. In addition, once gas hydrate was dissociated, this may induce submarine landslide that further cause devastated tsunami. Thus, it is of great urgency to investigate potential landslide area, particularly, the hydrate-rich continental slope (active and passive margins) in adjacent to populous city like Kaohsiung. In this study, we collected several high resolution multi-channel seismic data with ten seconds shooting rate and 3.125 meters group interval streamer by using R/V ORI and R/V ORV. The seismic data were processed in conventional data processing strategy: bad trace clean, geometry settings, band-pass filter, de-convolution, surface-related multiple rejection, radon filter, stacking,kirchhoff migration and time to depth conversion. Combine the results obtained from the MCS data and subbottom profiles, two major results could be raised in the active margin as followed: (1) Most of the surface creeping and landslide was occurred shallower than 500 meters in water depth, which should be related to the inter-bedded fluid activities. (2) The landslide distribution is lagly affected by the presence of diaper, suggesting the subsequent mud diapirism may destruct slope stability; (3) The submarine landslide deeper than 800 meters in water depth distributes in the thrust fold area, that is probably referred to active thrusting. In the passive margin, large volume mass transportation

  5. Correlation of Magnetic Resonance Imaging Tumor Volume with Histopathology (United States)

    Turkbey, Baris; Mani, Haresh; Aras, Omer; Rastinehad, Ardeshir R.; Shah, Vijay; Bernardo, Marcelino; Pohida, Thomas; Daar, Dagane; Benjamin, Compton; McKinney, Yolanda L.; Linehan, W. Marston; Wood, Bradford J.; Merino, Maria J.; Choyke, Peter L.; Pinto, Peter A.


    .02), respectively. Similar results were found in the analysis with shrinkage factor corrected tumor volumes at histopathology. Conclusions Magnetic resonance imaging can accurately estimate index tumor volume as determined by histology. Magnetic resonance imaging has better accuracy in predicting histopathology tumor volume in tumors larger than 0.5 cm3 than prostate specific antigen and age. Index tumor volume as determined by magnetic resonance imaging may be helpful in planning treatment, specifically in identifying tumor margins for image guided focal therapy and possibly selecting better active surveillance candidates. PMID:22901591

  6. Marginal integrity of class V restorations: SEM versus dye penetration. (United States)

    Ernst, Claus-Peter; Galler, Pia; Willershausen, Brita; Haller, Bernd


    To perform an in vitro investigation on the marginal integrity of different adhesives (Optibond FL, Scotchbond 1XT, Clearfil SE Bond, Adper Prompt L-Pop, S(3) Bond, iBond exp., Adper Prompt L-Pop) in combination with Tetric Ceram as well as an experimental silorane-restorative (Hermes, Hermes Bond; 3M ESPE) using SEM and dye penetration (2% methylene blue) in a comparative manner. Standardized class V-cavities (3 mm x 1.5 mm) were prepared in 70 extracted human teeth (n=10). The adhesives were applied according to manufacturers' instructions. The cavities were restored with three increments. After finishing and polishing (Sof-Lex discs) and thermocycling (5000x, 5/55 degrees C), replicas were taken and the teeth immersed in the dye for 10s (D10) and evaluated. After another penetration of 30 min (D30) a final evaluation of the percentage of dye-penetrated margins was conducted. The median percentages in marginal gaps (%) at the enamel margins for the three methods investigated (D10/D30/SEM) were--Optibond FL: 0/0/4, Scotchbond 1 XT: 5/16/11, Clearfil SE Bond: 0/0/0, S(3) Bond: 0/0/1, iBond exp.: 20/42/12, Adper Prompt L-Pop: 5/23/8, Hermes/Hermes Bond: 5/45/24. Cementum margins--Optibond FL: 0/1/0, Scotchbond 1 XT: 0/21/23, Clearfil SE Bond: 0/0/4, S(3) Bond: 0/0/0, iBond exp.: 0/0/0, Adper Prompt L-Pop: 10/32/23, Hermes/Hermes Bond: 0/0/13. After pooling the data of all groups, a Spearmann's rho test showed a good correlation between the methods D10 and D30 at the enamel margins and at the entire cavity margins (correlation coefficient 0.8 and 0.7). SEM did not correlate with the results obtained from D10 (correlation coefficient <0.5). A fair correlation was found between SEM and D30 for the entire cavity margin but a good correlation for the enamel margins. No correlation between investigation methods was determined at the cementum margins. D30 showed a better correlation to SEM than D10 did. Therefore, 30 min of dye penetration time seems to be more suitable

  7. Lumpectomy cavity shaved margins do not impact re-excision rates in breast cancer patients. (United States)

    Coopey, Suzanne B; Buckley, Julliette M; Smith, Barbara L; Hughes, Kevin S; Gadd, Michele A; Specht, Michelle C


    The benefits of taking shaved cavity margins (SCM) at the time of lumpectomy are unclear. We sought to determine if taking SCM decreases re-excision rates by increasing the total breast tissue volume excised. We undertook a retrospective review of breast cancer patients who underwent lumpectomy from 2004 to 2006. Patients were divided into three groups. Group 1 had lumpectomy alone, group 2 had lumpectomy plus select (1-3) SCM, and group 3 had lumpectomy plus complete (≥4) SCM. Pathologic findings and surgical outcomes were compared between groups. 773 cancers treated by lumpectomy were included in this study; 197 were in group 1, 130 were in group 2, and 446 were in group 3. The mean total volume of breast tissue excised in group 1 (106.6 cm(3)) was significantly larger than the volume excised in groups 2 (79.3 cm(3)) and 3 (76.3 cm(3)). Rates of re-excision and successful breast-conservation therapy (BCT) were not significantly different between groups. Despite a lower total volume of breast tissue excised in groups 2 and 3, there was no significant increase in locoregional recurrence rates (LRR) at median follow-up of 54 months. Taking additional SCM during lumpectomy resulted in a significantly lower overall volume of breast tissue excised, with no increase in LRR. Contrary to prior studies, we found that SCM did not decrease re-excision rates or impact the success of BCT. Therefore, the main advantage of taking SCM appears to be that less breast tissue is excised, which could potentially improve cosmetic outcomes.

  8. Comparison of turbidite facies associations in modern passive-margin Mississippi fan with ancient active-margin fans (United States)

    Shanmugam, G.; Moiola, R. J.; McPherson, J. G.; O'Connell, S.


    Our comparison of the modern passive-margin Mississippi fan (DSDP Leg 96) with ancient active-margin fans (e.g. Eocene Hecho Group, Spain) reveals major differences in turbidite facies associations (Mutti and Ricci Lucchi scheme) and in seismic characteristics in the lower fan area. The lower (outer) Mississippi fan is composed of channel (Facies B and F) and non-channel facies (C? and D), whereas ancient fans are characterized by non-channelized, thickening-upward, depositional lobe facies (C and D). An absence of depositional lobes in the lower Mississippi fan is also suggested by a lack of convex-upward (mounded) seismic reflections with bidirectional downlap. Continuous seismic reflections of the lower Mississippi fan may represent "sheet sands", but not those of true depositional lobes with mounded character. Extensive channelization in modern passive-margin fans appears to be a product of the lateral shifting of a major sinuous distributary system, developed as a consequence of low gradients and the transport of sediment with a relatively low sand/mud ratio. In contrast, channels in active-margin fans are short and of low sinuosity as a result of high gradients and the transport of sediment with a relatively high sand/mud ratio. The turbidite facies association scheme, which was developed exclusively from ancient active-margin fans, should be applied to mature passive-margin fans with qualifications because of the differences in spatial distribution of turbidite facies and their associations.

  9. Changes in ice-margin processes and sediment routing during ice-sheet advance across a marginal moraine (United States)

    Knight, P.G.; Jennings, C.E.; Waller, R.I.; Robinson, Z.P.


    Advance of part of the margin of the Greenland ice sheet across a proglacial moraine ridge between 1968 and 2002 caused progressive changes in moraine morphology, basal ice formation, debris release, ice-marginal sediment storage, and sediment transfer to the distal proglacial zone. When the ice margin is behind the moraine, most of the sediment released from the glacier is stored close to the ice margin. As the margin advances across the moraine the potential for ice-proximal sediment storage decreases and distal sediment flux is augmented by reactivation of moraine sediment. For six stages of advance associated with distinctive glacial and sedimentary processes we describe the ice margin, the debris-rich basal ice, debris release from the glacier, sediment routing into the proglacial zone, and geomorphic processes on the moraine. The overtopping of a moraine ridge is a significant glaciological, geomorphological and sedimentological threshold in glacier advance, likely to cause a distinctive pulse in distal sediment accumulation rates that should be taken into account when glacial sediments are interpreted to reconstruct glacier fluctuations. ?? 2007 Swedish Society for Anthropology and Geography.

