High-volume ovarian cancer care: survival impact and disparities in access for advanced-stage disease.

Science.gov (United States)

Bristow, Robert E; Chang, Jenny; Ziogas, Argyrios; Randall, Leslie M; Anton-Culver, Hoda

2014-02-01

To characterize the impact of hospital and physician ovarian cancer case volume on survival for advanced-stage disease and investigate socio-demographic variables associated with access to high-volume providers. Consecutive patients with stage IIIC/IV epithelial ovarian cancer (1/1/96-12/31/06) were identified from the California Cancer Registry. Disease-specific survival analysis was performed using Cox-proportional hazards model. Multivariate logistic regression analyses were used to evaluate for differences in access to high-volume hospitals (HVH) (≥20 cases/year), high-volume physicians (HVP) (≥10 cases/year), and cross-tabulations of high- or low-volume hospital (LVH) and physician (LVP) according to socio-demographic variables. A total of 11,865 patients were identified. The median ovarian cancer-specific survival for all patients was 28.2 months, and on multivariate analysis the HVH/HVP provider combination (HR = 1.00) was associated with superior ovarian cancer-specific survival compared to LVH/LVP (HR = 1.31, 95%CI = 1.16-1.49). Overall, 2119 patients (17.9%) were cared for at HVHs, and 1791 patients (15.1%) were treated by HVPs. Only 4.3% of patients received care from HVH/HVP, while 53.1% of patients were treated by LVH/LVP. Both race and socio-demographic characteristics were independently associated with an increased likelihood of being cared for by the LVH/LVP combination and included: Hispanic race (OR = 1.72, 95%CI = 1.22-2.42), Asian/Pacific Islander race (OR = 1.57, 95%CI = 1.07-2.32), Medicaid insurance (OR = 2.51, 95%CI = 1.46-4.30), and low socioeconomic status (OR = 2.84, 95%CI = 1.90-4.23). Among patients with advanced-stage ovarian cancer, the provider combination of HVH/HVP is an independent predictor of improved disease-specific survival. Access to high-volume ovarian cancer providers is limited, and barriers are more pronounced for patients with low socioeconomic status, Medicaid insurance, and racial minorities. Copyright © 2013

BALTICA IV. Plant maintenance for managing life and performance

Energy Technology Data Exchange (ETDEWEB)

Hietanen, S; Auerkari, P [eds.; VTT Manufacturing Technology, Espoo (Finland). Operational Reliability

1999-12-31

BALTICA IV International Conference on Plant Maintenance Managing Life and performance held on September 7-9, 1998 on board M/S Silja Symphony on its cruise between Helsinki-Stockholm and at Aavaranta in Kirkkonummi. The BALTICA IV conference provides a forum for the transfer of technology from applied research to practice. This is one of the two volumes of the proceedings of the BALTICA IV International Conference on Plant Maintenance Managing Life and Performance. The BALTICA IV conference focuses on new technology, recent experience and applications of condition and life management, and on improvements in maintenance strategies for safe and economical operation of power plants. (orig.)

BALTICA IV. Plant maintenance for managing life and performance

Energy Technology Data Exchange (ETDEWEB)

Hietanen, S.; Auerkari, P. [eds.] [VTT Manufacturing Technology, Espoo (Finland). Operational Reliability

1998-12-31

BALTICA IV International Conference on Plant Maintenance Managing Life and performance held on September 7-9, 1998 on board M/S Silja Symphony on its cruise between Helsinki-Stockholm and at Aavaranta in Kirkkonummi. The BALTICA IV conference provides a forum for the transfer of technology from applied research to practice. This is one of the two volumes of the proceedings of the BALTICA IV International Conference on Plant Maintenance Managing Life and Performance. The BALTICA IV conference focuses on new technology, recent experience and applications of condition and life management, and on improvements in maintenance strategies for safe and economical operation of power plants. (orig.)

Deviations in expected price impact for small transaction volumes under fee restructuring

Science.gov (United States)

Harvey, M.; Hendricks, D.; Gebbie, T.; Wilcox, D.

2017-04-01

We report on the occurrence of an anomaly in the price impacts of small transaction volumes following a change in the fee structure of an electronic market. We first review evidence for the existence of a master curve for price impact on the Johannesburg Stock Exchange (JSE). On attempting to re-estimate a master curve after fee reductions, it is found that the price impact corresponding to smaller volume trades is greater than expected relative to prior estimates for a range of listed stocks. We show that a master curve for price impact can be found following rescaling by an appropriate liquidity proxy, providing a means for practitioners to approximate price impact curves without onerous processing of tick data.

The impact of whole human blood on the kinetic inertness of platinum(iv) prodrugs - an HPLC-ICP-MS study.

Science.gov (United States)

Theiner, Sarah; Grabarics, Márkó; Galvez, Luis; Varbanov, Hristo P; Sommerfeld, Nadine S; Galanski, Markus; Keppler, Bernhard K; Koellensperger, Gunda

2018-04-17

The potential advantage of platinum(iv) complexes as alternatives to classical platinum(ii)-based drugs relies on their kinetic stability in the body before reaching the tumor site and on their activation by reduction inside cancer cells. In this study, an analytical workflow has been developed to investigate the reductive biotransformation and kinetic inertness of platinum(iv) prodrugs comprising different ligand coordination spheres (respectively, lipophilicity and redox behavior) in whole human blood. The distribution of platinum(iv) complexes in blood pellets and plasma was determined by inductively coupled plasma-mass spectrometry (ICP-MS) after microwave digestion. An analytical approach based on reversed-phase (RP)-ICP-MS was used to monitor the parent compound and the formation of metabolites using two different extraction procedures. The ligand coordination sphere of the platinum(iv) complexes had a significant impact on their accumulation in red blood cells and on their degree of kinetic inertness in whole human blood. The most lipophilic platinum(iv) compound featuring equatorial chlorido ligands showed a pronounced penetration into blood cells and a rapid reductive biotransformation. In contrast, the more hydrophilic platinum(iv) complexes with a carboplatin- and oxaliplatin-core exerted kinetic inertness on a pharmacologically relevant time scale with notable amounts of the compound accumulated in the plasma fraction.

Research in collegiate mathematics education IV

CERN Document Server

Dubinsky, Ed; Kaput, Jim

2001-01-01

This fourth volume of Research in Collegiate Mathematics Education (RCME IV) reflects the themes of student learning and calculus. Included are overviews of calculus reform in France and in the U.S. and large-scale and small-scale longitudinal comparisons of students enrolled in first-year reform courses and in traditional courses. The work continues with detailed studies relating students' understanding of calculus and associated topics. Direct focus is then placed on instruction and student comprehension of courses other than calculus, namely abstract algebra and number theory. The volume co

Novel inhibitor of DNA ligase IV with a promising cancer therapeutic ...

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 39; Issue 3. Novel inhibitor of DNA ligase IV with a promising cancer therapeutic potential. Ashwin Kotnis Rita Mulherkar. Clipboards Volume 39 Issue 3 June 2014 pp 339-340. Fulltext. Click here to view fulltext PDF. Permanent link:

Astragaloside IV for Experimental Focal Cerebral Ischemia: Preclinical Evidence and Possible Mechanisms

Directory of Open Access Journals (Sweden)

Hui-Lin Wang

2017-01-01

Full Text Available Astragaloside IV (AST-IV is a principal component of Radix Astragali seu Hedysari (Huangqi and exerts potential neuroprotection in experimental ischemic stroke. Here, we systematically assessed the effectiveness and possible mechanisms of AST-IV for experimental acute ischemic stroke. An electronic search in eight databases was conducted from inception to March 2016. The study quality score was evaluated using the CAMARADES. Rev Man 5.0 software was used for data analyses. Thirteen studies with 244 animals were identified. The study quality score of included studies ranged from 3/10 to 8/10. Eleven studies showed significant effects of AST-IV for ameliorating the neurological function score (P<0.05; seven studies for reducing the infarct volume (P<0.05; and three or two studies for reducing the brain water content and Evans blue leakage (P<0.05, respectively, compared with the control. The mechanisms of AST-IV for ischemic stroke are multiple such as antioxidative/nitration stress reaction, anti-inflammatory, and antiapoptosis. In conclusion, the findings of present study indicated that AST-IV could improve neurological deficits and infarct volume and reduce the blood-brain barrier permeability in experimental cerebral ischemia despite some methodological flaws. Thus, AST-IV exerted a possible neuroprotective effect during the cerebral ischemia/reperfusion injury largely through its antioxidant, anti-inflammatory, and antiapoptosis properties.

DSM-IV disorders in children with borderline to moderate intellectual disability. I: Prevalence and impact. [IF 3.6

NARCIS (Netherlands)

Dekker, M.C.; Koot, H.M.

2003-01-01

Objective: To assess the prevalence, comorbidity, and impact of DSM-IV disorders in 7- to 20-year-olds with intellectual disability. Method: A total of 474 children (response 86.8%) were randomly selected from a sample of students from Dutch schools for the intellectually disabled. Parents completed

Impact of tumour volume on prediction of progression-free survival in sinonasal cancer

International Nuclear Information System (INIS)

Hennersdorf, Florian; Mauz, Paul-Stefan; Adam, Patrick; Welz, Stefan; Sievert, Anne; Ernemann, Ulrike; Bisdas, Sotirios

2015-01-01

The present study aimed to analyse potential prognostic factors, with emphasis on tumour volume, in determining progression free survival (PFS) for malignancies of the nasal cavity and the paranasal sinuses. Retrospective analysis of 106 patients with primary sinonasal malignancies treated and followed-up between March 2006 and October 2012. Possible predictive parameters for PFS were entered into univariate and multivariate Cox regression analysis. Kaplan-Meier curve analysis included age, sex, baseline tumour volume (based on MR imaging), histology type, TNM stage and prognostic groups according to the American Joint Committee on Cancer (AJCC) classification. Receiver operating characteristic (ROC) curve analysis concerning the predictive value of tumour volume for recurrence was also conducted. The main histological subgroup consisted of epithelial tumours (77%). The majority of the patients (68%) showed advanced tumour burden (AJCC stage III–IV). Lymph node involvement was present in 18 cases. The mean tumour volume was 26.6 ± 21.2 cm 3 . The median PFS for all patients was 24.9 months (range: 2.5–84.5 months). The ROC curve analysis for the tumour volume showed 58.1% sensitivity and 75.4% specificity for predicting recurrence. Tumour volume, AJCC staging, T- and N- stage were significant predictors in the univariate analysis. Positive lymph node status and tumour volume remained significant and independent predictors in the multivariate analysis. Radiological tumour volume proofed to be a statistically reliable predictor of PFS. In the multivariate analysis, T-, N- and overall AJCC staging did not show significant prognostic value

Impact of intra-arterial administration of boron compounds on dose-volume histograms in boron neutron capture therapy for recurrent head-and-neck tumors

International Nuclear Information System (INIS)

Suzuki, Minoru; Sakurai, Yoshinori; Nagata, Kenji; Kinashi, Yuko; Masunaga, Shinichiro; Ono, Koji; Maruhashi, Akira; Kato, Ituro; Fuwa, Nobukazu; Hiratsuka, Junichi; Imahori, Yoshio

2006-01-01

Purpose: To analyze the dose-volume histogram (DVH) of head-and-neck tumors treated with boron neutron capture therapy (BNCT) and to determine the advantage of the intra-arterial (IA) route over the intravenous (IV) route as a drug delivery system for BNCT. Methods and Materials: Fifteen BNCTs for 12 patients with recurrent head-and-neck tumors were included in the present study. Eight irradiations were done after IV administration of boronophenylalanine and seven after IA administration. The maximal, mean, and minimal doses given to the gross tumor volume were assessed using a BNCT planning system. Results: The results are reported as median values with the interquartile range. In the IA group, the maximal, mean, and minimal dose given to the gross tumor volume was 68.7 Gy-Eq (range, 38.8-79.9), 45.0 Gy-Eq (range, 25.1-51.0), and 13.8 Gy-Eq (range, 4.8-25.3), respectively. In the IV group, the maximal, mean, and minimal dose given to the gross tumor volume was 24.2 Gy-Eq (range, 21.5-29.9), 16.4 Gy-Eq (range, 14.5-20.2), and 7.8 Gy-Eq (range, 6.8-9.5), respectively. Within 1-3 months after BNCT, the responses were assessed. Of the 6 patients in the IV group, 2 had a partial response, 3 no change, and 1 had progressive disease. Of 4 patients in the IA group, 1 achieved a complete response and 3 a partial response. Conclusion: Intra-arterial administration of boronophenylalanine is a promising drug delivery system for head-and-neck BNCT

Electron impact excitation of Fe-peak elements: forbidden transitions in the 3d5 manifold of Fe IV

International Nuclear Information System (INIS)

McLaughlin, B M; Hibbert, A; Scott, M P; Noble, C J; Burke, V M; Burke, P G

2005-01-01

Electron-impact excitation collision strengths of the Fe-peak element Fe IV are calculated in the close-coupling approximation using the R-matrix suite of codes PRMAT designed for parallel processors. One hundred and eight LS-coupled states arising from the 3d 5 , 3d 4 4s and 3d 4 4p configurations of Fe IV, are retained in the present calculations. Detailed multi-configuration interaction target wavefunctions are used with the aid of 3p 2 → 3d 2 electron promotions and a 4dbar correlation orbital in the present calculations. Effective collision strengths for optically forbidden transitions, which are extremely important in the analysis of lines in the Fe IV spectra, are obtained by averaging the electron collision strengths for a wide range of incident electron energies, over a Maxwellian distribution of velocities. Results are presented for electron temperatures (T e in Kelvin) in the range 3.3 ≤ Log T e ≤ 6.0 applicable to many laboratory and astrophysical plasmas for transitions within the 3d 5 manifold. The present results compared to previous investigations provide improved results for important lines in the Fe IV spectrum

How the Change in IBS Criteria From Rome III to Rome IV Impacts on Clinical Characteristics and Key Pathophysiological Factors.

Science.gov (United States)

Aziz, Imran; Törnblom, Hans; Palsson, Olafur S; Whitehead, William E; Simrén, Magnus

2018-06-08

The diagnostic criteria for irritable bowel syndrome (IBS) have recently been updated from Rome III to Rome IV. Whereas in Rome III a diagnosis of IBS entailed chronic abdominal pain or discomfort at least 3 days per month, in Rome IV the term discomfort has been removed and the frequency of abdominal pain increased to at least 1 day per week. We examined how this change in IBS criteria impacts on clinical characteristics and pathophysiological factors. A total of 542 Swedish subjects with Rome III IBS completed a baseline questionnaire enquiring for the number of abdominal pain days in the last 10 days; this was subsequently used as a surrogate marker to identify Rome IV IBS, in that (a) those with 0 or 1 day of pain were classed as Rome IV-negative, and (b) those with ≥2 days of pain were classed as Rome IV-positive. Comparisons were made between Rome IV-positive and -negative IBS groups for demographics, IBS subtype, gastrointestinal and psychological symptoms, somatisation, fatigue, disease-specific quality of life, rectal sensitivity, and oro-anal transit time. Overall, 85% of Rome III IBS patients fulfilled the Rome IV criteria for IBS, but 15% did not. Rome IV-positive subjects were significantly more likely to be female, have poorer quality of life, greater pain severity, bloating, somatisation, fatigue, and rectal sensitivity than Rome IV-negative subjects. There were no differences in severity of anxiety or depression, IBS subtypes, bowel habit dissatisfaction, or oro-anal transit time. Finally, increasing number of pain days correlated positively with symptoms and visceral hypersensitivity. Most Rome III-positive IBS patients seeking healthcare fulfil the Rome IV IBS criteria. They constitute a more severe group than those who lose their IBS diagnosis.

Loading the Saturn I S-IV Stage into Pregnant Guppy

Science.gov (United States)

1965-01-01

The photograph shows the loading operation of the Saturn I S-IV stage (second stage) into the Pregnant Guppy at the Redstone Airfield, Huntsville, Alabama. The Pregnant Guppy was a Boeing B-377 Stratocruiser modified to transport various stages of Saturn launch vehicles. The modification project called for lengthening the fuselage to accommodate the S-IV stage. After the flight test of that modification, phase two called for the enlargement of the plane's cabin section to approximately double its normal volume. The fuselage separated just aft of the wing's trailing edge to load and unload the S-IV and other cargoes.

Economic impacts of Alberta's oil sands, volume 1

International Nuclear Information System (INIS)

Timilsina, G.R.; LeBlanc, N.; Walden, T.

2005-01-01

In 2004, the international media recognized Alberta's oil sands as part of the global oil reserves, thereby establishing Canada as second to Saudi Arabia as potential oil producing nations. The economic impacts of Alberta's oil sands industry on economies were assessed at regional, provincial and international levels for the 2000 to 2020 period. A customized input-output model was used to assess economic impacts, which were measured in terms of changes in gross domestic product; employment and labour income; and, government revenues. Cumulative impacts on employment by sector and by jurisdiction were also presented. An investment of $100 billion is expected through 2020, resulting in production of crude bitumen and synthetic crude oil outputs valued at about $531 billion. The impact of the oil sands industry on local employment was also evaluated. It was shown that activities in the oil sands industry will lead to significant economic impact in Alberta, Ontario, Quebec and the rest of Canada. Alberta's local economy would be the main beneficiary of oil sands activities with nearly 3.6 million person years employment created in Alberta during the 2000 to 2020. Another 3 million person years employment would be created in other Canadian provinces and outside Canada during the same time period. A sensitivity analysis on the responsiveness to oil prices and the removal of various constraints incorporated in the main analysis was also presented. The federal government will be the largest recipient of revenues generated to to oil sands activities. The results of the study were compared with that of the National Task Force on Oil Sands Strategies. This first volume revealed the results of the study while the second volume includes the data and detailed results. 48 refs., 57 tabs., 28 figs

Potential impacts of OCS oil and gas activities on fisheries. Volume 2. Annotated bibliography for OCS oil and gas impact studies. Final report

International Nuclear Information System (INIS)

Tear, L.M.

1989-10-01

The volume is the second of two volumes to the final report, Potential Impacts of OCS Oil and Gas Activities on Fisheries. The volume presents an annotated bibliography of published and grey literature related to OCS oil and gas activity impacts of finfish and shellfish in marine and estuaring waters. The studies presented in the bibliography include those related to the following pollutants or impact-causing activities: Rig/reef effects, Drilling discharges (muds or cuttings), Oil (petroleum hydrocarbons), Trace metals, Produced water, Habitat alteration, Debris, Rig placement (avoidance), Pipelines, and Socioeconomic effects. The studies are listed alphabetically by the primary author's last name. An index is provided to help the reader identify studies related to a specific impact

Internet Economics IV

Science.gov (United States)

2004-08-01

edts.): Internet Economics IV Technical Report No. 2004-04, August 2004 Information Systems Laboratory IIS, Departement of Computer Science University of...level agreements (SLA), Information technology (IT), Internet address, Internet service provider 16. PRICE CODE 17. SECURITY CLASSIFICATION 18... technology and its economic impacts in the Internet world today. The second talk addresses the area of AAA protocol, summarizing authentication

Generation IV Nuclear Energy Systems Ten-Year Program Plan Fiscal Year 2005, Volume 1

International Nuclear Information System (INIS)

None

2005-01-01

As reflected in the U.S. ''National Energy Policy'', nuclear energy has a strong role to play in satisfying our nation's future energy security and environmental quality needs. The desirable environmental, economic, and sustainability attributes of nuclear energy give it a cornerstone position, not only in the U.S. energy portfolio, but also in the world's future energy portfolio. Accordingly, on September 20, 2002, U.S. Energy Secretary Spencer Abraham announced that, ''The United States and nine other countries have agreed to develop six Generation IV nuclear energy concepts''. The Secretary also noted that the systems are expected to ''represent significant advances in economics, safety, reliability, proliferation resistance, and waste minimization''. The six systems and their broad, worldwide research and development (R and D) needs are described in ''A Technology Roadmap for Generation IV Nuclear Energy Systems'' (hereafter referred to as the Generation IV Roadmap). The first 10 years of required U.S. R and D contributions to achieve the goals described in the Generation IV Roadmap are outlined in this Program Plan

The impacts of the rise of Paragraph IV challenges on startup alliance formation and firm value in the pharmaceutical industry.

Science.gov (United States)

Filson, Darren; Oweis, Ahmed

2010-07-01

Court decisions in 1998 encouraged generic producers to pursue Paragraph IV patent challenges. A follow-up decision in 2000 marked the first successful challenge involving a blockbuster and brought further attention to this pathway for generic entry. We consider the impacts of these decisions on R&D-based startups, and we focus on the propensity to form alliances as a primary channel of impact. We find substantial negative impacts on alliance formation and firm value, and only the first event's impacts are restricted to small molecules. The results suggest that policy analyses in settings with R&D-based startups should consider impacts on alliance formation.

A theoretical approach to the problem of dose-volume constraint estimation and their impact on the dose-volume histogram selection

International Nuclear Information System (INIS)

Schinkel, Colleen; Stavrev, Pavel; Stavreva, Nadia; Fallone, B. Gino

2006-01-01

This paper outlines a theoretical approach to the problem of estimating and choosing dose-volume constraints. Following this approach, a method of choosing dose-volume constraints based on biological criteria is proposed. This method is called ''reverse normal tissue complication probability (NTCP) mapping into dose-volume space'' and may be used as a general guidance to the problem of dose-volume constraint estimation. Dose-volume histograms (DVHs) are randomly simulated, and those resulting in clinically acceptable levels of complication, such as NTCP of 5±0.5%, are selected and averaged producing a mean DVH that is proven to result in the same level of NTCP. The points from the averaged DVH are proposed to serve as physical dose-volume constraints. The population-based critical volume and Lyman NTCP models with parameter sets taken from literature sources were used for the NTCP estimation. The impact of the prescribed value of the maximum dose to the organ, D max , on the averaged DVH and the dose-volume constraint points is investigated. Constraint points for 16 organs are calculated. The impact of the number of constraints to be fulfilled based on the likelihood that a DVH satisfying them will result in an acceptable NTCP is also investigated. It is theoretically proven that the radiation treatment optimization based on physical objective functions can sufficiently well restrict the dose to the organs at risk, resulting in sufficiently low NTCP values through the employment of several appropriate dose-volume constraints. At the same time, the pure physical approach to optimization is self-restrictive due to the preassignment of acceptable NTCP levels thus excluding possible better solutions to the problem

Infusion volume control and calculation using metronome and drop counter based intravenous infusion therapy helper.

Science.gov (United States)

Park, Kyungnam; Lee, Jangyoung; Kim, Soo-Young; Kim, Jinwoo; Kim, Insoo; Choi, Seung Pill; Jeong, Sikyung; Hong, Sungyoup

2013-06-01

This study assessed the method of fluid infusion control using an IntraVenous Infusion Controller (IVIC). Four methods of infusion control (dial flow controller, IV set without correction, IV set with correction and IVIC correction) were used to measure the volume of each technique at two infusion rates. The infused fluid volume with a dial flow controller was significantly larger than other methods. The infused fluid volume was significantly smaller with an IV set without correction over time. Regarding the concordance correlation coefficient (CCC) of infused fluid volume in relation to a target volume, IVIC correction was shown to have the highest level of agreement. The flow rate measured in check mode showed a good agreement with the volume of collected fluid after passing through the IV system. Thus, an IVIC could assist in providing an accurate infusion control. © 2013 Wiley Publishing Asia Pty Ltd.

Shatavarins (containing Shatavarin IV) with anticancer activity from the roots of Asparagus racemosus

Science.gov (United States)

Mitra, Shankar K.; Prakash, Neswi S.; Sundaram, Ramachandran

2012-01-01

Objectives: The anticancer activity of shatavarins (containing shatavarin IV) isolated from the roots of Asparagus racemosus (Wild) was evaluated using in vitro and in vivo experimental models. Material and Methods: The shatavarin IV was isolated from ethyl acetate insoluble fraction (AR-2B) of chloroform:methanol (2:1) (AR-2) extract of A. racemosus roots. The cytotoxicity (in vitro) of shatavarin IV and other shatavarins rich fraction was carried out using of MTT assay using MCF-7 (human breast cancer), HT-29 (human colon adenocarcinoma), and A-498 (human kidney carcinoma) cell lines. The in vivo anticancer activity of shatavarins (containing shatavarin IV) was evaluated against Ehrlich ascites carcinoma (EAC) tumor bearing mice. Results: The isolated shatavarin IV (84.69 %) along with shatavarins rich fraction, coded AR-2B containing 5.05% shatavarin IV showed potent cytotoxicity. Oral administration of AR-2B to tumor bearing mice at doses of 250 and 500 mg/kg body weight for 10 days, showed significant reduction in percent increase in body weight, tumor volume, packed cell volume, viable tumor cell count, and increased non-viable cell count when compared to the untreated mice of the EAC control group. The restoration of hematological parameters towards normalcy was also observed. Conclusion: The result suggests that the shatavarins (containing shatavarin IV) rich fraction (AR-2B) exhibits significant anticancer activity in both in vitro and in vivo experimental models. PMID:23248403

New Internet search volume-based weighting method for integrating various environmental impacts

Energy Technology Data Exchange (ETDEWEB)

Ji, Changyoon, E-mail: changyoon@yonsei.ac.kr; Hong, Taehoon, E-mail: hong7@yonsei.ac.kr

2016-01-15

Weighting is one of the steps in life cycle impact assessment that integrates various characterized environmental impacts as a single index. Weighting factors should be based on the society's preferences. However, most previous studies consider only the opinion of some people. Thus, this research proposes a new weighting method that determines the weighting factors of environmental impact categories by considering public opinion on environmental impacts using the Internet search volumes for relevant terms. To validate the new weighting method, the weighting factors for six environmental impacts calculated by the new weighting method were compared with the existing weighting factors. The resulting Pearson's correlation coefficient between the new and existing weighting factors was from 0.8743 to 0.9889. It turned out that the new weighting method presents reasonable weighting factors. It also requires less time and lower cost compared to existing methods and likewise meets the main requirements of weighting methods such as simplicity, transparency, and reproducibility. The new weighting method is expected to be a good alternative for determining the weighting factor. - Highlight: • A new weighting method using Internet search volume is proposed in this research. • The new weighting method reflects the public opinion using Internet search volume. • The correlation coefficient between new and existing weighting factors is over 0.87. • The new weighting method can present the reasonable weighting factors. • The proposed method can be a good alternative for determining the weighting factors.

New Internet search volume-based weighting method for integrating various environmental impacts

International Nuclear Information System (INIS)

Ji, Changyoon; Hong, Taehoon

2016-01-01

Weighting is one of the steps in life cycle impact assessment that integrates various characterized environmental impacts as a single index. Weighting factors should be based on the society's preferences. However, most previous studies consider only the opinion of some people. Thus, this research proposes a new weighting method that determines the weighting factors of environmental impact categories by considering public opinion on environmental impacts using the Internet search volumes for relevant terms. To validate the new weighting method, the weighting factors for six environmental impacts calculated by the new weighting method were compared with the existing weighting factors. The resulting Pearson's correlation coefficient between the new and existing weighting factors was from 0.8743 to 0.9889. It turned out that the new weighting method presents reasonable weighting factors. It also requires less time and lower cost compared to existing methods and likewise meets the main requirements of weighting methods such as simplicity, transparency, and reproducibility. The new weighting method is expected to be a good alternative for determining the weighting factor. - Highlight: • A new weighting method using Internet search volume is proposed in this research. • The new weighting method reflects the public opinion using Internet search volume. • The correlation coefficient between new and existing weighting factors is over 0.87. • The new weighting method can present the reasonable weighting factors. • The proposed method can be a good alternative for determining the weighting factors.

PRT Impact Study Pre-PRT Phase : Volume 1. Travel Analysis.

Science.gov (United States)

1976-03-01

Part of a three-volume work, this report describes the analysis performed on travel data collected for the Pre-PRT Impact Study. The data analyzed consist of travel behavior, travel patterns, model utilization and travel costs of various modes of tra...

Uranium milling, project M-25. Volume I. summary and text. Final generic environmental impact statement

International Nuclear Information System (INIS)

1980-09-01

The Final Generic Environmental Impact Statement (GEIS) on Uranium Milling focuses primarily upon the matter of mill tailings disposal. It evaluates both the costs and benefits of alternative tailings disposal modes and draws conclusions about criteria which should be incorporated into regulations. Both institutional and technical controls are evaluated. Health impacts considered were both short and long term. Restatement and resolution of all public comments received on the draft (GEIS) are presented. There are three volumes: Volume I is the main text and Volumes II and III are supporting appendices

Impact of the time window on plasma volume measurement with indocyanine green

International Nuclear Information System (INIS)

Jacob, M; Chappell, D; Conzen, P; Finsterer, U; Rehm, M; Krafft, A; Becker, B F

2008-01-01

Recent reports have questioned the accuracy of the indocyanine green dilution technique for measuring plasma volume. Our objective was to evaluate the impact of different time windows for monoexponential extrapolation. We retrospectively analysed 31 indocyanine green decay curves to investigate the problem in principle (group 1) and prospectively performed another 21 plasma volume measurements to estimate its practical impact (group 2). To monoexponentially extrapolate back to the specific extinction at the time of dye injection, two different time windows were applied to each decay curve, comparing the plasma volumes resulting from sampling within a short (≤5 min) versus a longer (>5 min) period of time. Extrapolating back from the longer period led to a higher apparent plasma volume relative to the shorter period in both groups, the difference being 348 ± 171 ml (group 1) and 384 ± 131 ml (group 2; mean ± SD; p < 0.05 each). This result was due to a reliable monoexponentiality of decay only up to the 5th min after dye injection. Thus, to estimate the initial distribution space of indocyanine green via monoexponential extrapolation, the first linear kinetic of indocyanine green decay should be taken

Coal use in the People's Republic of China. Volume 1: Environmental impacts

International Nuclear Information System (INIS)

Bhatti, N.; Tompkins, M.M.; Simbeck, D.R.

1994-11-01

The People's Republic of China (hereafter referred to as China) is the largest producer and consumer of coal in the world. Coal makes up 76% and 74% of China's primary energy consumption and production, respectively. This heavy dependence on coal has come at a high price for China, accounting for a large share of its environmental problems. This report examines the dominance of coal in China's energy balance, its impact on the environment, and the need for technical and financial assistance, specifically for two distinct aspects: the effect of coal use on the environment and the importance of coal to China's economy. The results of the analysis are presented in two volumes. Volume 1 focuses on full fuel cycle coal emissions and the environmental effects of coal consumption. Volume 2 provides a detailed analysis by sector of China's economy and examines the economic impact of constraints on coal use. 51 refs., 19 figs., 15 tabs

Impact of Business Education in Enhancing Sales Volumes of Retail ...

African Journals Online (AJOL)

This study investigated the impact of business education in enhancing sales volume of retail business in Ohaozara local Government Area of Ebonyi State. Ninety (90) respondents formed the population of study. The instrument of data collection was a well structured and pretested questionnaire. Two research questions ...

Hepatic imaging in stage IV-S neuroblastoma

International Nuclear Information System (INIS)

Franken, E.A. Jr.; Smith, W.L.; Iowa Univ., Iowa City; Cohen, M.D.; Kisker, C.T.; Platz, C.E.

1986-01-01

Stage IV-S neuroblastoma describes a group of infants with tumor spread limited to liver, skin, or bone marrow. Such patients, who constitute about 25% of affected infants with neuroblastoma, may expect spontaneous tumor remission. We report 18 infants with Stage IV-S neuroblastoma, 83% of whom had liver involvement. Imaging investigations included Technetium 99m sulfur colloid scan, ultrasound, and CT. Two patterns of liver metastasis were noted: ill-defined nodules or diffuse tumor throughout the liver. Distinction of normal and abnormal liver with diffuse type metastasis could be quite difficult, particularly with liver scans. We conclude that patients with Stage IV-S neuroblastoma have ultrasound or CT examination as an initial workup, with nuclear medicine scans reserved for followup studies. (orig.)

Thermodynamic data for predicting concentrations of Th(IV), U(IV), Np(IV), and Pu(IV) in geologic environments

Energy Technology Data Exchange (ETDEWEB)

Rai, Dhanpat; Roa, Linfeng; Weger, H.T.; Felmy, A.R. [Battelle, Pacific Northwest National Laboratory (PNNL) (United States); Choppin, G.R. [Florida State University (United States); Yui, Mikazu [Waste Isolation Research Division, Tokai Works, Japan Nuclear Cycle Development Inst., Tokai, Ibaraki (Japan)

1999-01-01

This report provides thermodynamic data for predicting concentrations of Th(IV), U(IV), Np(IV), and Pu(IV) in geologic environments, and contributes to an integration of the JNC chemical thermodynamic database, JNC-TDB (previously PNC-TDB), for the performance analysis of geological isolation system for high-level radioactive wastes. Thermodynamic data for the formation of complexes or compounds with hydroxide, chloride, fluoride, carbonate, nitrate, sulfate and phosphate are discussed in this report. Where data for specific actinide(IV) species was lacking, the data were selected based on chemical analogy to other tetravalent actinides. In this study, the Pitzer ion-interaction model is used to extrapolate thermodynamic constants to zero ionic strength at 25degC. (author)

About the structure and stability of complex carbonates of thorium (IV), cerium (IV), zirconium (IV), hafnium (IV)

International Nuclear Information System (INIS)

Dervin, Jacqueline

1972-01-01

This research thesis addressed the study of complex carbonates of cations of metals belonging to the IV A column, i.e. thorium (IV), zirconium (IV), hafnium (IV), and also cerium (IV) and uranium (VI), and more particularly focused on ionic compounds formed in solution, and also on the influence of concentration and nature of cations on stability and nature of the formed solid. The author first presents methods used in this study, discusses their precision and scope of validity. She reports the study of the formation of different complex ions which have been highlighted in solution, and the determination of their formation constants. She reports the preparation and study of the stability domain of solid complexes. The next part reports the use of thermogravimetric analysis, IR spectrometry, and crystallography for the structural study of these compounds

Analysis of Phoenix Anomalies and IV and V Findings Applied to the GRAIL Mission

Science.gov (United States)

Larson, Steve

2012-01-01

Analysis of patterns in IV&V findings and their correlation with post-launch anomalies allowed GRAIL to make more efficient use of IV&V services . Fewer issues. . Higher fix rate. . Better communication. . Increased volume of potential issues vetted, at lower cost. . Hard to make predictions of post-launch performance based on IV&V findings . Phoenix made sound fix/use as-is decisions . Things that were fixed eliminated some problems, but hard to quantify. . Broad predictive success in one area, but inverse relationship in others.

Survey of fish impingement at power plants in the United States. Volume I. The Great Lakes

International Nuclear Information System (INIS)

Sharma, R.K.; Freeman, R.F. III.

1977-03-01

Impingement of fish at cooling-water intakes of 20 power plants located on the Great Lakes has been surveyed and data are presented. Descriptions of site, plant, and intake design and operation are provided. Reports in this volume summarize impingement data for individual plants in tabular and histogram formats. Information was available from differing sources such as the utilities themselves, public documents, regulatory agencies, and others. Thus, the extent of detail in the reports varies greatly from plant to plant. Histogram preparation involved an extrapolation procedure that has inadequacies. The reader is cautioned in the use of information presented in this volume to determine intake-design acceptability or intensity of impacts on ecosystems. No conclusions are presented herein; data comparisons are made in Volume IV

Prevalence of DSM-IV disorders in a population-based sample of 5- to 8-year-old children : the impact of impairment criteria

NARCIS (Netherlands)

Rijlaarsdam, Jolien; Stevens, Gonneke W J M; van der Ende, Jan; Hofman, Albert; Jaddoe, Vincent W V; Verhulst, Frank C.; Tiemeier, Henning

2015-01-01

This study determined the impact of impairment criteria on the prevalence and patterns of comorbidity of child DSM-IV disorders. The validity of these impairment criteria was tested against different measures of mental health care referral and utilization. We interviewed parents of 1,154 children

Prevalence of DSM-IV disorders in a population-based sample of 5- to 8-year-old children: the impact of impairment criteria

NARCIS (Netherlands)

J. Rijlaarsdam (Jolien); G. Stevens (Gonneke); J. van der Ende (Jan); A. Hofman (Albert); V.W.V. Jaddoe (Vincent); F.C. Verhulst (Frank); H.W. Tiemeier (Henning)

2015-01-01

textabstractThis study determined the impact of impairment criteria on the prevalence and patterns of comorbidity of child DSM-IV disorders. The validity of these impairment criteria was tested against different measures of mental health care referral and utilization. We interviewed parents of 1,154

Grading of vestibular schwannomas and corresponding tumor volumes: ramifications for radiosurgery.

Science.gov (United States)

Mindermann, T; Schlegel, I

2013-01-01

Patients with vestibular schwannomas (VS) are either assigned to watchful waiting, microsurgical resection, or radiosurgery. Decision making on how to proceed is based on parameters such as age, tumor growth, loss of hearing, and the tumor's Koos grading. In order to correlate Koos grading with tumor volume, patient records of 235 patients with VS who underwent Gamma Knife radiosurgery (GKRS) were retrospectively reviewed. From 1994 to 2009, 235 consecutive patients underwent GKRS for sporadic VS at the Zurich Gamma Knife Center. Median follow up was 62.8 ± 33.0 months. Of the 235 tumors, 32 (13.6 %) were graded Koos I with a volume of 0.25 ± 0.3 cc; 71 (30.2 %) were graded Koos II with a volume of 0.57 ± 0.54 cc; 70 (29.8 %) were graded Koos III with a volume of 1.82 ± 1.88 cc; and 62 (26.4 %) were graded Koos IV with a volume of 4.17 ± 2.75 cc. Tumor progression was defined as a volume increase > 20 % at 2 years or later following GKRS. Overall tumor progression occurred in 21/235 (8.9 %) patients at 3.4 ± 0.9 years. Tumor progression did not differ statistically significantly in the various Koos grades: 1/32 (3.1 %) patients with VS Koos Grade I, 7/71 (9.8 %) patients with VS Koos Grade II, 6/70 (8.6 %) patients with VS Koos Grade III, and 7/62 (11.3 %) patients with VS Koos Grade IV. To our knowledge, this is the first work correlating the various Koos grades of VS to their respective tumor volumes. In our patients, tumor volumes of VS Koos Grade IV were limited because all of our patients were eligible for radiosurgery. In our series, the outcome following GKRS for patients with VS Koos Grade IV tumors did not differ from patients with VS Koos Grades I-III. We therefore suggest to limit Koos Grade IV VS to tumor volumes 6 cc that may not be eligible for radiosurgery.

Survey of fish impingement at power plants in the United States. Volume II. Inland waters

International Nuclear Information System (INIS)

Freeman, R.F. III; Sharma, R.K.

1977-03-01

Impingement of fish at cooling-water intakes of 33 power plants located on inland waters other than the Great Lakes has been surveyed and data are presented. Descriptions of site, plant, and intake design and operation are provided. Reports in this volume summarize impingement data for individual plants in tabular and histogram formats. Information was available from differing sources such as the utilities themselves, public documents, regulatory agencies, and others. Thus, the extent of detail in the reports varies greatly from plant to plant. Histogram preparation involved an extrapolation procedure that has inadequacies. The reader is cautioned in the use of information presented in this volume to determine intake-design acceptability or intensity of impacts on ecosystems. No conclusions are presented herein; data comparisons are made in Volume IV

Survey of fish impingement at power plants in the United States. Volume III. Estuaries and coastal waters

International Nuclear Information System (INIS)

Stupka, R.C.; Sharma, R.K.

1977-03-01

Impingement of fish at cooling-water intakes of 32 power plants, located on estuaries and coastal waters has been surveyed and data are presented. Descriptions of site, plant, and intake design and operation are provided. Reports in this volume summarize impingement data for individual plants in tabular and histogram formats. Information was available from differing sources such as the utilities themselves, public documents, regulatory agencies, and others. Thus, the extent of detail in the reports varies greatly from plant to plant. Histogram preparation involved an extrapolation procedure that has inadequacies. The reader is cautioned in the use of information presented in this volume to determine intake-design acceptability or intensity of impacts on ecosystems. No conclusions are presented herein; data comparisons are made in Volume IV

Survey of fish impingement at power plants in the United States. Volume III. Estuaries and coastal waters

Energy Technology Data Exchange (ETDEWEB)

Stupka, Richard C.; Sharma, Rajendra K.

1977-03-01

Impingement of fish at cooling-water intakes of 32 power plants, located on estuaries and coastal waters has been surveyed and data are presented. Descriptions of site, plant, and intake design and operation are provided. Reports in this volume summarize impingement data for individual plants in tabular and histogram formats. Information was available from differing sources such as the utilities themselves, public documents, regulatory agencies, and others. Thus, the extent of detail in the reports varies greatly from plant to plant. Histogram preparation involved an extrapolation procedure that has inadequacies. The reader is cautioned in the use of information presented in this volume to determine intake-design acceptability or intensity of impacts on ecosystems. No conclusions are presented herein; data comparisons are made in Volume IV.

The fourth Arab Impact Cratering and Astrogeology Conference (AICAC IV), April 9-12, 2017, Algiers (Algeria)

Science.gov (United States)

Belhaï, D.; Chennaoui-Aoudjehane, H.; Baratoux, D.; Ferrière, L.; Lamali, A.; Sahoui, R.; Lambert, P.; Ayadi, A.

2017-09-01

We present a report about the fourth Arab Impact Cratering and Astrogeology Conference (AICAC IV) that took place in Algiers at the USTHB (Université des Sciences et Technologie Houari Boumedienne, Algiers, Algeria) in the presence of the presidents of the USTHB and Boumerdès Universities, the Director of CRAAG (Centre de Recherche en Astronomie, Astrophysique et Géophysique), and the General Director of the National Administration for Scientific Research (NASR/DGRSDT). This series of conferences aims to promote research interest for impact cratering in the Arab world and beyond, including for instance in African countries. In spite of persistently restraining travel measures to Algeria, the fourth edition held in Algiers was marked by continuous international participation, with participants from seven different countries. This conference focused on presentations of scientific results in the research fields related to planetology, meteorites, and impact craters. In particular, the Algerian impact structures were under the spotlights during both oral and poster sessions. During this conference, the presence of freshly graduated Ph.D. students and new Ph.D. projects related to impact cratering or meteoritic science was a positive sign for the consolidation of research groups in this domain in the Arab world and Africa. Therefore, international cooperation or external support and funding are still needed to ensure the development of this scientific discipline in this part of the world.

Pore Structure and Fluoride Ion Adsorption Characteristics of Zr (IV) Surface-Immobilized Resin Prepared Using Polystyrene as a Porogen

Science.gov (United States)

Mizuki, Hidenobu; Ito, Yudai; Harada, Hisashi; Uezu, Kazuya

Zr(IV) surface-immobilized resins for removal of fluoride ion were prepared by surface template polymerization using polystyrene as a porogen. At polymerization, polystyrene was added in order to increase mesopores (2-50 nm) and macropore (>50 nm) with large macropores (around 300 nm) formed with internal aqueous phase of W⁄O emulsion. The pore structure of Zr(IV) surface-immobilized resins was evaluated by measuring specific surface area, pore volume, and pore size distribution with volumetric adsorption measurement instrument and mercury porosimeter. The adsorption isotherms were well fitted by Langmuir equation. The removal of fluoride was also carried out with column method. Zr(IV) surface-immobilized resins, using 10 g⁄L polystyrene in toluene at polymerization, possessed higher volume of not only mesopores and macropores but also large macropores. Furethermore, by adding the polystyrene with smaller molecular size, the pore volume of mesopores, macropores and large macropores was significantly increased, and the fluoride ion adsorption capacity and the column utilization also increased.

A new approach to treatment of resistant gram-positive infections: potential impact of targeted IV to oral switch on length of stay

Directory of Open Access Journals (Sweden)

Trust Sarah

2006-06-01

Full Text Available Abstract Background Patients prescribed intravenous (IV glycopeptides usually remain in hospital until completion of this treatment. Some of these patients could be discharged earlier if a switch to an oral antibiotic was made. This study was designed to identify the percentage of inpatients currently prescribed IV glycopeptides who could be discharged earlier if a switch to an oral agent was used, and to estimate the number of bed days that could be saved. We also aimed to identify the patient group(s most likely to benefit, and to estimate the number of days of IV therapy that could be prevented in patients who remained in hospital. Methods Patients were included if they were prescribed an IV glycopeptide for 5 days or more. Predetermined IV to oral antibiotic switch criteria and discharge criteria were applied. A multiple logistic regression model was used to identify the characteristics of the patients most likely to be suitable for earlier discharge. Results Of 211 patients, 62 (29% could have had a reduced length of stay if they were treated with a suitable oral antibiotic. This would have saved a total of 649 inpatient days (median 5 per patient; range 1–54. A further 31 patients (15% could have switched to oral therapy as an inpatient thus avoiding IV line use. The patients most likely to be suitable for early discharge were those with skin and soft tissue infection, under the cardiology, cardiothoracic surgery, orthopaedics, general medical, plastic surgery and vascular specialities, with no high risk comorbidity and less than five other regularly prescribed drugs. Conclusion The need for glycopeptide therapy has a significant impact on length of stay. Effective targeting of oral antimicrobials could reduce the need for IV access, allow outpatient treatment and thus reduce the length of stay in patients with infections caused by antibiotic resistant gram-positive bacteria.

Impacts of Outer Continental Shelf (OCS) development on recreation and tourism. Volume 3. Detailed methodology

Energy Technology Data Exchange (ETDEWEB)

1987-04-01

The final report for the project is presented in five volumes. This volume, Detailed Methodology Review, presents a discussion of the methods considered and used to estimate the impacts of Outer Continental Shelf (OCS) oil and gas development on coastal recreation in California. The purpose is to provide the Minerals Management Service with data and methods to improve their ability to analyze the socio-economic impacts of OCS development. Chapter II provides a review of previous attempts to evaluate the effects of OCS development and of oil spills on coastal recreation. The review also discusses the strengths and weaknesses of different approaches and presents the rationale for the methodology selection made. Chapter III presents a detailed discussion of the methods actually used in the study. The volume contains the bibliography for the entire study.

Temporal Lobe Reactions After Carbon Ion Radiation Therapy: Comparison of Relative Biological Effectiveness–Weighted Tolerance Doses Predicted by Local Effect Models I and IV

Energy Technology Data Exchange (ETDEWEB)

Gillmann, Clarissa, E-mail: clarissa.gillmann@med.uni-heidelberg.de [Department of Radiation Oncology and Radiation Therapy, Heidelberg University Hospital, Heidelberg (Germany); Jäkel, Oliver [Department of Radiation Oncology and Radiation Therapy, Heidelberg University Hospital, Heidelberg (Germany); Heidelberg Ion Beam Therapy Center (HIT), Heidelberg (Germany); Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg (Germany); Schlampp, Ingmar [Department of Radiation Oncology and Radiation Therapy, Heidelberg University Hospital, Heidelberg (Germany); Karger, Christian P. [Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg (Germany)

2014-04-01

Purpose: To compare the relative biological effectiveness (RBE)–weighted tolerance doses for temporal lobe reactions after carbon ion radiation therapy using 2 different versions of the local effect model (LEM I vs LEM IV) for the same patient collective under identical conditions. Methods and Materials: In a previous study, 59 patients were investigated, of whom 10 experienced temporal lobe reactions (TLR) after carbon ion radiation therapy for low-grade skull-base chordoma and chondrosarcoma at Helmholtzzentrum für Schwerionenforschung (GSI) in Darmstadt, Germany in 2002 and 2003. TLR were detected as visible contrast enhancements on T1-weighted MRI images within a median follow-up time of 2.5 years. Although the derived RBE-weighted temporal lobe doses were based on the clinically applied LEM I, we have now recalculated the RBE-weighted dose distributions using LEM IV and derived dose-response curves with Dmax,V-1 cm³ (the RBE-weighted maximum dose in the remaining temporal lobe volume, excluding the volume of 1 cm³ with the highest dose) as an independent dosimetric variable. The resulting RBE-weighted tolerance doses were compared with those of the previous study to assess the clinical impact of LEM IV relative to LEM I. Results: The dose-response curve of LEM IV is shifted toward higher values compared to that of LEM I. The RBE-weighted tolerance dose for a 5% complication probability (TD{sub 5}) increases from 68.8 ± 3.3 to 78.3 ± 4.3 Gy (RBE) for LEM IV as compared to LEM I. Conclusions: LEM IV predicts a clinically significant increase of the RBE-weighted tolerance doses for the temporal lobe as compared to the currently applied LEM I. The limited available photon data do not allow a final conclusion as to whether RBE predictions of LEM I or LEM IV better fit better clinical experience in photon therapy. The decision about a future clinical application of LEM IV therefore requires additional analysis of temporal lobe reactions in a

Dosimetric impact of the variation of the prostate volume and shape between pretreatment planning and treatment procedure

International Nuclear Information System (INIS)

Beaulieu, Luc; Aubin, Sylviane; Taschereau, Richard; Pouliot, Jean; Vigneault, Eric

2002-01-01

Purpose: The goal of this study is to evaluate the dosimetric impact on a pretreatment planning of prostatic volume and shape variations occurring between the moment of the volume study (preplanning) and just before a transperineal permanent seed implant procedure. Such variations could be an obvious source of misplacement of the seeds relative to the prostate gland and organs at risk. Other sources of dosimetric uncertainties, such as misplacement due to the procedure itself or edema, are eliminated by looking at these variations before the implant procedure. Methods and Materials: For 35 clinical cases, prostate contours were taken at preplanning time as well as in the operating room (OR) minutes before the procedure. Comparison of shape and volume between the two sets was made. The impact on V100 was evaluated by placing the seeds in their planned positions in the new volume (clinical situation) and also by performing a new plan with the second set of contours to simulate an intraoperative approach. Results: The volume taken in the OR remained unchanged compared to the pretreatment planning volume in only 37% of the cases. While on average the dose coverage loss from pretreatment planning due to a combination of variations of volume and shape was small at 5.7%, a V100 degradation of up to 20.9% was observed in extreme cases. Even in cases in which no changes in volume were observed, changes in shape occurred and strongly affected implant dosimetry. Conclusions: Variations of volume and shape between pretreatment planning and the implant procedure can have a strong impact on the dosimetry if the planning and the implant procedure are not performed on the same day. This is an argument in favor of performing implant dosimetry in the OR

MACKLIB-IV: a library of nuclear response functions generated with the MACK-IV computer program from ENDF/B-IV

International Nuclear Information System (INIS)

Gohar, Y.; Abdou, M.A.

1978-03-01

MACKLIB-IV employs the CTR energy group structure of 171 neutron groups and 36 gamma groups. A retrieval computer program is included with the library to permit collapsing into any other energy group structure. The library is in the new format of the ''MACK-Activity Table'' which uses a fixed position for each specific response function. This permits the user when employing the library with present transport codes to obtain directly the nuclear responses (e.g. the total nuclear heating) summed for all isotopes and integrated over any geometrical volume. The response functions included in the library are neutron kerma factor, gamma kerma factor, gas production and tritium-breeding functions, and all important reaction cross sections. Pertinent information about the library and a graphical display of six response functions for all materials in the library are given

Taper-based system for estimating stem volumes of upland oaks

Science.gov (United States)

Donald E. Hilt

1980-01-01

A taper-based system for estimating stem volumes is developed for Central States upland oaks. Inside bark diameters up the stem are predicted as a function of dbhib, total height, and powers and relative height. A Fortran IV computer program, OAKVOL, is used to predict cubic and board-foot volumes to any desired merchantable top dib. Volumes of...

Tank Waste Remediation System, Hanford Site, Richland, Washington. Final Environmental Impact Statement. Volume VI

International Nuclear Information System (INIS)

1996-08-01

The U.S. Department Of Energy and the Washington State Department of Ecology added Appendix L (Volume 6), Response to Public Comments, to the Tank Waste Remediation System (TWRS) Final Environmental Impact Statement (EIS) for the Hanford Site, Richland, Washington, to fully address and respond to public comments on the Draft EIS. In addition, DOE considered public comments, along with other factors such as programmatic need, short- and long-term impacts, technical feasibility, and cost, in arriving at DOE's preferred alternative. During the public comment period for the Draft EIS, more than 350 individuals, agencies, Tribal Nations, and organizations provided comments. This volume represents a broad spectrum of private citizens; businesses; local, State, and Federal officials; Tribal Nations; and public interest groups

The ratio of right ventricular volume to left ventricular volume reflects the impact of pulmonary regurgitation independently of the method of pulmonary regurgitation quantification

International Nuclear Information System (INIS)

Śpiewak, Mateusz; Małek, Łukasz A.; Petryka, Joanna; Mazurkiewicz, Łukasz; Miłosz, Barbara; Biernacka, Elżbieta K.; Kowalski, Mirosław; Hoffman, Piotr; Demkow, Marcin; Miśko, Jolanta; Rużyłło, Witold

2012-01-01

Background: Previous studies have advocated quantifying pulmonary regurgitation (PR) by using PR volume (PRV) instead of commonly used PR fraction (PRF). However, physicians are not familiar with the use of PRV in clinical practice. The ratio of right ventricle (RV) volume to left ventricle volume (RV/LV) may better reflect the impact of PR on the heart than RV end-diastolic volume (RVEDV) alone. We aimed to compare the impact of PRV and PRF on RV size expressed as either the RV/LV ratio or RVEDV (mL/m 2 ). Methods: Consecutive patients with repaired tetralogy of Fallot were included (n = 53). PRV, PRF and ventricular volumes were measured with the use of cardiac magnetic resonance. Results: RVEDV was more closely correlated with PRV when compared with PRF (r = 0.686, p 2.0 [area under the curve (AUC) PRV = 0.770 vs AUC PRF = 0.777, p = 0.86]. Conversely, with the use of the RVEDV-based criterion (>170 mL/m 2 ), PRV proved to be superior over PRF (AUC PRV = 0.770 vs AUC PRF = 0.656, p = 0.0028]. Conclusions: PRV and PRF have similar significance as measures of PR when the RV/LV ratio is used instead of RVEDV. The RV/LV ratio is a universal marker of RV dilatation independent of the method of PR quantification applied (PRF vs PRV)

Metabolic tumor volume measured by F 18 FDG PET/CT can further stratify the prognosis of patients with stage IV Non Small Cell Lung Cancer

Energy Technology Data Exchange (ETDEWEB)

Yoo, Su Woong; Kim, Ja Hae; Chong, Ar I; Kwon, Seong Young; Min, Jung Joon; Song, Ho Chun; Bom, Hee Seung [Chonnam National Univ. Hwasun Hospital, Gwangju (Korea, Republic of)

2012-12-15

This study aimed to further stratify prognostic factors in patients with stage IV non small cell lung cancer (NSCLC) by measuring their metabolic tumor volume (MTV) using F 18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). The subjects of this retrospective study were 57 patients with stage IV NSCLC. MTV, total lesion glycolysis (TLG), and maximum standardized uptake value (SUVmax) were measured on F 18 FDG PET/CT in both the primary lung lesion as well as metastatic lesions in torso. Optimal cutoff values of PET parameters were mea measured by receiver operating characteristic (ROC) curve anal analysis. Kaplan Meier survival (PET). The univariate and multivariate cox proportional hazards models were used to select the significant prognostic factors. Univariate analysis showed that both MTV and TLG of primary lung lesion (MTV lung and TLG lung) were significant factors for prediction of PFS ( <0.001 =0.038, respectively). Patients showing lower values of MTV lung and TLG lung than the cutoff values had significantly longer mean PFS than those with higher values. hazard ratios (95% confidence interval) of MTV lung and TLG lung measured by univariate analysis were 6.4 (2.5 16.3) and 2.4 (1.0 5.5), respectively. multivariate analysis revealed that MTV lung was the only significant factor for prediction of prognosis. Hazard ratio was 13,5 (1.6 111.1, =0,016). patients with stage IV NSCLC could be further stratified into subgroups of significantly better and worse prognosis by MTV of primary lung lesion.

Metabolic tumor volume measured by F 18 FDG PET/CT can further stratify the prognosis of patients with stage IV Non Small Cell Lung Cancer

International Nuclear Information System (INIS)

Yoo, Su Woong; Kim, Ja Hae; Chong, Ar I; Kwon, Seong Young; Min, Jung Joon; Song, Ho Chun; Bom, Hee Seung

2012-01-01

This study aimed to further stratify prognostic factors in patients with stage IV non small cell lung cancer (NSCLC) by measuring their metabolic tumor volume (MTV) using F 18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). The subjects of this retrospective study were 57 patients with stage IV NSCLC. MTV, total lesion glycolysis (TLG), and maximum standardized uptake value (SUVmax) were measured on F 18 FDG PET/CT in both the primary lung lesion as well as metastatic lesions in torso. Optimal cutoff values of PET parameters were mea measured by receiver operating characteristic (ROC) curve anal analysis. Kaplan Meier survival (PET). The univariate and multivariate cox proportional hazards models were used to select the significant prognostic factors. Univariate analysis showed that both MTV and TLG of primary lung lesion (MTV lung and TLG lung) were significant factors for prediction of PFS ( <0.001 =0.038, respectively). Patients showing lower values of MTV lung and TLG lung than the cutoff values had significantly longer mean PFS than those with higher values. hazard ratios (95% confidence interval) of MTV lung and TLG lung measured by univariate analysis were 6.4 (2.5 16.3) and 2.4 (1.0 5.5), respectively. multivariate analysis revealed that MTV lung was the only significant factor for prediction of prognosis. Hazard ratio was 13,5 (1.6 111.1, =0,016). patients with stage IV NSCLC could be further stratified into subgroups of significantly better and worse prognosis by MTV of primary lung lesion

Asset price and trade volume relation in artificial market impacted by value investors

Science.gov (United States)

Tangmongkollert, K.; Suwanna, S.

2016-05-01

The relationship between return and trade volume has been of great interests in a financial market. The appearance of asymmetry in the price-volume relation in the bull and bear market is still unsettled. We present a model of the value investor traders (VIs) in the double auction system, in which agents make trading decision based on the pseudo fundamental price modelled by sawtooth oscillations. We investigate the system by two different time series for the asset fundamental price: one corresponds to the fundamental price in a growing phase; and the other corresponds to that in a declining phase. The simulation results show that the trade volume is proportional to the difference between the market price and the fundamental price, and that there is asymmetry between the buying and selling phases. Furthermore, the selling phase has more significant impact of price on the trade volume than the buying phase.

Technical data summary: Uranium(IV) production using a large scale electrochemical cell

International Nuclear Information System (INIS)

Hsu, T.C.

1984-05-01

This Technical Data Summary outlines an electrochemical process to produce U(IV), in the form of uranous nitrate, from U(VI), as uranyl nitrate. U(IV) with hydrazine could then be used as an alternative plutonium reductant to substantially reduce the waste volume from the Purex solvent extraction process. This TDS is divided into three parts. The first part (Chapters I to IV) generally describes the electrochemical production of U(IV). The second part (Chapters V to VII) describes a pilot scale U(IV) production facility that was constructed and operated at an engineering semiworks area of SRP, referred to as TNX. The lst part (Chapter VIII) describes a preliminary design for a full-scale facility that would meet the projected need for U(IV) as a reductant in SRP's separations processes. The preliminary design was described in a Basic Data Summary for the U(IV) production facility, and a Venture Guidance Appraisal (VGA) was prepared from the Basic Data Summary. The VGA for the U(IV) process showed that because of the large capital investment required, this approach to waste reduction was not economically competitive with another alternative that required only modifying the ongoing Purex process at no additional capital cost. However, implementing he U(IV) process as part of an overall canyon renovation, presently scheduled for the 1990's, may be economically attractive. The purpose of this TDS is therefore to bring together the information and experience obtained thus far in the U(IV) program so that a useful body of information will be available to support any future development of this process

2004 Power marketing program final EIS - final environmental impact statement. Volume 2 - appendices

International Nuclear Information System (INIS)

1997-02-01

This volume contains appendices to the Final Environmental Impact Statement (FEIS) for the Power Marketing Program proposal of the Western Area Power Administration. The FEIS identified peaking power scheduling as the environmentally preferred alternative, and presented the analysis of alternatives and environmental impacts. Sixteen appendices to the FEIS are included in this document. The appendices are: Statutory and Legal Framework; Sierra Nevada Region Customer Groups and Economic Regions; Renewable Technology Cost Information Matrix; Hydrological Assumptions; Recreation Resources; Archaeological and Historical Resources; Incremental Power Resources; Air Quality Regulatory Structure; Energy Generation; Stage Contents Relationships for Regulating Reservoirs; Power Costs; Socioeconomic Impacts; Projected Air Resource Impacts; Land use, Water Quality, and Solid Waste Impact Factors; Draft Environmental Impact Statement Comments and Responses, and Contractor Disclosure Statements. 21 figs., 24 tabs

Asteroids IV

Science.gov (United States)

Michel, Patrick; DeMeo, Francesca E.; Bottke, William F.

. Asteroids, like planets, are driven by a great variety of both dynamical and physical mechanisms. In fact, images sent back by space missions show a collection of small worlds whose characteristics seem designed to overthrow our preconceived notions. Given their wide range of sizes and surface compositions, it is clear that many formed in very different places and at different times within the solar nebula. These characteristics make them an exciting challenge for researchers who crave complex problems. The return of samples from these bodies may ultimately be needed to provide us with solutions. In the book Asteroids IV, the editors and authors have taken major strides in the long journey toward a much deeper understanding of our fascinating planetary ancestors. This book reviews major advances in 43 chapters that have been written and reviewed by a team of more than 200 international authorities in asteroids. It is aimed to be as comprehensive as possible while also remaining accessible to students and researchers who are interested in learning about these small but nonetheless important worlds. We hope this volume will serve as a leading reference on the topic of asteroids for the decade to come. We are deeply indebted to the many authors and referees for their tremendous efforts in helping us create Asteroids IV. We also thank the members of the Asteroids IV scientific organizing committee for helping us shape the structure and content of the book. The conference associated with the book, "Asteroids Comets Meteors 2014" held June 30-July 4, 2014, in Helsinki, Finland, did an outstanding job of demonstrating how much progress we have made in the field over the last decade. We are extremely grateful to our host Karri Muinonnen and his team. The editors are also grateful to the Asteroids IV production staff, namely Renée Dotson and her colleagues at the Lunar and Planetary Institute, for their efforts, their invaluable assistance, and their enthusiasm; they made life as

Test Review: Advanced Clinical Solutions for WAIS-IV and WMS-IV

Science.gov (United States)

Chu, Yiting; Lai, Mark H. C.; Xu, Yining; Zhou, Yuanyuan

2012-01-01

The authors review the "Advanced Clinical Solutions for WAIS-IV and WMS-IV". The "Advanced Clinical Solutions (ACS) for the Wechsler Adult Intelligence Scale-Fourth Edition" (WAIS-IV; Wechsler, 2008) and the "Wechsler Memory Scale-Fourth Edition" (WMS-IV; Wechsler, 2009) was published by Pearson in 2009. It is a…

Direct complexonometric determination of thorium (IV), uranium (IV), neptunium (IV), plutonium (IV) by titration of diethylenetriaminepentaacetic acid with xylenol orange as indicator

International Nuclear Information System (INIS)

Rykov, A.G.; Piskunov, E.M.; Timofeev, G.A.

1975-01-01

The purpose of the present work was to develop a method of determining Th(IV), U(IV), Np(N) and Pu(IV) in acid solutions by titration with diethylenetriamine pentacetic acid, the indicator being xylenol orange. It has been established that Th, U, Np and Pu can be determined to within 0.5-1.5%. Th and U in quantities of tens of milligrams can be determined with greater accuracy, attaining hundredths of one per cent. During titration the determination is not hindered by singly- and doubly-charged metal ions, trivalent lanthanides and actinides, except plutonium. The proposed method can be used to determine U(IV) in the presence of considerable quantities of U(VI) and Np(IV) in the presence of Np(V). Total concentrations of uranium or neptunium are determined by reducing uranium (VI) or neptunium (V) by a standard method (for example, using metallic lead, cadmium or zinc amalgam) to the tetravalent state and applying the method described in the paper. (E.P.)

Impact of altering DSM-IV criteria for anorexia and bulimia nervosa on the base rates of eating disorder diagnoses.

Science.gov (United States)

Thaw, J M; Williamson, D A; Martin, C K

2001-09-01

The diagnostic criteria used to define eating disorders have been the focus of debate for many years. The primary aim of this study was to evaluate the impact of altering DSM-IV diagnostic criteria upon the base rates of anorexia nervosa (AN), bulimia nervosa (BN) and eating disorder not otherwise specified (EDNOS). Five controversial criteria were systematically modified and the impact of these changes on base rates of full-syndrome and partial-syndrome eating disorders was assessed in 193 patients referred to two specialty eating disorder clinics. Modification of a single criterion resulted in relatively small changes in base rates of AN and BN, whereas modification of the two severity criteria led to more substantial changes. These findings have significant implications for future modifications of the DSM classification.

The irradiation lung volume in tangential fields for the treatment of a breast

International Nuclear Information System (INIS)

Oh, Y. T.; Kim, J. R.; Kang, H. J.; Sohn, J. H.; Kang, S. H.; Chun, M. S.

1997-01-01

Radiation pneumonitis is one of the complications caused by radiation therapy that includes a portion of the lung tissue. The severity of radiation induced pulmonary dysfunction depends on the irradiated lung volume, total dose, dose rate and underlying pulmonary function. The lung volume was measured for 25 patients with breast cancer irradiated with tangential field from Jan. 1995 to Aug. 1996. Parameters that can predict the irradiated lung volume included; (1) the perpendicular distance from the posterior tangential edge to the posterior part of the anterior chest wall at the center of the field (CLD); (2) the maximum perpendicular distance from the posterior tangential field edge to the posterior part of the anterior chest wall (MLD); (3) the greatest perpendicular distance from the posterior tangential edge to the posterior part of anterior chest wall on CT image at the center of the longitudinal field (GPD); (4) the length of the longitudinal field (L). The irradiated lung volume(RV), the entire both lung volume(EV) and the ipsilateral lung volume(IV) were measured using dose volume histogram. The RV is 61-279cc, the RV/EV is 2.9-13.0% and the RV/EN is 4.9-29.6%. The CLD, the MLD and the GPD are 1.9-3.3cm and 1.4-3.1cm respectively. The significant relations between the irradiated lung volume such as RV, RV/EV, RV/IV and parameters such as CLD, MLD, GPD, L, CLD x L, MLD x L and GPD x L are not found with little variances in parameters. The RV/IV of the left breast irradiation is significances. The significant relationship between the irradiated lung volume and predictors is not found with little variation on parameters. The irradiated lung volume in the tangential field is less than 10% of entire lung volume when CLD is less than 3cm. The RV/IV of the left tangential field is larger than that of the right but there was no significant differences in RV/EVs. Symptomatic radiation pneumonitis has not occurred during minimum 6 months follow up. (author)

Impacts of Outer Continental Shelf (OCS) development on recreation and tourism. Volume 5. Program logic manual

Energy Technology Data Exchange (ETDEWEB)

1987-04-01

The final report for the project is presented in five volumes. This volume is the Programmer's Manual. It covers: a system overview, attractiveness component of gravity model, trip-distribution component of gravity model, economic-effects model, and the consumer-surplus model. The project sought to determine the impact of Outer Continental Shelf development on recreation and tourism.

Impact of robotic technique and surgical volume on the cost of radical prostatectomy.

Science.gov (United States)

Hyams, Elias S; Mullins, Jeffrey K; Pierorazio, Phillip M; Partin, Alan W; Allaf, Mohamad E; Matlaga, Brian R

2013-03-01

Our present understanding of the effect of robotic surgery and surgical volume on the cost of radical prostatectomy (RP) is limited. Given the increasing pressures placed on healthcare resource utilization, such determinations of healthcare value are becoming increasingly important. Therefore, we performed a study to define the effect of robotic technology and surgical volume on the cost of RP. The state of Maryland mandates that all acute-care hospitals report encounter-level and hospital discharge data to the Health Service Cost Review Commission (HSCRC). The HSCRC was queried for men undergoing RP between 2008 and 2011 (the period during which robot-assisted laparoscopic radical prostatectomy [RALRP] was coded separately). High-volume hospitals were defined as >60 cases per year, and high-volume surgeons were defined as >40 cases per year. Multivariate regression analysis was performed to evaluate whether robotic technique and high surgical volume impacted the cost of RP. There were 1499 patients who underwent RALRP and 2565 who underwent radical retropubic prostatectomy (RRP) during the study period. The total cost for RALRP was higher than for RRP ($14,000 vs 10,100; Probotic surgery has come to dominate the healthcare marketplace, strategies to increase the role of high-volume providers may be needed to improve the cost-effectiveness of prostate cancer surgical therapy.

Liquid Metal Fast Breeder Reactor program. Volume IV. Environmental statement

International Nuclear Information System (INIS)

1974-12-01

A broad overview is presented of the many implications of LMFBR program implementation, up to and encompassing a fully developed LMFBR power plant economy, including the secondary impacts, the unavoidable adverse environmental impacts, cumulative environmental impacts, and cost-benefit analyses, and alternative energy strategies. Under the heading of secondary impacts, the national implications of the availability of electricity from LMFBRs, and the specific economic impacts of the LMFBR program are examined. The currently feasible alternatives and potential future alternatives for mitigating adverse environmental impacts of the LMFBR fuel cycle are described. The problems of safeguarding special nuclear material from potential diversion to unauthorized purposes are analyzed. The cumulative environmental effects of LMFBR operation to the Year 2020, the decommissioning of LMFBRs and fuel cycle facilities upon the completion of their useful life, the irreversible and irretrievable commitments of resources that will accompany implementation of an LMFBR economy, and an analysis of the costs and benefits of implementing the LMFBR Program are included. (U.S.)

Lava flooding of ancient planetary crusts: geometry, thickness, and volumes of flooded lunar impact basins

International Nuclear Information System (INIS)

Head, J.W.

1982-01-01

Estimates of lava volumes on planetary surfaces provide important data on the lava flooding history and thermal evolution of a planet. Lack of information concerning the configuration of the topography prior to volcanic flooding requires the use of a variety of techniques to estimate lava thicknesses and volumes. A technique is described and developed which provides volume estimates by artificially flooding unflooded lunar topography characteristic of certain geological environments, and tracking the area covered, lava thicknesses, and lava volumes. Comparisons of map patterns of incompletely buried topography in these artificially flooded areas are then made to lava-flooded topography on the Moon in order to estimate the actual lava volumes. This technique is applied to two areas related to lunar impact basins; the relatively unflooded Orientale basin, and the Archimedes-Apennine Bench region of the Imbrium basin. (Auth.)

Dipeptidyl-peptidase IV (DPP-IV) inhibitor delays tolerance to anxiolytic effect of ethanol and withdrawal-induced anxiety in rats.

Science.gov (United States)

Sharma, Ajaykumar N; Pise, Ashish; Sharma, Jay N; Shukla, Praveen

2015-06-01

Dipeptidyl-peptidase IV (DPP-IV) is an enzyme responsible for the metabolism of endogenous gut-derived hormone, glucagon-like peptide-1 (GLP-1). DPP-IV is known for its role in energy homeostasis and pharmacological blockade of this enzyme is a recently approved clinical strategy for the management of type II diabetes. Accumulating evidences suggest that enzyme DPP-IV can affect spectrum of central nervous system (CNS) functions. However, little is known about the role of this enzyme in ethanol-mediated neurobehavioral complications. The objective of the present study was to examine the impact of DPP-IV inhibitor, sitagliptin on the development of tolerance to anxiolytic effect of ethanol and anxiety associated with ethanol withdrawal in rats. A dose-response study revealed that sitaglitpin (20 mg/kg, p.o.) per se exhibit anxiolytic effect in the elevated plus maze (EPM) test in rats. Tolerance to anxiolytic effect of ethanol (2 g/kg, i.p.; 8 % w/v) was observed from 7(th) day of ethanol-diet (6 % v/v) consumption. In contrast, tolerance to anxiolytic effect of ethanol was delayed in rats that were treated daily with sitagliptin (20 mg/kg, p.o.) as tolerance was observed from 13(th)day since commencement of ethanol-diet consumption. Discontinuation of rats from ethanol-diet after 15-days of ethanol consumption resulted in withdrawal anxiety between 8 h and 12 h post-abstinence. However, rats on 15-day ethanol-diet with concomitant sitagliptin (20 mg/kg, p.o.) treatment exhibited delay in appearance (24 h post-withdrawal) of withdrawal anxiety. In summary, DPP-IV inhibitors may prove as an attractive research strategy against ethanol tolerance and dependence.

Interobserver variations of target volume delineation and its impact on irradiated volume in accelerated partial breast irradiation with intraoperative interstitial breast implant

Directory of Open Access Journals (Sweden)

Ritu Raj Upreti

2017-02-01

Full Text Available Purpose: To investigate the interobserver variations in delineation of lumpectomy cavity (LC and clinical target volume (CTV, and its impact on irradiated volume in accelerated partial breast irradiation using intraoperative multicatheter brachytherapy. Material and methods : Delineation of LC and CTV was done by five radiation oncologists on planning computed tomography (CT scans of 20 patients with intraoperative interstitial breast implant. Cavity visualization index (CVI, four-point index ranging from (0 = poor to (3 = excellent was created and assigned by observers for each patient. In total, 200 contours for all observers and 100 treatment plans were evaluated. Spatial concordance (conformity index, CI common , and CIgen, average shift in the center of mass (COM, and ratio of maximum and minimum volumes (V max /V min of LC and CTV were quantified among all observers and statistically analyzed. Variation in active dwell positions (0.5 cm step for each catheter, total reference air kerma (TRAK, volume enclosed by prescription isodose (V100% among observers and its spatial concordance were analyzed. Results : The mean ± SD CI common of LC and CTV was 0.54 ± 0.09, and 0.58 ± 0.08, respectively. Conformity index tends to increase, shift in COM and V max /V min decrease significantly (p < 0.05, as CVI increased. Out of total 309 catheters, 29.8% catheters had no change, 29.8% and 17.5% catheters had variations of 1 and 2 dwell positions (0.5 cm and 1 cm, respectively. 9.3% catheters shown variations ≥ 10 dwell positions (5 cm. The mean ± SD CI common of V100% was 0.75 ± 0.11. The mean observed V max /V min of prescription isodose and TRAK was 1.18 (range, 1.03 to 1.56 and 1.11 (range, 1.03 to 1.35, respectively. Conclusions : Interobserver variability in delineation of target volume was found to be significantly related to CVI. Smaller variability was observed with excellent visualization of LC. Interobserver variations showed dosimetric

Congenital bilateral neuroblastoma (stage IV-S): case report

International Nuclear Information System (INIS)

Lee, Jeong Hee; Lee, Hee Jung; Woo, Seong Ku; Lee, Sang Rak; Kim, Heung Sik

2002-01-01

Congenital neonatal neuroblastoma is not uncommon but bilateral adrenal neuroblastoma is rare, accounting for about ten percent of neuroblastomas in children. We report the US the MR findings of a stage IV-S congenital bilateral neuroblastoma occurring in a one-day-old neonate

Angiotensin IV and the human esophageal mucosa: An exploratory study in healthy subjects and gastroesophageal reflux disease patients.

Science.gov (United States)

Björkman, Eleonora; Edebo, Anders; Fändriks, Lars; Casselbrant, Anna

2015-09-01

The human esophageal mucosa expresses various components of the renin-angiotensin system (RAS), e.g. the main effector peptide angiotensin II (AngII). The aim of this study was to investigate the esophageal presence of angiotensin III (AngIII) and angiotensin IV (AngIV) forming enzymes and the AngIV receptor (AT4R). The aim was also to study the actions of AngIV and to look for aberrations in patients with gastroesophageal reflux disease (GERD). Esophageal biopsies were collected from healthy volunteers (n: 19) and individuals with erosive reflux disease (n: 14). Gene transcripts and protein expression of aminopeptidase A, -B and -M, and the AT4R were investigated by reverse transcriptase polymerase chain reaction (rt-PCR), western blot (WB) and immunohistochemistry (IHC). The functional impact of AngIV was examined in an Ussing chamber. Aminopeptidase A, -B and -M and the AT4R were expressed in the esophageal epithelium. The AT4R was less prominent in certain areas in the mucosa of reflux patients. AngIV influenced the esophageal epithelial ion transport. The impact was lower in patients with GERD. The AT4R and formation enzymes of AngIII and AngIV are present in the human esophageal epithelium. Moreover, the present results suggest that AngIV exert regulatory impact on the epithelium and that RAS is involved in mucosal aberrations associated with GERD. © The Author(s) 2014.

Impact of Medical Therapy on Atheroma Volume Measured by Different Cardiovascular Imaging Modalities

Directory of Open Access Journals (Sweden)

Mohamad C. N. Sinno

2010-01-01

Full Text Available Atherosclerosis is a systemic disease that affects most vascular beds. The gold standard of atherosclerosis imaging has been invasive intravascular ultrasound (IVUS. Newer noninvasive imaging modalities like B-mode ultrasound, cardiac computed tomography (CT, positron emission tomography (PET, and magnetic resonance imaging (MRI have been used to assess these vascular territories with high accuracy and reproducibility. These imaging modalities have lately been used for the assessment of the atherosclerotic plaque and the response of its volume to several medical therapies used in the treatment of patients with cardiovascular disease. To study the impact of these medications on atheroma volume progression or regression, imaging modalities have been used on a serial basis providing a unique opportunity to monitor the effect these antiatherosclerotic strategies exert on plaque burden. As a result, studies incorporating serial IVUS imaging, quantitative coronary angiography (QCA, B-mode ultrasound, electron beam computed tomography (EBCT, and dynamic contrast-enhanced magnetic resonance imaging have all been used to evaluate the impact of therapeutic strategies that modify cholesterol and blood pressure on the progression/regression of atherosclerotic plaque. In this review, we intend to summarize the impact of different therapies aimed at halting the progression or even result in regression of atherosclerotic cardiovascular disease evaluated by different imaging modalities.

Immunohistochmical Study of Glomerular Mesengial Collagen IV Expression in Diabetic Balb/c Mice

Directory of Open Access Journals (Sweden)

M. Jalali

2006-04-01

Full Text Available Introduction & Objective: Extra-cellular matrix and basement membrane play important roles in many developmental phenamenon during development and after birth. Among the components of the basement membrane, collagen fibers specially type IV, are the most important part of this area. As kidney is one of the target organs in diabetes mellitus and diabetic nephropathy is a major cause of end stage-renal disease and result an increase in morbidity and mortality of effected individuals, therefore early diagnosis leads to better treatment. The aim of this investigation was to study the primary diagnostic parameters by special regards to collagen IV fibers.Materials & Methods: In this study, 24 male balb/c mice were divided into experimental and control groups. In experimental group, the beta cells of Langerhance were chemically destroyed by an injection of 160 mg/kg alloxan and subdivided in experimental groups 1 and 2. Controls were kept untreated. Experimental group 1and 2 were sacrified 8 and 16 weeks after treatment with alloxan respectively. The same procedure was performed for control group. Immunohistochmical studies were carried out using monocolonal antibody against collagen type IV in Glomeruli. In addition, using morphometrical and stereological methods the volume of the glumerles was compared in all groups.Results: Our finding showed that in experimental groups with special regards in 16 weeks diabetic mice, the rate of collagen type IV in basement membrane around the parietal layer of Bowman capsule, mesangial cells and endothelium of capillary in glomerules increased significantly compared to controls and experimental group 1 (p<0.05, while there was not a significant difference among experimental group 2 and controls. Our data also revealed that the number of mesangial cells as well as glomerular volume increased significantly in experimental 2 (4.635±0.289×106µm3 compared to experimental 1 (3.504±0.189×106µm3 and controls (3.422�

Survival Impact of Adjuvant Radiation Therapy in Masaoka Stage II to IV Thymomas: A Systematic Review and Meta-analysis

International Nuclear Information System (INIS)

Lim, Yu Jin; Kim, Eunji; Kim, Hak Jae; Wu, Hong-Gyun; Yan, Jinchun; Liu, Qin; Patel, Shilpen

2016-01-01

Purpose: To evaluate the survival impact of postoperative radiation therapy (PORT) in stage II to IV thymomas, using systematic review and meta-analysis. Methods and Materials: A database search was conducted with EMBASE, PubMed, Web of Science, Cochrane Library, and Ovid from inception to August 2015. Thymic carcinomas were excluded, and studies comparing overall survival (OS) with and without PORT in thymomas were included. The hazard ratios (HRs) of OS were extracted, and a random-effects model was used in the pooled analysis. Results: Seven retrospective series with a total of 1724 patients were included and analyzed. Almost all of the patients underwent macroscopically complete resection, and thymoma histology was confirmed by the World Health Organization criteria. In the overall analysis of stage II to IV thymomas, OS was not altered with the receipt of PORT (HR 0.79, 95% confidence interval [CI] 0.58-1.08). Although PORT was not associated with survival difference in Masaoka stage II disease (HR 1.45, 95% CI 0.83-2.55), improved OS was observed with the addition of PORT in the discrete pooled analysis of stage III to IV (HR 0.63, 95% CI 0.40-0.99). Significant heterogeneity and publication bias were not found in the analyses. Conclusions: From the present meta-analysis of sole primary thymomas, we suggest the potential OS benefit of PORT in locally advanced tumors with macroscopically complete resection, but not in stage II disease. Further investigations with sufficient survival data are needed to establish detailed treatment indications.

Survival Impact of Adjuvant Radiation Therapy in Masaoka Stage II to IV Thymomas: A Systematic Review and Meta-analysis

Energy Technology Data Exchange (ETDEWEB)

Lim, Yu Jin; Kim, Eunji [Department of Radiation Oncology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Kim, Hak Jae, E-mail: khjae@snu.ac.kr [Department of Radiation Oncology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Wu, Hong-Gyun [Department of Radiation Oncology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Cancer Research Institute, Seoul National University College of Medicine, Seoul (Korea, Republic of); Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul (Korea, Republic of); Yan, Jinchun [Department of Radiation Oncology, Dalian Medical University, Liaoning (China); Department of Radiation Oncology, Fudan University Cancer Hospital, Shanghai (China); Liu, Qin [The Wistar Institute, Philadelphia, Pennsylvania (United States); Patel, Shilpen [Department of Radiation Oncology, University of Washington Medical Center, Seattle, Washington (United States)

2016-04-01

Purpose: To evaluate the survival impact of postoperative radiation therapy (PORT) in stage II to IV thymomas, using systematic review and meta-analysis. Methods and Materials: A database search was conducted with EMBASE, PubMed, Web of Science, Cochrane Library, and Ovid from inception to August 2015. Thymic carcinomas were excluded, and studies comparing overall survival (OS) with and without PORT in thymomas were included. The hazard ratios (HRs) of OS were extracted, and a random-effects model was used in the pooled analysis. Results: Seven retrospective series with a total of 1724 patients were included and analyzed. Almost all of the patients underwent macroscopically complete resection, and thymoma histology was confirmed by the World Health Organization criteria. In the overall analysis of stage II to IV thymomas, OS was not altered with the receipt of PORT (HR 0.79, 95% confidence interval [CI] 0.58-1.08). Although PORT was not associated with survival difference in Masaoka stage II disease (HR 1.45, 95% CI 0.83-2.55), improved OS was observed with the addition of PORT in the discrete pooled analysis of stage III to IV (HR 0.63, 95% CI 0.40-0.99). Significant heterogeneity and publication bias were not found in the analyses. Conclusions: From the present meta-analysis of sole primary thymomas, we suggest the potential OS benefit of PORT in locally advanced tumors with macroscopically complete resection, but not in stage II disease. Further investigations with sufficient survival data are needed to establish detailed treatment indications.

INFLUENCE OF NATURAL AND SYNTHETIC ORGANIC LIGANDS ON THE STABILITY AND MOBILITY OF REDUCED TC(IV)

Energy Technology Data Exchange (ETDEWEB)

Nathalie A. Wall; Baohua Gu

2012-12-20

The primary objectives were (1) to quantify the interactions of organic ligands with Tc(IV) through the generation of thermodynamic (complexation) and kinetic parameters needed to assess and predict the mobility of reduced Tc(IV) at DOE contaminated sites; and (2) to determine the impact of organic ligands on the mobility and fate of reduced Tc(IV) under field geochemical conditions.

Impact of systematic errors on DVH parameters of different OAR and target volumes in Intracavitary Brachytherapy (ICBT)

International Nuclear Information System (INIS)

Mourya, Ankur; Singh, Gaganpreet; Kumar, Vivek; Oinam, Arun S.

2016-01-01

Aim of this study is to analyze the impact of systematic errors on DVH parameters of different OAR and Target volumes in intracavitary brachytherapy (ICBT). To quantify the changes in dose-volume histogram parameters due to systematic errors in applicator reconstruction of brachytherapy planning, known errors in catheter reconstructions have to be introduced in applicator coordinate system

Ionizing radiation risk assessment, BEIR IV

International Nuclear Information System (INIS)

1991-10-01

This report of the Subpanel discusses the potential impact on Federal agencies and indicates individual risk factors that could be used by them in risk assessment. The approach used in this CIRRPC report was to consider the risk factors presented in BEIR IV for each radionuclide (or group radioelements) and to make some judgments regarding their validity and/or the uncertainties involved. The coverage of Radon-222 and its progeny dominated the BEIR IV report and this Subpanel felt is was proper to devote more attention to this radionuclide family. This risk factor presented in BEIR IV for radon is 350 cancer deaths per million person-working level months (WLM) of exposure for a lifetime. There is a range of opinions on the conversion from WLM to absorbed dose. As discussed in the text, the use of the WLM concept makes it difficult or infeasible to compare the risk factor for radon with that of other radionuclides which are based on organ dose. This report also includes a discussion of certain fundamental scientific and operational issues that may have decisive effect upon risk factor selection. These adjunct items are dealt with under separate headings and include discussions of threshold dose considerations, extrapolation to low doses, and age at exposure

Initial Northwest Power Act Power Sales Contracts : Final Environmental Impact Statement. Volume 1, Environmental Analysis.

Energy Technology Data Exchange (ETDEWEB)

United States. Bonneville Power Administration.

1992-01-01

This is volume 1 of the final environmental impact statement of the Bonneville Power Administration Information is included on the following: Purpose of and need for action; alternatives including the proposed action; affected environment; and environmental consequences.

Draft Hanford Remedial Action Environmental Impact Statement and Comprehensive Land Use Plan. Volume 3 of 4

International Nuclear Information System (INIS)

1996-08-01

This volume of the Environmental Impact Statement contains ten appendices. These appendices contain the following: the ecological risk assessment methodology and calculations; the strategy for remediation of contaminated ground water; a description of the reference barrier and potential quarry sites that could be used to supply materials for barriers; the methodology for estimating socio-economic impacts; the methodology for evaluation of air quality impacts; an assessment of costs and physical impacts; the calculation of estimated industrial health and safety occupational losses; a floodplains and wetlands impact assessment; information about Hanford waste sites, and US EPA guidance on using land-use decisions in remediation

Oxochloroalkoxide of the Cerium (IV and Titanium (IV as oxides precursor

Directory of Open Access Journals (Sweden)

Machado Luiz Carlos

2002-01-01

Full Text Available The Cerium (IV and Titanium (IV oxides mixture (CeO2-3TiO2 was prepared by thermal treatment of the oxochloroisopropoxide of Cerium (IV and Titanium (IV. The chemical route utilizing the Cerium (III chloride alcoholic complex and Titanium (IV isopropoxide is presented. The compound Ce5Ti15Cl16O30 (iOPr4(OH-Et15 was characterized by elemental analysis, FTIR and TG/DTG. The X-ray diffraction patterns of the oxides resulting from the thermal decomposition of the precursor at 1000 degreesC for 36 h indicated the formation of cubic cerianite (a = 5.417Å and tetragonal rutile (a = 4.592Å and (c = 2.962 Å, with apparent crystallite sizes around 38 and 55nm, respectively.

Impact of Formulas, Language and Instruction on Student Performance on Cost-Volume-Profit Problems

Science.gov (United States)

Johnson, Benny G.; Sargent, Carol Springer

2014-01-01

This study investigated how three factors impacted performance on cost-volume-profit homework problems: language, formula use, and instruction. Students enrolled in Introduction to Financial Accounting (the first principles of accounting course) and Managerial Accounting (the second principles of accounting course) from eight different US colleges…

Waste Isolation Pilot Plant disposal phase final supplemental environmental impact statement. Volume 2: Appendices

International Nuclear Information System (INIS)

1997-09-01

The purpose of the Waste Isolation Pilot Plant Disposal Final Supplemental Environmental Impact Statement (SEIS-II) is to provide information on environmental impacts regarding the Department of Energy's (DOE) proposed disposal operations at WIPP. The Proposed Action describes the treatment and disposal of the Basic inventory of TRU waste over a 35-year period. The Action Alternatives proposed the treatment of the Basic Inventory and an Additional Inventory as well as the transportation of the treated waste to WIPP for disposal over a 150- to 190-year period. The three Action Alternatives include the treatment of TRU waste at consolidation sites to meet WIPP planning-basic Waste Acceptance Criteria, the thermal treatment of TRU waste to meet Land Disposal Restrictions, and the treatment of TRU waste by a shred and grout process. SEIS-II evaluates environmental impacts resulting from the various treatment options; the transportation of TRU waste to WIPP using truck, a combination of truck and regular rail service, and a combination of truck and dedicated rail service; and the disposal of this waste in the repository. Evaluated impacts include those to the general environment and to human health. Additional issues associated with the implementation of the alternatives are discussed to provide further understanding of the decisions to be reached and to provide the opportunity for public input on improving DOE's Environmental Management Program. This volume contains the following appendices: Waste inventory; Summary of the waste management programmatic environmental impact statement and its use in determining human health impacts at treatment sites; Air quality; Life-cycle costs and economic impacts; Transportation; Human health; Facility accidents; Long-term consequence analysis for proposed action and action alternatives; Long-term consequence analysis for no action alternative 2; and Updated estimates of the DOE's transuranic waste volumes

Impacts of Outer Continental Shelf (OCS) development on recreation and tourism. Volume 4. User's manual

Energy Technology Data Exchange (ETDEWEB)

1987-04-01

The final report for the project is presented in five volumes. The project sought to determine the impact of Outer Continental Shelf development on recreation and tourism in California. This volume is the User's Guide. It includes the following topics: Introduction and Summary Guide; Input Data Files; Gravity Model Programs; Economic Effects Model Programs; Consumer Surplus Model Programs; References; and Appendices.

OLI/ESP Modeling Of The Semi-Integrated Pilot Plant For Estimate Of Campaigns I-IV Simulant Volumes

International Nuclear Information System (INIS)

CARL, BARNES

2004-01-01

Four SIPP campaigns have been planned to investigate the effect of recycle streams on the RPP-WTP pretreatment process such as the filter flux rate and other areas of interest. This document describes OLI/ESP modeling work done in support of the planning and operation of the SIPP. An existing OLI/ESP steady-state model was expanded to represent the pretreatment system through to the TLP evaporator for the LAW train and the washed sludge for the HLW train. The model was used to investigate alternative operating scenarios, determine the optimum volumetric waste feed ratio of AP-101 to AY-102, and, for each campaign, estimate the simulant and input recycle volumes corresponding to the target glass production rates of 6MT/day HLW glass and 80MT/day LAW glass and scaled to the target of 140L of Campaign I washed sludge. It was designed to quickly achieve steady state and simulation results indicate this was accomplished by Campaign IV. The alternative operating scenarios modeled differed only in the point at which the AP-101 and AY-102 waste feed streams were introduced to the process. The results showed no difference in the production rate between the scenarios. Therefore, for these specific waste feeds the process should be operated to maximize the energy efficiency and minimize scaling in the evaporator by feeding the AY-102 waste feed to the ultra-filtration feed prep tank, bypassing the waste feed evaporator

Extending the Use of Highly Porous and Functionalized MOFs to Th(IV) Capture.

Science.gov (United States)

Zhang, Nan; Yuan, Li-Yong; Guo, Wen-Lu; Luo, Shi-Zhong; Chai, Zhi-Fang; Shi, Wei-Qun

2017-08-02

Thorium separation has recently become a hot topic because of the potential application of thorium as a future nuclear fuel, while metal-organic framework (MOF) materials have received much attention in the separation field due to their unique properties. Herein, a highly porous and stable MOF, UiO-66, and its carboxyl derivatives (UiO-66-COOH and UiO-66-(COOH) 2 ) were synthesized and explored for the first time for Th(IV) capture from a weak acidic solution. Although the introduction of carboxyl groups into UiO-66 leads to an obvious decrease in the surface area and pore volume, the adsorbability toward Th(IV) is greatly enhanced. At pH = 3.0, the saturated sorption capacity for Th(IV) into UiO-66-(COOH) 2 reached 350 mg/g, representing one of the largest values for Th(IV) capture by solid extraction. Moreover, the functionalized MOFs show fast sorption kinetics and desirable selectivity toward Th(IV) over a range of competing metal ions. A possible mechanism for the selective recognition of Th(IV) by these MOFs was explored on the basis of extended X-ray absorption fine structure and Fourier transform infrared analysis. It is concluded that UiO-66-COOH and UiO-66-(COOH) 2 sorb Th(IV) through the coordination of carboxyl anions in the pores of the MOFs, whereas in the case of UiO-66, both the precipitation and the exchange with the organic solvent contribute to the Th(IV) uptake. This study contributes to the assessment of the feasibility of MOFs applied in actinides separation and better understanding of actinides sorption behavior in this kind of hybrid porous solid materials.

The Impact of Hospital Closures and Hospital and Population Characteristics on Increasing Emergency Department Volume: A Geographic Analysis.

Science.gov (United States)

Lee, David C; Carr, Brendan G; Smith, Tony E; Tran, Van C; Polsky, Daniel; Branas, Charles C

2015-12-01

Emergency visits are rising nationally, whereas the number of emergency departments is shrinking. However, volume has not increased uniformly at all emergency departments. It is unclear what factors account for this variability in emergency volume growth rates. The objective of this study was to test the association of hospital and population characteristics and the effect of hospital closures with increases in emergency department volume. The study team analyzed emergency department volume at New York State hospitals from 2004 to 2010 using data from cost reports and administrative databases. Multivariate regression was used to evaluate characteristics associated with emergency volume growth. Spatial analytics and distances between hospitals were used in calculating the predicted impact of hospital closures on emergency department use. Among the 192 New York hospitals open from 2004 to 2010, the mean annual increase in emergency department visits was 2.7%, but the range was wide (-5.5% to 11.3%). Emergency volume increased nearly twice as fast at tertiary referral centers (4.8%) and nonurban hospitals (3.7% versus urban at 2.1%) after adjusting for other characteristics. The effect of hospital closures also strongly predicted variation in growth. Emergency volume is increasing faster at specific hospitals: tertiary referral centers, nonurban hospitals, and those near hospital closures. This study provides an understanding of how emergency volume varies among hospitals and predicts the effect of hospital closures in a statewide region. Understanding the impact of these factors on emergency department use is essential to ensure that these populations have access to critical emergency services.

A reflectance flow-through thionine sol-gel sensor for the determination of Se(IV).

Science.gov (United States)

Carvalhido, Joana A E; Almeida, Agostinho A; Araújo, Alberto N; Montenegro, Maria C B S M

2010-01-01

In this work, a reversible sensor to assess the total Se(IV) content in samples is described. Pre-activated glass slides were spin-coated with 100 microL of a 20-h aged sol-gel mixture of 1 mL of tetramethoxysilane, 305 microL of 50 mmol L(-1) HCl and 2.0 mg of thionine. The flow-cell consisted of one of those slides as a window, and was filled with beads of a polystyrene anionic exchange resin to retain Se(IV) in the form of selenite ions. A reflectance transduction scheme at a wavelength of 596 nm was adopted. The cell was coupled to a multicommutation flow system where a programmed volume of a sample solution and 373 microL of 0.4 mmol L(-1) iodide in a 1.6 mol L(-1) HCl solution were sequentially inserted into the cell. The iodine produced from the reaction of retained Se(IV) with iodide bleached the blue color of thionine. Considering a sample volume of 2.30 mL, with which the preconcentration step was minimized, a linear dynamic working range between 1.5 to 20 microg mL(-1) and a detection limit of 0.29 microg mL(-1) were obtained. The sensor enabled us to perform approximately 200 assays, and provided results similar to those of electrothermal atomic absorption spectrometry.

Urinary type IV collagen is related to left ventricular diastolic function and brain natriuretic peptide in hypertensive patients with prediabetes.

Science.gov (United States)

Iida, Masato; Yamamoto, Mitsuru; Ishiguro, Yuko S; Yamazaki, Masatoshi; Ueda, Norihiro; Honjo, Haruo; Kamiya, Kaichirou

2014-01-01

Urinary type IV collagen is an early biomarker of diabetic nephropathy. Concomitant prediabetes (the early stage of diabetes) was associated with left ventricular (LV) diastolic dysfunction and increased brain natriuretic peptide (BNP) in hypertensive patients. We hypothesized that urinary type IV collagen may be related to these cardiac dysfunctions. We studied hypertensive patients with early prediabetes (HbA1c 110, n=18), those with prediabetes (HbA1c 5.7-6.4, n=98), and those with diabetes (HbA1c>6.5 or on diabetes medications, n=92). The participants underwent echocardiography to assess left atrial volume/body surface area (BSA) and the ratio of early mitral flow velocity to mitral annular velocity (E/e'). Left ventricular diastolic dysfunction (LVDD) was defined if patients had E/e'≥15, or E/e'=9-14 accompanied by left atrial volume/BSA≥32ml/mm(2). Urinary samples were collected for type IV collagen and albumin, and blood samples were taken for BNP and HbA1c. Urinary type IV collagen and albumin increased in parallel with the deterioration of glycemic status. In hypertensive patients with prediabetes, subjects with LVDD had higher levels of BNP and urinary type IV collagen than those without LVDD. In contrast, in hypertensive patients with diabetes, subjects with LVDD had higher urinary albumin and BNP than those without LVDD. Urinary type IV collagen correlated positively with BNP in hypertensive patients with prediabetes, whereas it correlated with HbA1c in those with diabetes. In hypertensive patients with prediabetes, urinary type IV collagen was associated with LV diastolic dysfunction and BNP. Copyright © 2014 Elsevier Inc. All rights reserved.

The ratio of right ventricular volume to left ventricular volume reflects the impact of pulmonary regurgitation independently of the method of pulmonary regurgitation quantification

Energy Technology Data Exchange (ETDEWEB)

Śpiewak, Mateusz, E-mail: mspiewak@ikard.pl [Department of Coronary Artery Disease and Structural Heart Diseases, Institute of Cardiology, Warsaw (Poland); Cardiac Magnetic Resonance Unit, Institute of Cardiology, Warsaw (Poland); Małek, Łukasz A., E-mail: lmalek@ikard.pl [Cardiac Magnetic Resonance Unit, Institute of Cardiology, Warsaw (Poland); Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw (Poland); Petryka, Joanna, E-mail: joannapetryka@hotmail.com [Department of Coronary Artery Disease and Structural Heart Diseases, Institute of Cardiology, Warsaw (Poland); Cardiac Magnetic Resonance Unit, Institute of Cardiology, Warsaw (Poland); Mazurkiewicz, Łukasz, E-mail: lmazurkiewicz@ikard.pl [Cardiac Magnetic Resonance Unit, Institute of Cardiology, Warsaw (Poland); Department of Cardiomyopathy, Institute of Cardiology, Warsaw (Poland); Miłosz, Barbara, E-mail: barbara-milosz@o2.pl [Cardiac Magnetic Resonance Unit, Institute of Cardiology, Warsaw (Poland); Department of Radiology, Institute of Cardiology, Warsaw (Poland); Biernacka, Elżbieta K., E-mail: kbiernacka@ikard.pl [Department of Congenital Heart Diseases, Institute of Cardiology, Warsaw (Poland); Kowalski, Mirosław, E-mail: mkowalski@ikard.pl [Department of Congenital Heart Diseases, Institute of Cardiology, Warsaw (Poland); Hoffman, Piotr, E-mail: phoffman@ikard.pl [Department of Congenital Heart Diseases, Institute of Cardiology, Warsaw (Poland); Demkow, Marcin, E-mail: mdemkow@ikard.pl [Department of Coronary Artery Disease and Structural Heart Diseases, Institute of Cardiology, Warsaw (Poland); Miśko, Jolanta, E-mail: jmisko@wp.pl [Cardiac Magnetic Resonance Unit, Institute of Cardiology, Warsaw (Poland); Department of Radiology, Institute of Cardiology, Warsaw (Poland); Rużyłło, Witold, E-mail: wruzyllo@ikard.pl [Institute of Cardiology, Warsaw (Poland)

2012-10-15

Background: Previous studies have advocated quantifying pulmonary regurgitation (PR) by using PR volume (PRV) instead of commonly used PR fraction (PRF). However, physicians are not familiar with the use of PRV in clinical practice. The ratio of right ventricle (RV) volume to left ventricle volume (RV/LV) may better reflect the impact of PR on the heart than RV end-diastolic volume (RVEDV) alone. We aimed to compare the impact of PRV and PRF on RV size expressed as either the RV/LV ratio or RVEDV (mL/m{sup 2}). Methods: Consecutive patients with repaired tetralogy of Fallot were included (n = 53). PRV, PRF and ventricular volumes were measured with the use of cardiac magnetic resonance. Results: RVEDV was more closely correlated with PRV when compared with PRF (r = 0.686, p < 0.0001, and r = 0.430, p = 0.0014, respectively). On the other hand, both PRV and PRF showed a good correlation with the RV/LV ratio (r = 0.691, p < 0.0001, and r = 0.685, p < 0.0001, respectively). Receiver operating characteristic analysis showed that both measures of PR had similar ability to predict severe RV dilatation when the RV/LV ratio-based criterion was used, namely the RV/LV ratio > 2.0 [area under the curve (AUC){sub PRV} = 0.770 vs AUC{sub PRF} = 0.777, p = 0.86]. Conversely, with the use of the RVEDV-based criterion (>170 mL/m{sup 2}), PRV proved to be superior over PRF (AUC{sub PRV} = 0.770 vs AUC{sub PRF} = 0.656, p = 0.0028]. Conclusions: PRV and PRF have similar significance as measures of PR when the RV/LV ratio is used instead of RVEDV. The RV/LV ratio is a universal marker of RV dilatation independent of the method of PR quantification applied (PRF vs PRV)

Tank Waste Remediation System, Hanford Site, Richland, Washington. Final Environmental Impact Statement. Volume II

International Nuclear Information System (INIS)

1996-08-01

This document, Volume 2, provides the inventory of waste addressed in this Final Environmental Impact Statement (EIS) for the Tank Waste Remediation System, Hanford Site, Richland, Washington. The inventories consist of waste from the following four groups: (1) Tank waste; (2) Cesium (Cs) and Strontium (Sr) capsules; (3) Inactive miscellaneous underground storage tanks (MUSTs); and (4) Anticipated future tank waste additions. The major component by volume of the overall waste is the tank waste inventory (including future tank waste additions). This component accounts for more than 99 percent of the total waste volume and approximately 70 percent of the radiological activity of the four waste groups identified previously. Tank waste data are available on a tank-by-tank basis, but the accuracy of these data is suspect because they primarily are based on historical records of transfers between tanks rather than statistically based sampling and analyses programs. However, while the inventory of any specific tank may be suspect, the overall inventory for all of the tanks combined is considered more accurate. The tank waste inventory data are provided as the estimated overall chemical masses and radioactivity levels for the single-shell tanks (SSTs) and double-shell tanks (DSTs). The tank waste inventory data are broken down into tank groupings or source areas that were developed for analyzing groundwater impacts

Transuranium perrhenates: Np(IV), Pu(IV) and (III), Am (III)

International Nuclear Information System (INIS)

Silvestre, Jean-Paul; Freundlich, William; Pages, Monique

1977-01-01

Synthesis in aqueous solution and by solid state reactions, crystallographical characterization and study of the stability of some transuranium perrhenates: Asup(n+)(ReO 4 - )sub(n) (A=Np(IV), Pu(IV), Pu(III), Am(III) [fr

OCCUPATIONAL EDUCATION--PLANNING AND PROGRAMMING. VOLUME TWO.

Science.gov (United States)

KOTZ, ARNOLD

ADDITIONAL POSITION PAPERS BASED ON INFORMATION GATHERED IN THE RECONNAISSANCE SURVEYS OF PLANNING AND PROGRAMING IN OCCUPATIONAL EDUCATION, REPORTED IN VOLUME ONE (VT 005 041), ARE PRESENTED. PART IV, CONCERNED WITH PROGRAM STRUCTURE AND BUDGETING AND THEIR RELATION TO THE PLANNING PROCESS, INCLUDES THE PAPERS--(1) "CURRENT POLICIES AND…

Impact of Different CT Slice Thickness on Clinical Target Volume for 3D Conformal Radiation Therapy

International Nuclear Information System (INIS)

Prabhakar, Ramachandran; Ganesh, Tharmar; Rath, Goura K.; Julka, Pramod K.; Sridhar, Pappiah S.; Joshi, Rakesh C.; Thulkar, Sanjay

2009-01-01

The purpose of this study was to present the variation of clinical target volume (CTV) with different computed tomography (CT) slice thicknesses and the impact of CT slice thickness on 3-dimensional (3D) conformal radiotherapy treatment planning. Fifty patients with brain tumors were selected and CT scans with 2.5-, 5-, and 10-mm slice thicknesses were performed with non-ionic contrast enhancement. The patients were selected with tumor volume ranging from 2.54 cc to 222 cc. Three-dimensional treatment planning was performed for all three CT datasets. The target coverage and the isocenter shift between the treatment plans for different slice thickness were correlated with the tumor volume. An important observation from our study revealed that for volume 25 cc, the target underdosage was less than 6.7% for 5-mm slice thickness and 8% for 10-mm slice thickness. For 3D conformal radiotherapy treatment planning (3DCRT), a CT slice thickness of 2.5 mm is optimum for tumor volume 25 cc

Update of Part 61 Impacts Analysis Methodology. Methodology report. Volume 1

International Nuclear Information System (INIS)

Oztunali, O.I.; Roles, G.W.

1986-01-01

Under contract to the US Nuclear Regulatory Commission, the Envirosphere Company has expanded and updated the impacts analysis methodology used during the development of the 10 CFR Part 61 rule to allow improved consideration of the costs and impacts of treatment and disposal of low-level waste that is close to or exceeds Class C concentrations. The modifications described in this report principally include: (1) an update of the low-level radioactive waste source term, (2) consideration of additional alternative disposal technologies, (3) expansion of the methodology used to calculate disposal costs, (4) consideration of an additional exposure pathway involving direct human contact with disposed waste due to a hypothetical drilling scenario, and (5) use of updated health physics analysis procedures (ICRP-30). Volume 1 of this report describes the calculational algorithms of the updated analysis methodology

Update of Part 61 Impacts Analysis Methodology. Methodology report. Volume 1

Energy Technology Data Exchange (ETDEWEB)

Oztunali, O.I.; Roles, G.W.

1986-01-01

Under contract to the US Nuclear Regulatory Commission, the Envirosphere Company has expanded and updated the impacts analysis methodology used during the development of the 10 CFR Part 61 rule to allow improved consideration of the costs and impacts of treatment and disposal of low-level waste that is close to or exceeds Class C concentrations. The modifications described in this report principally include: (1) an update of the low-level radioactive waste source term, (2) consideration of additional alternative disposal technologies, (3) expansion of the methodology used to calculate disposal costs, (4) consideration of an additional exposure pathway involving direct human contact with disposed waste due to a hypothetical drilling scenario, and (5) use of updated health physics analysis procedures (ICRP-30). Volume 1 of this report describes the calculational algorithms of the updated analysis methodology.

De Minimis waste impacts analysis methodology. IMPACTS - BRC user's guide and methodology for radioactive wastes below regulatory concern. Draft report for comment. Volume 2

International Nuclear Information System (INIS)

Forstom, J.M.; Goode, D.J.

1986-07-01

This report describes the methodology and computer program used by NRC to evaluate radiological impacts associated with petitions to have specific slightly contaminated radioactive waste streams designated as ''below regulatory concern.'' These wastes could be treated and disposed of at facilities which are not licensed for low-level radioactive waste management. The IMPACTS-BRC computer program is implemented on IBM-PC microcomputers using the FORTRAN programming language. Radiological impacts (doses) are estimated for several pathways including direct gamma radiation exposure, worker inhalation and exposure, offsite atmospheric and water releases, and intruder exposures. Annual impacts are calculated for the maximum individual, critical groups, and general population. The treatment and disposal options include onsite incineration, incineration at municipal and hazardous waste facilities, and disposal at sanitary landfills and hazardous waste landfills. Modifications to the program (from Volume 1) are primarily for microcomputer compatibility and to provide information needed to evaluate the petitions. Default environmental and facility parameters are developed representing conservative assumptions about site selection and operational procedures. In particular, the parameters of the groundwater pathway model are modified to represent more conservative assumptions than the original model (Volume 1)

IMAGE information monitoring and applied graphics software environment. Volume 4. Applications description

International Nuclear Information System (INIS)

Hallam, J.W.; Ng, K.B.; Upham, G.L.

1986-09-01

The EPRI Information Monitoring and Applied Graphics Environment (IMAGE) system is designed for 'fast proto-typing' of advanced concepts for computer-aided plant operations tools. It is a flexible software system which can be used for rapidly creating, dynamically driving and evaluating advanced operator aid displays. The software is written to be both host computer and graphic device independent. This four volume report includes an Executive Overview of the IMAGE package (Volume 1), followed by Software Description (Volume II), User's Guide (Volume III), and Description of Example Applications (Volume IV)

Mass Spectrometric Studies of Reductive Elimination from Pd(IV) Complexes

Czech Academy of Sciences Publication Activity Database

Hývl, Jakub; Roithová, J.

2014-01-01

Roč. 16, č. 1 (2014), s. 200-203 ISSN 1523-7060 Grant - others:GA ČR(CZ) GAP207/11/0338 Institutional support: RVO:61388963 Keywords : cross - coupling reactions * oxidative addition * palladium(IV) Subject RIV: CC - Organic Chemistry Impact factor: 6.364, year: 2014

Coordination and solvent extraction behaviour of oxozirconium(IV), thorium(IV) and dioxouranium(VI)

International Nuclear Information System (INIS)

Dash, K.C.

1989-01-01

The systematic liquid-liquid extraction behaviour of oxozirconium (IV), thorium(IV) and dioxouranium(VI) have been investigated using a number of synthesised and commercial chelating extractants. The synergism or antagonism for these processes in presence of neutral donor ligands have also been identified and the conditions for separation and isolation of pure individual metal ions have been established. The coordination behaviour of oxozirconium(IV), thorium(IV) and dioxouranium(VI) with a large number of mono- and polydentate ligands have been studied. With oxozirconium(IV), invariably always a cyclic, tetranuclear species is obtained, derived from the tetrameric structure of the parent ZrOCl 2 .8H 2 O which is actually (Zr 4 (OH) 8 (H 2 O) 16 )Cl 8 .12H 2 O. No simple, monomeric oxozirconium(IV) complex was obtained. Uranium(VI) and thorium(IV) form a wide variety of complexes of higher coordination numbers and several bi- and trinuclear complexes were also characterised where the two adjacent metal centres are joined to each other by a double hydroxo-bridge. (author). 69 refs., 3 figs., 4 tabs

Study of electrolytic reduction of uranium VI to uranium IV in nitrate systems

Energy Technology Data Exchange (ETDEWEB)

Araujo, B.F. de; Almeida, S.G. de; Forbicini, S; Matsuda, H T; Araujo, J.A. de [Instituto de Pesquisas Energeticas e Nucleares, Sao Paulo (Brazil). Centro de Engenharia Quimica

1980-01-01

Experimental parameters are optimized in order to obtain uranium (IV) nitrate solutions at maximum yield, using hydrazine as stabilizer. Uranium (VI) electrolytic reduction was chosen because: there is no increase in the volume of radioactive effluents; there are no secondary reactions; there is no need for further separations; all reagents used are not inflammable. The method is, therefore, efficient and of low cost.

Final Programmatic Environmental Impact Statement for stockpile stewardship and management: Volume 3

International Nuclear Information System (INIS)

1996-09-01

The Department of Energy (DOE) has been directed by the President and Congress to maintain the safety and reliability of the reduced nuclear weapons stockpile in the absence of underground nuclear testing. In order to fulfill that responsibility, DOE has developed a Stockpile Stewardship and Management Program to provide a single highly integrated technical program for maintaining the continued safety and reliability of the nuclear stockpile. The Stockpile Stewardship and Management Programmatic Environmental Impact Statement (PEIS) describes and analyzes alternative ways to implement the proposed actions for the Stockpile Stewardship and Management Program. This document consists of Volume III, Appendix I entitled ''National Ignition Facility Project-Specific Analysis,'' which investigates the environmental impacts resulting from constructing and operating the proposed National Ignition Facility

PROGRAM HTVOL: The Determination of Tree Crown Volume by Layers

Science.gov (United States)

Joseph C. Mawson; Jack Ward Thomas; Richard M. DeGraaf

1976-01-01

A FORTRAN IV computer program calculates, from a few field measurements, the volume of tree crowns. This volume is in layers of a specified thickness of trees or large shrubs. Each tree is assigned one of 15 solid forms, formed by using one of five side shapes (a circle, an ellipse, a neiloid, a triangle, or a parabolalike shape), and one of three bottom shapes (a...

Impact of an electronic health record operating room management system in ophthalmology on documentation time, surgical volume, and staffing.

Science.gov (United States)

Sanders, David S; Read-Brown, Sarah; Tu, Daniel C; Lambert, William E; Choi, Dongseok; Almario, Bella M; Yackel, Thomas R; Brown, Anna S; Chiang, Michael F

2014-05-01

Although electronic health record (EHR) systems have potential benefits, such as improved safety and quality of care, most ophthalmology practices in the United States have not adopted these systems. Concerns persist regarding potential negative impacts on clinical workflow. In particular, the impact of EHR operating room (OR) management systems on clinical efficiency in the ophthalmic surgery setting is unknown. To determine the impact of an EHR OR management system on intraoperative nursing documentation time, surgical volume, and staffing requirements. For documentation time and circulating nurses per procedure, a prospective cohort design was used between January 10, 2012, and January 10, 2013. For surgical volume and overall staffing requirements, a case series design was used between January 29, 2011, and January 28, 2013. This study involved ophthalmic OR nurses (n = 13) and surgeons (n = 25) at an academic medical center. Electronic health record OR management system implementation. (1) Documentation time (percentage of operating time documenting [POTD], absolute documentation time in minutes), (2) surgical volume (procedures/time), and (3) staffing requirements (full-time equivalents, circulating nurses/procedure). Outcomes were measured during a baseline period when paper documentation was used and during the early (first 3 months) and late (4-12 months) periods after EHR implementation. There was a worsening in total POTD in the early EHR period (83%) vs paper baseline (41%) (P system implementation was associated with worsening of intraoperative nursing documentation time especially in shorter procedures. However, it is possible to implement an EHR OR management system without serious negative impacts on surgical volume and staffing requirements.

Role of solution chemistry on the trapping of radionuclide Th(IV) using titanate nanotubes as an efficient adsorbent

International Nuclear Information System (INIS)

Guodong Sheng; Chinese Academy of Sciences, Hefei; Baowei Hu

2013-01-01

Titanate nanotubes (TNTs) have attracted great interest in multidisciplinary study since their discovery. The adsorption of thorium [Th(IV)] onto TNTs in the absence and presence of humic acid (HA)/fulvic acid (FA) was studied by batch technique. The influence of pH from 2.0 to 10.0, ionic strength from 0.001 to 0.1 mol L -1 NaClO 4 , and coexisting electrolyte cations (Li + , Na + , K + ) and anions (ClO 4 - , NO 3 - , Cl - ) on the adsorption of Th(IV) onto TNTs was tested. The adsorption isotherms of Th(IV) was determined at pH 3.0 and analyzed with Langmuir and Freundlich adsorption models, respectively. The results demonstrated that the adsorption of Th(IV) onto TNTs increases steeply with increasing pH from 2.0 to 4.0. Generally, HA/FA was showed to enhance Th(IV) adsorption onto TNTs at low pH values, but to reduce Th(IV) adsorption onto TNTs at high pH values. The adsorption of Th(IV) onto TNTs was also dependent on coexisting electrolyte ions in aqueous solution under our experimental conditions. The adsorption of Th(IV) onto TNTs is exothermic and spontaneous. The findings indicating that TNTs can be used as a promising candidate for the enrichment and solidification of Th(IV) or its analogue actinides from large volume solution in real work. (author)

Impact of removed tumor volume and location on patient outcome in glioblastoma.

Science.gov (United States)

Awad, Al-Wala; Karsy, Michael; Sanai, Nader; Spetzler, Robert; Zhang, Yue; Xu, Yizhe; Mahan, Mark A

2017-10-01

Glioblastoma is an aggressive primary brain tumor with devastatingly poor prognosis. Multiple studies have shown the benefit of wider extent of resection (EOR) on patient overall survival (OS) and worsened survival with larger preoperative tumor volumes. However, the concomitant impact of postoperative tumor volume and eloquent location on OS has yet to be fully evaluated. We performed a retrospective chart review of adult patients treated for glioblastoma from January 2006 through December 2011. Adherence to standardized postoperative chemoradiation protocols was used as an inclusion criterion. Detailed volumetric and location analysis was performed on immediate preoperative and immediate postoperative magnetic resonance imaging. Cox proportional hazard modeling approach was employed to explore the modifying effects of EOR and eloquent location after adjusting for various confounders and associated characteristics, such as preoperative tumor volume and demographics. Of the 471 screened patients, 141 were excluded because they did not meet all inclusion criteria. The mean (±SD) age of the remaining 330 patients (60.6% male) was 58.9 ± 12.9 years; the mean preoperative and postoperative Karnofsky performance scores (KPSs) were 76.2 ± 10.3 and 80.0 ± 16.6, respectively. Preoperative tumor volume averaged 33.2 ± 29.0 ml, postoperative residual was 4.0 ± 8.1 ml, and average EOR was 88.6 ± 17.6%. The observed average follow-up was 17.6 ± 15.7 months, and mean OS was 16.7 ± 14.4 months. Survival analysis showed significantly shorter survival for patients with lesions in periventricular (16.8 ± 1.7 vs. 21.5 ± 1.4 mo, p = 0.03), deep nuclei/basal ganglia (11.6 ± 1.7 vs. 20.6 ± 1.2, p = 0.002), and multifocal (12.0 ± 1.4 vs. 21.3 ± 1.3 months, p = 0.0001) locations, but no significant influence on survival was seen for eloquent cortex sites (p = 0.14, range 0.07-0.9 for all individual

The Absence of Fever Is Associated With Higher Mortality and Decreased Antibiotic and IV Fluid Administration in Emergency Department Patients With Suspected Septic Shock.

Science.gov (United States)

Henning, Daniel J; Carey, Jeremy R; Oedorf, Kimie; Day, Danielle E; Redfield, Colby S; Huguenel, Colin J; Roberts, Jonathan C; Sanchez, Leon D; Wolfe, Richard E; Shapiro, Nathan I

2017-06-01

This study evaluates whether emergency department septic shock patients without a fever (reported or measured) receive less IV fluids, have decreased antibiotic administration, and suffer increased in-hospital mortality. This was a secondary analysis of a prospective, observational study of patients with shock. The study was conducted in an urban, academic emergency department. The original study enrolled consecutive adult (aged 18 yr or older) emergency department patients from November 11, 2012, to September 23, 2013, who met one of the following shock criteria: 1) systolic blood pressure less than 90 mm Hg after at least 1L IV fluids, 2) new vasopressor requirement, or 3) systolic blood pressure less than 90 mm Hg and IV fluids held for concern of fluid overload. The current study is limited to patients with septic shock. Patients were grouped as febrile if they had a subjective fever or a measured temperature >100.4°F documented in the emergency department; afebrile patients lacked both. Among 378 patients with septic shock, 207 of 378 (55%; 50-60%) were febrile by history or measurement. Afebrile patients had lower rates of antibiotic administration in the emergency department (81% vs 94%; p < 0.01), lower mean volumes of IV fluids (2,607 vs 3,013 mL; p < 0.01), and higher in-hospital mortality rates (33% vs 11%; p < 0.01). After adjusting for bicarbonate less than 20 mEq/L, lactate concentration, respiratory rate greater than or equal to 24 breaths/min, emergency department antibiotics, and emergency department IV fluids volume, being afebrile remained a significant predictor of in-hospital mortality (odds ratio, 4.3; 95% CI, 2.2-8.2; area under the curve = 0.83). In emergency department patients with septic shock, afebrile patients received lower rates of emergency department antibiotic administration, lower mean IV fluids volume, and suffered higher in-hospital mortality.

Application of volume of fluid method for simulation of a droplet impacting a fiber

Directory of Open Access Journals (Sweden)

M. Khalili

2016-06-01

Full Text Available In the present work, impact of a Newtonian drop on horizontal thin fibers with circular cross section is simulated in 2D views. The numerical simulations of the phenomena are carried out using volume of fluid (VOF method for tracking the free surface motion. Impacting of a Newtonian droplet on a circular thin fiber (350μm radius investigated numerically. The main focus of this simulation is to acquire threshold radius and velocity of a drop which is entirely captured by the fiber. The model agrees well with the experiments and demonstrates the threshold radius decreased generally with the increase of impact velocity. In other words, for velocity larger than threshold velocity of capture perhaps only a small portion of fluid is stuck on the solid and the rest of the drop is ejected for impact velocity smaller than critical velocity the drop is totally captured. This threshold velocity has been determined when the impact is centered.

Synthesis and characterization of chiral thorium(IV) and uranium(IV) benzamidinate complexes

Energy Technology Data Exchange (ETDEWEB)

Schoene, Sebastian; Maerz, Juliane; Kaden, Peter; Patzschke, Michael; Ikeda-Ohno, Atsushi [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Chemistry of the F-Elements

2017-06-01

Two chiral benzamidinate complexes of tetravalent actinides (Th(IV) and U(IV)) were synthesized using a salt metathesis reaction of the corresponding actinide(IV) tetrachlorides and the potassium salt of the chiral benzamidine (S,S)-N,N-Bis-(1-phenylethyl)-benzamidine ((S)-HPEBA). The structure of the complexes was determined with single crystal X-ray diffraction. These are the first examples of chiral amidinate complexes of actinides.

Volume transmission-mediated encephalopathies: a possible new concept?

Science.gov (United States)

Hartung, Hans-Peter; Dihné, Marcel

2012-03-01

There is strong evidence that the composition of cerebrospinal fluid (CSF) influences brain development, neurogenesis, and behavior. The bidirectional exchange of CSF and interstitial fluid (ISF) across the ependymal and pia-glial membranes is required for these phenomena to occur. Because ISF surrounds the parenchymal compartment, neuroactive substances in the CSF and ISF can influence neuronal activity. Functionally important neuroactive substances are distributed to distant sites of the central nervous system by the convection and diffusion of CSF and ISF, a process known as volume transmission. It has recently been shown that pathologically altered CSF from patients with acute traumatic brain injury suppresses in vitro neuronal network activity (ivNNA) recorded by multielectrode arrays measuring synchronously bursting neural populations. Functionally relevant substances in pathologically altered CSF have been biochemically identified, and ivNNA has been partially recovered by pharmacologic intervention. It remains unclear whether the in vivo parenchymal compartment remains unaffected by pathologically altered CSF that significantly impairs ivNNA. We hypothesize that pathologic CSF alterations are not just passive indicators of brain diseases but that they actively and directly evoke functional disturbances in global brain activity through the distribution of neuroactive substances, for instance, secondary to focal neurologic disease. For this mechanism, we propose the new term volume transmission-mediated encephalopathies (VTE). Recording ivNNA in the presence of pure human CSF could help to identify and monitor functionally relevant CSF alterations that directly result in VTEs, and the collected data might point to therapeutic ways to antagonize these alterations.

Päiväkoti Riemula

OpenAIRE

Alanko, Reetta; Ihanamäki, Katja

2012-01-01

Opinnäytetyössä kuvataan yleisesti päivähoidon kehitystä Suomessa sekä päivähoitoa yrittäjän näkökulmasta, tuoden esille sen tämän päivän haasteet ja mahdollisuudet. Työssä on pohdittu yhteistyön merkitystä kunnan kanssa ja sitä, miten kunta voi osaltaan joko rajoittaa tai edesauttaa yksityisen päivähoitoyrityksen toimintaa. Opinnäytetyössä kerrotaan teoriassa Päiväkoti Riemula nimisen, erityispäivähoitopalveluita tarjoavan yrityksen perustamiseen liittyvistä suunnitelmista. Suunnitelluss...

Space Assembly, Maintenance and Servicing Study. Volume 4: Concept Development Plan

National Research Council Canada - National Science Library

1986-01-01

.... This concept development program (CDP), Volume IV of the SAMS final report, contains a summary of the selection of CDP candidates and a plan for completing the required analysis, tests and demonstrations...

Rectal compliance as a routine measurement: extreme volumes have direct clinical impact and normal volumes exclude rectum as a problem.

Science.gov (United States)

Felt-Bersma, R J; Sloots, C E; Poen, A C; Cuesta, M A; Meuwissen, S G

2000-12-01

The clinical impact of rectal compliance and sensitivity measurement is not clear. The aim of this study was to measure the rectal compliance in different patient groups compared with controls and to establish the clinical effect of rectal compliance. Anorectal function tests were performed in 974 consecutive patients (284 men). Normal values were obtained from 24 controls. Rectal compliance measurement was performed by filling a latex rectal balloon with water at a rate of 60 ml per minute. Volume and intraballoon pressure were measured. Volume and pressure at three sensitivity thresholds were recorded for analysis: first sensation, urge, and maximal toleration. At maximal toleration, the rectal compliance (volume/pressure) was calculated. Proctoscopy, anal manometry, anal mucosal sensitivity, and anal endosonography were also performed as part of our anorectal function tests. No effect of age or gender was observed in either controls or patients. Patients with fecal incontinence had a higher volume at first sensation and a higher pressure at maximal toleration (P = 0.03), the presence of a sphincter defect or low or normal anal pressures made no difference. Patients with constipation had a larger volume at first sensation and urge (P 500 ml had complaints of constipation. No correlation between rectal and anal mucosal sensitivity was found. Rectal compliance measurement with a latex balloon is easily feasible. In this series of 974 patients, some patient groups showed an abnormal rectal visceral sensitivity and compliance, but there was an overlap with controls. Rectal compliance measurement gave a good clinical impression about the contribution of the rectum to the anorectal problem. Patients with proctitis and pouchitis had the smallest rectal compliance. A maximal toleration volume 500 ml was only seen in constipated patients, and therapy should be given to prevent further damage to the pelvic floor. Values close to or within the normal range rule out the

Estimating the cost-per-result of a national reflexed Cryptococcal antigenaemia screening program: Forecasting the impact of potential HIV guideline changes and treatment goals.

Science.gov (United States)

Cassim, Naseem; Coetzee, Lindi Marie; Schnippel, Kathryn; Glencross, Deborah Kim

2017-01-01

During 2016, the National Health Laboratory Service (NHLS) introduced laboratory-based reflexed Cryptococcal antigen (CrAg) screening to detect early Cryptococcal disease in immunosuppressed HIV+ patients with a confirmed CD4 count of 100 cells/μl or less. The aim of this study was to assess cost-per-result of a national screening program across different tiers of laboratory service, with variable daily CrAg test volumes. The impact of potential ART treatment guideline and treatment target changes on CrAg volumes, platform choice and laboratory workflow are considered. CD4 data (with counts per-result was calculated for four scenarios, including the existing service status quo (Scenario-I), and three other settings (as Scenarios II-IV) which were based on information from recent antiretroviral (ART) guidelines, District Health Information System (DHIS) data and UNAIDS 90/90/90 HIV/AIDS treatment targets. Scenario-II forecast CD4 testing offered only to new ART initiates recorded at DHIS. Scenario-III projected all patients notified as HIV+, but not yet on ART (recorded at DHIS) and Scenario-IV forecast CrAg screening in 90% of estimated HIV+ patients across South Africa (also DHIS). Stata was used to assess daily CrAg volumes at the 5th, 10th, 25th, 50th, 75th, 90th and 95th percentiles across 52 CD4-laboratories. Daily volumes were used to determine technical effort/ operator staff costs (% full time equivalent) and cost-per-result for all scenarios. Daily volumes ranged between 3 and 64 samples for Scenario-I at the 5th and 95th percentile. Similarly, daily volumes ranges of 1-12, 2-45 and 5-100 CrAg-directed samples were noted for Scenario's II, III and IV respectively. A cut-off of 30 CrAg tests per day defined use of either LFA or EIA platform. LFA cost-per-result ranged from $8.24 to $5.44 and EIA cost-per-result between $5.58 and $4.88 across the range of test volumes. The technical effort across scenarios ranged from 3.2-27.6% depending on test volumes and

IV access in dental practice.

LENUS (Irish Health Repository)

Fitzpatrick, J J

2009-04-01

Intravenous (IV) access is a valuable skill for dental practitioners in emergency situations and in IV sedation. However, many people feel some apprehension about performing this procedure. This article explains the basic principles behind IV access, and the relevant anatomy and physiology, as well as giving a step-by-step guide to placing an IV cannula.

Impact of surgical volume on functional results and cardiospecific survival rates in patients with clinically localized renal cancer

Directory of Open Access Journals (Sweden)

M. I. Volkova

2014-11-01

Full Text Available Objective: to analyze the impact of surgical volume on functional results and cardiospecific survival rates in patients with clinically localized renal carcinoma.Subjects and methods. Four hundred and fifty-three patients with pT1–3aN0M0 renal cell carcinoma and normally functioning secondkidney who had undergone radical nephrectomy (n = 226 (49.9 % or kidney resection (n = 227 (50.1 % were selected for the investigation. The patient groups who had undergone different-volume operations were matched for gender, age, body mass index (BMI, side of involvement, tumor sizes, and baseline glomerular filtration rate (GFR (p > for all. The median baseline Charlson index and the rate of ASA classes III–IV operative risk were significantly higher in candidates for radical nephrectomy (p < 0.05 for all, the rate of diseases affecting kidney function, pT1a category, and G1 anaplasia were higher in the kidney resection group (p < 0.0001. The median follow-up was 50 (12–224 months.Results. Within 28 days postsurgery, the rate of acute renal dysfunction (ARD was 36.2 %. The independent risk factors of ARD were kidney resection (risk ratio (RR = 0.210; 95 % confidence interval (CI 0.115–0.288; р < 0.0001 and ischemia time (RR = 0.012; 95 % CI 0.004–0.021; p = 0.004. The degree of ARD after kidney resection was significantly lower than that following radical nephrectomy (p < 0.0001. In the late postoperative period, the incidence of chronic kidney disease (CKD Stage ≥ III was 38.4 %. Its independent risk factors were low baseline GFR (RR = 0.003; 95 % CI 0.002–0.005; p < 0.0001, radical nephrectomy (RR = 0.195; 95 % CI 0.093–0.298; p < 0.0001, and ARD (RR = 0.281; 95 % CI 0.187–0.376; p = 0.0001. Ten-year specific and cardiospecific survival rates in all the patients were 98.5 and 94.9 %, respectively, and unrelated to surgical volume. The independent predictors of poor cardiospecific survival were BMI, Charlson index, and ASA risk

Impact of surgical volume on functional results and cardiospecific survival rates in patients with clinically localized renal cancer

Directory of Open Access Journals (Sweden)

M. I. Volkova

2014-01-01

Full Text Available Objective: to analyze the impact of surgical volume on functional results and cardiospecific survival rates in patients with clinically localized renal carcinoma.Subjects and methods. Four hundred and fifty-three patients with pT1–3aN0M0 renal cell carcinoma and normally functioning secondkidney who had undergone radical nephrectomy (n = 226 (49.9 % or kidney resection (n = 227 (50.1 % were selected for the investigation. The patient groups who had undergone different-volume operations were matched for gender, age, body mass index (BMI, side of involvement, tumor sizes, and baseline glomerular filtration rate (GFR (p > for all. The median baseline Charlson index and the rate of ASA classes III–IV operative risk were significantly higher in candidates for radical nephrectomy (p < 0.05 for all, the rate of diseases affecting kidney function, pT1a category, and G1 anaplasia were higher in the kidney resection group (p < 0.0001. The median follow-up was 50 (12–224 months.Results. Within 28 days postsurgery, the rate of acute renal dysfunction (ARD was 36.2 %. The independent risk factors of ARD were kidney resection (risk ratio (RR = 0.210; 95 % confidence interval (CI 0.115–0.288; р < 0.0001 and ischemia time (RR = 0.012; 95 % CI 0.004–0.021; p = 0.004. The degree of ARD after kidney resection was significantly lower than that following radical nephrectomy (p < 0.0001. In the late postoperative period, the incidence of chronic kidney disease (CKD Stage ≥ III was 38.4 %. Its independent risk factors were low baseline GFR (RR = 0.003; 95 % CI 0.002–0.005; p < 0.0001, radical nephrectomy (RR = 0.195; 95 % CI 0.093–0.298; p < 0.0001, and ARD (RR = 0.281; 95 % CI 0.187–0.376; p = 0.0001. Ten-year specific and cardiospecific survival rates in all the patients were 98.5 and 94.9 %, respectively, and unrelated to surgical volume. The independent predictors of poor cardiospecific survival were BMI, Charlson index, and ASA risk

Impacts of future climate change on urban flood volumes in Hohhot in northern China: benefits of climate change mitigation and adaptations

Science.gov (United States)

Zhou, Qianqian; Leng, Guoyong; Huang, Maoyi

2018-01-01

As China becomes increasingly urbanised, flooding has become a regular occurrence in its major cities. Assessing the effects of future climate change on urban flood volumes is crucial to informing better management of such disasters given the severity of the devastating impacts of flooding (e.g. the 2016 flooding events across China). Although recent studies have investigated the impacts of future climate change on urban flooding, the effects of both climate change mitigation and adaptation have rarely been accounted for together in a consistent framework. In this study, we assess the benefits of mitigating climate change by reducing greenhouse gas (GHG) emissions and locally adapting to climate change by modifying drainage systems to reduce urban flooding under various climate change scenarios through a case study conducted in northern China. The urban drainage model - Storm Water Management Model - was used to simulate urban flood volumes using current and two adapted drainage systems (i.e. pipe enlargement and low-impact development, LID), driven by bias-corrected meteorological forcing from five general circulation models in the Coupled Model Intercomparison Project Phase 5 archive. Results indicate that urban flood volume is projected to increase by 52 % over 2020-2040 compared to the volume in 1971-2000 under the business-as-usual scenario (i.e. Representative Concentration Pathway (RCP) 8.5). The magnitudes of urban flood volumes are found to increase nonlinearly with changes in precipitation intensity. On average, the projected flood volume under RCP 2.6 is 13 % less than that under RCP 8.5, demonstrating the benefits of global-scale climate change mitigation efforts in reducing local urban flood volumes. Comparison of reduced flood volumes between climate change mitigation and local adaptation (by improving drainage systems) scenarios suggests that local adaptation is more effective than climate change mitigation in reducing future flood volumes. This has

Influence of the Metal Volume Fraction on the maximum deflection and impact load of GLARE plates subjected to low velocity impact

Science.gov (United States)

Bikakis, GSE; Savaidis, A.; Zalimidis, P.; Tsitos, S.

2016-11-01

Fiber-metal laminates are hybrid composite materials, consisting of alternating metal layers bonded to fiber-reinforced prepreg layers. GLARE (GLAss REinforced) belongs to this new family of materials. GLARE is the most successful fiber-metal laminate up to now and is currently being used for the construction of primary aerospace structures, such as the fuselage of the Airbus A380 air plane. Impact properties are very important in aerospace structures, since impact damage is caused by various sources, such as maintenance damage from dropped tools, collision between service cars or cargo and the structure, bird strikes and hail. The principal objective of this article is to evaluate the influence of the Metal Volume Fraction (MVF) on the low velocity impact response of GLARE fiber-metal laminates. Previously published differential equations of motion are employed for this purpose. The low velocity impact behavior of various circular GLARE plates is predicted and characteristic values of impact variables, which represent the impact phenomenon, are evaluated versus the corresponding MVF of the examined GLARE material grades. The considered GLARE plates are subjected to low velocity impact under identical impact conditions. A strong effect of the MVF on the maximum impact load and a significant effect on the maximum plate deflection of GLARE plates has been found.