  10. Assessment of interfractional prostate motion in patients immobilized in the prone position using a thermoplastic shell. (United States)

    Ikeda, Itaru; Mizowaki, Takashi; Sawada, Yohei; Nakata, Manabu; Norihisa, Yoshiki; Ogura, Masakazu; Hiraoka, Masahiro


    The aim of this study was to evaluate the interfractional prostate motion of patients immobilized in the prone position using a thermoplastic shell. A total of 24 patients with prostate calcifications detectable using a kilo-voltage X-ray image-guidance system (ExacTrac X-ray system) were examined. Daily displacements of the calcification within the prostate relative to pelvic bony structures were calculated by the ExacTrac X-ray system. The average displacement and standard deviation (SD) in each of the left-right (LR), anterior-posterior (AP), and superior-inferior (SI) directions were calculated for each patient. Based on the results of interfractional prostate motion, we also calculated planning target volume (PTV) margins using the van Herk formula and examined the validity of the PTV margin of our institute (a 9-mm margin everywhere except posteriorly, where a 6-mm margin was applied). In total, 899 data measurements from 24 patients were obtained. The average prostate displacements ± SD relative to bony structures were 2.8 ± 3.3, -2.0 ± 2.0 and 0.2 ± 0.4 mm, in the SI, AP and LR directions, respectively. The required PTV margins were 9.7, 6.1 and 1.4 mm in the SI, AP and LR directions, respectively. The clinical target volumes of 21 patients (87.5%) were located within the PTV for 90% or more of all treatment sessions. Interfractional prostate motion in the prone position with a thermoplastic shell was equivalent to that reported for the supine position. The PTV margin of our institute is considered appropriate for alignment, based on bony structures.

  11. Definition of the planning target volume of organs at risk (planning organ at risk volume, PRV) in case of radiotherapy of the ORL sphere; Definition d'un volume cible previsionnel d'organe a risque (Planning organ at risk volume, PRV) en cas de radiotherapie de la sphere ORL

    Energy Technology Data Exchange (ETDEWEB)

    Louvel, G.; Le Prise, E.; Williaume, D.; De Crevoisier, R. [Centre Eugene-Marquis, 35 - Rennes (France); Cazoulat, G.; Lafond, C.; Simon, A.; Haigron, P.; De Crevoisier, R. [Universite de Rennes 1 LTSI, 35 - Rennes (France); Inserm U642, 35 - Rennes (France); Li, B.S. [Shandong Cancer Hospital, Jinan (China); Boisselier, P. [Centre Val d' Aurelle, 34 - Montpellier (France)


    The authors report a study which aimed at quantifying anatomic variations of organs at risk and their dosimetric impact, and at computing appropriate margins around organs at risk to generate planning target volumes of organs at risk, representative of the dose delivered to organs at risk. Nine patients have been treated for a locally advanced ORL cancer by a concomitant combination of radiotherapy and chemotherapy, with weekly scanographies during the radiotherapy. Registration has been successfully performed according to three bone references. Volume modifications and motions have been computed to define the margins around three organs at risk. Short communication


    Directory of Open Access Journals (Sweden)

    Ni Made Suciani


    Full Text Available Some schools experienced termerjinalkan circumstances amid the bustle of the city of Denpasar . The problems studied are factors causing some schools experiencing marginalization , how to provide education to marginalized schools , and bagaimanaimplementasinya associated with the five pillars of national education policy and its implications for students , institutions, schools , and masyarakat.Penelitian inimenggunakan qualitative approach . The theory used is the deconstruction theory , structuration theory , and critical education theory . Data was collected using the method of observation , interviews , and documentary techniques , and analyzed qualitatively . The results showed that the appearance of marginalization at some schools due to cultural dualism between public schools and private schools , which includes the views and policies of the government , private sector and the impact of marginality teacher certification . Another factor is the culture , character and public perceptions of the school negeriserta labeling of the marginal private schools , and the lack of financial management and imaging schools to survive for the sake of prestige . In addition there are also technical factors such as the lack of human resource management , lack of competence danusaha - business competence improvement also poor communication and school partnerships with stakeholders , as well as the lack of supervision and evaluation of the achievement of national standards on school education pendidikan.Penyelenggaraan marginalized can be seen from intangible side as diseconomies kumunitas , dehumanization of education and culture in school imaging termarjinalkan.Sedangkan of the tangible results of self-evaluation is through education at school sekolah.Implementasi marginalized related to the five pillars of the national education policy is the availability , affordability , quality , equality and assuredness service besides it also analyzed the

  13. Clinical experience in the use of marginal donor hearts

    Institute of Scientific and Technical Information of China (English)

    XIE Ai-ni; DONG Nian-guo; ZHANG Kai-lun; XIA Jia-hong; XIAO Shi-liang; SUN Zong-quan


    Background Although heart transplantation has become a standard therapy for end-stage heart disease, there are few published studies regarding the use of transplant organs from marginal donors. Here we describe the clinical outcome we have obtained using marginal donor hearts.Methods We analyzed 21 cases of orthotropic heart transplantation for end-stage heart disease performed in our department between September 2008 and July 2010. Of these patients, six received hearts from marginal donors and the remainder received standard-donor hearts. The two groups were compared in terms of both mortality and the incidence of perioperative complications such as infection, acute rejection, and right heart insufficiency.Results The 1-year survival rate of both groups was 100%. Only one death was recorded in standard-donor group during follow-up. Patients who received marginal donor hearts (83%) experienced more early complications than did the standard-donor-heart group (13%), but the mortality of the two groups was the same. The duration of post-ICU stay was greater in the marginal donor group than in the standard-donor group, (35.5±17.4) days and (21.7±2.6) days, respectively (P <0.05).Conclusions The use of marginal donor hearts increases the number of patients who can receive and benefit from transplants. However, it may introduce an increased risk of early complications, thus care should be taken both in the choice of patients who will receive marginal donor hearts and in the perioperative treatment of those for whom the procedure is performed.

  14. Evaluation of overall setup accuracy and adequate setup margins in pelvic image-guided radiotherapy: Comparison of the male and female patients

    Energy Technology Data Exchange (ETDEWEB)

    Laaksomaa, Marko, E-mail: [Department of Oncology, Tampere University Hospital (TAUH), Tampere (Finland); Kapanen, Mika [Department of Oncology, Tampere University Hospital (TAUH), Tampere (Finland); Department of Medical Physics, Tampere University Hospital (TAUH), Tampere (Finland); Tulijoki, Tapio [Department of Oncology, Tampere University Hospital (TAUH), Tampere (Finland); Peltola, Seppo; Hyödynmaa, Simo [Department of Oncology, Tampere University Hospital (TAUH), Tampere (Finland); Department of Medical Physics, Tampere University Hospital (TAUH), Tampere (Finland); Kellokumpu-Lehtinen, Pirkko-Liisa [Department of Oncology, Tampere University Hospital (TAUH), Tampere (Finland)


    We evaluated adequate setup margins for the radiotherapy (RT) of pelvic tumors based on overall position errors of bony landmarks. We also estimated the difference in setup accuracy between the male and female patients. Finally, we compared the patient rotation for 2 immobilization devices. The study cohort included consecutive 64 male and 64 female patients. Altogether, 1794 orthogonal setup images were analyzed. Observer-related deviation in image matching and the effect of patient rotation were explicitly determined. Overall systematic and random errors were calculated in 3 orthogonal directions. Anisotropic setup margins were evaluated based on residual errors after weekly image guidance. The van Herk formula was used to calculate the margins. Overall, 100 patients were immobilized with a house-made device. The patient rotation was compared against 28 patients immobilized with CIVCO's Kneefix and Feetfix. We found that the usually applied isotropic setup margin of 8 mm covered all the uncertainties related to patient setup for most RT treatments of the pelvis. However, margins of even 10.3 mm were needed for the female patients with very large pelvic target volumes centered either in the symphysis or in the sacrum containing both of these structures. This was because the effect of rotation (p ≤ 0.02) and the observer variation in image matching (p ≤ 0.04) were significantly larger for the female patients than for the male patients. Even with daily image guidance, the required margins remained larger for the women. Patient rotations were largest about the lateral axes. The difference between the required margins was only 1 mm for the 2 immobilization devices. The largest component of overall systematic position error came from patient rotation. This emphasizes the need for rotation correction. Overall, larger position errors and setup margins were observed for the female patients with pelvic cancer than for the male patients.

  15. Comparative riftology: insights from crustal structure into the evolution of continental rifts and passive continental margins (United States)

    Kley, Jonas; Stein, Carol; Stein, Seth; Keller, Randy; Wysession, Michael; Frederiksen, Andrew


    Continental rifts evolve to seafloor spreading and are preserved in passive margins, or fail and remain as fossil features in continents. Rifts at different stages give insight into these different evolutionary paths. Of particular interest is how volcanic passive margins evolve. These features are characterized by sequences of volcanic rocks yielding magnetic anomalies landward of and sometimes larger than the oldest spreading anomalies. Seaward-dipping reflectors (SDR) occur in stretched continental crust landward of the oldest oceanic crust and are underplated by high-velocity lower crustal bodies. How and when these features form remains unclear. Insights are given by the Midcontinent Rift (MCR), formed by 1.1 Ga rifting of Amazonia from Laurentia, that failed once seafloor spreading was established elsewhere. MCR volcanics are much thicker than other continental flood basalts, due to deposition in a narrow rift rather than a broad region, giving a rift's geometry but a LIP's magma volume. The MCR provides a snapshot of the deposition of a thick highly magnetized volcanic section during rifting. Surface exposures and seismic-reflection data in and near Lake Superior show a rift basin filled by inward-dipping flood basalt layers. Had the rift evolved to seafloor spreading, the basin would have split into two sets of volcanics with opposite-facing SDRs, each with a strong magnetic anomaly. Because the rift formed as a series of alternating half-grabens, structural asymmetries between conjugate margins can naturally occur. Hence the MCR shows that many features form prior to breakup. Because the MCR was massively inverted by regional compression long after it failed and was uplifted, its structure is better known than failed rifts that incurred lesser degrees of inversion. It provides an end member for the evolution of actively extending rifts, characterized by upwelling mantle and negative gravity anomalies, in contrast to failed and inverted rifts without