Studies of the effects of organic materials on the sorption of uranium(IV) and thorium(IV) on London clay and Caithness flagstones

International Nuclear Information System (INIS)

Baston, G.M.N.; Berry, J.A.; Bond, K.A.; Brownsword, M.; Linklater, C.M.

1991-08-01

The effects of the presence of cellulosic degradation products on the sorption of uranium (IV) and thorium(IV) on London clay and Caithness flagstones have been studied using the batch sorption method. Experimental conditions were chosen to simulate both those expected close to a cementitious repository (pH ∼11) and at the edge of the zone of migration of the alkaline plume (pH ∼ 8). Work was carried out (i) under baseline conditions, in the absence of organic materials; (ii) with 2 x 10 -3 M gluconate, acting as a well-characterised degradation product simulant; (iii) with authentic degradation products. The results show that the presence of authentic degradation products has a small effect on sorption and the presence of gluconate at a high concentration has a marked impact. (author)

Studies of the effects of organic materials on the sorption of uranium(IV) and thorium(IV) on London clay and Caithness flagstones

Energy Technology Data Exchange (ETDEWEB)

Baston, G.M.N.; Berry, J.A.; Bond, K.A.; Brownsword, M.; Linklater, C.M.

1991-08-01

The effects of the presence of cellulosic degradation products on the sorption of uranium (IV) and thorium(IV) on London clay and Caithness flagstones have been studied using the batch sorption method. Experimental conditions were chosen to simulate both those expected close to a cementitious repository (pH {approx}11) and at the edge of the zone of migration of the alkaline plume (pH {approx} 8). Work was carried out (i) under baseline conditions, in the absence of organic materials; (ii) with 2 x 10{sup -3}M gluconate, acting as a well-characterised degradation product simulant; (iii) with authentic degradation products. The results show that the presence of authentic degradation products has a small effect on sorption and the presence of gluconate at a high concentration has a marked impact. (author).

Complexation of the An(IV) by NTA; Complexation des An(IV) par le NTA

Energy Technology Data Exchange (ETDEWEB)

Bonin, L. [Paris-11 Univ., 91 - Orsay (France)]|[CEA Valrho, Lab. de Chimie des Actinides (LCA), 30 - Marcoule (France)

2006-07-01

In the framework of the Nuclear and Environmental Toxicology program, developed in France, it has been decided to take again the studies concerning the actinides decorporation. A similar study of the neptunium complexation by the citrate ions has been carried out on the complexation of Np(IV) with the nitrilotriacetic acid (NTA). The NTA can be considered as a model molecule of the de-corporating molecules (amino-carboxy- ligand). The results of the spectrophotometric measurements being encouraging, the behaviour of several actinides at the same oxidation state (+IV) (Th(IV), U(IV), Np(IV), and Pu(IV)) has been determined. The experimental results are presented. In order to determine the structure of the complexes of stoichiometry 1:2 An(IV)-(NTA){sub 2} in solution, quantic chemistry calculations and EXAFS measurements have been carried out in parallel. These studies confirm the presence of An(IV)-nitrogen bonds whose length decreases from thorium to plutonium and indicate the presence of a water molecule bound to the thorium and the uranium (coordination number 8 for Np/Pu, 9 for Th/U). The evolution of the complexation constants determined in this study in terms of 1/r (r ionic radius of the cation taking into account its coordination number 8 or 9) confirms the change of the coordination number between Th/U and Np/Pu. (O.M.)

Epigenetic and antitumor effects of platinum (IV)-octanoato conjugates

Czech Academy of Sciences Publication Activity Database

Novohradský, Vojtěch; Zanellato, I.; Marzano, C.; Prachařová, J.; Kašpárková, Jana; Gibson, D.; Gandin, V.; Osella, D.; Brabec, Viktor

2017-01-01

Roč. 7, JUN2017 (2017), č. článku 3751. ISSN 2045-2322 R&D Projects: GA ČR(CZ) GA17-09436S; GA ČR(CZ) GA17-05302S Institutional support: RVO:68081707 Keywords : cancer-cell apoptosis * pt(iv) prodrugs * dna hypermethylation Subject RIV: FD - Oncology ; Hematology OBOR OECD: Oncology Impact factor: 4.259, year: 2016

Oceanic Area System Improvement Study (OASIS). Volume IV. Caribbean Region Air Traffic Services System Description.

Science.gov (United States)

1981-09-01

OASIS) U Final Report This report i.s one of a set of companion documents which includes the following volumes: Volume I Executive Summary and...Northern Coastal Region of 4 the Directorate of Engineering and Systems (Direccion de Ingenieria y Sistemas ), which is responsible for maintenance of the

Adsorption recovery of thorium(IV) by Myrica rubra tannin and larch tannin immobilized onto collagen fibres

International Nuclear Information System (INIS)

Xuepin Liao; Li Li; Bi Shi

2004-01-01

Novel adsorbents which can concentrate Th(IV) in aqueous solution were prepared by immobilizing Myrica rubra tannin and larch tannin onto collagen fibre matrices. The adsorption capacities of the immobilized tannins to Th(IV) are related to temperature and pH value of the adsorption process. For example, when the initial concentration of Th(IV) was 116.0 mg x l -1 and the immobilized tannin was 100 mg, the adsorption capacities of immobilized Myrica rubra tannin and larch tannin were 55.98 mg Th(IV) x g -1 and 13.19 mg Th(IV) x g -1 , respectively at 303 K, and 73.67 mg Th(IV) x g -1 and 18.19 mg Th(IV) x g -1 at 323 K. It was also found that the higher adsorption capacity was obtained at higher pH value. The adsorption equilibrium data of the immobilized tannins for Th(IV) can be well fitted by the Langmuir model and the mechanism of the adsorption was found to be a chemical adsorption. In general, the adsorption capacity of immobilized Myrica rubra tannin to Th(IV) is significantly higher than that of immobilized larch tannin, probably due to the fact that the B ring of Myrica rubra tannin has a pyrogallol structure which has higher reaction activity with metal ions. The breakthrough point of the adsorption column of immobilized Myrica rubra tannin was at 33 bed volumes for the experimental system. The mass transfer coefficient of adsorption column determined by Adams-Bohart equation was 1.61 x 10 -4 l x mg -1 x min -1 . The adsorption column can be easily regenerated by 0.1 mol x l -1 HNO 3 solution, showing outstanding ability of concentrating Th(IV). (author)

The impact of a forced reduction in traffic volumes on urban air pollution

International Nuclear Information System (INIS)

Yuval; Broday, D.M.

2008-01-01

The Middle East military conflict of summer 2006 resulted in a few weeks in which the city of Haifa, Israel, and its environs experienced very profound variations in the commercial and personal activities. Large industrial plants continued almost normal operations but activities of small scale industry, shopping, and personal commuting were drastically reduced, leading to a dramatic decrease in the commercial and personal traffic volumes. This period of reduced activity serves as a real life experiment for assessment and demonstration of the impact that human activity, and mainly road traffic, may have on the air pollution levels in a bustling middle-sized city. The analysis is made especially sharp and reliable due to the abruptness of the beginning and the end of the reduced activity period, its length, and the stable summer meteorological conditions in the eastern Mediterranean region. The reduced traffic volumes resulted in lowered levels of NO 2 , hydrocarbons and particulate matter. The decrease in these pollutants' mean concentration was significantly larger than the reduction in the mean traffic volume. Slightly higher mean O 3 concentrations were observed during the reduced traffic period. (author)

Hydride generation atomic fluorescence spectrometric determination of As, Bi, Sb, Se(IV) and Te(IV) in aqua regia extracts from atmospheric particulate matter using multivariate optimization

International Nuclear Information System (INIS)

Moscoso-Perez, Carmen; Moreda-Pineiro, Jorge; Lopez-Mahia, Purificacion; Muniategui-Lorenzo, Soledad; Fernandez-Fernandez, Esther; Prada-Rodriguez, Dario

2004-01-01

A highly sensitive and simple method, based on hydride generation and atomic fluorescence detection, has been developed for the determination of As, Bi, Sb, Se(IV) and Te(IV) in aqua regia extracts from atmospheric particulate matter samples. Atmospheric particulates matter was collected on glass fiber filters using a medium volume sampler (PM1 particulate matter). Two-level factorial designs have been used to optimise the hydride generation atomic fluorescence spectrometry (HG-AFS) procedure. The effects of several parameters affecting the hydride generation efficiency (hydrochloric acid, sodium tetrahydroborate and potassium iodide concentrations and flow rates) have been evaluated using a Plackett-Burman experimental design. In addition, parameters affecting the hydride measurement (delay, analysis and memory times) have been also investigated. The significant parameters obtained (sodium tetrahydroborate concentration, sodium tetrahydroborate flow rate and analysis time for As; hydrochloric acid concentration and sodium tetrahydroborate flow rate for Se(IV); and sodium tetrahydroborate concentration and sodium tetrahydroborate flow rate for Te(IV)) have been optimized by using 2 n + star central composite design. Hydrochloric acid concentration and sodium tetrahydroborate flow rate were the significant parameters obtained for Sb and Bi determination, respectively. Using a univariate approach these parameters were optimized. The accuracy of methods have been verified by using several certified reference materials: SRM 1648 (urban particulate matter) and SRM 1649a (urban dust). Detection limits in the range of 6 x 10 -3 to 0.2 ng m -3 have been achieved. The developed methods were applied to several atmospheric particulate matter samples corresponding to A Coruna city (NW Spain)

Assessing indoor air quality options: Final environmental impact statement on new energy-efficient home programs: Volume 2

International Nuclear Information System (INIS)

1988-03-01

This report discusses the impact of energy conservation measures on indoor air quality in various size residential buildings. This volume includes appendices on ventilation rates, indoor pollutant levels, health effects, human risk assessment, radon, fiberglass hazards, tobacco smoke, mitigation

Mi Carrera. Volume IV: Effective Career Planning with Hispanic High School Students.

Science.gov (United States)

Douglas, Denise, Ed.

This curriculum guide, the fourth of a four-volume set that is intended to improve career and vocational guidance services to Spanish-speaking students in grades 9 through 12, is actually a collection of three different resources. The first section, "Group Activities: Intercambios," by Maria Garcia, is a model culturally based group counseling…

FORMALIZING PRODUCT COST DISTORTION: The Impact of Volume-Related Allocation Bases on Cost Information

Directory of Open Access Journals (Sweden)

Johnny Jermias

2003-09-01

Full Text Available The purpose o f this study is to formally analyze product cost distortions resulting from the process of allocating costs to products based on Activity-Based Costing (ABC and the conventional product costing systems. The model developed in this paper rigorously shows the impact of treating costs that are not volume related as if they are. The model demonstrates that the source of product cost distortion is the difference between the proportion of driver used by each product in ABC and the proportion of the base used by the same product in the conventional costing systems. The difference arises because the conventional costing systems ignore the existence of batch-related and product-related costs. The model predicts a positive association between volume and size diversity with product cost distortions. When interaction between volume and size diversity exists, the distortion is either mitigated or exacerbated. The magnitude of the distortion is jointly determined by the size of the differences and the size of the total indirect costs.

West Hackberry Strategic Petroleum Reserve site brine-disposal monitoring, Year I report. Volume IV. Bibliography and supporting data for physical oceanography. Final report. [421 references

Energy Technology Data Exchange (ETDEWEB)

DeRouen, L.R.; Hann, R.W.; Casserly, D.M.; Giammona, C.; Lascara, V.J. (eds.)

1983-02-01

This project centers around the Strategic Petroleum Site (SPR) known as the West Hackberry salt dome which is located in southwestern Louisiana and which is designed to store 241 million barrels of crude oil. Oil storage caverns are formed by injecting water into salt deposits, and pumping out the resulting brine. Studies described in this report were designed as follow-on studies to three months of pre-discharge characterization work, and include data collected during the first year of brine leaching operations. The objectives were to: (1) characterize the environment in terms of physical, chemical and biological attributes; (2) determine if significant adverse changes in ecosystem productivity and stability of the biological community are occurring as a result of brine discharge; and (3) determine the magnitude of any change observed. Volume IV contains the following: bibliography; appendices for supporting data for physical oceanography, and summary of the physical oceanography along the western Louisiana coast.

Technical Reports (Part II). End of Project Report, 1968-1971, Volume IV.

Science.gov (United States)

Western Nevada Regional Education Center, Lovelock.

The pamphlets included in this volume are technical reports prepared as outgrowths of the Student Information System of the Western Nevada Regional Education Center funded by a Title III grant under the Elementary and Secondary Education Act of 1965. These reports demonstrate the use of the stored data; methods of interpreting the printouts from…

Proceedings of the Malaysian Science and Technology Congress 2000: Symposium B,Volume IV

International Nuclear Information System (INIS)

2001-01-01

This proceedings is a collection of lectures presented at this symposium. This volume covers the following areas - biodiversity, cleaner production, green science, environment, renewable resources, social sciences, waste management and basic sciences

Structural study of bis(triorganotin(IV)) esters of 4-ketopimelic acid

Czech Academy of Sciences Publication Activity Database

Chalupa, J.; Handlíř, K.; Císařová, I.; Jirásko, R.; Brus, Jiří; Lyčka, A.; Růžička, A.; Holeček, J.

2006-01-01

Roč. 691, č. 12 (2006), s. 2631-2640 ISSN 0022-328X R&D Projects: GA ČR GA203/03/1118 Institutional research plan: CEZ:AV0Z40500505 Keywords : triorganotin(IV) esters * ketopimelic acid * NMR Subject RIV: CD - Macromolecular Chemistry Impact factor: 2.332, year: 2006

Astragaloside IV Prevents Cardiac Remodeling in the Apolipoprotein E-Deficient Mice by Regulating Cardiac Homeostasis and Oxidative Stress

Directory of Open Access Journals (Sweden)

Xiong-Zhi Li

2017-12-01

Full Text Available Background: Hypercholesterolemia is a risk factor for the development of cardiac hypertrophy. Astragaloside IV (AST-IV possesses cardiovascular protective properties. We hypothesize that AST-IV prevents cardiac remodeling with hypercholesterolemia via modulating tissue homeostasis and alleviating oxidative stress. Methods: The ApoE-/- mice were treated with AST-IV at 1 or 10 mg/kg for 8 weeks. The blood lipids tests, echocardiography, and TUNEL were performed. The mRNA expression profile was detected by real-time PCR. The myocytes size and number, and the expressions of proliferation (ki67, senescence (p16INK4a, oxidant (NADPH oxidase 4, NOX4 and antioxidant (superoxide dismutase, SOD were observed by immunofluorescence staining. Results: Neither 1 mg/kg nor 10 mg/kg AST-IV treatment could decrease blood lipids in ApoE-/- mice. However, the decreased left ventricular ejection fraction (LVEF and fractional shortening (FS in ApoE–/– mice were significantly improved after AST-IV treatment. The cardiac collagen volume fraction declined nearly in half after AST-IV treatment. The enlarged myocyte size was suppressed, and myocyte number was recovered, and the alterations of genes expressions linked to cell cycle, proliferation, senescence, p53-apoptosis pathway and oxidant-antioxidants in the hearts of ApoE-/- mice were reversed after AST-IV treatment. The decreased ki67 and increased p16INK4a in the hearts of ApoE-/- mice were recovered after AST-IV treatment. The percentages of apoptotic myocytes and NOX4-positive cells in AST-IV treated mice were decreased, which were consistent with the gene expressions. Conclusion: AST-IV treatment could prevent cardiac remodeling and recover the impaired ventricular function induced by hypercholesterolemia. The beneficial effect of AST-IV might partly be through regulating cardiac homeostasis and anti-oxidative stress.

Superconducting Super Collider: Final environmental impact statement: Volume 2, Comment/response document: Summary and index

International Nuclear Information System (INIS)

1988-12-01

This volume is divided into five parts as follows: Summary and Index; Letters submitted by commenters in response to the Draft Environmental Impact Statement (DEIS) from date of issue through October 17, 1988; Transcripts of testimony at the public hearings conducted by the DOE in the vicinity of each site alternative; Letters postmarked after October 17, 1988; and Comment responses to both the letters and the testimony. This summary and index is published as a guide to the reader in reviewing this document. The summary is of the approximately 7000 comments received by the DOE from a total of about 5700 commenters. It was prepared as a general reference and guide to the readers of this volume. The Index follows the summary. The first index is an alphabetical listing of commenters (of both letters and transcripts) and indicates the number each commenter was assigned. The commenter numbers guide the reader to DOE comment responses in Volume 2B which are in numerical order

Specificity of abnormal brain volume in major depressive disorder: a comparison with borderline personality disorder.

Science.gov (United States)

Depping, Malte S; Wolf, Nadine D; Vasic, Nenad; Sambataro, Fabio; Thomann, Philipp A; Christian Wolf, R

2015-03-15

Abnormal brain volume has been frequently demonstrated in major depressive disorder (MDD). It is unclear if these findings are specific for MDD since aberrant brain structure is also present in disorders with depressive comorbidity and affective dysregulation, such as borderline personality disorder (BPD). In this transdiagnostic study, we aimed to investigate if regional brain volume loss differentiates between MDD and BPD. Further, we tested for associations between brain volume and clinical variables within and between diagnostic groups. 22 Females with a DSM-IV diagnosis of MDD, 17 females with a DSM-IV diagnosis of BPD and without comorbid posttraumatic stress disorder, and 22 age-matched female healthy controls (HC) were investigated using magnetic resonance imaging. High-resolution structural data were analyzed using voxel-based morphometry. A significant (pdisorders. Copyright © 2014 Elsevier B.V. All rights reserved.

FINESSE: study of the issues, experiments and facilities for fusion nuclear technology research and development. Interim report. Volume IV

International Nuclear Information System (INIS)

Abdou, M.

1984-10-01

This volume contains the following chapters (1) neutronics tests, (2) fluence considerations, (3) instrumentation and test matrix, (4) non-neutron test stands, (5) accelerator-based point neutron sources, (6) utilization of fission reactors, (7) tandem mirror test facilities, (8) tokamak fusion test facilities, (9) reliability development testing impacts on fusion reactor availability, and (10) fusion development scenarios. In addition, the following appendices are included: (1) evaluation of experience from fast breeder reactors, (2) observations of experts from the fission field, (3) evaluation of experience from the aerospace industry, (4) characterization of fusion nuclear systems operating environment, (5) modelling of MFTF-α+T high gamma mode performance, and (6) small-scale, multiple effects testing at US/DOE breeder reactor in-pile facilities

Magnetic resonance imaging assessment of the ventricular system in the brains of adult and juvenile beagle dogs treated with posaconazole IV Solution.

Science.gov (United States)

Hines, C D G; Song, X; Kuruvilla, S; Farris, G; Markgraf, C G

2015-01-01

Noxafil® (posaconazole; POS) is a potent, selective triazole antifungal approved for use in adults as an oral suspension, oral tablet and intravenous (IV) Solution. In support of pediatric administration of POS IV Solution to childrentwo years of age, two studies were undertaken using magnetic resonance imaging (MRI) to monitor brain ventricle size longitudinally during three months administration of POS IV in adult and juvenile dogs. Necropsy was performed on all animals at the end of the studies. From the baseline MRI images, great variability in ventricle size was noted in both the adult and juvenile dogs; these images were used to distribute differently sized ventricles between treatment and vehicle groups as to not skew group means during the course of the study. POS IV Solution had no effect on ventricle volume at any timepoint during dosing in either the adult or the juvenile dogs. Further, no gross or histomorphologic differences between groups were observed in either study. Compared to juvenile dogs, MRI analysis showed that adult dogs had larger ventricles, lower variability in all ventricle volumes, and a greater rate of increase in total ventricle volume. Information on growth and development of brains is one of the few areas in which more detailed information is available about humans than about the standard laboratory animals used to model disease and predict toxicities. The use of MRI helped elucidate large natural variabilities in the dog brain, which could have altered the interpretation of this de-risking study, and provided a valuable noninvasive means to monitor the brain ventricles longitudinally. Copyright © 2015 Elsevier Inc. All rights reserved.

Proposed Tenaska Washington II Generation Project : Final Environmental Impact Statement. Volume 2: Public Involvement.

Energy Technology Data Exchange (ETDEWEB)

United States. Bonneville Power Administration.

1994-01-01

In regard to the proposed Tenaska Washington II Generation Project, the goal of the Bonneville Power Administration`s (BPA) Environmental Impact Statement (EIS) public involvement process is to determine the issues to be examined and pertinent analyses to be conducted and to solicit comments on the content and quality of information presented in the Draft Environmental Impact Statement (DEIS). Comments and questions are solicited from the public and government agencies during the scoping process and during the comment period and public hearing on the DEIS, to find out what is of most concern to them. The end product of the public involvement process is the Comment Report which follows in part of this volume on Public Involvement.

Impacts of future climate change on urban flood volumes in Hohhot in northern China: benefits of climate change mitigation and adaptations

Directory of Open Access Journals (Sweden)

Q. Zhou

2018-01-01

Full Text Available As China becomes increasingly urbanised, flooding has become a regular occurrence in its major cities. Assessing the effects of future climate change on urban flood volumes is crucial to informing better management of such disasters given the severity of the devastating impacts of flooding (e.g. the 2016 flooding events across China. Although recent studies have investigated the impacts of future climate change on urban flooding, the effects of both climate change mitigation and adaptation have rarely been accounted for together in a consistent framework. In this study, we assess the benefits of mitigating climate change by reducing greenhouse gas (GHG emissions and locally adapting to climate change by modifying drainage systems to reduce urban flooding under various climate change scenarios through a case study conducted in northern China. The urban drainage model – Storm Water Management Model – was used to simulate urban flood volumes using current and two adapted drainage systems (i.e. pipe enlargement and low-impact development, LID, driven by bias-corrected meteorological forcing from five general circulation models in the Coupled Model Intercomparison Project Phase 5 archive. Results indicate that urban flood volume is projected to increase by 52 % over 2020–2040 compared to the volume in 1971–2000 under the business-as-usual scenario (i.e. Representative Concentration Pathway (RCP 8.5. The magnitudes of urban flood volumes are found to increase nonlinearly with changes in precipitation intensity. On average, the projected flood volume under RCP 2.6 is 13 % less than that under RCP 8.5, demonstrating the benefits of global-scale climate change mitigation efforts in reducing local urban flood volumes. Comparison of reduced flood volumes between climate change mitigation and local adaptation (by improving drainage systems scenarios suggests that local adaptation is more effective than climate change mitigation in reducing

Final waste management programmatic environmental impact statement for managing treatment, storage, and disposal of radioactive and hazardous waste. Volume IV of V

International Nuclear Information System (INIS)

1997-01-01

The Final Waste Management Programmatic Environmental Impact Statement (WM PEIS) examines the potential environmental and cost impacts of strategic management alternatives for managing five types of radioactive and hazardous wastes that have resulted and will continue to result from nuclear defense and research activities at a variety of sites around the United States. The five waste types are low-level mixed waste, low-level waste, transuranic waste, high-level waste, and hazardous waste. The WM PEIS provides information on the impacts of various siting alternatives which the Department of Energy (DOE) will use to decide at which sites to locate additional treatment, storage, and disposal capacity for each waste type.Transportation is an integral component of the alternatives being considered for each type of radioactive waste in the U.S. Department of Energy (DOE) Waste Management Programmatic Environmental Impact Statement (WM PEIS). The types of radioactive waste considered in Part I are high-level waste (HLW), low-level waste (LLW), transuranic waste (TRUW), and low-level mixed waste (LLMW). For some alternatives, radioactive waste would be shipped among the DOE sites at various stages of the treatment, storage, and disposal (TSD) process. The magnitude of the transportation-related activities varies with each alternative, ranging from minimal transportation for decentralized approaches to significant transportation for some centralized approaches. The human health risks associated with transporting various waste materials were assessed to ensure a complete appraisal of the impacts of each PEIS alternative being considered

Comparative Analysis of Inpatient Costs for Obstetrics and Gynecology Surgery Patients Treated With IV Acetaminophen and IV Opioids Versus IV Opioid-only Analgesia for Postoperative Pain.

Science.gov (United States)

Hansen, Ryan N; Pham, An T; Lovelace, Belinda; Balaban, Stela; Wan, George J

2017-10-01

Recovery from obstetrics and gynecology (OB/GYN) surgery, including hysterectomy and cesarean section delivery, aims to restore function while minimizing hospital length of stay (LOS) and medical expenditures. Our analyses compare OB/GYN surgery patients who received combination intravenous (IV) acetaminophen and IV opioid analgesia with those who received IV opioid-only analgesia and estimate differences in LOS, hospitalization costs, and opioid consumption. We performed a retrospective analysis of the Premier Database between January 2009 and June 2015, comparing OB/GYN surgery patients who received postoperative pain management with combination IV acetaminophen and IV opioids with those who received only IV opioids starting on the day of surgery and continuing up to the second postoperative day. We performed instrumental variable 2-stage least-squares regressions controlling for patient and hospital covariates to compare the LOS, hospitalization costs, and daily opioid doses (morphine equivalent dose) of IV acetaminophen recipients with that of opioid-only analgesia patients. We identified 225 142 OB/GYN surgery patients who were eligible for our study of whom 89 568 (40%) had been managed with IV acetaminophen and opioids. Participants averaged 36 years of age and were predominantly non-Hispanic Caucasians (60%). Multivariable regression models estimated statistically significant differences in hospitalization cost and opioid use with IV acetaminophen associated with $484.4 lower total hospitalization costs (95% CI = -$760.4 to -$208.4; P = 0.0006) and 8.2 mg lower daily opioid use (95% CI = -10.0 to -6.4), whereas the difference in LOS was not significant, at -0.09 days (95% CI = -0.19 to 0.01; P = 0.07). Compared with IV opioid-only analgesia, managing post-OB/GYN surgery pain with the addition of IV acetaminophen is associated with decreased hospitalization costs and reduced opioid use.

Mexico City air quality research initiative. Volume IV. Characterization and measurement

Energy Technology Data Exchange (ETDEWEB)

Mauzy, A. [ed.

1994-04-01

This volume describes the methods and the data gathered in an attempt to measure and characterize the meteorological factors and the concentration of different pollutants in the Mexico City Metropolitan Area. The main objective of this document was to provide input for the simulation models and to obtain information that could be used to test and improve the models` performance. Four field campaigns were conducted, as well as routine monitoring, in order to obtain a database of atmospheric dynamics and air pollution characteristics. Sections include Airborne measurements, Remote sensing measurements, and Traditional (in situ) measurements.

X-Band Electron Paramagnetic Resonance Comparison of Mononuclear Mn(IV)-oxo and Mn(IV)-hydroxo Complexes and Quantum Chemical Investigation of Mn(IV) Zero-Field Splitting.

Science.gov (United States)

Leto, Domenick F; Massie, Allyssa A; Colmer, Hannah E; Jackson, Timothy A

2016-04-04

X-band electron paramagnetic resonance (EPR) spectroscopy was used to probe the ground-state electronic structures of mononuclear Mn(IV) complexes [Mn(IV)(OH)2(Me2EBC)](2+) and [Mn(IV)(O)(OH)(Me2EBC)](+). These compounds are known to effect C-H bond oxidation reactions by a hydrogen-atom transfer mechanism. They provide an ideal system for comparing Mn(IV)-hydroxo versus Mn(IV)-oxo motifs, as they differ by only a proton. Simulations of 5 K EPR data, along with analysis of variable-temperature EPR signal intensities, allowed for the estimation of ground-state zero-field splitting (ZFS) and (55)Mn hyperfine parameters for both complexes. From this analysis, it was concluded that the Mn(IV)-oxo complex [Mn(IV)(O)(OH)(Me2EBC)](+) has an axial ZFS parameter D (D = +1.2(0.4) cm(-1)) and rhombicity (E/D = 0.22(1)) perturbed relative to the Mn(IV)-hydroxo analogue [Mn(IV)(OH)2(Me2EBC)](2+) (|D| = 0.75(0.25) cm(-1); E/D = 0.15(2)), although the complexes have similar (55)Mn values (a = 7.7 and 7.5 mT, respectively). The ZFS parameters for [Mn(IV)(OH)2(Me2EBC)](2+) were compared with values obtained previously through variable-temperature, variable-field magnetic circular dichroism (VTVH MCD) experiments. While the VTVH MCD analysis can provide a reasonable estimate of the magnitude of D, the E/D values were poorly defined. Using the ZFS parameters reported for these complexes and five other mononuclear Mn(IV) complexes, we employed coupled-perturbed density functional theory (CP-DFT) and complete active space self-consistent field (CASSCF) calculations with second-order n-electron valence-state perturbation theory (NEVPT2) correction, to compare the ability of these two quantum chemical methods for reproducing experimental ZFS parameters for Mn(IV) centers. The CP-DFT approach was found to provide reasonably acceptable values for D, whereas the CASSCF/NEVPT2 method fared worse, considerably overestimating the magnitude of D in several cases. Both methods were poor in

High Statistics Analysis using Anisotropic Clover Lattices: (IV) The Volume Dependence of the Light Hadron Masses

Energy Technology Data Exchange (ETDEWEB)

Beane, S R; Detmold, W; Lin, H W; Luu, T C; Orginos, K; Parreno, A; Savage, M J; Torok, A; Walker-Loud, A

2011-07-01

The volume dependence of the octet baryon masses and relations among them are explored with Lattice QCD. Calculations are performed with nf = 2 + 1 clover fermion discretization in four lattice volumes, with spatial extent L ? 2.0, 2.5, 3.0 and 4.0 fm, with an anisotropic lattice spacing of b_s ? 0.123 fm in the spatial direction, and b_t = b_s/3.5 in the time direction, and at a pion mass of m_\\pi ? 390 MeV. The typical precision of the ground-state baryon mass determination is volume dependence of the masses, the Gell-Mann Okubo mass-relation, and of other mass combinations. A comparison with the predictions of heavy baryon chiral perturbation theory is performed in both the SU(2)L ? SU(2)R and SU(3)L ? SU(3)R expansions. Predictions of the three-flavor expansion for the hadron masses are found to describe the observed volume dependences reasonably well. Further, the ?N? axial coupling constant is extracted from the volume dependence of the nucleon mass in the two-flavor expansion, with only small modifications in the three-flavor expansion from the inclusion of kaons and eta's. At a given value of m?L, the finite-volume contributions to the nucleon mass are predicted to be significantly smaller at m_\\pi ? 140 MeV than at m_\\pi ? 390 MeV due to a coefficient that scales as ? m_\\pi^3. This is relevant for the design of future ensembles of lattice gauge-field configurations. Finally, the volume dependence of the pion and kaon masses are analyzed with two-flavor and three-flavor chiral perturbation theory.

NJOY nuclear data processing system. Volume IV. The ERRORR and COVR modules

International Nuclear Information System (INIS)

Muir, D.W.; MacFarlane, R.E.

1985-12-01

The NJOY nuclear data processing system is a comprehensive computer code package for producing cross sections and related nuclear parameters from ENDF/B evaluated nuclear data. This volume provides detailed descriptions of the NJOY modules ERRORR and COVR, which are concerned with the covariances (uncertainties and correlations) of multigroup cross sections and fission neutron yield (anti nu) values. 17 refs

The Canada country study: Climate impacts and adaptation -- Vol. 7: National sectoral volume

Energy Technology Data Exchange (ETDEWEB)

Koshida, G.; Avis, W. [eds.] [Environment Canada, Downsview, ON (Canada)

1998-10-01

The Canada Country Study is a comprehensive source of knowledge on how climate change could impact on communities across Canada. The Study consists of a series of eight volumes and constitutes the scientific and technical results of the assessment phase of the project. This volume (Vol. 7) contains 12 sectoral papers which provide a digest of the findings of the previous six regional volumes, but viewed from the vantage points of the various sectors of national life and the economy, i.e. (1) agriculture, (2) built environment, (3) energy, (4) fisheries, (5) forestry, (6) human health, (7) insurance, (8) recreation and tourism, (9) transportation, (10) unmanaged ecosystems, (11) water resources, and (12) wetlands. Each paper is accompanied by an extensive list of references, a list of tables, a list of figures, and a list of appendices. Readers are cautioned that confidence levels are higher in the hemispheric-to-continental projections of climate change than in the regional projections. Also, it should be borne in mind that the identified changes in climate are projected to occur over the next century, and that the average rate of warming used in the models underlying these projections may be greater than any seen in the last several millenia.

Final Programmatic Environmental Impact Statement for stockpile stewardship and management: Volume 1

International Nuclear Information System (INIS)

1996-09-01

The Department of Energy (DOE) has been directed by the President and Congress to maintain the safety and reliability of the reduced nuclear weapons stockpile in the absence of underground nuclear testing. In order to fulfill that responsibility, DOE has developed Stockpile Stewardship and Maintenance Program to provide a single highly integrated technical program for maintaining the continued safety and reliability of the nuclear stockpile. The Stockpile Stewardship and Management Program Programmatic Environmental Impact Statement (PEIS) describes and analyzes alternative ways to implement the proposed actions for the Stockpile Stewardship and Management Program. This document contains Volume I of the PEIS

IV treatment at home

Science.gov (United States)

... Other IV treatments you may receive after you leave the hospital include: Treatment for hormone deficiencies Medicines for severe nausea that cancer chemotherapy or pregnancy may cause Patient-controlled analgesia (PCA) for pain (this is IV ...

The Prognostic and Predictive Value of Soluble Type IV Collagen in Colorectal Cancer

DEFF Research Database (Denmark)

Rolff, Hans Christian; Christensen, Ib Jarle; Vainer, Ben

2016-01-01

PURPOSE: To investigate the prognostic and predictive biomarker value of type IV collagen in colorectal cancer. EXPERIMENTAL DESIGN: Retrospective evaluation of two independent cohorts of patients with colorectal cancer included prospectively in 2004-2005 (training set) and 2006-2008 (validation....... RESULTS: High levels of type IV collagen showed independent prognostic significance in both cohorts with hazard ratios (HRs; for a one-unit change on the log base 2 scale) of 2.25 [95% confidence intervals (CIs), 1.78-2.84; P ... and validation set, respectively. The prognostic impact was present both in patients with metastatic and nonmetastatic disease. The predictive value of the marker was investigated in stage II and III patients. In the training set, type IV collagen was prognostic both in the subsets of patients receiving...

Tethys and Annex IV Progress Report for FY 2012

Energy Technology Data Exchange (ETDEWEB)

Hanna, Luke A.; Butner, R. Scott; Whiting, Jonathan M.; Copping, Andrea E.

2013-09-01

The marine and hydrokinetic (MHK) environmental Impacts Knowledge Management System, dubbed “Tethys” after the mythical Greek titaness of the seas, is being developed by the Pacific Northwest National Laboratory (PNNL) to support the U.S. Department of Energy’s Wind and Water Power Program (WWPP). Functioning as a smart database, Tethys enables its users to identify key words or terms to help gather, organize and make available information and data pertaining to the environmental effects of MHK and offshore wind (OSW) energy development. By providing and categorizing relevant publications within a simple and searchable database, Tethys acts as a dissemination channel for information and data which can be utilized by regulators, project developers and researchers to minimize the environmental risks associated with offshore renewable energy developments and attempt to streamline the permitting process. Tethys also houses a separate content-related Annex IV data base with identical functionality to the Tethys knowledge base. Annex IV is a collaborative project among member nations of the International Energy Agency (IEA) Ocean Energy Systems – Implementing Agreement (OES-IA) that examines the environmental effects of ocean energy devices and projects. The U.S. Department of Energy leads the Annex IV working with federal partners such as the Federal Energy Regulatory Commission (FERC), the Bureau of Ocean Energy Management (BOEM), and the National Oceanic Atmospheric Administration (NOAA). While the Annex IV database contains technical reports and journal articles, it is primarily focused on the collection of project site and research study metadata forms (completed by MHK researchers and developers around the world, and collected by PNNL) which provide information on environmental studies and the current progress of the various international MHK developments in the Annex IV member nations. The purpose of this report is to provide a summary of the content

Fusion Engineering Device. Volume IV. Physics basis and physics R and D requirements

International Nuclear Information System (INIS)

1981-10-01

This volume covers the following issues: (1) confinement scaling, (2) cross section shaping, limits on B and q, (3) ion cyclotron heating, (4) neutral beam heating, (5) mechanical pump limiter, (6) poloidal divertor, and (7) non-divertor active impurity control

Kilowatt isotope power system, Phase II Plan. Volume IV. Teledyne FSCD vs GDS

Energy Technology Data Exchange (ETDEWEB)

1978-03-15

This Volume contains Teledyne's input to the Kilowatt Isotope Power System Phase II Plan. Included is a description of the Flight System Heat Generation System, Flight System Radiator, Thermal Insulation Stability, GDS Heat Generation System and GDS Radiator.

A cerium(IV)-carbon multiple bond

Energy Technology Data Exchange (ETDEWEB)

Gregson, Matthew; Lu, Erli; McMaster, Jonathan; Lewis, William; Blake, Alexander J.; Liddle, Stephen T. [Nottingham Univ. (United Kingdom). School of Chemistry

2013-12-02

Straightforward access to a cerium(IV)-carbene complex was provided by one-electron oxidation of an anionic ''ate'' cerium(III)-carbene precursor, thereby avoiding decomposition reactions that plague oxidations of neutral cerium(III) compounds. The cerium(IV)-carbene complex is the first lanthanide(IV)-element multiple bond and involves a twofold bonding interaction of two electron pairs between cerium and carbon. [German] Auf direktem Wege zu einem Cer(IV)-Carbenkomplex gelangt man durch die Einelektronenoxidation einer anionischen Carben-Cerat(III)-Vorstufe. So werden Zersetzungsprozesse vermieden, die die Oxidation neutraler Cer(III)-Verbindungen erschweren. Der Cer(IV)-Carbenkomplex enthaelt die erste Lanthanoid(IV)-Element-Mehrfachbindung; dabei binden Cer und Kohlenstoff ueber zwei Elektronenpaare.

SPORT AND EXERCISE PHYSIOLOGY TESTING Volume one: Sport Testing Volume two: Exercise and Clinical Testing

Directory of Open Access Journals (Sweden)

Edward M. Winter

2007-03-01

Full Text Available DESCRIPTION The objective of the book is to discuss the theoretical and practical aspects of physiological testing in exercise and sports which is essential to evaluate and monitor developing exercise performance for athletes and public health, and improving quality of life for patients.A board of leading sport and exercise physiologists and scientists are gathered to discuss physiological assessments that have proven validity and reliability, both in sport and health relevant issues. Incidentally, it updates the reader about the current subjects of physiological exertion testing in both research and clinical procedures. Both volumes individually cover the increasing number of available research and review publications, and theoretical explanations are supported by practical examples. A step-by-step and/or checklist method is used in appropriate sections which make the guides more user-friendly than most. PURPOSE The first volume is designed to help readers develop an understanding of the essential concepts of sport specific testing whereas the second volume aims at making the exercise and clinical specific testing comprehensible, dealing with both technical terms and the theories underlying the importance of these tests. AUDIENCE As Guidelines books of the British Association of Sport and Exercise Sciences, it will be of interest to a wide range of students, researchers and practitioners in the sport and exercise disciplines whether they work in the laboratory or in the field. FEATURES The first volume features immediate practical requirements particularly in sport testing. It is composed of five parts with detailed sub-sections in all of them. The topics of the parts are: i general principles, ii methodological issues, iii general procedures, iv sport specific procedures, v special populations.The second volume is also presented in five parts, again with sub-sections in all of them, but considering the requirements in clinical and exercise

Gulf of Mexico Sales 157 and 161: Central and western planning areas final environmental impact statement, Volume I: Sections I through IV.C

International Nuclear Information System (INIS)

1995-11-01

This Final Environmental Impact Statement (EIS) covers the proposed 1996 Gulf of Mexico OCS oil and gas lease sales [Central Gulf of Mexico Sale 157 (March 1996) and Western Gulf of Mexico Sale 161 (August 1996)]. This document includes the purpose and background of the proposed actions, the alternatives, the descriptions of the affected environment, and the potential environmental impacts of the proposed actions and alternatives. Proposed mitigating measures and their potential effects are analyzed, in addition to potential cumulative impacts resulting from proposed activities

Policy-induced market introduction of Generation IV reactor systems

International Nuclear Information System (INIS)

Heek, Aliki Irina van; Roelofs, Ferry

2011-01-01

Almost 10 years ago the U.S. Department of Energy (DOE) started the Generation IV Initiative (GenIV) with 9 other national governments with a positive ground attitude towards nuclear energy. Some of these Generation IV systems, like the fast reactors, are nearing the demonstration stage. The question on how their market introduction will be implemented becomes increasingly urgent. One main topic for future reactor technologies is the treatment of radioactive waste products. Technological solutions to this issue are being developed. One possible process is the transformation of long-living radioactive nuclides into short living ones; a process known as transmutation, which can be done in a nuclear reactor only. Various Generation IV reactor concepts are suitable for this process, and of these systems most experience has been gained with the sodium-cooled fast reactor (SFR). However, both these first generation SFR plants and their Generation IV successors are designed as electricity generating plants, and therefore supposed to be commercially viable in the electricity markets. Various studies indicate that the generation costs of a combined LWR-(S)FR nuclear generating park (LWR: light water reactor) will be higher than that of an LWR-only park. To investigate the effects of the deployment of the different reactors and fuel cycles on the waste produced, resources used and costs incurred as a function of time, a dynamic fuel cycle assessment is performed. This study will focus on the waste impact of the introduction of a fraction of fast reactors in the European nuclear reactor park with a cost increase as described in the previous paragraph. The nuclear fuel cycle scenario code DANESS is used for this, as well as the nuclear park model of the EU-27 used for the previous study. (orig.)

Identification of novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides in camel milk protein hydrolysates.

Science.gov (United States)

Nongonierma, Alice B; Paolella, Sara; Mudgil, Priti; Maqsood, Sajid; FitzGerald, Richard J

2018-04-01

Nine novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides (FLQY, FQLGASPY, ILDKEGIDY, ILELA, LLQLEAIR, LPVP, LQALHQGQIV, MPVQA and SPVVPF) were identified in camel milk proteins hydrolysed with trypsin. This was achieved using a sequential approach combining liquid chromatography tandem mass spectrometry (LC-MS/MS), qualitative/quantitative structure activity relationship (QSAR) and confirmatory studies with synthetic peptides. The most potent camel milk protein-derived DPP-IV inhibitory peptides, LPVP and MPVQA, had DPP-IV half maximal inhibitory concentrations (IC 50 ) of 87.0 ± 3.2 and 93.3 ± 8.0 µM, respectively. DPP-IV inhibitory peptide sequences identified within camel and bovine milk protein hydrolysates generated under the same hydrolysis conditions differ. This was linked to differences in enzyme selectivity for peptide bond cleavage of camel and bovine milk proteins as well as dissimilarities in their amino acid sequences. Camel milk proteins contain novel DPP-IV inhibitory peptides which may play a role in the regulation of glycaemia in humans. Copyright © 2017 Elsevier Ltd. All rights reserved.

Impacts of Traffic Noise and Traffic Volume on Birds of Roadside Habitats

Directory of Open Access Journals (Sweden)

Kirsten M. Parris

2009-06-01

Full Text Available Roadside habitats are important for a range of taxa including plants, insects, mammals, and birds, particularly in developed countries in which large expanses of native vegetation have been cleared for agriculture or urban development. Although roadside vegetation may provide suitable habitat for many species, resident animals can be exposed to high levels of traffic noise, visual disturbance from passing vehicles, and the risk of collision with cars and trucks. Traffic noise can reduce the distance over which acoustic signals such as song can be detected, an effect known as acoustic interference or masking. Studies from the northern hemisphere show that the singing behavior of birds changes in the presence of traffic noise. We investigated the impact of traffic noise and traffic volume on two species of birds, the Grey Shrike-thrush (Colluricincla harmonica and the Grey Fantail (Rhipidura fuliginosa, at 58 roadside sites on the Mornington Peninsula, southeastern Australia. The lower singing Grey Shrike-thrush sang at a higher frequency in the presence of traffic noise, with a predicted increase in dominant frequency of 5.8 Hz/dB of traffic noise, and a total effect size of 209 Hz. In contrast, the higher singing Grey Fantail did not appear to change its song in traffic noise. The probability of detecting each species on a visit to a site declined substantially with increasing traffic noise and traffic volume, with several lines of evidence supporting a larger effect of traffic noise. Traffic noise could hamper detection of song by conspecifics, making it more difficult for birds to establish and maintain territories, attract mates and maintain pair bonds, and possibly leading to reduced breeding success in noisy roadside habitats. Closing key roads during the breeding season is a potential, but untested, management strategy to protect threatened bird species from traffic noise and collision with vehicles at the time of year when they are most

Analysis of Skylab IV fluid mechanic science demonstration

Science.gov (United States)

Klett, M. G.; Bourgeois, S. V.

1975-01-01

Several science demonstrations performed on Skylab III and IV were concerned with the behavior of fluid drops free floating in microgravity. These demonstrations, with large liquid drops, included the oscillation, rotation, impact and coalescence, and air injection into the drops. Rayleigh's analysis of the oscillation of spherical drops of a liquid predicts accurately the effect of size and surface tension on the frequency of vibrated water globules in the Skylab demonstration. However, damping occurred much faster than predicted by Lamb's or Scriven's analyses of the damping time for spherical drops. The impact demonstrations indicated that a minimum velocity is necessary to overcome surface forces and effect a coalescence, but a precise criterion for the coalescence of liquids in low g could not be determined.

Cost analysis of surgically treated pressure sores stage III and IV.

Science.gov (United States)

Filius, A; Damen, T H C; Schuijer-Maaskant, K P; Polinder, S; Hovius, S E R; Walbeehm, E T

2013-11-01

Health-care costs associated with pressure sores are significant and their financial burden is likely to increase even further. The aim of this study was to analyse the direct medical costs of hospital care for surgical treatment of pressure sores stage III and IV. We performed a retrospective chart study of patients who were surgically treated for stage III and IV pressure sores between 2007 and 2010. Volumes of health-care use were obtained for all patients and direct medical costs were subsequently calculated. In addition, we evaluated the effect of location and number of pressure sores on total costs. A total of 52 cases were identified. Average direct medical costs in hospital were €20,957 for the surgical treatment of pressure sores stage III or IV; average direct medical costs for patients with one pressure sore on an extremity (group 1, n = 5) were €30,286, €10,113 for patients with one pressure sore on the trunk (group 2, n = 32) and €40,882 for patients with multiple pressure sores (group 3, n = 15). The additional costs for patients in group 1 and group 3 compared to group 2 were primarily due to longer hospitalisation. The average direct medical costs for surgical treatment of pressure sores stage III and IV were high. Large differences in costs were related to the location and number of pressure sores. Insight into the distribution of these costs allows identification of high-risk patients and enables the development of specific cost-reducing measures. Copyright © 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

Application of Compressible Volume of Fluid Model in Simulating the Impact and Solidification of Hollow Spherical ZrO2 Droplet on a Surface

Science.gov (United States)

Safaei, Hadi; Emami, Mohsen Davazdah; Jazi, Hamidreza Salimi; Mostaghimi, Javad

2017-12-01

Applications of hollow spherical particles in thermal spraying process have been developed in recent years, accompanied by attempts in the form of experimental and numerical studies to better understand the process of impact of a hollow droplet on a surface. During such process, volume and density of the trapped gas inside droplet change. The numerical models should be able to simulate such changes and their consequent effects. The aim of this study is to numerically simulate the impact of a hollow ZrO2 droplet on a flat surface using the volume of fluid technique for compressible flows. An open-source, finite-volume-based CFD code was used to perform the simulations, where appropriate subprograms were added to handle the studied cases. Simulation results were compared with the available experimental data. Results showed that at high impact velocities ( U 0 > 100 m/s), the compression of trapped gas inside droplet played a significant role in the impact dynamics. In such velocities, the droplet splashed explosively. Compressibility effects result in a more porous splat, compared to the corresponding incompressible model. Moreover, the compressible model predicted a higher spread factor than the incompressible model, due to planetary structure of the splat.

Complexes of uranium (IV) and thorium (IV) with α-picolinic acid, nicotinic acid, anthranilic acid and N-phenylanthranilic acid

International Nuclear Information System (INIS)

Singh, M.; Singh, R.

1979-01-01

Stable U(IV) and Th(IV) complexes with the title ligands have been synthesised from U(OAc) 4 , and Th(OAc) 4 . Magnetic susceptibilities, IR and reflectance spectra of U(IV) and IR spectra of Th(IV) complexes have been studied which indicate eight coordination for U(IV) in these chelates. (auth.)

Changes in Treatment Volume of Hormonally Treated and Untreated Cancerous Prostate and its Impact on Rectal Dose

International Nuclear Information System (INIS)

Lilleby, Wolfgang; Dale, Einar; Olsen, Dag R.; Gude, Unn; Fossaa, Sophie D.

2003-01-01

Late chronic side effects of the rectum constitute one of the principal limiting factors for curative radiation therapy in patients with prostate cancer. The purpose of the study was to determine the impact of immediate androgen deprivation (IAD) prior to conformal radiotherapy on rectal volume exposed to high doses, as compared with a deferred treatment strategy (DAD). Twenty-five patients (13 in the IAD group and 12 in the DAD group) with bulky tumours of the prostate, T3pN1-2M0 from the prospective EORTC trial 30846 were analysed. Three-dimensional conformal radiation treatment plans (3D CRT) using a 4-field box technique were generated based on the digitized computed tomographic or magnetic resonance findings acquired during the first 9 months after inclusion in the EORTC trial. Dose-volume histograms (DVHs) were calculated for the prostate and rectum. In the DAD group, there was no obvious alteration in the mean size of the prostate or other evaluated structures. In the IAD patients, a statistically significant reduction of approximately 40% of the gross tumour volume (GTV) was reached after a 6 months' course of hormonal treatment (p<0.001). High-dose rectal volume was correlated with the volume changes of the GTV (p<0.001). Mean rectal volume receiving 95% or more of the target dose was significantly reduced by 20%. Our study confirms the effect of downsizing of locally advanced prostate tumours following AD treatment and demonstrates the interdependence of the high-dose rectal volume with the volume changes of the GTV. However, the mean beneficial sparing of rectal volume was outweighed in some patients by considerable inter-patient variations

Amygdala and hippocampus volumes are differently affected by childhood trauma in patients with bipolar disorders and healthy controls.

Science.gov (United States)

Janiri, Delfina; Sani, Gabriele; Rossi, Pietro De; Piras, Fabrizio; Iorio, Mariangela; Banaj, Nerisa; Giuseppin, Giulia; Spinazzola, Edoardo; Maggiora, Matteo; Ambrosi, Elisa; Simonetti, Alessio; Spalletta, Gianfranco

2017-08-01

Volumetric studies on deep gray matter structures in bipolar disorder (BP) have reported contrasting results. Childhood trauma, a relevant environmental stressor for BP, could account for the variability of the results, modulating differences in the amygdala and hippocampus in patients with BP compared with healthy controls (HC). Our study aimed to test this hypothesis. We assessed 105 outpatients, diagnosed with bipolar disorder type I (BP-I) or bipolar disorder type II (BP-II) according to DSM-IV-TR criteria, and 113 HC subjects. History of childhood trauma was obtained using the Childhood Trauma Questionnaire (CTQ). High-resolution magnetic resonance imaging was performed on all subjects and volumes of the amygdala, hippocampus, nucleus accumbens, caudate, pallidum, putamen, and thalamus were measured using FreeSurfer. Patients with BP showed a global reduction of deep gray matter volumes compared to HCs. However, childhood trauma modulated the impact of the diagnosis specifically on the amygdala and hippocampus. Childhood trauma was associated with bilateral decreased volumes in HCs and increased volumes in patients with BP. The results suggest that childhood trauma may have a different effect in health and disease on volumes of gray matter in the amygdala and hippocampus, which are brain areas specifically involved in response to stress and emotion processing. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Thorium(IV) and zirconium(IV) complexes of oxygen donor ligands. Pt. 12

International Nuclear Information System (INIS)

Agarwal, R.K.; Jain, P.C.; Kapur, V.; Sharma, S.; Srivastava, A.K.

1980-01-01

Crystalline thorium (IV) chelates with mono N-oxides of 2,2'-bipyridine (bipyNO) and 1,10-phenanthroline (phenNO), ThX 4 x 2L(X = Cl,Br,NO 3 or NCS) and ThX 4 x 3L(X = I or ClO 4 and L = bipyNO or phenNO) have been synthesised and characterized on the basis of i.r. spectra, molar conductance, molecular weights, t.g.a. and d.t.a. data. All the complexes are weakly diamagnetic and contain bipyNO and phenNO bonded to thorium(IV) through nitrogen and oxygen. The coordination number of thorium(IV) varies from six to twelve depending on the nature of the anions. (orig.) [de

Solubility of Tc(IV) oxides

International Nuclear Information System (INIS)

Liu, D.J.; Fan, X.H.

2005-01-01

Full text of publication follows: The deep geological disposal of the high level radioactive wastes is expected to be a safer disposal method in most countries. The long-lived fission product 99 Tc is present in large quantities in nuclear wastes and its chemical behavior in aqueous solution is of considerable interest. Under the reducing conditions, expected to exist in a deep geological repository, it is generally predicted that technetium will be present as TcO 2 .nH 2 O. The solubility of Tc(IV) is used as a source term in performance assessment of radioactive waste repository. Technetium oxide was prepared by reduction of a technetate solution with Sn 2+ . The solubility of Tc(IV) oxide has been determined in simulated groundwater and re-distilled water under aerobic and anaerobic conditions. The effects of pH and CO 3 2- concentration of solution on solubility of Tc(IV) oxide were studied. The concentration of total technetium and Tc(IV) species in the solutions were periodically determined by separating the oxidized and reduced technetium species using a solvent extraction procedure and counting the beta activity of the 99 Tc with a liquid scintillation counter. The experimental results show that the rate of oxidation of Tc(IV) in simulated groundwater and re-distilled water is about (1.49∼1.86) x 10 -9 mol/(L.d) under aerobic conditions, but Tc(IV) in simulated groundwater and re-distilled water is not oxidized under anaerobic conditions. Under aerobic or anaerobic conditions the solubility of Tc(IV) oxide in simulated groundwater and re-distilled water is equal on the whole after centrifugation or ultrafiltration. The solubility of Tc(IV) oxide decreases with the increase of pH at pH 10 and is pH independent in the range 2 -8 to 10 -9 mol/L at 2 3 2- concentration. These data could be used to estimate the Tc(IV) solubility for cases where solubility limits transport of technetium in reducing environments of high-level waste repositories. (authors)

Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV.

Science.gov (United States)

Xiao, Yucheng; Jackson, James O; Liang, Songping; Cummins, Theodore R

2011-08-05

The voltage sensors of domains II and IV of sodium channels are important determinants of activation and inactivation, respectively. Animal toxins that alter electrophysiological excitability of muscles and neurons often modify sodium channel activation by selectively interacting with domain II and inactivation by selectively interacting with domain IV. This suggests that there may be substantial differences between the toxin-binding sites in these two important domains. Here we explore the ability of the tarantula huwentoxin-IV (HWTX-IV) to inhibit the activity of the domain II and IV voltage sensors. HWTX-IV is specific for domain II, and we identify five residues in the S1-S2 (Glu-753) and S3-S4 (Glu-811, Leu-814, Asp-816, and Glu-818) regions of domain II that are crucial for inhibition of activation by HWTX-IV. These data indicate that a single residue in the S3-S4 linker (Glu-818 in hNav1.7) is crucial for allowing HWTX-IV to interact with the other key residues and trap the voltage sensor in the closed configuration. Mutagenesis analysis indicates that the five corresponding residues in domain IV are all critical for endowing HWTX-IV with the ability to inhibit fast inactivation. Our data suggest that the toxin-binding motif in domain II is conserved in domain IV. Increasing our understanding of the molecular determinants of toxin interactions with voltage-gated sodium channels may permit development of enhanced isoform-specific voltage-gating modifiers.

The Impact of Local and Regional Disease Extent on Overall Survival in Patients With Advanced Stage IIIB/IV Non-Small Cell Lung Carcinoma

International Nuclear Information System (INIS)

Higginson, Daniel S.; Chen, Ronald C.; Tracton, Gregg; Morris, David E.; Halle, Jan; Rosenman, Julian G.; Stefanescu, Mihaela; Pham, Erica; Socinski, Mark A.; Marks, Lawrence B.

2012-01-01

Purpose: Patients with advanced stage IIIB or stage IV non-small cell lung carcinoma are typically treated with initial platinum-based chemotherapy. A variety of factors (eg, performance status, gender, age, histology, weight loss, and smoking history) are generally accepted as predictors of overall survival. Because uncontrolled pulmonary disease constitutes a major cause of death in these patients, we hypothesized that clinical and radiographic factors related to intrathoracic disease at diagnosis may be prognostically significant in addition to conventional factors. The results have implications regarding the selection of patients for whom palliative thoracic radiation therapy may be of most benefit. Methods and Materials: We conducted a pooled analysis of 189 patients enrolled at a single institution into 9 prospective phase II and III clinical trials involving first-line, platinum-based chemotherapy. Baseline clinical and radiographic characteristics before trial enrollment were analyzed as possible predictors for subsequent overall survival. To assess the relationship between anatomic location and volume of disease within the thorax and its effect on survival, the pre-enrollment computed tomography images were also analyzed by contouring central and peripheral intrapulmonary disease. Results: On univariate survival analysis, multiple pulmonary-related factors were significantly associated with worse overall survival, including pulmonary symptoms at presentation (P=.0046), total volume of intrathoracic disease (P=.0006), and evidence of obstruction of major bronchi or vessels on prechemotherapy computed tomography (P<.0001). When partitioned into central and peripheral volumes, central (P<.0001) but not peripheral (P=.74) disease was associated with worse survival. On multivariate analysis with known factors, pulmonary symptoms (hazard ratio, 1.46; P=.042), central disease volume (hazard ratio, 1.47; P=.042), and bronchial/vascular compression (hazard ratio, 1

Inventory of Federal energy-related environment and safety research for FY 1977. Volume IV. Indices

Energy Technology Data Exchange (ETDEWEB)

1978-07-01

This volume contains indexes useful for accessing projects contained in the FY 1977 Federal Inventory. The indexing has been greatly broadened this year to provide hard copy users with greater flexibility in locating projects. The Inventory projects are printed sequentially by log number. An inventory log number is a unique number assigned to each project from a block of numbers set aside for each agency. The association of agencies with blocks of log numbers is found in the table of contents of the Index (Volume III).

Characterizing functional lung heterogeneity in COPD using reference equations for CT scan-measured lobar volumes.

Science.gov (United States)

Come, Carolyn E; Diaz, Alejandro A; Curran-Everett, Douglas; Muralidhar, Nivedita; Hersh, Craig P; Zach, Jordan A; Schroeder, Joyce; Lynch, David A; Celli, Bartolome; Washko, George R

2013-06-01

CT scanning is increasingly used to characterize COPD. Although it is possible to obtain CT scan-measured lung lobe volumes, normal ranges remain unknown. Using COPDGene data, we developed reference equations for lobar volumes at maximal inflation (total lung capacity [TLC]) and relaxed exhalation (approximating functional residual capacity [FRC]). Linear regression was used to develop race-specific (non-Hispanic white [NHW], African American) reference equations for lobar volumes. Covariates included height and sex. Models were developed in a derivation cohort of 469 subjects with normal pulmonary function and validated in 546 similar subjects. These cohorts were combined to produce final prediction equations, which were applied to 2,191 subjects with old GOLD (Global Initiative for Chronic Obstructive Lung Disease) stage II to IV COPD. In the derivation cohort, women had smaller lobar volumes than men. Height positively correlated with lobar volumes. Adjusting for height, NHWs had larger total lung and lobar volumes at TLC than African Americans; at FRC, NHWs only had larger lower lobes. Age and weight had no effect on lobar volumes at TLC but had small effects at FRC. In subjects with COPD at TLC, upper lobes exceeded 100% of predicted values in GOLD II disease; lower lobes were only inflated to this degree in subjects with GOLD IV disease. At FRC, gas trapping was severe irrespective of disease severity and appeared uniform across the lobes. Reference equations for lobar volumes may be useful in assessing regional lung dysfunction and how it changes in response to pharmacologic therapies and surgical or endoscopic lung volume reduction.

Gulf of Mexico Sales 139 and 141: Central and western planning areas. Final environmental impact statement. Volume 2: Sections 4.D. through 9. Final report

International Nuclear Information System (INIS)

1991-10-01

The report is Volume II of two volumes. The EIS is a description of the environmental aspects and impacts of oil and gas activities resulting from these lease sales or the States bordering the Gulf of Mexico. The volume continues with Environmental Consequences; Consultation and Coordination; Bibliography and Special References; Preparers; Glossary; and the Appendices

On the stabilization of niobium(V) solutions by zirconium(IV) and hafnium(IV)

DEFF Research Database (Denmark)

Sørensen, E.; Bjerre, A.B.

1992-01-01

Niobium cannot be separated from zirconium or hafnium when these elements occur together in solution with common anions such as chloride and sulphate. This is ascribed to the co-polymerization of niobium(V) and the hydrolysed ionic species of zirconium(IV) and hafnium(IV) to form colloidal...

Analisis Cost-Volume-Profit Kaitannya dengan Perencanaan Laba

Directory of Open Access Journals (Sweden)

Rian Andriani

2018-01-01

Full Text Available Tujuan penelitian  ini adalah untuk menganalisis cost, volume, profit Break Event Point dan Margin Of Safety L.A English Course Baleendah Bandung pada kuartal I – IV. Metode penelitian yang digunakan adalah metode penelitian kuntitatif deskriptif. Teknik pengumpulan data menggunakan studi pustaka, observasi, wawancara, dan dokumentasi yang memiliki hubungan dengan pokok permasalahan. Teknik analisis data yang digunakan metode regresi kuadrat terkecil, break event point dan margin of safety.  Hasil menunjukan, biaya tertinggi terdapat pada kuartal I, volume penjualan  tertinggi terdapat pada kuartal I, laba tertinggi terdapat pada kuartal I, Break Event Point tertinggi terdapat pada kuartal I. Sedangkan Margin of safety (% tertinggi pada kuartal IV yaitu 91.9%. Masalah yang timbul dalam  perencanaan  laba yaitu pertama  pendapatan L.A English Course  naik turun  dalam satu  tahunnya, kedua  kurangnya promosi untuk beberapa program kecuali program regular. Upaya dalam mengatasi masalah yang timbul di L.A English Course yaitu pertama memberikan gratis biaya daftar, dan memberi voucher untuk siswa L.A yang memasukan siswa baru., kedua membagikan brosur, dan menawarkan program L.A. dengan melakukan follow up semua nomor telepon tamu yang pernah berkunjung.

Particulate emissions from new heavy duty vehicles (Euro IV and V); Partikeludslip fra nye tunge koeretoejer (Euronorm IV og V)

Energy Technology Data Exchange (ETDEWEB)

Jordal-Joergensen, J.; Ohm, A.; Willumsen, E. (COWI A/S, Kgs. Lyngby (DK))

2008-07-01

The new Danish act on environmental zones allows local authorities to define zones where EURO III or older heavy duty vehicles should be equipped with a particulate filter. The introduction of EURO IV and V has reduced particulate emissions from heavy duty vehicles by approximately 80 % based on the mass of particles. There is, however, substantial uncertainty about the impact on the number of ultrafine particles, since they are not covered by Euronorm standards. When passing the bill, the Danish Minister for the Environment of the time stated that all relevant knowledge about particle emission from heavy duty vehicles needed to be collected for subsequent publication. To this end, the Danish Environmental Protection Agency (DEPA) commissioned a literature survey. The purpose of the survey is to provide an overview of the latest knowledge in the field of particle emissions from heavy duty vehicles, with special focus on the average size of the particle emissions. Another objective of the study is to analyse the direct emissions of NO{sub 2} from heavy duty vehicles classified under EURO IV and V. (au)

Impact of partial-volume correction in oncological PET studies. A systematic review and meta-analysis

Energy Technology Data Exchange (ETDEWEB)

Cysouw, Matthijs C.F.; Kramer, Gerbrand M.; Hoekstra, Otto S. [VU University Medical Centre, Department of Radiology and Nuclear Medicine, Amsterdam (Netherlands); Schoonmade, Linda J. [VU University Medical Centre, Department of Medical Library, Amsterdam (Netherlands); Boellaard, Ronald [VU University Medical Centre, Department of Radiology and Nuclear Medicine, Amsterdam (Netherlands); University Medical Centre Groningen, Department of Nuclear Medicine and Molecular Imaging, Groningen (Netherlands); Vet, Henrica C.W. de [VU University Medical Centre, Department of Epidemiology and Biostatistics, Amsterdam (Netherlands)

2017-11-15

Positron-emission tomography can be useful in oncology for diagnosis, (re)staging, determining prognosis, and response assessment. However, partial-volume effects hamper accurate quantification of lesions <2-3 x the PET system's spatial resolution, and the clinical impact of this is not evident. This systematic review provides an up-to-date overview of studies investigating the impact of partial-volume correction (PVC) in oncological PET studies. We searched in PubMed and Embase databases according to the PRISMA statement, including studies from inception till May 9, 2016. Two reviewers independently screened all abstracts and eligible full-text articles and performed quality assessment according to QUADAS-2 and QUIPS criteria. For a set of similar diagnostic studies, we statistically pooled the results using bivariate meta-regression. Thirty-one studies were eligible for inclusion. Overall, study quality was good. For diagnosis and nodal staging, PVC yielded a strong trend of increased sensitivity at expense of specificity. Meta-analysis of six studies investigating diagnosis of pulmonary nodules (679 lesions) showed no significant change in diagnostic accuracy after PVC (p = 0.222). Prognostication was not improved for non-small cell lung cancer and esophageal cancer, whereas it did improve for head and neck cancer. Response assessment was not improved by PVC for (locally advanced) breast cancer or rectal cancer, and it worsened in metastatic colorectal cancer. The accumulated evidence to date does not support routine application of PVC in standard clinical PET practice. Consensus on the preferred PVC methodology in oncological PET should be reached. Partial-volume-corrected data should be used as adjuncts to, but not yet replacement for, uncorrected data. (orig.)

Neptunium (IV) oxalate solubility

International Nuclear Information System (INIS)

Luerkens, D.W.

1983-07-01

The equilibrium solubility of neptunium (IV) oxalate in nitric/oxalic acid solutions was determined at 22 0 C, 45 0 C, and 60 0 C. The concentrations of nitric/oxalic acid solutions represented a wide range of free oxalate ion concentration. A mathematical solubility model was developed which is based on the formation of the known complexes of neptunium (IV) oxalate. the solubility model uses a simplified concentration parameter which is proportional to the free oxalate ion concentration. The solubility model can be used to estimate the equilibrium solubility of neptunium (IV) oxalate over a wide range of oxalic and nitric acid concentrations at each temperature

Reactivity of the uranium (U(IV)/U(VI)) and the plutonium (Pu(III)/Pu(IV)) in nitric aqueous solution under ultrasound

International Nuclear Information System (INIS)

Venault, L.

1998-01-01

To minimize the volumes of solid waste and industrial effluents generated at the end of cycle, particularly in the spent nuclear fuel reprocessing industry, research is currently under way on so-called innovative processes, designed to induce chemical reactions without adding reagent to the media. Among these processes, the use of ultrasound can prove advantageous, and the purpose of this study is to assess accurately the potential for its application. In the present context, this work shows that the transmission of an ultrasonic wave in aqueous nitric acid solution leads to: the accumulation of nitrous acid in solution, until a steady-sate concentration is reached; the removal of nitrogen monoxide and nitrogen dioxide in the gas stream. The initial kinetics of the formation of HNO 2 in solution was quantified as a function of the nitric acid concentration and the ultrasound intensity. It was also shown than an excess of nitrous acid in nitric solution decomposes under the effect of ultrasound. It is also possible to accumulate hydrogen peroxide in solution during the ultrasonic irradiation of aqueous nitric acid solutions in the presence of a chemical species N 2 H 5 + , NH 2 SO 3 H...) which reacts rapidly with HNO 2 , preventing the reduction of H 2 O 2 by HNO 2 . The mechanisms of HNO 2 formation and decomposition, and the mechanism of H 2 O 2 formation during the ultrasonic irradiation of aqueous nitric acid solutions, are presented. Control of H 2 O 2 or HNO 2 in a nitric acid medium under the effect of an ultrasonic wave can be exploited to control redox reactions of uranium and plutonium ions, particularly with respect to the oxidation of U and Pu (U(IV)→ U(IV) or Pu(III) → Pu(IV)) and the reduction of Pu (Pu(IV)→ Pu(III). The redox behavior of uranium and plutonium ions in aqueous nitric solution subject to an ultrasonic flux is interpreted in term of effects induced on the reaction medium, and reveals the potential for using ultrasound to cause

Toxicity and efficacy of re-irradiation of high-grade glioma in a phase I dose- and volume escalation trial

DEFF Research Database (Denmark)

Møller, Søren; Munck Af Rosenschöld, Per; Costa, Junia

2017-01-01

.1-3.5) and the median overall survival was 7.0 months (95%CI: 3.5-10.5). Early side effects were mild and included headache and fatigue. Seven patients were progression-free beyond 10 weeks and were evaluable for late toxicity. Among these patients, three (43%) suffered late adverse events which included radionecrosis......INTRODUCTION: The purpose of this study was to evaluate the safety and efficacy of PET and MRI guided re-irradiation of recurrent high-grade glioma (HGG) and to assess the impact of radiotherapy dose, fractionation and irradiated volume. MATERIAL AND METHODS: Patients with localized, recurrent HGG...... (grades III-IV) and no other treatment options were eligible for a prospective phase I trial. Gross tumor volumes for radiotherapy were defined using T1-contrast enhanced MRI and (18)F-fluoro-ethyl tyrosine PET. Radiotherapy was delivered using volumetric modulated arc therapy with a 2-mm margin. The dose...

Enhanced Design Alternative IV

International Nuclear Information System (INIS)

Kramer, N.E.

1999-01-01

This report evaluates Enhanced Design Alternative (EDA) IV as part of the second phase of the License Application Design Selection (LADS) effort. The EDA IV concept was compared to the VA reference design using criteria from the Design Input Request for LADS Phase II EDA Evaluations (CRWMS M and O 1999b) and (CRWMS M and O 1999f). Briefly, the EDA IV concept arranges the waste packages close together in an emplacement configuration known as line load. Continuous pre-closure ventilation keeps the waste packages from exceeding their 350 C cladding and 200 C (4.3.6) drift wall temperature limits. This EDA concept keeps relatively high, uniform emplacement drift temperatures (post-closure) to drive water away from the repository and thus dry out the pillars between emplacement drifts. The waste package is shielded to permit human access to emplacement drifts and includes an integral filler inside the package to reduce the amount of water that can contact the waste form. Closure of the repository is desired 50 years after first waste is emplaced. Both backfill and drip shields will be emplaced at closure to improve post-closure performance. The EDA IV concept includes more defense-in-depth layers than the VA reference design because of its backfill, drip shield, waste package shielding, and integral filler features. These features contribute to the low dose-rate to the public achieved during the first 10,000 years of repository life as shown in Figure 3. Investigation of the EDA IV concept has led to the following general conclusions: (1) The total life cycle cost for EDA IV is about $21.7 billion which equates to a $11.3 billion net present value (both figures rounded up). (2) The incidence of design basis events for EDA IV is similar to the VA reference design. (3) The emplacement of the waste packages in drifts will be similar to the VA reference design. However, heavier equipment may be required because the shielded waste package will be heavier. (4) The heavier

Title IV compliance strategies and the incidence of co-pollutants and synergistic pollution controls

International Nuclear Information System (INIS)

South, D.W.; Bailey, K.A.

1993-01-01

Title 4 of the Clean Air Act Amendments (CAAA) of 1990 (Pub.L. 101-549) authorizes a system of tradeable SO 2 allowances in order to reduce Utility SO 2 emissions in a cost-effective manner. The CAAA also expanded and strengthened regulation of urban ozone nonattainment (Title 1), air toxics (Title 3) and utility NO x emissions (Title 4). Implementation of the requirements of each of these titles will force the utility industry to incur additional control expenditures. Utilities also face the potential for regulation of CO 2 emissions within the next decade, and increased regulation and reclassification of high volume combustion wastes, i.e., scrubber sludge, fly ash and bottom ash. Unfortunately for the utility industry, many of the issues in Titles 1, 3, 4 and other regulations have not been resolved, even though utility Phase 1 compliance planning has begun. This paper will examine compliance conflicts and synergies resulting from utility compliance with Title IV SO 2 requirements. The fundamental question addressed is: what multi-media effects are introduced and what opportunities exist through utility compliance with Title 4-SO 2 . Several issues will be addressed including: (1) the potential impact of non-SO 2 regulation on utility compliance and compliance costs, (2) the flexibility of utility SO 2 compliance options, (3) the synergies and co-pollutant effects associated with particular compliance options, (4) the impact of the timing and uncertainty of the various rules on utility compliance choice

40 CFR 86.1838-01 - Small volume manufacturer certification procedures.

Science.gov (United States)

2010-07-01

...-Duty Vehicles, Light-Duty Trucks, and Complete Otto-Cycle Heavy-Duty Vehicles § 86.1838-01 Small volume... companies; (iv) Vehicles and/or engines imported or distributed by all firms where the vehicles and/or...-use verification testing to have a minimum odometer mileage of 75 percent of the full useful life...

Soil Characterization at the Linde FUSRAP Site and the Impact on Soil Volume Estimates

International Nuclear Information System (INIS)

Boyle, J.; Kenna, T.; Pilon, R.

2002-01-01

The former Linde site in Tonawanda, New York is currently undergoing active remediation of Manhattan Engineering District's radiological contamination. This remediation is authorized under the Formerly Utilized Sites Remedial Action Program (FUSRAP). The focus of this paper will be to describe the impact of soil characterization efforts as they relate to soil volume estimates and project cost estimates. An additional objective is to stimulate discussion about other characterization and modeling technologies, and to provide a ''Lessons Learned'' scenario to assist in future volume estimating at other FUSRAP sites. Initial soil characterization efforts at the Linde FUSRAP site in areas known to be contaminated or suspected to be contaminated were presented in the Remedial Investigation Report for the Tonawanda Site, dated February 1993. Results of those initial characterization efforts were the basis for soil volume estimates that were used to estimate and negotiate the current remediation contract. During the course of remediation, previously unidentified areas of contamination were discovered, and additional characterization was initiated. Additional test pit and geoprobe samples were obtained at over 500 locations, bringing the total to over 800 sample locations at the 135-acre site. New data continues to be collected on a routine basis during ongoing remedial actions

Environmental Effects of Marine Energy Development Around the World. Annex IV Final Report

Energy Technology Data Exchange (ETDEWEB)

Copping, Andrea [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hanna, L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Whiting, J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Geerlofs, S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Grear, M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Blake, K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Coffey, A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Massaua, M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Brown-Saracino, J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Battey, H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2013-01-01

This Annex IV report contains three case studies of specific interactions of marine energy devices with the marine environment addressing the physical interactions between animals and tidal turbines, the acoustic impact of marine energy devices on marine animals, and the effects of energy removal on physical systems.

Synthesis and characterization of thorium(IV) and uranium(IV) complexes with Schiff bases

Energy Technology Data Exchange (ETDEWEB)

Radoske, Thomas; Maerz, Juliane; Kaden, Peter; Patzschke, Michael; Ikeda-Ohno, Atsushi [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Chemistry of the F-Elements

2017-06-01

We report herein the synthesis and characterization of several imine complexes of tetravalent thorium (Th(IV)) and uranium (U(IV)). The ligands investigated in this study are a Schiff base type, including the well-known salen ligand (H{sub 2}Le, Fig. 1). The complexation in solution was investigated by NMR measurements indicating paramagnetic effects of unpaired f-electrons of U(IV) on the ligand molecule. We also determined the solid-state molecular structures of the synthesized complexes by single crystal X-ray diffraction. The synthesized complexes show an eight-fold coordination geometry around the actinide center surrounded by two tetradentate ligands with 2N- and 2O-donor atoms.

The absence of protective effect of candesartan and angiotensin IV in the moderate brain injury in rats

International Nuclear Information System (INIS)

Nasser, M.; Botelle, L.; Javellaud, J.; Oudart, N.; Achard, J-M

2012-01-01

Background: angiotensin receptor blockers (ARB) are protective in various models of experimental ischemic stroke. This protective effect is mediated by the stimulation of non-AT1 receptors by angiotensin II and angiotensin IV. Since traumatic brain injury shares with ischemic cerebral injury several common mechanisms, we examined if a pretreatment with the ARB candesartan, or a post-treatment with angiotensin IV are also protective in a rat model of blunt traumatic brain injury (TBI). Methods :adults Sprague Dawley rats were treated for five days with candesartan (0.5 mg/kg/day) or saline by gavage prior to the induction of diffuse moderate TBI using the impact-acceleration model. Two others groups of rats were treated by a daily intraperitoneal injection of angiotensin IV (1.5 mg/kg/day) or saline for five days following TBI. Overall neurological insult were assessed daily by measuring the neurological score. Sensitive deficits (scotch test) and sensorimotor deficits (beam-walking test) were evaluated daily from day 1 to 7 and at day 15; cognitive impairment (object recognition test) was evaluated at day 15. Results : TBI induced significant sensitive and sensorimotor deficits that were maximal at day 1 and spontaneously improved with time. At day 15, traumatised animals had a marked alteration of the working memory. Neither treatment with candesartan, angiotensin IV or with erythropoietin decreased the severity of the initial sensorimotor deficits, nor accelerate the recovery rate. Candesartan, angiotensin IV had likewise no protective effect on the cognitive deficit evaluated to day 15. Conclusion: pretreatment with candesartan and post-treatment with angiotensin IV are both ineffective to protect against sensorimotor and c ognitive impairment in a rat model of impact-acceleration TBI. (author)

Articular congruity is associated with short-term clinical outcomes of operatively treated SER IV ankle fractures.

Science.gov (United States)

Berkes, Marschall B; Little, Milton T M; Lazaro, Lionel E; Pardee, Nadine C; Schottel, Patrick C; Helfet, David L; Lorich, Dean G

2013-10-02

With regard to supination-external rotation type-IV (SER IV) ankle fractures, there is no consensus regarding which patient, injury, and treatment variables most strongly influence clinical outcome. The purpose of this investigation was to examine the impact of articular surface congruity on the functional outcomes of operatively treatment of SER IV ankle fractures. A prospectively generated database consisting of operatively treated SER IV ankle fractures was reviewed. Postoperative computed tomography (CT) scans were used to assess ankle joint congruity. Ankles were considered incongruent in the presence of >2 mm of articular step-off, intra-articular loose bodies, or an articular surface gap of >2 mm (despite an otherwise anatomic reduction) due to joint impaction and comminution. Patients with at least one year of clinical follow-up were eligible for analysis. The primary and secondary outcome measures were the Foot and Ankle Outcome Score (FAOS) and ankle motion. One hundred and eight SER IV fractures met our inclusion criteria. The average duration of follow-up was twenty-one months. Seventy-two patients (67%) had a congruent ankle joint, and thirty-six (33%) had elements of articular surface incongruity on postoperative CT scanning. These two groups were similar with regard to comorbidities and injury and treatment variables. At the time of the final follow-up, the group with articular incongruity had a significantly worse FAOS with regard to symptoms (p = 0.012), pain (p = 0.004), and activities of daily living (p = 0.038). Those with articular incongruity had worse average scores in the FAOS sport domain as well. No significant differences in ankle motion were found between the two groups. In this population of patients with an operatively treated SER IV ankle fracture, the presence of postoperative articular incongruity correlated with inferior early clinical outcomes. Orthopaedic surgeons should scrutinize ankle fracture reductions and strive for

The Impact of Pretreatment Prostate Volume on Severe Acute Genitourinary Toxicity in Prostate Cancer Patients Treated With Intensity-Modulated Radiation Therapy

International Nuclear Information System (INIS)

Aizer, Ayal A.; Anderson, Nicole S.; Oh, Steven C.; Yu, James B.; McKeon, Anne M.; Decker, Roy H.; Peschel, Richard E.

2011-01-01

Purpose: To assess the impact of pretreatment prostate volume on the development of severe acute genitourinary toxicity in patients undergoing intensity-modulated radiation therapy (IMRT) for prostate cancer. Methods and Materials: Between 2004 and 2007, a consecutive sample of 214 patients who underwent IMRT (75.6 Gy) for prostate cancer at two referral centers was analyzed. Prostate volumes were obtained from computed tomography scans taken during treatment simulation. Genitourinary toxicity was defined using the National Cancer Institute Common Terminology Criteria for Adverse Events Version 3.0 guidelines. Acute toxicity was defined as any toxicity originating within 90 days of the completion of radiation therapy. Patients were characterized as having a small or large prostate depending on whether their prostate volume was less than or greater than 50 cm 3 , respectively. Genitourinary toxicity was compared in these groups using the chi-square or Fisher's exact test, as appropriate. Bivariate and multivariate logistic regression analysis was performed to further assess the impact of prostate volume on severe (Grade 3) acute genitourinary toxicity. Results: Patients with large prostates (>50 cm 3 ) had a higher rate of acute Grade 3 genitourinary toxicity (p = .02). Prostate volume was predictive of the likelihood of developing acute Grade 3 genitourinary toxicity on bivariate (p = .004) and multivariate (p = .006) logistic regression. Every 27.0 cm 3 increase in prostate volume doubled the likelihood of acute Grade 3 genitourinary toxicity. Conclusions: Patients with larger prostates are at higher risk for the development of severe acute genitourinary toxicity when treated with IMRT for prostate cancer.

Surplus plutonium disposition draft environmental impact statement. Volume 2

International Nuclear Information System (INIS)

1998-07-01

On May 22, 1997, DOE published a Notice of Intent (NOI) in the Federal Register (62 Federal Register 28009) announcing its decision to prepare an environmental impact statement (EIS) that would tier from the analysis and decisions reached in connection with the Storage and Disposition of Weapons-Usable Fissile Materials Final Programmatic EIS (Storage and Disposition PEIS). DOE's disposition strategy allows for both the immobilization of surplus plutonium and its use as mixed oxide (MOX) fuel in existing domestic, commercial reactors. The disposition of surplus plutonium would also involve disposal of the immobilized plutonium and MOX fuel (as spent nuclear fuel) in a geologic repository. The Surplus Plutonium Disposition Environmental Impact Statement analyzes alternatives that would use the immobilization approach (for some of the surplus plutonium) and the MOX fuel approach (for some of the surplus plutonium); alternatives that would immobilize all of the surplus plutonium; and the No Action Alternative. The alternatives include three disposition facilities that would be designed so that they could collectively accomplish disposition of up to 50 metric tons (55 tons) of surplus plutonium over their operating lives: (1) the pit disassembly and conversion facility would disassemble pits (a weapons component) and convert the recovered plutonium, as well as plutonium metal from other sources, into plutonium dioxide suitable for disposition; (2) the immobilization facility would include a collocated capability for converting nonpit plutonium materials into plutonium dioxide suitable for immobilization and would be located at either Hanford or SRS. DOE has identified SRS as the preferred site for an immobilization facility; (3) the MOX fuel fabrication facility would fabricate plutonium dioxide into MOX fuel. Volume 2 contains the appendices to the report and describe the following: Federal Register notices; contractor nondisclosure statement; adjunct melter

C,N-Chelated Organotin(IV) Azides: Synthesis, Structure and Use within the Click Chemistry.

Czech Academy of Sciences Publication Activity Database

Švec, P.; Bartoš, K.; Růžičková, Z.; Cuřínová, Petra; Dušek, L.; Turek, J.; de Proft, F.; Růžička, A.

2016-01-01

Roč. 40, č. 7 (2016), s. 5808-5817 ISSN 1144-0546 Grant - others:FWO(BE) 12T6615N Institutional support: RVO:67985858 Keywords : organotin(IV)azides * click chemistry * chelation Subject RIV: CC - Organic Chemistry Impact factor: 3.269, year: 2016

Phase Transitions in Layered Diguanidinium Hexachlorostannate(IV)

DEFF Research Database (Denmark)

Szafranski, Marek; Ståhl, Kenny

2016-01-01

is different. The transitions involve also transformations in the networks of N-H center dot center dot center dot Cl hydrogen bonds. The large volume (similar to 3%) and entropy (similar to R ln 3) change at the transition between phases II and III, and the giant pressure coefficient of -755 K GPa(-1......Five crystalline phases of diguanidinium hexachlorostannate(IV), [C(NH2)(3)](2)SnCl6, have been identified and characterized by calorimetric and dielectric measurements, single crystal X-ray diffraction at atmospheric and high pressure, and synchrotron X-ray powder diffraction. The crystal...... structures of all phases are built of similar layers in which the tin hexachloride anions are connected to the guanidinium cations by N-H center dot center dot center dot Cl hydrogen bonds, forming a interact primarily by Coulombic forces between the ions from ap. double H-bonded sheets. The layers, neutral...

Diversion Path Analysis handbook. Volume 4 (of 4 volumes). Computer Program 2

International Nuclear Information System (INIS)

Schleter, J.C.

1978-11-01

The FORTRAN IV computer program, DPA Computer Program 2 (DPACP-2) is used to produce tables and statistics on modifications identified when performing a Diversion Path Analysis (DPA) in accord with the methodology given in Volume 1. The program requires 259088 bytes exclusive of the operating system. The data assembled and tabulated by DPACP-2 assist the DPA team in analyzing and evaluating modifications to the plant's safeguards system that would eliminate, or reduce the severity of, vulnerabilities identified by means of the DPA. These vulnerabilities relate to the capability of the plant's material control and material accounting subsystems to indicate diversion of special nuclear material (SNM) by a knowledgeable insider

Reactivity of the uranium (U(IV)/U(VI)) and the plutonium (Pu(III)/Pu(IV)) in nitric aqueous solution under ultrasound; De l'influence des ultrasons sur la reactivite de l'uranium (U(IV)/U(VI)) et du plutonium (PU(III)/PU(IV)) en solution aqueuse nitrique

Energy Technology Data Exchange (ETDEWEB)

Venault, L

1998-07-01

To minimize the volumes of solid waste and industrial effluents generated at the end of cycle, particularly in the spent nuclear fuel reprocessing industry, research is currently under way on so-called innovative processes, designed to induce chemical reactions without adding reagent to the media. Among these processes, the use of ultrasound can prove advantageous, and the purpose of this study is to assess accurately the potential for its application. In the present context, this work shows that the transmission of an ultrasonic wave in aqueous nitric acid solution leads to: the accumulation of nitrous acid in solution, until a steady-sate concentration is reached; the removal of nitrogen monoxide and nitrogen dioxide in the gas stream. The initial kinetics of the formation of HNO{sub 2} in solution was quantified as a function of the nitric acid concentration and the ultrasound intensity. It was also shown than an excess of nitrous acid in nitric solution decomposes under the effect of ultrasound. It is also possible to accumulate hydrogen peroxide in solution during the ultrasonic irradiation of aqueous nitric acid solutions in the presence of a chemical species (N{sub 2}H{sub 5}{sup +}, NH{sub 2}SO{sub 3}H...) which reacts rapidly with HNO{sub 2}, preventing the reduction of H{sub 2}O{sub 2} by HNO{sub 2}. The mechanisms of HNO{sub 2} formation and decomposition, and the mechanism of H{sub 2}O{sub 2} formation during the ultrasonic irradiation of aqueous nitric acid solutions, are presented. Control of H{sub 2}O{sub 2} or HNO{sub 2} in a nitric acid medium under the effect of an ultrasonic wave can be exploited to control redox reactions of uranium and plutonium ions, particularly with respect to the oxidation of U and Pu (U(IV){yields} U(IV) or Pu(III) {yields} Pu(IV)) and the reduction of Pu (Pu(IV){yields} Pu(III). The redox behavior of uranium and plutonium ions in aqueous nitric solution subject to an ultrasonic flux is interpreted in term of effects

The kinetics of the cerium(IV)-uranium(IV) reaction at low sulfate concentrations

International Nuclear Information System (INIS)

Michaille, P.; Kikindai, T.

1977-01-01

The rate of oxidation of uranium(IV) by cerium(IV) was measured with a stopped-flow spectrophotometer at sulfuric acid concentrations of 2 x 10 -6 to 0.5 M. At a constant hydrogen ion concentration of 0.5 M, the maximum rate constant was observed for 2 x 10 -3 M sulfuric acid; at that concentration, two sulfate ions were involved in the activated complex. The dependence of the rate constant on the hydrogen ion concentration showed that the reaction paths involving one or two sulfate ions also involved one hydroxyl ion, whereas one hydrogen ion was involved in the five sulfate dependent path. Spectrophotometric measurements supported the existence of a hydrolyzed monosulfatocomplex of cerium(IV). (author)

Diorganotin(IV) Complexes with Methionine Methyl Ester. Equilibria ...

African Journals Online (AJOL)

IV) (DBT) and diphenyltin(IV) (DPT) was investigated at 25 °C and 0.1 mol dm–3 ionic strength in water for dimethyltin(IV) and in 50 % dioxane–water mixture for dibutyltin(IV) and diphenyltin(IV). Methionine methyl ester forms1:1 and 1:2 ...

Impact of deleting 5 DSM-IV personality disorders on prevalence, comorbidity, and the association between personality disorder pathology and psychosocial morbidity.

Science.gov (United States)

Zimmerman, Mark; Chelminski, Iwona; Young, Diane; Dalrymple, Kristy; Martinez, Jennifer

2012-02-01

A high rate of comorbidity among the personality disorders has been consistently identified as a problem. To address the problem of excessive comorbidity, the DSM-5 Personality and Personality Disorders Work Group recommended reducing the number of specific personality disorder diagnoses from 10 to 5 by eliminating paranoid, schizoid, histrionic, narcissistic, and dependent personality disorders. No study has examined the impact of this change. The present report from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project examined the impact of eliminating these 5 personality disorders on the prevalence of personality disorders in a large sample of psychiatric outpatients presenting for treatment, comorbidity among the personality disorders, and association with psychosocial morbidity. From September 1997 to June 2008, 2,150 psychiatric patients presenting to the Rhode Island Hospital outpatient practice were evaluated with semistructured diagnostic interviews for DSM-IV Axis I and Axis II disorders and measures of psychosocial morbidity. More than one-quarter of the patients were diagnosed with one of the 10 DSM-IV personality disorders (28.6%, n = 614). When 5 personality disorders were excluded from consideration, then 25.8% (n = 555) were diagnosed with at least 1 of the 5 personality disorders proposed for retention in DSM-5, and the comorbidity rate dropped from 29.8% to 21.3%. Compared to patients without a personality disorder, the patients with either a retained or an excluded personality disorder had greater psychosocial morbidity. There was little difference in psychosocial morbidity between patients with a retained and an excluded personality disorder. The Personality and Personality Disorders Work Group's desired goal of reducing comorbidity would be achieved by deleting 5 personality disorders, although comorbidity would not be eliminated. The reduction of comorbidity could come with a cost of false-negative diagnoses

Adsorption of Th(IV) and Pu(IV) on the surface of Pseudomonas fluorescens and Bacillus subtilis in the presence of desferrioxamine siderophore

International Nuclear Information System (INIS)

Yoshida, Takahiro; Ozaki, Takuo; Ohnuki, Toshihiko; Francis, Arokiasamy J.

2005-01-01

Adsorption of Th(IV) and Pu(IV) on a Gram-negative bacterium Pseudomonas fluorescens and a Gram-positive bacterium Bacillus subtilis in the presence of siderophore desferrioxamine B (DFO) was studied. Thorium(IV) and Pu(IV) were dissociated from DFO during adsorption on the cells. Thorium(IV) adsorption on bacterial cells in the presence of DFO was larger than that of Pu(IV) because of the smaller stability of the Th(IV)-DFO complex than that of the Pu(IV)-DFO complex. On the other hand, adsorption of Pu(IV) was larger than that of Fe(III), wherein the stability of the Pu(IV)- and Fe(III)-DFO complex is comparable. P. fluorescens showed a higher affinity for Th(IV) and Pu(IV) than B. subtilis, though potentiometric titration of bacterial cells indicated that surfaces of P. fluorescens and B. subtilis cells showed similar proton binding properties. (author)

A combined XAFS, ESI TOF-MS and LIBD study on the formation of polynuclear Zr(IV), Th(IV) and Pu(IV) species

Science.gov (United States)

Rothe, J.; Walther, C.; Brendebach, B.; Büchner, S.; Fuss, M.; Denecke, M. A.; Geckeis, H.

2009-11-01

The long term radiotoxicity of spent nuclear fuel disposed of in deep underground repositories after discharge from nuclear power reactors is determined by actinide elements, mainly plutonium. Water intrusion into the repository might cause container corrosion and leaching of the waste matrices, leading to the release of Pu and other actinides into the geological environment. Performance assessment for a future nuclear waste repository requires detailed knowledge on actinide aqueous chemistry in the aquifer surrounding the disposal site. Tetravalent actinides exhibit a strong tendency towards hydrolysis and subsequent polymerization and/or colloid formation. These species provide a potential pathway for migration of actinides away from the repository. Therefore, it is of fundamental interest to study their generation and properties in-situ. To this end, X-ray Absorption Fine Structure Spectroscopy (XAFS) at the INE-Beamline for actinide research at ANKA, Electrospray Mass-Spectrometry (ESI TOF-MS) and Laser Induced Breakdown Detection (LIBD) are combined at FZK-INE in a comprehensive attempt to characterize Zr(IV) (An(IV) analogue), Th(IV) and Pu(IV) polymerization and colloid formation.

Capability of differentiating smokers with normal pulmonary function from COPD patients: a comparison of CT pulmonary volume analysis and MR perfusion imaging

Energy Technology Data Exchange (ETDEWEB)

Fan, Li; Xia, Yi; Guan, Yu; Yu, Hong; Liu, Shi-yuan [Changzheng Hospital of the Second Military Medical University, Department of Radiology, Shanghai (China); Zhang, Tie-feng; Li, Bing [Changzheng Hospital of the Second Military Medical University, Department of Respiration Medicine, Shanghai (China)

2013-05-15

To compare CT volume analysis with MR perfusion imaging in differentiating smokers with normal pulmonary function (controls) from COPD patients. Sixty-two COPD patients and 17 controls were included. The total lung volume (TLV), total emphysema volume (TEV) and emphysema index (EI) were quantified by CT. MR perfusion evaluated positive enhancement integral (PEI), maximum slope of increase (MSI), maximum slope of decrease (MSD), signal enhancement ratio (SER) and signal intensity ratio (R{sub SI}) of perfusion defects to normal lung. There were 19 class I, 17 class II, 14 class III and 12 class IV COPD patients. No differences were observed in TLV, TEV and EI between control and class I COPD. The control was different from class II, III and IV COPD in TEV and EI. The control was different from each class of COPD in R{sub SI,} MSI, PEI and MSD. Differences were found in R{sub SI} between class I and III, I and IV, and II and IV COPD. Amongst controls, MR detected perfusion defects more frequently than CT detected emphysema. Compared with CT, MR perfusion imaging shows higher potential to distinguish controls from mild COPD and appears more sensitive in identifying abnormalities amongst smokers with normal pulmonary function (controls). (orig.)

Capability of differentiating smokers with normal pulmonary function from COPD patients: a comparison of CT pulmonary volume analysis and MR perfusion imaging

International Nuclear Information System (INIS)

Fan, Li; Xia, Yi; Guan, Yu; Yu, Hong; Liu, Shi-yuan; Zhang, Tie-feng; Li, Bing

2013-01-01

To compare CT volume analysis with MR perfusion imaging in differentiating smokers with normal pulmonary function (controls) from COPD patients. Sixty-two COPD patients and 17 controls were included. The total lung volume (TLV), total emphysema volume (TEV) and emphysema index (EI) were quantified by CT. MR perfusion evaluated positive enhancement integral (PEI), maximum slope of increase (MSI), maximum slope of decrease (MSD), signal enhancement ratio (SER) and signal intensity ratio (R SI ) of perfusion defects to normal lung. There were 19 class I, 17 class II, 14 class III and 12 class IV COPD patients. No differences were observed in TLV, TEV and EI between control and class I COPD. The control was different from class II, III and IV COPD in TEV and EI. The control was different from each class of COPD in R SI, MSI, PEI and MSD. Differences were found in R SI between class I and III, I and IV, and II and IV COPD. Amongst controls, MR detected perfusion defects more frequently than CT detected emphysema. Compared with CT, MR perfusion imaging shows higher potential to distinguish controls from mild COPD and appears more sensitive in identifying abnormalities amongst smokers with normal pulmonary function (controls). (orig.)

Comprehensive Cooling Water Study. Volume 1. Summary of environmental effects, Savannah River Plant. Annual report

International Nuclear Information System (INIS)

Gladden, J.B.; Lower, M.W.; Mackey, H.E.; Specht, W.L.; Wilde, E.W.

1985-07-01

This volume summarizes the technical content of Volumes II through XI of the annual report. Volume II provides a description of the SRP environment, facilities, and operation, and presents the objectives and design for the CCWS. Volume III presents information on water quality of SRP surface waters. Results of radionuclide and heavy metal transport studies are presented in Volume IV. Volume V contains findings from studies of wetland plant communities. Volume VI presents findings from studies of the lower food chain components of SRP aquatic habitats. The results of fisheries studies are reported in Volume VII. Studies of semi-aquatic vertebrate populations are reported in Volume VIII. Water-fowl utilization of SRP habitats is discussed in Volume IX. The status of endangered species that utilize SRP aquatic habitats is presented in Volume X. The findings from studies of Parr Pond ecosystem are presented in Volume XI

Generation IV national program

International Nuclear Information System (INIS)

Preville, M.; Sadhankar, R.; Brady, D.

2007-01-01

This paper outlines the Generation IV National Program. This program involves evolutionary and innovative design with significantly higher efficiencies (∼50% compared to present ∼30%) - sustainable, economical, safe, reliable and proliferation resistant - for future energy security. The Generation IV Forum (GIF) effectively leverages the resources of the participants to meet these goals. Ten countries signed the GIF Charter in 2001

Utilities and offsites design baseline. Outside Battery Limits Facility 6000 tpd SRC-I Demonstration Plant. Volume 1

Energy Technology Data Exchange (ETDEWEB)

None

1984-05-25

As part of the overall Solvent Refined Coal (SRC-1) project baseline being prepared by International Coal Refining Company (ICRC), the RUST Engineering Company is providing necessary input for the Outside Battery Limits (OSBL) Facilities. The project baseline is comprised of: design baseline - technical definition of work; schedule baseline - detailed and management level 1 schedules; and cost baseline - estimates and cost/manpower plan. The design baseline (technical definition) for the OSBL Facilities has been completed and is presented in Volumes I, II, III, IV, V and VI. The OSBL technical definition is based on, and compatible with, the ICRC defined statement of work, design basis memorandum, master project procedures, process and mechanical design criteria, and baseline guidance documents. The design basis memorandum is included in Paragraph 1.3 of Volume I. The baseline design data is presented in 6 volumes. Volume I contains the introduction section and utility systems data through steam and feedwater. Volume II continues with utility systems data through fuel system, and contains the interconnecting systems and utility system integration information. Volume III contains the offsites data through water and waste treatment. Volume IV continues with offsites data, including site development and buildings, and contains raw materials and product handling and storage information. Volume V contains wastewater treatment and solid wastes landfill systems developed by Catalytic, Inc. to supplement the information contained in Volume III. Volume VI contains proprietary information of Resources Conservation Company related to the evaporator/crystallizer system of the wastewater treatment area.

Final Environmental Impact Report/Environmental Impact Statement. Cullinan Ranch Specific Plan. Chapter 11. Appendix IV.

Science.gov (United States)

1984-05-01

growth toward lands already annexed and away from agricultural * lands until needed demands a sound basis upon which to render judgment. For the City...for Bureau of Land Management. Johnson, Patti 3. 1978 Patwin. In Handbook of North American Indians, Volume 8, California. Robert F. Heizer , ed

Impact of Case Volume on Outcomes of Ureteroscopy for Ureteral Stones

DEFF Research Database (Denmark)

Kandasami, Sangam V; Mamoulakis, Charalampos; El-Nahas, Ahmed R

2014-01-01

of case volume on the outcomes of URS for ureteral stones. DESIGN, SETTING, AND PARTICIPANTS: The URS Global Study collected prospective data on consecutive patients with urinary stones treated with URS at 114 centres worldwide for 1 yr. Centres were identified as low or high volume based on the median...... overall annual case volume. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Pre- and intraoperative characteristics, and postoperative outcomes in patients at low- and high-volume centres were compared. The relationships between case volume and stone-free rate (SFR), stone burden, complications...... SFR was 91.9% and 86.3% at high- and low-volume centres, respectively (pstone-free outcome increased with increasing case volume (p

Solubility studies of Np(IV)

International Nuclear Information System (INIS)

Zhang Yingjie; Yao Jun; Jiao Haiyang; Ren Lihong; Zhou Duo; Fan Xianhua

2001-01-01

The solubility of Np(IV) in simulated underground water and redistilled water has been measured with the variations of pH(6-12) and storage time (0-100 d) in the presence of reductant (Na 2 S 2 O 4 , metallic Fe). All experiments are performed in a low oxygen concentration glove box containing high purity Ar(99.99%), with an oxygen content of less than 5 x 10 -6 mol/mol. Experimental results show that the variation of pH in solution has little effect on the solubility of Np(IV) in the two kinds of water; the measured solubility of Np(IV) is affected by the composition of solution; with Na 2 S 2 O 4 as a reductant, the solubility of Np(IV) in simulated underground water is (9.23 +- 0.48) x 10 -10 mol/L, and that in redistilled water is (8.31 +- 0.35) x 10 -10 mol/L; with metallic Fe as a reductant, the solubility of Np(IV) in simulated underground water is (1.85 +- 0.56) x 10 -9 mol/L, and that in redistilled water is (1.48 +- 0.66) x 10 -9 mol/L

Qualifications manual for Inspection and Enforcement personnel. Volume I. Detailed data sheets

International Nuclear Information System (INIS)

Bartley, H.J.; Heyer, F.H.K.; Schwartz, E.G.; Harrison, O.J.; Krass, I.W.; Welsh, D.M.

1978-06-01

This document is the General Research Corporation (GRC) final report on Task I Job/Position Qualifications Statements for the Headquarters and regional position of NRC/IE. It reflects the results of upgrading, expanding, and reformating the preliminary Task I report. To accomplish this, GRC made a thorough examination of all data developed during Task I, Task II (Career Fields), Task III (Training Evaluation), and Task IV (Hiring Qualifications), to include NRC/IE comments and management decisions received. The reformated Job/Position Qualifications Statements resulting from this effort (Appendix A) identify three job qualifications categories for each position--performance, attributes, and knowledge. Two formats are provided: a summarized one for manpower management in Volume I and a detailed one for career and training management in Volume II. In addition to recommending approval of the job/position qualifications, GRC proposes their use in conjunction with the hiring qualifications in the Task IV report to update NRC/IE job descriptions

Alternatives for managing wastes from reactors and post-fission operations in the LWR fuel cycle. Volume 4. Alternatives for waste isolation and disposal

International Nuclear Information System (INIS)

1976-05-01

Volume IV of the five-volume report contains information on alternatives for final storage and disposal of radioactive wastes. Section titles include: basic concepts for geologic isolation; geologic storage alternatives; geologic disposal alternatives; extraterrestrial disposal; and, transmutation

Belgian Contribution to the IAEA CRP-IV Programme on Assuring Structural Integrity of Reactor Pressure Vessel

International Nuclear Information System (INIS)

Van Walle, E.; Chaouadi, R.; Scibetta, M.; Puzzolante, J.L.; Fabry, A.; Van de Velde, J.

1997-10-01

This report contains the actual status of the Belgian contribution to the IAEA CRP-IV program. Besides Charpy-V impact tests on as-received CRP-IV JRQ-specimens, fracture toughness tests were performed on two geometries: PCCV-specimens and CRB-specimens. The Charpy-V impact results correspond very well with the as-received CRP-III results. The fracture toughness data are also very consistent with identical tests recently performed on remaining as-received CRP-III material. Irradiated broken Charpy-V samples were reconstituted and tested in PCCV-mode. This was done in order to investigate the evolution of the ASME-curve versus the evolution of the mastercurve with irradiation. Initial results were reported. A new CHIVAS-irradiation in the CALLISTO-loop of the BR-2-reactor to support this investigation, is under preparation

Materials for generation-IV nuclear reactors

International Nuclear Information System (INIS)

Alvarez, M. G.

2009-01-01

Materials science and materials development are key issues for the implementation of innovative reactor systems such as those defined in the framework of the Generation IV. Six systems have been selected for Generation IV consideration: gas-cooled fast reactor, lead-cooled fast reactor, molten salt-cooled reactor, sodium-cooled fast reactor, supercritical water-cooled reactor, and very high temperature reactor. The structural materials need to resist much higher temperatures, higher neutron doses and extremely corrosive environment, which are beyond the experience of the current nuclear power plants. For this reason, the first consideration in the development of Generation-IV concepts is selection and deployment of materials that operate successfully in the aggressive operating environments expected in the Gen-IV concepts. This paper summarizes the Gen-IV operating environments and describes the various candidate materials under consideration for use in different structural applications. (author)

Adduct formation in Ce(IV) thenolytrifluoroacetonate

International Nuclear Information System (INIS)

Anufrieva, S.I.; Polyakova, G.V.; Snezhko, N.I.; Pechurova, N.I.; Martynenko, L.I.; Spitsyn, V.I.

1982-01-01

The literature contains no information on adduct formation in Ce(IV) β-diketonates with additional ligands. Since tetrakis-β-diketonates of Ce(IV) have four six-membered chelate rings, we can suppose that the introduction of an additional monodentate or bidentate ligand into the coordination sphere of Ce(IV) β-diketonates would lead to an increase in the coordination number (CN) of the Ce(IV) to nine or ten. The possibility of realization of such a high CN for Ce(IV) has not been proved; a study of adduct formation by Ce(IV) tetrakis-β-diketonates is thus of theoretical interest. Such an investigation might also be of practical interest, because the introduction of an additional ligand into the coordination sphere of a rare-earth β-diketonate usually increases the solubility of the β-diketonate in nonpolar solvents and increases the volatility of the compound; such a modification of the properties is important for various practical purposes. The aim of our work was to study the possibility of separating solid adducts of Ce(IV) tetrakis-thenoyltrifluoroacetonate with certain oxygen-containing and nitrogen-containing donor monodentate and bidentate ligands, and also to investigate their properties. As the β-diketone we used thenoyltrifluoroacetone (HTTFA), since in a parallel investigation it was found that Ce(TTFA) 4 has a high oxidation-reduction stability

Grade IV fibrosis interferes in biliary drainage after Kasai procedure.

Science.gov (United States)

Salzedas-Netto, A A; Chinen, E; de Oliveira, D F; Pasquetti, A F; Azevedo, R A; da Silva Patricio, F F; Cury, E K; Gonzalez, A M; Vicentine, F P P; Martins, J L

2014-01-01

Biliary atresia (BA) is the most common cause of liver transplantation in children. The earlier the treatment is done, the better the prognosis. The aim is to evaluate the impact of late diagnosis in children with BA, including the histopathological findings and success rate of biliary drainage in patients submitted to hepatic portoenterostomy (HPE). A retrospective study of cases of BA in the Department of Pediatric Surgery, Federal University of São Paulo (UNIFESP) between 1998-2011. We found 63 cases of BA; of these, 42 underwent HPE and 21 were referred for liver transplantation. Clinic and pathologic data were evaluated. The HPE was performed with a mean age of 86.5 days, with 16.6% having the operation at 60 days or earlier; 59.2% between 61 and 90 days; and 23.8% after 90 days. Successful biliary drainage occurred in 31% of surgeries, Mean days when HPE drained was 69.1 days, and 94.3 days when the surgery did not drain (P = .05). All patients who were successfully drained, did not have grade IV fibrosis on histology. In cases in which surgery was performed after 60 days that had not drained, 25% had grade IV fibrosis on biopsy (P = .0469). The age of HPE relates to better prognosis of the disease. It was found that the rate of grade IV fibrosis is higher in no drainage patients. All patients with grade IV fibrosis had no biliary drainage. Copyright © 2014 Elsevier Inc. All rights reserved.

Importance of timing of post-contrast MRI in rheumatoid arthritis: what happens during the first 60 minutes after IV gadolinium-DTPA?

DEFF Research Database (Denmark)

Østergaard, Mikkel; Klarlund, Mette

2001-01-01

compromises the differentiation of synovium from joint fluid. OBJECTIVE: To determine the time period after IV MRI contrast (gadolinium-DTPA (Gd)) injection in which synovial membrane volume determination is reliable. METHODS: MRI of five RA knees with clinical synovitis was carried out, with axial, T(1...... threshold. Thereafter, the measured volumes remained practically unchanged. CONCLUSION: This study suggests that MR image acquisition in arthritic knee joints should be performed within the initial approximately 10 minutes after gadolinium contrast injection to achieve the most accurate distinction between...

Genetics Home Reference: glycogen storage disease type IV

Science.gov (United States)

... Home Health Conditions Glycogen storage disease type IV Glycogen storage disease type IV Printable PDF Open All ... Javascript to view the expand/collapse boxes. Description Glycogen storage disease type IV (GSD IV) is an ...

Alternatives for managing wastes from reactors and post-fission operations in the LWR fuel cycle. Volume 4. Alternatives for waste isolation and disposal

Energy Technology Data Exchange (ETDEWEB)

1976-05-01

Volume IV of the five-volume report contains information on alternatives for final storage and disposal of radioactive wastes. Section titles include: basic concepts for geologic isolation; geologic storage alternatives; geologic disposal alternatives; extraterrestrial disposal; and, transmutation. (JGB)

Separation of uranium(V I) from binary solution mixtures with thorium(IV), zirconium(IV) and cerium(III) by foaming

International Nuclear Information System (INIS)

Shakir, K.; Aziz, M.; Benyamin, K.

1992-01-01

Foam separation has been investigated for the removal of uranium(V I), thorium(IV), zirconium(IV) and cerium(III) from dilute aqueous solutions at pH values ranging from about I to about II. Sodium laurel sulphate (Na L S) and acetyl trimethyl ammonium bromide (CTAB), being a strong anionic and a strong cationic surfactants, were used as collectors. The results indicate that Na L S can efficiently remove thorium(IV), zirconium(IV) and cerium(III) but not uranium(V I). CTAB, on the other hand, can successfully float only uranium(V I) and zirconium(IV). These differences in flotation properties of the different cations could be used to establish methods for the separation of uranium(V I) from binary mixtures with thorium(IV), zirconium(IV) or cerium(III). The results are discussed in terms of the hydrolytic behaviour of the tested cations and properties of used collectors.2 fig., 1 tab

IUE observations of interstellar Si IV and C IV lines observed in the spectra of Wolf-Rayet stars

International Nuclear Information System (INIS)

Smith, L.J.; Willis, A.J.; Wilson, R.

1980-01-01

Recent IUE observations of Wolf-Rayet stars show narrow absorption lines in the highly ionized species of Si IV and C IV. The strengths of these 'interstellar' Si IV and C IV lines observed in the spectra of 10 WR stars and two other early-type stars are compared. Of the WR sample, six stars exhibit very strong Si IV and C IV lines (Wsub(lambda) approximately 0.3 to 0.5 A) whilst the other four stars show much weaker lines (Wsub(lambda) approximately 0.1 A). There is no correlation between the strengths of these lines with either stellar distance or colour excess. The weaker absorptions may arise in the individual stellar H II regions, the observed strengths being consistent with those expected for stars with Tsub(eff) = 30 000 K. Five of the other stars which exhibit very strong absorptions lie in the line of sight to active interstellar regions (Cygnus and Carina nebulae) and it is considered probable that, in addition to their H II region components, the bulk of the strong Si IV and C IV absorptions originate in hot gas associated with these active regions. In the case of the WN5 star HD 50896 violet-displaced components are observed in the interstellar lines of low ionization species. These are thought to be produced in the ring nebula S308 surrounding HD 50896. (author)

Current status of NPP generation IV

International Nuclear Information System (INIS)

Yohanes Dwi Anggoro; Dharu Dewi; Nurlaila; Arief Tris Yuliyanto

2013-01-01

Today development of nuclear technology has reached the stage of research and development of Generation IV nuclear power plants (advanced reactor systems) which is an innovative development from the previous generation of nuclear power plants. There are six types of power generation IV reactors, namely: Very High Temperature Reactor (VHTR), Sodium-cooled Fast Reactor (SFR), Gas-cooled Fast Reactor (GFR), Lead-cooled Fast Reactor (LFR), Molten Salt Reactor (MSR), and Super Critical Water-cooled Reactor (SCWR). The purpose of this study is to know the development of Generation IV nuclear power plants that have been done by the thirteen countries that are members of the Gen IV International Forum (GIF). The method used is review study and refers to various studies related to the current status of research and development of generation IV nuclear power. The result of this study showed that the systems and technology on Generation IV nuclear power plants offer significant advances in sustainability, safety and reliability, economics, and proliferation resistance and physical protection. In addition, based on the research and development experience is estimated that: SFR can be used optimally in 2015, VHTR in 2020, while NPP types GFR, LFR, MSR, and SCWR in 2025. Utilization of NPP generation IV said to be optimal if fulfill the goal of NPP generation IV, such as: capable to generate energy sustainability and promote long-term availability of nuclear fuel, minimize nuclear waste and reduce the long term stewardship burden, has an advantage in the field of safety and reliability compared to the previous generation of NPP and VHTR technology have a good prospects in Indonesia. (author)

Impact of entrainment and impingement on fish populations in the Hudson River estuary. Volume I. Entrainment-impact estimates for six fish populations inhabiting the Hudson River estuary

International Nuclear Information System (INIS)

Boreman, J.; Barnthouse, L.W.; Vaughn, D.S.; Goodyear, C.P.; Christensen, S.W.; Kumar, K.D.; Kirk, B.L.; Van Winkle, W.

1982-01-01

This volume is concerned with the estimation of the direct (or annual) entrainment impact of power plants on populations of striped bass, white perch, Alosa spp. (blueback herring and alewife), American shad, Atlantic tomcod, and bay anchovy in the Hudson River estuary. Entrainment impact results from the killing of fish eggs, larvae, and young juveniles that are contained in the cooling water cycled through a power plant. An Empirical Transport Model (ETM) is presented as the means of estimating a conditional entrainment mortality rate (defined as the fraction of a year class which would be killed due to entrainment in the absence of any other source of mortality). Most of this volume is concerned with the estimation of several parameters required by the ETM: physical input parameters (e.g., power-plant withdrawal flow rates); the longitudinal distribution of ichthyoplankton in time and space; the duration of susceptibility of the vulnerable organisms; the W-factors, which express the ratios of densities of organisms in power plant intakes to densities of organisms in the river; and the entrainment mortality factors (f-factors), which express the probability that an organism will be killed if it is entrained. Once these values are obtained, the ETM is used to estimate entrainment impact for both historical and projected conditions

Application for approval of the Cold Lake Expansion Project: volume 2: environmental impact assessment: Part 1: biophysical and resource use assessment. Part 2: impact model descriptions

International Nuclear Information System (INIS)

Green, J.; Eccles, R.; Hegmann, G.; Morrison, L.; Salter, R.; van Egmond, T.; Vonk, P.; Ash, G.; Crowther, R.; Dance, T.; Edwards, W.; Veldman, W.

1997-02-01

An environmental assessment of the Cold Lake Expansion Project has been conducted to identify major issues of concern by public and government agencies, to determine means to eliminate or reduce those impacts, and to recommend any further efforts required to obtain missing information or monitor impacts. Volume 2 of the environmental impact assessment is divided into two parts. Part 1 (biophysical and resource use assessment) constitutes the primary environmental impact assessment document for the Cold Lake expansion project. It includes technical support documentation in regard to: (1) an assessment of noise impacts, (2) an assessment of greenhouse gas emissions, (3) a conceptual conservation and reclamation plan, (4) a historical resource impact assessment, and (5) a description of effects of oil spills on fish. Part 2 (impact model description) serves a reference document for part 1. It describes the approach taken in developing and assessing the impact models, discusses proposed methods for mitigation and management of residual impacts, and the recommended monitoring requirements for each of the major resource disciplines. The impact models describe the specific pathways through which impacts will occur as a result of interactions between project-related activities and important environmental components. 476 refs., 58 tabs., 23 figs

Exposure and materiality of the secondary room and its impact on the impulse response of coupled-volume concert halls

Science.gov (United States)

Ermann, Michael; Johnson, Marty

2005-06-01

How does sound decay when one room is partially exposed to another (acoustically coupled)? More specifically, this research aims to quantify how operational and design decisions impact sound fields in the design of concert halls with acoustical coupling. By adding a second room to a concert hall, and designing doors to control the sonic transparency between the two rooms, designers can create a new, coupled acoustic. Concert halls use coupling to achieve a variable, longer, and distinct reverberant quality for their musicians and listeners. For this study a coupled-volume shoebox concert hall is conceived with a fixed geometric volume, form, and primary-room sound absorption. Aperture size and secondary-room sound absorption levels are established as variables. Statistical analysis of sound decay in this simulated hall suggests a highly sensitive relationship between the double-sloped condition and (1) architectural composition, as defined by the aperture size exposing the chamber and (2) materiality, as defined by the sound absorptance in the coupled volume. The theoretical, mathematical predictions are compared with coupled-volume concert hall field measurements and guidelines are suggested for future designs of coupled-volume concert halls.

New method of assigning uncertainty in volume calibration

International Nuclear Information System (INIS)

Lechner, J.A.; Reeve, C.P.; Spiegelman, C.H.

1980-12-01

This paper presents a practical statistical overview of the pressure-volume calibration curve for large nuclear materials processing tanks. It explains the appropriateness of applying splines (piecewise polynomials) to this curve, and it presents an overview of the associated statistical uncertainties. In order to implement these procedures, a practical and portable FORTRAN IV program is provided along with its users' manual. Finally, the recommended procedure is demonstrated on actual tank data collected by NBS

Uranium milling: Draft generic environmental impact statement: Volume 2, Appendices

International Nuclear Information System (INIS)

1979-04-01

This volume contains appendices supporting the discussions in Volume 1. In some cases, the appendices expound upon arguments developed in the main document; in other cases, supplementary material considered to be relevant but not presented in Volume 1 is included. A third category encompasses reprinting of pertinent documents felt to be necessary for a comprehensive presentation of the current situation, e.g., Public Law 95-604

Collagen type IV at the fetal-maternal interface.

Science.gov (United States)

Oefner, C M; Sharkey, A; Gardner, L; Critchley, H; Oyen, M; Moffett, A

2015-01-01

Extracellular matrix proteins play a crucial role in influencing the invasion of trophoblast cells. However the role of collagens and collagen type IV (col-IV) in particular at the implantation site is not clear. Immunohistochemistry was used to determine the distribution of collagen types I, III, IV and VI in endometrium and decidua during the menstrual cycle and the first trimester of pregnancy. Expression of col-IV alpha chains during the reproductive cycle was determined by qPCR and protein localisation by immunohistochemistry. The structure of col-IV in placenta was examined using transmission electron microscopy. Finally, the expression of col-IV alpha chain NC1 domains and collagen receptors was localised by immunohistochemistry. Col-IV alpha chains were selectively up-regulated during the menstrual cycle and decidualisation. Primary extravillous trophoblast cells express collagen receptors and secrete col-IV in vitro and in vivo, resulting in the increased levels found in decidua basalis compared to decidua parietalis. A novel expression pattern of col-IV in the mesenchyme of placental villi, as a three-dimensional network, was found. NC1 domains of col-IV alpha chains are known to regulate tumour cell migration and the selective expression of these domains in decidua basalis compared to decidua parietalis was determined. Col-IV is expressed as novel forms in the placenta. These findings suggest that col-IV not only represents a structural protein providing tissue integrity but also influences the invasive behaviour of trophoblast cells at the implantation site. Copyright © 2014 Elsevier Ltd. All rights reserved.

ARPA-E Impacts: A Sampling of Project Outcomes, Volume II

Energy Technology Data Exchange (ETDEWEB)

Rohlfing, Eric [Dept. of Energy (DOE), Washington DC (United States). Advanced Research Projects Agency-Energy (ARPA-E)

2017-02-27

The Advanced Research Projects Agency-Energy (ARPA-E) is demonstrating that a collaborative model has the power to deliver real value. The Agency’s first compilation booklet of impact sheets, published in 2016, began to tell the story of how ARPA-E has already made an impact in just seven years—funding a diverse and sophisticated research portfolio on advanced energy technologies that enable the United States to tackle our most pressing energy challenges. One year later our research investments continue to pay off, with a number of current and alumni project teams successfully commercializing their technologies and advancing the state of the art in transformative areas of energy science and engineering. There is no single measure that can fully illustrate ARPA-E’s success to date, but several statistics viewed collectively begin to reveal the Agency’s impact. Since 2009, ARPA-E has provided more than $1.5 billion in funding for 36 focused programs and three open funding solicitations, totaling over 580 projects. Of those, 263 are now alumni projects. Many teams have successfully leveraged ARPA-E’s investment: 56 have formed new companies, 68 have partnered with other government agencies to continue their technology development, and 74 teams have together raised more than $1.8 billion in reported funding from the private sector to bring their technologies to market. However, even when viewed together, those measures do not capture ARPA-E’s full impact. To best understand the Agency’s success, the specific scientific and engineering challenges that ARPA-E project teams have overcome must be understood. This booklet provides concrete examples of those successes, ranging from innovations that will bear fruit in the future to ones that are beginning to penetrate the market as products today. Importantly, half of the projects highlighted in this volume stem from OPEN solicitations, which the agency has run in 2009, 2012, and 2015. ARPA-E’s OPEN programs

Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume 1. Program summary

Energy Technology Data Exchange (ETDEWEB)

1979-12-01

This report summarizes the Nonproliferation Alternative Systems Assessment Program (NASAP): its background, its studies, and its results. This introductory chapter traces the growth of the issue of nuclear weapons proliferation and the organization and objectives of NASAP. Chapter 2 summarizes the program's assessments, findings and recommendations. Each of Volumes II-VII reports on an individual assessment (Volume II: Proliferation Resistance; Volume III: Resources and Fuel Cycle Facilities; Volume IV: Commercial Potential; Volume V: Economics and Systems Analysis; Volume VI: Safety and Environmental Considerations for Licensing; Volume VII: International Perspectives). Volume VIII (Advanced Concepts) presents a combined assessment of several less fully developed concepts, and Volume IX (Reactor and Fuel Cycle Descriptions) provides detailed descriptions of the reactor and fuel-cycle systems studied by NASAP.

Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume 1. Program summary

International Nuclear Information System (INIS)

1979-12-01

This report summarizes the Nonproliferation Alternative Systems Assessment Program (NASAP): its background, its studies, and its results. This introductory chapter traces the growth of the issue of nuclear weapons proliferation and the organization and objectives of NASAP. Chapter 2 summarizes the program's assessments, findings and recommendations. Each of Volumes II-VII reports on an individual assessment (Volume II: Proliferation Resistance; Volume III: Resources and Fuel Cycle Facilities; Volume IV: Commercial Potential; Volume V: Economics and Systems Analysis; Volume VI: Safety and Environmental Considerations for Licensing; Volume VII: International Perspectives). Volume VIII (Advanced Concepts) presents a combined assessment of several less fully developed concepts, and Volume IX (Reactor and Fuel Cycle Descriptions) provides detailed descriptions of the reactor and fuel-cycle systems studied by NASAP

A Si IV/O IV Electron Density Diagnostic for the Analysis of IRIS Solar Spectra

Science.gov (United States)

Young, P. R.; Keenan, F. P.; Milligan, R. O.; Peter, H.

2018-04-01

Solar spectra of ultraviolet bursts and flare ribbons from the Interface Region Imaging Spectrograph (IRIS) have suggested high electron densities of > {10}12 cm‑3 at transition region temperatures of 0.1 MK, based on large intensity ratios of Si IV λ1402.77 to O IV λ1401.16. In this work, a rare observation of the weak O IV λ1343.51 line is reported from an X-class flare that peaked at 21:41 UT on 2014 October 24. This line is used to develop a theoretical prediction of the Si IV λ1402.77 to O IV λ1401.16 ratio as a function of density that is recommended to be used in the high-density regime. The method makes use of new pressure-dependent ionization fractions that take account of the suppression of dielectronic recombination at high densities. It is applied to two sequences of flare kernel observations from the October 24 flare. The first shows densities that vary between 3× {10}12 and 3× {10}13 cm‑3 over a seven-minute period, while the second location shows stable density values of around 2× {10}12 cm‑3 over a three-minute period.

Impact of endobronchial coiling on segmental bronchial lumen in treated and untreated lung lobes: Correlation with changes in lung volume, clinical and pulmonary function tests.

Science.gov (United States)

Kloth, C; Thaiss, W M; Hetzel, J; Ditt, H; Grosse, U; Nikolaou, K; Horger, M

2016-07-01

To assess the impact of endobronchial coiling on the segment bronchus cross-sectional area and volumes in patients with lung emphysema using quantitative chest-CT measurements. Thirty patients (female = 15; median age = 65.36 years) received chest-CT before and after endobronchial coiling for lung volume reduction (LVR) between January 2010 and December 2014. Thin-slice (0.6 mm) non-enhanced image data sets were acquired both at end-inspiration and end-expiration using helical technique and 120 kV/100-150 mAs. Clinical response was defined as an increase in the walking distance (Six-minute walk test; 6MWT) after LVR-therapy. Additionally, pulmonary function test (PFT) measurements were used for clinical correlation. In the treated segmental bronchia, the cross-sectional lumen area showed significant reduction (p  0.05). In the ipsilateral lobes, the lumina showed no significant changes. In the contralateral lung, we found tendency towards increased cross-sectional area in inspiration (p = 0.06). Volumes of the treated segments correlated with the treated segmental bronchial lumina in expiration (r = 0.80, p volume of the treated lobe in responders only. Endobronchial coiling causes significant decrease in the cross-sectional area of treated segment bronchi in inspiration and a slight increase in expiration accompanied by a volume reduction. • Endobronchial coiling has indirect impact on cross-sectional area of treated segment bronchi • Volume changes of treated lobes correlate with changes in bronchial cross-sectional area • Coil-induced effects reflect their stabilizing and stiffening impact on lung parenchyma • Endobronchial coiling reduces bronchial collapsing compensating the loss of elasticity.

Batch and column adsorption behaviors of Se(IV) and Te(IV) on organic and inorganic ion exchangers from HCl solutions

Energy Technology Data Exchange (ETDEWEB)

El-Sweify, Fatma H.; Abdel-Fattah, Alaa El-Din A.; Aly, Shorouk M.; Ghamry, Mohamed A. [Atomic Energy Authority, Cairo (Egypt). Hot Laboratories Center; El-Sheikh, Ragaa [Zagazig Univ. (Egypt). Chemistry Dept.

2017-07-01

Adsorption behaviors of Se(IV) and Te(IV) on the inorganic ion exchanger ceric tungstate (CeW) was studied under static and dynamic conditions and compared with the adsorption on the organic cation and anion exchangers Dowex-50X8 and AG-2X8, respectively. The radioactive isotopes {sup 75}Se and {sup 123m}Te were used to trace the respective elements. Some parameters affecting the adsorption were investigated under static conditions. In the case of batch technique the adsorption was studied from slightly acidic HCl as well as slightly alkaline media, i.e. at two pH-ranges. Se(IV) and Te(IV) were adsorbed on both the inorganic ion exchanger (CeW) and on AG-2X8, from slightly alkaline solutions. From the similarity of adsorption on both ion exchangers it was clear that (CeW) acts as an anion exchanger. Moreover, the obtained K{sub d}-values for the adsorption on (CeW) were much higher than those for the adsorption on the organic anion exchanger AG-2X8. Se(IV) was not adsorbed on Dowex-50X8 all over the studied pH-range whereas Te(IV) was slightly adsorbed. Loading and elution behaviors of Se(IV) and Te(IV) on columns of AG-2X8 and (CeW) were studied using solutions of HCl of different concentrations. Some good separation alternatives of Se(IV) and Te(IV) under certain conditions were achieved.

Predicting DPP-IV inhibitors with machine learning approaches

Science.gov (United States)

Cai, Jie; Li, Chanjuan; Liu, Zhihong; Du, Jiewen; Ye, Jiming; Gu, Qiong; Xu, Jun

2017-04-01

Dipeptidyl peptidase IV (DPP-IV) is a promising Type 2 diabetes mellitus (T2DM) drug target. DPP-IV inhibitors prolong the action of glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP), improve glucose homeostasis without weight gain, edema, and hypoglycemia. However, the marketed DPP-IV inhibitors have adverse effects such as nasopharyngitis, headache, nausea, hypersensitivity, skin reactions and pancreatitis. Therefore, it is still expected for novel DPP-IV inhibitors with minimal adverse effects. The scaffolds of existing DPP-IV inhibitors are structurally diversified. This makes it difficult to build virtual screening models based upon the known DPP-IV inhibitor libraries using conventional QSAR approaches. In this paper, we report a new strategy to predict DPP-IV inhibitors with machine learning approaches involving naïve Bayesian (NB) and recursive partitioning (RP) methods. We built 247 machine learning models based on 1307 known DPP-IV inhibitors with optimized molecular properties and topological fingerprints as descriptors. The overall predictive accuracies of the optimized models were greater than 80%. An external test set, composed of 65 recently reported compounds, was employed to validate the optimized models. The results demonstrated that both NB and RP models have a good predictive ability based on different combinations of descriptors. Twenty "good" and twenty "bad" structural fragments for DPP-IV inhibitors can also be derived from these models for inspiring the new DPP-IV inhibitor scaffold design.

Spectroscopy study of ceramic pigments based on Ce(IV)-Pr(IV) oxide

International Nuclear Information System (INIS)

Furtado, L.; Toma, H.E.

1991-01-01

The synthesis and spectroscopic properties of a series of cerium(IV)-praseodimium(IV) oxide pigments are reported. The pigments exhibit brick-red colours and are suitable for ceramic applications because of their high temperature stability. Electronic absorption spectra of the pigments suspended in a gel matrix of polyvinyl alcohol-sodium tetradecaborate mixture, consists of broad band with gaussian components at 372 and 472nm. These bands are described to charge -transfer transitions from the occupied oxygen p-orbitals to the empty f levels of the lanthanides. (author)

1L Mark-IV Target Design Review

Energy Technology Data Exchange (ETDEWEB)

Koehler, Paul E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-11-16

This presentation includes General Design Considerations; Current (Mark-III) Lower Tier; Mark-III Upper Tier; Performance Metrics; General Improvements for Material Science; General Improvements for Nuclear Science; Improving FOM for Nuclear Science; General Design Considerations Summary; Design Optimization Studies; Expected Mark-IV Performance: Material Science; Expected Mark-IV Performance: Nuclear Science (Disk); Mark IV Enables Much Wider Range of Nuclear-Science FOM Gains than Mark III; Mark-IV Performance Summary; Rod or Disk? Center or Real FOV?; and Project Cost and Schedule.

RELAP5/MOD3 code manual. Volume 4, Models and correlations

International Nuclear Information System (INIS)

1995-08-01

The RELAP5 code has been developed for best-estimate transient simulation of light water reactor coolant systems during postulated accidents. The code models the coupled behavior of the reactor coolant system and the core for loss-of-coolant accidents and operational transients such as anticipated transient without scram, loss of offsite power, loss of feedwater, and loss of flow. A generic modeling approach is used that permits simulating a variety of thermal hydraulic systems. Control system and secondary system components are included to permit modeling of plant controls, turbines, condensers, and secondary feedwater systems. RELAP5/MOD3 code documentation is divided into seven volumes: Volume I presents modeling theory and associated numerical schemes; Volume II details instructions for code application and input data preparation; Volume III presents the results of developmental assessment cases that demonstrate and verify the models used in the code; Volume IV discusses in detail RELAP5 models and correlations; Volume V presents guidelines that have evolved over the past several years through the use of the RELAP5 code; Volume VI discusses the numerical scheme used in RELAP5; and Volume VII presents a collection of independent assessment calculations

Impact of the smoking ban on the volume of bar sales in Ireland: evidence from time series analysis.

Science.gov (United States)

Cornelsen, Laura; Normand, Charles

2012-05-01

This paper is the first to estimate the economic impact of a comprehensive smoking ban in all enclosed public places of work, on bars in Ireland. The demand in bars, represented by a monthly index of sales volume, is explained by relative prices in bars, prices of alcohol sold in off-licences and the aggregate retail sales (ARS) as a proxy for general economic activity and incomes. The smoking ban is included into the model as a step dummy and the modelling is done using ARIMAX strategy. The results show a reduction in the volume of sales in bars by -4.6% (p<0.01) following the ban. Copyright © 2011 John Wiley & Sons, Ltd.

Investigating the reasons of variability in Si IV and C IV broad absorption line troughs of quasars

Science.gov (United States)

Stathopoulos, Dimitrios; Lyratzi, Evangelia; Danezis, Emmanuel; Antoniou, Antonios; Tzimeas, Dimitrios

2017-09-01

In this paper we analyze the C IV and Si IV broad absorption troughs of two BALQSOs (J101056.69+355833.3, J114548.38+393746.6) to the individual components they consist of. By analyzing a BAL trough to its components we have the advantage to study the variations of the individual absorbing systems in the line of sight and not just the variations of the whole absorption trough or the variations of selected portions of BAL troughs exhibiting changes. We find that the velocity shifts and FWHMs (Full Width at Half Maximum) of the individual components do not vary between an interval of six years. All variable components show changes in the optical depths at line centers which are manifested as variations in the EW (Equivalent Width) of the components. In both BALQSOs, over corresponding velocities, Si IV has higher incidence of variability than C IV. From our analysis, evidence is in favour of different covering fractions between C IV and Si IV. Finally, although most of our results favour the crossing cloud scenario as the cause of variability, there is also strong piece of evidence indicating changing ionization as the source of variability. Thus, a mixed situation where both physical mechanisms contribute to BAL variability is the most possible scenario.

Topological characterisation and identification of critical domains within glucosyltransferase IV (GtrIV of Shigella flexneri

Directory of Open Access Journals (Sweden)

Nair Anesh

2011-12-01

Full Text Available Abstract Background The three bacteriophage genes gtrA, gtrB and gtr(type are responsible for O-antigen glucosylation in Shigella flexneri. Both gtrA and gtrB have been demonstrated to be highly conserved and interchangeable among serotypes while gtr(type was found to be specific to each serotype, leading to the hypothesis that the Gtr(type proteins are responsible for attaching glucosyl groups to the O-antigen in a site- and serotype- specific manner. Based on the confirmed topologies of GtrI, GtrII and GtrV, such interaction and attachment of the glucosyl groups to the O-antigen has been postulated to occur in the periplasm. Results In this study, the topology of GtrIV was experimentally determined by creating different fusions between GtrIV and a dual-reporter protein, PhoA/LacZ. This study shows that GtrIV consists of 8 transmembrane helices, 2 large periplasmic loops, 2 small cytoplasmic N- and C- terminal ends and a re-entrant loop that occurs between transmembrane helices III and IV. Though this topology differs from that of GtrI, GtrII, GtrV and GtrX, it is very similar to that of GtrIc. Furthermore, both the N-terminal periplasmic and the C-terminal periplasmic loops are important for GtrIV function as shown via a series of loop deletion experiments and the creation of chimeric proteins between GtrIV and its closest structural homologue, GtrIc. Conclusion The current study provides the basis for elucidating the structure and mechanism of action of this important O-antigen modifying glucosyltransferase.

Greater-than-Class C low-level waste characterization. Appendix I: Impact of concentration averaging low-level radioactive waste volume projections

International Nuclear Information System (INIS)

Tuite, P.; Tuite, K.; O'Kelley, M.; Ely, P.