  16. Patents and profits: A disparity of manufacturing margins in the tenofovir value chain. (United States)

    Walwyn, David


    Registered in 2001, tenofovir disoproxil fumarate (TDF) has quickly become a mainstay of first line regimens for the treatment of HIV. Initially only available in developed countries at a cost of US$5 000 per person per year (ppy), Gilead's Access Programme (GAP) has extended the use of the product to 2.4 million patients in low and middle income countries. The programme has two components: distribution of the branded product at reduced prices and licensing partnerships with generic manufacturers. The licensing partnerships now supply 75% of the market by volume, at a treatment cost of US$57 ppy (1% of the branded cost). From Gilead's perspective, GAP must be considered a huge success. It has enabled the company to maintain high prices in developed countries whilst reducing its input costs and deflecting criticism of its failure to provide essential medicines for the poor, hence risking the possibility of compulsory licensing. Over the period 2001 to 2011, TDF in its various forms has generated for Gilead more than US$31 billion revenue at a gross margin of 80%, equivalent to a gross profit of US$25 billion. Analysis of the TDF value chain, from preparation of the active pharmaceutical ingredient (API) to sale of the formulated product, shows that manufacturing margins are highly skewed in favour of the originator, with the latter's profit being US$3.2 billion vs. US$4 million for API manufacturers and US$39 million for formulators (2011). The data argues for a more rational approach to drug pricing including possible regulation in developed countries and more sustainable margins for the generic producers.

  17. Crust-mantle accommodation of Africa-Eurasia convergence in the NW-Moroccan margin (United States)

    Zlotnik, S.; Jimenez-Munt, I.; Fernandez, M.


    Recent studies carried out in NW-Africa indicate prominent variations of the lithosphere-asthenosphere boundary (LAB) depth. The studies combine gravity, geoid, surface heat flow, elevation and seismic data along a profile running from the Tagus Abyssal Plain to the Sahara Platform and crossing the Gorringe Bank, the NW Moroccan Margin and the Atlas Mountains. The resulting mantle density anomalies show a prominent lithospheric mantle thickening beneath the margin (LAB >200 km-depth) followed by thinning beneath the Atlas Mountains (LAB ~90 km-depth). A combination of mantle underthrusting due to oblique convergence together with a viscous dripping fed by lateral mantle dragging can explain the imaged lithospheric structure. The model is consistent with a strong decoupled crustal-mantle mechanical response to the Africa-Eurasia convergence and results in positive/negative dynamic topography in regions with thickened/thinned crust. In this work we go a step further analysing, by means of dynamic numerical simulations, the viscous dragging and the Rayleigh-Taylor-like process. Our goal is to understand the initial lithospheric mantle structure suitable to produce the inferred dynamic process. In addition, we study the key factors controlling the deformation of the lithospheric mantle when submitted to convergence. Using the numerical framework Underworld to carry out the simulations we found the key factors controlling the process. Chief among these factors are lithospheric/mantle viscosity ratio and initial mantle and crustal structure. Nevertheless, the process is not very sensitive to the usual power law parameters for mantle rocks (activation energy and volume, power law exponent, etc.), indicating the importance of the rheology of the upper half of the lithosphere, where the power law is not active. These results allow us to speculate on the past and future evolution of the NW-Moroccan margin which could show the appropriated conditions for subduction initiation.

  18. Simulation of pulmonary movements for external radiotherapy; Simulation des mouvements pulmonaires pour la radiotherapie externe

    Energy Technology Data Exchange (ETDEWEB)

    Laurent, R.; Henriet, J.; Gschwind, R.; Makovicka, L. [IRMA/ENISYS/Institut FEMTO - UMR CNRS 6174, Pole Universitaire des Portes du Jura, 4 Place Tharradin - BP 71427, 25211 Montbeliard (France); Dumas, J.L.; Bosset, J.F. [Departement de Radiotherapie, CHU Jean Minjoz, 3 boulevard Flemming, 25030 Besancon (France)


    The Planning Target Volume (PTV) is one of the existing margins during the treatment of cancerous tumours by radiotherapy. It includes tumoral tissues as well as the patient positioning error between each radiotherapy session, and more particularly the intentional or unintentional patient movements. While focusing on pulmonary movements, and as the pulmonary tumour moves as the patient breathes, the authors aim at developing a weakly ionizing technique to catch the pulmonary movement of each patient, and therefore decrease the PTV. Several algorithms are implemented to process 2D and 3D images

  19. MRI Evaluation of Resection Margins in Bone Tumour Surgery

    Directory of Open Access Journals (Sweden)

    Simon Vandergugten


    Full Text Available In 12 patients operated on for bone sarcoma resection, a postoperative magnetic resonance imaging of the resection specimens was obtained in order to assess the surgical margins. Margins were classified according to MRI in R0, R1, and R2 by three independent observers: a radiologist and two orthopaedic surgeons. Final margin evaluation (R0, R1, and R2 was assessed by a confirmed pathologist. Agreement for margin evaluation between the pathologist and the radiologist was perfect (κ=1. Agreement between the pathologist and an experienced orthopaedic surgeon was very good while it was fair between the pathologist and a junior orthopaedic surgeon. MRI should be considered as a tool to give quick information about the adequacy of margins and to help the pathologist to focus on doubtful areas and to spare time in specimen analysis. But it may not replace the pathological evaluation that gives additional information about tumor necrosis. This study shows that MRI extemporaneous analysis of a resection specimen may be efficient in bone tumor oncologic surgery, if made by an experienced radiologist with perfect agreement with the pathologist.

  20. Clinical Outcomes of Endoscopic Hemostasis in Marginal Ulcer Bleeding. (United States)

    Yamasaki, Yasushi; Takenaka, Ryuta; Hori, Keisuke; Takemoto, Koji; Kawano, Seiji; Kawahara, Yoshiro; Fujiki, Shigeatsu; Okada, Hiroyuki


    The usefulness of endoscopy in marginal ulcer bleeding has rarely been studied, and the optimal method for preventing rebleeding is unclear. Here we assessed the efficacy of endoscopy in marginal ulcer bleeding and examined the efficacy of proton pump inhibitors (PPIs) in the prevention of rebleeding. A total of 28 patients with marginal ulcer bleeding (21 men, 7 women; median age 58.5 years) were treated by endoscopy. We analyzed the clinical characteristics, results of endoscopic therapy, characteristics of rebleeding patients, and relation between the use of PPIs and the duration of rebleeding. Sixteen patients had active bleeding. Initial hemostasis was achieved in all patients. There were no procedure-related adverse events. Rebleeding occurred in one patient within the first month and in 7 patients thereafter. There was a significant difference in the rebleeding rate between the patients who received a PPI and those who did not. In a multivariate analysis, the non-use of PPIs was a risk factor for rebleeding (hazard ratio, 6.22). Therapeutic endoscopy is effective in achieving hemostasis from marginal ulcer bleeding. PPIs may prevent rebleeding from marginal ulcers.

  1. Carbonate mound development in contrasting settings on the Irish margin (United States)

    van der Land, Cees; Eisele, Markus; Mienis, Furu; de Haas, Henk; Hebbeln, Dierk; Reijmer, John J. G.; van Weering, Tjeerd C. E.


    Cold-water coral carbonate mounds, formed by framework building cold-water corals, are found in several mound provinces on the Irish margin. Differences in cold-water coral mound development rates and sediment composition between mounds at the southwest Rockall Trough margin and the Galway Mound in the Porcupine Seabight are investigated. Variations in sediment composition in the two mound provinces are related to the local environmental conditions and sediment sources. Mound accumulation rates are possibly higher at the Galway Mound probably due to a higher influx of hemipelagic fine grained non-carbonate sediments. In both cold-water coral mound areas, mound growth has been continuous for the last ca 11,000 years, before this period several hiatuses and unconformities exist in the mound record. The most recent unconformity can be correlated across multiple mounds and mound provinces at the Irish margin on the basis of apparent age. On the southwest Rockall Trough margin these hiatuses/unconformities are associated with post-depositional aragonite dissolution in, and lithification of, certain intervals, while at Galway Mound no lithification occurs. This study revealed that the influx and types of material transported to cold-water coral mounds may have a direct impact on the carbonate mound accumulation rate and on post-depositional processes. Significantly, the Logachev Mounds on the SW Rockall Trough margin accumulate slower but, because they contain lithified layers, are less susceptible to erosion. This net effect may account for their larger size compared to the Belgica Mounds.

  2. Marginal land-based biomass energy production in China. (United States)

    Tang, Ya; Xie, Jia-Sui; Geng, Shu


    Fast economic development in China has resulted in a significant increase in energy demand. Coal accounts for 70% of China's primary energy consumption and its combustion has caused many environmental and health problems. Energy security and environmental protection requirements are the main drivers for renewable energy development in China. Small farmland and food security make bioenergy derived from corn or sugarcane unacceptable to China: the focus should be on generating bioenergy from ligno-cellulosic feedstock sources. As China cannot afford biomass energy production from its croplands, marginal lands may play an important role in biomass energy production. Although on a small scale, marginal land has already been used for various purposes. It is estimated that some 45 million hm(2) of marginal land could be brought into high potential biomass energy production. For the success of such an initiative, it will likely be necessary to develop multipurpose plants. A case study, carried out on marginal land in Ningnan County, Sichuan Province with per capita cropland of 0.07 ha, indicated that some 380,000 tons of dry biomass could be produced each year from annual pruning of mulberry trees. This study supports the feasibility of producing large quantities of biomass from marginal land sources.