1991-08-01

This study provides a quantitative framework for bounding unpackaged greater-than-Class C low-level radioactive waste types as a function of concentration averaging. The study defines the three concentration averaging scenarios that lead to base, high, and low volumetric projections; identifies those waste types that could be greater-than-Class C under the high volume, or worst case, concentration averaging scenario; and quantifies the impact of these scenarios on identified waste types relative to the base case scenario. The base volume scenario was assumed to reflect current requirements at the disposal sites as well as the regulatory views. The high volume scenario was assumed to reflect the most conservative criteria as incorporated in some compact host state requirements. The low volume scenario was assumed to reflect the 10 CFR Part 61 criteria as applicable to both shallow land burial facilities and to practices that could be employed to reduce the generation of Class C waste types

Gulf of Mexico sales 147 and 150: Central and western planning areas. Draft environmental impact statement. Volume 1. Sections I through IV.C. Draft report

International Nuclear Information System (INIS)

1993-04-01

The Draft Environmental Impact Statement (EIS) covers the proposed 1994 Gulf of Mexico OCS oil and gas lease sales (Central Gulf of Mexico Sale 147 (March 1994) and Western Gulf of Mexico Sale 150 (August 1994)). The document includes the purpose and background of the proposed actions, the alternatives, the description of the affected environment, and the potential environmental impacts of the proposed actions and alternatives. Proposed mitigating measures and their effects are analyzed, in addition to potential cumulative impacts resulting from proposed activities

Single-layer group IV-V and group V-IV-III-VI semiconductors: Structural stability, electronic structures, optical properties, and photocatalysis

Science.gov (United States)

Lin, Jia-He; Zhang, Hong; Cheng, Xin-Lu; Miyamoto, Yoshiyuki

2017-07-01

Recently, single-layer group III monochalcogenides have attracted both theoretical and experimental interest at their potential applications in photonic devices, electronic devices, and solar energy conversion. Excited by this, we theoretically design two kinds of highly stable single-layer group IV-V (IV =Si ,Ge , and Sn; V =N and P) and group V-IV-III-VI (IV =Si ,Ge , and Sn; V =N and P; III =Al ,Ga , and In; VI =O and S) compounds with the same structures with single-layer group III monochalcogenides via first-principles simulations. By using accurate hybrid functional and quasiparticle methods, we show the single-layer group IV-V and group V-IV-III-VI are indirect bandgap semiconductors with their bandgaps and band edge positions conforming to the criteria of photocatalysts for water splitting. By applying a biaxial strain on single-layer group IV-V, single-layer group IV nitrides show a potential on mechanical sensors due to their bandgaps showing an almost linear response for strain. Furthermore, our calculations show that both single-layer group IV-V and group V-IV-III-VI have absorption from the visible light region to far-ultraviolet region, especially for single-layer SiN-AlO and SnN-InO, which have strong absorption in the visible light region, resulting in excellent potential for solar energy conversion and visible light photocatalytic water splitting. Our research provides valuable insight for finding more potential functional two-dimensional semiconductors applied in optoelectronics, solar energy conversion, and photocatalytic water splitting.

[Estimation of volume of pleural fluid and its impact on spirometrical parameters].

Science.gov (United States)

Karwat, Krzysztof; Przybyłowski, Tadeusz; Bielicki, Piotr; Hildebrand, Katarzyna; Nowacka-Mazurek, Magdalena; Nasiłowski, Jacek; Rubinsztajn, Renata; Chazan, Ryszarda

2014-03-01

In the course of various diseases, there is an accumulation of fluid in the pleural cavities. Pleural fluid accumulation causes thoracic volume expansion and reduction of volume lungs, leading to formation of restrictive disorders. The aim of the study was to estimate the volume of pleural fluid by ultrasonography and to search for the relationship between pleural fluid volume and spirometrical parameters. The study involved 46 patients (26 men, 20 women) aged 65.7 +/- 14 years with pleural effusions who underwent thoracentesis. Thoracentesis was preceded by ultrasonography of the pleura, spirometry test and plethysmography. The volume of the pleural fluid was calculated with the Goecke' and Schwerk' (GS) or Padykuła (P) equations. The obtained values were compared with the actual evacuated volume. The median volume of the removed pleural fluid was 950 ml. Both underestimated the evacuated volume (the median volume 539 ml for GS and 648 ml for P, respectively). Pleural fluid removal resulted in a statistically significant improvement in VC (increase 0.20 +/- 0.35 ; p Pleural fluid removal causes a significant improvement in lung function parameters. The analyzed equations for fluid volume calculation do not correlate with the actual volume.

Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume I. Program summary

International Nuclear Information System (INIS)

1980-06-01

This report summarizes the Nonproliferation Alternative Systems Assessment Program (NASAP): its background, its studies, and its results. The introductory chapter traces the growth of the issue of nuclear weapons proliferation and the organization and objectives of NASAP. Chapter 2 summarizes the program's assessments, findings, and recommendations. Each of Volumes II-VII reports on an individual assessment (Volumn II: Proliferation Resistance; Volume III: Resources and Fuel Cycle Facilities; Volume IV: Commercial Potential; Volume V: Economics and Systems Analysis; Volume VI: Safety and Environmental Considerations for Licensing; Volume VII: International Perspectives). Volume VIII (Advanced Concepts) presents a combined assessment of several less fully developed concepts, and Volume IX (Reactor and Fuel Cycle Descriptions) provides detailed descriptions of the reactor and fuel-cycle systems studied by NASAP

Characterization of Vertical Impact Device Acceleration Pulses Using Parametric Assessment: Phase IV Dual Impact Pulses

Science.gov (United States)

2017-01-04

support contractor , Infoscitex, conducted a series of tests to identify the performance capabilities of the Vertical Impact Device (VID) and the Warrior...Impact Response: Test Series 1 Data Summary for Carriage Test Cell VID Carriage Programmer Drop Ht . (in) Mean Velocity Change (m/s) Mean...Table 6. VID Impact Response: Test Series 1 Data Summary for Seat Pan Test Cell VID Carriage Programmer Drop Ht . (in) Mean Velocity

Steam Digest: Volume IV

Energy Technology Data Exchange (ETDEWEB)

2004-07-01

This edition of the Steam Digest is a compendium of 2003 articles on the technical and financial benefits of steam efficiency, presented by the stakeholders of the U.S. Department of Energy's BestPractices Steam effort.

Steam Digest Volume IV

Energy Technology Data Exchange (ETDEWEB)

None

2004-07-01

This edition of the Steam Digest is a compendium of 2003 articles on the technical and financial benefits of steam efficiency, presented by the stakeholders of the U.S. Department of Energy's BestPractices Steam effort.

Glycogen Storage Disease Type IV

DEFF Research Database (Denmark)

Bendroth-Asmussen, Lisa; Aksglaede, Lise; Gernow, Anne B

2016-01-01

molecular genetic analyses confirmed glycogen storage disease Type IV with the finding of compound heterozygosity for 2 mutations (c.691+2T>C and c.1570C>T, p.R524X) in the GBE1 gene. We conclude that glycogen storage disease Type IV can cause early miscarriage and that diagnosis can initially be made...

IV&V Project Assessment Process Validation

Science.gov (United States)

Driskell, Stephen

2012-01-01

The Space Launch System (SLS) will launch NASA's Multi-Purpose Crew Vehicle (MPCV). This launch vehicle will provide American launch capability for human exploration and travelling beyond Earth orbit. SLS is designed to be flexible for crew or cargo missions. The first test flight is scheduled for December 2017. The SLS SRR/SDR provided insight into the project development life cycle. NASA IV&V ran the standard Risk Based Assessment and Portfolio Based Risk Assessment to identify analysis tasking for the SLS program. This presentation examines the SLS System Requirements Review/System Definition Review (SRR/SDR), IV&V findings for IV&V process validation correlation to/from the selected IV&V tasking and capabilities. It also provides a reusable IEEE 1012 scorecard for programmatic completeness across the software development life cycle.

Dissimilatory Fe(III) and Mn(IV) reduction.

Science.gov (United States)

Lovley, D R

1991-06-01

The oxidation of organic matter coupled to the reduction of Fe(III) or Mn(IV) is one of the most important biogeochemical reactions in aquatic sediments, soils, and groundwater. This process, which may have been the first globally significant mechanism for the oxidation of organic matter to carbon dioxide, plays an important role in the oxidation of natural and contaminant organic compounds in a variety of environments and contributes to other phenomena of widespread significance such as the release of metals and nutrients into water supplies, the magnetization of sediments, and the corrosion of metal. Until recently, much of the Fe(III) and Mn(IV) reduction in sedimentary environments was considered to be the result of nonenzymatic processes. However, microorganisms which can effectively couple the oxidation of organic compounds to the reduction of Fe(III) or Mn(IV) have recently been discovered. With Fe(III) or Mn(IV) as the sole electron acceptor, these organisms can completely oxidize fatty acids, hydrogen, or a variety of monoaromatic compounds. This metabolism provides energy to support growth. Sugars and amino acids can be completely oxidized by the cooperative activity of fermentative microorganisms and hydrogen- and fatty-acid-oxidizing Fe(III) and Mn(IV) reducers. This provides a microbial mechanism for the oxidation of the complex assemblage of sedimentary organic matter in Fe(III)- or Mn(IV)-reducing environments. The available evidence indicates that this enzymatic reduction of Fe(III) or Mn(IV) accounts for most of the oxidation of organic matter coupled to reduction of Fe(III) and Mn(IV) in sedimentary environments. Little is known about the diversity and ecology of the microorganisms responsible for Fe(III) and Mn(IV) reduction, and only preliminary studies have been conducted on the physiology and biochemistry of this process.

Assembling filamentous phage occlude pIV channels.

Science.gov (United States)

Marciano, D K; Russel, M; Simon, S M

2001-07-31

Filamentous phage f1 is exported from its Escherichia coli host without killing the bacterial cell. Phage-encoded protein pIV, which is required for phage assembly and secretion, forms large highly conductive channels in the outer membrane of E. coli. It has been proposed that the phage are extruded across the bacterial outer membrane through pIV channels. To test this prediction, we developed an in vivo assay by using a mutant pIV that functions in phage export but whose channel opens in the absence of phage extrusion. In E. coli lacking its native maltooligosacharride transporter LamB, this pIV variant allowed oligosaccharide transport across the outer membrane. This entry of oligosaccharide was decreased by phage production and still further decreased by production of phage that cannot be released from the cell surface. Thus, exiting phage block the pIV-dependent entry of oligosaccharide, suggesting that phage occupy the lumen of pIV channels. This study provides the first evidence, to our knowledge, for viral exit through a large aqueous channel.

Non-equilibrium ionization by a periodic electron beam. II. Synthetic Si IV and O IV transition region spectra

Science.gov (United States)

Dzifčáková, Elena; Dudík, Jaroslav

2018-03-01

Context. Transition region (TR) spectra typically show the Si IV 1402.8 Å line to be enhanced by a factor of 5 or more compared to the neighboring O IV 1401.2 Å, contrary to predictions of ionization equilibrium models and the Maxwellian distribution of particle energies. Non-equilibrium effects in TR spectra are therefore expected. Aims: To investigate the combination of non-equilibrium ionization and high-energy particles, we apply the model of the periodic electron beam, represented by a κ-distribution that recurs at periods of several seconds, to plasma at chromospheric temperatures of 104 K. This simple model can approximate a burst of energy release involving accelerated particles. Methods: Instantaneous time-dependent charge states of silicon and oxygen were calculated and used to synthesize the instantaneous and period-averaged spectra of Si IV and O IV. Results: The electron beam drives the plasma out of equilibrium. At electron densities of Ne = 1010 cm-3, the plasma is out of ionization equilibrium at all times in all cases we considered, while for a higher density of Ne = 1011 cm-3, ionization equilibrium can be reached toward the end of each period, depending on the conditions. In turn, the character of the period-averaged synthetic spectra also depends on the properties of the beam. While the case of κ = 2 results in spectra with strong or even dominant O IV, higher values of κ can approximate a range of observed TR spectra. Spectra similar to typically observed spectra, with the Si IV 1402.8 Å line about a factor 5 higher than O IV 1401.2 Å, are obtained for κ = 3. An even higher value of κ = 5 results in spectra that are exclusively dominated by Si IV, with negligible O IV emission. This is a possible interpretation of the TR spectra of UV (Ellerman) bursts, although an interpretation that requires a density that is 1-3 orders of magnitude lower than for equilibrium estimates. Movies associated to Fig. A.1 are available at http://https://www.aanda.org

Contrast media osmolality and plasma volume changes

International Nuclear Information System (INIS)

Hine, A.L.; Lui, D.; Dawson, P.; Middlesex Hospital, London

1985-01-01

A theoretical and experimental study of the plasma volume expansion consequent on the hyperosmolality of contrast media is presented. In the case of the ratio 1.5 media theory and experiment coincide closely but in the case of the ratio 3 media the observed changes exceed the predicted. It is proposed that this is due partly to the slower diffusion of the ratio 3 media out of the intravascular space and partly due to the fact that the osmotic load presented by these media is greater than would be expected from a study of their commercial solutions in which osmolality is reduced by molecular aggregation. The implications for the relative haemodynamic effects of different contrast media are discussed. The osmotic effects of contrast media also play a part in determining the image quality achievable in intravenous digital subtraction angiography (IV-DSA). It is predicted that ratio 3 contrast media will give better quality images in IV-DSA than ratio 1.5 media. (orig.)

'Dipeptidyl peptidase-IV activity and/or structure homologs' (DASH) in growth-modulated glioma cell lines

Czech Academy of Sciences Publication Activity Database

Šedo, Aleksi; Bušek, P.; Scholzová, E.; Malík, Radek; Vlašicová, K.; Janáčková, S.; Mareš, Vladislav

2004-01-01

Roč. 385, č. 6 (2004), s. 557-559 ISSN 1431-6730 R&D Projects: GA ČR GA301/02/0962 Institutional research plan: CEZ:AV0Z5011922 Keywords : brain tumors * glioma cells * DPP-IV Subject RIV: FD - Oncology ; Hematology Impact factor: 3.598, year: 2004

The impact of preload reduction with head-up tilt testing on longitudinal and transverse left ventricular mechanics: a study utilizing deformation volume analysis.

Science.gov (United States)

Schneider, Caroline; Forsythe, Lynsey; Somauroo, John; George, Keith; Oxborough, David

2018-03-01

Left ventricular (LV) function is dependent on load, intrinsic contractility and relaxation with a variable impact on specific mechanics. Strain (ε) imaging allows the assessment of cardiac function; however, the direct relationship between volume and strain is currently unknown. The aim of this study was to establish the impact of preload reduction through head-up tilt (HUT) testing on simultaneous left ventricular (LV) longitudinal and transverse function and their respective contribution to volume change. A focused transthoracic echocardiogram was performed on 10 healthy male participants (23 ± 3 years) in the supine position and following 1 min and 5 min of HUT testing. Raw temporal longitudinal ε (Ls) and transverse ε (Ts) values were exported and divided into 5% increments across the cardiac cycle and corresponding LV volumes were traced at each 5% increment. This provided simultaneous LV longitudinal and transverse ε and volume loops (deformation volume analysis - DVA). There was a leftward shift of the ε-volume loop from supine to 1 min and 5 min of HUT ( P  transverse thickening from supine to 1 min, which was further augmented at 5 min ( P  = 0.018). Preload reduction occurs within 1 min of HUT but does not further reduce at 5 min. This decline is associated with a decrease in longitudinal ε and concomitant increase in transverse ε. Consequently, augmented transverse relaxation appears to be an important factor in the maintenance of LV filling in the setting of reduced preload. DVA provides information on the relative contribution of mechanics to a change in LV volume and may have a role in the assessment of clinical populations. © 2018 The authors.

Solubility study of Tc(IV) oxides

International Nuclear Information System (INIS)

Liu, D.J.; Fan, X.H.

2005-01-01

The deep geological disposal of the high level radioactive wastes is expected to be a safer disposal method in most countries. The long-lived fission product 99 Tc is present in large quantities in nuclear wastes and its chemical behavior in aqueous solution is of considerable interest. Under oxidizing conditions technetium exists as the anionic species TcO 4 - whereas under the reducing conditions, expected to exist in a deep geological repository, it is generally predicted that technetium will be present as TcO 2 ·nH 2 O. Hence, the mobility of Tc(IV) in reducing groundwater may be limited by the solubility of TcO 2 ·nH 2 O under these conditions. Due to this fact it is important to investigate the solubility of TcO 2 ·nH 2 O. The solubility determines the release of radionuclides from waste form and is used as a source term in radionuclide migration analysis in performance assessment of radioactive waste repository. Technetium oxide was prepared by reduction of a technetate solution with Sn 2 + . The solubility of Tc(IV) oxide has been determined in simulated groundwater and redistilled water under aerobic and anaerobic conditions. The effects of pH and CO 3 2- concentration of solution on solubility of Tc(IV) oxide were studied. The concentration of total technetium and Tc(IV) species in the solutions were periodically determined by separating the oxidized and reduced technetium species using a solvent extraction procedure and counting the beta activity of the 99 Tc with a liquid scintillation counter. The experimental results show that the rate of oxidation of Tc(IV) in simulated groundwater and redistilled water is about (1.49-1.86) x 10 -9 mol/(L·d) under aerobic conditions, but Tc(IV) in simulated groundwater and redistilled water is not oxidized under anaerobic conditions. Under aerobic or anaerobic conditions the solubility of Tc(IV) oxide in simulated groundwater and redistilled water is equal on the whole after centrifugation or ultrafiltration. The

The Contribution of IVS to IGGOS

Science.gov (United States)

Nothnagel, A.

2002-05-01

Since its inauguration in 1999, the International VLBI Service for Geodesy and Astrometry has made significant progress in the coordination and utilisation of worldwide VLBI resources. Improving the visibility of the IVS components to a wider public in turn led to a higher motivation of the individuals to contribute to the global effort. Not only the number of IVS components but also their investments in terms of funds and manpower demonstrate the increased awareness of the importance of this joint international endeavour. The different demands of the users but also of the contributors often require the definition of priorities which are only being acceptable due to the existence of a strong umbrella organisation like the IVS. Significant progress has also been made in the area of routine data analysis and combination of results. By now, six IVS Analysis Centers provide the redundancy necessary for a robust combination of the results. The use of ITRF2000 station coordinates as the basis for the IVS combined EOP series is the most recent step towards the generation of a consistent chain from the quasi-inertial frame of radio sources to system Earth.

Acute extracellular fluid volume changes increase ileocolonic resistance to saline flow in anesthetized dogs

Directory of Open Access Journals (Sweden)

Santiago Jr. A.T.

1997-01-01

Full Text Available We determined the effect of acute extracellular fluid volume changes on saline flow through 4 gut segments (ileocolonic, ileal, ileocolonic sphincter and proximal colon, perfused at constant pressure in anesthetized dogs. Two different experimental protocols were used: hypervolemia (iv saline infusion, 0.9% NaCl, 20 ml/min, volume up to 5% body weight and controlled hemorrhage (up to a 50% drop in mean arterial pressure. Mean ileocolonic flow (N = 6 was gradually and significantly decreased during the expansion (17.1%, P<0.05 and expanded (44.9%, P<0.05 periods while mean ileal flow (N = 7 was significantly decreased only during the expanded period (38%, P<0.05. Mean colonic flow (N = 7 was decreased during expansion (12%, P<0.05 but returned to control levels during the expanded period. Mean ileocolonic sphincter flow (N = 6 was not significantly modified. Mean ileocolonic flow (N = 10 was also decreased after hemorrhage (retracted period by 17% (P<0.05, but saline flow was not modified in the other separate circuits (N = 6, 5 and 4 for ileal, ileocolonic sphincter and colonic groups, respectively. The expansion effect was blocked by atropine (0.5 mg/kg, iv both on the ileocolonic (N = 6 and ileal (N = 5 circuits. Acute extracellular fluid volume retraction and expansion increased the lower gastrointestinal resistances to saline flow. These effects, which could physiologically decrease the liquid volume being supplied to the colon, are possible mechanisms activated to acutely balance liquid volume deficit and excess.

Purification, identification and molecular mechanism of two dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from Antarctic krill (Euphausia superba) protein hydrolysate.

Science.gov (United States)

Ji, Wei; Zhang, Chaohua; Ji, Hongwu

2017-10-01

Dipeptidyl peptidase IV (DPP-IV) played an important role in blood glucose regulation. Inhibition of DPP-IV may improve glycemic control in diabetics by preventing the rapid breakdown of incretin hormones and prolonging their physiological action. In this study, Antarctic krill (Euphausia superba) protein was hydrolyzed using animal proteolytic enzymes. The hydrolysate was purified sequentially by ultrafiltration, gel filtration chromatography and reversed phase high-performance liquid chromatography (RP-HPLC). DPP-IV inhibitory activity of the fractions achieved from Antarctic krill protein was determined by DPP-IV screening reagent kit. Two purified peptides were identified by Xevo G2-XS QTof mass spectrometer (QTOF-MS). One peptide purified was Ala-Pro (AP) with IC 50 values of 0.0530mg/mL, the other Ile-Pro-Ala (IPA) with IC 50 values of 0.0370mg/mL. They both exhibited strong DPP-IV inhibitory activity. The molecular docking analysis revealed that DPP-IV inhibition by AP and IPA was mainly due to formation of a strong interaction surface force with the 91-96 and 101-105 amino acids of the DPP-IV. Our results suggested that the protein hydrolysate from Antarctic krill can be considered as a promising natural source of DPP-IV inhibitory peptides in the management of diabetes. Copyright © 2017 Elsevier B.V. All rights reserved.

Impact of spinal anaesthesia on peri-operative lung volumes in obese and morbidly obese female patients.

Science.gov (United States)

Regli, A; von Ungern-Sternberg, B S; Reber, A; Schneider, M C

2006-03-01

Although obesity predisposes to postoperative pulmonary complications, data on the relationship between body mass index (BMI) and peri-operative respiratory performance are limited. We prospectively studied the impact of spinal anaesthesia, obesity and vaginal surgery on lung volumes measured by spirometry in 28 patients with BMI 30-40 kg.m(-2) and in 13 patients with BMI > or = 40 kg.m(-2). Vital capacity, forced vital capacity, forced expiratory volume in 1 s, mid-expiratory and peak expiratory flows were measured during the pre-operative visit (baseline), after effective spinal anaesthesia with premedication, and after the operation at 20 min, 1 h, 2 h, and 3 h (after mobilisation). Spinal anaesthesia and premedication were associated with a significant decrease in spirometric parameters. Spinal anaesthesia and premedication were associated with a significant decrease in spirometric parameters; mean (SD) vital capacities were - 19% (6.4) in patients with BMI 30-40 kg.m(-2) and - 33% (9.0) in patients with BMI > 40 kg.m(-2). The decrease of lung volumes remained constant for 2 h, whereas 3 h after the operation and after mobilisation, spirometric parameters significantly improved in all patients. This study showed that both spinal anaesthesia and obesity significantly impaired peri-operative respiratory function.

On the Importance of the Nonequilibrium Ionization of Si IV and O IV and the Line of Sight in Solar Surges

Science.gov (United States)

Nóbrega-Siverio, D.; Moreno-Insertis, F.; Martínez-Sykora, J.

2018-05-01

Surges are ubiquitous cool ejections in the solar atmosphere that often appear associated with transient phenomena like UV bursts or coronal jets. Recent observations from the Interface Region Imaging Spectrograph show that surges, although traditionally related to chromospheric lines, can exhibit enhanced emission in Si IV with brighter spectral profiles than for the average transition region (TR). In this paper, we explain why surges are natural sites to show enhanced emissivity in TR lines. We performed 2.5D radiative-MHD numerical experiments using the Bifrost code including the nonequilibrium (NEQ) ionization of silicon and oxygen. A surge is obtained as a by-product of magnetic flux emergence; the TR enveloping the emerged domain is strongly affected by NEQ effects: assuming statistical equilibrium would produce an absence of Si IV and O IV ions in most of the region. Studying the properties of the surge plasma emitting in the Si IV λ1402.77 and O IV λ1401.16 lines, we find that (a) the timescales for the optically thin losses and heat conduction are very short, leading to departures from statistical equilibrium, and (b) the surge emits in Si IV more and has an emissivity ratio of Si IV to O IV larger than a standard TR. Using synthetic spectra, we conclude the importance of line-of-sight effects: given the involved geometry of the surge, the line of sight can cut the emitting layer at small angles and/or cross it multiple times, causing prominent, spatially intermittent brightenings in both Si IV and O IV.

Gender specific association of TP53 polymorphisms (EX4 215G>C Arg72Pro, IVS3+40-41ins16, and IVS6+62G>A), with risk of oral cancer subtypes and overall survival of the patients.

Science.gov (United States)

Nagam, Srivani L S S; Katta, Saritha; Prasad, Vidudala V T S

2017-03-01

Reports on the association of TP53 polymorphisms with oral cancer are not only limited but also not specific to site and/or gender. Hence, we examined the effect of TP53 polymorphisms (EX4 215G>C, IVS3+40-41ins16 and IVS6+62G>A) on buccal mucosa cancer (BMC) and tongue cancer (TC) risk, survival of patients in relation to risk and clinical factors, gender wise (excepting for estimating hazards ratio [HR]), using Fisher's Exact Test, Kaplan-Meier analysis, and Cox-proportional hazards models. The exonic polymorphism increased BMC and TC risk in males by 2-4-fold. The IVS3+40-41ins16 was protective against BMC and TC in both genders, whereas IVS6+62G>A protected only males against TC. Genotype combinations and haplotypes which altered the risk of cancers in males and females were different. TC males, aged 40-44 years and females, aged 55-59 years survived better than BMC patients. The IVS3+40-41ins16 polymorphism differentially impacted survival of female patients exposed to tobacco. TC patients with EX4 215GC with lymphovascular spread (LVS) and metastasis exhibited higher HR while, patients with EX4 215CC and perineural invasion (PNI) showed lower HR. Impact of the intronic variants along with clinical parameters on survival and HR estimates varied between BMC and TC. Our bioinformatics analysis revealed the presence of CTCF binding site within TP53 gene. In conclusion, the polymorphisms altered risk and survival of BMC and TC in a gender specific manner, which varied with mode of tobacco and/or alcohol use. The current study, therefore underscores strong need for research, stratified by tumor site and gender. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Synthesis and spectroscopic studies of mono- and dicyclopentadienyl titanium (IV)/zirconium (IV) derivatives with S-alkyl-β-N-(acetylferrocenyl) methylene dithiocarbazates

International Nuclear Information System (INIS)

Srivastava, B.K.; Srivastava, S.K.; Pandey, O.P.; Sengupta, S.K.

1996-01-01

The reactions of dicyclopentadienyl titanium (IV)/zirconium (IV) dichloride and monocyclopentadienyl titanium (IV) trichloride with thio-Schiff bases (LH), derived by the condensation of S-methyl/ethyl/propyl dithiocarbazic acid and acetylferrocene have been carried out under inert atmosphere and anhydrous conditions in different stoichiometric ratios. Complexes of the types Cp 2 M(L)Cl, CpM(L) 2 Cl (M= Ti(IV) or Zr(IV)), CpTi(L)Cl 2 , CpTi(L) 2 Cl are synthesised and characterized by elemental analysis, electrical conductance, magnetic moment and spectral (electronic, infrared, 1 H NMR) data. (author). 12 refs., 1 tab

SAGE IV Pathfinder

Data.gov (United States)

National Aeronautics and Space Administration — Utilizing a unique, new occultation technique involving imaging, the SAGE IV concept will meet or exceed the quality of previous SAGE measurements at a small...

Facile and reversible formation of iron(III)-oxo-cerium(IV) adducts from nonheme oxoiron(IV) complexes and cerium(III)

Energy Technology Data Exchange (ETDEWEB)

Draksharapu, Apparao; Rasheed, Waqas; Klein, Johannes E.M.N.; Que, Lawrence Jr. [Department of Chemistry and Center for Metals in Biocatalysis, University of Minnesota, Minneapolis, MN (United States)

2017-07-24

Ceric ammonium nitrate (CAN) or Ce{sup IV}(NH{sub 4}){sub 2}(NO{sub 3}){sub 6} is often used in artificial water oxidation and generally considered to be an outer-sphere oxidant. Herein we report the spectroscopic and crystallographic characterization of [(N4Py)Fe{sup III}-O-Ce{sup IV}(OH{sub 2})(NO{sub 3}){sub 4}]{sup +} (3), a complex obtained from the reaction of [(N4Py)Fe{sup II}(NCMe)]{sup 2+} with 2 equiv CAN or [(N4Py)Fe{sup IV}=O]{sup 2+} (2) with Ce{sup III}(NO{sub 3}){sub 3} in MeCN. Surprisingly, the formation of 3 is reversible, the position of the equilibrium being dependent on the MeCN/water ratio of the solvent. These results suggest that the Fe{sup IV} and Ce{sup IV} centers have comparable reduction potentials. Moreover, the equilibrium entails a change in iron spin state, from S=1 Fe{sup IV} in 2 to S=5/2 in 3, which is found to be facile despite the formal spin-forbidden nature of this process. This observation suggests that Fe{sup IV}=O complexes may avail of reaction pathways involving multiple spin states having little or no barrier. (copyright 2017 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

Cuparane sesquiterpenes from Laurencia natalensis Kylin as inhibitors of alpha-glucosidase, dipeptidyl peptidase IV and xanthine oxidase

Czech Academy of Sciences Publication Activity Database

Rengasamy, K.R.R.; Poštová Slavětínská, Lenka; Kulkarni, M. G.; Stirk, W. A.; Van Staden, J.

2017-01-01

Roč. 25, Jul (2017), s. 178-183 ISSN 2211-9264 Institutional support: RVO:61388963 Keywords : 1-deoxyalgoane * dipeptidyl peptidase IV * diabetes * gout * Laurencia natalensis Subject RIV: CC - Organic Chemistry OBOR OECD: Organic chemistry Impact factor: 3.994, year: 2016

Plasma metabolism of apolipoprotein A-IV in humans

International Nuclear Information System (INIS)

Ghiselli, G.; Krishnan, S.; Beigel, Y.; Gotto, A.M. Jr.

1986-01-01

As assessed by molecular sieve chromatography and quantitation by a specific radioimmunoassay, apoA-IV is associated in plasma with the triglyceride-rich lipoproteins, to a high density lipoprotein (HDL) subfraction of smaller size than HDL3, and to the plasma lipoprotein-free fraction (LFF). In this study, the turnover of apoA-IV associated to the triglyceride-rich lipoproteins, HDL and LFF was investigated in vivo in normal volunteers. Human apoA-IV isolated from the thoracic duct lymph chylomicrons was radioiodinated and incubated with plasma withdrawn from normal volunteers after a fatty meal. Radioiodinated apoA-IV-labeled triglyceride-rich lipoproteins, HDL, and LFF were then isolated by chromatography on an AcA 34 column. Shortly after the injection of the radioiodinated apoA-IV-labeled triglyceride-rich lipoproteins, most of the radioactivity could be recovered in the HDL and LFF column fractions. On the other hand, when radioiodinated apoA-IV-labeled HDL or LFF were injected, the radioactivity remained with the originally injected fractions at all times. The residence time in plasma of 125 I-labeled apoA-IV, when injected in association with HDL or LFF, was 1.61 and 0.55 days, respectively. When 125 I-labeled apoA-IV was injected as a free protein, the radioactivity distributed rapidly among the three plasma pools in proportion to their mass. The overall fractional catabolic rate of apoA-IV in plasma was measured in the three normal subjects and averaged 1.56 pools per day. The mean degradation rate of apoA-IV was 8.69 mg/kg X day

Resource conservation and recovery act draft hazardous waste facility permit: Waste Isolation Pilot Plant (WIPP). Attachments: Volume 4 of 4

Energy Technology Data Exchange (ETDEWEB)

1993-08-01

Volume IV contains the following attachments for Module IV: VOC monitoring plan for bin-room tests (Appendix D12); bin emission control and VOC monitoring system drawings; bin scale test room ventilation drawings; WIPP supplementary roof support system, underground storage area, room 1, panel 1, DOE/WIPP 91-057; and WIPP supplementary roof support system, room 1, panel 1, geotechnical field data analysis bi-annual report, DOE/WIPP 92-024.

Gender-linked impact of epicardial adipose tissue volume in patients who underwent coronary artery bypass graft surgery or non-coronary valve surgery

OpenAIRE

Maimaituxun, Gulinu; Shimabukuro, Michio; Salim, Hotimah Masdan; Tabata, Minoru; Yuji, Daisuke; Morimoto, Yoshihisa; Akasaka, Takeshi; Matsuura, Tomomi; Yagi, Shusuke; Fukuda, Daiju; Yamada, Hirotsugu; Soeki, Takeshi; Sugimoto, Takaki; Tanaka, Masashi; Takanashi, Shuichiro

2017-01-01

Background Traditional and non-traditional risk factors for atherosclerotic cardiovascular disease (ASCVD) are different between men and women. Gender-linked impact of epicardial adipose tissue volume (EATV) in patients undergoing coronary artery bypass grafting (CABG) remains unknown. Methods Gender-linked impact of EATV, abdominal fat distribution and other traditional ASCVD risk factors were compared in 172 patients (men: 115; women: 57) who underwent CABG or non-coronary valvular surgery ...

Soil Properties Database of Spanish Soils Volume IV.- Valencia and Murcia

International Nuclear Information System (INIS)

Trueba, C.; Millan, R.; Schmid, T.; Roquero, C; Magister, M.

1998-01-01

The soil vulnerability determines the sensitivity of the soil after an accidental radioactive contamination due to Cs-137 and Sr-90. The Departamento de Impacto Ambiental de la Energia of CIEMAT is carrying out an assessment of the radiological vulnerability of the different Spanish soils found on the Iberian Peninsula. This requires the knowledge of the soil properties for the various types of existing soils. In order to achieve this aim, a bibliographical compilation of soil profiles has been made to characterize the different soil types and create a database of their properties. Depending on the year of publication and the type of documentary source, the information compiled from the available bibliography is very heterogeneous. Therefore, an important effort has been made to normalize and process the information prior to its incorporation to the database. This volume presents the criteria applied to normalize and process the data as well as the soil properties of the various soil types belonging to the Comunidades Autonomas de Valencia and Murcia. (Author) 63 refs

Collagen type IV at the fetal-maternal interface

OpenAIRE

Oefner, C M; Sharkey, A; Gardner, L; Critchley, H; Oyen, M; Moffett, A

2015-01-01

Introduction Extracellular matrix proteins play a crucial role in influencing the invasion of trophoblast cells. However the role of collagens and collagen type IV (col-IV) in particular at the implantation site is not clear. Methods Immunohistochemistry was used to determine the distribution of collagen types I, III, IV and VI in endometrium and decidua during the menstrual cycle and the first trimester of pregnancy. Expression of col-IV alpha chains during the reproductive cycle ...

Relationship between Contrast Enhancement of the Perivascular Space in the Basal Ganglia and Endolymphatic Volume Ratio.

Science.gov (United States)

Ohashi, Toshio; Naganawa, Shinji; Katagiri, Toshio; Kuno, Kayao

2018-01-10

We routinely obtain the endolymphatic hydrops (EH) image using heavily T 2 -weighted three dimensional-fluid attenuated inversion recovery (hT 2 w-3D-FLAIR) imaging at 4 hours after intravenous administration of a single-dose of gadolinium-based contrast media (IV-SD-GBCM). While repeating the examination, we speculated that the contrast enhancement of the perivascular space (PVS) in the basal ganglia might be related to the degree of EH. Therefore, the purpose of this study was to investigate the relationship between the endolymphatic volume ratio (%EL volume ) and the signal intensity of the PVS (SI-PVS). In 20 patients with a suspicion of EH, a heavily T 2 -weighted 3D-turbo spin echo sequence for MR cisternography (MRC) and an hT 2 w-3D-FLAIR as a positive perilymph image (PPI) were obtained at 4 hours after IV-SD-GBCM. The %EL volume of the cochlea and the vestibule were measured on the previously reported HYDROPS2-Mi2 image. The PVS in the basal ganglia was segmented on MRC using a region-growing method. The PVS regions were copied and pasted onto the PPI, and the SI-PVS was measured. The larger value of the right and the left ears was employed as the %EL volume , and the weighted average of both sides was employed as the SI-PVS. The correlation between the %EL volume and the SI-PVS was evaluated. There was a strong negative linear correlation between the %EL volume of the cochlea and the SI-PVS (r = -0.743, P < 0.001); however, there was no significant correlation between the %EL volume of the vestibule and the SI-PVS (r = -0.267, P = 0.256). There was a strong negative correlation between the cochlear %EL volume and the SI-PVS. Contrast enhancement of PVS might be a biomarker of EH.

On the stabilization of NbV-solutions by ZrIV and HfIV

International Nuclear Information System (INIS)

Soerensen, E.; Bjerre, A.B.

1987-11-01

Niobium cannot be separated from zirconium or hafnium when these elements occur together in solution with common anions such as Cl- and SO 4 --. This is ascribed to the copolymerisation of Nb v and the hydrolyzed ionic species of Zr IV v and Hf IV by which the colloidal particles are masked as Zr- and Hf-compounds. In HCl the particles are positively charged as opposed to when they are in sulphate solution where the Zr- and Hf- sulphate complexes confer a negative charge. The two cases are considered separately. (author)

Synthesis and evaluation of artificial antigens for astragaloside IV

Directory of Open Access Journals (Sweden)

Sheng-lan Yu

Full Text Available The objective of this study was to produce artificial antigens for astragaloside IV that could be used to prepare antibodies against astragaloside IV screened in Radix astragali (Astragalus membranaceus (Fisch Bunge, Fabaceae and its preparations, using an indirect ELISA. Astragaloside IV was coupled to carrier proteins, bovine serum albumin and ovalbumin using the sodium periodate method and was then evaluated using SDS-PAGE, MALDI-TOF MS and animal immunizations. The coupling ratio of astragaloside IV to bovine serum albumin ratio was determined to be thirteen, and the indirect ELISA demonstrated that three groups of mice immunized with astragaloside IV-bovine serum albumin produced anti-astragaloside IV- bovine serum albumin-specific antibody, with a minimum serum titer of 1:9600. A method for synthesizing highly immunogenic astragaloside IV artificial antigens was successfully developed thus indicating its feasibility in the establishment of a fast immunoassay for astragaloside IV content determination in Radix astragali and its products.

Niger Republic Mineral Planning : Part IV - first volume : Main mineral substances specific study and their geological context; Plan Mineral de la Republique du Niger : Tome IV - 1er volume : Etude specifique des principales substances minerals et leur contexte geologique

Energy Technology Data Exchange (ETDEWEB)

Franconi, Antoine; Joo' , Julien; Zibo, Idde

1981-07-01

This volume contains the detailed study of mineral substances industrially exploited to date : uranium, coal, non metallic building materials and public activities, and non conventionally exploited substances, that are : tin, columbite-tantalite, tungsten, gold, phosphates and evaporates. [French] Ce volume contient l'etude detaillee des substances minerals exploitees industriellement a ce jour : l'uranium, le charbon, les materiaux non metalliques de construction et de travaux publics et les substances exploitees artisanalement qui sont : l'etain, la Colombo-tantalite, le tungstene, l'or, les phosphates et les evaporates.

Market opportunities: U.S. - PADD IV

International Nuclear Information System (INIS)

Garner, R.P.

1997-01-01

The current supply and demand balance, the short and long term expectations and marketing opportunities for Canadian crude oil in PADD IV, the Rocky Mountain region in the US, were reviewed. It was suggested that market opportunities in PADD IV are derived from the following four factors: (1) crude oil declines within that area, (2) federal regulations, (3) competitive presence with markets, and (4) population growth. The overall conclusion was that Canadian producers and PADD IV refiners will be looking at an ever-growing relationship based on freight equalized world crude prices. 8 tabs., 5 figs

Report for 2011 from the Bordeaux IVS Analysis Center

Science.gov (United States)

Charlot, Patrick; Bellanger, Antoine; Bourda, Geraldine; Collioud, Arnaud; Baudry, Alain

2012-01-01

This report summarizes the activities of the Bordeaux IVS Analysis Center during the year 2011. The work focused on (i) regular analysis of the IVS-R1 and IVS-R4 sessions with the GINS software package; (ii) systematic VLBI imaging of the RDV sessions and calculation of the corresponding source structure index and compactness values; (iii) imaging of the sources observed during the 2009 International Year of Astronomy IVS observing session; and (iv) continuation of our VLBI observational program to identify optically-bright radio sources suitable for the link with the future Gaia frame. Also of importance is the enhancement of the IVS LiveWeb site which now comprises all IVS sessions back to 2003, allowing one to search past observations for session-specific information (e.g. sources or stations).

IRIS Responsiveness to Generation IV Road-map Goals

International Nuclear Information System (INIS)

Carelli, M.D.; Paramonov, D.V.; Petrovic, B.

2002-01-01

The DOE Generation IV road-map process is in its second and final year. Almost one hundred concepts submitted from all over the world have been reviewed against the Generation IV goals of resources sustainability; safety and reliability; and, economics. Advanced LWRs are taken as the reference point. IRIS (International Reactor Innovative and Secure), a 100-335 MWe integral light water reactor being developed by a vast international consortium led by Westinghouse, is one on the concepts being considered in the road-map and is perhaps the most visible representative of the concept set known as Integral Primary System Reactors (IPSR). This paper presents how IRIS satisfies the prescribed goals. The first goal of resource sustainability includes criteria like utilization of fuel resources, amount and toxicity of waste produced, environmental impact, proliferation and sabotage resistance. As a thermal reactor IRIS does not have the same fuel utilization as fast reactors. However, it has a significant flexibility in fuel cycles as it is designed to utilize either UO 2 or MOX with straight burn cycles of 4 to 10 years, depending on the fissile content. High discharge burnup and Pu recycling result in good fuel utilization and lower waste; IRIS has also attractive proliferation resistance characteristics, due to the reduced accessibility of the fuel. The safety and reliability goal include reliability, workers' exposure, robust safety features, models with well characterized uncertainty, source term and mechanisms of energy release, robust mitigation of accidents. IRIS is significantly better than advanced LWRs because of its safety by design which eliminates a variety of accidents such as LOCAs, its containment vessel coupled design which maintains the core safely covered during the accident sequences, its design simplification features such as no (or reduced) soluble boron, internal shielding and four-year refueling/maintenance interval which significantly reduce

Direct Bandgap Group IV Materials

Science.gov (United States)

2016-01-21

AFRL-AFOSR-JP-TR-2017-0049 Direct Bandgap group IV Materials Hung Hsiang Cheng NATIONAL TAIWAN UNIVERSITY Final Report 01/21/2016 DISTRIBUTION A...NAME(S) AND ADDRESS(ES) NATIONAL TAIWAN UNIVERSITY 1 ROOSEVELT RD. SEC. 4 TAIPEI CITY, 10617 TW 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING...14. ABSTRACT Direct bandgap group IV materials have been long sought for in both academia and industry for the implementation of photonic devices

Prognostic impact of metastatic pattern in stage IV breast cancer at initial diagnosis.

Science.gov (United States)

Leone, Bernardo Amadeo; Vallejo, Carlos Teodoro; Romero, Alberto Omar; Machiavelli, Mario Raúl; Pérez, Juan Eduardo; Leone, Julieta; Leone, José Pablo

2017-02-01

To analyze the prognostic influence of metastatic pattern (MP) compared with other biologic and clinical factors in stage IV breast cancer at initial diagnosis (BCID) and evaluate factors associated with specific sites of metastases (SSM). We evaluated women with stage IV BCID with known metastatic sites, reported to the Surveillance, Epidemiology and End Results program from 2010 to 2013. MP was categorized as bone-only, visceral, bone and visceral (BV), and other. Univariate and multivariate analyses determined the effects of each variable on overall survival (OS). Logistic regression examined factors associated with SSM. We included 9143 patients. Bone represented 37.5% of patients, visceral 21.9%, BV 28.8%, and other 11.9%. Median OS by MP was as follows: bone 38 months, visceral 21 months, BV 19 months, and other 33 months (P < 0.0001). Univariate analysis showed that higher number of metastatic sites had worse prognosis. In multivariate analysis, older age (hazard ratio 1.9), black race (hazard ratio 1.17), grade 3/4 tumors (hazard ratio 1.6), triple-negative (hazard ratio 2.24), BV MP (hazard ratio 2.07), and unmarried patients (hazard ratio 1.25) had significantly shorter OS. As compared with HR+/HER2- tumors, triple-negative and HR-/HER2+ had higher odds of brain, liver, lung, and other metastases. HR+/HER2+ had higher odds of liver metastases. All three subtypes had lower odds of bone metastases. There were substantial differences in OS according to MP. Tumor subtypes have a clear influence among other factors on SSM. We identified several prognostic factors that could guide therapy selection in treatment naïve patients.

Free-format RPG IV

CERN Document Server

Martin, Jim

2013-01-01

This how-to guide offers a concise and thorough introduction to the increased productivity, better readability, and easier program maintenance that comes with the free-format style of programming in RPG IV. Although free-format information is available in IBM manuals, it is not separated from everything else, thereby requiring hours of tedious research to track down the information needed. This book provides everything one needs to know to write RPG IV in the free-format style, and author Jim Martin not only teaches rules and syntax but also explains how this new style of coding has the pot

Preparation of some complexes of Th(IV) and U(IV) with tetradentate Schiff bases. The crystal structure of bis(N,N'-ethylenebis(3-methoxysalicylaldiminato)) thorium(IV) monopyridine

Energy Technology Data Exchange (ETDEWEB)

Hill, R J; Rickard, C E.F.; White, H E [Auckland Univ. (New Zealand). Dept. of Chemistry

1981-01-01

Complexes of Th(IV) and U(IV) with tetradentate Schiff bases derived from substituted salicylaldehydes have been prepared and characterised. The structure of bis(N,N'-ethylenebis(3-methoxysalicylaldiminato)) Th(IV) monopyridine has been determined by X-ray crystallographic methods. The crystals are triclinic, a = 13.468, b = 9.932, c = 16.552 A, ..cap alpha.. = 91.74, ..beta.. = 94.69, ..gamma.. = 93.03/sup 0/, space group P/sub 1//sup -/. The molecules are eight coordinate with a slightly distorted dodecahedral geometry with the imine nitrogen atoms in the dodecahedral A sites. The pyridine molecule is uncoordinated and functions in a space-filling role.

Features and prognostic impact of distant metastases in 45 dogs with de novo stage IV cutaneous mast cell tumours: A prospective study.

Science.gov (United States)

Pizzoni, S; Sabattini, S; Stefanello, D; Dentini, A; Ferrari, R; Dacasto, M; Giantin, M; Laganga, P; Amati, M; Tortorella, G; Marconato, L

2018-03-01

Distant metastases in dogs with cutaneous mast cell tumors (cMCT) are rare and incurable. The aims of this prospective study were to clarify the clinico-pathological features of stage IV cMCTs and to identify possible prognostic factors for progression-free interval (PFI) and survival time (ST). Dogs were eligible for recruitment if they had a previously untreated, histologically confirmed cMCT and if they underwent complete staging demonstrating stage IV disease. Dogs were uniformly followed-up, whereas treatment was not standardized and included no therapy, surgery, radiation therapy, chemotherapy, tyrosine-kinase inhibitors or a combination of these. 45 dogs with stage IV cMCT were enrolled. All dogs had distant metastatic disease, and 41 (91.1%) dogs had also metastasis in the regional lymph node. Histopathological grade and mutational status greatly varied among dogs. Median ST was 110 days. Notably, PFI and ST were independent of well-known prognostic factors, including anatomic site, histological grade, and mutational status. Conversely, tumor diameter >3 cm, more than 2 metastatic sites, bone marrow infiltration, and lack of tumor control at the primary site were confirmed to be negative prognostic factors by multivariate analysis. Currently, there is no satisfactory treatment for stage IV cMCT. Asymptomatic dogs with tumor diameter <3 cm and a low tumor burden, without bone marrow infiltration may be candidates for multimodal treatment. Stage IV dogs without lymph node metastasis may enjoy a surprisingly prolonged survival. The achievement of local tumor control seems to predict a better outcome in dogs with stage IV cMCT. © 2017 John Wiley & Sons Ltd.

78 FR 21491 - DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P.; Notice Seeking Exemption...

Science.gov (United States)

2013-04-10

... SMALL BUSINESS ADMINISTRATION [License No. 02/02-0662, 02/02-0661] DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that DeltaPoint Capital IV, L.P. and DeltaPoint...

Facing Contrast-Enhancing Gliomas: Perfusion MRI in Grade III and Grade IV Gliomas according to Tumor Area

Directory of Open Access Journals (Sweden)

Anna Luisa Di Stefano

2014-01-01

Full Text Available Tumoral neoangiogenesis characterizes high grade gliomas. Relative Cerebral Blood Volume (rCBV, calculated with Dynamic Susceptibility Contrast (DSC Perfusion-Weighted Imaging (PWI, allows for the estimation of vascular density over the tumor bed. The aim of the study was to characterize putative tumoral neoangiogenesis via the study of maximal rCBV with a Region of Interest (ROI approach in three tumor areas—the contrast-enhancing area, the nonenhancing tumor, and the high perfusion area on CBV map—in patients affected by contrast-enhancing glioma (grades III and IV. Twenty-one patients were included: 15 were affected by grade IV and 6 by grade III glioma. Maximal rCBV values for each patient were averaged according to glioma grade. Although rCBV from contrast-enhancement and from nonenhancing tumor areas was higher in grade IV glioma than in grade III (5.58 and 2.68; 3.01 and 2.2, resp., the differences were not significant. Instead, rCBV recorded in the high perfusion area on CBV map, independently of tumor compartment, was significantly higher in grade IV glioma than in grade III (7.51 versus 3.78, P=0.036. In conclusion, neoangiogenesis encompasses different tumor compartments and CBV maps appear capable of best characterizing the degree of neovascularization. Facing contrast-enhancing brain tumors, areas of high perfusion on CBV maps should be considered as the reference areas to be targeted for glioma grading.

[Forensic assessment of DSM-5 posttraumatic stress disorder: a commentary on the transition from DSM-IV-TR (I)].

Science.gov (United States)

Stevens, A; Fabra, M

2013-12-01

In May 2013 the American Psychiatric Association (APA) has released the latest and fifth edition of the diagnostic and statistical manual of mental disorders (DSM-5). Like its predecessor, the DSM-IV-TR, it will have considerable impact on the science of Psychiatry. The DSM-5 describes - actually available in English - the present medical knowledge about mental disorders. In the short run, German medical science and scientific medicolegal expertises will continue to rely on the German version of the DSM-IV-TR, however, they will be difficult to defend without bearing in mind the changes that DSM-5 brings about. This report discusses the transition from DSM-IV-TR to DSM-5 with regard to posttraumatic stress disorder (PTSD) and provides suggestions, how the criteria might be evaluated.

Implant volume as a prognostic variable in brachytherapy decision-making for malignant gliomas stratified by the RTOG recursive partitioning analysis

International Nuclear Information System (INIS)

Videtic, Gregory M.M.; Gaspar, Laurie E.; Zamorano, Lucia; Stitt, Larry W.; Fontanesi, James; Levin, Kenneth J.

2001-01-01

Purpose: When an initial retrospective review of malignant glioma patients (MG) undergoing brachytherapy was carried out using the Radiation Therapy Oncology Group (RTOG) recursive partitioning analysis (RPA) criteria, it revealed that glioblastoma multiforme (GBM) cases benefit the most from implant. In the present study, we focused exclusively on these GBM patients stratified by RPA survival class and looked at the relationship between survival and implanted target volume, to distinguish the prognostic value of volume in general and for a given GBM class. Methods and Materials: Between 1991 and 1998, 75 MG patients were treated with surgery, external beam radiation, and stereotactic iodine-125 (I-125) implant. Of these, 53 patients (70.7%) had GBMs, with 52 (98%) having target volume (TV) data for analysis. Stratification by RPA criteria showed 12, 26, 13, and 1 patients in classes III to VI, respectively. For analysis purposes, classes V and VI were merged. There were 27 (51.9%) male and 25 (48.1%) female patients. Mean age was 57.5 years (range 14-79). Median Karnofsky performance status (KPS) was 90 (range 50-100). Median follow-up time was 11 months (range 2-79). Results: At analysis, 18 GBM patients (34.6%) were alive and 34 (65.4%) were dead. Two-year and 5-year survivals were 42% and 17.5%, respectively, with a median survival time (MST) of 16 months. Two-year survivals and MSTs for the implanted GBM patients compared to the RTOG database were as follows: 74% vs. 35% and 28 months vs. 17.9 months for class III; 32% vs. 15% and 16 months vs. 11.1 months for class IV; 29% vs. 6% and 11 months vs. 8.9 months for class V/VI. Mean implanted TV was 15.5 cc (range 0.8-78), which corresponds to a spherical implant diameter of 3.1 cm. Plotting survival as a function of 5-cc TV increments suggested a trend toward poorer survival as the implanted volume increases. The impact of incremental changes in TV on survival within a given RPA class of GBMs was compared to the

Dipeptidyl peptidase IV inhibitory activity of protein hydrolyzates ...

African Journals Online (AJOL)

Background: Type 2 diabetes is a chronic metabolic disorder. Recently, dipeptidyl peptidase IV (DPP-IV) inhibitors that protect incretin hormones from being cleaved by DPP-IV have been used as drugs to control glycemia. This study examined the potential hypoglycemic effect of amaranth grain storage protein hydrolyzates ...

Centrifuge Impact Cratering Experiments

Science.gov (United States)

Schmidt, R. M.; Housen, K. R.; Bjorkman, M. D.

1985-01-01

The kinematics of crater growth, impact induced target flow fields and the generation of impact melt were determined. The feasibility of using scaling relationships for impact melt and crater dimensions to determine impactor size and velocity was studied. It is concluded that a coupling parameter determines both the quantity of melt and the crater dimensions for impact velocities greater than 10km/s. As a result impactor radius, a, or velocity, U cannot be determined individually, but only as a product in the form of a coupling parameter, delta U micron. The melt volume and crater volume scaling relations were applied to Brent crater. The transport of melt and the validity of the melt volume scaling relations are examined.

Is complete resection of high-risk stage IV neuroblastoma associated with better survival?

Science.gov (United States)

Yeung, Fanny; Chung, Patrick Ho Yu; Tam, Paul Kwong Hang; Wong, Kenneth Kak Yuen

2015-12-01

The role of surgery in the management of stage IV neuroblastoma is controversial. In this study, we attempted to study if complete tumor resection had any impact on event-free survival (EFS) and overall survival (OS). A retrospective analysis of patients with stage IV neuroblastoma between November 2000 and July 2014 in a tertiary referral center was performed. Demographics data, extent of surgical resection, and outcomes were analyzed. A total of 34 patients with stage IV neuroblastoma according to International Neuroblastoma Staging System (INSS) were identified. The median age at diagnosis and operation was 3.5 (±1.9) years and 3.8 (±2.0) years, respectively. Complete gross tumor resection (CTR) was achieved in twenty-four patients (70.1%), in which one of the patients had nephrectomy and another had distal pancreatectomy. Gross total resection (GTR) with removal of >95% of tumor was performed in six patients (17.6%) and subtotal tumor resection (STR) with removal of >50%, but <95% of tumor was performed in four patients (11.8%). There was no statistical significance in terms of 5-year EFS and OS among the 3 groups. There was no surgery-related mortality or morbidity. From our center's experience, as there was no substantial survival benefit in stage IV neuroblastoma patients undergoing complete tumor resection, organ preservation and minimalization of morbidity should also be taken into consideration. Copyright © 2015. Published by Elsevier Inc.

Astragaloside IV liposomes ameliorates adriamycin-induced ...

African Journals Online (AJOL)

Methods: The rats were given a single tail intravenous injection of adriamycin (6 mg/kg) within 1 week, and then divided into four groups including normal, model, benazepril and astragaloside IV liposomes group. They were all orally administered dosage of benazepril and astragaloside IV liposomes once daily for 8 weeks.

Diversion Path Analysis handbook. Volume 3 (of 4 volumes). Computer Program 1

International Nuclear Information System (INIS)

Schleter, J.C.

1978-11-01

The FORTRAN IV computer program, DPA Computer Program 1 (DPACP-1), is used to assemble and tabulate the data for Specific Diversion Paths (SDPs) identified when performing a Diversion Path Analysis (DPA) in accord with the methodology given in Volume 1. The program requires 255498 bytes exclusive of the operating system. The data assembled and tabulated by DPACP-1 are used by the DPA team to assist in analyzing vulnerabilities, in a plant's material control and material accounting subsystems, to diversion of special nuclear material (SNM) by a knowledgable insider. Based on this analysis, the DPA team can identify, and propose to plant management, modifications to the plant's safeguards system that would eliminate, or reduce the severity of, the identified vulnerabilities. The data are also used by plant supervision when investigating a potential diversion

Industrial Sector Technology Use Model (ISTUM): industrial energy use in the United States, 1974-2000. Volume 4. Technology appendix. Final Report

Energy Technology Data Exchange (ETDEWEB)

1979-10-01

Volume IV of the ISTUM documentation gives information on the individual technology specifications, but relates closely with Chapter II of Volume I. The emphasis in that chapter is on providing an overview of where each technology fits into the general-model logic. Volume IV presents the actual cost structure and specification of every technology modeled in ISTUM. The first chapter presents a general overview of the ISTUM technology data base. It includes an explanation of the data base printouts and how the separate-cost building blocks are combined to derive an aggregate-technology cost. The remaining chapters are devoted to documenting the specific-technology cost specifications. Technologies included are: conventional technologies (boiler and non-boiler conventional technologies); fossil-energy technologies (atmospheric fluidized bed combustion, low Btu coal and medium Btu coal gasification); cogeneration (steam, machine drive, and electrolytic service sectors); and solar and geothermal technologies (solar steam, solar space heat, and geothermal steam technologies), and conservation technologies.

Uranium enrichment reduction in the Prototype Gen-IV sodium-cooled fast reactor (PGSFR) with PBO reflector

Energy Technology Data Exchange (ETDEWEB)

Hartanto, Donny; Kim, Chi Hyung; Kim, Yong Hee [Dept. of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon (Korea, Republic of)

2016-04-15

The Korean Prototype Gen-IV sodium-cooled fast reactor (PGSFR) is supposed to be loaded with a relatively-costly low-enriched U fuel, while its envisaged transuranic fuels are not available for transmutation. In this work, the U-enrichment reduction by improving the neutron economy is pursued to save the fuel cost. To improve the neutron economy of the core, a new reflector material, PbO, has been introduced to replace the conventional HT9 reflector in the current PGSFR core. Two types of PbO reflectors are considered: one is the conventional pin-type and the other one is an inverted configuration. The inverted PbO reflector design is intended to maximize the PbO volume fraction in the reflector assembly. In addition, the core radial configuration is also modified to maximize the performance of the PbO reflector. For the baseline PGSFR core with several reflector options, the U enrichment requirement has been analyzed and the fuel depletion analysis is performed to derive the equilibrium cycle parameters. The linear reactivity model is used to determine the equilibrium cycle performances of the core. Impacts of the new PbO reflectors are characterized in terms of the cycle length, neutron leakage, radial power distribution, and operational fuel cost.

High cost of stage IV pressure ulcers.

Science.gov (United States)

Brem, Harold; Maggi, Jason; Nierman, David; Rolnitzky, Linda; Bell, David; Rennert, Robert; Golinko, Michael; Yan, Alan; Lyder, Courtney; Vladeck, Bruce

2010-10-01

The aim of this study was to calculate and analyze the cost of treatment for stage IV pressure ulcers. A retrospective chart analysis of patients with stage IV pressure ulcers was conducted. Hospital records and treatment outcomes of these patients were followed up for a maximum of 29 months and analyzed. Costs directly related to the treatment of pressure ulcers and their associated complications were calculated. Nineteen patients with stage IV pressure ulcers (11 hospital-acquired and 8 community-acquired) were identified and their charts were reviewed. The average hospital treatment cost associated with stage IV pressure ulcers and related complications was $129,248 for hospital-acquired ulcers during 1 admission, and $124,327 for community-acquired ulcers over an average of 4 admissions. The costs incurred from stage IV pressure ulcers are much greater than previously estimated. Halting the progression of early stage pressure ulcers has the potential to eradicate enormous pain and suffering, save thousands of lives, and reduce health care expenditures by millions of dollars. Copyright © 2010 Elsevier Inc. All rights reserved.

Data for the screening assessment. Volume 2: Appendices, Columbia River Comprehensive Impact Assessment

International Nuclear Information System (INIS)

Miley, T.B.; O'Neil, T.K.; Gilbert, R.O.; Klevgard, L.A.; Walters, T.B.

1996-06-01

The Columbia River is a critical resource for residents of the Pacific Northwest. This resource drew the Manhattan Project's planners to the site now called Hanford to produce nuclear weapon materials. Production of those materials has left behind a legacy of chemical and radioactive contamination and materials that have, are, and will continue to pose a threat to the Columbia river for the foreseeable future. To evaluate the impact to the river from this Hanford-derived contamination, the US Department of Energy, US Environmental Protection Agency, and State of Washington Department of Ecology (the Tri-Party agencies) initiated a study referred to as the Columbia River Comprehensive Impact Assessment (CRCIA). To address concerns about the scope and direction of CRCIA as well as enhance regulator, stakeholder, tribal, and public involvement, the CRCIA Management Team was formed in August 1995. A major CRCIA Team decision was to organize CRCIA into phases, with additional phases to be identified as warranted after completion of the initial phase. The initial phase is comprised of two parts: (1) a screening assessment to evaluate the current impact to the river resulting from Hanford-derived contamination and (2) identification of requirements considered necessary by the CRCIA Management Team for a comprehensive assessment of impact to the river. The purpose of the screening assessment is to support cleanup decisions. The scope of the screening assessment is to evaluate the current risk to humans and the environment resulting from Hanford-derived contaminants. The screening assessment has the primary components of: identifying contaminants to be assessed; identifying a variety of exposure scenarios to evaluate human contaminant exposure; identifying a variety of other species to evaluate ecological contaminant exposure; and assessing risks posed by exposure of humans and other species to the contaminants. This volume compiles the data from this study

Republic of Korea; Staff Report for the 2015 Article IV Consultation

OpenAIRE

International Monetary Fund

2015-01-01

This 2015 Article IV Consultation highlights that Korea’s growth momentum that had been building since early 2013 has stalled. Average quarterly growth rate declined to about 0.5 percent in the last three quarters of 2014 from about 1 percent in the previous four quarters. A turning point was the April 2014 Sewol ferry accident, which had a surprisingly large and persistent impact on consumer and investor sentiment. Growth is projected to be in a range centered about 3 percent in 2015. The ma...

Limited impacts of truck-based ultra-low-volume applications of mosquito adulticides on mortality in honey bees (Apis mellifera).

Science.gov (United States)

Rinkevich, F D; Margotta, J W; Pokhrel, V; Walker, T W; Vaeth, R H; Hoffman, W C; Fritz, B K; Danka, R G; Rinderer, T E; Aldridge, R L; Linthicum, K J; Ottea, J A; Healy, K B

2017-12-01

Adulticides applied against mosquitoes can reduce vector populations during times of high arbovirus transmission. However, impacts of these insecticides on pollinators and other non-target organisms are of concern to mosquito control professionals, beekeepers and others. We evaluated mortality of Culex quinquefasciatus and Apis mellifera when caged insects were exposed to low and high label rates of four common adulticides (Aqua-Pursuit™ [permethrin], Duet® [prallethrin + sumithrin], Fyfanon® [malathion] and Scourge® [resmethrin]) at six distances up to 91.4 m from a truck-mounted ultra-low-volume sprayer. Honey bee mortality was both absolutely low (61 m had limited impacts on honey bee mortality while providing effective mosquito control.

Draft Waste Management Programmatic Environmental Impact Statement for managing treatment, storage, and disposal of radioactive and hazardous waste. Volume 3, Appendix A: Public response to revised NOI, Appendix B: Environmental restoration, Appendix C, Environmental impact analysis methods, Appendix D, Risk

International Nuclear Information System (INIS)

1995-08-01

Volume three contains appendices for the following: Public comments do DOE's proposed revisions to the scope of the waste management programmatic environmental impact statement; Environmental restoration sensitivity analysis; Environmental impacts analysis methods; and Waste management facility human health risk estimates

Draft Waste Management Programmatic Environmental Impact Statement for managing treatment, storage, and disposal of radioactive and hazardous waste. Volume 3, Appendix A: Public response to revised NOI, Appendix B: Environmental restoration, Appendix C, Environmental impact analysis methods, Appendix D, Risk

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-08-01

Volume three contains appendices for the following: Public comments do DOE`s proposed revisions to the scope of the waste management programmatic environmental impact statement; Environmental restoration sensitivity analysis; Environmental impacts analysis methods; and Waste management facility human health risk estimates.

Possible impact of the standardized Category IV regimen on multidrug-resistant tuberculosis patients in Mumbai.

Science.gov (United States)

Udwadia, Zarir F; Mullerpattan, Jai Bharat; Shah, Kushal D; Rodrigues, Camilla S

2016-01-01

Treatment of multidrug-resistant tuberculosis (MDR-TB) in the Programmatic Management of Drug-resistant TB program involves a standard regimen with a 6-month intensive phase and an 18-month continuation phase. However, the local drug resistance patterns in high MDR regions such as Mumbai may not be adequately reflected in the design of the regimen for that particular area. The study was carried out at a private Tertiary Level Hospital in Mumbai in a mycobacteriology laboratory equipped to perform the second-line drug susceptibility testing (DST). We attempted to analyze the impact of prescribing the standardized Category IV regimen to all patients receiving a DST at our mycobacteriology laboratory. All samples confirmed to be MDR-TB and tested for the second-line drugs at Hinduja Hospital's Mycobacteriology Laboratory in the year 2012 were analyzed. A total of 1539 samples were analyzed. Of these, 464 (30.14%) were MDR-TB, 867 (56.33%) were MDR with fluoroquinolone resistance, and 198 (12.8%) were extensively drug-resistant TB. The average number of susceptible drugs per sample was 3.07 ± 1.29 (assuming 100% cycloserine susceptibility). Taking 4 effective drugs to be the cut or an effective regimen, the number of patients receiving 4 or more effective drugs from the standardized directly observed treatment, short-course plus regimen would be 516 (33.5%) while 66.5% of cases would receive 3 or less effective drugs. Our study shows that a high proportion of patients will have resistance to a number of the first- and second-line drugs. Local epidemiology must be factored in to avoid amplification of resistance.

Group IV nanotube transistors for next generation ubiquitous computing

KAUST Repository

Fahad, Hossain M.

2014-06-04

Evolution in transistor technology from increasingly large power consuming single gate planar devices to energy efficient multiple gate non-planar ultra-narrow (< 20 nm) fins has enhanced the scaling trend to facilitate doubling performance. However, this performance gain happens at the expense of arraying multiple devices (fins) per operation bit, due to their ultra-narrow dimensions (width) originated limited number of charges to induce appreciable amount of drive current. Additionally arraying degrades device off-state leakage and increases short channel characteristics, resulting in reduced chip level energy-efficiency. In this paper, a novel nanotube device (NTFET) topology based on conventional group IV (Si, SiGe) channel materials is discussed. This device utilizes a core/shell dual gate strategy to capitalize on the volume-inversion properties of an ultra-thin (< 10 nm) group IV nanotube channel to minimize leakage and short channel effects while maximizing performance in an area-efficient manner. It is also shown that the NTFET is capable of providing a higher output drive performance per unit chip area than an array of gate-all-around nanowires, while maintaining the leakage and short channel characteristics similar to that of a single gate-all-around nanowire, the latter being the most superior in terms of electrostatic gate control. In the age of big data and the multitude of devices contributing to the internet of things, the NTFET offers a new transistor topology alternative with maximum benefits from performance-energy efficiency-functionality perspective. © (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

Analysis of a Spanish energy scenario with Generation IV nuclear reactors

International Nuclear Information System (INIS)

Ochoa, Raquel; Jimenez, Gonzalo; Perez-Martin, Sara

2013-01-01

Highlights: • Spanish energy scenario for the hypothetical deployment of Gen-IV SFR reactors. • Availability of national resources is assessed, considering SFR’s breeding. • An assessment of the impact of transmuting MA on the final repository. • SERPENT code with own pre- and post-processing tools were employed. • The employed SFR core design is based on the specifications of the CP-ESFR. - Abstract: The advantages of fast-spectrum reactors consist not only of an efficient use of fuel through the breeding of fissile material and the use of natural or depleted uranium, but also of the potential reduction of the amount of actinides such as americium and neptunium contained in the irradiated fuel. The first aspect means a guaranteed future nuclear fuel supply. The second fact is key for high-level radioactive waste management, because these elements are the main responsible for the radioactivity of the irradiated fuel in the long term. The present study aims to analyze the hypothetical deployment of a Gen-IV Sodium Fast Reactor (SFR) fleet in Spain. A nuclear fleet of fast reactors would enable a fuel cycle strategy different than the open cycle, currently adopted by most of the countries with nuclear power. A transition from the current Gen-II to Gen-IV fleet is envisaged through an intermediate deployment of Gen-III reactors. Fuel reprocessing from the Gen-II and Gen-III Light Water Reactors (LWR) has been considered. In the so-called advanced fuel cycle, the reprocessed fuel used to produce energy will breed new fissile fuel and transmute minor actinides at the same time. A reference case scenario has been postulated and further sensitivity studies have been performed to analyze the impact of the different parameters on the required reactor fleet. The potential capability of Spain to supply the required fleet for the reference scenario using national resources has been verified. Finally, some consequences on irradiated final fuel inventory are assessed

Final waste management programmatic environmental impact statement for managing treatment, storage, and disposl of radioactive and hazardous waste. Volume II

International Nuclear Information System (INIS)

1997-01-01

The Final Waste Management Programmatic Environmental Impact Statement (WM PEIS) examines the potential environmental and cost impacts of strategic management alternatives for managing five types of radioactive and hazardous wastes that have resulted and will continue to result from nuclear defense and research activities at a variety of sites around the United States. The five waste types are low-level mixed waste, low-level waste, transuranic waste, high-level waste, and hazardous waste. The WM PEIS provides information on the impacts of various siting alternatives which the Department of Energy (DOE) will use to decide at which sites to locate additional treatment, storage, and disposal capacity for each waste type.Volume II is an integral part of the Office of Environmental Management''s (EM''s) Waste Management Programmatic Environmental Impact Statement (WM PEIS), which portrays the impacts of EM''s waste management activities at each of the 17 major DOE sites evaluated in the WM PEIS

Expression and enzymatic activity of dipeptidyl peptidase-IV in human astrocytic tumours are associated with tumour grade

Czech Academy of Sciences Publication Activity Database

Stremeňová, J.; Křepela, E.; Mareš, Vladislav; Trim, J.; Dbalý, V.; Marek, J.; Vaníčková, Z.; Lisá, Věra; Yea, Ch.; Šedo, A.

2007-01-01

Roč. 31, č. 4 (2007), s. 785-792 ISSN 1019-6439 R&D Projects: GA MZd NR8105 Institutional research plan: CEZ:AV0Z50110509 Keywords : Dipeptidyl peptidase-IV * human brain tumors * DASH molecules Subject RIV: FD - Oncology ; Hematology Impact factor: 2.295, year: 2007

Painlevé IV coherent states

Energy Technology Data Exchange (ETDEWEB)

Bermudez, David, E-mail: david.bermudez@weizmann.ac.il [Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100 (Israel); Departamento de Física, Cinvestav, A.P. 14-740, 07000 México D.F. (Mexico); Contreras-Astorga, Alonso, E-mail: aloncont@iun.edu [Department of Mathematics and Actuarial Science, Indiana University Northwest, 3400 Broadway, Gary IN 46408 (United States); Departamento de Física, Cinvestav, A.P. 14-740, 07000 México D.F. (Mexico); Fernández C, David J., E-mail: david@fis.cinvestav.mx [Departamento de Física, Cinvestav, A.P. 14-740, 07000 México D.F. (Mexico)

2014-11-15

A simple way to find solutions of the Painlevé IV equation is by identifying Hamiltonian systems with third-order differential ladder operators. Some of these systems can be obtained by applying supersymmetric quantum mechanics (SUSY QM) to the harmonic oscillator. In this work, we will construct families of coherent states for such subset of SUSY partner Hamiltonians which are connected with the Painlevé IV equation. First, these coherent states are built up as eigenstates of the annihilation operator, then as displaced versions of the extremal states, both involving the related third-order ladder operators, and finally as extremal states which are also displaced but now using the so called linearized ladder operators. To each SUSY partner Hamiltonian corresponds two families of coherent states: one inside the infinite subspace associated with the isospectral part of the spectrum and another one in the finite subspace generated by the states created through the SUSY technique. - Highlights: • We use SUSY QM to obtain Hamiltonians with third-order differential ladder operators. • We show that these systems are related with the Painlevé IV equation. • We apply different definitions of coherent states to these Hamiltonians using the third-order ladder operators and some linearized ones. • We construct families of coherent states for such systems, which we called Painlevé IV coherent states.

Painlevé IV coherent states

International Nuclear Information System (INIS)

Bermudez, David; Contreras-Astorga, Alonso; Fernández C, David J.

2014-01-01

A simple way to find solutions of the Painlevé IV equation is by identifying Hamiltonian systems with third-order differential ladder operators. Some of these systems can be obtained by applying supersymmetric quantum mechanics (SUSY QM) to the harmonic oscillator. In this work, we will construct families of coherent states for such subset of SUSY partner Hamiltonians which are connected with the Painlevé IV equation. First, these coherent states are built up as eigenstates of the annihilation operator, then as displaced versions of the extremal states, both involving the related third-order ladder operators, and finally as extremal states which are also displaced but now using the so called linearized ladder operators. To each SUSY partner Hamiltonian corresponds two families of coherent states: one inside the infinite subspace associated with the isospectral part of the spectrum and another one in the finite subspace generated by the states created through the SUSY technique. - Highlights: • We use SUSY QM to obtain Hamiltonians with third-order differential ladder operators. • We show that these systems are related with the Painlevé IV equation. • We apply different definitions of coherent states to these Hamiltonians using the third-order ladder operators and some linearized ones. • We construct families of coherent states for such systems, which we called Painlevé IV coherent states

Impact of TBI on late effects in children treated by megatherapy for Stage IV neuroblastoma. A study of the French Society of Pediatric oncology

International Nuclear Information System (INIS)

Flandin, Isabelle; Hartmann, Olivier; Michon, Jean; Pinkerton, Ross; Coze, Carole; Stephan, Jean Louis; Fourquet, Bernard; Valteau-Couanet, Dominique; Bergeron, Christophe; Philip, Thierry; Carrie, Christian

2006-01-01

Purpose: To determine the contribution of total body irradiation (TBI) to late sequelae in children treated with high-dose chemotherapy and autologous bone marrow transplantation for Stage IV neuroblastoma. Patients and Methods: We compared two populations that were similar with regard to age, stage, pre-autologous bone marrow transplantation chemotherapy (CT) regimen, period of treatment, and follow-up (12 years). The TBI group (n = 32) received TBI as part of the megatherapy procedure (1982-1993), whereas the CT group (n 30) received conditioning without TBI (1985-1992). Analysis 12 years later focused on growth, weight and corpulence (body mass index) delay; hormonal deficiencies; liver, kidney, heart, ear, eye, and dental sequelae; school performance; and the incidence of secondary tumors. Results: Impact of TBI was most marked in relation to growth and weight delay, although the mean delay was not severe, probably because of treatment with growth hormones. Other consequences of TBI were thyroid insufficiency, cataracts, and a high incidence of secondary tumors. Hearing loss and dental agenesis were more prominent in the group treated with CT alone. No differences were observed in school performance. Conclusion: The most frequent side effects of TBI were cataracts, thyroid insufficiency, and growth delay, but more worrying is the risk of secondary tumors. Because of the young mean age of patients and the toxicity of TBI regimens without any survival advantage, regimens without TBI are preferable in the management of Stage IV neuroblastoma

Gulf of Mexico Sales 139 and 141: Central and western planning areas. Final environmental impact statement. Volume 1: Sections 1 through 4.C. Final report

International Nuclear Information System (INIS)

1991-10-01

The report is Volume I of two volumes. The EIS is a description of the environmental aspects and impacts of oil and gas activities resulting from these lease sales or the States bordering the Gulf of Mexico. It provides a description of the areas, the affected environment, and the environmental consequences; it describes the proposed actions, issues and areas of concern, and the major differences of holding these lease sales

Synthesis, characterization and thermal behaviour of cadmium (II) complexes of photosubstituted octacyano-molybdate(IV) and -tungstate(IV) with ethylenediamine

International Nuclear Information System (INIS)

Ali, S.I.; Majid, Kowsar

1998-01-01

Photosubstituted ethylenediamine complexes of M(CN) 8 4- [where M =Mo(IV) or W(IV)] with cadmium (II) chloride have been synthesized and characterized by infrared (IR), thermogravimetric (TG) and differential scanning calorimetry (DSC). Both Mo(IV) and W(IV) show similar stoichiometric as well as thermal decomposition behaviour. The assigned general formula is Cd[M(CN) 3 (OH)(C 2 H 8 N 2 ) 2 ](C 2 H 8 N 2 ) Cl 2 XH 2 O [where M = Mo(IV) for which X = 1(I) and M = W(IV) for which X = 2 (II)]. The presence of CN - , OH - and C 2 H 8 N 2 has been shown by observed characteristic IR peaks. The extra absorption bands appearing in complex (II) are due to librational modes of water which show the formation of hydrogen bonding, which is also supported by TG analysis. The loss of these absorption bands rules out this type of bonding in (I). Both the complexes decompose in three steps up to 650 degC after which there is no change. DSC of the complexes also shows three transitions, two exothermic and one endothermic. On the basis of TG and DSC thermograms, mechanism for the decomposition of each step has been shown. Kinetic parameters like activation energy (E a ), frequency factor (A) and entropy of activation (ΔS) have been calculated using different integral methods. (author)

Nordic Nuclear Materials Forum for Generation IV Reactors

Energy Technology Data Exchange (ETDEWEB)

Anghel, C. (Studsvik Nuclear AB, Nykoeping (Sweden)); Penttilae, S. (Technical Research Centre of Finland, VTT (Finland))

2010-03-15

A network for material issues for Generation IV nuclear power has been initiated within the Nordic countries. The objectives of the Generation IV Nordic Nuclear Materials Forum (NOMAGE4) are to put the basis of a sustainable forum for Gen IV issues, especially focussing on fuels, cladding, structural materials and coolant interaction. Other issues include reactor physics, dynamics and diagnostics, core and fuel design. The present report summarizes the work performed during the year 2009. The efforts made include identification of organisations involved in Gen IV issues in the Nordic countries, update of the forum website, http://www.studsvik.se/GenerationIV, and investigation of capabilities for research within the area of Gen IV. Within the NOMAGE4 project a seminar on Generation IV Nuclear Energy Systems has been organized during 15-16th of October 2009. The aim of the seminar was to provide a forum for exchange of information, discussion on future research needs and networking of experts on Generation IV reactor concepts. As an outcome of the NOMAGE4, a few collaboration project proposals have been prepared/planned in 2009. The network was welcomed by the European Commission and was mentioned as an exemplary network with representatives from industries, universities, power companies and research institutes. NOMAGE4 has been invited to participate to the 'European Energy Research Alliance, EERA, workshop for nuclear structural materials' http://www.eera-set.eu/index.php?index=41 as external observers. Future plans include a new Nordic application for continuation of NOMAGE4 network. (author)

Nordic Nuclear Materials Forum for Generation IV Reactors

International Nuclear Information System (INIS)

Anghel, C.; Penttilae, S.

2010-03-01

A network for material issues for Generation IV nuclear power has been initiated within the Nordic countries. The objectives of the Generation IV Nordic Nuclear Materials Forum (NOMAGE4) are to put the basis of a sustainable forum for Gen IV issues, especially focussing on fuels, cladding, structural materials and coolant interaction. Other issues include reactor physics, dynamics and diagnostics, core and fuel design. The present report summarizes the work performed during the year 2009. The efforts made include identification of organisations involved in Gen IV issues in the Nordic countries, update of the forum website, http://www.studsvik.se/GenerationIV, and investigation of capabilities for research within the area of Gen IV. Within the NOMAGE4 project a seminar on Generation IV Nuclear Energy Systems has been organized during 15-16th of October 2009. The aim of the seminar was to provide a forum for exchange of information, discussion on future research needs and networking of experts on Generation IV reactor concepts. As an outcome of the NOMAGE4, a few collaboration project proposals have been prepared/planned in 2009. The network was welcomed by the European Commission and was mentioned as an exemplary network with representatives from industries, universities, power companies and research institutes. NOMAGE4 has been invited to participate to the 'European Energy Research Alliance, EERA, workshop for nuclear structural materials' http://www.eera-set.eu/index.php?index=41 as external observers. Future plans include a new Nordic application for continuation of NOMAGE4 network. (author)

Impact of retinal pigment epithelium pathology on spectral-domain optical coherence tomography-derived macular thickness and volume metrics and their intersession repeatability.

Science.gov (United States)

Hanumunthadu, Daren; Wang, Jin Ping; Chen, Wei; Wong, Evan N; Chen, Yi; Morgan, William H; Patel, Praveen J; Chen, Fred K

2017-04-01

To determine the impact of retinal pigment epithelium (RPE) pathology on intersession repeatability of retinal thickness and volume metrics derived from Spectralis spectral-domain optical coherence tomography (Heidelberg Engineering, Heidelberg, Germany). Prospective cross-sectional single centre study. A total of 56 eyes of 56 subjects were divided into three groups: (i) normal RPE band (25 eyes); (ii) RPE elevation: macular soft drusen (13 eyes); and (iii) RPE attenuation: geographic atrophy or inherited retinal diseases (18 eyes). Each subject underwent three consecutive follow-up macular raster scans (61 B-scans at 119 μm separation) at 1-month intervals. Retinal thicknesses and volumes for each zone of the macular subfields before and after manual correction of segmentation error. Coefficients of repeatability (CR) were calculated. Mean (range) age was 57 (21-88) years. Mean central subfield thickness (CST) and total macular volume were 264 and 258 μm (P = 0.62), and 8.0 and 7.8 mm 3 (P = 0.31), before and after manual correction. Intersession CR (95% confidence interval) for CST and total macular volume were reduced from 40 (38-41) to 8.3 (8.1-8.5) and 0.62 to 0.16 mm 3 after manual correction of segmentation lines. CR for CST were 7.4, 23.5 and 66.7 μm before and 7.0, 10.9 and 7.6 μm after manual correction in groups i, ii and iii. Segmentation error in eyes with RPE disease has a significant impact on intersession repeatability of Spectralis spectral-domain optical coherence tomography macular thickness and volume metrics. Careful examination of each B-scan and manual adjustment can enhance the utility of quantitative measurement. Improved automated segmentation algorithms are needed. © 2016 Royal Australian and New Zealand College of Ophthalmologists.

A COMPARATIVE CLINICAL STUDY BETWEEN IV ESMOLOL AND IV FENTANYL ON ATTENUATION OF HAEMODYNAMIC RESPONSES TO LARYNGOSCOPY AND INTUBATION

Directory of Open Access Journals (Sweden)

Abu Lais Mustaque

2016-04-01

Full Text Available INTRODUCTION Laryngoscopy and intubation is an integral part for providing general anaesthesia to patients undergoing various types of surgery. It also plays an important role in critical care units viz. for providing mechanical ventilation. It is a very essential tool in the hands of anaesthesiologist in maintaining airway. The present study is undertaken to determine and compare the efficacy of single bolus dose of IV esmolol 1 mg/kg and IV fentanyl 2 mcg/kg in attenuating the haemodynamic responses to laryngoscopy and tracheal intubation and to ascertain the effectiveness of esmolol hydrochloride and fentanyl citrate in suppressing sympathetic responses. MATERIAL & METHODS The study was conducted under the Department of Anaesthesiology and Critical Care, Assam Medical College and Hospital, Dibrugarh, during the period July 2013 to June 2014. For this purpose, 150 patients of either sex between 20-50 years of ASA I & II physical status were selected after obtaining informed and written consent and were divided into two groups namely, Group E receiving IV esmolol (1 mg/kg and Group F receiving IV fentanyl (2 mcg/kg. RESULTS Inj. fentanyl 2 mcg/kg IV administered 5 minutes before laryngoscopy and intubation was able to prevent adverse haemodynamic changes better than Inj. esmolol 1 mg/kg IV administered 3 minutes prior to laryngoscopy and intubation during elective surgeries under general anaesthesia. CONCLUSION Hence, from the findings of this study we can conclude that IV bolus dose of fentanyl 2 mcg/kg administered 5 minutes before laryngoscopy and intubation can attenuate the sympathetic response to laryngoscopy and intubation without any side effects of the drug in healthy patients undergoing elective surgeries under general anaesthesia.

ILC Reference Design Report Volume 4 - Detectors

CERN Document Server

Behnke, Ties; Jaros, John; Miyamoto, Akiya; Aarons, Gerald; Abe, Toshinori; Abernathy, Jason; Ablikim, Medina; Abramowicz, Halina; Adey, David; Adloff, Catherine; Adolphsen, Chris; Afanaciev, Konstantin; Agapov, Ilya; Ahn, Jung-Keun; Aihara, Hiroaki; Akemoto, Mitsuo; del Carmen Alabau, Maria; Albert, Justin; Albrecht, Hartwig; Albrecht, Michael; Alesini, David; Alexander, Gideon; Alexander, Jim; Allison, Wade; Amann, John; Amirikas, Ramila; An, Qi; Anami, Shozo; Ananthanarayan, B.; Anderson, Terry; Andricek, Ladislav; Anduze, Marc; Anerella, Michael; Anfimov, Nikolai; Angal-Kalinin, Deepa; Antipov, Sergei; Antoine, Claire; Aoki, Mayumi; Aoza, Atsushi; Aplin, Steve; Appleby, Rob; Arai, Yasuo; Araki, Sakae; Arkan, Tug; Arnold, Ned; Arnold, Ray; Arnowitt, Richard; Artru, Xavier; Arya, Kunal; Aryshev, Alexander; Asakawa, Eri; Asiri, Fred; Asner, David; Atac, Muzaffer; Atoian, Grigor; Attié, David; Augustin, Jean-Eudes; Augustine, David B.; Ayres, Bradley; Aziz, Tariq; Baars, Derek; Badaud, Frederique; Baddams, Nigel; Bagger, Jonathan; Bai, Sha; Bailey, David; Bailey, Ian R.; Baker, David; Balalykin, Nikolai I.; Balbuena, Juan Pablo; Baldy, Jean-Luc; Ball, Markus; Ball, Maurice; Ballestrero, Alessandro; Ballin, Jamie; Baltay, Charles; Bambade, Philip; Ban, Syuichi; Band, Henry; Bane, Karl; Banerjee, Bakul; Barbanotti, Serena; Barbareschi, Daniele; Barbaro-Galtieri, Angela; Barber, Desmond P.; Barbi, Mauricio; Bardin, Dmitri Y.; Barish, Barry; Barklow, Timothy L.; Barlow, Roger; Barnes, Virgil E.; Barone, Maura; Bartels, Christoph; Bartsch, Valeria; Basu, Rahul; Battaglia, Marco; Batygin, Yuri; Baudot, Jerome; Baur, Ulrich; Elwyn Baynham, D.; Beard, Carl; Bebek, Chris; Bechtle, Philip; Becker, Ulrich J.; Bedeschi, Franco; Bedjidian, Marc; Behera, Prafulla; Bellantoni, Leo; Bellerive, Alain; Bellomo, Paul; Bentson, Lynn D.; Benyamna, Mustapha; Bergauer, Thomas; Berger, Edmond; Bergholz, Matthias; Beri, Suman; Berndt, Martin; Bernreuther, Werner; Bertolini, Alessandro; Besancon, Marc; Besson, Auguste; Beteille, Andre; Bettoni, Simona; Beyer, Michael; Bhandari, R.K.; Bharadwaj, Vinod; Bhatnagar, Vipin; Bhattacharya, Satyaki; Bhattacharyya, Gautam; Bhattacherjee, Biplob; Bhuyan, Ruchika; Bi, Xiao-Jun; Biagini, Marica; Bialowons, Wilhelm; Biebel, Otmar; Bieler, Thomas; Bierwagen, John; Birch, Alison; Bisset, Mike; Biswal, S.S.; Blackmore, Victoria; Blair, Grahame; Blanchard, Guillaume; Blazey, Gerald; Blue, Andrew; Blümlein, Johannes; Boffo, Christian; Bohn, Courtlandt; Boiko, V.I.; Boisvert, Veronique; Bondarchuk, Eduard N.; Boni, Roberto; Bonvicini, Giovanni; Boogert, Stewart; Boonekamp, Maarten; Boorman, Gary; Borras, Kerstin; Bortoletto, Daniela; Bosco, Alessio; Bosio, Carlo; Bosland, Pierre; Bosotti, Angelo; Boudry, Vincent; Boumediene, Djamel-Eddine; Bouquet, Bernard; Bourov, Serguei; Bowden, Gordon; Bower, Gary; Boyarski, Adam; Bozovic-Jelisavcic, Ivanka; Bozzi, Concezio; Brachmann, Axel; Bradshaw, Tom W.; Brandt, Andrew; Brasser, Hans Peter; Brau, Benjamin; Brau, James E.; Breidenbach, Martin; Bricker, Steve; Brient, Jean-Claude; Brock, Ian; Brodsky, Stanley; Brooksby, Craig; Broome, Timothy A.; Brown, David; Brown, David; Brownell, James H.; Bruchon, Mélanie; Brueck, Heiner; Brummitt, Amanda J.; Brun, Nicole; Buchholz, Peter; Budagov, Yulian A.; Bulgheroni, Antonio; Bulyak, Eugene; Bungau, Adriana; Bürger, Jochen; Burke, Dan; Burkhart, Craig; Burrows, Philip; Burt, Graeme; Burton, David; Büsser, Karsten; Butler, John; Butterworth, Jonathan; Buzulutskov, Alexei; Cabruja, Enric; Caccia, Massimo; Cai, Yunhai; Calcaterra, Alessandro; Caliier, Stephane; Camporesi, Tiziano; Cao, Jun-Jie; Cao, J.S.; Capatina, Ofelia; Cappellini, Chiara; Carcagno, Ruben; Carena, Marcela; Carloganu, Cristina; Carosi, Roberto; Stephen Carr, F.; Carrion, Francisco; Carter, Harry F.; Carter, John; Carwardine, John; Cassel, Richard; Cassell, Ronald; Cavallari, Giorgio; Cavallo, Emanuela; Cembranos, Jose A.R.; Chakraborty, Dhiman; Chandez, Frederic; Charles, Matthew; Chase, Brian; Chattopadhyay, Subhasis; Chauveau, Jacques; Chefdeville, Maximilien; Chehab, Robert; Chel, Stéphane; Chelkov, Georgy; Chen, Chiping; Chen, He Sheng; Chen, Huai Bi; Chen, Jia Er; Chen, Sen Yu; Chen, Shaomin; Chen, Shenjian; Chen, Xun; Chen, Yuan Bo; Cheng, Jian; Chevallier, M.; Chi, Yun Long; Chickering, William; Cho, Gi-Chol; Cho, Moo-Hyun; Choi, Jin-Hyuk; Choi, Jong Bum; Choi, Seong Youl; Choi, Young-Il; Choudhary, Brajesh; Choudhury, Debajyoti; Rai Choudhury, S.; Christian, David; Christian, Glenn; Christophe, Grojean; Chung, Jin-Hyuk; Church, Mike; Ciborowski, Jacek; Cihangir, Selcuk; Ciovati, Gianluigi; Clarke, Christine; Clarke, Don G.; Clarke, James A.; Clements, Elizabeth; Coca, Cornelia; Coe, Paul; Cogan, John; Colas, Paul; Collard, Caroline; Colledani, Claude; Combaret, Christophe; Comerma, Albert; Compton, Chris; Constance, Ben; Conway, John; Cook, Ed; Cooke, Peter; Cooper, William; Corcoran, Sean; Cornat, Rémi; Corner, Laura; Cortina Gil, Eduardo; Clay Corvin, W.; Cotta Ramusino, Angelo; Cowan, Ray; Crawford, Curtis; Cremaldi, Lucien M; Crittenden, James A.; Cussans, David; Cvach, Jaroslav; da Silva, Wilfrid; Dabiri Khah, Hamid; Dabrowski, Anne; Dabrowski, Wladyslaw; Dadoun, Olivier; Dai, Jian Ping; Dainton, John; Daly, Colin; Danilov, Mikhail; Daniluk, Witold; Daram, Sarojini; Datta, Anindya; Dauncey, Paul; David, Jacques; Davier, Michel; Davies, Ken P.; Dawson, Sally; De Boer, Wim; De Curtis, Stefania; De Groot, Nicolo; de la Taille, Christophe; de Lira, Antonio; De Roeck, Albert; de Sangro, Riccardo; De Santis,Stefano; Deacon, Laurence; Deandrea, Aldo; Dehmelt, Klaus; Delagnes, Eric; Delahaye, Jean-Pierre; Delebecque, Pierre; Delerue, Nicholas; Delferriere, Olivier; Demarteau, Marcel; Deng, Zhi; Denisov, Yu.N.; Densham, Christopher J.; Desch, Klaus; Deshpande, Nilendra; Devanz, Guillaume; Devetak, Erik; Dexter, Amos; Di benedetto, Vito; Diéguez, Angel; Diener, Ralf; Dinh, Nguyen Dinh; Dixit, Madhu; Dixit, Sudhir; Djouadi, Abdelhak; Dolezal, Zdenek; Dollan, Ralph; Dong, Dong; Dong, Hai Yi; Dorfan, Jonathan; Dorokhov, Andrei; Doucas, George; Downing, Robert; Doyle, Eric; Doziere, Guy; Drago, Alessandro; Dragt, Alex; Drake, Gary; Drásal, Zbynek; Dreiner, Herbert; Drell, Persis; Driouichi, Chafik; Drozhdin, Alexandr; Drugakov, Vladimir; Du, Shuxian; Dugan, Gerald; Duginov, Viktor; Dulinski, Wojciech; Dulucq, Frederic; Dutta, Sukanta; Dwivedi, Jishnu; Dychkant, Alexandre; Dzahini, Daniel; Eckerlin, Guenter; Edwards, Helen; Ehrenfeld, Wolfgang; Ehrlichman, Michael; Ehrlichmann, Heiko; Eigen, Gerald; Elagin, Andrey; Elementi, Luciano; Eliasson, Peder; Ellis, John; Ellwood, George; Elsen, Eckhard; Emery, Louis; Enami, Kazuhiro; Endo, Kuninori; Enomoto, Atsushi; Eozénou, Fabien; Erbacher, Robin; Erickson, Roger; Oleg Eyser, K.; Fadeyev, Vitaliy; Fang, Shou Xian; Fant, Karen; Fasso, Alberto; Faucci Giannelli, Michele; Fehlberg, John; Feld, Lutz; Feng, Jonathan L.; Ferguson, John; Fernandez-Garcia, Marcos; Luis Fernandez-Hernando, J.; Fiala, Pavel; Fieguth, Ted; Finch, Alexander; Finocchiaro, Giuseppe; Fischer, Peter; Fisher, Peter; Eugene Fisk, H.; Fitton, Mike D.; Fleck, Ivor; Fleischer, Manfred; Fleury, Julien; Flood, Kevin; Foley, Mike; Ford, Richard; Fortin, Dominique; Foster, Brian; Fourches, Nicolas; Francis, Kurt; Frey, Ariane; Frey, Raymond; Friedsam, Horst; Frisch, Josef; Frishman, Anatoli; Fuerst, Joel; Fujii, Keisuke; Fujimoto, Junpei; Fukuda, Masafumi; Fukuda, Shigeki; Funahashi, Yoshisato; Funk, Warren; Furletova, Julia; Furukawa, Kazuro; Furuta, Fumio; Fusayasu, Takahiro; Fuster, Juan; Gadow, Karsten; Gaede, Frank; Gaglione, Renaud; Gai, Wei; Gajewski, Jan; Galik, Richard; Galkin, Alexei; Galkin, Valery; Gallin-Martel, Laurent; Gannaway, Fred; Gao, Jian She; Gao, Jie; Gao, Yuanning; Garbincius, Peter; Garcia-Tabares, Luis; Garren, Lynn; Garrido, Luís; Garutti, Erika; Garvey, Terry; Garwin, Edward; Gascón, David; Gastal, Martin; Gatto, Corrado; Gatto, Raoul; Gay, Pascal; Ge, Lixin; Ge, Ming Qi; Ge, Rui; Geiser, Achim; Gellrich, Andreas; Genat, Jean-Francois; Geng, Zhe Qiao; Gentile, Simonetta; Gerbick, Scot; Gerig, Rod; Ghosh, Dilip Kumar; Ghosh, Kirtiman; Gibbons, Lawrence; Giganon, Arnaud; Gillespie, Allan; Gillman, Tony; Ginzburg, Ilya; Giomataris, Ioannis; Giunta, Michele; Gladkikh, Peter; Gluza, Janusz; Godbole, Rohini; Godfrey, Stephen; Goldhaber, Gerson; Goldstein, Joel; Gollin, George D.; Gonzalez-Sanchez, Francisco Javier; Goodrick, Maurice; Gornushkin, Yuri; Gostkin, Mikhail; Gottschalk, Erik; Goudket, Philippe; Gough Eschrich, Ivo; Gournaris, Filimon; Graciani, Ricardo; Graf, Norman; Grah, Christian; Grancagnolo, Francesco; Grandjean, Damien; Grannis, Paul; Grassellino, Anna; Graugés, Eugeni; Gray, Stephen; Green, Michael; Greenhalgh, Justin; Greenshaw, Timothy; Grefe, Christian; Gregor, Ingrid-Maria; Grenier, Gerald; Grimes, Mark; Grimm, Terry; Gris, Philippe; Grivaz, Jean-Francois; Groll, Marius; Gronberg, Jeffrey; Grondin, Denis; Groom, Donald; Gross, Eilam; Grunewald, Martin; Grupen, Claus; Grzelak, Grzegorz; Gu, Jun; Gu, Yun-Ting; Guchait, Monoranjan; Guiducci, Susanna; Guler, Ali Murat; Guler, Hayg; Gulmez, Erhan; Gunion, John; Guo, Zhi Yu; Gurtu, Atul; Ha, Huy Bang; Haas, Tobias; Haase, Andy; Haba, Naoyuki; Haber, Howard; Haensel, Stephan; Hagge, Lars; Hagura, Hiroyuki; Hajdu, Csaba; Haller, Gunther; Haller, Johannes; Hallermann, Lea; Halyo, Valerie; Hamaguchi, Koichi; Hammond, Larry; Han, Liang; Han, Tao; Hand, Louis; Handu, Virender K.; Hano, Hitoshi; Hansen, Christian; Hansen, Jørn Dines; Hansen, Jorgen Beck; Hara, Kazufumi; Harder, Kristian; Hartin, Anthony; Hartung, Walter; Hast, Carsten; Hauptman, John; Hauschild, Michael; Hauviller, Claude; Havranek, Miroslav; Hawkes, Chris; Hawkings, Richard; Hayano, Hitoshi; Hazumi, Masashi; He, An; He, Hong Jian; Hearty, Christopher; Heath, Helen; Hebbeker, Thomas; Hedberg, Vincent; Hedin, David; Heifets, Samuel; Heinemeyer, Sven; Heini, Sebastien; Helebrant, Christian; Helms, Richard; Heltsley, Brian; Henrot-Versille, Sophie; Henschel, Hans; Hensel, Carsten; Hermel, Richard; Herms, Atilà; Herten, Gregor; Hesselbach, Stefan; Heuer, Rolf-Dieter; Heusch, Clemens A.; Hewett, Joanne; Higashi, Norio; Higashi, Takatoshi; Higashi, Yasuo; Higo, Toshiyasu; Hildreth, Michael D.; Hiller, Karlheinz; Hillert, Sonja; Hillier, Stephen James; Himel, Thomas; Himmi, Abdelkader; Hinchliffe, Ian; Hioki, Zenro; Hirano, Koichiro; Hirose, Tachishige; Hisamatsu, Hiromi; Hisano, Junji; Hlaing, Chit Thu; Hock, Kai Meng; Hoeferkamp, Martin; Hohlfeld, Mark; Honda, Yousuke; Hong, Juho; Hong, Tae Min; Honma, Hiroyuki; Horii, Yasuyuki; Horvath, Dezso; Hosoyama, Kenji; Hostachy, Jean-Yves; Hou, Mi; Hou, Wei-Shu; Howell, David; Hronek, Maxine; Hsiung, Yee B.; Hu, Bo; Hu, Tao; Huang, Jung-Yun; Huang, Tong Ming; Huang, Wen Hui; Huedem, Emil; Huggard, Peter; Hugonie, Cyril; Hu-Guo, Christine; Huitu, Katri; Hwang, Youngseok; Idzik, Marek; Ignatenko, Alexandr; Ignatov, Fedor; Ikeda, Hirokazu; Ikematsu, Katsumasa; Ilicheva, Tatiana; Imbault, Didier; Imhof, Andreas; Incagli, Marco; Ingbir, Ronen; Inoue, Hitoshi; Inoue, Youichi; Introzzi, Gianluca; Ioakeimidi, Katerina; Ishihara, Satoshi; Ishikawa, Akimasa; Ishikawa, Tadashi; Issakov, Vladimir; Ito, Kazutoshi; Ivanov, V.V.; Ivanov, Valentin; Ivanyushenkov, Yury; Iwasaki, Masako; Iwashita, Yoshihisa; Jackson, David; Jackson, Frank; Jacobsen, Bob; Jaganathan, Ramaswamy; Jamison, Steven; Janssen, Matthias Enno; Jaramillo-Echeverria, Richard; Jauffret, Clement; Jawale, Suresh B.; Jeans, Daniel; Jedziniak, Ron; Jeffery, Ben; Jehanno, Didier; Jenner, Leo J.; Jensen, Chris; Jensen, David R.; Jiang, Hairong; Jiang, Xiao Ming; Jimbo, Masato; Jin, Shan; Keith Jobe, R.; Johnson, Anthony; Johnson, Erik; Johnson, Matt; Johnston, Michael; Joireman, Paul; Jokic, Stevan; Jones, James; Jones, Roger M.; Jongewaard, Erik; Jönsson, Leif; Joshi, Gopal; Joshi, Satish C.; Jung, Jin-Young; Junk, Thomas; Juste, Aurelio; Kado, Marumi; Kadyk, John; Käfer, Daniela; Kako, Eiji; Kalavase, Puneeth; Kalinin, Alexander; Kalinowski, Jan; Kamitani, Takuya; Kamiya, Yoshio; Kamiya, Yukihide; Kamoshita, Jun-ichi; Kananov, Sergey; Kanaya, Kazuyuki; Kanazawa, Ken-ichi; Kanemura, Shinya; Kang, Heung-Sik; Kang, Wen; Kanjial, D.; Kapusta, Frédéric; Karataev, Pavel; Karchin, Paul E.; Karlen, Dean; Karyotakis, Yannis; Kashikhin, Vladimir; Kashiwagi, Shigeru; Kasley, Paul; Katagiri, Hiroaki; Kato, Takashi; Kato, Yukihiro; Katzy, Judith; Kaukher, Alexander; Kaur, Manjit; Kawagoe, Kiyotomo; Kawamura, Hiroyuki; Kazakov, Sergei; Kekelidze, V.D.; Keller, Lewis; Kelley, Michael; Kelly, Marc; Kelly, Michael; Kennedy, Kurt; Kephart, Robert; Keung, Justin; Khainovski, Oleg; Khan, Sameen Ahmed; Khare, Prashant; Khovansky, Nikolai; Kiesling, Christian; Kikuchi, Mitsuo; Kilian, Wolfgang; Killenberg, Martin; Kim, Donghee; Kim, Eun San; Kim, Eun-Joo; Kim, Guinyun; Kim, Hongjoo; Kim, Hyoungsuk; Kim, Hyun-Chui; Kim, Jonghoon; Kim, Kwang-Je; Kim, Kyung Sook; Kim, Peter; Kim, Seunghwan; Kim, Shin-Hong; Kim, Sun Kee; Kim, Tae Jeong; Kim, Youngim; Kim, Young-Kee; Kimmitt, Maurice; Kirby, Robert; Kircher, François; Kisielewska, Danuta; Kittel, Olaf; Klanner, Robert; Klebaner, Arkadiy L.; Kleinwort, Claus; Klimkovich, Tatsiana; Klinkby, Esben; Kluth, Stefan; Knecht, Marc; Kneisel, Peter; Ko, In Soo; Ko, Kwok; Kobayashi, Makoto; Kobayashi, Nobuko; Kobel, Michael; Koch, Manuel; Kodys, Peter; Koetz, Uli; Kohrs, Robert; Kojima, Yuuji; Kolanoski, Hermann; Kolodziej, Karol; Kolomensky, Yury G.; Komamiya, Sachio; Kong, Xiang Cheng; Konigsberg, Jacobo; Korbel, Volker; Koscielniak, Shane; Kostromin, Sergey; Kowalewski, Robert; Kraml, Sabine; Krammer, Manfred; Krasnykh, Anatoly; Krautscheid, Thorsten; Krawczyk, Maria; James Krebs, H.; Krempetz, Kurt; Kribs, Graham; Krishnagopal, Srinivas; Kriske, Richard; Kronfeld, Andreas; Kroseberg, Jürgen; Kruchonak, Uladzimir; Kruecker, Dirk; Krüger, Hans; Krumpa, Nicholas A.; Krumshtein, Zinovii; Kuang, Yu Ping; Kubo, Kiyoshi; Kuchler, Vic; Kudoh, Noboru; Kulis, Szymon; Kumada, Masayuki; Kumar, Abhay; Kume, Tatsuya; Kundu, Anirban; Kurevlev, German; Kurihara, Yoshimasa; Kuriki, Masao; Kuroda, Shigeru; Kuroiwa, Hirotoshi; Kurokawa, Shin-ichi; Kusano, Tomonori; Kush, Pradeep K.; Kutschke, Robert; Kuznetsova, Ekaterina; Kvasnicka, Peter; Kwon, Youngjoon; Labarga, Luis; Lacasta, Carlos; Lackey, Sharon; Lackowski, Thomas W.; Lafaye, Remi; Lafferty, George; Lagorio, Eric; Laktineh, Imad; Lal, Shankar; Laloum, Maurice; Lam, Briant; Lancaster, Mark; Lander, Richard; Lange, Wolfgang; Langenfeld, Ulrich; Langeveld, Willem; Larbalestier, David; Larsen, Ray; Lastovicka, Tomas; Lastovicka-Medin, Gordana; Latina, Andrea; Latour, Emmanuel; Laurent, Lisa; Le, Ba Nam; Le, Duc Ninh; Le Diberder, Francois; Dû, Patrick Le; Lebbolo, Hervé; Lebrun, Paul; Lecoq, Jacques; Lee, Sung-Won; Lehner, Frank; Leibfritz, Jerry; Lenkszus, Frank; Lesiak, Tadeusz; Levy, Aharon; Lewandowski, Jim; Leyh, Greg; Li, Cheng; Li, Chong Sheng; Li, Chun Hua; Li, Da Zhang; Li, Gang; Li, Jin; Li, Shao Peng; Li, Wei Ming; Li, Weiguo; Li, Xiao Ping; Li, Xue-Qian; Li, Yuanjing; Li, Yulan; Li, Zenghai; Li, Zhong Quan; Liang, Jian Tao; Liao, Yi; Lilje, Lutz; Guilherme Lima, J.; Lintern, Andrew J.; Lipton, Ronald; List, Benno; List, Jenny; Liu, Chun; Liu, Jian Fei; Liu, Ke Xin; Liu, Li Qiang; Liu, Shao Zhen; Liu, Sheng Guang; Liu, Shubin; Liu, Wanming; Liu, Wei Bin; Liu, Ya Ping; Liu, Yu Dong; Lockyer, Nigel; Logan, Heather E.; Logatchev, Pavel V.; Lohmann, Wolfgang; Lohse, Thomas; Lola, Smaragda; Lopez-Virto, Amparo; Loveridge, Peter; Lozano, Manuel; Lu, Cai-Dian; Lu, Changguo; Lu, Gong-Lu; Lu, Wen Hui; Lubatti, Henry; Lucotte, Arnaud; Lundberg, Björn; Lundin, Tracy; Luo, Mingxing; Luong, Michel; Luth, Vera; Lutz, Benjamin; Lutz, Pierre; Lux, Thorsten; Luzniak, Pawel; Lyapin, Alexey; Lykken, Joseph; Lynch, Clare; Ma, Li; Ma, Lili; Ma, Qiang; Ma, Wen-Gan; Macfarlane, David; Maciel, Arthur; MacLeod, Allan; MacNair, David; Mader, Wolfgang; Magill, Stephen; Magnan, Anne-Marie; Maiheu, Bino; Maity, Manas; Majchrzak, Millicent; Majumder, Gobinda; Makarov, Roman; Makowski, Dariusz; Malaescu, Bogdan; Mallik, C.; Mallik, Usha; Malton, Stephen; Malyshev, Oleg B.; Malysheva, Larisa I.; Mammosser, John; Mamta; Mamuzic, Judita; Manen, Samuel; Manghisoni, Massimo; Manly, Steven; Marcellini, Fabio; Marcisovsky, Michal; Markiewicz, Thomas W.; Marks, Steve; Marone, Andrew; Marti, Felix; Martin, Jean-Pierre; Martin, Victoria; Martin-Chassard, Gisèle; Martinez, Manel; Martinez-Rivero, Celso; Martsch, Dennis; Martyn, Hans-Ulrich; Maruyama, Takashi; Masuzawa, Mika; Mathez, Hervé; Matsuda, Takeshi; Matsumoto, Hiroshi; Matsumoto, Shuji; Matsumoto, Toshihiro; Matsunaga, Hiroyuki; Mättig, Peter; Mattison, Thomas; Mavromanolakis, Georgios; Mawatari, Kentarou; Mazzacane, Anna; McBride, Patricia; McCormick, Douglas; McCormick, Jeremy; McDonald, Kirk T.; McGee, Mike; McIntosh, Peter; McKee, Bobby; McPherson, Robert A.; Meidlinger, Mandi; Meier, Karlheinz; Mele, Barbara; Meller, Bob; Melzer-Pellmann, Isabell-Alissandra; Mendez, Hector; Mercer, Adam; Merkin, Mikhail; Meshkov, I.N.; Messner, Robert; Metcalfe, Jessica; Meyer, Chris; Meyer, Hendrik; Meyer, Joachim; Meyer, Niels; Meyners, Norbert; Michelato, Paolo; Michizono, Shinichiro; Mihalcea, Daniel; Mihara, Satoshi; Mihara, Takanori; Mikami, Yoshinari; Mikhailichenko, Alexander A.; Milardi, Catia; Miller, David J.; Miller, Owen; Miller, Roger J.; Milstene, Caroline; Mimashi, Toshihiro; Minashvili, Irakli; Miquel, Ramon; Mishra, Shekhar; Mitaroff, Winfried; Mitchell, Chad; Miura, Takako; Miyata, Hitoshi; Mjörnmark, Ulf; Mnich, Joachim; Moenig, Klaus; Moffeit, Kenneth; Mokhov, Nikolai; Molloy, Stephen; Monaco, Laura; Monasterio, Paul R.; Montanari, Alessandro; Moon, Sung Ik; Moortgat-Pick, Gudrid A.; Mora de Freitas, Paulo; Morel, Federic; Moretti, Stefano; Morgunov, Vasily; Mori, Toshinori; Morin, Laurent; Morisseau, François; Morita, Yoshiyuki; Morita, Youhei; Morita, Yuichi; Morozov, Nikolai; Morozumi, Yuichi; Morse, William; Moser, Hans-Guenther; Moultaka, Gilbert; Mtingwa, Sekazi; Mudrinic, Mihajlo; Mueller, Alex; Mueller, Wolfgang; Muennich, Astrid; Muhlleitner, Milada Margarete; Mukherjee, Bhaskar; Mukhopadhyaya, Biswarup; Müller, Thomas; Munro, Morrison; Murayama, Hitoshi; Muto, Toshiya; Myneni, Ganapati Rao; Nabhiraj, P.Y.; Nagaitsev, Sergei; Nagamine, Tadashi; Nagano, Ai; Naito, Takashi; Nakai, Hirotaka; Nakajima, Hiromitsu; Nakamura, Isamu; Nakamura, Tomoya; Nakanishi, Tsutomu; Nakao, Katsumi; Nakao, Noriaki; Nakayoshi, Kazuo; Nam, Sang; Namito, Yoshihito; Namkung, Won; Nantista, Chris; Napoly, Olivier; Narain, Meenakshi; Naroska, Beate; Nauenberg, Uriel; Nayyar, Ruchika; Neal, Homer; Nelson, Charles; Nelson, Janice; Nelson, Timothy; Nemecek, Stanislav; Neubauer, Michael; Neuffer, David; Newman, Myriam Q.; Nezhevenko, Oleg; Ng, Cho-Kuen; Nguyen, Anh Ky; Nguyen, Minh; Van Nguyen Thi,Hong; Niebuhr, Carsten; Niehoff, Jim; Niezurawski, Piotr; Nishitani, Tomohiro; Nitoh, Osamu; Noguchi, Shuichi; Nomerotski, Andrei; Noonan, John; Norbeck, Edward; Nosochkov, Yuri; Notz, Dieter; Nowak, Grazyna; Nowak, Hannelies; Noy, Matthew; Nozaki, Mitsuaki; Nyffeler, Andreas; Nygren, David; Oddone, Piermaria; O'Dell, Joseph; Oh, Jong-Seok; Oh, Sun Kun; Ohkuma, Kazumasa; Ohlerich, Martin; Ohmi, Kazuhito; Ohnishi, Yukiyoshi; Ohsawa, Satoshi; Ohuchi, Norihito; Oide, Katsunobu; Okada, Nobuchika; Okada, Yasuhiro; Okamura, Takahiro; Okugi, Toshiyuki; Okumi, Shoji; Okumura, Ken-ichi; Olchevski, Alexander; Oliver, William; Olivier, Bob; Olsen, James; Olsen, Jeff; Olsen, Stephen; Olshevsky, A.G.; Olsson, Jan; Omori, Tsunehiko; Onel, Yasar; Onengut, Gulsen; Ono, Hiroaki; Onoprienko, Dmitry; Oreglia, Mark; Oren, Will; Orimoto, Toyoko J.; Oriunno, Marco; Orlandea, Marius Ciprian; Oroku, Masahiro; Orr, Lynne H.; Orr, Robert S.; Oshea, Val; Oskarsson, Anders; Osland, Per; Ossetski, Dmitri; Österman, Lennart; Ostiguy, Francois; Otono, Hidetoshi; Ottewell, Brian; Ouyang, Qun; Padamsee, Hasan; Padilla, Cristobal; Pagani, Carlo; Palmer, Mark A.; Pam, Wei Min; Pande, Manjiri; Pande, Rajni; Pandit, V.S.; Pandita, P.N.; Pandurovic, Mila; Pankov, Alexander; Panzeri, Nicola; Papandreou, Zisis; Paparella, Rocco; Para, Adam; Park, Hwanbae; Parker, Brett; Parkes, Chris; Parma, Vittorio; Parsa, Zohreh; Parsons, Justin; Partridge, Richard; Pasquinelli, Ralph; Pásztor, Gabriella; Paterson, Ewan; Patrick, Jim; Patteri, Piero; Ritchie Patterson, J.; Pauletta, Giovanni; Paver, Nello; Pavlicek, Vince; Pawlik, Bogdan; Payet, Jacques; Pchalek, Norbert; Pedersen, John; Pei, Guo Xi; Pei, Shi Lun; Pelka, Jerzy; Pellegrini, Giulio; Pellett, David; Peng, G.X.; Penn, Gregory; Penzo, Aldo; Perry, Colin; Peskin, Michael; Peters, Franz; Petersen, Troels Christian; Peterson, Daniel; Peterson, Thomas; Petterson, Maureen; Pfeffer, Howard; Pfund, Phil; Phelps, Alan; Van Phi, Quang; Phillips, Jonathan; Phinney, Nan; Piccolo, Marcello; Piemontese, Livio; Pierini, Paolo; Thomas Piggott, W.; Pike, Gary; Pillet, Nicolas; Jayawardena, Talini Pinto; Piot, Phillippe; Pitts, Kevin; Pivi, Mauro; Plate, Dave; Pleier, Marc-Andre; Poblaguev, Andrei; Poehler, Michael; Poelker, Matthew; Poffenberger, Paul; Pogorelsky, Igor; Poirier, Freddy; Poling, Ronald; Poole, Mike; Popescu, Sorina; Popielarski, John; Pöschl, Roman; Postranecky, Martin; Potukochi, Prakash N.; Prast, Julie; Prat, Serge; Preger, Miro; Prepost, Richard; Price, Michael; Proch, Dieter; Puntambekar, Avinash; Qin, Qing; Qu, Hua Min; Quadt, Arnulf; Quesnel, Jean-Pierre; Radeka, Veljko; Rahmat, Rahmat; Rai, Santosh Kumar; Raimondi, Pantaleo; Ramberg, Erik; Ranjan, Kirti; Rao, Sista V.L.S.; Raspereza, Alexei; Ratti, Alessandro; Ratti, Lodovico; Raubenheimer, Tor; Raux, Ludovic; Ravindran, V.; Raychaudhuri, Sreerup; Re, Valerio; Rease, Bill; Reece, Charles E.; Regler, Meinhard; Rehlich, Kay; Reichel, Ina; Reichold, Armin; Reid, John; Reid, Ron; Reidy, James; Reinhard, Marcel; Renz, Uwe; Repond, Jose; Resta-Lopez, Javier; Reuen, Lars; Ribnik, Jacob; Rice, Tyler; Richard, François; Riemann, Sabine; Riemann, Tord; Riles, Keith; Riley, Daniel; Rimbault, Cécile; Rindani, Saurabh; Rinolfi, Louis; Risigo, Fabio; Riu, Imma; Rizhikov, Dmitri; Rizzo, Thomas; Rochford, James H.; Rodriguez, Ponciano; Roeben, Martin; Rolandi, Gigi; Roodman, Aaron; Rosenberg, Eli; Roser, Robert; Ross, Marc; Rossel, François; Rossmanith, Robert; Roth, Stefan; Rougé, André; Rowe, Allan; Roy, Amit; Roy, Sendhunil B.; Roy, Sourov; Royer, Laurent; Royole-Degieux, Perrine; Royon, Christophe; Ruan, Manqi; Rubin, David; Ruehl, Ingo; Jimeno, Alberto Ruiz; Ruland, Robert; Rusnak, Brian; Ryu, Sun-Young; Sabbi, Gian Luca; Sadeh, Iftach; Sadygov, Ziraddin Y; Saeki, Takayuki; Sagan, David; Sahni, Vinod C.; Saini, Arun; Saito, Kenji; Saito, Kiwamu; Sajot, Gerard; Sakanaka, Shogo; Sakaue, Kazuyuki; Salata, Zen; Salih, Sabah; Salvatore, Fabrizio; Samson, Joergen; Sanami, Toshiya; Levi Sanchez, Allister; Sands, William; Santic, John; Sanuki, Tomoyuki; Sapronov, Andrey; Sarkar, Utpal; Sasao, Noboru; Satoh, Kotaro; Sauli, Fabio; Saunders, Claude; Saveliev, Valeri; Savoy-Navarro, Aurore; Sawyer, Lee; Saxton, Laura; Schäfer, Oliver; Schälicke, Andreas; Schade, Peter; Schaetzel, Sebastien; Scheitrum, Glenn; Schibler, Emilie; Schindler, Rafe; Schlösser, Markus; Schlueter, Ross D.; Schmid, Peter; Schmidt, Ringo Sebastian; Schneekloth, Uwe; Schreiber, Heinz Juergen; Schreiber, Siegfried; Schroeder, Henning; Peter Schüler, K.; Schulte, Daniel; Schultz-Coulon, Hans-Christian; Schumacher, Markus; Schumann, Steffen; Schumm, Bruce A.; Schwienhorst, Reinhard; Schwierz, Rainer; Scott, Duncan J.; Scuri, Fabrizio; Sefkow, Felix; Sefri, Rachid; Seguin-Moreau, Nathalie; Seidel, Sally; Seidman, David; Sekmen, Sezen; Seletskiy, Sergei; Senaha, Eibun; Senanayake, Rohan; Sendai, Hiroshi; Sertore, Daniele; Seryi, Andrei; Settles, Ronald; Sever, Ramazan; Shales, Nicholas; Shao, Ming; Shelkov, G.A.; Shepard, Ken; Shepherd-Themistocleous, Claire; Sheppard, John C.; Shi, Cai Tu; Shidara, Tetsuo; Shim, Yeo-Jeong; Shimizu, Hirotaka; Shimizu, Yasuhiro; Shimizu, Yuuki; Shimogawa, Tetsushi; Shin, Seunghwan; Shioden, Masaomi; Shipsey, Ian; Shirkov, Grigori; Shishido, Toshio; Shivpuri, Ram K.; Shrivastava, Purushottam; Shulga, Sergey; Shumeiko, Nikolai; Shuvalov, Sergey; Si, Zongguo; Siddiqui, Azher Majid; Siegrist, James; Simon, Claire; Simrock, Stefan; Sinev, Nikolai; Singh, Bhartendu K.; Singh, Jasbir; Singh, Pitamber; Singh, R.K.; Singh, S.K.; Singini, Monito; Sinha, Anil K.; Sinha, Nita; Sinha, Rahul; Sinram, Klaus; Sissakian, A.N.; Skachkov, N.B.; Skrinsky, Alexander; Slater, Mark; Slominski, Wojciech; Smiljanic, Ivan; Smith, A J Stewart; Smith, Alex; Smith, Brian J.; Smith, Jeff; Smith, Jonathan; Smith, Steve; Smith, Susan; Smith, Tonee; Neville Snodgrass, W.; Sobloher, Blanka; Sohn, Young-Uk; Solidum, Ruelson; Solyak, Nikolai; Son, Dongchul; Sonmez, Nasuf; Sopczak, Andre; Soskov, V.; Spencer, Cherrill M.; Spentzouris, Panagiotis; Speziali, Valeria; Spira, Michael; Sprehn, Daryl; Sridhar, K.; Srivastava, Asutosh; St. Lorant, Steve; Stahl, Achim; Stanek, Richard P.; Stanitzki, Marcel; Stanley, Jacob; Stefanov, Konstantin; Stein, Werner; Steiner, Herbert; Stenlund, Evert; Stern, Amir; Sternberg, Matt; Stockinger, Dominik; Stockton, Mark; Stoeck, Holger; Strachan, John; Strakhovenko, V.; Strauss, Michael; Striganov, Sergei I.; Strologas, John; Strom, David; Strube, Jan; Stupakov, Gennady; Su, Dong; Sudo, Yuji; Suehara, Taikan; Suehiro, Toru; Suetsugu, Yusuke; Sugahara, Ryuhei; Sugimoto, Yasuhiro; Sugiyama, Akira; Suh, Jun Suhk; Sukovic, Goran; Sun, Hong; Sun, Stephen; Sun, Werner; Sun, Yi; Sun, Yipeng; Suszycki, Leszek; Sutcliffe, Peter; Suthar, Rameshwar L.; Suwada, Tsuyoshi; Suzuki, Atsuto; Suzuki, Chihiro; Suzuki, Shiro; Suzuki, Takashi; Swent, Richard; Swientek, Krzysztof; Swinson, Christina; Syresin, Evgeny; Szleper, Michal; Tadday, Alexander; Takahashi, Rika; Takahashi, Tohru; Takano, Mikio; Takasaki, Fumihiko; Takeda, Seishi; Takenaka, Tateru; Takeshita, Tohru; Takubo, Yosuke; Tanaka, Masami; Tang, Chuan Xiang; Taniguchi, Takashi; Tantawi, Sami; Tapprogge, Stefan; Tartaglia, Michael A.; Tassielli, Giovanni Francesco; Tauchi, Toshiaki; Tavian, Laurent; Tawara, Hiroko; Taylor, Geoffrey; Telnov, Alexandre V.; Telnov, Valery; Tenenbaum, Peter; Teodorescu, Eliza; Terashima, Akio; Terracciano, Giuseppina; Terunuma, Nobuhiro; Teubner, Thomas; Teuscher, Richard; Theilacker, Jay; Thomson, Mark; Tice, Jeff; Tigner, Maury; Timmermans, Jan; Titov, Maxim; Toge, Nobukazu; Tokareva, N.A.; Tollefson, Kirsten; Tomasek, Lukas; Tomovic, Savo; Tompkins, John; Tonutti, Manfred; Topkar, Anita; Toprek, Dragan; Toral, Fernando; Torrence, Eric; Traversi, Gianluca; Trimpl, Marcel; Mani Tripathi, S.; Trischuk, William; Trodden, Mark; Trubnikov, G.V.; Tschirhart, Robert; Tskhadadze, Edisher; Tsuchiya, Kiyosumi; Tsukamoto, Toshifumi; Tsunemi, Akira; Tucker, Robin; Turchetta, Renato; Tyndel, Mike; Uekusa, Nobuhiro; Ueno, Kenji; Umemori, Kensei; Ummenhofer, Martin; Underwood, David; Uozumi, Satoru; Urakawa, Junji; Urban, Jeremy; Uriot, Didier; Urner, David; Ushakov, Andrei; Usher, Tracy; Uzunyan, Sergey; Vachon, Brigitte; Valerio, Linda; Valin, Isabelle; Valishev, Alex; Vamra, Raghava; Van der Graaf, Harry; Van Kooten, Rick; Van Zandbergen, Gary; Vanel, Jean-Charles; Variola, Alessandro; Varner, Gary; Velasco, Mayda; Velte, Ulrich; Velthuis, Jaap; Vempati, Sundir K.; Venturini, Marco; Vescovi, Christophe; Videau, Henri; Vila, Ivan; Vincent, Pascal; Virey, Jean-Marc; Visentin, Bernard; Viti, Michele; Vo, Thanh Cuong; Vogel, Adrian; Vogt, Harald; von Toerne, Eckhard; Vorozhtsov, S.B.; Vos, Marcel; Votava, Margaret; Vrba, Vaclav; Wackeroth, Doreen; Wagner, Albrecht; Wagner, Carlos E.M.; Wagner, Stephen; Wake, Masayoshi; Walczak, Roman; Walker, Nicholas J.; Walkowiak, Wolfgang; Wallon, Samuel; Walsh, Roberval; Walston, Sean; Waltenberger, Wolfgang; Walz, Dieter; Wang, Chao En; Wang, Chun Hong; Wang, Dou; Wang, Faya; Wang, Guang Wei; Wang, Haitao; Wang, Jiang; Wang, Jiu Qing; Wang, Juwen; Wang, Lanfa; Wang, Lei; Wang, Min-Zu; Wang, Qing; Wang, Shu Hong; Wang, Xiaolian; Wang, Xue-Lei; Wang, Yi Fang; Wang, Zheng; Wanzenberg, Rainer; Ward, Bennie; Ward, David; Warmbein, Barbara; Warner, David W.; Warren, Matthew; Washio, Masakazu; Watanabe, Isamu; Watanabe, Ken; Watanabe, Takashi; Watanabe, Yuichi; Watson, Nigel; Wattimena, Nanda; Wayne, Mitchell; Weber, Marc; Weerts, Harry; Weiglein, Georg; Weiland, Thomas; Weinzierl, Stefan; Weise, Hans; Weisend, John; Wendt, Manfred; Wendt, Oliver; Wenzel, Hans; Wenzel, William A.; Wermes, Norbert; Werthenbach, Ulrich; Wesseln, Steve; Wester, William; White, Andy; White, Glen R.; Wichmann, Katarzyna; Wienemann, Peter; Wierba, Wojciech; Wilksen, Tim; Willis, William; Wilson, Graham W.; Wilson, John A.; Wilson, Robert; Wing, Matthew; Winter, Marc; Wirth, Brian D.; Wolbers, Stephen A.; Wolff, Dan; Wolski, Andrzej; Woodley, Mark D.; Woods, Michael; Woodward, Michael L.; Woolliscroft, Timothy; Worm, Steven; Wormser, Guy; Wright, Dennis; Wright, Douglas; Wu, Andy; Wu, Tao; Wu, Yue Liang; Xella, Stefania; Xia, Guoxing; Xia, Lei; Xiao, Aimin; Xiao, Liling; Xie, Jia Lin; Xing, Zhi-Zhong; Xiong, Lian You; Xu, Gang; Xu, Qing Jing; Yajnik, Urjit A.; Yakimenko, Vitaly; Yamada, Ryuji; Yamaguchi, Hiroshi; Yamamoto, Akira; Yamamoto, Hitoshi; Yamamoto, Masahiro; Yamamoto, Naoto; Yamamoto, Richard; Yamamoto, Yasuchika; Yamanaka, Takashi; Yamaoka, Hiroshi; Yamashita, Satoru; Yamazaki, Hideki; Yan, Wenbiao; Yang, Hai-Jun; Yang, Jin Min; Yang, Jongmann; Yang, Zhenwei; Yano, Yoshiharu; Yazgan, Efe; Yeh, G.P.; Yilmaz, Hakan; Yock, Philip; Yoda, Hakutaro; Yoh, John; Yokoya, Kaoru; Yokoyama, Hirokazu; York, Richard C.; Yoshida, Mitsuhiro; Yoshida, Takuo; Yoshioka, Tamaki; Young, Andrew; Yu, Cheng Hui; Yu, Jaehoon; Yu, Xian Ming; Yuan, Changzheng; Yue, Chong-Xing; Yue, Jun Hui; Zacek, Josef; Zagorodnov, Igor; Zalesak, Jaroslav; Zalikhanov, Boris; Zarnecki, Aleksander Filip; Zawiejski, Leszek; Zeitnitz, Christian; Zeller, Michael; Zerwas, Dirk; Zerwas, Peter; Zeyrek, Mehmet; Zhai, Ji Yuan; Zhang, Bao Cheng; Zhang, Bin; Zhang, Chuang; Zhang, He; Zhang, Jiawen; Zhang, Jing; Zhang, Jing Ru; Zhang, Jinlong; Zhang, Liang; Zhang, X.; Zhang, Yuan; Zhang, Zhige; Zhang, Zhiqing; Zhang, Ziping; Zhao, Haiwen; Zhao, Ji Jiu; Zhao, Jing Xia; Zhao, Ming Hua; Zhao, Sheng Chu; Zhao, Tianchi; Zhao, Tong Xian; Zhao, Zhen Tang; Zhao, Zhengguo; Zhou, De Min; Zhou, Feng; Zhou, Shun; Zhu, Shou Hua; Zhu, Xiong Wei; Zhukov, Valery; Zimmermann, Frank; Ziolkowski, Michael; Zisman, Michael S.; Zomer, Fabian; Zong, Zhang Guo; Zorba, Osman; Zutshi, Vishnu

2007-01-01

This report, Volume IV of the International Linear Collider Reference Design Report, describes the detectors which will record and measure the charged and neutral particles produced in the ILC's high energy e+e- collisions. The physics of the ILC, and the environment of the machine-detector interface, pose new challenges for detector design. Several conceptual designs for the detector promise the needed performance, and ongoing detector R&D is addressing the outstanding technological issues. Two such detectors, operating in push-pull mode, perfectly instrument the ILC interaction region, and access the full potential of ILC physics.

The environmental impact statement for the Nevada Test Site and off-site locations in the State of Nevada. Volume 1, Appendices A-F

International Nuclear Information System (INIS)

1996-01-01

This volume contains appendices to the named document. The Appendices are entitled (A) Description of Projects and Activities, (2) Federal Register Notice, (C) Relevant Regulatory Requirements, (D) Distribution Lists, (E) Impact Assessment Methods, and (F) Project-Specific Environmental Analysis

Computations of nuclear response functions with MACK-IV

International Nuclear Information System (INIS)

Abdou, M.A.; Gohar, Y.

1978-01-01

The MACK computer program calculates energy pointwise and multigroup nuclear response functions from basic nuclear data in ENDF/B format. The new version of the program, MACK-IV, incorporates major developments and improvements aimed at maximizing the utilization of available nuclear data and ensuring energy conservation in nuclear heating calculations. A new library, MACKLIB-IV, of nuclear response functions was generated in the CTR energy group structure of 171 neutron groups and 36 gamma groups. The library was prepared using MACK-IV and ENDF/B-IV and is suitable for fusion, fusion-fission hybrids, and fission applications

Computations of nuclear response functions with MACK-IV

Energy Technology Data Exchange (ETDEWEB)

Abdou, M A; Gohar, Y

1978-01-01

The MACK computer program calculates energy pointwise and multigroup nuclear response functions from basic nuclear data in ENDF/B format. The new version of the program, MACK-IV, incorporates major developments and improvements aimed at maximizing the utilization of available nuclear data and ensuring energy conservation in nuclear heating calculations. A new library, MACKLIB-IV, of nuclear response functions was generated in the CTR energy group structure of 171 neutron groups and 36 gamma groups. The library was prepared using MACK-IV and ENDF/B-IV and is suitable for fusion, fusion-fission hybrids, and fission applications.

Industrial Fuel Gas Demonstration Plant Program. Conceptual design and evaluation of commercial plant. Volume III. Economic analyses (Deliverable Nos. 15 and 16)

Energy Technology Data Exchange (ETDEWEB)

None

1978-01-01

This report presents the results of Task I of Phase I in the form of a Conceptual Design and Evaluation of Commercial Plant report. The report is presented in four volumes as follows: I - Executive Summary, II - Commercial Plant Design, III - Economic Analyses, IV - Demonstration Plant Recommendations. Volume III presents the economic analyses for the commercial plant and the supporting data. General cost and financing factors used in the analyses are tabulated. Three financing modes are considered. The product gas cost calculation procedure is identified and appendices present computer inputs and sample computer outputs for the MLGW, Utility, and Industry Base Cases. The results of the base case cost analyses for plant fenceline gas costs are as follows: Municipal Utility, (e.g. MLGW), $3.76/MM Btu; Investor Owned Utility, (25% equity), $4.48/MM Btu; and Investor Case, (100% equity), $5.21/MM Btu. The results of 47 IFG product cost sensitivity cases involving a dozen sensitivity variables are presented. Plant half size, coal cost, plant investment, and return on equity (industrial) are the most important sensitivity variables. Volume III also presents a summary discussion of the socioeconomic impact of the plant and a discussion of possible commercial incentives for development of IFG plants.

[Surgical treatment of the primary tumor in stage IV breast cancer].

Science.gov (United States)

Jiménez Anula, Juan; Sánchez Andújar, Belén; Machuca Chiriboga, Pablo; Navarro Cecilia, Joaquín; Dueñas Rodríguez, Basilio

2015-01-01

The aim of the study was to analyze the impact of loco-regional surgery on survival of patients with stage IV breast cancer. Retrospective study that included patients with breast cancer and synchronous metastases. Patients with ECOG above 2 and high-risk patients were excluded. The following variables were evaluated: age, tumor size, nodal involvement, histological type, histological grade, hormone receptor status, HER2 overexpression, number of affected organs, location of metastases and surgical treatment. The impact of surgery and several clinical and pathologic variables on survival was analyzed by Cox regression model. A total of 69 patients, of whom 36 (52.2%) underwent surgery (study group) were included. After a mean follow-up of 34 months, the median survival of the series was 55 months and no significant differences between the study group and the group of patients without surgery (P=0.187) were found. Two factors associated with worse survival were identified: the number of organs with metastases (HR=1.69, IC 95%: 1.05-2.71) and triple negative breast cancer (HR=3.49, IC 95%: 1.39-8.74). Loco-regional surgery, however, was not associated with survival. Loco-regional surgical treatment was not associated with improved survival inpacientes with stage IV breast cancer. The number of organs with metastases and tumors were triple negative prognostic factors for survival. Copyright © 2014 AEC. Publicado por Elsevier España, S.L.U. All rights reserved.