  3. Influence of cavity depth on marginal degradation of amalgam restorations. (United States)

    Jokstad, A


    In a 5-year clinical trial it was observed that the marginal degradation of class-II amalgam restorations could be related to the bulk of the restoration. The association between the occlusal cavity depth and the marginal degradation was observed after 6 months and varied for the different types of alloy. Ridit scores of the marginal degradation were correlated to various indices of the cavity sizes, to assess the possible reason for this association. The possibilities of the relationship being an indirect effect caused by longer condensation times or by poorer condensation due to the use of larger condenser sizes were rejected. Furthermore, the possibility that the association was the result of potential buildup of stresses on the restoration margins caused by flexible cusps and axial walls was not apparent. A possible mechanism may be that marginal degradation is the result of short-term or long-term expansion, or even extrusion of amalgam. Expansion may theoretically be caused over short periods by temperature changes or over long periods by corrosion or phase shifts in the amalgam. The theory does not exclude the role of creep or corrosion and may furthermore explain the lack of correlation between in-vitro tests and in-vivo performance of amalgam restorations.

  4. On the Furthest Hyperplane Problem and Maximal Margin Clustering

    CERN Document Server

    Liberty, Edo; Weinstein, Omri


    This paper introduces the Furthest Hyperplane Problem (FHP). Given a set of $n$ points in $\\R^d$, the objective is to produce the hyperplane (through the origin) which maximizes the separation margin, that is, the minimal distance between the hyperplane and an input point. We prove that FHP is NP-hard to approximate to within some small (multiplicative) constant, by presenting a gap preserving reduction from a particular version of the PCP theorem. We also present an algorithm which runs in time $O(n^{\\tilde{O}(1/\\theta^2)})$ where $\\theta$ is the optimal margin. It is based on a dimension reduction technique combined with an $\\eps$-net argument in the reduced dimension. As a consequence, we obtain the first polynomial time algorithm for Maximal Margin Clustering (MMC), which is the unsupervised counterpart of Support Vector Machines (SVM), for the case where the margin is a constant factor of the point cloud diameter. Indeed, this is our main motivation. Our algorithm's running time dependance on the margin ...

  5. Assessment of bioenergy potential on marginal land in China

    Energy Technology Data Exchange (ETDEWEB)

    Zhuang, Dafang; Jiang, Dong; Liu, Lei; Huang, Yaohuan [Data Center for Resources and Environmental Sciences, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, 11A Datun Road, Chaoyang District, Beijing 100101 (China)


    Bioenergy developed from energy plants will play a more and more important role in future energy supply. Much attention has been paid to energy plants in recent years. As China has fairly limited cultivated land resources, the bioenergy development may mainly rely on the exploitation of marginal land. This study focused on the assessment of marginal land resources and bio-fuel potential in China using newly acquired data and Geographic Information System (GIS) techniques. A multi-factor analysis method was adopted to identify marginal lands for bioenergy development in China, with data of several main types of energy plants on the eco-environmental requirements and natural habits employed. A combined planting zonation strategy was proposed, which was targeted for five species of energy plants including Helianthus tuberous L., Pistacia chinensis, Jatropha curcas L., Cassava and Vernicia fordii. The results indicated that total area of marginal land exploitable for development of energy plants on a large scale was about 43.75 million ha. If 10% of this marginal land was fully utilized for growing the energy plants, the production of bio-fuel would be 13.39 million tons. (author)

  6. Tectonostratigraphic evolution of Cenozoic marginal basin and continental margin successions in the Bone Mountains, Southwest Sulawesi, Indonesia (United States)

    van Leeuwen, Theo M.; Susanto, Eko S.; Maryanto, Sigit; Hadiwisastra, Sapri; Sudijono; Muhardjo; Prihardjo


    The Bone Mountains, located in Southwest Sulawesi along the SE margin of Sundaland, are composed of Oligocene to possibly lower Miocene marginal basin successions (Bone Group) that are juxtaposed against continental margin assemblages of Eocene-Miocene age (Salokalupang Group). Three distinct units make up the latter: (i) Middle-Upper Eocene volcaniclastic sediments with volcanic and limestone intercalations in the upper part (Matajang Formation), reflecting a period of arc volcanism and carbonate development along the Sundaland margin; (ii) a well-bedded series of Oligocene calc-arenites (Karopa Formation), deposited in a passive margin environment following cessation of volcanic activity, and (iii) a series of Lower-Middle Miocene sedimentary rocks, in part turbiditic, which interfinger in the upper part with volcaniclastic and volcanic rocks of potassic affinity (Baco Formation), formed in an extensional regime without subduction. The Bone Group consists of MORB-like volcanics, showing weak to moderate subduction signatures (Kalamiseng Formation), and a series of interbedded hemipelagic mudstones and volcanics (Deko Formation). The Deko volcanics are in part subduction-related and in part formed from melting of a basaltic precursor in the overriding crust. We postulate that the Bone Group rocks formed in a transtensional marginal basin bordered by a transform passive margin to the west (Sundaland) and by a newly initiated westerly-dipping subduction zone on its eastern side. Around 14-13 Ma an extensional tectonic event began in SW Sulawesi, characterized by widespread block-faulting and the onset of potassic volcanism. It reached its peak about 1 Ma year later with the juxtaposition of the Bone Group against the Salokalupang Group along a major strike-slip fault (Walanae Fault Zone). The latter group was sliced up in variously-sized fragments, tilted and locally folded. Potassic volcanism continued up to the end of the Pliocene, and locally into the Quaternary.

  7. Getting to the bottom line. Hospitals' survival may hinge on the contribution margin. (United States)

    Margrif, F D


    Healthcare managers have devoted increasing attention to product line management in the face of growing competition. The general belief has been that although product line management and the contribution approach (internal financial reporting and analysis that distinguish between variable and fixed expenses and include the contribution margin) help enhance profitability for hospitals that have the prerequisite software systems and management expertise, they are hardly necessary for survival. But the contribution approach to product line management may indeed be required for survival for all hospitals. Current hospital accounting systems do not provide information on which products contribute to fixed expenses and profitability and which, although vital, are financial losers. Product line managers need this information to make optimal decision trade-offs among quality, availability, and benefits of medical services. The contribution margin is the difference between the fee received for the service and the variable expenses incurred in providing the service. It represents the resources available to cover fixed expenses that will occur regardless of volume and to provide a profit (or, for the not-for-profit, to provide working capital and expand services).

  8. Black locust (Robinia pseudoacacia L. Short-Rotation Crops under Marginal Site Conditions

    Directory of Open Access Journals (Sweden)

    RÉDEI, Károly


    Full Text Available The improvement of the reliability of renewable resources and the decline in reserves offossile raw material in the coming decades will lead to increasing demands for wood material andconsequently to a greater role of short rotation forestry (SRF. Particular efforts have been made inEurope to substitute fossils with renewables, in this context the proportion of renewable energy shouldbe increased to 20% by 2020. SRF can be provide relatively high dendromass (biomass incrementrates if the short rotation tree plantations are grown under favourable site conditions and for anoptimum rotation length. However, in many countries only so-called marginal sites are available forsetting up tree plantations for energy purpose. For SRF under marginal site conditions black locust(Robinia pseudoacacia L. can be considered as one of the most promising tree species thanks to itsfavourable growing characteristics. According to a case study presented in the paper black locust canproduce a Mean Annual Increment (MAI of 2.9 to 9.7 oven-dry tons ha–1 yr–1 at ages between 3 and7 years using a stocking density of 6667 stems ha–1. On the base of the presented results and accordingto international literature the expected dendromass volume shows great variation, depending upon site,species, their cultivars, initial spacing and length of rotation cycle.

  9. Major types of deep-water reservoirs from the Eastern Brazilian rift and passive margin basis

    Energy Technology Data Exchange (ETDEWEB)

    Bruhn, Carlos H.L. [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil). Exploracao e Producao


    Turbidites and associated deep-water facies comprise the most important petroleum reservoirs in Brazil. They contain in place volumes of 57.2 billion bbl of oil, and 27.5 trillion cubic feet of gas, and total reserves of 12.5 billion bbl of oil, and 8.3 trillion cubic feet of gas. Brazilian petroleum-bearing turbidites occur in Carboniferous/Permian, glaciomarine pre-rift (interior cratonic) successions, Neocomian to Aptian, lacustrine rift successions and Upper Albian to Lower Miocene, marine passive margin successions. Most of the petroleum accumulations are distributed along the eastern Brazilian margin, which tectonic and sedimentary evolution is linked to the Neocomian breakup of Gondwana and the subsequent opening of the South Atlantic Ocean. Turbidites comprise 553 production zones from 171 oil and/or gas fields, mostly concentrated in the Campos, Reconcavo, Sergipe/Alagoas, and Espirito Santo basins. This paper presents an overview of the sedimentary facies, high-resolution stratigraphy, sand body geometry, and reservoir heterogeneities of the major types of Brazilian deep-water reservoirs, which include gravel/sand-rich, turbidite channel complexes, though-confined, gravel/sand-rich turbidite lobes, gravel/sand-rich turbidite and debrite aprons, deposits of sand-rich, lacustrine density underflows, deposits of sand/mud-rich debris flows, and deposits of sandy bottom currents. (author)

  10. Theory of margination and cell-free layer thickness in blood flow (United States)

    Graham, Michael


    A mechanistic model is developed to describe segregation in confined multicomponent suspensions such as blood during Couette or plane Poiseuille flow. We focus attention on the case of a binary suspension with a deformable primary component (e.g. red blood cells) that completely dominates the collision dynamics in the system. The model captures the phenomena of depletion layer formation and margination observed in confined multicomponent suspensions of deformable particles. The depletion layer thickness of the primary component is predicted to follow a master curve relating it in a specific way to confinement ratio and volume fraction. Results from experiments and detailed simulations with different parameters (flexibility, viscosity ratio, confinement) collapse onto this curve with only one adjustable parameter. In a binary suspension, several regimes of segregation arise, depending on the value of a "margination parameter" M. Most importantly, in both Couette and Poiseuille flows there is a critical value of M below which a sharp "drainage transition" occurs: one component is completely depleted from the bulk flow to the vicinity of the walls. Direct simulations also exhibit this transition as the size or flexibility ratio of the components changes.