Redox behavior of Ce(IV)/Ce(III) in the presence of nitrilotriacetic acid: a surrogate study for An(IV)/An(III) redox behavior

International Nuclear Information System (INIS)

Suzuki, Y.; Nankawa, T.; Ohnuki, T.; Francis, A.J.

2010-01-01

Using cyclic voltammetry, we investigated the redox behavior of Ce(IV)/Ce(III), which is a surrogate for An(IV)/An(III) (An = actinides), in a solution of nitrilotriacetic acid (NTA) at 25 C. The cyclic voltammogram of Ce in a 0.1 M NTA solution at pH 6 showed a reversible one-electron redox reaction for Ce(IV)/Ce(III) at 0.51 V vs. Ag/AgCl. This redox potential was much lower than that obtained in 1 M nitric acid, indicating that Ce(IV) was preferentially stabilized by complexation with NTA. The redox potential in the NTA solution was independent of the Ce concentration from 2 to 20 mM, NTA concentration from 5 to 200 mM and pH between 3 and 7. These results indicated that no polymerization and no additional coordination of NTA and OH to the Ce(III)-NTA complex took place during the redox reaction. As the speciation calculation of Ce(III) in the NTA solution showed that the predominant species was Ce III (nta) 2 3 (H 3 nta = NTA), the redox reaction of the Ce-NTA complex was expressed by the following: Ce IV (nta) 2 2- + e - ↔ Ce III (nta) 2 3 . The logarithm of the stability constant of Ce IV (nta) 2 2- was calculated to be 38.6 ± 0.8 for I = 0 from the redox potential shift of Ce(IV)/Ce(III) in the NTA solution. The value was in good accordance with the stability constant of the Np IV (nta) 2 2- complex, demonstrating that the aqueous coordination chemistry of Ce(IV) with NTA is quite similar to that of An(IV). These results strongly suggest that a negative shift of the Pu(IV)/Pu(III) redox potential in the NTA solution should make Pu(IV) more stable than Pu(III) even in a reducing environment. (orig.)

Mechanical Behaviour of Materials Volume II Fracture Mechanics and Damage

CERN Document Server

François, Dominique; Zaoui, André

2013-01-01

Designing new structural materials, extending lifetimes and guarding against fracture in service are among the preoccupations of engineers, and to deal with these they need to have command of the mechanics of material behaviour. This ought to reflect in the training of students. In this respect, the first volume of this work deals with elastic, elastoplastic, elastoviscoplastic and viscoelastic behaviours; this second volume continues with fracture mechanics and damage, and with contact mechanics, friction and wear. As in Volume I, the treatment links the active mechanisms on the microscopic scale and the laws of macroscopic behaviour. Chapter I is an introduction to the various damage phenomena. Chapter II gives the essential of fracture mechanics. Chapter III is devoted to brittle fracture, chapter IV to ductile fracture and chapter V to the brittle-ductile transition. Chapter VI is a survey of fatigue damage. Chapter VII is devoted to hydogen embrittlement and to environment assisted cracking, chapter VIII...

Safety assessment for Generation IV nuclear systems

International Nuclear Information System (INIS)

Leahy, T.J.

2012-01-01

The Generation IV International Forum (GIF) Risk and Safety Working Group (RSWG) was created to develop an effective approach for the safety of Generation IV advanced nuclear energy systems. Recent RSWG work has focused on the definition of an integrated safety assessment methodology (ISAM) for evaluating the safety of Generation IV systems. ISAM is an integrated 'tool-kit' consisting of 5 analytical techniques that are available and matched to appropriate stages of Generation IV system concept development: 1) qualitative safety features review - QSR, 2) phenomena identification and ranking table - PIRT, 3) objective provision tree - OPT, 4) deterministic and phenomenological analyses - DPA, and 5) probabilistic safety analysis - PSA. The integrated methodology is intended to yield safety-related insights that help actively drive the evolving design throughout the technology development cycle, potentially resulting in enhanced safety, reduced costs, and shortened development time

Eating disorder not otherwise specified in an inpatient unit: the impact of altering the DSM-IV criteria for anorexia and bulimia nervosa.

Science.gov (United States)

Dalle Grave, Riccardo; Calugi, Simona

2007-09-01

To evaluate (1) the Eating Disorder Not Otherwise Specified (EDNOS) prevalence in an eating disorder inpatient unit; (2) the impact of altering the diagnostic criteria for anorexia nervosa and bulimia nervosa on the prevalence of EDNOS. One hundred and eighty six eating disorder patients consecutively hospitalised were included in the study. The prevalence of anorexia nervosa, bulimia nervosa and EDNOS was evaluated with the Eating Disorder Examination (EDE). The EDNOS prevalence was recalculated after the alteration of three diagnostic criteria for anorexia nervosa and one for bulimia nervosa. Seventy eight patients (41.9%) met the diagnostic criteria for anorexia nervosa, 33 (17.8%) for bulimia nervosa and 75 (40.3%) for EDNOS. The alteration of the DSM-IV diagnostic criteria reduced the prevalence of EDNOS to 28 cases (15%). EDNOS is a very frequent diagnostic category in an inpatient setting. Altering the diagnostic criteria for anorexia nervosa and bulimia nervosa reduced significantly the prevalence of EDNOS. 2007 John Wiley & Sons, Ltd and Eating Disorders Association

Dosimetric impact of prostate volume change between CT-based HDR brachytherapy fractions

International Nuclear Information System (INIS)

Kim, Yongbok; Hsu, I-C.; Lessard, Etienne; Vujic, Jasmina; Pouliot, Jean

2004-01-01

Purpose: The objective is to evaluate the prostate volume change and its dosimetric consequences after the insertion of catheters for high-dose-rate brachytherapy. Methods and Materials: For 13 consecutive patients, a spiral CT scan was acquired before each of the 2 fractions, separated on average by 20 hours. The coordinates of the catheters were obtained on 3 axial CT slices corresponding to apex, mid portion, and base portion of the prostate. A mathematical expansion model was used to evaluate the change of prostate volumes between the 2 fractions. It is based on the difference in the cube of the average distance between the centroid and catheter positions. The variation of implant dose-volume histograms between fractions was computed for plans produced by either inverse planning based on simulated annealing or geometric optimization. Results: The average magnitude of either increase or reduction in prostate volume was 7.8% (range, 2-17%). This volume change corresponds to an average prostate radius change of only 2.5% (range, 0.7-5.4%). For 5 patients, the prostate volume increased on average by 9% (range, 2-17%), whereas a reduction was observed for 8 patients by an average of 7% (range, 2-13%). More variation was observed at the prostate base than at mid or apex gland. The comparison of implant dose-volume histograms showed a small reduction of V100 receiving the prescription dose, with an average of 3.5% (range, 0.5-12%) and 2.2% (range, 1-6%) for inverse planning based on our simulated annealing and geometric optimization plans, respectively. Conclusion: Small volume change was observed between treatment fractions. This translates into small changes in dose delivered to the prostate volume

Prognostic Factors for Hormone Sensitive Metastatic Prostate Cancer: Impact of Disease Volume

Science.gov (United States)

Alhanafy, Alshimaa Mahmoud; Zanaty, Fouad; Ibrahem, Reda; Omar, Suzan

2018-04-27

Background and Aim: The optimal management of metastatic hormone-sensitive prostate cancer has been controversial in recent years with introduction of upfront chemohormonal treatment based on results of several Western studies. This changing landscape has renewed interest in the concept “disease volume”, the focus of the present study is the Egyptian patients. Methods: Patients with hormone sensitive metastatic prostate cancer presenting at Menoufia University Hospital, Egypt, during the period from June 2013 to May 2016, were enrolled. All received hormonal treatment. Radiologic images were evaluated and patients were stratified according to their disease volume into high or low, other clinical and pathological data that could affect survival also being collected and analyzed. Results: A total of 128 patients were included, with a median age of 70 years (53.9% ≥70). About 46% had co-morbidities, 62% having high volume disease. During the median follow up period of 28 months about half of the patients progressed and one third received chemotherapy. On univariate analysis, disease volume, performance status (PS), prostate specific antigen level (PSA) and presence of pain at presentation were identified as factors influencing overall survival. Multivariate analysis revealed the independent predictor factors for survival to be PS, PSA and disease volume. The median overall survival with 27 months was high volume versus 49 with low volume disease (hazard ratio 2.1; 95% CI 1.2 - 4.4; P=0.02). Median progression free survival was 19 months in the high volume, as compared with 48 months in the low volume disease patients (hazard ratio, 2.44; 95% CI, 1.42 – 7.4; P=0.009). Conclusions: Disease volume is a reliable predictor of survival which should be incorporated with other important factors as; patient performance status and comorbidities in treatment decision-making. Creative Commons Attribution License

Childhood adversity is linked to differential brain volumes in adolescents with alcohol use disorder: a voxel-based morphometry study.

Science.gov (United States)

Brooks, Samantha J; Dalvie, Shareefa; Cuzen, Natalie L; Cardenas, Valerie; Fein, George; Stein, Dan J

2014-06-01

Previous neuroimaging studies link both alcohol use disorder (AUD) and early adversity to neurobiological differences in the adult brain. However, the association between AUD and childhood adversity and effects on the developing adolescent brain are less clear, due in part to the confound of psychiatric comorbidity. Here we examine early life adversity and its association with brain volume in a unique sample of 116 South African adolescents (aged 12-16) with AUD but without psychiatric comorbidity. Participants were 58 adolescents with DSM-IV alcohol dependence and with no other psychiatric comorbidities, and 58 age-, gender- and protocol-matched light/non-drinking controls (HC). Assessments included the Childhood Trauma Questionnaire (CTQ). MR images were acquired on a 3T Siemens Magnetom Allegra scanner. Volumes of global and regional structures were estimated using SPM8 Voxel Based Morphometry (VBM), with analysis of covariance (ANCOVA) and regression analyses. In whole brain ANCOVA analyses, a main effect of group when examining the AUD effect after covarying out CTQ was observed on brain volume in bilateral superior temporal gyrus. Subsequent regression analyses to examine how childhood trauma scores are linked to brain volumes in the total cohort revealed a negative correlation in the left hippocampus and right precentral gyrus. Furthermore, bilateral (but most significantly left) hippocampal volume was negatively associated with sub-scores on the CTQ in the total cohort. These findings support our view that some alterations found in brain volumes in studies of adolescent AUD may reflect the impact of confounding factors such as psychiatric comorbidity rather than the effects of alcohol per se. In particular, early life adversity may influence the developing adolescent brain in specific brain regions, such as the hippocampus.

U(IV) fluorescence spectroscopy. A new speciation tool

Energy Technology Data Exchange (ETDEWEB)

Lehmann, Susanne; Brendler, Vinzenz [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Surface Processes; Steudtner, Robin [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Inst. of Resource Ecology

2017-06-01

We combined absorption and fluorescence spectroscopy to study the speciation of U(IV) in solution in concentrations down to 10{sup -6} M uranium. With our time-resolved laser-induced fluorescence setup we could determine the fluorescence decay time of U(IV) in perchloric as well as in chloric acid with 2.6 ± 0.3 ns at room temperature and 148.4 ± 6.5 ns at liquid nitrogen temperature. For the U(IV) sulfate system, we observed a bathochromic shift and a peak shape modification in the fluorescence spectra with increasing sulfate concentration in solution. Thus, the potential of U(IV) fluorescence for speciation analysis could be proven.

The pharmacokinetics and safety of twice daily i.v. BU during conditioning in pediatric allo-SCT recipients.

Science.gov (United States)

Le Gall, J B; Milone, M C; Waxman, I M; Shaw, L M; Harrison, L; Duffy, D; van de Ven, C; Militano, O; Geyer, M B; Morris, E; Bhatia, M; Satwani, P; George, D; Garvin, J H; Bradley, M B; Schwartz, J; Baxter-Lowe, L A; Cairo, M S

2013-01-01

Intravenous BU divided four times daily (q6 h) has been shown to be safe and effective in pediatric allo-SCT recipients. Though less frequent dosing is desirable, pharmacokinetic (PK) data on twice daily (q12 h) i.v. BU administration in pediatric allo-SCT recipients is limited. We prospectively examined the PK results in a cohort of pediatric allo-SCT recipients receiving i.v. BU q12 h as part of conditioning before allo-SCT. BU levels were obtained after the first dose of conditioning. PK parameter analysis (n=49) yielded the following 95% confidence intervals (CI₉₅): weight-normalized volume of distribution: 0.65-0.73 L/kg; t(1/2): 122-147 min; weight-normalized clearance (CL(n)): 3.4-4.3 mL/min/kg; and area under the curve: 1835-2180 mmol × min/L. From these results, a steady state concentration was calculated with CI₉₅ between 628-746 ng/mL. Comparison between recipients ≤4 vs >4 years old revealed significant differences in t(1/2) (mean: 115 vs 146 min, P=0.008) and CL(n) (mean: 4.4 vs 3.5 mL/min/kg, P=0.038). Intravenous BU q12 h had a comparable PK to i.v. BU q6 h PK seen in the literature, and in pediatric allo-SCT recipients, is a feasible, attractive alternative to i.v. q6h dosing.

Beach Profile Analysis System (BPAS). Volume IV. BPAS User’s Guide: Analysis Module SURVY2.

Science.gov (United States)

1982-06-01

feet NSL), the shoreline position can be extrapolated using the two sawardmost points. Before computing volume changes, comon bonds are established...computer. Such features include the 10- character, 60-bit word size, the FORTRAN- callable sort routine (interfacing with the NOS or NOS/BE operating

A sputnik IV saga

Science.gov (United States)

Lundquist, Charles A.

2009-12-01

The Sputnik IV launch occurred on May 15, 1960. On May 19, an attempt to deorbit a 'space cabin' failed and the cabin went into a higher orbit. The orbit of the cabin was monitored and Moonwatch volunteer satellite tracking teams were alerted to watch for the vehicle demise. On September 5, 1962, several team members from Milwaukee, Wisconsin made observations starting at 4:49 a.m. of a fireball following the predicted orbit of Sputnik IV. Requests went out to report any objects found under the fireball path. An early morning police patrol in Manitowoc had noticed a metal object on a street and had moved it to the curb. Later the officers recovered the object and had it dropped off at the Milwaukee Journal. The Moonwarch team got the object and reported the situation to Moonwatch Headquarters at the Smithsonian Astrophysical Observatory. A team member flew to Cambridge with the object. It was a solid, 9.49 kg piece of steel with a slag-like layer attached to it. Subsequent analyses showed that it contained radioactive nuclei produced by cosmic ray exposure in space. The scientists at the Observatory quickly recognized that measurements of its induced radioactivity could serve as a calibration for similar measurements of recently fallen nickel-iron meteorites. Concurrently, the Observatory directorate informed government agencies that a fragment from Sputnik IV had been recovered. Coincidently, a debate in the UN Committee on Peaceful Uses of Outer Space involved the issue of liability for damage caused by falling satellite fragments. On September 12, the Observatory delivered the bulk of the fragment to the US Delegation to the UN. Two days later, the fragment was used by US Ambassador Francis Plimpton as an exhibit that the time had come to agree on liability for damage from satellite debris. He offered the Sputnik IV fragment to USSR Ambassador P.D. Morozov, who refused the offer. On October 23, Drs. Alla Massevitch and E.K. Federov of the USSR visited the

Quantifying the Impact of Immediate Reconstruction in Postmastectomy Radiation: A Large, Dose-Volume Histogram-Based Analysis

Energy Technology Data Exchange (ETDEWEB)

Ohri, Nisha [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Cordeiro, Peter G. [Department of Plastic Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Keam, Jennifer [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Ballangrud, Ase [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Shi Weiji; Zhang Zhigang [Department of Biostatistics and Epidemiology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Nerbun, Claire T.; Woch, Katherine M.; Stein, Nicholas F.; Zhou Ying [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); McCormick, Beryl; Powell, Simon N. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Ho, Alice Y., E-mail: HoA1234@mskcc.org [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)

2012-10-01

Purpose: To assess the impact of immediate breast reconstruction on postmastectomy radiation (PMRT) using dose-volume histogram (DVH) data. Methods and Materials: Two hundred forty-seven women underwent PMRT at our center, 196 with implant reconstruction and 51 without reconstruction. Patients with reconstruction were treated with tangential photons, and patients without reconstruction were treated with en-face electron fields and customized bolus. Twenty percent of patients received internal mammary node (IMN) treatment. The DVH data were compared between groups. Ipsilateral lung parameters included V20 (% volume receiving 20 Gy), V40 (% volume receiving 40 Gy), mean dose, and maximum dose. Heart parameters included V25 (% volume receiving 25 Gy), mean dose, and maximum dose. IMN coverage was assessed when applicable. Chest wall coverage was assessed in patients with reconstruction. Propensity-matched analysis adjusted for potential confounders of laterality and IMN treatment. Results: Reconstruction was associated with lower lung V20, mean dose, and maximum dose compared with no reconstruction (all P<.0001). These associations persisted on propensity-matched analysis (all P<.0001). Heart doses were similar between groups (P=NS). Ninety percent of patients with reconstruction had excellent chest wall coverage (D95 >98%). IMN coverage was superior in patients with reconstruction (D95 >92.0 vs 75.7%, P<.001). IMN treatment significantly increased lung and heart parameters in patients with reconstruction (all P<.05) but minimally affected those without reconstruction (all P>.05). Among IMN-treated patients, only lower lung V20 in those without reconstruction persisted (P=.022), and mean and maximum heart doses were higher than in patients without reconstruction (P=.006, P=.015, respectively). Conclusions: Implant reconstruction does not compromise the technical quality of PMRT when the IMNs are untreated. Treatment technique, not reconstruction, is the primary

Guide for the evaluation of physical protection equipment. Book 2: Volumes IV--VIII

International Nuclear Information System (INIS)

Haberman, W.

1977-06-01

A guide for evaluating the performance of commercially available physical protection equipment has been prepared for use by U.S. NRC. Separate evaluation procedures are provided for each generic type of equipment contained in the companion document, Catalog of Physical Protection Equipment (NUREG-0274). Among the equipment parameters evaluated are sensitivity, area/volume of coverage, false/nuisance alarm rate, resistance to countermeasures, environmental requirements, installation parameters and maintenance. Four evaluation techniques are employed (inspections, analyses, demonstrations and tests); standard test equipment (both commercially available as well as developmental) to be used in the evaluation is listed. The following categories of equipment are covered: surveillance and alarm assessment components, contraband detection components, automated response components, general purpose display components, and general purpose communication components

Gulf of Mexico sales 142 and 143: Central and western planning areas. Draft environmental impact statement. Volume 2. Sections IV.D through IX

International Nuclear Information System (INIS)

1992-04-01

The EIS is a description of the environmental aspects and impacts of oil and gas activities resulting from these lease sales or the states bordering the Gulf of Mexico. The report provides a description of the areas, the affected environment, and the environmental consequences; it discusses the proposed actions, issues and areas of concern, and the major differences of holding these lease sales

Gulf of Mexico Sales 142 and 143: Central and western planning areas. Draft environmental impact statement. Volume 1. Sections I through IV.C

International Nuclear Information System (INIS)

1992-04-01

The EIS is a description of the environmental aspects and impacts of oil and gas activities resulting from these lease sales or the states bordering the Gulf of Mexico. The report provides a description of the areas, the affected environment, and the environmental consequences; it discusses the proposed actions, issues and areas of concern, and the major differences of holding these lease sales

The impact of environmental conditions on human performance: A handbood of environmental exposures. Volume 1

International Nuclear Information System (INIS)

Echeverria, D.; Barnes, V.; Bittner, A.

1994-09-01

A comprehensive review of the technical literature was conducted regarding the impact of environmental conditions on hyman performance applicable to nuclear power plant workers. The environmental conditions considered were vibration, noise, heat, cold, and light. Research staff identified potential human performance deficits (e.g., decreased dexterity, impaired vision, hearing loss, memory deficiency) along a continuum of increasing occupational exposure, ranging from exposures that result in no deficit to exposures that resulted in significant performance problems. Specific deficits were included in the report if there was sound scientific evidence that environmental exposure resulted in those performance deficits. The levels associated with each deficit were then compared to the protection afforded by existing occupational exposure standards. Volume 1 is a handbook for use by NRC inspectors to help them determine the impact of specific environmental conditions on licensee personnel performance. it discusses the units used to measure each condition, discusses the effects of the condition on task performance, presents an example of the assessment of each condition in a nuclear power plant, and discusses potential methods for reducing the effects of

Determination of uranium (IV) by flow voltammetry

International Nuclear Information System (INIS)

Ding Anqing

1987-01-01

According to the quantitative reaction of U(IV) and Fe(III) in H 2 SO 4 as well as the relation between current and concentration of substance detected, U(IV) has been determined indirectly by measurement of the electrolysis current of residual Fe(III). The columniform electrode used is made of glass carbon particles. At the range of U(IV) from a few micrograms to 40 μg, the linear relation is excellent. The relative standard deviation is within ±4%. The interference of Fe(II), Ti(IV) and U(VI) is negligible but of Ti(III) is serious. This method has been successfully applied in the determination of actual samples (both out line and on line). Main advantages of this procedure are rapid, simple, small amount of sample (only at microgram level) and easy to realize automation, able to use for on line or process analysis

Structural investigation of oxovanadium(IV) Schiff base complexes: X-ray crystallography, electrochemistry and kinetic of thermal decomposition

Czech Academy of Sciences Publication Activity Database

Asadi, M.; Asadi, Z.; Savaripoor, N.; Dušek, Michal; Eigner, Václav; Shorkaei, M.R.; Sedaghat, M.

2015-01-01

Roč. 136, Feb (2015), 625-634 ISSN 1386-1425 R&D Projects: GA ČR(CZ) GAP204/11/0809 Institutional support: RVO:68378271 Keywords : Oxovanadium(IV) complexes * Schiff base * Kinetic s of thermal decomposition * Electrochemistry Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.653, year: 2015

Testing and economical evaluation of U(IV) in Purex

International Nuclear Information System (INIS)

Hoisington, J.E.; Hsu, T.C.

1983-01-01

The use of uranous nitrate, U(IV), as a plutonium reductant in the Purex solvent extraction process could significantly reduce the waste generation at the Savannah River Plant. The current reductant is a ferrous sulfamate (FS)/hydroxylamine nitrate (HAN) mixture. The iron and sulfate in the FS are major contributors to waste generation. The U(IV) reductant oxidizes to U(VI) producing no waste. The Savannah River Laboratory has developed an efficient electrochemical cell for U(IV) production and has demonstrated the effectiveness of U(IV) as a plutonium reductant. Plant tests and economic analyses are currently being conducted to determine the cost effectiveness of U(IV) implementation. The results of recent studies are presented

Prognostic Impact of 21-Gene Recurrence Score in Patients With Stage IV Breast Cancer: TBCRC 013.

Science.gov (United States)

King, Tari A; Lyman, Jaclyn P; Gonen, Mithat; Voci, Amy; De Brot, Marina; Boafo, Camilla; Sing, Amy Pratt; Hwang, E Shelley; Alvarado, Michael D; Liu, Minetta C; Boughey, Judy C; McGuire, Kandace P; Van Poznak, Catherine H; Jacobs, Lisa K; Meszoely, Ingrid M; Krontiras, Helen; Babiera, Gildy V; Norton, Larry; Morrow, Monica; Hudis, Clifford A

2016-07-10

The objective of this study was to determine whether the 21-gene Recurrence Score (RS) provides clinically meaningful information in patients with de novo stage IV breast cancer enrolled in the Translational Breast Cancer Research Consortium (TBCRC) 013. TBCRC 013 was a multicenter prospective registry that evaluated the role of surgery of the primary tumor in patients with de novo stage IV breast cancer. From July 2009 to April 2012, 127 patients from 14 sites were enrolled; 109 (86%) patients had pretreatment primary tumor samples suitable for 21-gene RS analysis. Clinical variables, time to first progression (TTP), and 2-year overall survival (OS) were correlated with the 21-gene RS by using log-rank, Kaplan-Meier, and Cox regression. Median patient age was 52 years (21 to 79 years); the majority had hormone receptor-positive/human epidermal growth factor receptor 2 (HER2)-negative (72 [66%]) or hormone receptor-positive/HER2-positive (20 [18%]) breast cancer. At a median follow-up of 29 months, median TTP was 20 months (95% CI, 16 to 26 months), and median survival was 49 months (95% CI, 40 months to not reached). An RS was generated for 101 (93%) primary tumor samples: 22 (23%) low risk (< 18), 29 (28%) intermediate risk (18 to 30); and 50 (49%) high risk (≥ 31). For all patients, RS was associated with TTP (P = .01) and 2-year OS (P = .04). In multivariable Cox regression models among 69 patients with estrogen receptor (ER)-positive/HER2-negative cancer, RS was independently prognostic for TTP (hazard ratio, 1.40; 95% CI, 1.05 to 1.86; P = .02) and 2-year OS (hazard ratio, 1.83; 95% CI, 1.14 to 2.95; P = .013). The 21-gene RS is independently prognostic for both TTP and 2-year OS in ER-positive/HER2-negative de novo stage IV breast cancer. Prospective validation is needed to determine the potential role for this assay in the clinical management of this patient subset. © 2016 by American Society of Clinical Oncology.

Are stage IV vestibular schwannomas preoperatively different from other stages?

Science.gov (United States)

Tringali, Stéphane; Dubreuil, Christian; Zaouche, Sandra; Ferber-Viart, Chantal

2008-01-01

The aim of this study was to focus on the clinical and paraclinical symptoms of patients suffering from Stage IV vestibular schwannomas (VSs). In this prospective study, we included 734 patients who have VS and candidates for operation. Patients were classified as having Stage I, II, III, or IV tumors according to Tos criteria as evaluated by magnetic resonance imaging. PREOPERATIVE CLINICAL EVALUATION: We recorded the occurrence of complaints (%) and duration (yr) of hearing loss, tinnitus, and balance disorder. Preoperative paraclinical evaluation included pure-tone (PTA) and speech audiometry, auditory brainstem response (ABR) patterns, and vestibular deficit at videonystamography (VNG). Continuous variables were compared between Stage IV and other stages using analysis of variance. Qualitative variables expressed as a percentage of presence were compared between Stage IV and other stages using percentage comparison. Quantitative Parameters. Patients with Stage IV VS were significantly younger as compared with patients with other stages. Stage IV hearing loss was greater compared with other stages at 250 and 500 Hz but smaller at 2,000 and 8,000 Hz. We found no difference in the loss of PTA between Stage IV and the other stages. Speech discriminancy score was smaller in Stage IV. The durations of hearing loss, tinnitus, and balance disorders were similar whatever the tumor stage. Auditory brainstem response patterns showed no difference in Wave III latency between Stage IV VS and other stages, whereas Wave V latency and V-I interval were higher in Stage IV. Both ABR threshold and VNG caloric deficit were higher in Stage IV VS compared with other stages. Qualitative Parameters. The percentage of patients with Stage IV was lower than that with Stages II and III. The percentage of men and women was similar in all stages. The occurrence of hearing loss was similar in all stages, whereas that of tinnitus was lower in Stage IV compared with Stages I and II. In

COBRA-IV wire wrap data comparisons

International Nuclear Information System (INIS)

Donovan, T.E.; George, T.L.; Wheeler, C.L.

1979-02-01

Thermal hydraulic analyses of hexagonally packed wire-wrapped fuel assemblies are complicated by the induced crossflow between adjacent subchannels. The COBRA-IV computer code simultaneously solves the hydrodynamics and thermodynamics of fuel assemblies. The modifications and the results are presented which are predicted by the COBRA-IV calculation. Comparisons are made with data measured in five experimental models of a wire-wrapped fuel assembly

Blood flow and blood volume in a transplanted rat fibrosarcoma

International Nuclear Information System (INIS)

Tozer, G.M.; Morris, C.C.

1990-01-01

Blood flow measurements following i.v. infusion of iodi-antipyrine labelled with 14 C ( 14 C-IAP) and blood volume measurements following i.v. injection of 125 I human serum albumin and 51 Cr-labelled red blood cells were made in a transplanted rat fibrosarcoma for comparison with various normal tissues. The tumour-blood partition co-efficient for 14 C-IAP w as found to be 0.79 ± 0.07 which is similar to most of the normal tissues studied. The solubility of 14 C-IAP in plasma was found to be higher than that in whole blood. Blood flow to tumours 3 was found to be 17.9 ± 4.0 ml blood 100 g tissue -1 xmin -1 . These values were considered to be primarily measurements of nutritive flow. Blood in the tumours was found to occupy around 1% of the tissue space which was similar to that found for normal muscle and skin. There was no direct correlation between % blood volume and blood flow for the different tissues studied. Th haematocrit of blood contained in tumour tissue was calculated to be significantly lower than that of blood contained in the normal tissues. It was suspected that permeability of tumour blood vessel walls to 125 I-HSA could have accounted for this difference. (author). 41 refs.; 2 figs.; 3 tabs

Age of second language acquisition in multilinguals has an impact on gray matter volume in language-associated brain areas.

Science.gov (United States)

Kaiser, Anelis; Eppenberger, Leila S; Smieskova, Renata; Borgwardt, Stefan; Kuenzli, Esther; Radue, Ernst-Wilhelm; Nitsch, Cordula; Bendfeldt, Kerstin

2015-01-01

Numerous structural studies have established that experience shapes and reshapes the brain throughout a lifetime. The impact of early development, however, is still a matter of debate. Further clues may come from studying multilinguals who acquired their second language at different ages. We investigated adult multilinguals who spoke three languages fluently, where the third language was learned in classroom settings, not before the age of 9 years. Multilinguals exposed to two languages simultaneously from birth (SiM) were contrasted with multinguals who acquired their first two languages successively (SuM). Whole brain voxel based morphometry revealed that, relative to SuM, SiM have significantly lower gray matter volume in several language-associated cortical areas in both hemispheres: bilaterally in medial and inferior frontal gyrus, in the right medial temporal gyrus and inferior posterior parietal gyrus, as well as in the left inferior temporal gyrus. Thus, as shown by others, successive language learning increases the volume of language-associated cortical areas. In brains exposed early on and simultaneously to more than one language, however, learning of additional languages seems to have less impact. We conclude that - at least with respect to language acquisition - early developmental influences are maintained and have an effect on experience-dependent plasticity well into adulthood.

Age of second language acquisition in multilinguals has an impact on grey matter volume in language-associated brain areas

Directory of Open Access Journals (Sweden)

Anelis eKaiser

2015-06-01

Full Text Available Numerous structural studies have established that experience shapes and reshapes the brain throughout a lifetime. The impact of early development, however, is still a matter of debate. Further clues may come from studying multilinguals who acquired their second language at different ages. We investigated adult multilinguals who spoke three languages fluently, where the third language was learned in classroom settings, not before the age of 9 years. Multilinguals exposed to 2 languages simultaneously from birth (SiM were contrasted with multinguals who acquired their first two languages successively (SuM. Whole brain voxel based morphometry revealed that, relative to SuM, SiM have significantly lower grey matter volume in several language-associated cortical areas in both hemispheres: bilaterally in medial and inferior frontal gyrus, in the right medial temporal gyrus and inferior posterior parietal gyrus, as well as in the left inferior frontal gyrus. Thus, as shown by others, successive language learning increases the volume of language-associated cortical areas. In brains exposed early on and simultaneously to more than one language, however, learning of additional languages seems to have less impact. We conclude that - at least with respect to language acquisition - early developmental influences are maintained and influence experience-dependent plasticity well into adulthood.

Determination of the solubility of Np(IV), Pu(III) - (VI),Am(III) - (VI), and Te(IV), (V) hydroxo compounds in 0.5 - 14 M NaOH solutions

Energy Technology Data Exchange (ETDEWEB)

Delegard, C.H.

1996-09-24

The solubilities of Am(III), Np(IV), Pu(IV), Tc(IV), Np(V), Pu(V), Am(V), and Tc(V) hydroxo compounds were studied in 0.5 to 14 M NaOH solutions at 25{+-}2 {degrees}C. The effects of fluoride, phosphate, carbonate, oxalate, and some other organic complexing agents on the solubilities of Np(IV), Pu(IV), and TC(IV) hydroxides were investigated at 1.0 and 4.0 M NAOH. Some predictions were made on the dissolved (I.V) and (V) species present in alkali solutions.

Ehlers-Danlos syndrome type IV

Directory of Open Access Journals (Sweden)

Germain Dominique P

2007-07-01

Full Text Available Abstract Ehlers-Danlos syndrome type IV, the vascular type of Ehlers-Danlos syndromes (EDS, is an inherited connective tissue disorder defined by characteristic facial features (acrogeria in most patients, translucent skin with highly visible subcutaneous vessels on the trunk and lower back, easy bruising, and severe arterial, digestive and uterine complications, which are rarely, if at all, observed in the other forms of EDS. The estimated prevalence for all EDS varies between 1/10,000 and 1/25,000, EDS type IV representing approximately 5 to 10% of cases. The vascular complications may affect all anatomical areas, with a tendency toward arteries of large and medium diameter. Dissections of the vertebral arteries and the carotids in their extra- and intra-cranial segments (carotid-cavernous fistulae are typical. There is a high risk of recurrent colonic perforations. Pregnancy increases the likelihood of a uterine or vascular rupture. EDS type IV is inherited as an autosomal dominant trait that is caused by mutations in the COL3A1 gene coding for type III procollagen. Diagnosis is based on clinical signs, non-invasive imaging, and the identification of a mutation of the COL3A1 gene. In childhood, coagulation disorders and Silverman's syndrome are the main differential diagnoses; in adulthood, the differential diagnosis includes other Ehlers-Danlos syndromes, Marfan syndrome and Loeys-Dietz syndrome. Prenatal diagnosis can be considered in families where the mutation is known. Choriocentesis or amniocentesis, however, may entail risk for the pregnant woman. In the absence of specific treatment for EDS type IV, medical intervention should be focused on symptomatic treatment and prophylactic measures. Arterial, digestive or uterine complications require immediate hospitalisation, observation in an intensive care unit. Invasive imaging techniques are contraindicated. Conservative approach is usually recommended when caring for a vascular

Ehlers-Danlos syndrome type IV

Science.gov (United States)

Germain, Dominique P

2007-01-01

Ehlers-Danlos syndrome type IV, the vascular type of Ehlers-Danlos syndromes (EDS), is an inherited connective tissue disorder defined by characteristic facial features (acrogeria) in most patients, translucent skin with highly visible subcutaneous vessels on the trunk and lower back, easy bruising, and severe arterial, digestive and uterine complications, which are rarely, if at all, observed in the other forms of EDS. The estimated prevalence for all EDS varies between 1/10,000 and 1/25,000, EDS type IV representing approximately 5 to 10% of cases. The vascular complications may affect all anatomical areas, with a tendency toward arteries of large and medium diameter. Dissections of the vertebral arteries and the carotids in their extra- and intra-cranial segments (carotid-cavernous fistulae) are typical. There is a high risk of recurrent colonic perforations. Pregnancy increases the likelihood of a uterine or vascular rupture. EDS type IV is inherited as an autosomal dominant trait that is caused by mutations in the COL3A1 gene coding for type III procollagen. Diagnosis is based on clinical signs, non-invasive imaging, and the identification of a mutation of the COL3A1 gene. In childhood, coagulation disorders and Silverman's syndrome are the main differential diagnoses; in adulthood, the differential diagnosis includes other Ehlers-Danlos syndromes, Marfan syndrome and Loeys-Dietz syndrome. Prenatal diagnosis can be considered in families where the mutation is known. Choriocentesis or amniocentesis, however, may entail risk for the pregnant woman. In the absence of specific treatment for EDS type IV, medical intervention should be focused on symptomatic treatment and prophylactic measures. Arterial, digestive or uterine complications require immediate hospitalisation, observation in an intensive care unit. Invasive imaging techniques are contraindicated. Conservative approach is usually recommended when caring for a vascular complication in a patient suffering

Concordance between DSM-5 and DSM-IV nicotine, alcohol, and cannabis use disorder diagnoses among pediatric patients.

Science.gov (United States)

Kelly, Sharon M; Gryczynski, Jan; Mitchell, Shannon Gwin; Kirk, Arethusa; O'Grady, Kevin E; Schwartz, Robert P

2014-07-01

The recently published Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) includes several major revisions to substance use diagnoses. Studies have evaluated the impact of these changes among adult samples but research with adolescent samples is lacking. 525 adolescents (93% African American) awaiting primary care appointments in Baltimore, Maryland were recruited for a study evaluating a substance use screening instrument. Participants were assessed for DSM-5 nicotine, alcohol, and cannabis use disorder, DSM-IV alcohol and cannabis abuse, and DSM-IV dependence for all three substances during the past year using the modified Composite International Diagnostic Interview-2, Substance Abuse Module. Contingency tables examining DSM-5 vs. DSM-IV joint frequency distributions were examined for each substance. Diagnoses were more prevalent using DSM-5 criteria compared with DSM-IV for nicotine (4.0% vs. 2.7%), alcohol (4.6% vs. 3.8%), and cannabis (10.7% vs. 8.2%). Cohen's κ, Somers' d, and Cramer's V ranged from 0.70 to 0.99 for all three substances. Of the adolescents categorized as "diagnostic orphans" under DSM-IV, 7/16 (43.8%), 9/29 (31.0%), and 13/36 (36.1%) met criteria for DSM-5 disorder for nicotine, alcohol, and cannabis, respectively. Additionally, 5/17 (29.4%) and 1/21 (4.8%) adolescents who met criteria for DSM-IV abuse did not meet criteria for a DSM-5 diagnosis for alcohol and cannabis, respectively. Categorizing adolescents using DSM-5 criteria may result in diagnostic net widening-particularly for cannabis use disorders-by capturing adolescents who were considered diagnostic orphans using DSM-IV criteria. Future research examining the validity of DSM-5 substance use disorders with larger and more diverse adolescent samples is needed. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Gen IV Materials Handbook Implementation Plan

International Nuclear Information System (INIS)

Rittenhouse, P.; Ren, W.

2005-01-01

A Gen IV Materials Handbook is being developed to provide an authoritative single source of highly qualified structural materials information and materials properties data for use in design and analyses of all Generation IV Reactor Systems. The Handbook will be responsive to the needs expressed by all of the principal government, national laboratory, and private company stakeholders of Gen IV Reactor Systems. The Gen IV Materials Handbook Implementation Plan provided here addresses the purpose, rationale, attributes, and benefits of the Handbook and will detail its content, format, quality assurance, applicability, and access. Structural materials, both metallic and ceramic, for all Gen IV reactor types currently supported by the Department of Energy (DOE) will be included in the Gen IV Materials Handbook. However, initial emphasis will be on materials for the Very High Temperature Reactor (VHTR). Descriptive information (e.g., chemical composition and applicable technical specifications and codes) will be provided for each material along with an extensive presentation of mechanical and physical property data including consideration of temperature, irradiation, environment, etc. effects on properties. Access to the Gen IV Materials Handbook will be internet-based with appropriate levels of control. Information and data in the Handbook will be configured to allow search by material classes, specific materials, specific information or property class, specific property, data parameters, and individual data points identified with materials parameters, test conditions, and data source. Details on all of these as well as proposed applicability and consideration of data quality classes are provided in the Implementation Plan. Website development for the Handbook is divided into six phases including (1) detailed product analysis and specification, (2) simulation and design, (3) implementation and testing, (4) product release, (5) project/product evaluation, and (6) product

Construction and operation of the Spallation Neutron Source: Draft environmental impact statement. Volume 2

International Nuclear Information System (INIS)

1998-12-01

DOE proposes to construct and operate a state-of-the-art, short-pulsed spallation neutron source comprised of an ion source, a linear accelerator, a proton accumulator ring, and an experiment building containing a liquid mercury target and a suite of neutron scattering instrumentation. The proposed Spallation Neutron Source would be designed to operate at a proton beam power of 1 megawatt. The design would accommodate future upgrades to a peak operating power of 4 megawatts. These upgrades may include construction of a second proton accumulation ring and a second target. Volume 1 of this document analyzes the potential environmental impacts from the proposed action and the alternatives. The analysis assumes a facility operating at a power of 1 MW and 4 MW over the life of the facility. The two primary alternatives analyzed in this EIS are: the proposed action (to proceed with building the Spallation Neutron Source) and the No-Action Alternative. This volume contains the following appendices: (A) SNS accident source terms for EIS input; (B) Reports on the selection of alternative sites for the SNS; (C) Letters of consultation on protected species and cultural resources; (D) Ecological resource survey reports and summaries; (E) Descriptions of ORNL research projects in the Walker Branch Watershed; (F) Atmospheric dispersion and dose calculations for normal and accident conditions; (G) Projected air quality modeling effects at NOAA's Walker Branch Monitoring Tower

Independent Examination of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV): What Does the WAIS-IV Measure?

Science.gov (United States)

Benson, Nicholas; Hulac, David M.; Kranzler, John H.

2010-01-01

Published empirical evidence for the Wechsler Adult Intelligence Scale--Fourth Edition (WAIS-IV) does not address some essential questions pertaining to the applied practice of intellectual assessment. In this study, the structure and cross-age invariance of the latest WAIS-IV revision were examined to (a) elucidate the nature of the constructs…

Overburden characterization and post-burn study of the Hanna IV, underground coal gasification site, Wyoming, and comparison to other Wyoming UCG sites

Energy Technology Data Exchange (ETDEWEB)

Marcouiller, B.A.; Burns, L.K.; Ethridge, F.G.

1984-11-01

Analysis of 21 post-burn cores taken from the Hanna IV UCG site allows 96 m (315 ft) of overburden to be subdivided into four local stratigraphic units. The 7.6 m (25 ft) thick Hanna No. 1 coal seam is overlain by a laterally discontinuous, 3.3 m (11 ft) thick shaley mudstone (Unit A') in part of the Hanna IV site. A more widespread, 30 m (90 ft) thick well-indurated sandstone (Unit A) overlies the A' unit. Unit A is the roof rock for both of the Hanna IV cavities. Overlying Unit A is a 33 m (108 ft) thick sequence of mudstone and claystone (Unit B), and the uppermost unit at the Hanna IV site (Unit C) is a coarse-grained sandstone that ranges in thickness from 40 to 67 m (131 to 220 ft). Two elliptical cavities were formed during the two phases of the Hanna IV experiment. The larger cavity, Hanna IVa, is 45 x 15 m in plan and has a maximum height of 18 m (59 ft) from the base of the coal seam to the top of the cavity; the Hanna IVb cavity is 40 x 15 m in plan and has a maximum height of 11 m (36 ft) from the base of the coal seam to the top of the cavity. Geotechnical tests indicated that the Hanna IV overburden rocks were moderately strong to strong, based on the empirical classification of Broch and Franklin (1972), and a positive, linear correlation exists between rock strength and volume percent calcite cement. There is an inverse linear correlation between rock strength and porosity for the Hanna IV overburden rocks. 28 refs., 34 figs., 13 tabs..

Impacted science: impact is not importance.

Science.gov (United States)

Casadevall, Arturo; Fang, Ferric C

2015-10-13

The journal impact factor (IF) exerts a tremendous influence on the conduct of scientists. The obsession with IF has been compared to a medical condition, sometimes referred to as "IF mania" or "impactitis." Here, we analyze the difference between impact and importance, using examples from the history of science to show that these are not equivalent. If impact does not necessarily equal importance, but scientists are focused on high-impact work, there is a danger that misuse of the IF may adversely affect scientific progress. We suggest five measures to fight this malady: (i) diversify journal club selections, (ii) do not judge science on the publication venue, (iii) reduce the reliance on journal citation metrics for employment and advancement, (iv) discuss the misuse of the IF in ethics courses, and (v) cite the most appropriate sources. If IF mania is indeed a medical condition, the most appropriate course of action may be disimpaction. Copyright © 2015 Casadevall and Fang.

Waste isolation in the U.S., technical programs and public education. Volume 2 - low level waste, volume reduction methodologies and economics. Vol. 2

International Nuclear Information System (INIS)

Post, R.G.

1984-01-01

This volume presents information regarding low-level waste, volume reduction methodologies and economics. Topics include: public education on nuclear waste; economics of low-level waste management systems; operating experience with advanced volume reduction techniques; solidification of waste; operating experience with advanced volume reduction techniques--incineration; regional plans for the disposal of low-level waste; radwaste system modifications at nuclear power plants; operating experience with advanced volume reduction techniques--operations and on-site storage issues; and economic impact of 10CFR61

The Materials Science and its impact in the Archaeology- Volume 2

International Nuclear Information System (INIS)

Mendoza A, D.; Arenas A, J.A.; Rodriguez L, V.

2005-01-01

This book seeks to gather the different investigations carried out in the context of the materials science guided to the archaeometry, presented in the 'International Congress of Materials 2004', looking for with it to facilitate the knowledge transfer related with the application of the modern nuclear analytical techniques for the materials characterization as, X-ray diffraction, Scanning Electron Microscopy, Absorption spectroscopy, PIXE analysis, X-ray fluorescence analysis among other techniques to understand with a bigger depth the characteristics and properties of the materials used in diverse activities in the different stages of the humanity, there have been characterized materials as ceramics, metals, polymers, biomaterials, composite materials, pigments, nano structured materials. Since the articles here presented are of quality and its approach each topic with an original vision, this volume 2 of the book 'The Science of Materials and their Impact in the Archaeology' it will woke up the interest of a wide number of investigators, and that the different presented topics allow to visualize that this methods and techniques here approached its represent powerful tools, to enlarge our knowledge on the different cultures that preceded us. (Author)

High volume hydraulic fracturing operations: potential impacts on surface water and human health.

Science.gov (United States)

Mrdjen, Igor; Lee, Jiyoung

2016-08-01

High volume, hydraulic fracturing (HVHF) processes, used to extract natural gas and oil from underground shale deposits, pose many potential hazards to the environment and human health. HVHF can negatively affect the environment by contaminating soil, water, and air matrices with potential pollutants. Due to the relatively novel nature of the process, hazards to surface waters and human health are not well known. The purpose of this article is to link the impacts of HVHF operations on surface water integrity, with human health consequences. Surface water contamination risks include: increased structural failure rates of unconventional wells, issues with wastewater treatment, and accidental discharge of contaminated fluids. Human health risks associated with exposure to surface water contaminated with HVHF chemicals include increased cancer risk and turbidity of water, leading to increased pathogen survival time. Future research should focus on modeling contamination spread throughout the environment, and minimizing occupational exposure to harmful chemicals.

Generation IV nuclear reactors: Current status and future prospects

International Nuclear Information System (INIS)

Locatelli, Giorgio; Mancini, Mauro; Todeschini, Nicola

2013-01-01

Generation IV nuclear power plants (GEN IV NPPs) are supposed to become, in many countries, an important source of base load power in the middle–long term (2030–2050). Nowadays there are many designs of these NPPs but for political, strategic and economic reasons only few of them will be deployed. International literature proposes many papers and reports dealing with GEN IV NPPs, but there is an evident difference in the types and structures of the information and a general unbiased overview is missing. This paper fills the gap, presenting the state-of-the-art for GEN IV NPPs technologies (VHTR, SFR, SCWR, GFR, LFR and MSR) providing a comprehensive literature review of the different designs, discussing the major R and D challenges and comparing them with other advanced technologies available for the middle- and long-term energy market. The result of this research shows that the possible applications for GEN IV technologies are wider than current NPPs. The economics of some GEN IV NPPs is similar to actual NPPs but the “carbon cost” for fossil-fired power plants would increase the relative valuation. However, GEN IV NPPs still require substantial R and D effort, preventing short-term commercial adoption. - Highlights: • Generation IV reactors are the middle–long term technology for nuclear energy. • This paper provides an overview and a taxonomy for the designs under consideration. • R and D efforts are in the material, heat exchangers, power conversion unit and fuel. • The life cycle costs are competitive with other innovative technologies. • The hydrogen economy will foster the development of Generation IV reactors

IVS Organization

Science.gov (United States)

2004-01-01

International VLBI Service (IVS) is an international collaboration of organizations which operate or support Very Long Baseline Interferometry (VLBI) components. The goals are: To provide a service to support geodetic, geophysical and astrometric research and operational activities. To promote research and development activities in all aspects of the geodetic and astrometric VLBI technique. To interact with the community of users of VLBI products and to integrate VLBI into a global Earth observing system.

Modeling the economics of LLW volume reduction

International Nuclear Information System (INIS)

Voth, M.H.; Witzig, W.F.

1986-01-01

Generators of low-level (radioactive) waste (LLW) are under pressure to implement volume reduction (VR) programs for political and economic reasons. Political reasons include the appearance of generating less waste or meeting quotas. Economic reasons include avoiding high disposal costs and associated surcharges. Volume reduction results in less total volume over which fixed disposal costs are allocated and therefore higher unit costs for disposal. As numerous small compacts are developed, this often overlooked effect becomes more pronounced. The described model presents two unique significant features. First, a feedback loop considers the impact of VR on disposal rates, and second, it appeals to logic without extensive knowledge of VR technology or computer modeling. The latter feature is especially useful in conveying information to students and nontechnical decision makers, demonstrating the impact of each of a complicated set of variables with reproducible results

Independent examination of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV): what does the WAIS-IV measure?

Science.gov (United States)

Benson, Nicholas; Hulac, David M; Kranzler, John H

2010-03-01

Published empirical evidence for the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) does not address some essential questions pertaining to the applied practice of intellectual assessment. In this study, the structure and cross-age invariance of the latest WAIS-IV revision were examined to (a) elucidate the nature of the constructs measured and (b) determine whether the same constructs are measured across ages. Results suggest that a Cattell-Horn-Carroll (CHC)-inspired structure provides a better description of test performance than the published scoring structure does. Broad CHC abilities measured by the WAIS-IV include crystallized ability (Gc), fluid reasoning (Gf), visual processing (Gv), short-term memory (Gsm), and processing speed (Gs), although some of these abilities are measured more comprehensively than are others. Additionally, the WAIS-IV provides a measure of quantitative reasoning (QR). Results also suggest a lack of cross-age invariance resulting from age-related differences in factor loadings. Formulas for calculating CHC indexes and suggestions for interpretation are provided. PsycINFO Database Record (c) 2010 APA, all rights reserved.

Synthesis and Crystal Structures of Dimethylsilylene-Bridged (Amidocyclopentadienyl)Dichlorotitanium(IV) Complexes with Various Substituents on the Cyclopentadienyl Ligand

Czech Academy of Sciences Publication Activity Database

Zemánek, Jaroslav; Štěpnička, P.; Fejfarová, K.; Gyepes, R.; Císařová, I.; Horáček, Michal; Kubišta, Jiří; Varga, V.; Mach, Karel

2001-01-01

Roč. 66, č. 4 (2001), s. 605-620 ISSN 0010-0765 R&D Projects: GA AV ČR IBS4040017 Institutional research plan: CEZ:AV0Z4040901 Keywords : titanium * (amidocyclopentadienyl)dichlorotitanium(IV) complexes * substituent effects Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 0.778, year: 2001

Industrial Waste Landfill IV upgrade package

International Nuclear Information System (INIS)

1994-01-01

The Y-12 Plant, K-25 Site, and ORNL are managed by DOE's Operating Contractor (OC), Martin Marietta Energy Systems, Inc. (Energy Systems) for DOE. Operation associated with the facilities by the Operating Contractor and subcontractors, DOE contractors and the DOE Federal Building result in the generation of industrial solid wastes as well as construction/demolition wastes. Due to the waste streams mentioned, the Y-12 Industrial Waste Landfill IV (IWLF-IV) was developed for the disposal of solid industrial waste in accordance to Rule 1200-1-7, Regulations Governing Solid Waste Processing and Disposal in Tennessee. This revised operating document is a part of a request for modification to the existing Y-12 IWLF-IV to comply with revised regulation (Rule Chapters 1200-1-7-.01 through 1200-1-7-.08) in order to provide future disposal space for the ORR, Subcontractors, and the DOE Federal Building. This revised operating manual also reflects approved modifications that have been made over the years since the original landfill permit approval. The drawings referred to in this manual are included in Drawings section of the package. IWLF-IV is a Tennessee Department of Environmental and Conservation/Division of Solid Waste Management (TDEC/DSWM) Class 11 disposal unit

IVS: Current Status and Future Plans

Science.gov (United States)

Behrend, D.; Nothnagel, A.; Petrachenko, W. T.; Tuccari, G.

2016-12-01

The International VLBI Service for Geodesy and Astrometry (IVS) is a globally operating service that coordinates and performs Very Long Baseline Interferometry (VLBI) activities through its constituent components. The VLBI activities are associated with the creation, provision, dissemination, and archiving of relevant VLBI data and products. The products mostly pertain to the determination of the celestial and terrestrial reference frames, the Earth orientation parameters (EOP), atmospheric parameters as well as other ancillary parameters. The IVS observational network currently consists of about 40 radio telescopes worldwide. Subsets of these telescopes (8-12 stations) participate in 24-hour observing sessions that are run several times per week and in 1-hour intensive sessions for UT1 determination every day. The current VLBI network was developed mainly in the 1970s and 1980s. A number of factors, including aging infrastructure and demanding new scientific requirements, started to challenge its future sustainability and relevance. In response, the IVS and other groups developed and started implementing the next generation VLBI system, called VGOS (VLBI Global Observing System), at existing and new sites. The VGOS network is expected to reach maturity in the early 2020s. We describe the current status, progress, and anticipated prospects of geodetic/astrometric VLBI and the IVS.

Initial Northwest Power Act Power Sales Contracts : Final Environmental Impact Statement. Volume 4, Comments and Responses.

Energy Technology Data Exchange (ETDEWEB)

United States. Bonneville Power Administration.

1992-01-01

This volume of the Initial Northwest Power Act Power Sales Contracts Final Environmental Impact Statement (Final EIS) contains public comments addressing the Initial Northwest Power Act Power Sales Contracts Draft EIS, August 1990 and Bonneville Power Administration`s (BPA) responses. The Introduction provides information about the process BPA follows in addressing these comments. Part I contains a listing of the Alternative Actions evaluated in the Final EIS; Part II is organized by Alternatives and includes summaries of the comments and BPA responses; Part III provides copies of the original comments letters, and, for ease of identification, are coded in the margins according to the alternative(s) addressed.

Draft Programmatic Environmental Impact Statement for alternative strategies for the long-term management and use of depleted uranium hexafluoride. Volume 2: Appendices

International Nuclear Information System (INIS)

1997-12-01

This PEIS assesses the potential impacts of alternative management of alternative management strategies for depleted uranium hexafluoride (UF 6 ) currently stored at three DOE sites: Paducah site near Paducah, Kentucky; Portsmouth site near Portsmouth, Ohio; and K-25 site on the Oak Ridge Reservation, Oak Ridge, Tennessee. The alternatives analyzed in the PEIS include no action, long-term storage as UF 6 , long-term storage as uranium oxide, use as uranium oxide, use as uranium metal, and disposal. The preferred alternative for the long-term management of depleted UF 6 is to use the entire inventory of material. This volume contains the appendices to volume I

Physiology of cell volume regulation in vertebrates

DEFF Research Database (Denmark)

Hoffmann, Else K; Lambert, Ian H; Pedersen, Stine F

2009-01-01

and their regulation by, e.g., membrane deformation, ionic strength, Ca(2+), protein kinases and phosphatases, cytoskeletal elements, GTP binding proteins, lipid mediators, and reactive oxygen species, upon changes in cell volume. We also discuss the nature of the upstream elements in volume sensing in vertebrate...... organisms. Importantly, cell volume impacts on a wide array of physiological processes, including transepithelial transport; cell migration, proliferation, and death; and changes in cell volume function as specific signals regulating these processes. A discussion of this issue concludes the review.......The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a wide array of signaling events, leading to protective (e.g., cytoskeletal rearrangement) and adaptive (e.g., altered expression of osmolyte transporters and heat shock proteins) measures and, in most...

Advanced Computational Materials Science: Application to Fusion and Generation IV Fission Reactors (Workshop Report)

Energy Technology Data Exchange (ETDEWEB)

Stoller, RE

2004-07-15

presented during the workshop apply equally to both types of nuclear energy systems. The primary factor that differentiates the materials development path for the two systems is that nearly prototypical irradiation environments for Gen-IV materials can be found or built in existing fission reactors. This is not the case for fusion. The only fusion-relevant, 14 MeV neutron sources ever built (such as the rotating target neutron sources, RTNS-I and -II at LLNL) were relatively low-power accelerator based systems. The RTNS-II ''high'' flux irradiation volume was quite small, less than 1 cm{sup 3}, and only low doses could be achieved. The maximum dose data obtained was much less than 0.1 dpa. Thus, RTNS-II, which last operated in 1986, provided only a limited opportunity for fundamental investigations of the effects of 14 MeV neutrons characteristic of DT fusion.

Zirconium (IV) complexes with some polymethylenediimines | Na ...

African Journals Online (AJOL)

The syntheses of zirconium (IV) complexes have been carried out by the reaction of oxozirconium (IV) chloride with the appropriate diimines (Schiff bases). The complexes were isolated as yellow solids which are stable to heat. The complexes were found to be insoluble in most solvents. The infrared spectra, elemental ...

Development of Electromagnetic Analysis Model for IV-CEAPI

Energy Technology Data Exchange (ETDEWEB)

Park, Jinseok; Jang, Yongtae; Lee, Myounggoo; Cho, Yeonho; Kim, Hyunmin [KEPCO Engineering and Construction, Inc., Daejeon (Korea, Republic of); Hong, Hoonbin; Baek, Minho [Woojin Inc., Osan (Korea, Republic of)

2016-05-15

There are many different types of position indicators such as reed switch type, ultrasonic type, solenoid type, etc. Through an analysis of strengths and weakness of those types, solenoid type was selected for an IV-CEAPI. Although solenoid type CEAPIs have been used world-wide, the IV-CEAPI is to be very different from the conventional designs due to its harsh operating environment. The concept of the IV-CEAPI is simple as shown in Figure 1. The coil is made of mineral insulated wire to be able to operate inside reactor vessel. The CEA is connected to the shaft which is made of ferromagnetic material. As the CEA position varies, the inductance variation is detected by the inductance meter located outside the vessel. Unlike the conventional ones, the IV-CEAPI used only one coil to eliminate coil connection point and electric components inside vessel. A finite element model was developed to calculate inductance of the solenoid type IV-CEAPI. The model considers eddy current effect to calculate frequency dependent inductance value. Analyses were performed to produce an inductance curve to the shaft position.

Development of Electromagnetic Analysis Model for IV-CEAPI

International Nuclear Information System (INIS)

Park, Jinseok; Jang, Yongtae; Lee, Myounggoo; Cho, Yeonho; Kim, Hyunmin; Hong, Hoonbin; Baek, Minho

2016-01-01

There are many different types of position indicators such as reed switch type, ultrasonic type, solenoid type, etc. Through an analysis of strengths and weakness of those types, solenoid type was selected for an IV-CEAPI. Although solenoid type CEAPIs have been used world-wide, the IV-CEAPI is to be very different from the conventional designs due to its harsh operating environment. The concept of the IV-CEAPI is simple as shown in Figure 1. The coil is made of mineral insulated wire to be able to operate inside reactor vessel. The CEA is connected to the shaft which is made of ferromagnetic material. As the CEA position varies, the inductance variation is detected by the inductance meter located outside the vessel. Unlike the conventional ones, the IV-CEAPI used only one coil to eliminate coil connection point and electric components inside vessel. A finite element model was developed to calculate inductance of the solenoid type IV-CEAPI. The model considers eddy current effect to calculate frequency dependent inductance value. Analyses were performed to produce an inductance curve to the shaft position

The affinity plutonium(IV) for nitrogen donor ligands

International Nuclear Information System (INIS)

Jarvis, N.V.; Hancock, R.D.

1994-01-01

Established ligand design principles are used to predict the solution chemistry of Pu(IV) with nitrogen donor ligands which do not contain carboxylate donors. pK a 's of the nitrogen donors are lowered by addition of hydroxyalkyl groups causing Pu(IV) to have a greater affinity for these ligands than for hydroxide. Potentiometric studies using the ligands N,N,N'N',N''-pentakis(2-hydroxypropyl)-1,4,7-triazaheptane; N,N,N',N',N''-pentakis(2-hydroxyethyl)-1,4,7-triazaheptane; N,N,N',N',N'-tetrakis(2-hydroxyethyl)-1,2-diaminoethane; N,N,N',N'-tetrakis(2-hydroxyethyl)-trans-1,2-diaminocyclohexane; 1,4,8,11-tetrakis(2-hydroxyethyl)-1,4,8,11-tetraazacyclotetradecane and N,N-bis(2-hydroxyethyl)glycine with Pu(IV) showed that Pu(IV) has a considerable aqueous solution chemistry with these ligands. Data were processed by the ESTA library of programs and stability constants for all the systems are reported. Implications for selective ligand design for Pu(IV) are discussed. (orig.)

NNDSS - Table IV. Tuberculosis

Data.gov (United States)

U.S. Department of Health & Human Services — NNDSS - Table IV. Tuberculosis - 2016.This Table includes total number of cases reported in the United States, by region and by states, in accordance with the...

NNDSS - Table IV. Tuberculosis

Data.gov (United States)

U.S. Department of Health & Human Services — NNDSS - Table IV. Tuberculosis - 2014.This Table includes total number of cases reported in the United States, by region and by states, in accordance with the...

NNDSS - Table IV. Tuberculosis

Data.gov (United States)

U.S. Department of Health & Human Services — NNDSS - Table IV. Tuberculosis - 2015.This Table includes total number of cases reported in the United States, by region and by states, in accordance with the...

DSM-IV: a nosology sold before its time?

Science.gov (United States)

Zimmerman, M; Jampala, V C; Sierles, F S; Taylor, M A

1991-04-01

The purpose of this study was to determine whether American psychiatrists believe that DSM-IV is being published too soon after DSM-III-R. The authors conducted a mail survey of the attitudes of practicing psychiatrists (N = 454), residency program directors (N = 128), residents (N = 1,331), and researchers (N = 196) toward the scheduled publication of DSM-IV in the early 1990s. They found that the majority of all four groups believed that DSM-IV is being published prematurely. In contrast to respondents who believed that the timing of DSM-IV is appropriate, those who indicated that it is being published too soon had more recently completed their residency training and also believed that DSM-III-R was published prematurely. There was no association between the psychiatrists' responses and their theoretical orientation, Board certification status, ownership of the DSM manuals, the length of time they had used DSM-III, and the diagnostic manual (DSM-III or DSM-III-R) they were currently using. The belief that DSM-IV is being published too soon could contribute to underuse of DSM-IV by substantial numbers of psychiatrists. Thus, to foster compliance with it, APA must preserve in its efforts to demonstrate that the advantages of publishing it in 1993 outweigh the disadvantages of adopting yet another manual.

Oxovanadium(IV)-catalysed oxidation of dibenzothiophene and 4,6-dimethyldibenzothiophene.

Science.gov (United States)

Ogunlaja, Adeniyi S; Chidawanyika, Wadzanai; Antunes, Edith; Fernandes, Manuel A; Nyokong, Tebello; Torto, Nelson; Tshentu, Zenixole R

2012-12-07

The reaction between [V(IV)OSO(4)] and the tetradentate N(2)O(2)-donor Schiff base ligand, N,N-bis(o-hydroxybenzaldehyde)phenylenediamine (sal-HBPD), obtained by the condensation of salicylaldehyde and o-phenylenediamine in a molar ratio of 2 : 1 respectively, resulted in the formation of [V(IV)O(sal-HBPD)]. The molecular structure of [V(IV)O(sal-HBPD)] was determined by single crystal X-ray diffraction, and confirmed the distorted square pyramidal geometry of the complex with the N(2)O(2) binding mode of the tetradentate ligand. The formation of the polymer-supported p[V(IV)O(sal-AHBPD)] proceeded via the nitrosation of sal-HBPD, followed by the reduction with hydrogen to form an amine group that was then linked to Merrifield beads followed by the reaction with [V(IV)OSO(4)]. XPS and EPR were used to confirm the presence of oxovanadium(IV) within the beads. The BET surface area and porosity of the heterogeneous catalyst p[V(IV)O(sal-AHBPD)] were found to be 6.9 m(2) g(-1) and 180.8 Å respectively. Microanalysis, TG, UV-Vis and FT-IR were used for further characterization of both [V(IV)O(sal-HBPD)] and p[V(IV)O(sal-AHBPD)]. Oxidation of dibenzothiophene (DBT) and 4,6-dimethyldibenzothiophene (4,6-DMDBT) was investigated using [V(IV)O(sal-HBPD)] and p[V(IV)O(sal-AHBPD)] as catalysts. Progress for oxidation of these model compounds was monitored with a gas chromatograph fitted with a flame ionization detector. The oxidation products were characterized using gas chromatography-mass spectrometry, microanalysis and NMR. Dibenzothiophene sulfone (DBTO(2)) and 4,6-dimethyldibenzothiophene sulfone (4,6-DMDBTO(2)) were found to be the main products of oxidation. Oxovanadium(IV) Schiff base microspherical beads, p[V(IV)O(sal-AHBPD)], were able to catalyse the oxidation of sulfur in dibenzothiophene (DBT) and 4,6-dimethyldibenzothiophene (4,6-DMDBT) to a tune of 88.0% and 71.8% respectively after 3 h at 40 °C. These oxidation results show promise for potential application

Surplus plutonium disposition draft environmental impact statement. Volume 1, Part B

International Nuclear Information System (INIS)

1998-07-01

On May 22, 1997, DOE published a Notice of Intent (NOI) in the Federal Register (62 Federal Register 28009) announcing its decision to prepare an environmental impact statement (EIS) that would tier from the analysis and decisions reached in connection with the Storage and Disposition of Weapons-Usable Fissile Materials Final Programmatic EIS (Storage and Disposition PEIS). DOE's disposition strategy allows for both the immobilization of surplus plutonium and its use as mixed oxide (MOX) fuel in existing domestic, commercial reactors. The disposition of surplus plutonium would also involve disposal of the immobilized plutonium and MOX fuel (as spent nuclear fuel) in a geologic repository. The Surplus Plutonium Disposition Environmental Impact Statement analyzes alternatives that would use the immobilization approach (for some of the surplus plutonium) and the MOX fuel approach (for some of the surplus plutonium); alternatives that would immobilize all of the surplus plutonium; and the No Action Alternative. The alternatives include three disposition facilities that would be designed so that they could collectively accomplish disposition of up to 50 metric tons (55 tons) of surplus plutonium over their operating lives: (1) the pit disassembly and conversion facility would disassemble pits (a weapons component) and convert the recovered plutonium, as well as plutonium metal from other sources, into plutonium dioxide suitable for disposition; (2) the immobilization facility would include a collocated capability for converting nonpit plutonium materials into plutonium dioxide suitable for immobilization and would be located at either Hanford or SRS. DOE has identified SRS as the preferred site for an immobilization facility; (3) the MOX fuel fabrication facility would fabricate plutonium dioxide into MOX fuel. This volume has chapters on environmental consequences; environmental regulations, permits, and consultations; a glossary; list of preparers; distribution list

Surplus plutonium disposition draft environmental impact statement. Volume 1, Part A

International Nuclear Information System (INIS)

1998-07-01

On May 22, 1997, DOE published a Notice of Intent (NOI) in the Federal Register (62 Federal Register 28009) announcing its decision to prepare an environmental impact statement (EIS) that would tier from the analysis and decisions reached in connection with the Storage and Disposition of Weapons-Usable Fissile Materials Final Programmatic EIS (Storage and Disposition PEIS). DOE's disposition strategy allows for both the immobilization of surplus plutonium and its use as mixed oxide (MOX) fuel in existing domestic, commercial reactors. The disposition of surplus plutonium would also involve disposal of the immobilized plutonium and MOX fuel (as spent nuclear fuel) in a geologic repository. The Surplus Plutonium Disposition Environmental Impact Statement analyzes alternatives that would use the immobilization approach (for some of the surplus plutonium) and the MOX fuel approach (for some of the surplus plutonium); alternatives that would immobilize all of the surplus plutonium; and the No Action Alternative. The alternatives include three disposition facilities that would be designed so that they could collectively accomplish disposition of up to 50 metric tons (55 tons) of surplus plutonium over their operating lives: (1) the pit disassembly and conversion facility would disassemble pits (a weapons component) and convert the recovered plutonium, as well as plutonium metal from other sources, into plutonium dioxide suitable for disposition; (2) the immobilization facility would include a collocated capability for converting nonpit plutonium materials into plutonium dioxide suitable for immobilization and would be located at either Hanford or SRS. DOE has identified SRS as the preferred site for an immobilization facility; (3) the MOX fuel fabrication facility would fabricate plutonium dioxide into MOX fuel. This volume includes background information; purpose of and need for the proposed action; alternatives for disposition of surplus weapons useable plutonium; and

Intenational conference on high-energy physics. Volume 2. Sessions IV to VIII. [Geneva, June 27-July 4, 1979

Energy Technology Data Exchange (ETDEWEB)

1980-02-01

Volume 2 of the conference proceedings contains sessions on hadron physics, charged-lepton physics, the p-p-bar collider at CERN, future European accelerator possibilities, parallel discussion sessions (on high-energy) hadron-induced reactions, deep inelastic phenomena, hadron spectroscopy, weak ineractions and gauge theories, and quark confinement), and a closing session on gauge appreciation of developments in particle physics. A list of participants is also included. Three of the papers in this volume have already been cited in ERA, and can be found as reference to the entry CONF-790642-- in the Report Number Index. The remaining 36 will be processed as they are received on the Atomindex tape. (RWR)

Niger Republic Mineral Planning : Part IV - first volume : Main mineral substances specific study and their geological context

International Nuclear Information System (INIS)

Franconi, Antoine; Joo', Julien; Zibo, Idde

1981-01-01

This volume contains the detailed study of mineral substances industrially exploited to date : uranium, coal, non metallic building materials and public activities, and non conventionally exploited substances, that are : tin, columbite-tantalite, tungsten, gold, phosphates and evaporates [fr

Dsm-iv hypochondriasis in primary care

OpenAIRE

Escobar, JI; Gara, M; Waitzkin, H; Silver, RC; Holman, A; Compton, W

1998-01-01

The object of this study was to assess the prevalence and correlates of the DSM-IV diagnosis of hypochondriasis in a primary care setting. A large sample (N = 1456) of primary care users was given a structured interview to make diagnoses of mood, anxiety, and somatoform disorders and estimate levels of disability. The prevalence of hypochondriasis (DSM-IV) was about 3%. Patients with this disorder had higher levels of medically unexplained symptoms (abridged somatization) and were more impair...