  11. Ice stratigraphy at the Pakitsoq ice margin, West Greenland, derived from gas records

    DEFF Research Database (Denmark)

    Schaefer, H.; Petrenko, V. V.; Brook, E. J.;


    Horizontal ice-core sites, where ancient ice is exposed at the glacier surface, offer unique opportunities for paleo-studies of trace components requiring large sample volumes. Following previous work at the Pakitsoq ice margin in West Greenland, we use a combination of geochemical parameters...... measured in the ice matrix (delta O-18(ice)) and air occlusions (delta O-18(atm), delta N-15 of N-2 and methane concentration) to date ice layers from specific climatic intervals. The data presented here expand our understanding of the stratigraphy and three-dimensional structure of ice layers outcropping...... at Pakitsoq. Sections containing ice from every distinct climatic interval during Termination I, including Last Glacial Maximum, Bolling/Allerod, Younger Dryas and the early Holocene, are identified. In the early Holocene, we find evidence for climatic fluctuations similar to signals found in deep ice cores...

  12. Comparison of Safety Margin Generation Concepts in Image Guided Radiotherapy to Account for Daily Head and Neck Pose Variations (United States)

    Stoiber, Eva Maria; Grimm, Sarah; Debus, Jürgen; Bendl, Rolf; Giske, Kristina


    Purpose Intensity modulated radiation therapy (IMRT) of head and neck tumors allows a precise conformation of the high-dose region to clinical target volumes (CTVs) while respecting dose limits to organs a risk (OARs). Accurate patient setup reduces translational and rotational deviations between therapy planning and therapy delivery days. However, uncertainties in the shape of the CTV and OARs due to e.g. small pose variations in the highly deformable anatomy of the head and neck region can still compromise the dose conformation. Routinely applied safety margins around the CTV cause higher dose deposition in adjacent healthy tissue and should be kept as small as possible. Materials and Methods In this work we evaluate and compare three approaches for margin generation 1) a clinically used approach with a constant isotropic 3 mm margin, 2) a previously proposed approach adopting a spatial model of the patient and 3) a newly developed approach adopting a biomechanical model of the patient. All approaches are retrospectively evaluated using a large patient cohort of over 500 fraction control CT images with heterogeneous pose changes. Automatic methods for finding landmark positions in the control CT images are combined with a patient specific biomechanical finite element model to evaluate the CTV deformation. Results The applied methods for deformation modeling show that the pose changes cause deformations in the target region with a mean motion magnitude of 1.80 mm. We found that the CTV size can be reduced by both variable margin approaches by 15.6% and 13.3% respectively, while maintaining the CTV coverage. With approach 3 an increase of target coverage was obtained. Conclusion Variable margins increase target coverage, reduce risk to OARs and improve healthy tissue sparing at the same time. PMID:28033416

  13. Plasma concentration of 3-hydroxyisovaleryl carnitine is an early and sensitive indicator of marginal biotin deficiency in humans1234 (United States)

    Stratton, Shawna L; Horvath, Thomas D; Bogusiewicz, Anna; Matthews, Nell I; Henrich, Cindy L; Spencer, Horace J; Moran, Jeffery H; Mock, Donald M


    Background: Blood-based indicators of biotin status in humans were shown to be useful tools in several clinical situations, including pregnancy. We previously validated the activity of the biotin-dependent enzyme propionyl-coenzyme A carboxylase (PCC) in lymphocytes as a sensitive and specific blood-based indicator of marginal degrees of biotin deficiency. However, the measurement of PCC activity in population studies presents substantial analytic challenges. 3-Hydroxyisovaleryl carnitine (3HIA-carnitine) increases in response to the decreased activity of the biotin-dependent enzyme methylcrotonyl-coenzyme A carboxylase and might reflect biotin status. Objective: We sought to determine whether the plasma concentration of 3HIA-carnitine increases significantly in marginal biotin deficiency. Design: We experimentally induced marginal, asymptomatic biotin deficiency in 10 healthy adults (8 women) by having the subjects consume undenatured egg white for 28 d; biotin status was then repleted. Plasma concentrations of 3HIA-carnitine were measured on days 0, 14, 28, 35, and 50 by liquid chromatography–mass spectroscopy. Results: The mean plasma 3HIA-carnitine concentration increased with depletion (P < 0.0001) and decreased with repletion (P < 0.0001). Plasma 3HIA-carnitine concentrations were greater than the upper limit of normal concentrations in 7 of 10 subjects by day 14 and in 9 of 10 subjects by day 28 and decreased to within normal limits in 9 of 10 subjects by day 50. Conclusions: These studies provide evidence that 3HIA-carnitine is an early and sensitive indicator of marginal biotin deficiency. The ease of sample collection, small sample volume requirement, and stability of 3HIA-carnitine during storage suggest that plasma 3HIA-carnitine concentration is likely to be a useful indicator of marginal biotin deficiency for larger population studies. PMID:20943794

  14. A comparative analysis of primary and secondary Gleason pattern predictive ability for positive surgical margins after radical prostatectomy. (United States)

    Sfoungaristos, S; Kavouras, A; Kanatas, P; Polimeros, N; Perimenis, P


    To compare the predictive ability of primary and secondary Gleason pattern for positive surgical margins in patients with clinically localized prostate cancer and a preoperative Gleason score ≤ 6. A retrospective analysis of the medical records of patients undergone a radical prostatectomy between January 2005 and October 2010 was conducted. Patients' age, prostate volume, preoperative PSA, biopsy Gleason score, the 1st and 2nd Gleason pattern were entered a univariate and multivariate analysis. The 1st and 2nd pattern were tested for their ability to predict positive surgical margins using receiver operating characteristic curves. Positive surgical margins were noticed in 56 cases (38.1%) out of 147 studied patients. The 2nd pattern was significantly greater in those with positive surgical margins while the 1st pattern was not significantly different between the 2 groups of patients. ROC analysis revealed that area under the curve was 0.53 (p=0.538) for the 1st pattern and 0.60 (p=0.048) for the 2nd pattern. Concerning the cases with PSA <10 ng/ml, it was also found that only the 2nd pattern had a predictive ability (p=0.050). When multiple logistic regression analysis was conducted it was found that the 2nd pattern was the only independent predictor. The second Gleason pattern was found to be of higher value than the 1st one for the prediction of positive surgical margins in patients with preoperative Gleason score ≤ 6 and this should be considered especially when a neurovascular bundle sparing radical prostatectomy is planned, in order not to harm the oncological outcome.

  15. Volume Regulated Channels

    DEFF Research Database (Denmark)

    Klausen, Thomas Kjær

    - serves a multitude of functions in the mammalian cell, regulating the membrane potential (Em), cell volume, protein activity and the driving force for facilitated transporters giving Cl- and Cl- channels a major potential of regulating cellular function. These functions include control of the cell cycle...... of volume perturbations evolution have developed system of channels and transporters to tightly control volume homeostasis. In the past decades evidence has been mounting, that the importance of these volume regulated channels and transporters are not restricted to the defense of cellular volume......, controlled cell death and cellular migration. Volume regulatory mechanisms has long been in focus for regulating cellular proliferation and my thesis work have been focusing on the role of Cl- channels in proliferation with specific emphasis on ICl, swell. Pharmacological blockage of the ubiquitously...

  16. Improved statistical confirmation of margins for setpoints and transients

    Energy Technology Data Exchange (ETDEWEB)

    Nutt, W.T. [Framatome ANP Richland, INC., WA (United States)


    Framatome ANP Richland, Inc. has developed an integrated, automated, statistical methodology for Pressurized Water Reactors (PWRs). Margins for transients and calculated trips are confirmed using several new applications of probability theory. The methods used for combining statistics reduces the conservatisms inherent in conventional methods and avoids the numerical limitations and time constraints imposed by Monte Carlo techniques. The new methodology represents the state of the art in the treatment of uncertainties for reactor protection systems. It all but eliminates concerns with the calculated trips for PWRs and by improving the margin for all transients will allow for far more aggressive peaking limits and fuel management schemes. The automated nature of the bulk of this process saves Framatome ANP time and effort, minimizes the potential for errors and makes the analysis for all cycles and plants consistent. The enhanced margins remove analytical limitations from the customer and allow for more economical operation of the plant. (authors)

  17. An assessment of seismic margins in nuclear plant piping

    Energy Technology Data Exchange (ETDEWEB)

    Chen, W.P.; Jaquay, K.R. [Energy Technology Engineering Center, Canoga Park, CA (United States); Chokshi, N.C.; Terao, D. [Nuclear Regulatory Commission, Washington DC (United States)


    Interim results of an ongoing program to assist the U.S. Nuclear Regulatory Commission (NRC) in developing regulatory positions on the seismic analyses of piping and overall safety margins of piping systems are reported. Results of: (1) reviews of seismic testing of piping components performed as part of the Electric Power Research Institute (EPRI)/NRC Piping and Fitting Dynamic Reliability (PFDR) Program, and (2) assessments of safety margins inherent in the ASME Code, Section III, piping seismic design criteria as revised by the 1994 Addenda are reported. The reviews indicate that the margins inherent in the revised criteria may be less than acceptable and that modifications to these criteria may be required.

  18. Post Rift Evolution of the Indian Margin of Southern Africa (United States)

    Baby, Guillaume; Guillocheau, François; Robin, Cécile; Dall'asta, Massimo


    The objective of this study is to discuss the evolution of the South African Plateau along the Indian margin of Southern Africa. Since the classical works of A. du Toit and L.C. King and the improvement of thermochronological methods and numerical models, the question of the uplift of South African Plateau was highly debated with numerous scenarios: early Cretaceous at time of rifting (Van der Beek et al., J.Geophys.Res., 2002), late Cretaceous (Braun et al., Solid Earth, 2014), late Cenozoic (Burke & Gunnell, Geol.Soc.of America, 2008). Limited attention has been paid on the constraints provided by the offshore stratigraphic record of the surrounding margins. The objective of our study is to integrate onshore and offshore data (seismic profiles and industrial wells) to (1) analyse the infill of the whole margin (21°S to 31°S) from its hinterland to the distal deep water basin, (2) to constrain and quantify the vertical movements. We discuss the impact on accommodation and sediments partitioning, and their significance on South African Plateau uplift history. 1. Sedimentary basins of the Indian margin of Southern Africa are related to the break-up of Gondwana during late Jurassic, resulting in rifts and flexural basins. First marine incursions started during early Cretaceous times (oldest marine outcropping sediments are of Barremian age ~128 Ma). The region developed as a normal continental shelf at the Aptian-Albian transition (~113 Ma). 2. The Cretaceous geological history of the basins is characterized by differential uplift and subsidence of the basement, controlled by structures inherited from break up. As example, major early Cretaceous depocenters of the margin are located on the north of Save-Limpopo uplift (Forster, Paleogography, Paleoclimatology, Paleoecology, 1975) showing an eastward drainage pattern, maybe related to a proto Limpopo drainage. Those observations suggest that the escarpment bordering the Bushveld depression is an old relief inherited

  19. Reconstructing marginality: a new model of cultural diversity in nursing. (United States)

    Southwick, Margaret; Polaschek, Nick


    This article presents a new model of cultural diversity in nursing that critically reconstructs the concept of marginality that underpins other models. Rather than viewing the marginal as "other," marginality is redefined as the space in between the dominant cultural reality and the cultural realities of minority groups located within a society. Members of a minority cultural group who become skilled in the difficult process of negotiating this in-between space open the possibility of transformation within nursing education and practice. This model has been applied in a study of the experience of nursing students of Pacific ethnicity in New Zealand. Subsequently, an undergraduate Pacific nursing program was developed, with greatly increased success rates in registration of Pacific nurses. This model of cultural diversity can also be used to understand nursing practice involving people from minority cultures or other socially excluded categories.

  20. Critical behavior of marginal aperiodic sequences: a Monte Carlo study (United States)

    Branco, Nilton


    We study layered marginal aperiodic sequences for the Ising and q=8 Potts model on a square lattice. The phase transition is continuous for the former and first-order for the latter. Using the Wolff algorithm we calculate critical exponents and the critical temperature for the Potts model when the interaction constant can assume two values, according to an aperiodic sequence: the period-doubling one for the Ising model and the Fibonacci one for the Potts model. These sequences and models chracterize marginal critical behavior, according to the Luck criterion and, therefore, interaction-dependent exponents are expected for a continuous transition. For first-order phase transitions, no study so far has been done on the influence of marginal sequences.

  1. Natural Gas Venting on the Northern Cascadia Margin (United States)

    Scherwath, M.; Riedel, M.; Roemer, M.; Paull, C. K.; Spence, G.; Veloso, M.


    Over the past decades, hundreds of natural gas vents have been observed along the Northern Cascadia Margin in the Northeast Pacific, and we present a summary of these observations from offshore Vancouver Island, BC, Canada. We have gathered observed locations and analyzed original data from published literature as well as research cruises and fishing sonar from various archives. By far the highest accumulation of gas vent locations appear both shallow (100-200 m) and concentrated towards the mouth of the Juan de Fuca Strait, however these observations are naturally biased toward the distribution of the observation footprints. Normalized observations confirm the shallow high concentrations of gas vents but also establish some deeper sections of focused venting activity. We will speculate about the reasons behind the distribution, focus on specific examples, extrapolate for rough margin flux rate ranges and comment on short-comings and future directions for margin-wide gas vent studies.

  2. On the marginally relevant operator in z=2 Lifshitz holography

    Energy Technology Data Exchange (ETDEWEB)

    Holsheimer, Kristian [Institute of Physics, University of Amsterdam,Science Park 904, Postbus 94485, 1090 GL Amsterdam (Netherlands)


    We study holographic renormalization and RG flow in a strongly-coupled Lifshitz-type theory in 2+1 dimensions with dynamical exponent z=2. The bottom-up gravity dual we use is 3+1 dimensional Einstein gravity coupled to a massive vector field. This model contains a marginally relevant operator around the Lifshitz fixed point. We show how holographic renormalization works in the presence of this marginally relevant operator without the need to introduce explicitly cutoff-dependent counterterms. A simple closed-form expression is found for the renormalized on-shell action. We also discuss how asymptotically Lifshitz geometries flow to AdS in the interior due to the marginally relevant operator. We study the behavior of the renormalized entanglement entropy and confirm that it decreases monotonically along the Lifshitz-to-AdS RG flow.

  3. Potato production in Europe - a gross margin analysis

    DEFF Research Database (Denmark)

    Pedersen, Søren Marcus; Bizik, Jan; Costa, Luisa Dalla;

    The purpose of this paper is to examine different cropping practices, cost structures and gross margins for producing conventional table potatoes in 6 different regions within the European Union: Czech Republic, Denmark, Italy, Poland, Portugal and Slovakia. Findings from this study show that pot......The purpose of this paper is to examine different cropping practices, cost structures and gross margins for producing conventional table potatoes in 6 different regions within the European Union: Czech Republic, Denmark, Italy, Poland, Portugal and Slovakia. Findings from this study show...... that potato cropping practices varies signifi-cantly between these countries with major differences in yields and costs. Italy and Denmark are the two regions with highest gross margins due to high yields and reve-nues. Poland is by far the largest potato producing country among the 6 countries ex...

  4. Marginal production in the Gulf of Mexico - II. Model results

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, Mark J.; Yu, Yunke [Center for Energy Studies, Louisiana State University, Baton Rouge, LA 70803 (United States)


    In the second part of this two-part article on marginal production in the Gulf of Mexico, we estimate the number of committed assets in water depth less than 1000 ft that are expected to be marginal over a 60-year time horizon. We compute the expected quantity and value of the production and gross revenue streams of the gulf's committed asset inventory circa. January 2007 using a probabilistic model framework. Cumulative hydrocarbon production from the producing inventory is estimated to be 1056 MMbbl oil and 13.3 Tcf gas. Marginal production from the committed asset inventory is expected to contribute 4.1% of total oil production and 5.4% of gas production. A meta-evaluation procedure is adapted to present the results of sensitivity analysis. Model results are discussed along with a description of the model framework and limitations of the analysis. (author)

  5. The Cadiz margin study off Spain: An introduction (United States)

    Nelson, C.H.; Maldonado, A.


    The Cadiz continental margin of the northeastern Gulf of Cadiz off Spain was selected for a multidisciplinary project because of the interplay of complex tectonic history between the Iberian and African plates, sediment supply from multiple sources, and unique Mediterranean Gateway inflow and outflow currents. The nature of this complex margin, particularly during the last 5 million years, was investigated with emphasis on tectonic history, stratigraphic sequences, marine circulation, contourite depositional facies, geotechnical properties, geologic hazards, and human influences such as dispersal of river contaminants. This study provides an integrated view of the tectonic, sediment supply and oceanographic factors that control depositional processes and growth patterns of the Cadiz and similar modem and ancient continental margins.

  6. Isotropy and marginally trapped surfaces in a spacetime

    Energy Technology Data Exchange (ETDEWEB)

    Cabrerizo, J L; Fernandez, M; Gomez, J S, E-mail: jaraiz@us.e, E-mail: mafernan@us.e, E-mail: jsalvador@us.e [Geometria y Topologia, Universidad de Sevilla, Apdo. 1160, 41080 Sevilla (Spain)


    In this paper we shall study the notions of an isotropic and marginally trapped surface in a spacetime by using a differential geometric approach. We first consider spacelike isotropic surfaces in a Lorentzian manifold and, in particular, in a four-dimensional spacetime, where the isotropy function appears to be determined by the mean curvature vector field of the surface. Explicit examples of isotropic marginally outer trapped surfaces are given in the standard four-dimensional space forms: Minkowski, de Sitter and anti-de Sitter spaces. Then we prove rigidity theorems for complete spacelike 0-isotropic surfaces without flat points in these standard space forms. As a consequence, we also obtain characterizations of complete spacelike isotropic marginally trapped surfaces in these backgrounds.