Economic evaluation of volume reduction for Defense transuranic waste

International Nuclear Information System (INIS)

Brown, C.M.

1982-03-01

The economics of volume reduction of retrievably stored and newly generated DOE transuranic wastes are evaluated by comparing the costs of reduction of the wastes with the savings possible in transportation and disposal. A general approach to the comparison of TRU waste volume reduction costs and cost savings is developed, an initial set of cost data is established, conclusions to support selecting technologies and facilities for the disposal of DOE transuranic waste are developed. Section I outlines the analysis which considers seven types of volume reduction from incineration and compaction of combustibles to compaction, size reduction, shredding, melting, and decontamination of metals. The study considers the volume reduction of contact-handled, newly generated and retrievably stored DOE transuranic wastes. Section II of this report describes the analytical approach, assumptions, and flow of waste material through sites. Section III presents the waste inventories, disposal and transportation savings, and volume reduction techniques and costs. Section IV contains the results and conclusions of the study. The major conclusions drawn from the study are: For DOE sites with a small amount of waste requiring disposal ( 3 /year) the cost of volume reduction is greater than the transportation and disposal savings from volume reduction provided the waste requires little additional preparation to meet transportation and disposal criteria. Wastes that do not meet these criteria require site specific economic analysis outside the general evaluations of this study. For Idaho National Engineering Laboratory, incineration and metal shredding are cost-effective, provided a facility is to be constructed as a consequence of repackaging the fraction of stored waste which may require repackaging and immobilizing chemical process waste to meet disposal criteria

The dependence of C IV broad absorption line properties on accompanying Si IV and Al III absorption: relating quasar-wind ionization levels, kinematics, and column densities

Energy Technology Data Exchange (ETDEWEB)

Filiz Ak, N.; Brandt, W. N.; Schneider, D. P.; Trump, J. R. [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States); Hall, P. B. [Department of Physics and Astronomy, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3 (Canada); Anderson, S. F. [Astronomy Department, University of Washington, Seattle, WA 98195 (United States); Hamann, F. [Department of Astronomy, University of Florida, Gainesville, FL 32611-2055 (United States); Myers, Adam D. [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82071 (United States); Pâris, I. [Departamento de Astronomía, Universidad de Chile, Casilla 36-D, Santiago (Chile); Petitjean, P. [Institut d' Astrophysique de Paris, Universite Paris 6, F-75014 Paris (France); Ross, Nicholas P. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Shen, Yue [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); York, Don, E-mail: nfilizak@astro.psu.edu [Department of Astronomy and Astrophysics, The University of Chicago, Chicago, IL 60637 (United States)

2014-08-20

We consider how the profile and multi-year variability properties of a large sample of C IV Broad Absorption Line (BAL) troughs change when BALs from Si IV and/or Al III are present at corresponding velocities, indicating that the line of sight intercepts at least some lower ionization gas. We derive a number of observational results for C IV BALs separated according to the presence or absence of accompanying lower ionization transitions, including measurements of composite profile shapes, equivalent width (EW), characteristic velocities, composite variation profiles, and EW variability. We also measure the correlations between EW and fractional-EW variability for C IV, Si IV, and Al III. Our measurements reveal the basic correlated changes between ionization level, kinematics, and column density expected in accretion-disk wind models; e.g., lines of sight including lower ionization material generally show deeper and broader C IV troughs that have smaller minimum velocities and that are less variable. Many C IV BALs with no accompanying Si IV or Al III BALs may have only mild or no saturation.

Environmental assessment for operations, upgrades, and modifications in SNL/NM Technical Area IV

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-04-01

The proposed action for this EA for Sandia National Laboratories/New Mexico Technical Area IV, includes continuing existing operations, modification of an existing accelerator (Particle Beam Fusion Accelerator II) to support defnese-related Z-pinch experiments, and construction of two transformer oil storage tanks to support the expansion of the Advanced Pulsed Power Research Module, a single pulse accelerator. Based on the analyses in the EA, DOE believes that the proposed action is not a major federal action significantly affecting the quality of the human environment within the meaning of NEPA and CEQ NEPA implementing regulations in 40 CFR 1508.18 and 1508.27. Therefore, an environmental impact statement is not required, and a Finding of No Significant Impact is issued.

Environmental assessment for operations, upgrades, and modifications in SNL/NM Technical Area IV

International Nuclear Information System (INIS)

1996-04-01

The proposed action for this EA for Sandia National Laboratories/New Mexico Technical Area IV, includes continuing existing operations, modification of an existing accelerator (Particle Beam Fusion Accelerator II) to support defnese-related Z-pinch experiments, and construction of two transformer oil storage tanks to support the expansion of the Advanced Pulsed Power Research Module, a single pulse accelerator. Based on the analyses in the EA, DOE believes that the proposed action is not a major federal action significantly affecting the quality of the human environment within the meaning of NEPA and CEQ NEPA implementing regulations in 40 CFR 1508.18 and 1508.27. Therefore, an environmental impact statement is not required, and a Finding of No Significant Impact is issued

Electrochemical studies of plutonium(IV) complexes in aqueous nitrate solutions

International Nuclear Information System (INIS)

Kim, Seong-Yun; Asakura, Toshihide; Morita, Yasuji

2005-01-01

Electrochemistry has been used to investigate the behavior of plutonium (IV) in 1-7 M HNO 3 solutions. These Pu(IV) complexes were found to be reduced quasi-reversibly to Pu(III) species. The formal redox potentials (E 0 ) for Pu(IV)/Pu(III) couples were determined to be +0.721, +0.712, +0.706, +0.705, +0.704, 0.694, and +0.696 V (vs. Ag/AgCl(SSE)) for Pu(IV) complexes in 1, 2, 3, 4, 5, 6, 7 M HNO 3 solutions, respectively. These results indicate that the reduction product of Pu(IV) is Pu(III), which is considerably stable in HNO 3 solution. (author)

Crystal structure of ammonium octacyanomolybdate(IV) and rubidium octacyanomolybdate(IV)

Energy Technology Data Exchange (ETDEWEB)

Semenishin, D.I.; Glovyak, T.; Mys' kiv, M.G.

1985-11-01

The crystal structure of ammonium octacyanomolybdate(IV) and rubidium octacyanomolybdate(IV) has been determined by the single-crystal method on a Syntex P2/sub 1/ automatic diffractometer: ((NH/sub 4/)/sub 4/ Mo(CN)/sub 4/) 0.5H/sub 2/O (I) (space group Pma2, a = 15.550(3), b = 14.118(3), c = 7.438(1) A, Z = 4, R = 0.062) and Rb/sub 4/(Mo(CN)/sub 8/). 3H/sub 2/O (II) (space group P4/sub 1/2/sub 1/2, a = 9.300(10, c = 21.807(3) A, Z = 4, R = 0.065). The Mo atoms in structure I occupy two special positions (2(b) and 2(c)) and are each surrounded by eight CN ligands. The mean value of the Mo-C distances for Mo(1) is equal to 2.216 A, and the corresponding value for Mo(2) is 2.235 A. The mean Mo-N lengths are practically identical in both molybdenum anions and are equal to 3.353 A. The mean values of the C identical with N bond lengths in the Mo(1) and Mo(2) anions are 1.118 and 1.137 A, respectively. The MoCn angles vary from 175.0 to 178.4/sup 0/. The coordination sphere of the Mo(1) atom corresponds to a dodecahedron with a single twofold symmetry axis, and the coordination polyhedron of the Mo(2) atom in an antiprism of m symmetry. In structure II the Mo-C distances are within the 2.130-2.160-A range, and the Mo-N distances range from 3.290 to 3.307 A. The MoCN angles vary from 176.0 to 179.3/sup 0/, and the coordination polyhedron of (MoC/sub 8/) is a dodecahedron of 2 symmetry. The existence of two types of coordination of Mo in structure I is presently the only example among the structurally studied octahyanomolybdates(IV).

Kinetics of U(VI) reduction control kinetics of U(IV) reoxidation

International Nuclear Information System (INIS)

Senko, J.M.; Minyard, M.L.; Dempsey, B.A.; Roden, E.E.; Yeh, G.-T.; Burgos, W.D.

2006-01-01

For the in situ reductive immobilization of U to be an acceptable strategy for the removal of that element from groundwater, the long-term stability of U(IV) must be determined. Rates of biotransformation of Fe species influence the mineralogy of the resulting products (Fredrickson et al., 2003; Senko et al., 2005), and we hypothesize that the rate of U(VI) reduction influences the mineralogy of resultant U(IV) precipitates. We hypothesize that slower rates of U(VI) reduction will yield U(IV) phases that are more resistant to reoxidation, and will therefore be more stable upon cessation of electron donor addition. U(IV) phases formed by relatively slow reduction may be more crystalline or larger in comparison to their relatively rapidly-formed counterparts (Figure 1), thus limiting the reactivity of slowly-formed U(IV) phases toward various oxidants. The physical location of U(IV) precipitates relative to bacterial cells may also limit the reactivity of biogenic U(IV) phases. In this situation, we expect that precipitation of U(IV) within the bacterial cell may protect U(IV) from reoxidation by limiting physical contact between U(IV) and oxidants (Figure 1). We assessed the effect of U(VI) reduction rate on the subsequent reoxidation of biogenic U(IV) and are currently conducting column scale studies to determine whether U(VI) reduction rate can be manipulated by varying the electron donor concentration used to stimulate U(VI) reduction

Effect of Volume of Fluid Resuscitation on Metabolic Normalization in Children Presenting in Diabetic Ketoacidosis: A Randomized Controlled Trial.

Science.gov (United States)

Bakes, Katherine; Haukoos, Jason S; Deakyne, Sara J; Hopkins, Emily; Easter, Josh; McFann, Kim; Brent, Alison; Rewers, Arleta

2016-04-01

The optimal rate of fluid administration in pediatric diabetic ketoacidosis (DKA) is unknown. Our aim was to determine whether the volume of fluid administration in children with DKA influences the rate of metabolic normalization. We performed a randomized controlled trial conducted in a tertiary pediatric emergency department from December 2007 until June 2010. The primary outcome was time to metabolic normalization; secondary outcomes were time to bicarbonate normalization, pH normalization, overall length of hospital treatment, and adverse outcomes. Children between 0 and 18 years of age were eligible if they had type 1 diabetes mellitus and DKA. Patients were randomized to receive intravenous (IV) fluid at low volume (10 mL/kg bolus + 1.25 × maintenance rate) or high volume (20 mL/kg bolus + 1.5 × maintenance rate) (n = 25 in each). After adjusting for initial differences in bicarbonate levels, time to metabolic normalization was significantly faster in the higher-volume infusion group compared to the low-volume infusion group (hazard ratio [HR] = 2.0; 95% confidence interval [CI] 1.0-3.9; p = 0.04). Higher-volume IV fluid infusion appeared to hasten, to a greater extent, normalization of pH (HR = 2.5; 95% CI 1.2-5.0; p = 0.01) than normalization of serum bicarbonate (HR = 1.2; 95% CI 0.6-2.3; p = 0.6). The length of hospital treatment HR (0.8; 95% CI 0.4-1.5; p = 0.5) and time to discharge HR (0.8; 95% CI 0.4-1.5; p = 0.5) did not differ between treatment groups. Higher-volume fluid infusion in the treatment of pediatric DKA patients significantly shortened metabolic normalization time, but did not change overall length of hospital treatment. ClinicalTrials.gov ID NCT01701557. Copyright © 2016 Elsevier Inc. All rights reserved.

Extended Excluded Volume: Its Origin and Consequences

Czech Academy of Sciences Publication Activity Database

Nezbeda, Ivo; Rouha, M.

2013-01-01

Roč. 85, č. 1 (2013), s. 201-210 ISSN 0033-4545. [International Conference on Solution Chemistry (ICSC-32) /32./. La Grande Motte, 28.08.2011-02.09.2011] R&D Projects: GA AV ČR IAA400720802 Institutional support: RVO:67985858 Keywords : excluded volume * partial molar volume * primitive models Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 3.112, year: 2013

IVS Combination Center at BKG - Robust Outlier Detection and Weighting Strategies

Science.gov (United States)

Bachmann, S.; Lösler, M.

2012-12-01

Outlier detection plays an important role within the IVS combination. Even if the original data is the same for all contributing Analysis Centers (AC), the analyzed data shows differences due to analysis software characteristics. The treatment of outliers is thus a fine line between keeping data heterogeneity and elimination of real outliers. Robust outlier detection based on the Least Median Square (LMS) is used within the IVS combination. This method allows reliable outlier detection with a small number of input parameters. A similar problem arises for the weighting of the individual solutions within the combination process. The variance component estimation (VCE) is used to control the weighting factor for each AC. The Operator-Software-Impact (OSI) method takes into account that the analyzed data is strongly influenced by the software and the responsible operator. It allows to make the VCE more sensitive to the diverse input data. This method has already been set up within GNSS data analysis as well as the analysis of troposphere data. The benefit of an OSI realization within the VLBI combination and its potential in weighting factor determination has not been investigated before.

The carbonate complexation of plutonium(IV)

International Nuclear Information System (INIS)

Hobart, D.E.; Palmer, P.D.; Newton, T.W.

1985-01-01

Plutonium(IV) carbonate complexes are expected to be of particular importance in typical groundwaters at the Yucca Mountain site of the candidate nuclear waste repository being studied by the Nevada Nuclear Waste Storage Investigations Project. The chemistry of these complexes is also important in the areas of nuclear fuel reprocessing and purification, actinide separations, and environmental studies. This report describes initial experiments performed to determine the identity and equilibrium quotients of plutonium(IV) carbonate complexes. These experiments were performed at pH values between 7.2 and 9.6 using a spectrophotometric method. In addition, a brief review of the published literature on Pu(IV) carbonate complexes is presented. Since Pu(IV) exhibits low solubility in the near-neutral pH range, a complex-competition reaction where citrate ligands compete with carbonate ions for the plutonium will be employed. This will permit us to study the pure carbonate system; study the mixed carbonate/citrate system, and confirm and extend the literature work on the pure citrate system. The current experiments have demonstrated the existence of at least three distinct species in the pH region studied. This work will continue in the extended study of the pure citrate system, followed by the investigation of the citrate/carbonate complex/competition reaction. 9 refs., 4 figs., 2 tabs

Gulf of Mexico sales 147 and 150: Central and western planning areas. Draft environmental impact statement. Volume 2. Sections IV.D through IX. Draft report

International Nuclear Information System (INIS)

1993-04-01

Contents: environmental impacts of the proposed actions and alternatives; proposed central gulf sale 147; proposed western gulf sale 150; analysis of a large oil spill; consultation and coordination; bibliography and special references; glossary; appendices

Måleegenskaper ved den norske versjonen av ADHD Rating Scale IV, Skoleversjon (ADHD-RS-IV Skole)

OpenAIRE

Kornør, Hege; Bøe, Tormod

2011-01-01

- Beskrivelse. ADHD-RS-IV Skole er et spørreskjema som skal fylles ut av lærere eller førskolelærere for å fange opp ADHD-symptomer hos barn og ungdom. Spørreskjemaet har 18 ledd med fire svaralternativer. Det tar under 20 minutter å fylle ut. Hovedskalaen og de to delskalaene skåres ved å summere enkeltskårer. Kompetansekrav for bruk av ADHD-RS-IV inkluderer generell opplæring i testbruk, samt yrkesstatus som psykolog, lege, annet helsepersonell med utdanning på mastergradsnivå, spesialpe...

Brush Day & Night Phase III to Phase IV: ensuring that good oral health habits are sustainable.

Science.gov (United States)

Melo, Paulo; Fine, Charlotte; Malone, Sinead; Horn, Virginie

2018-05-01

Over the past 10 years, the FDI-Unilever Brush Day & Night partnership has significantly influenced the life of children worldwide through the implementation of school programmes for oral health education and prevention. This article reports the key facts and outcomes of Phase III of the partnership, and announces the launch of Phase IV. During Phase III, the expert advisors of the Brush Day & Night partnership conducted a longitudinal study to evaluate the impact of the '21 Day' programme in almost 8,000 children in 10 countries. Analysis revealed the effectiveness of the 21 Day programme in sustainably educating children to brush their teeth twice a day, with the greatest impact observed in children aged 7-9 years. With the launch of Phase IV, the Brush Day & Night partnership will continue to deliver its oral health school programme for 7-9 year-old children with a strengthened methodology, including randomized sampling and control groups. The scope of the evaluation will be broadened to include oral health-related quality of life indicators, and monitoring of the oral health knowledge of children's parents/carers. © 2018 FDI World Dental Federation.

Immunohistochemical Analysis of Collagen IV and Laminin Expression in Spontaneous Melanoma Regression in the Melanoma-Bearing Libechov Minipig

Czech Academy of Sciences Publication Activity Database

Plánská, Daniela; Burocziová, Monika; Strnádel, Ján; Horák, Vratislav

2015-01-01

Roč. 48, č. 1 (2015), s. 15-26 ISSN 0044-5991 R&D Projects: GA MŠk ED2.1.00/03.0124 Institutional support: RVO:67985904 ; RVO:61388971 Keywords : collagen IV * laminin * MeLiM * porcine melanoma * spontaneous regression Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 0.912, year: 2015

Dipeptidyl peptidase IV in two human glioma cell lines

Directory of Open Access Journals (Sweden)

A Sedo

2009-12-01

Full Text Available There is growing evidence that dipeptidyl peptidase IV [DPP-IV, EC 3.4.14.5] takes part in the metabolism of biologically active peptides participating in the regulation of growth and transformation of glial cells. However, the knowledge on the DPP-IV expression in human glial and glioma cells is still very limited. In this study, using histochemical and biochemical techniques, the DPP-IV activity was demonstrated in two commercially available human glioma cell lines of different transformation degree, as represented by U373 astrocytoma (Grade III and U87 glioblastoma multiforme (Grade IV lines. Higher total activity of the enzyme, as well as its preferential localisation in the plasma membrane, was observed in U87 cells. Compared to U373 population, U87 cells were morphologically more pleiomorphic, they were cycling at lower rate and expressing less Glial Fibrillary Acidic Protein. The data revealed positive correlation between the degree of transformation of cells and activity of DPP-IV. Great difference in expression of this enzyme, together with the phenotypic differences of cells, makes these lines a suitable standard model for further 57 studies of function of this enzyme in human glioma cells.

Psychological variables and Wechsler Adult Intelligence Scale-IV performance.

Science.gov (United States)

Gass, Carlton S; Gutierrez, Laura

2017-01-01

The MMPI-2 and WAIS-IV are commonly used together in neuropsychological evaluations yet little is known about their interrelationships. This study explored the potential influence of psychological factors on WAIS-IV performance in a sample of 180 predominantly male veteran referrals that underwent a comprehensive neuropsychological examination in a VA Medical Center. Exclusionary criteria included failed performance validity testing and self-report distortion on the MMPI-2. A Principal Components Analysis was performed on the 15 MMPI-2 content scales, yielding three broader higher-order psychological dimensions: Internalized Emotional Dysfunction (IED), Externalized Emotional Dysfunction (EED), and Fear. Level of IED was not related to performance on the WAIS-IV Full Scale IQ or its four indexes: (Verbal Comprehension, Perceptual Reasoning, Working Memory, and Processing Speed). EED was not related to WAIS-IV performance. Level of Fear, which encompasses health preoccupations (HEA) and distorted perceptions (BIZ), was significantly related to WAIS-IV Full Scale IQ and Verbal Comprehension. These results challenge the common use of high scores on the MMPI-2 IED measures (chiefly depression and anxiety) to explain deficient WAIS-IV performance. In addition, they provide impetus for further investigation of the relation between verbal intelligence and Fear.

Chemical nature of implant-derived titanium(IV) ions in synovial fluid

International Nuclear Information System (INIS)

Silwood, Christopher J.L.; Grootveld, Martin

2005-01-01

Previous investigations have indicated a deleterious leakage of Ti(III) and/or Ti(IV) species from Ti-Al-V alloy joint prostheses into adjacent tissue, synovium or synovial fluid (SF) in vivo. In view of the importance of the particular chemical nature of such complexes in determining their biological activity, we have employed high field proton ( 1 H) NMR spectroscopy to 'speciate' Ti(IV) in inflammatory SF. Treatment of osteoarthritic SF samples with increasing concentrations of Ti(IV) (0.10-1.03 mM [TiO(C 2 O 4 ) 2 ] 2- ) gave rise to a specific broadening of the citrate proton resonances, indicating that this bioavailable oxygen-donor ligand plays an important role in complexing implant-derived Ti(IV). 1 H NMR analysis of Ti(IV)-loaded SF samples subsequently treated with a large excess of ascorbate (0.05 M) showed that this added Ti(IV) chelator was only poorly effective in removing this metal ion from Ti(IV)-citrate/Ti(IV)-oxycitrate complexes. The results obtained here provide evidence for complexation of the low-molecular-mass (non-protein-bound) fraction of implant-derived Ti(IV) by citrate in vivo

The Impact of the Hospital Volume on the Performance of Residents on the General Medicine In-Training Examination: A Multicenter Study in Japan.

Science.gov (United States)

Mizuno, Atsushi; Tsugawa, Yusuke; Shimizu, Taro; Nishizaki, Yuji; Okubo, Tomoya; Tanoue, Yusuke; Konishi, Ryota; Shiojiri, Toshiaki; Tokuda, Yasuharu

2016-01-01

Objective Although several studies have been conducted worldwide on factors that might improve residents' knowledge, the relationship between the hospital volume and the internal medicine residents' knowledge has not been fully understood. We conducted a cross-sectional study to compare the relationships of the hospital volume and hospital resources with the residents' knowledge assessed by the In-training Examination. Methods We conducted a retrospective survey and a clinical knowledge evaluation of postgraduate year 1 and 2 (PGY-1 and -2) resident physicians in Japan by using the General Medicine In-training Examination (GM-ITE) in 2014. We compared the ITE score and the hospital volume. Results A total of 2,015 participants (70.6% men; age, 27.3±2.9 years old) from 208 hospitals were retrospectively analyzed. Generalized estimating equations were used, and the results revealed that an increasing number of hospitalizations, decreasing staff number, decreasing age and PGY-2 were significantly associated with higher GM-ITE scores. Conclusion The hospital volume, such as the number of hospitalizations, is thus considered to have a positive impact on the GM-ITE scores.

Impact of contrast injection and stent-graft implantation on reproducibility of volume measurements in semiautomated segmentation of abdominal aortic aneurysm on computed tomography

Energy Technology Data Exchange (ETDEWEB)

Morin-Roy, Florence; Hadjadj, Sofiane; Thomas, Olivier; Yang, Dan Yang [Centre Hospitalier Universitaire de Montreal (CHUM), Hopital Notre-Dame, Department of Radiology, Montreal, Quebec (Canada); Kauffmann, Claude [University of Montreal, Centre de Recherche, Centre Hospitalier Universitaire de Montreal (CRCHUM), Montreal, Quebec (Canada); Tang, An [University of Montreal, Centre de Recherche, Centre Hospitalier Universitaire de Montreal (CRCHUM), Montreal, Quebec (Canada); Centre Hospitalier Universitaire de Montreal (CHUM), Hopital Saint-Luc, Department of Radiology, Montreal, Quebec (Canada); Piche, Nicolas [Object Research System, Montreal, Quebec (Canada); Elkouri, Stephane [Centre Hospitalier Universitaire de Montreal (CHUM), Hopital Hotel-Dieu, Department of Vascular surgery, Montreal, Quebec (Canada); Therasse, Eric [University of Montreal, Centre de Recherche, Centre Hospitalier Universitaire de Montreal (CRCHUM), Montreal, Quebec (Canada); Centre Hospitalier Universitaire de Montreal (CHUM), Hopital Hotel-Dieu, Department of Radiology, Montreal, Quebec (Canada); Soulez, Gilles [Centre Hospitalier Universitaire de Montreal (CHUM), Hopital Notre-Dame, Department of Radiology, Montreal, Quebec (Canada); University of Montreal, Centre de Recherche, Centre Hospitalier Universitaire de Montreal (CRCHUM), Montreal, Quebec (Canada)

2014-07-15

To assess the impact of contrast injection and stent-graft implantation on feasibility, accuracy, and reproducibility of abdominal aortic aneurysm (AAA) volume and maximal diameter (D-max) measurements using segmentation software. CT images of 80 subjects presenting AAA were divided into four equal groups: with or without contrast enhancement, and with or without stent-graft implantation. Semiautomated software was used to segment the aortic wall, once by an expert and twice by three readers. Volume and D-max reproducibility was estimated by intraclass correlation coefficients (ICC), and accuracy was estimated between the expert and the readers by mean relative errors. All segmentations were technically successful. The mean AAA volume was 167.0 ± 82.8 mL and the mean D-max 55.0 ± 10.6 mm. Inter- and intraobserver ICCs for volume and D-max measurements were greater than 0.99. Mean relative errors between readers varied between -1.8 ± 4.6 and 0.0 ± 3.6 mL. Mean relative errors in volume and D-max measurements between readers showed no significant difference between the four groups (P ≥ 0.2). The feasibility, accuracy, and reproducibility of AAA volume and D-max measurements using segmentation software were not affected by the absence of contrast injection or the presence of stent-graft. (orig.)

Pilot study: Exposure and materiality of the secondary room and its impact in the impulse response of coupled-volume concert halls

Science.gov (United States)

Ermann, Michael; Johnson, Marty E.

2002-05-01

What does one room sound like when it is partially exposed to another (acoustically coupled)? More specifically, this research aims to quantify how operational and design decisions impact aural impressions in the design of concert halls with acoustical coupling. By adding a second room to a concert hall, and designing doors to control the sonic transparency between the two rooms, designers can create a new, coupled acoustic. Concert halls use coupling to achieve a variable, longer, and distinct reverberant quality for their musicians and listeners. For this study, a coupled-volume shoebox concert hall was conceived with a fixed geometric volume, form, and primary-room sound absorption. Aperture size and secondary-room sound-absorption levels were established as variables. Statistical analysis of sound decay in this simulated hall suggests a highly sensitive relationship between the double-sloped condition and (1) Architectural composition, as defined by the aperture size exposing the chamber and (2) Materiality, as defined by the sound absorbance in the coupled volume. Preliminary calculations indicate that the double-sloped sound decay condition only appears when the total aperture area is less than 1.5% of the total shoebox surface area and the average absorption coefficient of the coupled volume is less than 0.07.

Estimating traffic volume on Wyoming low volume roads using linear and logistic regression methods

Directory of Open Access Journals (Sweden)

Dick Apronti

2016-12-01

Full Text Available Traffic volume is an important parameter in most transportation planning applications. Low volume roads make up about 69% of road miles in the United States. Estimating traffic on the low volume roads is a cost-effective alternative to taking traffic counts. This is because traditional traffic counts are expensive and impractical for low priority roads. The purpose of this paper is to present the development of two alternative means of cost-effectively estimating traffic volumes for low volume roads in Wyoming and to make recommendations for their implementation. The study methodology involves reviewing existing studies, identifying data sources, and carrying out the model development. The utility of the models developed were then verified by comparing actual traffic volumes to those predicted by the model. The study resulted in two regression models that are inexpensive and easy to implement. The first regression model was a linear regression model that utilized pavement type, access to highways, predominant land use types, and population to estimate traffic volume. In verifying the model, an R2 value of 0.64 and a root mean square error of 73.4% were obtained. The second model was a logistic regression model that identified the level of traffic on roads using five thresholds or levels. The logistic regression model was verified by estimating traffic volume thresholds and determining the percentage of roads that were accurately classified as belonging to the given thresholds. For the five thresholds, the percentage of roads classified correctly ranged from 79% to 88%. In conclusion, the verification of the models indicated both model types to be useful for accurate and cost-effective estimation of traffic volumes for low volume Wyoming roads. The models developed were recommended for use in traffic volume estimations for low volume roads in pavement management and environmental impact assessment studies.

Differentiation of grade II/III and grade IV glioma by combining ''T1 contrast-enhanced brain perfusion imaging'' and susceptibility-weighted quantitative imaging

International Nuclear Information System (INIS)

Saini, Jitender; Gupta, Pradeep Kumar; Gupta, Rakesh Kumar; Sahoo, Prativa; Singh, Anup; Patir, Rana; Ahlawat, Suneeta; Beniwal, Manish; Thennarasu, K.; Santosh, Vani

2018-01-01

MRI is a useful method for discriminating low- and high-grade glioma using perfusion MRI and susceptibility-weighted imaging (SWI). The purpose of this study is to evaluate the usefulness of T1-perfusion MRI and SWI in discriminating among grade II, III, and IV gliomas. T1-perfusion MRI was used to measure relative cerebral blood volume (rCBV) in 129 patients with glioma (70 grade IV, 33 grade III, and 26 grade II tumors). SWI was also used to measure the intratumoral susceptibility signal intensity (ITSS) scores for each tumor in these patients. rCBV and ITSS values were compared to seek differences between grade II vs. grade III, grade III vs. grade IV, and grade III+II vs. grade IV tumors. Significant differences in rCBV values of the three grades of the tumors were noted and pairwise comparisons showed significantly higher rCBV values in grade IV tumors as compared to grade III tumors, and similarly increased rCBV was seen in the grade III tumors as compared to grade II tumors (p < 0.001). Grade IV gliomas showed significantly higher ITSS scores on SWI as compared to grade III tumors (p < 0.001) whereas insignificant difference was seen on comparing ITSS scores of grade III with grade II tumors. Combining the rCBV and ITSS resulted in significant improvement in the discrimination of grade III from grade IV tumors. The combination of rCBV values derived from T1-perfusion MRI and SWI derived ITSS scores improves the diagnostic accuracy for discrimination of grade III from grade IV gliomas. (orig.)

Differentiation of grade II/III and grade IV glioma by combining ''T1 contrast-enhanced brain perfusion imaging'' and susceptibility-weighted quantitative imaging

Energy Technology Data Exchange (ETDEWEB)

Saini, Jitender [National Institute of Mental Health and Neurosciences, Neuroimaging and Interventional Radiology, Bangalore (India); Gupta, Pradeep Kumar; Gupta, Rakesh Kumar [Fortis Memorial Research Institute, Department of Radiology and Imaging, Gurugram (India); Sahoo, Prativa [Philips Health System, Philips India Limited, Bangalore (India); Beckman Research Institute, Mathematical Oncology, Duarte, CA (United States); Singh, Anup [Indian Institute of Technology Delhi, Center for Biomedical Engineering, Delhi (India); Patir, Rana [Fortis Memorial Research Institute, Department of Neurosurgery, Gurugram (India); Ahlawat, Suneeta [Fortis Memorial Research Institute, SRL Diagnostics, Gurugram (India); Beniwal, Manish [National Institute of Mental Health and Neurosciences, Department of Neurosurgery, Bangalore (India); Thennarasu, K. [National Institute of Mental Health and Neurosciences, Department of Biostatistics, Bangalore (India); Santosh, Vani [National Institute of Mental Health and Neurosciences, Department of Neuropathology, Bangalore (India)

2018-01-15

MRI is a useful method for discriminating low- and high-grade glioma using perfusion MRI and susceptibility-weighted imaging (SWI). The purpose of this study is to evaluate the usefulness of T1-perfusion MRI and SWI in discriminating among grade II, III, and IV gliomas. T1-perfusion MRI was used to measure relative cerebral blood volume (rCBV) in 129 patients with glioma (70 grade IV, 33 grade III, and 26 grade II tumors). SWI was also used to measure the intratumoral susceptibility signal intensity (ITSS) scores for each tumor in these patients. rCBV and ITSS values were compared to seek differences between grade II vs. grade III, grade III vs. grade IV, and grade III+II vs. grade IV tumors. Significant differences in rCBV values of the three grades of the tumors were noted and pairwise comparisons showed significantly higher rCBV values in grade IV tumors as compared to grade III tumors, and similarly increased rCBV was seen in the grade III tumors as compared to grade II tumors (p < 0.001). Grade IV gliomas showed significantly higher ITSS scores on SWI as compared to grade III tumors (p < 0.001) whereas insignificant difference was seen on comparing ITSS scores of grade III with grade II tumors. Combining the rCBV and ITSS resulted in significant improvement in the discrimination of grade III from grade IV tumors. The combination of rCBV values derived from T1-perfusion MRI and SWI derived ITSS scores improves the diagnostic accuracy for discrimination of grade III from grade IV gliomas. (orig.)

Redox reactions of U(IV) and Pu(IV) with H2O2 generated in nitric acid media by power ultrasound

International Nuclear Information System (INIS)

Moisy, P.; Venault, L.; Madic, C.; Nikitenko, S.

1998-01-01

Power ultrasound causes water molecule dissociation on H o and OH o radicals due to high local temperatures and pressures generated in the cavitation threshold. In nitric acid media scavenging of OH o radicals with NO 3 - followed by NO 3 o radicals hydrolysis leads to H 2 O 2 formation. It was shown that H 2 O 2 generated under the effect of ultrasound with the frequency 20 kHz and intensity 1-3 Wcm -2 (Ar atmosphere) oxidizes U(IV) to U(VI) or reduces Pu(IV) to Pu(III) in 1-4 M HNO 3 in the presence of antinitrous reagents ( N 2 H 5 NO 3 or NH 2 SO 3 H). The effect of HNO 3 concentration and ultrasonic intensity on the kinetics of U(IV) oxidation and Pu(IV) reduction was studied. (author)

Uranium(IV) adsorption by natural organic matter in anoxic sediments

Energy Technology Data Exchange (ETDEWEB)

Bone, Sharon E.; Dynes, James; Cliff, John B.; Barger, John

2017-01-09

Uranium is an important fuel source and a global environmental contaminant. It accumulates in the tetravalent state, U(IV), in anoxic sediments, including ore deposits, marine basins, and contaminated aquifers. However, very little is known about the speciation of U(IV) in low temperature geochemical environments, inhibiting the development of a conceptual model of U behavior. Until recently, U(IV) was assumed to exist predominantly as the sparingly soluble mineral uraninite (UO₂) in anoxic sediments; yet studies now show that UO₂ is not often dominant in these environments. However, a model of U(IV) speciation under environmentally relevant conditions has not yet been developed. Here we show that complexes of U(IV) adsorb on organic carbon and organic carbon-coated clays in an organic-rich natural substrate under field-relevant conditions. Whereas previous research assumed that the U(IV) product depended on the reduction pathway, our results demonstrate that UO₂ formation can be inhibited simply by decreasing the U:solid ratio. Thus, it is the number and type of surface ligands that controls U(IV) speciation subsequent to U(VI) reduction. Projections of U transport and bioavailability, and thus its threat to human and ecosystem health, must consider retention of U(IV) ions within the local sediment environment.

Does estradiol have an impact on the dipeptidyl peptidase IV enzyme activity of the Prevotella intermedia group bacteria?

Science.gov (United States)

Fteita, Dareen; Könönen, Eija; Gürsoy, Mervi; Söderling, Eva; Gürsoy, Ulvi Kahraman

2015-12-01

Initiation and development of pregnancy-associated gingivitis is seemingly related to the microbial shift towards specific gram-negative anaerobes in subgingival biofilms. It is known that Prevotella intermedia sensu lato is able to use estradiol as an alternative source of growth instead of vitamin K. The aim of the present study was to investigate the impact of estradiol on the bacterial dipeptidyl peptidase IV (DPPIV) enzyme activity in vitro as a virulent factor of the Prevotella intermedia group bacteria, namely P. intermedia, Prevotella nigrescens, Prevotella pallens, and Prevotella aurantiaca. In all experiments, 2 strains of each Prevotella species were used. Bacteria were incubated with the concentrations of 0, 30, 90, and 120 nmol/L of estradiol and were allowed to build biofilms at an air-solid interface. DPPIV activities of biofilms were measured kinetically during 20 min using a fluorometric assay. The enzyme activity was later related to the amount of protein produced by the same biofilm, reflecting the biofilm mass. Estradiol significantly increased DPPIV activities of the 8 Prevotella strains in a strain- and dose-dependent manner. In conclusion, our in vitro experiments indicate that estradiol regulates the DPPIV enzyme activity of P. intermedia, P. nigrescens, P. pallens, and P. aurantiaca strains differently. Our results may, at least partly, explain the role of estradiol to elicit a virulent state which contributes to the pathogenesis of pregnancy-related gingivitis. Copyright © 2015 Elsevier Ltd. All rights reserved.

Electro-regeneration of Ce(IV) in real spent Cr-etching solutions

International Nuclear Information System (INIS)

Chen, Te-San; Huang, Kuo-Lin

2013-01-01

Highlights: • An electrochemical process is used to regenerate Ce(IV) in real (hazardous) spent TFT-LCD Cr-etching solutions. • The Ce(IV) yield on tested anodes was in order BDD > Pt > DSA. • A Neosepta CMX separator was better than Nafion ones to be used in the process. • The activation energy on Pt was 10.7 kJ/mol. • The obtained parameters are useful to design reactors for 100% Ce(IV) regeneration in real spent Cr-etching solutions. -- Abstract: This paper presents the electro-regeneration of Ce(IV) in real (hazardous) spent thin-film transistor liquid-crystal display (TFT-LCD) Cr-etching solutions. In addition to Ce(III) > Ce(IV) in diffusivity, a quasi-reversible behavior of Ce(III)/Ce(IV) was observed at both boron-doped diamond (BDD) and Pt disk electrodes. The Ce(IV) yield on Pt increased with increasing current density, and the best current efficiency (CE) was obtained at 2 A/2.25 cm 2 . The performance in terms of Ce(IV) yield and CE of tested anodes was in order BDD > Pt > dimensional stable anode (DSA). At 2 A/2.25 cm 2 on Pt and 40 °C for 90 min, the Ce(IV) yield, CE and apparent rate constant (k) for Ce(III) oxidation were 81.4%, 21.8% and 3.17 × 10 −4 s −1 , respectively. With the increase of temperature, the Ce(IV) yield, CE, and k increased (activation energy = 10.7 kJ/mol), but the specific electricity consumption decreased. The Neosepta CMX membrane was more suitable than Nafion-117 and Nafion-212 to be used as the separator of the Ce(IV) regeneration process. The obtained parameters are useful to design divided batch reactors for the Ce(IV) electro-regeneration in real spent Cr-etching solutions

Crystal structure of the apurinic/apyrimidinic endonuclease IV from Mycobacterium tuberculosis.

Science.gov (United States)

Zhang, Wei; Xu, Yueyang; Yan, Mengrong; Li, Shanshan; Wang, Huiying; Yang, Haitao; Zhou, Weihong; Rao, Zihe

2018-03-25

Endonuclease IV is a typical endonuclease of the apurinic-apyrimidinic (AP) or abasic endonuclease superfamily. It repairs damaged DNA through base excision repair by cleaving the DNA backbone immediately 5' of an AP site. In Mycobacterium tuberculosis, endonuclease IV is the major AP endonuclease. This enzyme is absent from mammalian cells, making it an attractive target for anti-tuberculosis drug development. In this study, the structure of the recombinant endonuclease IV from M. tuberculosis (MtbEndo IV) was determined at a high resolution of 1.18 Å. MtbEndo IV was found to have a classical α8β8-fold TIM barrel with loops on its surface connecting the α-helices and β-strands that constitute a groove for DNA binding. Three zinc ions were identified at the active site. A comparison between the structures of MtbEndo IV and Escherichia coli End IV suggested that Gln32 of MtbEndo IV may plays a role in regulating substrate binding. Copyright © 2018. Published by Elsevier Inc.

The Impact of Heart Irradiation on Dose-Volume Effects in the Rat Lung

International Nuclear Information System (INIS)

Luijk, Peter van; Faber, Hette; Meertens, Harm; Schippers, Jacobus M.; Langendijk, Johannes A.; Brandenburg, Sytze; Kampinga, Harm H.; Coppes, Robert P. Ph.D.

2007-01-01

Purpose: To test the hypothesis that heart irradiation increases the risk of a symptomatic radiation-induced loss of lung function (SRILF) and that this can be well-described as a modulation of the functional reserve of the lung. Methods and Materials: Rats were irradiated with 150-MeV protons. Dose-response curves were obtained for a significant increase in breathing frequency after irradiation of 100%, 75%, 50%, or 25% of the total lung volume, either including or excluding the heart from the irradiation field. A significant increase in the mean respiratory rate after 6-12 weeks compared with 0-4 weeks was defined as SRILF, based on biweekly measurements of the respiratory rate. The critical volume (CV) model was used to describe the risk of SRILF. Fits were done using a maximum likelihood method. Consistency between model and data was tested using a previously developed goodness-of-fit test. Results: The CV model could be fitted consistently to the data for lung irradiation only. However, this fitted model failed to predict the data that also included heart irradiation. Even refitting the model to all data resulted in a significant difference between model and data. These results imply that, although the CV model describes the risk of SRILF when the heart is spared, the model needs to be modified to account for the impact of dose to the heart on the risk of SRILF. Finally, a modified CV model is described that is consistent to all data. Conclusions: The detrimental effect of dose to the heart on the incidence of SRILF can be described by a dose dependent decrease in functional reserve of the lung

77 FR 64398 - Order of Succession for HUD Region IV

Science.gov (United States)

2012-10-19

... Region IV AGENCY: Office of Field Policy and Management, HUD. ACTION: Notice of Order of Succession... Field Offices (Region IV). This Order of Succession supersedes all previous Orders of Succession for HUD Region IV. DATES: Effective Date: October 9, 2012. FOR FURTHER INFORMATION CONTACT: Lawrence D. Reynolds...

Spectroscopy and chemistry of uranium IV

International Nuclear Information System (INIS)

Folcher, G.; Rigny, P.

1980-06-01

Different fundamental research papers on uranium IV are presented, some were never edited. Molecular spectroscopy was used for identification and structural study of uranium IV in aqueous or organic solutions. The fields studied are: coordination, stereochemistry, electronic structure and chemical properties. For interpretation of results some studies were made with solid compounds or with thorium compounds or thorium complexes. Knowledge of actinides chemistry is improved, uranium and thorium being models for 5 f ions, extractive chemistry is better understood and new applications are possible [fr

The Capsicum annuum class IV chitinase ChitIV interacts with receptor-like cytoplasmic protein kinase PIK1 to accelerate PIK1-triggered cell death and defence responses

Science.gov (United States)

Kim, Dae Sung; Kim, Nak Hyun; Hwang, Byung Kook

2015-01-01

The pepper receptor-like cytoplasmic protein kinase, CaPIK1, which mediates signalling of plant cell death and defence responses was previously identified. Here, the identification of a class IV chitinase, CaChitIV, from pepper plants (Capsicum annuum), which interacts with CaPIK1 and promotes CaPIK1-triggered cell death and defence responses, is reported. CaChitIV contains a signal peptide, chitin-binding domain, and glycol hydrolase domain. CaChitIV expression was up-regulated by Xanthomonas campestris pv. vesicatoria (Xcv) infection. Notably, avirulent Xcv infection rapidly induced CaChitIV expression in pepper leaves. Bimolecular fluorescence complementation and co-immunoprecipitation revealed that CaPIK1 interacts with CaChitIV in planta, and that the CaPIK1–CaChitIV complex is localized mainly in the cytoplasm and plasma membrane. CaChitIV is also localized in the endoplasmic reticulum. Transient co-expression of CaChitIV with CaPIK1 enhanced CaPIK1-triggered cell death response and reactive oxygen species (ROS) and nitric oxide (NO) bursts. Co-silencing of both CaChitIV and CaPIK1 in pepper plants conferred enhanced susceptibility to Xcv infection, which was accompanied by a reduced induction of cell death response, ROS and NO bursts, and defence response genes. Ectopic expression of CaPIK1 in Arabidopsis enhanced basal resistance to Hyaloperonospora arabidopsidis infection. Together, the results suggest that CaChitIV positively regulates CaPIK1-triggered cell death and defence responses through its interaction with CaPIK1. PMID:25694549

Determination of U(IV) and hydrazine nitrate by volumetry

International Nuclear Information System (INIS)

Cao Xi; Wang Nanjie; Zhang Tao; Wang Lin; Guo Yuhua

2006-01-01

To be determined U(IV) and hydrazine nitrate in exist together, chromium (VI) and 1,10-phenanthroline is used individually as oxidation titrator and indicator for U(IV), and N-bromineimino and methyl red is used individually as oxidation titrator and indicator for hydrazine nitrate, U(IV) and hydrazine nitrate in the same sample is determined sequentially in the nitric acid by adjusting concentration of nitric acid. Results show that the precision is better than 2.0% when the mass concentration of U(IV) is ranged over 5.5-205 mg/mL; and the precision is better than 2.0% when the concentration of hydrazine nitrate is ranged over 0.05-1.0 mol/L. (authors)

Complexation of Plutonium (IV) With Sulfate At Variable Temperatures

International Nuclear Information System (INIS)

Y. Xia; J.I. Friese; D.A. Moore; P.P. Bachelor; L. Rao

2006-01-01

The complexation of plutonium(IV) with sulfate at variable temperatures has been investigated by solvent extraction method. A NaBrO 3 solution was used as holding oxidant to maintain the plutonium(IV) oxidation state throughout the experiments. The distribution ratio of Pu(IV) between the organic and aqueous phases was found to decrease as the concentrations of sulfate were increased. Stability constants of the 1:1 and 1:2 Pu(IV)-HSO 4 - complexes, dominant in the aqueous phase, were calculated from the effect of [HSO 4 - ] on the distribution ratio. The enthalpy and entropy of complexation were calculated from the stability constants at different temperatures using the Van't Hoff equation

The I-V Measurement System for Solar Cells Based on MCU

International Nuclear Information System (INIS)

Chen Fengxiang; Ai Yu; Wang Jiafu; Wang Lisheng

2011-01-01

In this paper, an I-V measurement system for solar cells based on Single-chip Microcomputer (MCU) is presented. According to the test principles of solar cells, this measurement system mainly comprises of two parts-data collecting, data processing and displaying. The MCU mainly used as to acquire data, then the collecting results is sent to the computer by serial port. The I-V measurement results of our test system are shown in the human-computer interaction interface based on our hardware circuit. By comparing the test results of our I-V tester and the results of other commercial I-V tester, we found errors for most parameters are less than 5%, which shows our I-V test result is reliable. Because the MCU can be applied in many fields, this I-V measurement system offers a simple prototype for portable I-V tester for solar cells.

The I-V Measurement System for Solar Cells Based on MCU

Energy Technology Data Exchange (ETDEWEB)

Chen Fengxiang; Ai Yu; Wang Jiafu; Wang Lisheng, E-mail: phonixchen79@yahoo.com.cn [Department of physics science and technology, Wuhan University of Technology, Wuhan city, Hubei Province, 430070 (China)

2011-02-01

In this paper, an I-V measurement system for solar cells based on Single-chip Microcomputer (MCU) is presented. According to the test principles of solar cells, this measurement system mainly comprises of two parts-data collecting, data processing and displaying. The MCU mainly used as to acquire data, then the collecting results is sent to the computer by serial port. The I-V measurement results of our test system are shown in the human-computer interaction interface based on our hardware circuit. By comparing the test results of our I-V tester and the results of other commercial I-V tester, we found errors for most parameters are less than 5%, which shows our I-V test result is reliable. Because the MCU can be applied in many fields, this I-V measurement system offers a simple prototype for portable I-V tester for solar cells.

Some studies on the reaction between nitrous acid and plutonium(IV)

International Nuclear Information System (INIS)

Vasudeva Rao, P.R.; Bagawde, S.V.; Ramakrishna, V.V.; Patil, S.K.

1976-01-01

In the ion exchange and solvent extraction studies nitrous acid is used as an oxidant for Pu(IV) in perchloric acid. Earlier studies had indicated that Pu(IV) forms complex with nitrous acid. The present investigation aimed to study this complex formation by solvent extraction and spectrophotometric methods, revealed that is no significant complex formation between Pu(IV) and nitrous acid. The high apparent equilibrium constant for the complex formation is caused by the partial reduction of Pu(IV) to Pu(III) by nitrous acid. The nitrate complexing is negligible in the case of Th(IV) and Np(IV) as well. Systematic investigation on the redox reactions of plutonium in different oxidation states with nitrous acid is now in progress. The preliminary results obtained indicate that Pu(IV) is reduced to Pu(III) by nitrous acid with a rate that can be conveniently followed spectrophotometrically. (T.I.)

C-terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin

International Nuclear Information System (INIS)

Liu, Sicheng; Liu, Xunyue; Kamdar, Radhika Pankaj; Wanotayan, Rujira; Sharma, Mukesh Kumar; Adachi, Noritaka; Matsumoto, Yoshihisa

2013-01-01

Highlights: •Chromatin binding of XRCC4 is dependent on the presence of DNA ligase IV. •C-terminal region of DNA ligase IV alone can recruit itself and XRCC4 to chromatin. •Two BRCT domains of DNA ligase IV are essential for the chromatin binding of XRCC4. -- Abstract: DNA ligase IV (LIG4) and XRCC4 form a complex to ligate two DNA ends at the final step of DNA double-strand break (DSB) repair through non-homologous end-joining (NHEJ). It is not fully understood how these proteins are recruited to DSBs. We recently demonstrated radiation-induced chromatin binding of XRCC4 by biochemical fractionation using detergent Nonidet P-40. In the present study, we examined the role of LIG4 in the recruitment of XRCC4/LIG4 complex to chromatin. The chromatin binding of XRCC4 was dependent on the presence of LIG4. The mutations in two BRCT domains (W725R and W893R, respectively) of LIG4 reduced the chromatin binding of LIG4 and XRCC4. The C-terminal fragment of LIG4 (LIG4-CT) without N-terminal catalytic domains could bind to chromatin with XRCC4. LIG4-CT with W725R or W893R mutation could bind to chromatin but could not support the chromatin binding of XRCC4. The ability of C-terminal region of LIG4 to interact with chromatin might provide us with an insight into the mechanisms of DSB repair through NHEJ

Long-term risk of complications after mid-urethral sling IVS implantation

Directory of Open Access Journals (Sweden)

Grzegorz Surkont

2015-02-01

Full Text Available [b]Introduction[/b]. Results of short-term evaluation of multifilament microporous midurethral tape IVS differ a great deal. During the first year of implantation, erosions have been observed in 0%–26% of operated women. Long-term observations are rare. They suggest high risk of extrusion and infection even after years of implantation. [b]Objective[/b]. The purpose of the study was to evaluate long-term risk of complications after IVS implantation. Material and methods. Between 2001–2005, 72 women were operated on with the use of IVS mid-urethral tape. [b]Results[/b]. Two women had vaginal erosions during the first 3 months after the operation. Twelve women had vaginal erosions, purulent vaginal discharge, with IVS tape sticking out of the abdominal wall or vagina, and abdominal abscess. These complications were diagnosed between 9 months and 6 years after IVS implantation. The patients were operated on vaginally and open abdominally, 1–5 times because of complications after IVS implantation. [b]Conclusions[/b]. In the case of post-IVS complication, as much tape as possible should be excised. Long-term follow up on patients with IVS implantation should be recommended to the centres where IVS tape was used, even to patients after removal of the tape. Risk of erosion, extrusion and infection after midurethral multifilament microporous IVS tape implantation is too high – which is the reason it should no longer be used.

The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits

Czech Academy of Sciences Publication Activity Database

Česneková, J.; Rodinová, M.; Hansíková, H.; Houštěk, Josef; Zeman, J.; Stibůrek, L.

2016-01-01

Roč. 473, č. 6 (2016), s. 797-804 ISSN 0264-6021 R&D Projects: GA ČR(CZ) GA13-07223S Institutional support: RVO:67985823 Keywords : complex IV * LACE1 * mitochondria * oxidative phosphorylation * YME1L Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.797, year: 2016

Is there any association between National Institute of Health category IV prostatitis and prostate-specific antigen levels in patients with low-risk localized prostate cancer?

Science.gov (United States)

Doluoglu, Omer Gokhan; Ceylan, Cavit; Kilinc, Fatih; Gazel, Eymen; Resorlu, Berkan; Odabas, Oner

2016-01-01

We investigated the association between National Institute of Health category IV prostatitis and prostate-specific antigen levels in patients with low-risk localized prostate cancer. The data of 440 patients who had undergone prostate biopsies due to high PSA levels and suspicious digital rectal examination findings were reviewed retrospectively. The patients were divided into two groups based on the presence of accompanying NIH IV prostatitis. The exclusion criteria were as follows: Gleason score>6, PSA level>20ng/mL, >2 positive cores, >50% cancerous tissue per biopsy, urinary tract infection, urological interventions at least 1 week previously (cystoscopy, urethral catheterization, or similar procedure), history of prostate biopsy, and history of androgen or 5-alpha reductase use. All patient's age, total PSA and free PSA levels, ratio of free to total PSA, PSA density and prostate volume were recorded. In total, 101 patients were included in the study. Histopathological examination revealed only PCa in 78 (77.2%) patients and PCa+NIH IV prostatitis in 23 (22.7%) patients. The median total PSA level was 7.4 (3.5-20.0) ng/mL in the PCa+NIH IV prostatitis group and 6.5 (0.6-20.0) ng/mL in the PCa group (p=0.67). The PSA level was≤10ng/mL in 60 (76.9%) patients in the PCa group and in 16 (69.6%) patients in the PCa+NIH IV prostatitis group (p=0.32). Our study showed no statistically significant difference in PSA levels between patients with and without NIH IV prostatitis accompanying PCa.

Impact of clinical trials on neurosurgical practice: an assessment of case volume.

Science.gov (United States)

Simon, Scott D; Koyama, Tatsuki; Zacharia, Brad E; Schirmer, Clemens M; Cheng, Joseph S

2015-04-01

To evaluate the effect of important trials on the practice of neurosurgery. We hypothesized that evidence from trials addressing the management of intracranial aneurysms (International Subarachnoid Aneurysm Trial [ISAT]) and nontraumatic intracerebral hemorrhages (Surgical Trial in Intracerebral Hemorrhage [STICH]) and vertebral augmentation for osteoporotic vertebral body fractures had a significant impact on the frequency of the corresponding neurosurgical procedures. A Medicare administrative database was queried for corresponding Common Procedural Terminology codes and units billed per calendar year. The effects of ISAT and STICH were evaluated using a generalized linear model. The effect of the vertebral augmentation study was evaluated using a t test. After publication of ISAT in 2002, the rate of increase in proportion of cerebral aneurysms that were treated with embolization (Common Procedural Terminology code 61624) per year increased from 3.9% to 5.5% (P = 0.01). After publication of STICH in 2005, the number of craniotomies performed for intracerebral hematoma decreased from 2341 in 2002 to 1646 in 2011 (P = 0.03). After 2 publications in 2009, performance of vertebral augmentation decreased from a high of 99,961 in 2009 per year to 77,108 in 2013 (P = 0.002). Randomized clinical trials remain the gold standard in the medical community to demonstrate efficacy, but their true impact relies on rapid and extensive assimilation into everyday medical practice. However, the described methodology establishes a temporal relationship only and does not prove causation. Nonetheless, trends in procedural volume suggest that the results of these select randomized clinical trials had a significant effect on neurosurgical practice affecting Medicare patients within an interval of a few years. Copyright © 2015 Elsevier Inc. All rights reserved.

Identification and characterization of a dipeptidyl peptidase IV inhibitor from aronia juice

Energy Technology Data Exchange (ETDEWEB)

Kozuka, Miyuki [Department of Health and Nutrition, Faculty of Human Science, Hokkaido Bunkyo University, Eniwa 061-1449 (Japan); Yamane, Takuya, E-mail: t-yamane@pharm.hokudai.ac.jp [Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812 (Japan); Nakano, Yoshihisa [Center for Research and Development Bioresources, Research Organization for University-Community Collaborations, Osaka Prefecture University, Sakai, Osaka 599-8570 (Japan); Nakagaki, Takenori [Institute of Food Sciences, Nakagaki Consulting Engineer Co., Ltd, Nishi-ku, Sakai 593-8328 (Japan); Ohkubo, Iwao [Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Higashi-ku, Sapporo 065-0013 (Japan); Ariga, Hiroyoshi [Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812 (Japan)

2015-09-25

Aronia berries have many potential effects on health, including an antioxidant effect, effect for antimutagenesis, hepatoprotection and cardioprotection, an antidiabetic effect and inhibition of cancer cell proliferation. Previous human studies have shown that aronia juice may be useful for treatment of obesity disorders. In this study, we found that aronia juice has an inhibitory effect against dipeptidyl peptidase IV (DPP IV) (EC 3.4.14.5). DPP IV is a peptidase that cleaves the N-terminal region of incretins such as glucagon-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Inactivation of incretins by DPP IV induces reduction of insulin secretion. Furthermore, we identified that cyanidin 3, 5-diglucoside as the DPP IV inhibitor in aronia juice. DPP IV was inhibited more strongly by cyanidin 3, 5-diglucoside than by cyanidin and cyanidin 3-glucoside. The results suggest that DPP IV is inhibited by cyanidin 3, 5-diglucoside present in aronia juice. The antidiabetic effect of aronia juice may be mediated through DPP IV inhibition by cyanidin 3, 5-diglucoside. - Highlights: • DPP IV activity is inhibited by aronia juice. • DPP IV inhibitor is cyanidin 3, 5-diglucoside in aronia juice. • DPP IV is inhibited by cyanidin 3, 5-diglucoside more than cyanidin and cyanidin 3-glucoside.

Comparison of the toxicity of the dyes Sudan II and Sudan IV to catalase.

Science.gov (United States)

Li, Tong; Hao, Minglu; Pan, Jie; Zong, Wansong; Liu, Rutao

2017-10-01

The mechanisms of the toxicity of Sudan dyes to the key antioxidant enzyme catalase (CAT) were investigated by spectroscopic methods, calorimetry techniques, enzyme activity assay, and molecular docking. Results showed that Sudan dyes bound to CAT through hydrophobic force, which changed the microenvironment of tryptophan and tyrosine residues, leading to a conformational alteration and shrinkage of the protein. Enzyme activity assay and molecular docking revealed that the activity of CAT was slightly inhibited in the presence of Sudan dyes. In comparison, the binding of Sudan II with CAT was slightly stronger than Sudan IV. Also, Sudan II and Sudan IV showed a different impact on the microenvironment of aromatic amino acid residues. But the dyes had very similar effects on conformation and activity of the protein. This work provides an essential reference for the evaluation of Sudan dyes' effects on body's antioxidant defense system and safe use of Sudan dyes. © 2017 Wiley Periodicals, Inc.

Volume determination of fresh and dried bloodstains by means of optical coherence tomography

NARCIS (Netherlands)

Laan, Nick; Bremmer, Rolf H.; Aalders, Maurice C. G.; de Bruin, Karla G.

2014-01-01

The volume of bloodstains found on crime scenes may help forensic investigators reconstruct the location and kinematics of bloodletting events, as stain size, volume, and impact velocity are related. Optical coherence tomography was used as a method to determine the volume and volume ratio of dried

Måleegenskaper ved den norske versjonen av ADHD Rating Scale – IV Hjemmeversjon (ADHD-RS-IV Hjemme)

OpenAIRE

Kornør, Hege; Bøe, Tormod

2011-01-01

- Beskrivelse. ADHD-RS-IV Hjemme er et spørreskjema som skal fylles ut av mor, far, verge eller besteforeldre for å fange opp ADHD-symptomer hos barn og ungdom. Spørreskjemaet har 18 ledd med fire svaralternativer. Det tar under 20 minutter å fylle ut. Hovedskalaen og de to delskalaene skåres ved å summere enkeltskårer. Kompetansekrav for bruk av ADHD-RS-IV inkluderer generell opplæring i testbruk, samt yrkesstatus som psykolog, lege, annet helsepersonell med utdanning på ...

12 CFR Appendix IV to Part 27 - Home Loan Data Submission

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Home Loan Data Submission IV Appendix IV to Part 27 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FAIR HOUSING HOME LOAN DATA SYSTEM Pt. 27, App. IV Appendix IV to Part 27—Home Loan Data Submission ER21JN94.003 ER21JN94...

Discrepancy between WISC-III and WISC-IV Cognitive Profile in Autism Spectrum: What Does It Reveal about Autistic Cognition?

Science.gov (United States)

Nader, Anne-Marie; Jelenic, Patricia; Soulières, Isabelle

2015-01-01

The cognitive profile and measured intellectual level vary according to assessment tools in children on the autism spectrum, much more so than in typically developing children. The recent inclusion of intellectual functioning in the diagnostic process for autism spectrum disorders leads to the crucial question on how to assess intelligence in autism, especially as some tests and subtests seem more sensitive to certain neurodevelopmental conditions. Our first aim was to examine the cognitive profile on the current version of the most widely used test, the Wechsler Intelligence Scales for Children (WISC-IV), for a homogenous subgroup of children on the autism spectrum, i.e. corresponding to DSM-IV diagnosis of “autism”. The second aim was to compare cognitive profiles obtained on the third edition versus 4th edition of WISC, in order to verify whether the WISC-IV yields a more distinctive cognitive profile in autistic children. The third aim was to examine the impact of the WISC-IV on the cognitive profile of another subgroup, children with Asperger’s Syndrome. 51 autistic, 15 Asperger and 42 typically developing children completed the WISC-IV and were individually matched to children who completed the WISC-III. Divergent WISC-IV profiles were observed despite no significant intelligence quotient difference between groups. Autistic children scored significantly higher on the Perceptual Reasoning Index than on the Verbal Comprehension Index, a discrepancy that nearly tripled in comparison to WISC-III results. Asperger children scored higher on the VCI than on other indexes, with the lowest score found on the Processing Speed Index. WISC-IV cognitive profiles were consistent with, but more pronounced than WISC-III profiles. Cognitive profiles are a valuable diagnostic tool for differential diagnosis, keeping in mind that children on the autism spectrum might be more sensitive to the choice of subtests used to assess intelligence. PMID:26673881

Discrepancy between WISC-III and WISC-IV Cognitive Profile in Autism Spectrum: What Does It Reveal about Autistic Cognition?

Science.gov (United States)

Nader, Anne-Marie; Jelenic, Patricia; Soulières, Isabelle

2015-01-01

The cognitive profile and measured intellectual level vary according to assessment tools in children on the autism spectrum, much more so than in typically developing children. The recent inclusion of intellectual functioning in the diagnostic process for autism spectrum disorders leads to the crucial question on how to assess intelligence in autism, especially as some tests and subtests seem more sensitive to certain neurodevelopmental conditions. Our first aim was to examine the cognitive profile on the current version of the most widely used test, the Wechsler Intelligence Scales for Children (WISC-IV), for a homogenous subgroup of children on the autism spectrum, i.e. corresponding to DSM-IV diagnosis of "autism". The second aim was to compare cognitive profiles obtained on the third edition versus 4th edition of WISC, in order to verify whether the WISC-IV yields a more distinctive cognitive profile in autistic children. The third aim was to examine the impact of the WISC-IV on the cognitive profile of another subgroup, children with Asperger's Syndrome. 51 autistic, 15 Asperger and 42 typically developing children completed the WISC-IV and were individually matched to children who completed the WISC-III. Divergent WISC-IV profiles were observed despite no significant intelligence quotient difference between groups. Autistic children scored significantly higher on the Perceptual Reasoning Index than on the Verbal Comprehension Index, a discrepancy that nearly tripled in comparison to WISC-III results. Asperger children scored higher on the VCI than on other indexes, with the lowest score found on the Processing Speed Index. WISC-IV cognitive profiles were consistent with, but more pronounced than WISC-III profiles. Cognitive profiles are a valuable diagnostic tool for differential diagnosis, keeping in mind that children on the autism spectrum might be more sensitive to the choice of subtests used to assess intelligence.

Discrepancy between WISC-III and WISC-IV Cognitive Profile in Autism Spectrum: What Does It Reveal about Autistic Cognition?

Directory of Open Access Journals (Sweden)

Anne-Marie Nader

Full Text Available The cognitive profile and measured intellectual level vary according to assessment tools in children on the autism spectrum, much more so than in typically developing children. The recent inclusion of intellectual functioning in the diagnostic process for autism spectrum disorders leads to the crucial question on how to assess intelligence in autism, especially as some tests and subtests seem more sensitive to certain neurodevelopmental conditions. Our first aim was to examine the cognitive profile on the current version of the most widely used test, the Wechsler Intelligence Scales for Children (WISC-IV, for a homogenous subgroup of children on the autism spectrum, i.e. corresponding to DSM-IV diagnosis of "autism". The second aim was to compare cognitive profiles obtained on the third edition versus 4th edition of WISC, in order to verify whether the WISC-IV yields a more distinctive cognitive profile in autistic children. The third aim was to examine the impact of the WISC-IV on the cognitive profile of another subgroup, children with Asperger's Syndrome. 51 autistic, 15 Asperger and 42 typically developing children completed the WISC-IV and were individually matched to children who completed the WISC-III. Divergent WISC-IV profiles were observed despite no significant intelligence quotient difference between groups. Autistic children scored significantly higher on the Perceptual Reasoning Index than on the Verbal Comprehension Index, a discrepancy that nearly tripled in comparison to WISC-III results. Asperger children scored higher on the VCI than on other indexes, with the lowest score found on the Processing Speed Index. WISC-IV cognitive profiles were consistent with, but more pronounced than WISC-III profiles. Cognitive profiles are a valuable diagnostic tool for differential diagnosis, keeping in mind that children on the autism spectrum might be more sensitive to the choice of subtests used to assess intelligence.

The Role of Dipeptidyl Peptidase IV in Lung Metastasis of Breast Cancer Cells

Science.gov (United States)

1999-05-01

Our studies focused on (1) cloning and sequencing of wild-type endothelial DPP IV (wtDPP IV) and preparation of truncated DPP IV ( tDPP IV); (2...that was identical to hepatic DPP IV. Acid extraction of rat lung yielded a tDPP IV, which was an effective inhibitor of breast cancer cell adhesion to

The impact of environmental conditions on human performance: A critical review of the literature. Volume 2

International Nuclear Information System (INIS)

Echeverria, D.; Barnes, V.; Bittner, A.