  7. SU-F-BRF-07: Impact of Different Patient Setup Strategies in Adaptive Radiation Therapy with Simultaneous Integrated Volume-Adapted Boost of NSCLC

    Energy Technology Data Exchange (ETDEWEB)

    Balik, S [Cleveland Clinic Foundation, Cleveland, OH (United States); Weiss, E; Sleeman, W; Wu, Y; Hugo, G [Virginia Commonwealth University, Richmond, VA (United States); Dogan, N [University of Miami, Miami, FL (United States); Fatyga, M [Mayo Clinic, AZ, Phoenix, AZ (United States)


    Purpose: To evaluate the potential impact of several setup error correction strategies on a proposed image-guided adaptive radiotherapy strategy for locally advanced lung cancer. Methods: Daily 4D cone-beam CT and weekly 4D fan-beam CT images were acquired from 9 lung cancer patients undergoing concurrent chemoradiation therapy. Initial planning CT was deformably registered to daily CBCT images to generate synthetic treatment courses. An adaptive radiation therapy course was simulated using the weekly CT images with replanning twice and a hypofractionated, simultaneous integrated boost to a total dose of 66 Gy to the original PTV and either a 66 Gy (no boost) or 82 Gy (boost) dose to the boost PTV (ITV + 3mm) in 33 fractions with IMRT or VMAT. Lymph nodes (LN) were not boosted (prescribed to 66 Gy in both plans). Synthetic images were rigidly, bony (BN) or tumor and carina (TC), registered to the corresponding plan CT, dose was computed on these from adaptive replans (PLAN) and deformably accumulated back to the original planning CT. Cumulative D98% of CTV of PT (ITV for 82Gy) and LN, and normal tissue dose changes were analyzed. Results: Two patients were removed from the study due to large registration errors. For the remaining 7 patients, D98% for CTV-PT (ITV-PT for 82 Gy) and CTV-LN was within 1 Gy of PLAN for both 66 Gy and 82 Gy plans with both setup techniques. Overall, TC based setup provided better results, especially for LN coverage (p = 0.1 for 66Gy plan and p = 0.2 for 82 Gy plan, comparison of BN and TC), though not significant. Normal tissue dose constraints violated for some patients if constraint was barely achieved in PLAN. Conclusion: The hypofractionated adaptive strategy appears to be deliverable with soft tissue alignment for the evaluated margins and planning parameters. Research was supported by NIH P01CA116602.

  8. Closing the North American Carbon Budget: Continental Margin Fluxes Matter! (United States)

    Najjar, R.; Benway, H. M.; Siedlecki, S. A.; Boyer, E. W.; Cai, W. J.; Coble, P. G.; Cross, J. N.; Friedrichs, M. A.; Goni, M. A.; Griffith, P. C.; Herrmann, M.; Lohrenz, S. E.; Mathis, J. T.; McKinley, G. A.; Pilskaln, C. H.; Smith, R. A.; Alin, S. R.


    Despite their relatively small surface area, continental margins are regions of intense carbon and nutrient processing, export and exchange, and thus have a significant impact on global biogeochemical cycles. In response to recommendations for regional synthesis and carbon budget estimation for North America put forth in the North American Continental Margins workshop report (Hales et al., 2008), the Ocean Carbon and Biogeochemistry (OCB) Program and North American Carbon Program (NACP) began coordinating a series of collaborative, interdisciplinary Coastal CARbon Synthesis (CCARS) research activities in five coastal regions of North America (Atlantic Coast, Pacific Coast, Gulf of Mexico, Arctic, Laurentian Great Lakes) to improve quantitative assessments of the North American carbon budget. CCARS workshops and collaborative research activities have resulted in the development of regional coastal carbon budgets based on recent literature- and model-based estimates of major carbon fluxes with estimated uncertainties. Numerous peer-reviewed papers and presentations by involved researchers have highlighted these findings and provided more in-depth analyses of processes underlying key carbon fluxes in continental margin systems. As a culminating outcome of these synthesis efforts, a comprehensive science plan highlights key knowledge gaps identified during this synthesis and provides explicit guidance on future research and observing priorities in continental margin systems to help inform future agency investments in continental margins research. This presentation will provide an overview of regional and flux-based (terrestrial inputs, biological transformations, sedimentary processes, atmospheric exchanges, lateral carbon transport) synthesis findings and key recommendations in the science plan, as well as a set of overarching priorities and recommendations on observations and modeling approaches for continental margin systems.

  9. Precision volume measurement system.

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Erin E.; Shugard, Andrew D.


    A new precision volume measurement system based on a Kansas City Plant (KCP) design was built to support the volume measurement needs of the Gas Transfer Systems (GTS) department at Sandia National Labs (SNL) in California. An engineering study was undertaken to verify or refute KCP's claims of 0.5% accuracy. The study assesses the accuracy and precision of the system. The system uses the ideal gas law and precise pressure measurements (of low-pressure helium) in a temperature and computer controlled environment to ratio a known volume to an unknown volume.

  10. Marginal Congestion Cost on a Dynamic Expressway Network

    DEFF Research Database (Denmark)

    Fosgerau, Mogens; Small, Kenneth A.


    a dynamic econometric model using unusually complete and accurate data from Danish motorways. We use the results to estimate the marginal external cost of adding a vehicle to a link's entry flow, finding it is highly influenced by the dynamic properties of the system of relationships between travel times......We formulate an empirical model of congestion for a series of sequential expressway links where queues may form and spill back. Its purpose is to disentangle the dynamic effect that a marginal vehicle has on the distribution of travel times experienced there and on connected links. We estimate...

  11. Nadir Margins in TerraSAR-X Timing Commanding


    Wollstadt, Steffen; Mittermayer, Josef


    This paper presents an analysis and discussion of the Nadir return in the context of radar timing. Results obtained during the Commissioning Phase of TerraSAR-X in verification and measurement of Nadir return and timing margins are shown. Pre-launch assumptions about the Nadir margins were verified and optimized, which led to an improvement in the timing commanding, i.e. a relaxing of the timing. By means of three early acquired TerraSAR-X images which contain Nadir re...

  12. Passive margins getting squeezed in the mantle convection vice (United States)

    Husson, Laurent; Yamato, Philippe; Becker, Thorsten; Pedoja, Kevin


    Quaternary coastal geomorphology reveals that passive margins underwent wholesale uplift at least during the glacial cycle. In addition, these not-so-passive margins often exhibit long term exhumation and tectonic inversion, which suggest that compression and tectonic shortening could be the mechanism that triggers their overall uplift. We speculate that the compression in the lithosphere gradually increased during the Cenozoic. The many mountain belts at active margins that accompany this event readily witness this increase. Less clear is how that compression increase affects passive margins. In order to address this issue, we design minimalist 2D viscous models to quantify the impact of plate collision on the stress regime. In these models, a sluggish plate is disposed on a less viscous mantle. It is driven by a "mantle conveyor belt" alternatively excited by lateral shear stresses that represent a downwelling on one side, an upwelling on the other side, or both simultaneously. The lateral edges of the plate are either free or fixed, respectively representing the cases of free convergence and collision. In practice, it dramatically changes the upper boundary condition for mantle circulation and subsequently, for the stress field. The flow pattern transiently evolves almost between two end-members, starting from a situation close to a Couette flow to a pattern that looks like a Poiseuille flow with an almost null velocity at the surface (though in the models, the horizontal velocity at the surface is not strictly null, as the lithosphere deforms). In the second case, the lithosphere is highly stressed horizontally and deforms. For an equivalent bulk driving force, compression increases drastically at passive margins if upwellings are active because they push plates towards the collision. Conversely, if only downwellings are activated, compression occurs on one half of the plate and extension on the other half, because only the downwelling is pulling the plate

  13. Marginal pricing and supplement cost allocation in transmission open access

    Energy Technology Data Exchange (ETDEWEB)

    Rudnick, H.; Palma, R.; Fernandez, J.E. [Pontificia Univ. Catolica de Chile, Santiago (Chile). Escuela de Ingenieria


    The application of marginal costing to transmission pricing in open access schemes requires the collection of a supplement to finance the transmission systems. The paper describes the application of marginal cost based pricing in the Chilean power system and the difficulties faced in allocating the supplement among parties involved. Alternatives methods for defining the allocation are formulated. Generalized generation and load distribution factors for cost allocation are formulated and implemented. The methods are applied to allocate payments for transmission services provided by the transmission network and by a distribution company.

  14. Soft Drink Influence on Margin Integrity in Composite Resin Restorations


    Lafuente DDS, MS, Jose; Abad DDS, Karol


    The purpose of this study was to evaluate the effect that certain previously selected soda drinks could have on the integrity of the margins of composite restorations made on 25 human teeth, where the margins were placed both on enamel and dentin. Specimens were divided in different groups (n=5) to be exposed to soft drinks 30 minutes a day for 30 days. Selected drinks were: Coca Cola, Coca Cola Zero, Squirt, Gladiator and water. SEM pictures were taken at the beginning and at the 30 day mark...

  15. Tight Sample Complexity of Large-Margin Learning

    CERN Document Server

    Sabato, Sivan; Tishby, Naftali


    We obtain a tight distribution-specific characterization of the sample complexity of large-margin classification with L_2 regularization: We introduce the \\gamma-adapted-dimension, which is a simple function of the spectrum of a distribution's covariance matrix, and show distribution-specific upper and lower bounds on the sample complexity, both governed by the \\gamma-adapted-dimension of the source distribution. We conclude that this new quantity tightly characterizes the true sample complexity of large-margin classification. The bounds hold for a rich family of sub-Gaussian distributions.

  16. Asymptotic Marginal Tax Rate of Individual Income Tax in China

    Institute of Scientific and Technical Information of China (English)



    This paper examines the asymptotic marginal rate of individual income tax which maximizes China’s social welfare through numerical simulation based on the elasticity of China’s labor supply, income distribution and the social objectives of redistribution in accordance with the optimal direct taxation theory. Taking advantage of the optimal direct taxation model with consideration of the income effect, it comes to the conclusion that combined with China’s reality, the asymptotic marginal rate of individual labor income tax in China should be between 35% and 40%.

  17. How a Curvilinear Continental Margin Influences Its Subsidence History (United States)

    Sacek, V.; Ussami, N.


    Current one-dimensional (1D) and two-dimensional (2D) thermo-mechanical models successfully explain the first-order vertical motions of sedimentary basins created by lithospheric extension. However, the modeling of second-order effects such as extra-subsidence, non-monotonic-subsidence or protracted-subsidence still remains controversial. One aspect that has not been fully considered in the current models is that the rifting direction leading to the continental break-up does not always follow a straight line, which demands a three-dimensional (3D) approach. The aim of this work is to demonstrate the importance of using a 3D model that takes into account the curvature of rifting along the margin and theoretically predicts some of the second-order subsidence observations. Our results indicate that concave oceanward margins tend to subside faster than convex ones. This differential subsidence of the margin is a result of the combined effect of lateral thermal conduction, small-scale mantle (or edge driven) convection and the curvature of the rifting. We have used the finite element code CITCOM (Moresi & Gurnis, 1996; Zhong et al., 2000) to construct 3D numerical models of the mantle convection and its effect on the surface evolution. We observed that the differential subsidence along a curved margin is dependent on the viscosity structure of the mantle: for an asthenospheric viscosity of 5×1020 Pa.s the differential subsidence can reach more than 700 m assuming a sediment filled basin; however, for low asthenospheric viscosity (geometry. As an application of this 3D conceptual model for curved margin, we analysed the stratigraphic evolution of the Santos Basin, offshore Southeastern Brazil, and we propose that the variations in the subsidence history along the margin can be explained by its 3D geometry and the dynamical evolution of the mantle. We conclude that the incorporation of the third dimension in the study of the subsidence history of divergent margins may

  18. Marginal linearization method in modeling on fuzzy control systems

    Institute of Scientific and Technical Information of China (English)


    Marginal linearization method in modeling on fuzzy control systems is proposed, which is to deal with the nonlinear model with variable coefficients. The method can turn a nonlinear model with variable coefficients into a linear model with variable coefficients in the way that the membership functions of the fuzzy sets in fuzzy partitions of the universes are changed from triangle waves into rectangle waves. However, the linearization models are incomplete in their forms because of their lacking some items. For solving this problem, joint approximation by using linear models is introduced. The simulation results show that marginal linearization models are of higher approximation precision than their original nonlinear models.

  19. Marginal granilocytic pool in the treatment of malignant tumors

    Energy Technology Data Exchange (ETDEWEB)

    Angelova, I.; Bakalov, M.; Zografov, D. (Meditsinska Akademiya, Sofia (Bulgaria). Nauchen Inst. po Rentgenologiya i Radiobiologiya)


    Using the adrenaline test in 57 patients with malignant tumors, the authors examined the marginal granulocytic pool at different time in the course of treatment. The state of the pool was correlated with that of the neutrophilic cells in the circulating blood and with its state before treatment was started. It is concluded that in the course of treatment the neutrophilic cell counts in the marginal cells pool undergo changes similar to those in the circulation pool. It is therefore unjustifiable to include the adrenaline test in the control examination of patients with leucopenia.


    Directory of Open Access Journals (Sweden)

    Burba, Domininkas


    Full Text Available This article presents and discusses fourteen drawings that portray a human and were found in manuscripts and printed books (documents that were actively used in Lithuania from 17th to 19th centuries. All the drawings were made in the margins of the documents. For the authors the drawings were not planned work but more like quips, scribbles and doodles. Therefore the terms portrait graffiti and (as a synonym portrait marginalia are used to describe the discussed portraits. According to the formal classification of marginal drawings (suggested by J. Liskeviciene two of the examined marginal portraits (no. 10 and 14 are classed as seperate and finished works with their own composition; ten marginal portraits (no. 2, 4, 5, 6, 7, 8, 9, 11, 12 and 13 represent the readers (document users sketch like drawings. Two other portraits (no. 1 and 3 are just scribbles that have nothing to do with artictic perception and are very close to book graffiti. From the artistic approcah the most sophisticated of the marginal portraits are “the hunt scene” (no. 14 and the late (first half of the 19th century “portrait of the teacher” (no. 13. In the viewpoint of documentary and social communication the discussed marginal drawings did not have a direct addressee. They were made not for public but for personal use. Paleographical, structural and content analysis of the document showed that the author of the “bearded nobleman” portrait (no. 2 could have been the elder of Merkine Antanas Kazimieras Sapiega. The political realia of Grand Duchy of Lithuania (from now GDL are reflected by the heart shaped portrait of a youngster who we can guess is portrayed weeping over the countries misfortunes and internal disagreements duringthe period of foreight military interventions in the years from 1733 to 1736. It was forbiden for scribes to daub on court files and other official GDL documents therefore the discussed graffiti could be linked to psychological stress and

  1. Effect of hospital volume on processes of breast cancer care: A National Cancer Data Base study. (United States)

    Yen, Tina W F; Pezzin, Liliana E; Li, Jianing; Sparapani, Rodney; Laud, Purushuttom W; Nattinger, Ann B


    The purpose of this study was to examine variations in delivery of several breast cancer processes of care that are correlated with lower mortality and disease recurrence, and to determine the extent to which hospital volume explains this variation. Women who were diagnosed with stage I-III unilateral breast cancer between 2007 and 2011 were identified within the National Cancer Data Base. Multiple logistic regression models were developed to determine whether hospital volume was independently associated with each of 10 individual process of care measures addressing diagnosis and treatment, and 2 composite measures assessing appropriateness of systemic treatment (chemotherapy and hormonal therapy) and locoregional treatment (margin status and radiation therapy). Among 573,571 women treated at 1755 different hospitals, 38%, 51%, and 10% were treated at high-, medium-, and low-volume hospitals, respectively. On multivariate analysis controlling for patient sociodemographic characteristics, treatment year and geographic location, hospital volume was a significant predictor for cancer diagnosis by initial biopsy (medium volume: odds ratio [OR] = 1.15, 95% confidence interval [CI] = 1.05-1.25; high volume: OR = 1.30, 95% CI = 1.14-1.49), negative surgical margins (medium volume: OR = 1.15, 95% CI = 1.06-1.24; high volume: OR = 1.28, 95% CI = 1.13-1.44), and appropriate locoregional treatment (medium volume: OR = 1.12, 95% CI = 1.07-1.17; high volume: OR = 1.16, 95% CI = 1.09-1.24). Diagnosis of breast cancer before initial surgery, negative surgical margins and appropriate use of radiation therapy may partially explain the volume-survival relationship. Dissemination of these processes of care to a broader group of hospitals could potentially improve the overall quality of care and outcomes of breast cancer survivors. Cancer 2017;123:957-66. © 2016 American Cancer Society. © 2016 American Cancer Society.

  2. Preface: Biogeochemistry–ecosystem interaction on changing continental margins in the Anthropocene

    Digital Repository Service at National Institute of Oceanography (India)

    Liu, K-K.; Emeis, K.-C.; Levin, L.A.; Naqvi, S.W.A.; Roman, M.

    of the margin to marginal seas, continental shelves and slopes on the seaward side of the margin. Most importantly many case studies illustrate how human activities on land can impact far reaches of the margin. On the other hand, climate change and oscillations...

  3. Gas records from the West Greenland ice margin covering the Last Glacial termination: a horizontal ice core

    DEFF Research Database (Denmark)

    Petrenko, V.; Severinghaus, J.P.; Brook, E.J.


    Certain sites along ice sheet margins provide an easily accessible and almost unlimited supply of ancient ice at the surface. Measurements of gases in trapped air from ice outcropping at Pakitsoq, West Greenland, demonstrate that ancient air is mostly well preserved. No alterations in delta O-18......-uniformly thinned, with many cross-cutting bands of bubble-free ice and dust. The cross-cutting features are associated with anomalies in both the gas and the ice records. With careful sampling to avoid these, the ice at Pakitsoq is suitable for recovery of large-volume samples of the ancient atmosphere...

  4. Interpretation and attribute analysis of the S-reflector from Galicia Margin, offshore Spain (United States)

    Schuba, C. N.; Sawyer, D. S.; Gray, G. G.; Shillington, D. J.; Minshull, T. A.; Morgan, J.


    The majority of our understanding of rift evolution comes from passive continental margins and interpretations of their tectonic framework. The Galicia